NZ749844B2 - Solid forms of ttk inhibitor - Google Patents
Solid forms of ttk inhibitor Download PDFInfo
- Publication number
- NZ749844B2 NZ749844B2 NZ749844A NZ74984417A NZ749844B2 NZ 749844 B2 NZ749844 B2 NZ 749844B2 NZ 749844 A NZ749844 A NZ 749844A NZ 74984417 A NZ74984417 A NZ 74984417A NZ 749844 B2 NZ749844 B2 NZ 749844B2
- Authority
- NZ
- New Zealand
- Prior art keywords
- crystal
- solid forms
- formula
- ttk inhibitor
- compound
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C30—CRYSTAL GROWTH
- C30B—SINGLE-CRYSTAL GROWTH; UNIDIRECTIONAL SOLIDIFICATION OF EUTECTIC MATERIAL OR UNIDIRECTIONAL DEMIXING OF EUTECTOID MATERIAL; REFINING BY ZONE-MELTING OF MATERIAL; PRODUCTION OF A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; SINGLE CRYSTALS OR HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; AFTER-TREATMENT OF SINGLE CRYSTALS OR A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; APPARATUS THEREFOR
- C30B29/00—Single crystals or homogeneous polycrystalline material with defined structure characterised by the material or by their shape
- C30B29/54—Organic compounds
- C30B29/58—Macromolecular compounds
-
- C—CHEMISTRY; METALLURGY
- C30—CRYSTAL GROWTH
- C30B—SINGLE-CRYSTAL GROWTH; UNIDIRECTIONAL SOLIDIFICATION OF EUTECTIC MATERIAL OR UNIDIRECTIONAL DEMIXING OF EUTECTOID MATERIAL; REFINING BY ZONE-MELTING OF MATERIAL; PRODUCTION OF A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; SINGLE CRYSTALS OR HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; AFTER-TREATMENT OF SINGLE CRYSTALS OR A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; APPARATUS THEREFOR
- C30B7/00—Single-crystal growth from solutions using solvents which are liquid at normal temperature, e.g. aqueous solutions
- C30B7/02—Single-crystal growth from solutions using solvents which are liquid at normal temperature, e.g. aqueous solutions by evaporation of the solvent
-
- C—CHEMISTRY; METALLURGY
- C30—CRYSTAL GROWTH
- C30B—SINGLE-CRYSTAL GROWTH; UNIDIRECTIONAL SOLIDIFICATION OF EUTECTIC MATERIAL OR UNIDIRECTIONAL DEMIXING OF EUTECTOID MATERIAL; REFINING BY ZONE-MELTING OF MATERIAL; PRODUCTION OF A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; SINGLE CRYSTALS OR HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; AFTER-TREATMENT OF SINGLE CRYSTALS OR A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; APPARATUS THEREFOR
- C30B7/00—Single-crystal growth from solutions using solvents which are liquid at normal temperature, e.g. aqueous solutions
- C30B7/14—Single-crystal growth from solutions using solvents which are liquid at normal temperature, e.g. aqueous solutions the crystallising materials being formed by chemical reactions in the solution
Abstract
The present invention relates to a novel co-crystal of the compound of formula (I): (Formula (I)) wherein the co-former molecule is bisphosphate hemihydrate, to processes for the preparation of the co-crystal, to pharmaceutical compositions containing the co-crystal, to the use of such a co-crystal in the manufacture of a medicament for use in the treatment of cancer and to methods of treating such diseases in the human or animal body by administering a therapeutically effective amount of such a co-crystal.
Claims (4)
1. A co-crystal of compound (I) and a co-former molecule, or a solvate of the co-crystal, wherein the co-former molecule is phosphoric acid.
2. The stal of claim 1, wherein the molar ratio of compound (I) : phosphoric acid in the co-crystal is 1:2.
3. The co-crystal of claim 1 or 2, wherein the co-crystal is a hydrate.
4. The co-crystal of any one of claims 1-3, wherein the molar ratio of nd (I) : phosphoric acid : H2O in the co-crystal is 1:2:
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662363424P | 2016-07-18 | 2016-07-18 | |
| PCT/CA2017/050848 WO2018014116A1 (en) | 2016-07-18 | 2017-07-13 | Solid forms of ttk inhibitor |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NZ749844A NZ749844A (en) | 2024-03-22 |
| NZ749844B2 true NZ749844B2 (en) | 2024-06-25 |
Family
ID=
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| MX2021004431A (en) | Novel processes. | |
| PH12019502436A1 (en) | 6-6 fused bicyclic heteroaryl compounds and their use as lats inhibitors | |
| MX2023003564A (en) | Compounds and their use in treating cancer. | |
| NZ777871A (en) | Small molecule modulators of il-17 | |
| MX2008013212A (en) | 4-anilinoquinoline-3-carboxamides as csf-1r kinase inhibitors. | |
| NZ708593A (en) | Novel pyrazole derivative | |
| MX2012012225A (en) | Nitric oxide releasing prodrugs of therapeutic agents. | |
| MX2022010520A (en) | Peptide macrocycles against acinetobacter baumannii. | |
| MX2009004908A (en) | Chemical compounds. | |
| UA86614C2 (en) | Compound having kinase ingibitor activity, pharmaceutical composition containing thereof and use thereof for the preparation of medicine | |
| NZ726366A (en) | Syk inhibitors | |
| MX2022006990A (en) | Crystalline form of a 7h-benzo[7]annulene-2-carboxylic acid derivative. | |
| SG10201810404XA (en) | Combination comprising a glucocorticoid and edo-s101 | |
| WO2014151630A3 (en) | Compounds and compositions for the treatment of parasitic diseases | |
| WO2018005801A3 (en) | Novel non-systemic tgr5 agonists | |
| PH12019500618A1 (en) | Pharmaceutical composition and method for treatment of non-alcoholic fatty liver disease | |
| EA201992090A1 (en) | Deuterated Imidazo [4,5-c] Quinolin-2-One Compounds and Their Use in Cancer Treatment | |
| WO2018005794A3 (en) | Novel non-systemic tgr5 agonists | |
| MX2024014315A (en) | Amido heteroaromatic compounds useful in the treatment of liver diseases | |
| MX2009007889A (en) | 3 - cinnolinecarboxamide derivatives and their use for treating cancer. | |
| PH12019500858A1 (en) | Combination therapy with a phosphoinositide 3-kinase inhibitor with a zinc binding moiety | |
| MX2021008658A (en) | Solid forms of ttk inhibitor. | |
| EP4620940A3 (en) | Synthesis of (+)-cannabinoids and their therapeutic effects | |
| RU2010120806A (en) | MONTELUKAST ACID INHALATION COMPOSITIONS AND PDE-4 INHIBITOR OR INHALATION CORTICOSTEROID | |
| NZ749844B2 (en) | Solid forms of ttk inhibitor |