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SG11201501790VA - Multi-organ-chip with improved life time and homoeostasis - Google Patents
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SG11201501790VA - Multi-organ-chip with improved life time and homoeostasis - Google Patents

Multi-organ-chip with improved life time and homoeostasis

Info

Publication number
SG11201501790VA
SG11201501790VA SG11201501790VA SG11201501790VA SG11201501790VA SG 11201501790V A SG11201501790V A SG 11201501790VA SG 11201501790V A SG11201501790V A SG 11201501790VA SG 11201501790V A SG11201501790V A SG 11201501790VA SG 11201501790V A SG11201501790V A SG 11201501790VA
Authority
SG
Singapore
Prior art keywords
homoeostasis
organ
chip
life time
improved life
Prior art date
Application number
SG11201501790VA
Inventor
Uwe Marx
Original Assignee
Tissuse Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tissuse Gmbh filed Critical Tissuse Gmbh
Publication of SG11201501790VA publication Critical patent/SG11201501790VA/en

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5082Supracellular entities, e.g. tissue, organisms
    • G01N33/5088Supracellular entities, e.g. tissue, organisms of vertebrates
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502746Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means for controlling flow resistance, e.g. flow controllers, baffles or throttle valves
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502761Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads or physically stretching molecules
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M21/00Bioreactors or fermenters specially adapted for specific uses
    • C12M21/08Bioreactors or fermenters specially adapted for specific uses for producing artificial tissue or for ex-vivo cultivation of tissue
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00Constructional details, e.g. recesses, hinges
    • C12M23/02Form or structure of the vessel
    • C12M23/04Flat or tray type, drawers
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00Constructional details, e.g. recesses, hinges
    • C12M23/02Form or structure of the vessel
    • C12M23/16Microfluidic devices; Capillary tubes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00Constructional details, e.g. recesses, hinges
    • C12M23/22Transparent or translucent parts
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00Constructional details, e.g. recesses, hinges
    • C12M23/24Gas permeable parts
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00Constructional details, e.g. recesses, hinges
    • C12M23/34Internal compartments or partitions
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00Constructional details, e.g. recesses, hinges
    • C12M23/40Manifolds; Distribution pieces
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00Constructional details, e.g. recesses, hinges
    • C12M23/48Holding appliances; Racks; Supports
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00Means for introduction, extraction or recirculation of materials, e.g. pumps
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/26Means for regulation, monitoring, measurement or control, e.g. flow regulation of pH
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/40Means for regulation, monitoring, measurement or control, e.g. flow regulation of pressure
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/46Means for regulation, monitoring, measurement or control, e.g. flow regulation of cellular or enzymatic activity or functionality, e.g. cell viability
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/08Geometry, shape and general structure
    • B01L2300/0809Geometry, shape and general structure rectangular shaped
    • B01L2300/0816Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00Moving or stopping fluids
    • B01L2400/04Moving fluids with specific forces or mechanical means
    • B01L2400/0475Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0481Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure squeezing of channels or chambers
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00Moving or stopping fluids
    • B01L2400/06Valves, specific forms thereof
    • B01L2400/0633Valves, specific forms thereof with moving parts
    • B01L2400/0655Valves, specific forms thereof with moving parts pinch valves
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00Moving or stopping fluids
    • B01L2400/08Regulating or influencing the flow resistance
    • B01L2400/082Active control of flow resistance, e.g. flow controllers
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M27/00Means for mixing, agitating or circulating fluids in the vessel

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Sustainable Development (AREA)
  • General Engineering & Computer Science (AREA)
  • Clinical Laboratory Science (AREA)
  • Analytical Chemistry (AREA)
  • Hematology (AREA)
  • Dispersion Chemistry (AREA)
  • Molecular Biology (AREA)
  • Cell Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Urology & Nephrology (AREA)
  • Fluid Mechanics (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Toxicology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Prostheses (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
SG11201501790VA 2012-09-28 2013-08-15 Multi-organ-chip with improved life time and homoeostasis SG11201501790VA (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261706928P 2012-09-28 2012-09-28
EP12186550.5A EP2712918B1 (en) 2012-09-28 2012-09-28 Multi-organ-chip with improved life time and homoeostasis
PCT/EP2013/067073 WO2014048637A1 (en) 2012-09-28 2013-08-15 Multi-organ-chip with improved life time and homoeostasis

Publications (1)

Publication Number Publication Date
SG11201501790VA true SG11201501790VA (en) 2015-04-29

Family

ID=47010306

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201501790VA SG11201501790VA (en) 2012-09-28 2013-08-15 Multi-organ-chip with improved life time and homoeostasis

Country Status (16)

Country Link
US (1) US9791433B2 (en)
EP (2) EP2712918B1 (en)
JP (1) JP6129973B2 (en)
KR (1) KR102067311B1 (en)
CN (1) CN104685048B (en)
AU (1) AU2013323042B2 (en)
BR (1) BR112015006859B1 (en)
CA (1) CA2885375C (en)
DK (1) DK2712918T3 (en)
ES (1) ES2529994T3 (en)
IL (1) IL237969A0 (en)
IN (1) IN2015DN02765A (en)
PT (1) PT2712918E (en)
RU (1) RU2630667C2 (en)
SG (1) SG11201501790VA (en)
WO (1) WO2014048637A1 (en)

Families Citing this family (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9719068B2 (en) 2010-05-06 2017-08-01 Children's Hospital Medical Center Methods and systems for converting precursor cells into intestinal tissues through directed differentiation
US10023832B2 (en) 2013-07-16 2018-07-17 Vanderbilt University Interconnections of multiple perfused engineered tissue constructs and microbioreactors, multi-microformulators and applications of the same
SG10201801654RA (en) 2014-05-28 2018-04-27 Childrens Hospital Med Ct Methods and systems for converting precursor cells into gastric tissues through directed differentiation
JP6439115B2 (en) * 2014-06-10 2018-12-19 一般財団法人生産技術研究奨励会 How to develop and maintain the function of tissue fragments
AU2015331848B2 (en) 2014-10-17 2022-03-03 Children's Hospital Medical Center, D/B/A Cincinnati Children's Hospital Medical Center In vivo model of human small intestine using pluripotent stem cells and methods of making and using same
RU2584598C1 (en) * 2015-03-27 2016-05-20 Общество с ограниченной ответственностью Научно-технический центр "БиоКлиникум" Microfluid chip for creation of mammalian organ cell models
CN104826676B (en) * 2015-05-04 2016-08-24 清华大学深圳研究生院 Micro-fluidic chip, system and application thereof
EP3415611B1 (en) * 2016-01-07 2025-05-14 Vanderbilt University Multi-microformulators and applications of the same
WO2017123855A1 (en) * 2016-01-13 2017-07-20 President And Fellows Of Harvard College Microfluidic sample devices and uses thereof
RU171690U1 (en) * 2016-03-24 2017-06-09 Общество с ограниченной ответственностью Научно-технический центр "БиоКлиникум" Microfluidic Chip for the Creation of Cellular Models of Mammalian Organs
CN109415685B (en) 2016-05-05 2023-07-04 儿童医院医疗中心 Method for producing gastric fundus tissue in vitro and compositions related thereto
US11078898B2 (en) * 2016-05-24 2021-08-03 Somavac Medical Solutions, Inc. Portable device with disposable reservoir for collection of internal fluid after surgery
EP4253956A3 (en) * 2016-10-14 2023-12-06 Wake Forest University Health Sciences Multi-organ "body on a chip" apparatus utilizing a common media
EP4553082A3 (en) 2016-11-04 2025-08-20 Children's Hospital Medical Center Liver organoid compositions and methods of making and using same
JP7583524B2 (en) * 2016-11-23 2024-11-14 モルフォセル テクノロジーズ インコーポレイテッド Encapsulated liver tissue
KR102492455B1 (en) 2016-11-24 2023-01-27 알베오릭스 테크놀러지스 아게 Cell culture systems and methods
EP3548507A4 (en) 2016-12-05 2020-07-15 Children's Hospital Medical Center COLON ORGANOIDS AND METHOD FOR THE PRODUCTION AND USE THEREOF
KR101970125B1 (en) 2017-01-16 2019-04-18 한림대학교 산학협력단 Stretchable skin-on-a-chips
JP7265988B2 (en) * 2017-02-03 2023-04-27 コーネル ユニヴァーシティー Stable three-dimensional blood vessel and method for forming same
CN106859716B (en) * 2017-03-02 2023-03-14 福建医科大学附属协和医院 Pancreas intestines anastomat
JP7248586B2 (en) 2017-04-14 2023-03-29 チルドレンズ ホスピタル メディカル センター Multi-Donor Stem Cell Compositions and Methods of Making Them
CN110997024A (en) * 2017-06-09 2020-04-10 哈佛大学的校长及成员们 Methods of enhancing renal organoid development and methods of using the same
CN107312711B (en) * 2017-06-26 2020-02-07 清华大学深圳研究生院 Self-circulation tissue/organ chip device and manufacturing method thereof
EP3694603B1 (en) 2017-10-10 2026-04-08 Children's Hospital Medical Center Esophageal tissue and/or organoid compositions and methods of making same
SG11202003790PA (en) * 2017-10-31 2020-05-28 Murdoch Childrens Res Inst Composition and method
EP3727394A4 (en) 2017-12-21 2021-09-08 Children's Hospital Medical Center DIGITIZED HUMAN ORGANOIDS AND METHODS OF USING THEM
US12038432B2 (en) 2018-02-02 2024-07-16 Wake Forest University Health Sciences Organoids related to immunotherapy and methods of preparing and using the same
US11731126B2 (en) 2018-04-19 2023-08-22 Nanyang Technological University Microfluidic board and method of forming the same
WO2019222871A1 (en) * 2018-05-21 2019-11-28 深圳华大生命科学研究院 Bionic intestinal-hepatic organ chip, preparation method therefor and application thereof
EP4678727A3 (en) 2018-07-26 2026-03-11 Children's Hospital Medical Center Hepato-biliary-pancreatic tissues and methods of making same
JP7545977B2 (en) * 2018-09-08 2024-09-05 アルプビジョン、ソシエテアノニム Method and system for cognitive computing based on biological neural networks
CA3112026A1 (en) 2018-09-12 2020-03-19 Children's Hospital Medical Center Organoid compositions for the production of hematopoietic stem cells and derivatives thereof
WO2020081740A1 (en) 2018-10-17 2020-04-23 Northwestern University Tissue culture platform having multiple well chambers fluidically coupled via microfluidic channels and selector valves
CN109337813B (en) * 2018-10-19 2023-07-11 杭州捷诺飞生物科技股份有限公司 System and method suitable for biological tissue culture and real-time monitoring
WO2020087148A1 (en) * 2018-11-02 2020-05-07 Centro Nacional De Pesquisa Em Energia E Materiais – Cnpem Platform for multi-systems culture, bioreactors and methods for in vitro experimental assays
CN111269830B (en) * 2018-12-05 2022-07-15 中国科学院大连化学物理研究所 Multi-organ chip based on microfluidic technology and application thereof
CN109517739A (en) * 2018-12-27 2019-03-26 重庆大学 Double organs are coupled three-layer laminated integrated chip
KR102019007B1 (en) * 2019-01-31 2019-09-05 제주대학교 산학협력단 Organs on a chip having intergrated sensors
US12600943B2 (en) 2019-02-01 2026-04-14 The University Of Hong Kong Innervated organoid compositions and methods of making same
US12497597B2 (en) 2019-05-31 2025-12-16 Children's Hospital Medical Center Methods of generating and expanding hematopoietic stem cells
AU2020283048A1 (en) 2019-05-31 2021-12-23 Children's Hospital Medical Center Shaped organoid compositions and methods of making same
KR102354778B1 (en) * 2019-09-30 2022-01-24 서울대학교병원 Microfluidic system mimicking lung tissue
WO2021071490A1 (en) * 2019-10-10 2021-04-15 Hewlett-Packard Development Company, L.P. Dispense cassettes for microfluidic dispensers
US12337312B2 (en) 2019-10-10 2025-06-24 Hewlett-Packard Development Company, L.P. Microfluidic dispensers for limiting dilution
CN110669670B (en) * 2019-11-14 2022-06-03 大连理工大学 Human body micro-ecosystem chip and use method thereof
KR102830487B1 (en) 2020-01-16 2025-07-08 삼성전자주식회사 Bio-electroceutical device using cell cluster
TWI728680B (en) 2020-02-04 2021-05-21 國立陽明交通大學 Biomimetic system
CN111304152B (en) * 2020-03-06 2024-07-05 上海市第十人民医院 A method for improving the microenvironment of in vitro 3D culture of organoids using femtosecond laser
CN111363682A (en) * 2020-04-22 2020-07-03 苏州济研生物医药科技有限公司 Organ chip with multilayer combined structure and use method thereof
CN116490882A (en) * 2020-09-24 2023-07-25 库瑞科技有限公司 AI laminated chip clinical prediction engine
CN112280678B (en) * 2020-12-25 2021-04-06 苏州大学 Detachable and reusable hydrophobic or super-hydrophobic microfluidic organ chip
EP4298201B1 (en) 2021-02-26 2025-04-30 Universidade do Minho Multiorgan-on-a-chip device with integrated microbiosensors, methods and uses thereof
WO2022265352A1 (en) * 2021-06-15 2022-12-22 연세대학교 산학협력단 Multi-organ model
CN114045218A (en) * 2021-10-21 2022-02-15 中国科学院大连化学物理研究所 Heart/liver/placenta/brain/pancreatic island multi-organ chip
CN115349517A (en) * 2022-09-14 2022-11-18 曹毓琳 Multiple micro-organ extracorporeal circulation and neural network maintenance system
CN115404165A (en) * 2022-09-30 2022-11-29 曹毓琳 Micro-organ specific maintenance system
CN115558601B (en) * 2022-11-30 2023-06-06 苏州大学 A miniature mammalian model and its application
DE102023202722A1 (en) * 2023-03-27 2024-10-02 Robert Bosch Gesellschaft Für Medizinische Forschung Mbh Microfluidic device for culturing a tissue section
WO2025040692A1 (en) 2023-08-22 2025-02-27 Fluosphera Sa Color- and position-based identification of multicellular structures for the multiplexed and individualized analysis of multi-tissue co-cultures
CN118853408B (en) * 2024-09-25 2024-12-10 南方科技大学 Heart organ chip and its preparation method

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4260627B2 (en) * 2001-04-25 2009-04-30 コーネル リサーチ ファンデイション インコーポレイテッド Device and method for cell culture system based on pharmacokinetics
JP2003210157A (en) * 2002-01-17 2003-07-29 Foundation For The Promotion Of Industrial Science Perfusion-type composite cell culture device, simulator including the device, and method for evaluating influence of chemical substance on living body using the device
CA2579680A1 (en) * 2004-09-16 2006-03-30 Becton, Dickinson And Company Perfusion bioreactor for culturing cells
RU45733U1 (en) * 2004-11-23 2005-05-27 Давыдов Владимир Николаевич INSTALLATION FOR IMPLEMENTATION OF MICROBIOLOGICAL PROCESSES
DE102006031871B4 (en) * 2006-07-10 2008-10-23 Gerlach, Jörg, Dr.med. 3-D Petri dish for breeding and examination of cells
WO2008024855A1 (en) * 2006-08-23 2008-02-28 Tautheta Instruments Llc Metabolic monitoring device
WO2009146911A2 (en) * 2008-06-04 2009-12-10 Uwe Marx Organ-on-a-chip-device
WO2009152618A1 (en) * 2008-06-17 2009-12-23 The Governing Council Of The University Of Toronto Device for investigation of a flow conduit
US8748180B2 (en) * 2009-07-29 2014-06-10 Cornell University Microfluidic device for pharmacokinetic-pharmacodynamic study of drugs and uses thereof
CA2807438C (en) 2010-08-06 2020-09-01 Technische Universitaet Berlin Self-contained circulation system and method of use thereof

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