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AU2014253528B2 - Pyrido[2,3-b]pyrazine-8-substituted compounds and their use - Google Patents
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AU2014253528B2 - Pyrido[2,3-b]pyrazine-8-substituted compounds and their use - Google Patents

Pyrido[2,3-b]pyrazine-8-substituted compounds and their use

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Publication number
AU2014253528B2
AU2014253528B2 AU2014253528A AU2014253528A AU2014253528B2 AU 2014253528 B2 AU2014253528 B2 AU 2014253528B2 AU 2014253528 A AU2014253528 A AU 2014253528A AU 2014253528 A AU2014253528 A AU 2014253528A AU 2014253528 B2 AU2014253528 B2 AU 2014253528B2
Authority
AU
Australia
Prior art keywords
raf
compounds
inhibit
activity
cancer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2014253528A
Other versions
AU2014253528A1 (en
Inventor
Richard Marais
Delphine Menard
Dan Niculescu-Duvaz
Ion Niculescu-Duvaz
Arnaud Nourry
Caroline Joy Springer
Bartholomeus Marinus Josephus Marie Suijkerbuijk
Alfonso Zambon
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Institute of Cancer Research Royal Cancer Hospital
Cancer Research Technology Ltd
Original Assignee
Institute of Cancer Research Royal Cancer Hospital
Cancer Research Technology Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from AU2008337286A external-priority patent/AU2008337286B2/en
Application filed by Institute of Cancer Research Royal Cancer Hospital, Cancer Research Technology Ltd filed Critical Institute of Cancer Research Royal Cancer Hospital
Priority to AU2014253528A priority Critical patent/AU2014253528B2/en
Publication of AU2014253528A1 publication Critical patent/AU2014253528A1/en
Application granted granted Critical
Publication of AU2014253528B2 publication Critical patent/AU2014253528B2/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

The present invention pertains generally to the field of therapeutic compounds for treating 5 proliferative disorders, cancer, etc., and more specifically to certain pyrido[2,3-b]pyrazin 8-substituted compounds, as described herein, which, inter alia, inhibit RAF (e.g., B-RAF) activity. The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit RAF (e.g., BRAF) activity, to inhibit receptor tyrosine kinase (RTK) activity, 10 to inhibit cell proliferation, and in the treatment of diseases and disorders that are ameliorated by the inhibition of RAF, RTK, etc., proliferative disorders such as cancer (e.g., colorectal cancer, melanoma), etc.
AU2014253528A 2007-12-19 2014-10-23 Pyrido[2,3-b]pyrazine-8-substituted compounds and their use Ceased AU2014253528B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2014253528A AU2014253528B2 (en) 2007-12-19 2014-10-23 Pyrido[2,3-b]pyrazine-8-substituted compounds and their use

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US61/015,019 2007-12-19
AU2008337286A AU2008337286B2 (en) 2007-12-19 2008-12-19 Pyrido[2,3-b]pyrazine-8-substituted compounds and their use
AU2014253528A AU2014253528B2 (en) 2007-12-19 2014-10-23 Pyrido[2,3-b]pyrazine-8-substituted compounds and their use

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
AU2008337286A Division AU2008337286B2 (en) 2007-12-19 2008-12-19 Pyrido[2,3-b]pyrazine-8-substituted compounds and their use

Publications (2)

Publication Number Publication Date
AU2014253528A1 AU2014253528A1 (en) 2014-11-13
AU2014253528B2 true AU2014253528B2 (en) 2016-07-21

Family

ID=51869898

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2014253528A Ceased AU2014253528B2 (en) 2007-12-19 2014-10-23 Pyrido[2,3-b]pyrazine-8-substituted compounds and their use

Country Status (1)

Country Link
AU (1) AU2014253528B2 (en)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006067466A2 (en) * 2004-12-22 2006-06-29 The Wellcome Trust Limited Pyrazines and pyridines and derivatives thereof as therapeutic compounds

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006067466A2 (en) * 2004-12-22 2006-06-29 The Wellcome Trust Limited Pyrazines and pyridines and derivatives thereof as therapeutic compounds

Also Published As

Publication number Publication date
AU2014253528A1 (en) 2014-11-13

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Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired