20,090 Pathway/Genome Databases to Search
BioCyc is a collection of 20,090 Pathway/Genome Databases (PGDBs) covering humans, model eukaryotes, and thousands of microbes. These databases are curated from 167,000 publications. Short two minute video tutorials show what you can do with BioCyc.
BioCyc contains 60+ software tools for searching and analyzing its databases, including a high-speed genome browser and metabolic network viewer.
The databases for E. coli K-12 and Faecalibacterium prausnitzii A2-165 are freely available. Access to the other BioCyc databases requires a paid subscription.
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Learning Library
Tutorial Videos
Tutorial #1: Introduction to BioCyc
Tutorial #2: Introduction to SmartTables
The following Tutorial will guide you through SmartTables, which enable you
to create, upload, share, and analyze sets of genes, metabolites, pathways, and sequence sites.
The Tutorial is broken up into parts, ranging from basic operations to more advanced uses such
as gene expression analysis and metabolomics.
Tutorial #3: Zoomable Metabolic Map, Comparative Tools, Regulatory Network
This tutorial introduces users to many of the advanced tools available on the BioCyc.org website for navigating cellular networks, analyzing large-scale datasets, and comparing organisms.
Tutorial #4: Omics Data Analysis
This tutorial will show you how to use BioCyc's tools for omics data analysis, including the cellular omics viewer, the omics dashboard, and other tools.
Tutorial #5: Pathway Collages
Pathway collages are multi-pathway diagrams that you can customize
by, for example, overlaying omics data, altering the relative
positions of pathways, and modifying connections among pathways.
Learn how to generate, customize and export
high-quality pathway-collage diagrams showing collections of user-specified pathways.
Tutorial #6: Creating a Pathway/Genome Database
Learn the entire process of building a BioCyc-like Pathway/Genome Database (PGDB)
for an organism with a sequenced and annotated
genome. Build a PGDB for your own lab or for the whole scientific community.
- Part 1A: Introduction to Database Building and Pathologic (14:04)
- Part 1B: Building a Database: Detailed Pathologic Example (23:53)
- Part 2A: General Editing Strategies (8:00)
- Part 2B: Creating and Editing Reactions and Compounds (17:32)
- Part 2C: Updating Proteins, Citations, GO Terms, and Enzymatic Reactions (26:10)
- Part 2D: Making and Editing Pathways (9:42)
Tutorial #7: Using the Structured Advanced Query Page
An introduction to the Structured Advanced Query Page, which allows
complex queries and queries across one or more databases in the
BioCyc collection. You'll learn about:The basic steps of setting up an advanced query;
Four examples of increasingly complex queries, including how to query across multiple databases;
Where to learn more about the structure of BioCyc databases.