AU2015201950B2 - Compositions and Processes for Preparing 13-Deoxy-Anthracyclines - Google Patents
Compositions and Processes for Preparing 13-Deoxy-AnthracyclinesInfo
- Publication number
- AU2015201950B2 AU2015201950B2 AU2015201950A AU2015201950A AU2015201950B2 AU 2015201950 B2 AU2015201950 B2 AU 2015201950B2 AU 2015201950 A AU2015201950 A AU 2015201950A AU 2015201950 A AU2015201950 A AU 2015201950A AU 2015201950 B2 AU2015201950 B2 AU 2015201950B2
- Authority
- AU
- Australia
- Prior art keywords
- reaction
- anthracyclines
- deoxy
- precipitates
- compositions
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
13-benzenesulfonylhydrazone anthracyclines useful in producing improved yields in the synthesis 13-deoxyanthreyclines, and an improved method of reducing 13-benzene sulfonylhydrazone anthracyclines to 13-deoxyanthrcyclines wherein the reduction reaction is maintained at temperatures of about 55 "C to 64 'C without stirring or agitation. The reaction is completed with the addition of aqueous bicarbonate which forms the 13-deoxyanthracycline and precipitates. The precipitates are filtered and the precipitate and filtrate are extracted separately with organic solvents. The crude 13-deoxy anthracycline can be converted to 5-imino-13-deoxy anthracycline by reaction with methanolic ammonia. The reaction can also be performed with an acidic pyridinium salt instead of a strong acid so that neutralization of the reaction or extraction of the product is not necessary, thereby facilitating purification. 5244A-AU-D2
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2015201950A AU2015201950B2 (en) | 2004-11-08 | 2015-04-17 | Compositions and Processes for Preparing 13-Deoxy-Anthracyclines |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/982,873 | 2004-11-08 | ||
| AU2012211397A AU2012211397B2 (en) | 2004-11-08 | 2012-08-08 | Compositions and Processes for Preparing 13-Deoxy-Anthracyclines |
| AU2015201950A AU2015201950B2 (en) | 2004-11-08 | 2015-04-17 | Compositions and Processes for Preparing 13-Deoxy-Anthracyclines |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2012211397A Division AU2012211397B2 (en) | 2004-11-08 | 2012-08-08 | Compositions and Processes for Preparing 13-Deoxy-Anthracyclines |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2015201950A1 AU2015201950A1 (en) | 2015-05-07 |
| AU2015201950B2 true AU2015201950B2 (en) | 2016-07-14 |
Family
ID=53016349
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2015201950A Ceased AU2015201950B2 (en) | 2004-11-08 | 2015-04-17 | Compositions and Processes for Preparing 13-Deoxy-Anthracyclines |
Country Status (1)
| Country | Link |
|---|---|
| AU (1) | AU2015201950B2 (en) |
-
2015
- 2015-04-17 AU AU2015201950A patent/AU2015201950B2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| AU2015201950A1 (en) | 2015-05-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FGA | Letters patent sealed or granted (standard patent) | ||
| DA3 | Amendments made section 104 |
Free format text: THE NATURE OF THE AMENDMENT IS: AMEND THE INVENTION TITLE TO READ COMPOSITIONS AND PROCESSES FOR PREPARING 13-DEOXY-ANTHRACYCLINES |
|
| MK14 | Patent ceased section 143(a) (annual fees not paid) or expired |