ZA884925B - Azithromycin dihydrate - Google Patents

Azithromycin dihydrate

Info

Publication number: ZA884925B
Authority: ZA; South Africa
Prior art keywords: azithromycin dihydrate; azithromycin; dihydrate
Prior art date: 1987-07-09

Application number

ZA884925A

Other languages

English (en)

Inventor

Douglas John Meldrum Allen

John Meldrum Allen Douglas

Kevin Michael Nepveux

Michael Nepveux Kevin

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-07-09

Filing date

1988-07-08

Publication date

1990-02-28

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22202456&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ZA884925(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1988-07-08 Application filed by Pfizer filed Critical Pfizer

1990-02-28 Publication of ZA884925B publication Critical patent/ZA884925B/xx

Links

VQEMDSRIOVZAOM-UHFFFAOYSA-N 4-(4-methylsulfonylphenyl)-1,3-thiazol-2-amine Chemical compound C1=CC(S(=O)(=O)C)=CC=C1C1=CSC(N)=N1 VQEMDSRIOVZAOM-UHFFFAOYSA-N 0.000 title 1
229960004924 azithromycin dihydrate Drugs 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
- C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Cardiology (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biotechnology (AREA)
Heart & Thoracic Surgery (AREA)
Pulmonology (AREA)
Oncology (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Immunology (AREA)
Communicable Diseases (AREA)
Vascular Medicine (AREA)
Urology & Nephrology (AREA)
Saccharide Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

ZA884925A 1987-07-09 1988-07-08 Azithromycin dihydrate ZA884925B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
PCT/US1987/001612 WO1989000576A1 (en)	1987-07-09	1987-07-09	Azithromycin dihydrate

Publications (1)

Publication Number	Publication Date
ZA884925B true ZA884925B (en)	1990-02-28

Family

ID=22202456

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA884925A ZA884925B (en)	1987-07-09	1988-07-08	Azithromycin dihydrate

Country Status (45)

Country	Link
US (1)	US6268489B1 (sr)
EP (1)	EP0298650B1 (sr)
JP (1)	JPH0631300B2 (sr)
KR (1)	KR900006218B1 (sr)
CN (1)	CN1016785B (sr)
AP (1)	AP44A (sr)
AR (1)	AR243532A1 (sr)
AT (1)	ATE72446T1 (sr)
AU (1)	AU604553B2 (sr)
BA (1)	BA98213B1 (sr)
BG (1)	BG47348A3 (sr)
CA (1)	CA1314876C (sr)
CS (1)	CS272241B2 (sr)
CY (1)	CY1776A (sr)
DD (1)	DD271705A5 (sr)
DE (1)	DE3868296D1 (sr)
DK (1)	DK172573B1 (sr)
EG (1)	EG18527A (sr)
ES (1)	ES2038756T3 (sr)
FI (1)	FI91263C (sr)
GR (1)	GR3003737T3 (sr)
HK (1)	HK127594A (sr)
HU (1)	HU211862A9 (sr)
IE (1)	IE60354B1 (sr)
IL (1)	IL86979A (sr)
IN (1)	IN168879B (sr)
IS (1)	IS1540B (sr)
LV (1)	LV10624B (sr)
MA (1)	MA21323A1 (sr)
MX (1)	MX12213A (sr)
MY (1)	MY103744A (sr)
NO (1)	NO171556C (sr)
NZ (1)	NZ225338A (sr)
OA (1)	OA08743A (sr)
PH (1)	PH30953A (sr)
PL (1)	PL157145B1 (sr)
PT (1)	PT87933B (sr)
RO (1)	RO107257B1 (sr)
RU (1)	RU2066324C1 (sr)
SG (1)	SG27794G (sr)
SI (1)	SI8811325A8 (sr)
UA (1)	UA27040C2 (sr)
WO (1)	WO1989000576A1 (sr)
YU (1)	YU45075B (sr)
ZA (1)	ZA884925B (sr)

Families Citing this family (78)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
HRP20020231A2 (en) *	2002-03-18	2003-12-31	Pliva D D	ISOSTRUCTURAL PSEUDOPOLYMORPHS OF 9-DEOXO-9a-AZA-9a-METHYL-9a-HOMOERYTHROMYCIN A
US5912331A (en) *	1991-03-15	1999-06-15	Merck & Co., Inc.	Process for the preparation of 9-deoxo-9(Z)-hydroxyiminoerythromycin A
US5985844A (en) *	1992-03-26	1999-11-16	Merck & Co., Inc.	Homoerythromycin A derivatives modified at the 4"-and 8A-positions
US5189159A (en) *	1992-04-02	1993-02-23	Merck & Co., Inc.	8a-AZA-8a-homoerythromycin cyclic iminoethers
EP0539223A1 (en) *	1991-10-25	1993-04-28	Ono Pharmaceutical Co., Ltd.	Glycine derivative monosodium salt tetrahydrate having an inhibitory effect on elastase
US5215980A (en) *	1992-01-17	1993-06-01	Merck & Co., Inc.	10-AZA-9-deoxo-11-deoxy-erythromycin A and derivatives thereof
US5210235A (en) *	1992-08-26	1993-05-11	Merck & Co., Inc.	Methods of elaborating erythromycin fragments into amine-containing fragments of azalide antibiotics
US5332807A (en) *	1993-04-14	1994-07-26	Merck & Co., Inc.	Process of producing 8A- and 9A-azalide antibiotics
CN1034734C (zh) *	1993-12-10	1997-04-30	北京市集才药物研究所	一种新的阿齐红霉素结晶及其制备方法
US5605889A (en)	1994-04-29	1997-02-25	Pfizer Inc.	Method of administering azithromycin
HUT77530A (hu) *	1994-05-06	1998-05-28	Pfizer Inc.	Azitromicint tartalmazó, szabályozott hatóanyag-felszabadítású dózisformák
ES2122905B1 (es) *	1996-07-11	1999-11-16	Astur Pharma Sa	Sintesis de 11,12-hidrogenoortoborato de 9-desoxo-9a-aza-11,12-desoxi-9a-metil-9a-homoeritromicina a. un procedimiento para la preparacion de 9-desoxo-9a-aza-9a-metil-9a-homoeritromicina a dihidrato (azitromicina dihidrato).
DK1036083T5 (da) *	1997-10-16	2005-04-04	Pliva Istrazivacki Inst D O O	Nye 9A-azalider
US6861411B1 (en)	1997-12-02	2005-03-01	Pfizer, Inc.	Method of treating eye infections with azithromycin
PT102130A (pt) *	1998-03-13	1999-09-30	Hovione Sociedade Quimica S A	Processo de preparacao de dihidrato de azitromicina
TW546302B (en) *	1998-05-08	2003-08-11	Biochemie Sa	Improvements in macrolide production
CA2245398C (en)	1998-08-21	2002-01-29	Apotex Inc.	Azithromycin monohydrate isopropanol clathrate and methods for the manufacture thereof
SI20639A (sl) *	1998-11-30	2002-02-28	Teva Pharmaceutical Industries Ltd.	Etanolat azitromicina, postopek za njegovo pripravo in njegovi farmacevtski sestavki
US7056893B2 (en)	1999-03-31	2006-06-06	Insite Vision, Inc.	Topical treatment for prevention of ocular infections
US6239113B1 (en)	1999-03-31	2001-05-29	Insite Vision, Incorporated	Topical treatment or prevention of ocular infections
DE60038610T2 (de) *	1999-05-18	2009-06-25	Pfizer Products Inc., Groton	Neue kristalline formen eines makrolidantibiotikums
AU5820400A (en) *	1999-06-29	2001-01-31	Biochemie S.A.	Macrolides
ES2177373B1 (es) *	1999-11-26	2003-11-01	Astur Pharma Sa	Preparacion de azitromicina en su forma no cristalina
EP1246831B1 (en) *	2000-01-04	2008-03-05	Teva Pharmaceutical Industries Ltd.	Preparation method of azithromycin dihydrate
ES2162764B1 (es) *	2000-05-17	2003-04-01	Ercros Ind Sa	Forma polimorfica del dihidrato de azitromicina, y su procedimiento deobtencion.
DE60026718T2 (de)	2000-07-25	2006-11-16	Laboratorio Silanes, S.A. De C.V.	Einstufiges verfahren zur herstellung von 7,16-deoxy-2-aza-10-o-cladinosil-12-o-desosaminil-4,5-dihydroxi-6-ethyl-3,5,9,11,13,15-hexamethylbicycle(11.2.11)hexadeca-1(2)-en-8-ona undeine neue form von 9-desoxo-9a-methyl-9a-aza-9a-homoerythromycin a
ES2172417B1 (es) *	2000-07-31	2003-09-16	Sint Quimica Sa	Nueva forma mejorada de azitromicina monohidrato de menor higroscopicidad, procedimiento de preparacion y composiciones farmaceuticas que la comprenden.
JP2004506664A (ja) *	2000-08-23	2004-03-04	ウォックハート・リミテッド	無水アジトロマイシンの製造法
CN100341886C (zh) *	2000-11-27	2007-10-10	桑多斯股份公司	大环内酯类化合物的溶剂化物
HRP20030430B1 (hr) *	2000-11-27	2011-11-30	Biochemie S.A.	Makrolidni solvati
IN190080B (sr) *	2001-01-29	2003-06-07	Alembic Ltd
KR100491183B1 (ko)	2001-03-21	2005-05-25	한미약품 주식회사	아지트로마이신의 제조방법 및 이 방법에 사용되는9-데옥소-9에이-아자-9에이-호모에리트로마이신 에이의결정성 수화물
ES2258142T3 (es) *	2001-05-22	2006-08-16	Pfizer Products Inc.	Nueva forma cristalina.
US6861413B2 (en)	2001-05-22	2005-03-01	Pfizer Inc.	Stable non-dihydrate azithromycin oral suspensions
SI1390377T1 (sl)	2001-05-22	2006-06-30	Pfizer Prod Inc	Nova kristalna oblika azitromicina
CA2458135A1 (en) *	2001-08-21	2003-03-06	Pfizer Products Inc.	Single dose azithromycin for treating respiratory infections
NZ532063A (en) *	2001-12-21	2006-03-31	Pfizer Prod Inc	Methods for wet granulating azithromycin
PL371259A1 (pl) *	2001-12-21	2005-06-13	Pfizer Products Inc.	Bezpośrednio sprasowywalne preparaty azytromycyny
RU2283092C2 (ru) *	2002-02-01	2006-09-10	Пфайзер Продактс Инк.	Сухие гранулированные композиции азитромицина
US7376064B2 (en)	2002-02-25	2008-05-20	Samsung Electronics Co., Ltd.	Method and apparatus for recording data on optical recording medium
ITMI20021209A1 (it) *	2002-06-04	2003-12-04	Chemi Spa	Processo di preparazione di azitromicina ad elevata purezza
US6855813B2 (en) *	2002-07-19	2005-02-15	Alembic Limited	Process for the preparation of azithromycin monohydrate
HRP20020614A2 (en)	2002-07-22	2004-06-30	PLIVA-ISTRAŽIVAČKI INSTITUT d.o.o.	Rhombic pseudopolymorph of 9-deoxo-9a-aza-9a-methyl-9a-homoerythromycin a
GB2395482A (en) *	2003-07-03	2004-05-26	Jubilant Organosys Ltd	Process for preparing non-hygroscopic azithromycin dihydrate
US20050013835A1 (en) *	2003-07-15	2005-01-20	Pfizer Inc.	Stable non-dihydrate azithromycin oral suspensions
KR100844628B1 (ko) *	2003-12-04	2008-07-07	화이자 프로덕츠 인크.	제약상 다입자의 제조 방법
MXPA06005913A (es) *	2003-12-04	2006-06-27	Pfizer Prod Inc	Formas de dosificacion de multiparticulas de azitromicina por procedimientos basados en liquidos.
EP1701702A1 (en) *	2003-12-04	2006-09-20	Pfizer Products Inc.	Spray-congeal process using an extruder for preparing multiparticulate azithromycin compositions containing preferably a poloxamer and a glyceride
ES2600577T3 (es) *	2003-12-04	2017-02-09	Bend Research, Inc.	Procedimiento de pulverización-solidificación que usa un extrusor para preparar composiciones en multipartículas de fármacos cristalinos
CA2547597A1 (en) *	2003-12-04	2005-06-16	Pfizer Products Inc.	Multiparticulate compositions with improved stability
US6984403B2 (en) *	2003-12-04	2006-01-10	Pfizer Inc.	Azithromycin dosage forms with reduced side effects
WO2005053652A1 (en)	2003-12-04	2005-06-16	Pfizer Products Inc.	Multiparticulate crystalline drug compositions containing a poloxamer and a glyceride
WO2005053639A2 (en) *	2003-12-04	2005-06-16	Pfizer Products Inc.	Controlled release multiparticulates formed with dissolution enhancers
RU2260012C1 (ru) *	2004-01-29	2005-09-10	Открытое акционерное общество "Акционерное курганское общество медицинских препаратов и изделий "Синтез"	Способ кристаллизации азитромицина дигидрата
US7468428B2 (en)	2004-03-17	2008-12-23	App Pharmaceuticals, Llc	Lyophilized azithromycin formulation
US20060116336A1 (en) *	2004-03-17	2006-06-01	American Pharmaceutical Partners, Inc.	Lyophilized azithromycin formulation
WO2006011160A1 (en)	2004-06-28	2006-02-02	Alembic Limited	Process for the preparation of azithromycin monohydrate isopropanol clathrate
CN1308361C (zh) *	2004-08-09	2007-04-04	大连振邦氟涂料股份有限公司	乙烯－三氟氯乙烯共聚物的制备方法
US7683162B2 (en) *	2004-08-30	2010-03-23	Taro Pharmaceutical Industries Limited	Process of preparing a crystalline azithromycin monohydrate
CA2584430A1 (en) *	2004-12-01	2006-06-08	Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag	Methods for preparing pimecrolimus
US20080199527A1 (en) *	2004-12-21	2008-08-21	Pfizer Inc.	Enteric Coated Azithromycin Multiparticulates
US8546423B2 (en)	2005-05-18	2013-10-01	Mpex Pharmaceuticals, Inc.	Aerosolized fluoroquinolones and uses thereof
CN100366686C (zh) *	2006-01-12	2008-02-06	济南瑞氟化工科技有限公司	一种氟硅超双疏不粘涂料
JP2009539866A (ja) *	2006-06-05	2009-11-19	オースペックス・ファーマシューティカルズ・インコーポレイテッド	置換エリスロマイシンアナログの調製および有用性
US7704959B2 (en)	2006-10-03	2010-04-27	Dow Pharmaceutical Sciences	Azithromycin for the treatment of nodular acne
US20090062220A1 (en) *	2007-08-29	2009-03-05	Protia, Llc	Deuterium-enriched azithromycin
CN101177441B (zh) *	2007-12-05	2012-05-23	浙江耐司康药业有限公司	一种稳定的阿奇霉素一水合物结晶的制备方法
CN101624412B (zh)	2008-07-10	2012-07-04	刘力	大环内酯类衍生物及其制备和用途
CA2739893C (en)	2008-10-07	2016-10-04	Mpex Pharmaceuticals, Inc.	Inhalation of levofloxacin for reducing lung inflammation
KR101959873B1 (ko)	2008-10-07	2019-03-19	랩터 파마슈티컬스 인코포레이티드	약동학 개선을 위한 에어로졸 플루오로퀴놀론 제형
CN101418026B (zh) *	2008-10-09	2011-05-18	南京工业大学	一种晶型和粒度可控的阿奇霉素结晶工艺
CN101787063B (zh) *	2009-01-23	2012-12-19	刘力	抗感染药物及其制备和用途
US20120058936A1 (en)	2009-03-13	2012-03-08	Assistance Publique - Hopitaux De Paris	Compositions and methods for elimination of gram negative bacteria
WO2011029059A1 (en)	2009-09-04	2011-03-10	Mpex Pharmaceuticals, Inc.	Use of aerosolized levofloxacin for treating cystic fibrosis
CN102911219A (zh) *	2011-08-03	2013-02-06	山东方明药业集团股份有限公司	一种阿齐霉素在水相直接结晶的方法
CN103159811A (zh) *	2011-12-10	2013-06-19	山东方明药业集团股份有限公司	一种阿齐霉素中间体9a-脱氧-9a-氮杂-9a-高红霉素A的制备方法
WO2013088274A1 (en)	2011-12-14	2013-06-20	Wockhardt Limited	Anhydrous amorphous azithromycin composition free of azithromycin dihydrate
CN102417531B (zh) *	2011-12-20	2014-06-11	浙江国邦药业有限公司	一种阿奇霉素一水合物的制备方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4020270A (en) *	1974-05-02	1977-04-26	Societa' Farmaceutici Italia S.P.A.	L-lyxohex-1-enopyranose derivative
US4219641A (en) *	1979-06-14	1980-08-26	The Upjohn Company	Process for preparing erythromycin succinate
SI8110592A8 (en)	1981-03-06	1996-06-30	Pliva Pharm & Chem Works	Process for preparing of n-methyl-11-aza-10-deoxo-10-dihydroerythromycine a and derivatives thereof
US4474768A (en) *	1982-07-19	1984-10-02	Pfizer Inc.	N-Methyl 11-aza-10-deoxo-10-dihydro-erytromycin A, intermediates therefor
US4526889A (en) *	1982-11-15	1985-07-02	Pfizer Inc.	Epimeric azahomoerythromycin A derivative, intermediates and method of use
PH19293A (en) *	1982-11-15	1986-03-04	Pfizer	Epimeric azahomoerythromycin,pharmaceutical composition containing the same and method of use thereof
US4512982A (en) *	1984-04-13	1985-04-23	Pfizer Inc.	9α-Aza-9α-homoerythromycin compounds, pharmaceutical composition and therapeutic method
YU43402B (en) *	1985-03-04	1989-06-30	Pliva Pharm & Chem Works	Process for preparation of 11-aza-10-deoxo-10-dihydroeritromycin "a" by using electro-chemical reduction
WO1989002271A1 (en)	1987-09-10	1989-03-23	Pfizer	Azithromycin and derivatives as antiprotozoal agents

1987
- 1987-07-09 WO PCT/US1987/001612 patent/WO1989000576A1/en not_active Ceased
- 1987-07-09 UA UA93004522A patent/UA27040C2/uk unknown
- 1987-07-09 RU SU874742955A patent/RU2066324C1/ru active
- 1987-07-09 RO RO143593A patent/RO107257B1/ro unknown
- 1987-07-09 MX MX1221388A patent/MX12213A/es unknown
1988
- 1988-05-11 IN IN418/DEL/88A patent/IN168879B/en unknown
- 1988-06-15 AP APAP/P/1988/000093A patent/AP44A/en active
- 1988-06-28 ES ES198888305921T patent/ES2038756T3/es not_active Expired - Lifetime
- 1988-06-28 EP EP88305921A patent/EP0298650B1/en not_active Expired - Lifetime
- 1988-06-28 DE DE8888305921T patent/DE3868296D1/de not_active Expired - Lifetime
- 1988-06-28 AT AT88305921T patent/ATE72446T1/de not_active IP Right Cessation
- 1988-07-04 IL IL86979A patent/IL86979A/xx not_active IP Right Cessation
- 1988-07-05 MY MYPI88000744A patent/MY103744A/en unknown
- 1988-07-05 BG BG084783A patent/BG47348A3/xx unknown
- 1988-07-06 JP JP63168637A patent/JPH0631300B2/ja not_active Expired - Lifetime
- 1988-07-06 CS CS884896A patent/CS272241B2/cs not_active IP Right Cessation
- 1988-07-07 PH PH37189A patent/PH30953A/en unknown
- 1988-07-07 PT PT87933A patent/PT87933B/pt not_active IP Right Cessation
- 1988-07-07 EG EG376/88A patent/EG18527A/xx active
- 1988-07-07 PL PL1988273590A patent/PL157145B1/pl unknown
- 1988-07-07 IS IS3370A patent/IS1540B/is unknown
- 1988-07-07 DD DD88317672A patent/DD271705A5/de unknown
- 1988-07-07 CA CA000571381A patent/CA1314876C/en not_active Expired - Lifetime
- 1988-07-07 AR AR88311356A patent/AR243532A1/es active
- 1988-07-08 IE IE210888A patent/IE60354B1/en not_active IP Right Cessation
- 1988-07-08 CN CN88104331A patent/CN1016785B/zh not_active Expired
- 1988-07-08 AU AU18839/88A patent/AU604553B2/en not_active Expired
- 1988-07-08 KR KR1019880008463A patent/KR900006218B1/ko not_active Expired
- 1988-07-08 YU YU1325/88A patent/YU45075B/xx unknown
- 1988-07-08 NZ NZ225338A patent/NZ225338A/xx unknown
- 1988-07-08 DK DK198803806A patent/DK172573B1/da not_active IP Right Cessation
- 1988-07-08 ZA ZA884925A patent/ZA884925B/xx unknown
- 1988-07-08 SI SI8811325A patent/SI8811325A8/sl unknown
- 1988-07-08 OA OA59384A patent/OA08743A/xx unknown
- 1988-07-11 MA MA21565A patent/MA21323A1/fr unknown
1990
- 1990-01-08 NO NO90900077A patent/NO171556C/no not_active IP Right Cessation
- 1990-01-08 FI FI900087A patent/FI91263C/fi not_active IP Right Cessation
1992
- 1992-02-06 GR GR920400067T patent/GR3003737T3/el unknown
- 1992-12-21 US US07/994,040 patent/US6268489B1/en not_active Expired - Lifetime
1993
- 1993-11-17 LV LVP-93-1240A patent/LV10624B/xx unknown
1994
- 1994-02-22 SG SG27794A patent/SG27794G/en unknown
- 1994-11-17 HK HK127594A patent/HK127594A/en not_active IP Right Cessation
1995
- 1995-06-30 HU HU95P/P00738P patent/HU211862A9/hu unknown
- 1995-10-20 CY CY177695A patent/CY1776A/xx unknown
1998
- 1998-03-30 BA BA980213A patent/BA98213B1/bs active

Also Published As

Publication number	Publication date
BA98213B1 (bs)	1999-08-02
AR243532A1 (es)	1993-08-31
FI900087A0 (fi)	1990-01-08
WO1989000576A1 (en)	1989-01-26
CY1776A (en)	1995-10-20
DK172573B1 (da)	1999-01-25
DK380688A (da)	1989-01-10
ATE72446T1 (de)	1992-02-15
IN168879B (sr)	1991-06-29
PT87933A (pt)	1989-06-30
DE3868296D1 (de)	1992-03-19
NO171556B (no)	1992-12-21
DK380688D0 (da)	1988-07-08
BG47348A3 (bg)	1990-06-15
AP44A (en)	1989-07-27
US6268489B1 (en)	2001-07-31
NO171556C (no)	1993-03-31
NZ225338A (en)	1990-02-26
IS1540B (is)	1994-01-28
EP0298650A2 (en)	1989-01-11
IS3370A7 (is)	1989-01-10
PL157145B1 (en)	1992-04-30
CN1030422A (zh)	1989-01-18
NO900077L (no)	1990-01-08
PT87933B (pt)	1994-09-30
IL86979A0 (en)	1988-12-30
RO107257B1 (ro)	1993-10-30
JPH0631300B2 (ja)	1994-04-27
HU211862A9 (en)	1995-12-28
MX12213A (es)	1993-05-01
MA21323A1 (fr)	1989-04-01
JPS6438096A (en)	1989-02-08
IE882108L (en)	1989-01-09
YU45075B (en)	1991-08-31
AU1883988A (en)	1989-01-12
OA08743A (fr)	1989-03-31
CS272241B2 (en)	1991-01-15
PL273590A1 (en)	1989-03-20
GR3003737T3 (sr)	1993-03-16
FI91263C (fi)	1994-06-10
FI900087L (fi)	1990-01-08
SI8811325A8 (en)	1996-12-31
MY103744A (en)	1993-09-30
KR900006218B1 (ko)	1990-08-25
EP0298650A3 (en)	1989-11-08
EG18527A (en)	1993-10-30
FI91263B (fi)	1994-02-28
HK127594A (en)	1994-11-25
CN1016785B (zh)	1992-05-27
LV10624A (lv)	1995-04-20
UA27040C2 (uk)	2000-02-28
RU2066324C1 (ru)	1996-09-10
CS489688A2 (en)	1990-03-14
SG27794G (en)	1994-10-14
PH30953A (en)	1997-12-23
NO900077D0 (no)	1990-01-08
DD271705A5 (de)	1989-09-13
CA1314876C (en)	1993-03-23
IE60354B1 (en)	1994-06-29
EP0298650B1 (en)	1992-02-05
LV10624B (en)	1995-10-20
AP8800093A0 (en)	1988-05-01
AU604553B2 (en)	1990-12-20
IL86979A (en)	1992-11-15
YU132588A (en)	1990-02-28
KR890002137A (ko)	1989-04-08
ES2038756T3 (es)	1993-08-01

Publication	Publication Date	Title
AP8800093A0 (en)	1988-05-01	Azithromycin dihydrate
GB2211106B (en)	1991-07-03	Manipulating means
ZA886738B (en)	1989-08-30	Macrolide compounds
CS418287A1 (en)	1988-07-15	Kompozicia k priprave tepelnoizolacnych omietok
HRP920589B1 (en)	2000-12-31	Macrolide compounds
IE870625L (en)	1987-09-12	Macrolide compounds
CS241787A1 (en)	1988-03-15	Nastroj k odstranovani bezcu z prstencu prstencoveho dopradaciho nebo skaciho stroje
GB8719825D0 (en)	1987-09-30	Complex
GB8723468D0 (en)	1987-11-11	Complex
CS3587A1 (en)	1988-07-15	Zarizeni k tepelnemu zpracovani praskoveho materialu
CS108987A1 (en)	1988-07-15	Zarizeni k oddelovani balickovane sadby
CS446787A1 (en)	1988-05-16	Zarizeni k vyrobe zvukoizolacnich plechu
CS338187A1 (en)	1988-07-15	Zarizeni k zatezovacimu zavaleckovani naslapne plochy nalepovanych podlahovin
CS22687A1 (en)	1988-02-15	Pridavne zarizeni k prubeznemu cisteni steticek rotacnich kartacu
CS223987A1 (en)	1988-07-15	Zarizeni k regulaci teploty plniciho vzduchu pistoveho preplnovaneho motoru
CS481487A1 (en)	1988-06-15	Zarizeni k neprimemu mereni tvrdosti
CS185487A1 (en)	1988-04-15	Zapojeni koderu cyklickeho kodu k elektronice rizeni elektronoveho svazku elektronove optickeho pristroje
CS148187A1 (en)	1988-07-15	Zarizeni k regulaci prutoku chladiva
CS131187A1 (en)	1988-01-15	Zarizeni k nastaveni polarizace laseroveho paprsku
CS382987A1 (en)	1988-07-15	Zarizeni k davkovani pastovitych substratu
CS503887A1 (en)	1988-05-16	Zarizeni k primemu pricne rektifikovatelnemu ulozeni kolejnice
CS504887A1 (en)	1988-05-16	Zarizeni k pricne posunovatelnemu primemu ulozeni kolejnice
CS619487A1 (en)	1988-07-15	Zarizeni k registraci polohy jednoho nastroje vuci druhemu
CS76787A1 (en)	1988-01-15	Pomucka k urcovani orientovanych adhenznich charakteristik
CS780987A1 (en)	1988-06-15	Zarizeni k blokovani minimalni mezery mezi pracovnimi valci