NZ745184B2 - 3-(carboxymethyl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives - Google Patents
3-(carboxymethyl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives Download PDFInfo
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- NZ745184B2 NZ745184B2 NZ745184A NZ74518417A NZ745184B2 NZ 745184 B2 NZ745184 B2 NZ 745184B2 NZ 745184 A NZ745184 A NZ 745184A NZ 74518417 A NZ74518417 A NZ 74518417A NZ 745184 B2 NZ745184 B2 NZ 745184B2
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- methyl
- diazaspiro
- cis
- cyclobutyl
- decanyl
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- MOJKNJJMFNBZEP-UHFFFAOYSA-N 2-(8-amino-2-oxo-1,3-diazaspiro[4.5]decan-3-yl)acetic acid Chemical class C(=O)(O)CN1C(NC2(C1)CCC(CC2)N)=O MOJKNJJMFNBZEP-UHFFFAOYSA-N 0.000 title 1
- 239000003814 drug Substances 0.000 claims abstract 3
- 125000002704 decyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 197
- -1 [1-(Cyclobutyl-methyl)dimethylaminooxophenyl-1,3-diazaspiro[4.5]decanyl]-N-[2-[2- [2-[2-[2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxy]-ethoxy]-ethoxy]-ethoxy]-ethyl]-acetamide Chemical compound 0.000 claims 87
- 229920006395 saturated elastomer Polymers 0.000 claims 60
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 32
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 31
- DIOQZVSQGTUSAI-UHFFFAOYSA-N decane Chemical compound CCCCCCCCCC DIOQZVSQGTUSAI-UHFFFAOYSA-N 0.000 claims 24
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 22
- 125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 claims 21
- JDPQWHLMBJZURR-UHFFFAOYSA-N decan-5-one Chemical compound CCCCCC(=O)CCCC JDPQWHLMBJZURR-UHFFFAOYSA-N 0.000 claims 18
- ZAJNGDIORYACQU-UHFFFAOYSA-N methyl n-octyl ketone Natural products CCCCCCCCC(C)=O ZAJNGDIORYACQU-UHFFFAOYSA-N 0.000 claims 18
- 125000001424 substituent group Chemical group 0.000 claims 18
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 17
- 125000003118 aryl group Chemical group 0.000 claims 15
- 125000000753 cycloalkyl group Chemical group 0.000 claims 15
- 125000006163 5-membered heteroaryl group Chemical group 0.000 claims 13
- 150000001875 compounds Chemical class 0.000 claims 13
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 7
- 229910052757 nitrogen Inorganic materials 0.000 claims 7
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 7
- DLFVBJFMPXGRIB-UHFFFAOYSA-N thioacetamide Natural products CC(N)=O DLFVBJFMPXGRIB-UHFFFAOYSA-N 0.000 claims 7
- 125000004850 cyclobutylmethyl group Chemical group C1(CCC1)C* 0.000 claims 5
- 150000003839 salts Chemical class 0.000 claims 5
- 229940080818 propionamide Drugs 0.000 claims 4
- DXJKRLHHCGXHMB-UHFFFAOYSA-N 5,6,7,8-tetrahydro-[1,2,4]triazolo[1,5-a]pyrazine Chemical compound C1NCCN2N=CN=C21 DXJKRLHHCGXHMB-UHFFFAOYSA-N 0.000 claims 2
- 125000001072 heteroaryl group Chemical group 0.000 claims 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- 125000006652 (C3-C12) cycloalkyl group Chemical group 0.000 claims 1
- 125000006707 (C3-C12) heterocycloalkyl group Chemical group 0.000 claims 1
- 125000004206 2,2,2-trifluoroethyl group Chemical group [H]C([H])(*)C(F)(F)F 0.000 claims 1
- QKYYCHBWOLRIJJ-UHFFFAOYSA-N 2-pyrimidin-2-ylacetamide Chemical compound NC(=O)CC1=NC=CC=N1 QKYYCHBWOLRIJJ-UHFFFAOYSA-N 0.000 claims 1
- XJXBWJFUCWOLSY-UHFFFAOYSA-N 4-methoxybutanamide Chemical compound COCCCC(N)=O XJXBWJFUCWOLSY-UHFFFAOYSA-N 0.000 claims 1
- 101100347605 Arabidopsis thaliana VIII-A gene Proteins 0.000 claims 1
- 101100347612 Arabidopsis thaliana VIII-B gene Proteins 0.000 claims 1
- OHLUUHNLEMFGTQ-UHFFFAOYSA-N N-methylacetamide Chemical compound CNC(C)=O OHLUUHNLEMFGTQ-UHFFFAOYSA-N 0.000 claims 1
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 claims 1
- 238000013329 compounding Methods 0.000 claims 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 1
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 125000001207 fluorophenyl group Chemical group 0.000 claims 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
- 125000002883 imidazolyl group Chemical group 0.000 claims 1
- 125000000250 methylamino group Chemical group [H]N(*)C([H])([H])[H] 0.000 claims 1
- 125000002816 methylsulfanyl group Chemical group [H]C([H])([H])S[*] 0.000 claims 1
- 125000006216 methylsulfinyl group Chemical group [H]C([H])([H])S(*)=O 0.000 claims 1
- 125000004193 piperazinyl group Chemical group 0.000 claims 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
Abstract
The invention relates to 3-(carboxymethyl)-8-amino-2-oxo-l,3-diaza- spiro-[4.5]-decane derivatives of general formula (I), their preparation and their use in medicine, particularly in the treatment of pain.
Claims (15)
1. A compound according to general formula (I) R 13 16 R 10 R 9 R 14 R 15 R R 12 R 1 5 N R N R 2 O R 3 R 4 R 18 R 19 R 17 R 20 wherein R1 and R2 independently of one another mean -C1-C6-alkyl, linear or branched, saturated or unsaturated, tituted or substituted with one, two, three or four substituents independently of one another selected from the group consisting of -F, -Cl, -Br, -I, - OH, -OCH3, -CN and 3; a 3membered cycloalkyl moiety, saturated or unsaturated, unsubstituted or substituted with one, two, three or four substituents independently of one another selected from the group consisting of -F, -Cl, -Br, - I, -OH, -OCH3, -CN and -CO2CH3; wherein said 3membered lkyl moiety is optionally connected through -C1-C6-alkylene-, linear or branched, saturated or unsaturated, unsubstituted; or a 3membered heterocycloalkyl moiety, saturated or unsaturated, unsubstituted or substituted with one, two, three or four substituents independently of one another selected from the group consisting of -F, -Cl, -Br, -I, -OH, -OCH3, -CN and -CO2CH3; wherein said 3 membered heterocycloalkyl moiety is ally connected through -C1-C6-alkylene-, linear or ed, saturated or unsaturated, unsubstituted; R1 and R2 together with the nitrogen atom to which they are attached form a ring and mean -(CH2)3; - (CH2)2-O-(CH2)2-; or -(CH2)2-NRA-(CH2)2-, wherein RA means -H or -C1-C6-alkyl, linear or branched, saturated or unsaturated, unsubstituted or substituted with one, two, three or four substituents independently of one another ed from the group consisting of -F, -Cl, -Br and -I; R3 means -C1-C6-alkyl, linear or ed, saturated or unsaturated, tituted, mono- or polysubstituted; a embered cycloalkyl moiety, saturated or unsaturated, unsubstituted, mono- or polysubstituted; wherein said 3membered cycloalkyl moiety is optionally connected through -C1-C6-alkylene-, linear or ed, saturated or rated, unsubstituted, mono- or polysubstituted; a 3membered heterocycloalkyl moiety, saturated or unsaturated, unsubstituted, mono- or polysubstituted ; n said 3membered heterocycloalkyl moiety is ally connected through -C1-C6- alkylene-, linear or branched, saturated or rated, unsubstituted, mono- or polysubstituted; a 6membered aryl moiety, unsubstituted, mono- or polysubstituted; wherein said 6membered aryl moiety is optionally connected through -C1-C6-alkylene-, linear or branched, saturated or unsaturated, unsubstituted, mono- or polysubstituted; or a 5membered heteroaryl moiety, unsubstituted, mono- or polysubstituted; wherein said 5membered heteroaryl moiety is ally connected through -C1-C6-alkylene-, linear or branched, saturated or unsaturated, unsubstituted, mono- or polysubstituted; R4 means -C1-C6-alkyl, linear or branched, saturated or unsaturated, tituted, mono- or polysubstituted; wherein said -C1-C6-alkyl is optionally connected through -C(=O)-, -C(=O)O-, or -S(=O)2-; a 3membered cycloalkyl moiety, saturated or unsaturated, unsubstituted, mono- or bstituted; wherein said 3membered cycloalkyl moiety is optionally connected through -C1-C6-alkylene-, linear or branched, saturated or unsaturated, unsubstituted, mono- or polysubstituted; or n said 3 membered cycloalkyl moiety is optionally ted through -C(=O)-, -C(=O)O-, -C(=O)O-CH2-, or - S(=O)2-; a 3membered heterocycloalkyl , saturated or unsaturated, unsubstituted, mono- or polysubstituted ; wherein said 3membered heterocycloalkyl moiety is ally connected through -C1-C6- alkylene-, linear or branched, saturated or unsaturated, unsubstituted, mono- or polysubstituted; or wherein said 3membered heterocycloalkyl moiety is optionally connected through -C(=O)-, -C(=O)O-, - C(=O)O-CH2-, or -S(=O)2-; a 6membered aryl moiety, unsubstituted, mono- or polysubstituted; wherein said 6membered aryl moiety is optionally connected through -C1-C6-alkylene-, linear or branched, saturated or unsaturated, unsubstituted, mono- or polysubstituted; or n said embered aryl moiety is optionally connected through -C(=O)-, -C(=O)O-, -C(=O)O-CH2-, or -S(=O)2-; or a 5membered aryl moiety, unsubstituted, mono- or polysubstituted; wherein said embered heteroaryl moiety is optionally connected through -C1-C6-alkylene-, linear or branched, saturated or unsaturated, unsubstituted, mono- or bstituted; or wherein said 5membered heteroaryl moiety is optionally connected through -, -C(=O)O-, -C(=O)O-CH2-, or 2-; X means -O-, -S- or -NR6-; R5 means -C1-C6-alkyl, linear or branched, saturated or rated, unsubstituted, mono- or polysubstituted; a 3membered cycloalkyl moiety, saturated or unsaturated, unsubstituted, mono- or polysubstituted; wherein said 3membered cycloalkyl moiety is optionally connected through -C1-C6-alkylene-, linear or branched, ted or unsaturated, unsubstituted, mono- or bstituted; a 3membered heterocycloalkyl moiety, saturated or unsaturated, unsubstituted, mono- or polysubstituted ; wherein said 3membered heterocycloalkyl moiety is optionally connected through -C1-C6- alkylene-, linear or ed, saturated or unsaturated, unsubstituted, mono- or polysubstituted; a embered aryl moiety, unsubstituted, mono- or polysubstituted; wherein said 6membered aryl moiety is optionally connected through -C1-C6-alkylene-, linear or branched, saturated or rated, unsubstituted, mono- or polysubstituted; or a 5membered heteroaryl moiety, unsubstituted, mono- or polysubstituted; wherein said 5membered heteroaryl moiety is optionally ted through -C1-C6-alkylene-, linear or branched, saturated or rated, unsubstituted, mono- or polysubstituted; in case X means NR6, R6 means -C1-C6-alkyl, linear or branched, saturated or unsaturated, unsubstituted, mono- or polysubstituted; a 3membered cycloalkyl , saturated or unsaturated, unsubstituted, mono- or polysubstituted; wherein said 3membered cycloalkyl moiety is optionally connected through -C1-C6-alkylene-, linear or branched, ted or unsaturated, tituted, mono- or polysubstituted; a 3membered heterocycloalkyl moiety, saturated or unsaturated, unsubstituted, mono- or polysubstituted ; wherein said 3membered heterocycloalkyl moiety is optionally connected through -C1-C6- alkylene-, linear or branched, saturated or unsaturated, unsubstituted, mono- or polysubstituted; a 6membered aryl moiety, tituted, mono- or polysubstituted; wherein said embered aryl moiety is optionally connected through -C1-C6-alkylene-, linear or branched, saturated or unsaturated, unsubstituted, mono- or polysubstituted; or a 5membered heteroaryl moiety, unsubstituted, mono- or bstituted; wherein said 5membered heteroaryl moiety is optionally connected through -C1-C6-alkylene-, linear or ed, saturated or unsaturated, tituted, mono- or polysubstituted; or in case X means NR6, R5 and R6 together with the nitrogen atom to which they are attached form a 3- 12-membered heterocycloalkyl moiety, saturated or unsaturated, unsubstituted, mono- or polysubstituted; R9, R10, R11, R12, R13, R14, R15, R16, R17, R18, R19, and R20 independently of one another mean -H, -F, -Cl, -Br, -I, -OH, or -C1-C6-alkyl, linear or branched, saturated or unsaturated, unsubstituted, mono- or polysubstituted; wherein "mono- or polysubstituted" means that one or more hydrogen atoms are replaced by a substituent independently of one another ed from the group consisting of -F, -Cl, -Br, -I, -CN, -R21, -C(=O)R21, -C(=O)OR21, -C(=O)NR21R22, -O-(CH2CH2-O)1H, -O-(CH2CH2-O)1CH3, =O, -OR21, -OC(=O)R21, - OC(=O)OR21, -OC(=O)NR21R22, -NO2, -NR21R22, -NR21-(CH2)1C(=O)R22, -NR21-(CH2)1C(=O)OR22, -NR23-(CH2)1C(=O)NR21R22, -NR21C(=O)R22, -NR21C(=O)-OR22, -NR23C(=O)NR21R22, - NR21S(=O)2R22, -SR21, -S(=O)R21, -S(=O)2R21, -S(=O)2OR21, and -S(=O)2NR21R22; wherein R21, R22 and R23 independently of one another mean -C1-C6-alkyl, linear or ed, saturated or unsaturated, unsubstituted or substituted with one, two, three or four substituents independently of one another selected from the group consisting of -F, -Cl, -Br, -I, - CN, -OH, -NH2, and -O-C1-C6-alkyl; a 3membered cycloalkyl moiety, ted or unsaturated, unsubstituted; wherein said 3membered lkyl moiety is optionally connected through -C1-C6-alkylene-, linear or branched, saturated or unsaturated, tituted or substituted with one, two, three or four substituents independently of one another selected from the group consisting of -F, -Cl, -Br, -I, -CN, -OH, -NH2, -C1-C6-alkyl and -O-C1-C6- alkyl; a 3membered heterocycloalkyl moiety, saturated or unsaturated, unsubstituted; wherein said 3 membered heterocycloalkyl moiety is optionally connected through -C1-C6-alkylene-, linear or ed, saturated or rated, unsubstituted or tuted with one, two, three or four substituents independently of one another selected from the group consisting of -F, -Cl, -Br, -I, -CN, -OH, -NH2, -C1-C6-alkyl and -OC1-C6-alkyl a 6membered aryl moiety, unsubstituted, mono- or polysubstituted; wherein said 6membered aryl moiety is optionally connected through -C1-C6-alkylene-, linear or ed, saturated or unsaturated, unsubstituted or substituted with one, two, three or four substituents independently of one another selected from the group consisting of -F, -Cl, -Br, -I, -CN, -OH, -NH2, -alkyl and -O-C1-C6-alkyl; a 5membered heteroaryl moiety, unsubstituted, mono- or polysubstituted; wherein said 5membered heteroaryl moiety is optionally connected h -C1-C6-alkylene-, linear or ed, saturated or unsaturated, unsubstituted or substituted with one, two, three or four substituents independently of one another selected from the group ting of -F, -Cl, -Br, -I, -CN, -OH, -NH2, -C1-C6-alkyl and -O-C1-C6- alkyl; or R21 and R22 within NR21R22, -OC(=O)NR21R22, -NR21R22, -NR23-(CH2)1C(=O)NR21R22, - NR23C(=O)NR21R22, or -S(=O)2NR21R22 together with the nitrogen atom to which they are attached form a ring and mean -(CH2)3; -(CH2)2-O-(CH2)2-; or -(CH2)2-NRB-(CH2)2-, wherein RB means -H or -C1-C6- alkyl, linear or branched, saturated or unsaturated, unsubstituted or substituted with one, two, three or four substituents independently of one another selected from the group consisting of -F, -Cl, -Br and -I; or a physiologically acceptable salt thereof.
2. The compound according to claim 1, wherein R9, R10, R11, R12, R13, R14, R15, R16, R17, R18, R19, and R20 independently of one another mean -H, -F, -OH, or -C1-C6-alkyl.
3. The compound ing to claim 1 or 2, wherein (i) R1 means -H; and R2 means -C1-C6-alkyl, linear or branched, saturated or unsaturated, unsubstituted, mono- or polysubstituted; or (ii) R1 means -CH3; and R2 means -C1-C6-alkyl, linear or branched, saturated or unsaturated, unsubstituted, mono- or polysubstituted; or (iii) R1 means -H or -CH3; and wherein R2 means -CH2-cycloalkyl, -CH2-cyclobutyl, -CH2-cyclopentyl, -CH2-oxetanyl or -CH2-tetrahydrofuranyl; or (iv) R1 and R2 together with the nitrogen atom to which they are attached form a ring and mean -(CH2)3.
4. The compound according to any one of the preceding claims, wherein (i) R3 means -C1-C6-alkyl, linear or branched, saturated or unsaturated, unsubstituted, mono- or polysubstituted; or (ii) R3 means a 6membered aryl moiety, unsubstituted, mono- or polysubstituted; or (iii) R3 means a 5membered heteroaryl moiety, tituted, mono- or polysubstituted.
5. The compound according to any one of the preceding claims, wherein (i) R4 means -H; or (ii) R4 means -C1-C6-alkyl, linear or branched, saturated or rated, unsubstituted, mono- or polysubstituted; or (iii) R4 means a 3membered cycloalkyl moiety, saturated or rated, unsubstituted, mono- or polysubstituted; wherein the 3membered cycloalkyl moiety is connected through -C1-C6-alkylene-, linear or branched, saturated or unsaturated, unsubstituted, mono- or bstituted; or (iv) R4 means a 3membered heterocycloalkyl moiety, ted or unsaturated, unsubstituted, mono- or bstituted; wherein said 3membered heterocycloalkyl moiety is connected through -alkylene-, linear or branched, saturated or unsaturated, unsubstituted, mono- or polysubstituted; or (v) R4 means a embered aryl moiety, unsubstituted, mono- or polysubstituted; wherein said 6membered aryl moiety is connected through -C1-C6-alkylene-, linear or branched, saturated or unsaturated, unsubstituted, mono- or polysubstituted; or (vi) R4 means a 5membered heteroaryl moiety, unsubstituted, mono- or polysubstituted; wherein said 5membered heteroaryl moiety is connected through -C1-C6-alkylene-, linear or branched, saturated or unsaturated, unsubstituted, monoor polysubstituted.
6. The nd according to any one of the ing , wherein R5 means -H.
7. The compound according to any one of claims 1 to 5, wherein (i) R5 means -C1-C6-alkyl, linear or branched, saturated or unsaturated, unsubstituted, mono- or polysubstituted; or (ii) R5 means a 3membered cycloalkyl moiety, saturated or unsaturated, unsubstituted, mono- or polysubstituted, wherein said 3 membered cycloalkyl moiety is optionally connected h -C1-C6-alkylene-, linear or branched, saturated or unsaturated, tituted, mono- or polysubstituted; or (iii) R5 means a 3membered heterocycloalkyl , saturated or unsaturated, unsubstituted, mono- or polysubstituted; wherein said 3- 12-membered cycloalkyl moiety is optionally connected through -C1-C6-alkylene-, linear or branched, saturated or unsaturated, unsubstituted, mono- or polysubstituted; or (iv) R5 means a 5 membered heteroaryl moiety, unsubstituted, mono- or polysubstituted; wherein said embered heteroaryl moiety is ally connected h -C1-C6-alkylene-, linear or branched, saturated or unsaturated, unsubstituted, mono- or polysubstituted.
8. The compound according to any one of the preceding claims, wherein (i) X means NR6 and R5 and R6 together with the nitrogen atom to which they are attached form a 3membered heterocycloalkyl , saturated or unsaturated, unsubstituted, mono- or polysubstituted; or (ii) NR6 and R6 means -H or -C1-C6- alkyl, linear or branched, saturated or unsaturated, unsubstituted, mono- or polysubstituted.
9. The compound according to any one of the preceding claims, which has a structure according to any of general formulas (II-A) to (VIII-C): X X 5 N 2 5 NH R N R R N O O N N O O R 4 R 4 R D D (II-A) (II-B) R R 5 N R 2 R5 O R 3 (II-C) RD R C X X 5 N N R N R 5 N O R 3 O R 3 N N O O R R C (III-C) (III-B) R1 R 1 X X R5 N R2 5 N R N O R3 O R 3 N N O O -3 (CH 2) 2 - 3 H3CO H 3CO (IV-A) (IV-B) N R 5 N N R 2 R5 N O R3 N N O (CH2)2-3 H3CO R C (IV-C) (V-A) X X R5 N R 5 N O O N N O O RD R (V-C) (V-B) N X R 5 N R 2 N R 5 N O O N N O O (CH 2) 2 - 3 (CH 2) 2 - 3 D R D H 3CO R H 3CO (VI-A) (VI-B) X X N R 5 N 2 R 5 N N R O N N O (CH 2) 2 - 3 R D R D H 3CO (VI-C) (VII-A) N X R5 N R 5 N O O N N O O (VII-C) (VII-B) R1 R 1 X X R5 N R2 R 5 N O O N N O H O H (VIII-A) (VIII-B) RD RD R 5 N O H (VIII-C) wherein in each case R1, R2, R3, R4, R5, R6 and X are d as in any one of the preceding claims, RC means -H, -OH, -F, -CN or -C1-C4-alkyl; RD means -H or -F; or a physiologically acceptable salt thereof.
10. The compound according to any one of the preceding claims, n the substructure R 10 R 9 has a meaning selected from the group consisting of: H H2N N N O O H 2N H O O N N H 2N N O O O O N N N H 2N O O N N H 2N H O O N N N N O O N N N O O O H2NOC O H H N N OH O O O H HO O O O O H H N N O O N H H H N N OH O O H H N N OH OH O O H N N S N O O N H H N N N S O N O H N N N N O O N S N N O N HO N N O O 2S O OH O N H O O N O H H N N HO HO O O N N HO HO O O H H NC N N O O H O 2 H N S N S N O 2 H O O H H N H N O O 1-30 1-30 O O N N H N O O HO O N O N N N N O N O O N N H O N N O N N O H H N N N O N O H O N NC N N N N O N O H H N N N N N O N O N OH N N O N O N H H N N N N O O HO N N H H NC N N N N O O NC N H N N O N N O H H O N N N O N O N O N H H N N N O N O N N N N H H 3CO 2C N N CO 2CH 3 N N N N H 3CO 2C CONH 2 H H N N N N O O CO2CH3 CONHCH 3 H H N N N N N N H H2NOC N N H2NOC N N N N H O N O N N N O H H N N N O O O N O N N H N O N N NC N N N N N N NC O N N H N O F F H N N F N H H N N N O O N F N N N O N O H H N N N O O N H N N N O N N H N N N N H H N N N O O N N H O 2S N N H N N OS N N N N H S N N H N N N OH N H H N N HO N N O O N H N N O O H H N N N N O O H H N N N O O N N H N N O O H H N N N O N O O O H H N N N N N O O H H N N N N O O N H N N N N N N H N N N N O H3CO2S N N N O O S H 2NOC H 3CO 2S N N O O
11. The compound according to any one of the preceding claims, wherein R1 means -H or -CH3; R2 means -CH3, -CH2CH3 or -CH2-C(H)(CH3)2; R3 means -phenyl, yl or -pyridinyl, in each case unsubstituted or bstituted with -F; R4 means -C1-C6-alkyl, linear or branched, saturated, unsubstituted or substituted with one, two, three or four substituents independently of one another selected from the group consisting of -F, -Cl, -Br, -I, -CN, -OH, =O, -N(CH3)2 and -O-CH3; or propyl, butyl, -cyclopentyl or -cyclohexyl, unsubstituted or monosubstituted with -F, -OH, - CN or -CH3, wherein said -cyclopropyl, -cyclobutyl, -cyclopentyl or -cyclohexyl is connected through - CH2- or -CH2CH2-; -oxetanyl unsubstituted or monosubstituted with -F, -OH, -CN or -CH3, wherein said -oxetanyl is connected through -CH2- or -CH2CH2-; X means -O- or -NR6-; R5 means -C1-C6-alkyl, linear or branched, saturated or unsaturated, unsubstituted or substituted with one, two, three or four substituents independently of one another selected from the group consisting of -F, -Cl, -Br, -I, - CN, -O-CH3, 2-CH2-O)1H, -O-(CH2CH2-O)1CH3, -C(=O)OH, OCH3, -C(=O)NH2, - C(=O)NHCH3, -C(=O)N(CH3)2, -OH, -S(=O)CH3, -S(=O)2CH3, unsubstituted -C(=O)-morpholinyl, -NHC (=O)-CH3, -N(CH3)2 and NH-S(=O)2-CH3; -cyclopropyl, -cyclobutyl, -cyclopentyl or -cyclohexyl, unsubstituted or bstituted with -F, -OH, - CN or -CH3, n said -cyclopropyl, -cyclobutyl, cyclopentyl or cyclohexyl is ally connected through -CH2- or -CH2CH2-; -heterocyclobutyl, -heterocyclopentyl, or -heterocyclohexyl, in each case unsubstituted or substituted with one, two, three or four substituents independently of one another selected from the group consisting of -F, -Cl, -Br, -I, -CN, -O-CH3, -O-(CH2-CH2-O)1H, 2CH2-O)1CH3, -alkyl, -C(=O)OH, - C(=O)OCH3, NH2, -C(=O)NHCH3, -C(=O)N(CH3)2, =O, -OH, -SCH3, -S(=O)CH3, -S(=O)2CH3, unsubstituted -C(=O)-morpholinyl, -NH-C(=O)-CH3, )2 and NH-S(=O)2-CH3; wherein said -heterocyclobutyl , -heterocyclopentyl, or ocyclohexyl is optionally connected through -CH2- or -CH2CH2-; -oxazolyl, -isoxazolyl, olyl, -pyridinyl, -pyridazinyl, -pyrazinyl, -thiazolyl, -thiadiazolyl, - imidazolyl, -pyrimidinyl, or 5,6,7,8-tetrahydro-[1,2,4]triazolo[1,5-a]pyrazine, in each case unsubstituted or substituted with one, two, three or four substituents independently of one r selected from the group consisting of -F, -Cl, Br, -I, -CN, -OH, -CH3, -O-CH3, -C(=O)OH, -C(=O)OCH3, NH2, - C(=O)NHCH3, -C(=O)N(CH3)2, S(=O)CH3, -S(=O)2CH3 and -S-CH3, wherein said -oxazolyl, -isoxazolyl, -pyrazolyl, -pyridinyl, azinyl, -pyrazinyl, -thiazolyl, -thiadiazolyl, -imidazolyl, -pyrimidinyl, or 5,6,7,8-tetrahydro-[1,2,4]triazolo[1,5-a]pyrazine is optionally connected through -CH2-; or -phenyl, unsubstituted or substituted with one, two, three or four substituents independently of one another selected from the group consisting of -F, -Cl, Br, -I, -CN, -OH, -CH3, -O-CH3, -C(=O)OH, -C(=O)OCH3, - C(=O)NH2, NHCH3, N(CH3)2, S(=O)CH3, -S(=O)2 CH3 and -S-CH3, wherein said -phenyl is optionally connected through -CH2-; in case X means NR6, R6 means -H or -CH3; or in case X means NR6, R5 and R6 together with the nitrogen atom to which they are attached form a - pyrrolidinyl, -piperidinyl, -piperazinyl, -morpholinyl, -thiomorpholinyl, -thiomorpholinyl dioxide or - (methylsulfonyl)piperazinyl, in each case unsubstituted or substituted with one, two, three or four substituents independently of one r selected from the group consisting of =O, -OH, -CH2-OH, - C(=O)NH2, and -S(=O)2CH3, wherein said -pyrrolidinyl, -piperidinyl, -piperazinyl, -morpholinyl, - thiomorpholinyl,- thiomorpholinyl dioxide or -(methylsulfonyl)piperazinyl is optionally condensed with an imidazole moiety, unsubstituted; and R9, R10, R11, R12, R13, R14, R15, R16, R17, R18, R19, and R20 mean -H.
12. The compound according to any one of the preceding claims, which has (i) a structure according to general formula (I') R 13 16 10 9 R 14 R R R 15 R 11 R R 12 R 1 5 N R N R 2 O R 3 R 4 R 18 R 19 R 17 R 20 wherein R1 to R5, R9 to R20, and X are d as in any one of the preceding claims, or a physiologically able salt f; or. which has (ii) a ure according to general formula (IX) R 10 R 9 R 5 N O R (IX) (CH 2) 1 - 2 wherein RC means -H or -OH; R3 means -phenyl or fluorophenyl; R5 means -H, -CH3, -CH2CH2OH, or -CH2C(=O)NH2; R6 means -H or -CH3; or R5 and R6 together with the nitrogen atom to which they are attached form a ring and mean -(CH2)5-, wherein said ring is unsubstituted or substituted with one or two substituents independently of one another selected from the group consisting of -CH3, -OH, -S(=O)2CH3 and -C(=O)NH2; R9 and R10 independently of one another mean -H or -CH3; or a physiologically acceptable salt thereof.
13. The compound according to any one of the preceding claims, which is selected from the group consisting [1-(Cyclobutyl-methyl)dimethylaminooxophenyl-1,3-diazaspiro[4.5]decanyl]-N-[2-[2- [2-[2-[2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxy]-ethoxy]-ethoxy]-ethoxy]-ethyl]-acetamide; cis[[2-[1-(Cyclobutyl-methyl)dimethylaminooxophenyl-1,3-diazaspiro[4.5]decanyl]- acetyl]amino]-pyridinecarboxylic acid methyl ester; cis[1-(Cyclobutyl-methyl)dimethylaminooxophenyl-1,3-diazaspiro[4.5]decanyl]-N-[(1R)- 2-hydroxymethyl-ethyl]-acetamide; cis[1-(Cyclobutyl-methyl)dimethylaminooxophenyl-1,3-diazaspiro[4.5]decanyl]-N-[(1S)- 2-hydroxymethyl-ethyl]-acetamide; cis[1-(Cyclobutyl-methyl)dimethylaminooxophenyl-1,3-diazaspiro[4.5]decanyl]-N-methyl- N-(methylcarbamoyl-methyl)-acetamide; cis[[2-[1-(Cyclobutyl-methyl)dimethylaminooxophenyl-1,3-diazaspiro[4.5]decanyl]- acetyl]amino]-nicotinic acid methyl ester; cis[[2-[1-(Cyclobutyl-methyl)dimethylaminooxophenyl-1,3-diazaspiro[4.5]decanyl]- acetyl]-methyl-amino]methyl-propionamide; cis[[2-[1-(Cyclobutyl-methyl)dimethylaminooxophenyl-1,3-diazaspiro[4.5]decanyl]- acetyl]amino]-N,2-dimethyl-propionamide; cis[[2-[1-(Cyclobutyl-methyl)dimethylaminooxophenyl-1,3-diazaspiro[4.5]decanyl]- acetyl]-methyl-amino]-N,2-dimethyl-propionamide; cis[1-(Cyclobutyl-methyl)dimethylaminooxophenyl-1,3-diazaspiro[4.5]decanyl]-N- [(dimethyl-carbamoyl)-methyl]-N-methyl-acetamide; cis[[2-[1-(Cyclobutyl-methyl)dimethylaminooxophenyl-1,3-diazaspiro[4.5]decanyl]- acetyl]amino]methyl-propionamide; cis[1-(Cyclobutyl-methyl)dimethylaminooxophenyl-1,3-diazaspiro[4.5]decanyl]-N-(5- methoxy-pyridinyl)-acetamide; cis[1-(Cyclobutyl-methyl)dimethylaminooxophenyl-1,3-diazaspiro[4.5]decanyl]-N-(6- methoxy-pyridinyl)-acetamide; cis[1-(Cyclobutyl-methyl)dimethylaminooxophenyl-1,3-diazaspiro[4.5]decanyl]-N-(4- methoxy-pyridinyl)-acetamide; [[2-[1-(Cyclobutyl-methyl)dimethylaminooxophenyl-1,3-diazaspiro[4.5]decanyl]- acetyl]amino]-N-methyl-pyridinecarboxylic acid amide; cis[1-(Cyclobutyl-methyl)dimethylaminooxophenyl-1,3-diazaspiro[4.5]decanyl]-N-[(3- hydroxy-cyclobutyl)-methyl]-acetamide; cis[1-(Cyclobutyl-methyl)dimethylaminooxophenyl-1,3-diazaspiro[4.5]decanyl]-N-[(3- hydroxy-cyclobutyl)-methyl]-acetamide; cis[1-(Cyclobutyl-methyl)dimethylaminooxophenyl-1,3-diazaspiro[4.5]decanyl]-N-[(1- hydroxy-cyclopropyl)-methyl]-acetamide; cis[1-(Cyclobutyl-methyl)dimethylaminooxophenyl-1,3-diazaspiro[4.5]decanyl]-N-(3- morpholinyloxo-propyl)-acetamide; (1-Cyano-cyclopropyl)[1-(cyclobutyl-methyl)dimethylaminooxophenyl-1,3- diazaspiro[4.5]decanyl]-acetamide; cis[1-(Cyclobutyl-methyl)dimethylaminooxophenyl-1,3-diazaspiro[4.5]decanyl]-N-[(3- hydroxy-cyclopentyl)-methyl]-acetamide; cis[1-(Cyclobutyl-methyl)dimethylaminooxophenyl-1,3-diazaspiro[4.5]decanyl]-N-[[(2R)- 2-hydroxy-cyclohexyl]-methyl]-acetamide; cis[1-(Cyclobutyl-methyl)dimethylaminooxophenyl-1,3-diazaspiro[4.5]decanyl]-N-[2-[2- [2-(2-methoxy-ethoxy)-ethoxy]-ethoxy]-ethyl]-acetamide; cis[1-(Cyclobutyl-methyl)dimethylaminooxophenyl-1,3-diazaspiro[4.5]decanyl]-N-[(1- hydroxy-cyclohexyl)-methyl]-acetamide; [1-(Cyclobutyl-methyl)dimethylaminooxophenyl-1,3-diazaspiro[4.5]decanyl]-N-[2-[2- [2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxy]-ethoxy]-ethyl]-acetamide; cis-N-(6-Cyano-pyridinyl)[1-(cyclobutyl-methyl)dimethylaminooxophenyl-1,3- diazaspiro[4.5]decanyl]-acetamide; cis[[2-[1-(Cyclobutyl-methyl)dimethylaminooxophenyl-1,3-diazaspiro[4.5]decanyl]- acetyl]amino]-nicotinic acid methyl ester; cis[1-(Cyclobutyl-methyl)dimethylaminooxophenyl-1,3-diazaspiro[4.5]decanyl]-N-(3- methoxy-pyridinyl)-acetamide; cis[1-(Cyclobutyl-methyl)dimethylaminooxophenyl-1,3-diazaspiro[4.5]decanyl]-N-[2-[2- [2-[2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxy]-ethoxy]-ethoxy]-ethyl]-acetamide; cis-N-(4-Cyano-pyridinyl)[1-(cyclobutyl-methyl)dimethylaminooxophenyl-1,3- piro[4.5]decanyl]-acetamide; cis[1-(Cyclobutyl-methyl)dimethylaminooxophenyl-1,3-diazaspiro[4.5]decanyl]-N-(5- methoxy-pyrimidinyl)-acetamide; cis[[2-[1-(Cyclobutyl-methyl)dimethylaminooxophenyl-1,3-diazaspiro[4.5]decanyl]- acetyl]amino]-isonicotinic acid methyl ester; cis[1-(Cyclobutyl-methyl)dimethylaminooxophenyl-1,3-diazaspiro[4.5]decanyl]-N-(2- methoxy-pyridinyl)-acetamide; cis[1-(Cyclobutyl-methyl)dimethylaminooxophenyl-1,3-diazaspiro[4.5]decanyl]-N-(6- fluoro-pyridinyl)-acetamide; cis[1-(Cyclobutyl-methyl)dimethylaminooxophenyl-1,3-diazaspiro[4.5]decanyl]-N-(2- methyl-pyrimidinyl)-acetamide; cis[1-(Cyclobutyl-methyl)dimethylaminooxophenyl-1,3-diazaspiro[4.5]decanyl]-N-(5- methyl-pyrimidinyl)-acetamide; [1-(Cyclobutyl-methyl)dimethylaminooxophenyl-1,3-diazaspiro[4.5]decanyl]-N-(3- fluoro-pyridinyl)-acetamide; [1-(Cyclobutyl-methyl)dimethylaminooxophenyl-1,3-diazaspiro[4.5]decanyl]-N-(3- fluoro-pyridinyl)-acetamide; cis[1-(Cyclobutyl-methyl)dimethylaminooxophenyl-1,3-diazaspiro[4.5]decanyl]-N-(6- methoxy-pyridinyl)-acetamide; cis[1-(Cyclobutyl-methyl)dimethylaminooxophenyl-1,3-diazaspiro[4.5]decanyl]-N-(2- methyl-pyridinyl)-acetamide; cis[1-(Cyclobutyl-methyl)dimethylaminooxophenyl-1,3-diazaspiro[4.5]decanyl]-N-(4- methyl-pyridinyl)-acetamide; cis[1-(Cyclobutyl-methyl)dimethylaminooxophenyl-1,3-diazaspiro[4.5]decanyl]-N-(3- methyl-pyridinyl)-acetamide; cis[1-(Cyclobutyl-methyl)dimethylaminooxophenyl-1,3-diazaspiro[4.5]decanyl]-N-(6- methyl-pyridinyl)-acetamide; cis[1-(Cyclobutyl-methyl)dimethylaminooxophenyl-1,3-diazaspiro[4.5]decanyl]-N-(5- fluoro-pyridinyl)-acetamide; cis[1-(Cyclobutyl-methyl)dimethylaminooxophenyl-1,3-diazaspiro[4.5]decanyl]-N-(5- methyl-pyridinyl)-acetamide; cis[1-(Cyclobutyl-methyl)dimethylaminooxophenyl-1,3-diazaspiro[4.5]decanyl]-N-(4- methyl-pyridinyl)-acetamide; [1-(Cyclobutyl-methyl)dimethylaminooxophenyl-1,3-diazaspiro[4.5]decanyl]-N-(3- methyl-pyridinyl)-acetamide; cis[1-(Cyclobutyl-methyl)dimethylaminooxophenyl-1,3-diazaspiro[4.5]decanyl]-N-(3- methoxy-pyridinyl)-acetamide; cis[1-(Cyclobutyl-methyl)dimethylaminooxophenyl-1,3-diazaspiro[4.5]decanyl]-N-(6- methoxy-pyridazinyl)-acetamide; cis[1-(Cyclobutyl-methyl)dimethylaminooxophenyl-1,3-diazaspiro[4.5]decanyl]-N-(5- methylsulfonyl-pyridinyl)-acetamide; cis[1-(Cyclobutyl-methyl)dimethylaminooxophenyl-1,3-diazaspiro[4.5]decanyl]-N-(5- methoxy-pyridinyl)-acetamide; cis[1-(Cyclobutyl-methyl)dimethylaminooxophenyl-1,3-diazaspiro[4.5]decanyl]-N-(6- methylsulfonyl-pyridinyl)-acetamide; cis[1-(Cyclobutyl-methyl)dimethylaminooxophenyl-1,3-diazaspiro[4.5]decanyl]-N-(6- methoxy-pyrazinyl)-acetamide; [1-(Cyclobutyl-methyl)dimethylaminooxophenyl-1,3-diazaspiro[4.5]decanyl]-N-(4- methoxy-pyridinyl)-acetamide; cis[1-(Cyclobutyl-methyl)dimethylaminooxophenyl-1,3-diazaspiro[4.5]decanyl]-N-(4- methoxy-pyrimidinyl)-acetamide; [1-(Cyclobutyl-methyl)dimethylaminooxophenyl-1,3-diazaspiro[4.5]decanyl]-N- (oxazolyl-methyl)-acetamide; cis[1-(Cyclobutyl-methyl)dimethylaminooxophenyl-1,3-diazaspiro[4.5]decanyl]-N- (oxazolyl-methyl)-acetamide; (Cyclobutyl-methyl)[2-[(3S,4S)-3,4-dihydroxy-piperidinyl]oxo-ethyl]dimethylamino phenyl-1,3-diazaspiro[4.5]decanone; cis(Cyclobutyl-methyl)[2-[(3S,4S)-3,4-dihydroxy-pyrrolidinyl]oxo-ethyl]dimethylamino- 8-phenyl-1,3-diazaspiro[4.5]decanone; cis(Cyclobutyl-methyl)[2-[(3S,4R)-3,4-dihydroxy-pyrrolidinyl]oxo-ethyl]dimethylamino- 8-phenyl-1,3-diazaspiro[4.5]decanone; cis[1-(Cyclobutyl-methyl)dimethylaminooxophenyl-1,3-diazaspiro[4.5]decanyl]-N- cyclopropyl-acetamide; cis[1-(Cyclobutyl-methyl)dimethylaminooxophenyl-1,3-diazaspiro[4.5]decanyl]-N-(2- hydroxy-ethyl)-N-methyl-acetamide; cis(Cyclobutyl-methyl)dimethylamino[2-(3-hydroxy-piperidinyl)oxo-ethyl]phenyl-1,3- diazaspiro[4.5]decanone; cis[1-(Cyclobutyl-methyl)dimethylaminooxophenyl-1,3-diazaspiro[4.5]decanyl]-N-[(1- hydroxy-cyclobutyl)-methyl]-acetamide; cis[[2-[1-(Cyclobutyl-methyl)dimethylaminooxophenyl-1,3-diazaspiro[4.5]decanyl]- acetyl]amino]-N,N-dimethyl-acetamide; cis(Cyclobutyl-methyl)dimethylamino[2-oxo(5,6,7,8-tetrahydro-[1,2,4]triazolo[1,5-a]pyrazin- 7-yl)-ethyl]phenyl-1,3-diazaspiro[4.5]decanone; cis[[2-[1-(Cyclobutyl-methyl)dimethylaminooxophenyl-1,3-diazaspiro[4.5]decanyl]- acetyl]amino]-N,N-dimethyl-propionamide; cis[1-(Cyclobutyl-methyl)dimethylaminooxophenyl-1,3-diazaspiro[4.5]decanyl]-N-[2-[2- [2-[2-[2-[2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxy]-ethoxy]-ethoxy]-ethoxy]-ethoxy]-ethyl]-acetamide; cis[1-(Cyclobutyl-methyl)dimethylaminooxophenyl-1,3-diazaspiro[4.5]decanyl]-N-(4- y-pyrimidinyl)-acetamide; cis[1-(Cyclobutyl-methyl)dimethylaminooxophenyl-1,3-diazaspiro[4.5]decanyl]-N-(2- methoxy-pyrimidinyl)-acetamide; cis-N-(5-Cyano-pyridinyl)[1-(cyclobutyl-methyl)dimethylaminooxophenyl-1,3- diazaspiro[4.5]decanyl]-acetamide; cis[[2-[1-(Cyclobutyl-methyl)dimethylaminooxophenyl-1,3-diazaspiro[4.5]decanyl]- acetyl]amino]-N-methyl-pyridinecarboxylic acid amide; cis[1-(Cyclobutyl-methyl)dimethylaminooxophenyl-1,3-diazaspiro[4.5]decanyl]-N-(5- methoxy-pyrimidinyl)-acetamide; cis-N-(2-Cyano-pyrimidinyl)[1-(cyclobutyl-methyl)dimethylaminooxophenyl-1,3- piro[4.5]decanyl]-acetamide; cis[[2-[1-(Cyclobutyl-methyl)dimethylaminooxophenyl-1,3-diazaspiro[4.5]decanyl]- acetyl]amino]-pyridinecarboxylic acid amide; cis-N-(3-Cyano-pyridinyl)[1-(cyclobutyl-methyl)dimethylaminooxophenyl-1,3- diazaspiro[4.5]decanyl]-acetamide; cis[[2-[1-(Cyclobutyl-methyl)dimethylaminooxophenyl-1,3-diazaspiro[4.5]decanyl]- acetyl]amino]-acetamide; cis[[2-[1-(Cyclobutyl-methyl)dimethylaminooxophenyl-1,3-diazaspiro[4.5]decanyl]- acetyl]amino]-pyridinecarboxylic acid amide; cis-N-(4-Cyano-pyrimidinyl)[1-(cyclobutyl-methyl)dimethylaminooxophenyl-1,3- piro[4.5]decanyl]-acetamide; cis[1-(Cyclobutyl-methyl)dimethylaminooxophenyl-1,3-diazaspiro[4.5]decanyl]-N- ([1,3,4]thiadiazolyl)-acetamide; cis[1-(Cyclobutyl-methyl)dimethylaminooxophenyl-1,3-diazaspiro[4.5]decanyl]-N-thiazol- 2-yl-acetamide; cis[1-(Cyclobutyl-methyl)dimethylaminooxophenyl-1,3-diazaspiro[4.5]decanyl]-N-(5- methyl-isoxazolyl)-acetamide; cis[1-(Cyclobutyl-methyl)dimethylaminooxophenyl-1,3-diazaspiro[4.5]decanyl]-N- isoxazolyl-acetamide; cis[1-(Cyclobutyl-methyl)dimethylaminooxophenyl-1,3-diazaspiro[4.5]decanyl]-N-(1- methyl-1H-pyrazolyl)-acetamide; cis- N-(4-Cyanomethylsulfanyl-1H-pyrazolyl)[1-(cyclobutyl-methyl)dimethylaminooxo phenyl-1,3-diazaspiro[4.5]decanyl]-acetamide; cis[1-(Cyclobutyl-methyl)dimethylaminooxophenyl-1,3-diazaspiro[4.5]decanyl]-N-(5- methoxy-pyrazinyl)-acetamide; cis[1-(Cyclobutyl-methyl)dimethylaminooxophenyl-1,3-diazaspiro[4.5]decanyl]-N- (pyridazinyl-methyl)-acetamide; cis[1-(Cyclobutyl-methyl)dimethylaminooxophenyl-1,3-diazaspiro[4.5]decanyl]-N-[(2- hydroxyphenyl)-methyl]-acetamide; cis[1-(Cyclobutyl-methyl)dimethylaminooxophenyl-1,3-diazaspiro[4.5]decanyl]-N-[(1- methyl-1H-imidazolyl)-methyl]-acetamide; cis[1-(Cyclobutyl-methyl)dimethylaminooxophenyl-1,3-diazaspiro[4.5]decanyl]-N-[(4- methyl-pyridinyl)-methyl]-acetamide; [1-(Cyclobutyl-methyl)dimethylaminooxophenyl-1,3-diazaspiro[4.5]decanyl]-N- (pyrimidinyl-methyl)-acetamide; cis[1-(Cyclobutyl-methyl)dimethylaminooxophenyl-1,3-diazaspiro[4.5]decanyl]-N- (pyridazinyl-methyl)-acetamide; cis[1-(Cyclobutyl-methyl)dimethylaminooxophenyl-1,3-diazaspiro[4.5]decanyl]-N- (pyrimidinyl-methyl)-acetamide; cis[1-(Cyclobutyl-methyl)dimethylaminooxophenyl-1,3-diazaspiro[4.5]decanyl]-N- (pyrazinyl-methyl)-acetamide; cis[1-(Cyclobutyl-methyl)dimethylaminooxophenyl-1,3-diazaspiro[4.5]decanyl]-N- (oxazolyl-methyl)-acetamide; cis[1-(Cyclobutyl-methyl)dimethylaminooxophenyl-1,3-diazaspiro[4.5]decanyl]-N-[(2- methyl-pyridinyl)-methyl]-acetamide; cis[1-(Cyclobutyl-methyl)dimethylaminooxophenyl-1,3-diazaspiro[4.5]decanyl]-N-[(2- methoxy-pyridinyl)-methyl]-acetamide; cis[1-(Cyclobutyl-methyl)dimethylaminooxophenyl-1,3-diazaspiro[4.5]decanyl]-N-[(4- methoxy-pyridinyl)-methyl]-acetamide; [1-(Cyclobutyl-methyl)dimethylaminooxophenyl-1,3-diazaspiro[4.5]decanyl]-N-[(6- methyl-pyridinyl)-methyl]-acetamide; cis[1-(Cyclobutyl-methyl)dimethylaminooxophenyl-1,3-diazaspiro[4.5]decanyl]-N-[(6- y-pyridinyl)-methyl]-acetamide; cis[1-(Cyclobutyl-methyl)dimethylaminooxophenyl-1,3-diazaspiro[4.5]decanyl]-N-[(2- methoxyphenyl)-methyl]-acetamide; cis[1-(Cyclobutyl-methyl)dimethylaminooxophenyl-1,3-diazaspiro[4.5]decanyl]-N-(otolyl-methyl amide; cis[[2-[1-(Cyclobutyl-methyl)dimethylaminooxophenyl-1,3-diazaspiro[4.5]decanyl]- acetyl]amino]-N-methyl-pyridinecarboxylic acid amide; cis[[2-[1-(Cyclobutyl-methyl)dimethylaminooxophenyl-1,3-diazaspiro[4.5]decanyl]- acetyl]amino]-pyridinecarboxylic acid amide; cis[1-(Cyclobutyl-methyl)dimethylaminooxophenyl-1,3-diazaspiro[4.5]decanyl]-N-(6- methoxy-pyrimidinyl)-acetamide; [1-(Cyclobutyl-methyl)dimethylaminooxophenyl-1,3-diazaspiro[4.5]decanyl]-N-(2- methoxy-pyrimidinyl)-acetamide; cis[1-(Cyclobutyl-methyl)dimethylaminooxophenyl-1,3-diazaspiro[4.5]decanyl]-N-(4- hydroxy-pyrimidinyl)-acetamide; cis[1-(Cyclobutyl-methyl)dimethylaminooxophenyl-1,3-diazaspiro[4.5]decanyl]-N-(2- hydroxy-pyrimidinyl)-acetamide; cis[1-(Cyclobutyl-methyl)dimethylaminooxophenyl-1,3-diazaspiro[4.5]decanyl]-N-(5- hydroxy-pyridinyl)-acetamide; cis[1-(Cyclobutyl-methyl)dimethylaminooxophenyl-1,3-diazaspiro[4.5]decanyl]-N-(1,1- dioxo-thianyl)-acetamide; cis(Cyclobutyl-methyl)dimethylamino[2-(1,1-dioxo-[1,4]thiazinanyl)oxo-ethyl]phenyl- 1,3-diazaspiro[4.5]decanone; [8-Dimethylamino(2-methoxy-ethyl)oxophenyl-1,3-diazaspiro[4.5]decanyl]-N- pyrimidinyl-acetamide; cis[8-Dimethylamino(2-methoxy-ethyl)oxophenyl-1,3-diazaspiro[4.5]decanyl]-N-methylacetamide cis-N-(5-Cyano-pyrimidinyl)[1-(cyclobutyl-methyl)dimethylaminooxophenyl-1,3- diazaspiro[4.5]decanyl]-acetamide; cis[1-(Cyclobutyl-methyl)dimethylaminooxophenyl-1,3-diazaspiro[4.5]decanyl]-N-(5- methylsulfanyl-pyridinyl)-acetamide; cis[1-(Cyclobutyl-methyl)dimethylaminooxophenyl-1,3-diazaspiro[4.5]decanyl]-N-(4- methoxy-pyrimidinyl)-acetamide; cis[1-(Cyclobutyl-methyl)dimethylaminooxophenyl-1,3-diazaspiro[4.5]decanyl]-N-(6- methylsulfanyl-pyridinyl)-acetamide; cis[8-Dimethylamino(2-methoxy-ethyl)oxophenyl-1,3-diazaspiro[4.5]decanyl]-N-(2- hydroxy-ethyl)-acetamide; cis[[2-[8-Dimethylamino(2-methoxy-ethyl)oxophenyl-1,3-diazaspiro[4.5]decanyl]- acetyl]amino]-acetamide; cis[1-(Cyclobutyl-methyl)dimethylaminooxophenyl-1,3-diazaspiro[4.5]decanyl]-N-methylacetamide cis[1-(Cyclobutyl-methyl)dimethylaminooxophenyl-1,3-diazaspiro[4.5]decanyl]-N-(2- hydroxy-ethyl)-acetamide; [1-(Cyclobutyl-methyl)dimethylaminooxophenyl-1,3-diazaspiro[4.5]decanyl]-N-(6- hydroxy-pyridinyl)-acetamide; cis[1-(Cyclobutyl-methyl)dimethylaminooxophenyl-1,3-diazaspiro[4.5]decanyl]-N-[(2- methoxy-pyrimidinyl)-methyl]-acetamide; cis[1-(Cyclobutyl-methyl)dimethylaminooxophenyl-1,3-diazaspiro[4.5]decanyl]-N-[(4- methoxy-pyrimidinyl)-methyl]-acetamide; cis-N-(2-Cyano-pyrimidinyl)[1-(cyclobutyl-methyl)dimethylaminooxophenyl-1,3- diazaspiro[4.5]decanyl]-acetamide; [1-(Cyclobutyl-methyl)dimethylaminooxophenyl-1,3-diazaspiro[4.5]decanyl]-N-[6- (methylsulfinyl)-pyridinyl]-acetamide; cis[[2-[1-(Cyclobutyl-methyl)methylaminooxophenyl-1,3-diazaspiro[4.5]decanyl]- acetyl]amino]methyl-propionamide; cis[[2-[1-(Cyclobutyl-methyl)methylaminooxophenyl-1,3-diazaspiro[4.5]decanyl]- acetyl]amino]-N-methyl-acetamide; [[2-[1-(Cyclobutyl-methyl)methylaminooxophenyl-1,3-diazaspiro[4.5]decanyl]- acetyl]amino]-acetamide; cis[1-(Cyclobutyl-methyl)dimethylaminooxophenyl-1,3-diazaspiro[4.5]decanyl]-N-[2-[2- (2-methoxy-ethoxy)-ethoxy]-ethyl]-acetamide; cis-N-(Carbamoyl-methyl)[1-(cyclobutyl-methyl)methylaminooxophenyl-1,3- diazaspiro[4.5]decanyl]-N-methyl-acetamide; cis[1-(Cyclobutyl-methyl)methylaminooxophenyl-1,3-diazaspiro[4.5]decanyl]-N-methyl- N-(methylcarbamoyl-methyl)-acetamide; cis[8-Dimethylamino[(1-hydroxy-cyclobutyl)-methyl]oxophenyl-1,3-diazaspiro[4.5]decan yl]-N-(2-methylsulfonyl-ethyl)-acetamide; cis[8-Dimethylamino[(1-hydroxy-cyclobutyl)-methyl]oxophenyl-1,3-diazaspiro[4.5]decan yl]-N-pyrimidinyl-acetamide; cis[1-(Cyclobutyl-methyl)dimethylaminooxophenyl-1,3-diazaspiro[4.5]decanyl]-N-(6- methylsulfonyl-pyridinyl)-acetamide; cis[8-Dimethylamino[(dimethyl-carbamoyl)-methyl]oxophenyl-1,3-diazaspiro[4.5]decan yl]-N-(2-hydroxy-ethyl)-acetamide; cis[[2-[1-(Cyclobutyl-methyl)methylaminooxophenyl-1,3-diazaspiro[4.5]decanyl]-acetyl]- methyl-amino]methyl-propionamide; cis(Cyclobutyl-methyl)[2-(1,1-dioxo-[1,4]thiazinanyl)oxo-ethyl]methylaminophenyl- azaspiro[4.5]decanone; cis[1-(Cyclobutyl-methyl)methylaminooxophenyl-1,3-diazaspiro[4.5]decanyl]-N-[2-[2-[2- [2-[2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxy]-ethoxy]-ethoxy]-ethoxy]-ethyl]-acetamide; cis[[2-[1-(Cyclobutyl-methyl)methylaminooxophenyl-1,3-diazaspiro[4.5]decanyl]- acetyl]amino]-N,N-dimethyl-acetamide; cis[1-(Cyclobutyl-methyl)dimethylaminooxophenyl-1,3-diazaspiro[4.5]decanyl]-N-(5- hydroxy-pyrimidinyl)-acetamide; cis[1-(Cyclobutyl-methyl)dimethylaminooxophenyl-1,3-diazaspiro[4.5]decanyl]-N-(4- methylsulfonyl-pyridinyl)-acetamide; cis[[2-[1-(Cyclobutyl-methyl)dimethylaminooxophenyl-1,3-diazaspiro[4.5]decanyl]- acetyl]amino]-N-methyl-acetamide; cis-N-(Carbamoyl-methyl)[1-(cyclobutyl-methyl)dimethylaminooxophenyl-1,3- diazaspiro[4.5]decanyl]-N-methyl-acetamide; cis(8-Dimethylaminooxophenylpropyl-1,3-diazaspiro[4.5]decanyl)-N-methyl-acetamide; cis[8-Dimethylamino(3-methoxy-propyl)oxophenyl-1,3-diazaspiro[4.5]decanyl]-N-methylacetamide cis[1-(Cyclobutyl-methyl)dimethylaminooxophenyl-1,3-diazaspiro[4.5]decanyl]-N-[4- (methylsulfinyl)-pyridinyl]-acetamide; cis[1-(Cyclobutyl-methyl)dimethylaminooxophenyl-1,3-diazaspiro[4.5]decanyl]-N-(3- hydroxy-pyridinyl)-acetamide; cis[1-(Cyclobutyl-methyl)dimethylaminooxophenyl-1,3-diazaspiro[4.5]decanyl]-N-(2- sulfonyl-ethyl)-acetamide; cis(Cyclobutyl-methyl)[2-[(3S,4R)-3,4-dihydroxy-pyrrolidinyl]oxo-ethyl]dimethylamino- 8-phenyl-1,3-diazaspiro[4.5]decanone; cis[1-(Cyclobutyl-methyl)methylaminooxophenyl-1,3-diazaspiro[4.5]decanyl]-N-(2- hydroxy-ethyl)-acetamide; cis[8-Dimethylamino[(dimethyl-carbamoyl)-methyl]oxophenyl-1,3-diazaspiro[4.5]decan pyrimidinyl-acetamide; cis[8-Dimethylamino[(dimethyl-carbamoyl)-methyl]oxophenyl-1,3-diazaspiro[4.5]decan yl]-N-methyl-acetamide; cis[[2-[8-Dimethylamino(2-methyl-propyl)oxophenyl-1,3-diazaspiro[4.5]decanyl]- acetyl]amino]-acetamide; cis[8-Dimethylamino[(1-hydroxy-cyclobutyl)-methyl]oxophenyl-1,3-diazaspiro[4.5]decan yl]-acetamide; cis[8-Dimethylamino[(1-hydroxy-cyclobutyl)-methyl]oxophenyl-1,3-diazaspiro[4.5]decan methyl-acetamide; [[2-[8-Dimethylamino(3-methoxy-propyl)oxophenyl-1,3-diazaspiro[4.5]decanyl]- ]amino]-acetamide; cis[8-Dimethylamino(2-methyl-propyl)oxophenyl-1,3-diazaspiro[4.5]decanyl]-N-methylacetamide cis(Cyclobutyl-methyl)[2-[(3S,4R)-3,4-dihydroxy-pyrrolidinyl]oxo-ethyl]methylamino phenyl-1,3-diazaspiro[4.5]decanone; cis[8-Dimethylamino[(1-methyl-cyclobutyl)-methyl]oxophenyl-1,3-diazaspiro[4.5]decan yl]-N-methyl-acetamide; cis[8-Dimethylamino[(1-methyl-cyclobutyl)-methyl]oxophenyl-1,3-diazaspiro[4.5]decan yl]-N-pyrimidinyl-acetamide; cis[[2-[8-Dimethylamino[(1-methyl-cyclobutyl)-methyl]oxophenyl-1,3-diazaspiro[4.5]decan- 3-yl]-acetyl]amino]-acetamide; cis[8-Dimethylamino[(1-methyl-cyclobutyl)-methyl]oxophenyl-1,3-diazaspiro[4.5]decan yl]-N-(2-hydroxy-ethyl)-acetamide; cis[[2-[1-(Cyclopropyl-methyl)dimethylaminooxophenyl-1,3-diazaspiro[4.5]decanyl]- acetyl]amino]-acetamide; cis[1-(Cyclobutyl-methyl)(ethyl-methyl-amino)oxophenyl-1,3-diazaspiro[4.5]decanyl]-N- methyl-acetamide; cis[[2-(8-Dimethylaminooxophenylpropyl-1,3-diazaspiro[4.5]decanyl)-acetyl]amino]- acetamide; cis[[2-[8-Dimethylamino[(1-hydroxy-cyclobutyl)-methyl]oxophenyl-1,3- diazaspiro[4.5]decanyl]-acetyl]amino]-acetamide; cis[8-Dimethylamino[(1-hydroxy-cyclobutyl)-methyl]oxophenyl-1,3-diazaspiro[4.5]decan yl]-N-(2-hydroxy-ethyl)-acetamide; cis[8-Dimethylamino[(1-hydroxy-cyclobutyl)-methyl]oxophenyl-1,3-diazaspiro[4.5]decan yl]-N-(1,1-dioxo-thianyl)-acetamide; cis[1-(Cyclopropyl-methyl)dimethylaminooxophenyl-1,3-diazaspiro[4.5]decanyl]-N- methyl-acetamide; cis[1-[(1-Cyano-cyclobutyl)-methyl]dimethylaminooxophenyl-1,3-diazaspiro[4.5]decan yl]-N-methyl-acetamide; cis[1-(Cyclobutyl-methyl)(ethyl-methyl-amino)oxophenyl-1,3-diazaspiro[4.5]decanyl]-N- (2-hydroxy-ethyl)-acetamide; cis[[2-[1-(Cyclobutyl-methyl)(ethyl-methyl-amino)oxophenyl-1,3-diazaspiro[4.5]decanyl]- acetyl]amino]-acetamide; cis[[2-[1-(Cyclobutyl-methyl)methylaminooxophenyl-1,3-diazaspiro[4.5]decanyl]- acetyl]amino]-N,2-dimethyl-propionamide; cis[8-Dimethylamino(3-methoxy-propyl)oxophenyl-1,3-diazaspiro[4.5]decanyl]-N-(2- hydroxy-ethyl)-acetamide; [8-Dimethylamino(3-methoxy-propyl)oxophenyl-1,3-diazaspiro[4.5]decanyl]-N-methyl- N-(methylcarbamoyl-methyl)-acetamide; cisDimethylamino(3-methoxy-propyl)[2-oxo(3-oxo-piperazinyl)-ethyl]phenyl-1,3- diazaspiro[4.5]decanone; cis-N-(Carbamoyl-methyl)[8-dimethylamino(3-methoxy-propyl)oxophenyl-1,3- piro[4.5]decanyl]-N-methyl-acetamide; cis[8-Dimethylamino(3-methoxy-propyl)oxophenyl-1,3-diazaspiro[4.5]decanyl]-N-[(3- hydroxy-cyclobutyl)-methyl]-acetamide; cis[8-Dimethylamino(3-methoxy-propyl)oxophenyl-1,3-diazaspiro[4.5]decanyl]-N-[(3- y-cyclobutyl)-methyl]-acetamide; cis[8-Dimethylamino(3-methoxy-propyl)oxophenyl-1,3-diazaspiro[4.5]decanyl]-N-[(3- hydroxy-cyclopentyl)-methyl]-acetamide; cis[8-Dimethylamino(3-methoxy-propyl)oxophenyl-1,3-diazaspiro[4.5]decanyl]-N- pyridazinyl-acetamide; cis[8-Dimethylamino(3-methoxy-propyl)oxophenyl-1,3-diazaspiro[4.5]decanyl]-N-(6- methoxy-pyridinyl)-acetamide; cis-N-(2-Cyanoethyl)[8-dimethylamino(3-methoxy-propyl)oxophenyl-1,3- diazaspiro[4.5]decanyl]-acetamide; cis[8-Dimethylamino(3-methoxy-propyl)oxophenyl-1,3-diazaspiro[4.5]decanyl]-N- pyrimidinyl-acetamide; cis[8-Dimethylamino(3-methoxy-propyl)oxophenyl-1,3-diazaspiro[4.5]decanyl]-N- pyrimidinyl-acetamide; cis[1-(Cyclobutyl-methyl)(ethyl-methyl-amino)oxophenyl-1,3-diazaspiro[4.5]decanyl]-N- (6-methoxy-pyridinyl)-acetamide; cis[8-Dimethylamino[(1-hydroxy-cyclobutyl)-methyl]oxophenyl-1,3-diazaspiro[4.5]decan yl]-N-pyridinyl-acetamide; cis[1-(Cyclobutyl-methyl)dimethylaminooxophenyl-1,3-diazaspiro[4.5]decanyl]- acetamide; [1-(Cyclobutyl-methyl)dimethylaminooxophenyl-1,3-diazaspiro[4.5]decanyl]-N- pyrimidinyl-acetamide; cis[1-(Cyclobutyl-methyl)dimethylaminooxophenyl-1,3-diazaspiro[4.5]decanyl]-N-(2- methoxy-ethyl)-acetamide; cis[1-(Cyclobutyl-methyl)dimethylaminooxophenyl-1,3-diazaspiro[4.5]decanyl]-N-(2- hydroxy-ethyl)-acetamide; cis[1-(Cyclobutyl-methyl)dimethylaminooxophenyl-1,3-diazaspiro[4.5]decanyl]-N-[2-[2- [2-[2-[2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxy]-ethoxy]-ethoxy]-ethoxy]-ethyl]-acetamide; cis[1-(Cyclobutyl-methyl)methylaminooxophenyl-1,3-diazaspiro[4.5]decanyl]-N-methylacetamide cis-(2S)[2-[1-(Cyclobutyl-methyl)dimethylaminooxophenyl-1,3-diazaspiro[4.5]decanyl]- acetyl]-pyrrolidinecarboxylic acid amide; cis[[2-[1-(Cyclobutyl-methyl)dimethylaminooxophenyl-1,3-diazaspiro[4.5]decanyl]- acetyl]amino]-N,N-dimethyl-acetamide; cis[1-(Cyclobutyl-methyl)dimethylaminooxophenyl-1,3-diazaspiro[4.5]decanyl]-N- (oxetanyl)-acetamide; cis[[2-[1-(Cyclobutyl-methyl)dimethylaminooxophenyl-1,3-diazaspiro[4.5]decanyl]- acetyl]amino]-acetamide; cis(Cyclobutyl-methyl)dimethylamino[2-oxo(3-oxo-piperazinyl)-ethyl]phenyl-1,3- diazaspiro[4.5]decanone; cis[1-(Cyclobutyl-methyl)dimethylaminooxophenyl-1,3-diazaspiro[4.5]decanyl]-N-(1,1- dioxo-thianyl)-acetamide; cis(Cyclobutyl-methyl)dimethylamino[2-[2-(hydroxymethyl)-morpholinyl]oxo-ethyl] -1,3-diazaspiro[4.5]decanone; cis-N-(Carbamoyl-methyl)[1-(cyclobutyl-methyl)dimethylaminooxophenyl-1,3- piro[4.5]decanyl]-N-methyl-acetamide; cis-N-(Cyano-methyl)[1-(cyclobutyl-methyl)dimethylaminooxophenyl-1,3- diazaspiro[4.5]decanyl]-acetamide; cis-N-(2-Acetylamino-ethyl)[1-(cyclobutyl-methyl)dimethylaminooxophenyl-1,3- diazaspiro[4.5]decanyl]-acetamide; cis[1-(Cyclobutyl-methyl)dimethylaminooxophenyl-1,3-diazaspiro[4.5]decanyl]-N-(2- methylsulfonyl-ethyl)-acetamide; cis(Cyclobutyl-methyl)dimethylamino[2-(1,1-dioxo-[1,4]thiazinanyl)oxo-ethyl]phenyl- 1,3-diazaspiro[4.5]decanone; cis[1-(Cyclobutyl-methyl)dimethylaminooxophenyl-1,3-diazaspiro[4.5]decanyl]-N-[(1,1- dioxo-thianyl)-methyl]-acetamide; cis(Cyclobutyl-methyl)dimethylamino[2-(4-methylsulfonyl-piperazinyl)oxo-ethyl] phenyl-1,3-diazaspiro[4.5]decanone; cis-N-(2-Cyanoethyl)[1-(cyclobutyl-methyl)dimethylaminooxophenyl-1,3- diazaspiro[4.5]decanyl]-acetamide; cis[1-(Cyclobutyl-methyl)dimethylaminooxophenyl-1,3-diazaspiro[4.5]decanyl]-N-(2- hydroxymethyl-propyl)-acetamide; cis[1-(Cyclobutyl-methyl)dimethylaminooxophenyl-1,3-diazaspiro[4.5]decanyl]-N-(2- morpholinyloxo-ethyl)-acetamide; cis[1-(Cyclobutyl-methyl)dimethylaminooxophenyl-1,3-diazaspiro[4.5]decanyl]-N-[2-(2- hydroxy-ethoxy)-ethyl]-acetamide; cis[[2-[1-(Cyclobutyl-methyl)dimethylaminooxophenyl-1,3-diazaspiro[4.5]decanyl]- acetyl]amino]-N-methyl-acetamide; cis[1-(Cyclobutyl-methyl)dimethylaminooxophenyl-1,3-diazaspiro[4.5]decanyl]-N-[2- (methanesulfonamido)-ethyl]-acetamide; cis[1-(Cyclobutyl-methyl)dimethylaminooxophenyl-1,3-diazaspiro[4.5]decanyl]-N-[(1- hydroxy-cyclopentyl)-methyl]-acetamide; [1-(Cyclobutyl-methyl)dimethylaminooxophenyl-1,3-diazaspiro[4.5]decanyl]-N-[(4- hydroxy-cyclohexyl)-methyl]-acetamide; cis[1-(Cyclobutyl-methyl)dimethylaminooxophenyl-1,3-diazaspiro[4.5]decanyl]-N-[2-(2- y-ethoxy)-ethyl]-acetamide; cis[1-(Cyclobutyl-methyl)dimethylaminooxophenyl-1,3-diazaspiro[4.5]decanyl]-N-[2- (dimethylamino)ethyl]-acetamide; [1-(Cyclobutyl-methyl)[methyl-(2-methyl-propyl)-amino]oxophenyl-1,3- diazaspiro[4.5]decanyl]-N-methyl-acetamide; cis[1-(Cyclobutyl-methyl)dimethylaminooxophenyl-1,3-diazaspiro[4.5]decanyl]-N-methylacetamide cis[1-(Cyclobutyl-methyl)dimethylaminooxophenyl-1,3-diazaspiro[4.5]decanyl]-N- pyrimidinyl-acetamide; cis[1-(Cyclobutyl-methyl)dimethylaminooxophenyl-1,3-diazaspiro[4.5]decanyl]-N-(6- -pyridinyl)-acetamide; cis[1-(Cyclobutyl-methyl)dimethylaminooxophenyl-1,3-diazaspiro[4.5]decanyl]-N- pyridazinyl-acetamide; cis[1-(Cyclobutyl-methyl)dimethylaminooxophenyl-1,3-diazaspiro[4.5]decanyl]-N- pyrimidinyl-acetamide; cis[1-(Cyclobutyl-methyl)dimethylaminooxophenyl-1,3-diazaspiro[4.5]decanyl]-N- pyridazinyl-acetamide; cis[1-(Cyclobutyl-methyl)dimethylaminooxophenyl-1,3-diazaspiro[4.5]decanyl]-N-(6- methoxy-pyrimidinyl)-acetamide; cis[1-(Cyclobutyl-methyl)dimethylaminooxophenyl-1,3-diazaspiro[4.5]decanyl]-N-(2- methyl-pyridinyl)-acetamide; cis[8-Dimethylamino[(1-hydroxy-cyclobutyl)-methyl]oxophenyl-1,3-diazaspiro[4.5]decan yl]-N-pyridinyl-acetamide; cis[8-Dimethylamino[(1-hydroxy-cyclobutyl)-methyl]oxophenyl-1,3-diazaspiro[4.5]decan yl]-N-(oxetanyl)-acetamide; cis[8-Dimethylamino[(1-hydroxy-cyclobutyl)-methyl]oxophenyl-1,3-diazaspiro[4.5]decan yl]-N-(2-methoxy-ethyl)-acetamide; cis[1-[(1-Hydroxy-cyclobutyl)-methyl]methylaminooxophenyl-1,3-diazaspiro[4.5]decan yl]-N-(oxetanyl)-acetamide; cis[1-[(1-Hydroxy-cyclobutyl)-methyl]methylaminooxophenyl-1,3-diazaspiro[4.5]decan (2-methoxy-ethyl)-acetamide; cis[8-Dimethylamino(3-methoxy-propyl)oxophenyl-1,3-diazaspiro[4.5]decanyl]-N-(4- methoxy-pyridinyl)-acetamide; cis[8-Dimethylamino(3-methoxy-propyl)oxophenyl-1,3-diazaspiro[4.5]decanyl]-N- (pyrimidinyl-methyl)-acetamide; cisDimethylamino[2-(1,1-dioxo-[1,4]thiazinanyl)oxo-ethyl]phenylpropyl-1,3- diazaspiro[4.5]decanone; cis[8-Dimethylamino[(1-hydroxy-cyclobutyl)-methyl]oxophenyl-1,3-diazaspiro[4.5]decan yl]-N-pyridinyl-acetamide; cis[1-[(1-Cyano-cyclobutyl)-methyl]dimethylaminooxophenyl-1,3-diazaspiro[4.5]decan yl]-acetamide; cis[[2-[1-[(1-Cyano-cyclobutyl)-methyl]dimethylaminooxophenyl-1,3-diazaspiro[4.5]decan- 3-yl]-acetyl]amino]-acetamide; cis[1-[(1-Hydroxy-cyclobutyl)-methyl]methylaminooxophenyl-1,3-diazaspiro[4.5]decan yl]-N-methyl-acetamide; cis[2-(1,1-Dioxo-[1,4]thiazinanyl)oxo-ethyl]methylaminophenylpropyl-1,3- diazaspiro[4.5]decanone; cis[1-(Cyclobutyl-methyl)dimethylaminooxophenyl-1,3-diazaspiro[4.5]decanyl]-N- pyridinyl-acetamide; cisDimethylamino[(1-hydroxy-cyclobutyl)-methyl](2-morpholinyloxo-ethyl)phenyl-1,3- diazaspiro[4.5]decanone; cis[1-[(1-Hydroxy-cyclobutyl)-methyl]methylaminooxophenyl-1,3-diazaspiro[4.5]decan yl]-acetamide; cis(Cyclobutyl-methyl)dimethylamino(2-morpholinyloxo-ethyl)phenyl-1,3- diazaspiro[4.5]decanone; cis[1-(Cyclobutyl-methyl)dimethylaminooxophenyl-1,3-diazaspiro[4.5]decanyl]-N-(4- methylsulfanyl-pyridinyl)-acetamide; cis[2-(1,1-Dioxo-[1,4]thiazinanyl)oxo-ethyl]methylaminophenyl-1,3-diazaspiro[4.5]decan- 2-one; (8-Methylaminooxophenyl-1,3-diazaspiro[4.5]decanyl)-acetamide; cis(8-Dimethylaminooxophenyl-1,3-diazaspiro[4.5]decanyl)-acetamide; [2-(1,1-Dioxo-[1,4]thiazinanyl)oxo-ethyl]ethylaminophenyl-1,3-diazaspiro[4.5]decan trans[2-(1,1-Dioxo-[1,4]thiazinanyl)oxo-ethyl]ethylaminophenyl-1,3-diazaspiro[4.5]decan- 2-one; cis[1-(Cyclobutyl-methyl)methylaminooxophenyl-1,3-diazaspiro[4.5]decanyl]-N-methylacetamide cis(8-Ethylaminooxophenyl-1,3-diazaspiro[4.5]decanyl)-acetamide; trans(8-Ethylaminooxophenyl-1,3-diazaspiro[4.5]decanyl)-acetamide; cis(8-Dimethylaminooxophenyl-1,3-diazaspiro[4.5]decanyl)-N-(2-hydroxy-ethyl)-N-methylacetamide cisDimethylamino[2-(1,1-dioxo-[1,4]thiazinanyl)oxo-ethyl][(1-hydroxy-cyclobutyl)- methyl]phenyl-1,3-diazaspiro[4.5]decane-2,4-dione; cis(8-Dimethylaminooxophenyl-1,3-diazaspiro[4.5]decanyl)-N-phenyl-acetamide; cis-N-(Carbamoyl-methyl)[1-(cyclopropyl-methyl)dimethylaminooxophenyl-1,3- diazaspiro[4.5]decanyl]-N-methyl-acetamide; cis(8-Dimethylamino-2,4-dioxophenyl-1,3-diazaspiro[4.5]decanyl)-N-phenyl-acetamide; cis[1-(Cyclobutyl-methyl)dimethylaminooxophenyl-1,3-diazaspiro[4.5]decanyl]- acetamide; cis[8-Dimethylamino[(1-hydroxy-cyclobutyl)-methyl]oxophenyl-1,3-diazaspiro[4.5]decan yl]-N-[2-[2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxy]-ethyl]-acetamide; cis[2-(1,1-Dioxo-[1,4]thiazinanyl)oxo-ethyl][(1-hydroxy-cyclobutyl)-methyl]methylamino- 8-phenyl-1,3-diazaspiro[4.5]decane-2,4-dione; cis(8-Dimethylaminooxophenyl-1,3-diazaspiro[4.5]decanyl)-N-[2-[2-[2-(2-methoxy-ethoxy)- ethoxy]-ethoxy]-ethyl]-acetamide; cis-N-(Carbamoyl-methyl)-N-methyl(8-methylaminooxophenyl-1,3-diazaspiro[4.5]decanyl)- acetamide; (Carbamoyl-methyl)(8-dimethylaminooxophenyl-1,3-diazaspiro[4.5]decanyl)-N- methyl-acetamide; cis-N-(Carbamoyl-methyl)[8-dimethylamino(oxetanyl-methyl)oxophenyl-1,3- diazaspiro[4.5]decanyl]-N-methyl-acetamide; cis-N-(2-Hydroxy-ethyl)-N-methyl(8-methylaminooxophenyl-1,3-diazaspiro[4.5]decanyl)- acetamide; cis[1-(Cyclopropyl-methyl)dimethylaminooxophenyl-1,3-diazaspiro[4.5]decanyl]- acetamide; [1-(Cyclopropyl-methyl)dimethylaminooxophenyl-1,3-diazaspiro[4.5]decanyl]-N-(2- hydroxy-ethyl)-acetamide; cis[1-(Cyclobutyl-methyl)dimethylamino(3-fluorophenyl)oxo-1,3-diazaspiro[4.5]decanyl]- N-(2-hydroxy-ethyl)-N-methyl-acetamide; [1-(Cyclobutyl-methyl)dimethylamino(3-fluorophenyl)oxo-1,3-diazaspiro[4.5]decanyl]- acetic acid tert-butyl ester; cis[1-(Cyclopropyl-methyl)dimethylaminooxophenyl-1,3-diazaspiro[4.5]decanyl]-N-(2- hydroxy-ethyl)-N-methyl-acetamide; cis[1-(Cyclopropyl-methyl)dimethylaminooxophenyl-1,3-diazaspiro[4.5]decanyl]-N-(2- methylsulfonyl-ethyl)-acetamide; cis-N-(Carbamoyl-methyl)[1-(cyclobutyl-methyl)dimethylamino(3-fluorophenyl)oxo-1,3- diazaspiro[4.5]decanyl]-N-methyl-acetamide; cis[2-[8-Dimethylamino[(1-hydroxy-cyclobutyl)-methyl]oxophenyl-1,3-diazaspiro[4.5]decan- 3-yl]-acetyl]-piperidinecarboxylic acid amide; cisDimethylamino[(1-hydroxy-cyclobutyl)-methyl][2-(4-methylsulfonyl-piperidinyl)oxoethyl ]phenyl-1,3-diazaspiro[4.5]decanone; cis[1-(Cyclobutyl-methyl)dimethylamino(3-fluorophenyl)oxo-1,3-diazaspiro[4.5]decanyl]- N-(2-hydroxy-ethyl)-acetamide; trans[1-(Cyclobutyl-methyl)dimethylaminooxophenyl-1,3-diazaspiro[4.5]decanyl]-N-(2- hydroxy-ethyl)-acetamide; trans-N-(Carbamoyl-methyl)[1-(cyclobutyl-methyl)dimethylaminooxophenyl-1,3- diazaspiro[4.5]decanyl]-N-methyl-acetamide; cisDimethylamino[(1-hydroxy-cyclobutyl)-methyl][2-(4-hydroxymethyl-piperidinyl) oxo-ethyl]phenyl-1,3-diazaspiro[4.5]decanone; cis[1-(Cyclobutyl-methyl)dimethylamino(4-fluorophenyl)oxo-1,3-diazaspiro[4.5]decanyl]- N-(2-hydroxy-ethyl)-acetamide; trans(Cyclopropyl-methyl)dimethylamino(2-morpholinyloxo-ethyl)phenyl-1,3- diazaspiro[4.5]decanone; transDimethylamino(2-morpholinyloxo-ethyl)phenyl-1,3-diazaspiro[4.5]decanone; cis[1-(Cyclobutyl-methyl)dimethylamino(4-fluorophenyl)oxo-1,3-diazaspiro[4.5]decanyl]- N-(2-hydroxy-ethyl)-N-methyl-acetamide; cis-N-(Carbamoyl-methyl)[1-(cyclobutyl-methyl)dimethylamino(4-fluorophenyl)oxo-1,3- diazaspiro[4.5]decanyl]-N-methyl-acetamide; cis(Cyclopropyl-methyl)dimethylamino[2-(4-hydroxymethyl-piperidinyl)oxo-ethyl] phenyl-1,3-diazaspiro[4.5]decanone; cis[2-[1-(Cyclopropyl-methyl)dimethylaminooxophenyl-1,3-diazaspiro[4.5]decanyl]- acetyl]-piperidinecarboxylic acid amide; trans[1-(Cyclopropyl-methyl)dimethylaminooxophenyl-1,3-diazaspiro[4.5]decanyl]- acetamide; trans[1-(Cyclopropyl-methyl)dimethylaminooxophenyl-1,3-diazaspiro[4.5]decanyl]-N- -acetamide; 1-(Cyclopropyl-methyl)dimethylamino[2-(1,1-dioxo-[1,4]thiazinanyl)oxo-ethyl] phenyl-1,3-diazaspiro[4.5]decanone; (Cyclopropyl-methyl)dimethylamino[2-(4-methylsulfonyl-piperidinyl)oxo-ethyl] phenyl-1,3-diazaspiro[4.5]decanone; cisDimethylamino[2-(1,1-dioxo-[1,4]thiazinanyl)oxo-ethyl][(1-hydroxy-cyclobutyl)- methyl]phenyl-1,3-diazaspiro[4.5]decanone; trans(8-Dimethylaminooxophenyl-1,3-diazaspiro[4.5]decanyl)-acetamide; transDimethylamino[2-(1,1-dioxo-[1,4]thiazinanyl)oxo-ethyl]phenyl-1,3- diazaspiro[4.5]decanone; cis(dimethylamino)phenyl(2,2,2-trifluoroethyl)(2-(trifluoromethyl)pyrimidinyl)-1,3- diazaspiro[4.5]decanone; cis(dimethylamino)phenyl(2-(trifluoromethyl)pyrimidinyl)(3,3,3-trifluoropropyl)-1,3- diazaspiro[4.5]decanone and the physiologically acceptable salts thereof.
14. Use of the compound according to any one of the preceding claims for the cture of a medicament for treating pain.
15. A medicament comprising a compound according to any one of claims 1 to 13.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16151014 | 2016-01-13 | ||
| PCT/EP2017/025007 WO2017121649A1 (en) | 2016-01-13 | 2017-01-13 | 3-(carboxymethyl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NZ745184A NZ745184A (en) | 2024-03-22 |
| NZ745184B2 true NZ745184B2 (en) | 2024-06-25 |
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