hydroxycyclizationとは 意味・読み方・使い方

名詞

hydroxycyclization ‎(複数形 hydroxycyclizations)

1. (有機化学) A reaction in which the addition of a hydroxy group to one carbon atom of a double or triple bond is accompanied by cyclization
   • 2015 June 10, Ruth Dorel, Antonio M. Echavarren, “Gold-Catalyzed Reactions via Cyclopropyl Gold Carbene-like Intermediates”, in The Journal of Organic Chemistry^[1], volume 80, DOI:10.1021/acs.joc.5b01106:

     A transition state similar to TS 34 – 33 has been proposed in the reaction of cyclopropyl gold(I) carbenes generated by retro-Buchner reaction of 7-cyclopropyl 1,3,5-cycloheptatrienes. 79 Gold(I) complexes are able to catalyze the addition of amines, alcohols, or water to 1, n -enynes affording products of amino-, alkoxy-, or hydroxycyclization under much milder conditions than other metal catalysts. 26 , 32 , 33 , 62 , 80 − 82 These additions are stereospecific, as illustrated by the alkoxycyclization of diastereomeric enynes 1m and 1h , and proceed via opening of cyclopropyl gold(I) carbene intermediates 35 by attack of the nucleophile to the cyclopropane ring (Scheme 11 ).