monotransactivatorとは 意味・読み方・使い方

名詞

monotransactivator (複数形 monotransactivators)

1. A monomeric transactivator
   • 2015 August 22, “Modulation of Estrogen Response Element-Driven Gene Expressions and Cellular Proliferation with Polar Directions by Designer Transcription Regulators”, in PLOS ONE‎^[1], DOI:10.1371/journal.pone.0136423:

     Moreover, a model monotransrepressor regulated DNA synthesis, cell cycle progression and proliferation of recombinant adenovirus infected ER-negative cells through decreasing as well as increasing gene expressions with polar directions compared with E2-ERα or monotransactivator.

   • 2015 August 22, “Modulation of Estrogen Response Element-Driven Gene Expressions and Cellular Proliferation with Polar Directions by Designer Transcription Regulators”, in PLOS ONE‎^[2], DOI:10.1371/journal.pone.0136423:

     We previously constructed monomeric transcription activators, or monotransactivators, assembled from an engineered ERE-binding module (EBM) using the ERα-DBD and constitutively active ADs from other transcription factors.