NZ619215B2 - Method for filling bone cavities with calcium - Google Patents

Abstract

method and medicament is disclosed for filling cavity formations in metaphyseal (trabecular) bone sections with calcium and for preventing secretion of calcium therefrom. The proposed method consists in supplying drone brood to an organism in combination with supplying calcium to the organism.

Description

A METHOD FOR FILLING BONE CAVITIES WITH CALCIUM The invention relates generally to medicine. Disclosed herein are methods for combating the effects of calcium deficiency in the skeletal system of the body, which manifests in the form of an increase in the quantity and size of cavities in metaphyseal (trabecular) bone sections and for preventing such manifestations of calcium deficiency.

The existing methods for preventing and treating calcium deficiency in the body aim to saturate bone tissue with calcium. To that end, various calcium-containing preparations as well as vitamin D and hormonal preparations (such as testosterone) are used.

These methods have a number of significant disadvantages. Although calcium is not a toxic substance and no maximum allowable doses for administration have been established for it, prolonged use of significant quantities of calcium may increase the risk of stroke. When calcium preparations are being used, calcium can be supplied to other organs and systems as well as to bones, and in particular, can calcify calculi in the kidneys, which in turn leads to kidney function issues.

Similarly, there is a risk of exceeding the safe quantity of vitamin D in the body. In several cases the use of hormonal preparations is undesirable or completely excluded for medical reasons. Artificially increasing testosterone in females (even for apparently healthy females) is generally undesirable. It is also important to consider the fact that using calcium- containing preparations either separately or in combination with vitamins and/or hormones, in addition to all of the above-mentioned side effects and contra-indications, only makes it possible to increase mineralisation of bone tissue. Existent and newly-formed cavities in metaphyseal (trabecular) bone sections remain unchanged or the quantity and sizes thereof may continue to increase. These cavities reduce bone strength and increase the risk of injury at various loads.

While the applicant regularly takes part in research in this field, they are unaware of any methods that would provide for the desired result.

The current methods for increasing the calcium content in bone tissue in the body makes it possible to increase bone mineralisation but not to fill cavities therein and/or to at least provide the public with a useful choice.

The proposed solution aims to reduce and eliminate, where possible, existing cavities and to keep new cavities from forming. The desired result is achieved by providing for the supply of drone brood in combination with calcium to a body.

As experiments have shown, regular drone brood treatment in combination with supplying calcium to a body provides for the desired results.

Accordingly, in one aspect, the invention relates to the use of drone brood and at least one calcium compound for the preparation of a medicament for filling cavities in metaphyseal bone sections with calcium or for preventing the secretion of calcium therefrom.

In another aspect the invention relates to a combination comprising drone brood and at least one calcium-containing preparation for use in filling cavities in metaphyseal bone sections with calcium or in preventing secretion of calcium therefrom.

Also described herein is the use of a combination comprising drone brood and at least one calcium-containing preparation in the manufacture of a medicament for filling cavities in metaphyseal bone sections with calcium or for prevention of secretion of calcium therefrom.

Certain statements that appear below are broader than what appears in the statements of the invention above. These statements are provided in the interests of providing the reader with a better understanding of the invention and its practice. The reader is directed to the accompanying claim set which defines the scope of the invention.

Figure 1 shows the result of an X-ray examination prior to the commencement of treatment.

Two black cavities can be seen at the top and at the bottom of the bone.

Figure 2 shows the results of an X-ray examination after a course of treatment. The cavities have been filled and have become blue.

The research was carried out using an X-ray absorption method on NORLAND, OSTEOMETR DTX-100 and 200 apparatuses on a group of 10,000 patients.

The calcium in the cavities is predominantly in the form of calcium hydroxyapatite.

In addition to providing for the supply of calcium to the body in common food products, various calcium-containing preparations can be used including calcium carbonate, calcium citrate, calcium gluconate, calcium aspartate, calcium ascorbate, calcium amino chelate, calcium fumarate, calcium succinate, calcium phosphate, and calcium citrate, any one of these or any combination thereof.

During the experimental confirmation of the results, drone brood was given to patients orally in powder form, tablet form or capsule form either as the individual active agent or in combination with calcium-containing compounds.

The desired result can be achieved more quickly or more slowly depending on the individual properties of a particular body, the amount of calcium required in food and the quantity and size of the cavities, but the result is achieved in any case. It has been seen that 100% of patients achieved practically significant results over an extended course of treatment (nine months).

The term “comprising” as used in this specification and claims means “consisting at least in part of”. When interpreting statements in this specification, and claims which include the term “comprising”, it is to be understood that other features that are additional to the features prefaced by this term in each statement or claim may also be present. Related terms such as “comprise” and “comprised” are to be interpreted in similar manner.

Claims (8)

Claims 1.

1. Use of drone brood and at least one calcium compound for the preparation of a medicament for filling cavities in metaphyseal bone sections with calcium or for preventing the secretion of calcium therefrom.

2. The use according to claim 1, wherein the drone brood is in the form of a powder, a tablet or a capsule.

3. The use according to claim 1 or 2, wherein the calcium compound is selected from the group consisting of: calcium carbonate, calcium gluconate, calcium aspartate, calcium ascorbate, calcium amino chelate, calcium fumarate, calcium succinate, calcium phosphate, and calcium citrate.

4. A combination comprising drone brood and at least one calcium-containing preparation for use in filling cavities in metaphyseal bone sections with calcium or in preventing secretion of calcium therefrom.

5. The combination according to claim 4, wherein the drone brood is in the form of a powder, a tablet or a capsule.

6. The combination according to claim 4 or 5, wherein the calcium-containing preparation comprises a calcium compound selected from the group consisting of: calcium carbonate, calcium gluconate, calcium aspartate, calcium ascorbate, calcium amino chelate, calcium fumarate, calcium succinate, calcium phosphate, and calcium citrate.

7. A use as defined in claim 1 substantially as herein described with reference to any example thereof.

8. A combination as defined in claim 4 substantially as herein described with reference to any example thereof.