NZ799580B2

NZ799580B2 - Auto-injector

Info

Publication number: NZ799580B2
Application number: NZ799580A
Authority: NZ
Inventors: Rachel Arnott; Scott Barton; Bart E Burgess; Richard Gildersleeve; Alexei Goraltchouk; Bryan C Grygus; Daniel Halbig; Christopher Kanel; Trevor Langley; Alfred Marino
Original assignee: Regeneron Pharmaceuticals Inc
Filing date: 2018-05-04
Publication date: 2025-09-02

Abstract

injection device includes a housing, a container within the housing enclosing a medicament, and a fluid conduit with a piercing end. The piercing end is configured to move from an undeployed position with the fluid conduit being entirely contained within the housing, to a deployed configuration with the piercing end of the fluid conduit extending outside of the housing. Movement of the container relative to the housing and the piercing end of the fluid conduit causes the piecing end of the fluid conduit to move from the deployed position to a third position wherein the piercing end is retracted within the housing. The fluid conduit of the current invention reduces the amount of material that contacts the drugs and hence require less sterilization than conventional devices.

Claims

THE CLAIMS DEFINING THE INVENTION ARE AS FOLLOWS:

1. An injection device, comprising: a housing; a container disposed within the housing, the ner enclosing a medicament; and a fluid conduit having a piercing end, n the piercing end is configured to move from an oyed position where the fluid conduit is entirely contained within the g, to a deployed position where the ng end of the fluid conduit extends outside of the housing; wherein movement of the container relative to the housing and relative to the piercing end of the fluid t is configured to cause the piercing end of the fluid conduit to move from the deployed position to a third position where the piercing end of the fluid conduit is retracted within the housing.

2. The injection device of claim 1, wherein the undeployed position and the third position are different.

3. The injection device of any one of the ing claims, further including a piston disposed within the container, wherein movement of the piston in a first direction from a first end of the container toward a second end of the container, while the piercing end of the fluid conduit is in the deployed position, urges medicament out of the container and into the fluid conduit.

4. The injection device of claim 3, wherein movement of the container in a second direction, opposite of the first direction, causes the piercing end of the fluid conduit to move from the deployed position to the third position.

5. The injection device of claim 4, further including: a motor configured to drive the piston; and a controller coupled to the motor, wherein the controller is ured to: send a first signal to the motor to drive the piston in the first direction; send a second signal to the motor to drive the piston in the second

6. The injection device of claim 5, wherein the ller is ured to send the second signal without requiring any intervention by a user after sending the first signal.

7. The injection device of any one of the preceding , further including: a driver coupled to the fluid conduit, the driver being slidable relative to the housing between a retracted configuration and a deployed configuration; a shuttle configured to move the driver n the retracted configuration and the deployed configuration; and a stop configured to move from a first configuration to a second configuration, wherein: the stop is configured to maintain the driver in the deployed configuration, movement of the stop from the first configuration to the second configuration allows the shuttle to move the driver from the deployed configuration to the retracted configuration, and movement of the container causes the stop to move from the first configuration to the second configuration.

8. The ion device of claim 7, wherein movement of the stop from the first configuration to the second configuration includes n of the stop about a fixed

9. The ion device of claim 8, wherein the stop includes a free end movable relative to the fixed end of the stop, and the stop is configured to maintain the driver in the deployed configuration when the free end of the stop contacts the shuttle.

10. The injection device of claim 9, wherein the flexion of the stop about the fixed end moves the free end of the stop out of t with the shuttle, allowing the shuttle to move the driver from the deployed configuration to the retracted configuration.

11. The injection device of any one of claims 8-10, wherein: the stop includes a first inclined surface; the injection device further includes a ramp having a second inclined surface that abuts the first inclined surface; and movement of the container is configured to push the ramp against the stop to cause the n of the stop.

12. The injection device of any one of claims 8-11, further ing a carrier inside the housing, wherein: the carrier includes the stop; and the shuttle is movable relative to the carrier.

13. The injection device of any one of claims 7-12, wherein the shuttle is e from a first position to a second position, and from the second position to a third position, wherein: when the shuttle is in the first position, the driver is in the retracted configuration; when the shuttle is in the second position, the driver is in the deployed configuration; and when the shuttle is in the third position, the driver is in the retracted configuration.

14. The injection device of claim 13, wherein the first position and the third position are different.

15. The ion device of claim 14, wherein the e moves in one direction along an axis to move from the first position to the second position, and from the second position to the third position.

16. The injection device of claim 15, wherein the shuttle is configured to move only in the one direction.

17. The injection device of claim 1, n: the container includes a first end and a second end; and the injection device further comprises a piston sealing the first end of the container, wherein the piston is movable through the container, in a first direction from the first end toward the second end of the container, to dispense the ment.

18. The injection device of claim 17, n the undeployed position and the third position are different.

19. A method of operating the ion device of claim 1, the method comprising: activating the injection device to cause the piercing end of the fluid conduit to move from being entirely enclosed within the housing of the injection device, to extending outside of the housing; wherein ting the injection device further causes: (1) the medicament to be dispensed from the container into the fluid conduit, while the piercing end of the fluid t is disposed outside of the housing, wherein the container is ly disposed within the housing; and (2) the container to move relative to the housing to cause the piercing end of the fluid conduit to retract entirely into the housing.

20. The method of claim 19, wherein the medicament is dispensed and the container is moved without any onal intervention after activating the injection

21. A method for ring the medicament from the injection device of claim 1, the method comprising: upon activation of the injection device: (1) extending the piercing end of the fluid t from being entirely enclosed within the housing of the injection device, to outside of the housing; (2) dispensing medicament from the container into the fluid conduit while the piercing end of the fluid conduit is disposed outside of the housing, wherein the container is entirely disposed within the housing; and (3) moving the container relative to the housing to cause the piercing end of the fluid conduit to retract ly into the housing.

22. The method of claim 21, wherein activation of the injection device occurs by pressing a button coupled to the housing.

23. The injection device of claim 1, further comprising: a plurality of lights d to the g; and a controller configured to: in response to activation of the injection device, cause the piercing end of the fluid conduit to extend outside of the housing; and during an injection sequence, cause each of the plurality of lights to be illuminated sequentially to te progress of the injection sequence.

24. The injection device of any one of claims 1-6, further comprising: a shuttle configured to cause the piercing end of the fluid conduit to move n the undeployed position and the deployed position; and a stop configured to impede movement of the shuttle, wherein the movement of the container relative to the g and relative to the piercing end of the fluid conduit is further configured to cause the stop to move from a path of the shuttle, such that the shuttle causes the ng end of the fluid conduit to move from the deployed position to the third position. SUBSTITUTE SHEET (RULE 26) SUBSTITUTE SHEET (RULE 26) SUBSTITUTE SHEET (RULE 26) SUBSTITUTE SHEET (RULE 26) Transiatian “$355 ‘ E Tauch g Sensar SUBSTITUTE SHEET (RULE 26) ‘ESGZ SUBSTITUTE SHEET (RULE 26) SUBSTITUTE SHEET (RULE 26) SUBSTITUTE SHEET (RULE 26) SUBSTITUTE SHEET (RULE 26)