SG11201405628YA - Conformationally constrained, fully synthetic macrocyclic compounds - Google Patents
Conformationally constrained, fully synthetic macrocyclic compoundsInfo
- Publication number
- SG11201405628YA SG11201405628YA SG11201405628YA SG11201405628YA SG11201405628YA SG 11201405628Y A SG11201405628Y A SG 11201405628YA SG 11201405628Y A SG11201405628Y A SG 11201405628YA SG 11201405628Y A SG11201405628Y A SG 11201405628YA SG 11201405628Y A SG11201405628Y A SG 11201405628YA
- Authority
- SG
- Singapore
- Prior art keywords
- fully synthetic
- macrocyclic compounds
- conformationally constrained
- synthetic macrocyclic
- conformationally
- Prior art date
Links
- 150000002678 macrocyclic compounds Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D273/00—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00
- C07D273/02—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00 having two nitrogen atoms and only one oxygen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
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-
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D291/00—Heterocyclic compounds containing rings having nitrogen, oxygen and sulfur atoms as the only ring hetero atoms
- C07D291/08—Heterocyclic compounds containing rings having nitrogen, oxygen and sulfur atoms as the only ring hetero atoms condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D515/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D515/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D515/06—Peri-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D515/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D515/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D515/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D515/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D515/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
- C07D515/18—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D515/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D515/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains four or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Dermatology (AREA)
- Cardiology (AREA)
- Endocrinology (AREA)
- Physical Education & Sports Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Psychiatry (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Obesity (AREA)
- Pain & Pain Management (AREA)
- Vascular Medicine (AREA)
- Reproductive Health (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Ophthalmology & Optometry (AREA)
- Transplantation (AREA)
- Child & Adolescent Psychology (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12001830 | 2012-03-17 | ||
| PCT/EP2013/055368 WO2013139697A1 (en) | 2012-03-17 | 2013-03-15 | Conformationally constrained, fully synthetic macrocyclic compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201405628YA true SG11201405628YA (en) | 2014-10-30 |
Family
ID=47882188
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201405628YA SG11201405628YA (en) | 2012-03-17 | 2013-03-15 | Conformationally constrained, fully synthetic macrocyclic compounds |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US10017481B2 (en) |
| EP (1) | EP2836485B1 (en) |
| JP (1) | JP6111276B2 (en) |
| CN (1) | CN104284891B (en) |
| AU (1) | AU2013234499B2 (en) |
| CA (1) | CA2867494C (en) |
| DK (1) | DK2836485T3 (en) |
| IL (1) | IL234595A (en) |
| MX (1) | MX361923B (en) |
| NZ (1) | NZ630901A (en) |
| SG (1) | SG11201405628YA (en) |
| WO (1) | WO2013139697A1 (en) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL2132221T3 (en) | 2007-02-28 | 2011-04-29 | Polyphor Ltd | Template-fixed peptidomimetics |
| KR102569226B1 (en) * | 2014-10-13 | 2023-08-22 | 아트린 파마슈티컬스 엘엘씨 | Ataxia telengiectasia and rad3-related (atr) protein kinase inhibitors |
| GB201509006D0 (en) * | 2015-05-26 | 2015-07-08 | Redx Pharma Plc | Antibacterial compounds |
| WO2017063755A1 (en) | 2015-10-12 | 2017-04-20 | Polyphor Ag | Conformationally constrained macrocyclic compounds |
| WO2017063757A1 (en) | 2015-10-12 | 2017-04-20 | Polyphor Ag | Conformationally constrained macrocyclic compounds |
| WO2017063754A1 (en) | 2015-10-12 | 2017-04-20 | Polyphor Ag | Conformationally constrained macrocyclic compounds as pin1 modulators |
| GB201705686D0 (en) * | 2017-04-07 | 2017-05-24 | Centauri Therapeutics Ltd | Novel compounds and therapeutic uses thereof |
| FI4065585T3 (en) | 2019-11-25 | 2025-09-26 | Alkermes Inc | Substituted macrocyclic compounds and related methods of treatment |
| JP7766028B2 (en) * | 2020-06-03 | 2025-11-07 | 中外製薬株式会社 | Efficient peptide condensation method for difficult sequences |
| US11760747B2 (en) | 2020-12-21 | 2023-09-19 | Alkermes, Inc. | Substituted piperidino compounds and related methods of treatment |
| US12006330B2 (en) | 2020-12-21 | 2024-06-11 | Alkermes, Inc. | Substituted macrocyclic compounds and related methods of treatment |
| US20260022142A1 (en) * | 2022-05-20 | 2026-01-22 | Bristol-Myers Squibb Company | Macrocyclic immunomodulators |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2399247A1 (en) * | 1977-08-04 | 1979-03-02 | Rhone Poulenc Ind | ANTIBIOTIC 35665 RP, ITS PREPARATION AND THE COMPOSITIONS CONTAINING THEM |
| JPS6016236B2 (en) | 1977-11-18 | 1985-04-24 | 武田薬品工業株式会社 | Production method of antibiotic C-15003 P-3 |
| SG158899A1 (en) * | 2005-01-13 | 2010-02-26 | Univ Wollongong | Peptidic compounds |
| MX2009008756A (en) * | 2007-03-01 | 2009-08-27 | Chugai Pharmaceutical Co Ltd | Macrocyclic compound. |
| US7732434B2 (en) * | 2007-04-20 | 2010-06-08 | Bristol-Myers Squibb Company | Macrocyclic acyl guanidines as beta-secretase inhibitors |
| EP2429568B1 (en) * | 2009-05-13 | 2016-08-17 | Enanta Pharmaceuticals, Inc. | Macrocyclic compounds as hepatitis c virus inhibitors |
| ES2530519T3 (en) * | 2009-08-05 | 2015-03-03 | Polyphor Ag | Completely synthetic macrocyclic compounds, with restricted conformation |
-
2013
- 2013-03-15 US US14/385,689 patent/US10017481B2/en active Active
- 2013-03-15 AU AU2013234499A patent/AU2013234499B2/en not_active Ceased
- 2013-03-15 SG SG11201405628YA patent/SG11201405628YA/en unknown
- 2013-03-15 EP EP13709234.2A patent/EP2836485B1/en active Active
- 2013-03-15 WO PCT/EP2013/055368 patent/WO2013139697A1/en not_active Ceased
- 2013-03-15 CA CA2867494A patent/CA2867494C/en active Active
- 2013-03-15 DK DK13709234.2T patent/DK2836485T3/en active
- 2013-03-15 JP JP2014561464A patent/JP6111276B2/en not_active Expired - Fee Related
- 2013-03-15 MX MX2014011078A patent/MX361923B/en active IP Right Grant
- 2013-03-15 CN CN201380024808.7A patent/CN104284891B/en active Active
- 2013-03-15 NZ NZ630901A patent/NZ630901A/en not_active IP Right Cessation
-
2014
- 2014-09-11 IL IL234595A patent/IL234595A/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| HK1206032A1 (en) | 2015-12-31 |
| JP6111276B2 (en) | 2017-04-05 |
| MX361923B (en) | 2018-12-19 |
| JP2015509970A (en) | 2015-04-02 |
| NZ630901A (en) | 2015-09-25 |
| IL234595A (en) | 2016-08-31 |
| CN104284891A (en) | 2015-01-14 |
| MX2014011078A (en) | 2014-11-21 |
| US10017481B2 (en) | 2018-07-10 |
| DK2836485T3 (en) | 2018-04-23 |
| AU2013234499B2 (en) | 2017-07-27 |
| US20150051183A1 (en) | 2015-02-19 |
| AU2013234499A1 (en) | 2014-10-09 |
| WO2013139697A1 (en) | 2013-09-26 |
| CN104284891B (en) | 2018-04-17 |
| EP2836485B1 (en) | 2018-01-10 |
| CA2867494C (en) | 2020-03-24 |
| CA2867494A1 (en) | 2013-09-26 |
| EP2836485A1 (en) | 2015-02-18 |
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| GB201204383D0 (en) | H, level | |
| GB201219690D0 (en) | New compounds l | |
| GB201207426D0 (en) | . |