SG11201501790VA - Multi-organ-chip with improved life time and homoeostasis - Google Patents
Multi-organ-chip with improved life time and homoeostasisInfo
- Publication number
- SG11201501790VA SG11201501790VA SG11201501790VA SG11201501790VA SG11201501790VA SG 11201501790V A SG11201501790V A SG 11201501790VA SG 11201501790V A SG11201501790V A SG 11201501790VA SG 11201501790V A SG11201501790V A SG 11201501790VA SG 11201501790V A SG11201501790V A SG 11201501790VA
- Authority
- SG
- Singapore
- Prior art keywords
- homoeostasis
- organ
- chip
- life time
- improved life
- Prior art date
Links
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5082—Supracellular entities, e.g. tissue, organisms
- G01N33/5088—Supracellular entities, e.g. tissue, organisms of vertebrates
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502746—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means for controlling flow resistance, e.g. flow controllers, baffles or throttle valves
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads or physically stretching molecules
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M21/00—Bioreactors or fermenters specially adapted for specific uses
- C12M21/08—Bioreactors or fermenters specially adapted for specific uses for producing artificial tissue or for ex-vivo cultivation of tissue
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/02—Form or structure of the vessel
- C12M23/04—Flat or tray type, drawers
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/02—Form or structure of the vessel
- C12M23/16—Microfluidic devices; Capillary tubes
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/22—Transparent or translucent parts
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/24—Gas permeable parts
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/34—Internal compartments or partitions
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/40—Manifolds; Distribution pieces
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/48—Holding appliances; Racks; Supports
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/26—Means for regulation, monitoring, measurement or control, e.g. flow regulation of pH
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/40—Means for regulation, monitoring, measurement or control, e.g. flow regulation of pressure
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/46—Means for regulation, monitoring, measurement or control, e.g. flow regulation of cellular or enzymatic activity or functionality, e.g. cell viability
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0809—Geometry, shape and general structure rectangular shaped
- B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
- B01L2400/0481—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure squeezing of channels or chambers
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/06—Valves, specific forms thereof
- B01L2400/0633—Valves, specific forms thereof with moving parts
- B01L2400/0655—Valves, specific forms thereof with moving parts pinch valves
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/08—Regulating or influencing the flow resistance
- B01L2400/082—Active control of flow resistance, e.g. flow controllers
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M27/00—Means for mixing, agitating or circulating fluids in the vessel
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Sustainable Development (AREA)
- General Engineering & Computer Science (AREA)
- Clinical Laboratory Science (AREA)
- Analytical Chemistry (AREA)
- Hematology (AREA)
- Dispersion Chemistry (AREA)
- Molecular Biology (AREA)
- Cell Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Physics & Mathematics (AREA)
- Urology & Nephrology (AREA)
- Fluid Mechanics (AREA)
- Food Science & Technology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Medicinal Chemistry (AREA)
- Tropical Medicine & Parasitology (AREA)
- Toxicology (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Prostheses (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261706928P | 2012-09-28 | 2012-09-28 | |
| EP12186550.5A EP2712918B1 (en) | 2012-09-28 | 2012-09-28 | Multi-organ-chip with improved life time and homoeostasis |
| PCT/EP2013/067073 WO2014048637A1 (en) | 2012-09-28 | 2013-08-15 | Multi-organ-chip with improved life time and homoeostasis |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201501790VA true SG11201501790VA (en) | 2015-04-29 |
Family
ID=47010306
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201501790VA SG11201501790VA (en) | 2012-09-28 | 2013-08-15 | Multi-organ-chip with improved life time and homoeostasis |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US9791433B2 (en) |
| EP (2) | EP2712918B1 (en) |
| JP (1) | JP6129973B2 (en) |
| KR (1) | KR102067311B1 (en) |
| CN (1) | CN104685048B (en) |
| AU (1) | AU2013323042B2 (en) |
| BR (1) | BR112015006859B1 (en) |
| CA (1) | CA2885375C (en) |
| DK (1) | DK2712918T3 (en) |
| ES (1) | ES2529994T3 (en) |
| IL (1) | IL237969A0 (en) |
| IN (1) | IN2015DN02765A (en) |
| PT (1) | PT2712918E (en) |
| RU (1) | RU2630667C2 (en) |
| SG (1) | SG11201501790VA (en) |
| WO (1) | WO2014048637A1 (en) |
Families Citing this family (60)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9719068B2 (en) | 2010-05-06 | 2017-08-01 | Children's Hospital Medical Center | Methods and systems for converting precursor cells into intestinal tissues through directed differentiation |
| US10023832B2 (en) | 2013-07-16 | 2018-07-17 | Vanderbilt University | Interconnections of multiple perfused engineered tissue constructs and microbioreactors, multi-microformulators and applications of the same |
| SG10201801654RA (en) | 2014-05-28 | 2018-04-27 | Childrens Hospital Med Ct | Methods and systems for converting precursor cells into gastric tissues through directed differentiation |
| JP6439115B2 (en) * | 2014-06-10 | 2018-12-19 | 一般財団法人生産技術研究奨励会 | How to develop and maintain the function of tissue fragments |
| AU2015331848B2 (en) | 2014-10-17 | 2022-03-03 | Children's Hospital Medical Center, D/B/A Cincinnati Children's Hospital Medical Center | In vivo model of human small intestine using pluripotent stem cells and methods of making and using same |
| RU2584598C1 (en) * | 2015-03-27 | 2016-05-20 | Общество с ограниченной ответственностью Научно-технический центр "БиоКлиникум" | Microfluid chip for creation of mammalian organ cell models |
| CN104826676B (en) * | 2015-05-04 | 2016-08-24 | 清华大学深圳研究生院 | Micro-fluidic chip, system and application thereof |
| EP3415611B1 (en) * | 2016-01-07 | 2025-05-14 | Vanderbilt University | Multi-microformulators and applications of the same |
| WO2017123855A1 (en) * | 2016-01-13 | 2017-07-20 | President And Fellows Of Harvard College | Microfluidic sample devices and uses thereof |
| RU171690U1 (en) * | 2016-03-24 | 2017-06-09 | Общество с ограниченной ответственностью Научно-технический центр "БиоКлиникум" | Microfluidic Chip for the Creation of Cellular Models of Mammalian Organs |
| CN109415685B (en) | 2016-05-05 | 2023-07-04 | 儿童医院医疗中心 | Method for producing gastric fundus tissue in vitro and compositions related thereto |
| US11078898B2 (en) * | 2016-05-24 | 2021-08-03 | Somavac Medical Solutions, Inc. | Portable device with disposable reservoir for collection of internal fluid after surgery |
| EP4253956A3 (en) * | 2016-10-14 | 2023-12-06 | Wake Forest University Health Sciences | Multi-organ "body on a chip" apparatus utilizing a common media |
| EP4553082A3 (en) | 2016-11-04 | 2025-08-20 | Children's Hospital Medical Center | Liver organoid compositions and methods of making and using same |
| JP7583524B2 (en) * | 2016-11-23 | 2024-11-14 | モルフォセル テクノロジーズ インコーポレイテッド | Encapsulated liver tissue |
| KR102492455B1 (en) | 2016-11-24 | 2023-01-27 | 알베오릭스 테크놀러지스 아게 | Cell culture systems and methods |
| EP3548507A4 (en) | 2016-12-05 | 2020-07-15 | Children's Hospital Medical Center | COLON ORGANOIDS AND METHOD FOR THE PRODUCTION AND USE THEREOF |
| KR101970125B1 (en) | 2017-01-16 | 2019-04-18 | 한림대학교 산학협력단 | Stretchable skin-on-a-chips |
| JP7265988B2 (en) * | 2017-02-03 | 2023-04-27 | コーネル ユニヴァーシティー | Stable three-dimensional blood vessel and method for forming same |
| CN106859716B (en) * | 2017-03-02 | 2023-03-14 | 福建医科大学附属协和医院 | Pancreas intestines anastomat |
| JP7248586B2 (en) | 2017-04-14 | 2023-03-29 | チルドレンズ ホスピタル メディカル センター | Multi-Donor Stem Cell Compositions and Methods of Making Them |
| CN110997024A (en) * | 2017-06-09 | 2020-04-10 | 哈佛大学的校长及成员们 | Methods of enhancing renal organoid development and methods of using the same |
| CN107312711B (en) * | 2017-06-26 | 2020-02-07 | 清华大学深圳研究生院 | Self-circulation tissue/organ chip device and manufacturing method thereof |
| EP3694603B1 (en) | 2017-10-10 | 2026-04-08 | Children's Hospital Medical Center | Esophageal tissue and/or organoid compositions and methods of making same |
| SG11202003790PA (en) * | 2017-10-31 | 2020-05-28 | Murdoch Childrens Res Inst | Composition and method |
| EP3727394A4 (en) | 2017-12-21 | 2021-09-08 | Children's Hospital Medical Center | DIGITIZED HUMAN ORGANOIDS AND METHODS OF USING THEM |
| US12038432B2 (en) | 2018-02-02 | 2024-07-16 | Wake Forest University Health Sciences | Organoids related to immunotherapy and methods of preparing and using the same |
| US11731126B2 (en) | 2018-04-19 | 2023-08-22 | Nanyang Technological University | Microfluidic board and method of forming the same |
| WO2019222871A1 (en) * | 2018-05-21 | 2019-11-28 | 深圳华大生命科学研究院 | Bionic intestinal-hepatic organ chip, preparation method therefor and application thereof |
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| CA3112026A1 (en) | 2018-09-12 | 2020-03-19 | Children's Hospital Medical Center | Organoid compositions for the production of hematopoietic stem cells and derivatives thereof |
| WO2020081740A1 (en) | 2018-10-17 | 2020-04-23 | Northwestern University | Tissue culture platform having multiple well chambers fluidically coupled via microfluidic channels and selector valves |
| CN109337813B (en) * | 2018-10-19 | 2023-07-11 | 杭州捷诺飞生物科技股份有限公司 | System and method suitable for biological tissue culture and real-time monitoring |
| WO2020087148A1 (en) * | 2018-11-02 | 2020-05-07 | Centro Nacional De Pesquisa Em Energia E Materiais – Cnpem | Platform for multi-systems culture, bioreactors and methods for in vitro experimental assays |
| CN111269830B (en) * | 2018-12-05 | 2022-07-15 | 中国科学院大连化学物理研究所 | Multi-organ chip based on microfluidic technology and application thereof |
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| US12600943B2 (en) | 2019-02-01 | 2026-04-14 | The University Of Hong Kong | Innervated organoid compositions and methods of making same |
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| KR102354778B1 (en) * | 2019-09-30 | 2022-01-24 | 서울대학교병원 | Microfluidic system mimicking lung tissue |
| WO2021071490A1 (en) * | 2019-10-10 | 2021-04-15 | Hewlett-Packard Development Company, L.P. | Dispense cassettes for microfluidic dispensers |
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| CN110669670B (en) * | 2019-11-14 | 2022-06-03 | 大连理工大学 | Human body micro-ecosystem chip and use method thereof |
| KR102830487B1 (en) | 2020-01-16 | 2025-07-08 | 삼성전자주식회사 | Bio-electroceutical device using cell cluster |
| TWI728680B (en) | 2020-02-04 | 2021-05-21 | 國立陽明交通大學 | Biomimetic system |
| CN111304152B (en) * | 2020-03-06 | 2024-07-05 | 上海市第十人民医院 | A method for improving the microenvironment of in vitro 3D culture of organoids using femtosecond laser |
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| CN116490882A (en) * | 2020-09-24 | 2023-07-25 | 库瑞科技有限公司 | AI laminated chip clinical prediction engine |
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| JP2003210157A (en) * | 2002-01-17 | 2003-07-29 | Foundation For The Promotion Of Industrial Science | Perfusion-type composite cell culture device, simulator including the device, and method for evaluating influence of chemical substance on living body using the device |
| CA2579680A1 (en) * | 2004-09-16 | 2006-03-30 | Becton, Dickinson And Company | Perfusion bioreactor for culturing cells |
| RU45733U1 (en) * | 2004-11-23 | 2005-05-27 | Давыдов Владимир Николаевич | INSTALLATION FOR IMPLEMENTATION OF MICROBIOLOGICAL PROCESSES |
| DE102006031871B4 (en) * | 2006-07-10 | 2008-10-23 | Gerlach, Jörg, Dr.med. | 3-D Petri dish for breeding and examination of cells |
| WO2008024855A1 (en) * | 2006-08-23 | 2008-02-28 | Tautheta Instruments Llc | Metabolic monitoring device |
| WO2009146911A2 (en) * | 2008-06-04 | 2009-12-10 | Uwe Marx | Organ-on-a-chip-device |
| WO2009152618A1 (en) * | 2008-06-17 | 2009-12-23 | The Governing Council Of The University Of Toronto | Device for investigation of a flow conduit |
| US8748180B2 (en) * | 2009-07-29 | 2014-06-10 | Cornell University | Microfluidic device for pharmacokinetic-pharmacodynamic study of drugs and uses thereof |
| CA2807438C (en) | 2010-08-06 | 2020-09-01 | Technische Universitaet Berlin | Self-contained circulation system and method of use thereof |
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