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NZ721213B2 - Anti-trop2 antibody-drug conjugate - Google Patents
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NZ721213B2 - Anti-trop2 antibody-drug conjugate - Google Patents

Anti-trop2 antibody-drug conjugate

Info

Publication number
NZ721213B2
NZ721213B2 NZ721213A NZ72121314A NZ721213B2 NZ 721213 B2 NZ721213 B2 NZ 721213B2 NZ 721213 A NZ721213 A NZ 721213A NZ 72121314 A NZ72121314 A NZ 72121314A NZ 721213 B2 NZ721213 B2 NZ 721213B2
Authority
NZ
New Zealand
Prior art keywords
drug conjugate
trop2 antibody
antibody
bonds
trop2
Prior art date
Application number
NZ721213A
Other versions
NZ721213A (en
Inventor
Toshinori Agatsuma
Hirofumi Hamada
Jun Hasegawa
Daisuke Okajima
Shu Takahashi
Miki Yamaguchi
Original Assignee
Daiichi Sankyo Company Limited
Sapporo Medical University
Filing date
Publication date
Application filed by Daiichi Sankyo Company Limited, Sapporo Medical University filed Critical Daiichi Sankyo Company Limited
Priority to NZ760379A priority Critical patent/NZ760379A/en
Priority claimed from PCT/JP2014/006421 external-priority patent/WO2015098099A1/en
Publication of NZ721213A publication Critical patent/NZ721213A/en
Publication of NZ721213B2 publication Critical patent/NZ721213B2/en

Links

Classifications

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    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
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    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3053—Skin, nerves, brain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3069—Reproductive system, e.g. ovaria, uterus, testes, prostate
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/77—Internalization into the cell
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Abstract

Provided is an antibody-drug conjugate comprising an antitumor exatecan derivative and an anti-TROP2 antibody, which are linked via a linker having a structure represented by the formula -L1-L2-LP-NH-(CH2)n1-La-(CH2)n2-C(=O)- . The anti-TROP2 antibody bonds with the L1 terminal and the antitumor compound bonds with the carbonyl group of the -(CH2)n2-C(=O)- moiety using the nitrogen atom of the amino group at position 1 as the bonding site).

Claims (1)

1. Claims D
NZ721213A 2013-12-25 2014-12-24 Anti-trop2 antibody-drug conjugate NZ721213B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
NZ760379A NZ760379A (en) 2013-12-25 2014-12-24 Anti-trop2 antibody-drug conjugate

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2013267548 2013-12-25
PCT/JP2014/006421 WO2015098099A1 (en) 2013-12-25 2014-12-24 Anti-trop2 antibody-drug conjugate

Publications (2)

Publication Number Publication Date
NZ721213A NZ721213A (en) 2022-12-23
NZ721213B2 true NZ721213B2 (en) 2023-03-24

Family

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