misdifferentiateとは 意味・読み方・使い方

動詞

misdifferentiate (三人称単数 現在形 misdifferentiates, 現在分詞 misdifferentiating, 過去形および過去分詞形 misdifferentiated)

1. To fail to differentiate correctly.
   • 2008, Charles J. Epstein, ‎Robert P. Erickson, ‎Anthony Joseph Wynshaw-Boris, Inborn Errors of Development, page 705:

     In the absence of Mxxl, cranial neural crest-derived mesenchyme consequently fails to proliferate and misdifferentiates (Han et al., 2003a).

   • 2013, Theodoulakis Christofi & Yiorgos Apidianakis, “Drosophila and the Hallmarks of Cancer”, in Andreas Vilcinskas, editor, Yellow Biotechnology I: Insect Biotechnologie in Drug Discovery and Preclinical Research, page 100:

     Sumoylation-deficient Drosophila lesswright mutants have been shown to induce overproduction of hemocytes and form melanotic tumors whereas Ubc9 mutations activate progenitors to misdifferentiate, become hyperplastic, and develop microtumors [172, 173].

   • 2020, Ken-Ichi Furakawa, Shunfu Chin, Toru Asari, Kanichiro Wada, Gentaro Kumagai, & Yasuyuki Ishibashi, “Ectopic Ossification of Human Spinal Ligaments Caused by Mesenchymal Stem Cell Abnormalities”, in Atsushi Okawa, ‎Morio Matsumoto, ‎Motoki Iwasaki, editor, OPLL: Ossification of the Posterior Longitudinal Ligament, page 47:

     Mesenchymal stem cells of patients with ossification are thought to misdifferentiate into osteoblasts instead of target ligament cells because they have high osteogenic ability.