NZ756590B2

NZ756590B2 - Liquid applicator for delivering vaccines

Info

Publication number: NZ756590B2
Application number: NZ756590A
Authority: NZ
Inventors: Frederic David; Malibran Santibanez Aurelie De; Masias Alonso Prado
Original assignee: Boehringer lngelheim Vetmedica GMBH
Filing date: 2018-02-13
Publication date: 2025-08-05

Abstract

The present disclosure is directed to liquid applicators and methods of use for delivering formulations, including vaccines, to animals. In particular, the present disclosure aims to overcome one or more shortcomings of existing devices currently used to deliver fluids to the mouths of animals which are not-well designed to provide safe and effective vaccination. This shortcoming is overcome, at least in part, by the provision of an improved, ergonomic, liquid applicator comprising a resilient and elongated reservoir and an angled stem, which can deliver fluids including vaccines, safely and effectively to animals in need thereof.

Claims

1. An applicator adapted to draw into and deliver a liquid composition to an animal per os, comprising: a resilient and elongated reservoir ng a longitudinal axis: an te, angled, hollow stem adapted to be inserted into the animal’s mouth, wherein the stem comprising proximal and distal ends, the proximal end operably connected to and in fluid communication with the reservoir, wherein the stem comprises a distal end adaptable to allow liquid to exit and enter the applicator; wherein the stem ses a first stem region being along the longitudinal axis and a second stem region angled with respect to the longitudinal axis by an angle theta (T), which is from about 15 to about 35 degrees, wherein the first stem region and the second stem region have a length ratio in a range between 10:1 to 1:10, and wherein the applicator is adapted to sealably contain a r liquid of the liquid composition to be dispensed to the animal, wherein the distal end of the stem is capable of delivering the carrier liquid to a vial containing a lyophilized immunogen such that the liquid composition is formed upon mixing of the carrier liquid with the lized immunogen, wherein the distal end is capable of retrieving at least some of the liquid composition from the vial, and wherein the applicator is capable of delivering at least a portion of the retrieved liquid composition to an animal to be vaccinated upon application of pressure to at least a n of the applicator.

2. A kit sing the applicator of claim 1, and a vial of lyophilized immunogen.

3. The ator or kit of claim 1 or claim 2, wherein the distal end comprises a frangible seal.

4. The applicator or kit of any one of claims 1 to 3, wherein theta is from about 20 to about 30 degrees.

5. The applicator or kit of any one of claims 1 to 4, wherein theta is about 25 degrees.

6. The applicator or kit of any one of claims 1 to 5, wherein the range of the length ratio of the first stem region and the second stem region is between 5:1 to 1:5.

7. The ator or kit of any one of claims 1 to 6, wherein the range of the length ratio of the first stem region and the second stem region is between 3:1 to 1:3.

8. The applicator or kit of any one of claims 1 to 7, wherein the range of the length ratio of the first stem region and the second stem region is between 2:1 to 1:2.

9. The applicator or kit of and one of claims 1 to 8, wherein the applicator contains the carrier liquid.

10. The applicator or kit of any one of claims 1 to 9, wherein the animal to be vaccinated is a canine.

11. The kit of any one of claim 2 to 10, n the lyophilized immunogen is for admixing with the carrier liquid to form a blended vaccine or immunogen formulation.

12. The kit of any one of claims 2 to 11, wherein the lyophilized immunogen induces immunity t a en selected from the group consisting of: an influenza, a parainfluenza, a canine influenza, bordetella, a rabies virus, a parvovirus, an adenovirus, or a pter.

13. The kit of any one of claims 2 to 12, wherein the vial is a sealed sterile 3 mL vial.

14. The kit of any one of claims 2 to 13, wherein the filling volume of the applicator is from about 1 mL to about 3 mL.

15. A method of vaccinating a non-human animal in need thereof comprising the steps of: a) providing an applicator according to any one of claim 1 or claims 3 to 8; b) breaking the frangible seal e.g., to allow a carrier liquid to be dispensed from the applicator; c) dispensing the r liquid into a vial containing lyophilized immunogen ; d) sufficiently blending the r liquid and lyophilized immunogen to produce a blended vaccine formulation; e) compressing the resilient reservoir; f ) inserting the open distal end into the vial such that the distal end is in fluid ication with the blended vaccine formulation; g) releasing the ssion of the ent reservoir, thereby drawing up the blended vaccine formulation through the stem, and optionally, into the resilient reservoir; h) inserting the distal end into the mouth of the animal to be vaccinated; i) compressing the resilient reservoir to administer the blended vaccine formulation inside the mouth of the non-human .

16. The method of claim 15, further sing providing the vial of lyophilized immunogen.

17. The method of claim 15 or claim 16, wherein after step b) and prior to step c), the process further comprises inserting the distal end of the ator into the vial containing lyophilized immunogen.

18. The method of claim 17, wherein after step d) and prior to step e), the process further comprising removing the distal end of the applicator from the blended vaccine formulation.

19. The method of any one of claims 15 to 18, wherein after step e) and prior to step f), the process r comprising ensuring that the distal end of the stem is open to the external environment after compressing the resilient reservoir.

20. The method of any one of claims 15 to 19, wherein the non-human animal is a canine.

21. The method of any one of claims 15 to 20, n the lyophilized immunogen induces immunity against a pathogen selected from the group consisting of: an influenza virus, a parainfluenza, a canine influenza, bordetella, a rabies virus, a parvovirus, an adenovirus, or a distempter.

22. The method of claim 21, wherein the pathogen is a bordetella.

23. The method of claim 22, wherein the bordetella is a bordetella bronchiseptica.

24. The method of any one of claims 15 to 23, wherein the vial is a sealed e 3 mL vial.

25. The method of any one of claims 15 to 24, wherein the filling volume of the applicator is from about 1 mL to about 3 mL.

26. The method of any one of claims 15 to 25, wherein the blended vaccine formulation is administered to a buccal and/or mucosal surface in the mouth.

27. Use of the applicator or kit of any one of claims 1 to 14, to ate a non-human animal in need thereof. ‘ v ( "WWW 9 « ‘r EL‘XWJo.