SG116574A1 - New process for the synthesis of 1,3,4,5-tetrahydro-2H-3-benzazepin-2-one compounds, and applicationin the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid. - Google Patents

New process for the synthesis of 1,3,4,5-tetrahydro-2H-3-benzazepin-2-one compounds, and applicationin the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid.

Info

Publication number: SG116574A1
Authority: SG; Singapore
Prior art keywords: synthesis; applicationin; ivabradine; benzazepin; tetrahydro
Prior art date: 2004-04-13

Application number

SG200500770A

Other languages

English (en)

Inventor

Lerestif Jean-Michel

Lecouve Jean-Pierre

Souvie Jean-Claude

Brigot Daniel

Original Assignee

Servier Lab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-04-13

Filing date

2005-02-15

Publication date

2005-11-28

2005-02-15 Application filed by Servier Lab filed Critical Servier Lab

2005-11-28 Publication of SG116574A1 publication Critical patent/SG116574A1/en

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/16—Benzazepines; Hydrogenated benzazepines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Cardiology (AREA)
Pharmacology & Pharmacy (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Heart & Thoracic Surgery (AREA)
Veterinary Medicine (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Hospice & Palliative Care (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Other In-Based Heterocyclic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

SG200500770A 2004-04-13 2005-02-15 New process for the synthesis of 1,3,4,5-tetrahydro-2H-3-benzazepin-2-one compounds, and applicationin the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid. SG116574A1 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR0403828A FR2868775B1 (fr)	2004-04-13	2004-04-13	Nouveau procede de synthese de derives de la 1,3,4,5- tetrahydro-2h-3-benzazepin-2-one, et application a la synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable

Publications (1)

Publication Number	Publication Date
SG116574A1 true SG116574A1 (en)	2005-11-28

Family

ID=34941961

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SG200500770A SG116574A1 (en)	2004-04-13	2005-02-15	New process for the synthesis of 1,3,4,5-tetrahydro-2H-3-benzazepin-2-one compounds, and applicationin the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid.

Country Status (32)

Country	Link
US (1)	US7064200B2 (sr)
EP (1)	EP1614687B1 (sr)
JP (2)	JP4515933B2 (sr)
KR (1)	KR100636499B1 (sr)
CN (1)	CN100348585C (sr)
AR (1)	AR047707A1 (sr)
AT (1)	ATE448221T1 (sr)
AU (1)	AU2005200884B2 (sr)
BR (1)	BRPI0500590B8 (sr)
CA (1)	CA2496712C (sr)
CY (1)	CY1109740T1 (sr)
DE (1)	DE602005017541D1 (sr)
DK (1)	DK1614687T3 (sr)
EA (1)	EA007743B1 (sr)
EG (1)	EG25619A (sr)
ES (1)	ES2336461T3 (sr)
FR (1)	FR2868775B1 (sr)
GE (1)	GEP20074136B (sr)
HR (1)	HRP20100024T1 (sr)
MA (1)	MA27598A1 (sr)
MX (1)	MXPA05003696A (sr)
MY (1)	MY140904A (sr)
NO (1)	NO329861B1 (sr)
NZ (1)	NZ538328A (sr)
PL (1)	PL1614687T3 (sr)
PT (1)	PT1614687E (sr)
RS (1)	RS51232B (sr)
SG (1)	SG116574A1 (sr)
SI (1)	SI1614687T1 (sr)
UA (1)	UA81773C2 (sr)
WO (1)	WO2005111027A1 (sr)
ZA (1)	ZA200501468B (sr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2868777B1 (fr) *	2004-04-13	2006-05-26	Servier Lab	Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
FR2868775B1 (fr) *	2004-04-13	2008-04-11	Servier Lab	Nouveau procede de synthese de derives de la 1,3,4,5- tetrahydro-2h-3-benzazepin-2-one, et application a la synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
GT200500185A (es) *	2004-08-09	2006-04-10		Moduladores del receptor de progesterona que comprenden derivados de pirrol-oxindol y sus usos
PT2471780E (pt)	2007-05-30	2015-02-24	Ind Swift Lab Ltd	Sais oxalato de ivabradina cristalinos e seus polimorfos
ES2402765T3 (es)	2008-12-22	2013-05-08	Krka, D.D., Novo Mesto	Procedimiento de preparación de ivabradina
FR2940287B1 (fr) *	2008-12-24	2010-12-24	Servier Lab	Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable.
EP2534135A2 (en)	2010-02-12	2012-12-19	KRKA, D.D., Novo Mesto	Novel forms of ivabradine hydrochloride
FR2956401B1 (fr) *	2010-02-17	2012-02-03	Servier Lab	Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
FR2971507B1 (fr) *	2011-02-14	2013-01-18	Servier Lab	Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
FR2984320B1 (fr) *	2011-12-20	2013-11-29	Servier Lab	Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
FR2993561B1 (fr) *	2012-07-17	2014-10-31	Servier Lab	Procede de synthese enzymatique de la (7s)-1-(3,4-dimethoxy bicyclo[4.2.0]octa-1,3,5-triene 7-yl) n-methyl methanamine, et application a la synthese de l'ivabradine et de ses sels
FR3003859B1 (fr) *	2013-03-26	2015-03-13	Servier Lab	"procede de synthese de derives de la 7,8-dimethoxy-1,3-dihydro-2h-3-benzazepin-2-one et application a la synthese de l'ivabradine"

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3119874A1 (de) *	1981-05-19	1982-12-09	Dr. Karl Thomae Gmbh, 7950 Biberach	"benzazepinderivate, ihre herstellung und ihre verwendung als arzneimittel"
DE3418270A1 (de) *	1984-05-17	1985-11-21	Dr. Karl Thomae Gmbh, 7950 Biberach	Neue aminotetralinderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
EP0204349A3 (de) *	1985-06-01	1990-01-03	Dr. Karl Thomae GmbH	Neue heteroaromatische Aminderivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
DE3519735A1 (de) *	1985-06-01	1986-12-04	Dr. Karl Thomae Gmbh, 7950 Biberach	Neue heteroaromatische aminderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
FR2681862B1 (fr) *	1991-09-27	1993-11-12	Adir Cie	Nouvelles (benzocycloalkyl)alkylamines, leur procede de preparation, et les compositions pharmaceutiques qui les contiennent.
FR2868777B1 (fr) *	2004-04-13	2006-05-26	Servier Lab	Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
FR2868775B1 (fr) *	2004-04-13	2008-04-11	Servier Lab	Nouveau procede de synthese de derives de la 1,3,4,5- tetrahydro-2h-3-benzazepin-2-one, et application a la synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable

2004
- 2004-04-13 FR FR0403828A patent/FR2868775B1/fr not_active Expired - Fee Related
2005
- 2005-02-07 CA CA2496712A patent/CA2496712C/fr not_active Expired - Lifetime
- 2005-02-15 SG SG200500770A patent/SG116574A1/en unknown
- 2005-02-17 US US11/060,043 patent/US7064200B2/en not_active Expired - Lifetime
- 2005-02-18 NZ NZ538328A patent/NZ538328A/en not_active IP Right Cessation
- 2005-02-18 BR BRPI0500590A patent/BRPI0500590B8/pt not_active IP Right Cessation
- 2005-02-18 MY MYPI20050621A patent/MY140904A/en unknown
- 2005-02-18 AU AU2005200884A patent/AU2005200884B2/en not_active Expired
- 2005-02-18 JP JP2005041810A patent/JP4515933B2/ja not_active Expired - Lifetime
- 2005-02-18 CN CNB2005100542167A patent/CN100348585C/zh not_active Expired - Lifetime
- 2005-02-18 NO NO20050888A patent/NO329861B1/no unknown
- 2005-02-18 MA MA28112A patent/MA27598A1/fr unknown
- 2005-02-18 ZA ZA2005/01468A patent/ZA200501468B/en unknown
- 2005-02-18 AR ARP050100586A patent/AR047707A1/es active IP Right Grant
- 2005-02-18 GE GEAP8647A patent/GEP20074136B/en unknown
- 2005-02-18 UA UAA200501524A patent/UA81773C2/uk unknown
- 2005-02-19 EG EG2005020086A patent/EG25619A/xx active
- 2005-02-19 KR KR1020050013860A patent/KR100636499B1/ko not_active Expired - Lifetime
- 2005-02-21 SI SI200530864T patent/SI1614687T1/sl unknown
- 2005-02-21 DE DE602005017541T patent/DE602005017541D1/de not_active Expired - Lifetime
- 2005-02-21 ES ES05290383T patent/ES2336461T3/es not_active Expired - Lifetime
- 2005-02-21 EA EA200500240A patent/EA007743B1/ru unknown
- 2005-02-21 AT AT05290383T patent/ATE448221T1/de active
- 2005-02-21 PT PT05290383T patent/PT1614687E/pt unknown
- 2005-02-21 PL PL05290383T patent/PL1614687T3/pl unknown
- 2005-02-21 DK DK05290383.8T patent/DK1614687T3/da active
- 2005-02-21 EP EP05290383A patent/EP1614687B1/fr not_active Expired - Lifetime
- 2005-02-21 WO PCT/FR2005/000396 patent/WO2005111027A1/fr not_active Ceased
- 2005-02-21 RS RSP-2010/0006A patent/RS51232B/sr unknown
- 2005-04-07 MX MXPA05003696A patent/MXPA05003696A/es active IP Right Grant
2009
- 2009-09-25 JP JP2009220529A patent/JP5277130B2/ja not_active Expired - Lifetime
2010
- 2010-01-13 HR HR20100024T patent/HRP20100024T1/hr unknown
- 2010-01-19 CY CY20101100053T patent/CY1109740T1/el unknown

Also Published As

Publication number	Publication date
AR047707A1 (es)	2006-02-08
MA27598A1 (fr)	2005-11-01
KR100636499B1 (ko)	2006-10-18
JP5277130B2 (ja)	2013-08-28
JP4515933B2 (ja)	2010-08-04
ES2336461T3 (es)	2010-04-13
WO2005111027A1 (fr)	2005-11-24
BRPI0500590B1 (pt)	2018-10-09
US7064200B2 (en)	2006-06-20
GEP20074136B (en)	2007-06-25
EA007743B1 (ru)	2006-12-29
AU2005200884A1 (en)	2005-10-27
NO329861B1 (no)	2011-01-17
CN100348585C (zh)	2007-11-14
MY140904A (en)	2010-01-29
EP1614687B1 (fr)	2009-11-11
CY1109740T1 (el)	2014-09-10
ZA200501468B (en)	2005-11-30
ATE448221T1 (de)	2009-11-15
NO20050888L (no)	2005-10-14
BRPI0500590A (pt)	2005-11-16
AU2005200884B2 (en)	2010-07-15
RS51232B (sr)	2010-12-31
NZ538328A (en)	2005-10-28
KR20060042117A (ko)	2006-05-12
NO20050888D0 (no)	2005-02-18
PT1614687E (pt)	2009-12-02
JP2010047577A (ja)	2010-03-04
EG25619A (en)	2012-03-26
BRPI0500590B8 (pt)	2021-05-25
FR2868775A1 (fr)	2005-10-14
FR2868775B1 (fr)	2008-04-11
HK1079777A1 (zh)	2006-04-13
MXPA05003696A (es)	2006-01-24
CA2496712C (fr)	2010-04-06
CN1683343A (zh)	2005-10-19
DE602005017541D1 (de)	2009-12-24
CA2496712A1 (fr)	2005-10-13
SI1614687T1 (sl)	2010-01-29
DK1614687T3 (da)	2010-03-29
EA200500240A1 (ru)	2005-10-27
HRP20100024T1 (hr)	2010-02-28
US20050228178A1 (en)	2005-10-13
UA81773C2 (uk)	2008-02-11
JP2005298478A (ja)	2005-10-27
PL1614687T3 (pl)	2010-04-30
EP1614687A1 (fr)	2006-01-11

Publication	Publication Date	Title
AP2005003222A0 (en)	2005-03-31	New process for the synthesis of ivabradine and additional salts thereof with a pharmaceutically acceptable acid.
ZA200501469B (en)	2005-11-30	Process for the synthesis of (1s)-4,5-dimethoxy-1-(methylaminomethyl)-benzocyclobutane and addition salts thereof, and application in the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid
IL175860A0 (en)	2006-10-05	Method for the production of a solid, orally applicable pharmaceutical composition
HUS1400005I1 (hu)	2017-08-28	Kinazolinszármazékok, elõállításuk, alkalmazásuk és ezeket tartalmazó gyógyszerek
HUP0303699A3 (en)	2006-02-28	Substituted cinnamic acid guanidides, method for the production thereof, their use as a medicament, and a medicament containing these compounds
HUE037069T2 (hu)	2018-08-28	Eljárás nagy tisztaságú 2,4'-metiléndifenildiizocianát elõállítására
TWI345975B (en)	2011-08-01	Crystalline micronisate, process for the manufacture thereof and use thereof for the preparation of a medicament
SG116574A1 (en)	2005-11-28	New process for the synthesis of 1,3,4,5-tetrahydro-2H-3-benzazepin-2-one compounds, and applicationin the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid.
SG158026A1 (en)	2010-01-29	New process for the synthesis of 7,8-dimethoxy-1,3-dihydro-2h-3-benzazepin-2- one, and application in the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid
ZA200501467B (en)	2005-11-30	Process for the synthesis of 1,3-dihydro-2h-3-benzazepin-2-one compounds, and application in the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid
AU2002325614A1 (en)	2003-03-03	Compounds containing lactic acid elements, method for the production and use thereof as pharmaceutically active substances
WO2008099091A3 (fr)	2008-10-02	Utilisation de l'ivabradine pour l'obtention de medicaments destines au traitement de la dysfonction endotheliale
WO2007007182A3 (en)	2007-08-23	Solid and liquid dosage forms of an antiepileptic agent
IL162562A0 (en)	2005-11-20	Substituted imidazolidines, method for the production thereof, use thereof as a drug or for diagnosis, and drug containing substituted imidazolid
JO2518B1 (en)	2010-03-17	A new method for the combination of ivabradine and its added salts with pharmaceutically acceptable acid
AU2002339579A1 (en)	2004-05-13	A process for the preparation of 3,4,5-trifluoronitrobenzene
SG117528A1 (en)	2005-12-29	New process for the synthesis of (1S)-4,5-dimethoxy-1-(methylaminomethyl)-benzocyclobutane and addition salts thereof, and application in the synthesis of ivabradine and addition salts thereof, with