ATE195313T1 - 3-substituierte 1-arylindolverbindungen - Google Patents

3-substituierte 1-arylindolverbindungen

Info

Publication number: ATE195313T1
Authority: AT; Austria
Prior art keywords: alkyl; hydrogen; group; alkenyl; formula
Prior art date: 1993-12-16

Application number

AT95903771T

Other languages

English (en)

Inventor

Kim Andersen

Jens Kristian Perregaard

Original Assignee

Lundbeck & Co As H

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-12-16

Filing date

1994-12-15

Publication date

2000-08-15

1994-12-15 Application filed by Lundbeck & Co As H filed Critical Lundbeck & Co As H

2000-08-15 Application granted granted Critical

2000-08-15 Publication of ATE195313T1 publication Critical patent/ATE195313T1/de

Links

150000001875 compounds Chemical class 0.000 title abstract 3
125000000217 alkyl group Chemical group 0.000 abstract 7
229910052739 hydrogen Inorganic materials 0.000 abstract 5
239000001257 hydrogen Substances 0.000 abstract 5
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 3
125000003342 alkenyl group Chemical group 0.000 abstract 3
229910052760 oxygen Inorganic materials 0.000 abstract 3
229910052717 sulfur Inorganic materials 0.000 abstract 3
210000003169 central nervous system Anatomy 0.000 abstract 2
150000002431 hydrogen Chemical class 0.000 abstract 2
125000002030 1,2-phenylene group Chemical group [H]C1=C([H])C([*:1])=C([*:2])C([H])=C1[H] 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
230000001090 anti-dopaminergic effect Effects 0.000 abstract 1
230000001705 anti-serotonergic effect Effects 0.000 abstract 1
125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
125000006355 carbonyl methylene group Chemical group [H]C([H])([*:2])C([*:1])=O 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
125000001183 hydrocarbyl group Chemical group 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
125000001434 methanylylidene group Chemical group [H]C#[*] 0.000 abstract 1
125000005699 methyleneoxy group Chemical group [H]C([H])([*:1])O[*:2] 0.000 abstract 1
125000002757 morpholinyl group Chemical group 0.000 abstract 1
125000003386 piperidinyl group Chemical group 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1
125000003107 substituted aryl group Chemical group 0.000 abstract 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/12—Radicals substituted by oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
- C07D209/16—Tryptamines
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/36—Oxygen atoms in position 3, e.g. adrenochrome

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Anesthesiology (AREA)
Addiction (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Indole Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
Polyesters Or Polycarbonates (AREA)

AT95903771T 1993-12-16 1994-12-15 3-substituierte 1-arylindolverbindungen ATE195313T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DK931395A DK139593D0 (da)	1993-12-16	1993-12-16	Compounds
PCT/DK1994/000470 WO1995016684A1 (en)	1993-12-16	1994-12-15	3-substituted 1-arylindole compounds

Publications (1)

Publication Number	Publication Date
ATE195313T1 true ATE195313T1 (de)	2000-08-15

Family

ID=8104386

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT95903771T ATE195313T1 (de)	1993-12-16	1994-12-15	3-substituierte 1-arylindolverbindungen

Country Status (24)

Country	Link
US (1)	US5789404A (de)
EP (2)	EP0939077A3 (de)
JP (1)	JPH09506595A (de)
KR (1)	KR100363484B1 (de)
CN (1)	CN1080261C (de)
AT (1)	ATE195313T1 (de)
AU (1)	AU682915B2 (de)
CA (1)	CA2179179A1 (de)
CZ (1)	CZ285028B6 (de)
DE (1)	DE69425510T2 (de)
DK (2)	DK139593D0 (de)
ES (1)	ES2149959T3 (de)
FI (1)	FI962496A0 (de)
GR (1)	GR3034744T3 (de)
HU (1)	HU223318B1 (de)
IL (1)	IL111989A (de)
NO (1)	NO306671B1 (de)
NZ (1)	NZ277483A (de)
PL (1)	PL181253B1 (de)
PT (1)	PT734384E (de)
RU (1)	RU2139287C1 (de)
SK (1)	SK283451B6 (de)
WO (1)	WO1995016684A1 (de)
ZA (1)	ZA949918B (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPH10503501A (ja) *	1994-08-03	1998-03-31	アスタメディカアクチエンゲゼルシャフト	抗喘息、抗アレルギー、抗炎症及び免疫修飾作用を有するインドール、インダゾール、ピリドピロール及びピリドピラゾール誘導体
MY125942A (en)	1999-09-07	2006-09-29	Upjohn Co	Aminoalkoxy carbazoles for the treatment of cns diseases
RU2337906C2 (ru) *	2001-12-03	2008-11-10	Уайт	Ингибиторы цитозольной фосфолипазы а2
DE60329607D1 (de) *	2002-06-21	2009-11-19	Suven Life Sciences Ltd	Sich als therapeutische mittel eignende arylalkylindole mit affinität für den serotoninrezeptor, verfahren zu deren herstellung und pharmazeutische zusammensetzungen, die diese enthalten
ES2276109T3 (es) *	2002-06-21	2007-06-16	Suven Life Sciences Limited	Nuevos indoles arilcarbonilicos tetraciclicos que tienen afinidad por el receptor de serotonina, utiles como agentes terapeuticos, proceso para su preparacion y mezclas farmaceuticas que los contienen.
WO2005118539A1 (en) *	2004-06-01	2005-12-15	F.Hoffmann-La Roche Ag	3-amino-1-arylpropyl indoles as monoamine reuptake inhibitor
WO2007136790A2 (en)	2006-05-18	2007-11-29	Mannkind Corporation	Intracellular kinase inhibitors

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1220628A (en) *	1968-07-20	1971-01-27	Pfizer Ltd	N-phenyl indole derivatives and pharmaceutical compositions thereof
GB1237008A (en) *	1968-12-18	1971-06-30	Pfizer Ltd	Novel indoline derivatives
DE1911893A1 (de) *	1969-03-08	1970-09-24	Thiemann Gmbh Chem Pharm Fabri	Verfahren zur Herstellung von N-(Halogen-aryl)-2-methyl-5-alkoxy-indol-3-essigsaeuren
SU385443A3 (de) *	1970-01-21	1973-05-29
BE795457A (fr) *	1972-02-16	1973-08-16	Clin Midy	Amines indoliques, leur preparation et leur application en therapeutiques
FR2242091A1 (en) *	1973-09-04	1975-03-28	Delalande Sa	1-Phenyl-2-methyl-3-aminomethyl-5-methoxy indole derivs - with e.g. analgesic, antidepressive and anti-arrhythmic props
US4558048A (en) *	1984-04-06	1985-12-10	Pfizer Inc.	Method of treating diarrhoea using indole compounds
DE3430284A1 (de) *	1984-08-17	1986-02-27	Troponwerke GmbH & Co KG, 5000 Köln	Neue tryptamin-derivate, ein verfahren zu ihrer herstellung und ihre verwendung
SE8701375D0 (sv) *	1987-04-02	1987-04-02	Leo Ab	Novel pyridyl- and pyrimidyl derivatives
DK152090D0 (da) *	1990-06-22	1990-06-22	Lundbaek A S H	Piperidylsubstituerede indolderivater
DK158590D0 (da) *	1990-07-02	1990-07-02	Lundbeck & Co As H	Indolderivater
DK36391D0 (da) *	1991-03-01	1991-03-01	Lundbeck & Co As H	Anvendelse af piperidylsubstituerede indolderivater til behandling af stofmisbrug
FR2701026B1 (fr) *	1993-02-02	1995-03-31	Adir	Nouveaux dérivés de l'indole, de l'indazole et du benzisoxazole, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.
FR2705346B1 (fr) *	1993-05-18	1995-08-11	Union Pharma Scient Appl	Nouveaux dérivés de pipéridinyl thio indole, leurs procédés de préparation, compositions pharmaceutiques les contenant, utiles notamment comme antalgiques .
US5504101A (en) *	1994-05-06	1996-04-02	Allelix Biopharmaceuticals, Inc.	5-HT-1D receptor ligands

1993
- 1993-12-16 DK DK931395A patent/DK139593D0/da not_active Application Discontinuation
1994
- 1994-12-13 ZA ZA949918A patent/ZA949918B/xx unknown
- 1994-12-15 PT PT95903771T patent/PT734384E/pt unknown
- 1994-12-15 IL IL11198994A patent/IL111989A/xx not_active IP Right Cessation
- 1994-12-15 WO PCT/DK1994/000470 patent/WO1995016684A1/en not_active Ceased
- 1994-12-15 US US08/666,380 patent/US5789404A/en not_active Expired - Fee Related
- 1994-12-15 CN CN94194964A patent/CN1080261C/zh not_active Expired - Fee Related
- 1994-12-15 PL PL94315027A patent/PL181253B1/pl not_active IP Right Cessation
- 1994-12-15 SK SK758-96A patent/SK283451B6/sk unknown
- 1994-12-15 EP EP99106459A patent/EP0939077A3/de not_active Withdrawn
- 1994-12-15 RU RU96115139/04A patent/RU2139287C1/ru not_active IP Right Cessation
- 1994-12-15 AU AU12721/95A patent/AU682915B2/en not_active Ceased
- 1994-12-15 AT AT95903771T patent/ATE195313T1/de not_active IP Right Cessation
- 1994-12-15 DE DE69425510T patent/DE69425510T2/de not_active Expired - Fee Related
- 1994-12-15 ES ES95903771T patent/ES2149959T3/es not_active Expired - Lifetime
- 1994-12-15 DK DK95903771T patent/DK0734384T3/da active
- 1994-12-15 CA CA002179179A patent/CA2179179A1/en not_active Abandoned
- 1994-12-15 EP EP95903771A patent/EP0734384B1/de not_active Expired - Lifetime
- 1994-12-15 NZ NZ277483A patent/NZ277483A/en unknown
- 1994-12-15 CZ CZ961727A patent/CZ285028B6/cs not_active IP Right Cessation
- 1994-12-15 JP JP7516476A patent/JPH09506595A/ja active Pending
- 1994-12-15 KR KR1019960703199A patent/KR100363484B1/ko not_active Expired - Fee Related
- 1994-12-15 HU HU9601640A patent/HU223318B1/hu not_active IP Right Cessation
1996
- 1996-06-13 NO NO962505A patent/NO306671B1/no unknown
- 1996-06-14 FI FI962496A patent/FI962496A0/fi unknown
2000
- 2000-11-02 GR GR20000402432T patent/GR3034744T3/el not_active IP Right Cessation

Also Published As

Publication number	Publication date
SK283451B6 (sk)	2003-08-05
JPH09506595A (ja)	1997-06-30
CZ285028B6 (cs)	1999-05-12
FI962496A7 (fi)	1996-06-14
IL111989A0 (en)	1995-03-15
NO962505D0 (no)	1996-06-13
NO306671B1 (no)	1999-12-06
KR100363484B1 (ko)	2003-02-05
CZ172796A3 (en)	1996-11-13
EP0939077A3 (de)	2003-11-19
DE69425510D1 (de)	2000-09-14
DE69425510T2 (de)	2001-04-19
PL315027A1 (en)	1996-09-30
PT734384E (pt)	2000-12-29
AU682915B2 (en)	1997-10-23
GR3034744T3 (en)	2001-02-28
EP0939077A2 (de)	1999-09-01
NO962505L (no)	1996-08-12
DK0734384T3 (da)	2001-01-02
DK139593D0 (da)	1993-12-16
KR960706492A (ko)	1996-12-09
FI962496A0 (fi)	1996-06-14
HU9601640D0 (en)	1996-08-28
EP0734384B1 (de)	2000-08-09
US5789404A (en)	1998-08-04
PL181253B1 (pl)	2001-06-29
RU2139287C1 (ru)	1999-10-10
AU1272195A (en)	1995-07-03
CA2179179A1 (en)	1995-06-22
NZ277483A (en)	1998-05-27
WO1995016684A1 (en)	1995-06-22
ZA949918B (en)	1995-08-23
SK75896A3 (en)	1996-11-06
IL111989A (en)	2000-10-31
ES2149959T3 (es)	2000-11-16
HK1013815A1 (en)	1999-09-10
HU223318B1 (hu)	2004-05-28
CN1080261C (zh)	2002-03-06
HUT76276A (en)	1997-07-28
CN1142824A (zh)	1997-02-12
EP0734384A1 (de)	1996-10-02

Legal Events

Date	Code	Title	Description
2001-01-15	UEP	Publication of translation of european patent specification
2004-09-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
FI931888A0 (fi)	1993-04-27	Kramploesande cykliska fruktopyranossulfiter -och sulfater
ATE251141T1 (de)	2003-10-15	Benzamidin-derivate, deren herstellung und deren verwendung als anti-koagulantien
ATE36149T1 (de)	1988-08-15	Antikonvulsive sulfamatderivate.
NO1998008I1 (no)	1998-02-05	Naratriptan
HUT70513A (en)	1995-10-30	Piperazine derivatives as 5-ht receptors antagonists, pharmaceutical compositions comprising them and method for producing thereof
FI893751A0 (fi)	1989-08-09	Kemiska foereningar.
SE8505887D0 (sv)	1985-12-12	Indoler
DE69202120D1 (de)	1995-05-24	Harnstoffderivate, ihre Herstellung und ihre Verwendung bei der Therapie.
DK0734384T3 (da)	2001-01-02	3-substituerede 1-arylindolforbindelser
LV10235A (lv)	1994-10-20	Jauni esteri to iegusanas panemiens farmaceitiska kompozicija arstesanas metode
ATE83234T1 (de)	1992-12-15	Oxadiazol-pyrimidinone, ihre herstellung und ihre kosmetische und dermopharmazeutische verwendung.
SE8303913L (sv)	1984-01-09	Heterocykliska foreningar
DE69616357D1 (de)	2001-11-29	Benzocycloalken-verbindungen mit bindungsaffinität an den melatonin-rezeptor, ihre herstellung und verwendung
ATE28639T1 (de)	1987-08-15	Derivate von 4-(3-alkynyloxy-2-hydroxy-propyl)piperazin-1-yl-n-phenylacetamid, ihre herstellung und ihre therapeutische verwendung.
FI860074A0 (fi)	1986-01-08	Oktahydroindolizinfoereningar anvaendbara som smaertstillande medel.
ATE24487T1 (de)	1987-01-15	Neue carbacycline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel.
FI915025A0 (fi)	1991-10-24	8-azabicyklo(3,2,1) oktylalkyltiazolidinoner, foerfarande foer deras framstaellning och deras anvaendning som laekemedel.
DE68909143D1 (de)	1993-10-21	Prostaglandin-Vorläufer und ihre Herstellung.
HUT45059A (en)	1988-05-30	Process for producing abeoergoline derivatives
DK0492350T3 (da)	1998-01-26	Fremgangsmåde til fremstilling af (S)-vinyl- og (S)-allenyl-GABA
ATE7694T1 (de)	1984-06-15	Derivate von 2-methyl-5-thiazolmethylamin und carboxamid.
DE69407042D1 (de)	1998-01-08	Psoralen-derivate, deren herstellung und verwendung als arzneimittel