AU2014233591B2 - Cell line, system and method for optical control of secondary messengers - Google Patents
Cell line, system and method for optical control of secondary messengersInfo
- Publication number
- AU2014233591B2 AU2014233591B2 AU2014233591A AU2014233591A AU2014233591B2 AU 2014233591 B2 AU2014233591 B2 AU 2014233591B2 AU 2014233591 A AU2014233591 A AU 2014233591A AU 2014233591 A AU2014233591 A AU 2014233591A AU 2014233591 B2 AU2014233591 B2 AU 2014233591B2
- Authority
- AU
- Australia
- Prior art keywords
- cell line
- optical control
- secondary messengers
- cell
- expressing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 230000003287 optical effect Effects 0.000 title 1
- 102000018697 Membrane Proteins Human genes 0.000 abstract 2
- 108010052285 Membrane Proteins Proteins 0.000 abstract 2
- YZXBAPSDXZZRGB-DOFZRALJSA-N arachidonic acid Chemical compound CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O YZXBAPSDXZZRGB-DOFZRALJSA-N 0.000 abstract 2
- NCYCYZXNIZJOKI-IOUUIBBYSA-N 11-cis-retinal Chemical compound O=C/C=C(\C)/C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C NCYCYZXNIZJOKI-IOUUIBBYSA-N 0.000 abstract 1
- ZOOGRGPOEVQQDX-UUOKFMHZSA-N 3',5'-cyclic GMP Chemical compound C([C@H]1O2)OP(O)(=O)O[C@H]1[C@@H](O)[C@@H]2N1C(N=C(NC2=O)N)=C2N=C1 ZOOGRGPOEVQQDX-UUOKFMHZSA-N 0.000 abstract 1
- 108060003345 Adrenergic Receptor Proteins 0.000 abstract 1
- 102000017910 Adrenergic receptor Human genes 0.000 abstract 1
- 102100040756 Rhodopsin Human genes 0.000 abstract 1
- 108090000820 Rhodopsin Proteins 0.000 abstract 1
- MMWCIQZXVOZEGG-HOZKJCLWSA-N [(1S,2R,3S,4S,5R,6S)-2,3,5-trihydroxy-4,6-diphosphonooxycyclohexyl] dihydrogen phosphate Chemical compound O[C@H]1[C@@H](O)[C@H](OP(O)(O)=O)[C@@H](OP(O)(O)=O)[C@H](O)[C@H]1OP(O)(O)=O MMWCIQZXVOZEGG-HOZKJCLWSA-N 0.000 abstract 1
- 229940114079 arachidonic acid Drugs 0.000 abstract 1
- 235000021342 arachidonic acid Nutrition 0.000 abstract 1
- 239000002773 nucleotide Substances 0.000 abstract 1
- 125000003729 nucleotide group Chemical group 0.000 abstract 1
Landscapes
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Abstract A method of generating secondary messengers such as cAMP, cGMP, inositol triphosphate and arachidonic acid in a cell, the method comprising modifying a nucleotide sequence for expressing a chimeric light responsive rhodopsin-based membrane protein with one or more heterologous adrenergic receptors alpha 1 and beta2; and expressing the light responsive membrane protein in a cell for producing a secondary messenger in response to light.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2014233591A AU2014233591B2 (en) | 2008-05-29 | 2014-09-25 | Cell line, system and method for optical control of secondary messengers |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US61/057,108 | 2008-05-29 | ||
| AU2009256457A AU2009256457B2 (en) | 2008-05-29 | 2009-05-29 | Cell line, system and method for optical control of secondary messengers |
| AU2014233591A AU2014233591B2 (en) | 2008-05-29 | 2014-09-25 | Cell line, system and method for optical control of secondary messengers |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2009256457A Division AU2009256457B2 (en) | 2008-05-29 | 2009-05-29 | Cell line, system and method for optical control of secondary messengers |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2014233591A1 AU2014233591A1 (en) | 2014-11-06 |
| AU2014233591B2 true AU2014233591B2 (en) | 2016-09-22 |
Family
ID=51845025
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2014233591A Ceased AU2014233591B2 (en) | 2008-05-29 | 2014-09-25 | Cell line, system and method for optical control of secondary messengers |
Country Status (1)
| Country | Link |
|---|---|
| AU (1) | AU2014233591B2 (en) |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003016486A2 (en) * | 2001-08-16 | 2003-02-27 | Sloan Kettering Institute For Cancer Research | Bio-synthetic photostimulators and methods of use |
| US20070261127A1 (en) * | 2005-07-22 | 2007-11-08 | Boyden Edward S | Light-activated cation channel and uses thereof |
-
2014
- 2014-09-25 AU AU2014233591A patent/AU2014233591B2/en not_active Ceased
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003016486A2 (en) * | 2001-08-16 | 2003-02-27 | Sloan Kettering Institute For Cancer Research | Bio-synthetic photostimulators and methods of use |
| US20070261127A1 (en) * | 2005-07-22 | 2007-11-08 | Boyden Edward S | Light-activated cation channel and uses thereof |
Non-Patent Citations (2)
| Title |
|---|
| KIM, J-M. et al. Biochemistry, 2005, Vol. 44, Pages 2284-2292 * |
| MARIN, E.P. et al. J. Biol. Chem. 2000, vol. 275, No. 3 pages 1930-1936. * |
Also Published As
| Publication number | Publication date |
|---|---|
| AU2014233591A1 (en) | 2014-11-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FGA | Letters patent sealed or granted (standard patent) | ||
| MK14 | Patent ceased section 143(a) (annual fees not paid) or expired |