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NZ772085B2 - Anti-CD3 antibodies, anti-CD123 antibodies and bispecific antibodies specifically binding to CD3 and/or CD123 - Google Patents
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NZ772085B2 - Anti-CD3 antibodies, anti-CD123 antibodies and bispecific antibodies specifically binding to CD3 and/or CD123 - Google Patents

Anti-CD3 antibodies, anti-CD123 antibodies and bispecific antibodies specifically binding to CD3 and/or CD123 Download PDF

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Publication number
NZ772085B2
NZ772085B2 NZ772085A NZ77208516A NZ772085B2 NZ 772085 B2 NZ772085 B2 NZ 772085B2 NZ 772085 A NZ772085 A NZ 772085A NZ 77208516 A NZ77208516 A NZ 77208516A NZ 772085 B2 NZ772085 B2 NZ 772085B2
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NZ
New Zealand
Prior art keywords
amino acid
seq
acid sequence
length
antibody
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Application number
NZ772085A
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NZ772085A (en
Inventor
Jana Albrecht
Cedric Barriere
Christian Beil
Jochen Beninga
Chantal Carrez
Stephane Guerif
Katja Kroll
Christian Lange
Cendrine Lemoine
Wulf Dirk Leuschner
Original Assignee
Sanofi
Filing date
Publication date
Application filed by Sanofi filed Critical Sanofi
Priority claimed from NZ734803A external-priority patent/NZ734803A/en
Publication of NZ772085A publication Critical patent/NZ772085A/en
Publication of NZ772085B2 publication Critical patent/NZ772085B2/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2318/00—Antibody mimetics or scaffolds
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70596—Molecules with a "CD"-designation not provided for elsewhere in G01N2333/705
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/715—Assays involving receptors, cell surface antigens or cell surface determinants for cytokines; for lymphokines; for interferons
    • G01N2333/7155—Assays involving receptors, cell surface antigens or cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
    • G01N33/574—
    • G01N33/57492—

Abstract

The present invention concerns antibody-like binding protein specifically binding to CD3 and binding specifically to at least one further antigen, for example CD123. The present invention also concerns antibody-like binding protein specifically binding to CD123 and binding specifically to at least one further antigen. The invention further concerns anti-CD3 antibodies and anti-CD123 antibodies. The invention also relates to pharmaceutical compositions comprising the antibody-like binding protein, anti-CD3 antibodies or anti-CD123 antibodies of the invention, and their use to treat cancer. The invention further relates to isolated nucleic acids, vectors and host cells comprising a sequence encoding said antibody-like binding protein, anti-CD3 or anti-CD123 antibody and the use of said anti-CD123 antibody as a diagnostic tool.

Claims (29)

Claims
1. An antibody-like binding n that specifically binds to human CD3e and one other target antigen sing two polypeptide chains that form two antigen-binding sites, wherein a first polypeptide chain has a structure ented by the a [IV]: VD1-L1-VD2-L2-CL-L5-Fc2 [IV] and a second polypeptide chain has a structure represented by the formula [III]: VD3-L3-VD4-L4-CH1-Fc [III] wherein: VD1 is a heavy chain or light chain variable domain of a first immunoglobulin; VD2 is a heavy chain or light chain variable domain of a second immunoglobulin; VD3 is a heavy chain or light chain variable domain of the second immunoglobulin; VD4 is a heavy chain or light chain variable domain of the first immunoglobulin; CL is a light chain constant domain of an immunoglobulin; CH1 is a CH1 heavy chain constant domain of an immunoglobulin; Fc is the immunoglobulin hinge region and CH2, CH3 immunoglobulin heavy chain constant domains of an globulin; Fc2 is the immunoglobulin hinge region and CH2, CH3 immunoglobulin heavy chain constant domains of an immunoglobulin; and L1, L2, L3, L4, and L5 are amino acid s; wherein the first polypeptide and the second polypeptide form a over light chain-heavy chain pair; wherein VD1 and VD2 are both either variable domains of light chains, or variable domains of heavy chains, and VD3 and VD4 are both variable domains of heavy chains if VD1 and VD2 are variable domains of light chains, or VD3 and VD4 are both variable domains of light chains if VD1 and VD2 are variable domains of heavy chains; and wherein the first immunoglobulin or the second immunoglobulin is an anti-CD3 antibody comprising a heavy chain variable domain comprising a CDR1-H having the amino acid sequence of SEQ ID NO: 6, a CDR2-H having the amino acid sequence of SEQ ID NO: 7, 20944327_1 (GHMatters) P43116NZ02 and a CDR3-H having the amino acid sequence of SEQ ID NO: 8; and a light chain variable domain comprising a CDR1-L having the amino acid sequence of SEQ ID NO: 142, a CDR2- L having the amino acid sequence KVS, and a CDR3-L having the amino acid sequence of SEQ ID NO: 11.
2. An antibody-like binding protein that specifically binds to human CD3e and one other target antigen comprising three polypeptide chains that form two antigen-binding sites, wherein a first polypeptide has a structure represented by the formula [I]: VD1-L1-VD2-L2-CL [I] a second polypeptide has a ure represented by the formula [III]: VD3-L3-VD4-L4-CH1-Fc [III] and a third polypeptide Fc3, which is the immunoglobulin hinge region and CH2, CH3 immunoglobulin heavy chain constant s of an immunoglobulin; wherein VD1 is a heavy chain or light chain variable domain of a first globulin; VD2 is a heavy chain or light chain variable domain of a second globulin; VD3 is a heavy chain or light chain variable domain of the second immunoglobulin; VD4 is a heavy chain or light chain variable domain of the first immunoglobulin; CL is a light chain constant domain of an immunoglobulin; CH1 is a CH1 heavy chain constant domain of an globulin; Fc is the immunoglobulin hinge region and CH2, CH3 immunoglobulin heavy chain constant domains of an immunoglobulin; and L1, L2, L3, and L4 are amino acid linkers; wherein the first polypeptide and the second polypeptide form a cross-over light chain-heavy chain pair; wherein VD1 and VD2 are both either le s of light chains, or variable domains of heavy chains, and VD3 and VD4 are both variable domains of heavy chains if VD1 and VD2 are variable domains of light chains, or VD3 and VD4 are both variable domains of light chains if VD1 and VD2 are variable domains of heavy chains; 20944327_1 (GHMatters) P43116NZ02 wherein the second ptide dimerizes with the third polypeptide through its Fc domain; and wherein the first immunoglobulin or the second immunoglobulin is an anti-CD3 antibody comprising a heavy chain variable domain comprising a CDR1-H having the amino acid sequence of SEQ ID NO: 6, a CDR2-H having the amino acid sequence of SEQ ID NO: 7, and a CDR3-H having the amino acid sequence of SEQ ID NO: 8; and a light chain variable domain comprising a CDR1-L having the amino acid sequence of SEQ ID NO: 142, a CDR2- L having the amino acid sequence KVS, and a CDR3-L having the amino acid sequence of SEQ ID NO: 11.
3. The antibody-like binding protein of either claim 1 or 2, n: (a) VD1 consists of the amino acid sequence of SEQ ID NO: 141 or an amino acid sequence that is at least 85% identical thereto, and VD4 consists of the amino acid sequence of SEQ ID NO: 138 or an amino acid sequence that is at least 85% identical thereto; (b) VD1 consists of the amino acid sequence of SEQ ID NO: 138 or an amino acid sequence that is at least 85% cal thereto, and VD3 consists of the amino acid ce of SEQ ID NO: 141 or an amino acid sequence that is at least 85% identical thereto; (c) VD2 consists of the amino acid sequence of SEQ ID NO: 141 or an amino acid sequence that is at least 85% identical thereto, and VD3 consists of the amino acid sequence of SEQ ID NO: 138 or an amino acid sequence that is at least 85% identical thereto; or (d) VD2 consists of the amino acid sequence of SEQ ID NO: 138 or an amino acid sequence that is at least 85% identical thereto, and VD3 consists of the amino acid sequence of SEQ ID NO: 141 or an amino acid sequence that is at least 85% identical thereto.
4. The antibody-like g protein of either claim 1 or 2, n: (a) VD1 ts of an amino acid sequence that is 85% identical to the amino acid sequence of SEQ ID NO: 141 in which the CDR sequences of SEQ ID NO: 142, KVS, and SEQ ID NO: 11 are unaltered, and VD4 consists of an amino acid sequence that is 85% identical to the amino acid sequence of SEQ ID NO: 138 in which the CDR sequences of SEQ ID NO: 6, SEQ ID NO: 7, and SEQ ID NO: 8 are unaltered; (b) VD1 consists of an amino acid sequence that is 85% identical to the amino acid ce of SEQ ID NO: 138 in which the CDR sequences of SEQ ID NO: 6, SEQ ID 20944327_1 (GHMatters) P43116NZ02 NO: 7, and SEQ ID NO: 8 are unaltered, and VD3 consists of an amino acid ce that is 85% identical to the amino acid sequence of SEQ ID NO: 141 in which the CDR sequences of SEQ ID NO: 142, KVS, and SEQ ID NO: 11 are unaltered; (c) VD2 consists of an amino acid sequence that is 85% identical to the amino acid sequence of SEQ ID NO: 141 in which the CDR sequences of SEQ ID NO: 142, KVS, and SEQ ID NO: 11 are unaltered, and VD3 consists of an amino acid sequence that is 85% cal to the amino acid sequence of SEQ ID NO: 138 in which the CDR sequences of SEQ ID NO: 6, SEQ ID NO: 7, and SEQ ID NO: 8 are unaltered; or (d) VD2 consists of an amino acid sequence that is 85% cal to the amino acid sequence of SEQ ID NO: 138 in which the CDR sequences of SEQ ID NO: 6, SEQ ID NO: 7, and SEQ ID NO: 8 are red, and VD3 consists of an amino acid sequence that is 85% identical to the amino acid sequence of SEQ ID NO: 141 in which the CDR sequences of SEQ ID NO: 142, KVS, and SEQ ID NO: 11 are unaltered.
5. The antibody-like binding protein according to either claim 1 or 2, wherein the first and second immunoglobulins are IgG immunoglobulins.
6. The antibody-like binding protein ing to either claim 1 or 2, wherein CL is a light chain constant domain of an IgG immunoglobulin and/or CH1 is a CH1 heavy chain constant domain of an IgG immunoglobulin.
7. The antibody-like binding protein according to either claim 1 or 2, wherein: (a) the length of L3 is at least twice the length of L1; or (b) the length of L4 is at least twice the length of L2.
8. The antibody-like binding protein according to either claim 1 or 2, wherein: (a) the length of L1 is at least twice the length of L3; or (b) the length of L2 is at least twice the length of L4.
9. The antibody-like binding n according to either claim 1 or 2, wherein: L1 is 3 to 12 amino acid residues in length; 20944327_1 (GHMatters) P43116NZ02 L2 is 3 to 14 amino acid residues in length; L3 is 1 to 8 amino acid es in length; and L4 is 1 to 3 amino acid residues in length.
10. The antibody-like binding protein according to claim 9, wherein: L1 is 5 to 10 amino acid residues in length; L2 is 5 to 8 amino acid residues in length; L3 is 1 to 5 amino acid residues in length; and L4 is 1 to 2 amino acid residues in length.
11. The dy-like binding protein according to claim 10, wherein: L1 is 7 amino acid residues in length; L2 is 5 amino acid residues in length; L3 is 1 amino acid residues in length; and L4 is 2 amino acid residues in length.
12. The antibody-like binding protein ing to either claim 1 or 2, wherein: L1 is 1 to 3 amino acid residues in length; L2 is 1 to 4 amino acid residues in length; L3 is 2 to 15 amino acid residues in length; and L4 is 2 to 15 amino acid residues in length.
13. The antibody-like g protein according to claim 12, wherein: L1 is 1 to 2 amino acid residues in length; L2 is 1 to 2 amino acid es in length; L3 is 4 to 12 amino acid residues in length; and L4 is 2 to 12 amino acid residues in length.
14. The antibody-like g protein ing to claim 13, wherein: L1 is 1 amino acid residue in length; L2 is 2 amino acid residues in length; 20944327_1 (GHMatters) P43116NZ02 L3 is 7 amino acid residues in length; and L4 is 5 amino acid residues in .
15. The antibody-like binding protein according to either claim 1 or 2, wherein at least one of the linkers selected from the group ting of L1, L2, L3, and L4 contains at least one cysteine e.
16. The antibody-like binding protein according to either claim 1 or 2, wherein: (a) L1 is 0 amino acid es in length and L3 is at least 1 amino acid residue in length; (b) L3 is 0 amino acid residues in length and L1 is at least 1 amino acid residue in length; or (c) L4 is 0 amino acid residues in length and L2 is at least 1 amino acid residue in length.
17. The antibody-like binding protein according to claim 16, wherein L1 is 0 amino acid residues in length and L3 is 2 or more amino acid residues in length.
18. The antibody-like binding protein according to claim 16, wherein L4 is 0 amino acid residues in length and L2 is 3 or more amino acid residues in .
19. The antibody-like binding protein according to claim 1, wherein L5 is 0 to 10 amino acid residues in length.
20. The antibody-like binding protein according to claim 1, wherein Fc ses the amino acid sequence of SEQ ID NO: 394, and Fc2 comprises the amino acid sequence of SEQ ID NO: 392. 20944327_1 (GHMatters) P43116NZ02
21. The antibody-like binding protein according to claim 2, wherein both Fc and Fc3 are immunoglobulin variants in which the amino acid sequence of the CH3 domain has been modified to promote multimer formation.
22. The antibody-like binding protein according to claim 2, wherein the CH3 domain of one of Fc and Fc3 contains the amino acid mutations Y349C, T366S, L368A, and Y407V, and the CH3 domain of the other of Fc and Fc3 contains the amino acid ons S354C and T366W.
23. The antibody-like binding protein according to claim 2, wherein: (a) Fc ses the amino acid sequence of SEQ ID NO: 396, and Fc3 ses the amino acid sequence of SEQ ID NO: 397; and (b) Fc comprises the amino acid sequence of SEQ ID NO: 394, and Fc3 comprises the amino acid sequence of SEQ ID NO: 398.
24. A pharmaceutical composition comprising an antibody-like binding protein according to any one of claims 1 to 23 and a pharmaceutically acceptable r.
25. An isolated nucleic acid comprising a sequence encoding an antibody-like binding protein according to any one of claims 1 to 23.
26. An expression vector sing the nucleic acid molecule according to claim 25.
27. An isolated host cell which has been transfected, infected, or transformed by the c acid according to claim 25.
28. An isolated host cell which has been transfected, infected, or transformed by the expression vector according to claim 26. 20944327_1 (GHMatters) P43116NZ02
29. A kit comprising at least one antibody-like binding protein according to any one of claims 1 to 23. 27_1 (GHMatters) P43116NZ02 ????
NZ772085A 2016-01-22 Anti-CD3 antibodies, anti-CD123 antibodies and bispecific antibodies specifically binding to CD3 and/or CD123 NZ772085B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP15305077 2015-01-23
NZ734803A NZ734803A (en) 2015-01-23 2016-01-22 Anti-cd3 antibodies, anti-cd123 antibodies and bispecific antibodies specifically binding to cd3 and/or cd123

Publications (2)

Publication Number Publication Date
NZ772085A NZ772085A (en) 2024-07-05
NZ772085B2 true NZ772085B2 (en) 2024-10-08

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