AR057610A2 - Composiciones anestesicas de sevoflurano, metodo para su preparacion, metodos para inhibir su degradacion ante la presencia de un acido lewis y un proceso para preparar una composicion anestesica estable en un contenedor sellado - Google Patents
Composiciones anestesicas de sevoflurano, metodo para su preparacion, metodos para inhibir su degradacion ante la presencia de un acido lewis y un proceso para preparar una composicion anestesica estable en un contenedor selladoInfo
- Publication number
- AR057610A2 AR057610A2 ARP060105042A ARP060105042A AR057610A2 AR 057610 A2 AR057610 A2 AR 057610A2 AR P060105042 A ARP060105042 A AR P060105042A AR P060105042 A ARP060105042 A AR P060105042A AR 057610 A2 AR057610 A2 AR 057610A2
- Authority
- AR
- Argentina
- Prior art keywords
- lewis acid
- anesthetic
- fluorether
- inhibit
- preparation
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 8
- 239000002841 Lewis acid Substances 0.000 title abstract 6
- 150000007517 lewis acids Chemical class 0.000 title abstract 6
- 230000003444 anaesthetic effect Effects 0.000 title abstract 4
- 239000000203 mixture Substances 0.000 title abstract 4
- 230000015556 catabolic process Effects 0.000 title abstract 3
- 238000006731 degradation reaction Methods 0.000 title abstract 3
- DFEYYRMXOJXZRJ-UHFFFAOYSA-N sevoflurane Chemical compound FCOC(C(F)(F)F)C(F)(F)F DFEYYRMXOJXZRJ-UHFFFAOYSA-N 0.000 title abstract 2
- 229960002078 sevoflurane Drugs 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 5
- 239000003112 inhibitor Substances 0.000 abstract 3
- 230000000087 stabilizing effect Effects 0.000 abstract 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 3
- 238000004519 manufacturing process Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/075—Ethers or acetals
- A61K31/08—Ethers or acetals acyclic, e.g. paraformaldehyde
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Engineering & Computer Science (AREA)
- Inorganic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Anesthesiology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Catalysts (AREA)
- Steroid Compounds (AREA)
Abstract
Una composicion anestésica que comprende un compuesto de fluoréter que tiene una porcion de alfa fluoréter que se le agrego una cantidad estabilizante efectiva de un inhibidor de ácido Lewis excepto agua; un método para su preparacion, un método para estabilizar un compuesto de fluoréter anhidro que tiene una porcion de alfa fluoréter, el método comprende el paso de agregar al compuesto de fluoréter anhidro, una cantidad estabilizadora efectiva de un inhibidor de ácido Lewis excepto el agua al compuesto para impedir la degradacion del compuesto de fluoréter por medio del ácido Lewis, un método para inhibir la degradacion de un ácido de Lewis y un proceso para preparar una composicion anestésica estable en un contenedor sellado, caracterizado porque el proceso que comprende las etapas de: a) proveer un contenedor; b) adicionar un inhibidor de ácido de Lewis excepto el agua a dicho contenedor; c) adicionar una cantidad de sevoflurano al contenedor obtenido por la etapa b); y d) sellar dicho contenedor.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/789,679 US5990176A (en) | 1997-01-27 | 1997-01-27 | Fluoroether compositions and methods for inhibiting their degradation in the presence of a Lewis acid |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR057610A2 true AR057610A2 (es) | 2007-12-05 |
Family
ID=25148366
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP980100336A AR011090A1 (es) | 1997-01-27 | 1998-01-26 | COMPOSICIONES ANESTÉSICAS DE SEVOFLURANO, METODO PARA SU PREPARACIoN, MÉTODOS PARA INHIBIR SU DEGRADACIoN ANTE LA PRESENCIA DE UN ÁCIDO LEWIS Y UN PROCESO PARA PREPARAR UNA COMPOSICION ANESTÉSICA ESTABLE EN UN CONTENEDOR SELLADO |
| ARP060105042A AR057610A2 (es) | 1997-01-27 | 2006-11-16 | Composiciones anestesicas de sevoflurano, metodo para su preparacion, metodos para inhibir su degradacion ante la presencia de un acido lewis y un proceso para preparar una composicion anestesica estable en un contenedor sellado |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP980100336A AR011090A1 (es) | 1997-01-27 | 1998-01-26 | COMPOSICIONES ANESTÉSICAS DE SEVOFLURANO, METODO PARA SU PREPARACIoN, MÉTODOS PARA INHIBIR SU DEGRADACIoN ANTE LA PRESENCIA DE UN ÁCIDO LEWIS Y UN PROCESO PARA PREPARAR UNA COMPOSICION ANESTÉSICA ESTABLE EN UN CONTENEDOR SELLADO |
Country Status (27)
| Country | Link |
|---|---|
| US (6) | US5990176A (es) |
| EP (2) | EP1114641B1 (es) |
| JP (5) | JP3183520B2 (es) |
| KR (1) | KR100368672B1 (es) |
| CN (3) | CN1899271A (es) |
| AR (2) | AR011090A1 (es) |
| AT (2) | ATE320798T1 (es) |
| AU (1) | AU726733B2 (es) |
| BG (2) | BG65414B1 (es) |
| BR (1) | BR9806996A (es) |
| CA (2) | CA2278133C (es) |
| CO (1) | CO4920220A1 (es) |
| CZ (1) | CZ297092B6 (es) |
| DE (2) | DE69833884T2 (es) |
| DK (2) | DK1114641T3 (es) |
| ES (2) | ES2170474T3 (es) |
| GR (1) | GR3036190T3 (es) |
| HU (1) | HUP0002101A3 (es) |
| IL (1) | IL130150A (es) |
| NO (1) | NO993606L (es) |
| NZ (1) | NZ335994A (es) |
| PL (1) | PL334477A1 (es) |
| PT (2) | PT967975E (es) |
| SK (1) | SK284243B6 (es) |
| TR (1) | TR199901579T2 (es) |
| WO (1) | WO1998032430A1 (es) |
| ZA (1) | ZA98418B (es) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5990176A (en) * | 1997-01-27 | 1999-11-23 | Abbott Laboratories | Fluoroether compositions and methods for inhibiting their degradation in the presence of a Lewis acid |
| US6162443A (en) * | 1998-01-09 | 2000-12-19 | Abbott Laboratories | Container for an inhalation anesthetic |
| US6074668A (en) * | 1998-01-09 | 2000-06-13 | Abbott Laboratories | Container for an inhalation anesthetic |
| US20030200963A1 (en) * | 1998-01-09 | 2003-10-30 | Flament-Garcia Mary Jane | Container for an inhalation anesthetic |
| US6979456B1 (en) | 1998-04-01 | 2005-12-27 | Jagotec Ag | Anticancer compositions |
| DE69912441T2 (de) | 1998-08-19 | 2004-08-19 | Skyepharma Canada Inc., Verdun | Injizierbare wässerige propofoldispersionen |
| EP1018827B1 (en) | 1999-01-08 | 2004-05-06 | Sony International (Europe) GmbH | Synchronisation structure for OFDM system |
| TW523409B (en) | 2000-09-15 | 2003-03-11 | Baxter Int | Container for inhalation anesthetic |
| ATE365034T1 (de) * | 2003-09-10 | 2007-07-15 | Cristalia Prod Quimicos Farm | Stabile pharmazeutische zusammensetzung einer fluorether-verbindung für die anästhesie, verfahren zur stabilisierung einer fluorether- verbindung, verwendung eines stabilisierungsmittels zum ausschluss des abbaus einer fluorether-verbindung |
| BR0303489A (pt) * | 2003-09-10 | 2005-07-05 | Cristalia Prod Quimicos Farm | Composição farmacêutica estabilizada de composto flúor-éter e método para inibir a degradação de composto flúor-éter. uso de agente estabilizante para inibir a degradação de composto flúor éter |
| US20060258755A1 (en) * | 2005-04-18 | 2006-11-16 | Terrell Ross C | Preparation of sevoflurane with negligible water content |
| WO2009049460A1 (en) * | 2007-10-15 | 2009-04-23 | Jiangsu Hengrui Medicine Co., Ltd. | New packaging material for sevoflurane |
| PL2244737T3 (pl) * | 2008-01-22 | 2020-05-18 | The Board Of Regents Of The University Of Texas System | Kompozycje lotnego środka znieczulającego zawierające rozpuszczalniki ekstrakcyjne do znieczulania miejscowego i / albo zwalczania bólu |
| US20090275785A1 (en) | 2008-05-01 | 2009-11-05 | Barry Jones | Distillation Method For The Purification Of Sevoflurane And The Maintenance Of Certain Equipment That May Be Used In The Distillation Process |
| US8563115B2 (en) | 2008-08-12 | 2013-10-22 | Xerox Corporation | Protective coatings for solid inkjet applications |
| US8092822B2 (en) * | 2008-09-29 | 2012-01-10 | Abbott Cardiovascular Systems Inc. | Coatings including dexamethasone derivatives and analogs and olimus drugs |
| US8283643B2 (en) * | 2008-11-24 | 2012-10-09 | Cymer, Inc. | Systems and methods for drive laser beam delivery in an EUV light source |
| US8191992B2 (en) * | 2008-12-15 | 2012-06-05 | Xerox Corporation | Protective coatings for solid inkjet applications |
| US9278048B2 (en) * | 2009-05-06 | 2016-03-08 | Baxter International, Inc. | Pharmaceutical product and method of use |
| US9102604B1 (en) | 2010-02-15 | 2015-08-11 | Baxter International Inc. | Methods for cleaning distilling columns |
| CN105193774B (zh) * | 2015-09-21 | 2018-01-16 | 山东新时代药业有限公司 | 一种七氟烷吸入剂 |
| CN105106182B (zh) * | 2015-09-21 | 2017-12-29 | 山东新时代药业有限公司 | 七氟烷吸入剂 |
| CA2952552C (en) | 2016-11-02 | 2018-05-15 | Central Glass Company, Limited | Method for washing sevoflurane storage container and method for storing sevoflurane |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2992276A (en) * | 1959-05-20 | 1961-07-11 | Du Pont | Process for preparing polyfluoro alkyl compounds |
| US3527813A (en) * | 1966-10-03 | 1970-09-08 | Air Reduction | 1,1,2 - trifluoro - 2 - chloroethyl difluoromethyl ether and its method of preparation |
| US3689571A (en) * | 1970-07-31 | 1972-09-05 | Baxter Laboratories Inc | Fluorinated ether |
| GB1499818A (en) * | 1974-12-06 | 1978-02-01 | Ici Ltd | Anaesthetic composition |
| US4469898A (en) * | 1979-12-26 | 1984-09-04 | Baxter Travenol Laboratories, Inc. | Method of synthesizing fluoromethylhexafluoroisopropyl ether |
| US4250334A (en) * | 1979-12-26 | 1981-02-10 | Baxter Travenol Laboratories, Inc. | Method of synthesizing fluoromethylhexafluoroisopropyl ether |
| JP2786108B2 (ja) * | 1994-03-31 | 1998-08-13 | セントラル硝子株式会社 | フルオロメチル−１，１，１，３，３，３−ヘキサフルオロイソプロピルエーテルの精製方法 |
| IT1270239B (it) * | 1994-06-17 | 1997-04-29 | Zambon Spa | Composizione farmaceutica solida contenente acido (s)-2-(4- isobutilfenil) propionico come principio attivo |
| US5990176A (en) * | 1997-01-27 | 1999-11-23 | Abbott Laboratories | Fluoroether compositions and methods for inhibiting their degradation in the presence of a Lewis acid |
-
1997
- 1997-01-27 US US08/789,679 patent/US5990176A/en not_active Expired - Lifetime
-
1998
- 1998-01-19 ZA ZA98418A patent/ZA98418B/xx unknown
- 1998-01-23 EP EP01107733A patent/EP1114641B1/en not_active Expired - Lifetime
- 1998-01-23 DK DK01107733T patent/DK1114641T3/da active
- 1998-01-23 TR TR1999/01579T patent/TR199901579T2/xx unknown
- 1998-01-23 KR KR10-1999-7006724A patent/KR100368672B1/ko not_active Ceased
- 1998-01-23 EP EP98902707A patent/EP0967975B1/en not_active Revoked
- 1998-01-23 NZ NZ335994A patent/NZ335994A/xx not_active IP Right Cessation
- 1998-01-23 CA CA002278133A patent/CA2278133C/en not_active Expired - Lifetime
- 1998-01-23 JP JP53216898A patent/JP3183520B2/ja not_active Expired - Lifetime
- 1998-01-23 CA CA002626424A patent/CA2626424A1/en not_active Abandoned
- 1998-01-23 AU AU59300/98A patent/AU726733B2/en not_active Expired
- 1998-01-23 BR BR9806996-9A patent/BR9806996A/pt active IP Right Grant
- 1998-01-23 DK DK98902707T patent/DK0967975T3/da active
- 1998-01-23 SK SK861-99A patent/SK284243B6/sk not_active IP Right Cessation
- 1998-01-23 CN CNA2006101016375A patent/CN1899271A/zh active Pending
- 1998-01-23 PT PT98902707T patent/PT967975E/pt unknown
- 1998-01-23 PL PL98334477A patent/PL334477A1/xx not_active IP Right Cessation
- 1998-01-23 DE DE69833884T patent/DE69833884T2/de not_active Expired - Lifetime
- 1998-01-23 DE DE69800928T patent/DE69800928T2/de not_active Revoked
- 1998-01-23 ES ES98902707T patent/ES2170474T3/es not_active Expired - Lifetime
- 1998-01-23 WO PCT/US1998/001376 patent/WO1998032430A1/en not_active Ceased
- 1998-01-23 ES ES01107733T patent/ES2256104T3/es not_active Expired - Lifetime
- 1998-01-23 HU HU0002101A patent/HUP0002101A3/hu unknown
- 1998-01-23 IL IL13015098A patent/IL130150A/en not_active IP Right Cessation
- 1998-01-23 AT AT01107733T patent/ATE320798T1/de active
- 1998-01-23 CZ CZ0256199A patent/CZ297092B6/cs not_active IP Right Cessation
- 1998-01-23 CN CNB2004100368062A patent/CN1321958C/zh not_active Expired - Lifetime
- 1998-01-23 CO CO98003122A patent/CO4920220A1/es unknown
- 1998-01-23 AT AT98902707T patent/ATE201987T1/de not_active IP Right Cessation
- 1998-01-23 PT PT01107733T patent/PT1114641E/pt unknown
- 1998-01-23 CN CNB98802053XA patent/CN1152674C/zh not_active Expired - Lifetime
- 1998-01-26 AR ARP980100336A patent/AR011090A1/es active IP Right Grant
-
1999
- 1999-07-23 NO NO19993606A patent/NO993606L/no not_active Application Discontinuation
- 1999-08-10 BG BG103656A patent/BG65414B1/bg unknown
- 1999-08-10 BG BG109751A patent/BG109751A/bg unknown
- 1999-11-23 US US09/447,853 patent/US6288127B1/en not_active Expired - Lifetime
-
2000
- 2000-11-16 JP JP2000349024A patent/JP3664648B2/ja not_active Expired - Lifetime
-
2001
- 2001-07-06 GR GR20010401038T patent/GR3036190T3/el not_active IP Right Cessation
- 2001-08-08 US US09/924,573 patent/US6444859B2/en not_active Expired - Lifetime
-
2002
- 2002-07-03 US US10/190,271 patent/US6677492B2/en not_active Expired - Lifetime
-
2003
- 2003-06-26 US US10/606,821 patent/US20040048932A1/en not_active Abandoned
-
2005
- 2005-04-06 JP JP2005109476A patent/JP2005279283A/ja not_active Ceased
- 2005-12-27 JP JP2005374621A patent/JP2006143742A/ja not_active Ceased
- 2005-12-27 JP JP2005374622A patent/JP2006137769A/ja not_active Ceased
-
2006
- 2006-02-27 US US11/362,954 patent/US20060148906A1/en not_active Abandoned
- 2006-11-16 AR ARP060105042A patent/AR057610A2/es unknown
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