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SE8207479L - PROCEDURE FOR PREPARING NEW BICYCLIC ASSOCIATIONS - Google Patents
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SE8207479L - PROCEDURE FOR PREPARING NEW BICYCLIC ASSOCIATIONS - Google Patents

PROCEDURE FOR PREPARING NEW BICYCLIC ASSOCIATIONS

Info

Publication number
SE8207479L
SE8207479L SE8207479A SE8207479A SE8207479L SE 8207479 L SE8207479 L SE 8207479L SE 8207479 A SE8207479 A SE 8207479A SE 8207479 A SE8207479 A SE 8207479A SE 8207479 L SE8207479 L SE 8207479L
Authority
SE
Sweden
Prior art keywords
general formula
image
group
compound
reacted
Prior art date
Application number
SE8207479A
Other languages
Swedish (sv)
Other versions
SE8207479D0 (en
Inventor
K Lempert
G Doleschall
J Fetter
G Hornyak
P Huszthy
J Nyitrai
G Simig
K Zauer
T Gizur
K Harsanyi
G Fekete
L Szporny
G Hajos
Original Assignee
Richter Gedeon Vegyeszet
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Vegyeszet filed Critical Richter Gedeon Vegyeszet
Publication of SE8207479D0 publication Critical patent/SE8207479D0/en
Publication of SE8207479L publication Critical patent/SE8207479L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
    • C07D207/277—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D411/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D411/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D411/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/02—Preparation
    • C07D477/04—Preparation by forming the ring or condensed ring systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Bicyclic compounds of the general formula (I), <IMAGE> wherein Y<1> and Y<2> represent a removable carbonyl protecting group, and Q is a C1-5 alkyl group or a substituted benzyl group, are prepared in such a way that a) a compound of the general formula (V), <IMAGE> wherein Y<1> and Y<2> are as defined above and R' is a removable amido protecting group other than phenyl group, is activated on the carboxy group and then reacted with a salt of a malonic acid hemiester, wherein the alcohol component is a C1-5 aliphatic alcohol or a substituted benzyl alcohol, the resulting new compound of the general formula (IV), <IMAGE> wherein R', Q, Y<1> and Y<2> are as defined above, is reacted with a sulfonic azide in the presence of a tertiary amine, or b) a compound of the general formula (V) is activated on its carboxy group and reacted then with a diazoacetic acid ester, thereafter the R' protecting group of a resulting new compound of the general formula (III> <IMAGE> is removed, and the resulting compound of the general formula (II> <IMAGE> is subjected to ring closure to form the desired end-product.
SE8207479A 1981-12-30 1982-12-29 PROCEDURE FOR PREPARING NEW BICYCLIC ASSOCIATIONS SE8207479L (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU814016A HU185492B (en) 1981-12-30 1981-12-30 Process for producing new azetidinyl-butanoates

Publications (2)

Publication Number Publication Date
SE8207479D0 SE8207479D0 (en) 1982-12-29
SE8207479L true SE8207479L (en) 1983-07-01

Family

ID=10966525

Family Applications (1)

Application Number Title Priority Date Filing Date
SE8207479A SE8207479L (en) 1981-12-30 1982-12-29 PROCEDURE FOR PREPARING NEW BICYCLIC ASSOCIATIONS

Country Status (18)

Country Link
JP (1) JPS58118589A (en)
AT (1) AT376218B (en)
AU (1) AU9197282A (en)
BE (1) BE895491A (en)
CA (1) CA1191854A (en)
DE (1) DE3248677A1 (en)
ES (1) ES518724A0 (en)
FI (1) FI824521L (en)
FR (1) FR2519003A1 (en)
GB (1) GB2114123B (en)
GR (1) GR77072B (en)
HU (1) HU185492B (en)
IT (1) IT1218332B (en)
LU (1) LU84570A1 (en)
NL (1) NL8205066A (en)
PL (1) PL239883A1 (en)
SE (1) SE8207479L (en)
ZA (1) ZA829599B (en)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0023097B1 (en) * 1979-06-28 1984-08-01 Sumitomo Chemical Company, Limited De-arylmethylation of n-mono- or n-diarylmethyl-beta-lactams; novel azetizinones having anti-bacterial activity
IE52147B1 (en) * 1980-03-27 1987-07-08 Merck & Co Inc 4-(3-carboxy-2-oxopropyl)-azetidin-2-ones and process for their preparation

Also Published As

Publication number Publication date
NL8205066A (en) 1983-07-18
ZA829599B (en) 1983-10-26
GB2114123A (en) 1983-08-17
ES8406481A1 (en) 1984-07-16
GR77072B (en) 1984-09-05
GB2114123B (en) 1985-10-02
BE895491A (en) 1983-06-28
IT8225064A0 (en) 1982-12-30
FR2519003A1 (en) 1983-07-01
AU9197282A (en) 1983-07-07
FI824521A7 (en) 1983-07-01
ES518724A0 (en) 1984-07-16
LU84570A1 (en) 1984-10-22
FI824521A0 (en) 1982-12-30
JPS58118589A (en) 1983-07-14
FI824521L (en) 1983-07-01
CA1191854A (en) 1985-08-13
SE8207479D0 (en) 1982-12-29
HU185492B (en) 1985-02-28
IT1218332B (en) 1990-04-12
DE3248677A1 (en) 1983-07-07
PL239883A1 (en) 1984-01-02
AT376218B (en) 1984-10-25
ATA453582A (en) 1984-03-15

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