AU2012204059B2

AU2012204059B2 - Methods for generating new hair follicles, treating baldness and hair removal

Info

Publication number: AU2012204059B2
Application number: AU2012204059A
Authority: AU
Inventors: George Cotsarelis; Mayumi Ito
Original assignee: University of Pennsylvania Penn
Current assignee: University of Pennsylvania Penn
Priority date: 2005-03-29
Filing date: 2012-07-10
Publication date: 2015-01-15
Anticipated expiration: 2026-03-28
Also published as: AU2012204059A1

Abstract

The present invention provides methods of treating baldness in a subject and generating new hair follicles, comprising epidermal disruption and administration of a compound that promotes a differentiation of an uncommitted epidermal cell into a hair follicle cell. The present invention also 5 provides methods for hair removal and inducing hair pigmentation.

Description

1 METHODS FOR GENERATING NEW HAIR FOLLICLES, TREATING BALDNESS. AND HAIR REMOVAL FIELD OF INVENTION 5 [0001] The present invention provides methods of treating baldness in a subject and generating new hair follicles, comprising epidermal disruption and administration of a compound that promotes a differentiation of an uncommitted epidermal cell into a hair follicle cell. The present invention also provides methods for hair removal and inducing hair pigmentation. 10 BACKGROUND OF THE INVENTION [0002] Follicular neogenesis is defined as the generation of new hair follicles (HF) after birth. Humans are born with a full complement of HF, which can change in size and growth characteristics as in early baldness or can ultimately degenerate and disappear as in late stages of baldness or in permanent scarring (cicatricial) alopecias. Therefore, the 15 generation of new HF is desirable in the treatment of common baldness as well as less common hair loss conditions, such as discoid lupus erythematosis, congenital hypotrichosis, lichen planopilaris and other scarring alopecias. SUMMARY OF THE INVENTION 20 [0003] The present invention provides methods of treating baldness in a subject and generating new hair follicles (HF), comprising epidermal disruption and administration of a compound that promotes a differentiation of an uncommitted epidermal cell into a hair follicle cell. The present invention also provides methods for hair removal and inducing hair pigmentation. 25 [0004] In one embodiment, the present invention provides a method for treating baldness in a human subject comprising wounding an area of the balding scalp of said human subject, wherein the wounding-step comprises disrupting an epidermis or dermis of the area of the balding scalp; and contacting the wounded area of the balding scalp with minoxidil. 30 2 [0005] This paragraph has been left blank intentionally. [0006] This paragraph has been left blank intentionally. [0007] This paragraph has been left blank intentionally. [0008] This paragraph has been left blank intentionally. 5 [0009] This paragraph has been left blank intentionally. [00010] This paragraph has been left blank intentionally. [00011] This paragraph has been left blank intentionally. BRIEF DESCRIPTION OF THE FIGURES 10 [00012] Figure 1: Epidermal abrasion results in de novo hair follicle (HF) formation. HF at progressive stages of development are depicted in the left, center, and right panels. The arrow in the left panel indicates a hair germ. The dark stained cells are progeny of HF stem cells in the bulge. [00013] Figure 2: BrdU labeling of HF following epidermal abrasion. HF at progressive 15 stages of development are depicted in the left, center, and right panels. [00014] Figure 3. The wound site did not contain HF immediately after re-epithelialization. Top view (left panel) and tissue section (right panel) of the site 10 days after wound induction. [00015] Figure 4. Appearance of hair germs 12 days after wound induction. Arrow indicates 20 hair germ.

3 THIS PAGE HAS BEEN LEFT BLANK INTENTIONALLY] [00016] Figure 5. Epidermal Disruption-Induced HF neogenesis (EDIHN)-induced hair germs express K17. Two different hair germs are depicted in the left and right panels. [00017] Figure 6. EDIHN-induced hair germs contain dermal papilla (DP) cells, as evidenced by alkaline phosphatase (AP) staining. Arrows indicate DP cells. Left panel: hair germs. Right panel: 5 HF at a further developmental stage. [00018] Figure 7. Histological comparison between EDIHN-induced and embryonic HF. Top left, second from left, third from left, and right panels: Progressive stages of EDIHN-induced HF development. Bottom left, center, and right panels: Progressive stages of and embryonic HF development. 10 [00019] Figure 8. Induction of several markers of embryonic HF development, Lefl (left panel), wingless/ int (Wnt) 10b (center panel), and sonic hedgehog (Shh; right panel), by EDIHN. HF structures are indicated by arrowheads. [00020] Figure 9. Proliferative activity during EDIHN, as evidenced by BrdU pulse-labeling. Progressive stages of HF development are depicted in the left, center, and right panels. 15 [00021] Figure 10. Induction of HF markers Si 00A3 (left panel; tissue section parallel to HF axis) and S1 00A6 (right panel; cross-sectional view of follicle) by EDIHN. [00022] Figure 11. New hair growth 25 days (left panel) and 45 days (right panel) after wound induction. [00023] Figure 12. Schematic of whole-mount EDIHN assay. 20 [00024] Figure 13. Repopulation of stem cells in the bulge of EDIHN-induced HF, as evidenced by retention of BrdU label following a chase period. Left panel: lower magnification: 50 X. Right panel: higher magnification: 400 X. [00025] Figure 14. A. Stem cells in EDIHN-induced HF express K15. Left top panel: Top view of wound site. Bottom, far left panel: epidermis whole mount; bottom, second from left panel: same as -4- [bottom, far left] panel but viewed under white light; right panel: tissue sections. B. Neogenesis HF proceed to next hair cycle. [00026] Figure 15. Schematic of creation of new HF by EDIHN. [00027] Figure 16. No new HF are evident 11 days after wound induction in 21-day-old mice. Top 5 panel: macroscopic examination; bottom left panel: AP staining of the dermis; bottom right panel: K17 staining of the epidermis. [00028] Figure 17. 14 days after wound induction, new HF have begun to form as evidenced by AP staining of the dermis (left panel) and K17 staining of the epidermis (right panel). Main panels: 10 X magnification. Inserts: 80 X magnification. 10 [00029] Figure 18. 17 days after wound induction, new HF are more developed. Left panel: AP staining of the dermis; right panel: K1 7 staining of the epidermis. Main panels: 10 X magnification. Inserts: 80 X magnification. [00030] Figure 19. Wounds closed similar in mice subjected to depilation, then wounding (left 3 mice in each panel) vs. wounding alone (right 4 mice in each panel). Left panel: immediately 15 following wounding. Right panel: 10 days following wounding. [00031] Figure 20. Anagen induction by depilation prior to wounding enhances the efficiency of EDIHN. A. Top panel: lower left panel AP staining of the dermis; lower right panel: K1 7 staining of the epidermis. B. Graphical representation of enhancement of EDIHN by depilation. [00032] Figure 21. A. EDIHN in human skin grafted to immunodeficient (scid) mice, seven days 20 after induction of an excisional wound. Arrows indicate new HF. B. Dermal abrasion of human skin grafts results in EDIHN. Human adult skin (W) was grafted onto mice, abraded, and examined seven days later, by staining for S1 00A6 (first, second, and fourth rows) or S1 00A4 (third row). Hair germs (HG) and dermal papilla (DP) are indicated. Human fetal skin (F) with normal developing hair follicles is shown for comparison. Mouse skin 17d post wounding was included as a control 2 5 (top left panel). -5- [00033] Figure 22. Transcripts up-regulated at least 2-fold in activated HF cells, as assessed by dChip analysis. (A). Mean values and standard errors of the up-regulated transcripts in non-activated ("bs line") and activated ("expt") samples and fold-changes and differences between non-activated and activated values are depicted. (B). Raw data for up-regulated transcripts in non-activated and 5 activated cells. "Ctrl" denotes non-activated and "High-dep" denotes activated cells. (C). Additional information about up-regulated transcripts. [00034] Figure 23. Pigmented hair follicle neogenesis observed in the skin of Dkkl-expressing mice following EDIHN A. 3.2x magnification. B. 8x magnification. [00035] Figure 24. Control mice lacked pigmented HF. 10 [00036] Figure 25. EGF inhibits HF formation by EDIHN. A. K17 staining of wounded skin of representative mouse treated with EGF. Magnification is 4x. B. High magnification view (1 Ox) of skin depicted in (A). C. K17 staining of wounded skin of representative control mouse that received no EGF after wounding. Magnification is 4x. D. Higher magnification view (1 OX) of skin depicted in (D). 15 [00037] Figure 26. Administration of an EGF receptor inhibitor (AG1478) leads to generation of more and larger HF compared with controls. A. Top: skin of 2 control mice. Outer dashed line indicates the extent of the wounded area after contraction and healing; inner dashed line indicates the area of neogenesis. Bottom: skin of 2 treated mice, in which the wounded area and area of neogenesis largely coincide, with the exception of a small area on the left side of the encircled area 2 0 in each panel. B. Large hair follicles developed in the wounded area in the AG1478-injected mice. Left panel: epidermis stained for K17, with three large hair follicles next to each other. Right panel: dermis stained for AP with large coalescing DP areas. Scale Bars: 200 pm. [00038] Figure 27. A. Increased hair follicle formation in K14-Wnt7a mice. Left panel: Wnt7a transgenic mice. Right panel: control (wild-type) mice. B. Quantiation of experiment with 4 week 25 old mice. C. Quantiation of experiment with 3 week old mice DETAILED DESCRIPTION OF THE INVENTION -6- [00039] The present invention provides methods of treating baldness in a subject and generating new HF, comprising epidermal disruption and administration of a compound that promotes a differentiation of an uncommitted epidermal cell into a hair follicle cell. The present invention also provides methods for hair removal and inducing hair pigmentation. 5 [00040] In one embodiment, the present invention provides a method for generating a hair follicle (HF) in a scalp, eyebrow, or scarred region of a subject, comprising the steps of: (a) disrupting an epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, or scarred region with a compound that promotes a differentiation of an uncommitted epidermal cell into an HF cell, thereby generating an HF in a scalp, eyebrow, or scarred region of a subject. 10 [00041] In another embodiment, the present invention provides a method for generating an HF in a scalp, eyebrow, or scarred region of a subject, comprising the steps of: (a) disrupting an epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, or scarred region with a factor that promotes a differentiation of an uncommitted epidermal cell into an HF cell, thereby generating an HF in a scalp, eyebrow, or scarred region of a subject. 15 [00042] In another embodiment, the present invention provides a method for generating a new HF in a scalp, eyebrow, or scarred region of a subject, comprising the steps of: (a) disrupting an epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, or scarred region with a compound or factor that promotes a differentiation of an uncommitted epidermal cell into a hair follicle cell, thereby generating a new HF in a scalp, eyebrow, or scarred region of a subject. 20 [00043] In another embodiment, the present invention provides a method for increasing the number of HF in a scalp, eyebrow, or scarred region of a subject, comprising the steps of: (a) disrupting an epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, or scarred region with a compound or factor that promotes a differentiation of an uncommitted epidermal cell into an HF cell, thereby increasing the number of HF in a scalp, eyebrow, or scarred region of a 25 subject. [00044] In another embodiment, the present invention provides a use of a compound or factor that promotes a differentiation of an uncommitted epidermal cell into an HF cell, for the preparation of a -7pharmaceutical composition for use in a method for generating a hair follicle in a scalp, eyebrow, or scarred region of a subject, the method comprising the steps of: (a) disrupting an epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, or scarred region with the compound or factor. 5 [00045] In another embodiment, the present invention provides a use of a compound or factor that promotes a differentiation of an uncommitted epidermal cell into an HF cell, for the preparation of a pharmaceutical composition for use in a method for treating baldness in a scalp, eyebrow, or scarred region of a subject, the method comprising the steps of: (a) disrupting an epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, or scarred region with the 10 compound or factor. [00046] In another embodiment, the present invention provides a use of a compound or factor that promotes a differentiation of an uncommitted epidermal cell into an HF cell, for the preparation of a pharmaceutical composition for use in a method for treating AGA in a scalp of a subject, the method comprising the steps of: (a) disrupting an epidermis of the scalp, eyebrow, or scarred region; and (b) 15 contacting the scalp with the compound or factor. [00047] In another embodiment, the present invention provides a method for increasing a size of a hair follicle in a scalp, eyebrow, or scarred region of a subject, the method comprising the steps of: (a) disrupting an epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, or scarred region with a compound or factor that promotes a differentiation of an 20 uncommitted epidermal cell into an HF cell, thereby increasing a size of a hair follicle in a scalp, eyebrow, or scarred region of a subject. In another embodiment, the factor is an inhibitor of an EGF protein or an EGFR. In another embodiment, the factor is a Hedgehog protein, a nucleotide encoding same or an activator of same. In another embodiment, the factor is an androgen antagonist. In another embodiment, the factor is any other compound or factor that promotes a differentiation of an 2 5 uncommitted epidermal cell into an HF cell. Each possibility represents a separate embodiment of the present invention. [00048] In another embodiment, the present invention provides a method for generating a hair follicle in a scalp, eyebrow, or scarred region of a subject, comprising the steps of: (a) disrupting an -8epidermis of said scalp, eyebrow, or scarred region; and (b) contacting said scalp, eyebrow, or scarred region with a cell selected from (a) a precursor cell that is capable of differentiation into a hair follicle cell; (b) an inductive cell that is capable of inducing differentiation of an uncommitted epidermal cell into a hair follicle cell; or (c) a hair follicle or portion thereof, thereby generating a 5 hair follicle in a scalp, eyebrow, or scarred region of a subject. In another embodiment, step (b) is performed 3-12 days after step (a). Each possibility represents a separate embodiment of the present invention. [00049] The precursor cell of methods and compositions of the present invention, is, in another embodiment, a HF stem cell. In another embodiment, the precursor cell is an epidermal cell. In 10 another embodiment, the precursor cell is a dermal papilla cell. In another embodiment, the precursor cell is a connective tissue sheath cell. In another embodiment, the precursor cell is any other type of cell known in the art that is capable of differentiation into a hair follicle cell. Each possibility represents a separate embodiment of the present invention. [00050] In another embodiment, the present invention provides a method for generating a hair 15 follicle in a scalp, eyebrow, or scarred region of a subject, comprising the steps of: (a) disrupting an epidermis of said scalp, eyebrow, or scarred region; and (b) contacting said scalp, eyebrow, or scarred region with a precursor cell that is capable of differentiation into a hair follicle cell, thereby generating a hair follicle in a scalp, eyebrow, or scarred region of a subject. [00051] In another embodiment, the present invention provides a method for treating an AGA in a 20 scalp, comprising the steps of: (a) disrupting an epidermis of said scalp; and (b) contacting said scalp with a cell selected from (a) a precursor cell that is capable of differentiation into a hair follicle cell; (b) an inductive cell that is capable of inducing differentiation of an uncommitted epidermal cell into a hair follicle cell; or (c) a hair follicle or portion thereof, thereby treating an AGA in a scalp. In another embodiment, step (b) is performed 3-12 days after step (a). Each possibility 2 5 represents a separate embodiment of the present invention. [00052] In another embodiment, the present invention provides a method for treating an AGA in a scalp, comprising the steps of: (a) disrupting an epidermis of said scalp; and (b) contacting said -9scalp with a precursor cell that is capable of differentiation into a hair follicle cell, thereby treating an AGA in a scalp. [00053] In another embodiment, the inductive cell is a mesenchymal cell. In another embodiment, the inductive cell is any other type of inductive cell enumerated herein. In another embodiment, the 5 inductive cell is any other type of inductive cell known in the art. Each possibility represents a separate embodiment of the present invention. [00054] "Contacting" as used herein refers, in another embodiment, to bringing the scalp, eyebrow, etc, into to contact with the compound, factor, cell, etc. In another embodiment, the term refers to embedding the compound, factor, cell, etc into the scalp, eyebrow, etc. In another embodiment, the 10 term refers to injecting the compound, factor, cell, etc into the scalp, eyebrow, etc. In another embodiment, term refers to any other type of contacting known in the art. Each possibility represents a separate embodiment of the present invention. [00055] "Promotes a differentiation" refers, in another embodiment, to the act of increasing the percentage of cells that will differentiate as indicated. In another embodiment, the term refers to 15 increasing the number of cells per unit area of skin that will differentiate. In anotherembodiment, the promoter of differentiation is active in the milieu of the skin. Each possibility represents a separate embodiment of the present invention. [00056] "Uncommitted epidermal cell" refers, in another embodiment, to an epidermal stem cell. In another embodiment, the epidermal cell is a bulge cell. In another embodiment, the epidermal cell is 2 0 a bulge-derived cell. In another embodiment, the epidermal cell is any other type of cell known in the art that can be induced to differentiate into an HF cell. [00057] The "HF cell" that results from the diffentiation is, in another embodiment, an HF stem cell. In another embodiment, the HF cell is a dermal papilla cell. In another embodiment, the HF cell is a bulb cell. In another embodiment, the HF cell is a matrix cell. In another embodiment, the HF cell is 25 a hair shaft cell. In another embodiment, the HF cell is an inner root sheath cell. In another embodiment, the HF cell is an outer root sheath cell. In another embodiment, the HF cell is a - 10melanocyte stem cell. In another embodiment, the HF cell is a melanocyte. Each type of uncommitted epidermal cell and HF cell represents a separate embodiment of the present invention. [00058] In another embodiment, the present invention provides a method for treating baldness in a scalp, eyebrow, or scarred region, comprising the steps of: (a) disrupting an epidermis of the scalp, 5 eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, or scarred region with a compound that promotes a differentiation of an uncommitted epidermal cell into a hair follicle (HF) cell, thereby treating baldness in a scalp, eyebrow, or scarred region. In another embodiment, the baldness is an androgenetic alopecia (AGA)-induced baldness. Each possibility represents a separate embodiment of the present invention. 10 [00059] In another embodiment, the present invention provides a method for treating baldness in a scalp, eyebrow, or scarred region, comprising the steps of: (a) disrupting an epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, or scarred region with a factor that promotes a differentiation of an uncommitted epidermal cell into a HF cell, thereby treating baldness in a scalp, eyebrow, or scarred region. In another embodiment, the baldness is an 15 androgenetic alopecia (AGA)-induced baldness. Each possibility represents a separate embodiment of the present invention. [00060] In another embodiment, the compound or factor that promotes a differentiation of an uncommitted epidermal cell into a HF cell is administed in a solution. In another embodiment, the compound or factor is administed in a cream. In another embodiment, the compound or factor is 20 administed in an ointment. In another embodiment, the compound or factor is administed in a slow release formulation. In another embodiment, the compound or factor is administed in a liposome encapsulated formulation. In another embodiment, the compound or factor is directly injected. In another embodiment, the compound or factor is administed by any other method known in the art. Each possibility represents a separate embodiment of the present invention. 2 5 [00061] The compound or factor that promotes a differentiation of an uncommitted epidermal cell into a HF cell is, in another embodiment, an inhibitor of an Epidermal Growth Factor (EGF). In another embodiment, the compound or factor is an inhibitor of an EGF receptor. Each possibility represents a separate embodiment of the present invention. - 11 - [00062] As provided herein (Example 11), activating one or more pathways in which EGF is involved (by injection of EGF) blocks the formation of HF. Thus, antagonizing the pathway increases HF formation, as demonstrated in Example 12. [00063] In another embodiment, the inhibitor of an EGF or an EGF receptor is panitumumab. In 5 another embodiment, the inhibitor is AG1478. In another embodiment, the inhibitor is nimotuzumab. In another embodiment, the inhibitor is an antibody that binds EGF or EGFR. In another embodiment, the inhibitor is HuMax-EGFR@ (Genmab, Copenhagen, Denmark). In another embodiment, the inhibitor is cetuximab. In another embodiment, the inhibitor is IMC 11F8. In another embodiment, the inhibitor is matuzumab. In another embodiment, the inhibitor is SC 100. In 10 another embodiment, the inhibitor is ALT 110. In another embodiment, the inhibitor is PX 1032. In another embodiment, the inhibitor is BMS 599626. In another embodiment, the inhibitor is MDX 214. In another embodiment, the inhibitor is PX 1041. In another embodiment, the inhibitor is any other inhibitor of an EGF or an EGF receptor known in the art. Each possibility represents a separate embodiment of the present invention. 15 [00064] In another embodiment, the compound or factor that promotes a differentiation of an uncommitted epidermal cell into a HF cell is an inhibitor of a tyrosine kinase activity of an EGF receptor. In another embodiment, the inhibitor is gefitinib. In another embodiment, the inhibitor is erlotinib. In another embodiment, the inhibitor is canertinib. In another embodiment, the inhibitor is leflunomide. In another embodiment, the inhibitor is A77 1726. In another embodiment, the 2 0 inhibitor is pelitinib. In another embodiment, the inhibitor is ZD 1839. In another embodiment, the inhibitor is CL 387785. In another embodiment, the inhibitor is EKI 785. In another embodiment, the inhibitor is vandetanib. In another embodiment, the inhibitor is any other inhibitor of a tyrosine kinase activity of an EGF receptor known in the art. Each possibility represents a separate embodiment of the present invention. 25 [00065] In another embodiment, the EGF or EGFR antagonist is a carboxypeptidase inhibitor from potato (PCI) protein or a homologue, fragment or mimetic thereof. In another embodiment, the EGF or EGFR antagonist is a sprouty protein or a homologue, fragment or mimetic thereof. In another embodiment, the EGF or EGFR antagonist is an Argos protein or a homologue, fragment or mimetic - 12 thereof In another embodiment, the EGF or EGFR antagonist is a lefty protein or a homologue, fragment or mimetic thereof In another embodiment, the EGF or EGFR antagonist is an antibody that recognizes EGF or EGFR, or a fragment or mimetic thereof In another embodiment, the EGF or EGFR antagonist is small molecule inhibitor that binds and reduces the activity of EGF or EGFR. In 5 another embodiment, the EGF or EGFR antagonist is CRM197. In another embodiment, the EGF or EGFR antagonist is IMC-C225 (ImClone Systems, New York, NY). In another embodiment, the EGF or EGFR antagonist is any other antagonist of EGF or EGFR known in the art. Each possibility represents a separate embodiment of the present invention. [00066] In another embodiment, the present invention provides a use of an inhibitor of an EGF 10 protein or an EGF receptor for the preparation of a pharmaceutical composition for use in a method for generating a hair follicle in a scalp, eyebrow, or scarred region of a subject, the method comprising the steps of: (a) disrupting an epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, or scarred region with the inhibitor of an EGF protein or an EGF receptor. 15 [00067] In another embodiment, the present invention provides a use of an inhibitor of an EGF protein or an EGF receptor for the preparation of a pharmaceutical composition for use in a method for treating baldness in a scalp, eyebrow, or scarred region of a subject, the method comprising the steps of: (a) disrupting an epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, or scarred region with the inhibitor of an EGF protein or an EGF receptor. 20 [00068] In another embodiment, the present invention provides a use of an inhibitor of an EGF protein or an EGF receptor for the preparation of a pharmaceutical composition for use in a method for treating AGA in a scalp of a subject, the method comprising the steps of: (a) disrupting an epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp with the inhibitor of an EGF protein or an EGF receptor. 25 [00069] In another embodiment, the compound or factor that promotes a differentiation of an uncommitted epidermal cell into a HF cell is a B-catenin protein. In another embodiment, the compound or factor is a nucleotide that encodes a B-catenin protein. In another embodiment, the compound or factor is an activator of a B-catenin protein. In another embodiment, the compound or - 13 factor is an inhibitor of a protein that suppresses an activity of the B-catenin protein. Each possibility represents a separate embodiment of the present invention. [00070] In another embodiment, the present invention provides a use of (a) a B-catenin protein; (b) a nucleotide encoding a B-catenin protein; or (c) a compound or factor that activates a B-catenin 5 protein, for the preparation of a pharmaceutical composition for use in a method for generating a hair follicle in a scalp, eyebrow, or scarred region of a subject, the method comprising the steps of: (a) disrupting an epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, or scarred region with the B-catenin protein, nucleotide, compound or factor. [00071] In another embodiment, the present invention provides a use of (a) a B-catenin protein; (b) a 10 nucleotide encoding a B-catenin protein; or (c) a compound or factor that activates a B-catenin protein, for the preparation of a pharmaceutical composition for use in a method for treating baldness in a scalp, eyebrow, or scarred region of a subject, the method comprising the steps of: (a) disrupting an epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, or scarred region with the B-catenin protein, nucleotide, compound or factor. 15 [00072] In another embodiment, the present invention provides a use of (a) a B-catenin protein; (b) a nucleotide encoding a B-catenin protein; or (c) a compound or factor that activates a B-catenin protein, for the preparation of a pharmaceutical composition for use in a method for treating AGA in a scalp of a subject, the method comprising the steps of: (a) disrupting an epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp with the B-catenin protein, nucleotide, 20 compound or factor. [00073] In another embodiment, the compound or factor that promotes a differentiation of an uncommitted epidermal cell into a HF cell is a fibroblast growth factor (FGF) protein. In another embodiment, the compound or factor is a nucleotide that encodes an FGF protein. In another embodiment, the compound or factor is an FGF receptor. In another embodiment, the compound or 2 5 factor is a nucleotide that encodes an FGF receptor. In another embodiment, the compound or factor is an activator of an FGF protein. In another embodiment, the compound or factor is an activator of FGF receptor. In another embodiment, the compound or factor is an inhibitor of a protein that suppresses an activity of the FGF protein or FGF receptor. In another embodiment, the protein that - 14 is inhibited is an FGF binding protein. In another embodiment, the protein that is inhibited is FGF bp . Each possibility represents a separate embodiment of the present invention. [00074] Is provided herein, FGF and its receptor are upregulated, under the conditions utilized herein, upon HF stem cell differentiation (Example 9). Moreover, FGF-bp1 is downregulated, under 5 the conditions utilized herein, upon HF stem cell differentiation. Thus, FGF and its receptor promote differentiation of uncommitted epidermal cells into HF cells. [00075] In another embodiment, the compound or factor that promotes a differentiation of an uncommitted epidermal cell into a HF cell is an ectodysplasin protein (referred to, in another embodiment, as "eda"; in another embodiment, as "ectodermodysplasin protein.") In another 10 embodiment, the ectodysplasin protein is Eda-A1. In another embodiment, the compound or factor is an ectodysplasin receptor (referred to, in another embodiment, as "edar"). In another embodiment, the compound or factor is an activator of an ectodysplasin protein. In another embodiment, the compound or factor is an activator of an ectodysplasin receptor. In another embodiment, the compound or factor is an inhibitor of a protein that suppresses an activity of the ectodysplasin 15 protein or ectodysplasin receptor. Each possibility represents a separate embodiment of the present invention. [00076] In another embodiment, the eda protein of methods and compositions of the present invention has the sequence: MGYPEVERRELLPAAAPRERGSQGCGCGGAPARAGEGNSCLLFLGFFGLSLALHLLTLCC 20 YLELRSELRRERGAESRLGGSGTPGTSGTLSSLGGLDPDSPITSHLGQPSPKQQPLEPGEAAL HSDSQDGHQMALLNFFFPDEKPYSEEESRRVRRNKRSKSNEGADGPVKNKKKGKKAGPP GPNGPPGPPGPPGPQGPPGIPGIPGIPGTTVMGPPGPPGPPGPQGPPGLQGPSGAADKAGTR ENQPAVVHLQGQGSAIQVKNDLSGGVLNDWSRITMNPKVFKLHPRSGELEVLVDGTYFIY SQVEVYYINFTDFASYEVVVDEKPFLQCTRSIETGKTNYNTCYTAGVCLLKARQKIAVKM 25 VHADISINMSKHTTFFGAIRLGEAPAS (GenBank Accession No: NM_001399; SEQ ID No: 274). In another embodiment, the eda protein has a sequence selected from the sequences set forth in GenBank entries NM_001005609, NM_001005610, NM_001005611, NM_001005612, NM_001005613, NM_001005614, NM_001005615, AF040628, AF061194, AF061193, -15- AF061192, AF061191, AF061190, AF061189, and AF060999. In another embodiment, the eda protein is encoded by a nucleic acid molecule having a sequence set forth in the one of the above GenBank entries. In another embodiment, a biologically active fragment of an Eda protein is utilized in a method of the present invention. Each possibility represents a separate embodiment of 5 the present invention. [00077] In another embodiment, the edar protein of methods and compositions of the present invention has the sequence: MAHVGDCTQTPWLPVLVVSLMCSARAEYSNCGENEYYNQTTGLCQECPPCGPGEEPYLS CGYGTKDEDYGCVPCPAEKFSKGGYQICRRHKDCEGFFRATVLTPGDMENDAECGPCLP 10 GYYMLENRPRNIYGMVCYSCLLAPPNTKECVGATSGASANFPGTSGSSTLSPFQHAHKELS GQGHLATALIIAMSTIFIMAIAIVLIIMFYILKTKPSAPACCTSHPGKSVEAQVSKDEEKKEAP DNVVMFSEKDEFEKLTATPAKPTKSENDASSENEQLLSRSVDSDEEPAPDKQGSPELCLLS LVHLAREKSATSNKSAGIQSRRKKILDVYANVCGVVEGLSPTELPFDCLEKTSRMLSSTYN SEKAVVKTWRHLAESFGLKRDEIGGMTDGMQLFDRISTAGYSIPELLTKLVQIERLDAVES 15 LCADILEWAGVVPPASQPHAAS (GenBank Accession No: BC093872; SEQ ID No: 275). In another embodiment, the edar protein has a sequence selected from the sequences set forth in GenBank entries BC093870; BC034919; NM_021783; NM_022336; AY152724; AF298812; AH008077; AF130996; AF130988. In another embodiment, the edar protein is encoded by a nucleic acid molecule having a sequence set forth in the one of the above GenBank entries. In 2 0 another embodiment, a biologically active fragment of an Edar protein is utilized in a method of the present invention. Each possibility represents a separate embodiment of the present invention. [00078] In another embodiment, the compound or factor that promotes a differentiation of an uncommitted epidermal cell into a HF cell is a Noggin protein. In another embodiment, the compound or factor is a nucleotide encoding a Noggin protein. In another embodiment, the 25 compound or factor is an activator of a Noggin protein. In another embodiment, the compound or factor is an inhibitor of a protein that suppresses an activity of the Noggin protein. Each possibility represents a separate embodiment of the present invention. - 16- [00079] In another embodiment, the Noggin protein of methods and compositions of the present invention has the sequence: MERCPSLGVTLYALVVVLGLRATPAGGQHYLHIRPAPSDNLPLVDLIEHPDPIFDPKEKDLNE TLLRSLLGGHYDPGFMATSPPEDRPGGGGGAAGGAEDLAELDQLLRQRPSGAMPSEIKGLE 5 FSEGLAQGKKQRLSKKLRRKLQMWLWSQTFCPVLYAWNDLGSRFWPRYVKVGSCFSKRS CSVPEGMVCKPSKSVHLTVLRWRCQRRGGQRCGWIPIQYPIISECKCSC (GenBank Accession No: NM_005450; SEQ ID No: 276). In another embodiment, the Noggin protein has a sequence selected from the sequences set forth in GenBank entries BC034027 and U31202. In another embodiment, the Noggin protein is encoded by a nucleic acid molecule having a sequence set forth 10 in the one of the above GenBank entries. In another embodiment, a biologically active fragment of a Noggin protein is utilized in a method of the present invention. Each possibility represents a separate embodiment of the present invention. [00080] In another embodiment, the compound or factor that promotes a differentiation of an uncommitted epidermal cell into a HF cell is a Hedgehog protein. In another embodiment, the 15 compound or factor is a nucleotide encoding a Hedgehog protein. In another embodiment, the compound or factor is an activator of a Hedgehog protein. In another embodiment, the compound or factor is a sonic Hedgehog protein. In another embodiment, the compound or factor is a nucleotide encoding a sonic Hedgehog protein. In another embodiment, the compound or factor is an activator of a sonic Hedgehog protein. Each possibility represents a separate embodiment of the present 20 invention. [00081] In another embodiment, the Hedgehog protein of methods and compositions of the present invention has the sequence set forth in GenBank Accession No. NM_000193. In another embodiment, the Hedgehog protein has a sequence selected from those set forth in GenBank entries L3 8518 and NP_000184. In another embodiment, the Hedgehog protein has any other Hedgehog 25 sequence known in the art. In another embodiment, the Hedgehog protein has any other sonic Hedgehog sequence known in the art. Each possibility represents a separate embodiment of the present invention. - 17- [00082] In another embodiment, the compound or factor that promotes a differentiation of an uncommitted epidermal cell into a HF cell is a Transforming Growth Factor (TGF)-betal protein. In another embodiment, the compound or factor is a nucleotide encoding a TGF-betal protein. In another embodiment, the compound or factor is an activator of a TGF-betal protein. In another 5 embodiment, the compound or factor is a TGF-beta3 protein. In another embodiment, the compound or factor is a nucleotide encoding a TGF-beta3 protein. In another embodiment, the compound or factor is an activator of a TGF-beta3 protein. In another embodiment, the compound or factor is an antagonist of a TGF-betal protein. In another embodiment, the compound or factor is an antagonist of a TGF-beta3 protein. Each possibility represents a separate embodiment of the present invention. 10 [00083] In another embodiment, the TGF-betal protein of methods and compositions of the present invention has the sequence set forth in GenBank Accession No. BC000125. In another embodiment, the Hedgehog protein has a sequence selected from those set forth in GenBank entries BC001180, BC022242, and NM_000660. In another embodiment, the TGF-betal protein has any other TGF betal sequence known in the art. Each possibility represents a separate embodiment of the present 15 invention. [00084] In another embodiment, the TGF-beta3 protein of methods and compositions of the present invention has the sequence set forth in GenBank Accession No. J03241. In another embodiment, the Hedgehog protein has a sequence selected from those set forth in GenBank entries NM_003239, BC018503, BT007287 and X14149. In another embodiment, the TGF-beta3 protein has any other 20 TGF-beta3 sequence known in the art. Each possibility represents a separate embodiment of the present invention. [00085] In another embodiment, the compound or factor that promotes a differentiation of an uncommitted epidermal cell into a HF cell acts directly on the uncommitted epidermal cell. In another embodiment, the compound or factor acts on the uncommitted epidermal cell via a 25 mesenchymal cell. Each possibility represents a separate embodiment of the present invention. [00086] In another embodiment, the mesenchymal cell is a dermal condensate cell. In another embodiment, the mesenchymal cell is a DP cell. In another embodiment, the mesenchymal cell is another cell type or differentiation stage in the dermal condensate-DP lineage. In another - 18embodiment, the mesenchymal cell is any other type of mesenchymal cell known in the art. Each possibility represents a separate embodiment of the present invention. [00087] The EGFR of methods and compositions of the present invention has, in another embodiment, the sequence: 5 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEV VLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVL SNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQN HLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTG PRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVV 10 TDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKN CTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEII RGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKT KIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREF VENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWK 15 YADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMR RRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLW IPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMP FGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKI TDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGS 20 KPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQ RYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSPSTSRTPLLSS LSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLPVPEYINQSVPKR PAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCVNSTFDSPAHWAQ KGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEFIGA (GenBank 25 Accession No: NM_005228; SEQ ID No: 277). In another embodiment, the EGFR has a sequence selected from the sequences set forth in GenBank entries NM_201282, NM_201283, NM_201284, BC094761, AF288738, AY588246, AY573061, X17054, AF125253, U48722, K03193, and AY698024. In another embodiment, the EGFR is encoded by a nucleic acid molecule having a sequence set forth in the one of the above GenBank entries. In another embodiment, a biologically - 19active fragment of an EGFR is utilized in a method of the present invention. Each possibility represents a separate embodiment of the present invention. [00088] The EGF of methods and compositions of the present invention has, in another embodiment, the sequence: 5 MLLTLIILLPVVSKFSFVSLSAPQHWSCPEGTLAGNGNSTCVGPAPFLIFSHGNSIFRIDTEGTN YEQLVVDAGVSVIMDFHYNEKRIYWVDLERQLLQRVFLNGSRQERVCNIEKNVSGMAINW INEEVIWSNQQEGIITVTDMKGNNSHILLSALKYPANVAVDPVERFIFWSSEVAGSLYRADL DGVGVKALLETSEKITAVSLDVLDKRLFWIQYNREGSNSLICSCDYDGGSVHISKHPTQHNL FAMSLFGDRIFYSTWKMKTIWIANKHTGKDMVRINLHSSFVPLGELKVVHPLAQPKAEDDT 10 WEPEQKLCKLRKGNCSSTVCGQDLQSHLCMCAEGYALSRDRKYCEDVNECAFWNHGCTL GCKNTPGSYYCTCPVGFVLLPDGKRCHQLVSCPRNVSECSHDCVLTSEGPLCFCPEGSVLER DGKTCSGCSSPDNGGCSQLCVPLSPVSWECDCFPGYDLQLDEKSCAASGPQPFLLFANSQDI RHMHFDGTDYGTLLSQQMGMVYALDHDPVENKIYFAHTALKWIERANMDGSQRERLIEE GVDVPEGLAVDWIGRRFYWTDRGKSLIGRSDLNGKRSKIITKENISQPRGIAVHPMAKRLFW 15 TDTGINPRIESSSLQGLGRLVIASSDLIWPSGITIDFLTDKLYWCDAKQSVIEMANLDGSKRRR LTQNDVGHPFAVAVFEDYVWFSDWAMPSVIRVNKRTGKDRVRLQGSMLKPSSLVVVHPL AKPGADPCLYQNGGCEHICKKRLGTAWCSCREGFMKASDGKTCLALDGHQLLAGGEVDL KNQVTPLDILSKTRVSEDNITESQHMLVAEIMVSDQDDCAPVGCSMYARCISEGEDATCQC LKGFAGDGKLCSDIDECEMGVPVCPPASSKCINTEGGYVCRCSEGYQGDGIHCLDIDECQLG 20 VHSCGENASCTNTEGGYTCMCAGRLSEPGLICPDSTPPPHLREDDHHYSVRNSDSECPLSHD GYCLHDGVCMYIEALDKYACNCVVGYIGERCQYRDLKWWELRHAGHGQQQKVIVVAVC VVVLVMLLLLSLWGAHYYRTQKLLSKNPKNPYEESSRDVRSRRPADTEDGMSSCPQPWFV VIKEHQDLKNGGQPVAGEDGQAADGSMQPTSWRQEPQLCGMGTEQGCWIPVSSDKGSCP QVMERSFHMPSYGTQTLEGGVEKPHSLLSANPLWQQRALDPPHQMELTQ (GenBank 25 Accession No: NM_001963; SEQ ID No: 278). In another embodiment, the EGF has a sequence selected from the sequences set forth in GenBank entries BC093731, AY548762, and X04571. In another embodiment, the EGF is encoded by a nucleic acid molecule having a sequence set forth in the one of the above GenBank entries. In another embodiment, a biologically active fragment of an - 20 - EGF is utilized in a method of the present invention. Each possibility represents a separate embodiment of the present invention. [00089] The beta-catenin protein of methods and compositions of the present invention has, in another embodiment, the sequence: 5 MATQADLMELDMAMEPDRKAAVSHWQQQSYLDSGIHSGATTTAPSLSGKGNPEEEDVDT SQVLYEWEQGFSQSFTQEQVADIDGQYAMTRAQRVRAAMFPETLDEGMQIPSTQFDAAHP TNVQRLAEPSQMLKHAVVNLINYQDDAELATRAIPELTKLLNDEDQVVVNKAAVMVHQLS KKEASRHAIMRSPQMVSAIVRTMQNTNDVETARCTAGTLHNLSHHREGLLAIFKSGGIPAL VKMLGSPVDSVLFYAITTLHNLLLHQEGAKMAVRLAGGLQKMVALLNKTNVKFLAITTDC 10 LQILAYGNQESKLIILASGGPQALVNIMRTYTYEKLLWTTSRVLKVLSVCSSNKPAIVEAGG MQALGLHLTDPSQRLVQNCLWTLRNLSDAATKQEGMEGLLGTLVQLLGSDDINVVTCAAG ILSNLTCNNYKNKMMVCQVGGIEALVRTVLRAGDREDITEPAICALRHLTSRHQEAEMAQN AVRLHYGLPVVVKLLHPPSHWPLIKATVGLIRNLALCPANHAPLREQGAIPRLVQLLVRAHQ DTQRRTSMGGTQQQFVEGVRMEEIVEGCTGALHILARDVHNRIVIRGLNTIPLFVQLLYSPIE 15 NIQRVAAGVLCELAQDKEAAEAIEAEGATAPLTELLHSRNEGVATYAAAVLFRMSEDKPQD YKKRLSVELTSSLFRTEPMAWNETADLGLDIGAQGEPLGYRQDDPSYRSFHSGGYGQDALG MDPMMEHEMGGHHPGADYPVDGLPDLGHAQDLMDGLPPGDSNQLAWFDTDL (GenBank Accession No: NM_001904; SEQ ID No: 279). In another embodiment, the beta-catenin protein has a sequence selected from the sequences set forth in GenBank entries BC058926, X87838, 20 AF130085, AB062292, Z19054, and NP_001895. In another embodiment, the beta-catenin protein is encoded by a nucleic acid molecule having a sequence set forth in the one of the above GenBank entries. In another embodiment, a biologically active fragment of a beta-catenin protein is utilized in a method of the present invention. Each possibility represents a separate embodiment of the present invention. 25 [00090] The Wnt protein of methods and compositions of the present invention has, in another embodiment, the sequence: MNRKARRCLGHLFLSLGMVYLRIGGFSSVVALGASIICNKIPGLAPRQRAICQSRPDAIIVIGE GSQMGLDECQFQFRNGRWNCSALGERTVFGKELKVGSREAAFTYAIIAAGVAHAITAACT -21 - QGNLSDCGCDKEKQGQYHRDEGWKWGGCSADIRYGIGFAKVFVDAREIKQNARTLMNLH NNEAGRKILEENMKLECKCHGVSGSCTTKTCWTTLPQFRELGYVLKDKYNEAVHVEPVRA SRNKRPTFLKIKKPLSYRKPMDTDLVYIEKSPNYCEEDPVTGSVGTQGRACNKTAPQASGC DLMCCGRGYNTHQYARVWQCNCKFHWCCYVKCNTCSERTEMYTCK (GenBank Accession 5 No: BC0088 11; SEQ ID No: 280). In another embodiment, the Wnt protein has a sequence selected from the sequences set forth in GenBank entries NM_004625, D83175, U53476, and NP_004616. In another embodiment, the Wnt protein is a Wnt7 protein. In another embodiment, the Wnt protein is a Wnt7a protein. In another embodiment, the Wnt protein is Wntl protein. In another embodiment, the Wnt protein is a Wnt3 protein. In another embodiment, the Wnt protein is a Wnt3a 10 protein. In another embodiment, the Wnt protein is a Wnt10 protein. In another embodiment, the Wnt protein is a Wnt10a protein. In another embodiment, the Wnt protein is a Wnt Ob protein. In another embodiment, the Wnt protein is encoded by a nucleic acid molecule having a sequence set forth in the one of the above GenBank entries. In another embodiment, a biologically active fragment of a Wnt protein is utilized in a method of the present invention. In another embodiment, a 15 biologically active fragment of a Wnt7 protein is utilized in a method of the present invention. In another embodiment, a biologically active fragment of a Wnt7a protein is utilized in a method of the present invention. Each possibility represents a separate embodiment of the present invention. [00091] In another embodiment, the compound or factor that promotes a differentiation of an uncommitted epidermal cell into a HF cell is a protein encoded by a ribonucleic acid (RNA) 20 molecule having a sequence selected from the sequences set forth in SEQ ID No: 1-232. In another embodiment, the compound or factor is an RNA molecule having a sequence selected from SEQ ID No: 1-232. In another embodiment, the RNA molecule is homologous to a sequence selected from SEQ ID No: 1-232. In another embodiment, the RNA molecule is an isoform of a sequence selected from SEQ ID No: 1-232. In another embodiment, the compound or factor increases an activity of a 25 protein encoded by an RNA molecule having a sequence selected from SEQ ID No: 1-232. In another embodiment, the compound or factor increases an expression or level of a protein encoded by an RNA molecule having a sequence selected from SEQ ID No: 1-232. Each possibility represents a separate embodiment of the present invention. [00092] As provided herein, the transcripts depicted in Table 3 (Example 8; SEQ ID No: 1-232), the - 22 proteins they encode, and the pathways in which the proteins participate contribute significantly to HF stem cell activation. Accordingly, under the conditions utilized herein, anagen can be induced by activation of these transcripts, proteins, and pathways. Activation of the transcripts, proteins, and pathways depicted in Table 3 is thus a method for enhancing EDIHN. In another embodiment, 5 activation of these transcripts, proteins, and pathways represents a method for enhancing hair growth in a subject. [00093] In another embodiment, the compound or factor that promotes a differentiation of an uncommitted epidermal cell into a HF cell is a protein encoded by an RNA molecule having a sequence selected from the sequences set forth in SEQ ID No: 233-257. In another embodiment, the 10 compound or factor is an RNA molecule having a sequence selected from SEQ ID No: 233-257. In another embodiment, the RNA molecule is homologous to a sequence selected from SEQ ID No: 233-257. In another embodiment, the RNA molecule is an isoform of a sequence selected from SEQ ID No: 233-257. In another embodiment, the compound or factor increases an activity of a protein encoded by an RNA molecule having a sequence selected from SEQ ID No: 233-257. In another 15 embodiment, the compound or factor increases an expression or level of a protein encoded by an RNA molecule having a sequence selected from SEQ ID No: 233-257. Each possibility represents a separate embodiment of the present invention. [00094] As provided herein, the transcripts depicted in Table 4 (Example 9; SEQ ID No: 233-257), the proteins they encode, and the pathways in which the proteins participate, contribute significantly, 20 under the conditions utilized herein, to induction of epidermal cells to differentiate into HF stem cells. Activation of the transcripts, proteins, and pathways depicted in Table 4 is thus a method for enhancing EDIHN. In another embodiment, activation of these transcripts, proteins, and pathways represents a method for enhancing hair growth in a subject. [00095] In another embodiment, the compound or factor that promotes a differentiation of an 25 uncommitted epidermal cell into a HF cell is a compound or factor that decreases an activity of a protein encoded by an RNA molecule having a sequence selected from the sequences set forth in SEQ ID No: 258-273. In another embodiment, the compound or factor decreases an expression or - 23 level of a protein encoded by an RNA molecule having a sequence selected from SEQ ID No: 258 273. Each possibility represents a separate embodiment of the present invention. [00096] As demonstrated by findings of the present invention, the transcripts depicted in Table 5 (Example 9; SEQ ID No: 258-273), the proteins they encode, and the pathways in which the proteins 5 participate, contribute significantly, under the conditions utilized herein, to preventing induction of epidermal cells to differentiate into HF stem cells. Inhibition of the transcripts, proteins, and pathways depicted in Table 5 is thus a method for enhancing EDIHN. In another embodiment, inhibition of these transcripts, proteins, and pathways represents a method for induction of hair growth in a subject. 10 [00097] In one embodiment, the compound that modulates a protein encoded by an RNA molecule having a sequence selected from the sequences set forth in SEQ ID No: 233-273 or the nucleic acid encoding same is administered before the compound that modulates a protein encoded by an RNA molecule having a sequence selected from the sequences set forth in SEQ ID No: 1-232 or the nucleic acid encoding same. In another embodiment, the two compounds are administered 15 simultaneously. Each possibility represents a separate embodiment of the present invention. [00098] In one embodiment, a protein encoded by an RNA sequence selected from SEQ ID No: 1 273, or a compound that modulates the protein, is administered before other proteins encoded by same or compounds that modulate them, in order to further enhance their effect in generating an HF or stimulating hair growth. In another embodiment, the wnt pathway is stimulated before the 20 hedgehog pathway. In another embodiment, the two pathways are stimulated in an overlapping fashion. In another embodiment, the two pathways are stimulated simultaneously. Each possibility represents a separate embodiment of the present invention. [00099] In another embodiment, activating or decreasing expression of an RNA transcript in methods of the present invention occurs via a transcription mechanism (e.g. activation of expression 25 of the RNA). In another embodiment, activating or decreasing expression of the RNA transcript occurs via a translational mechanism. In another embodiment, activating or decreasing expression of the RNA transcript occurs via a post-translational mechanism. Each possibility represents a separate embodiment of the present invention. - 24 - [000100]In another embodiment, the nucleic acid molecule utilized in methods of the present invention is a deoxyribonucleic acid (DNA) molecule that encodes an RNA molecule having a sequence selected from the sequences set forth in the present invention. [000101 ]In one embodiment, an RNA molecule of the present invention encodes a protein that plays 5 a role in HF regeneration. In another embodiment, the RNA molecule is itself catalytically active, e.g., a ribozyme, etc. Each possibility represents a separate embodiment of the present invention. [000102] In another embodiment, the compound or factor that promotes a differentiation of an uncommitted epidermal cell into a HF cell is a compound or factor that promotes placodal cell fate. As provided herein, factors that promote placodal cell fate enhance EDIHN, as exemplified in the 10 Examples herein. In another embodiment, the compound or factor acts at the placode stage of HF development. [000103] In another embodiment, the compound or factor inhibits a biological factor that inhibits a differentiation of an uncommitted epithelial cell into an HF cell. [000104]In another embodiment of methods and compositions of the present invention, a 15 composition comprising one of the above compounds or factors is administered. Each of the above types of compounds, factors, and compositions represents a separate embodiment of the present invention. [000105] In one embodiment, the present invention provides a method for generating an HF in a scalp, eyebrow, or scarred region of a subject, comprising the steps of: (a) disrupting an epidermis of the 20 scalp, eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, or scarred region with minoxidil, thereby generating an HF in a scalp, eyebrow, or scarred region of a subject. [000106] In one embodiment, the present invention provides a method for treating baldness in a scalp, eyebrow, or scarred region of a subject, comprising the steps of: (a) disrupting an epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, or scarred region with 2 5 minoxidil, thereby treating baldness in a scalp, eyebrow, or scarred region of a subject. - 25 - [000107] In another embodiment, the present invention provides a use of minoxidil for the preparation of a pharmaceutical composition for use in a method for an HF in a scalp, eyebrow, or scarred region of a subject, the method comprising the steps of: (a) disrupting an epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, or scarred region with the 5 minoxidil. [000108] In another embodiment, the present invention provides a use of minoxidil for the preparation of a pharmaceutical composition for use in a method for treating baldness in a scalp, eyebrow, or scarred region of a subject, the method comprising the steps of: (a) disrupting an epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, or scarred region with the 10 minoxidil. [000109] In another embodiment, the present invention provides a method for removal of an HF from a skin or scalp of a subject, comprising the steps of: (a) disrupting an epidermis of the skin or scalp; and (b) contacting the skin or scalp with either: (i) an EGF protein; (ii) an EGF receptor; (iii) a nucleotide encoding an EGF protein or EGF receptor; or (iv) a compound or factor that activates a 15 EGF protein or EGF receptor, thereby removing an HF from a skin or scalp of a subject. [000110] In another embodiment, the present invention provides a method for hair removal from a skin or scalp of a subject, comprising the steps of: (a) disrupting an epidermis of the skin or scalp; and (b) contacting the skin or scalp with either: (i) an EGF protein; (ii) an EGF receptor; (iii) a nucleotide encoding an EGF protein or EGF receptor; or (iv) a compound or factor that activates a 20 EGF protein or EGF receptor, thereby removing hair from a skin or scalp of a subject. In another embodiment, the epidermal disruption is light dermabrasion. In another embodiment, the epidermal disruption is a non-scarring method. In another embodiment, administration of the EGF protein, EGF receptor, nucleotide, compound, or factor suppresses HF formation. In another embodiment, the EGF protein, EGF receptor, nucleotide, compound, or factor is administered within several days 25 of healing. In another embodiment, the EGF protein, EGF receptor, nucleotide, compound, or factor is administered within about 1 day of healing. In another embodiment, the EGF protein, EGF receptor, nucleotide, compound, or factor is administered according to any of the timing embodiments enumerated herein for Dkkl protein. Each possibility represents a separate -26 embodiment of the present invention. [000111] In another embodiment, the present invention provides a use of either: (i) an EGF protein; (ii) an EGF receptor; (iii) a nucleotide encoding an EGF protein or EGF receptor; or (iv) a compound or factor that activates a EGF protein or EGF receptor, for the preparation of a 5 pharmaceutical composition for use in a method for removal of an HF from a skin or scalp of a subject, the method comprising the steps of: (a) disrupting an epidermis of the scalp, eyebrow, or scarred region; and (b) contacting the scalp, eyebrow, or scarred region with the EGF protein, EGF receptor, nucleotide, compound, or factor. [000112] In another embodiment, a composition or method of the present invention is utilized on 10 human skin. In another embodiment, the composition or method is utilized on an area of unwanted hair growth. In another embodiment, the area is the face. In another embodiment, the area is the bikini area. In another embodiment, the area is the legs. In another embodiment, the area is the arms. In another embodiment, the area is the chest. [000113] An "inhibitor" utilized in methods and compositions of the present invention is, in another 15 embodiment, an antibody that binds the protein or biological factor that is the target of the inhibitor. In another embodiment, the inhibitor is a pharmacologic inhibitor. In another embodiment, the inhibitor is any other type of inhibitor known in the art. Each possibility represents a separate embodiment of the present invention. [000114] The step of disrupting the epidermis in methods of the present invention is performed, in 20 another embodiment, by abrading the scalp, eyebrow, or scarred region. In another embodiment, the term "abrading" refers to an act of creating an abrasion. In another embodiment, "abrading" refers to rubbing. In another embodiment, "abrading" refers to wearing away by friction. As provided herein (Example 1), epidermal abrasion causes, under the conditions utilized herein, de novo HF neo genesis. In another embodiment, the epidermal layer is disrupted. 25 [000115] In one embodiment, "abrasion" has the same meaning as "abrading." In another embodiment, "abrasion" refers to an area of the scalp or skin from which the epidermis is removed. In another embodiment, "abrasion" refers to an area of the scalp or skin from which the epidermis and dermis are removed. Each definition of "abrading" and "abrasion" represents a separate -27 embodiment of the present invention. [000116] As provided herein, under the conditions utilized, epidermal disruption by a method of the present invention converts the skin back, in another embodiment, to an embryonic-like state, in which the follicle regenerates. In another embodiment, a subsequent window of opportunity is 5 created, during which the number and size of new HF in the skin can be manipulated. In another embodiment, the administration of a compound or factor that promotes a differentiation of an uncommitted epidermal cell into a HF cell during this window causes regeneration of larger and more numerous HF. The morphology of HF in abraded skin is similar to that of embryonic HF (Example 1-2 and subsequent Examples), and the markers expressed are similar as well. 10 [000117] In another embodiment, the present invention provides a method of stimulating hair growth in a scalp, eyebrow, or scarred region of a subject, comprising performing a method of present invention, thereby stimulating hair growth in a scalp, eyebrow, or scarred region of a subject. As demonstrated in Example 3, EDIHN-induced HF are capable of generating hairs. Thus, methods of the present invention can be used to stimulate hair growth. 15 [000118] "EDIHN," in another embodiment, refers to HF neogenesis induced by disruption of the epithelial layer. In another embodiment, the term refers to HF neogenesis induced by abrasion. In another embodiment, the term refers to HF neogenesis induced by wounding. In another embodiment, the term refers to HF neogenesis induced by disruption of the epithelial layer, followed by administration of a compound or factor that promotes a differentiation of an uncommitted 20 epidermal cell into a HF cell. Each possibility represents a separate embodiment of the present invention. [000119] In another embodiment, the present invention provides a method of testing an ability of a compound to modulate HF generation in vivo, comprising (a) disrupting an epithelial layer of a first scalp, eyebrow, or scarred region, whereby the first scalp, eyebrow, or scarred region has been 25 contacted with the compound; (b) measuring a first HF generation in the first scalp, eyebrow, or scarred region; (c) disrupting an epithelial layer of a second scalp, eyebrow, or scarred region, wherein the second scalp, eyebrow, or scarred region is a scalp, eyebrow, or scarred region of the first subject or a second subject, whereby the second scalp, eyebrow, or scarred region has not been - 28 contacted with the compound; (d) measuring a second HF generation in the second scalp, eyebrow, or scarred region; and (e) comparing the first HF generation to the second HF generation, whereby a difference between the first HF generation and the second HF generation indicates that the compound modulates an HF generation in vivo (Examples). 5 [000120] In another embodiment, the present invention provides a method of testing an ability of a compound to stimulate hair growth in vivo, comprising disrupting an epithelial layer of a first scalp, eyebrow, or scarred region, whereby the first scalp, eyebrow, or scarred region has been contacted with the compound; measuring a first HF generation in the first scalp, eyebrow, or scarred region; disrupting an epithelial layer of a second scalp, eyebrow, or scarred region, whereby the second 10 scalp, eyebrow, or scarred region has not been contacted with the compound; measuring a second HF generation in the second scalp, eyebrow, or scarred region; and comparing the first HF generation to the second HF generation, whereby a difference between the first HF generation and the second HF generation indicates that the compound stimulates a hair growth in vivo. [000121 ]In one embodiment, the methods of the present invention of testing a compound are repeated 15 using a plurality of subjects, until a statistically significant sample has been tested. [000122] In another embodiment of methods for testing compounds of the present invention, the first scalp, eyebrow, or scarred region is a scalp, eyebrow, or scarred region of a first subject. In another embodiment, the subject is a subject in need of generation of a new HF. The second scalp, eyebrow, or scarred region, in another embodiment, is a scalp, eyebrow, or scarred region of the first subject. 2 0 In another embodiment, the second scalp, eyebrow, or scarred region is a scalp, eyebrow, or scarred region of a second subject. Each possibility represents a separate embodiment of the present invention. [000123]In another embodiment, the excisional wounds of methods of the present invention are created using a surgical tool. In one embodiment, the surgical tool is a dermal biopsy punch 25 (Example 2). In another embodiment, the excisional wounds are induced by freezing or cryoinjury. The use of freezing or cryoinjury is well known in the art, and is used, for example by dermatologists to injure skin. In one embodiment, the freezing or cryoinjury results in a blister. In another embodiment, the blister is used as a "chamber" to introduce drugs and or cells into the - 29 reepithelialized area. Each possibility represents a separate embodiment of the present invention. [000124] In another embodiment, the excisional wounds of methods of the present invention are not surgically closed. In another embodiment, the excisional wounds are not contacted with a bandage or dressing before they heal or during a period of time after wound induction. In another 5 embodiment, the excisional wounds are not contacted with an ointment before they heal or during a period of time after wound induction. In another embodiment, the excisional wounds are allowed to heal by secondary intention. Each possibility represents a separate embodiment of the present invention. [000125] The subject of methods of the present invention, is, in another embodiment, a human. As 10 provided herein (Example 7) human skin responds to EDIHN in the same manner as mouse skin. In another embodiment, the subject is a male. In another embodiment, the subject is a female. In another embodiment, the subject is any other type of subject known in the art. Each possibility represents a separate embodiment of the present invention. [000126] In another embodiment, the subject is an adult. In one embodiment, "adult" refers to an age 15 greater than about 18 years. In another embodiment, "adult" refers to an age greater than about 20 years. In another embodiment, "adult" refers to an age greater than about 25 years. In another embodiment, "adult" refers to an age greater than about 30 years. In another embodiment, "adult" refers to an age greater than about 35 years. In another embodiment, "adult" refers to an age greater than about 40 years. In another embodiment, "adult" refers to an age greater than about 45 years. 20 [000127] In another embodiment, the subject is elderly. In one embodiment, "elderly" refers to an age greater than about 45 years. In another embodiment, "elderly" refers to an age greater than about 50 years. In another embodiment, "elderly" refers to an age greater than about 55 years. In another embodiment, "elderly" refers to an age greater than about 60 years. In another embodiment, "elderly" refers to an age greater than about 65 years. In another embodiment, "elderly" refers to an 2 5 age greater than about 70 years. [000128] In another embodiment, the first subject, or, where applicable, both the first subject and the second subject, is a laboratory animal. In another embodiment, the subject(s) is/are mice. In another - 30 embodiment, the subject(s) is/are rats. In another embodiment, the subject(s) is/are gerbils. In another embodiment, the subject(s) is/are hamsters. In another embodiment, the subject(s) is/are guinea pigs. In another embodiment, the subject(s) is/are rabbits. In another embodiment, the subject(s) is/are pigs. In another embodiment, the subject(s) is/are dogs. In another embodiment, the 5 subject(s) is/are cats. In another embodiment, the subject(s) is/are primates. In another embodiment, the subject(s) is/are any other laboratory animal known in the art. Each possibility represents a separate embodiment of the present invention. [000129] In another embodiment, the subject(s) has a disease or disorder comprising balding. In another embodiment, the subject(s) does not have a disease or disorder comprising balding. In 10 another embodiment, the disease or disorder is androgenetic alopecia (AGA). In another embodiment, the disease or disorder is male pattern baldness. In another embodiment, the disease or disorder is female pattern baldness. In another embodiment, the disease or disorder is a discoid lupus erythematosis. In another embodiment, the disease or disorder is a congenital hypotrichosis. In another embodiment, the disease or disorder is a lichen planopilaris. In another embodiment, the 15 disease or disorder is a scarring alopecia. In another embodiment, the disease or disorder is any other disease or disorder comprising balding known in the art. [000130] In another embodiment, the scalp, eyebrow, or scarred region(s) has a majority of HF in the telogen stage of the hair cycle. The findings of Examples 5-6 show that (a) EDIHN can restore hair growth to the scalp, eyebrow, or scarred region at the telogen stage; and (b) the efficiency of EDIHN 20 at the telogen stage can be enhanced by depilation prior to abrasion or wound induction. In another embodiment, the scalp, eyebrow, or scarred region(s) has more than about 60% of HF in the telogen stage of the hair cycle. In another embodiment, the scalp, eyebrow, or scarred region(s) has more than about 70% of HF in the telogen stage of the hair cycle. In another embodiment, the scalp, eyebrow, or scarred region(s) has more than about 80% of HF in the telogen stage of the hair cycle. 2 5 In another embodiment, the scalp, eyebrow, or scarred region(s) has more than about 90% of HF in the telogen stage of the hair cycle. In another embodiment, the scalp, eyebrow, or scarred region(s) does not have a majority of HF in the telogen stage of the hair cycle. Each possibility represents a separate embodiment of the present invention. -31 - [000131 ]In another embodiment of methods and compositions of the present invention, the first step (e.g. epithelial disruption) is performed 3-12 days prior to the second step (e.g. addition of an active compound, factor, cell, etc). In another embodiment, the interval is 4-12 days. In another embodiment, the interval is 5-12 days. In another embodiment, the interval is 4-11 days. In another 5 embodiment, the interval is 6-11 days. In another embodiment, the interval is 6-10 days. In another embodiment, the interval is 6-9 days. In another embodiment, the interval is 6-8 days. In another embodiment, the interval is 7-8 days. In another embodiment, the interval is 5-11 days. In another embodiment, the interval is 5-10 days. In another embodiment, the interval is 7-10 days. In another embodiment, the interval is about 1 week. Each possibility represents a separate embodiment of the 10 present invention. [000132] In another embodiment, a method of the present invention further comprises the step of suppressing an activity or expression of a Wnt protein in the scalp, eyebrow, or scarred region. As provided herein, suppressing Wnt activity induces pigmentation in HF generated by methods of the present invention. In another embodiment, the step of suppressing Wnt activity or expression is 15 performed within about 10 days of epidermal disruption. In another embodiment, the step of suppressing Wnt activity or expression is performed prior to the second step (e.g prior to addition of a compound or factor that promotes HF cell differentiation. Each possibility represents a separate embodiment of the present invention. [000133] In another embodiment, the present invention provides a method for inducing pigmentation 20 of a hair, comprising suppressing expression of a Wnt protein in a follicle of the hair. In another embodiment, the Wnt protein is Wntl. In another embodiment, the Wnt protein is a Wnt7. In another embodiment, the Wnt protein is a Wnt7a. In another embodiment, the Wnt protein is a Wnt3. In another embodiment, the Wnt protein is a Wnt3a. In another embodiment, the Wnt protein is a Wnt10. In another embodiment, the Wnt protein is a Wnt Oa. In another embodiment, the Wnt 2 5 protein is any other Wnt protein known in the art. Each possibility represents a separate embodiment of the present invention. [000134] In another embodiment, the present invention provides a method for inducing growth of a pigmented scalp hair or eyebrow of a subject, comprising generating a hair follicle in the scalp, - 32 eyebrow, or scarred region according to a method of the present invention and suppressing expression of a Wnt protein in the hair follicle, thereby inducing a growth of a pigmented scalp hair or eyebrow of a subject. [000135] In another embodiment, the step of suppressing expression of a Wnt protein comprises 5 inducing an expression of a Dkkl protein. In another embodiment, the step of suppressing expression of a Wnt protein comprises inducing an expression of any other Wnt inhibitor known in the art. In another embodiment, the step of suppressing expression of a Wnt protein is performed immediately or shortly after epidermal disruption. In another embodiment, the step of inducing expression of a Dkkl protein is performed immediately or shortly after epidermal disruption. In 10 another embodiment, the step of suppressing expression of a Wnt protein is performed at the time of epidermal disruption. In another embodiment, the step of inducing expression of a Dkkl protein is performed at the time of epidermal disruption. In another embodiment, the step of suppressing expression of a Wnt protein is performed several days before generation of the follicle. In another embodiment, the step of inducing expression of a Dkkl protein several days before generation of the 15 follicle. Each possibility represents a separate embodiment of the present invention. [000136] In another embodiment, the step of suppressing expression of a Wnt protein is performed for about 8 days. In another embodiment, the step of inducing expression of a Dkkl protein is performed for about 8 days. In another embodiment, the step of suppressing expression of a Wnt protein is performed for about 9 days. In another embodiment, the step of inducing expression of a 20 Dkkl protein is performed for about 9 days. In another embodiment, the step of suppressing expression of a Wnt protein is performed for about 10 days. In another embodiment, the step of inducing expression of a Dkkl protein is performed for about 10 days. In another embodiment, the step of suppressing expression of a Wnt protein is performed for about 12 days. In another embodiment, the step of inducing expression of a Dkk1 protein is performed for about 12 days. In 25 another embodiment, the step of suppressing expression of a Wnt protein is performed during the period of re-epithelialization. In another embodiment, the step of inducing expression of a Dkk1 protein is performed during the period of re-epithelialization. In another embodiment, expression of a Dkk1 protein is halted after several days. In another embodiment, halting expression of Dkk1 protein after several days induces, or enables induction of Wnt protein expression. In another - 33 embodiment, the expression of a Wnt protein is induced about 9 days after the abrating or wounding. In another embodiment, the expression of a Wnt protein is induced following the period of re-epithelialization. In another embodiment, induction of Wnt protein expression is necessary for formation of new HF. Each possibility represents a separate embodiment of the present invention. 5 [000137] In another embodiment, "several" refers to about 1 day. In another embodiment, "several" refers to about 2 days. In another embodiment, "several" refers to about 3 days. In another embodiment, "several" refers to about 5 days. In another embodiment, "several" refers to about 7 days. In another embodiment, "several" refers to about 10 days. In another embodiment, "several" refers to about 12 days. Each possibility represents a separate embodiment of the present invention. 10 [000138] In another embodiment, the step of contacting in methods of the present invention comprises directly contacting the scalp, eyebrow, or scarred region with the compound, RNA, protein, etc. In another embodiment, the step of contacting comprises indirectly contacting the scalp, eyebrow, or scarred region via contacting another site or tissue of the subject, after which the compound, RNA, or protein is transported to the scalp, eyebrow, or scarred region by a biological process; e.g, 15 diffusion, active transport, or circulation in a fluid such as the blood, lymph, interstitial fluid, etc. Each possibility represents a separate embodiment of the present invention. [000139] In another embodiment, the epidermal disruption in methods of the present invention further removes dermal tissue from the scalp, eyebrow, or scarred region. In another embodiment, the epidermal disruption does not remove dermal tissue from the scalp, eyebrow, or scarred region. Each 2 0 possibility represents a separate embodiment of the present invention. [000140] "Disrupting" an epidermis or epidermal layer refers, in another embodiment, to removing part of the epidermis or epidermal layer. In another embodiment, the term refers to disturbing the intactness of the epidermis or epidermal layer. In another embodiment, the term refers to perforating the epidermis or epidermal layer. In another embodiment, only part of the the epidermal layer need 2 5 be removed. In another embodiment, the entire epidermal layer is removed. In another embodiment, the term refers to abrading the epidermis or epidermal layer (Examples). In another embodiment, the term refers to wounding the epidermis or epidermal layer (Examples). Each possibility represents a separate embodiment of the present invention. - 34 - [000141] In another embodiment, the epidermal disruption is performed with a tool that comprises sandpaper. In another embodiment, the epidermal disruption is performed with a laser. In another embodiment, the laser is a Fraxel laser. In another embodiment, the laser is a CO 2 laser. In another embodiment, the laser is an excimer laser. In another embodiment, the laser is any other type of laser 5 capable of inducing trans-epithelial injury. In another embodiment, the epidermal disruption is performed with a felt wheel. In another embodiment, the epidermal disruption is performed with a surgical tool. In another embodiment, the epidermal disruption is performed with any other tool known in the art that is capable of epidermal disruption. In another embodiment, the epidermal disruption comprises use of a micro-dermabrasion device. In another embodiment, the epidermal 10 disruption comprises a burn treatment. [000142] In another embodiment, the epidermal disruption comprises a disruption of a follicle of said epidermis and a disruption of an interfollicular region of said epidermis. In another embodiment, the epidermal disruption comprises a disruption of a follicle of said epidermis and does not comprise a disruption of an interfollicular region of said epidermis. Each possibility represents a separate 15 embodiment of the present invention. [000143] In another embodiment, the epidermal disruption comprises a light-based method. In another embodiment, the epidermal disruption comprises irradiation with visible light. In another embodiment, the epidermal disruption comprises irradiation with infrared light. In another embodiment, the epidermal disruption comprises irradiation with ultraviolet radiation. In another 20 embodiment, the epidermal disruption comprises orthovoltage irradiation. In another embodiment, the epidermal disruption comprises X-ray irradiation. In another embodiment, the epidermal disruption comprises any other type of irradiation known in the art. [000144] In another embodiment, the epidermal disruption is performed by mechanical means. In another embodiment, "mechanical means" refers to abrading. In another embodiment, the term 25 refers to wounding. In another embodiment, the term refers to ultrasound. In another embodiment, the term refers to radio-frequency. In another embodiment, the term refers to ab electrical process or the use of an electrical current. In another embodiment, the term refers to electoporation. In another embodiment, the term refers to exision. In another embodiment, the term refers to tape-stripping. In - 35 another embodiment, the term refers to microdermabrasion. In another embodiment, the term refers to the use of peels. In another embodiment, the term refers to any other type of mechanical means known in the art. Each possibility represents a separate embodiment of the present invention. [000145] In another embodiment, the epidermal disruption comprises chemical treatment. In another 5 embodiment, the chemical is phenol. In another embodiment, the chemical is trichloracetic acid. In another embodiment, the chemical is ascorbic acid. In another embodiment, the chemical is any other chemical capable of epidermal disruption that is known in the art. [000146] Each method or type of method of epidermal disruption represents a separate embodiment of the present invention. 10 [000147]In another embodiment, epidermal trauma is utilized in a method of the present invention. [000148] Each type of epidermal abrasion and epidermal trauma represents a separate embodiment of the present invention. [000149] In another embodiment, the epidermal disruption of methods of the present invention creates an abrasion at least about 1-1.5 centimeters (cm) in width. In another embodiment, the abrasion is at 15 least about 1 cm in width. In another embodiment, the abrasion is at least about 1.5 cm in width. In another embodiment, the abrasion is at least about 2 cm in width. Each type of abrasion represents a separate embodiment of the present invention. [000150]In another embodiment, the scalp, eyebrow, or scarred region is not contacted with a bandage or dressing following the epidermal disruption. In another embodiment, the scalp, eyebrow, 20 or scarred region is not contacted with an ointment following the epidermal disruption. In another embodiment, the scalp, eyebrow, or scarred region is allowed to heal for a period of time without being contacted by any substance, device, ointment, etc., that is ordinarily administered to an abrasion or wound to facilitate healing. In another embodiment, the scalp, eyebrow, or scarred region is allowed to heal for a period of time without being contacted by any substance, device, 25 ointment, etc., that is ordinarily administered to an abrasion or wound to prevent infection. In another embodiment, the period of time is the time it takes the epidermal disruption to heal. In - 36 another embodiment, the period of time is any time or range of times between 2 days and 3 weeks. Each possibility represents a separate embodiment of the present invention. [00015 1]In one embodiment, "following" refers to a period of time of about 2 days. In another embodiment, "following" refers to a period of time of about 3 days. In another embodiment, 5 "following" refers to a period of time of about 4 days. In another embodiment, "following" refers to a period of time of about 5 days. In another embodiment, "following" refers to a period of time of about 7 days. In another embodiment, "following" refers to a period of time of about 10 days. In another embodiment, "following" refers to a period of time of about 2 weeks. In another embodiment, "following" refers to a period of time of about 3 weeks. Each possibility represents a 10 separate embodiment of the present invention. [000152] In another embodiment, a method of the present invention further comprises the step of depilating the scalp, eyebrow, or scarred region. As provided herein, the findings of Example 6 show that the efficiency of EDIHN can be enhanced by depilation prior to abrasion or wound induction. 15 [000153]In another embodiment, the depilation is epilation. In another embodiment, the depilation comprises the step of waxing. In another embodiment, the depilation comprises the step of plucking. In another embodiment, the depilation comprises the use of an abrasive material. In another embodiment, the depilation comprises the use of a laser. In another embodiment, the depilation comprises the use of electrolysis. In another embodiment, the depilation comprises the use of a 2 0 mechanical device. In another embodiment, the depilation comprises the use of thioglycolic acid. In another embodiment, the depilation comprises the use of any other method of depilation or epilation known in the art. Each possibility represents a separate embodiment of the present invention. [000154] In another embodiment, a method of the present invention further comprises the step of administering a topical retinoid to the scalp, eyebrow, or scarred region. In one embodiment, the 2 5 topical retinoid induces resting (telogen) HF in the scalp, eyebrow, or scarred region to enter anagen. Each possibility represents a separate embodiment of the present invention. [000155] In another embodiment, the additional step (depilation or administration of a retinoid) is - 37 performed prior to the step of disrupting the epidermis. In another embodiment, the additional step is performed following the step of disrupting the epidermis, but prior to the addition of the compound or factor that promotes a differentiation of an uncommitted epidermal cell into a HF cell. In another embodiment, the additional step is performed concurrently with the addition of the differentiation 5 promoting compound or factor. In another embodiment, the additional step is performed following the addition of the differentiation-promoting compound or factor. Each possibility represents a separate embodiment of the present invention. [000156] In another embodiment, the additional step is performed between about two days and about three weeks before the step of abrading. In another embodiment, the additional step is performed 10 about two days before the step of abrading. In another embodiment, the additional step is performed about three days before the step of abrading. In another embodiment, the additional step is performed about four days before the step of abrading. In another embodiment, the additional step is performed about one week before the step of abrading. In another embodiment, the additional step is performed about ten days before the step of abrading. In another embodiment, the additional step is 15 performed about two weeks before the step of abrading. In another embodiment, the additional step is performed about three weeks before the step of abrading. Each possibility represents a separate embodiment of the present invention. [000157] In another embodiment, the methods of the present invention further comprise the step of contacting the scalp, eyebrow, or scarred region with an inductive cell capable of inducing an 20 epidermal cell to differentiate into an HF cell. In another embodiment, the HF cell is an HF stem cell. Each possibility represents a separate embodiment of the present invention. [000158] In another embodiment, the inductive cell is a dermal papilla cell. In another embodiment, the inductive cell is a follicular papilla cell. In another embodiment, the inductive cell is a dermal sheath cell. In another embodiment, the inductive cell is a cell that has been genetically modified; 2 5 for example, with a gene encoding a factor that activates one of the proteins or pathways shown in the present invention to be up-regulated in HF stem cells. In one embodiment, the factor is hedgehog. In another embodiment, the factor is a DP cell protein. In another embodiment, the factor is wingless/ int (wnt). In another embodiment, the factor is a Noggin protein. In another -38 embodiment, the factor is a bone morphogenic protein (BMP). In another embodiment, the factor is a fibroblast growth factor (FGF). In another embodiment, the factor is a transforming growth factor beta (TGF-beta) protein. In another embodiment, the factor is sonic hedgehog protein. In another embodiment, the factor is a neurotropin. In another embodiment, the factor is any other factor 5 known in the art that can contribute to induction of an epidermal cell to differentiate into an HF cell. Each possibility represents a separate embodiment of the present invention. [000159]In another embodiment, the inductive cell has been genetically modified with a gene encoding a factor that represses one of the proteins or pathways shown in the present invention to be down-regulated in HF stem cells. In another embodiment, the inductive cell has been genetically 10 modified with a gene encoding a factor that activates one of the proteins or pathways shown in the present invention to be up-regulated in HF stem cells upon their activation. [000160] In another embodiment, the inductive cell is an autologous cell. In another embodiment, the inductive cell is an allogenic cell. [000161] In another embodiment, the inductive cell is derived from a mesenchymal stem cell. In 15 another embodiment, the inductive cell is derived from a mesodermal progenitor cell. In another embodiment, the inductive cell is derived from a hematopoietic stem cell. In another embodiment, the inductive cell is derived from an embryonic stem cell. In another embodiment, the inductive cell is derived from an embryonic carcinoma cell. In another embodiment, the inductive cell is one of the cell types disclosed in United States Patent Application No. 2003/0201815. In another embodiment, 20 the inductive cell is any other type of cell known in the art with inductive properties for an epidermal cell. Each type of inductive cell represents a separate embodiment of the present invention. [000162]In another embodiment, the epidermal cell (e.g. the epidermal cell that is induced to differentiate into an HF cell) is an epidermal stem cell. In another embodiment, the epidermal cell is 2 5 a bulge cell. In another embodiment, the epidermal cell is any other type of cell known in the art that can be induced to differentiate into an HF stem cell. Each possibility represents a separate embodiment of the present invention. - 39 - [000163] In another embodiment, a method of the present invention further comprises the step of contacting the scalp, eyebrow, or scarred region with an anti-androgen compound. In one embodiment, the anti-androgen compound is finasteride. In another embodiment, the anti-androgen compound is Fluridil@. In another embodiment, the anti-androgen compound is dutasteride. In 5 another embodiment, the anti-androgen compound is spironolactone. In another embodiment, the anti-androgen compound is cyproterone acetate. In another embodiment, the anti-androgen compound is bicalutamide. In another embodiment, the anti-androgen compound is flutamide. In another embodiment, the anti-androgen compound is nilutamide. In another embodiment, the anti androgen compound is an inhibitor of an androgen receptor. In another embodiment, the anti 10 androgen compound is any other anti-androgen compound known in the art. Each possibility represents a separate embodiment of the present invention. [000164] In another embodiment, a method of the present invention further comprises the step of contacting the scalp, eyebrow, or scarred region with an estrogen compound. In another embodiment, a method of the present invention further comprises the step of contacting the scalp, 15 eyebrow, or scarred region with an estrogen receptor agonist. In another embodiment, a method of the present invention further comprises the step of contacting the scalp, eyebrow, or scarred region with an estrogen analogue. In one embodiment, the estrogen analogue is estradiol. In another embodiment, the estrogen analogue is 17 beta-estradiol. In another embodiment, the estrogen analogue is 17 alpha-estradiol. In another embodiment, the estrogen analogue is ZYC3. In another 20 embodiment, the estrogen compound, estrogen receptor agonist, or estrogen analogue is any other estrogen compound, estrogen receptor agonist, or estrogen analogue known in the art. Each possibility represents a separate embodiment of the present invention. [000165] In another embodiment, a method of the present invention further comprises the step of contacting the scalp, eyebrow, or scarred region with an inhibitor of an EGF protein. In another 25 embodiment, a method of the present invention further comprises the step of contacting the scalp, eyebrow, or scarred region with an inhibitor of an EGFR. In another embodiment, a method of the present invention further comprises the step of contacting the scalp, eyebrow, or scarred region with a compound that reduces an expression of an EGF protein or an EGFR. Each possibility represents a separate embodiment of the present invention. - 40 - [000166] In another embodiment, a method of the present invention further comprises the step of contacting the scalp, eyebrow, or scarred region with a Hedgehog protein. In another embodiment, a method of the present invention further comprises the step of contacting the scalp, eyebrow, or scarred region with a nucleotide encoding a Hedgehog protein. In another embodiment, a method of 5 the present invention further comprises the step of contacting the scalp, eyebrow, or scarred region with an activator of a Hedgehog protein. Each possibility represents a separate embodiment of the present invention. [000167] In one embodiment, a scalp is treated by a method of the present invention. In another embodiment, an eyebrow is treated. In another embodiment, any other hair-bearing area or region of 10 the skin is treated. Each possibility represents a separate embodiment of the present invention. [000168] In another embodiment, a method of the present invention further comprises the step of contacting the scalp, eyebrow, or scarred region with a lithium compound. In one embodiment, the lithium compound contains a lithium ion. In another embodiment, the lithium compound contains a lithium atom. 15 [000169] In another embodiment, a method of the present invention further comprises the step of contacting the scalp, eyebrow, or scarred region with (2'Z,3'E)-6- bromoindirubin-3'-oxime (BIO). In another embodiment, a method of the present invention further comprises the step of contacting the scalp, eyebrow, or scarred region with any other compound known in the art that is capable of inducing an epidermal cell to differentiate into an HF stem cell. Each compound represents a 2 0 separate embodiment of the present invention. [000170] In one embodiment, the compound administered as part of methods of the present invention is administered systemically. In another embodiment, the compound is administered topically. In another embodiment, the compound is administered to the site of the abrasion. In another embodiment, the compound is administered to the site of the wound induction. In another 25 embodiment, the compound is administered to the site of the depilation. In another embodiment, the compound is administered during wound healing. In another embodiment, the compound is administered prior to HF neo-genesis. In another embodiment, the compound is administered during HF neo-genesis. Each possibility represents a separate embodiment of the present invention. - 41 - [000171 ]In another embodiment, the present invention provides a method of inducing formation of an HF stem cell, comprising performing a method of the present invention. In another embodiment, the present invention provides a method of inducing formation of a DP cell, comprising performing a method of the present invention. Each possibility represents a separate embodiment of the present 5 invention. [000172] In another embodiment, homologues and variants of transcripts and proteins of the present invention are administered in methods of the present invention. In another embodiment, homologues and variants of transcripts and proteins of the present invention are targeted in methods of the present invention. Each possibility represents a separate embodiment of the present invention. 10 [000173] The terms "homology," "homologous," etc, when in reference to any protein or peptide, refer in one embodiment, to a percentage of amino acid residues in the candidate sequence that are identical with the residues of a corresponding native polypeptide, after aligning the sequences and introducing gaps, if necessary, to achieve the maximum percent homology, and not considering any conservative substitutions as part of the sequence identity. Methods and computer programs for the 15 alignment are well known in the art. [000174] In another embodiment, the term "homology," when in reference to any nucleic acid sequence similarly indicates a percentage of nucleotides in a candidate sequence that are identical with the nucleotides of a corresponding native nucleic acid sequence. [000175] In another embodiment, "homology" refers to identity of greater than 70%. In another 20 embodiment, "homology" refers to identity of greater than 75%. In another embodiment, "homology" refers to identity of greater than 80%. In another embodiment, "homology" refers to identity of greater than 82%. In another embodiment, "homology" refers to identity of greater than 85%. In another embodiment, "homology" refers to identity of greater than 87%. In another embodiment, "homology" refers to identity of greater than 90%. In another embodiment, 2 5 "homology" refers to identity of greater than 92%. In another embodiment, "homology" refers to identity of greater than 95%. In another embodiment, "homology" refers to identity of greater than 97%. In another embodiment, "homology" refers to identity of greater than 98%. In another embodiment, "homology" refers to identity of greater than 99%. In another embodiment, -42- "homology" refers to identity of 100%. [000176] Protein and/or peptide homology for any amino acid sequence listed herein is determined, in one embodiment, by methods well described in the art, including immunoblot analysis, or via computer algorithm analysis of amino acid sequences, utilizing any of a number of software 5 packages available, via established methods. Some of these packages may include the FASTA, BLAST, MPsrch or Scanps packages, and may employ the use of the Smith and Waterman algorithms, and/or global/local or BLOCKS alignments for analysis, for example. Each method of determining homology represents a separate embodiment of the present invention. [000177] In another embodiment, the present invention provides a kit, comprising a tools and/or a 10 compound suitable for performing a method of the present invention. [000178] In another embodiment, the present invention provides a device, comprising a tool suitable for epidermal disruption and a means of delivering a compound or factor that promotes a differentiation of an uncommitted epidermal cell into a HF cell. [000179] In other embodiments, the present invention provides a method of treating any disease, 15 disorder, or symptom associated with balding. In other embodiments, the present invention provides a method of treating any disease, disorder, or symptom associated with balding. In other embodiments, the present invention provides a method of treating any disease, disorder, or symptom associated with balding. Each disease, disorder, or symptom represents a separate embodiment of the present invention. 20 Pharmaceutical Compositions [000180]In another embodiment, methods of the present invention comprise administering a pharmaceutical composition comprising the HF stem cell-inducing or -activating compound and/or its analog, derivative, isomer, metabolite, pharmaceutically acceptable salt, pharmaceutical product, hydrate, N-oxide, or any combination thereof; and a pharmaceutically acceptable carrier. Each 2 5 possibility represents a separate embodiment of the present invention. - 43 - [000181] The pharmaceutical compositions containing the HF stem cell-inducing or -activating compound can, in another embodiment, be administered to a subject by any method known to a person skilled in the art, such as topically, parenterally, paracancerally, transmucosally, transdermally, intramuscularly, intravenously, intradermally, subcutaneously, intraperitonealy, 5 intraventricularly, intracranially, intravaginally or intratumorally. Each possibility represents a separate embodiment of the present invention. [000182] In another embodiment, the pharmaceutical compositions are administered orally, and are thus formulated in a form suitable for oral administration, i.e. as a solid or a liquid preparation. Suitable solid oral formulations include tablets, capsules, pills, granules, pellets and the like. 10 Suitable liquid oral formulations include solutions, suspensions, dispersions, emulsions, oils and the like. In one embodiment of the present invention, the HF stem cell-inducing or -activating compounds are formulated in a capsule. In another embodiment, the compositions of the present invention comprise, in addition to the HF stem cell-inducing or -activating compound active compound and the inert carrier or diluent, a hard gelating capsule. 15 [000183] In another embodiment, the pharmaceutical compositions are administered topically to body surfaces and are thus formulated in a form suitable for topical administration. Suitable topical formulations include gels, ointments, creams, lotions, drops and the like. For topical administration, the HF stem cell-inducing or -activating compound or its physiologically tolerated derivatives such as salts, esters, N-oxides, and the like are prepared and applied as solutions, suspensions, or 2 0 emulsions in a physiologically acceptable diluent with or without a pharmaceutical carrier. [000184] In another embodiment, the pharmaceutical compositions are administered by subcutaneous implantation of a pellet. In another embodiment, the pellet provides for controlled release of HF stem cell-inducing or -activating compound agent over a period of time. [000185] For liquid formulations, pharmaceutically acceptable carriers are, in another embodiment, 25 aqueous or non-aqueous solutions, suspensions, emulsions or oils. Examples of non-aqueous solvents are propylene glycol, polyethylene glycol, and injectable organic esters such as ethyl oleate. Aqueous carriers include, in another embodiment, water, alcoholic/aqueous solutions, emulsions or suspensions, including saline and buffered media. Examples of oils are those of petroleum, animal, - 44 vegetable, or synthetic origin, for example, peanut oil, soybean oil, mineral oil, olive oil, sunflower oil, and fish-liver oil. [000186] In one embodiment, the pharmaceutical compositions are controlled-release compositions, i.e. compositions in which the HF stem cell-inducing or -activating compound is released over a 5 period of time after administration. Controlled- or sustained-release compositions include, in another embodiment, formulation in lipophilic depots (e.g. fatty acids, waxes, oils). In another embodiment, the composition is an immediate-release composition, i.e. a composition in which all the HF stem cell-inducing or -activating compound is released immediately after administration. EXPERIMENTAL DETAILS SECTION 10 EXAMPLE 1 DEPILATION AND EPIDERMAL ABRASION CAUSES DE NOVO HAIR FOLLICLE FORMATION MATERIALS AND EXPERIMENTAL METHODS Depilation and epidermal abrasion 15 [000187] Mice were anesthetized with an injection of sodium pentobarbital before the hair on the back was clipped and depilated with Nair (Carter-Wallace, New York, NY), then epidermis was removed using a rotating felt wheel as described by Argyris T, J Invest Dermatol, 75: 360-362, 1980). After scrubbing with 70% ethanol and drying under an incandescent lamp, the basal and supra-basal layers in an area of (1.5 cm) 2 cm of the inter-follicular epidermis were removed by careful abrasion with a 20 felt wheel mounted on a Dremel Moto-tool (Racine, WI). After abrasion, the skin was shiny and smooth, and there was no blood. One day later, the abraded area was covered by a fibrin crust, which fell off after 3-7 days, exposing the newly regenerated epidermis. A group of control mice was sacrificed immediately after abrasion to confirm microscopically the complete removal of the interfollicular epidermis. 25 Immunohistochemistry [000188] Skin samples were fixed in PBS-buffered 10% formalin. Six-micron thick paraffin sections - 45 were cut and stained, where applicable, with antibodies. BrdU labeling [000189] The protocol described by Bickenbach and colleagues (Bickenbach et al, Cell Tiss Kinet 19: 325-333, 1986; Bickenbach et al, Exp Cell Res 244, 184-195, 1998) was used. Mice were injected 5 with 50 milligrams per kilogram (mg/kg) bodyweight 5-bromo-2'-deoxyuridine (BrdU) every 12 hours for a total of four injections. RESULTS [000190] An area of the backs of 50-day old mice was subjected to depilation and removal of the epidermis using a rotating felt wheel. Fifteen days later, HF placodes, hair germs and other signs of 10 follicle neogenesis were present (Figure 1; arrow indicates a hair germ). Morphology of the follicles was similar to embryonic follicle development. To further characterize proliferation in the new follicles, the skin was labeled with BrdU 60 minutes before sacrifice. As depicted in Figure 2, the proliferation pattern was similar to developing follicles in the embryo. [000191] These findings demonstrate that (a) disruption of the epidermis causes generation of new 15 HF, and that this generation of new HF can occur (b) in adult subjects and (c) during telogen (50 day-old mice are in the second telogen stage of the hair cycle). EXAMPLE 2 INDUCTION OF A LARGE EXCISIONAL WOUND, BUT NOT A SMALL PUNCH WOUND, CAUSES DE NOVO HAIR FOLLICLE FORMATION 20 MATERIALS AND EXPERIMENTAL METHODS Punch wound and excisional wound induction [000192] The backs of 21-day-old mice were depilated as described for Example 1 and sterilized with alcohol, followed by 1% iodine solution. Punch wounds, 4 mm in diameter, were induced using a dermal biopsy punch, down to, but not through, the muscle fascia. Excisional wounds were full 25 thickness and 1 cm in diameter; skin and panniculus carnosus was excised using fine surgical - 46 scissors. RESULTS [000193] To test whether wounding could induce HF formation, punch wounds or excisional wounds were induced in mice. Both types of wounds exhibited contraction and re-epithelialization following 5 wound induction; however, unlike the mice receiving punch wounds, the mice receiving excisional wounds also exhibited scar formation within 10 days of wound induction (Figure 3, left panel). No follicles were evident at this time point (Figure 3, right panel). 12 days after wound induction, hair germs, with similar morphology to fetal hair germs, were observed in the wound site, following BrdU pulse labeling (Figure 4). Several markers were used to verify that the observed structures 10 were HF. The structures exhibited staining with anti-keratin 17 (K 17), an HF marker (Figure 5), and staining with anti-alkaline phosphatase at the 12 day time point verified that the structures had dermal papilli containing fibroblasts, as expected for HF (Figure 6; HF at earlier and later stages are depicted in the left and right panels, respectively). [000194] The HF generated by wound induction were further characterized by morphological 15 comparison to embryonic HF, following BrdU staining; a clear correspondence in morphology was observed at various stages (Figure 7). In addition, several markers of embryonic HF development, namely Lefl, wingless/ int (Wnt) 10b, and sonic hedgehog (Shh), were also induced in the epidermal disruption-induced HF neogenesis (EDIHN) (Figure 8). Additional BrdU staining (Figure 9) and staining for HF markers S1 00A3 and S1 00A6 (Figure 10; left panel: tissue section parallel to 20 HF axis; right panel: cross-sectional view of follicle) provided further verification that the development of the EDIHN follicles closely paralleled embryonic HF development. [000195] These findings provide further evidence that disruption of the epidermis causes generation of new HF, and that this generation of new HF can occur (b) in adult subjects and (c) during telogen (21-day-old mice are in the first telogen stage of the hair cycle). 25 EXAMPLE 3 EDIHN-INDUCED HAIR FOLLICLES GENERATE HAIRS - 47 - [000196] At 25 and 45 days after wound induction, wound sites contained new hairs (Figure 11, left and right panels, respectively). New hairs appeared to lack pigmentation, except when the wnt pathway was inhibited, using Dkk-1 (Dickkopf-1) during the first nine days after wounding (see Example 10). 5 [000197] These findings indicate that EDIHN-induced HF function normally; i.e. are capable of generating hairs. EXAMPLE 4 EDIHN HAIR FOLLICLES RETAIN THE ABILITY TO ENTER INTO CYCLICAL HAIR GROWTH 10 MATERIALS AND EXPERIMENTAL METHODS BrdU labeling [000198] 50 mg/kg bodyweight BrdU (Sigma) was injected twice per day for 3 days beginning 20 days after wounding. BrdU was detected 40 days after wounding (17 day chase). Whole mounting and immunofluorescence 15 [000199] HF whole mounts were obtained by incubating fresh skin with EDTA (20mM in PBS) at 37 'C overnight, then separating the epidermis and dermis. Epidermis was then fixed in 10% formalin for 10 min, room temperature (RT). Dermis was fixed in acetone overnight, RT. After rinsing with PBS, whole mounts were stained with antibodies for immunohistochemistry (schematically depicted in Figure 12) and were imaged using a Leica confocal microscope. 20 RESULTS [000200] To determine whether EDIHN-induced HF contain normal levels of HF stem cells, mouse skin was examined for the presence of label-retaining cells at 21 days after wound induction. Retention of BrdU during a long chase period is, under these conditions, one of the hallmarks of HF stem cells. Normal numbers and placement of label-retaining cells (in the bulge of the HF) were 2 5 observed (Figure 13). To verify that the label-retaining cells were HF stem cells, K15-eGFP mice - 48 were utilized. In these mice, eGFP (enhanced green fluorescent protein) is expressed from the K1 5 promoter; thus, expression of eGFP identifies HF stem cells. As depicted in Figure 14A, eGFP expressing cells were observed in in tissue sections (right side) of newly formed hair follicles 35 days following wound induction. eGFP-expressing cells were also seen in the epidermis whole 5 mounts (bottom, far left panel) indicating the conversion of epidermal cells into cells with hair follicle stem cell characteristics. ([bottom, second from left] panel is same as [bottom, far left] panel but viewed under white light) This finding shows that the observed label-retaining cells exhibited HF stem cell properties. [000201] To determine whether EDIHN-induced HF cycle normally, mounts were prepared from 10 additional mice at 35, 38 and 45 days after wounding. As depicted in Figure 14B, the EDIHN induced HF entered the resting phase, telogen, and then re-entered a new anagen stage. [000202] In summary, the findings of this Example show that EDIHN-induced HF contain HF stem cells, as do embryonically generated HF. The presence of the HF stem cells shows that EDIHN induced HF retain the ability to enter into cyclical hair growth in the same manner as embryonically 15 generated HF. The findings also show that wounding induces epidermal cells to assume a hair follicle stem cell state (expressing K1 5-eGFP). This model is shown schematically in Figure 15. The findings of Examples 2, 3, and 4 show that EDIHN-induced HF are fully functional and thus able to restore hair growth to a subject in need. EXAMPLE 5 20 EDIHN-INDUCES NEW HAIR FOLLICLES IN MICE AT THE TELOGEN STAGE OF THE HAIR CYCLE [000203] To determine whether EDIHN was induced new hair follicles in mice wounded at the telogen stage of the hair cycle, 21-day-old mice were subjected to EDIHN using a 1-cm excisional wound, as described in Example 2. Skin was then examined by whole-mount assay for indications of 25 new HF. As depicted in Figure 16, after 11 days, new HF were not evident by macroscopic examination (top panel), AP staining of the dermis (bottom left panel), or K17 staining of the epidermis (bottom right panel). After 14 days, as depicted in Figure 17, dermal papilla cells were - 49 detected in the dermis (left panel) and HF stem cells in the epidermis (right panel), demonstrating that new follicles were being formed. After 17 days, the new follicles were more developed, as shown by examination of the dermis and epidermis (Figure 18, left and right panels, respectively). This method induced formation of an average of 49 new follicles in the wound, a number that was 5 consistent over three separate experiments, as depicted in Table 1. [000204] Table 1. Results of three separate experiments performed on 21-day-old mice. Sample Expt 1 Expt 2 Expt 3 1 24 70 55 2 29 52 25 3 27 85 53 4 102 25 80 5 53 27 23 Avg of expts Std dev of expts Average 47 51.8 47.2 48.67 2.71 Std dev 32.8 26.3 23.7 [000205] The findings of this Example demonstrate that EDIHN is capable of inducing formation of new HF in mice at the telogen stage of the hair cycle, despite that fact that these mice do not contain HF at the anagen stage during wounding. 10 EXAMPLE 6 IN ADULT MICE, INDUCTION OF ANAGEN INCREASES THE EFFICIENCY OF EDIHN [000206] The experiment described in Example 5 was repeated with mice of different ages, and therefore at different stages of the hair cycle. To ensure that wound scarring occurred, larger wounds 15 were in induced in the older mice. As depicted in Table 2, adult mice at telogen, such as 8-week-old mice, exhibited lower efficiencies of HF formation by EDIHN. [000207] Table 2. Efficiency of HF formation by EDIHN in adult mice at various stages of the hair cycle. - 50 - Age Wound size Days after wound Mice exhibiting EDIHN Hair cycle 3 wk 1 cm 20 25/25 (100%) Telogen 4 wk 1 cm 20 5/5 (100%) Early anagen 5 wk 1 cm 20 1/2 (50%) Anagen 8 wk 1.5 cm 30 16/35 (46%) Telogen 14 wk 1.5 cm 30 1/2(50%) N/A* 20 wk 1.5 cm 30 2/2(100%) N/A* * The second telogen lasts approximately 40 days in mice. Thus, 14-week-old and 20- week-old mice contained a mixture of telogen and anagen HF. [000208] To determine whether experimental induction of anagen increased the efficiency of EDIHN, 8-week-old mice were depilated several days prior to wound induction. As depicted in Figure 19, the 5 wounds closed similarly whether or not they were preceded by depilation. As depicted in Figure 20A-B, the depilated mice exhibited enhanced EDIHN relative to the non-depilated mice depicted in the previous Example by a factor of 11-fold. [000209] The findings of this Example demonstrate that anagen induction enhances EDIHN. In addition, these findings show that EDIHN is capable of not only forming new HF, but also of 10 activating anagen in pre-existing HF in the telogen stage. EXAMPLE 7 EDIHN-INDUCES NEW HAIR FOLLICLES IN HUMAN SKIN MATERIALS AND EXPERIMENTAL METHODS Grafting 15 [000210] Discarded human adult scalp from the preauricular area obtained from plastic surgery was grafted onto immunodeficient (scid) mice. The graft was bandaged and allowed to heal, then was used in the wound healing study 3 months after grafting. RESULTS -51 - [000211] To determine whether human skin responded to EDIHN as did mouse skin, human skin was grafted onto SCID (immuno-deficient) mice and subjected to depilation by plucking and wound induction three days later. Seven days following wound induction, formation of new HF was observed in the human skin (Figure 21A; arrows indicate new HF) by hematoxylin and eosin 5 staining of paraffin embedded tissue sections. [000212] In additional experiments, adult human skin was grafted onto mice, abraded, and examined at 7 days post-abrasion. New HF were generated in the human skin, which mimicked normal hair follicle formation during fetal development, as evidenced by staining for S1 00A6 or S1 00A4 (Figure 21B). 10 [000213] The results of this Example show that EDIHN can be used to generate hair growth in human skin as for mouse skin. EXAMPLE 8 MOLECULAR PATHWAYS ACTIVATED DURING HF STEM CELL ACTIVATION MATERIALS AND EXPERIMENTAL METHODS 15 Isolation and activation of HF stem cells [000214] K15-eGFP mice were depliated in order to induce formation of new HF. Activated hair follicle stem cells were isolated from K15-eGFP mice using fluorescence-activated cell sorting (FACS) two days after depilation and 5 tg (micrograms) total RNA from the cell population was isolated, reverse-transcribed and hybridized to an Affymetrix (Santa Clara, California) array 20 MG_U74v2 chip. Scanned chip images were analyzed using Affymetrix Microarray Suite 5.0 and GeneSpring software (Silicon Genetics) to detect fold-change differences between activated HF stem cells (HFSCs) and non-activated (telogen) HFSCs. Values were normalized before computing fold-changes and differences between non-activated "bs-line" and activated ("expt") samples. RESULTS 2 5 [000215] To identify molecular pathways up-regulated during HF stem cell activation, activated HF - 52 stem cells were isolated, and the gene expression patterns of the cells were analyzed to detect up regulated transcripts. The transcripts depicted in Table 3 were up-regulated at least 2-fold in the activated HF stem cells relative to the cells prior to activation. In some cases, the sequence in Table 3 is a genomic sequence that contains the sequence of the transcript. Data pertaining to the up 5 regulation of the transcripts and further information about them is provided in Figure 22. [000216] Table 3. RNA transcripts up-regulated during HF stem cell activation. SEQ Access. # Sequence ID No: uuuuuuuuuuuuuuuuucuuaaaaauauaaauguauuugucugcaucaugacguucuucgg accuagcuggccagaccacuggccaugggacaaggaggaagucagguguaagucugagcaagg, acaggacucugcccuggcaggguggagguggccucacagugucccaugcugggccugguagcg gaaagcacagcacgguagugggacagcuccugccgcacagccaccaccuccugccgcaacaggg( AW04734 guuuuccuucuccaggaaggcagcccgcacagauauccgguucuccuugagucuucuugcauc 1 3 c 2 AF053235 Sequence below. caguuccucagcauggccaccugcagccgccaguucaccuccuccagcuccaugaagggcuccuguggcaucggugguggcu cuagccgcauguccuccauccuggcuggaggauccugccgggcucccagcaccugcgggggcaugucaguuaccuccucucg cuucuccucugggggagucugugggauuggagguggcuauggugggagcuucagcagcagcaguuuugguggaggacuugg 10 uaguggauuugguggucgauuugauggauuugguggugguuuuggugcuggucuuggugguggucuuggcggugguauu ggugaugggcuccuggugggcagugagaaagugaccaugcagaaccucaaugaccgccuggccaccuaccuggacaaggugc gugcccuggaagaggccaacagagaccuggaggugaagauccgggacugguaccagaggcagcggcccacugagaucaaagac uacagccccuacuucaagaccauugaggaccugaagagcaagaucauuauugccacccaggagaaugcacaguucacuuugca gauugacaaugccaggcuggcagcugaugacuucaggaccaaguacgagaaugagcuguucuugcggcaguccguggagggu 15 gacaucaauggccugcgcaaggugcuagaugagcugacccuguccagagcugaccuggaaaugcagauugaaaaccucagaga agagcuggccuuccugaagaagaaccaugaggaggagaugcuugccuugaggggucagacugguggggacgucaauguggag auggacgcagcccccgguguggaccucagccgcauucugaaugagaugagggaccaguaugagcagauggcagagaagaaccg cagagauguggaggccugguuccugagaaagacugaggagcugaacaaagagguggccucuaacagugaucuaauccagagc aaccgcagcgagguggcugagcuccgcaggguguuccagggccuggagauugaacugcagucccagcucagcaugaaagcau 20 ccuuggagaacagccuagaagagaccaaaggcagauacuguaugcagcugucccagauccaggguuugaucagcagugugga ggagcagcuggcucagcuucgcugcgagauggagcagcagagccaggaguacaacaucuuguuggaugugaagacaaggcug gagcaggagaucgccaccuaccgccgucugcuggauggcgagaauauccacuccuccucacagcacuccucuggacaguccua uucuucucgagaagucuucuccucauccucccgccagccccgguccauccucaaggagcaagguucaaccagcuucagccaga gccaaagucagaguuccagggacuaauguuuugccuagagccuccucacccacaacugccucucaagcugagggcuuggggc 25 aggacccuguuuucuuugcgcauuccccaucugucuccccuacccucucauggugguaggcuaauaaagcuuuuugguuga ugcaaaaaaaaaaaaaaaaaa - 53 gcgccaguccuccgauagacugagucgcccggguacccguguucucaauaaagccucuug cuguuugcauccgaaucguggucucgcugguccuugagagggucuccucagauugauugac uacccacgucgggggucuuucauuuggaggccccagcgagauuuggagaccccugcccaggg accaccgaccccccgucgggagguaagcuggccagcggucguuucgugucugucucugucuu cgugcguguuugugccggcauuuaauguuugcgccugcgucuguacuaguuagcuaacuag aucuguaucuggcgguuccgcggaagaacugacgaguucguauucccggccgcagccccugg gagacgucccagcggccucgggggcccguuuuguggcccauucuguaucaguaaccacccga gucggacuuuuuggagcuccgccacuguacguggcuuuguugggggacgagagacagagaca cuucccgcccccgucugaauuuuugcuuucgguuuuacgccgaaaccgcgccgcgcgucuga uuuguuuguuguucuuuuguucuucguuaguuuucuucugucuuuaaguguuuuucgaga ucaugggacagaccguaacuaccccucugaguuuaaccuugcagcacuggggagauguccag cgcauugcauccaaccagucuguggaugucaagaagaggcgcuggauuaccuucuguuccgc ugaauggccaacuuucaaugugggauggccucaggaugguacuuucaauuuaaguauuaucu cucagguuaagucuagaguguuuuguccugguccccacggacacccggaucaggucccauau aucgucaccugggaggcacuugccuaugaccccccuccgugggucaaaccguuugugucucc uaaacuuccucccucgccgacagcucccguccucccgcccgguccuucugcgcaaccuccguc ccgaucugcccuuuacccugcccuuacccccucuauaaaguccaaaccuccuaagccccaggu ucucccugauagcggcggaccccucauugaccuucucacagaggaccucccgccguacggagc acaaccuuccuccucugccagagagaacgauaaagaagaggcggccaccaccuccgagguuuc ccccccuucucccauggugucucgacugcggggaaggagagacccucccgcagcggacuccau caucucccaggcauucccacuccgcauggggggagauggccagcuucaguacuggccguuuu 3 M26005 ccuccucugauuuaacccuuccuuuucugaagauccagguaaauugacggccuuga gacguagagccccuugcgcccgguuuccugaucccgcuuacuccucugcgcgccggcaggau ggcccacaagcagaucuacuacucagacaaguacuucgaugagcacuacgaguaccggcaugu cauguuacccagagaacucucuaaacaaguacccaaaacucaucugauguccgaagaggagug gaggagacuugguguccaacagagucuaggauggguucauuacaugauucaugagccagaac cgcauauucuucucuuuagacgaccucuuccaaaagaacaacaaaaaugaagugcagcuggga ucaucuaaucuuuuucaaauuuaauguauauguguauauaagguaguauucagugaauacu ugaaaaguguacaaaccuuucauccauaccugugcaugcgcuguauucuucacagcaacaga 4 AA68 1998 gcucagucaaaugcaacugcaaguagg - 54 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cugugaucacguggcuguucuuguaguunaaccagggcaacacuauauauuccaggucua 20 0 uacauugcugaggucuuuuucugguuguucauguaucaguguuuucaaccucgugccg -62- 21 1U57524 ISequence below. gcggccgcggcuccagaccccggccuugcgcacccuccccccaccuccagcccgcgccucccccccccccacgcauggcucacc accccucggguuucccugucaucccucagguuccugcacuuggcaaucauccacgaagagaagccgcugaccauggaaguca uuggucaggugaagggagaccuggccuuccucaacuuccagaacaaccugcagcaggugcgcugcuugcuugccccgcggu gccccucuuugaccccuugguggagucagauguagcacggucgcccccaaagcguuucuaaauuaauagucacuuaguucu 5 uaucugccuuggcuuuuuugcauucaaaucagccaacgucuuagaaccagaagaaaaaucccuugguuuuagugaggucuu uaugacccaccuagggccuccuguuugccugaucuccuaagagacaaaugggaggaucagauuccauagcgggaggugucu gggguucaggaaacucaagacuauggguuugcuccauggcuuaucccuuucuguuuccucuuccauuuguagacuccacuc cacuuggcugugaucaccaaccagccaggaauugcugaggcacuucugaaagcuggcugugauccugagcuccgagacuuuc gaggaaauaccccucuacaucuugccugugagcagggcugccuggccaguguagcagucuugacgcagaccugcacacccca 10 gcaucuccacuccguccugcaggccaccaacuacaaugguaggucugccaguccauccaaggaugcagaggagggagagaga 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gccucuuccuccuucuucuaggcugcugcuccugcugucccgugggcugcuccaaaugug cccagggcugugucugcaaaggcgccgcggacaagugcacgugcugugccugaugugacg aacagcgcugccaccacguguaaauaguaucggaccaacccagcgucuuccuauacaguu ccacccuguuuacuaaacccccguuuucuaccgaguacguuaauaauaaaagccuguuug agucuaacucugguuucuuggugugguuuggcaauaagaaacuggggugacuugauaguc uggggaucugguuuuggacccccucgugccuuuaccuccgcccucuggcccucacagagg 24 V00835 gguaaugucuuuggguaaagccaagcuauaucccauaagcuuccucauggaaaacagcug gcggcacgaugugucuucggguggcuuuuuuuuuuuuguuuugaauaauguuuacaauuu cccucaaucacuuuuauagaaauccaccuccaggccccccccuuuccccacuuaggccuu cgaggcugucugaagaugcuugagaaacucaaccaaaucccaguucaauucagacuuugc acauauauuuauauuuauaaucagaaaagaaacauuucaguaauuuauaauaaaagagca 25 AV374868 cuauuuuuuaacg 26 M21285 See above (same Accession Number). - 65 acugccaucgagugguguuccaguugaacuugcucucucugccaucugcuccgcgggcgc cgucagcaugggucccuggacccacuccuugcgcgccguccugcugcuggugcuuuuggg agucugcaccgugcgcuccgacacuccugccaacugcaccuacccugaucugcugggcac cuggguguuccaggugggcccuagaaguucccgaagcgacauuaacugcucggugaugga 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cuuccuacacuaccacaguggaaucuaucaccacacugggcugagugacccuuucaaccc cuucgagcugacaaaucaugcuguuuugcuugugggcuauggaagagauccaguuacugg gauagaauacuggauuauaaagaacagcuggggcucuaacuggggggagaguggcuacuu ccguauccgcagaggaacugaugaaugugcaauugagaguauagccguggcggccauacc gauuccuaaauuauaggacauagcucccaguguuacauacgggucuuuaucacucacaga gugauuuagucacaugcugaagacuuuuucagagcaauaucagaagcuuaccacuaagca ucuuuaaagaauuuugucuuugaacuuaaaaccauccuugauuuuuuucuuuuaauaucu uccccaucaacuacugaacuacuuuucuuuuuaaaguacuugguuaaguaauacuuuuau gagcagugguucaguuguccaauauuuuuugcaggucaucuacaaugcaaccagauguuu caguucuaaaaaucuauguaaaaguacaagcucguuuuuaaauuauguaagucacaugaa aacauggcaaaaaaauuaguuaaauuuuuuacaaagaguuuuaaauaaauguuuauguaa ucaguaccauagucuuucuauguguguuuacaagaauuuuugucaccuacuucuucccuu 27 U74683 agaagcauuuaugcuccauggacguacuucuuuauggagaaaaaaaaaa -66gagcucgaucccuguuccgccuuugcuaugucugaaggcguccugcuuugcgcgugucgg ggccaaauccagauuuucauuucgcuccaggcuuggacggcuaaguagguccaaaccgca caaacaggaaggagggaaggcaaggagugcgggcagagggcgggucguucccagcagcac 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gagacucugaacgaccuauaccucagaccccgacagcggggagcagacgccgcccgaauc gcuaguuucuuugggaccugcgagcgacaggaagcugcagcuugggcacuggacugcgag agaagcuauauuaaucuuuccccuuaaauuauuuuuuauaaugguagcauuuucuacguc uuauuaccauugcagcuaagguacauuuguagaaaagacauuuccgacagacuuuuguag auaagaggaagagacugcgcaugcuuuuuauauucauuuuuacaguauuuguaagaauaa 28 X61800 gaauaagaauaaagaagcauuuaaaucgcaaaaaaaaa 29 U20735 Sequence below. uugaggguggccaggccagcguaggaggccagcguaggauccugcugggagcggggaacugagggaagcgacgccgagaaag caggcguaccacggagggagagaaaagcuccggaagcccagcagcgccuuuacgcacagcugccaacuggccgcugccgaccg ucuccagcucccgaggacgcgcgaccggacaccggguccugccacagccgaggacagcucgccgcucgccgcagcgagcccgg ggcggcccuucagggggaccuuucccagaucgcccaggccgcccggaugugcacgaaaauggaacagccuuucuaucacgacg 5 acucuuacgcagcggcgggauacggucggagcccuggcagccugucucuacacgacuacaaacuccugaaacccaccuuggcg cucaaccuggcggaucccuaucggggucucaaggguccuggggcgcgggguccaggcccggagggcaguggggcaggcagcu acuuuucgggucagggaucagacacaggcgcaucucugaagcuagccuccacggaacuggagcgcuugaucguccccaacagc 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cgagguuuacauggcccccuuccagcguauuuuguauguuuuuuuuuucugcaaagagacugaauucauauugaauauaau - 67 auauuuguguauuuaacaggagggagaagggggcugucgcggcggagcuggccgccgcuugguacucagcugcggggauac uagggagggaccuccgcccccugcccucccccucugcauaguacuguggagaagaaacacgacuucgugucuaaagucuauu uuaagauguguuuguguguguguguuugacuuuuuauugaaucuauuuaagua 30 U19118 Sequence below gaauucggcacgagcagcgagacgccgcgcacggugcuuccccaguggagccaaucggcuaacccgcgcuccggcagaguc 5 uuggcgcucgcccgccggcgggacagaccacccgccucuggccgcucucuggacccuggccgccccgagcgaagacuggagc aaaaugaugcuucaacauccaggccaggucucugccucagaagucagugcgaccgccauuguccccugccucucaccuccug ggucacugguauuugaggauuuugcuaaccugacacccuuugucaaggaagagcugagauucgccauccagaauaaacaccu cugccaucggauguccucugcgcuggagucaguuaccgucaacaacagaccccuggagaugucagucaccaagucugaggcg gccccugaagaagaugagaggaaaaggaggcggcgagaaagaaauaaaauugcugcugccaagugucgaaacaagaaaaagga 10 gaagacagagugccugcagaaagagucagagaaacuggagagugugaaugcugagcugaaggcccagauugaggagcugaag aaugagaaacagcauuugauauacaugcucaaccugcaccggcccaccuguaucguccgggcucagaauggacggacaccgg 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gugcaccccaaugugaucugugaugguugcaacgggccuguggugggaacucgcuauaagugcagugugugcccagacu acgaccugugcagcgugugcgaggggaagggccugcacagggaacacagcaagcucaucuuucccaaccccuuuggccac cucucugauagcuucucucauagccgcuggcuucggaagcugaaacauggacacuuuggcuggccuggcugggagaugg gcccaccggggaacuggagcccacguccuccucgugcaggggauggccgcccuugcccuacagcugagucagcuucugcu ccaccagaagaucccaaugucaauuuccugaagaaugugggggagaguguggcagcugcccucagcccucuaggcauuga gguugacauugauguggaacauggagggaagagaagccgccugacacccacuaccccagaaaguuccagcacaggcacag aagacaagaguaacacucagccaagcagcugcucuucggaagucagcaaaccugacggggcuggggagggcccugcucag ucucugacagagcaaaugaaaaagauagccuuggagucggugggacagccagaggaacagauggagucgggaaacugcuc aggaggagacgaugacuggacacauuugucuucaaaagaaguggacccaucuacaggugaacuccagucucuacagaugc cagaaucggaagggccaagcucucuagaccccucacaggaaggacccacagggcugaaggaagcugcccuauacccacauc ucccaccagaggcugauccccggcugauugagucccucucccagaugcuguccauggguuucucggaugaaggcggcug gcucaccaggcuccuacagaccaagaauuacgacaucggggcugcucuggacacgauccaguauucgaagcacccuccacc auugugauagugcuguggccaagccccacccccuuugucuuguaguugcaucacguagagcagcagggcuucuauagau aggcccagugucuuggcauucuuguagaaucuucaggugggaaugugugaugccuuuucaggcaauaggaaagugcau gaggagaguuuugaaugugcauaugcugacgccugagaacagacccagguacccguggcugagcugagcuuccucugcu uccccuaggccuggccucugcagggaacugcagcacacacugcacucccaccugcucuugccgccagcauugcaccagca guccagaauuccugccugacaacccguguuuccuuuauuaaaagugauuaguacaacugcuaguuauuuucaacaaaua aagccauuauguuaagaggggacuguccauagugagugaaagguggcaggcaggggccuacagcuccuagggaauggag aauucaugugaagccgaaugaaggaucuuaucuuauacugucccccuuucuaauggccacucuuuaguguuugugucua auguuaaugcuuaaagcacaggacccccauguagcuuccucugacuugguuuguaaguaaccuguaauaaaaugccaua ugcacuuuaacca 92 D26090 Sequence below. - 103 gagggaauugcgggaccccgucuggggaagcucccgccgccccggggugcucagcucucugucucccuugacccaggua cagucaugucgggcuucgacgacccgggcauuuucuacagcgacagcuucgguggcgaccccggugcggaagagggcca ggcccgcaagucgcaacugcagaggcgauucaaggaguuccugagacaguaccgagugggcaccgaucgcacgggcuuca ccuucaaguacagagaugaacucaagcggcauuacaaccugggugaauacuggaucgagguggagauggaggaccuggcc aguuuugacgaggaacuggcugaccacuugcauaaacagccggccgagcacuuacagcugcuugaggaagcugccaagga gguggcagaugaggugacccggccccggccagcuggagaugagcugcuccaagacauccaggucaugcucaagucagaug ccagcccgucgagcauucggauucugaagucagacaugaugucacaccuggugaagaucccuggcaucaucauuucagcc ucugcaguccgugccaaggcuacucguaucuccauucagugccgcagcugccacaacacccucaccaauaucgccaugccc aggccuagagggcuaugccuucccaggaagugcaauauggaucaggcugggcgcccaaagugcccacuggauccauacuu caucaugccugacaagugcaaguguguggacuuccagacucugaaacugcaggagcugccugaugcagucccucauggug agaugcccaggcacaugcagcuuuauugugacagguaccugugugacaagguuguuccugggaacagggucaccaucaug ggcauuuauuccaucaagaaguuuggcuugaaccccagcaagggccgggacaggguaggugugggcauccggagcucgua cauccgagugcugggcauccagguggacacagauggcucuggccgaagcuuugcugggucugucagcccacaggaagagg aggaauuucgucgccuggcugcccuccccaacauauaugagcucaucuccaagagcauuucccccuccaucuuugggggc auggauaugaagaaggccauugccugccugcuuuuuggggguucccggaagaggcucccagauggacucacucgccgagg ugauaucaacuugcugauguugggagacccugguacagccaagucucagcuucugaaguuuguggagaagugcucuccc auugggguguacacaucugggaaagguagcagugcugcaggcuugacugccucagugauacgggaccccucaucucgaaa cuucaucauggaagguggagccaugguucuggccgauggugggguugucuguauugaugaguuugacaagaugcgggaa gaugaccguguugcaauccaugaggcuauggagcagcagaccaucuccauugcuaaagcugggaucacuaccaccuugaa cucucgcugcucuguucuggcugcagccaacucaguguuuggccgaugggaugagacaaaaggggaggacaauauugac uucaugccuaccaucuugucccgauuugauaugaucuucaucgucaaagaugagcacaaugaggagagggacaugaugcu agccaaacaugugaugacucugcaugugagugcacugacacagacacaggcuguggagggugagaucgaccuggccaaga ugaagaaguucauugccuacugccgagcgagguguggaccucggcuaucagcagaggcagcagagaagcugaagaaccgc uacaucaucaugcggaguggggcucgucagcaugagagggacagugaccggcguuccagcauccccaucacugugcggca gcuggaggcuauugugcgcauugcugaggcccucaguaagaugaaacugcagcccuuugccacugaggcugauguagag gaggcauugagacuguuccagguguccacacuggaugcugcuuugucuggcaaucugucggggguggagggcuucacua cccaggaggaccaggagaugcugagccgcauugagaagcaacucaagcgccguuuugccauuggcucucaggugucugaa cacagcauuguccaggacuucaccaaacagaaauauccagagcacgcuauccgaaaggugcugcagcucaugcuacgcagg ggugagauccaacaccguaugcagcgcaaggugcucuaucgccucaagugagcccauugcccaucaacccucaagccugaa augcugccaccacccuaucucccagucagugcuccaaaccuccuuuugcccugccucuccaccucagacugcugucugca gcacaucugcagccccuggaaauguacuuuggucuguuggcucauacuguguuugagugucugaggacucucugcucug ggugucuauccccugucaugccuucucaacaagaugagucuggagcaggaacaggcccuggaauguagaugggucugua uauuggcucccgggccacucacugccaagcuucuuuguauguacagagguaauaaagcaauugagucccuggcugcuaag gucaguggacccagu ggaugcagccggaagugcagcgugcgugcgguuuggugggucgcugugugcgcuccgcgu gugcagccgcgugggccauggggcggcgggcgcggggccggcgguuccagcagccgccgc agccugagggcgaggaagacgccagcgacggcggcagaaagcgaggccaggcgggcuggg aagguggcuaucccgagaucguaaaggagaacaagcucuucgagcacuacuaucaggaac ucaagaucgugccagagggagaaugggaccaauucauggagucacuccgagaaccucucc cagccacacugagaaucacuggguacaaaagccaugccaaagagauucuccauugcuuga agaacaaguacuuuaaggaguuggagganccugaaguagauggacagaaaguugaguucc 93 A17 87627 acaaccacuaagcugguacccugaagaacu - 104gagcucaaauucuggcuuucuauuggguacgauauauuaaccaaugggagaaacacaaac agaauaccuccaguuaguauaaaugcuugcuguucaguugcagaauuuacuauauauucu uuuccuuucucugcuuugccuuuacugauacuuaaacgcauacaugucuggacgcggaaa gcaagggugcaaggcccgcgcuaaggccaagacccgcuccucccgggccggccugcaguu ccccgugggccgcgugcaccggcugcuccgcaagggcaacuacucggagcgcgugggcgc cggcgccccgguguaccuggcggcugugcuggaguaccugacggccgagauccuggagcu ggcgggcaaugcggcccgcgacaacaagaagacgcgcaucaucccgcgccaccugcagcu ggccauccgcaacgacgaggagcucaacaagcugcugggccgcgugaccaucgcgcaggg cggcguccugcccaacauccaggccgugcugcugcccaagaagaccgagagccaccacaa ggccaaggggaaguaaucuggcgauugucuguacugcccaguugaaaguuaaccaaaaca aaggcucuuuucagagccacccacaucuuuccauaaaaugagcugccaccucgugaaacg uucuuccacuacaguuuuuauacuacauaugaaaaaguuacgaaguagcuuucaaucuua guaaauugauuuuaauacuguuagucccugcgauaaaucuuacgaccuuccuuaguuuga gucaaaaguguguaagagaugaaaccuuuagaacauacuauaaauuuuuaguagaaauuu ggcacccagguuugucauucacgucacgauugucuagagcauaaugguaguaagggcuaa 94 M33988 gggccauuaaaucccacuuccauaguuuc uuuuuuuuuuuuuuuuuggaaaugaagguaauuuauugaaacugguuuugggacaggcga guggacaacuguugaaaggagcuagcgcacagccgggugggagcgggugcuuagccacag auccuaucugaggcccaacuuuuucuuuuccuucugcuucuuacggaccacauccagguu ccgguccuuccacaugcuuuugcgaagcuugauggggcgugagcccacauacuucccauu caucucucgcauggcgcgcacauagucacuggggucuuugaagcugacaaagccauagcc 95 A1845182 cuugguuuugccugugcgcuuguca uucggauccuugccaauauauguaucccauuuggaauggugaucuuaaaaugugagugca ugcauacuaucuuauuuaagauacuugcaccccacccacucccaucucccgaagcuggaa cacugccaacuagguccuuaagaaucacgcaauuaacacaagguugggugcugcuaauuc uucaugaaaauccaaacacguuaagggaccagggagaugccacugccccccugaauuuuc aucaaaaauagacacguuuauguaaacagaacuauuuuccauauucauagugacuuuuua aguauuugagccuaaagauuuugaucuccauuuuuauaacuauuuaaauuguucacaauu 96 AA619207 auuacau cggccgccgccgcccccacacugccccgcguugacgagcgccgcgacggcaaggacagcg ccucgcuuuucgugguggcucggauccuagcggaccucaaccagcaggcgccggcgcccg cccccgcggaacgcagagaaggggccgcugcgcgcaaggcgaggacccccugccgccugc cgccugcgcccccugcgccgccacccggcccagagcccgccuccccgggacaagcaggcg cgccggccgcgccccccagccccgcguggagcgagccggaggcggcauuggagcaggagc AW12578 ccggccccgcggggagcggcgagccuggccucagacaaaggggucggggaggccggagcc 97 3 gcgcggaccucgaguccccgcagaggaagcacaagugccacuacgcgggcugcgagaa 98 J04103 Sequence below. cgucaguccccgccaccuccccggccccgcgcgcccggaucggcccuacggccucgucucgcccggccuugcgcgccgggacc gccgcgaucuccucuccccgccgcccuccggcuggcccugccugcugcggcgcgaugaaugacuuuggaaucaagaacaugg accaaguggccccugucgccaacaguuuucgugggacacucaagcgccagccagccuuugacaccuucgauggcucucuguu ugcugugcucccuucucucagugaagaucagacacuccaagaagugcccacgggccuggauucugucucccaugacuggcc 5 agcugcgagcugccuuugcucacucccugcagcaaggcagugaugagccaagccuuaaaagccaccuucaguggcuuccaaa aggagcaacgacgucuuggcauccccaaaaaccccuggcuguggagcgagcagcaggugugccaguggcuucucugggccac caacgaguucagccuggugaaugugaaccugcaccaguuuggcaugaacggccagaugcuguguaaccucggcaaggagcgc - 105 uuccuggagcuggcgccugacuuugugggugacauccucugggaacaucuagagcagaugaucaaagagaaccaagaaaaga cagaagaccaauaugaggaaaacucucaccucaacgcgguuccucauuggaucaacagcaauacauuaggcuucagcauggaa caggcuccauauggaaugcaggcaccaaacuaccccaaagacaaucuccuggacagcaugugcccgccaucggccacgccugc agcucugggcucugagcuccagauguugcccaagucucggcucaacaccgucaaugucaauuacuguuccaucagccaggac 5 uuccccagcagcaacgugaauuugcucaacaacaauucuggaaaacccaaggaccacgacucuccagagaacgguggggacag cuucgagagcuccgacucgcugcugagguccuggaacagccagucgucccuacuggauguacagcggguaccuuccuucgag agcuuugaggaggacuguagccagucucugugccucaguaagcugaccauguccuucaaggacuacauccaagagaggagcg acccagucgagcaaggcaaaccaguuauuccugcagcaguacuggcuggcuucacuggaagcggaccaauccaguuguggca guuucuucuggagcuacucucugacaaguccugucaaucuuucaucagcuggacgggggauggaugggaguucaagcuugc 10 ugaccccgaugagguugcccgccggugggggaagaggaaaaauaaaccaaagaugaacuacgagaagcugagccggggcuua cguuacuacuacgacaagaacaucauccacaagacuucgggcaagcgcuacguguaccguuucguaugugaccugcagaacu ugcugggcuucacuccggaggaacugcaugccauccugggcguccagccugauacagaagacugagggccuca 99 D90146 Sequence below. auggcucuaacaacgcugcucuuggugguggcggccgcccugacccugaucgagacccgcgcgggugagugcggggucggg agggaaacagccccugugccgcguccccgcuucgcccaccggaccuccgccccuucuccacccgagccccgagcccugcucca 15 cucccggcccgcguacccgaccggggucccgggaggaggucggggucucaccgcgcgcgcccccaggcccacacucgcugc gguauuuccacaccgcugugucccggcccggacucggggagccccgguucaucaucgucggcuacguggacgacacgcaguu cgugcgcuucgacagagacgcggaaaauccgaggauggagccgcgggcgcgguggauggagcaggaggggccggaguauug ggagcgggagacacagaucgccaagggccaugagcagaguuuccaagggagccugaggacugcacagagcuacuacaaccag agcaagggcggugagugaccccgggucggaggucacuaccucuccacgucccgaaacagaggccggugaggucccgggugca 20 aaguccgagguucaggagcagaacugacccaggacuggauucccuuucaguuuggaggaguccgcgguggggggguggggg gggggcggaggagggacugaccacugggucccgcaggcucucacacacuccaguggauguauggcugugacaugggguccg acgggcgccuccuccgcggguaccugcaguucgccuaugaaggccgcgauuacaucgcccugaacgaagaccugaaaacgug gacggcggcggacauggaggcacagaucacccgacgcaagugggagcaggcugguauugcagagagagaccgggccuaccug gaggucgcgugaggcuccgcagauaccugcagcucgggaaggagacgcugcugcgcacaggugcaggggccgcgggcagcuc 25 cucccucugcccucaggcuggggcucaguccuggggaagaagaaacccucagcugggguggugccccuggcucagagggga gagagugacccugggucuccugaucccucaucacagugacugcacugacucucccagggcucagccuucucccuggacagug cccaggcugucucaggagggaaggagagaauuucccugagguaacaacagcugcucccuucaguuccccuguagccucugu agccauggccucucccaggccaggguucucagccuacacccacugucuguagacacugacuccuguccugcugaguguguca gcccuuacaccucaugaccugaagucuccuuuacccgaugggagacauggacaucuacacuaggcugguucccccaguuucu 30 agaacuuuccaaagaauacagucuaccagauccuucccugucugugggguuugcauccuuugacacccaauucuaucuauuc cugcaauggugaauagucacaugagccauuauggguuacccuaaacaaauacuuuucuuguguuuuuccccucucguuuuc uuuuuaucuuuacuuuuuuuuuaaggguauuauguugcuuauaaucgguuuuucuucggcacuggaaugauauugcucuc ucuccccaccauacccccacccccgccuauaucauuuguaucaguagcccuggcugucguggaacucacucuguagaccagg cuggccuugaacucagaaaucagccugccucugucucugccucugccucccaagugcugggauuaaaggcuugggccaccac 35 cacugggcagaagaaagguuccugugagcuuaaaauguuuucuggcagaauuaaccauccagaucacuccugauaucccugu gccccaccaaguuacagugcucccccuggugaaucagaacuuggacucugagagacagggucuucugcaauccaggccugag ugagagggaagaccacacacccugugagcccacuguguuccagugagugcugcacugggguccacagcacauuccagggauc cugugugacacaucuguaccuugucccccagagucaggggcugggagucauuuucucuggcugagugucagagguucacca cauuucugcuacacacucccugauggcuguuuacuuggacugacaguuaauguuggucagcaagaugaccacagugguuua 40 gucucaauggugucacucuuccaguagcauaugguccugauuucuaauuuagauacgaacucaaacacauaugaaauuucu uauuuuccauuccaucuuccauuauauagcuaccuaucucgugcuauugaacaucacauaaggaugaccauguugacccacu ggcucauguggauucccucuuagcuucugaguccccucaggaaaaugugcaguccugugcugagggggccagcucugccug caggucacuagugccaugacaguuaaaguguucauacagacacauaguucauuguaauuacugauuuagcguugucuuggc - 106aguuuucaguuugcaugcauuuauuuauuuauuuauuuauuuauuuauuuauuuaaugcauggaaguacacuguugcugu acugaugguuguuugccuuugugugguuguugggaauugaauuuuuuuuuuuaggaccucucuuugcucuggucgaccc ugcucacuccggucaacuccuaugggucaacucugcucauucagucccugcuuguucuggcccaaagauuuauuuauuauu uauuauacauaaauacacuguagcugacuucagaugcaccagaagagggcgucagaucucauuacagaugguugugagccac 5 caugugguugcuggaguuugaacucaggaccuucaaaagagcagucagugcucuuacccucugagccaucuccccaguccuc aguuugucuucuuaauugugcgauuucuugaaucuuccaaacagaucccccaaagacacaugugacccaucaccccauaucu uaugaugcugucacccugaggugcugggcccugggcuucuacccuguugacaucacccugacuuggcaguugaauggggag gagcugacccaggacacggagcuuguggagaccaggccugcaggggauggaaccuuccagaagugggcagcugugauggug ccuuuuggggaggagcagaauuacacaugccaugugcaccaugaggggcugccugagccccucacccugagaugggguaagg 10 agggugugggugcagagcuguggucagggaaagcuggagcauucugcagacucugagcuggucagggcugagagcuggga ucaugacccucaccuucauuuccuguaccuguccuucccagagccuccuccauacacugucuccaacauggcgaccauugcu auugugguugaccuuggagcuguggccaucauuggagcugugguggcuuuugugaugaauaggaggugaaacacagguag gaaagggcagggucugaguucucucucagucuccuuuagaagugugcucuaaucauuaaugggaaacccaucuacaccccac auugcuaccuucuccaacuggguccucugucaguucugggaacuuccaagaucuuccuugaacucucacagcuuuccuucu 15 cacagguggacaaggaggggacugugcuccagcuccagguuaguguggggacaggauuguccuguggacauugcagugaag cuggagauguuggggagcucugggaacccauaguaacucuuccagagaaaucuuccagggccgcaguuguccaauaugaaua cauauauguacauaugcauauacauuuuuuacccuuggcagggacagcuccuagagcucugauagaucucucccagguggu aaaggugacacucugggaccugauuggggaggggcaauguggauaugauuggguuucagggacuccacgaauccccucuga gugagugguggguuguuggaauguugucuucacagugaugggucgugucccuc uuaaaucuggagggauuuuucacacagccuaucuuuuuaggugugccuuucccauauuuu auuaaacucgaguuguuguuuuaaaaaaacagcagcauuaucaaagacacaucuguacaa acauuuuacaaaagagaacucucuaggaucagcuacaucaaggacaagcagaaaaauaga 100 A1563854 ugcaguccaacaaagacauugaaaaugacuu 101 AF017128 Sequence below. 20 ggucgcuuucugucuguagaggcggcuugccacccgagcagagggucgugaaguuccgaccggaccgguccacagaggu ucaucuggagagguggguccccuccgaggugaaaggcgccgcugagaaacgcccccaccccccgugguucaagugguuca gcccaagaacuuuucauucauaaaaaagaccagacuccgagaggcgcgagugagucagaaccgcagccgccaacgcggacc cuaccgaacauccagcccagggcauguaccgagacuacggggaaccgggaccgagcuccggggcuggcagcccguacggu cgccccgcgcagcccccgcaagcucaggcacagaccgcccagcagcaggugagacuggccgaaucgucgggggggggggg 25 accugaguuuggacagcaucagggaugcugggauuagucuaguuugcuccgggauuuggacuggggcccgagcagcau cugacucugguggucgcgaccgaggauccugcacguucuguguggucggggaaccuauguacccgguggccaaggggac gagcgcagcgggaagcgcgaauaucugcgaauuccccuucucgcucgcccguaucucccuagcugacugucuuucugccc cuccgucuccguuacggucuuacauuuccuccuaucugccccuaauacgcugucccucuaaauaccugccccaucccug cuggacaggaucagagguguucuccaucuccaguuaauaacugggaccuggggucugggcacauagagacgggguccau 30 cagaacucagccgggacagagaauucuuagcagccuguccgaggcuguccguguguugcucugguuguccgugucccuu uauccggucaaguccucaucucuuugugcgcaguauagagcccaugggccccaggcagugguuccgagggguuccugga gaccacgaaguguugggaugugcgcggggucaccugcccggccacacucgcgcuccacauucucggcacccgacgucucu cacugcuggauaggggcacuugagagguugcagguguccauuuccugucgaggggccgcgagcacgugucgccagggga gggaaggagcugcguccguuucgccgagucacagcgggccgagucacugaggcugagucacccugggugccccucccuu 35 ccuggccccaaacggccccuaaggaccgacgaccugggagcgagagaugccccuggcagugcuucuagcccagaacgggg gucacugagaugcugggucccccaguauugggcuggggacauagcuguccagacuugccuaagcaugugaggugcuucc uggacuggagggcccccacauccuuagcucacagagcuugaacccaguuuucucucccagaacgcugagcccccaccccca ccgacacucaaucccaacacaugccucagauuucugcaagaaaaggaaggaaaggaugccagaccccuuauaggaggcuuu uacucucuucacuuuauuucauggacuuaaaaaaccccaucaauuuugaacuuucaaguuuuuaagucgacagcuaggca - 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ggggcuccucggcaccgucggaggcucuggcgccagcggaguguguggggguccaggcacuggagcuuugcccucugccag 20 caccuaugcaagcaucgacuuccugucccaucacuugaaggaagccacagucgugaaaggugaggcccuuugaccuugagga ugggggagggagaguggaguauuggguggcu uuuuuuuuuuuuuuuuucagcugugaacuauuggauuugagacaggaacagaacaaaucg acgggccagaggaggguggagagagcacgagugguuuaaauaggggaggaugggagcaug gcggugggggugggggaagaguuauuuacaagaaggcucagggggccagaggcucaucuu ggaauauuuuauaacaauauauauaagauucugguuugcuuuuccuuuucgucucguaaa ggagagagaauugcauaguucgauucuguccaagggggcagcugcauauggucggccggg 110 A1834950 cgggucacuggucgu uuuuuuuuuuuuuuuuuaagugucaccacuugugacagucagcauguuacuaucagcucc agccgcagcguuuuuaaggcguuauagauuaggcaggcaauacaaggaacacgauuaaga aacugacacguaccacacgagcaauuuccagaggcuccucuucugcggugcacacguaac agugcucuuguugacauucagacaguucugagggccacucugagaggcgccuuccuguuc ucaccugacaaggauauuguuugguuugguuugguuugguuuugccuuacuauggcuuuu cuuucaacuacauuuugugucaugcuuguuagcuaacucaaauuuugucuuuguauauuu acuacuguaaaauuagaauaauuuacuguucaucucauccucugucacugauggaaccua gagacgccacaagagccacugccgugacauaccucacaagcuacaucccuguccucaaaa 111 A1851365 u cggccgcggccaccggccugcgccaagcugcugcugcggcagccaguaccucggugaagc ccauuuucagucgcgaccugaacgaggccaagcggagggugcgcgagcucuaccgcgcuu gguaucgggagcgugccgaacaccgugcacuuaaugcagcuggauaucacggugaaacaa ggacgggauaaaguccgagaaauguucaugaagaaugcccaugucacagaccccagagug guugaucugcuggucauuaagggaaagauggagcuccaggaaaccaucaaaguauggaag AW04733 cagcggacacacguuaugcgguuuuuccaugaaacagaaacaccaaggccaaaggauuuc 112 9 uuauccaaguucuauaugg 113 U06834 Sequence below. -113 gcaccugagcgcgggugccuggcgcgcccgaugggaucguugagaggcccucgacggaaagucccaaacucggaucgcauuc agccaaagugaggcggcgccauggagcuccgagcgcugcugugcugggcuucccucgccacugcuuuagaagagacccuguu gaacacaaaacuggaaacggcggaucugaaaugggugacuuacccucaggcagagggccagugggaggagcuaagcggccugg augaggaacagcacagcguccgcaccuaugaggugugcgacaugaagcgucca 5 gggggccaggcucacuggcugcgcacuggcugggucccaaggcgaggugcuguccacguguaugccacgauacgcuucacca ugauggaaugccugucccugccgagggccagucgcuccugcaaggagacauucacugucuucuauuacgagagcgaacguga 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gcugaaaugagcuauguccaccgagaccuggcugcucggaacaucuuggucaacaguaaccuggucugcaagguguccgacu uuggccucuccagauucuuggaggagaacuccucugaucccaccuacacaaguucccugggaggcaagauucccauccgaug gaccgccccugaagccauugccuucaggaaguucaccucugccagugaugccuggcgcuaugggaucgucaugugggagguc augucuuuuggggaacggccauacugggacaugagcaaccaggaugugaucaaugccauugaacaggacuaccggcugccuc cuccuccagacugccccaccucccuccaccagcucaugcuggacuguuggcagaaggaccggaaugcccggccccgcuuuccc 35 cagguggucagcgcucuggacaagaugauccggaaucccgcuagccucaaaaucguggccagggagaauggcggggccucaca uccacucuuggaccaacggcagccucacuacucugcuuucgguucuguggucgaguggcuucgagccaucaagaugggaaga uacgaggaaaguuuugcagcggcuggauucggcuccuuugagauggucagucagaucucugccgaggaccuucuccgaauu ggagucacucuggcaggacaccagaagaaaaucuuggccagugugcagcauaugaagugggaagcuaagccaggagccccugg ugggacagggggaccagcccagcaguucugaccuccaaggacucaccaccguggcagauucuucuuuccgggaggcagaguu 40 ggguggggacucacaagaugagccccucccccucgucacagccuucccauuggauugcacuuugaacagagggggucggaga cacagauuuggggaaccgugccauaugggaucauacaugugcccuccaggcggggaaccccaaacucagagugagucuuucc cucaagacugggcaaagaaacaucccuacgucucuaaccucccaucuucccagaggcucucuccccaagcgccuuccaccuca acgggcaugucccugcagaccaaagagaaagggugaccagccugccaacuugggaguggaaaaugccgucccaggaggcagga aggggcugucaggacccggugauguaaucauuggguuuugauguccugacuugcugucaccaccaaaggcaaucauuuuuc 45 ccuuguaaaugccccuccccucaucugccuucauauugaagguucugaaguuuuacuguuuuuuauuuuguuaauuuuuuc -114cuccuuccccccucccuccccuucuuguccagauuuuguguguuaaagggcaccugguuccacuaucuccuguugggaacaa ggacccaucgauauguucuagaacagugccuuggaaaugcca ggcagcgagacgagcucacggucgaggauacgggugaagcgggacaggagcaggagccgg agccgggccaaagcagaaggugcaggucggcgccggcgguugggcangacccagucaagc cggacagugaggagcggaugcagacggcacgaccauggccacgauggugcuuccucgaga ggagaagcugagucaggacgagauagugcugggcaccaaggcggugauccaggguuuaga gacccugagaggggagcaucgugcccugcuagcuccccuagcuucucaugaagcaggcga ggcugagcgggcucacaggagcgcugccuccuccugcgccgcucccuggaggccaucgag cuggggcuuggggaggcucaggugauccuggcauuaucaagccaucugggggcuguggag ucagagaagcagaagcugcgggcucaggugcggcccugguacaagagaacagugguugcg ugaggagcuggcagggacacagcagaagcucagcgcagugaacaggcgguggcucagcug 114 AA980204 gagaagagagcagcacaucu ggcagcgagacgagcucacggucgaggauacgggugaagcgggacaggagcaggagccgg agccgggccaaagcagaaggugcaggucggcgccggcgguugggcangacccagucaagc cggacagugaggagcggaugcagacggcacgaccauggccacgauggugcuuccucgaga ggagaagcugagucaggacgagauagugcugggcaccaaggcggugauccaggguuuaga gacccugagaggggagcaucgugcccugcuagcuccccuagcuucucaugaagcaggcga ggcugagcgggcucacaggagcgcugccuccuccugcgccgcucccuggaggccaucgag cuggggcuuggggaggcucaggugauccuggcauuaucaagccaucugggggcuguggag ucagagaagcagaagcugcgggcucaggugcggcccugguacaagagaacagugguugcg ugaggagcuggcagggacacagcagaagcucagcgcagugaacaggcgguggcucagcug 115 A1843232 gagaagagagcagcacaucu 116 U59807 Sequence below. augauguguggcgcgccaucugccacaaugccagccacggccgagacgcaggaggucgccgaccaggugaggcugggcccag gucaggccagucugagccaggccugcggagacccggcggccucagggaccggccugcccagacuggucagguccugcagcgg 5 guuuccggggcggccacaagugugacugggagcugggggcucuggaucugguuggaagauucagggccgggaacuggggc gagucuucugccgcuugcauacaagagggccacucaccuauuagggaacuagccccgggaucgguggagggauccgguggu cccagagaauucaggaaggcaguguuagaaccuagacggcaccuuuuugacuuacacccaggccuaaacaagagaaagccaga cugggcuacugugcuugucuccucaaaagaaagagcuaggacuguuuagcucaguggcaggaauucaacugauaccaccacc accaucaccaacaccgccccucagggaaaaaaaaaaggaucaaaaccagaaguuguagaacuugcuugugccuagucugaaac 10 gaggggguggaccuugggccugggcugcccuuccugugacuguuagcagagcagagauucaguacaagguagggggagguu caggguauuagcaagagaagaaaaguuaaacaaauccucucuucagcucuccugccacgccccaagcccaggacccuguccac uaagccuagcugaucuugggagguguuugcucugaacugaaguggccaagaaggaagugagucagcuccaugagacccuag aaaugaggaaauguuacagacacacuggccaggcaagggaaccuuggccacgugccacaucagcacucaggaggcagagacag gcgagucucucugaauuugaagccagcccaguuugcuuaguuccaugccagccauagcuacauagugagacccugucccccc 15 cccccccaaaaaaaaggagcuguguuguucuuuaucaguggggccaacaguuuaccaugucccccggaaugaggaguauuga aggcuggcagugugugugugugggggcaccugugcaugaaucuaaguccuuccuucucacccaccauccaggugaaguccc agcuugaaucgaaagaaaaucagaaguuugaugucuuuaaagccauauccuucaagagacagauaguggcuggcaccaaccu cuucaucaagguggguacugauaguagcuugccaugaacuggggacauagucucagaguagagcagaguguccugcaacuu ccugcagagaaccccuuaaggggacauguacauguucugagaggaugaauuugggguguuaggguucccggccuuaaagga 20 ggagacaaggguuaucacuggcuaaguuaguggcugguggccuguucuggcucaguuucuaaggcuggguuaagccugga acuggaaccuuaccuuucacucacaugucugucugucugucuuccuccagguugauguugguggagauaaaugcgugcacu ugaggguguuucaaccccucccccaugaaaacaagccuuugacccugucuuccuaucagaccaacaaagaaaggcacgaugag cucuccuacuucuga -115gaaaauguuaagagccaucaaauuucuggauauuuugcuaggaaaaugaaauucuacacu uauuuuuuguagacuuuuuuuaaaugcuguuuacaugaauuguauuuuggaaaaaauauu auacugugcacccugugaugcaugaagugauuuuauguauggucugcuaugugggcagag gucaccuuauuccuaugaucuggaauuguuuacuuucuacaaaguaagcuuuguggggau uuugcuuucauuuucuuuguagcugauguuauuuuaccaggugugcagcaggaauuacac 117 A1152659 cacuguguggaauuauaaauacaucccaugugca uuuuuuuuuuuuuuuuuccuggugaauauuuuuauuagaggugacaguuucccaggugac aguuuuucccaaggaagcaaaucucugcgucuauaagggaagaccacagaaccuucacuu 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acccaagaaguccaaaaacugccuguuccuuccaaaauauuggcguuucucuccuaccgc 121 AF033186 gguuag -116auggccagcuuucccccgaggguuaacgagaaagagaucgugagaucacguacuauaggg gaacucuuggcuccagcagcuccuuuugacaagaaaugugguggugagaacuggacgguu gcuuuugcuccugaugguuccuacuuugcguggucacaaggauaucgcauagugaagcuu gucccguggucccagugccguaagaacuuucuuuugcaugguuccaaaaauguuaccaau ucaagcugucuaaaauuggcaagacaaaacaguaaugguggucagaaaaacaagccuccu gagcacguuauagacuguggagacauagucuggagucuugcuuuugggucuucaguucca gaaaaacagagucguugcguuaauauagaauggcaucgguuccgauuuggacaggaucag cuacuccuugccacaggauuaaacaauggucgcaucaaaaucugggauguauauacagga aaacuccuccuuaauuugguagaccacauugaaaugguuagagauuuaacuuuugcucca gaugggagcuuacuccuuguaucagcuucaagagacaaaacucuaagagugugggaccug aaagaugauggaaacauggugaaaguauugcgggcacaucagaauuggguguacaguugu gcauucucucccgacuguucuaugcuguguucaguuggcgccaguaaagcaguuuuccuu uggaauauggauaaauacaccaugauuaggaagcuggaaggucaucaccaugauguugua gcuugugacuuuucuccugauggagcauugcuagcuacugcauccuaugacacucgugug uaugucugggauccacacaauggagaccuucugauggaguuugggcaccuguuucccucg cccacuccaauauuugcuggaggagcaaaugaccgaugggugagagcugugucuuucagu caugauggacugcauguugccagccuugcugaugauaaaauggugagguucuggagaauc gaugaggauuguccgguacaaguugcaccuuugagcaauggucuuugcugugccuuuucu acugauggcaguguuuuagcugcugggacacaugauggaaguguguauuuuugggccacu ccaaggcaagucccuagccuucaacauauaugucgcaugucaauccgaagagugaugucc acccaagaaguccaaaaacugccuguuccuuccaaaauauuggcguuucucuccuaccgc 122 Z50159 gguuag 123 X78683 Sequence below. gaauuccgugugcaaggcgaggucuguaagcuggagcggggcagaggcuggcgggcaccccuuccugaccgcuggugccgcc gccgccgccuucgggaggaucagacauggcccagaacuugaaggacuuagcuggacgccugcccgccgggccucggggcaug ggcacggcgcugaagcugcugcugggggccggggcgguggccuacggcguccgcgaauccguguucaccguggaaggcgguc auagagccaucuuuuuuaaucguauugguggcgugcagcaggacacgauccuggccgaauuucacuucaggauccccugguu 5 ccaguaccccaucaucuaugacauucgggccagaccucggaaaaucuccucccccacaggcuccaaagaccugcagaugguga acaucucccugcgugugcugucccgacccaaugcccaggagcuccccagcauguaccagcgucuagggcuggacuaugagga gcgagugcugccguccauuguuaaugaggugcucaagagugugguggccaaguucaaugccucgcagcugaucacccagcgg 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auccgggacccccacggccccuuugcagcuugccacaagguucugagccccuuggaauac uuccgccaauguguguaugacaugugugcccauaagggugacaaagccuaucucugccgu agccuggcugcuuauacugcagccugucaggcagcuggggcagcagugaagcccuggagg acagacagcgucugcccucuccaguguccugcccacagccacuacuccaucugcacccgc 126 A1465965 uccugccagggcuuccugugcugcucucucuggccucacuggcugcaccac 127 U50413 Sequence below. ggcacgagccgaguuggaggaagcagcggcagcggcagcggcagcgguagcggugaggacggcugugcagccaaggaaccgg gacagcgaagcgacggcaggucgcagcuggaucgcaggagccugggagcugggagcuucagaggccgcugaagcccaggcug ggcagaggaaggaagcgagccgacccggaggugaagcugagaguggagcguggcaguaaaaucagacgacagauggacagug ugacaggaacgucagagaggauugggccucgcugcgagagucagccuggagucaagguguugacaaguugcugagaaggaca 5 cgugggaggacgguggcgcgcggagggagagcccugucuucagucaccccguugauggaggacagauggacagcagccggac ggccagucaccucucuuaaaccuuuggauagugguccuuugugcucugcuggacaccuguuggggauuuuagcccauucuc ugaacucacuuucucuuaaaacguaaacucggacggcagugugcgagccagcuccucuguggcagggcacuagagcugcaga 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ggaagagcaccguggcugcccugcugcagaaccuguaccagcccaccgggggccagcugcugcuggauggccagcgccuggu ccaguaugaucaccauuaccugcacacucagguggccgcagugggacaagagccgcugcuauuuggaagaaguuuucgagaa aauauugcguauggccugaaccggacuccaaccauggaggaaaucacagcuguggccguggagucuggagcccacgauuuca ucucuggguucccucagggcuaugacacagagguaggugagacugggaaccagcugucaggaggucagcgacaggcaguggc cuuggcccgagccuugauccggaagccacuccugcuuaucuuggaugaugccaccagugcccuggaugcuggcaaccagcua 30 cggguccagcggcuccuguaugagagccccaagcgggcuucucggacgguucuucuuaucacccagcagcucagccuggcag agcaggcccaccacauccucuuucucagagaaggcucugucggcgagcagggcacccaccugcagcucaugaagagaggaggg ugcuaccgggccaugguagaggcucuugcggcuccugcagacuga - 120 gaauuccggggccgcucucuccggcaggaucgccgcgauggccgcccagggagagccgca gguccaguucaaggucguccuggugggcgacggcggcaccggaaagacgacauucaugaa gcgccacuugaccggagaguuugagaaggaguauguagccacccugggcguggaggugca cacauuagucuuccauaccaacagaggaccuaucaaguucaaugugugggacacagccgg ucaggagaaguucggggggcugcgcgauggcuacuacauccaagcccagugugccauuau aauguuugacguaacaucaagaguuacuuacaagaaugugccuagcuggcauaaagaucu agugcgugugugugaaaacauccccauuguauuguguggcaacaaaguggauguuaaaga caugaaagugaaggcaaaaccuauucucuuccaccgaaagaagaaucuucaguacuauga cauuucugccagaaguaacuacaacuuugaaaagccuuucuucuggcuugccagaaagcu cauuggagauccuaacuuggaguucguugccaugccugcucuugccccaccugagguagu cauggacccagcuuuggcagcacaguacgagcaugauuuagagguugcucagacgacugc ucucccagaugaggaagaugaccugugagaaagugaagcuggagcccugcgucagaaguc uauuuuaggcaacuguccugugaugccagccagcggugcagugugugugccaccuuauuu agcuaaaggagaucgugcaauucauugggaugcugaaggagaugaaugggcuucggagug aauguggcaguuaaaauacaccuucauuuuuuuggacuugcguauuuagcccccuggaac agaguuguucuggauuucaaagauaagacugcuaccguagcaucacaauagucaguggug 131 L32752 accggaauuc uuuuuuuuuuuuuuuuugauuuaugaaaaguuuuauuuaucaguacugugaagaauucuc aucauaauugcuacguuaaucaaggaaaaggcacagagaagcaugugucguuugaguccu cgauacuggaccucccagcccaugcucccuaugaggagucuagcugcugugguggucuuc acagcuuugguuuucuggagacgaagcucaugauugcguucaugcacuccucugacagcc accuugcuugcagaguagugcacucuucagcguugacugcguagagcuuuucuuucucau 132 A1840013 uuuuucugauuaacucuuuggaaauucucauuggguuuggcgggagcuucgcauau ucgggaaucgauugagagaccgcgaaccuguaaacggaugauaccgagucgggcaggcgu uaugccagcccaacucgggaccucgcaucauguccgcggcuaccuuagaguguuucggga augauuugcgguggaugaacgaaaccccgguacguccugugccaaggagcauaugucagg acggacgcucguuaaugccucagugguggggcaacguucgcucucuaucuauacgacucu cgacaauggauaucucggcucucgcaucgaugaagaacguagcgaaaugcgauacuuggu gugaauugcagaauccugugaaccaucgagucuuugaacgcaaguugcgcccgaggccuu ucgguugagggcacgccugccugggcgucacgccuuguuuugcucugugcccgugcucuu ucgggggcggucauggaugcggagauuggcccuccgugccucgugugcggcgggcuuaag cgcggggugucggcgucgggaagggcacgacgagugguggacggagcaccagcaggaugu uguggucccccgucaccuuaaggggcucaagagacccggacuaggcgagccgcgcuucgu 133 AB020424 aagaggagggcgagcugucucgcaau uuuuuuuuuuuuuuuuugaaguugcugccccuuuauuggugacccgggcaaguuuaagga gaacaacauuaaagcacacaaaguguauccaugucaccagcucaaccaggaggagugagg gucacggcaggguucucccaugguguaagaaaucaacgcaauuucaucacaccccguuac uuuccaaguuaacgaaccgauaagaaaagauucucccuuaaacugacaaguacaauguac 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agucaguccagauucugcgagacuggcuguaugaacacagauacaacgccuaucccucagagcaagagaaagcacugcugucc cagcagacacaccuguccacacuacaggucuguaacugguucaucaacgcccgccgcaggcuccuuccugacaugcugagaaa ggauggcaaagauccaaaucaguucacgauuucccgccguggggccaagauuucagaagcuagcucuauugaagcugcaaug gguaucaaaaacuucaugccaacucuagaagagagcccauuucauuccugcguaguuggacccaacccaacccuagggagacc 10 agugucucccaaaccucccuccccaggauccauuuuggcucgcccgucagugaucugccauaccacugugacugcauugaag gaugggccuuucucucucugucagccgauuggugugggacagaguacagauguaccgcaaauagcacccagcaacuuuacag acaccucucucguguacccagaggacacuugcaaaucuggacccaguccaaacccucagaguggucuuuucaacacuccuccc ccuacuccaccagaccucaaccaggauuuuaguggauuccagcuucuaguggauguugcacucaaacgagcggcagagaugg agcuucaggccaaacucacagcuuaaccguuuuuucaaacaaaacaguucuccaaaauacgguccugauugccgggggugau 15 ggcaagagaugcauuauuuuauauauuuuuuc uuuuuuuuuuuuuuuuuggugguuaucaagugcacuuuauugaauccacuguggauagau aaaugaguguuacaccugcguguagggaggggcaaggagggacgcagcugcggaggguga agcacuucaggaccggaagucggaauccucuauuaagugugaagguuuugagcguuaaga acaaugaugaugacacuaacaauggugauaacaaccaucaggaugcugaggaccaaggug cugauguucaggcacuuagcaguggaggcguaggccugggcuccagucacaucacccacc aucuuccgaucccuagacuucacggaguaggcauaggcuaugaagcccaggcagcagaag AW12539 uucaugaagaguguauugaacagggaccagaccacauggucaggcaccgacaccucucug 137 0 ggcauguugaucacaguaguucugacagaagccga 138 X05862 Sequence below. aagcuucaggauacagugcacacucguaaauaaaaacuacaggcugcugcgaauuauauuucaacugaccggagaggcaaagc cugacuguccauuaacccuuaacuuccaaacgcaaacugcuuacugcaucuuuuggcauuuuaccuuaugccuuguuagguc caaggcaagagaagcgucaucaauaaccacgcaugugcaacagcuuuuccagaggaaagguguggguggcucuuaaaagagcc uuugaguuaggagugugaguuaaacgagcucacuuggagcugguguacuuggugacugccuuggugcccuccgacaccgcg 20 ugcuuggccagcuccccgggcagcagcaggcgcacggccgucuggaucucccgggacgugauggucgagcgcuuguuguaau gcgccaggcgggaagccucgcucgcgaugcgcucgaagaugucguucacgaacgaguucaugaugcccauggccuuggagga gaugccggugucggggugcacuugcuucagcaccuuguacacguacaccgaguagcucuccuugcggcugcgcuugcgcuuc uugccguccuucuucugggccuuggugacggccuucuuggagcccuucuucggggcgggagcggacuuggcgggcucaggc auacugagaggaugaagugaacuaaguugaaaaaggauaacuaaaaguuaaugacuguucuggcugcaauuuuaaacaaacu 25 uacggcuauggcaaccugaaucaccauacgucauguacuaacaguccaaucaaaacaagggauuuucaaaccagggcgccauu gguaaccaauguguaaccaaugaaaucucuccguuuucgcguccagccuugacuauauauacuaugcguauacguuuuugcu ucuuacugcggugguuaucuacagcugaguuaugucuggacguggcaagcaaggacguggcaagcaaggaggcaaggcccgc gccaaggccaagacgcgcuccucccgggccggccugcaguuccccgugggccgcgugcaccggcugcuccgcaagggcaacua cucggagcgcgugggcgccggcgccccgguguaccuggcggccgugcuggaguaccugacggccgagauccuggagcuggcg - 122 ggcaacgcggcccgcgacaacaagaagacgcgcaucaucccgcgccaccugcagcuggccauccgcaacgacgaggagcucaac aagcugcugggccgcgugaccaucgcgcagggcggcguccugcccaacauccaggccgugcugcugcccaagaagaccgagag ccaccacaaggccaaggggaagugaaaccaaacauuacgaaucaccaaggcucuuuucagagccacucacuuucucaaagaga ccuaacacuacugggauagugcauugugggaaauacguguauuaaccuuccuccuauuuucccugcuugugguuaguucaa 5 ccccuaagccuuaggcuaagaguauauugguuuuuggaaggcaggcacccaaccucggaccuaguacauaaaacagacacauc uugaacuccaggccagccuacucugcaggacgaguuccaggacagaccggacugcacaaagaauugucuugaaauguuccuu uaucagcacauaugcugauaaacaacuaaucacuguacaaucaauccucacuugaauccuguuuauguggcaugauugacaa guccugccauuuggcaaagucaaaaucagcaaaggauguuaaagcauuuggugguaucacagcuaaaac uuuuuuuuuuuuuuuaugcaaauaguuuucaagauuuuauugcaaaccaaaauugguuua ucgcacacaaaaaaaguugugugguaaggaggaggaauuguacaggauuauaacccaugu uaauuacaguacauuaaaaugaugguuuacaaauaagccuguaaguuuaaauaucuagug uuauaacccaauguacagacuuccuuuacacgauacauacaauaaucaggaaugcaaaag aauaugaacaaagggaaaaaaaacauaaauaaugcccguuuuauaggugacauuuuaaac AW04618 aauugaaaacaccaaccggcuuugacugacaacuggggcauugguccauaaaaacccuuu 139 1 cuaaaaauagaaauau 140 U10118 Sequence below. gaggcugcucaagagcugcgguugggucaccgcuucauguuucucugccgauucuggggaaagauggcaacgaaugaugcu 10 guucugaagaggcuggagcagaagggugcagaggcggaucagaucaucgaauaucucaagcagcagguugcucuucuuaagg agaaagcaauuuugcaggcaacaaugagagaagaaaagaaacuucgaguugaaaaugcuaaacugaaaaaagaaauagaagag cuaaagcaagagcugauucuggcagaaauucauaacggaguggagcaagugcguguucgauugaguacuccacugcagacga acuguacugcuucugaaaguguggugcagucuccaucaguagcaaccaccgccucuccugcuacaaaagagcagaucaaagcg ggagaagaaaagaaggugaaagagaagacugaaaagaaaggagagaaaaaggagaagcagcagucggcagcagcaaguacuga 15 cuccaagccuaucgacgcaucgcgucuggaucuucgaauugguuguauuguuacugccaagaagcacccugaugcagauuca cuguauguggaggaaguagaugugggagaagcagccccgcgcacggucgucagcgggcuggugaaucauguuccucuagaac agaugcaaaaucguauggugguuuuacucuguaaucugaagccugcaaagaugcggggaguucugucucaagccaugguga ugugugccaguucaccagagaaaguggagauucuggccccucccaacggguccguuccuggggacagaauuacuuuugaug uuuuccuggagagccugacaaggagcuaaacccuaagaagaagaucugggagcagauccagccugaccugcacaccaaugcug 20 aguguguggccacauacaaaggagcucccuuugaggugaaggggaagggaguuugcagagcccaaaccauggccaauagugg aauuaaauaagugcucuguaacugaaagacauuggcgaaaacuuaauaacaauaaagagaaguguguuuaucacuuacauau ggccuuguuuuugguuugcaauaaagaguauuucuuuaaaaggcacauuuuguuaaauag AW21277 gcaguuccccuccugccucuuccuuuguagcaguguacugcauccuagaaacauuuagca 141 5 aagcagcccuuagccuccccgacccccuuucccucccucccagca uuuuuuuuuuuuuuuuuaaacaaugacgccguuuauuuaaaauguuuacucccagaaaua uagauauaaaaaaaaaaauaagacaauuaacagcacuaaaccaggcaccuucaaccgaau cccaccauccucguuaacucccuuccuguuacccuuuguagaugaccagaagauuucagg agccccuggacagccagagugguuccugcccagggcuucccgccuuccuccuguccuaga gcuucccgugggaaagcuugggugagaauuuuagccuaaagggagggggcuguggccggg 142 A1846302 cacuuugcgcucauccacugcagg 143 M22998 Sequence below. acaggguacaguugugcgucagggcguggaggucuggcgggagacgcauaguuacagcgcguccguucuccgucucgcagcc ggcacagcuagagcuucgagcgcagcgcggccauggaucccagcagcaagaaggugacgggccgccucauguuggcuguggg aggagcagugcucggaucacugcaguucggcuauaacacuggugucaucaacgccccccagaagguuauugaggaguucuac 25 aaucaaacauggaaccaccgcuacggagagcccaucccauccaccacacucaccacgcuuuggucucucuccguggccaucuu cucugucgggggcaugauugguuccuucucugucggccucuuuguuaaucgcuuuggcaggcggaacuccaugcugaugau - 123 gaaccuguuggccuuuguggcugcugugcuuaugggcuucuccaaacugggcaaguccuuugagaugcugauccugggccg cuucaucaucgguguguacugcggccugacuacuggcuuugugcccauguaugugggagaggugucaccuacagcucuacg uggagcccuaggcacacugcaccagcugggaaucgucguuggcauccuuauugcccagguguuuggcuuagacuccaucaug ggcaaugcagacuuguggccucugcugcucagugucaucuucaucccagcccugcuacaguguauccuguugcccuucugcc 5 ccgagagcccccgcuuccugcucaucaaucguaacgaggagaaccgggccaagagugugcugaagaagcuucgagggacagcc gaugugacccgagaccugcaggagaugaaagaagagggucggcagaugaugcgggagaagaaggucaccaucuuggagcugu uccgcucacccgccuaccgccagcccauccucaucgcuguggugcugcagcugucccagcagcugucggguaucaaugcugu guucuacuacucaacgagcaucuucgagaaggcaggugugcagcagccuguguacgccaccaucggcuccgguaucgucaac acggccuucacuguggugucgcuguuuguuguagagcgagcuggacgacggacccugcaccucauuggccuggcuggcaug 10 gcaggcugugcugugcucaugaccaucgcccuggccuugcuggaacggcugccuuggauguccuaucugagcaucguggcca ucuuuggcuuuguggccuucuuugaaguaggcccugguccuauuccaugguucauuguggccgagcuguucagccaggggc cccguccugcugcuauugcuguggcuggcuucuccaacuggaccucaaacuucauugugggcaugugcuuccaguaugugg agcaacugugcggccccuacgucuucaucaucuucacggugcuccucgugcucuucuucaucuucaccuacuucaaaguccc ugagaccaaaggccgaaccuucgaugagaucgcuuccggcuuccggcaggggggugccagccaaagugacaagacacccgagg 15 agcucuuccacccucugggggcggacucccaagugugaggagccccacacccagcccggccugcucccugcagcccaaggauc ucucuggagcacaggcagcuagaugagaccucuuccgaaccgacagaucucgggcaagccgggccugggcgccuuuccucagc cagcagugaaguccaggaggauauucaggacuuugauggcuccagaauuuuuaaugaaagcaagacugcugcucagaucuau ucagauaagcagcagguuuuauaauuuuuuuauuacugauuuuguuauuuuuuuuuuuuaucagccacucuccuaucucc acacuguagucuucaccuugauuggcccagugccugaggguggggaccacgcccuguccagacacuugccuucuuugccaag 20 cuaaucuguagggcuggaccuauggccaaggacacacuaauaccgaacucugagcuaggaggcuuuacgcuggaggcgguag cugccacccacuuccgcaggccuggaccucggcaccauagggguccggacuccauuuuaggauucgcccauuccugucucuu ccuacccaaccacucaauuaaucuuuccuugccugagaccaguuggaagcacuggagugcagggaggagagggaagggccag gcugggcugccagguucuagucuccugugcacugagggccacacaaacaccaugagaaggaccucggaggcugagaacuuaac ugcugaagacacggacacuccugcccugcuguguauagauggaagauauuuauauauuuuuugguugucaauauuaaauac 25 agacacuaaguuauaguauaucuggacaaacccacuuguaaauacaccaacaaacuccuguaacuuuaccuaagcagauauaa au ggcugguuuuuag 144 X64837 Sequence below. gcuuucuaaacuagcaagcaucguguggguccuucaggagugggagugcagacagaccugacagcguccgcuaagcgacacu gacuguacuuccacuccugaaggacccacacgaugcuuucuaaacuagcaagucugcagaccauugcugcucugcgccgagga 30 guccacaccucagucgccucugccacgucuguugccacaaagaagacagagcaaggcccaccauccuccgaguacauuuuuga acgggaaucuaaauauggugcacacaauuaccauccuuugccuguagcccuggagagaggaaaaggcauuuauaugugggau guggaaggcaggcaguacuucgauuuccugagugcuuauggugcugucagccaaggacacugccacccaaagaucauagaug ccaugaagagucagguggacaagcugacauuaacaucucgggcuuucuauaacaauguccuuggugaauacgaggaguacau caccaagcuuuucaacuacaacaaaguucucccuaugaauacaggaguggaggcuggagagacugcauguaagcucgcucgu 35 cguuggggcuacaccgugaaaggcauccagaaauacaaagcaaagauuguuuuugcugaugggaacuuuuggggucgaacac uaucugcaaucuccaguuccacagauccgaccaguuaugauggcuuuggacccuucaugccaggcuuugaaaccaucccaua uaacgaucugcccgcacuggagcgugcucuucaggauccaaauguugcugccuucaugguggagcccauccagggugaagca ggcguuaucguuccggauccaggauaccugacaggaguucgggaacucugcaccaggcaccagguccuguuuauugcugaug aaauacagacaggauuggccagaacugguagauggcuggcuguggaucaugagaaugucagaccugauaugguucuucuug 40 ggaaggcccuuucuggcgguuuauacccugugucugcagugcugugugacgaugagauaaugcugaccauuaaaccaggcga gcacggcuccacauacggcggaaacccacuaggcugccgaauugccauugcggcucuugagguuuuagaagaggagaaucuu gcugagaaugcagacaagaugggcgcuauccugaggaaggagcucaugaagcugcccucugacguugugaccucagugagag ggaaaggguugcuaaaugccauugucaucagagaaaccaaagacugugaugcuuggaaggugugccugcgacuucgagauaa - 124 cgggcuucuggccaagccaacccacggugauaucaucaggcuugccccuccccuugugaucaaggaggaugagauccgggag uccguggagaucaucaacaagacuaucuuguccuucugagaguaggaacucuggggagccaucuucagacagggcucuugug aaacucugcuugcaguggccagagccugucuccugaaaggcauauauuucaguugaugcauaauagagugacaccuaggaac cugcagguggcugcgugacagaaaagugagagcgagaggcgaggcgucucuuuguugagguuugacugugugggaacuuuc 5 uaaggagaaacggacccaucugcguacagccugcagauggaggccugcagucauuuacgugcgucuuuacaguuuccuugcu gaugugaaugguuuguauuuagaaguuauuucugagauacuacagaacaguuaaaucauuauaaucaaugaauguuaaguu gauugaagguuaagcauauguaaaauacuaguuuaaaguaaacuuuucauuggccaacaccagaauguauuauauagauucu gagaauucauuacuaaauuacacuuugcuugauugcaauuuguaaaacauuuauuuucaguauuucuuugaauaaagcuua auguuucuuuuuacgccaacagaguauuuuguauuuccauuuugguaauaaucaguguauuauuucauccugaugacugg 10 auuucaucaccuauugagaucacuggguguguuucaggccuuuuauucuaaauaaagcuaugaccaguuucugucugu uuuuuuuuuuuucuuuuccgacgcccacaagaggaauaagagauuuaaugauggaaagua uggggaaaucacaguuuucagacaugaguaaucaaaaacuugacauuuuucuugauaucc aaaucuagaugucuguaucaaaccagaggugauggccuuggggauggcagugaagacugu 145 A1843119 uaggaccauuagaucagau uuuuuuuuuuuuuuuuuacaguuuuaaaacaauacacagcuuucucgggcugaagcaauu gcaagaacguauugguauugguauauuacagcuacauacaagguuuaugaauagcaaugg agaaaaauaaguuauuuaaauauugacuucauaaagagaaagugcaauguuguuaguugu cauaucacuugcuugacaguuugugggguuucuucccuaucaauuuuaacaaucaagaua acauggacucaagacagaauuuuucgggaaccucacucaguccucacacagcagugacuu gggaaucuacguguguuccaccgcaguugugaaacacacuacuccguguccaggacucau 146 A1837786 uucucagagaagaaucaauucgaguuccauccacaccuggggucgggacaca 147 U41465 Sequence below. ccgggcucgaauucucuagacucgaguuuagagaauucgagcucucccaguuuuaaagcaaaauuuuggacugugaagcaag gcacugggcaaacacaacauggccuccccggcugacagcuguauccaguuuacccggcacgcuagugauguucuucucaaccu uaaucgccuccggagucgggacaucuugacggacguugucaucguggugagccgugagcaguuuagagcccauaagacagug cucauggccugcagcggccuguucuacaguaucuucacugaccaguugaaaugcaaccuuaguguaaucaaucuagauccug 15 aaaucagcccugagggguuuugcauccuccuggacuucauguacacaucuaggcucaaccugagggaaggcaauaucauggc ggugaugaccacagccauguaccugcagauggagcauguugucgacacaugcaggaaguucaucaaggccagugaagcagaaa uggccccugcacuuaaaccuccccgugaagaguuccugaacagccggaugcugaugccccaugacaucauggccuaccgaggu cgugaggucguggagaacaauaugccacugagaaauacucccgggugugagagcagagcuuuugcuccuccucuguacagug gccugucaacaccaccagccucuuaucccauguacagccaucucccgcucagcaccuuccucuucucugaugaggagcuccga 2 0 gaugccccccgaaugccuguggccaacccuuuucccaaggagcgugcccuccccugcgacagugccaggcaagucccuaauga guauagcaggccagccauggaggugucccccaguuugugucacagcaacaucuacucgcccaaggaggcagucccagaggagg cucggagugacauacacuacagugugccugagggccccaagccugcugucccuucugcucggaaugcuccauacuuccccug ugacaaagccagcaaagaagaagagagaccuucuucggaggaugagauugcccugcauuucgagccccccaaugcacccuuga accggaagggucugguuaguccccagaguccccagaaauccgacugccagcccaacucacccacagaguccugcagcagcaag 25 aacgccugcauccuucaggccucuggcucuccgccagccaagagccccacugacccgaaagccugcaacuggaagaaguauaa guucaucguucucaacagccucaaucagaaugccaaacccgagggcucugagcaggcagagcugggucgccucuccccucgag ccuacccugcaccgcccgcuugccagccgccuauggagcccgcgaaccuugaucuccaguccccgaccaagcucagugccagu ggggaggacucuaccaucccccaagccagccggcucaauaaucucgugaacaggucccugggaggcuccccccgaagcagcag ugagagucacucaccacucuacaugcaccccccaaagugcacauccugcggcucucaguccccacagcauacagagaugugcc 30 uccauacugcugggcccacguucccggaggagaugggggaaacccagucagaguauucggauucuagcugugagaaugggac cuucuucugcaacgaaugugacugccguuucucugaggaggccucgcucaagaggcacacgcugcagacgcacagugacaaac cauacaaaugugaucgcugccaggccuccuuccgcuacaagggcaaccucgccagccacaagacuguccacacgggugagaaa - 125 cccuaucgcuguaacauuuguggagcgcaguucaaucggccagccaaccugaagacccacacucgaauucacucuggagaaaa gcccuacaaaugugaaaccuguggggccagguuuguucagguggcccaccuccgugcccacgugcucauccacacuggagag aagccguaccccugugaaaucuguggcacucgcuuccggcaccuucagacucugaagagccaucugcgcauccacacaggaga gaaaccuuaccauugugagaaguguaaccugcacuuucgucacaaaagccaacugcgacuucauuugcgccagaagcacggcg 5 ccaucaccaacaccaaggugcaauaccgcgugucggccgcugaccugccuccggagcuccccaaagccugcugaaugaagcau ggaguguuccucgcccuuuccucuccagccccuucucagaaucuacccaaaggaugcuguaacacuuuauacaaaggucauc ccaugauguagugccucucucauccacuagugcaaaucauaguugggguggggguggg ucgcgguccgacggaggagugggcgcugggaucucgcugagcguccgccuggccucgucu cuuccucgcucgucggagcuucagcacgguccgagauggcuggcgguaaggcuggaaagg acuccggaaaggccaagacaaaggcgguuucccgcucgcagcgagccggcuugcaguucc cugugggccguauucaucgacaccugaaaucuaggacaaccagccacggacgugugggcg cgaccgccgcuguguacagcgcagccauccuggaguaccucaccgcagagguacuugagu uggcaggaaaugcgucaaaagacuuaaagguaaagcguaucaccccucgucacuugcagc uugcuauacguggagaugaagaauuggauucucugaucaaagcuaccauugcugguggug gugucaucccacacauccacaaaucgcugaucgggaagaaaggacaacagaagacuguuu aaggaugccuggauuccuuauuaucucaggacucuaaauauuccuaacagcuguccagug uuggugauuccaguggacuguaucucugugaaaaacacaauuuugccuuuuuguaauucu auuugagcaaguuggaggcuuaauuagccuuccaaccaaccaaauuucugcauucgaguc uuaaccauauuuaaguguuacuguggcuucaaagaagcuauugauucugaaguagugggu uuugauugaguugacuguuuuuaaaaaacuguuuggauuuuaauugugaugcagaaguua uaguaacaagcauuugguuuuguacagacauuguuuccacucugguggauaagcucaaua aaggucauaucccaaacuagcuuuaaacuugcuuaauaaucgggucuuaccuuagaucuc acucagcaacaaguacauucucugcuuacuaauuaaacagugcaucuguagucauaaaaa 148 U70494 aaaaaaaaaaaaaaaaaaaaaaaaaaaaa 149 D17666 Sequence below. caccaccgugcacgcagcuccgggcccgugggguguugguucuugcccucguaacccccucuguccagccaccaugauaagc gccagcagagccgcggccgcgcgucucgugggcaccgcugcgucccggagccccgcagccgcccguccccaggugagaagcug 10 ccaugccuuccggugggggcuccaggcccggacucgagugaggcaggccuugccuucgggucagacucuaggaaaaauccgg agcgaagggauguaacggaccuucugugggcauuguuggccuucuugcagggcuuuagcuucgaacugugcugagucacaa uccuuggcguuccuaagucuuuaccccgcuaauugagacgucuguccccccucuaaccugugcgcuuugaaugugccuggac uuaggcaguggacguaguuuacuggaaannnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnuuuuacauacuaaggacuaaagcuugca 15 uguguuccucagaauaugaaaagcccaaguucuuguguaguugauggcugaugcaacuuuuuuccccccaggauggcugga auggccuuagccaugaggcuuuuagauuuguuucaagaagagauuaugcguaaguacaaccucaguuucucugagaaaaaaa aaaaacacuuauugaaccucaaagcuuggauggguugggugcguuauacauuuguacuuguaguuuauucaauaugccacu gguaacaccaacauaaaacacaguucuucguauuggagaccacuguucagaugaccauggaauuucauuucuuacagaucag aagcaaucaagggugcagugguugguauugauuuggguacuacuaacuccuguguggcuguuauggagggcaaacaagcaa 20 aggugagcaugauuggaaaccugaggucacuuagauacccagucuggcauuaaguacauaggaaugcugagucggagcccag guuaguggugggcacuuuaauccuaguaaaggcagagggaucucugaguucaggaccagccuagaguacaaagugagnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnacuuuaaucagugucuuugggaauuuuagguccuggagaaugcugaaggugccagaacua ccccuucugugguugccuuuacagcagauggagaacgacuuguugguaugccagcaaaacggcaagcugucaccaauccaaa 25 caauaccuucuaugcuacuaagcgucuuauuggacgacgauaugaugacccugaaguacagaaagacacgugaguaauagga aaaucaguccagaagacuggugcuuugaucaaaguucuguggauaccuugaguucuguggaucaccuuggaucacuuuuuc - 126 auuauuucugcuugggaagaaaucacaccaccaucagaggcauauagguuuuuuuuuuguuauuucuuuguuguuguugu uuuccuauuuauuuguuuguuuguuuggggggggguuucuuuguguauuuuccuggaacucauucuguagaccaggcugg nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnucaugugauauaugaugaacuuagagugguuaaguuucacagggauaguuuacuu 5 acauaaucuuucugucuuuaaguaagaauguuccuuuuaaaauuguccgugccuccaauggugaugcuuggguugaggcuc auggaaaacucuauucuccaagucagauuggagcauuuguguugaugaagaugaaagagacugcagguaaguggauuuauu ucacauuuaggaaaauuggaaugugcuguuuauuucucugcauuaauacugauuaacuucauauucuguagauaauggagu cugaagcuunnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnngaauucaugcuccuccugcugccuccugggugcuaaguugcaaggug 10 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cuauggugcaacugggcaucugugcuuuccgccaaggccugacaaaggaugcacacaauggcacuucuggauauucagucaa gugguggugccaaggagcuucuaggucaggguuugcugcugcgcgcuugcaggagcgaaaucaggaacaggaaaagguagag cgacgccggcaggugcccuuucaccugcacaucaaccuggagcugcuggagugugucuaucuggugucagcuaugcuccugg agauccccuacauggcugcccaugagagcgaugcccgccgacgcaunaucagcaagcaguuccaccaccaacugcgggugggc gagcggcacgcccugcuagguccucccgagucaaugagggagcauguggucgcugccuccaaggccaugaagaugggcgacu 30 ggaagaccugccacaguuucaucauuaaugaaaagaugaaugggaaagugugggaccuuuucccugaggcugacaaaguucg caccaugcuaguucggaagauccaggaagagucucugaggaccuaccuuuuuaccuacagcagugucuaugacucaaucagu auggagacacuaucagauauguuugagcuggaucuacccacuguucacuccaucaucagcaagaugaucauuaacgaagaau ugauggcuucccuggaccagccgacacagacuguggugaugcaccguacugagcccucugcccagcaagaaacuuggcucug caagcuggcugagaaaacuuggcacccuaguggagaauaauggacggguguuugaccaaaaacagggaaccuaugguggcua 35 uuuccgagaccccaaggguggcuaccggaaaaauggaggcuaaaugccccgugguggcuacccccagcaacagucucagacaa ccuccugaguuccccacuucagucacccuguggacagaccaucuaaccuuuuucuccuaacucaccccaaucauuaaagaucu - 130uuugaggaauuaaaaaaaaagaaagaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa uuauuaauuaaaaaacaauuuauugaaaaagaguagugcuuuguacaaauucccauugca gcccccagauaucaacugaucucuuuccagcuuugguaguaggguauaaaaauaucaaaa cuagguaaguucugauguaagauuucuaugggauuauuuuagaauauauagauuugugua guuuggcaaguaucauuucuaugcauuuacauuacauauuaagcacagauucuguggcaa aacaucuuugcaugauuacuuuacacacacaaauauaguaaaacuuacauaguacaaauu cacauaagacuccauucugucuauaacuucauccaugugguuuuaccaugaauuauaauu cuuaaccucuccuauaacugucagcuuccauuuaauuuugaaaguaucacuucacaaaga 155 A1604314 gcacuucauuugcuuuuagaguauacauagacu cggccgccaagaaguauaacaugcgaguggaagacuacgagccauaccccgaugauggca ugggguauggcgacuacccgaugcuccccaaccgaucacagcaugagagggauccguggu aucagugggaccacucagaacucaggaugaacuggggugaaccgauacacugggaccuag acauguacaucaggaaucguguggacacgucaccuaccccuguguccugngaugucaugu guaaacaucucuucggcuuuguggcuuucaugguuuucauguucuggguagggcacgugu ucccuuccuaccagccuguggguccgaagcaguacccuuacaaaaaucuguaccuggagc 156 A1845121 g uuuuuuuuuuuuuuuuugaugcaaaugucuuuauuuuccacuuaaacaaguuucccuuuu gcacuggccuguggcacaaaacagauggcuggguggugacauuaacugucaaguuaguga gaugcagagauggugagacacugcauuugagugcauaauacuuuuauuccagaggaacgc caugcagcccaguuacaccuuuaggucagaaaggcugaugcgugaccagccucuauugcc ucccuugguaagaaggacccacaagugcagaguccaacagaugcuggcucugagcugaac ucagggcauuccaauuaccacuuucuucuucaccuacacagggccugcucagauguccuu AW04775 uuuacaacuccauaagcccuuuggccaaagucccugcaguguuuggggaggaccuuccca 157 6 cccuucaccagucagugucugaucugguggag uuuuuuuuuuuuuuuuuaauaucuguaauaguuuauuucaaagauuugacauuuacaagu agaggcaccacaugcuaucugacaguaaaauacugcagggacugaaggccaaggagagag auccacagaagacaggccuguagugcaggcauugcaucgaccuugcccacagugcuuugu ucccaacucaggacaguacuuuagugcuugcuucauuuacuggaaaaguucacuggacau aguuuccacuucuucccccacagcuuccagcucagcaaacuuaagcuacuacuccucgau gcucucauagaggcucuugauuugugucuggaagaacuuggcaagcucuacucguuuggc 158 A1838021 uuucagugucggugucagaaguccguuuucaa uuuuuuuuuuuuuuuuucugagguauuaaaauaucuagacugaauuuugccaaauguaag agggagaaaguuccugaagacucugacuacuugcuuauuuuugauugaccuucuaugcuu AW12289 augucauuacugccucacaacguguuugauguccuuuaaugauacaaagugagccugugc 159 3 cuucauuuucuugcccauuuugguaccccucgugccg 160 M59821 Sequence below. gcgcccgaacgucuagcagaguaccugcugcuguaagcuugucgucugggcugcaccgcccgucuuaacccauucucgacuu aacuacucucgucgaacaagcauggaaguacagaaagaagcgcagcgcaucaugacucugucgguauggaagauguaccacuc ucgcaugcagcgagguggcuugcgacuccaccggagucugcagcuaucccucguuaugcgcagcgcucgagagcucuaccuc 5 ucagccaagguagaagcccaccagcccgaguucccgccaucccgcagggcucuugacccucgccugcacccgccgcgggaag cgaaguugcaguggaaguagcgucccccgaagccgugcagccuccggagcccauggauacgcaagaggaagugcugcgagucc aggagaccccugcgcucugugacccgccccccgcuagagucagccgcaagcgccggagcagcagcgauuugagcgacaguagu gaugccggacugguaccaagcaagaaggcccgucuagaagagguggagggggaggcgacgucggagguucccgaucgccugc agcuuccuccggcacaaagcgaaggugccuucccuaaccucgcccgcguccuccaaaggcgcuucuccagucuccugaacugu - 131 ggacccgccgugcccccgccgacgccccccacgugcgaggccaagccagccugccgcccggccgacaauaugcucaacgugcu ggugcgagcugugguggccuucugagagcucugguggcuucuuucgagcggcgccaccggagcggagaacgcacacccgagg cgaaggccggcgggggccgugaagaagagccgcggcccgagcugccgagaggccagggcaaggacugaggagcgaggggcgcg ggcgccuucucccagacgugcguccauaggugcuauuaaaggacugucccuuccuuggcuuggagaagggacaccuagaucu 5 ugaaucucagggucgaacucucuaggggccaggcugcccuuucaaggccguuucacuaccauucgcguuucggccccuacaa gugggcacgcuugugcaagcggucagaguugcgucaugggacagacgcgggugcuuccuguugccuugcgugggugugggg ccugggaggaggccaggguguggacccgcccuagggacugggaagugacuugagucaccucgcccccacaggcugcuguggg ugagccugaacugaaccaaucaaaucugcgcagaguugaaguggcuggagaccccgggacuggucaaccuagaugaucgccu ggcguggaccaccgcgggacgggugggccgcuggucguaguugcugccguagacacagcuucuucgggcaggaaagaaaauu 10 uuuuuuuuaccagcguguuuaagaaagucuguuuacuuuucccacgguggguuguuuaauuagcaacuaccuggaguuuua caaugucagcuaggaaaauaaagaccaucggugu 161 M13805 See above (same Accession Number). uuuuuuuuuuuuuuuuugguuccacuuaaguugcauguuuuauuucucccaaucccagca auagcacagaagcccaucauguccaucccagacugguuucuaguaggcugagaugacagg gagccucaguaacgcuaauggcacagagggcucccaaaugccaggcacaacugugccucc acacuggugacugcccagagugcccuggccccaguguguuggcacucagucugacuuuac aacgcaaccugcaccuuugaaagggacagucugggaguggggagugugagggagugaagc ucaaacugccuccugucagcucacccuuucaacauuaaacagagaccaagagagaaacag uuccaauauuucacauauauuucuucuugugcagucuaagccgagaaugccauguaaaug 162 A1845886 ggucacugcgaaaugcagcaauuuagu gucucgggcgagauggcuucaagguuacuucgcggagugggcgcuuuggcggcgcaggcc cugaggcgcacggcccguggcgcggccgugacccgcuccauggcuucuggaggugguguc cccacugaugaggagcaggcuacugggcuggagagggagaucaugauagcagcacagaag ggacuggacccauacaauaugcuaccuccaaaggcagcuucaggcaccaaggaagacccu aaucuagucccguccaucagcaacaagagaauagugggcugcaucugugaagaggacaac uguacugucaucugguuuuggcugcacaaaggcgagagucagcgaugccccaacugugga acccauuacaagcuggugccccaccaaauggcccacugagccccuguguuaucuuuucag 163 X53157 aauguaaagaaaaacuucucucuaauaaagacuagccauugcaccugcuccuccc 164 U19118 See above (same Accession Number). 165 AF062071 Sequence below. gcgcaccgccygyguygcgcgscagcgucgucuaggugcaucgcgggcccccgcagrwagaaaaauauggcucaggagacuaa ccagaccccagggcccaugcuguguaguacaggauguggcuuuuaugggaauccuaggacaaauggaauguguucuguuug cuacaaagaacaucuucagagacagcagaauaguggcagaaugagcccaauggggacagcuagugguuccaacaguccuaccu 15 cagauucugcaucuguacagagagcagaugcugguuuaaacaacugugaaggugcugcuggcagcacaucugaaaaaucaag aaaugugccuguggcugccuugccuguaacucaacaaaugacagaaaugagcauuucaagagaggacaaaauaacuaccccga aaacagaggugucagagccaguugucacucagcccaguccaucaguuucucagcccaguucuucucaaagugaagaaaaagcu ccugaguugcccaaaccaaagaagaacagauguuuuauguguagaaagaaaguuggccuuacaggguuugacugccgaugug gaaauuuguuuuguggacuucaccguuacucugacaagcacaacuguccauaugauuacaaagcagaagcugcagcaaaaau 20 cagaaaagaaaauccaguuguuguggcugaaaaaauccagagaauauaaaauuacuacaugugaagagacugaaacuuuguu uuuauuuuaauauaucguaggaaaacauuaaagagcagaugcauggccauuuuccuuugauguucuccagaguuuugcuuu auacuugucugucauauaauugaucuuuuaggauguuuggguguuuguuacaggcagaauuggauagauacagcccuacaa auguauaugcccuccccucaguaaaauuggacaaaaauaugcacaacaaauugaaauacacauauacuaggaacaaaauuuag uuccacgugccaaacuaaaggaaugaaaucucugcauguuugcagcauaucugccuuuugggaauguaaucaagguauaauc 25 uuuggcuaguguuaugugccuguacuuaaaaaaaaaaaaaugguacaccagaaaaggacuggcagucuacuaccauagucaa - 132acuucaccuuaauuucgacaugacuuuuggaagcaggaagaaagcuacaaaacugguauuugguaccaugugugagccuggu uaaauuggucuucuaaaagcugucaauuaggacauucugcgaaagguaacaucacaacugguucuaagucaaaccaucaagu caacagcagggugccugagauaaucuuggaagcuuauugugcuggccugcaccagaagauaucugcauucucauuacuaaaa uuguagcacagaacugcacuaggauuuguuuacaaggagaaauuaaacucuguuugguuuucacauauagcagcucuguua 5 aauaacaugcaucugaauuuuaaguugcaaagguaucugaacaguuaauuuuucaugugcaucuuuuguugaauguuuugg uucaagaaagaauguuuaaagcuuuuuaaagacuucaguucuuaauguaacuguacccuucugcauggaaaaucauaaccaa cauggcugcaguagacuucuuuagugguauccagcaccacuugcagagggcugcuuuaucauauuguacuuggguguagga cucuaguguucuuggguguauugcaugggcugcauuaucuacagcauuguacaauaacaacuagaaaaggcgguauacuuca cugaugcuugucugguaauaucacuucuguguuaaaauggaagguuuuuugugauguaugaaacuuguguuuuuuauaua 10 uaaaugaguauaguuagauuaguguugugguaaugccuguuuucaucuguaaauaguuaaguauguacacaacaaggcacu acuucugauuuuugcaguguucaguccuaguuuuucuuuauuaaaacauugaguuuugcuucaauuuuauguaccuuagu ucuaaguuagauuugcagauguguacagauaguucauauuuauguauugcacauaaucaugcuauucagcauugaugcuau auuguauuauguaaauaauaaaagcaguguacagagggaaaa augacagaugccgcuguguccuucgccaaggacuucuuggccgguggaguggccgcagcc aucuccaagacagcgguagcacccaucgagagggucaagcugcugcugcaggugcagcau gccagcaagcaaaucacggcagauaagcaauacaagggcaucauagacugcgugguucgu auccccaaggaacagggaguccuguccuucuggcgugggaaccuggccaaugucaucaga uacuuccccacccaggcucucaacuuugccuucaaagauaaauacaagcagaucuuucug ggugguguggacaagaggacccaguucuggcgcuacuuugcagggaaccuggcaucaggu ggugccgcuggggcuacauccuugugcuuuguguacccucuugauuuugcccguacccgu cuagcagcugaugugggcaaagcuggagcugaaagggaauucaaaggccuuggugacugc cugguuaagaucuacaaaucugaugggauuaagggccuguaccaaggcuuuaauguguca guacagggcauuaucaucuaccgagcugccuacuuugguaucuaugacacugcaaaggga augcucccagaucccaagaauacucacaucuucaucagcuggaugauugcacagucuguc acugcugucgcuggccugacuuccuauccuuuugacacgguucgccgucguaugaugaug cagucuggacgcaaaggaacugauaucauguacacaggcacgcuugacugcuggcggaag aucgcgcgcgaugaagggagcaaggcuuuuuucaagggcgcaugguccaacguucucaga 166 U10404 ggcauggguggcgccuuugugcuugucuuguaugaugagaucaagaaauacacauaa 167 U07634 Sequence below. cguagaaguugucucugucggcgggcgggcgggcaggauuggggcaccgagaccggcgugcggacagcagggaucgcgggga 15 gcgaggggugcggcauggagcuccgggcagucgguuucugccuggcgcugcugugggguugcgcgcuggcggccgcggcgg cacagggaaaggaaguuguuuuguuggacuucgcagcaaugaagggagagcucggcuggcucacgcaccccuauggcaaagg gugggaccugaugcagaacaucauggacgacaugccuaucuacauguacucggugugcaacgugguauccggcgaccaggac aacuggcuccgcaccaacuggguguaccgggaggaggccgagcgcaucuuuauugagcucaaguucacggugcgagacugua acagcuucccggguggcgcccaugccugcaaagagaccuucaaccucuacuaugcagagucagauguggacuauggcaccaac 20 uuccagaagcgccaguucaccaagauugacaccaucgccccugacgagaucacggucagcagugacuucgaggcucgcaacgu caagcugaacguagaggagcgcaugguggggccccuuacccggaagggcuucuaccuggccuuccaggacaucggcgccugc gugcggcugcucuccguucgcgucuacuacaagaagugucccgagaugcugcagagcuuggccugcuuccccgagaccauug cugucgcuguuuccgauacacaaccccuggccacgguggccgguaccugcguggaccaugccguggugccuuaugggggcga gggggcucucaugcacugcacgguggauggcgaguggcuggugccauccgagugccugugccaggaaggcuacgagaagguc 25 gaggaugccugccgagccuguucuccaggauucuucaagucugaggcaucugagagcccuucccuggaguguccagagcaua cccugccauccacagagggugccaccuccugccagugugaagaaggcuauuucagggcaccugaggacccacuguccaugucu ugcacacguccacccucugccccuaacuaccucacggcaugcaugggugccaaaguagaacugcguuggacagcucccaagga cacugguggccgccaggacauugucuacagugucacuugugaacagugcugcgcagagucuggcgagugugggcccugugag - 133 gccacggugcgcuauucagaaccuccucacgcccugacccgcacgagugugacagucagugaccuggagccccacaugaacua uaccuucgcugucgaagcacgcaauggcgucucaggccuggugacuagccgaagcuuccggacugccagcgucaguauuaac caaacagagccccccaaagugaggcuggaggaccgaagcaccaccucccugagugucaccaggagcaucccggugucacagca gagccguguguggaaguacgaagucaccuaccgcaagaagggggaugccaacagcuauaauggccgccgcacggaaggcuucu 5 ccgugacccuggaugaccuugcuccggauaccacguaccuggugcaggugcaggcauggacgcaggagggccaaggagccgg cagcaaagugcacgaguuccagacgcuguccacggaaggaucucgcaacauggcggugaucggcgguguggcuguagguguu guuuugcuucugguacuggcaggaguuggccucuucauccaucgaaggaggaggaaccugcgggcucgccaguccucugag gauguccguuuuuccaagucagaacaacuaaagccccugaagaccuauguggauccucacacuuacgaagaccccaaccaggc uguacucaaguuuaccaccgagauccacccauccuguguggcaaggcagaaggucauuggagcaggagaguuuggagagguc 10 uauaaagggacgcugaaggcauccucggggaagaaggagauaccgguggccaucaagacacugaaagcgggcuacacugagaa gcagcggguggacuuccugagcgaggccagcaucaugggccaguuuagccaccacaauaucauccgccuggaggcggugguc ucuaaauacaaacccaugaugauuaucacagaguacauggagaauggagcgcuagacaaguuccuuagggagaaggauggug aguucagcguacuucaguuggugggcaugcugagggguaucgcauccggcaugaaguaccuggccaacaugaacuacgugca cagagaccuggcugcccgcaacauccucgucaacagcaaccuggugugcaagguguccgauuuuggccugucgcgugugcug 15 gaggaugaccccgaggccaccuacaccacaaguggcggcaagaucccuauucgauggacagccccagaggccauuuccuaccg caaguucaccucagccagcgauguguggagcuacggcauugucaugugggaagugaugacuuauggcgaacggcccuuacug gaacugucaaaccacgaggucaugaaagccaucaacgacggcuuccggcuccccacgcccauggacugcccuucagccauuua ccagcucaugaugcagugcuggcagcaagagcgcucccgccggcccaaguuugccgacaucguuagcauccuggacaagcuca uccgacgccccgacucccucaagacgcuggcugacuucgauccccgaguguccauccggcugcccagcaccagcggcucggag 20 ggaguccccuuccguacgguguccgaguggcuggagagcaucaagaucgaacaguacacggaacacuucaugguggcuggcu acacggccaucgagaaggugguacagauguccaacgaagacaucaaaaggaucggagugcgucuuccuggccaccagaagcgc auugccuacagccugcugggacucaaggaccaggucaacacaguggggauuccuaucugaguccauuggggcugucacacaa uacuugaagagccacaguggucucccugccgaucuggugcuggcccacuggaacuuuauuuauuucuguuuccucgucuau gccucccuaggacucugcaggggcuuuuugaaugacaccugccugagccugggaaacuuggauugcuggucagggcucucu 25 uuccccugaaaaggacccagcuaagaacuuagcaguuugccauggccuucccagcauccccugaggcuaaaguuccaccaaga gucgauaucgacgagggacauuuccaaacggaccuccccaucuucauuuggccuccugagaagccacucuggagcugaggcu aagcacuaagcccaggaccauaugacuagcacuguaccgcccgccccuaguuagaggguagguuuuggacuuggcuggguug uggucacaagcaaucucccagugccuuuuacagaccccagucugcccucccgucgagggccagcuucuugcuuuccuagggc ccucucaggaugcuuggcugugcugagguuuuuauuaaauauauauuuuauacuugcggaaagaaugaguguguggcaggg 30 acuugccagggcuggagacagaggauccccugcaacaagacauucccgggcugggggcuggcggaccugcaggagacuuucc gccaccaccccgucuccagccccuuuggacaaaugucgcugucaguguuacagauuucuuuuauuggguuguuuuuuuguu guauuuuuuugaaccuuaacuuauuauuuuuuuuauauuuauuguuagaaaaugacuuauuucugcucuggaauaaaguu gcagaugguuca 168 X04663 Sequence below. ccaaaaaccuuaauuuucuuucuuguucgguaccuacauuggaaccaccaaaaacaauuauuucaguaaaccguagccauga 35 gggaaaucgugcacauccaggccggacaguguggcaaccagaucggugcuaaguucugggaggucauaagcgaugaacaugg caucgaccccaccgguaccuaccacggugacagcgaccugcagcuggaccgaaucucuguguacuauaaugaagccacaggug gcaaguaugucccucgagcuaucuugguggaucuagaaccugggacuauggacuccguucgcucagguccuuuuggccaga ucuucagaccagacaacuucguuuucggucagucuggggcaggcaacaacugggcuaaaggccacuacacagagggagcuga guugguugacucugucuuggauguggugcggaaggaggcggagagcugugauugccugcaaggcuuucagcugacccacuc 40 acuggguggaggcacuggcucuggcaugggcacccugcucaucagcaagauccgggaagaauauccugaccguaucaugaau accuucaguguggugcccucgcccaaagucucugauaccguggucgagcccuacaaugccacccugucuguccaucaguugg uugagaacacggaugagaccuacugcaucgacaacgaggcccucuacgacaucugcuuccguacccucaagcucaccacgcca accuacggagaccugaaccaucucgucucggccaccaugagcggcgucaccaccugccuccguuucccgggccagcuuaaugc - 134ugaccuucgaaagcuggcugucaacauggugccauucccacgucuccacuucuucaugccuggcuuugccccucucaccagc cguggaagccagcaguaccgggcccucacugugccugaacuuacccagcaggucuucgaugccaagaacaugauggccgccug cgacccgcgccacggccgguaccucacaguugccgccgucuuccguggacggauguccaugaaggagguggaugagcagaug cucaacgugcagaacaagaauagcagcuacuucguggaauggauccccaacaaugucaagacagcugucugugacaucccacc 5 gcguggccucaagauggcagucaccuucauuggaaacagcacagccauccaggagcuguucaagcgcaucucugagcaguuu acggcuauguuccgccggaaggcuuuccuccacugguacacgggugagggcauggacgagauggaguucaccgaggcugaga gcaacaugaacgaccuggugucugaguaccagcaguaccaggaugccaccgcggaagaggaagaggauuucggagaggaggca gaagaggaggccuaacggcagagagcccugcaucagcucaggcugcuuagaucccucagccuuucuccaacugcccuuuguc cuccaguuucuuucugcugccucugucuuguauuuguuuugcuucuguuuucucauuggggguaaauggugccuggcaca 10 uggcaggcacucaauaaauauuuguuugugg 169 X61232 Sequence below. ggcagacaaaagaggccggcagugcagcucgcgggacgcauggccgggcgcggaggacgggugcugcuggcgcugugugccg cgcugguggccggcggguggcugcugacgcgugaagcccaggagcccggggcgccagcggcuggcaugaggcgccgccggcg gcuccagcaagaggacggcaucuccuucgaguaccaccgcuauccagagcugcgcgaggcgcuggugucgguauggcugcag ugcaccgccaucagcagaaucuacacagugggcgccagcuucgagggccgggagcuccuggucaucgagcugucugacaaccc 15 cgggguccaugagccgggugaaccugaauuuaaauacaucgggaacaugcauggcaaugaggcgguuggacgggaauugcuc auuuucuuggcccaguaccuguguaacgaguaccagaaaggcaaugagacaauugucaaccugauccacagcacccgaauuca uaucaugcccuccuugaaccccgacggcuuugagaaagccgcauggcagcccgggcagcugaaggacugguuugugggccgc agcaacgcccagggaauagaucugaaccguaacuucccagaccuggacaggaucguauauguuaaugagaaagaaggcggucc caacaaccaccugcugaagaaucugaagaaaauuguggaccaaaauucaaagcuugcccccgagaccaaggcugucauucacu 20 ggaucauggacauuccauuugugcuuucugccaaucugcacggaggagaccuuguggcuaauuacccauaugaugagacacg gagcgguacugcucacgaauacaguuccugcccugaugacgcaauuuuccaaagcuuggcucgcgcguacucuucuuucaac ccagucaugucugaccccaaucgaccucccugcugcaagaaugacgaugacagcagcuuugaugauggaacgaccaauggugg ugcaugguacagcguccccgguggaaugcaagacuucaauuaccugagcagcagcaacugcuuugagaucacuguggagcuu acgugugagaaguucccaccugaagagacucucaaaagcuacugggaagauaacaaaaacucccucaucaacuaccuggagca 25 gauacaccgagguguuaaaggguuuguccgugaccuucaggguaacccgaaugccaacgcaaccaucucuguggaugggaua gaccaugaugucaccucggcuaaggauggggauuacuggcgauugcuugcuccuggaaacuauaaacuuacagccuccgauc cuggcuaccuggcaaucacaaagaaaguggcaguuccuuuuagcccugcuguugggguggacuuugagcuugagucuuucu cugaaaggaaggaggaggagaaggaagaauugauggagugguggaaaaugaugucagaaacuuugaauuuuuaagaaaggcu 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caggguugagagcaagaaggugcaggauguaggccagcagaauuaucagacccaguggcggcuucugccacuggaagaauuu ccaacauaaaacagaugaucaguuugggacaaucgauucugcgaccagagguagugucaucugguuacuuuuaaaauucaga 25 uugucugguguuuuccaaucacucgcgacuguaauuugaaguuggauucugagauaauacaaucgcugucgcucuaguuua uaaagcuguccaagaucugcccagucccagauguccuggguccucagggcggcuguggucugcgcccuucuccugcagcugg augccagaccauccuggacucggaucccuuuggguucacacucgcuuagguauuucuacaccgcugugucccggccuggccu uggggagcccugguucauaaucgucggcuauguggacgacaugcagguccugcgcuucagcagcaaggaggagacuccgagg auggcacccuggcuggagcaggaggaagcagaugacugggaacagcagacucauauagucacaauucaaggacagcugucuga 30 aaggaaucugaugacccugguucauuuuuacaacaagagcauggacgacucucacacacuacaguggcugcaggacugcgau guggagccagaucggcaccugugucucugguacaaccagcucgccuaugauagcgaggaucuccccacccugagcgaaaaccc aaguuccuguacagugggaaacagcacuguaccucagaucucucagcaccuggagggccacugcucagaugugcugcagaaa uaccuggaaaaagggaaggagaggcugcugcguucagaccccccaaaggcacaugugacccgucaccccagaccugaagguga 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auuuggcuccgaggccaagaauucggauccaaggcgggcgcggggaaaauggcggcggcagcugcggcgggggcgaauggga gcggaggcagcagcggcauggaaguggaugcagcaguccccagcgugauggccuccggagugacugggaguguuuccgucgc ucuucauccccuugucauccuuaacaucucagaccauuggauccgcaugcgcucccaggaggggcggccuaugcaggugauu ggggcucugaucgggaagcaggaggggcgaaauaucgaagugaugaacuccuuugagcugcugucccacaccguggaagaga 5 agauuaucauugacaaagaauauuauuacaccaaggaggagcaguuuaaacagguuuucaaggagcuggaguuucuggguug guauaccacaggggggccaccugaccccucagacauccacguccauaagcaggugugugagauaauugagaguccgcucuuu cugaaguugaacccuaugaccaagcacacagaucuuccugucagcguuuuugagucugucaucgauauaaucaauggagagg ccacaaugcuguuugcugagcucacuuacacucuggccacugaggaagcugaacggaucgguguagaccacguggcccggau gacagcaacaggcaguggggagaacuccacuguggcugaacaccugauagcucagcauagugccaucaagaugcugcacagcc 10 gugugaagcucauuuuagaauaugucaaggccucugaagcaggagagguucccuucaaccaugagauccugcgggaggccua ugcccuaugucacugucucccaguucucagcacugacaaguucaagacagacuuuuaugaucaaugcaaugacguggggcuc 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D20333 uaaaaauaaaguauuuugcuaguauggaaa aguccgcgucccggcgucggcccgucccgcaccauggugacgcucgccgagcugcuggcg cugcuggccgcgcugcuggccacggccucgggcuacuuugucagcaucgacgcgcacgcc gaggagugcuucuucgagcgggucaccuccggcaccaagaugggccucaucuucgaggug gcggagggcggcuuccuggacaucgacguggagaucacaggaccagauaauaaaggaauc uauaaaggagaccgggaguccagcgggaaguacacauuugcagcccacauggaugggaca uacaaguucugcuuuagcaauaggauguccacuaugacuccaaagauaguaauguucacc auugacauuggggaggcucccaaaggacaagacauggagacagaagcucaucagaacaag cuagaagaaaugauuaaugagcuggcaguggcaaugacagccguaaagcacgaacaggag uacauggaaguccgggagagaauacacagagccaucaaugacaacacaaacagcagagug guccuuugguccuucuucgaagcucuuguucuaguugccaugacauugggacagaucuac uaccugaagagauuuuuugaaguccggaggguuguuuaaaaggccuuuuccuguugaucc 201 AB025218 caaauucaugauuuacu 202 U84411 Sequence below. gcauuggcucugggcugcggccggcucggcgacgcuccucgggcagcucacugcauggucgucuggugcccccgccgccugc auccccgccgccgccccgcgacgcccaccgccgccugcccugccgccgccgccugcgccgccucgggaccggcuguaugauua 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aagcaacuuuuguaucuggagaaguaccguccgaaaaugcggcuccgcuucaaggauuccaauggucauagaaacaacuguu guauucaauaaaacuggggugccugaugccauugccuuggaaguggaacuucagaugggaccugauuugucaugcauauua cccaaugugucggcuuacugaauaagucuacugcagcuccacaggaauacugaaaaaccagucuuaccaggccacaaguuuga cagaauugcaaccucuauauuugggcuaugaucaacauguuuggacacuuagcaaaagauuuuugcuguucagcauuuaaaa ugugcuuauuauuuguaccaauugaccuuuccuaaaauaagguauugaguuaugucauuaaauguacuccugugccagaau 20 auuauuagucuauaaggaauuuagaaggauuaggugccaaaauacccagcacaauacuuguauauuuuuagcaucauacaga - 151 accaaaauugcaggaacugagaacucucagaccauccaugguguauuccuucagucauuucaaacacugcagggcuccucucg uuaucugccugcucacucuguuuacaucucccacacuuaugccagaauacgucagguuugcuuagccauccuuuauuuuuu uuauuuuuuuuuuuaacuaagucuugcgcugauuauuuaauaugucugucucauuuuguuuuguuuugggaaaccucugu cugaaaaaucaacuuuguuacagaagcacauaucuucaacaaugucuccagacaaaaagccuuauaguuaauuuaauguuug 5 cacucagaagugcaaccuaacagggagggccugaaaaagaaacgagaggaggcuauuaaauauuuuuaguaauauguugccu uugucaugugcagaacauguagaguaugcucuuaauuuaguaaauauuuuuaagacauagagauacauguguagcuaaccca uucuuauucaaaauucuggaauuuuguguuuuccnauaccuaucaggaaguuuccagcuuguuugaauuauggcuuuccuc uucccaaucucuugcaaaaaagacaaagugggaugaaucugcuagugaacugagcagaaauguuuuauaacgccuuuugagc uauguaacuuaauaauuggauacuugaucauuuguuuuauuauguaaucggauaaaauggugauguguauuaaaguuagu 10 ucaaccauauauuuauacugucugggaaugugugguuauaguucugugggagaaauaguuugucaguguucaccagcuugu aaaaacuuaguaugagagcuucaacauuuaaauaaaugaugaaccgcauucgucacugaggacacuuuugccuaaaauuaac uuaauuuguagaaaacaauggauucaguuaauaucauuucaauuuauggaaaaaauuguuaggguugccaagugcuuuuua uuaaaaguuucucuuuaaaggucuagauaauugugaaucaguugaauguugggcaccgaggggaaacaguuuguaauagau gaucuagauuuuucaguucaguuccaucagucacuuguagcucugcaauuuccagaccaguuuucucauuuuuaaguucau 15 uacaugccuguauauauuuugaaauuaacuugaaccugaguauuuggcacaugauggcuuaauaaauuuuaacuuuc 203 M62362 Sequence below. acgcuccccaaccuccaccuccccucgcucggccucuauaugcucccgggcucccuaguguuggcuggaagugggugacuua gaggcuuaaaggaggggcgccuaaccacggaccacgugugugcgggggcgacagcgccgccgggguggggcugagcgcugca agccggguucgccuugcagcgcaggagucagugggcguugcgccacgaucucucuccacuagcacuaugcucccgccccacu caccgccuuggaaagucacaggagaaggcgggcucuaagacccagcaggcaccauccuacuggcgccuucgauccgagacccg 20 uuuggacaccagggggcgaugccgacccucuauaaaagcgguccccgcgcgggccuggccauucgcgacccgaagcugcgcgg gcgcgagccaguuggggcacugggugggcggcggcgacagcggcgccacgcgcaggcuggaggccgccgaggcucgccaugc cgggagaacucuaacucccccauggagucggccgacuucuacgagguggagccgcggcccccgaugagcagucaccuccagag ccccccgcacgcgcccagcaacgcccgccuuuggcuuuccccggggcgcgggccccgcgccgcccccagccccaccugccgccc cggagccgcugggcggaucugcgagcacgagacgucuauagacaucagcgccuacaucgacccggccgccuucaacgacgagu 25 uccuggccgaccucuuccagcacagccgacagcaggagaaggccaaggcggcggcgggccccgcggguggcggcggugacuu ugacuacccgggagccccggcgggccccggcggcgcggucauguccgcgggggcgcacgggcccccucccggcuacggcugu gcggcggccggcuaccuggacggcaggcuggagccccuguacgagcgcgucggggcgcccgcgcuacggccgcuggugauca aacaagagccccgcgaggaggacgaggcgaagcagcuggcgcuggccggccucuuccccuaccagccaccgccgccaccgcac cgccgcacccgcacgcgucucccgcgcaccuggccgccccccacuugcaguuccagaucgcgcacugcggccagaccaccaugc 30 accuacagccuggccaccccacaccgccgcccacgcccgugcccagcccgcacgcugcgcccgccuugggugcugcgggccug ccuggccccgggagcgcgcucaagggcuuggccggugcgcaccccgaccuccgcacgggaggcggcggcgguggcagcggug ccggugcgggcaaagccaagaagucgguggacaagaacagcaacgaguaccggguacggcgggaacgcaacaacaucgggug cgcaagagccgagauaaagccaaacaacgcaacguggagacgcaacagaaggugcuggaguugaccagugacaaugaccgccu gcgcaagcggguggaacagcugagccgugaacuggacacgcugcggggcaucuuccgccagcugccugagagcuccuugguc 35 aaggccauggcaacugcgcgugaggcgcgcggcugcgggaccgccuugggccggcccccuggcuggagacccagaggauggu uucgggucgcuggaucucuaggcugcccgggccgcgcaagccaggacuaggagauuccgguguggccugaaagccuggccug cuccgcguguccccucccuuccucugagccggacucggugcgucuaagaugagggagucaggccguggugguuucuccuug agaccgagagacuuuuccgcggagcugagcugggggcccggcaguacuaguauuaaggaaguaaccuugugccuuggauacu caaaacucgcuccuuuuccuaccgaguagggggagcaaaaaugugccuugauauuuuauuuggaggauuccugcuuccucuc 40 gggccucagcuggcccccgugagaaaaaugaagggugcaggcccagggcaggaggaagauacaggaagcugagaucccggcag ugcccugagcugccccucagucccugucuuuagaggggagggacuuagguguuggggauuugagucuguguccucaccccc agcuacagggagguggagggcuccuaaucccuugcuuuuugcaccuccaccuacauccccccccccccacucagcuuacaaca ggccagguuuccugggugaguucauggagaaugggggcaccacccccagucagacagaaagcugaguugugaguuagccaug - 152ugguaggagacagagaccuagguuucugggcuuuguggggugggggauaggaggacacggggaccauuagccuugugugua cuguaugucgccagccgcuguugcugaaggaacuugaagcacaaucgauccaucccagagggacuggaguuaugacaagcuu cccaaauauuuugcuuuaucauccgauaucaacacuuguaucuggucucugugucccagcggugccuugugcaauggcagu gugcacgucuaugcuaaaccaccauuuuauuuggucuuuuguuuuguuuugguuuugcucugauucuugccaaacugaga 5 cucuucacuaacggcugggggaaggagcugagugaggcucucauucuuuuugguuuagggauguuuggguuuuuucgucu gccucccagaggaccaaugaaaugaagugggcuucccccucuccccuaguuguccaaggguguauguaguagugggucuuag cuuccuccggcuaagacuuaggcuuccccacccacccaaccccauccccaacggcccuggcucugggucuggaaagaaggcca ccuccagccaguucauacacacaccccuguggcugggagcagggcuggaccgcuuccuucucuucuuuuuuuggggggggg gacacaaaguuucaugcuagaugucguauguauuauaucuauaauauaaacauaucaaacucaa gaagcucagugucgugaaauggaaaccaaaccuuggagccaucgcugaguauaaaaaaaa ggaagauuuauauucngcaaagaguagccgaacuggacaaaauuacuucugaaagagaua auuuuagacaagcauaugaagaucuucgaaaacaaaggcugaaugaauuuauggcugguu uuuacguaauaacaaauaaacuaaaagaaaacuaccagaugcucacauugggaggagaug cugaacuggagcuuguggacaguuuagauccuuuuucugaaggaaucauguucaguguuc ggccaccuaagaaaaguuggaagaagaucuuuaaccucucaggaggcgagaaaacccuua 204 AA032310 guuccuggccuuaguguuug 205 M94087 Sequence below. 10 gccgguuugaguugugcgcucgggugucccuuuccucuuccccucccgcagggcuugcggccaccauggcguauuagaggc agcagugccugcggcagcguuggccuuugcagcggcggcagcagcaccaggcucugcagcggcaacccccaccggccuaagcc auggcgcucuucacgaaauccagcagcaguguugcuguaacggacaaagauaccuucgaguuaagcacauuccuggaaucca gcaaagccccacaacaugaccgagaugagcuuccugaacagcgaaguguuggcgggggacuugaugucccccuucgaccaguc ggguuugggggcugaagaaagccuaggucucuuagaugacuaucuggagguggccaagcacuugaaaccucauggguucucc 15 agcgacaaggcgggcuccucggaauggccggcuauggaugauggcuuggccagugccucagacaccggcaaggaggaugccu uuuccgggacagauuggauguuggagaaaauggaucugaaagaguuugacuucgaugcucuguuucgaauggaugaccugg aaaccaugccagaugagcucuugaccacguuggaugacacaugugaucuuuuugccccucuaguccaagagacuaauaagga gcccccucagacagugaacccaauuggccaucucccagaaaguuuaauaaaagucgaccagguugcccccuuuacauucuugc agccuuuccccuguuccccagggguucugucuuccacuccagagcauuccuuuaguuuagagcuaggcagugaaguugaua 20 ucucugaaggagacaggaagccugacucugcugcuuacauuacucuaaucccuccauguguaaaggaggaagacacucccuc ugacaaugacaguggcaucuguaugagcccggaguccuaccugggcucuccccagcauagccccuccaccuccagggccccac cagacaaucugccuucuccaggugguucccgugggucuccucggcccaaaccuuaugacccaccuggaguuaguuugacagc uaaagugaagacugagaaauuggauaagaagcugaaaaagauggagcaaaacaagacagcagccacuagguaccgccagaaga agcgggcugagcaggaggcccucacuggcgaguguaaggagcuagaaaaaaagaaugaggcucugaaagagaaggcagauuc 25 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below. ccucugcggcgcgguccucggagcggcgcgguucucggagccacgcgucugucuuccuccguggucauggcggacuaccuga uuagcggaggcaccucuuacgugccggacgacgggcucacagcgcagcagcucuucaacugcggggacggccucaccuacaau gauuuucucauucuuccuggguauaucgacuucacugcagaucagguggacuugacgucugcucuaacuaagaagauuacac uaaagaccccauugguuuccucacccauggacacugucacagaggcuggaauggccaucgcgauggcgcuuacaggagguau 5 ugguuucauccaccacaacugcacaccugaauuccaggccaaugaaguucggaaagugaagaaauacgaacagggauucauca cugaccccgugguccuuagccccaaggaucguguacgcgauguuuuugaggccaaagccaggcauggcuucugugguauccc caucacagauacaggccggauggggagucgauuggugggcaucaucuccucaagggacauugauuuccucaaggaggaagag caugaccgguucuuggaagagaucaugacuaagagggaagauuugguggucgccccugccggcgucacucugaaagaggcaa augagauucugcagcgaaguaaaaagggaaaguugcccauugugaaugaaaaugaugagcugguagccaucauugcccggac 10 agaccuaaagaagaaucgugauuacccccuggccuccaaagaugccaagaagcaacugcuguguggggcagccauuggcacuc augaggaugacaaguauaggcuggacuuacuggcccuugcugguguggauguagugguuuuggacucuucccagggaaacu ccaucuuccaaaucaauaugaucaaauacaucaaggagaaguaucccagucuacaggucauuggaggcaauguagucacugcu gcgcaagccaagaaccucauagaugcagguguagaugcuuugcgagucggcaugggaagugguuccaucugcaucacccagg aaguguuggccugugggcggccccaagccacagcaguguacaaggucucugaguaugcccgucgcuuugguguuccuguua 15 uugcugauggaggaauccaaaaugugggucauauugccaaagcuuuggcucuuggggcuuccacagucaugaugggcuccc uccuggcugccaccacugaggccccuggcgaguacuucuucucagaugggauccggcugaagaaauaccgagguauggguuc ucuugaugccauggacaaacaucucagcagccagaaccgauacuucagugaagcugacaaaaucaaaguggcccaaggaguuu caggggcagugcaggacaaggggucuauccacaaguucguuccuuaccugauugcuggcauccagcauuccugucaagacau uggugccaagaguuuaacccaagucagagccaugacguacucgggggagcuuaaauuugagaagaggacauccucugcucag 20 guggaagguggcguccacagccuccauucguacgagaaacggcuuuucugaaaacagauccaguauaugccuugaauuuuuc aauaaaaguuugggaaaaaaaaagugaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa gugugggugcagagcuggggucagggaaagcuggagccuuuugcagacccugagcugcuc acggcugagagcuggggucauuacccucaccuucauuuccuguaccuguccuucccagag ccuccuccauccacugucuccaacauggcgaacguagcuguucugguuguccuuggagcu uggccaucauugcagcugugguggcuuuugugaugaagagaaggagacacacagguagga 209 X16202 aagggcagagucugaguuuuu acaggaggggaaggccaaagcaagaaugaaagucccccgccccguaucaccacgggcacu cggggucacccucaggaacaugcagucucugcacgugaggaaagaaacacgcagagaugg 210 A1661431 acgagcacuuuuacacccuaauaaaauuagaugcacuaaccacagaccccccu - 154uuuuuuuuuuuuuuuuuaaaaaaaaaaauggcaucuuuuauucaucaaucccuguuacac acugaaauacaugcaucuuucuuauguuacuuagcaacguccuuucuauccuuucaccca uaaaucagucugaugaauucaucuuuaaauucaagaaguuuuucuuuuugaaacgcuacu uacauuuuauugucucaauaucaaagccaaucuagagauuuauucuuccuacaggugaaa uagauguuaauacgggaacagucaguacauguucaagaugacaucaaaguuaugcccuaa gcagauauuucaaggcaauaucaugccacuagcucugagacucuaaguaucacugauagu acuaaaagguagaagucagcuucaaaaacacacucuugcaauggacacugcucaugaugu cuaagauuguucacucccacagucaugauuucagaugcacaguuuuuuuugcuuuccuga 211 A1839109 gcauucgguuugac uuuuuuuuuuuuuuuuuaagagugucaccaaagcuuuauuuacaugcgucaucaucucuu uuacaaacuagauuaugguuuuaaauggaauacacaggcaauaucuacaaacgccacggg aaguacgcaccuccauuccaccgggaaggggcagauucccaaaucaaacugguuuugauc cuugagaagaaaggcggcagagcuaacucacggcagcguaugguuagacaagguccucag uacccagaaugcagcaggauugcgucugccucaaaccagacgaccaacugcugcaggugu uuaaacauggccacgcgccacacgaaauucuaguuugugugggguagaagcaagaaaaaa 212 A1849135 aaaaaaccauggcgccucgugccg gguccggauaguaaacugcucccuuacaucuccuuaaauauaaaguaaggaaaaagaaaa aacucaguucggguaaccaaguucaacaaguaauccuuggggccgcugugguaucgccaa aaucuacauaguaucucuuauuaaaauguuuugacgaaaauguaacaauuacgguacuua augguaacaauguggcugaggaagcaauaguuaacaaagaggagcuaagcuaugcaacaa accagauuucuauuggucacaaauuugaaguugagaccuguuauccaauuaccaaguacu uccgcauacaucaucauaggcauuugaagauuucaaccaaucaggagcauguuccuucua uaaaggaacccagaaccuaaccucugcauuuccuauuucuuuguagaaauggcucguacg aagcagaccgcucgcaaguccacuggcggcaaggccccgcgcaagcagcuggccaccaag gccgcccgcaagagcgccccggccaccggcggcgugaagaaaccucaccgcuaccguccc ggcaccguggcgcugcgcgagauccggcgcuaccagaagucgaccgagcugcugauccgc aagcugccguuccagcgccuggugcgcgagaucgcgcaggacuucaagaccgaccugcgc uuccagagcucggccgucauggcucugcaggaggcgagcgaggccuaccuugugggucug uuugaggacaccaaccugugcgccauccacgccaagcgugucaccaucaugcccaaggac auccagcuggcccgccguauccgcggcgagcgggcuuaauaggcacgcuuucuacacugg cacguaaaccaaaacggcucuuuuaagagccaccuccauuauccaccaaagaugcuugaa guacaaguugugagaguuuucuaggguuuccuauuauagccuuucuugacaaugugagca 213 M32459 ccacccgacgaagcagucugag uuuuuuuuuuuuuuuuuggacuucugcggcuuuuauuuuugcauguaaaccacugggggg agggggaucuugauggugggcacccuagagauuacacuggaguuccgagggcuccagaca cuagcugggaagucaggugacagaaacaaugauucagaccaaucacaugauugcaaaacu gggucuccagcagggauucugguggucagguguggaugccuaaggaagcagugacauggg aggggcacgcacugggcuggccuugagcugcugggaugacaucagggauagaggaccuag cagcugguggcuccagggaucuccgguccaugcuuuauuuggccaggggguuccugaagg accugccagcaaacuuggcuuugcugcccagcucuuccucaauucugaggaucugauugu 214 A1841389 acuu 215 X03039 Sequence below. auucuaaggaucaugucugcgagucaggauucucgauccagagacaauggccccgacgggauggagccggaaggcgucaucg agaguaacuggaacgagauuguggauagcuuugaugacaugaaucucucagagucccuccuccgugguauuuaugccuaug guuuugagaagcccucugccauccagcagcgagcuauucuuccuuguaucaaggguuaugaugugauugcucaagcccaguc - 155 ugggacugggaaaacagcuacauuugccauaucaauucugcagcagauugaauuagaucuaaaggccacucaggcuuugguu cuggcacccacacgugaauuggcucagcagauacaaaaggugguuauggcauuaggagacuacaugggugccucuugucaug ccugcauugggggcaccaaugugcgugcugaggugcagaagcugcagauggaagcuccccauaucaucguggguaccccugg ccggguguuugacaugcuuaaccggagauaccugucccccaaauacaucaagauguucguacuggaugaagcagaugaaaug 5 uuaagccgaggguucaaggaucagaucuaugacauauuccagaagcucaacagcaacacacagguaguuuuguugucugcua caaugccuucugauguccuugaggugaccaagaaauuuaugagagacccuauucggauucuugucaagaaggaagaauugac ccuggaggguauccgccaauucuacaucaauguggaacgagaggaguggaagcuugacacauugugugacuuguaugagacg cugaccaucacccaggcagucaucuuuaucaacaccagaaggaagguggacuggcucaccgagaagaugcaugcccgagauuu cacuguuucugccaugcacggagauauggaccaaaaggaacgagaugugaucaugagggaguuccggucuggcucuagcaga 10 guauuaauuaccacugaccuguuggccagaggcauugaugugcagcaggucuccuuagucaucaacuaugaccuucccacca acagggaaaacuacauccacagaaucggucgagguggucgguuuggucguaaggguguggcuauuaacauggugaccgaaga agacaagaggacucuucgagacauugagacuuucuacaacaccuccauugaagagaugccccucaacguugcugaccucauuu gaggggcuguccugcgaccuggcccuagcccaggguucaguccugggguggggcuaaggaagagcuggaggggggagggga gggagccaagggauggacaucuuguuuuuguuuuggcuuuuuuuuuuuuuuguuucaguuuuuuuucucuaugaauaaa 15 ugucacuuuuugaggc uuuuuuuuuuuuuuuuugccaggauauauuuauuacugaaaguacaagcaacugagguuu acccugggaacacccacaaugaaacguguaucuucccuguuucucagaugcugccuccuu ccacagagugaguuuucguuuaaaacucauaaugaggagaaggcagggggcuccaccccu uuccuguucaaucugaagacugaauugggcuacacugggauggagauuucaggugcugca ggucagugucaaccaaggguucgugugucaggaacucuggcugguaagaugacacaaagg cuucaugcugaagcucagggagguccagggagccuggcagaauggaaucaucauggucau caucaaacgucugugucuggaaggcuucaaggcucauaauugcaucauucucuggcaguu ccugagagagcugccccuuccuggguuugcacgcaucaaauuucacccacugguaauuga AW04979 cacaguuuugagcuucgggacaacucuuaaucagguuguggaugguuggaugagaaaacc 216 5 caaagaagucggcaccgcauga 217 D87691 Sequence below. auuguaacagaagaaggaaaggaaaagaaaguuaacauugacuuugaaccuuucaaaccaauuaauacaucauuguauuugu gcgacaauaaguuucauacagaggcucuuacagcguuacuuucagaugacagcaaguuugguuuuauuguaauagacggaag uggugcucuuuuuggcacgcuccaaggaaacaccagagaaguccugcacaaauucacuguggaucucccaaagaaacacggca gaggaggucaaucagccuugcguuuugcccguuuaagaauggaaaagagacauaacuauguucggaaaguagccgagacugc 20 ugugcagcuguuuauuucuggagaccaagugaauguggcugguuugguuuuagcuggaucagcugacuuuaaaacugaacu aagucaaucugacauguuugaccagagguugcaaucuaaaguuuuaaaauuaguugauauauccuaugguggugaaaaugg auucaaccaagcuauugaauuaucuacugaaguucucuccaacgugaaguucauucaagagaagaaauuaauaggacgauau uuugaugaaauuagccaggacacaggcaaguacuguuuuggaguugaagauacacuaaaggcuuuggaaaugggagcuguac aaauucuaauagucuaugaaaaucuggauauaaugagauacguucuucauugccaaggcacagaagaggagaaaauucucua 25 uuuaacuccagaacaagagaaggauaaaucucacuucacagacaaagagacuggacaggaacacgaacugauagaaagcaugc cucucuuggaaugguuugcuaacaacuauaaaaaauuuggagcuacacuagaaauugucacagauaagucacaagaaggauc acaguuugugaaaggauuugguggaauuggagguaucuugcgguaccgaguagauuuccagggaauggaguaccaaggagg agaugaugaauuuuuugaccuugaugacuacuagguagucgacauggguccggcaaccgugccucacccuccagcauucaac ccaaggagcauacccgugguggaguccaacagaucccugccuuacaauuggagcauuuccagaacuuaauccgugagcauug 30 gauacugaaaagaaaagugaaacaaaaccagacccaacccuacacuuugguuugucguggugucagcgcagcagccgacaacu aagucucu - 156cagaggagucauuguugcugugguggcuuuugugaugaagaggaggagaaacacagcgua agccagcugccuggaguggacuaagugacagacaaugucuucacacaucuccugugacau ccagagcccucaguuuucuuuagucaaguaucugauguucccugugagccuaugggucaa agugaagaacugugcagcccagccugcccugcacacagaacccugucccugcacugcccu ggguucccuuccacagccaaccuugcugcuccagccaaacacugggcgacaucugcaucc ugccagcuccaugcugcccugagcugcagcuccucacuuccacacugagaguaagaaucu gaaugggaccuugauucuuaacauccugaccgaggguugauuucuuguuaauuucaugga 218 AI117211 uugagaauacuuagaguuuugguuugucuugauuuuuuuucaag ugaauaaaaacgaggagccgaagauucuagggggcuacagcugcgcuuuugcagcacuga acaugguuccggguacucaagauauugcguuuguguuuggagagguguagauuguagauu ccagccgagaagaccaggaaaagauaaggauaaagaaugucauauaucucaggagcuaga ucacuucccgaugaacaaguaagaauugccucaacaaaaauggauggaauuggaccgaaa 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cugauuguggucguagccaugaccuuggaagguaagaaagagccuuggaagguaagaaag augcuuggaagugugaaguuggccuugugccugcggcccaggcuuagaagacccucgagg agggcucugaggucccuuucugugucaucauuccacuaccgcccucccaucgucccccau cccaccugccaggugccuuauuuuugugucaaagugggugcugaaggaggcaacucuguc cagaaaagacgcaguaaccaaugaccuaggauaccacccuuuggaauuggcuaaucuucc uagaaggggcggacgguaaaaacaaggaggugagaggugcaguaaaaucaaguguccaau acccucccccaugcuaaugaguuugcucgcaacccucucgcggcaggcccagcccccgcc caggcggccccggauuuguccggaacauuggagagcauaccggauaaacugaaggaguuu gggaacacuuuggaagacaaggcccgggcagccauugaacauaucaaacagaaggaaauu 221 Z22661 uugaccaagacccg 222 X99644 Sequence below. cagcgccuggggcgcggcgggcgucggcccaggagacgcguggcggcgcucggccucgcggcaucggcggcugccuggccgu uggcggcgagcgcacuugcgccugcgcagcgggguccgugccccuccuccccugggcggcccccccacccccccggcggcgug ugaauggcggccucggcggcagcgacugcagcggccucggccgcgacggccgccucggcggccucugguagcccagggucgg gcgagggcucggcgggcggugagaagcguccggcugcuuccucagccgcggcggccucugcagccgcgucguccccugcggg - 157gggcgguggcgaggcgcaggagcuucuggagcacugcggcgugugucgcgagcgccugcggcccgagcgggauccucggcug cugcccugucuacauucggccugcagugccugccugggccccgcuacacccgccgcagcgaauaauucgggggauggcggcu cggcgggcgacggcgcuaugguggauuguccagugugcaaacagcagugcuacuccaaagacaucguggagaauuauuuuau gcgugauaguggcaguaaggccucuucugauucccaggaugcuaaccagugcugcacuagcugugaagauaaugccccagcc 5 acuagcuauuguguggagugcucugaaccacuuugugagaccuguguggaggcucaccagcgggugaaauacaccaaggacc acacugugcgcuccacaggaccugcuaagacucgagauggagagcgaacagucuacuguaaugugcacaagcaugagccccuc gugcuguucugugagagcugugacacacucaccugccgcgacugccagcucaacgcucacaaggaccaucaguaccaguuuu uggaagaugcagugaggaaccaacguaaacucuuggcuucacuggugaaacgucuuggggacaaacaugccacacuucagaaa aacaccaaggagguucgaagcucgauccgccaggugucugaugugcagaagcgagugcagguugaugucaagauggccauuc 10 ugcagaucaugaaggagcugaauaagcggggucgaguucuggucaaugaugcccagaaggugaccgagggucagcaggaacg ucuggagcgccagcacuggaccaugaccaaaauucagaagcaccaggaacacauuuugcguuuugccucuugggcucuggag agugauaacaauacagcucucuugcucucuaagaagcugaucuauuuccagcugcaucgggcccucaaaaugauuguggauc cuguggagccucauggugagaugaaguuucagugggaucucaaugccuggaccaagagugcugaagccuuuggcaagauug uggcugagcguccugguacgaacuccacagguccugggcccauggcuccuccaagagccccaggcccucuaagcaagcaaggu 15 ucuggcaguagccagcccauggaaguacaagagggauauggcuuugggucagaugaucccuauucaagugcagagccgcaug uaucaggcaugaagcggucccgcucuggugagggagagguaaguggccucuuaaggaaggugccacgugugagccuugaacg ccuggaucuggaccucaccucugacagccagccaccagucuucaaggucuuuccuggaagcacuacugaggacuacaaucuga uuguuauugagcguggugcugcugcagcagcugcuggucaggcugggacugugccaccaggagccccuggugccccaccccu uccuggcauggccauugucaaggaagaagagacagaagcugcuauuggagcucccccggcugcccccgaggguccugaaacca 20 agccuguguugaugccucugacugaagguccuggugccgagggaccucgucuagcuucaccuaguggcaguaccagcucagg cuuggaggugguggcuccugagguuacuucagccccaguaagugggccagguauccuggaugacagugccacuaucugccga gucugccagaaaccaggugaccuggucauguguaaccagugcgaauuuugcuuccaccuggauugccaccucccugcccugc aggauguuccaggggaggaauggaguugcucacucugccacgugcucccugaccuaaaggaggaagauggaagccucagccu ggauggagcagauagcacuggugugguagcuaaacucucaccagccaaccagcggaaaugugagcguguucuccuggcccug 25 uucugccaugaaccaugccgucccuugcaucagcuggcuaccgacucuacauucuccauggagcagccuggugguacccuag accugaccuugauucgugcucgccuccaagagaagcugucaccuccuuauagcuccccccaggaguuugcucaagauguggg ccgcauguucaaacaguucaacaagcugacugaggacaaggcagauguucaguccaucaucggcuugcagcgcuucuuugag acacgcaugaaugaugccuuuggugacaccaaguuuucugcugugcugguagaaccaccaccauugaaccuucccagugcug gccuaaguucucaggagcucucuggcccuggugauggccccugaagcuggggcucuuguggucagcccaguccagcucuggu 30 cucuguauuuucaccccauacccuguccuuugguggccugacuccuguucuugcuggccccaucguccccucagucccucuu cacaaaaugguuuuuacuucuguggauuuaauaaaaacuucacugagucaguuaaaaaaaaaaaa uuuuuuuuuuuuuuuuuaaaaauaauuucauuuuuuaauauucuguacaaaauuucucaa ccuaugaaaauaaaguuugcaaaagucaaaguaguacaugggccugcccuggagccaggc ccagccggaucuacacuauguacaggucucccagggugagccucagcuagggaaaagcca cuaaggugccuacagagcaagagggugccaucgggccagugcagccucugcaauuuccag aucugccacuagaggucggcaugguccugauugcuugucaggcucacccucuggaagacc acagccaaugacaaagguccucaagggaaagcuuuggggucuagcuggaagugacggugg 223 A1843895 guccgccgcccaggcgcaggagcaucugcuggcaguccagcaguaaccggugaucgccaa - 158uccgucguaaccuguugaguaacuauggaagacuauaucaaaauagagaaaauuggagaa gguacuuacggugugguguauaaggguagacacagagucacuggccagauaguggccaug aagaagaucagacuugaaagcgaggaagaaggagugcccaguacugcaauucgggaaauc ucucuauuaaaagaacuucgacauccaaauauagucagccugcaggaugugcucaugcag gacuccaggcuguaucucaucuuugaguuccuguccauggaccucaagaaguaccuggac uccaucccuccugggcaguucauggauucuucacucguuaagaguuacuuacaccaaauc cuccagggaauuguguuuugccacucccggcgaguucuucacagagacuugaaaccucaa aaucuauugauugaugacaaaggaacaaucaaacuggcugauuucggccuugccagagcg uuuggaauaccgauacgaguguacacacacgagguagugacgcugugguaccgaucucca gaaguguugcugggcucggcucguuacuccacuccgguugacaucuggaguauagggacc auauuugcagaacuggccaccaagaagccgcuuuuccacggcgacucagagauugaccag cucuucaggaucuucagagcucugggcacuccuaacaacgaaguguggccagaagucgag ucccugcaggacuacaagaacaccuuucccaaguggaagccggggagccucgcaucccac gucaagaaccuggacgagaacggcuuggauuugcucucaaaaaugcuagucuaugauccu gccaaacgaaucucuggcaaaauggcccugaagcacccguacuuugaugacuuggacaau cagauuaagaagauguagcccucuggauggaugucccugucugcuggucguaggggaaga 224 M38724 ucg uuuuuuuuuuuuuuuuuacuaggcaaagaauuuuauuaacccuuuccaaacuuuauuccc aggcuucuucagcuuuauuugccgcaaagaaugaauuagguauagcgaaaacugaaaaga gcugcaguguccgggggcuugggcuuaaaaauauuagagaucuagauuuuaucagaucca uaauaaacaaaaaaauuuuaaaaagcagucaugauauaaaauagcagcuccuguaauuuc ugcaaguaucaccuucuucagaaguugcuucaauucaguuugccucauucuuagaagccu caucaaaauucuccaccagaucuggaacuucaucaucaucauccucuccaguagcaaggg AW12298 gugcuuuuccauccacagauuguuugggcagagcuucagccagucuccuuaaacuaguca 225 9 ggcugucugcaccaagcugguugaggaugcugggaagcauuucugucagcugcuuuguc uuuuuuuuuuuuuuuuuauucaugcuugccuagggauggggaauagaucauucaauaaaa acauacaguaaaaacaggggguggggagggggaaggcuuaucauguacaauguuuaaacu acaauagugauguaccuuaauuacuuccaugcacacaagucuaacauuacaaguuuuuaa aaaauaaacaccauuaagacuucuaggagcauuuuauaauaaauuccuaauuuuuucuuu guagauagaucaagcaccuccaaaauacagauuccuauacacagugagcacuuuacuuaa cguacauggacagccucaggacgagcugacgucucggaucagcucggcaggcaacaaacc auagugccaaauggaaagaagggcaguugcaaauaaacuuaaaacuaaguuaacuuuuau aauuaaauacagaaaauauacugauuugcuaaaaauaaauaagaugugauguauuuaaca 226 A1844810 cuucacuauaaagaaugaacaccaugacauccucgugccg agaagaaggaggagugggaccgcaagcaugaggaugcuaguagggaguaugagaaaggca ugaaagaguaugaaggaggaagaggggacucaucuaaaagggacaagucuaagaagaaaa agaaaguaaaagcaaagauggaaaaaaaguccacuccuucccggggcucgucauccaagu cuucauccaggcaguugagugacagcuucaagagcaaagaguuuguguccagugaugaga gcucuucaggcgagaacaagagcaaaaagaagaggaggcggacgaggacucugaagagga gcuagccaguaccccuccaagcucagaggacucugccucgggaucugaugaauaaaggag ggaauucccaccccgucacagcuccagucucucacauaguccuuggauucugugccaucu 227 AA940430 gaguaacugcucuugguggcuuccacugcccugaggcuuugagggaag 228 M38381 Sequence below. aucgucguaaucguuugcagacuucucgccgucgccuuguaagcuuugucuucgccuugcaagcuuugucuucaggguugg aaagaugagacauucaaagagaacuuacuguccugacugggaugaaagagacugggauuauggaacauggagaagcagcagca - 159gucacaaaagaaagaagagaucacauagcagcgcccgugagcaaaagcgcugcagguacgaucacuccaaaacgacagacagcu auuaucuggaaagcagauccauaaaugagaaagcuuaucauagucgacgcuauguugaugaauacaggaaugacuacauggg cuacgagccagggcaucccuauggagaaccuggaagcagauaccagaugcauaguagcaaguccucugguaggaguggaagaa gcaguuacaaaaguaaacacaggagucgccaccacacaucgcagcaccauucacacgggaagagucaccgaaggaaaagaucga 5 ggaguguagaggaugaugaggagggucaccugaucugucagaguggagacguacuaagugcaagauaugaaauuguugaua cuuuaggugaaggugcuuucggaaaagugguggaaugcaucgaucauaaagugggagguagacguguagcaguaaaaauag uuaaaaauguggauagauacugugaagcugcucaaucggaaauacaaguuuuggaacacuugaauacaacagacccccauag uacuuuccguuguguccagauguuggagugguuugagcaucgaggucacauuugcauuguguuugaacuucuggggcuua guacuuaugauuucauuaaggaaaacaguuuucugccguuucgaauggaucauaucaggaagauggcauaucaaauaugcaa 10 aucuguaaacuuuuugcauaguaauaaauugacucauacagacuugaagccugaaaacaucuuauuugugaagucugacuac acagaggcuuauaaucccaaaaugaaacgugaugaacguacuauaguaaauccagauauuaaagugguggacuuuggaagug caacauaugaugaugaacaccacagcacauugguaucuacaagacauuauagagcaccggaaguuauuuuagcccucgggug gucacagccaugugaugucuggagcauaggauguauucuuaucgaguauuaucuuggauuuacaguuuuuucgacucauga uagcagggaacauuuagcaaugauggaaaggauucuuggaccacuaccaaagcacaugauacagaaaaccaggaaacgcagau 15 auuuccaucaugaucgauuagauugggaugaacacaguucugcuggcagauauguuucucggcgcuguaaaccucugaagga guuuaugcuaucucaggaugccgaacaugagcuucucuuugaccucauugggaaaauguuggaguaugaucccgccaaaaga auuacucucaaagaagcccuaaagcauccuuucuuuuacccacuuaaaaagcauacgugauuuauaaacacagugcucugaaa ggaaucuuacagacuguaucagucuagcuuuuaauuaaguuauuuuguauagcuuaauuuguaaaacauuuuauguuuuu uagaugcuuuauuaaauacauggccaaaccaaauaacaucuuucaguaauuauagaaugauuuauuuggaauaaaauuugug 20 cuuaugaauguaaaaaaa ggacucgcgacaagcguccucagcgcgaagaggcggacucggaguccucgccuugagccu ugcaucugagaaguuccagguacuuuguacaacugcaucccagaaccuguguguuuucag caccuuuauaagugauggcugccaucaggaagaaacuggugauuguuggugauggagcuu gugguaagacaugcuugcucauagucuucagcaaggaccaguucccagaggucuaugugc ccacgguguuugaaaacuauguggcggauaucgagguggaugggaagcagguagaguugg cuuuaugggacacagcuggacaggaagauuaugacugccugaggccucucucuuauccag acaccgauguuauauugauguguuuuuccauugacagcccugauaguuuagaaaacaucc cagaaaaauggacuccagaagucaagcauuucuguccaaaugugcccaucauccugguug ggaacaagaaggaccuucggaaugacgagcacacgagacgggaguuggccaaaaugaagc aggagccgguaaaaccugaagaaggcagagauauggcaaacaggauuggcgcuuuugggu acauggaguguucagcaaagaccaaagauggagugagagagguuuuugagauggccacga gagcugcucugcaagcuagacgugggaagaaaaagucugggugccucaucuugugaagcc uugugaacgcagccucaugcgguuaauuugaagugcuguuuauuaaucuuaguguaugau 229 AF014371 uacuggccuuucauuuaucuauaauuuaccuaaga uucaagaccgaccugcgcuuccagagcucggccgucauggcucugcaggaggcgagcgag gccuaccucgugggucuguuugaggacaccaaccugugcgccauccacgccaagcguguc accaucaugcccaaggacauccagcuggcccgucgcauucguggggagagggcguaaauu aggguagugagugaauuuggaccccaaaggcucuuuucagagccacccacauuuucuaua 230 Z30939 aaaggcuguauaucgauaagcuuuuauaaaccccacucagcaacucc - 160uuaugugauaaaaaaauucaacuugguauuaacuuaacuaagggccuuggugcuggugcu uugccugauguugguaaaggugcagcagaagaaucaauugaugaaauuauggagcauaua aaagauagccauaugcucuuuaucacagcagggauggguggugguacuggaacaggugcu gcaccgguaauugcaaaagcagccagagaagcaagagcgguaguuaaagauaaaggagca aaagaaaaaaagauacugacuguuggaguuguaacuaagccguucgguuuugaaggugug cgacguaugcgcauugcagagcuuggacuugaagaguugcaaaaauacguagauacacuu auugucauucccaaucaaaauuuauuuagaauugcuaacgagaaaacuacauuugcugac gcauuucaacucgccgauaauguucugcauauuggcauaagaggaguaacugauuugaug aucaugccaggacugauuaaucuugauuuugcugauauagaaacaguaaugagugagaug gguaaggcaaugauugguacuggagaagcagaaggagaagauagggcaauuagugcugca gaggcugcgauaucuaauccauugcuugacaauguaucaaugaaaggugcgcaaggaaua uugauuaauauuacuggugguggagacaugacucuauuugaaguugauucugcagccaau agagugcgugaagaaguggaugaaaaugcaaauauaauauuuggugccacuuuugaucag gcgauggagggaagaguuagaguuucuguucuugcaacuggcauugauagcuguaacgac aauucaucuguuaaucaaaacaagaucccagcagaggaaaaaaauuuuaaauggccuuau 231 U28208 aaucaaauuccaacauuagaaacaaaagaauaugcuucaacugag ugaucaggucacauuccggugccuuccacccccuauggcacgggcgccccgccuugccau accacagcucccuccaggcuuagaccuggcuucaccgcauuucaggugcuauaccccccc cugcuuuuccccccauugcccuuaaaugccccucggccccuccauccccccggaacaggg 232 AV218217 uggcacuugccacucucaggaccaccuugccaaggagaauaaaccgaauccuguugcu [000217] Thus, the transcripts identified in this Example, the proteins they encode, and the pathways in which the proteins participate contribute significantly to HF stem cell activation. Accordingly, anagen can be induced by activation of these transcripts, proteins, and pathways. 5 EXAMPLE 9 MOLECULAR PATHWAYS ACTIVATED DURING INDUCTION OF EPIDERMAL CELLS TO DIFFERENTIATE INTO HF STEM CELLS [000218] The gene expression pattern of HF stem cells was analyzed as described in Example 8 and compared to non-bulge basal keratinocytes. 157 genes were differentially expressed in the HF stem 10 cells, as assessed by microarray analysis and quantitative polymerase chain reaction (qPCR). A group of selected genes with increased expression in HF stem cells is depicted in Table 4. A group of selected genes with decreased expression in HF stem cells is depicted in Table 5. [000219] Table 4. Genes up-regulated in HF stem cells. Numbers in parentheses are the fold increase as determined by quantitative real time PCR. - 161 - Gene Name/ Fold Sequence SEQ Protein Incr. ID name/ No. GenBk Acces #. Cell surface proteins Cd34/Cd 34 43 uuuuuuuuuuuuuuuuucacucaucacguuuauucagaagagaauacac 233 antigen (189) ccaauccucucaucucuggaaaguuuuguuccuagccaucauuaagauca ggaccccuguucuccccuuaaccccaggagaggaagcuuauagucuuugu A1847784, agauauucugaaccucugaucacaaaggguuauaaaauagugaaggggu A173145 uuggacuaggaaaggcacagacugaaaggaaucugccaggggacugaggc cacagcucccccaggagucagaggaagggggaagucacguauuuuauaga aggccaagggccucagagcaagaguauuccuuugaagagcuca Calcium-related S100a4/ 35 ugguggagcaggucucaggaaucucuucgcuucagcuucaaucauggcc 234 S1 00A4 (144) uguggucuggucgccagcaaccugaaucucaaaccuggggaaugucucaa (mts) aguucggggagagguggccucggacgccaagagcuuugugcugaaccug ggaaaagacagcaacaaccugugccuacacuucaauccucgcuucaaugc X15986 ccauggagacgccaacaccauuguguguaacaccaaggaagaugggaccu ggggaaccgaacaccgggaaccugccuuccccuuccagcccgggagcauc acagaggugugcaucaccuuugaccaggcugaccugaccaucaagcugcc agacggacaugaauucaaguuccccaaccgccucaacauggaggccauca acuacauggcggcggauggagacuucaagauuaagugcguggccuuuga gugaagccagccagccuguagcccucaauaaaggcagcugccucugcu - 162- Transcription Factors and related genes Id2 helix- 11 (25) gugguucuucggcgccagguucgcccgcuucugcccuuagguaacauuc 235 loop-helix ucuaaacugcguuucucucccaaucuuuugcaggcauuuggggacuuuu protein ucuuuucuuuuuacuuucucuuuuucuuuugcacaagaagaagucuaca agaucuuuuaagacuuuuguuaucagccauuucaccaggagaacacguu AF077861 gaauggaccuuuuuaaaaagaaagcggaaggaaaacuaaggaugaucguc uugcccaggugucuuguucuccggccuggacugugauaccguuauuuau gagagacuuucagugcccuuucuacaguuggaagguuuucuuuauauac uauucccaccauggggagcgaaaagguuaaaaaaaagaaaaaaaucacaag gaauugcccaauguaagcagacuuugccuuuucacaaagguggagcguga auuccaggaggacccaguauucgguuacuuaaaugaagucuucggucag aaauggccuuuuugacacgagccuacugaaugcuguguauauauuuaua uauaaauauauauauauugagugaaccuuguggacucuuuaauuagagu uuucuuguauaguggcagaaauaaccuauuucugcauuaaaauguaaug acguacuuaugcuaaacuuuuuauaaaaguuuaguuguaaacuuaaccc uuuuauacaaaauaaaucaaguguguuuauugaauguugauugcuugcu uuauuucagacaaccagugcuuugauuuuuuuuuaugcuauguuauaac ugaacccaaauaaauaccaguucaaauuuauguagacuguauuaagauua uaauaaaaugugucugacaucaa Id4 4(12) cgaugaaggcggugagcccggugcgccccucgggccgcaaggcgccguc 236 gggcugcggcggcggggagcuggcgcuacgcugccuggcggagcacggc AJO01972 cacagccuggguggcucggcagccgccgccgccgcugcggcggccgcgcg cugcaaggcggccgaggcggcggccgaugagccggcgcugugccugcag ugcgauaugaacgacugcuacagucgccugcggaggcucgugccuacca ucccgcccaacaagaaagucagcaaaguggagauccugcagcacguuauc gacuacauccuggaccugcagcuggcgcuggagacucacccugcuuugc ugagacagccgccaccgcccgcgccaccucuccacccggccggggcuugu ccggucgcgccgccgcggaccccacucaccgcgcucaacacugacccggu gagaagccuuggcgggcacccugggcaucgcgggaaagguggcggggcg gcgagauacggguggucuugcuccucucagggaaugacagccgcuucuc ccgucuccaccgagagccgccugcugggcuuggugauccacuggucccu gagccgagggcgguugggcuuggagcccugcgucuccggagugucccuu gcaucacaggaggcuuccccagcuucgggcucggguggggacucugcuc accugccuaguuuuccaggacgucuccugggugguggcgacacugugau augcgcacucuaaccgcuuuuccccuugguguuggguugcuguuccagg ccggcgccgugaacaagcagggugacagcauucucugccgcu - 163 - Peg3/ 12 Sequence below. 237 Paternally expressed gene 3 zinc finger protein AF038939 acuagucucgaccauguaccaucacggagacgacaccaacagugacaugaacagugacgacgacaugagccgaagugggagag aaaccccacccccucgaccaucucaugcuuuuggcagugagcgagaccuggagcgcaggggcagaagcagagauguggagcc ucgagaccgcuggccauacaccaggaaucccagaagcaggcugccucaacgggaucuuucucuuccugugaugucaagacca cauuuuggacuggacagagaugaugacagacguuccauggauuaugagucucgaucccaggaugccgagucauaccagaaug 5 uuguggaacucaaagaggacaagaagccucagaauccaauucaggacaaccuggagaacuacagaaagcugcucucgcuggg aguccagcuugccgaagaugaccgacacucucacaugacacaaggccacucaucgagguccaagagagcugccuacccaagca ccagccgaggucucaaacccaugccugaggccaaaaagccaucccacaggcgugggaucugugaggacgagucuucucaugg agugauaauggaaaaauucaucaaggauguggcucgcaaccccaaauccggaagagcaagggagcugaacgagcguccuccu ccaagguuccccaggccuaaugauaacuggaaggacaguuccuccagcagaagagagucagugauccaggagagggguuaug 10 aagggagcgcauuuaggggcggcuuccgguucaacgcagaccuggcuuccagaagcagagcucuagaaaggaagaggcguua ccacuuugauucugaugagcgggguucgggccaugagcauaaaagcugugugaggaagaagccuuuugaguguggugcuga gaugagacaggcuaugagcaugggcaaccugaacagcccuuccuucucugagucgcagucaaucgauuuuggggccaaccca uacgugugugaugagugcgggaggcaguucagugucaucucugaguuuguugagcaccagaucaugcacacuagggagaac cucuaugaauauggagaguccuuuauucauagcguggcugucaaugaggugcaaagaagucaggguggggggaaacgcuuu 15 gaguguaaggaauguggagaaaccuucaguaggagugcugcccuggcagagcaccgccaaauccaugcuagagaauaucuug cagaauguagagaucaggaggaugaggagaccaucaugccuagcccgaccuuuagugagcugcagaagauguauggcaaaga uaaguucuaugagugcaaggugugcaaggagaccuuucugcacaguuccgcccugauugagcaccagaaaauccaugguaga ggcaacucagaugacagagauaaugagcgugaacgcgaacgugaucgucuacgugcacgugcacgagagcagcgugagcgcg aacgugaacgggagcgugagcgugagcuuggggaacccuuucugaccuguccaaacuucaaugaguuucggaagauguaca 20 ggaaagacaaaaucuaugagugcaaaguguguggggagagcuuucuucaucucucaucccugagggagcaucagaaaaucca uacuagaggaaacccauuugaaaauaagagcaggaugugcgaggagaccuuugucccuagucagucucuccgacggcgccag aaaacuuacagagagaagcuguucgacuuuaacaaugccagggaugcacugaugggaaacucagacuccagcgagcaucaga aaaaccguucccgaaggaacuucuuugagggcagaggauuugagaaacccuucguugaaucucagaagagucauacuauaac aagaccaccugaaaacaaagacgaugacaagccguucacaaucagugucaacccuaaugacaagcugaaacuccccaucaugg 25 aaaauggcucccagggcaaauccugugagaggucuguuauucauagcuugggcuccgcagaagcucagaagagucauggug gacugggguucaguaaaccaagaccaguggcagagucuagcacccagagcucaagcagcauuuacuaccccagagcacacucu ggaggcaacaccuaugaaggaaaagaauacaaggacucuaucauccauagcuugccagcuccucgaccucugaaacgucauag agcaaaugaccauauucaaugugaugaggggggagaauccuccauuuauaucccagauauuauuaauaagggaaggaagauu ccugccagagaagaugcuuaugaaggaaguagcagcagcaacuaccacacaccaaauguaucccgugcugagccuccaagucu 30 uucuggagagucccaugacucuaagcaggaugucacguuuucaguucccagcucaaguguucgugaacaccagaaagcucgu gccaaaaagaaguacauugagcccaggaacaacgagaccucuguuauccacucccuaccuuuuggugaguugcuugcaggu accguagggcaaaguucuuugagugucaggaaugcggggaggccuuugcucguaggucugagcucauugagcaccagaaga uucaugauagagaaagaccuucuggaagccgacauuaugagcgcucugucauccgcagccuugcgcccagugacccucagac caguuaugcccaagaacguuucauccaagaacaagugcguaaauucagagcguuuggacaacgcucaacuaccagcaacaacc 35 ucaguguacagaaaaucuaugcccaagagacauuuaaugccgaggagccccaugauaaagaaacucauggucaaaaaauucau gacaaagagccauaugguaaggagcccaguggcaaggagccccauggugaugagccccaggacaaagaaccccuuguucagg - 164agaugcgcagugaagagccccaugaugauaagccccauggccaggagccccaugaugauaagccccauggccaggagccccau gaugauaagccccauggccaggagccccacggugaugagccccauggccaggagccccacggugaugagccccaugacaagga acccauugaucaggagaugcgcagugaagagccccacagugaagagucucauggugaugagccccauggugaagagucccau ggccaggagaaaguugaagaugcuaccauucaggccucaguuucugaagagcaucagaaagaugacgcuggugaugcaaucu 5 augaaugccaggacugugggcugggcuuuacugaucucaaugaccucacaagccaccaggacacccauagcagaaaggcucu gguugacagucgugaauaugcacauucugaaguucaugcccacuccgucagcgaauuugagaaaaaaugcucuggagagaaa cuauaugaauguccaaaauguggggagucuuucauucacagcucguuacuuuucgagcaccagagaguucacgaacaagacc agcuguauuccguaaaggccuguuaugacgcuuucaucgcucuguugcccguuagaccaaggagaaauugcacuguugaaa ggaauccugccguuucugggucagccauucgaugccgucaguguggacaaggcuucauucacaguucugcccuaaaugagc 10 acaugagacagcacagagauaaugaaauaauggaacagagugagcuuucagaugagauuuucauucaaggccuagcccucac ugaguaucaggggagugaaacagaagagaagcuuuucgagugcacaaucuguggggaaugcuucuucacugccaaacagcu ggggaccaccacaccaaaguucacaaggaugagcccuaugaguaugggcccuccuacacccaugccuccuuucucaccgagcc ccucaggaagcacaucccacuguacgaaugcaaagauugcggccaguccuuccuagacgacacugucaucgcugagcgcaug guguuucauccugagcgagaaggugggucagaaauaguagcugccacugcccaagaggucgaagccaauguccucaucccac 15 aagaaguacugcgaauccaggggucaaaugcagaagcugcugagcccgaaguggaggcugcagagcccgagguggaggcugc agagccugagguggaggcugcagagccuauuggagaggcugaagggccagauggagaagcugcugagccugauggcgaggc ugagcagcccaauggagaggcugaacagccaaacggugaugcugacgagccagacggagccgggaucgaagacccagaagaga gagcugacgagccugaggaagacgucgaagagccagagggagaugcagaugagcccgauggugcagacauugaagacccaga agaggaaggagaagaucaagagauugagguugaagaaccauacuacaacugucaugaaugcgcagaaacguucgcuuccagc 20 ucagccuuuggcgagcaucugaaaagucacgccagugugaucaucuucgagccggccaaugcuccuggagagugcucuggc uacauugaacgggccagcaccagugcagguggugcggagcaggcagacgacaaguacuucaaaugugaugugugcgggcaac ucuucaacgaccgccucucccuugccagacaccagaauucucacacugguugaguaaccaggcugaagaaaagaagagcaaag ccaaaccuucuucccagaaccagacccuuaauaaaucacaaagagagccuaaaccaacccauaaugucuauaagaaauucaccu uccuguauacauaccggacuucacaucaaagacuuucacucucaucacagacugaaaaaagaaaagacauugaacgcaggga 25 ucuuucaguuuuagcuguucccuauggaacaucaguguauauuugggaaagcuagagugaacaucuacaucuuccauuuca ucuaaguaacuagauugagggaaaccuagugacaauuccagaccacagagguugccccagucgacuguaaaugauaccccuu ucauacccuauacauaaugauuccugccauguauauaaaugagcaaaucagugauacauauauuuggauuuagugugcuau agaauuuacaguuuacucuacagagcuaccuagccugguacucugauuuuuucccugaggaggaagagagcaacaauuuagc auauauuuguaaguauuguccaugcagaagcuuuucugugcaucauuugaaccccauuaguauccuuuccaguaauggagu 30 guucuguccccuaccucuuagauaguccugugaaggugugggugugaaagaucgugugucuuugaauccuggcugugugg aaacaggcauuuuagcuucuacagccauuuggugugcacccagaccccuugagacugauuguguaacccuuuacaauauaug gauuugucucugugacccaaaucaacccaucccuacauuuauauaccuuacagugguuuucuugc Growth Factors, Receptors and Related genes Fz2/ 9 (17) uuuuuuuuuuuuuuuuuaccguucuuuauuuaaaaaaauaaaauagga 238 Frizzled 2 guccguagggugcacccuccccccuccugagugaaggagggcacggugc aguccggaccugggagaggggaaagcccggcaggcaggcgagaccgcuuc AW123618 acacaguggucucgccaugccggcuguuggugagacgaguguagaacuu ccuccacgagugcagugucuugccggaccagauccagaagcccgacguga ugcccacgaugagcgucaugagguauuugaucauguagacugugaaguc gggcgacaugcggggcguguagugggccgggcaggggauggcuaggcuc uugcagugcuggcuuacccaggagcgcucccagugcucgcggaaggccu gcucauagaaguagcaggcgaug - 165 - Dkk3/ 6 (22) Sequence below. 239 Dickkopf 3 AJ243964 ggccgcgucgacgccucuccagcugcucuguggcagcccagcuaccggucgugaccagauccagcuugcagcucagcuuugu ucauucgaauugggcggcggccagcgcggaacaaacaugcagcggcucggggguauuuugcuguguacacugcuggcggcg gcgguccccacugcuccugcuccuuccccgacggucacuuggacuccggcggagccgggcccagcucucaacuacccucagg aggaagcuacgcucaaugagauguuucgagagguggaggagcugauggaagacacucagcacaaacugcgcagugccgugga 5 ggagauggaggcggaagaagcagcugcuaaaacguccucugaggugaaccuggcaagcuuaccucccaacuaucacaaugag accagcacggagaccagggugggaaauaacacaguccaugugcaccaggaaguucacaagauaaccaacaaccagaguggaca gguggucuuuucugagacagucauuacaucuguaggggaugaagaaggcaagaggagccaugaauguaucauugaugaaga cugugggcccaccagguacugccaguucuccagcuucaaguacaccugccagccaugccgggaccagcagaugcuaugcacc cgagacagugagugcuguggagaccagcugugugccuggggucacugcacccaaaaggccaccaaagguggcaaugggacca 10 ucugugacaaccagagggauugccagccuggccuguguugugccuuccaaagaggccugcuguuccccgugugcacaccccu gcccguggagggagagcucugccaugaccccaccagccagcugcuggaucucaucaccugggaacuggagccugaaggagcu uuggaccgaugccccugcgccaguggccuccuaugccagccacacagccacagucugguguacaugugcaagccagccuucg ugggcagccaugaccacagugaggagagccagcugcccagggaggccccggaugaguacgaagauguuggcuucauagggga agugcgccaggagcuggaagaccuggagcggagccuagcccaggagauggcauuugaggggccugccccuguggagucacu 15 aggcggagaggaggagauuuaggcccagacccagcugagucacugguagaugugcaauagaaauggcuaauuuauuuuccc aggaguguccccaaguguggaauggccgcagcuccuucccaguagcuuuuccucuggcuugacaagguacagugcaguaca uuucuuccagccgcccugcuucucuggcuugggaaagacaggcauggcggguaagggcagcggugagucgucccugcugu ugcuagaaacgcugucuuguucuucauggauggaagauuuguuugaagggagaggaugggaaggggugaagucugcucau gauggauuugggggauacagggaggaggaugccugccuugcagacguggacuuggcaaaauguaaccuuugcuuuugucu 20 ugcgccgcucccaugggcugaggcaguggcuacacaagagcuaugcugcucuguggccucccacauauucaucccuguguu ucagcuccuaccucacugucagcacagcccuucauagccacgcccccucuugcucaccacagccuaggaggggaccagagggg acuucucucagagccccaugcucucucucucaaccccauaccagccucugugccagcgacagcccuuccaaauggagggagu gaaauccuuugguuuuauuauuuucuccuucaaggcacgccugccacuaaggucaggcugacuugcaugucccucuaacgu ucguagcagugugguggacacugucuuccaccgacugcuucaauaccucugaaagccagugcucggagugcaguucgugua 25 aauuaauuugcaggaaguauacuuggcuaauuguagggcuaggauugugaaugaaauuugcaaagucgcuuagcaacaaug gaaagccuuucucagucacaccgagaagucacaaccaagccagguuguguagaguacagcugugacauacagacagaagaag gcugggcuggaugucaggccucagaugacgguuucaggugccaggaacuauuaccauucuguaucuauccagaguuauuaa aauugaaaguugcacacauuuguauaagcaugccuuucuccugaguuuuaaauuauauguauacacaaacauguggcccuca aagaucaugcacaaaccacuacucuuugcuaauucuuggacuuuucucuuugauuuucaauaaauacaaauccccuucaugc 30 aaaaaaaaaaaaaaa Sfrpl/ 6 Sequence below. 240 Secreted frizzled related protein 1 U88566 gcacgagcagcccgcagcccgccgcgccugugcgagccgggacagcacucggccccgcgcgcuccccgccccgcgccagcccc gccgcggcgaccugcugcagcggaggaccccaucgaucggagacccggggagcagcgcgcagcccgcgagccgacgggcccc gacugcgucuuuguccccggaggcuccgggaaguuugcagcgggacgcgcgcgugaaggcagcgugggcagccccgacguc - 166gccgagcaacaugggcgucgggcgcagcgcgcggggucgcggcggggccgccucgggagugcugcuggcguuggccgccgc ucugcuggccgcggguucggccagcgaguacgacuacgugagcuuccaguccgacaucggcucguaucagagcgggcgcuu cuacaccaagcccccgcagugcguggacaucccgguggaccugaggcugugccacaacgugggcuacaagaagauggugcug cccaaccugcuggagcacgagaccauggcagaggugaagcagcaggccagcagcugggugccgcugcucaacaagaacugcca 5 caugggcacccaggucuuccucuguucgcucuucgcgcccgucugucuggaccggcccaucuacccgugucgcuggcucug cgaggccgugcgcgacucgugcgagccggucaugcaguucuucggcuucuacuggcccgagaugcucaaaugugacaaguu ccccgagggcgacgucugcaucgccaugaccccgcccaauaccacggaagccucuaagccccaagguacaaccguguguccuc caugcgacaacgaguugaagucagaggccaucauugaacaucucugugcaagcgaguuugcacugaggaugaaaaucaaaga agugaagaaggaaaacggugacaagaagauuguccccaagaagaagaaacccuugaagcuggggcccaucaagaagaaggagc 10 ugaaggcgcuugugcuguuccugaagaacggugccgacugucccugccaccagcuggacaaccucagccacaacuuucucau caugggccgcaaggugaagagccaguaccugcugacagccauucacaagugggacaagaaaaacaaggaguucaaaaacuuca ugaagagaaugaaaaaccacgagugucccaccuuccagucuguuuuuaagugauacuggggcggacuggggaaggggagug uggcuuggggugagggugggggcgcguggaugacccuggcucuunggggcucacauauugcucucacccauacaguugug gcuuuugcauugcaccuggcucuguuccuacagcgaacccucucccuunccuccauagccacauccagcuaaggccacggcc 15 uuuagauuaggaaggcuuuuuuuuuuuuaagggcugcagcagggccagcagcgacgugcaaaaggagaggcagaauccuuu cacugagccuggggcacaaaaaacagaaaauguunnccgguuuggaaaaacaaaacaaaacggauuguaaagaacugcagacg gacagcugcucagcucaacguuguucgggacaucauuaccaauugcuuguggagucuaagccucuacagguagaagagucu gaucauugccaagccaggcugcuuucaguuuauuauuaaucccccucuuucugccuuagauagaccaucgccaccuucaaaa cacacacacacacacacacacacacacacacacacacacacacacacacacacacuucugaaaguagccaggguaucccaguaua 20 gaacgggauagcuaaggguuugggugggaggccacugcuacucuaccuucagcuuuugaacuggccaccuuugauaggaaa cugaggucucagauggacacuucuaccaguccaucgggauacaaggaugccaggcaagggucugcuuuugucugaaggagg uacgugggcaugaagagacaugaggcauuucaggcugagaagcaacagcuacuaguuuucaacaauagaguggaagaaauga gcaaagguagaaaugucaagcaggucacaagucagggugauugggggaauccugugccaacagccucacuuuguaauuccau cugucacuuucaaaagaacagcagcauaagacagggauaaaagcccacauacccuccaaggcuugaguaaaaguccacacuca 25 gcauuucaaagacuaacgucguugacugcccaaggcugcccucuuaauacaccgccuaugcaugugcuguggaaggcaacuc ugugcaugugcuguggaggagaugggccucauggcugugcuggcugcccggaaucaguauagcguggaaggagacaguauc cauagacucugcuuuucugcaaggaaagcccuuuuccuuauacaugauugccuauaauucagacaaauuuaaaaucgcugcc ugccugagcccuccaccuuuacuuuugcauucuccggucauauucuuuugaggcuaaagugcccuauccgaggagaugguu ucaaaggcuaacuaaucugcagcuuucccaagugcccagagguauuucucaaaguugguaugcuuaauaagugauguaaaua 30 uuccaguucucuuaggcagccuuacuccuguugucccug Dab2/ 15 Sequence below. 241 Disabled homolog 2 U18869 aauuccgaguggccgcgcggcuauuuaaguggcguuacuccgcguccucggcgcugcagccuugaggcuucgggcgcgggg gaagucaugcuggcuccacagaagcacuagcuaguccguguacuuuguggguucuguccuuuugagaccugcccgccgggg auuggcugguaucagugacugucuacugcuggauuuucugcuugccuucccgucaugucuaacgaaguagaaacaagcaca accaauggccagccugaccaacaggcugccccgaaagcgccaucaaagaaggagaagaagaaagguucugaaaagacagacga 35 guacuuguuggccagguucaaaggugaugguguuaaauacaaggccaagcuaaucgguauugaugaugugccugaugcucg aggagacaaaaugagucaggauucuaugaugaaacucaagggaauggcagcagcuggucgcucucagggacaacacaagcaa agaaucugggucaacauuuccuugucuggcauaaaaaucauugaugagaaaacugggguaauugaacaugaacauccaguaa auaagauuuccuucauugcucgugaugugacagacaacagagcauuugguuauguguguggaggugaaggccagcaucaau uuuuugcuauaaaaacagggcaacaggcugagccauuagucgucgaucuuaaagaccuuuuucaaguuaucuauaauguaa - 167agaaaaaggaagaagauaagaaaaagguugaagaagccaacaaagcagaagagaauggaagugaggcccuaaugacccuugau gaucaagcuaacaaauugaagcuggguguugaccagauggauuuguuuggggacaugucuacaccuccugaccuaaauagu ccaacagaaagcaaagauauccuguuaguggaucuaaacucugaaaucgacaccaaucagaacucuuuaagagaaaauccauu cuuaacaaauggagucaccuccuguucucucccucgaccaaagccucaggcauccuucuugccugagaacgccuuuucugcc 5 aaucucaacuucuuucccaccccuaacccugauccuuuccgugaugaucccuuugcacagccagaccaaucggcacccucuuc guucgauucucucacaucuccagaucagaagaaagcgagucugaguagcucgucuacuccacagaguaaagggccccugaac gucgauacugauuacuuuggucagcaauuugaccagcucucuaaccggacuggcaaaccggaagcucagggaggcccguggc ccuacccaaguucgcagacccagcaagcagugagaacucaaaaugggguaucugaaagagaacagaacggcuuccauaucaaa ucuuccccgaacccuuuugugggaagcccucccaaaggacuaucgguaccgaauggcguaaagcaggacuuggaaaguucug 10 uccaguccucagcacaugacuccauagccauuaucccaccuccacaaaguaccaaaccaggaagaggcagaaggacugcuaag ucuucagcaaacgacuugccugcuucagacaucuuugccucagaaccuccaggccagaugucccccacaggacaaccugcagu cccgcagucgaacuuccuggaucucuucaaaggcaaugcuccucccccaguggggccccuuguaggucuagguacgguccca guaacacccccccaagcaggacccuggacgccuguugucuacaguccuucgacaacuguggucccaggagccauaauaagug gccagccucccaguuuucgccagccacucguuuuugguacaaccccagcaguacaagucuggaaucagucuccaucauuugc 15 aaccccagcuuccccuccaccccccacaguuugguguccuaccacaucuguggcgcccaacgcuuggucauccacaagcccuc uggggaauccuuuucagaguaauaauaucuuuccaccucccaccauguccacucaguccucuccucagccuaugauguccuc uguucuggccacaccgccucaaccaccuccccgaaauggcccacuaaaggacauucccagugacgcuuucacuggcuuagacc cccuuggggauaaagaggucaaggaagugaaagaaauguuuaaggacuuccagcugcggcagccaccucuuguucccucaag gaagggggagacgccucccucugggacuucaagcgccuucuccaguuacuucaacaauaaaguuggcauuccucaggagcau 20 guagaccaugaugauuuugaugccaaucaacuguugaacaagauuaaugaaccaccaaagccagccccgagacaaggugucc ucuuggguaccaagucugcugacaauucacucgagaacccuuucuccaaaggguucagcucaucaaaccccucugugguuuc ucagccugcaucuucugauccccacaggagcccuuucggaaauccuuuugccuagcuucugaaguuguaaugaugacuaucc agaugagcaaaagacuggcuuuggucaagaaugaagcagacagccagaaacauguugaccucuguccucgcuccagcuuuga cguauuaucuguuacccuauuuguuuuggccucuuguacuuguaaaaugccuuucauuuuccugucuaggcuaaagcuaaa 25 cuuaaacuauggcuuuacguaaauuaagcuccuaaacucucuagcuccaauauaaaugaaguagcuucccuaucaaaucccu gucuguugugcccccuugaaacuuccagaauauucuccauucuacccuccauuugggaggagcggcuaccuuuacccuuaa uaucacacugccuugagucaauguccaaauacucauagcucucaaagucauuugggguuccuggugugcggccuaaaccuaa agcauccuauuaauagggaaguaagacaccuugcuuccuauguccacucagggagaauuuuauuuaauaaaaugaaagcaag acuaacuucucaaauccacccaaggaccauuuugagauggucguuucucagcuaacugcaccauuuaccaauccugccccaag 30 uggugcuuacauuugacuugaagaagagaaagagcuaacucaaaacacaaggcauuauucaaagcuaauaaaacaauuucuc ccuggggccccacauuguuuucauuccagauacguugcagcuguuugacccugaugacauuaugcccuacauuuuccuuga agauccugauuuuauuucaugugauuuuuguuucucaauaaagaugauuauugugugcacggaauuc Cktsflbl/ 12 (12) Augaaucgcaccgcauacacugugggagcguugcuucuccuccugggga 242 Gremlin, cccuacugccaacagcugaggggaaaaagaaagguucccaaggagccauu Cysteine ccgccuccugacaaggcucagcacaaugacucugagcagacccagucccc knot accacaaccuggcuccaggacccgggggcggggccaggggcggggcaccg superfamily ccaugccuggagaggaggugcuugaguccagccaagaggcccugcacgu 1, BMP gacagagcgcaaguaucugaagcgagauuggugcaaaacucagccccuga antagonist 1 agcagaccauccacgaggagggcugcaacagccgcacuaucaucaaccgc uucuguuauggccagugcaacuccuucuacauccccaggcacauccgaaa AF045801 ggaggaaggguccuuucagucuugcuccuucugcaagcccaagaaguuc accaccaugauggucacacucaacuguccugagcuacagccacccaccaa gaagaaaagggucacacgcgugaagcagugccguugcauauccaucgacu uggauuaa - 168- Fgfrl/ 10 Sequence below. 243 Fibroblast growth factor receptor 1 U22324 guggaauauccauggagguacggagccuuguuaccaaccuuuaaccgcagaacugggauguggggcuggaagugccuccu uucugggcugugcuggucacagccacucucugcacugccaggccagccccaaccuugcccgaacaagcucagcccuggggag ucccuguggaaguggagucucuccugguccacccuggcgaccugcuacagcuucgcugucggcuucgcgaugaugugcaga gcaucaacuggcugcgggauggggugcagcugguggagagcaaccguacccgcaucacaggggaggagguggaggugcggg 5 acuccauccccgcugacucuggccucuacgcuugcgugaccagcagccccucuggcagcgauaccaccuacuucuccgucaa ugucucagaugcacucccauccucggaagaugaugacgacgacgaugacuccuccucggaggagaaagagacggacaacacca aaccaaaccguaggccuguagcucccuacuggacauccccagagaaaauggagaagaaacugcaugcggugcccgcugccaag acggugaaguucaagugcccgucgagugggacacccaaccccacucugcgcugguugaaaaauggcaaagaguuuaagccug accaccgaauuggaggcuacaagguucgcuaugccaccuggagcaucauaauggauucuguggugccuucugacaagggcaa 10 cuacaccugcaucguggagaaugaguaugggagcaucaaccacaccuaccagcuugacgucguggaacgaucuccgcaccga cccauccuucaggcagggcugccugccaacgagacaguggcccugggcagcaauguggaguucauguguaagguguacagcg auccgcagccucacauucaguggcugaagcacaucgaggugaacgggaguaagaucgggccagacaacuugccguaugucca gauccugaagacugcuggaguuaauaccaccgacaaggaaauggaggugcuucaucuacggaaugucuccuuugaggaugc gggggaguauacgugcuuggcggguaacucuaucggacucucccaucacucugcaugguugaccguucuggaagcccugga 15 agagagaccagcugugaugaccucaccgcucuaccuggagaucauuaucuacugcaccggggccuuccugaucuccugcaug uugggcucugucaucaucuauaagaugaagagcggcaccaagaagagcgacuuccauagccagauggcugugcacaagcugg ccaagagcaucccucugcgcagacagguaacagugucagcugacuccagugcauccaugaacucugggguucuccugguucg gcccucacggcucuccuccagcgggacccccaugccggcuggagucuccgaauaugagcucccugaggauccccgcugggag cugccacgagacagacuggucuuaggcaaaccacuuggcgagggcugcuucgggcaggugguguuggcugaggccaucggg 20 cuggauaaggacaaacccaaccgugugaccaaaguggccgugaagauguugaaguccgacgcaacggagaaggaccugucgg aucugaucucggagauggagaugaugaaaaugauugggaagcacaagaauaucaucaaccuucugggagcgugcacacagga ugguccucuuuaugucauuguggaguacgccuccaaaggcaaccuccgggaguaucuacaggcccggaggccuccugggcu ggaguacugcuauaaccccagccacaaccccgaggaacagcugucuuccaaagaucugguauccugugccuaucagguggcu cggggcauggaguaucuugccucuaagaaguguauacaccgagaccuggcugcuaggaacguccuggugaccgaggauaac 25 guaaugaagaucgcagacuuuggcuuagcucgagacauucaucauaucgacuacuacaagaaaaccaccaacggccggcugcc ugugaaguggauggccccugaggcguuguuugaccggaucuacacacaccagagcgauguguggucuuuuggagugcucuu gugggagaucuucacucuggguggcuccccauaccccggugugccuguggaggaacuuuucaagcugcugaaggaggguca ucgaauggacaagcccaguaacuguaccaaugagcuguacaugaugaugcgggacugcuggcaugcagugcccucucagaga ccuacguucaagcaguugguggaagaccuggaccgcauuguggccuugaccuccagccaggaguaucuggaccuguccauac 30 cgcuggaccaguacucacccagcuuucccgacacacggagcuccaccugcuccucaggggaggacucugucuucucucauga gccguuaccugaggagcccugucugccucgacaccccacccagcuugccaacaguggacucaaacggcgcuga - 169- Fgfl / 10 auggcugaaggggagaucacaaccuucgcagcccugaccgagagguucaa 244 Fibroblast ccugccucuaggaaacuacaaaaagcccaaacugcucuacugcagcaacg growth ggggccacuucuugaggauccuuccugauggcaccguggaugggacaag factor 1 ggacaggagcgaccagcacauucagcugcagcucagugcggaaagugcgg gcgaaguguauauaaaggguacggagaccggccaguacuuggccaugga M30641 caccgaagggcuuuuauacggcucgcagacaccaaaugaggaaugucugu uccuggaaaggcuggaagaaaaccauuauaacacuuacaccuccaagaag caugcggagaagaacugguuugugggccucaagaagaacgggagcugua agcgcgguccucggacucacuauggccagaaagccaucuuguuucugcc ccucccggugucuucugacuag Gpr49/ 64 Sequence below. 245 G protein- (377) coupled receptor 49 FEX AF110818 auggacaccuccugcguccacaugcuccuguccuugcuggcgcugcugcaguugguggccgccggcagcucaccgggaccag augcgauaccgcggggcugcccaucacacugucacugugagcuggauggcaggaugcugcucaggguggacugcucggacc uggggcucucggagcugcccuccaaccucagcgucuucaccuccuaccuggaccucaguaugaacaacaucagucagcuacc cgccagucuccuacaucgccucugcuuccuagaagaguuacgucuugcuggaaaugcuuugacacacauucccaagggagcg 5 uucacgggccuucacagccucaaagugcuuaugcugcagaacaaccagcugagaaagguuccggaggaagcgcuacagaauu ugagaagccuucaaucccugcgccuagaugccaaccacaucagcuacgugccacccagcuguuucagcggccugcacucccug aggcaccuguggcuagaugacaaugcucucacagacgucccuguccaggcuuucagaaguuuaucagcccugcaagccauga ccuuggcccugaacaaaauacaccacauagcagacuacgccuuuggaaaccucuccagccucgugguucugcaucuccauaau aauagaauccacucccugggaaagaaaugcuuugauggacuccacagccuggagacuuuagauuuaaauuauaauaaccuug 10 augaauuccccacugcaaucaagacacucuccaaccuuaaggaacuaggauuccacagcaacaacaucaggucaauaccggag cgagcguucguaggcaacccuucucuuaucacaauacacuucuaugacaaccccauccaauuuguuggaguaucugcuuuuc agcauuugccugaacuaagaacacugacuuugaauggugccucgcacauuacugaauuuccucacuugacaggaacugccac ccuggagagucugacuuuaacuggagcaaagaucucaucucuuccccaggccgucugugaucaguuaccuaaucuccaagug cuagauuugucuuacaaccuacucgaagacuuacccaguuugucaggcugccaaaaacuucagaaaauugaccugaggcaua 15 acgagaucuaugaaauuaagggcagcacuuuucagcaguuguuuaaccuccgaucucugaacuuagcauggaauaaaauugc uaucauucaccccaaugcguuuucuacguugccgucucuaauaaaguuggaccuaucauccaaucuccugucguccuucccu gugacuggguuacaugguuuaacucacuuaaaauuaacagggaaccgagccuuacagagccugauaccaucugcaaacuucc cagagcucaagauuauagaaaugccaucugcuuaccaguguugugcauuuggggggugugagaaugucuauaaaauuucua accaauggaauaaagacgacggcaacaguguggacgaccuucauaagaaagacgcuggguuauuucaaguucaagaugagcg 20 ggaccuugaagauuuccuacuugacuuugaggaagaccugaaugcccuucacucggugcagugcucgccuuccccagguccc uucaagcccugugagcaccuauuugguagcuggcugauccgaaucgggguguggaccacggcaguacugacgcuuuccugc aaugccuugguggcuuugaccguguucagaacuccccuguacaucucuuccauaaagcugcuaauugggguaaucgcggua guggacauucucaugggggucuccagugcugugcuggcugccguggaugcauucacuuuuggccguuuugcucagcacgg ugcguggugggaagacggaaucggcugccaaaucguuggcuuccuguccauuuuugcuuccgaaucgucgaucuuccugcu 25 cacucuggcagcgcuggaacgagguuuuucugucaagugcucuucgaaguuugaagugaaagcuccccuuuuuagccugag agcgaucguuuugcuauguguccuguuggcccugaccauugccacaauccccuugcuaggaggcaguaaguacaaugccu uccccucugccugcccuugcccuuuggggagcccagcaccacgggcuacaugguggcucucguguugcucaacucucucug - 170uuuccucauaaugaccauugccuacacaaagcucuacugcaguuuggagaaaggagagcuggagaaucuuugggauuguuc gauggugaagcacauugcucuguugcucuucgccaacugcauccuuuacugccccguggcuuucuuauccuucuccucuuu gcuaaaccucaccuuuaucaguccugacgucauuaaauuuauacuucucgugaucgucccacuuccuuccugucucaaccca cuucucuacauugucuucaauccccauuuuaaggaggauaugggcagccugggaaagcauacccguuucuggaugagauca 5 aaacacgcgagucugcuguccauuaacucggacgauguugagaaacgguccugugagucaacccaagccuuaguauccuuua cccacgccagcauagccuaugacuugccuuccacuuccggggcaucaccagcuuaccccaugacugaaagcugucaucucuc uucaguugcauuugucccaugucucuagugacuaugagagaggaacguuuuuaagaguuggaaaccugaaaagugauuucu aucagagcaguagcuaagaaaagcugagcuaaaaaccuaccuuaaaacccaagcaaacaucucuaaauugguguggaaacagu ggugccuuagagcaggagagcaucauuaaacaccgcuuguaucauuuguucagcuaagaaggaaagccaucaagucacuuag 10 gugaacccagaugagaaaagcagccugaaaugcucuucgcauuguagucucuucugacucaccagcauagucucccauagug agaagacucguuggaugacucaauggguguauuuaaauccacaaauuccuuguuuaaaagguuagaguuuuaagaaaaaaaa aaaaaaaaa Igfbp5/ 37 Sequence below. 246 insulin-like growth factor binding protein 5 L12447 uuuuuuuucuucaccuccucccuuuucaaggccuccaagcuaauuauuucuguugcuuuggagugagcaauucugugguu cucuccaccaccacccccaauucugacccgaucccgccuggggguuucuacggucuccgcucacucugcgugcaccuggcgc 15 gccucuuuuuuucacccccaaccuguugcaagucuuuaauccucgcaauugggacuugcgugcaggcaccugaauccuccu ugccucauauuuugcaaguguuugggggagagcaccugcucuaccugcaagagauuuaaaaggaaaaaaaucuccaggcucc cucuuucuccacacacucucgcucuccugccccgccccgagguaaagccagacuccgagaaaauggugaucagcgugguccu ccugcugcuggccgccuaugccguaccggcucaaggccuggguucuuucgugcauugugaacccugcgacgagaaagcucu guccauguguccccccagcccucugggcugugagcuggucaaagagcccggcuguggcugcugcaugacuugcgcccuggc 20 ggagggacagucguguggugucuacacagagcgcugcgcccaggguuugcgcugccucccccggcaggaugaggagaagcc gcugcacgcccugcugcacggccgcgggguuugccucaacgaaaagagcuacggcgagcaaaccaagauagagagagacucu cgggaacacgaggaacccaccaccuccgagauggcugaagagaccuacucccccaaggucuuccggcccaagcacacucgcau uuccgagcugaaggcugaggcugugaagaaggaccgcagaaagaagcugacccaguccaaguuuguggggggugcagagaac acugcccaccccagagucaucccugcaccugagaugagacaggaauccgaacaaggccccugccgcagacacauggaagcuuc 25 ccuccaggaguucaaagccagcccacgcauggugccccgugcuguguaccugcccaacugugaccgcaaaggauucuacaag agaaagcaguguaagcccucccguggccgcaaacguggcaucugcugguguguggacaaguacggaaugaagcugccgggca uggaguacguggauggggacuuucagugccacgccuucgacagcaguaacguugagugacgcguccccucccuuccuccccc uauccuacccccccagccccaacuccagccagcgccucccuccaccccaggacgucacucauuucaucucauuuaggggaaau auauauacauauauauuugaggaaacugaggaccucggaaucucuagcaagggcuaaggagacacuccccaccaugaccccg 30 gaaauguauuccuuuuugaagcaaguugaacggacagagaagggaaggagagaagaagcaagagggagcgagagauggaaag aaagcaaagcguuggaauagaggaaaagagggaaggacagauaggauuagagagagaagagagaaacagcaaggcagaaagga cuccacaaccaaggcugaaucugcccuuuugcuuucagcucuagccuggggucagaaaaaguguggcauucagugacaccca guuuagauuggucaaggggagaaaagaaacaaggugugucagugccucucgggucuguccccuccugcagccagcagugug gauggcuagaccccucacccuccucuccucuuacccaagugcagggugauuucauccccaaauuuacaaagacuaaaaugcau 35 uccaucccucugaaaauaaacaaaagugagugauugaagauagguuuucccccagcagacaagugaacucagaaugugugca aauuuuacucuuguuaaagauuuuuuuaagaagucaguacgcacccccaacacuggaaagacuugauucuccagggugacaa - 171 gcaauucagaagcgcguggcuucggcccuugauuucacuagacucaaagcuggcccggcagccucuguggaggaggaugag agguggagaaaaccaaggggcuuguacucacccacaagacuccauguagacuuuauaggcauauaaaucuauuuucuuuacc uuuuuuucccuuucccuuucuuucgaaguuuugcauuaccucuuuaaaguaguuuuuuuuaggacacugaagaucuuccu cauucugggaaaaauccauauuucacaaauacaacccagaacgccagcuuggccugcguccaggcagccuuucucgugagcu 5 acaaguguggcucuuuuguggggcaccgauuuggaucuucucaugauuccaaacguguguugaagugaauccaccaagcca gguaacugccagcacccaagggugcaucaagugcauagcccaggucaccccauuucagccuuccaacccgcagaaaguaacug ucucacaccacaccacauaaaccugccagauccaucuguaacccacuggccugcccagaccuuuuuuucccaucugcauuuuu uuuuuugaacugcauuuugaaagccucccucagaugccaggcugacagaucagagagaaacuaacaugagagaugacagagg aggaggaaguggagggugggggcagagacuuccacagagagacauagaagauggagcagaggucuggggguggggaggaca 10 agaaagagacagagagaggaaaauaccaauagaauuuuccuuggugucucccaucuaaucaacucucugagauuugagagga aaaagaaggcaggggaagaacuugagguagaaaugaggucaguucaagucacagggcccagaugguggguaacugaggcagg auccagacuugagacacacgguuggaaacaaggcugguuagccugacuggguauugaagggugaagaggaugccuuggaaa gacagcacaacuucaguucaacuucaggcccccaaggaggaacugaggccaaagaauccuucaagugcuucaugagucuccuc ugcccgacucaaacauccuucccugugauggaggaugguagaaagcccaggacaacucaggcccggaucuucacgacuguug 15 ucauuugccagccugauuuugauccaagagaagcaucucauugcccacuggcuucuucaacaaagaggugcuuaacaaaagg cucaggacuaucuuugaagacugaagauaaccuuccaggagaggagacucggacauugguacaggaggccccuuuuggcgg gggacacagcucuuugcgcucucuugauggcauggcauaguagaggcccccuccaacccggaacauggagcaacacaaaggg agagcaaagaaacugacgugcgucgacucauaggacauggguggcugcgggcacagaaagggaugccuccuguugccuggac aggacaguuggcugggaaggaaagagaaaauugaucuucauaagacaaagggccugaugggauggcaauagaaggacuuacc 20 agaccugcagggucaguauacccaucaccccgcacaacauccccagcccccaacucaaacuucaauauaucuuaggccaguau ccuagaccuaagucucuccuuucugccauuauuucuccgcaucuugagcagucaucugacugagauuugccaaguggauac ugggguaccacugccccccaagaaaagacugagccaggaacugccuacucgcucccccucccgagccuggagcuaacuccugu gaggggugcucucuucaccccacaacuuacuagaccuugagugagccucugucccuuaugugggcucuucgcugugagcca cagauggaggucauuguauagacaguuagccuuccccaggucagccuaccucccccaaacuugugagucuccccgcugcuca 25 uauggagaggcaugucuaagacagcaagucuucuagaggaagcuugccuuuaacagacagauggaacuaaaccuuccaaaug ggagaucuggcugaacccaggauacagagaccauggacauggauggggucaucaagagaagagggauguccuucuccagguu agggagagagaaggcaaguuugcaacgaucccaucaugcccugagcaagaagcuuuuggcccaggcuagccuuuaacuccau uagaggccucucuguuggguuuauccacagcaguaggcccaaguauggccuguccccaccucuacuaucccguggaagguu ucuucccaccccuuuuugacaaaugccucacucgagcaguggaaagauagcucucuucccccucuucugccagguaacaaag 30 agaccuaaccaggaccuauucuccaccccagccagucuugaccagccagaacaaagcagggaaccuggagaauaaaagacucu acguuccucugacaaagacucuacguuucucugacggccaggccuaaacagacaaggcuugggaacaucugccccacaggau acggaggaggucagcugugcucacuccucuucuccuuccaagacccucuuccgaccaugacuuaucuccaugguaacauccu caccaucauucucccacuaccaaggguugccauggcaaccucccaaccaccugcccaucccaggcaggcagcuguccuucugc ucagaacccuagaggacucuaggugaaauuuuacagcuuaagagaggagugagccaaggagaagagacccuguaguccucug 35 gcuuucaagagaaagaaggcuaugauuuaaaacacaguagaagggaaagaggucucgucgaggucgaccucucccggggagc uuagggguuguacugucuuuauuuuuuaaaccacuaaagugcaaunuuuccugcacucuuguuaccccgccucucuucccu guuagguuuucauuuccuugagcagacuuucuugguuuuuuaauggaguauagacuuucaccacuucacagacucuggccu ccucuccaagucucucuggauggggaaaaggaagguagagggucagaggggaaggggucccucgucaccccgcauccauuca cccccacuucucuggucccuagucaccggcuucaccccnaucuccgacaccaucacugucacacaguagccugucacacggau 40 aguacaguucagacaagacuccuucagauuccgagacgccuaccgguuguuuuugguuuuuguuuuguuuucuuuuguuu guuuguuuguuuguuuuuuacaacagcaauaaccacaucacauauuacuguagcucucuauaguguuacguucagacaccg uagcucuguccucucuuauuuuguugguuuugacuuaaaaaaaaauacuuaugcuuuuuacuggugaaacagauugaaaaa aaaauugaacaacaaaccaguuugugaaaaaaaaaaaaaaugugaaaaaaaaucaccccgauguggaagagcucggcuccucu uuagcauuuuguacuuaaggaaauaaaaaagaaaaaccuggaagaucucacauuuuauuacaaagugaaaaaaaaa - 172- Myoc/ 111 Sequence below. 247 trabecular meshwork induced gluco corticoid protein AF041335 guccagucugcagucuguauucggaagacauagauacuaaauacauggcaacucuuuuuuuuguuuguuuuaauucaucag gauguggagcgcuagucuggguaggagagccagucacccugaggacagcugaaacaaucgcuggcaaguauggagugugga ugagagaccccaagcccacccaccccuacacccaggaaagcacauggaggauugacacgguuggcacagagauccgccaggug uuugaguacagucagauaagccaguucgagcagggcuauccuuccaagguccaugugcucccucgggcacuggagagcacgg 5 gugcugugguguaugcggggagccucuauuuccagggggcugaguccagaacuguggucagguaugagcuagacacggaga ccgugaaggcagagaaggaaauuccuggagcuggcuaccacggacacuucccguacgcgugggguggcuacacagacauuga cuuagcuguggaugagagcggccucugggucaucuacagcacggaggaagccaagggggccauaguccucuccaaauugaac ccagcgaaccuggaacuugagcguaccugggagacuaacauccguaagcagucuguggccaaugccuuuguuaucuguggca ucuuguacacggugagcagcuacucuucagcccaugcaaccgucaacuucgccuacgacacuaaaacggggaccaguaagacc 10 cugaccaucccauucacgaaucgcuacaaguacagcaguaugauugacuacaacccccuggagaggaagcuguuugccuggg acaacuucaacauggucaccuaugauaucaagcucuuggagaugugaggagccucuaugccuaccagcaaaggccagaaaag gugaaguuccgggcucccgggugaagcagcugucagcagaggcagccagaugcauggaguuucuccuccugcuaaagauuu uguuuauccgggucaauguacagcuagcuccccucugacugacacguccuccaggcuuguauagucgcauagacucuguuc ucuucugucagcuuucaaagggcuguuccucuuuuaaaaaucacauagug Itm2a/E25 30 Sequence below. 248 putative Integral membrane protein 2A L38971 15 gggagaccugagcucgcugcugccuguggaagacugggagaggagacacuaagugcugcucaagcaagcgcgauccucuccu cuuucaaccugcagcccaagauacugauucgagccgcgccuuaccgcgcagcccgaagauucaccauggugaagaucgccuu caacaccccuacggcggugcaaaaggaggaggcgcggcaagauauagaggcgcucgucagucgcacuguccgagcucaaauc cugacuggcaaggagcucagaguugucccgcaggagaaagauggcucaucugggagaugcaugcuuacucuccuaggccuc ucauucaucuuggcaggacugauuguugguggagccugcauuuacaaguacuucaugcccaagagcaccauuuaccauggu 20 gagaugugcuucuuugauucugaggauccugucaauuccauuccuggaggagagccauacuuucugccugugacugaggag gcugauauccgugaggaugacaacauugccaucauugaugugccugugcccaguuucucugauagcgauccggcggcaauu auucacgacuuugagaagggaaugacugcuuaccuggacuugcuuuugggaaacuguuaucugaugccccucaauacuucc auuguuaugacuccaaagaaucugguggaacuuuuuggaaaacuggcaaguggcaaguauuugccucauacuuaugugguu cgugaagaccugguugcuguggaagaaauucgugauguuaguaaccuugguauuuuuauuuaccaacuuugcaacaaccga 25 aaauccuuccgccuuagacgcagagaccuucugcuggguuucaacaagcgugccauugacaaaugcuggaagauuagacacu uccccaaugaauuuaucguugaaaccaagaucugucaggagugaaaugugacagauaaagaguauccuugauaauaagaagu caggaacuuaccgucugacuuggaaaauugaaauugaugggauacucaugcuauuuacucauacauuuacucuauugcuua uacuggaaaaggaaagggaaaggggggagaaaacuacuaaccacugcaagcgauuguccaauucuacuuuaauugacauug - 173 uugcuguuuucaacaagucaaaugauuaucuuuucucuugaauuuauaggguuuagauuucugaaagcagcaugaaugug ucaucuuaccauccugacaauaaagcccauccucugguuuuauuuaaagcaagcucuuuccaacaucacuuggcuagagcau gcuuuaaauuuaaaauauuugaaauuuguuuuugacauuuuuuugugugaaacaugucaaaucucuuaccauucuuuggu uuucuucuuuauuauguucaacucuccugauuucagaaguuacauuuuugcauuucuaucaggugcuguguaacgaaucu 5 gacugauaugugaacaaucuucaugaggaagcaauuuuuuacucauguaaugauucuuucucacugauaucuguauuguga aauccacagaacuguacaggugcugaaugcuguaaggaguucugguuguaugaauucuacaacccuauaauaaaguuuaccg uauucaauca Eps8/ 15 Sequence below. 249 epidermal growth factor receptor pathway substrate 8 L21671 I II ggccauuaccaaucgcgacccgcgcacacacggcccgggcggcgggcgaagcgggcucccggggcgcugggcgcagggcgcgg ggcaagccccagcagcgugucugcaacggggcgcggcgggcgcuccagcuccgggaucuuucucccucggucaccucccucg 10 cgucuagggaggucguggcacucccugaggagcgcggcugcucggagggcggauccuagaacagaggcgugagagccggcau gaauggucauaugucuaaccgcuccaguggguauggagucuacccuucucaacugaaugguuacggaucuucaccacccuau ucccagauggacagagaacacagcucaagaacaagugcaaaggcccuuuaugaacaaaggaagaacuaugcccgagacagugu cagcagugugucggacgugucccaguaccgcguggaacacuugaccaccuucgugcuggaucggaaagaugcaaugaucacu gucgaggacggaauaagaaagcugaaguugcuggaugccaagggcaaaguguggacucaagauaugauucuccaaguggaug 15 accgagcugugagccugauugacuuagagucaaagaaugaauuggagaauuuuccucuaaacacaaucucgcauugucaagc aguggugcaugcaugcagcuaugacuccauucucgccuugguaugcaaagagccaacgcagagcaagccagaccuucaccuu uuccagugugaugagguuaaggcaaaccuaauuagugaagauaucgaaagugcaaucagugacaguaaaggugggaaacaga agaggcggccggaggcccugaggaugauugccaaagcagauccuggcaucccuccuccucccagagcuccugccccugugcca ccggggacugucacacagguggacguuaggagucgcguagcagccuggucugccugggcagcugaccagggugacuucgaga 20 agccccggcaguaccacgagcaagaagagacgcccgagaugauggcagcccggaucgacagggaugugcaaaucuuaaaccau auuuuggaugacauugaauuuuuuaucaccaaacuccaaaaagccgccgaagcguuuucugagcuuucuaaaaggaagaaaa guaagaaaaguaaaaggaaaggaccuggagagggcguuuuaacacugagggcaaaaccgccaccuccugacgaguuuguugac uguuuccagaaguuuaaacauggauucaaccuucuggccaaguugaagucccauauccagaacccgagugcuucagaucugg uucauuuuuuguuuacuccacuaaauauggugguccaggcaacagguggcccugaacuggccaguucgguacucagcccacu 25 guugacaaaagacacaguugauuucuuaaacuacacagccacugcggaggaacggaagcuguggaugucacugggagauagu ugggugaaagugagagcagaguggccgaaagaacaguucaucccaccuuacgucccgagguuccgcaacggcugggagccccc gaugcugaacuucaugggcgcgcccacagagcaagacauguaucaacuggccgaguccguggccaacgcagaacaccagcgca aacaggacagcaagaggcuguccacagagcauuccaauguguccgacuauccuccagccgacggauaugcguacaguagcagc auguaccacagaggaccacaugcagaccacggggaggcugccaugccuuucaagucaacuccuaaucaccaaguagauaggaa 30 uuaugacgcagucaaaacacaacccaagaaauacgccaaauccaaguacgacuuuguggcgaggaacagcagcgagcucucgg uuaugaaagaugaugucuuagagauacucgacgaucgaaggcagugguggaaaguccggaaugccaguggagacucuggguu ugugccaaauaacauucuggauaucaugagaacuccagaaucuggaguggggcgcgcugaccccccauacacacauaccauac agaaacaaaggacggaauacggccugagaucagcugacacuccuucugccccaucacccccuccaacgccagcacccguuccgg ucccccuuccaccuucuguaccagcacccguuucugugcccaagguuccagcagaugucacccgccagaacagcagcuccagu 35 gacagugggggcagcauugugcgggacagccagagauacaaacaacucccaguggaccgaaggaagucccagauggaagaggu - 174ucaggaugagcucuuccagaggcugaccaucgggcgcagugcugcgcagaggaaguuccacgugccacggcagaacguucca gugaucaauaucacuuaugacuccucaccggaagaaguaaagacuuggcugcagucaaagggauucaaucccgugacuguca auagccucgggguguugaacggagcacaacucuuuucucucaacaaagacgaacugaggucugucugcccggaaggugccag agucuuuaaccaaaucacuguucagaaagcugcuuuggaggacaguaauggaagcuccgaguuacaagagaucaugcggaga 5 cggcaggagaagaucagcgccgcugcgagcgacucgggaguggagucuuuugaugaagggagcagccacugaguccaugaac uuccuuauucuugguguggucguugaacagugauggacaugcuuuguuuuaagaagccuugaagggaaugucaaagcuguc gucuugguauauguaauuuaucgccauauaaggaaacaguauaugccugaguaagcagaggacccgcugcuucugugcacau uaguuugauuaaaacugagaagcggguaggugagauggcucagcaaguaaaggugcuugcugccaagcccaaugacccaagu ucgagucccugggucuacaugguaggagagagcuggcuucugcaaguuguccucugaccaccacacauaaauaaauaacaaa 10 uguaauuuacaaacuuuuaaaagaaaauguaauuuaaaaaaccagacguucuagacuguucugggcuugggaaauauuuuu uucacuuuccuaagguguacuuuccuuugcuacauuaauuauugcagccuuguucgaugaucuaaguggggauauuugaca auggcagauuuauucauugcaacaaggaaagacacagccauugaugaaaaaaaaaagaaagucucagcuuucagugacuggga uaccugcuguccagggaggaggcucaguuagacuacccucugcuuacuugaggucugacaugcccaaugagaguguauuuag cuuuauuuaaaguucuuaaugccaacaguuuuaaaaaucacauuuaaaugaacuguacaagguagccagaccuugaauguau 15 gaauagacuauauaauaugucccgagaaacuuuguuacucucagcucuguugauugcgaaaucuugcauagauuaugcuuu gauuuaguuucu - 175 - Fyn/Fyn 10 Sequence below. 250 proto oncogene M27266 ccugggccccgccgcggacgcgcggagccgccugggccgcgccggaggagggcggggagaggaccaugugaaugugcuccg gagcugagcgccaagccaagcaguguuugaaaggaacaggaugcugaucuaaucguggcaaaaagucaguccgaccgcuggu uucgaagacaugugguguauauaaaguuugugauaguugguggaaauuugggagcuuggauaaugggcugugugcaaugu 5 aaggauaaagaagcagcgaaacugacagaggagagggacggcagccugaaccagagcucuggguaccgcuauggcacagaccc caccccucagcacuaccccagcuucggcgugaccuccaucccgaacuacaacaacuuccacgcagcugggggccagggacuca ccgucuuugggggugugaacuccuccucucacacugggacccuacgcacgagaggagggacaggagugacacuguuugugg cgcuuuaugacuaugaagcacggacggaagaugaccugaguuuucacaaaggagaaaaauuucaaauauugaacagcucgga aggagauuggugggaagcccgcuccuugacaaccggggaaacugguuacauucccagcaauuacguggcuccaguugacucc 10 auccaggcagaagagugguacuuuggaaaacuuggccgcaaagaugcugagagacagcuccuguccuuuggaaacccaagag guaccuuucuuauccgcgagagccaaaccaccaaaggugccuacucacuuuccauccgugauugggaugauaugaaagggga ccacgucaaacauuauaaaauccgcaagcuugacaaugguggauacuauaucacaacgcgggcccaguuugaaacacuucagc aacugguacagcauuacucagagaaagcugaugguuuguguuuuaacuuaacugugguuucaucaaguuguaccccacaaa cuucuggauuggcuaaagaugcuugggaaguugcacgugacucguuguuucuggagaagaagcuggggcagggguguuuc 15 gcugaaguguggcuugguaccuggaauggaaauacaaaaguagccauaaagacccuuaagccaggcaccaugucuccggagu ccuuccuggaggaggcgcagaucaugaagaagcugaagcaugacaagcuggugcagcucuacgcggucgugucugaggagcc cauuuacaucgucacggaguacaugagcaaaggaaguuugcuugacuucuuaaaagauggugaaggaagagcucugaaguu gccaaaccuuguggacauggcggcacagguugcugcaggaauggcuuacaucgagcgcaugaauuauauccacagagaucug cgaucagcaaacauucuaguggggaauggacuaauuugcaagauugcugacuuuggauuggcucgguugauugaagacaau 20 gaauacacagcaagacaaggugcgaaguuucccauuaaguggacagcccccgaagcggcccuguauggaagguucacaauca agucugacguauggucuuuuggaaucuuacucacagagcuggucaccaaaggaagagugccauacccaggcaugaacaaccg ggaggugcuggagcagguggagagaggcuauaggaugcccugcccacaggacugcccgaucucccugcacgagcucaugauc cacugcuggaaaaaggauccggaagagcgcccgaccuucgaguacuugcagggcuuccuggaggacuacuuuacggccacag agccccaguaucagcccggugaaaaccugugagagccugcgcuucagacgccucuucccgaggccucccuaccccuccccauu 25 agcuuccaauucuguagccagcugccccagagcaggagaaccguccaggaucagauugcaugugacucuugaagcugaacuu ccacggcccucauuaaugacacuugucccccaguccgaaccuccucugugaaccaucugagacagaagcguguuauuucuca gacuuggaaaugcauuguaucgauguuaugucaaaggccaaaccucuguucaguguaaauagcugcuccugugccaacaauc ccagugcuuuccuuuuuuaaaaaagaaaaagcaaauccuaugugauuuuaacucugauuucaccugauucaacuaaaaaaaa aaaaguauuauuuuccaaaaguggccucuuugucuaaaacaauaaaauuuuuuuucauguuuuaacaaaaaaaaaaaaaaaa 30 aaaaaaaa - 176- Structurally-related Col6al/ 36 Sequence below. 251 Procol lagen, type VI, alpha 1 X66405 cccucccuggcucucuccucagcucugggcucugacugcagcaagcagagacaaccucucacucugccuuucccagcgcccac ccugacccuggcccacauuugacggugacucgcaggccagccagaaacaugaggcuggcccacgcucugcugccccugcugc uacaagccugcuggguggccacacaggacauccagggcuccaaagcgauugccuuccaagacugcccuguggaucuauucuu 5 cgugcucgacaccucggagaguguggccuugaggcugaaaccuuauggggccuugguggacaaggugaaguccuucacuaa gcgcuucauugacaaccugagagacagguacuaccggugugaccgcaaccugguuuggaaugcgggugcgcugcacuacag ugacgagguggagaucauccgagggcucacgcgcaugcccaguggccgcgaugagcucaaggccagcguggaugcggucaag uacuucgggaaaggcaccuacaccgacugcgccauuaagaaggggcuggaggagcugcucauagggggcucccaccugaagg agaacaaguacuugaucguggugaccgacgggcauccucuagagggcuacaaggaaccaugcgggggucuggaagaugcagu 10 aaaugaggccaaacaccugggcaucaaggucuuuucuguggccaucacaccugaccaccuggagccacgucuaaguaucauu gccacagaccacacauaccggcgcaauuucacggcagcugacugggggcauagccgcgaugcagaagaggucaucagccagac cauugacaccauuguggacaugauuaaaaauaacguggaacaaguguguuguucuuuugagugccaggcugccagaggacc uccagggccccgaggcgacccuggguaugagggggagcgaggaaagccaggucuuccgggagagaagggagaagcuggagac ccuggacgaccuggggaucuuggaccagucggguaccaggguaugaagggagaaaaggggagccguggagagaaggguucc 15 agaggaccgaaagguuacaagggcgagaaaggcaagcgcggaaucgacggggucgacggcaugaagggagagacgggguacc caggacuaccgggcugcaagggcuccccaggauuugauggcauucaaggacccccgggucccaagggugaugcuggugccuu ugggaugaagggagaaaagggugaagcuggagcagacggugaggcugggagaccagggaacucagggucaccuggagauga gggugauccuggagagccugguccccccggagaaaaaggagaggccggugaugaaggaaaugcuggcccagacggugccccu ggagagagggguggcccuggugaaagaggaccucgggggaccccuggugugagaggaccaaggggagacccgggugaagcu 20 ggaccacagggugaccaaggaagagaggggcccgucggcaucccuggagacucgggugaggcuggccccauuggaccuaaag gauaccgaggugaugaggguccuccagguccugagggccucagaggagccccaggaccuguugguccuccuggagaccccgg acugaugggugagagaggugaggauggaccaccaggaaacggcacggaagguuuccccggcuucccuggguauccaggcaac agaggcccuccugggcuaaauggcacaaaaggcuacccuggccucaagggggaugagggugaagugggagacccaggagagg auaacaacgacauuucaccccguggggucaaaggggcaaagggauaccgaggcccagaaggaccccagggaccuccaggacau 25 gugggaccaccugggccagaugagugugagauccuggauaucaucaugaaaaugugcuccugcugugagugcacaugugga cccauugacauccucuucgugcuggacagcucggagagcauuggccuacagaacuuugagauugccaaggacuucaucauca aggucauugaccgguugagcaaggaugagcuggucaaauuugagccagggcagucucacgcgggcgugguacaguacagcc acaaccagaugcaagagcacguggacaugcggagccccaacguccgcaacgcccaggacuucaaagaagcugucaagaagcua caauggauggcugguggcacauucaccggagaagcgcugcaguacacccgggaccggcuacucccacccacacagaacaaccg 30 aauugcccuggucauuacggauggacguucugacacucaacgggacacgacaccucucagugugcucuguggugcagacauu cagguaguuucugugggaaucaaggauguguuuggcuuuguggcgggcuccgaccagcucaaugucauuuccugccaaggc uuaucgcaaggucguccagguaucucccuggugaaggagaacuaugcagagcuucucgaugacggcuuucugaagaacauaa cagcccagaucuguauagauaagaaguguccggauuauaccuguccaaucacauucuccuccccggcugacaucaccauccu gcuagacagcucagccagugucggcagccacaacuucgaaaccaccaaggucuucgccaagcgccuagcugagcgauuccug 35 ucagcaggcagggcggauccuucccaggaugugcggguggccgugguacaguauaguggccaggggcagcaacagccaggu cgggcggcucuucaguucuuacagaauuacacagugcuggccagcucuguggacagcauggauuucaucaacgacgccacag acgucaacgaugcucugagcuacgugacucguuucuaccgggaagccucgucaggugccaccaagaagagagugcuguugu - 177uuucagacggcaacucucagggggccacagcagaggccauugagaaggcugugcaggaggcccagcgugcaggcauugagau cuuuguggugguggugggaccccaggugaacgagccccacauccgugugcuugucacuggcaagacugcagaguacgacgu ggccuuuggcgagcgccaccuauuccguguaccaaacuaccaggcccugcuacguggcguacucuaccagacagucuccagg aagguggcacugggcuagagggccacacacguggcuggacacacauggcauggagacacauuucaacaggccuucccgcccu 5 ucccacugacaaaacaggaauaggaaaugugacccaacuggucaacucaacugucuuaaagggaacgcugagaugcacacucu uugcuuuguguaauguccccuguggcucaccugagcuccuaucuagaucccgcccuugguuuguacaucaugguggccauc uugcugaccccucccccaucugggacuggauccagccaucucgucuuccuccucacugccccuaaccuauccguggugucuu cacaccaucacugcaguuuccgucuguguucugucuuccaugcucaacaugaagcagaccuucucaugaguucagcuugcug gauuauggcuuuuaggaaauugaacacaggaggaguuccaaacacaaacuuggaggagaccccuccucuucaucaggugcuu 10 gucagugaccuacaugcaucuuggucugguccuuaguggcuaguccuuccacucugaaagcaaaggugcuaucuaucugua agggcucucucuacacacccagaggcuuagcuuggacaguucacacucaaguguccugucagaaucaauccagagcuuucuc ccucaaaauagugacuugucucccccugguccccaaaggcuccccuuuaguuaguuucuucauggcucccccacauuccccg uaaucugauccaagccagcuaucucugcuaauaaagguuuccauuuuucaaaaaaaaaaaaaa Tnc/ 17 accccaugccccacccccaccuucgauguuuugaacauuucuaacaacug 252 Tenascin C aagccaguaaagucauauucuuuaaauuuccaggacauucauauuauuc acauaaucauggucauggugaugauggaaacugaggacuuuaaaagaga AV230686 uuuucccuucccaaacguuucuggacaguaccugauuguauuuuuuuug X56304 uuuuguuuuguuuuuuaauaaaagcacaguacuuuucc Krt2-6a/ 10 Sequence below. 253 Keratin complex 2, basic, gene 6a (keratin 6a) K02108 gucugcccugccguuucucuacuucccagccuucucaucuccaggaaccaugucuaccaaaaccaccaucaaaagucaaacca 15 gccaccguggcuacagugccagcucagccagagugcuuggacucaaccgcucgggcuucagcaguguguccgugugccgcuc ccggggcagcgguggcuccagugcaauguguggaggagcuggcuuuggcagcaggagccucuaugguguggggagcuccaa gaggaucuccaucggagggggcagcuguggcauuggaggaggcuauggcagccgauucggaggaagcuucggcauuggugg uggagcugguaguggcuuuggcuucggugguggagcuggcuuuggugguggcuaugggggagcuggcuucccggugugc ccacuuggaggcauccaagaggucaccaucaaccagagccuccucacaccccugaaccugcaaauugaccccaccauccagcg 20 ggucaggacugaggagagggagcagaucaagacccucaauaacaaguuugccuccuucaucgacaaggugcgguucauggag cagcagaacaaggucauggacaccaagugggcccugcugcaagagcaggacaccaagaccgugaggcagaacauggagcccau guuugagcaguacaucagcaaccuccgcagacagcuggacagcaucauuggagagaggggucgcaugaacucagagcugagg aacaugcaggaacucguagaagaacuacggaacaaauaugaagaugaaaucaacaagcgcacagacgcagagaaugaauucgu gacccugaagaaggauguagaugcugccuacaugaacaaaguugaacugcaagccaaggcagacagucuaacagaugauauc 25 aacuucuugagagcucucuaugaagcagaacugucucagaugcaaacucacaucucagacacaucugugguccucuccaugg ucaacaaccguagccucguccuagacagcaucaucgcugaggucaaggcccaguuugaggucauagcucagagaagucgggc ugaagcugagucauuguaccagacuaaauaugaggagcugcaggucacagcuggcagacauggggacgaccugcgcaacacc aagcaggagauugcugagaucaaccgcaugauccagaggcugagaucugagaucgaccacguuaagaagcagugugccaacc ugcaagcugcuauugcugaugcugagcaacguggggagauggcccugaaggaugcaaggggcaagcuggaagggcuggagg 30 augcccugcagaaggccaaacaggacauggccaugcugcugaaggaguaccaugaacucaugaaugucaagcuggcccuuga uguggaaauugccaccuacaggaagcugcuggaaggagaggagugcagguugaauggugaagguguuggaccagucaacau - 178cucuguggugcaguccaccguguccagcggcuauggcagugccgggggugccagcagcagcuuaggcauggguggaggcag cagcuacuccuauagcagcagccauggccuuggagguggcuucagugcuggcaguggcagagccaucggagguggccucag cucuucugguggccucagcucuucuaccaucaaauacaccaccaccuccuccagcaagaagagcuacaggcagugaauucug ucaccaagagcuugucucuggucccagaugucauggcugcagcugaaccacaugcuuugguucccggaagggaacgaauccc 5 aaccucuggccuccccauggcucaguucuacauuuguguugcacgucagcaccuauacauguucuuuggugacccagacccc aaaauguugcagaauguagaccuccaagacgaaaccccaaacccuacccagaauacccaccuaaauucugucaugguucugac uuccuccagagucuguaaaauaaaaugcccccacaacaaac Channel-related Potassium 14 uuuuuuuuuuuuuuuuugauuuuaauuacaaacuuuauuuguccuc 254 channel, caguucacaguuuauacgugguacaucccaccaugucagcuuccagaa subfamily cggcuauucaggagauggguggagcuuucuuuguaaaggaacccgac K, member auuuuaaaauuuugguuagaaucuucauagguuuauaaaaguacucu 2 cugcaagcgaacuggauauauuuacauuuauagcuuaaauucaaauu uuggaaaauaggaaucuuuuuguguuuuuaaacauccuggguuuau A1849601 gucuuaagacuuuacucugaaugccacaugaucacguaagcccaagcc ucccccagaagggaaaaaucaguuuugc Skd3/ 4 uuuuuuuuuuuuuuuuugggugccaugccacagcaaggggccuuua 255 Suppressor uuagauguucagggcacagacagguggaugcuagaugguguagcaca of K+ ccuucucaggguggaguggugccuggauguccaguuugcgggucuu transport gcuguccuuaucaaugaucuccagucgcaauguagguggacgcuucu defect 3 cagccuggggugagggcagcucacggcucuugaggaggugcuugucc gaauccuccacagugauacccagggugcaacccccugg A1837887 Clic4/ 3 uuuuuuuuuuuuuuucugacacaguaguaauccuuccagacuccuua 256 Chloride cacaauauuacaacucccccaguacauaaauguuccuauaccaugcaca intracellular cagcaacaugggguccacugaugucgcaggcgacuuuucuaauggug channel gaacauagcaccucaaguucugccaucuacacagugaagggacgugau (mito- ggucggggcuccagagugacagcaaacugccucuugggugacacgcu chondrial) uguggcgaagugccucc A1845237 Coll8al/ 5 Sequence below. 257 Endostatin (alpha 1 (XVIII) collagen) L22545 gagaauguugcugaggagguggggcugcugcagcuccuuggagacccccuaccugagaagaucucacaaaucgaugacccuc acgucgggccggccuacaucuuuggaccagacuccaacaguggccagguggcccaguaucauuucccaaaacucuucuuccg 10 ggacuuuucgcugcuguuucauguccggccagccacagaggcagcaggggugcuauuugccaucacagaugcugcccaggu gguagucucacugggcgugaagcucucagagguccgagauggacagcaaaacaucucauugcucuacacggagccuggggcc agccagacccagacgggagccagcuuccgccuaccugcauuuguugggcaguggacacacuucgcgcucagcgucgacggag gcucuguggcucucuacguagacugugaagaauuccagagggugccauuugcucgggccucgcagggacuggagcuagagc - 179guggcgcuggccucuuugugggucaggcuggaacagcagacccugacaaguuccaggggaugaucucagagcugaagguac gcaaaaccccccgggugagcccugugcacugucuggaugaagaagaugaugaugaagaccgggcaucuggagauuuuggaag uggcuuugaagaaagcagcaagucacacaaggaggauacaucucuacuaccugggcucccucagccaccuccugucacuucc ccaccccuggcuggaggcagcaccacagaagauccuagaacagaagaaacggaggaagacgccgcgguagauucuauaggagc 5 ugagacccuuccuggcacagguucaagcggugcaugggaugaggcuauccagaaccccggaaggggcuugauaaagggagg uaugaaaggacaaaagggagaaccaggugcccagggcccaccuggcccagcuggcccccaggguccugccgguccagugguc cagagccccaacucacaaccugucccuggagcacaaggacccccgggaccucaggggccaccagggaaggauggcacuccagg aagggauggugaaccgggugacccuggugaagaugggagaccgggugacacuggaccucaaggcuuuccagggaccccagga gaugugggcccuaagggcgagaagggagauccugguauugggccccgaggaccuccagggccuccagggccaccaggacccu 10 ccuucagacaagacaagcugaccuucauugacauggagggauccgguuucagcggagacauagagagccuuagaggcccacg aggcuucccuggccccccggggcccccuggugucccaggacuuccuggugagccaggacgcuuugggaucaaugguuccua ugcaccaggaccugcaggccuuccugguguaccugggaaggaaggaccccccgguuuuccaggucccccgggaccuccaggu ccuccaggcaaagagggcccaccaggaguggccggccagaaaggcaguguuggugaugugggcaucccaggacccaagggga gcaaaggagaccuugggcccaucgguaugccuggcaagucuggcuuggcuggauccccugggccaguuggacccccaggacc 15 uccagggccuccagggccaccaggaccaggauuugcugcuggauucgaugauauggaaggcucuggaauaccccucuggaca acagcccgaagcucugaugggcugcagggaccucccgggucgccgggacucaagggggauccuggaguggcaggccuaccug gagccaagggagaaguuggagcagauggagcccagggcaucccuggucccccaggaagagaaggugcagcuggaucuccggg gccaaaaggagagaaggggaugccgggagaaaagggaaacccaggaaaagauggagugggccggccgggccucccugggccu ccaggaccuccagggcuggugaucuaugugucaagugaggauaaagcaauagugagcacgccaggaccugagggcaagccag 20 gguacgcaggcuuuccuggaccugcuggaccgaagggugaccuggguuccaaaggcgagcagggucuuccgggguuuaagg gugagaagggagagccaggcacuaucuuuaguccugauggcagacgucugggccauccccagaagggagccaagggagagcc aggcuuucgaggacccccggguccuuauggacgaccugggcacaagggugaaauuggcuucccuggacggccgggucgacc uggaacgaauggcuuaaagggagagaagggagagccuggagaugccagccuuggguucagcaugaggggauugccuggccc cccugggccuccaggacccccagguccuccugggaugcccaucuaugacagcaaugcauuuguggagucuggccgaccugga 25 cuaccaggacagcagggugugcaggggccuucaggaccaaagggugacaaaggagagguggggccaccugggccaccagggc aauuccccauugaccucuuccaccuggaagcggaaaugaagggggacaagggagaccgaggggaugcuggacagaaaggaga gaggggagaaccuggggcuccuggugguggauucuucagcucaaguguaccuggcccacccggcccaccuggauacccugga auuccggguccaaagggagagagcauccgggggccaccuggcccuccuggcccgcagggaccuccuggcauuggcuaugagg gucgccagggucccccaggaccuccaggaccuccaggaccucccuccuucccuggcccucacagacagacugucaguguuccu 30 gguccuccgggcccaccugguccuccaggucccccaggagccaugggugccucugcugggcaggugaggaucugggccacau accagaccaugcuggacaagauccgggaggugccggagggcuggcucaucuuuguggccgagagggaagagcucuauguac gcguuagaaauggcuuccggaaggugcugcuggaggcccggacagcccuccugagaggcacgggcaaugagguggcugcuu uccagcccccauugguccagcuucaugagggcaguccauacacccggagggaguacuccuauuccacggcacgacccuggcg agcagaugacauccuggccaacccaccgcgccugccagaccgccagccuuacccuggaguuccacaucaccacaguuccuaug 35 ugcaccugccgccagcccgccccacccucucacuugcucauacucaucaggacuuucagccagugcuccaccugguggcacu gaacaccccccugucuggaggcaugcgugguauccguggagcagauuuccagugcuuccagcaagcccgagccguggggcug ucgggcaccuuccgggcuuuccuguccucuaggcugcaggaucucuauagcaucgugcgccgugcugaccgggggucugug cccaucgucaaccugaaggacgaggugcuaucucccagcugggacucccuguuuucuggcucccagggucaagugcaacccg gggcccgcaucuuuucuuuugacggcagagauguccugagacacccagccuggccgcagaagagcguauggcacggcucgga 40 ccccagugggcggaggcugauggagaguuacugugagacauggcgaacugaaacuacuggggcuacaggucaggccuccucc cugcugucaggcaggcuccuggaacagaaagcugcgagcugccacaacagcuacaucguccugugcauugagaauagcuuca ugaccucuuucuccaaauaggccucugccagcuaggguggcagacagaggccaugcagaacuuugacacagcgcagggagca uucagucagcacccagggcucuggcugggauacaacuccuguauaguucccauuuuuauguaauccucaagaaauaaaagga agccaaagaguaaaaaaaaa -180 - [000220] Table 5. Genes down-regulated in HF stem cells. Gene Fold Sequence SEQ Name/protein Deer ID No. Growth Factors, Receptors and Downstream genes GNA-14 32 Sequence below. 258 Mouse G protein alpha subunit (GNA 14) M80631 aacugccuucgagaagcguuagccuagagauccgagccucuucuccauaccauaguugguucaggugguuuccucuucaaac cuugcgucugcggauaauccgcgcggccgggcguuaagcuccaggucccugucgcuccgucgagguggcaagccauggccg gcugcugcuguuugucugcggaggagaaagagucucagcgcaucagcgcggagaucgagcggcacguucgccgcgacaagaa 5 ggacgcgcgccgggagcucaagcugcuguugcugggaaccggugagagugggaaaagcaccuuuaucaagcagaugaggau aauccaugggucuggcuacagugaugaagauagaaagggcuucacgaagcugguuuaccaaaacauauucacggccaugcaa gccaugaucagagcaauggauacccugaggauacaauacaugugugagcagaauaaggaaaaugcccagaucaucagggaag uggaaguagacaaggucacugcacucucuagagaccagguggcagccaucaagcagcuguggcuggaucccggaauccagga guguuacgacaggaggagggaguaccagcugucagacucugccaaauauuaccugacggacauugagcguaucgccaugccc 10 ucuuucgugccaacacaacaggaugugcuucguguuagagugcccaccacuggcaucauagaauauccauucgaccuggaaa acaucaucuuccgaaugguggauguugguggccagcgaucugaacgacggaaauggauucacugcuuugagagugucaccu ccaucauuuucuugguugcucugagugaauaugaccagguucuggcugagugugacaaugagaaccgcauggaggagagca aagcccuguuuagaaccaucaucaccuaccccugguuucugaacuccuccgugauucuguucuuaaacaagaaggaucuucu agaggagaaaaucauguacucucaucuaauuagcuacuucccagaguacacaggaccaaagcaagaugucaaagcggccaggg 15 acuuuauccugaagcuguaucaagaccagaauccugacaaagagaagguuaucuauucucacuucacuugugcuacagacac cgagaauauccgcuuuguguuugcugcugucaaagacacaauccuacagcuaaaccuacgggaguucaacuugguguaaaug gagggccuacuccuccgagacagagggugaucugagcccuuccugccugaucuacaagugcuucuggaccaggaccuaagga cauuauguagcccacaggacagagauggguagugcaaugugaaaaauacuucaccaacccuuuuaagugucuuuaauucuuc acugucuaacucuuuucucgccuuuugguugaacgauuagguaucauuuuugagugguucccccucuccuauuuuuuuaa 20 acuaguguucaacaguuauuaaaaaaucaugc - 181 - Ly6/Lympho- 12 gaauucccugcaaccuugucugagaggaagcaaggacuggugugagg 259 cyte antigen 6 agggagcugugagguuuuaucugugcagcccuucucugaggaugga complex cacuucucacacuacaaaguccuguuugcugauucuucuuguggccc uacugugugcagaaagagcucagggacuggaguguuaccagugcua X04653 uggagucccauuugagacuucuugcccaucaauuaccugccccuacc cugauggagucuguguuacucaggaggcagcaguuauuguggguuc ucaaacaaggaaaguaaagaacaaucuuugcuuacccaucugcccucc uaauauugaaaguauggagauccuggguacuaaggucaaugugaaga cuuccuguugccaggaagaccucugcaaugcagcaguucccaaugga ggcagcaccuggaccauggcaggggugcuucuguucagccugagcuc aguccuccugcagaccuugcucugaugguccucccaaugaccuccac ccuuguccuuuuauccucaugugcaacaauucuuccuggagcccucu agugaugaauuaugaguuauagaagcuccaaggugggaguagugug ugaaauaccauguuuugccuuuauagcccugcuggguagguaggug cucuaauccucucuagggcuuucaagucuguacuuccuagaauguca uuuuguuguggauugcugcucaugacccuggaggcacacagccagca cagugaagaggcagaauuccaagguauuaugcuaucaccauccacac auaaguaucugggguccugcaauguucccacauguauccugaauguc ccccuguugaguccaauaaacccuuuguucuccc Bmp4/Bone 11 Sequence below. 260 morphogenetic protein 4 L47480 ggaagaaagagagggagggaaaagagaaggaaggaguagaugugagaggguggugcugagggugggaaggcaagagcgcga ggccuggcccggaagcuaggugaguucggcauccgagcugagagaccccagccuaagacgccugcgcugcaacccagccuga guaucuggucuccgucccugaugggauucucgucuaaaccgucuuggagccugcagcgauccagucucuggcccucgacca gguucauugcagcuuucuagagguccccagaagcagcugcuggcgagcccgcuucugcaggaaccaauggugagcagggcaa 5 ccuggagaggggcgcuauucugaggauucgaggugcacccguaguagaagcuggggauggggcucaggcuguaaccgaggc aaaaguuggccuauuccuccuuccuucuccaacaguguuggaggugggaugauggaggcuaaaaggcaccuccauauaugu uacugcgucuaucaaccuacuuuagggaggugcgggccaggagaggcgggaaggagagaaggccuuggaagagaggucauu gggaagaacugugggguuugguggguuugcuuccacuuagacuauaagagugggagaggagggagucaacucuaaguuuc aacaccagugggggacugaggacugcuucauuaggagagagaaccuagccagagcuagcuuugcaaaagaggcuguaguccu 10 gcuuugcucuaaagcgcgacccgggauagagaggcuuccuugagcggggugucaccuaaucuuguccccaacgcacccccuc ccagccccugagagcuagcgaacuguagguacacaacucgcucccaucuccaggagcuauuuucuuagacaugggcacccau gauucugccuucugguacucuccccucccugggaaagggguguaagguuccgacggaaccguggccaggaugccgaaaggc uaccugugcgggucuucugccaugcugugucugugcggacaugccagcagggcuaaugaggagcuugcgauacuccaaagg guucgggaauugcgggguccuuacacgcaguggaguugggccccuuuuacucagaagguuuccgccacggcuuugguugau 15 aguuuuuuuaguauccugguuuaugaacugaagguuuugugagauguugaaucacuagcagggucauauuuggcaaaccg aggcuacuauuaaauuuugguuuuagaagaagauucuggggagaaagugaaggguaacugccuccaggagcuguaucaacc ccauuaagaaaaaaaaaaauaccaggagaugaaaauuuacuuugaucuguauuuuuuaauuaaaaaaaaucagggaagaaag gagugauuagaaagggauccugagcgucggcgguuccacggugcccucgcuccgcgugcgccagucgcuagcauaucgcca ucucuuucccccuuaaaagcaaauaaacaaaucaacaauaagcccuuugcccuuuccagcgcuuucccaguuauucccagcgg 20 cgacgcgugucggggaauagagaaaucgucucagaaagcugcgcugaugguggugagagcggacugucgcucaggggcgcc - 182 cgcggucucugcacccagggcagcagugugggauggcgcugggcagccaccgccgccaggaaggacgugacucuccauccuu uacacuucuuucucaaagguuucccgaaagugccccccgccucgaaaacuggggccggugcggggggggggagagguuagg uugaaaaccagcuggacacgucgaguuccuaagugaggcaaagaggcgggguggagcgggcucuggagcgggggaguccug ggacucgguccucggauggaccccgugcaaagaccuguuggaacaagaguugcgcuuccgagguuagaacaggccaggcauc 5 uuaggauagucaggucacccccccccccaaccccacccgaguuguguuggugaauuucuuggaggaaucuuagccgcgauuc uguagcuggugcaaaaggaggaaaggggugggggaaggaaguggcngngcggggguggcgguggggguggaggugguuua aaaaguaagccaagccagagggagaggucgagugcaggccgaaagcuguucucggguuuguagacgcuugggaucgcgcuu ggggucuccuuucgugccggguaggaguuguaaagccuuugcaacucugagaucguaaaaaaaaugugaugcgcucuuucu uuggcgacgccuguuuuggaaucuguccggaguuagaagcucagacguccaccccccaccccccgcccacccccucugccuu 10 gaauggcaccgccgaccgguuucugaaggaucugcuuggcuggagcggacgcugagguuggcagacacgguguggggacuc uggcggggcuacuagacaguacuucagaagccgcuccuucuaacuuucccacaccgcucaaaccccgacacccccgcggcgga cugaguuggcgacggggucagagucuucuggcugaaaguuagauccgcuaggggucggcugccugucgcuagaagcauuau uuggccucucggagacccguguggaggaagugcuggagugugcgaguguguuugcgugugugugugugugugugugugu gugugugugugugugugugugcgcgcgcccuuggagggucccuaugcgcuuuccuuuucauggaacgcugucgugaggcu 15 uugguaaacugucuuuucgguuccucucucggcugcacuuaagcuuugucggcgcuguaaagagacgcgucuucaagugca cccugauccucaggcuucagauaacccguccccgaaccuggccagaugcauugcacugcgcgccgcagguagagacgugccc cacguccccugcgugcagcgacuacgaccgagagccgcgccaguguggugucccgccgagaguuccucagagcaggcgggga caacucccagacggcuggggcuccagcugcgggcgcggagguuggccucgcucgcaggggcuggacccagccgggguggga ggauggaggaggggcgggcgggcucuucggugaguggggcggggccucuggguccacgugacuccuaggggcuggaagaa 20 aaacagagccugucugcuccagagucucauuauaucaaauaucauuuuaggagccauuccguagugccauucggagcgacgc acugccgcagcuucucugagccuuuccagcaaguuuguucaagauuggcucccaagaaucauggacuguuauuaugccuug uuuucugucagugaguagacaccucuucuuucccuucuugggauuucacucuguccucccaucccugaccacugucugucc cucccgucggacuuccauuucagugccccgcgcccuacucucaggcagcgcuaugguucucuuucuggucccugcaaggcca gacacucgaaauguacgggcuccuuuuaaagcgcucccacuguuuucucugauccgcugcguugcaagaaagagggagcgcg 25 agggaccaaauagaugaaagguccucagguuggggcugucccuugaagggcuaaccacucccuuaccagucccgauauaucc acuagccugggaaggccaguuccuugccucauaaaaaaaaaaaaaaaaacaaaaaacaaacagucguuugggaacaagacucu uuagugagcauuuucaacgcagcgaccacaaugaaauaaaucacaaagucacuggggcagccccuugacuccuuuucccagu cacuggaccuugcugcccgguccaagcccugccggcacagcucuguucuccccuccuccuguucuuaaccagcuggaaguug uggaaauugggcuggagggcggaggaagggcggggguggggggguggagaaggugggggggggggaggcugaagguccga 30 agugaagagcgauggcauuuuaauucucccuccnccuccccccuuuaccuccucaauguuaacuguuuauccuugaagaagc cacgcugagaucauggcucagauagccguugggacaggauggaggcuaucunauuugggguuauuugaguguaaacaaguu agaccaaguaauuacagggcgauucuuacuuucgggccgugcauggcugcagcugguguguguguguguagggugugagg gagaaaacacaaacuugaucuuucggaccuguuuuacaucuugaccgucgguugcuaccccuauaugcauaugcagagacau cucuauuucucgcuauugaucgguguuuauuuauucuuuaaccuuccaccccaacccccuccccagagacaccaugauuccu 35 gguaaccgaaugcugauggucguuuuauuaugccaaguccugcuaggaggcgcgagccaugcuaguuugauaccugagacc gggaagaaaaaagucgccgagauucagggccacgcgggaggacgccgcucagggcagagccaugagcuccugcgggacuucg aggcgacacuucuacagauguuugggcugcgccgccguccgcagccuagcaagagcgccgucauuccggauuacaugaggga ucuuuaccggcuccagucuggggaggaggaggaggaagagcagagccagggaaccgggcuugaguacccggagcgucccgcc agccgagccaacacugugaggaguuuccaucacgaaggucaguuucugcucuuaguccuggcgguguagggugggguagag 40 crccggggcagaggguggggggugggcagcuggcagggcaagcugaagggguuguggaagcccccggggaagaagaguuca uguuacaucaaagcuccgaguccuggagacuguggaacagggccucuuaccuucaacuuuccagagcugccucugaggguac uuucuggagaccaaguagugguggugaugggggaggggguuacuuugggagaagcggacugacaccacucagacuncugcu accncccagnggguguucuuuagcuauaccaaagncagggauucugcccguuuuguuccaaagcaccuacugaauuuaaua uuacancuguguguuugucagguuuaucaauaggggccuuguaauacgaucugaauguuuccuagcggauguuucuuuuc 45 caaaguaaaucugaguuauuaauccuccagcaucauuacuguguuggaauuuauuuucccuucuguaacaugaucaacaag - 183 gcgugcucuguguuucuaggaucgcuggggaaauguuugguaacauacucaaaaguggagagggagagaggguggccccuc uuuuucuuuacaaccacuuguaaagaaaacuguacacaaagccaagagggggcuuuaaaaggggaguccaagggugguggag uaaaagaguugacacauggaaauuauuaggcauauaaaggagguugggagauacuuucugucuuugguguuugacaaaugu gagcuaaguuuugcugguuugcuagcugcuccacaacucugcuccuucaaauuaaaaggcacaguaauuuccuccccuuagg 5 uuucuacuauauaagcagaauucaaccaauucugcuauuuuuuguuuuuguuucuuguuuuuguuuuguuugguuuuuu uuuuuuuuuuuuuuuuuuugucucagaaaagcucaugggccuuuucuuuuccccuuucaacugugccuagaacaucugga gaacaucccagggaccagugagagcucugcuuuucguuuccucuucaaccucagcagcaucccagaaaaugaggugaucucc ucggcagagcuccggcucuuucgggagcagguggaccagggcccugacugggaacagggcuuccaccguauaaacauuuau gagguuaugaagcccccagcagaaaugguuccuggacaccucaucacacgacuacuggacaccagacuaguccaucacaaugu 10 gacacggugggaaacuuucgaugugagcccugcaguccuucgcuggacccgggaaaagcaacccaauuaugggcuggccauu gaggugacucaccuccaccagacacggacccaccagggccagcaugucagaaucagccgaucguuaccucaagggaguggaga uugggcccaacuccgcccccuccuggucacuuuuggccaugauggccggggccauaccuugacccgcaggagggccaaacgu agucccaagcaucacccacagcgguccaggaagaagaauaagaacugccgucgccauucacuauacguggacuucagugacgu gggcuggaaugauuggauuguggccccacccggcuaccaggccuucuacugccauggggacugucccuuuccacuggcuga 15 ucaccucaacucaaccaaccaugccauugugcagacccuagucaacucuguuaauucuaguaucccuaaggccuguuguguc cccacugaacugagugccauuuccauguuguaccuggaugaguaugacaaggugguguugaaaaauuaucaggagauggug guagagggguguggaugccgcugagaucagacaguccggagggcggacacacacacacacacacacacacacacacacacaca cacacacacguucccauucaaccaccuacacauaccacacaaacugcuucccuauagcuggacuuuuaucuuaaaaaaaaaaaa aagaaagaaagaaagaaagaaagaaaaaaaaugaaagacagaaaagaaaaaaaaaacccuaaacaacucaccuugaccuuauuu 20 augacuuuacgugcaaauguuuugaccauauugaucauauuuugacaaauauauuuauaacuacauauuaaaagaaaauaaa augag ILlr2/Inter- 11 gaaucccacuuacaugcgagcaucucuauauacauccucaaucuauc 261 leukin 1 cccucgaauccacggacuuaucagucaaucaauacuacagucaaagaa receptor, type uuuuuuucuacguuauccuggagcauugcgcuggcaccucuuuuuc II uaaucaucuugguuguggggccaauauggaugcgcagacgguguaa acgcagggcuggaaagacauauggacugaccaagcuacggacugaca AV223216 accaggacuucccuuccagcccaaacuaaauaaaggaaaugaa X59769 Wnt3a/wing- 4 Sequence below. 262 less-related MMTV integration site 3A X56842 gaauucaugucuuacggucaaggcagagggcccagcgccacugcagccgcgccaccucccagggccgggccagcccaggcgu ccgcgcucucgggguggacuccccccgcugcgcgcucaagccggcgauggcuccucucggauaccucuuagugcucugcagc cugaagcaggcucugggcagcuacccgaucuggugguccuuggcugugggaccccaguacuccucucugagcacucagccca 25 uucucugugccagcaucccaggccugguaccgaagcagcugcgcuucugcaggaacuacguggagaucaugcccagcguggc ugagggugucaaagcgggcauccaggagugccagcaccaguuccgaggccggcguuggaacugcaccaccgucagcaacagc cuggccaucuuuggcccuguucuggacaaagccacccgggagucagccuuuguccaugccaucgccuccgcuggaguagcuu ucgcagugacacgcuccugugcagagggaucagcugcuaucugugggugcagcagccgccuccagggcuccccaggcgaggg cuggaaguggggcggcuguagugaggacauugaauuuggaggaauggucucucgggaguuugccgaugccagggagaaccg -184 gccggaugcccgcucugccaugaaccgucacaacaaugaggcugggcgccaggccaucgccagucacaugcaccucaagugca aaugccacgggcuaucuggcagcugugaagugaagaccugcugguggucgcagccggacuuccgcaccaucggggauuucc ucaaggacaaguaugacagugccucggagauggugguagagaaacaccgagagucucguggcuggguggagacccugaggc cacguuacacguacuucaaggugccgacagaacgcgaccuggucuacuacgaggccucacccaacuucugcgaaccuaacccc 5 gaaaccggcuccuucgggacgcgugaccgcaccugcaaugugagcucgcauggcauagaugggugcgaccuguugugcugc gggcgcgggcauaacgcgcgcacugagcgacggagggagaaaugccacuguguuuuccauuggugcugcuacgucagcugc caggagugcacacgugucuaugacgugcacaccugcaaguaggagagcuccuaacacgggagcaggguucauuccgaggggc aagguuccuaccugggggcgggguuccuacuuggaggggucucuuacuuggggacucgguucuuacuugagggcggagau ccuaccugugagggucucauaccuaaggacccgguuucugccuucagccugggcuccuauuugggaucuggguuccuuuuu 10 aggggagaagcuccugucugggauacggguuucugcccgaggguggggcuccacuuggggauggaauuccaauuugggccg gaaguccuaccucaauggcuuggacuccucucuugacccgacagggcucaaauggagacagguaagcuacucccucaacuag gugggguucgugcggaugggugggaggggagagauuagggucccuccucccagaggcacugcucuaucuagauacaugaga gggugcuucagggugggcccuauuugggcuugaggaucccgugggggcggggcuucaccccgacuggguggaacuuuugg agacccccuuccacuggggcaaggcuucacugaagacucaugggauggagcuccacggaaggaggaguuccugagcgagccu 15 gggcucugagcaggccauccagcucccaucuggccccuuuccaguccugguguaagguucaaccugcaagccucaucugcgc agagcaggaucuccuggcagaaugaggcauggagaagaacucaggggugauaccaagaccuaacaaaccccgugccugggua ccucuuuuaaagcucugcaccccuucuucaagggcuuuccuagucuccuuggcagagcuuuccugaggaagauuugcaguc ccccagaguucaagugaacacccauagaacagaacagacucuauccugaguagagaggguucucuaggaaucucuaugggga cugcuaggaaggauccugggcaugacagccucguaugauagccugcauccgcucugacacuuaauacucagaucucccggga 20 aacccagcucauccgguccgugauguccaugccccaaaugccucagagauguugccucacuuugaguuguaugaacuucgga gacauggggacacagucaagccgcagagccaggguuguuucaggacccaucugauuccccagagccugcuguugaggcaaug gucaccagauccguuggccaccacccugucccgagcuucucuagugucugucuggccuggaagugaggugcuacauacagcc caucugccacaagagcuuccugauugguaccacugugaaccgucccucccccuccagacaggggaggggauguggccauaca ggagugugcccggagagcgcggaaagaggaagagaggcugcacacgcguggugacugacugucuucugccuggaacuuugc 25 guucgcgcuuguaacuuuauuuucaaugcugcuauauccacccaccacuggauuuagacaaaagugauuuucuuuuuuuuu uuuucuuuucuuucuaugaaagaaauuauuuuaguuuauaguauguuuguuucaaauaauggggaaaguaaaaagagagaa aaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa 1112rb2/ 3 Sequence below. 263 Interleukin 12 receptor, beta 2 U64199 cgcaccggagguccacacugccgcguggacuccagcgauggcgcugcgcuaggcuagcgggugccaggaucccucucugcgu ccugugcgcgggaagagcucuggagaaccagaguugcauucuggaguugaagacucauggcacagacuguuagagaaugcu 30 cauuggcacuucuuuuuuuguucauguggcugcugauuaaagcaaauauagaugugugcaagcuuggcacugugaccgucc agccugccccugugauuccucuugggucagcugccaauauuuccugcuccuugaaucccaagcaaggcuguucacauuaucc caguucuaacgaauuaauccucuuaaaguuugucaaugauguccuuguugaaaaucuccauggcaagaaaguccaugaccac acuggucacuccuccacuuuucaagucaccaaccugucccuugguaugaccuuguuugucugcaagcuaaacuguagcaacu cucaaaagaagccaccagucccaguaugugggguggagaucucaguugguguugcuccagagccaccucaaaacauaucaug 35 uguccaggaaggagaaaauggaacuguggccuguuccuggaacucuggaaaaguuacuuaucugaaaaccaauuacacuuua caguuaaguggaccaaacaaucugaccugucagaaacaauguuuuucugacaaucgucagaauugcaaucgccuggaucuug ggaucaaucuaagcccugauuuagcugaauccagguucauaguccguguuacugccaucaacgaucuuggaaauucuucuu cacuuccgcauacguucacguucuuggacauagugaucccucuuccuccgugggacaucagaaucaacuuucuaaaugcuuc ugggagcagagguacacugcagugggaagaugaggggcaagugguacucaaucaacucagauaucagccucuuaacagcacg - 185 uccuggaacauggucaaugcuacaaaugccaaaggaaaauaugaccugcgagaucugagaccguuuacagaauaugaauuuc aaaucuccucuaagcuacaucucucuggaggaaguuggaguaauuggagugagucacugagaacacgaacaccagaggaaga gccuguugggauauuagacaucugguacaugaaacaagacaucgacuaugacagacagcagaucucucuuuucuggaagagu cugaauccaucagaggcaagggggaagauccuccacuaucaggugacguuacaagaggugacaaagaaaacaacacugcagaa 5 uacuacaagacacaccuccuggaccagggucaucccccgaacuggggcuuggacggcaucagugucugcagccaacucaaaag gcgcuucugcacccacucacauuaacauaguggaccuauguggcacuggguugcuggcuccucaccaggucucugcaaaguc ggagaacauggacaacauucuagugaccuggcagccuccuaagaaagcugauucugcuguucgggaguacauaguggaaug gagagcucuccaaccagggagcaucacgaaguuucccccacacuggcugcggauccccccggacaacaugucugcucugauu ucagagaacauaaagcccuauaucuguuaugaaaucagggugcaugcacugucagagagccaaggagggugcagcuccaucc 10 ggggugacuccaagcacaaagcaccagugaguggcccucacauuacugccaucacagagaaaaaggaacgccuuuucauuucc uggacccacauuccauucccggagcaaaggggcugcauccuccauuacagaauauacuggaaagaacgagacucgacagcaca accugagcucugcgaaauucaguaccgacgcucucaaaacucacauccaauaagcagccuacagcccagggugacauaugucc uauggaugacagcugugacagcugcuggugaaaguccccaaggaaaugaaagggaauuuuguccacagggcaaagccaacug gaaagcauucgugauaucaagcauuugcaucgcuaucaucacggugggcacguucucaauucguuacuuccggcaaaaggca 15 uuuacucuccugucuacucucaaaccucaaugguauagcagaaccauuccagauccagcaaacagcacuuggguaaagaagu aucccauucuggaggagaagauccagcuaccuacggauaaucuccugauggcauggcccacuccugaagagccugagccccu gaucauccaugaaguccucuaccacaugaucccaguugucagacaaccauauuacuucaaaagaggccaaggauuccaaggcu acucuaccuccaagcaagaugcaauguauauugccaauccacaagcuacaggaacucucacagcugagaccagacaacuagug aaccuauacaaggugcuagaaagcagagacccugacucaaaacuggccaaccugaccagccccuugacagucaccccagugaa 20 cuaccuuccuagccaugaaggcuauuuacccuccaacauagaagaucugucaccacaugaggcugacccaacugauucuuuu gaccuggagcaucaacauauuucucuuuccauuuuugcaucaaguucucuccgcccacucaucuucgguggugagcggcug acucuagaucgguuaaagaugggcuaugacucccucaugaguaaugaggcuugauacuagaaagccaacguaccucauuuua ucugcccaguuccuacuccaaaggucugugacagugaagacaagccagcugucucuggauaaaguuagcuucaccauaggua cuuaagucuuauggauaagguggcaauacaccaacacugauaucauauagaaaggaccccaagauagucaugcuc WntlOa/Wing- 3 Sequence below. 264 less-related MMTV integration site 10a U61969 25 ggcacgaguucacccucugcaugcguuccccuccccccucuccagcaaacacggcgcgccaguccaaagcggacucaguggcc ucggggacgggagcaugccaccuccuguggugacgucacuugggguagaacccuuagacacuacaugggggggggggguac agaacucccgagccaggacagucacucacucuucaggcgguggggcugggccagacaguaccgcccccaccgcgcccgccucg cacacccucggaagcgcaggcucgcagcgcggcgcuggggugggggguugcgccccagaacuucggccuccaguccccagcc cgcugcaccuccuuacccucuagaggcccccucccccuuacccucuagaggcaccaggaguugucgcaaggggcccuuggga 30 aauucccuggaccccugugccaggaggugcccgguucgcccgcuccccauccacccccccgagggcggugcccgggggcgcu gccccauggagcggggaggcgggcgccgucugcugcgggagcugugaccugaguaggagcugugugucgcagccgccccac cccugccgaucaugcgccggcgacccugguucgccagucccacugggcugugagccccccacuccuggccugucacggcccg cgcgccaugggcagcgcccacccucgccccuggcugcggcucccacaagggccccagccgcggccugaguucugggcgcucc uguucuuccuacugcugcuggcugccgcugugcccaggucagcacccaacgacauccugggccuccgccuacccccagagcc 35 cgugcucaacgccaacacagugugccugacauugcccggccugagccggcggcagauggaggugugugugcgucacccugac guggccgccucugcuauccagggcauccagaucgccauccaugagugccagcaucaguuccgggaccagcgcuggaacugcu ccagccuggagacucggaacaaaguccccuacgagagccccaucuucagccgagguuuucgagagagugcuuucgccuacgc - 186 cauagcagcugccgggguggugcacgcaguguccaacgcgugcgcucuggguaaacugaaggcuugcgguugcgacgccuc cagacguggggacgaagaagcuuuccgucggaagcugcaccgcuugcagcuggacgcgcugcagcgcggaaagggcuugagc cacggggucccugaacacccggccauacuuccugccagcccaggucugcaggacuccugggagugggguggcugcaguccgg augugggcuucggagaacgcuucucuaaggacuuucuggacucccgagagccucacagagacauccaugcucgaaugagacu 5 ccacaacaaccgugugggccggcaggcggugauggagaacaugcggcguaagugcaaaugccacggcaccucaggcagcugc cagcucaagaccugcuggcaggugacgccugaguuccgcacaguaggggcgcugcugcgcaaccgcuuccaccgcgccacgc ucauccggccgcacaaccgcaacgguggccagcuggagcccggccccgcgggagcacccucgccagcaccgggcacuccaggg cugcgccgcagggccagccacuccgaccuggucuacuuugagaaaucucccgacuucugugagcgcgagccgcgccuggacu cggcaggcacugugggccgccugugcaauaagagcagcacgggucccgauggcugcggcagcaugugcuguggccgcggcc 10 acaacauucugcgccagacgcgcagcgagcgcugccacugccgguuccacuggugcugcuucguggucugcgaagaaugccg caucaccgagugggucagcgucugcaagugagcagacccaagcuccucugggucucaagaaugguuguccucuuggugccu ggcuucugccgcuagcggaucugagccaggcagcaagcagcagccuuggcuccugagagaggugguuggcucuuacagcccc gagggucuacaaucaccagacaguccagaucugauugacauuccuccgcucaccucuguagguuccccucuuucuguuccua gcucagacagcugggggugauaguggagacuguuccacacccuaggacaggucaccaaagcagcccagccuggcaugccuac 15 cuccugucaucucuucuucccuuccccaggagugauaggcaaugcacugaagcugaugggcaccggggaagaaaacuaaaag gcagaaauggccgucaucgggcugaagugacucuaagggcuccagaccucugcuccugucuuucacuuaacagauauuuau uuuugcgcucucuuugagacacucucuggggaaaaagaagcuccggagucuacaggcugauuaagggacauggacaauaaac caguaaacacacaaaaaaaaaaaaaaaaaa Ifngr2/Inter- 3 Sequence below. 265 feron-gamma receptor precursor M28233 gaauuccgggccgcuugcacuuggcgacuagucugcggcggacgugacgccaaggccacgggcagcgcggguccccugucag 20 aggugucccucgcgcaggaaugggcccgcaggcggcagcuggcaggaugauucugcuggugguccugaugcugucugcgaa ggucgggaguggagcuuugacgagcaccgaggauccugagccucccucggugccuguaccgacgaauguucuaauuaagu uuauaacuugaacccugucguaugcugggaauaccagaacaugucacagacuccuauuuuuacuguacagguaaaggugua uucggguuccuggacugauuccugcaccaacauuucugaucauuguuguaauaucuaugaacaaauuauguauccugaugu aucugccugggccagaguuaaagcuaagguuggacaaaaagaaucugacuaugcacggucaaaagaguuccuuaugugccua 25 aagggaaaggucgggcccccuggccuggagaucaggaggaagaaggaagaacagcucuccguccucguauuucacccugaag ucguugugaauggagagagccagggaaccauguuuggugacgggagcaccuguuacacauucgacuauacuguguaugugg agcauaaccggaguggggagauccuacauacgaaacauacggucgaaaaagaagaguguaaugagacucugugugaguuaaa caucucaguauccacacuggauuccagauauuguauuucaguagacggaaucucaucuuucuggcaaguuagaacagaaaaa ucgaaagacgucuguaucccuccuuuccaugaugacagaaaggauucaauuuggauucuggugguugcuccucuuaccguc 30 uuuacaguaguuauccugguauuugcguauugguauacuaagaagaauucauucaagagaaaaagcauaauguuaccuaag uccuugcucucugugguaaaaagugccacguuagagacaaaaccugaaucgaaguauucacuugucacaccgcaccagccag cuguccuagagagugagacggugaucugugaagagccccuguccacagugacagcuccagacagccccgaagcagcagaaca ggaagaacuuucaaaagaaacaaaggcucuggaggcuggaggaagcacgucugccaugaccccagacagcccuccaacuccga cacaaagacgcagcuuuucccuguuaaguaguaaccagucaggcccuuguagccucaccgccuaucacucccgaaacggcuc 35 ugacaguggccucgugggaucgggcagcuccauaucggacuuggaaucucucccaaacaacaacucagaaacaaagauggca gagcacgacccuccacccgugagaaaggcccccauggccuccgguuaugacaaaccgcacauguugguggacgugcuugugg auguuggggggaaggagucucucaugggguauagacucacaggagaggcccaggagcuguccuaaggucucccgaggccug cuggugguaaagaaacugaccuuuuaggcaguuuuucugcauugauuucaugaaagaagcuauacauuagcuaauacuaac - 187 cacauagaauaucagacuuagauacgugaauaaggauccugugggcacugcuggguccacucugcaaaugccaagacuauca aaggaacguauugucgcuucuggcuccuucccaggugggcuagcaucugugaguuugccucggcuagccuugcuuccuaca gccgccacugcuccuccacccugaucaucucacaggacaggguggaccggguuuuuuuuuuuuuuucacacaccuuuguau auguaaguucauguauauaauauguuuacauguuucacuuugaacugaaagcuacucaaagccagccguaagucuauggua 5 gaaugugauggaacauguugguggaagcuuguacaauagaacacauuggugggagcuuguacauacuuuuuuauggagcau uacuuacgauuuuuuaaguaaaauguuuugaaaccaaaaaaaaaaaaaggaauuc Fgfbpl/ 3 augagacuccacagccucauccugcucuccuuccuucuccuggcuac 266 Fibroblast ucaggcguucucagaaaaggucagaaagagagccaagaacgcaccaca growth factor cagcacagcggaggaggggguagaggguucagcucccucguuaggga binding protein aggcccagaauaagcagagaagcaggacaucuaaaucucugacgcaug 1 gcaaguuugucaccaaagaccaagccacaugcagaugggcugugacu AF065441 gaggaggagcagggcaucagccugaagguccagugcacacaagccga ucaggaguuuucuuguguuuuugcuggugacccaacugacugccuu aaacacgacaaagaccagaucuacuggaaacagguugcccgcacgcug cgcaaacagaaaaauaucugcaggaacgccaagagugucuugaagacc agagugugcagaaagagauuuccagagucuaaccucaagcuggugaa ccccaacgcacguggaaacacgaagcccaggaaggagaaagcagaggu cuccgcaagggagcacaacaagguccaagaagcugucuccacggagcc aaacagggucaaagaagacaucacacucaauccagcugcgacccagac cauggccauuagagauccagagugucuagaggauccagaugugcuca accagaggaagaccgcccuggaguucuguggggaaucuuggagcucc auuugcacauucuuccucaacauguuacaggcgacaucaugcuaa Transcription Factors and Related Genes Klf5/Kruppel- 5 aauucgucgacaugcgccguuccagugcauggugugccaacgcagcu 267 like factor 5 ucucccgcuccgaccaccucgcgcugcacaugaagcgccaccagaacu gagcgagcgagcgcugccccacccgccugacgccuugcaguccgcuc AA611766 ugccauccuuuaaaccgcagaccuaacuucauaaaaaga Gata3/GATA 4 Sequence below. 268 binding protein 3 X55123 gcuaaacuaucccgcaaagauuuuucuuuccucccuaaacccuccuuuuugcucuccuuuucuauacccuuaacugcaaaca aaccauuaaacgaccccucuccugggccuccgacggcaggaguccgcggaccucccaggccgacagcccucccucuacccgcg agguuccgggccgggcgagagggcgcgagcacagccgaggacauggaggugacugcggaccagccgcgcugggugagccacc 10 aucaccccgcgguccucaacggucagcacccagacacgcaccacccgggccucggccauucguacauggaagcucaguauccg cugacggaagagguggacguacuuuuuaacaucgauggucaaggcaaccacgucccguccuacuacggaaacuccgucaggg cuacggugcagagguauccuccgacccaccacgggagccagguaugccgcccgccucugcugcacggaucucugcccuggcu ggauggcggcaaagcccugagcagccaccacaccgccucgcccuggaaccucagccccuucuccaagacguccauccaccacg gcucuccggggccucuguccguuuacccuccggcuucauccucuucucuggcggccggccacuccaguccucaucucuucac 15 cuucccgcccaccccgccgaaagacgucuccccagacccgucgcuguccaccccgggauccgccgggucggccaggcaagaug agaaagagugccucaaguaucaggugcagcugccagauagcaugaagcuggagacgucucacucucgaggcagcaugaccac ccuggguggggccucauccucagcccaccaccccauuaccaccuauccgcccuaugugcccgaguacagcucuggacucuuc - 188 ccacccagcagccugcugggaggauccccuaccggguucggauguaagucgaggcccaaggcacgauccagcacagaaggca gggagugugugaacugcggggcaaccucuaccccacuguggcggcgagaugguaccgggcacuaccuuugcaaugccugcg gacucuaccauaaaaugaaugggcagaaccggccccuuaucaagcccaagcgaaggcugucggcagcaaggagagcagggaca uccugcgcgaacugucagaccaccaccaccacccucuggaggaggaacgcuaauggggacccggucugcaaugccugugggc 5 uguacuacaagcuucauaauauuaacagaccccugacuaugaagaaagaaggcauccagacccgaaaccggaagaugucuagc aaaucgaaaaagugcaaaaaggugcaugacgcgcuggaggacuuccccaagagcagcuccuucaacccggccgcucucuccag acacaugucaucccugagccacaucucucccuucagccacuccagccacaugcugaccacaccgacgcccaugcauccgcccu ccggccucuccuucggaccucaccacccuuccagcauggucaccgccauggguuagagaggcagagcccugcuccacaugcg ugaggagucuccaagugugcgaagaguuccuccgaccccuucuacuugcguuuuucgcaggagcaguaucaugaagcccgaa 10 agcgacagaucuguguuuuugaaggcagaaagcaaaauguuugcuucuuuuuucaaaggagcucgagguggugucugcauu ccaaccacugaauccggaucccauuugugaauaagccauucagacucauauucccuauuuaacagggucucuagugcuguga aaaaaauauugcugaacauugcauauaacuuauauuguaagaaauacuguacauuugaggaagacuuuauuguaccuggau agcuguaagaaaggcaugaaggacgccaagaguuuuaaggaauauaggggnnuuaaaguauggagauacagaagaaaccacu aagucugauguccaaaugggcacacugucaguuuuguuucccuucaguuguuugaugcauuuaaaaaaaaaaaaaagaaaga 15 a Stimulated by 3 Sequence below. 269 retinoic acid 14, basic-helix loop-helix protein Y07836 caaccaccuccuaccugccugcccaaagcuccagggcuggagcacggagaccugucagggauggauuuugcccacauguacc aaguguacaaguccaggcggggaauaaaacggagcgaagacagcaaggaaacuuacaaacugccgcaccggcugauugagaaa aagagacgugaccggauuaacgagugcauugcccagcugaaggaucuccuacccgaacaucucaaacuuacuacuuuggguc acuuggaaaaagcagugguucuggagcuuacguugaagcacgugaaagcauugacaaaucuaauugaucagcagcagcagaa 20 aaucauugcccugcagagcgguuuacaagcuggugauuugucgggaagaaaucucgaggcagggcaagaaauguucugcuc agguuuccagacuugugcccgugagguacuucaguaccuggcgaagcaugagaacacucgggaccugaaaucuucccagcu gucacucaucuccaucguguggucucggagcugcugcaggguggugcuuccaggaaaccauuggacucggcucccaaagcc gucgacuugaaagagaagcccagcuuccuagccaagggaucagaaggcccagggaaaaacugugugccagucauccagcgga cuuuugcucccucggguggggagcagagcggcagugacacggacacagacaguggcuauggaggugaauuggagaaagggg 25 acuugcgcagugaacagccguacuucaaaagcgaccauggacgcagguucgccgugggagaacgugucagcacaauuaagca agaauccgaagagccccccaccacaaagagccgaaugcagcucucagaagaggaaggccacuucgcgggcagugaucugaugg guuccccauuucuugggccacacccacaucagccuccuuuuugccuucccuucuaucucaucccaccaucggccacugccua ccugccuaugcuggagaaaugcugguaccccaccucugugccaguguuauacccaggccucaacaccucagcugcagcccuc uccagcuucaugaacccagacaagauaccgacucccuugcuucugccccagagacucccuucuccuuuggcacauucguccc 30 uugacucuucggccuugcuccaggcuuugaagcagaucccuccuuuaaacuuagaaaccaaagacuaaacucuggagggauc uccugcugccuugcuuucuuuccucccuaauuccaaaaaccacgaagguuucccugagugcagagagaucagcccacccugc agacccacagagaagauucagagugugugugagagugagugagugugcgugcgugcgugcuuguauguauguuuguauau guaggacaauaaguuccuucugacacaagggagacacgagaaggauagccugacaucagaugacagacuggaggacuguagc acaucucugggcguuucccuacccagagaagagcc Cell Cycle Related - 189 - Mki67/antigen 4 Sequence below. 270 identified by monoclonal antibody Ki67 X82786 agucaccgacguuguauaacgacggccagugaauuguaauacgacucacuauagggcgaauuggguaccggccccccccucg aggucgacgguaucgauaagcuugauaucgaauucucgnccgcgugcgggucuggucggggcggagcgaaggccgcgggug gccguggucgguccuccgcggcuaaggagccgagggcuccgacgcgggcugcgcccggugagcggcggccagagcuaacuu gcgcugacuggaccagcugaggagcggcccggcggggcgacugcgagcuucaccgagaggcuucuccgcccugguccgcagu 5 cccgacggccgggcggaccauggcguccucggcucaccuggucaccaucaagcggagcggcgaugacggcgcacacuucccg cugagccucagcuccugccuguuuggaaggaguauugaaugugacauucguauccagcugccuguagugucucaaagacau ugcccaauuguaguccaagagcaagaggcgauauuauauaauuucaguucuaccaauccaacucaaguaaacgggguuacua uagaugagccugugaggcugagacauggagacauaauaaccaucauugaccgcuccuuuagguaugaagauggaaaucauga ggauggaagcaaaccaacagaauuuccaggaaagucccuuggaaaggaaccaucaaggcgagccucaagagauagcuucugu 10 gcugacccugauggggaaggucaagauaccaaagcuucaaaaaugacugcuucaagaagaucuuuuguguaugccaagggcc uuucugcagauagcccugccucagauggcucaaagaacaguguuagccaagacucaucagggcauguagaacagcacacugg cagaaacauaguagagcccacuucugggggaucucuuuuaagaaguccaggucuacagggagcaguuacagggaaccgaagu cuucuuccuacacagagccuuagcaauagcaacgaaaaggaaucucccuuugagaaacuuuaucaaucaaugaaggaagagu uggauguaaaaucccagaaaucuuguaggaaaucagaaccccaaccugaccgugcagcagaggaaucgcgggagacacagcua 15 uuggugucaggcagggcaagagcaaagucuaguggaagcaccccuguuacugcagccucuucacccaaaguaggaaagaucu ggacugagagauggcgcgguggaauggugccuguccagacuuccacagagacagcuaaaaugaagaccccugugcggcauuc acagcaacuuaaggaugaagacucucguguuacuggcagacgacauucugugaaucuggaugaagguggaagugcccaggca guccauaaaacagucacuccugggaaacuggcgacuagaaaccaaacuccgguggaggcuggggauguuggcagccccgcug auacaccagaacauuccucuuccccccagagaaguauuccugcaaagguagaggcuccaucugcagagacacaaaaucggcuc 20 ucuuuaacucagcgccuuguuccaggugaaaagaaaacucccaaggguuccuucagcaagccugagaaacuggccacagccg ccgaacagacuugcucuggccuaccuggucuuaguuccguugauaucagcaacuuuggugauuccauuaacaagagugagg gaaugccuaugaagagaagacguguauccuuugguggacaucuaagaccugaauuauuugaugaaaacuugccuccuaauac accacugaaaagaggagaaacgccaaccaagaggaagucucuuggcacucacagcccagcuguccucaagacaaucaucaagg aacggccccagucuccagggaaacaagagucuccugggauaacgccaccgaggacaaaugaucaaagacgcagaucaggcagg 25 acuuccaguggaagcaauuucuuaugugagacagacauucccaagaaagcaggcaggaagagcgguaaccugccugcgaaga gagcauccaucagccggagucagcauggcauucuacagaugauuugcuccaaaaggcgaaguggagcuucugaagccaacuu gauuguugcaaaaucaugggcugauguuguaaaacuuggcgugaaacaaacacaaacgaaaguugcgaaacaugucccucca aagcagacgagcaagagacaaagaagacccagcacuccaaagaaacccacaagcaaucuucacaaucaauuuacuacaggccau gcaaacucucccuguaccauuguaguagguagagcgcagauugaaaaaguaagugugccugcccgacccuacaaaaugcuga 30 auaacuugaugcuaaaccgaaaaguggacuucagugaagaucugucaggacuaacugaaauguucaagacuccagugaagga gaagcagcagcagaugagugauacaggcuccguacuuuccaauucagcgaauuugucugaaagacaauugcaaguaacuaau ucaggagacauaccugagcccaucaccacagagauuuugggagaaaaagugcuauccaguacucggaaugcagcaaagcagca gucugauagauauucugcaaguccuaccuuaagacggcggagcaucaaacaugaaaacacagugcaaacuccuaagaauguc cauaacauuacugaccuugagaagaagacuccggucucugagacagagccccugaagacugcaucgagugugagcaaguuaa 35 gaagaucuagagagcucagacauacccuuguggaaacuaugaaugaaaaaacagaagcaguccuugcugagaacaccacagca agacauuuaagggggacauuucgagaacaaaaaguagaucaacaggugcaggacaaugaaaacgcuccucaaagaugcaagga aaguggugaauuaagugaagguucagaaaagacaucagcuaggagaucaagugccaggaagcagaagccgacaaaagacuua cuaggaagucagauggucacccaaacagcagacuaugcugaggaacuacuuagucaaggacaaggaaccauacaaaaccuaga - 190ggaauccaugcacaugcaaaacacaucaauaagugaggaucaaggaauuacagaaaagaaagugaacauaauaguauaugcaa ccaaagagaagcacucgccaaagaccccuggcaaaaaggcacaaccucuagaagggccagcuggucucaaggaacacuuugaa acaccaaaccccaaagauaaaccuauaacggaagacagaacuagaguccuuugcaaaucaccacaagucacaacagagaauauc acaacaaacacaaagccacagacuagcacaucugggaagaaaguagacaugaaggaagaaagcucugccuugacaaaacguau 5 acauaugccaggggaauccaggcauaaucccaaaauuuuaaaacuugagugugaggauaucaaagcuuugaagcaaucugaa aaugaaaugcugaccucaacaguaaauggaagcaagaggacuuuaggaaaaucuaaaaaaaaggcucagccccuggaagaccu gacuuguuuccaggaacucuuuauaucaccaguuccuacuaacauaaucaaaaaaauucccagcaaaucuccacacacacaac cagucagaaccccagcgagcacaaagagacucuccaagacaggucucaguaaaguggaugugagacaagaaccuucaacacuu gggaaaagaacgaagucaccaggcagagccccaggcacaccagcaccagugcaggaagaaaaugacugcacagccuacaugga 10 aacuccaaagcagaaacuggagucuauagaaaauuuaacagggcuuaggaaacaguccagaacaccuaaagacaucacugguu uccaggauaguuuccaaauaccagaucaugcuaauggcccauuagugguugucaaaaccaaaaaaauguucuuuaauucucc acaaccagaaagugccauaacccgaaagagcagagagagacagucuagggcaaguauaaguaaaauagauguuaaagaagaac uuuuagaaucagaggaacaccuacaauuaggagaagguguagacacauuucagguauccaccaacaaagucauuagaucauc uaggaaaccugcaaagcguaaacuggauucaacagcugguaugccuaacagcaagaggaugcgcuguucuucaaaggauaac 15 acaccaugccuagaagaccugaauggcuuccaagagcucuuccaaaugccaggcuaugcuaaugacucuuugaccacuggaa ucucaacaaugcuugcuagaucaccacaauuaggaccaguuagaacccaaaucaacaaaaagagucugcccaagaucaucuug agaaaaauggaugugacagaagaaauuucaggucucuggaagcagucacugggcagaguccacaccacacaagagcaggagg auaaugcaaucaaagcaauuauggagauuccaaaggaaacacugcagacugcagcagauggaacuaggcuuaccagacagcca caaacaccuaaggaaaaaguucaaccgcuggaagaucacagugucuuccaagaacucuuccaaacaucacgcuacuguucuga 20 uccauuaauugguaacaaacaaacaagaauguccuugagaucuccacaaccaggauuuguuagaacuccacgaaccucaaaga gacuggcuaagacaaguguugggaauauugcugugagagaaaagaucucuccagugagucugccacagugugcuacagggg agguuguacacauacccauagggccagaagaugacacagagaacaaaggugugaaggaauccacaccucagacacuggacuca ucagcaagucgaacugucagcaagaggcagcaaggggcacaugaggaaaggccucaguucucaggagacuuauuucaucccc aagagcucuuucaaacaccagccaguggcaaagacccaguaacuguugaugaaacuacaaaaauagcucugcagucuccacaa 25 ccaggacauaucauaaacccagcaagcaugaagagacaguccaacaugagucucaggaaagacaugagagaauuuuccauacu ugaaaaacaaacacagucacgaggcagagacgcaggcacaccagcaccaaugcaggaagaaaauggcaccacagccauuaugga aacaccaaagcagaaacuggauuucauaggaaauucaacaggacauaagaggaggccucggacacccaaaaacagggcucagc cccuagaagaccuggauggcuuccaagaacucuuucaaacaccagcuggugccagugacccugugaguguugaagaaagugc aaagauaucuuuggcaucuucacaagcagaaccagucagaaccccagcaaguacaaagagacgcuccaagacaggucucagua 30 aaguggaugugagacaagaaccuucaacacuugggaaaagaaugaagucacuaggcagagccccaggcacaccagcaccagug caggaagaaaaugacagcacagccuucauggaaacuccaaagcagaaacuggauuucacaggaaauucaucaggacauaagag gaggccacagacaccuaagaucagggcucagccccuagaagaccuggauggcuuccaagaacucuuccaaacaccagcuggug ccaaugacucagugacuguugaggaaaguguaaagaugucuuuggaaucuucacaagcagaaccagucaaaaccccggcaag cacaaagagacucuccaagacaggucucaguaagguggaugugagagaagacccuucaauacuugagaaaaaaacaaagucac 35 caggcacaccagcaccagugcaggaagaaaaugacugcacagccuucauggaaacuccaaagcagaaacuggauuucacagga aauucaucaggacauaagaggaggccacggacaccuaagaucagagcucagccccuagaagaccuggauggcuuccaagaacu cuuccaaacaccagcuggugcuagugacucagugacuguugaggaaagugcaaagaugucuuuggaaucuucacaagcaaaa ccagucaaaaccccggcaagcacaaagagacucuccaagacaggucucaguaagguggaugugagagaagacccuucaacacu ugggaaaaaaacaaagucaccaggcagagccccaggcacaccagcaccagugcaggaagaaaaugacagcacagccuucaugg 4 0 aaacuccaaagcagaaacuggauuuugcagagaauucaucagggaguaagagaaggucacgaacaucuaagaacaggucuca gccccuagaagaccuggauggcuuccaagaacucuuccaaacaccagcuggugccaguaacccugugaguguugaagaaagu 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gauaaguuccagugugguuuucaccuccaguguaaagaugaacuguaaauacuacugcuacugccugaguuuaaggaagga agcuuugagcuuuccuggucauacucucuucagacgccaauggaggucaugaggaagaucaccagggaucucagcgcaauua caguuuaggggugagcaggcagaaauguggcccucuguccuauccaauaaagcucugaaauucgcugccaaaa Cks2/CDC28 4 gacguagagccccuugcgcccgguuuccugaucccgcuuacuc 271 protein kinase cucugcgcgccggcaggauggcccacaagcagaucuacuacuca regulatory gacaaguacuucgaugagcacuacgaguaccggcaugucaugu subunit 2, sim uacccagagaacucucuaaacaaguacccaaaacucaucugaug to cdk uccgaagaggaguggaggagacuugguguccaacagagucuag regulatory gauggguucauuacaugauucaugagccagaaccgcauauucu subunit 2 ucucuuuagacgaccucuuccaaaagaacaacaaaaaugaagug cagcugggaucaucuaaucuuuuucaaauuuaauguauaugu AA681998 guauauaagguaguauucagugaauacuugaaaaguguacaaa ccuuucauccauaccugugcaugcgcuguauucuucacagcaa cagagcucagucaaaugcaacugcaaguagg - 192- Ccng2/ 3 Sequence below. 272 Cyclin G2 U95826 cuacccuagacaaucacggcuuagccggcgcgcggagucgaucgucucggucgcuagagcuguccugagcucgaacgguccg acgcccccgccgcgccgguccgugacgccggggccgacacgaugaaggauuugggggccaagcacuuggcagguggcgaagg gguucagcuuuucggauuguugaacuucuaccuggaacaagaacagagauaccaaccucgggaaaaagggcugaucuugaug gaggcuaccccggagaaugauaacacuuuguguucaagacugagaaaugccaaaguggaagauuuaagaaguuuaacuaacu 5 ucuuuggaucuggcacugaaacuuucguucuggcugucaauauuuuggauagauucuuggcccuuaugaaggugaaaccga aacaccuguccugcauuggcgucugcugcuuuuugcuggccgccaggcuggcggaagaagaaggugacguuccccccacgca cgacgugauccgcaucagucaguguaaaugcacagcgucugacauuaaacgcauggagaaaaucaucucagagaaacugcac uaugagcuggaagcuaccacugccuuaaacuuuuugcacuuguaccacgcgauuguauuuugucacacuucagaaaggaag gagauucucagccucgauaaacucgaagcgcagcugaaagcuugcaacugccgaguugucuucuccaaagcaagaccaucug 10 uauuagcucugugccuucucaauuuggaaauagaaacgauaaaauccguggaacugcuggaaauucucuugcuuguuaaaa aacauuugaagcucagcgacacugaauucuuuuacuggagggaacugguuucuaaaugucuagcagaguauucuucgccuc gcugcugcaagccugaucugaagaagcugguauggauuguuucgcgacgcacugcgcagaaccuccacagcagcuacuacag uguuccugagcugcccacuaucccagagggggguugcuuugacggaagugaaagugaggacucuggugaagacaugaguug uggagaggagagucucagcagcuccccacccagcgaucaggagugcaccuucuucuuugacuuccaaguggcucagacacug 15 ugcuuuccaccauagaggaaucugacauuguucugugucagggaauuuauaaguguguguaccuagguuucaaagcaauaa acuuggggguugaauaggguaguuuuccuagguuuccagccccccgucuagucagg Prcl/Protein 3 aacuaccuugggcagguucuauuaacugcaccuaacucagacg 273 regulator of ugaguaggacagaaggaagcugucccgggcgaacugaggucac cytokinesis 1 aaagacuugcuuuugauucaagagagaccuuaaaggcuaguua DNA segment, ugauaguuaaguacaaguuuuaacaucugguagcuaacuuuu Chr 7 uuucucuaccccguaauucuacuaugacugcucuucuagaggu ccugaguucaaaucccagcaaccacaugguggcucacaaccauc AA856349 uauaaugggaucugaugcccucuucuggugugc [000221] Thus, the transcripts identified in this Example, the proteins they encode, and the pathways in which the proteins participate, contribute significantly to induction of epidermal cells to 20 differentiate into HF stem cells. Activation of the transcripts, proteins, and pathways depicted in Table 4 is thus a method for enhancing EDIHN. In addition, inhibition of the transcripts, proteins, and pathways depicted in Table 4 is thus a method for preventing EDIHN and eliminating hair follicles. In addition, inhibition of the transcripts, proteins, and pathways depicted in Table 5 is a method for enhancing EDIHN. In addition, activation of the transcripts, proteins, and pathways 25 depicted in Table 5 is thus a method for enhancing EDIHN. EXAMPLE 10 - 193 - EXPRESSION OF WNT-1 INHIBITORS DURING THE FIRST NINE DAYS AFTER WOUNDING CAUSES PIGMENTATION OF NEW HF MATERIALS AND EXPERIMENTAL METHODS [000222] In this Example, doubly transgenic mice expressing both tetO-Dkkland K5-rtTA were 5 utilized. When these mice are fed chow formulated with 1 g/kg doxycycline (BioServ, Laurel, MD), they express Dkkl, under the control of the K5 promoter, in the basal epidermis. The control mice also received doxycycline, but they were K5-rtTA negative and thus did not express Dkkl. RESULTS [000223] A 1 cm 2 wound was induced on the lower back of the doubly transgenic mice at 21 days or 10 50 days old. Mice were placed on doxycycline-containing chow immediately after wounding to induce Dkkl expression, and then doxycycline was discontinued after completion of the re epithelialization at 9 days after wounding. Dkk1 expression inhibits Wnt activity, which in turn induces follicle pigmentation. At 22 days after wounding, pigmented HF were observed in the excised skin after preparing the epidermal sheet (Figure 23A-B). Control mice lacked pigmented HF 15 (Figure 24). [000224] In other experiments, continued expression of Dkkl after the 9-day period inhibited formation of new HF. [000225] The findings of this Example show that pigmented HF can be produced by suppressing expression of Wntl or by inducing expression of Dkkl during the period ofre-epithelialization, then 20 inducing expression of Wntl. In addition, the findings of this Example show that factors that inhibit neonatal hair follicle formation (e.g. Dkkl) also inhibit EDIHN, thus further supporting the notion that hair follicles formed by EDIHN are similar to normal hair follicles. EXAMPLE 11 INHIBITION OF EDIHN BY EPIDERMAL GROWTH FACTOR INJECTION 25 [000226]21 day-old mice were wounded as described in previous Examples. Starting from day 11 - 194after wounding, a time point corresponding to the point at which the wound had recently re epithelialized, 10 [tL of 1 g/ml EGF was injected into the wound bed. EGF was injected once per day after this point for a total of 5 days. Three days later, the skin was collected, and whole-mount EDIHN assays were performed. EGF prevented HF formation as assessed by gross morphology. In 5 addition, whole mounts of control and treated skin were analyzed with anti-K17 antibody immunostaining. All mice injected with EGF (n=4) exhibited no new HF formation (Figures 25 A B), while control mice (n=2) had many new HF, as expected. (Figures 25 C-D). [000227] In an additional experiment, recombinant EGF (1 microgram (mcg)/microliter (mcl)) was injected at days 11, 13 and 15 after wounding. Skin was collected at 18 days after wounding and 10 stained for K1 7 and alkaline phosphotase. Once again, administration of EGF inhibited EDIHN. [000228] The findings of this Example show that EGF inhibits HF formation. Thus, inhibiting EGF, EGFR, or one of the pathways in which they participate increases EDIHN-induced HF formation. EXAMPLE 12 ENHANCEMENT OF EDIHN BY INHIBITION OF EGF RECEPTOR 15 [000229] To determine the effect of administration of EGF receptor inhibitors on DIHN, the inhibitor AG1478 (150 pM in 10 pL volume) was administered as a single injection 11 days after incisional wounding (1 cm 2 ) to the middle of the wound near the skin surface. EGF receptor inhibitor administration led to generation of more and larger hair follicles compared with control mice that were wounded only (Figure 26A). As shown in Figure 26B, large hair follicles developed in the 20 wounded area in the AG1478-injected mice. Left panel: epidermis stained for K17, with three large hair follicles next to each other. Right panel: dermis stained for AP with large coalescing dermal papilla areas. [000230] The findings of this Example confirm the results of the previous Example, and show that more and larger HF can be generated when EDIHN comprises, or is followed by, administration of 25 EGFR inhibitors, or with compounds with a similar mechanism of action; e.g. Hedgehog protein and androgen antagonists. - 195 - EXAMPLE 13 ENHANCEMENT OF EDIHN BY EXPRESSION OF A B-CATENIN ACTIVATOR [000231] To determine the effect of administration of B-catenin activators on EDIHN, K14-Wnt7 transgenic mice, which overexpress the B-catenin pathway activator, Wnt7, in the epidermis, were 5 subjected to EDIHN, then HF formation was measured 19 days after wounding. In each of 2 separate experiments, with 4 week old and 3 week old mice, the transgenic mice developed significantly larger numbers of HF compared to control, non-transgenic littermate mice (Figure 27 A-C). [000232] Thus, administration of B-catenin activators leads to an increase in EDIHN. The findings of Examples 11-13 show that new HF can be generated by (a) disrupting the epidermis; and (b) 10 administering a factor that promotes a differentiation of an uncommitted epidermal cell into a HF cell. EXAMPLE 14 ENHANCEMENT OF EDIHN BY ADMINISTRATION OF FGF [000233] To determine the effect of fibroblast growth factor (FGF) on EDIHN, recombinant FGF is 15 administered 11 days after incisional wounding, as decribed in Example 11. FGF administration enhances HF formation, showing that new HF can be generated by (a) disrupting the epidermis; and (b) administering FGF, a nucleotide encoding FGF, or a factor that increases signaling by FGF. EXAMPLE 15 ENHANCEMENT OF EDIHN BY ADMINISTRATION OF EDAR 20 [000234] To determine the effect of fibroblast growth factor (FGF) on EDIHN, K14-Eda-Al transgenic mice, which overexpress (ectodysplasin-A1) Eda-Al in the epidermis, are subjected to EDIHN, then HF formation is measured 19 days after wounding as described in Example 13. The transgenic mice develope significantly larger numbers of HF compared to control, non-transgenic littermate mice, showing that new HF can be generated by (a) disrupting the epidermis; and (b) 2 5 administering a factor that enhances signaling by ectodysplasin. - 196- 197 EXAMPLE 16 ENHANCEMENT OF EDIHN BY ADMINISTRATION OF MINOXIDIL [000235] To determine the effect of minoxidil on EDIHN, recombinant FGF is administered 11 days after incisional wounding, as decribed in Example 11. Minoxidil 5 administration enhances HF formation, showing that new HF can be generated by (a) disrupting the epidermis; and (b) administering a minoxidil. EXAMPLE 17 REMOVAL OF HF BY ABRASION AND ADMINISTRATION OF EGF [000236] Hair-bearing regions of the epidermis of mice is abraded, as decribed in Example 10 1, then administering recombinant EGF, as described in Example 1. This method prevents hair re-growth in the abraded areas, showing that hair can be removed by (a) disrupting the epidermal layer; and (b) administering EGF, a nucleotide encoding EGF, or a factor that increases signaling by EGF. [000237] Comprises/comprising and grammatical variations thereof when used in this 15 specification are to be taken to specify the presence of stated features, integers, steps or components or groups thereof, but do not preclude the presence or addition of one or more other features, integers, steps, components or groups thereof.

Claims

1. A method for treating baldness in a human subject comprising wounding an area of the balding scalp of said human subject, wherein the wounding-step comprises disrupting, beyond the stratum comeum, an epidermis or dermis of the area of the balding scalp; and contacting the wounded area of the balding scalp with minoxidil.

2. The method of claim 1, wherein said wounding is performed with a tool that comprises sandpaper, a laser, a Fraxel laser, a CO 2 laser, an excimer laser, a felt wheel, a dermabrasion device, a light-based method, irradiation with visible light, irradiation with infrared light, irradiation with ultraviolet radiation, orthovoltage radiation, x-ray radiation, a surgical tool, a dermal biopsy punch, or is performed with a burn treatment or chemical treatment.

3. The method of claim 2, wherein said dermabrasion device is a micro-dermabrasion device.

4. The method of claim 1, wherein said wounding is dermabrasion.

5. The method of claim 1 or 2, wherein the wounding-step comprises disrupting the epidermis and dermis of the area of the balding scalp.

6. The method of claim 1 or 2, in which only part of the epidermis is removed.

7. The method of any one of the previous claims, wherein the minoxidil is administered as a cream, gel, lotion, emulsion, suspension, oil, non-aqueous solution, aqueous solution, or drop, or by direct injection, or is encapsulated in a liposome.

8. The method of any one of the previous claims, wherein said wounding-step is performed between 3-12 days, 4-12 days, 5-12 days, 4-11 days, 6-11 days, 6-10 days, 6-9 days, 6-8 days, 7-8 days, 5-11 days, 5- 10 days, 7- 10 days, or about 1 week prior to said contacting step.

9. The method of any one of the previous claims, wherein said area of the balding scalp is subjected to depilation or administration of a retinoid prior to said wounding. 199

10. The method of claim 9, wherein said depilation is performed by plucking, waxing, abrasion, laser, electrolysis, or administration of thioglycolic acid on said area of the balding scalp.

11. The method of any one of the previous claims, wherein said wounded area of the balding scalp is not surgically closed, or not contacted with a bandage, dressing, or ointment that facilitates wound healing for a period of time following said wounding-step.

12. The method of claim 11, wherein said period of time is within about 1 day, about 2 days, about 3 days, about 4 days, about 5 days, about 7 days, about 10 days, about 11 days, about 14 days, about 17 days, or about 3 weeks.

13. The method of any one of the previous claims, wherein said wounded area of the balding scalp is allowed to heal by secondary intention.

14. The method of any one of the previous claims, wherein said step of contacting the wounded area of the balding scalp with minoxidil is within about 1 day, about 2 days, about 3 days, about 4 days, about 5 days, about 7 days, about 10 days, about 11 days, about 14 days, about 17 days, or about 3 weeks of said wounding-step.

15. The method of any one of the previous claims, wherein the method is performed on a subject with androgenetic alopecia (AGA), scarring alopecia, male pattern baldness, female pattern baldness, discoid lupus erythematosis, or lichen planopilaris.

16. The method of any one of the previous claims, wherein said treatment results in an increase in markers of hair follicle proliferation, hair follicle differentiation or hair follicle embryonic development.

17. The method of any one of the previous claims, wherein said treatment results in an increase in the amount of pigmented hair or an increase in hair follicle size.

18. The method of any one of the previous claims, wherein said treatment results in differentiation of an uncommitted epidermal cell into a hair follicle cell.

19. The method of any one of the previous claims, wherein said treatment results in generation of a hair follicle in the scalp of the subject. 200

20. The method of any one of the previous claims substantially as hereinbefore described. THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA WATERMARK PATENT AND TRADE MARK ATTORNEYS P36288AU01