AU2009237483B2 - Compositions for the treatment of lice - Google Patents
Compositions for the treatment of lice Download PDFInfo
- Publication number
- AU2009237483B2 AU2009237483B2 AU2009237483A AU2009237483A AU2009237483B2 AU 2009237483 B2 AU2009237483 B2 AU 2009237483B2 AU 2009237483 A AU2009237483 A AU 2009237483A AU 2009237483 A AU2009237483 A AU 2009237483A AU 2009237483 B2 AU2009237483 B2 AU 2009237483B2
- Authority
- AU
- Australia
- Prior art keywords
- lice
- composition
- composition according
- ectoparasitosis
- treatment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
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- HLZKNKRTKFSKGZ-UHFFFAOYSA-N tetradecan-1-ol Chemical compound CCCCCCCCCCCCCCO HLZKNKRTKFSKGZ-UHFFFAOYSA-N 0.000 description 2
- SBNFWQZLDJGRLK-RTWAWAEBSA-N (1R)-trans-phenothrin Chemical compound CC1(C)[C@H](C=C(C)C)[C@H]1C(=O)OCC1=CC=CC(OC=2C=CC=CC=2)=C1 SBNFWQZLDJGRLK-RTWAWAEBSA-N 0.000 description 1
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- PNNNRSAQSRJVSB-UHFFFAOYSA-N L-rhamnose Natural products CC(O)C(O)C(O)C(O)C=O PNNNRSAQSRJVSB-UHFFFAOYSA-N 0.000 description 1
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- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
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- PNNNRSAQSRJVSB-BXKVDMCESA-N aldehydo-L-rhamnose Chemical compound C[C@H](O)[C@H](O)[C@@H](O)[C@@H](O)C=O PNNNRSAQSRJVSB-BXKVDMCESA-N 0.000 description 1
- 208000030961 allergic reaction Diseases 0.000 description 1
- BTBJBAZGXNKLQC-UHFFFAOYSA-N ammonium lauryl sulfate Chemical compound [NH4+].CCCCCCCCCCCCOS([O-])(=O)=O BTBJBAZGXNKLQC-UHFFFAOYSA-N 0.000 description 1
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- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
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- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- VEMKTZHHVJILDY-UXHICEINSA-N bioresmethrin Chemical compound CC1(C)[C@H](C=C(C)C)[C@H]1C(=O)OCC1=COC(CC=2C=CC=CC=2)=C1 VEMKTZHHVJILDY-UXHICEINSA-N 0.000 description 1
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- DLAHAXOYRFRPFQ-UHFFFAOYSA-N dodecyl benzoate Chemical compound CCCCCCCCCCCCOC(=O)C1=CC=CC=C1 DLAHAXOYRFRPFQ-UHFFFAOYSA-N 0.000 description 1
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- SFNALCNOMXIBKG-UHFFFAOYSA-N ethylene glycol monododecyl ether Chemical compound CCCCCCCCCCCCOCCO SFNALCNOMXIBKG-UHFFFAOYSA-N 0.000 description 1
- NUVBSKCKDOMJSU-UHFFFAOYSA-N ethylparaben Chemical compound CCOC(=O)C1=CC=C(O)C=C1 NUVBSKCKDOMJSU-UHFFFAOYSA-N 0.000 description 1
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- 125000003976 glyceryl group Chemical group [H]C([*])([H])C(O[H])([H])C(O[H])([H])[H] 0.000 description 1
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- 231100000618 neurotoxin Toxicity 0.000 description 1
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- 230000007170 pathology Effects 0.000 description 1
- RLLPVAHGXHCWKJ-UHFFFAOYSA-N permethrin Chemical compound CC1(C)C(C=C(Cl)Cl)C1C(=O)OCC1=CC=CC(OC=2C=CC=CC=2)=C1 RLLPVAHGXHCWKJ-UHFFFAOYSA-N 0.000 description 1
- 229960000490 permethrin Drugs 0.000 description 1
- 239000003208 petroleum Substances 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 229960003536 phenothrin Drugs 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 239000002574 poison Substances 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
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- 239000000843 powder Substances 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 235000010232 propyl p-hydroxybenzoate Nutrition 0.000 description 1
- 239000004405 propyl p-hydroxybenzoate Substances 0.000 description 1
- 229960003415 propylparaben Drugs 0.000 description 1
- 239000002728 pyrethroid Substances 0.000 description 1
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- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
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- 229910021653 sulphate ion Inorganic materials 0.000 description 1
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- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 229940099259 vaseline Drugs 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/14—Ectoparasiticides, e.g. scabicides
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Tropical Medicine & Parasitology (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Cosmetics (AREA)
Abstract
The present invention provides a composition comprising glycerine, petrolatum and VP/hexadecane copolymer that is suitable for use in the treatment of lice infections. The present invention also provides methods of administering a composition such that lice, eggs and nits are eradicated from the host.
Description
WO 2009/127830 PCT/GB2009/000982 1 COMPOSITIONS FOR THE TREATMENT OF LICE Field of the Invention The present invention relates to compositions for treating lice infestations. Background to the Invention 5 Infestation of the human body by lice is a prevalent social and health problem in many countries. There are three anatomically distinct types of lice that infest humans, namely head lice, body lice and crab lice. Head lice are small hard-shelled obligate ectoparasites that spend their entire life on the human scalp and feed exclusively on human blood. A female 10 louse has a life span of 4 weeks, during which time it lays 50-100 eggs. Eggs are attached firmly to the hair shaft using chitin secreted by the female. The eggs hatch after 6-9 days, and the nymph emerges leaving behind the non viable shell or "nit". Following three cycles of moulting, the nymph develops into an adult louse capable of reproducing. 15 Head lice infestations are most common in children aged 4-11, and are more prevalent in females than in males. Lice are spread by direct contact with an infested person. The presence of head lice can be signalled by itching caused by an allergic reaction to louse saliva. There may also be visual evidence of the presence of lice, eggs or nits. 20 The objective when treating head lice infestations must be to free the host of eggs, nymphs, lice and nits, for the continued presence of the latter can only serve to confuse later diagnosis. It is preferable that the treatment be easy to carry out, inexpensive, and associated with minimal side-effects. Conventional head lice management usually involves the use of 25 neurotoxic insecticide lotions in combination with wet combing. Combing, using a fine-toothed plastic comb for the detection and removal of adult lice and a metal comb for eggs and nits, is viewed as a safe method of elimination but is a laborious process and a heavy burden on parents. Commonly used insecticidal treatments, or pediculicides, are generally pyrethroid-based (e.g. Full Marks@), 30 malathion-based (e.g. Derbac-M@) or carbaryl-based (e.g. Carylderm@). Pyrethroids, such as permethrin and phenothrin, are synthetic axionic poisons which cause nervous hyper-excitability leading to death. Malathion is an organophosphate parasympathomimetic which binds irreversibly to WO 2009/127830 PCT/GB2009/000982 2 cholinesterase. Carbaryl (1-naphthyl methylcarbamate) is also a cholinesterase inhibitor. However, there is evidence that these current chemical treatments fail to resolve the pathology of lice infestations and are significantly disadvantageous 5 because they are associated with side-effects such as scalp irritation and are highly toxic if ingested orally. Carbaryl is also potentially carcinogenic. Furthermore, there is also evidence of lice populations developing resistance to many of the commonly used pediculicides and concern about the safety of neurotoxin-based treatments, particularly when used to treat very young 10 subjects. Alternative treatments containing essential oils, herbal extracts or homeopathic tinctures are also available, although there is no scientific evidence to demonstrate their efficacy. Dimeticone-based products kill lice by inhibiting their ability to excrete surplus water. They are not traditional insecticides and 15 have a good safety profile and are therefore recommended for pregnant or breastfeeding women. However, dimeticone is not thought to be effective in removing eggs from the host. Therefore, there is a need for the development of new compositions which enable the safe and effective treatment of head lice and avoid the 20 problems of induced resistance. Summary of the Invention The present invention relates to compositions suitable for use in the treatment of lice infestations. The present invention is also directed to methods of administering a composition such that lice, eggs and nits are eradicated from 25 the host. According to a first aspect of the invention, a composition comprises glycerine, petrolatum and VP-hexadecene copolymer. According to a second aspect of the invention, such a composition is used in therapy, particularly for the topical treatment of ectoparasitosis. 30 According to a third aspect of invention, a method of treating ectoparasitosis comprises contacting the infested area of the subject with the composition of the invention.
WO 2009/127830 PCT/GB2009/000982 3 Detailed Description of the Invention The present invention provides a composition that is useful in the topical treatment of ectoparasitosis, and in particular the treatment of pediculosis. 5 The term "ectoparasite" is defined herein as a parasite that lives on the external surface of a host. The term "ectoparasitosis" refers to an infestation of ectoparasites. As used herein, the term "pediculosis" refers to a lice infestation. The three genera of lice which affect humans are Pediculosis humanus capitis (head 10 lice), Pediculosis humanus corporis (body lice) and Pthirus pubis (crab lice). The composition of the present invention is intended for use in the treatment of mammalian ectoparasitosis. In a preferred embodiment, the ectoparasitosis to be treated by use of the composition is pediculosis. More preferably, the pediculosis is a human lice infestation, and most preferably a 15 head lice infestation. As used herein, the term "pediculicide" refers to a pharmaceutical composition for the treatment of pediculosis. As used herein, the terms "subject" and "host" are used interchangeably and refer to a mammal including a non-primate (e.g. a cow, pig, horse, cat, dog, 20 rat and mouse) and a primate (e.g. a monkey and a human), and preferably a human. The composition of the invention is a liquid formulation comprising glycerine, petrolatum and vinylpyrrolidine (VP)/hexadecene copolymer. As used herein, the term "glycerine" is intended to encompass all terms 25 used to describe the compound propane-1,2,3-triol which has the chemical formula HOCH 2
CH(OH)CH
2 OH. As used herein, the term "petrolatum" refers to pharmaceutical-grade or cosmetic-grade petrolatum and includes all synonyms including petroleum jelly and paraffin jelly. Petrolatum is a colourless to yellowish-white non-polar 30 hydrocarbon mixture obtained by fractional distillation of petroleum and is commercially available under the brand name Vaseline@. As used herein, the term "VP/hexadecene copolymer" refers to the coplymer of vinylpyrrolidine and long chain a-olefins. VP/hexadecene copolymer WO 2009/127830 PCT/GB2009/000982 4 is a pale yellow viscous liquid commonly added to cosmetic products for its wear-resistance and moisture barrier-forming properties and is available commercially as Antaron@V-216 or Ganex@V-216. In a preferred embodiment the composition of the invention also 5 comprises either, or both, pectin and xanthan gum. As used herein, the term 'pectin' refers to a heteropolysaccharide derived from the cell wall of higher terrestrial plants that is commonly used as a gelling agent, a thickening agent and a stabilizer in food. The characteristic structure is a linear homogalacturonan with substituted regions of (1-2)-linked L-rhamnose. 10 Isolated pectin is a white to light-brown powder and has a molecular weight of typically 60-130 000 g/mol, varying with origin and extraction conditions. As used herein, the term 'xanthan gum' refers to a polysaccharide produced during the fermentation of glucose or sucrose by the Xanthomonas campestris bacterium. Xanthan gum is useful industrially since a very small 15 quantity of gum (in the order of 0.5-1%) is capable of producing a large increase in the viscosity of a liquid. Typically, the composition comprises 0.1-5% w/w glycerine, 0.1-5% w/w petrolatum, 0.1-5% w/w VP-hexadecene polymer, 0.05-2 % w/w pectin and 0.05 2 % w/w xanthan gum. 20 In a further preferred embodiment, the composition also comprises a surfactant, preferably an anionic surfactant. Suitable cosmetic-grade surfactants are known in the art and include sodium dodecasulphate (SDS), ammonium lauryl sulphate, sodium laureth sulphate, soaps and fatty acid salts. In a preferred embodiment, the pediculicide of the invention is a liquid 25 formulation, preferably an aqueous lotion. Ingredients of the formulation include, but are not limited to, water, cosmetic-grade emollients such as cetearyl alcohol, emulsifiers such as staareth-21, anti-static agents such as behentrimonium chloride, humectants such as propylene glycol, sorbitol, and glyceryl stearate citrate , moisturisers 30 such as propylene glycol, preservatives such as parabens and phenoxyethanol and fragrant esters. The formulation may optionally further comprise cosmetic grade dyes and colour agents. Table 1 provides a non-limiting example of the composition according to the invention.
WO 2009/127830 PCT/GB2009/000982 5 Table 1: % w/w composition Aqua 68.80 C12-15 alkyl benzoate 16.00 Myristyl alcohol 2.85 Cetearyl alcohol 2.50 Behentrimonium chloride 1.80 Glycerin 1.50 Glyceryl strearate citrate 1.35 Petrolatum 1.00 VP/hexadecene copolymer 1.00 Steareth-21 1.00 Pectin 0.60 Phenoxyethanol 0.50 Xanthan gum 0.40 Propylene glycol 0.25 Benzyl alcohol 0.20 Methylparaben 0.10 Ethylparaben 0.10 Propylparaben 0.05 100.00 5 According to a further embodiment of the invention, the pediculicide is applied to the dry hair of an infested subject in a quantity sufficient to cover the entire area. It is preferable for the hair to then be wrapped in a plastic wrap or 'cling film'. The composition adheres to the hair shaft, forming a continuous 10 impermeable film which prevents the lice and eggs from obtaining oxygen, thereby causing suffocation and death. In a preferred embodiment, the composition is left on the hair for a length of time sufficient to kill the lice and eggs by suffocation action. In a preferred embodiment, the composition is left on the hair for between 40 to 80 minutes, WO 2009/127830 PCT/GB2009/000982 6 more preferably for 60 minutes, and then removed by rinsing with water. The presence of an anionic surfactant facilitates removal of the solution. Dead lice and eggs can be removed by wet combing the hair using a fine-toothed comb (teeth 0.2 to 0.3mm apart). 5 In order to ensure effective removal of all lice and nits, subjects should preferably be treated twice a day for up to three days. In a more preferred embodiment, the treatment is repeated after fifteen days to ensure eradication of any lice or eggs that may have persisted following the first treatment. Since the pediculicide of the invention employs a physical rather than biochemical mode of 10 action, lice populations are not able to develop resistance and therefore the efficacy of the treatment will not decline over time. The present invention will now be exemplified by the following non limiting example: Example 15 The following efficacy study was performed on 13 subjects suffering from pediculosis. 11 of the subjects were female and 2 were male, and all were between the ages of 8 and 40 years old. In all subjects lice were found close to the scalp and itching was reported. Two versions of the pediculicide composition of the invention were 20 prepared, one having a creamy consistency and one having a fluid consistency. The creamy version of the pediculicide was tested on 5 subjects and the fluid version was tested on 8 subjects. The components of the composition is as set out in Table 1. In each case, the pediculicide was applied to the entire crop of dry hair, 25 which was then wrapped in cling film and left for approximately 2 hours. The product was then removed by normal shampooing and then the hair was combed with a fine toothed comb. This process was repeated after one week and all subjects were inspected for the presence of lice one month after the first application. 30 The results of the study are summarised in Table 2: 7 Table 2: Subject (Year Product Initial Result after 1 Result after Comments of birth/sex) consistency observations week 1 month 1996 / F Cream Many lice Some lice remain All lice No problems 5 removed when 15cm from scalp, removed reported combing itching stopped 1999 / F Cream Loss of one louse Some lice remain All lice Complained when combing 15cm from scalp. removed of bad smell Itching stopped of product 1999 /F Cream Many lice Some lice remain All lice No problems removed when 20cm from scalp. removed reported combing Itching stopped 1994/ M Cream No loss of lice Some lIce remain All lice No problems distant from scalp. removed reported 0 1999 /F Cream No loss of (ice Some lice remain All lce No problems distant from scalp. removed reported 1995 / F Fluid Many lice Some lice remain All lice Product removed when distant from scalp. removed trickled when combing Itching stopped applied 1996 /F Fluid No loss of lice All lce removed All lice No problems removed reported 1996 / F Fulud Many lice Some lice remain All lice No problems removed when distant from scalp. removed reported combing 5 1968 I F Fluid No loss of lice Some lice remain All lice No problems - distant from scalp. removed reported 1966 / F Fluid Loss of two lice Some lice remain All lice No problems when combing distant from scalp. removed reported 1999 / Fluid Loss of one louse Some lice remain All lice Io problems when combing distant from scalp. removed reported 1999 / F Fluid Loss of two lice All lice removed All lice No problems when combing I removed reported 1999 / M Fluid No loss of lice All lice removed All lice No problems 0 removed reported These results show that the removal of lice immediately following the first application of the composition was seen in 8 subjects. After one week, only empty shells and dry nits were observed, and these were away from the scalp in all subjects. Inspection one month after the first application showed 25 that all subjects were negative for the presence of lice or nits. One the whole, the composition proved satisfactory to all, without any manifestation of intolerance, itching, irritation or burning sensation at the time of application. It will be understood that the term "comprise" and any of its derivatives (eg. comprises, 30 comprising) as used in this specification is to be taken to be inclusive of features to which it refers, and is not meant to exclude the presence of any additional features unless otherwise stated or implied. The reference to any prior art in this specification is not, and should not be taken as, an acknowledgement of any form of suggestion that such prior art forms part of the common general 35 knowledge.
8 It will be appreciated by those skilled in the art that the invention is not restricted in its use to the particular application described. Neither is the present invention restricted in its preferred embodiment with regard to the particular elements and/or features described or depicted herein. It will be appreciated that various modifications can be made without departing from the principles of the invention. Therefore, 5 the invention should be understood to include all such modifications in its scope.
Claims (23)
1. A composition comprising glycerine, petrolatum and VP/hexadecene copolymer. 5
2. A composition according to claim 1, further comprising pectin.
3. A composition according to claim 1 or claim 2, further comprising xanthan gum.
4. A composition according to any one of the preceding claims, further comprising a surfactant. 10
5. A composition according to claim 4, wherein the surfactant is an anionic surfactant.
6. A composition according to any one of the preceding claims, comprising a concentration of 0.1 5% w/w glycerine, 0.1-5% w/w petrolatum, 0.1-5% w/w VP/hexadecene copolymer, 0.05-2% w/w pectin 15 and 0.05-2% w/w xanthan gum.
7. A pediculicide comprising a composition according to any one of the preceding claims.
8. A pediculicide according to claim 7, wherein the composition is a liquid formulation. 20
9. A pediculicide according to claim 8, wherein the formulation is an aqueous lotion.
10. A composition according to any one of claims I to 6, for use in therapy. 25
11. A composition according to claim 10, wherein the therapy is topical treatment of ectoparasitosis in mammals.
12. A composition according to claim 11, wherein the ectoparasitosis is in a human subject. 30
13. A composition according to claim 12, wherein the ectoparasitosis is pediculosis.
14. A composition according to claim 13, wherein the pediculosis is head lice.
15. A method of treating ectoparasitosis, comprising contacting the infested area of a subject with the 35 composition according to any one of claims 1 to 6.
16. A method according to claim 15, wherein the ectoparasitosis is pediculosis. 10
17. A method according to claim 16, wherein the pediculosis is head lice.
18. A method according to claim 17, wherein the hair is dry at the time of contact. 5
19. A method according to claim 18, wherein the composition is in contact with the hair for a length of time sufficient to kill the lice by suffocation,
20. A method according to claim 19, wherein the composition is in contact with the hair for 40 to 80 10 minutes per treatment.
21. A method according to claim 20, wherein treatment is repeated twice a day for up to three days.
22. The composition of claim I substantially as hereinbefore described. 15
23. The method of claim 15 substantially as hereinbefore described.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0806948.6 | 2008-04-16 | ||
| GBGB0806948.6A GB0806948D0 (en) | 2008-04-16 | 2008-04-16 | Composition |
| PCT/GB2009/000982 WO2009127830A1 (en) | 2008-04-16 | 2009-04-16 | Compositions for the treatment of lice |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2009237483A1 AU2009237483A1 (en) | 2009-10-22 |
| AU2009237483B2 true AU2009237483B2 (en) | 2012-05-10 |
Family
ID=39472220
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2009237483A Expired - Fee Related AU2009237483B2 (en) | 2008-04-16 | 2009-04-16 | Compositions for the treatment of lice |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP2296623A1 (en) |
| KR (1) | KR20110015524A (en) |
| CN (1) | CN102006858A (en) |
| AU (1) | AU2009237483B2 (en) |
| CA (1) | CA2721649A1 (en) |
| GB (1) | GB0806948D0 (en) |
| IL (1) | IL208624A0 (en) |
| WO (1) | WO2009127830A1 (en) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ITRM20090122A1 (en) * | 2009-03-23 | 2010-09-24 | Marco Nicoletti | COMPOSITION FOR COSMETIC BASIC CREAM AND ITS PREPARATION PROCEDURE |
| LU92931B1 (en) * | 2015-12-24 | 2017-07-20 | Pihuit S A | COMPOSITION AND METHOD OF PEST CONTROL |
| CZ2017210A3 (en) * | 2017-04-18 | 2018-08-22 | Vakos Xt A.S. | A composition for killing lice |
| WO2017198241A1 (en) * | 2016-05-19 | 2017-11-23 | Vakos Xt A.S. | A lice killing agent |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB564729A (en) * | 1940-06-26 | 1944-10-11 | Cooper Mcdougall & Robertson | Improved insecticide |
| GB572310A (en) * | 1942-12-31 | 1945-10-02 | Mckesson & Robbins Inc | Parasiticides |
| WO2000072814A1 (en) * | 1999-05-27 | 2000-12-07 | Eduardo Zancaner | Composition for cleaning and removing parasites from the hair |
| WO2007085899A2 (en) * | 2005-07-06 | 2007-08-02 | Foamix Ltd. | Foamable arthropocidal composition for tropical application |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10100409A1 (en) * | 2001-01-08 | 2002-07-11 | Beiersdorf Ag | Cosmetic and dermatological light protection formulations containing benzotriazole derivatives and surface-active sucrose esters |
| DE10162351A1 (en) * | 2001-12-18 | 2003-07-03 | Cognis Deutschland Gmbh | Cosmetic and / or pharmaceutical emulsions |
-
2008
- 2008-04-16 GB GBGB0806948.6A patent/GB0806948D0/en not_active Ceased
-
2009
- 2009-04-16 EP EP09731992A patent/EP2296623A1/en not_active Withdrawn
- 2009-04-16 KR KR1020107023989A patent/KR20110015524A/en not_active Withdrawn
- 2009-04-16 AU AU2009237483A patent/AU2009237483B2/en not_active Expired - Fee Related
- 2009-04-16 CN CN2009801133578A patent/CN102006858A/en active Pending
- 2009-04-16 WO PCT/GB2009/000982 patent/WO2009127830A1/en not_active Ceased
- 2009-04-16 CA CA2721649A patent/CA2721649A1/en not_active Abandoned
-
2010
- 2010-10-11 IL IL208624A patent/IL208624A0/en unknown
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB564729A (en) * | 1940-06-26 | 1944-10-11 | Cooper Mcdougall & Robertson | Improved insecticide |
| GB572310A (en) * | 1942-12-31 | 1945-10-02 | Mckesson & Robbins Inc | Parasiticides |
| WO2000072814A1 (en) * | 1999-05-27 | 2000-12-07 | Eduardo Zancaner | Composition for cleaning and removing parasites from the hair |
| WO2007085899A2 (en) * | 2005-07-06 | 2007-08-02 | Foamix Ltd. | Foamable arthropocidal composition for tropical application |
Also Published As
| Publication number | Publication date |
|---|---|
| KR20110015524A (en) | 2011-02-16 |
| WO2009127830A1 (en) | 2009-10-22 |
| AU2009237483A1 (en) | 2009-10-22 |
| CN102006858A (en) | 2011-04-06 |
| CA2721649A1 (en) | 2009-10-22 |
| EP2296623A1 (en) | 2011-03-23 |
| IL208624A0 (en) | 2010-12-30 |
| GB0806948D0 (en) | 2008-05-21 |
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