gain of function mutationsとは 意味・読み方・使い方

The present invention provides analogs of cyclopamine that can be used to counteract the phenotypic effects of unwanted activation of a hedgehog pathway, such as resulting from hedgehog gain-of-function, Ptc loss-of-function or smoothened gain-of-function mutations.例文帳に追加

ヘッジホッグ機能獲得型、Ｐｔｃ機能欠失型、又はスムースンド機能獲得型変異からもたらされるような、ヘッジホッグ経路の不所望の活性化の表現型効果を克服するのに使用し得るシクロパミンの類似体。 - 特許庁

This invention relates to a method for counteracting the phenotypic effects of unwanted activation of a hedgehog pathway, such as resulting from hedgehog gain-of-function, ptc loss-of-function or smoothened gain-of-function mutations by using a steroidal alkaloid or similar object thereof.例文帳に追加

ステロイド系アルカロイド及びそれらの類似体を用いて、ヘッジホッグ機能亢進、ptc機能欠損またはsmoothened機能亢進の突然変異の結果生じる、ヘッジホッグ経路の不必要な活性の表現型作用を抑制する方法。 - 特許庁