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HIV‚ƃGƒCƒY
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Ÿ HIV‚ƃGƒCƒY Ÿ
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‘S‘I‘ð@ƒ^ƒ“ƒpƒNŽ¿‘I‘ð@ƒŠƒKƒ“ƒh‘I‘ð@DNA/RNA‘I‘ð@DNA‘I‘ð@DNA/RNA backbone‘I‘ð
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‘S‘I‘ð@ƒ^ƒ“ƒpƒNŽ¿‘I‘ð@ƒŠƒKƒ“ƒh‘I‘ð@DNA/RNA‘I‘ð@DNA‘I‘ð@DNA/RNA backbone‘I‘ð
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“œ½•Ê’…Fi#ˆó‚Ì‚ÝjFGalCƒ¿-GlcCƒÀ-GlcCManCFucCXylCSiaCGalNAcCGlcNAcCGlcA
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1t03‚ÌChain AEPETqƒeƒmƒzƒrƒ‹^tenofovir^TDFiŠjŽ_Œn‹t“]ŽÊy‘f‘jŠQÜjr
Ÿ”ñŠjŽ_Œn‹t“]ŽÊy‘f‘jŠQÜŠÖ˜A
1fk9‚ÌChain AqƒGƒtƒ@ƒrƒŒƒ“ƒc^efavirenz^EFVi”ñŠjŽ_Œn‹t“]ŽÊy‘f‘jŠQÜjr
1lwc‚ÌChain Aqƒlƒrƒ‰ƒsƒ“^nevirapine^NVPi”ñŠjŽ_Œn‹t“]ŽÊy‘f‘jŠQÜjr
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2rkiq”ñŠjŽ_Œn‹t“]ŽÊy‘f‘jŠQÜr
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3dlgqGW564511i”ñŠjŽ_Œn‹t“]ŽÊy‘f‘jŠQÜjr
3dok*qGW678248i”ñŠjŽ_Œn‹t“]ŽÊy‘f‘jŠQÜjr
3dolqGW695634i”ñŠjŽ_Œn‹t“]ŽÊy‘f‘jŠQÜjr
3drpqMK-4965i”ñŠjŽ_Œn‹t“]ŽÊy‘f‘jŠQÜjr
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‘S‘I‘ð@ƒ^ƒ“ƒpƒNŽ¿‘I‘ð@ƒŠƒKƒ“ƒh‘I‘ð@DNA/RNA‘I‘ð@DNA‘I‘ð@DNA/RNA backbone‘I‘ð
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“œ½•Ê’…Fi#ˆó‚Ì‚ÝjFGalCƒ¿-GlcCƒÀ-GlcCManCFucCXylCSiaCGalNAcCGlcNAcCGlcA
Ž_«E’†«E‰–Šî«‹æ•Ê@‹É«E”ñ‹É«‹æ•Ê@‘a…«ƒCƒ“ƒfƒbƒNƒX‡@I/O’l‡i“Á«Šî Rj@“™“d“_‡@ƒRƒ“ƒzƒ[ƒVƒ‡ƒ“‘I‘ð«iƒ¿ƒwƒŠƒbƒNƒXEƒÀƒXƒgƒ‰ƒ“ƒhj
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2i5j*qDHBNHi‹t“]ŽÊy‘f‚̈ꕔ‚Å‚ ‚郊ƒ{ƒkƒNƒŒƒA[ƒ[H‘jŠQÜjr
4mbs‚ÌChain Aqƒ}ƒ‰ƒrƒƒN^maravirociƒPƒ‚ƒJƒCƒ“Žó—e‘ÌCCR5‘jŠQÜjr@“¯PDBsumƒf[ƒ^ 4mbs_MRV$@MRViƒ}ƒ‰ƒrƒƒNj‘I‘ð@mCCR5 - WikipediaCMaraviroc - Wikipedian [NEW!GScientist‹LŽ–i2013/09/12jŽQÆ]

ŸƒOƒŠƒbƒhƒRƒ“ƒsƒ…[ƒeƒBƒ“ƒO‚É‚æ‚éHIVŠÖ˜AŽ¡—ÖòŒó•â’Tõ‚Å—p‚¢‚ç‚ꂽƒ^ƒ“ƒpƒNŽ¿
HIV-1 Protease s1a30t š
HIV Integrase s1hyvt š
HIV gp41 s1czqt š
HIV gp120 s1g9mt š

@š Find-a-Drug: Projects - HIViŒ»ÝI—¹GTeam Japan HIVCWorld Community Grid [“ú–{Œê”Å]ŽQÆj‚Å—p‚¢‚ç‚ꂽƒ^ƒ“ƒpƒNŽ¿

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1a8k‚ÌChain A-C kƒvƒƒeƒA[ƒ[l
1u04* kƒAƒ‹ƒSƒm[ƒgiargonautejl
1zlw# kR‘Ì2G12l
2bf1# kSIV—R—ˆ‚Ì”ñŒ‹‡Œ^gp120l
2cmr kgp41C’†˜aR‘Ìl
2exf‚ÌModel 1 kƒkƒNƒŒƒIƒJƒvƒVƒh NCp7CDNAl
2i5y‚ÌChain GEHELEM# kgp120CCD4l
2jzw‚ÌModel 1 kHIV-1CƒkƒNƒŒƒIƒJƒvƒVƒh NCp7C‹t“]ŽÊCDNAl
2nxy# kgp120CCD4CR‘Ì17bl
2oiy kRNAl
2qad# ƒXƒ‹ƒzƒ`ƒƒVƒ“iTysj‘I‘ð kHIV-1Cgp120CCD4CCCR5CR‘Ì412dl
2qsc*# kRHIV-1R‘ÌCgp120l
2rll ƒXƒ‹ƒzƒ`ƒƒVƒ“iTysj‘I‘ð kHIV-1CCCR5 N––’[l
3c3z* kHIV-1C“ñ–{½RNACƒŠƒ{ƒXƒ^ƒ}ƒCƒVƒ“iƒAƒ~ƒmƒOƒŠƒRƒVƒhŒnR¶•¨Ž¿jl
3c44* kHIV-1C“ñ–{½RNACƒpƒƒ‚ƒ}ƒCƒVƒ“iƒAƒ~ƒmƒOƒŠƒRƒVƒhŒnR¶•¨Ž¿jl
3c5d* kHIV-1C“ñ–{½RNACƒŠƒrƒhƒ}ƒCƒVƒ“iƒAƒ~ƒmƒOƒŠƒRƒVƒhŒnR¶•¨Ž¿jl
3c7r* kHIV-1C“ñ–{½RNACƒlƒIƒ}ƒCƒVƒ“iƒAƒ~ƒmƒOƒŠƒRƒVƒhŒnR¶•¨Ž¿jl
3dvv* kHIV-1ƒQƒmƒ€RNAC“ñ–{½RNACƒŠƒ{ƒXƒ^ƒ}ƒCƒVƒ“l
3gut k“]ŽÊˆöŽqp65iACEG½CƒqƒgjCNF-ƒÈBiBDFH½CƒqƒgjCHIV-1 LTRiIJXY½jl
3p05 kHIV-1CƒJƒvƒVƒhl


HIV‚ƃGƒCƒY‚ÌÚ×î•ñ



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ŽQl@‘½Ü•¹—p—Ö@iHAARTj‚Ì—á ¨ Jmol”Å^ƒGƒCƒY–ò‚Ì—á
¦‹gŠJ‘×M •ÒCuƒEƒCƒ‹ƒXE׋ۂƊ´õÇ‚ª‚í‚©‚évCp.102C—r“yŽÐ(2004)
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•\‚P@1970”N‘ãˆÈ~‚ÉoŒ»‚µ‚½Žå‚ÈV‹»Š´õÇ
¦ˆÈ‰º‚Ì•¶Œ£‚©‚çŽå—v•”•ª‚𔲈‚µ‚Ä•ÒW
Š´õÇF’|“c”ü•¶E‰ª•”M•FC
uSARS‚͉½‚ðŒx‚µ‚Ä‚¢‚é‚Ì‚©vCŠâ”gƒuƒbƒNƒŒƒbƒg(2003)
”N V‹»Š´õÇ
•aŒ´”÷¶•¨ Ží—Þ Ž¾•a
 1973  ƒƒ^ƒEƒCƒ‹ƒX ƒEƒCƒ‹ƒX ¬Ž™‚̉º—Ÿ
1977 ƒGƒ{ƒ‰ƒEƒCƒ‹ƒX ƒEƒCƒ‹ƒX ƒGƒ{ƒ‰oŒŒ”M
1977 Legionella pneumophila ×‹Û ƒŒƒWƒIƒlƒ‰ÇiÝ‹½ŒRl•aj
1977 ƒnƒ“ƒ^ƒEƒCƒ‹ƒX ƒEƒCƒ‹ƒX tÇŒó«oŒŒ”M
1980 HTLV-I ƒEƒCƒ‹ƒX ¬lT×–E”’ŒŒ•a
1982 •aŒ´«‘å’°‹ÛO157FH7 ×‹Û oŒŒ«‘å’°‰ŠC—nŒŒ«”A“ÅÇÇŒòŒQ
1983 HIV ƒEƒCƒ‹ƒX ƒGƒCƒY
1983 Helicobacter pylori ×‹Û ˆÝ’×á‡
1988 EŒ^ŠÌ‰ŠƒEƒCƒ‹ƒX ƒEƒCƒ‹ƒX EŒ^ŠÌ‰Š
1989 CŒ^ŠÌ‰ŠƒEƒCƒ‹ƒX ƒEƒCƒ‹ƒX CŒ^ŠÌ‰Š
1992 Vibrio cholerae O139 ×‹Û ƒRƒŒƒ‰
1996 ‹ŠC–Èó”]ǃvƒŠƒIƒ“ ƒvƒŠƒIƒ“iƒ^ƒ“ƒpƒNŽ¿j •ψٌ^ƒNƒƒCƒcƒtƒFƒ‹ƒgEƒ„ƒRƒu•a
1997 ƒgƒŠŒ^ƒCƒ“ƒtƒ‹ƒGƒ“ƒUƒEƒCƒ‹ƒX ƒEƒCƒ‹ƒX ƒCƒ“ƒtƒ‹ƒGƒ“ƒU
1998 ƒjƒpƒEƒCƒ‹ƒX ƒEƒCƒ‹ƒX ”]‰Š
2002 SARSƒRƒƒiƒEƒCƒ‹ƒX ƒEƒCƒ‹ƒX ”x‰Š
2004 ƒgƒŠŒ^ƒCƒ“ƒtƒ‹ƒGƒ“ƒUƒEƒCƒ‹ƒX ƒEƒCƒ‹ƒX ƒCƒ“ƒtƒ‹ƒGƒ“ƒU


•\‚Q@‚¢‚ë‚¢‚ë‚ȃEƒCƒ‹ƒXiDNAƒEƒCƒ‹ƒX‚ÆRNAƒEƒCƒ‹ƒXj
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uƒEƒCƒ‹ƒXE׋ۂƊ´õÇ‚ª‚í‚©‚évCp.37C—r“yŽÐ(2004)
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Žå‚ÈDNAƒEƒCƒ‹ƒX ƒ|ƒbƒNƒXƒEƒCƒ‹ƒX‰È  
ƒwƒ‹ƒyƒXƒEƒCƒ‹ƒX‰È ¦Œïƒwƒ‹ƒyƒX
ƒAƒfƒmƒEƒCƒ‹ƒX‰È  
ƒpƒsƒ[ƒ}ƒEƒCƒ‹ƒX‰È
iƒ|ƒŠƒI[ƒ}ƒEƒCƒ‹ƒX‰È‚à“Ž—j
Žq‹{èò‚ª‚ñ
ƒwƒpƒhƒiƒEƒCƒ‹ƒX‰È # BŒ^ŠÌ‰Š
ƒpƒ|ƒoƒEƒCƒ‹ƒX‰È  
Žå‚ÈRNAƒEƒCƒ‹ƒX ƒpƒ‰ƒ~ƒNƒ\ƒEƒCƒ‹ƒX‰È –ƒ]
ƒIƒ‹ƒgƒ~ƒNƒ\ƒEƒCƒ‹ƒX‰È
iƒIƒ‹ƒ\ƒ~ƒNƒ\ƒEƒCƒ‹ƒX‰Èj
ƒCƒ“ƒtƒ‹ƒGƒ“ƒU
ƒRƒƒiƒEƒCƒ‹ƒX‰È SARS
ƒAƒŒƒiƒEƒCƒ‹ƒX‰È ƒ‰ƒbƒT”M
ƒŒƒgƒƒEƒCƒ‹ƒX‰È # AIDS
ƒtƒBƒƒEƒCƒ‹ƒX‰È  
ƒŒƒIƒEƒCƒ‹ƒX‰È ƒƒ^
ƒsƒRƒ‹ƒiƒEƒCƒ‹ƒX‰È ƒ|ƒŠƒICAŒ^ŠÌ‰Š
ƒJƒŠƒVƒEƒCƒ‹ƒX‰È ƒmƒ
ƒ‰ƒuƒhƒEƒCƒ‹ƒX‰È ‹¶Œ¢•a
ƒtƒ‰ƒrƒEƒCƒ‹ƒX‰È
iƒgƒKƒEƒCƒ‹ƒX‰È‚à“Ž—j
“ú–{”]‰ŠCƒEƒGƒXƒgƒiƒCƒ‹”MCƒfƒ“ƒO”MCCŒ^ŠÌ‰Š
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ƒuƒjƒ„ƒEƒCƒ‹ƒX‰È  

# ŋ߂ÌICTVƒŒƒ|[ƒg‚Å‚ÍCƒwƒpƒhƒiƒEƒCƒ‹ƒX‰È‚ƃŒƒgƒƒEƒCƒ‹ƒX‰È‚ÍCw‹t“]ŽÊ‚ðs‚¤DNA‚¨‚æ‚ÑRNAƒEƒCƒ‹ƒXx‚Æ‚µ‚Ä“¯‚¶ƒJƒeƒSƒŠ‚É•ª—Þ‚³‚ê‚Ä‚¢‚éB




Kawakami Model
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