The dragmacidins represent an emerging class of bioactive marine natural products obtained by an exhaustive set of protocols from a number of deep water sponges including Dragmacidon, Halicortex, ...
Monthly Archives: February 2014
Selective Transformation with Tin Acetal
Characteristics Typically, the 1,2-diol is treated with Bu2SnX, where X = O or (OMe), with removal (azeotropic or desiccant) of either H2O or MeOH to afford the requisite stannylidenes (“tin ...
#6 Prof. Jun Terao: Synthesizing electronic circuits
The sixth interview of this series is with Professor Jun Terao from the Graduate School of Engineering at Kyoto University, as suggested by Professor Kenichiro Itami at our second Chem-Station ...
Ichikawa Allylcyanate Rearrangement
Characteristics Ichikawa Allylcyanate rearrangement is [3.3] sigmatropic rearrangement of allyl cyanates to isocyanate. The rearrangement begins with dehydration of allyl carbamate by Appel ...
Singlet Oxygen
Characteristics Since molecular oxygen exists in a triplet ground state (3O2),the spin conservation rule restricts its transforma- tions to radical-type reactions, which are normally quite ...
Controlling a Polymer Adhesive Using Light and a Molecular Switch
Asadirad, A. M.; Boutault, S.; Erno, Z.; Branda, N. R. J. Am. Chem. Soc. 2014. ASAP DOI: 10.1021/ja500496n A thermally remendable polymer was synthesized by the Diels–Alder reaction between ...
1,3-Dipolar Cycloaddition of Nitrile Oxide
Characteristics Nitrile oxides, R-C≡N+-O- are organic compounds which contain a monovalent functional group -CNO, which bound directly to a carbon atom of the organic moiety of a molecule. Most ...
Photopharmacology: Beyond Proof of Principle
Velema, W. A.; Szymanski, W.; Feringa, B.L. 2014.ASAP (perspective) DOI: 10.1021/ja413063e Pharmacotherapy is often severely hindered by issues related to poor drug selectivity, including side ...
1,3-Dipolar Cycloaddition of Nitrone
Characteristics The 1,3-dipolar cycloaddition of nitrones, a kind of 1,3-dipole to unsaturated (C–C double or triple bond) compounds is one of the useful synthetic method for preparing isoxazole, ...
Trimethylenemethane(TMM) Cycloaddition
Characteristics Trimethylenemethane (TMM) [3 + 2] cycloadditions provide direct routes to functionalized cyclopentanes. This reaction has been shown to be a highly chemo-, regio-, and ...