AU2016200921B2 - Method for better utilising the production potential of transgenic plants - Google Patents

Abstract

METHOD FOR BETTER UTILISING THE PRODUCTION POTENTIAL OF TRANSGENIC PLANTS Abstract The invention relates to a method for better utilising the production potential of transgenic plants. Said plant is treated with combinations of active substances containing an active substance from the group of anthranillic acid amids and at least one other insecticide.

Description

Method for better utilising the production potential of transgenic plants

The invention relates to a method for improving the utilization of the production potential of transgenic plants.

In recent years, there has been a marked increase in the proportion of transgenic plants in agriculture, even if regional differences are still noticeable to date. Thus, for example, the proportion of transgenic maize in the USA has doubled from 26% to 52% since 2001, while transgenic maize has hardly been of any practical importance in Germany. However, in other European countries, for example in Spain, the proportion of transgenic maize is already about 12%.

Transgenic plants are employed mainly to utilize the production potential of respective plant varieties in the most favourable manner, at the lowest possible input of production means. The aim of the genetic modification of the plants is in particular the generation of resistance in the plants to certain pests or harmful organisms or else herbicides and also to abiotic stress (for example drought, heat or elevated salt levels). It is also possible to modify a plant genetically to increase certain quality or product features, such as, for example, the content of selected vitamins or oils, or to improve certain fibre properties.

Herbicide resistance or tolerance can be achieved, for example, by incorporating genes into the useful plant for expressing enzymes to detoxify certain herbicides, so that a relatively unimpeded growth of these plants is possible even in the presence of these herbicides for controlling broadleaved weeds and weed grasses. Examples which may be mentioned are cotton varieties or maize varieties which tolerate the herbicidally active compound glyphosate (Roundup®), (Roundup Ready®, Monsanto) or the herbicides glufosinate or oxynil.

More recently, there has also been the development of useful plants comprising two or more genetic modifications (“stacked transgenic plants” or multiply transgenic crops). Thus, for example, Monsanto has developed multiply transgenic maize varieties which are resistant to the European com borer (Ostrinia nubilalis) and the Western com rootworm (Diabrotica virgifera). Also known are maize and cotton crops which are both resistant to the Western com rootworm and the cotton bollworm and tolerant to the herbicide Roundup®.

It has now been found that the utilization of the production potential of transgenic useful plants can be improved even more by treating the plants with a mixture of an active compound of the formula (I) and an active compound of group II. Here, the term “treatment” includes all measures resulting in a contact between these active compounds and at least one plant part. “Plant parts” are to be understood as meaning all above-ground and below-ground parts and organs of plants, such as shoot, leaf, flower and root, by way of example leaves, needles, stalks, stems, flowers, fruit bodies, fruits and seed, and also roots, tubers and rhizomes. The plant parts also include harvested material and also vegetative and generative propagation material, for example cuttings, tubers, rhizomes, slips and seed.

It is already known that compounds of the formula (I) have insecticidal action (for example from WO 03/015519 and WO 04/067528), and that they can be used in mixtures (for example from WO 05/048711, WO 05/107468, WO 06/007595, WO 06/068669). These documents are expressly incorporated herein by way of reference.

In a first aspect the present invention provides a method for improving the utilization of the production potential of a transgenic plant, the method comprising treating the plant with an effective amount of a mixture of at least one compound of the formula I

where R1 represents chlorine or cyano and at least one compound of group II, wherein group II comprises imidacloprid, thiodicarb, clothianidin, methiocarb, thiacloprid, thiamethoxam, fipronil, tefluthrin, beta-cyfluthrin, abamectin and spinosad.

In a second aspect the present invention provides plant parts of transgenic plants obtained by a method according to the first aspect.

In a third aspect the present invention provides plant parts of transgenic plants treated by a method according to the first aspect.

The mixtures which can be used according to the invention comprise an active compound of the formula (I) as follows:

where R1 represents Cl or cyano and at least one compound of group II, which comprises imidachloprid, thiodicarb, clothianidin, methiocarb, thiacloprid, thiamethoxam, fipronil, tefluthrin, beta-cyfluthrin, abamectin or spinosad.

Preference is given to mixtures comprising the active compound of the formula (1-1)

and at least one compound of group II, which comprises imidachloprid, thiodicarb, clothianidin, methiocarb, thiacloprid, thiamethoxam, fipronil, tefluthrin, beta-cyfluthrin, abamectin or spinosad.

Preference is likewise given to mixtures comprising the active compound of the formula (1-2)

and at least one compound of group II, which comprises imidachloprid, thiodicarb, clothianidin, methiocarb, thiacloprid, thiamethoxam, fipronil, tefluthrin, beta-cyfluthrin, abamectin or spinosad.

Particular preference is given to the mixtures below comprising the active compound of the formula 1-1 and imidacloprid; the active compound of the formula 1-1 and clothianidin; the active compound of the formula 1-2 and imidacloprid; the active compound of the formula 1-2 and clothianidin.

In addition, the active compound combinations may also comprise further fungicidally, acaricidally or insecticidally active co-components.

In general, the mixtures according to the invention comprise an active compound of the formula (I) and an active compound of group (II) in the stated preferred and particularly preferred mixing ratios:

The preferred mixing ratio is from 250:1 to 1:50.

The particularly preferred mixing ratio is from 25:1 to 1:25.

The mixing ratios are based on weight ratios. The ratio is to be understood as active compound of the formula (I): co-component of group (II).

According to the method proposed according to the invention, transgenic plants, in particular useful plants, are treated with the mixtures according to the invention to increase agricultural productivity. For the purpose of the invention, transgenic plants are plants which contain at least one "foreign gene". The term "foreign gene" in this connection means a gene or gene fragment which may originate or be derived from another plant of the same species, from plants of a different species, but also from organisms from the animal kingdom or microorganisms (including viruses) (“foreign gene”) and/or, if appropriate, already has mutations compared to a naturally occurring gene or gene fragment. According to the invention, it is also possible to use synthetic genes or gene fragements, which is also included in the term “foreign gene” here. It is also possible for a transgenic plant to code for two or more foreign genes of different origin.

For the purpose of the invention, the “foreign gene” is further characterized in that it comprises a nucleic acid sequence which has a certain biological or chemical function or activity in the transgenic plant. In general, these genes code for biocatalysts, such as, for example, enzymes or ribozymes, or else they comprise regulatory sequences, such as, for example, promoters or terminators, for controlling the expression of endogenous proteins. However, to this end, they may also code for regulatory proteins, such as, for example, repressors or inductors. Furthermore, the foreign gene may also serve the targeted localization of a gene product of the transgenic plant, coding, for example, for a signal peptide. The foreign gene may also code for inhibitors, such as, for example, antisense RNA.

The person skilled in the art is readily familiar with numerous different methods for producing transgenic plants and methods for the targeted mutagenesis, for gene transformation and cloning, for example from: Willmitzer, 1993, Transgenic plants, in: Biotechnology, A Multivolume Comprehensive Treatise, Rehm et al. (eds.), Vol. 2, 627-659, VCH Weinheim, Germany; McCormick et al., 1986, Plant Cell Reports 5: 81-84; EP-A 0221044; EP-A 0131624, or Sambrook et al., 1989, "Molecular Cloning: A Laboratory Manual", 3rd Ed., Cold Spring Harbor Laboratory

Press, Cold Spring Harbor, NY; Winnacker, 1996, "Gene und Klone" [Genes and Clones], 2nd Ed., VCH Weinheim or Christou, 1996, Trends in Plant Science 1: 423-431. Examples of transit or signal peptides or time- or site-specific promoters are disclosed, for example, in Braun et al., 1992, EMBO J. 11: 3219-3227; Wolter et al., 1988, Proc. Natl. Acad. Sci. USA 85: 846-850; Sonnewald et al., 1991, Plant J. 1: 95-106. A good example of a complex genetic manipulation of a useful plant is the so-called GURT technology (“Genetic Use Restriction Technologies”) which allows the technical control of the propagation of the transgenic plant variety in question. To this end, in general two or three foreign genes are cloned into the useful plant which, in a complex interaction after administration of an external stimulus, trigger a cascade resulting in the death of the embryo which would otherwise develop. To this end, the external stimulus (for example an active compound or another chemical or abiotic stimulus) may interact, for example, with a repressor which then no longer suppresses the expression of a recombinase, so that the recombinase is able to cleave an inhibitor thus allowing expression of a toxin causing the embryo to die. Examples of this type of transgenic plants are disclosed in US 5,723,765 or US 5,808,034.

Accordingly, the person skilled in the art is familiar with processes for generating transgenic plants which, by virtue of the integration of regulatory foreign genes and the overexpression, suppression or inhibition of endogenous genes or gene sequences mediated in this manner, if appropriate, or by virtue of the existence or expression of foreign genes or fragments thereof, have modified properties.

As already discussed above, the method according to the invention allows better utilization of the production potential of transgenic plants. On the one hand, this may, if appropriate, be based on the fact that the application rate of the active compound which can be employed according to the invention can be reduced, for example by lowering the dose employed or else by reducing the number of applications. On the other hand, if appropriate, the yield of the useful plants may be increased quantitatively and/or qualitatively. This is true in particular in the case of a transgenically generated resistance to biotic or abiotic stress.

Depending on the plant species or plant varieties, their location and the growth conditions (soils, climate, vegetation period, nutrients), these synergistic actions may vary and may be multifarious. Thus possible are, for example, reduced application rates and/or a widening of the activity spectrum and/or an increase of the activity of the compounds and compositions used according to the invention, better plant growth, increased tolerance to high or low temperatures, increased tolerance to drought or to water or soil salt content, increased flowering, easier harvesting, accelerated maturation, higher harvest yields, higher quality and/or higher nutrient value of the harvested products, increased storability and/or processibility of the harvested products, which exceed the effects normally to be expected.

These advantages are the result of a synergistic action, achieved according to the invention, between the mixtures according to the invention which can be employed and the respective principle of action of the genetic modification of the transgenic plant. This reduction of production means as a result of the synergism, with simultaneous yield or quality increase, is associated with considerable economical and ecological advantages. A list of examples known to the person skilled in the art of transgenic plants, with the respective affected structure in the plant or the protein expressed by the genetic modification in the plant being mentioned, is compiled in Table 1. Here, the structure in question or the principle expressed is in each case grouped with a certain feature in the sense of a tolerance to a certain stress factor. A similar list (Table 3) compiles - in a slightly different arrangement * likewise examples of principles of action, tolerances induced thereby and possible useful plants. Further examples of transgenic plants suitable for the treatment according to the invention are compiled in Table 4.

In an advantageous embodiment, the mixtures according to the invention are used for treating transgenic plants comprising at least one foreign gene coding for a Bt toxin. A Bt toxin is a protein originating from or derived from the soil bacterium Bacillus thuringiensis which either belongs to the group of the crystal toxins (Cry) or the cytolytic toxins (Cyt). In the bacterium, they are originally formed as protoxins and are only metabolized in alkaline medium - for example in the digestive tract of certain feed insects - to their active form. There, the active toxin then binds to certain hydrocarbon structures at cell surfaces causing pores to be formed which destroy the osmotic potential of the cell, which may effect cell lysis. The result is the death of the insects. Bt toxins are active in particular against certain harmful species from the orders of the Lepidoptera (butterflies), Homoptera, Diptera and Coleoptera (beetles) in all their development stages; i.e. from the egg larva via their juvenile forms to their adult forms.

It has been known for a long time that gene sequences coding for Bt toxins, parts thereof or else peptides or proteins derived from Bt toxins can be cloned with the aid of genetic engineering into agriculturally useful plants to generate transgenic plants having endogenous resistance to pests sensitive to Bt toxins. For the purpose of the invention, the transgenic plants coding for at least one Bt toxin or proteins derived therefrom are defined as “Bt plants”.

The “first generation” of such Bt plants generally only comprise the genes enabling the formation of a certain toxin, thus only providing resistance to one group of pathogens. An example of a commercially available maize variety comprising the gene for forming the CrylAb toxin is “YieldGard®” from Monsanto which is resistant to the European com borer. In contrast, in the Bt cotton variety (Bollgard®), resistance to other pathogens from the family of the Lepidoptera is generated by introduction by cloning of the genes for forming the Cry 1 Ac toxin. Other transgenic crop plants, in turn, express genes for forming Bt toxins with activity against pathogens from the order of the Coleoptera. Examples that may be mentioned are the Bt potato variety “NewLeaf®” (Monsanto) capable of forming the Cry3A toxin, which is thus resistant to the Colorado potato beetle, and the transgenic maize variety “YieldGard®” (Monsanto) which is capable of forming the Cry 3Bbl toxin and is thus protected against various species of the Western com rootworm.

In a “second generation”, the multiply transgenic plants, already described above, expressing or comprising at least two foreign genes were generated.

Preference according to the invention is given to transgenic plants with Bt toxins from the group of the Cry family (see, for example, Crickmore et at., 1998, Microbiol. Mol. Biol. Rev. 62 : 807-812), which are particularly effective against Lepidoptera, Coleoptera and Diptera. Examples of genes coding for the proteins are: cryl Aal, crylAa2, crylAa3, crylAa4, crylAaS, crylAa6, crylAa7, crylAaS, crylAa9, crylAalO, crylAal 1 crylAbl, crylAb2, crylAb3, crylAb4, crylAbS, crylAb6, crylAb7, crylAb8, crylAb9, crylAblO, crylAbl 1, crylAbl2, crylAbl3, crylAbl4, crylAcl, crylAc2, crylAc3, crylAc4, crylAc5, crylAc6, crylAc7, crylAcB, crylAc9, crylAclO, crylAcl 1, crylAcl2, crylAcl3, cryl Adi, crylAd2, crylAel, crylAfl, ciylAgl, crylBal, crylBa2, crylBbl, crylBcl, crylBdl, crylBel, crylCal, crylCa2, crylCa3, crylCa4, crylCaS, crylCab, crylCa7, crylCbl, crylCb2, crylDal, crylDa2, crylDbl, crylEal, crylEa2, crylEa3, crylEa4, crylEa5, crylEa6, crylEbl, crylFal, crylFa2, crylFbl, crylFb2, crylFb3, crylFb4, crylGal, ciylGa2, crylGbl, crylGb2, crylHal, crylHbl, cryllal, crylla2, crylla3, crylla4, crylla5, crylla6, cryllbl, cryllcl, crylldl, cryllel, cryll-like, crylJal, crylJbl, crylJcl, crylKal, cryl-like, cry2Aal, cry2Aa2, cry2Aa3, cry2Aa4, cry2Aa5, cry2Aa6, cry2Aa7, cry2Aa8, cry2Aa9, cry2Abl, cry2Ab2, cry2Ab3, cry2Acl, cry2Ac2, cry2Adl, cry3Aal, cry3Aa2, cry3Aa3, cry3Aa4, cry3Aa5, cry3Aa6, cry3Aa7, cry3Bal, cry3Ba2, cry3Bbl, cry3Bb2, cry3Bb3, cry3Cal, cry4Aal, cry4Aa2, cry4Ba 1, cry4Ba2, cry4Ba3, cry4Ba4, crySAal, cry5Abl, cry5Ac 1, crySBal, cry6Aal, cry6Bal, cry7Aal, cry7Abl, cry7Ab2, cry8Aal, cry8Bal, cry8Cal, cry9Aal, cry9Aa2, cry9Bal, cry9Cal, cry9Dal, cry9Da2, cry9Eal, cry9 like, crylOAal, crylOAa2, cryllAal, cryllAa2, cryllBal, cry 11 Bb 1, cryl2Aal, cryl3Aal, cryl4Aal, crylSAal, cryl6Aal, cryl7Aal, crylSAal, cryl8Bal, cryl8Cal, cry 19Aal, cryl9Bal, cry20Aal, cry21 Aal, cry21Aa2, cry22Aal, cry23Aal, cry24Aal, cry25Aal, cry26Aal, cry27Aal, cry28Aal, cry28Aa2, cry29Aal, cry30Aal, cry31Aal, cytlAal, cytlAa2, cytlAa3, cytlAa4, cytlAbl, cytlBal, cyt2Aal, cyt2Bal, cyt2Ba2, cyt2Ba3, cyt2Ba4, cyt2Ba5, cyt2Ba6, cyt2Ba7, cyt2Ba8, cyt2Bbl.

Particular preference is given to the genes or gene sections of the subfamilies cryl, cry2, cry3, cry5 and cry9; especially preferred are crylAb, cryl Ac, cry3A, cry3B and cry9C.

Furthermore, it is preferred to use plants which, in addition to the genes for one or more Bt toxins, express or contain, if appropriate, also genes for expressing, for example, a protease or peptidase inhibitor (such as in WO-A 95/35031), of herbicide resistances (for example to glufosinate or glyphosate by expression of the pat gene or bar gene) or for becoming resistant to nematodes, fungi or viruses (for example by expressing a gtuconase, chitinase). However, they may also be modified in their metabolic properties, so that they show a qualitative and/or quantitative change of ingredients (for example by modification of the energy, carbohydrate, fatty acid or nitrogen metabolism or by metabolite currents influencing these (see above). A list of examples of principles of action which can be introduced by genetic modification into a useful plant and which are suitable for the treatment according to the invention on their own or in combination is compiled in Table 2. Under the header “AP” (active principle), this table contains the respective principle of action and associated therewith the pest to be controlled.

In a particularly preferred variant, the process according to the invention is used for treating transgenic vegetable, maize, soya bean, cotton, tobacco, rice, potato and sugar beet varieties. These are preferably Bt plants.

The vegetable plants or varieties are, for example, the following useful plants: o potatoes: preferably starch potatoes, sweet potatoes and table potatoes; o root vegetables: preferably carrots, turnips (swedes, stubble turnips (Brassica rapa var. rapa), spring turnips, autumn turnips (Brassica campestris ssp. rapifera), Brassica rapa L. ssp. rapa f. teltowiensis), scorzonera, Jerusalem artichoke, turnip-rooted parsley, parsnip, radish and horseradish; o tuber vegetables: preferably kohlrabi, beetroot, celeriac, garden radish; o bulb crops: preferably scallion, leek and onions (planting onions and seed onions); o brassica vegetables: preferably headed cabbage (white cabbage, red cabbage, kale, savoy cabbage), cauliflowers, broccoli, curly kale, marrow-stem kale, seakale and Brussels sprouts; o fruiting vegetables: preferably tomatoes (outdoor tomatoes, vine-ripened tomatoes, beef tomatoes, greenhouse tomatoes, cocktail tomatoes, industrial and fresh market tomatoes), melons, eggplants, aubergines, pepper (sweet pepper and hot pepper, Spanish pepper), chilli pepper, pumpkins, courgettes and cucumbers (outdoor cucumbers, greenhouse cucumbers snake gourds and gherkins); o vegetable pulses: preferably bush beans (as sword beans, string beans, flageolet beans, wax beans, com beans of green- and yellow-podded cultivars), pole beans (as sword beans, string beans, flageolet beans, wax beans of green-, blue- and yellow-podded cultivars), broadbeans (field beans, Windsor beans, cultivars having white- and black-spotted flowers), peas (chickling vetch, chickpeas, marrow peas, shelling peas, sugar-peas, smooth peas, cultivars having light- and dark-green fresh fruits) and lentils; o green vegetables and stem vegetables: preferably Chinese cabbage, round-headed garden lettuce, curled lettuce, lamb’s-lettuce, iceberg lettuce, romaine lettuce, oakleaf lettuce, endives, radicchio, lollo rossa, ruccola lettuce, chicory, spinach, chard (leaf chard and stem chard) and parsley; o other vegetables: preferably asparagus, rhubarb, chives, artichokes, mint varieties, sunflowers, Florence fennel, dill, garden cress, mustard, poppy seed, peanuts, sesame und salad chicory.

Bt vegetables including exemplary methods for preparing them are described in detail, for example, in Barton et al., 1987, Plant Physiol. 85 : 1103-1109 ; Vaeck et al., 1987, Nature 328 : 33-37 ; Fischhoff et al., 1987, Bio/Technology 5 : 807-813. In addition, Bt vegetable plants are already known as commercial varieties, for example the potato cultivar NewLeaf® (Monsanto). The preparation of Bt vegetables is also described in US 6,072,105.

Likewise, Bt cotton is already known in principle, for example from US-A-5,322,938 or from Prietro-Samsonor et al., J. Ind. Microbiol. & Biotechn. 1997, 19, 202, and H. Agaisse and D. Lereclus, J. Bacteriol. 1996, 177, 6027. Different varieties of Bt cotton, too, are already commercially available, for example under the name NuCOTN® (Deltapine (USA)). In the context of the present invention, particular preference is given to Bt cotton NuCOTN33® and NuCOTN33B®.

The use and preparation of Bt maize has likewise already been known for a long time, for example from Ishida, Y., Saito, H., Ohta, S., Hiei, Y., Komari, T., and Kumashiro, T. (1996). High efficiency transformation of maize (Zea mayz L.) mediated by Agrobacterium tumefaciens. Nature

Biotechnology 4: 745-750. EP-B-0485506, too, describes the preparation of Bt maize plants. Furthermore, different varieties of Bt maize are commercially available, for example under the following names (company/companies is/are in each case given in brackets): KnockOut® (Novartis Seeds), NaturGard® (Mycogen Seeds), Yieldgard® (Novartis Seeds, Monsanto, Cargill, Golden Harvest, Pioneer, DeKalb inter alia), Bt-Xtra® (DeKalb) and StarLink® (Aventis CropScience, Garst inter alia). For the purpose of the present invention, particular preference is given especially to the following maize cultivars: KnockOut®, NaturGard®, Yieldgard®, Bt-Xtra® and StarLink®.

For soya beans, too, Roundup®Ready cultivar or cultivars resistant to the herbicide Liberty Link® are available and can be treated according to the invention. In the case of rice, a large number of “Golden Rice” lines are available which are likewise characterized in that, by virtue of a transgenic modification, they have an increased content of provitamin A. They, too, are examples of plants which can be treated by the method according to the invention, with the advantages described.

The method according to the invention is suitable for controlling a large number of harmful organisms which occur in particular in vegetables, maize and cotton, preferably arthropods and nematodes, in particular insects and arachnids. The pests mentioned include:

From the order of the Isopoda, for example, Oniscus asellus, Armadillidium vulgare, Porcellio scaber.

From the order of the Diplopoda, for example, Blaniulus guttulatus.

From the order of the Chilopoda, for example, Geophilus carpophagus, Scutigera spp.

From the order of the Symphyla, for example, Scutigerella immaculata.

From the order of the Thysanura, for example, Lepisma saccharina.

From the order of the Collembola, for example, Onychiurus armatus.

From the order of the Orthoptera, for example, Acheta domesticus, Gryllotalpa spp., Locusta migratoria migratorioides, Melanoplus spp., Schistocerca gregaria.

From the order of the Blattaria, for example, Blatta orientalis, Periplaneta americana, Leucophaea maderae, Blattella germanica.

From the order of the Dermaptera, for example, Forficula auricularia.

From the order of the Isoptera, for example, Reticulitermes spp.

From the order of the Phthiraptera, for example, Pediculus humanus corporis, Haematopinus spp., Linognathus spp., Trichodectes spp., Damalinia spp.

From the order of the Thysanoptera, for example, Hercinothrips femoral is, Thrips tabaci, Thrips palmi, Frankliniella occidentalis.

From the order of the Heteroptera, for example, Eurygaster spp., Dysdercus intermedius, Piesma quadrata, Cimex lectularius, Rhodnius prolixus, Triatoma spp.

From the order of the Homoptera, for example, Aleurodes brassicae, Bemisia tabaci, Trialeurodes vaporariorum, Aphis gossypii, Brevicoryne brassicae, Cryptomyzus ribis, Aphis fabae, Aphis pomi, Eriosoma lanigerum, Hyalopterus arundinis, Phylloxera vastatrix, Pemphigus spp., Macrosiphum avenae, Myzus spp., Phorodon humuli, Rhopalosiphum padi, Empoasca spp., Euscelis bilobatus, Nephotettix cincticeps, Lecanium comi, Saissetia oleae, Laodelphax striatellus, Nilaparvata lugens, Aonidiella aurantii, Aspidiotus hederae, Pseudococcus spp., Psylla spp.

From the order of the Lepidoptera, for example, Pectinophora gossypiella, Bupalus piniarius, Cheimatobia brumata, Lithocolletis blancardella, Hyponomeuta padella, Plutella xylostella, Malacosoma neustria, Euproctis chrysorrhoea, Lymantria spp., Bucculatrix thurberiella, Phyllocnistis citrella, Agrotis spp., Euxoa spp., Feltia spp., Earias insulana, Heliothis spp., Mamestra brassicae, Panolis flammea, Spodoptera spp., Trichoplusia ni, Carpocapsa pomonella, Pieris spp., Chilo spp., Pyrausta nubilalis, Ephestia kuehniella, Galleria mellonella, Tineola bisselliella, Tinea pellionella, Hofmannophila pseudospretella, Cacoecia podana, Capua reticulana, Choristoneura fumiferana, Clysia ambiguella, Homona magnanima, Tortrix viridana, Cnaphalocerus spp., Oulema oryzae.

From the order of the Coleoptera, for example, Anobium punctatum, Rhizopertha dominica, Bruchidius obtectus, Acanthoscelides obtectus, Hylotrupes bajulus, Agelastica alni, Leptinotarsa decemlineata, Phaedon cochleariae, Diabrotica spp., Psylliodes chrysocephala, Epilachna varivestis, Atomaria spp., Oryzaephilus surinamensis, Anthonomus spp., Sitophilus spp., Otiorrhynchus sulcatus, Cosmopolites sordidus, Ceuthorrhynchus assimilis, Hypera postica, Dermestes spp., Trogoderma spp., Anthrenus spp., Attagenus spp., Lyctus spp., Meligethes aeneus, Ptinus spp., Niptus hololeucus, Gibbium psylloides, Tribolium spp., Tenebrio molitor, Agriotes spp., Conoderus spp., Melolontha melolontha, Amphimallon solstitialis, Costelytra zealandica, Lissorhoptrus oryzophilus.

From the order of the Hymenoptera, for example, Diprion spp., Hoplocampa spp., Lasius spp., Monomorium pharaonis, Vespa spp.

From the order of the Diptera, for example, Aedes spp., Anopheles spp., Culex spp., Drosophila melanogaster, Musca spp., Fannia spp., Calliphora erythrocephala, Lucilia spp., Chrysomyia spp., Cuterebra spp., Gastrophilus spp., Hyppobosca spp., Stomoxys spp., Oestrus spp., Hypoderma spp., Tabanus spp., Tannia spp., Bibio hortulanus, Oscinella frit, Phorbia spp., Pegomyia hyoscyami, Ceratitis capitata, Dacus oleae, Tipula paludosa, Hylemyia spp., Liriomyza spp.

From the order of the Siphonaptera, for example, Xenopsylla cheopis, Ceratophyllus spp.

From the class of the Arachnida, for example, Scorpio maurus, Latrodectus mactans, Acarus siro, Argas spp., Omithodoros spp., Dermanyssus gallinae, Eriophyes ribis, Phyllocoptruta oleivora, Boophilus spp., Rhipicephalus spp., Amblyomma spp., Hyalomma spp., Ixodes spp., Psoroptes spp., Chorioptes spp., Sarcoptes spp., Tarsonemus spp., Bryobia praetiosa, Panonychus spp., Tetranychus spp., Hemitarsonemus spp., Brevipalpus spp.

The plant-parasitic nematodes include, for example, Pratylenchus spp., Radopholus similis, Ditylenchus dipsaci, Tylenchulus semipenetrans, Heterodera spp., Globodera spp., Meloidogyne spp., Aphelenchoides spp., Longidorus spp., Xiphinema spp., Trichodorus spp., Bursaphelenchus spp.

The method according to the invention is particularly suitable for treating sugar beet or Bt vegetables, Bt maize, Bt cotton, Bt soya beans, Bt tobacco and also Bt rice or Bt potatoes for controlling insects from the order of the Isoptera, for example, Reticulitermes spp., from the order of the Thysanoptera, for example, Thrips tabaci, Thrips palmi, Frankliniella occidentalis, from the order of the Heteroptera, for example, Eurygaster spp., Dysdercus intermedius, Piesma quadrata, from the order of the Homoptera, for example, Aleurodes brassicae, Bemisia tabaci, Trialeurodes vaporariorum, Aphis gossypii, Brevicoryne brassicae, Cryptomyzus ribis, Aphis fabae, Aphis pomi, Eriosoma lanigerum, Phylloxera vastatrix, Pemphigus spp., Macrosiphum avenae, Myzus spp., Phorodon humuli, Rhopalosiphum padi, Empoasca spp., Nephotettix cincticeps, Lecanium comi, Saissetia oleae, Laodelphax striatellus, Nilaparvata lugens, Aonidiella aurantii, Pseudococcus spp., Psylla spp., from the order of the Lepidoptera, for example, Pectinophora gossypiella, Cheimatobia brumata, Lithocolletis blancardella, Hyponomeuta padella, Plutella xylostella, Euproctis chrysorrhoea, Lymantria spp., Phyllocnistis citrella, Agrotis spp., Earias insulana, Heliothis spp., Mamestra brassicae, Spodoptera spp., Trichoplusia ni, Carpocapsa pomonella, Pieris spp., Chilo spp., Pyrausta nubiialis, Ephestia kuehniella, Capua reticulana, Clysia ambiguella, Tortrix viridana, Cnaphalocerus spp., Oulema ory'zae, from the order of the Coleoptera, for example, Leptinotarsa decemlineata, Phaedon cochleariae, Diabrotica spp., Psylliodes chrysocephala, Epilachna varivestis, Atomaria spp., Oryzaephilus surinamensis, Antho-nomus spp., Sitophiius spp., Otiorrhynchus sulcatus, Cosmopolites sordidus, Ceuthorrhynchus assimiiis, Meligethes aeneus, Tribolium spp., Tenebrio molitor, Agriotes spp., Lissorhoptrus oryzophiius, from the order of the Hymenoptera, for example, Diprion spp., Hoplocampa spp. or from the order of the Diptera, for example, Oscinella frit, Phorbia spp., Pegomyia hyoscyami, Ceratitis capitata, Dacus oleae, Hylemyia spp., Liriomyza spp.

The active compound combinations can be employed in customary formulations, such as solutions, emulsions, wettable powders, water- and oil-based suspensions, powders, dusts, pastes, soluble powders, soluble granules, granules for broadcasting, suspoemulsion concentrates, natural compounds impregnated with active compound, synthetic substances impregnated with active compound, fertilizers and also microencapsulations in polymeric substances.

These formulations are prepared in a known manner, for example by mixing the active compounds with extenders, i.e. liquid solvents and/or solid carriers, if appropriate using surfactants, i.e. emulsifiers and/or dispersants and/or foam-formers. The formulations are prepared either in suitable plants or else before or during application.

Wettable powders are preparations which can be dispersed homogeneously in water and which, in addition to the active compound and beside a diluent or inert substance, also comprise wetting agents, for example polyethoxylated alkylphenols, polyethoxylated fatty alcohols, alkylsulphonates or alkylphenylsulphonates and dispersants, for example sodium lignosulphonate, sodium 2,2’-dinaphthylmethane-6,6’-disulphonate.

Dusts are obtained by grinding the active compound with finely distributed solid substances, for example talc, natural clays, such as kaolin, bentonite, pyrophillite or diatomaceous earth. Granules can be prepared either by spraying the active compound onto granular inert material capable of adsorption or by applying active compound concentrates to the surface of carrier substances, such as sand, kaolinites or granular inert material, by means of adhesives, for example polyvinyl alcohol, sodium polyacrylate or mineral oils. Suitable active compounds can also be granulated in the manner customary for the preparation of fertilizer granules - if desired as a mixture with fertilizers.

Suitable for use as auxiliaries are substances which are suitable for imparting to the composition itself and/or to preparations derived therefrom (for example spray liquors, seed dressings) particular properties such as certain technical properties and/or also particular biological properties. Typical suitable auxiliaries are: extenders, solvents and carriers.

Suitable extenders are, for example, water, polar and nonpolar organic chemical liquids, for example from the classes of the aromatic and non-aromatic hydrocarbons (such as paraffins, alkyibenzenes, alkylnaphthalenes, chlorobenzenes), the alcohols and polyols (which, if appropriate, may also be substituted, etherified and/or esterified), the ketones (such as acetone, cyclohexanone), esters (including fats and oils) and (poly)ethers, the unsubstituted and substituted amines, amides, lactams (such as N-alkylpyrrolidones) and lactones, the sulphones and sulphoxides (such as dimethyl sulphoxide).

If the extender used is water, it is also possible to employ, for example, organic solvents as auxiliary solvents. Essentially, suitable liquid solvents are: aromatics such as xylene, toluene or alkylnaphthalenes, chlorinated aromatics and chlorinated aliphatic hydrocarbons such as chlorobenzenes, chloroethylenes or methylene chloride, aliphatic hydrocarbons such as cyclohexane or paraffins, for example petroleum fractions, mineral and vegetable oils, alcohols such as butanol or glycol and also their ethers and esters, ketones such as acetone, methyl ethyl ketone, methyl isobutyl ketone or cyclohexanone, strongly polar solvents such as dimethyl sulphoxide, and also water.

Example of suitable solid carriers are: for example, ammonium salts and ground natural minerals such as kaolins, clays, talc, chalk, quartz, attapulgite, montmorillonite or diatomaceous earth, and ground synthetic minerals, such as finely divided silica, alumina and silicates; suitable solid carriers for granules are: for example, crushed and fractionated natural rocks such as calcite, marble, pumice, sepiolite and dolomite, and also synthetic granules of inorganic and organic meals, and granules of organic material such as paper, sawdust, coconut shells, maize cobs and tobacco stalks; suitable emulsifiers and/or foam-formers are: for example, nonionic and anionic emulsifiers, such as polyoxyethylene fatty acid esters, polyoxyethylene fatty alcohol ethers, for example alkylaryl polyglycol ethers, alkylsulphonates, alkyl sulphates, arylsulphonates and also protein hydrolysates; suitable dispersants are nonionic and/or ionic substances, for example from the classes of the alcohol-POE and/or -POP ethers, acid and/or POP POE esters, alkylaryl and/or POP POE ethers, fat and/or POP POE adducts, POE- and/or POP-polyol derivatives, POE- and/or POP-sorbitan or -sugar adducts, alkyl or aryl sulphates, alkyl-or arylsulphonates and alkyl or aryl phosphates or the corresponding PO-ether adducts. Furthermore, suitable oligo- or polymers, for example those derived from vinylic monomers, from acrylic acid, from EO and/or PO alone or in combination with, for example, (poly)alcohols or (poly)amines. It is also possible to employ lignin and its sulphonic acid derivatives, unmodified and modified celluloses, aromatic and/or aliphatic sulphonic acids and their adducts with formaldehyde.

Tackifiers such as carboxymethylcellulose and natural and synthetic polymers in the form of powders, granules or latices, such as gum arabic, polyvinyl alcohol and polyvinyl acetate, as well as natural phospholipids such as cephalins and lecithins, and synthetic phospholipids, can be used in the formulations.

It is possible to use colorants such as inorganic pigments, for example iron oxide, titanium oxide and Prussian Blue, and organic dyestuffs, such as alizarin dyestuffs, azo dyestuffs and metal phthalocyanine dyestuffs, and trace nutrients such as salts of iron, manganese, boron, copper, cobalt, molybdenum and zinc.

Other possible additives are perfumes, mineral or vegetable, optionally modified oils, waxes and nutrients (including trace nutrients), such as salts of iron, manganese, boron, copper, cobalt, molybdenum and zinc.

Stabilizers, such as low-temperature stabilizers, preservatives, antioxidants, light stabilizers or other agents which improve chemical and/or physical stability may also be present.

These individual types of formulation are known in principle and are described, for example, in: Winnacker-Kiichler, 1986, "Chemische Technologie" [Chemical Technology], Volume 7, 4th Ed., C. Hauser Verlag Munich; van Falkenberg, 1972-73, "Pesticides Formulations", 2nd Ed., Marcel Dekker N.Y.; Martens, 1979, "Spray Drying Handbook", 3rd Ed., G. Goodwin Ltd. London.

Based on his general expert knowledge, the person skilled in the art is able to choose suitable formulation auxiliaries (in this context, see, for example, Watkins, "Handbook of Insecticide Dust Diluents and Carriers", 2nd Ed., Darland Books, Caldwell N.J.; v. Olphen, "Introduction to Clay Colloid Chemistry", 2nd Ed., J. Wiley & Sons, N.Y.; Marsden, "Solvents Guide", 2nd Ed., Interscience, N.Y. 1950; McCutcheon's, "Detergents and Emulsifiers Annual", MC Publ. Corp., Ridgewood, N.J.; Sisley and Wood, "Encyclopedia of Surface Active Agents", Chem. Publ. Co. Inc., N.Y. 1964; Schonfeldt, "Grenzflachenaktive Athylenoxidaddukte" [Surface-active Ethylene Oxide Adducts], Wiss. Verlagsgesell., Stuttgart 1967; Winnacker-Kiichler, "Chemische Technologie" [Chemical Technology], Volume 7,4th Ed., C. Hanser Verlag Munich 1986.

The active compound combinations according to the invention, in commercially available formulations and in the use forms prepared from these formulations, can be present in a mixture with other known active compounds such as insecticides, attractants, sterilants, bactericides, acaricides, nematicides, fungicides, growth regulators or herbicides. The insecticides include, for example, phosphoric esters, carbamates, carboxylic esters, chlorinated hydrocarbons, phenylureas, substances produced by microorganisms, and the like. A mixture with other known active compounds such as herbicides, or with fertilizers and growth regulators, is also possible.

When used as insecticides, the active compound combinations according to the invention in their commercially available formulations and in the use forms which are prepared from these formulations may furthermore be present as a mixture with synergists. Synergists are compounds by which the action of the active compounds is increased without it being necessary for the synergist added to be active itself.

In general, the formulations comprise from 0.01 to 98% by weight of active compound, preferably from 0.5 to 90%. In wettable powders, the active compound concentration is, for example, from about 10 to 90% by weight, the remainder to 100% by weight consisting of customary formulation components. In the case of emulsiftable concentrates, the active compound concentration can be from about 5 to 80% by weight. In most cases, formulations in the form of dusts comprise from 5 to 20% by weight of active compound, sprayable solutions comprise about 2 to 20% by weight. In the case of granules, the active compound content depends partially on whether the active compound is present in liquid or solid form and on which granulation auxiliaries, fillers, etc., are used.

The required application rate may also vary with external conditions such as, inter alia, temperature and humidity. It may vary within wide limits, for example between 0.1 g/h and 5.0 kg/ha or more of active substance. Owing to the synergistic effects between Bt vegetables and the active compound combinations according to the invention, particular preference is given to application rates of from 0.1 to 500 g/ha. Particular preference is given to application rates of from 10 to 500 g/ha, especially preferred are 10 to 200 g/ha.

In their commercial formulations and in the use forms prepared from these formulations, the mixtures according to the invention may be present as mixtures with other active compounds, such as insecticides, attractants, sterilants, acaricides, nematicides, fungicides, growth-regulating substances or herbicides.

The active compound content of the use forms prepared from the commercial formulations may vary within wide limits. The active compound concentration of the use forms may be from 0.0000001 to 95% by weight of active compound and is, preferably between 0.0001 and 1% by weight.

Table 1: Plant: Maize

Structure affected or principle expressed Feature of the plant / tolerance to acetolactate synthase (ALS) sulphonylurea compounds, imidazolinones triazolepyrimidines, pyrimidyloxybenzoates, phthalides acetyl-CoA carboxylase (ACCase) aryloxyphenoxyalkanecarboxylic acid, cyclohexanedione hydroxyphenylpyruvate dioxygenase (HPPD) isooxazoles, such as isoxaflutol or isoxachlortol, triones, such as mesotrione or sulcotrione phosphinothricin acetyltransferase phosphinothricin O-methyl transferase modified lignin content glutamine synthetase glufosinate, bialaphos adenylosuccinate lyase (ADSL) inhibitors of IMP and AMP synthesis adenylosuccinate synthase inhibitors of adenylosuccinate synthesis anthranilate synthase inhibitors of tryptophan synthesis and degradation nitrilase 3,5-dihalo-4-hydroxybenzonitriles, such as bromoxynil and loxinyl 5-enolpyruvyl-3-phosphoshikimate glyphosate or sulphosate synthase (EPSPS) glyphosate oxidoreductase glyphosate or sulphosate protoporphyrinogen oxidase (PROTOX) diphenyl ethers, cyclic imides, phenylpyrazole, pyridine derivative, phenopylate, oxadiazoles etc. cytochrome P450 e.g. P450 SU1 xenobiotics and herbicides, such as sulphonylurea dimboa biosynthesis (Bxl-Gen) Helminthosporium turcicum,

Rhopalosiphum maydis, Diplodia maydis, Ostrinia nubilalis, Lepidoptera sp. CMIII (small basic peptide building block plant pathogens e.g. Fusarium, Altemaria, from maize grain) Sclerotina

Com-SAFP (zeamatin) plant pathogens, e.g. Fusarium,

Altemaria, Sclerotina, Rhizoctonia, Chaetomium, Phycomycen

Hml-gene Cochliobulus

Structure affected or principle expressed Feature of the plant / tolerance to chitinases plant pathogens glucanases plant pathogens envelope proteins viruses, such as the Maize dwarf mosaic virus (MDMV) toxins of Bacillus thuringiensis, VIP 3, Lepidoptera, Coleoptera, Diptera,

Bacillus cereus toxin, Photorabdus and nematodes, e.g. Ostrinia nubilalis,

Xenorhabdus toxins Heliothis zea, armyworms e.g.

Spodoptera frugiperda, Western com rootworm, Sesamia sp., Aprotis ipsilon, Asian com borer, weevils 3-hydroxysteroid oxidase Lepidoptera, Coleoptera, Diptera, nematodes, e.g. Ostrinia nubilalis, Heliothis zea, armyworms e.g. Spodoptera frugiperda,

Western com rootworm, Sesamia sp., Aprotis ipsilon,

Asian com borer, weevils peroxidase Lepidoptera, Coleoptera, Diptera, nematodes, e.g. Ostrinia nubilalis, Heliothis zea, armyworms e.g. Spodoptera frugiperda,

Western com rootworm, Sesamia sp., Aprotis ipsilon, Asian com borer, weevils aminopeptidase inhibitors, e.g. leucine Lepidoptera, Coleoptera, Diptera, aminopeptidase inhibitors (LAPI) nematodes, e.g. Ostrinia nubilalis,

Heliothis zea, armyworms e.g. Spodoptera frugiperda, Western com rootworm, Sesamia sp., Aprotis ipsilon, Asian com borer, weevils limonene synthase Western com rootworm lectin Lepidoptera, Coleoptera, Diptera, nematodes, e.g. Ostrinia nubilalis, Heliothis zea, armyworms e.g. Spodoptera frugiperda,

Western com rootworm, Sesamia sp., Aprotis ipsilon, Asian com borer, weevils protease inhibitors e.g. cystatin, patatin, weevils, Western com rootworm

virgiferin, CPTI ribosome-inactivating protein Lepidoptera, Coleoptera, Diptera, nematodes, e.g. Ostrinia nubilalis, Heliothis zea,

Structure affected or principle expressed Feature of the plant / tolerance to armyworms e.g. Spodoptera frugiperda, Western com rootworm, Sesamia sp., Aprotis ipsilon, Asian com borer, weevils 5C9-maize polypeptide Lepidoptera, Coleoptera, Diptera, nematodes, e.g. Ostrinia nubilalis, Heliothis zea, armyworms e.g. Spodoptera frugiperda, Western com rootworm, Sesamia sp., Aprotis ipsilon, Asian com borer, weevils HMG-CoA reductase Lepidoptera, Coleoptera, Diptera, nematodes, e.g. Ostrinia nubilalis, Heliothis zea, armyworms e.g. Spodoptera frugiperda, Western com rootworm, Sesamia sp., Aprotis ipsilon, Asian com borer, weevils

Plant: Wheat

Structure affected/ protein expressed Feature of the plant / tolerance to acetolactate synthase (ALS) sulphonylurea compounds, imidazolinones triazolepyrimidines, pyrimidyloxybenzoates, phthalides acetyl-CoA carboxylase (ACCase) aryloxyphenoxyalkanecarboxylic acid, cyclohexanedione hydroxyphenylpyruvate dioxygenase (HPPD) isooxazoles, such as isoxaflutol or isoxachlortol, triones, such as mesotrione or sulcotrione phosphinothricin acetyltransferase phosphinothricin O-methyl transferase modified lignin content glutamine synthetase glufosinate, bialaphos adenylosuccinate lyase (ADSL) inhibitors of IMP and AMP synthesis adenylosuccinate synthase inhibitors of adenylosuccinate synthesis anthranilate synthase inhibitors of tryptophan synthesis and degradation nitrilase 3,5-dihalo-4-hydroxybenzonitriles, such as bromoxynil and loxinyl 5-enolpyruvyl-3-phosphoshildmate glyphosate or sulphosate synthase (EPSPS)

Structure affected / protein expressed Feature of the plant / tolerance to glyphosate oxidoreductase glyphosate or sulphosate protoporphyrinogen oxidase (PROTOX) diphenyl ethers, cyclic imides, phenylpyrazoles, pyridine derivatives, phenopylate, oxadiazoles etc. cytochrome P450 e.g. P450 SU1 xenobiotics and herbicides, such as sulphonylurea compounds antifungal polypeptide AlyAFP plant pathogens, e.g. Septoria and Fusarium glucose oxidase plant pathogens, e.g. Fusarium, Septoria pyrrolnitrin synthesis gene plant pathogens, e.g. Fusarium, Septoria serine/threonine kinases plant pathogens, e.g. Fusarium, Septoria and other diseases polypeptide having the effect of triggering plant pathogens, e.g. Fusarium, Septoria and a hypersensitivity reaction other diseases systemic aquired resistance (SAR) genes viral, bacterial, fungal and nematodal pathogens chitinases plant pathogens glucanases plant pathogens double-strand ribonuclease viruses such as, for example, BYDV and

MSMV envelope proteins viruses such as, for example, BYDV and

MSMV toxins of Bacillus thuringiensis, VIP 3, Lepidoptera, Coleoptera, Diptera,

Bacillus cereus toxins, Photorabdus and nematodes

Xenorhabdus toxins 3-hydroxysteroid oxidase Lepidoptera, Coleoptera, Diptera, nematodes peroxidase Lepidoptera, Coleoptera, Diptera, nematodes aminopeptidase inhibitors, e.g. leucine Lepidoptera, Coleoptera, Diptera, aminopeptidase inhibitor nematodes lectins Lepidoptera, Coleoptera, Diptera, nematodes, aphids protease inhibitors, e.g. cystatin, patatin, Lepidoptera, Coleoptera, Diptera, virgiferin, CPTI nematodes, aphids ribosome-inactivating protein Lepidoptera, Coleoptera, Diptera, nematodes, aphids

Structure affected / protein expressed Feature of the plant / tolerance to HMG-CoA reductase Lepidoptera, Coleoptera, Diptera, nematodes, e.g. Ostrinia nubilalis,

Heliothis zea, armyworms e.g. Spodoptera frugiperda, Western com rootworm, Sesamia sp., Aprotis ipsilon, Asian com borer, weevils

Plant: Barley

Structure affected/ protein expressed Feature of the plant / tolerance to acetolactate synthase (ALS) sulphonylurea compounds, imidazolinones triazolepyrimidines, pyrimidyloxybenzoates, phthalides acetyl-Co A carboxylase (ACCase) aryloxyphenoxyalkanecarboxylic acids, cyclohexanediones hydroxyphenylpyruvate dioxygenase (HPPD) isooxazoles, such as isoxaflutol or isoxachlortol, triones, such as mesotrione or sulcotrione phosphinothricin acetyltransferase phosphinothricin O-methyl transferase modified lignin content glutamine synthetase glufosinate, bialaphos adenylosuccinate lyase (ADSL) inhibitors of IMP and AMP synthesis adenylosuccinate synthase inhibitors of adenylosuccinate synthesis anthranilate synthase inhibitors of tryptophan synthesis and degradation nitrilase 3,5-dihalo-4-hydroxybenzonitriles, such as bromoxynil and loxinyl 5-enolpyruvyl-3-phosphoshikimate glyphosate or sulphosate synthase (EPSPS) glyphosate oxidoreductase glyphosate or sulphosate protoporphyrinogen oxidase (PROTOX) diphenyl ethers, cyclic imides, phenylpyrazoles, pyridine derivatives, phenopylate, oxadiazoles etc. cytochrome P450 e.g. P450 SU1 xenobiotics and herbicides, such as sulphonylurea compounds antifungal polypeptide AlyAFP plant pathogens, e.g. Septoria and Fusarium glucose oxidase plant pathogens, e.g. Fusarium, Septoria

Structure affected / protein expressed Feature of the plant / tolerance to pyrrolnitrin synthesis gene plant pathogens, e.g. Fusarium, Septoria serine/threonine kinases plant pathogens, e.g. Fusarium, Septoria and other diseases polypeptide having the effect of triggering plant pathogens, e.g. Fusarium, Septoria and a hypersensitivity reaction other diseases systemic aquired resistance (SAR) genes viral, bacterial, fungal and nematodal pathogens chitinases plant pathogens glucanases plant pathogens double-strand ribonuclease viruses such as, for example, BYDV and

MSMV envelope proteins viruses such as, for example, BYDV and

MSMV toxins of Bacillus thuringiensis, VIP 3, Lepidoptera, Coleoptera, Diptera,

Bacillus cereus toxins, Photorabdus and nematodes

Xenorhabdus toxins 3-hydroxysteroid oxidase Lepidoptera, Coleoptera, Diptera, nematodes peroxidase Lepidoptera, Coleoptera, Diptera, nematodes ami nopeptidase inhibitors, e.g. leucine Lepidoptera, Coleoptera, Diptera, aminopeptidase inhibitor nematodes lectins Lepidoptera, Coleoptera, Diptera, nematodes, aphids protease inhibitors, e.g. cystatin, patatin, Lepidoptera, Coleoptera, Diptera, virgiferin, CPTI nematodes, aphids ribosome-inactivating protein Lepidoptera, Coleoptera, Diptera, nematodes, aphids HMG-CoA reductase Lepidoptera, Coleoptera, Diptera, nematodes, aphids

Plant: Rice

Structure affected/ principle expressed Feature of the plant / tolerance to acetolactate synthase (AJLS) sulphonylurea compounds, imidazolinones triazolepyrimidines, pyrimidyloxybenzoates,

Structure affected/ principle expressed Feature of the plant / tolerance to phthalides acetyl-CoA carboxylase (ACCase) aryloxyphenoxyalkanecarboxylic acid, cyclohexanedione hydroxyphenylpyruvate dioxygenase (HPPD) isooxazoles, such as isoxaflutol or isoxachlortol, triones, such as mesotrione or sulcotrione phosphinothricin acetyltransferase phosphinothricin O-methyl transferase modified lignin content glutamine synthetase glufosinate, bialaphos adenylosuccinate lyase (ADSL) inhibitors of IMP and AMP synthesis adenylosuccinate synthase inhibitors of adenylosuccinate synthesis anthranilate synthase inhibitors of tryptophan synthesis and degradation nitrilase 3,5-dihalo-4-hydroxybenzonitriles, such as bromoxyni! and loxinyl 5-enolpyruvy 1-3 -phosphoshikimate glyphosate or sulphosate synthase (EPSPS) glyphosate oxidoreductase glyphosate or sulphosate protoporphyrinogen oxidase (PROTOX) diphenyl ethers, cyclic imides, phenylpyrazoles, pyridine derivatives, phenopylate, oxadiazoles etc. cytochrome P450 e.g. P450 SU1 xenobiotics and herbicides, such as sulphonylurea compounds antifungal polypeptide AlyAFP plant pathogens glucose oxidase plant pathogens pyrrolnitrin synthesis gene plant pathogens serine/threonine kinases plant pathogens phenylalanine ammonia lyase (PAL) plant pathogens, e.g. bacterial foliar mildew and inducible rice blast phytoalexins plant pathogens, e.g. bacterial foliar mildew and rice blast B-l,3-glucanase (antisense) plant pathogens, e.g. bacterial foliar mildew and rice blast receptor kinase plant pathogens, e.g. bacterial foliar mildew and rice blast polypeptide having the effect of triggering plant pathogens

Structure affected/ principle expressed Feature of the plant / tolerance to a hypersensitivity reaction systemic aquired resistance (SAR) genes viral, bacterial, fungal and nematodal pathogens chitinases plant pathogens, e.g. bacterial foliar mildew and rice blast glucanases plant pathogens double-strand ribonuclease viruses such as, for example, BYDV and

MSMV envelope proteins viruses such as, for example, BYDV and

MSMV toxins of Bacillus thuringiensis, VIP 3, Lepidoptera, e.g. stem borer, Coleoptera,

Bacillus cereus toxins, Photorabdus and e.g. weevils such as Lissorhoptrus oryzophilus,

Xenorhabdus toxins Diptera, rice planthoppers, e.g. rice brown planthopper 3-hydroxysteroid oxidase Lepidoptera, e.g. stem borer, Coleoptera, e.g. weevils such as Lissorhoptrus oryzophilus, Diptera, rice planthoppers, e.g. rice brown planthopper peroxidase Lepidoptera, e.g. stem borer, Coleoptera, e.g. weevils such as Lissorhoptrus oryzophilus, Diptera, rice planthoppers, e.g. rice brown planthopper aminopeptidase inhibitors, e.g. leucine Lepidoptera, e.g. stem borer, Coleoptera, aminopeptidase inhibitor e.g. weevils such as Lissorhoptrus oryzophilus, Diptera, rice planthoppers, e.g. rice brown planthopper lectins Lepidoptera, e.g. stem borer, Coleoptera, e.g. weevils such as Lissorhoptrus oryzophilus, Diptera, rice planthoppers, e.g. rice brown planthopper protease inhibitors Lepidoptera, e.g. stem borer, Coleoptera, e.g. weevils such as Lissorhoptrus oryzophilus, Diptera, rice planthoppers e.g. rice brown planthopper ribosome-inactivating protein Lepidoptera, e.g. stem borer, Coleoptera, e.g. weevils such as Lissorhoptrus

Structure affected/ principle expressed Feature of the plant / tolerance to oryzophilus, Diptera, rice planthoppers, e.g. rice brown planthopper HMG-CoA reductase Lepidoptera, e.g. stem borer, Coleoptera, e.g. weevils such as Lissorhoptrus oryzophilus, Diptera, rice planthoppers e.g. rice brown planthopper

Plant: Soya bean

Structure affected/ principle expressed Feature of the plant / tolerance to acetolactate synthase (ALS) sulphonylurea compounds, imidazolinones triazolepyrimidines, pyrimidyloxybenzoates, phthalides acetyl-CoA carboxylase (ACCase) aryloxyphenoxyalkanecarboxylic acids, cyclohexanediones hydroxyphenylpyruvate dioxygenase (HPPD) isooxazoles, such as isoxaflutol or isoxachlortol, triones, such as mesotrione or sulcotrione phosphinothricin acetyltransferase phosphinothricin O-methyl transferase modified lignin content glutamine synthetase glufosinate, bialaphos adenylosuccinate lyase (ADSL) inhibitors of IMP and AMP synthesis adenylosuccinate synthase inhibitors of adenylosuccinate synthesis anthranilate synthase inhibitors of tryptophan synthesis and degradation nitrilase 3,5-dihalo-4-hydroxybenzonitriles, such as bromoxynil and loxinyl 5-enolpyruvyi-3-phosphoshikimate glyphosate or sulphosate synthase (EPSPS) glyphosate oxidoreductase glyphosate or sulphosate protoporphyrinogen oxidase (PROTOX) diphenyl ethers, cyclic imides, phenylpyrazoles, pyridine derivatives, phenopylate, oxadiazoles etc. cytochrome P450 e.g. P450 SU1 or selection xenobiotics and herbicides, such as sulphonylurea compounds antifungal polypeptide AlyAFP bacterial and fungal pathogens such as, for

Structure affected/ principle expressed Feature of the plant / tolerance to example, Fusarium, Sclerotinia, stem rot oxalate oxidase bacterial and fungal pathogens such as, for example, Fusarium, Sclerotinia, stem rot glucose oxidase bacterial and fungal pathogens such as, for example, Fusarium, Sclerotinia, stem rot pyrrolnitrin synthesis gene bacterial and fungal pathogens such as, for example, Fusarium, Sclerotinia, stem rot serine/threonine kinases bacterial and fungal pathogens such as, for example, Fusarium, Sclerotinia, stem rot phenylalanine ammonia lyase (PAL) bacterial and fungal pathogens such as, for example, Fusarium, Sclerotinia, stem rot phytoalexins plant pathogens, e.g. bacterial foliar mildew and rice blast B-l,3-glucanase (antisense) plant pathogens, e.g. bacterial foliar mildew and rice blast receptor kinase bacterial and fungal pathogens such as, for example, Fusarium, Sclerotinia, stem rot polypeptide having the effect of triggering plant pathogens a hypersensitivity reaction systemic aquired resistance (SAR) genes viral, bacterial, fungal and nematodal pathogens chitinases bacterial and fungal pathogens such as, for example, Fusarium, Sclerotinia, stem rot glucanases bacterial and fungal pathogens such as, for example, Fusarium, Sclerotinia, stem rot double-strand ribonuclease viruses such as, for example, BPMV and

SbMV envelope proteins viruses such as, for example, BYDV and

MSMV toxins of Bacillus thuringiensis, VIP 3, Lepidoptera, Coleoptera, aphids

Bacillus cereus toxins, Photorabdus and Xenorhabdus toxins 3-hydroxysteroid oxidase Lepidoptera, Coleoptera, aphids peroxidase Lepidoptera, Coleoptera, aphids aminopeptidase inhibitors, e.g. leucine Lepidoptera, Coleoptera, aphids aminopeptidase inhibitor

Structure affected/ principle expressed Feature of the plant / tolerance to lectins Lepidoptera, Coleoptera, aphids protease inhibitors, e.g. virgiferin Lepidoptera, Coleoptera, aphids ribosome-inactivating protein Lepidoptera, Coleoptera, aphids HMG-CoA reductase Lepidoptera, Coleoptera, aphids bamase nematodes, e.g. root-knot nematodes and cyst nematodes hatching factor for cyst nematodes cyst nematodes principles for preventing food uptake nematodes, e.g. root-knot nematodes and cyst nematodes

Plant: Potato

Structure affected / protein expressed Feature of the plant / tolerance to acetolactate synthase (ALS) sulphonylurea compounds, imidazolinones triazolepyrimidines, pyrimidyloxybenzoates, phthalides acetyl-CoA carboxylase (ACCase) aryloxyphenoxyalkanecarboxylic acids, cyclohexanediones hydroxyphenylpyruvate dioxygenase (HPPD) isooxazoles, such as isoxaflutol or isoxachlortol, triones, such as mesotrione or sulcotrione phosphinothricin acetyltransferase phosphinothricin O-methyl transferase modified lignin content glutamine synthetase glufosinate, bialaphos adenylosuccinate lyase (ADSL) inhibitors of IMP and AMP synthesis adenylosuccinate synthase inhibitors of adenylosuccinate synthesis anthranilate synthase inhibitors of tryptophan synthesis and degradation nitrilase 3,5-dihalo-4-hydroxybenzonitriles, such as bromoxynil and loxinyl 5-enolpyruvyl-3-phosphoshikimate glyphosate or sulphosate synthase (EPSPS) glyphosate oxidoreductase glyphosate or sulphosate protoporphyrinogen oxidase (PROTOX) diphenyl ethers, cyclic imides, phenylpyrazoles, pyridine derivatives, phenopylate, oxadiazoles etc.

Structure affected / protein expressed Feature of the plant / tolerance to cytochrome P450 e.g. P450 SU1 or selection xenobiotics and herbicides, such as sulphonylurea compounds polyphenol oxidase or polyphenol oxidase black spot (antisense) metallothionein bacterial and fungal pathogens such as, for example, Phytophtora, ribonuclease Phytophtora, Verticillium, Rhizoctonia antifungal polypeptide AlyAFP bacterial and fungal pathogens such as, for example, Phytophtora oxalate oxidase bacterial and fungal pathogens such as, for example, Phytophtora, Verticillium, Rhizoctonia glucose oxidase bacterial and fungal pathogens such as, for example, Phytophtora, Verticillium, Rhizoctonia pyrrolnitrin synthesis gene bacterial and fungal pathogens such as, for example, Phytophtora, Verticillium, Rhizoctonia serine/threonine kinases bacterial and fungal pathogens such as, for example, Phytophtora, Verticillium, Rhizoctonia cecropin B bacteria such as, for example, Coryne- bacterium sepedonicum, Erwinia carotovora phenylalanine ammonia lyase (PAL) bacterial and fungal pathogens such as, for example, Phytophtora, Verticillium, Rhizoctonia phytoalexins bacterial and fungal pathogens such as, for example, Phytophtora, Verticillium, Rhizoctonia B-l,3-glucanase (antisense) bacterial and fungal pathogens such as, for example, Phytophtora, Verticillium, Rhizoctonia receptor kinase bacterial and fungal pathogens such as, for example, Phytophtora, Verticillium, Rhizoctonia polypeptide having the effect of triggering bacterial and fungal pathogens such as, for

Structure affected / protein expressed Feature of the plant / tolerance to a hypersensitivity reaction example, Phytophtora, Verticillium, Rhizoc- tonia systemic aquired resistance (SAR) genes viral, bacterial, fungal and nematodal pathogens chitinases bacterial and fungal pathogens such as, for example, Phytophtora, Verticillium, Rhizoc-tonia bamase bacterial and fungal pathogens such as, for example, Phytophtora, Verticillium, Rhizoc- tonia gene 49 for controlling disease resistance bacterial and fungal pathogens such as, for example, Phytophtora, Verticillium, Rhizoc-tonia trans-aldolase (antisense) black spot glucanases bacterial and fungal pathogens such as, for example, Phytophtora, Verticillium, Rhizoc- tonia double-strand ribonuclease viruses such as, for example, PLRV, PVY and

TRV envelope proteins viruses such as, for example, PLRV, PVY and

TRV 17kDa or 60 kDa protein viruses such as, for example, PLRV, PVY and

TRV nuclear inclusion proteins, e.g. a or b viruses such as, for example, PLRV, PVY and

TRV pseudoubiquitin viruses such as, for example, PLRV, PVY and

TRV replicase viruses such as, for example, PLRV, PVY and

TRV toxins of Bacillus thuringiensis, VIP 3, Coleoptera, e.g. Colorado beetle, aphids

Bacillus cereus toxins, Photorabdus and Xenorhabdus toxins 3-hydroxysteroid oxidase Coleoptera, e.g. Colorado beetle, aphids peroxidase Coleoptera, e.g. Colorado beetle, aphids aminopeptidase inhibitors, e.g. leucine Coleoptera, e.g. Colorado beetle, aphids aminopeptidase inhibitor

Structure affected / protein expressed Feature of the plant / tolerance to stilbene synthase Coleoptera, e.g. Colorado beetle, aphids lectins Coleoptera, e.g. Colorado beetle, aphids protease inhibitors, e.g. cystatin, patatin Coleoptera, e.g. Colorado beetle, aphids ribosomene-inactivating protein Coleoptera, e.g. Colorado beetle, aphids HMG-CoA reductase Coleoptera, e.g. Colorado beetle, aphids hatching factor for cyst nematodes cyst nematodes bamase nematodes, e.g. root-knot nematodes and cyst nematodes principles for preventing food uptake nematodes, e.g. root-knot nematodes and cyst nematodes

Plant: Tomato

Structure affected/ principle expressed Feature of the plant / tolerance to acetolactate synthase (ALS) sulphonylurea compounds, imidazolinones triazolepyrimidines, pyrimidyloxybenzoates, phthalides acetyl-CoA carboxylase (ACCase) aryloxyphenoxyalkanecarboxylic acid, cyclohexanedione hydroxyphenylpyruvate dioxygenase (HPPD) isooxazoles, such as isoxaflutol or isoxachlortol, triones, such as mesotrione or sulcotrione phosphinothricin acetyltransferase phosphinothricin O-methyl transferase modified lignin content glutamine synthetase glufosinate, bialaphos adenylosuccinate lyase (ADSL) inhibitors of IMP and AMP synthesis adenylosuccinate synthase inhibitors of adenylosuccinate synthesis anthranilate synthase inhibitors of tryptophan synthesis and degradation • nitrilase 3,5-dihalo-4-hydroxybenzonitriles, such as bromoxynil and loxinyl 5-enolpyruvyl-3-phosphoshikimate glyphosate or sulphosate synthase (EPSPS) glyphosate oxidoreductase glyphosate or sulphosate protoporphyrinogen oxidase (PROTOX) diphenyl ethers, cyclic imides, phenylpyrazoles, pyridine derivatives,

Structure affected/ principle expressed Feature of the plant / tolerance to phenopylate, oxadiazoles etc.

Cytochrome P450 e.g. P450 SU1 or selection xenobiotics and herbicides, such as sulphonylurea compounds polyphenol oxidase or polyphenol oxidase black spot (antisense) metallothionein bacterial and fungal pathogens such as, for example, Phytophtora ribonuclease Phytophtora, Verticillium, Rhizoctonia antifungal polypeptide AlyAFP bacterial and fungal pathogens such as, for example, bacterial blotch, Fusarium, soft rot, powdery mildew, foliar blight, leaf mould etc. oxalate oxidase bacterial and fungal pathogens such as, for example, bacterial blotch, Fusarium, soft rot, powdery mildew, foliar blight, leaf mould etc. glucose oxidase bacterial and fungal pathogens such as, for example, bacterial blotch, Fusarium, soft rot, powdery mildew, foliar blight, leaf mould etc. pyrrolnitrin synthesis gene bacterial and fungal pathogens such as, for example, bacterial blotch, Fusarium, soft rot, powdery mildew, foliar blight, leaf mould etc. serine/threonine kinases bacterial and fungal pathogens such as, for example, bacterial blotch, Fusarium, soft rot, powdery mildew, foliar blight, leaf mould etc. cecropin B bacterial and fungal pathogens such as, for example, bacterial blotch, Fusarium, soft rot, powdery mildew, foliar blight, leaf mould etc. phenylalanine ammonia lyase (PAL) bacterial and fungal pathogens such as, for example, bacterial blotch, Fusarium, soft rot, powdery mildew, foliar blight, leaf mould etc.

Structure affected/ principle expressed Feature of the plant / tolerance to

Cf genes, e.g. Cf 9 Cf5 Cf4 Cf2 leaf mould osmotin early blight alpha hordothionin bakteria systemin bacterial and fungal pathogens such as, for example, bacterial blotch, Fusarium, soft rot, powdery mildew, foliar blight, leaf mould etc. polygalacturonase inhibitors bacterial and fungal pathogens such as, for example, bacterial blotch, Fusarium, soft rot, powdery mildew, foliar blight, leaf mould etc.

Prf control gene bacterial and fungal pathogens such as, for example, bacterial blotch, Fusarium, soft rot, powdery mildew, foliar blight, leaf mould etc. 12 fusarium resistance site Fusarium phytoalexins bacterial and fungal pathogens such as, for example, bacterial blotch, Fusarium, soft rot, powdery mildew, foliar blight, leaf mould etc. B-l,3-glucanase (antisense) bacterial and fungal pathogens such as, for example, bacterial blotch, Fusarium, soft rot, powdery mildew, foliar blight, leaf mould etc. receptor kinase bacterial and fungal pathogens such as, for example, bacterial blotch, Fusarium, soft rot, powdery mildew, foliar blight, leaf mould etc. polypeptide having the effect of triggering bacterial and fungal pathogens such as, for a hypersensitivity reaction example, bacterial blotch, Fusarium, soft rot, powdery mildew, foliar blight, leaf mould etc. systemic aquired resistance (SAR) genes viral, bacterial, fungal and nematodal pathogens chitinases bacterial and fungal pathogens such as, for example, bacterial blotch, Fusarium,

Structure affected/ principle expressed Feature of the plant / tolerance to soft rot, powdery mildew, foliar blight, leaf mould etc. bamase bacterial and fungal pathogens such as, for example, bacterial blotch, Fusarium, soft rot, powdery mildew, foliar blight, leaf mould etc. glucanases bacterial and fungal pathogens such as, for example, bacterial blotch, Fusarium, soft rot, powdery mildew, foliar blight, leaf mould etc. double-strand ribonuclease viruses such as, for example, PLRV, PVY and

ToMoV envelope proteins viruses such as, for example, PLRV, PVY and

ToMoV 17kJDa or 60 kDa protein viruses such as, for example, PLRV, PVY and

ToMoV nuclear inclusion proteins e.g. a or b or viruses such as, for example, PLRV, PVY and

ToMoV

nucleoprotein TRV pseudoubiquitin viruses such as, for example, PLRV, PVY and

ToMoV replicase viruses such as, for example, PLRV, PVY and

ToMoV toxins of Bacillus thuringiensis, VIP 3, Lepidoptera e.g. Heliothis, whitefly

Bacilluscereus toxins, Photorabdus and aphids

Xenorhabdus toxins 3-hydroxysteroid oxidase Lepidoptera e.g. Heliothis, whitefly, aphids peroxidase Lepidoptera e.g. Heliothis, whitefly, aphids aminopeptidase inhibitors, e.g. leucine Lepidoptera e.g. Heliothis, whitefly, aminopeptidase inhibitor aphids lectins Lepidoptera e.g. Heliothis, whitefly, aphids protease inhibitors, e.g. cystatin, patatin Lepidoptera e.g. Heliothis, whitefly, aphids

Structure affected/ principle expressed Feature of the plant / tolerance to ribosome-inactivating protein Lepidoptera e.g. Heliothis, whitefly, aphids stilbene synthase Lepidoptera e.g. Heliothis, whitefly, aphids HMG-CoA reductase Lepidoptera e.g. Heliothis, whitefly, aphids hatching factor for cyst nematodes cyst nematodes bamase nematodes, e.g. root-knot nematodes and cyst nematodes principles for preventing food uptake nematodes, e.g. root-knot nematodes and cyst nematodes

Plant: Bell Pepper

Structure affected / protein expressed Feature of the plant / tolerance to acetolactate synthase (ALS) sulphonylurea compounds, imidazolinones triazolopyrimidines, pyrimidyloxybenzoates, phthalides acetyl-CoA carboxylase (ACCase) aryloxyphenoxyalkanecarboxylic acids, cyclohexanediones hydroxyphenylpyruvate dioxygenase (HPPD) isoxazoles such as, for example, isoxaflutole or isoxachlortole, triones such as, for example, mesotrione or sulcotrione phosphinothricin acetyltransferase phosphinothricin O-methyl transferase modified lignin content glutamine synthetase glufosinate, bialaphos adenylosuccinate lyase (ADSL) inhibitors of IMP and AMP synthesis adenylosuccinate synthase inhibitors of adenylosuccinate synthesis anthranilate synthase inhibitors of tryptophan synthesis and degradation nitrilase 3,5-dihalo-4-hydroxybenzonitriles such as bromoxynil and loxinyl 5-enolpyruvyl-3-phosphoshikimate glyphosate or sulphosate synthase (EPSPS) glyphosate oxidoreductase glyphosate or sulphosate protoporphyrinogen oxidase (PROTOX) diphenyl ethers, cyclic imides,

Structure affected / protein expressed Feature of the plant/ tolerance to phenylpyrazoles, pyridine derivatives, phenopylate, oxadiazoles etc. cytochrome P450 e.g. P450 SU1 or selection xenobiotics and herbicides such as, for example, sulphonylurea compounds polyphenol oxidase or polyphenol oxidase bacterial and fungal pathogens (antisense) metallothionein bacterial and fungal pathogens ribonuclease bacterial and fungal pathogens antifungal polypeptid AlyAFP bacterial and fungal pathogens oxalate oxidase bacterial and fungal pathogens glucose oxidase bacterial and fungal pathogens pyrrolnitrin synthesis genes bacterial and fungal pathogens serine/threonine kinases bacterial and fungal pathogens cecropin B bacterial and fungal pathogens, rot, leaf mould, etc. phenylalanine ammonia lyase (PAL) bacterial and fungal pathogens

Cf genes, e.g. Cf 9 Ct5 Cf4 Cf2 bacterial and fungal pathogens osmotin bacterial and fungal pathogens alpha hordothionine bacterial and fungal pathogens systemin bacterial and fungal pathogens polygalacturonase inhibitors bacterial and fungal pathogens

Prf control gene bacterial and fungal pathogens 12 Fusarium resistance site Fusarium phytoalexins bacterial and fungal pathogens B-l,3-glucanase (antisense) bacterial and fungal pathogens receptor kinase bacterial and fungal pathogens polypeptide having the effect of triggering bacterial and fungal pathogens a hypersensitivity reaction systemic aquired resistance (SAR) genes viral, bacterial, fungal and nematodal pathogens chitinases bacterial and fungal pathogens bamase bacterial and fungal pathogens glucanases bacterial and fungal pathogens

double-strand ribonuclease viruses such as, for example, CMV, TEV

envelope proteins viruses such as, for example, CMV, TEV

17kDa or 60 kDa protein viruses such as, for example, CMV, TEV

Structure affected / protein expressed Feature of the plant / tolerance to

nuclear inclusion proteins e.g. a or b or viruses such as, for example, CMV, TEV nucleoprotein

pseudoubiquitin viruses such as, for example, CMV, TEV

replicase viruses such as, for example, CMV, TEV toxins of Bacillus thuringiensis, VIP 3, Lepidoptera, whitefly, aphids

Bacilluscereus toxins, Photorabdus and Xenorhabdus toxins 3-hydroxysteroid oxidase Lepidoptera, whitefly, aphids peroxidase Lepidoptera, whitefly, aphids aminopeptidase inhibitors, e.g. leucine Lepidoptera, whitefly, aphids aminopeptidase inhibitor lectins Lepidoptera, whitefly, aphids protease inhibitors, e.g. cystatin, patatin Lepidoptera, whitefly, aphids ribosome-inactivating protein Lepidoptera, whitefly, aphids stilbene synthase Lepidoptera, whitefly, aphids HMG-CoA reductase Lepidoptera, whitefly, aphids hatching factor for cyst nematodes cyst nematodes bamase nematodes, e.g. root-knot nematodes and cyst nematodes principles for preventing food uptake nematodes, e.g. root-knot nematodes and cyst nematodes

Plant: Grapevines

Structure affected/ principle expressed Feature of the plant / tolerance to acetolactate synthase (ALS) sulphonylurea compounds, imidazolinones triazolopyrimidines, pyrimidyloxybenzoates, phthalides acetyl-CoA carboxylase (ACCase) aryloxyphenoxyalkanecarboxylic acids, cyclohexanediones hydroxyphenylpyruvate dioxygenase (HPPD) isoxazoles such as, for example, isoxaflutole or isoxachlortole, triones such as, for example, mesotrione or sulcotrione phosphinothricin acetyltransferase phosphinothricin O-methyl transferase modified lignin content glutamine synthetase glufosinate, bialaphos

Structure affected/ principle expressed Feature of the plant / tolerance to adenylosuccinate lyase (ADSL) inhibitors of IMP and AMP synthesis adenylosuccinate synthase inhibitors of adenylosuccinate synthesis anthranilate synthase inhibitors of tryptophan synthesis and degradation nitrilase 3,5-dihalo-4-hydroxybenzonitriles such as bromoxynil and loxinyl 5-enolpyruvyl-3-phosphoshikimate glyphosate or sulphosate synthase (EPSPS) glyphosate oxidoreductase glyphosate or sulphosate protoporphyrinogen oxidase (PROTOX) diphenyl ethers, cyclic imides, phenylpyrazoles, pyridine derivatives, phenopylate, oxadiazoles etc. cytochrome P450 e.g. P450 SU1 or selection xenobiotics and herbicides such as, for example, sulphonylurea compounds polyphenol oxidase or polyphenol oxidase bacterial and fungal pathogens such as (antisense) Botrytis and powdery mildew metallothionein bacterial and fungal pathogens such as

Botrytis and powdery mildew ribonuclease bacterial and fungal pathogens such as

Botrytis and powdery mildew antifungal polypeptide AlyAFP bacterial and fungal pathogens such as

Botrytis and powdery mildew oxalate oxidase bacterial and fungal pathogens such as

Botrytis and powdery mildew glucose oxidase bacterial and fungal pathogens such as

Botrytis and powdery mildew pyrrolnitrin synthesis genes bacterial and fungal pathogens such as

Botrytis and powdery mildew serine/threonine kinases bacterial and fungal pathogens such as

Botrytis and powdery mildew cecropin B bacterial and fungal pathogens such as

Botrytis and powdery mildew phenylalanine ammonia lyase (PAL) bacterial and fungal pathogens such as

Botrytis and powdery mildew

Cf genes, e.g. Cf 9 Cf5 Cf4 Cf2 bacterial and fungal pathogens such as

Botrytis and powdery mildew

Structure affected/ principle expressed Feature of the plant / tolerance to osmotin bacterial and fungal pathogens such as

Botrytis and powdery mildew alpha hordothionine bacterial and fungal pathogens such as

Botrytis and powdery mildew systemin bacterial and fungal pathogens such as

Botrytis and powdery mildew polygalacturonase inhibitors bacterial and fungal pathogens such as

Botrytis and powdery mildew

Prf control gene bacterial and fungal pathogens such as

Botrytis and powdery mildew phytoalexins bacterial and fungal pathogens such as

Botrytis and powdery mildew B-l,3-glucanase (antisense) bacterial and fungal pathogens such as

Botrytis and powdery mildew receptor kinase bacterial and fungal pathogens such as

Botrytis and powdery mildew polypeptide having the effect of triggering bacterial and fungal pathogens such as Botrytis a hypersensitivity reaction and powdery mildew systemic aquired resistance (SAR) genes viral, bacterial, fungal and nematodal pathogens chitinases bacterial and fungal pathogens such as

Botrytis and powdery mildew bamase bacterial and fungal pathogens such as

Botrytis and powdery mildew glucanases bacterial and fungal pathogens such as Botrytis and powdery mildew double-strand ribonuclease viruses envelope proteins viruses 17kDa or 60 kDa protein viruses nuclear inclusion proteins e.g. a or b or viruses nucleoprotein pseudoubiquitin viruses replicase viruses toxins of Bacillus thuringiensis, VIP 3, Lepidoptera, aphids

Bacilluscereus toxins, Photorabdus and

Xenorhabdus toxins

Structure affected/ principle expressed Feature of the plant / tolerance to 3-hydroxysteroid oxidase Lepidoptera, aphids peroxidase Lepidoptera, aphids aminopeptidase inhibitors, e.g. leucine Lepidoptera, aphids aminopeptidase inhibitor lectins Lepidoptera, aphids protease inhibitors, e.g. cystatin, patatin Lepidoptera, aphids ribosome-inactivating protein Lepidoptera, aphids stilbene synthase Lepidoptera, aphids, diseases HMG-CoA reductase Lepidoptera, aphids hatching factor for cyst nematodes cyst nematodes bamase nematodes, e.g. root-knot nematodes and cyst nematodes or general diseases CBI root-knot nematodes principles for preventing food uptake nematodes, e.g. root-knot nematodes or root-cyst nematodes

Plant: Oilseed rape

Structure affected / protein expressed Feature of the plant / tolerance to acetolactate synthase (ALS) sulphonylurea compounds, imidazolinones triazolopyrimidines, pyrimidyloxybenzoates, phthalides acetyl-CoA carboxylase (ACCase) aryloxyphenoxyalkanecarboxylic acids, cyclohexanediones hydroxyphenylpyruvate dioxygenase (HPPD) isoxazoles such as, for example, isoxaflutole or isoxachlortole, triones such as, for example, mesotrione or sulcotrione phosphinothricin acetyltransferase phosphinothricin O-methyl transferase modified lignin content glutamine synthetase glufosinate, bialaphos adenylosuccinate lyase (ADSL) inhibitors of IMP and AMP synthesis adenylosuccinate synthase inhibitors of adenylosuccinate synthesis anthranilate synthase inhibitors of tryptophan synthesis and degradation nitrilase 3,5-dihalo-4-hydroxybenzonitriles such as bromoxynil and loxinyl

Structure affected / protein expressed Feature of the plant / tolerance to 5-enolpyruvyl-3-phosphoshikimate glyphosate or sulphosate synthase (EPSPS) glyphosate oxidoreductase glyphosate or sulphosate protoporphyrinogen oxidase (PROTOX) diphenyl ethers, cyclic imides, phenylpyrazoles, pyridine derivatives, phenopylate, oxadiazoles etc. cytochrome P450 e.g. P450 SU1 or selection xenobiotics and herbicides such as, for example, sulphonylurea compounds polyphenol oxidase or polyphenol oxidase bacterial and fungal pathogens such as (antisense) Cylindrosporium, Phoma, Sclerotinia metallothionein bacterial and fungal pathogens such as

Cylindrosporium, Phoma, Sclerotinia ribonuclease bacterial and fungal pathogens such as

Cylindrosporium, Phoma, Sclerotinia antifungal polypeptid AlyAPP bacterial and fungal pathogens such as

Cylindrosporium, Phoma, Sclerotinia oxalate oxidase bacterial and fungal pathogens such as

Cylindrosporium, Phoma, Sclerotinia glucose oxidase bacterial and fungal pathogens such as

Cylindrosporium, Phoma, Sclerotinia pyrrolnitrin synthesis genes bacterial and fungal pathogens such as

Cylindrosporium, Phoma, Sclerotinia serine/threonine kinases bacterial and fungal pathogens such as

Cylindrosporium, Phoma, Sclerotinia cecropin B bacterial and fungal pathogens such as

Cylindrosporium, Phoma, Sclerotinia phenylalanine ammonia lyase (PAL) bacterial and fungal pathogens such as

Cylindrosporium, Phoma, Sclerotinia

Cf genes, e.g. Cf 9 Cf5 Cf4 CG bacterial and fungal pathogens such as

Cylindrosporium, Phoma, Sclerotinia osmotin bacterial and fungal pathogens such as

Cylindrosporium, Phoma, Sclerotinia alpha hordothionine bacterial and fungal pathogens such as

Cylindrosporium, Phoma, Sclerotinia systemin bacterial and fungal pathogens such as

Cylindrosporium, Phoma, Sclerotinia polygalacturonase inhibitors bacterial and fungal pathogens such as

Cylindrosporium, Phoma, Sclerotinia

Prf control gene bacterial and fungal pathogens such as

Cylindrosporium, Phoma, Sclerotinia

Structure affected / protein expressed Feature of the plant / tolerance to phytoalexins bacterial and fungal pathogens such as

Cylindrosporium, Phoma, Sclerotinia B-l,3-glucanase (antisense) bacterial and fungal pathogens such as

Cylindrosporium, Phoma, Sclerotinia receptor kinase bacterial and fungal pathogens such as

Cylindrosporium, Phoma, Sclerotinia polypeptide having the effect of triggering bacterial and fungal pathogens such as , .,. ., ,. Cylindrosporium, Phoma, Sclerotinia a hypersensitivity reaction J r systemic aquired resistance (SAR) genes viral, bacterial, fungal and nematoda! pathogens chitinases bacterial and fungal pathogens such as

Cy 1 i ndrosporium, Phoma, Sclerotinia bamase bacterial and fungal pathogens such as

Cylindrosporium, Phoma, Sclerotinia nematodes glucanases bacterial and fungal pathogens such as

Cylindrosporium, Phoma, Sclerotinia double-strand ribonuclease viruses envelope proteins viruses 17kDa or 60 kDa protein viruses nuclear inclusion proteins e.g. a or b or viruses nucleoprotein pseudoubiquitin viruses replicase viruses toxins of Bacillus thuringiensis, VIP 3, Lepidoptera, aphids

Bacilluscereus toxins, Photorabdus and

Xenorhabdus toxins 3-hydroxysteroid oxidase Lepidoptera, aphids peroxidase Lepidoptera, aphids aminopeptidase inhibitors, e.g. leucine Lepidoptera, aphids aminopeptidase inhibitor lectins Lepidoptera, aphids protease inhibitors, e.g. cystatin, patatin, Lepidoptera, aphids

CPTI ribosome-inactivating protein Lepidoptera, aphids stilbene synthase Lepidoptera, aphids, diseases HMG-CoA reductase Lepidoptera, aphids

Structure affected / protein expressed Feature of the plant / tolerance to hatching factor for cyst nematodes cyst nematodes bamase nematodes, e.g. root-knot nematodes and cyst nematodes CBI root-knot nematodes principles for preventing food uptake nematodes, e.g. root-knot nematodes and induced at nematode feeding sites root-cyst nematodes

Plant: Brassica vegetables (cabbage, Brussels sprouts etc.)

Structure affected / protein expressed Feature of the plant / tolerance to acetolactate synthase (ALS) sulphonylurea compounds, imidazolinones triazolopyrimidines, pyrimidyloxybenzoates, phthalides acetyl-CoA carboxylase (ACCase) aryloxyphenoxyalkanecarboxylic acids, cyclohexanediones hydroxyphenylpyruvate dioxygenase (HPPD) isoxazoles such as, for example, isoxaflutole or isoxachlortole, triones such as, for example, mesotrione or sulcotrione phosphinothricin acetyltransferase phosphinothricin O-methyl transferase modified lignin content glutamine synthetase glufosinate, bialaphos adenylosuccinate lyase (ADSL) inhibitors of IMP and AMP synthesis adenylosuccinate synthase inhibitors of adenylosuccinate synthesis anthranilate synthase inhibitors of tryptophan synthesis and degradation nitrilase 3,5-dihalo-4-hydroxybenzonitriles such as bromoxynil and loxinyl 5-enolpyruvyl-3-phosphoshikimate glyphosate or sulphosate synthase (EPSPS) glyphosate oxidoreductase glyphosate or sulphosate protoporphyrinogen oxidase (PROTOX) diphenyl ethers, cyclic imides, phenylpyrazoles, pyridine derivatives, phenopylate, oxadiazoles etc. cytochrome P450 e.g. P450 SU1 or selection xenobiotics and herbicides such as, for

Structure affected / protein expressed Feature of the plant / tolerance to example, sulphonylurea compounds polyphenol oxidase or polyphenol oxidase bacterial and fungal pathogens (antisense) metallothionein bacterial and fungal pathogens ribonuclease bacterial and fungal pathogens antifungal polypeptid AlyAFP bacterial and fungal pathogens oxalate oxidase bacterial and fungal pathogens glucose oxidase bacterial and fungal pathogens pyrrolnitrin synthesis genes bacterial and fungal pathogens serine/threonine kinases bacterial and fungal pathogens cecropin B bacterial and fungal pathogens phenylalanine ammonia lyase (PAL) bacterial and fungal pathogens

Cf genes, e.g. Cf 9 Cf5 Cf4 Cf2 bacterial and fungal pathogens osmotin bacterial and fungal pathogens alpha hordothionine bacterial and fungal pathogens systemin bacterial and fungal pathogens polygalacturonase inhibitors bacterial and fungal pathogens

Prf control gene bacterial and fungal pathogens phytoalexins bacterial and fungal pathogens B-l ,3-glucanase (antisense) bacterial and fungal pathogens receptor kinase bacterial and fungal pathogens polypeptide having the effect of triggering bacterial and fungal pathogens a hypersensitivity reaction systemic aquired resistance (SAR) genes viral, bacterial, fungal and nematodal pathogens chitinases bacterial and fungal pathogens bamase bacterial and fungal pathogens glucanases bacterial and fungal pathogens double-strand ribonuclease viruses envelope proteins viruses 17kDa or 60 kDa protein viruses nuclear inclusion proteins e.g. a or b or viruses nucleoprotein pseudoubiquitin viruses replicase viruses toxins of Bacillus thuringiensis, VIP 3, Lepidoptera, aphids

Structure affected / protein expressed Feature of the plant / tolerance to

Bacitluscereus toxins, Photorabdus and Xenorhabdus toxins 3-hydroxysteroid oxidase Lepidoptera, aphids peroxidase Lepidoptera, aphids aminopeptidase inhibitors, e.g. leucine Lepidoptera, aphids aminopeptidase inhibitor lectins Lepidoptera, aphids protease inhibitors, e.g. cystatin, patatin, Lepidoptera, aphids

CPTI ribosome-inactivating protein Lepidoptera, aphids stilbene synthase Lepidoptera, aphids, diseases HMG-CoA reductase Lepidoptera, aphids hatching factor for cyst nematodes cyst nematodes bamase nematodes, e.g. root-knot nematodes and cyst nematodes CBI root-knot nematodes principles for preventing food uptake nematodes, e.g. root-knot nematodes and induced at nematode feeding sites root-cyst nematodes cyst nematodes

Plants: Pomaceous fruit, e.g. apples, pears

Structure affected / protein expressed Feature of the plant / tolerance to acetolactate synthase (ALS) sulphonylurea compounds, imidazolinones triazolopyrimidines, pyrimidyloxybenzoates, phthal ides acetyl-CoA carboxylase (ACCase) aryloxyphenoxyalkanecarboxylic acids, cyclohexanediones hydroxyphenylpyruvate dioxygenase (HPPD) isoxazoles such as, for example, isoxaflutole or isoxachlortole, triones such as, for example, mesotrione or sulcotrione phosphinothricin acetyltransferase phosphinothricin O-methyl transferase modified lignin content glutamine synthetase glufosinate, bialaphos adenylosuccinate lyase (ADSL) inhibitors of IMP and AMP synthesis adenylosuccinate synthase inhibitors of adenylosuccinate synthesis

Structure affected / protein expressed Feature of the plant / tolerance to anthranilate synthase inhibitors of tryptophan synthesis and degradation nitrilase 3,5~dihalo-4-hydroxybenzonitriles such as bromoxynil and loxinyl 5-enoipyruvyl-3-phosphoshikimate glyphosate or sulphosate synthase (EPSPS) glyphosate oxidoreductase glyphosate or sulphosate protoporphyrinogen oxidase (PROTOX) diphenyl ethers, cyclic imides, phenylpyrazoles, pyridine derivatives, phenopylate, oxadiazoles etc. cytochrome P450 e.g. P450 SU1 or selection xenobiotics and herbicides such as, for example, sulphonylurea compounds polyphenol oxidase or polyphenol oxidase bacterial and fungal pathogens such as (antisense) storage scab on apples or fire-blight metallothionein bacterial and fungal pathogens such as storage scab on apples or fire-blight ribonuclease bacterial and fungal pathogens such as storage scab on apples or fire-blight antifungal polypeptid AlyAFP bacterial and fungal pathogens such as storage scab on apples or fire-blight oxalate oxidase bacterial and fungal pathogens such as storage scab on apples or fire-blight glucose oxidase bacterial and fungal pathogens such as storage scab on apples or fire-blight pyrrolnitrin synthesis genes bacterial and fungal pathogens such as storage scab on apples or fire-blight serine/threonine kinases bacterial and fungal pathogens such as storage scab on apples or fire-blight cecropin B bacterial and fungal pathogens such as storage scab on apples or fire-blight phenylalanine ammonia lyase (PAL) bacterial and fungal pathogens such as storage scab on apples or fire-blight

Cf genes, e.g. Cf 9 Cf5 Cf4 Cf2 bacterial and fungal pathogens such as storage scab on apples or fire-blight osmotin bacterial and fungal pathogens such as storage scab on apples or fire-blight

Structure affected / protein expressed Feature of the plant / tolerance to alpha hordothionine bacterial and fungal pathogens such as storage scab on apples or fire-blight systemin bacterial and fungal pathogens such as storage scab on apples or fire-blight polygalacturonase inhibitors bacterial and fungal pathogens such as storage scab on apples or fire-blight

Prf control gene bacterial and fungal pathogens such as storage scab on apples or fire-blight phytoalexins bacterial and fungal pathogens such as storage scab on apples or fire-blight B-l,3-glucanase (antisense) bacterial and fungal pathogens such as storage scab on apples or fire-blight receptor kinase bacterial and fungal pathogens such as storage scab on apples or fire-blight polypeptide having the effect of triggering bacterial and fungal pathogens such as a hypersensitivity reaction storage scab on apples or fire-blight systemic aquired resistance (SAR) genes viral, bacterial, fungal and nematodal pathogens lytic protein bacterial and fungal pathogens such as storage scab on apples or fire-blight lysozyme bacterial and fungal pathogens such as storage scab on apples or fire-blight chitinases bacterial and fungal pathogens such as storage scab on apples or fire-blight bamase bacterial and fungal pathogens such as storage scab on apples or fire-blight glucanases bacterial and fungal pathogens such as storage scab on apples or fire-blight double-strand ribonuclease viruses envelope proteins viruses 17kDa or 60 kDa protein viruses nuclear inclusion proteins e.g. a or b or viruses nucleoprotein pseudoubiquitin viruses replicase viruses toxins of Bacillus thuringiensis, VIP 3, Lepidoptera, aphids, mites

Structure affected / protein expressed Feature of the plant / tolerance to

Bacilluscereus toxins, Photorabdus and Xenorhabdustoxins 3-hydroxysteroid oxidase Lepidoptera, aphids, mites peroxidase Lepidoptera, aphids, mites aminopeptidase inhibitors, e.g. leucine Lepidoptera, aphids, mites aminopeptidase inhibitor lectins Lepidoptera, aphids, mites protease inhibitors, e.g. cystatin, patatin, Lepidoptera, aphids, mites

CPTI ribosome-inactivating protein Lepidoptera, aphids, mites stilbene synthase Lepidoptera, aphids, diseases, mites HMG-CoA reductase Lepidoptera, aphids, mites hatching factor for cyst nematodes cyst nematodes bamase nematodes, e.g. root-knot nematodes and cyst nematodes CBI root-knot nematodes principles for preventing food uptake nematodes, e.g. root-knot nematodes and induced at nematode feeding sites root-cyst nematodes

Plant: Melon

Structure affected / protein expressed Feature of the plant / tolerance to acetolactate synthase (ALS) sulphonylurea compounds, imidazolinones triazolopyrimidines, pyrimidyloxybenzoates, phthalides acetyl-CoA carboxylase (ACCase) aryloxyphenoxyalkanecarboxylic acids, cyclohexanediones hydroxyphenylpyruvate dioxygenase (HPPD) isoxazoles such as, for example, isoxaflutole or isoxachlortole, triones such as, for example, mesotrione or sulcotrione phosphinothricin acetyltransferase phosphinothricin O-methyl transferase modified lignin content glutamine synthetase glufosinate, bialaphos adenylosuccinate lyase (ADSL) inhibitors of IMP and AMP synthesis adenylosuccinate synthase inhibitors of adenylosuccinate synthesis anthranilate synthase inhibitors of tryptophan synthesis and

Structure affected / protein expressed Feature of the plant / tolerance to degradation nitriiase 3,5-dihalo-4-hydroxybenzonitriles such as bromoxynil and loxinyl 5-enolpyruvyl-3-phosphoshikimate glyphosate or sulphosate synthase (EPSPS) glyphosate oxidoreductase glyphosate or sulphosate protoporphyrinogen oxidase (PROTOX) diphenyl ethers, cyclic imides, phenylpyrazoles, pyridine derivatives, phenopylate, oxadiazoles etc. cytochrome P450 e.g. P450 SU1 or selection xenobiotics and herbicides such as, for example, sulphonylurea compounds polyphenol oxidase or polyphenol oxidase bacterial or fungal pathogens such as (antisense) Phytophtora metallothionein bacterial or fungal pathogens such as

Phytophtora ribonuclease bacterial or fungal pathogens such as

Phytophtora antifungal polypeptid AlyAFP bacterial or fungal pathogens such as

Phytophtora oxalate oxidase bacterial or fungal pathogens such as

Phytophtora glucose oxidase bacterial or fungal pathogens such as

Phytophtora pyrrolnitrin synthesis genes bacterial or fungal pathogens such as

Phytophtora serine/threonine kinases bacterial or fungal pathogens such as

Phytophtora cecropin B bacterial or fungal pathogens such as

Phytophtora phenylalanine ammonia lyase (PAL) bacterial or fungal pathogens such as

Phytophtora

Cf genes, e.g. Cf 9 Cf5 Cf4 Cf2 bacterial or fungal pathogens such as

Phytophtora osmotin bacterial or fungal pathogens such as

Phytophtora alpha hordothionine bacterial or fungal pathogens such as

Structure affected / protein expressed Feature of the plant / tolerance to

Phytophtora systemin bacterial or fungal pathogens such as

Phytophtora polygalacturonase inhibitors bacterial or fungal pathogens such as

Phytophtora

Prf control gene bacterial or fungal pathogens such as

Phytophtora phytoalexins bacterial or fungal pathogens such as

Phytophtora B-l,3-glucanase (antisense) bacterial or fungal pathogens such as

Phytophtora receptor kinase bacterial or fungal pathogens such as

Phytophtora polypeptide having the effect of triggering bacterial or fungal pathogens such as a hypersensitivity reaction Phytophtora systemic aquired resistance (SAR) genes viral, bacterial, fungal and nematodal pathogens lytic protein bacterial or fungal pathogens such as

Phytophtora lysozyme bacterial or fungal pathogens such as

Phytophtora chitinases bacterial or fungal pathogens such as

Phytophtora bamase bacterial or fungal pathogens such as

Phytophtora glucanases bacterial or fungal pathogens such as

Phytophtora double-strand ribonuclease viruses such as CMV, PRSV, WMV2, SMV,

ZYMV envelope proteins viruses such as CMV, PRSV, WMV2, SMV,

ZYMV 17kDa or 60 kDa protein viruses such as CMV, PRSV, WMV2, SMV,

ZYMV nuclear inclusion proteins e.g. a or b or viruses such as CM V, PRSV, WMV2, SMV,

nucleoprotein ZYMV pseudoubiquitin viruses such as CMV, PRSV, WMV2, SMV,

Structure affected / protein expressed Feature of the plant / tolerance to ΖΫΜΫ replicase viruses such as CMV, PRSV, WMV2, SMV,

ZYMV toxins of Bacillus thuringiensis, VIP 3, Lepidoptera, aphids, mites

Bacilluscereus toxins, Photorabdus and Xenorhabdus toxins 3-hydroxysteroid oxidase Lepidoptera, aphids, mites, whitefly peroxidase Lepidoptera, aphids, mites, whitefly aminopeptidase inhibitors, e.g. leucine Lepidoptera, aphids, mites, whitefly aminopeptidase inhibitor lectins Lepidoptera, aphids, mites, whitefly protease inhibitors, e.g. cystatin, patatin, Lepidoptera, aphids, mites, whitefly CPTI, virgiferin ribosome-inactivating protein Lepidoptera, aphids, mites, whitefly stilbene synthase Lepidoptera, aphids, mites, whitefly HMG-CoA reductase Lepidoptera, aphids, mites, whitefly hatching factor for cyst nematodes cyst nematodes bamase nematodes, e.g. root-knot nematodes and cyst nematodes CBI root-knot nematodes principles for preventing food uptake nematodes, e.g. root-knot nematodes and induced at nematode feeding sites root-cyst nematodes

Plant: Banana

Structure affected / protein expressed Feature of the plant / tolerance to acetolactate synthase (ALS) sulphonylurea compounds, imidazolinones triazolopyrimidines, pyrimidyloxybenzoates, phthalides acetyl-CoA carboxylase (ACCase) aryloxyphenoxyalkanecarboxylic acids, cyclohexanediones hydroxyphenylpyruvate dioxygenase (HPPD) isoxazoles such as, for example, isoxaflutole or isoxachlortole, triones such as, for example, mesotrione or sulcotrione phosphinothricin acetyltransferase phosphinothricin

Structure affected / protein expressed Feature of the plant / tolerance to O-methyl transferase modified lignin content glutamine synthetase glufosinate, bialaphos adenylosuccinate lyase (ADSL) inhibitors of IMP and AMP synthesis adenylosuccinate synthase inhibitors of adenylosuccinate synthesis anthranilate synthase inhibitors of tryptophan synthesis and degradation nitrilase 3,5-dihalo-4-hydroxybenzonitriles such as bromoxynil and loxinyl 5-enoipyruvyl-3-phosphoshikimate glyphosate or sulphosate synthase (EPSPS) glyphosate oxidoreductase glyphosate or sulphosate protoporphyrinogen oxidase (PROTOX) diphenyl ethers, cyclic imides, phenylpyrazoles, pyridine derivatives, phenopylate, oxadiazoles etc. cytochrome P450 e.g. P450 SU1 or selection xenobiotics and herbicides such as, for example, sulphonylurea compounds polyphenol oxidase or polyphenol oxidase bacterial or fungal pathogens (antisense) metallothionein bacterial or fungal pathogens ribonuclease bacterial or fungal pathogens antifungal polypeptid AlyAFP bacterial or fungal pathogens oxalate oxidase bacterial or fungal pathogens glucose oxidase bacterial or fungal pathogens pyrrolnitrin synthesis genes bacterial or fungal pathogens serine/threonine kinases bacterial or fungal pathogens cecropin B bacterial or fungal pathogens phenylalanine ammonia lyase (PAL) bacterial or fungal pathogens

Cf genes, e.g. Cf 9 Cf5 Cf4 Cf2 bacterial or fungal pathogens osmotin bacterial or fungal pathogens alpha hordothionine bacterial or fungal pathogens systemin bacterial or fungal pathogens polygalacturonase inhibitors bacterial or fungal pathogens

Prf control gene bacterial or fungal pathogens phytoalexins bacterial or fungal pathogens B-l ,3-glucanase (antisense) bacterial or fungal pathogens receptor kinase bacterial or fungal pathogens

Structure affected / protein expressed Feature of the plant / tolerance to polypeptide having the effect of triggering bacterial or fungal pathogens a hypersensitivity reaction systemic aquired resistance (SAR) genes viral, bacterial, fungal and nematodal pathogens lytic protein bacterial or fungal pathogens lysozyme bacterial or fungal pathogens chitinases bacterial or fungal pathogens bamase bacterial or fungal pathogens glucanases bacterial or fungal pathogens double-strand ribonuclease viruses such as the Banana Bunchy Top Virus (BBTV) envelope proteins viruses such as the Banana Bunchy Top Virus (BBTV) 17kDa or 60 kDa protein viruses such as the Banana Bunchy Top Virus (BBTV) nuclear inclusion proteins e.g. a or b or viruses such as the Banana Bunchy Top Virus nucleoprotein (BBTV) pseudoubiquitin viruses such as the Banana Bunchy Top Virus (BBTV) replicase viruses such as the Banana Bunchy Top Virus (BBTV) toxins of Bacillus thuringiensis, VIP 3, Lepidoptera, aphids, mites, nematodes

Bacilluscereus toxins, Photorabdus and Xenorhabdus toxins 3-hydroxysteroid oxidase Lepidoptera, aphids, mites, nematodes peroxidase Lepidoptera, aphids, mites, nematodes aminopeptidase inhibitors, e.g. leucine Lepidoptera, aphids, mites, nematodes aminopeptidase inhibitor lectins Lepidoptera, aphids, mites, nematodes protease inhibitors, e.g. cystatin, patatin, Lepidoptera, aphids, mites, nematodes CPTI, virgiferin ribosome-inactivating protein Lepidoptera, aphids, mites, nematodes stilbene synthase Lepidoptera, aphids, mites, nematodes HMG-CoA reductase Lepidoptera, aphids, mites, nematodes hatching factor for cyst nematodes cyst nematodes bamase nematodes, e.g. root-knot nematodes and

Structure affected / protein expressed Feature of the plant / tolerance to cyst nematodes CBI root-knot nematodes principles for preventing food uptake nematodes, e.g. root-knot nematodes and induced at nematode feeding sites root-cyst nematodes

Plant: Cotton

Structure affected / protein expressed Feature of the plant / tolerance to acetolactate synthase (ALS) sulphonylurea compounds, imidazolinones triazolopyrimidines, pyrimidyloxybenzoates, phthalides acetyl-CoA carboxylase (ACCase) aryloxyphenoxyalkanecarboxylic acids, cyclohexanediones hydroxyphenylpyruvate dioxygenase (HPPD) isoxazoles such as, for example, isoxaflutole or isoxachlortole, triones such as, for example, mesotrione or sulcotrione phosphinothricin acetyltransferase phosphinothricin O-methyl transferase modified lignin content glutamine synthetase glufosinate, bialaphos adenylosuccinate lyase (ADSL) inhibitors of IMP and AMP synthese adenylosuccinate synthase inhibitors of adenylosuccinate synthesis anthranilate synthase inhibitors of tryptophan synthesis and degradation nitrilase 3,5-dihalo-4-hydroxybenzonitriles such as bromoxynil and loxinyl 5-enolpyruvyl-3-phosphoshikimate glyphosate or sulphosate synthase (EPSPS) glyphosate oxidoreductase glyphosate or sulphosate protoporphyrinogen oxidase (PROTOX) diphenyl ethers, cyclic imides, phenylpyrazoles, pyridine derivatives, phenopylate, oxadiazoles etc. cytochrome P450 e.g. P450 SU1 or selection xenobiotics and herbicides such as, for example, sulphonylurea compounds polyphenol oxidase or polyphenol oxidase bacterial or fungal pathogens (antisense) metallothionein bacterial or fungal pathogens ribonuclease bacterial or fungal pathogens antifungal polypeptid AlyAFP bacterial or fungal pathogens oxalate oxidase bacterial or fungal pathogens glucose oxidase bacterial or fungal pathogens pyrrolnitrin synthesis genes bacterial or fungal pathogens serine/threonine kinases bacterial or fungal pathogens cecropin B bacterial or fungal pathogens phenylalanine ammonia lyase (PAL) bacterial or fungal pathogens

Cf genes, e.g. Cf 9 Cf5 Cf4 Cf2 bacterial or fungal pathogens osmotin bacterial or fungal pathogens alpha hordothionine bacterial or fungal pathogens systemin bacterial or fungal pathogens polygalacturonase inhibitors bacterial or fungal pathogens

Prf control gene bacterial or fungal pathogens phytoalexins bacterial or fungal pathogens B-l,3-glucanase (antisense) bacterial or fungal pathogens receptor kinase bacterial or fungal pathogens polypeptide having the effect of triggering bacterial or fungal pathogens a hypersensitivity reaction systemic aquired resistance (SAR) genes viral, bacterial, fungal and nematodal pathogens lytic protein bacterial or fungal pathogens lysozyme bacterial or fungal pathogens chitinases bacterial or fungal pathogens bamase bacterial or fungal pathogens glucanases bacterial or fungal pathogens double-strand ribonuclease viruses such as the wound tumour virus (WTV) envelope proteins viruses such as the wound tumour virus (WTV) 17kDa or 60 kDa protein viruses such as the wound tumour virus (WTV) nuclear inclusion proteins e.g. a or b or viruses such as the wound tumour virus (WTV) nucleoprotein pseudoubiquitin viruses such as the wound tumour virus (WTV) replicase viruses such as the wound tumour virus (WTV) toxins of Bacillus thuringiensis, VIP 3, Lepidoptera, aphids, mites, nematodes,

Bacilluscereus toxins, Photorabdus and whitefly

Xenorhabdus toxins 3-hydroxysteroid oxidase Lepidoptera, aphids, mites, nematodes, whitefly peroxidase Lepidoptera, aphids, mites, nematodes, whitefly aminopeptidase inhibitors, e.g. leucine Lepidoptera, aphids, mites, nematodes, aminopeptidase inhibitor whitefly lectins Lepidoptera, aphids, mites, nematodes, whitefly protease inhibitors, e.g. cystatin, patatin, Lepidoptera, aphids, mites, nematodes, CPU, virgiferin whitefly ribosome-inactivating protein Lepidoptera, aphids, mites, nematodes, whitefly stilbene synthase Lepidoptera, aphids, mites, nematodes, whitefly HMG-CoA reductase Lepidoptera, aphids, mites, nematodes, whitefly hatching factor for cyst nematodes cyst nematodes bamase nematodes, e.g. root-knot nematodes and cyst nematodes CB1 root-knot nematodes principles for preventing food uptake nematodes, e.g. root-knot nematodes and induced at nematode feeding sites root-cyst nematodes

Plant: Sugar cane

Feature affected / protein expressed Feature of the plant / tolerance to acetolactate synthase (ALS) sulphonylurea compounds, imidazolinones triazolopyrimidines, pyrimidyloxybenzoates, phthalides acetyl-CoA carboxylase (ACCase) aryloxyphenoxyalkanecarboxylic acids, cyclohexanediones hydroxyphenylpyruvate dioxygenase (HPPD) isoxazoles such as, for example, isoxaflutole or isoxachlortole, triones such as, for example, mesotrione or sulcotrione phosphinothricin acetyltransferase phosphinothricin O-methyl transferase modified lignin content glutamine synthetase glufosinate, bialaphos

Feature affected / protein expressed Feature of the plant/ tolerance to adenylosuccinate lyase (ADSL) inhibitors of IMP and AMP synthesis adenylosuccinate synthase inhibitors of adenylosuccinate synthesis anthranilate synthase inhibitors of tryptophan synthesis and degradation nitrilase 3,5-dihalo-4-hydroxybenzonitriles such as bromoxynil and loxinyl 5-enolpyruvyl-3-phosphoshikimate glyphosate or sulphosate synthase (EPSPS) glyphosate oxidoreductase glyphosate or sulphosate protoporphyrinogen oxidase (PROTOX) diphenyl ethers, cyclic imides, phenylpyrazoles, pyridine derivatives, phenopylate, oxadiazoles etc. cytochrome P450 e.g. P450 SU1 or selection xenobiotics and herbicides such as, for example, sulphonylurea compounds polyphenol oxidase or polyphenol oxidase bacterial or fungal pathogens (antisense) metallothionein bacterial or fungal pathogens ribonuclease bacteria! or fungal pathogens antifungal polypeptid AlyAFP bacterial or fungal pathogens oxalate oxidase bacterial or fungal pathogens glucose oxidase bacterial or fungal pathogens pyrrolnitrin synthesis genes bacterial or fungal pathogens serine/threonine kinases bacterial or fungal pathogens cecropin B bacterial or fungal pathogens phenylalanine ammonia lyase (PAL) bacterial or fungal pathogens

Cf genes, e.g. Cf 9 Cf5 Cf4 Cf2 bacterial or fungal pathogens osmotin bacterial or fungal pathogens alpha hordothionine bacterial or fungal pathogens systemin bacterial or fungal pathogens polygalacturonase inhibitors bacterial or fungal pathogens

Prf control gene bacterial or fungal pathogens phytoalexins bacterial or fungal pathogens B-l,3-glucanase (antisense) bacterial or fungal pathogens receptor kinase bacterial or fungal pathogens polypeptide having the effect of triggering bacterial or fungal pathogens a hypersensitivity reaction

Feature affected / protein expressed Feature of the plant / tolerance to systemic aquired resistance (SAR) genes viral, bacterial, fiungal and nematodal pathogens lytic protein bacterial or fungal pathogens lysozyme bacterial or fungal pathogens, e.g.

Clavibacter chitinases bacterial or fungal pathogens bamase bacterial or fungal pathogens giucanases bacterial or fungal pathogens

double-strand ribonuclease viruses such as SCMV, SrMV

envelope proteins viruses such as SCMV, SrMV

17kDa or 60 kDa protein viruses such as SCMV, SrMV

nuclear inclusion proteins e.g. a or b or viruses such as SCMV, SrMV nucleoprotein

pseudoubiquitin viruses such as SCMV, SrMV

replicase viruses such as SCMV, SrMV toxins of Bacillus thuringiensis, VIP 3, Lepidoptera, aphids, mites, nematodes,

Bacilluscereus toxins, Photorabdus and whitefly, beetles such as e.g. the Mexican

Xenorhabdus toxins rice borer 3-hydroxysteroid oxidase Lepidoptera, aphids, mites, nematodes, whitefly, beetles such as e.g. the Mexican rice borer peroxidase Lepidoptera, aphids, mites, nematodes, whitefly, beetles such as e.g. the Mexican rice borer aminopeptidase inhibitors, e.g. leucine Lepidoptera, aphids, mites, nematodes, aminopeptidase inhibitor whitefly, beetles such as e.g. the Mexican rice borer lectins Lepidoptera, aphids, mites, nematodes, whitefly, beetles such as e.g. the Mexican rice borer protease inhibitors, e.g. cystatin, patatin, Lepidoptera, aphids, mites, nematodes, CPTI, virgiferin whitefly, beetles such as e.g. the Mexican rice borer ribosome-inactivating protein Lepidoptera, aphids, mites, nematodes, whitefly, beetles such as e.g. the Mexican rice borer

Feature affected / protein expressed Feature of the plant / tolerance to stilbene synthase Lepidoptera, aphids, mites, nematodes, whitefly, beetles such as e.g. the Mexican rice borer HMG-CoA reductase Lepidoptera, aphids, mites, nematodes, whitefly, beetles such as e.g. the Mexican rice borer hatching factor for cyst nematodes cyst nematodes bamase nematodes, e.g. root-knot nematodes and cyst nematodes CBI root-knot nematodes principles for preventing food uptake nematodes, e.g. root-knot nematodes and induced at nematode feeding sites root-cyst nematodes

Plant: Sunflower

Structure affected / protein expressed Feature of the plant / tolerance to acetolactate synthase (ALS) sulphonylurea compounds, imidazolinones triazolopyrimidines, pyrimidyloxybenzoates, phthalides acetyl-Co A carboxylase (ACCase) aryloxyphenoxyalkanecarboxylic acids, cyclohexanediones hydroxyphenylpyruvate dioxygenase (HPPD) isoxazoles such as, for example, isoxaflutole or isoxachlortole, triones such as, for example, mesotrione or sulcotrione phosphinothricin acetyltransferase phosphinothricin O-methyl transferase modified lignin content glutamine synthetase glufosinate, bialaphos adenylosuccinate lyase (ADSL) inhibitors of IMP and AMP synthesis adenylosuccinate synthase inhibitors of adenylosuccinate synthesis anthranilate synthase inhibitors of tryptophan synthesis and degradation nitrilase 3,5-dihalo-4-hydroxybenzonitriles such as bromoxynil and loxinyl 5-enolpyruvyl-3-phosphoshikimate glyphosate or sulphosate synthase (EPSPS)

Structure affected / protein expressed Feature of the plant / tolerance to glyphosate oxidoreductase glyphosate or sulphosate protoporphyrinogen oxidase (PROTOX) diphenyl ethers, cyclic imides, phenylpyrazoles, pyridine derivatives, phenopylate, oxadiazoles etc. cytochrome P450 e.g. P450 SU1 or selection xenobiotics and herbicides such as, for example, sulphonylurea compounds polyphenol oxidase or polyphenol oxidase bacterial or fungal pathogens (antisense) metallothionein bacterial or fungal pathogens ribonuclease bacterial or fungal pathogens antifungal polypeptid AlyAFP bacterial or fungal pathogens oxalate oxidase bacterial or fungal pathogens, e.g.

Sclerotinia glucose oxidase bacterial or fungal pathogens pyrrolnitrin synthesis genes bacterial or fungal pathogens serine/threonine kinases bacterial or fungal pathogens cecropin B bacterial or fungal pathogens phenylalanine ammonia lyase (PAL) bacterial or fungal pathogens

Cf genes, e.g. Cf 9 Cf5 Cf4 Cf2 bacterial or fungal pathogens osmotin bacterial or fungal pathogens alpha hordothionine bacterial or fungal pathogens systemin bacterial or fungal pathogens polygalacturonase inhibitors bacterial or fungal pathogens

Prf control gene bacterial or fungal pathogens phytoalexins bacterial or fungal pathogens B-l,3-glucanase (antisense) bacterial or fungal pathogens receptor kinase bacterial or fungal pathogens polypeptide having the effect of triggering bacterial or fungal pathogens a hypersensitivity reaction systemic aquired resistance (SAR) genes viral, bacterial, fungal and nematodal pathogens lytic protein bacterial or fungal pathogens lysozyme bacterial or fungal pathogens chitinases bacterial or fungal pathogens bamase bacterial or fungal pathogens

Structure affected/ protein expressed Feature of the plant / tolerance to glucanases bacterial or fungal pathogens

double-strand ribonuclease viruses such as CMV, TMV

envelope proteins viruses such as CMV, TMV

17kDa or 60 kDa protein viruses such as CMV, TMV

nuclear inclusion proteins e.g. a or b or viruses such as CMV, TMV nucleoprotein

pseudoubiquitin viruses such as CMV, TMV

replicase viruses such as CMV, TMV toxins of Bacillus thuringiensis, VIP 3, Lepidoptera, aphids, mites, nematodes,

Bacilluscereus toxins, Photorabdus and whitefly, beetles

Xenorhabdus toxins 3-hydroxysteroid oxidase Lepidoptera, aphids, mites, nematodes, whitefly, beetles peroxidase Lepidoptera, aphids, mites, nematodes, whitefly, beetles aminopeptidase inhibitors, e.g. leucine Lepidoptera, aphids, mites, nematodes, aminopeptidase inhibitor whitefly, beetles lectins Lepidoptera, aphids, mites, nematodes, whitefly, beetles protease inhibitors, e.g. cystatin, patatin, Lepidoptera, aphids, mites, nematodes, CPTI, virgiferin whitefly, beetles ribosome-inactivating protein Lepidoptera, aphids, mites, nematodes, whitefly, beetles stilbene synthase Lepidoptera, aphids, mites, nematodes, whitefly, beetles HMG-CoA reductase Lepidoptera, aphids, mites, nematodes, whitefly, beetles hatching factor for cyst nematodes cyst nematodes bamase nematodes, e.g. root-knot nematodes and cyst nematodes CBI root-knot nematodes principles for preventing food uptake nematodes, e.g. root-knot nematodes and induced at nematode feeding sites root-cyst nematodes

Plants: Sugar beet, turnips

Structure affected / protein expressed Feature of the plant / tolerance to acetolactate synthase (ALS) sulphonylurea compounds, imidazoiinones triazolopyrimidines, pyrimidyloxybenzoates, phthalides acetyl-CoA carboxylase (ACCase) aryloxyphenoxyalkanecarboxylic acids, cyclohexanediones hydroxyphenylpyruvate dioxygenase (HPPD) isoxazoles such as, for example, isoxaflutole or isoxachlortole, triones such as, for example, mesotrione or sulcotrione phosphinothricin acetyltransferase phosphinothricin O-methyl transferase modified lignin content glutamine synthetase glufosinate, bialaphos adenylosuccinate lyase (ADSL) inhibitors of IMP and AMP synthesis adenylosuccinate synthase inhibitors of adenylosuccinate synthesis anthranilate synthase inhibitors of tryptophan synthesis and degradation nitrilase 3,5-dihalo-4-hydroxybenzonitriles such as bromoxynil and loxinyl 5-enolpyruvyl-3-phosphoshikimate glyphosate or sulphosate synthase (EPSPS) glyphosate oxidoreductase glyphosate or sulphosate protoporphyrinogen oxidase (PROTOX) diphenyl ethers, cyclic imides, phenylpyrazoles, pyridine derivatives, phenopylate, oxadiazoles etc. cytochrome P450 e.g. P450 SU1 or selection xenobiotics and herbicides such as, for example, sulphonylurea compounds polyphenol oxidase or polyphenol oxidase bacterial or fungal pathogens (antisense) metallothionein bacterial or fungal pathogens ribonuclease bacterial or fungal pathogens antifungal polypeptid AlyAFP bacterial or fungal pathogens oxalate oxidase bacterial or fungal pathogens, e.g.

Sclerotinia glucose oxidase bacterial or fungal pathogens pyrrolnitrin synthesis genes bacterial or fungal pathogens serine/threonine kinases bacterial or fungal pathogens cecropin B bacterial or fungal pathogens

Structure affected / protein expressed Feature of the plant / tolerance to phenylalanine ammonia lyase (PAL) bacterial or fungal pathogens

Cf genes, e.g. Cf 9 Cf5 Cf4 Cf2 bacterial or fungal pathogens osmotin bacterial or fungal pathogens alpha hordothionine bacterial or fungal pathogens systemin bacterial or fungal pathogens polygalacturonase inhibitors bacterial or fungal pathogens

Prf control gene bacterial or fungal pathogens phytoalexins bacterial or fungal pathogens B-l,3-glucanase (antisense) bacterial or fungal pathogens AX + WIN-proteins bacterial and fungal pathogens such as

Cercospora beticola receptor kinase bacterial or fungal pathogens polypeptide having the effect of triggering bacterial or fungal pathogens a hypersensitivity reaction systemic aquired resistance (SAR) genes viral, bacterial, fungal and nematodal pathogens lytic protein bacterial or fungal pathogens lysozyme bacterial or fungal pathogens chitinases bacterial or fungal pathogens bamase bacterial or fungal pathogens glucanases bacterial or fungal pathogens

double-strand ribonuclease viruses such as, for example, BNYVV

envelope proteins viruses such as, for example, BNYVV

17kDa or 60 kDa protein viruses such as, for example, BNYVV

nuclear inclusion proteins e.g. a or b or viruses such as, for example, BNYVV nucleoprotein

pseudoubiquitin viruses such as, for example, BNYVV

replicase viruses such as, for example, BNYVV toxins of Bacillus thuringiensis, VIP 3, Lepidoptera, aphids, mites, nematodes,

Bacilluscereus toxins, Photorabdus and whitefly, beetles, root-flies

Xenorhabdus toxins 3-hydroxysteroid oxidase Lepidoptera, aphids, mites, nematodes, whitefly, beetles, root-flies peroxidase Lepidoptera, aphids, mites, nematodes, whitefly, beetles, root-flies aminopeptidase inhibitors, e.g. leucine Lepidoptera, aphids, mites, nematodes,

Structure affected / protein expressed Feature of the plant / tolerance to aminopeptidase inhibitor whitefly, beetles, root-flies lectins Lepidoptera, aphids, mites, nematodes, whitefly, beetles, root-flies protease inhibitors, e.g. cystatin, patatin, Lepidoptera, aphids, mites, nematodes, CPU, virgiferin whitefly, beetles, root-flies ribosome-inactivating protein Lepidoptera, aphids, mites, nematodes, whitefly, beetles, root-flies stilbene synthase Lepidoptera, aphids, mites, nematodes, whitefly, beetles, root-flies HMG-CoA reductase Lepidoptera, aphids, mites, nematodes, whitefly, beetles, root-flies hatching factor for cyst nematodes cyst nematodes bamase nematodes, e.g. root-knot nematodes and cyst nematodes beet cyst nematode resistance site cyst nematodes CBI root-knot nematodes principles for preventing food uptake nematodes, e.g. root-knot nematodes and induced root-cyst nematodes

Table 2

In the table, the following abbreviations were used:

active principle of the transgenic plant: AP

Photorhabdus luminescens: PL

Xenorhabdus nematophilus: XN proteinase inhibitors: Plnh. plant lectins PLec. agglutinines: Aggl.

3-hydroxysteroid oxidase: HO cholesterol oxidase: CO chitinase: CH glucanase: GL stilbene synthase: SS

Table 3:

Abbreviations:

acetyl-Co A carboxylase: ACCase acetolactate synthase: ALS hydroxyphenylpyruvate dioxygenase: HPPD inhibition of protein synthesis: IPS hormone imitation: HO glutamine synthetase: GS protoporphyrinogen oxidase: PROTOX 5-enolpyruvy!-3-phosphoshilcimate synthase: EPSPS

*** included are sulphonylurea compounds, imidazolinones, triazolopyrimidines, dimethoxypyrimidines and N-acylsulphonamides: sulphonylurea compounds such as chlorsulfuron, chlorimuron, ethamethsulfuron, metsulfuron, primisulfuron, prosulfuron, triasulfuron, cinosulfuron, trifusulfuron, oxasulfuron, bensulfuron, tribenuron, ACC 322140, fluzasulfuron, ethoxysulfliron, fluzadsulfuron, nicosulfiiron, rimsulfuron, thifensulfuron, pyrazosulfuron, clopyrasulfuron, NC 330, azimsulfuron, imazosulfuron, sulfosulfuron, amidosulfuron, flupyrsulfuron, CGA 362622 imidazolinones such as imazamethabenz, imazaquin, imazamethypyr, imazethapyr, imazapyr and imazamox; triazolopyrimidines such as DE 511, flumetsulam and chloransulam; dimethoxypyrimidines such as, for example, pyrithiobac, pyriminobac, bispyribac and pyribenzoxim. +++ Tolerance to diclofop-methyl, fluazifop-P-buty!, haloxyfop-P-methyl, haloxyfop-P-ethyl, quizalafop-P-ethyl, clodinafop-propargyl, fenoxaprop-ethyl, tepraloxydim, alloxydim, sethoxydim, cycloxydim, cloproxydim, tralkoxydim, butoxydim, caloxydim, clefoxydim, clethodim. &&& chloroacetanilides such as, for example, alachlor, acetochlor, dimethenamid /// Protox inhibitors: for example diphenyl ethers such as, for example, acifluorfen, aclonifen, bifenox, chlomitrofen, ethoxyfen, fluoroglycofen, fomesafen, lactofen, oxyfluorfen; imides such as, for example, azafenidin, carfentrazone-ethyl, cinidon-ethyl, flumiclorac-pentyl, flumioxazin, fluthiacet-methyl, oxadiargyl, oxadiazon, pentoxazone, sulfentrazone, imides and other compounds such as, for example, flumipropyn, flupropacil, nipyraclofen and thidiazimin; and also fluazola and pyraflufen-ethyl.

Table 4

List of examples of transgenic plants having modified properties:

ft

Throughout this specification and the claims which follow, unless the context requires otherwise, the word "comprise", and variations such as "comprises" or "comprising", will be understood to imply the inclusion of a stated integer or step or group of integers or steps but not the exclusion of any other integer or step or group of integers or steps.

The reference in this specification to any prior publication (or information derived from it), or to any matter which is known, is not, and should not be taken as an acknowledgment or admission or any form of suggestion that that prior publication (or information derived from it) or known matter forms part of the common general knowledge in the field of endeavour to which this specification relates.

Claims (17)

1. The claims defining the invention are as follows:

   1. Method for improving the utilization of the production potential of a transgenic plant, the method comprising treating the plant with an effective amount of a mixture of at least one compound of the formula I

   where R1 represents chlorine or cyano and at least one compound of group II, wherein group II comprises imidacloprid, thiodicarb, clothianidin, methiocarb, thiacloprid, thiamethoxam, fipronil, tefluthrin, beta-cyfluthrin, abamectin and spinosad.
2. 2. Method according to Claim 1, wherein the transgenic plant has at least one genetically modified structure or a tolerance according to Table 1.
3. 3. Method according to Claim 1, wherein the transgenic plant has at least one modified principle of action according to Table 3.
4. 4. Method according to Claim 1, wherein the transgenic plant is a transgenic plant according to Table 4.
5. 5. Method according to Claim 1, wherein the transgenic plant comprises at least one genetic modification according to Table 2.
6. 6. Method according to Claim 1, wherein the transgenic plant comprises at least one gene or a gene fragment coding for a Bt toxin.
7. 7. Method according to Claim 1, wherein the transgenic plant is a vegetable plant, maize plant, soya bean plant, cotton plant, tobacco plant, rice plant, sugar beet plant or potato plant.
8. 8. Method according to any one of Claims 1 to 7, wherein the mixture of at least one compound of the formula I and at least one compound of group II is used for controlling insects from the order Isoptera, Thysanoptera, Homoptera, Heteroptera, Lepidoptera, Coleoptera, Hymenoptera or Diptera.
9. 9. Method according to any one of Claims 1 to 8, wherein the application rate of the mixture is between 0.1 g/ha and 5.0 kg/ha.
10. 10. Method according to any one of Claims 1 to 8, wherein the application rate of the mixture is from 0.1 g/ha to 500 g/ha.
11. 11. Method according to any one of Claims 1 to 8, wherein the application rate of the mixture is from 10 g/ha to 500 g/ha.
12. 12. Method according to any one of Claims 1 to 8, wherein the application rate of the mixture is from 10 g/ha to 200 g/ha.
13. 13. Plant parts of transgenic plants obtained following a method according to any of Claims 1 to 12.
14. 14. Plant parts according to Claim 13, wherein the plant parts are seed or propagation material.
15. 15. Plant parts of transgenic plants treated by a method according to any of Claims 1 to 12.
16. 16. Plant parts according to Claim 15, wherein the plant parts are seed or propagation material.
17. 17. Use of a mixture of at least one compound of the formula I

    where R1 represents chlorine or cyano and at least one compound of group II, wherein group II comprises imidacloprid, thiodicarb, clothianidin, methiocarb, thiacloprid, thiamethoxam, fipronil, tefluthrin, beta-cyfluthrin, abamectin and spinosad, in the manufacture of a composition for improving the utilization of the production potential of a transgenic plant.