NO328180B1 - Kunstig biologisk implantat og dets bruk og fremgangsmate for redusering av risikoen for dannelse av bindevev etter implantasjon - Google Patents

Kunstig biologisk implantat og dets bruk og fremgangsmate for redusering av risikoen for dannelse av bindevev etter implantasjon Download PDF

Info

Publication number: NO328180B1
Authority: NO; Norway
Prior art keywords: barrier; implant according; semi; permeable; coating
Prior art date: 2003-10-02

Application number

NO20061899A

Other languages

English (en)

Norwegian (no)

Other versions

NO20061899L (no

Inventor

Lars Bruce

Olle Korsgren

Bo Nilsson

Adam Bruce

Original Assignee

Tikomed Ab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-10-02

Filing date

2006-04-28

Publication date

2009-12-28

2006-04-28 Application filed by Tikomed Ab filed Critical Tikomed Ab

2006-06-28 Publication of NO20061899L publication Critical patent/NO20061899L/no

2009-12-28 Publication of NO328180B1 publication Critical patent/NO328180B1/no

Links

239000007943 implant Substances 0.000 title claims abstract description 48
238000000034 method Methods 0.000 title claims abstract description 11
210000002808 connective tissue Anatomy 0.000 title abstract description 17
230000015572 biosynthetic process Effects 0.000 title abstract description 4
238000002513 implantation Methods 0.000 title description 4
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OXCMYAYHXIHQOA-UHFFFAOYSA-N potassium;[2-butyl-5-chloro-3-[[4-[2-(1,2,4-triaza-3-azanidacyclopenta-1,4-dien-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol Chemical compound [K+].CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=2C(=CC=CC=2)C2=N[N-]N=N2)C=C1 OXCMYAYHXIHQOA-UHFFFAOYSA-N 0.000 description 1
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Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/28—Materials for coating prostheses
- A61L27/30—Inorganic materials
- A61L27/306—Other specific inorganic materials not covered by A61L27/303 - A61L27/32
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/022—Artificial gland structures using bioreactors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/28—Materials for coating prostheses
- A61L27/30—Inorganic materials
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Transplantation (AREA)
Animal Behavior & Ethology (AREA)
Oral & Maxillofacial Surgery (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Dermatology (AREA)
Epidemiology (AREA)
Inorganic Chemistry (AREA)
Engineering & Computer Science (AREA)
Vascular Medicine (AREA)
Cardiology (AREA)
Biomedical Technology (AREA)
Heart & Thoracic Surgery (AREA)
Prostheses (AREA)
Materials For Medical Uses (AREA)
External Artificial Organs (AREA)
Apparatus Associated With Microorganisms And Enzymes (AREA)
Slide Fasteners, Snap Fasteners, And Hook Fasteners (AREA)

NO20061899A 2003-10-02 2006-04-28 Kunstig biologisk implantat og dets bruk og fremgangsmate for redusering av risikoen for dannelse av bindevev etter implantasjon NO328180B1 (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
SE0302599A SE526959C2 (sv)	2003-10-02	2003-10-02	Bioartificellt implantat innefattande en semipermeabel barriär samt förfarande för reducering av risken för bildning av bindrväv vid implantatet efter implantering genom att barriären förses med en permeabel beläggning av bioaktiv metall
PCT/SE2004/001418 WO2005030283A1 (en)	2003-10-02	2004-10-04	Bioartificial implant and its use and method of reducing the risk for formation of connective tissue after implantation

Publications (2)

Publication Number	Publication Date
NO20061899L NO20061899L (no)	2006-06-28
NO328180B1 true NO328180B1 (no)	2009-12-28

Family

ID=29247003

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20061899A NO328180B1 (no)	2003-10-02	2006-04-28	Kunstig biologisk implantat og dets bruk og fremgangsmate for redusering av risikoen for dannelse av bindevev etter implantasjon

Country Status (25)

Country	Link
US (1)	US7955613B2 (sr)
EP (1)	EP1667746B1 (sr)
JP (1)	JP4837563B2 (sr)
KR (1)	KR101181535B1 (sr)
CN (1)	CN100536937C (sr)
AT (1)	ATE405301T1 (sr)
AU (1)	AU2004275685B2 (sr)
BR (1)	BRPI0415004A (sr)
CA (1)	CA2539150C (sr)
DE (1)	DE602004016008D1 (sr)
DK (1)	DK1667746T3 (sr)
ES (1)	ES2313072T3 (sr)
IL (1)	IL174488A0 (sr)
MX (1)	MXPA06003665A (sr)
NO (1)	NO328180B1 (sr)
NZ (1)	NZ546775A (sr)
PL (1)	PL1667746T3 (sr)
PT (1)	PT1667746E (sr)
RS (1)	RS20060235A (sr)
RU (1)	RU2349349C2 (sr)
SE (1)	SE526959C2 (sr)
SI (1)	SI1667746T1 (sr)
UA (1)	UA81982C2 (sr)
WO (1)	WO2005030283A1 (sr)
ZA (1)	ZA200602759B (sr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP3537986A4 (en) *	2016-11-10	2020-06-03	ViaCyte, Inc.	PDX1 PANCREATIC ENDODERM CELLS IN CELL INSERTION DEVICES AND METHOD THEREFOR

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SE515227C2 (sv)	1999-04-28	2001-07-02	Bruce Medical Ab	Kropp för åstadkommande av in- och tillväxt av benvävnad och/ eller bindväv och sätt för framställning av kroppen
JP4543152B2 (ja) *	2004-08-20	2010-09-15	独立行政法人産業技術総合研究所	透明チタン被覆生体適合化材料
WO2008103101A1 (en) *	2007-02-19	2008-08-28	Ticapex Ab	Implant assembly
WO2008112190A1 (en) *	2007-03-09	2008-09-18	The University Of Akron	Bio-artificial pancreas and a procedure for preparation of same
CA2698212A1 (en)	2007-08-23	2009-02-26	Intrexon Corporation	Methods and compositions for diagnosing disease
MX2010003371A (es)	2007-09-28	2010-05-05	Intrexon Corp	Constructos interruptores genicos terapeuticos y biorreactores para la expresion de moleculas bioterapeuticas y usos de los mismos.
RU2525737C1 (ru) *	2013-05-22	2014-08-20	Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Саратовский государственный технический университет имени Гагарина Ю.А." (СГТУ имени Гагарина Ю.А.)	Способ изготовления внутрикостного стоматологического имплантата
RU2526252C1 (ru) *	2013-05-30	2014-08-20	Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Саратовский государственный технический университет имени Гагарина Ю.А." (СГТУ имени Гагарина Ю.А.)	Способ изготовления внутрикостных имплантатов с многослойным покрытием
JP7084566B2 (ja) *	2017-05-29	2022-06-15	創生ライフサイエンス株式会社	生体適合性高分子材料のマーキング方法
WO2021061940A1 (en)	2019-09-27	2021-04-01	Isla Technologies, Inc.	Bioartificial pancreas
US12485274B2 (en)	2021-03-08	2025-12-02	Samsung Electronics Co., Ltd.	Apparatus and method with electrical stimulus

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4752292A (en) *	1983-01-24	1988-06-21	Icu Medical, Inc.	Medical connector
SE450623B (sv) *	1984-11-07	1987-07-13	Dan Lundgren	Element for kontrollerad vevnadsinvext i kirurgiskt intervenerade omraden
US5611347A (en) *	1989-07-25	1997-03-18	Smith & Nephew, Inc.	Zirconium oxide and zirconium nitride coated percutaneous devices
FI923023A7 (fi) *	1990-10-31	1992-06-29	Baxter Int	Lähellään tapahtuvan verisuonittumisen aikaansaava istutemateriaali
ATE156344T1 (de)	1991-04-25	1997-08-15	Univ Brown Res Found	Implantierbare, biokompatible immunisolator- trägersubstanz zum abgeben ausgesuchter, therapeutischer produkte
ES2087337T3 (es) *	1991-06-24	1996-07-16	American Cyanamid Co	Composiciones de implantes que contienen una proteina, peptido o polipeptido biologicamente activos.
US5429821A (en)	1992-05-29	1995-07-04	The Regents Of The University Of California	Non-fibrogenic high mannuronate alginate coated transplants, processes for their manufacture, and methods for their use
US5387327A (en) *	1992-10-19	1995-02-07	Duquesne University Of The Holy Ghost	Implantable non-enzymatic electrochemical glucose sensor
RU2040277C1 (ru)	1992-12-27	1995-07-25	Товарищество с ограниченной ответственностью "МиТ" (Медицина и Технология)	Способ изготовления материала для имплантата с электретными свойствами для остеосинтеза
US5876742A (en) *	1994-01-24	1999-03-02	The Regents Of The University Of California	Biological tissue transplant coated with stabilized multilayer alginate coating suitable for transplantation and method of preparation thereof
AUPM425294A0 (en) *	1994-03-04	1994-03-31	Australian National University, The	In-vitro angiogenesis assay
WO1996039993A1 (en)	1995-06-07	1996-12-19	Gore Hybrid Technologies, Inc.	An implantable containment apparatus for a therapeutical device and method for loading and reloading the device therein
US5855613A (en) *	1995-10-13	1999-01-05	Islet Sheet Medical, Inc.	Retrievable bioartificial implants having dimensions allowing rapid diffusion of oxygen and rapid biological response to physiological change
RU2113830C1 (ru)	1996-04-02	1998-06-27	Самарский государственный аэрокосмический университет им.С.П.Королева	Зубной имплантат
RU2109495C1 (ru)	1996-07-19	1998-04-27	Наум Абрамович Иофис	Искусственный клапан сердца и способ его изготовления
RU2117456C1 (ru)	1996-11-18	1998-08-20	Жусев Андрей Иванович	Пластиночный эндооссальный имплантант
RU2162715C2 (ru) *	1997-08-20	2001-02-10	Трофимов Виктор Венедиктович	Состав для покрытия пористых имплантатов
RU2142867C1 (ru)	1998-02-23	1999-12-20	Суслов Анатолий Григорьевич	Комбинированный (режуще-деформирующий) метчик
RU2157245C1 (ru)	1999-03-05	2000-10-10	Антонив Василий Федорович	Способ изготовления имплантатов
AU3724900A (en) *	1999-03-05	2000-09-21	Louis R. Matson	Surface-modified bioactive surgical implants suppressing tissue growth
RU2185127C2 (ru)	1999-07-19	2002-07-20	Нижегородская государственная медицинская академия	Винтовой зубной имплантат
DE19950386A1 (de) *	1999-10-19	2001-05-10	Miladin Lazarov	Biokompatibler Gegenstand
WO2001070379A1 (en) *	2000-03-17	2001-09-27	Koch Membrane Systems, Inc.	Filtration element for severe service applications
EP1280613A4 (en)	2000-04-14	2003-08-27	Virginia Tech Intell Prop	SELF-BUILDING THIN FILM COATING TO IMPROVE THE BIO-COMPATIBILITY OF MATERIALS
RU2191607C2 (ru)	2000-06-23	2002-10-27	Гюнтер Виктор Эдуардович	Носитель клеточных культур искусственных внутренних органов
AU2001273234A1 (en)	2000-07-05	2002-01-14	Islet Technology, Inc.	Method and system for consistent and effective encapsulation of biological material
DK1381402T3 (da)	2001-04-27	2010-03-08	Vivoxid Oy	Fremgangsmåde til forbedring af blødvævsmodtagelse og implantater der gør brug af denne fremgangsmåde
US7163688B2 (en) *	2001-06-22	2007-01-16	Alza Corporation	Osmotic implant with membrane and membrane retention means
SE0200269D0 (sv)	2002-01-31	2002-01-31	Ellem Bioteknik Ab	Material for implantation
US7458991B2 (en) *	2002-02-08	2008-12-02	Howmedica Osteonics Corp.	Porous metallic scaffold for tissue ingrowth

2003
- 2003-10-02 SE SE0302599A patent/SE526959C2/sv not_active IP Right Cessation
2004
- 2004-04-10 UA UAA200604785A patent/UA81982C2/uk unknown
- 2004-10-04 MX MXPA06003665A patent/MXPA06003665A/es active IP Right Grant
- 2004-10-04 KR KR1020067008504A patent/KR101181535B1/ko not_active Expired - Fee Related
- 2004-10-04 US US10/574,114 patent/US7955613B2/en not_active Expired - Fee Related
- 2004-10-04 SI SI200430926T patent/SI1667746T1/sl unknown
- 2004-10-04 DE DE602004016008T patent/DE602004016008D1/de not_active Expired - Lifetime
- 2004-10-04 BR BRPI0415004-0A patent/BRPI0415004A/pt not_active IP Right Cessation
- 2004-10-04 ES ES04775510T patent/ES2313072T3/es not_active Expired - Lifetime
- 2004-10-04 AU AU2004275685A patent/AU2004275685B2/en not_active Ceased
- 2004-10-04 EP EP04775510A patent/EP1667746B1/en not_active Expired - Lifetime
- 2004-10-04 PL PL04775510T patent/PL1667746T3/pl unknown
- 2004-10-04 DK DK04775510T patent/DK1667746T3/da active
- 2004-10-04 ZA ZA200602759A patent/ZA200602759B/en unknown
- 2004-10-04 RS YUP-2006/0235A patent/RS20060235A/sr unknown
- 2004-10-04 JP JP2006532233A patent/JP4837563B2/ja not_active Expired - Fee Related
- 2004-10-04 PT PT04775510T patent/PT1667746E/pt unknown
- 2004-10-04 AT AT04775510T patent/ATE405301T1/de active
- 2004-10-04 CN CNB200480028566XA patent/CN100536937C/zh not_active Expired - Fee Related
- 2004-10-04 WO PCT/SE2004/001418 patent/WO2005030283A1/en not_active Ceased
- 2004-10-04 CA CA2539150A patent/CA2539150C/en not_active Expired - Fee Related
- 2004-10-04 NZ NZ546775A patent/NZ546775A/en not_active IP Right Cessation
- 2004-10-04 RU RU2006114350/15A patent/RU2349349C2/ru not_active IP Right Cessation
2006
- 2006-03-22 IL IL174488A patent/IL174488A0/en not_active IP Right Cessation
- 2006-04-28 NO NO20061899A patent/NO328180B1/no not_active IP Right Cessation

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP3537986A4 (en) *	2016-11-10	2020-06-03	ViaCyte, Inc.	PDX1 PANCREATIC ENDODERM CELLS IN CELL INSERTION DEVICES AND METHOD THEREFOR
US11623023B2 (en)	2016-11-10	2023-04-11	Viacyte, Inc.	PDX1 pancreatic endoderm cells in cell delivery devices and methods thereof
US12144908B2 (en)	2016-11-10	2024-11-19	Viacyte, Inc.	PDX1 pancreatic endoderm cells in cell delivery devices and methods thereof

Also Published As

Publication number	Publication date
JP2007507284A (ja)	2007-03-29
US20060263405A1 (en)	2006-11-23
ZA200602759B (en)	2007-06-27
CN1859934A (zh)	2006-11-08
RU2006114350A (ru)	2007-11-20
SE526959C2 (sv)	2005-11-29
PT1667746E (pt)	2008-11-06
EP1667746B1 (en)	2008-08-20
JP4837563B2 (ja)	2011-12-14
KR20060107753A (ko)	2006-10-16
KR101181535B1 (ko)	2012-09-10
NZ546775A (en)	2008-10-31
ATE405301T1 (de)	2008-09-15
EP1667746A1 (en)	2006-06-14
UA81982C2 (uk)	2008-02-25
IL174488A0 (en)	2006-08-01
SE0302599L (sv)	2005-04-03
DK1667746T3 (da)	2009-01-12
PL1667746T3 (pl)	2009-02-27
RU2349349C2 (ru)	2009-03-20
HK1095542A1 (zh)	2007-05-11
CN100536937C (zh)	2009-09-09
CA2539150C (en)	2013-03-26
ES2313072T3 (es)	2009-03-01
BRPI0415004A (pt)	2006-11-28
US7955613B2 (en)	2011-06-07
AU2004275685A1 (en)	2005-04-07
WO2005030283A1 (en)	2005-04-07
MXPA06003665A (es)	2006-06-05
SI1667746T1 (sl)	2009-02-28
SE0302599D0 (sv)	2003-10-02
AU2004275685B2 (en)	2010-05-13
CA2539150A1 (en)	2005-04-07
DE602004016008D1 (de)	2008-10-02
RS20060235A (sr)	2008-09-29
NO20061899L (no)	2006-06-28

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Date	Code	Title	Description
2013-05-27	MM1K	Lapsed by not paying the annual fees

Publication	Publication Date	Title
EP2125056B1 (en)	2015-11-18	Implant assembly
US5674289A (en)	1997-10-07	Bioartificial pancreas
NO328180B1 (no)	2009-12-28	Kunstig biologisk implantat og dets bruk og fremgangsmate for redusering av risikoen for dannelse av bindevev etter implantasjon
CN105324136B (zh)	2018-11-06	用于组织工程的基质和植入物
US20040247640A1 (en)	2004-12-09	Nitric oxide releasing eptfe coated medical device sandwich
US20060008497A1 (en)	2006-01-12	Implantable apparatus having improved biocompatibility and process of making the same
WO1991000119A1 (en)	1991-01-10	Implantable device
NO309124B1 (no)	2000-12-18	Kunstige biologiske anordninger for frigivelse av hormoner
WO1994003126A1 (en)	1994-02-17	Bioartificial pancreas
US10092387B2 (en)	2018-10-09	Implantable device for retaining live cells and providing nutrients thereto
KR102131101B1 (ko)	2020-07-09	선택적 플라즈마 에칭법에 의한, 혈액적합성이 향상된 ePTFE 인공혈관의 제조방법
KR20010040427A (ko)	2001-05-15	생적합성 이식물용 조성물 및 방법
HK1095542B (en)	2009-12-11	Bioartificial implant and its use and method of reducing the risk for formation of connective tissue after implantation
Wang et al.	2002	A new vascular prosthesis coated with polyamino‐acid urethane copolymer (PAU) to enhance endothelialization
Kulka	2020	Mussel-Inspired Polyglycerol Coatings for the Prevention of Biomaterial-Related Fouling
Richardson et al.	1980	Hybrid organs
Busscher et al.	1992	Biomaterials Biocompatibility in Health Problems
BUSSCHER¹ et al.	1992	Materia Technica¹ and Biomedical Technology Centre²