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NZ752576B2 - Cyclic peptide tyrosine tyrosine compounds as modulators of neuropeptide y receptors - Google Patents
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NZ752576B2 - Cyclic peptide tyrosine tyrosine compounds as modulators of neuropeptide y receptors - Google Patents

Cyclic peptide tyrosine tyrosine compounds as modulators of neuropeptide y receptors

Info

Publication number
NZ752576B2
NZ752576B2 NZ752576A NZ75257617A NZ752576B2 NZ 752576 B2 NZ752576 B2 NZ 752576B2 NZ 752576 A NZ752576 A NZ 752576A NZ 75257617 A NZ75257617 A NZ 75257617A NZ 752576 B2 NZ752576 B2 NZ 752576B2
Authority
NZ
New Zealand
Prior art keywords
tyrosine
compounds
neuropeptide
modulators
receptors
Prior art date
Application number
NZ752576A
Other versions
NZ752576A (en
Inventor
Martin A Case
Mark Macielag
Raymond J Patch
Mark Wall
Rui Zhang
Yue Mei Zhang
Original Assignee
Janssen Pharmaceutica Nv
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Priority to NZ793477A priority Critical patent/NZ793477B2/en
Priority claimed from PCT/US2017/058451 external-priority patent/WO2018081367A1/en
Publication of NZ752576A publication Critical patent/NZ752576A/en
Publication of NZ752576B2 publication Critical patent/NZ752576B2/en

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    • C07K2317/55—Fab or Fab'
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    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
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    • C07K2317/567—Framework region [FR]
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    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/71—Decreased effector function due to an Fc-modification
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    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof

Abstract

The present invention comprises compounds of Formula I wherein: Z4, Z7, Z9, Z11, Z22, Z23, Z26, Z30, Z34, Z35, p, m, n, q, and BRIDGE are defined in the specification. The invention also relates to pharmaceutical compositions and methods for use thereof. The novel compounds are useful for preventing, treating or ameliorating diseases and disorders, such as obesity, type 2 diabetes, the metabolic syndrome, insulin resistance, and dyslipidemia, among others.

Claims (1)

1. Claims T
NZ752576A 2017-10-26 Cyclic peptide tyrosine tyrosine compounds as modulators of neuropeptide y receptors NZ752576B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
NZ793477A NZ793477B2 (en) 2017-10-26 Cyclic peptide tyrosine tyrosine compounds as modulators of neuropeptide y receptors

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662413586P 2016-10-27 2016-10-27
US201662413613P 2016-10-27 2016-10-27
PCT/US2017/058451 WO2018081367A1 (en) 2016-10-27 2017-10-26 Cyclic peptide tyrosine tyrosine compounds as modulators of neuropeptide y receptors

Publications (2)

Publication Number Publication Date
NZ752576A NZ752576A (en) 2025-09-26
NZ752576B2 true NZ752576B2 (en) 2026-01-06

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