AU2016213786B2

AU2016213786B2 - Isolated Polynucleotides and Polypeptides, and Methods of Using Same for Increasing Plant Yield and/or Agricultural Characteristics

Info

Publication number: AU2016213786B2
Application number: AU2016213786A
Authority: AU
Inventors: Alex Diber; Eyal Emmanuel; Hagai Karchi; Sarah Rachel Pollock
Original assignee: Evogene Ltd
Current assignee: Evogene Ltd
Priority date: 2009-03-02
Filing date: 2016-08-11
Publication date: 2017-03-30
Anticipated expiration: 2030-03-01
Also published as: AU2017204404B2; AU2017204404A1; AU2018271407B2; AU2016213786A1; AU2018271407A1

Abstract

Provided are isolated polynucleotides which comprise a nucleic acid sequence at least 80% identical to SEQ ID NO: 3487, 1-239, 467-1973, 3481-3486, 3488-3674, 3738 or 3739; isolated polypeptides which comprise an amino acid sequence at least 80% homologous to SEQ ID NO: 246, 240-245, 247-465, 1974-3480, 3675-3736 or 3737, and methods of using same for increasing a yield, biomass, growth rate, vigor, oil content, fiber yield, fiber quality, abiotic stress tolerance, and/or nitrogen use efficiency of a plant.

Description

1 2016213786 11 Aug 2016

ISOLATED POLYNUCLEOTIDES AND POLYPEPTIDES, AND METHODS OF USING SAME FOR INCREASING PLANT YIELD AND/OR AGRICULTURAL

CHARACTERISTICS

5 RELATED APPLICATIONS

This application is a divisional application of Australian Application No. 2015202631, filed on 15 May 2015, which is a divisional of Australian Application No. 2010220157, filed on 1 March 2010, and is related to International Patent Application No. PCT/IB2010/050871, filed on 1 March 2010 and claims priority from U.S. Provisional Patent Application Nos. 10 61/202,459, filed on 2 March 2009, 61/231,349, filed on 5 August 2009 and 61/282,183, filed on 28 December 2009; each of which is incorporated herein by reference in its entirety.

FIELD AND BACKGROUND OF THE INVENTION

The present invention, in some embodiments thereof, relates to isolated polynucleotides 15 and polypeptides which can increase the yield (e.g., biomass, grain quantity and/or quality), growth rate, vigor, abiotic stress tolerance (ABST), water use efficiency (WUE), nitrogen use efficiency (NUE) and/or fertilizer use efficiency (FUE) of a plant.

The ever-increasing world population and the decreasing availability in arable land for agriculture affect the yield of plants and plant-related products. The global shortage of water 20 supply, desertification, abiotic stress (ABS) conditions (e.g., salinity, drought, flood, suboptimal temperature and toxic chemical pollution), and/or limited nitrogen and fertilizer sources cause substantial damage to agricultural plants such as major alterations in the plant metabolism, cell death, and decreases in plant growth and crop productivity.

Drought is a gradual phenomenon, which involves periods of abnormally dry weather 25 that persists long enough to produce serious hydrologic imbalances such as crop damage, water supply shortage and increased susceptibility to various diseases.

Salinity, high salt levels, affects one in five hectares of irrigated land. None of the top five food crops, i. e., wheat, corn, rice, potatoes, and soybean, can tolerate excessive salt. Detrimental effects of salt on plants result from both water deficit, which leads to osmotic stress 30 (similar to drought stress), and the effect of excess sodium ions on critical biochemical processes. As with freezing and drought, high salt causes water deficit; and the presence of high salt makes it difficult for plant roots to extract water from their environment. Thus, salination of soils that are used for agricultural production is a significant and increasing problem in regions that rely heavily on agriculture, and is worsen by over-utilization, 2016213786 11 Aug 2016 5 la over-fertilization and water shortage, typically caused by climatic change and the demands of increasing population.

Suboptimal temperatures affect plant growth and development through the whole plant life cycle. Thus, low temperatures reduce germination rate and high [TEXT CONTINUES ON PAGE 2] 2016213786 11 Aug 2016 2 temperatures result in leaf necrosis. In addition, mature plants that are exposed to excess heat may experience heat shock, which may arise in various organs, including leaves and particularly fruit, when transpiration is insufficient to overcome heat stress. Heat also damages cellular structures, including organelles and cytoskeleton, and impairs 5 membrane function. Heat shock may produce a decrease in overall protein synthesis, accompanied by expression of heat shock proteins, e.g., chaperones, which are involved in refolding proteins denatured by heat. High-temperature damage to pollen almost always occurs in conjunction with drought stress, and rarely occurs under well-watered conditions. Combined stress can alter plant metabolism in novel ways. Excessive 10 chilling conditions, e.g., low, but above freezing, temperatures affect crops of tropical origins, such as soybean, rice, maize, and cotton. Typical chilling damage includes wilting, necrosis, chlorosis or leakage of ions from cell membranes. Excessive light conditions, which occur under clear atmospheric conditions subsequent to cold late summer/autumn night’s, can lead to photoinhibition of photosynthesis (disruption of 15 photosynthesis). In addition, chilling may lead to yield losses and lower product quality through the delayed ripening of maize.

Suboptimal nutrient (macro and micro nutrient) affect plant growth and development through the whole plant life cycle. One of the essential macronutrients for the plant is Nitrogen. Nitrogen is responsible for biosynthesis of amino acids and 20 nucleic acids, prosthetic groups, plant hormones, plant chemical defenses, and the like. Nitrogen is often the rate-limiting element in plant growth and all field crops have a fundamental dependence on inorganic nitrogenous fertilizer. Since fertilizer is rapidly depleted from most soil types, it must be supplied to growing crops two or three times during the growing season. Additional important macronutrients are Phosphorous (P) 25 and Potassium (K), which have a direct correlation to yield and general plant tolerance.

Yield is affected by various factors, such as, the number and size of the plant organs, plant architecture (for example, the number of branches), grains set length, number of filled grains, vigor (e.g. seedling), growth rate, root development, utilization of water, nutrients (e.g., nitrogen) and fertilizers, and stress tolerance. 30 Crops such as, com, rice, wheat, canola and soybean account for over half of total human caloric intake, whether through direct consumption of the seeds themselves or through consumption of meat products raised on processed seeds or forage. Seeds are 2016213786 11 Aug 2016 3 also a source of sugars, oils and metabolites used in industrial processes. The ability to increase plant yield, whether through increase dry matter accumulation rate, modifying cellulose or lignin composition, increase stalk strength, enlarge meristem size, change of plant branching pattern, erectness of levees, increase in fertilization efficiency, 5 enhanced seed dry matter accumulation rate, modification of seed development, enhanced seed filling or by increasing the content of oil, starch or protein in the seeds would have many applications in agricultural and non-agricultural uses such as in the biotechnological production of pharmaceuticals, antibodies or vaccines.

Studies have shown that plant adaptations to adverse environmental conditions 10 are complex genetic traits with polygenic nature. Conventional means for crop and horticultural improvements utilize selective breeding techniques to identify plants having desirable characteristics. However, selective breeding is tedious, time consuming and has an unpredictable outcome. Furthermore, limited germplasm resources for yield improvement and incompatibility in crosses between distantly 15 related plant species represent significant problems encountered in conventional breeding. Advances in genetic engineering have allowed mankind to modify the germplasm of plants by expression of genes-of-interest in plants. Such a technology has the capacity to generate crops or plants with improved economic, agronomic or horticultural traits. 20 WO publication No. 2009/013750 discloses genes, constructs and methods of increasing abiotic stress tolerance, biomass and/or yield in plants generated thereby. WO publication No. 2008/122980 discloses genes constructs and methods for increasing oil content, growth rate and biomass of plants. WO publication No. 2008/075364 discloses polynucleotides involved in plant 25 fiber development and methods of using same. WO publication No. 2007/049275 discloses isolated polypeptides, polynucleotides encoding same, transgenic plants expressing same and methods of using same for increasing plant abiotic stress tolerance and biomass. WO publication No. 2004/104162 discloses methods of increasing abiotic stress 30 tolerance and/or biomass in plants and plants generated thereby. 2016213786 11 Aug 2016 4 WO publication No. 2005/121364 discloses polynucleotides and polypeptides involved in plant fiber development and methods of using same for improving fiber quality, yield and/or biomass of a fiber producing plant. WO publication No. 2007/020638 discloses methods of increasing abiotic stress 5 tolerance and/or biomass in plants and plants generated thereby.

SUMMARY OF THE INVENTION

According to an aspect of some embodiments of the present invention there is provided a method of increasing yield, biomass, growth rate, vigor, oil content, fiber 10 yield, fiber quality, abiotic stress tolerance, and/or nitrogen use efficiency of a plant, comprising expressing within the plant an exogenous polynucleotide comprising a nucleic acid sequence at least 80 % identical to SEQ ID NO: 3487, 1-239, 467-1973, 3481-3486, 3488-3674, 3738 or 3739, thereby increasing the yield, biomass, growth rate, vigor, oil content, fiber yield, fiber quality, abiotic stress tolerance, and/or nitrogen 15 use efficiency of the plant.

According to an aspect of some embodiments of the present invention there is provided a method of increasing yield, biomass, growth rate, vigor, oil content, fiber yield, fiber quality, abiotic stress tolerance, and/or nitrogen use efficiency of a plant, comprising expressing within the plant an exogenous polynucleotide comprising the 20 nucleic acid sequence selected from the group consisting of SEQ ID NOs: 3487, 1-239, 467-1973, 3481-3486, 3488-3674, and 3738-3739, thereby increasing the yield, biomass, growth rate, vigor, oil content, fiber yield, fiber quality, abiotic stress tolerance, and/or nitrogen use efficiency of the plant.

According to an aspect of some embodiments of the present invention there is 25 provided a method of increasing yield, biomass, growth rate, vigor, oil content, fiber yield, fiber quality, abiotic stress tolerance, and/or nitrogen use efficiency of a plant, comprising expressing within the plant an exogenous polynucleotide comprising a nucleic acid sequence encoding a polypeptide at least 80 % identical to SEQ ID NO: 246, 240-245, 247-465, 1974-3480, 3675-3736 or 3737, thereby increasing the yield, 30 biomass, growth rate, vigor, oil content, fiber yield, fiber quality, abiotic stress tolerance, and/or nitrogen use efficiency of the plant. 5

According to an aspect of some embodiments of the present invention there is provided a method of increasing yield, biomass, growth rate, vigor, oil content, fiber yield, fiber quality, abiotic stress tolerance, and/or nitrogen use efficiency of a plant, comprising expressing within the plant an exogenous polynucleotide comprising a nucleic acid sequence encoding a polypeptide selected from the group consisting of SEQ ID NOs: 246, 240-245, 247-465, 1974-3480, and 3675-3737, thereby increasing the yield, biomass, growth rate, vigor, oil content, fiber yield, fiber quality, abiotic stress tolerance, and/or nitrogen use efficiency of the plant.

According to an aspect of some embodiments of the present invention there is provided an isolated polynucleotide comprising a nucleic acid sequence at least 80 % identical to SEQ ID NO: 3487, 1-239, 467-1973, 3481-3486, 3488-3674, 3738 or 3739, wherein said nucleic acid sequence is capable of increasing yield, biomass, growth rate, vigor, oil content, fiber yield, fiber quality, abiotic stress tolerance, and/or nitrogen use efficiency of a plant.

According to an aspect of some embodiments of the present invention there is provided an isolated polynucleotide comprising the nucleic acid sequence selected from the group consisting of SEQ ID NOs: 3487, 1-239, 467-1973, 3481-3486, 3488-3674, and 3738-3739.

According to an aspect of some embodiments of the present invention there is provided an isolated polynucleotide comprising a nucleic acid sequence encoding a polypeptide which comprises an amino acid sequence at least 80 % homologous to the amino acid sequence set forth in SEQ ID NO: 246, 240-245, 247-465, 1974-3480, 3675-3736 or 3737, wherein said nucleic acid sequence is capable of increasing yield, biomass, growth rate, vigor, oil content, fiber yield, fiber quality, abiotic stress tolerance, and/or nitrogen use efficiency of a plant.

According to an aspect of some embodiments of the present invention there is provided an isolated polynucleotide comprising a nucleic acid sequence encoding a polypeptide which comprises the amino acid sequence selected from the group consisting of SEQ ID NOs: 246, 240-245, 247-465, 1974-3480, and 3675-3737.

According to an aspect of some embodiments of the present invention there is provided a nucleic acid construct comprising the isolated polynucleotide of claim 5, 6, 7 2016213786 11 Aug 2016 6 or 8, and a promoter for directing transcription of said nucleic acid sequence in a host cell.

According to an aspect of some embodiments of the present invention there is provided an isolated polypeptide comprising an amino acid sequence at least 80 % 5 homologous to SEQ ID NO: 246, 240-245, 247-465, 1974-3480, 3675-3736 or 3737, wherein said amino acid sequence is capable of increasing yield, biomass, growth rate, vigor, oil content, fiber yield, fiber quality, abiotic stress tolerance, and/or nitrogen use efficiency of a plant.

According to an aspect of some embodiments of the present invention there is 10 provided an isolated polypeptide comprising the amino acid sequence selected from the group consisting of SEQ ID NOs: 246, 240-245, 247-465, 1974-3480, and 3675-3737.

According to an aspect of some embodiments of the present invention there is provided a plant cell exogenously expressing the polynucleotide of claim 5, 6, 7 or 8 or the nucleic acid construct of claim 9. 15 According to an aspect of some embodiments of the present invention there is provided a plant cell exogenously expressing the polypeptide of claim 10 or 11.

According to some embodiments of the invention, the nucleic acid sequence is as set forth in SEQ ID NO: 3487, 1-239, 467-1973, 3481-3486, 3488-3674, 3738 or 3739. 20 According to some embodiments of the invention, the polynucleotide consists of the nucleic acid sequence selected from the group consisting of SEQ ID NOs: 3487, 1-239, 467-1973, 3481-3486, 3488-3674, and 3738-3739.

According to some embodiments of the invention, the nucleic acid sequence encodes an amino acid sequence at least 80 % homologous to SEQ ID NO: 246, 240- 25 245, 247-465, 1974-3480, 3675-3736 or 3737.

According to some embodiments of the invention, the nucleic acid sequence encodes the amino acid sequence selected from the group consisting of SEQ ID NOs: 246, 240-245, 247-465, 1974-3480, and 3675-3737.

According to some embodiments of the invention, the plant cell forms a part of a 30 plant.

According to some embodiments of the invention, the abiotic stress is selected from the group consisting of salinity, drought, water deprivation, low temperature, high 7 2016213786 03 Mar 2017 temperature, heavy metal toxicity, anaerobiosis, nutrient deficiency, nutrient excess, atmospheric pollution and LiV irradiation.

According to some embodiments of the invention, the method further comprises growing the plant, under the abiotic stress. 5 According to some embodiments of the invention, the method, further comprises growing the plant under nitrogen-limiting conditions.

Definitions of the specific embodiments of the invention as claimed herein follow.

According to a first embodiment of the invention, there is provided a method of increasing yield, biomass, growth rate, abiotic stress tolerance, and/or nitrogen use efficiency of 10 a plant, comprising over-expressing within the plant a polypeptide comprising an amino acid sequence at least 80% identical to SEQ ID NO: 322, thereby increasing the yield, biomass, growth rate, abiotic stress tolerance, and/or nitrogen use efficiency of the plant.

According to a second embodiment of the invention, there is provided a method of producing a crop comprising growing a crop plant over-expressing a polypeptide comprising an 15 amino acid sequence at least 80% homologous to the amino acid sequence set forth in SEQ ID NO; 322, wherein the crop plant is derived from plants which over-express said polypeptide as compared to a wild type plant of the same species which is grown under the same growth conditions, and which have been selected for increased yield, increased biomass, increased growth rate, increased abiotic stress tolerance, and/or increased nitrogen use efficiency as 20 compared to said wild type plant of the same species which is grown under the same growth conditions, and the crop plant having the increased yield, increased biomass, increased growth rate, increased abiotic stress tolerance, and/or increased nitrogen use efficiency, thereby producing the crop.

According to a third embodiment of the invention, there is provided a nucleic acid 25 construct comprising an isolated polynucleotide comprising a nucleic acid sequence encoding a polypeptide which comprises an amino acid sequence at least 90% homologous to the amino acid sequence set forth in SEQ ID NO: 322 and a heterologous promoter operably linked to said isolated polynucleotide, wherein said nucleic acid sequence is capable of increasing yield, biomass, growth rate, abiotic stress tolerance, and/or nitrogen use efficiency of a plant. 36 According to a fourth embodiment of the invention, there is provided a nucleic acid construct comprising an isolated polynucleotide comprising a nucleic acid sequence at least 80% identical to SEQ ID NO: 3563 or 85 and a heterologous promoter operably linked to said isolated polynucleotide, wherein said nucleic acid sequence is capable of increasing yield, biomass, growth rate, abiotic stress tolerance, and/or nitrogen use efficiency of a plant. 7a 2016213786 03 Mar 2017

According to a fifth embodiment of the invention, there is provided an isolated polypeptide comprising an amino acid sequence at least 90% homologous to SEQ ID NO: 322, wherein said amino acid sequence is capable of increasing yield, biomass, growth rate, abiotic stress tolerance, and/or nitrogen use efficiency of a plant. 5 According to a sixth embodiment of the invention, there is provided a transgenic plant cell comprising the nucleic acid construct of the third or fourth embodiments.

According to a seventh embodiment of the invention, there is provided a transgenic plant cell exogenously expressing the isolated polypeptide of the fifth embodiment.

According to an eighth embodiment of the invention, there is provided a transgenic plant 10 comprising the cell of the sixth or seventh embodiments, or the nucleic acid construct of the third or fourth embodiments.

According to a ninth embodiment of the invention, there is provided a method of selecting plants having increased yield, biomass, growth rate, abiotic stress tolerance, and/or nitrogen use efficiency, the method comprising selecting plants transformed with the nucleic 15 acid construct of the third or fourth embodiments for an increased trait as compared to a native plant of the same species which is grown under the same growth conditions, wherein said trait is selected from the group consisting of: yield, biomass, growth rate, abiotic stress tolerance, and nitrogen use efficiency.

Unless otherwise defined, all technical and/or scientific terms used herein have the same 20 meaning as commonly understood by one of ordinary skill in the art to which the invention pertains. Although methods and materials similar or equivalent to those described herein can be used in the practice or testing of embodiments of the invention, exemplary methods and/or materials are described below. In case of conflict, the patent specification, including definitions, will control. In addition, the materials, methods, and examples are illustrative only and are not 25 intended to be necessarily limiting.

BRIEF DESCRIPTION OF THE DRAWINGS

Some embodiments of the invention are herein described, by way of example only, with reference to the accompanying drawings. With specific reference now to the drawings in detail, 30 it is stressed that the particulars shown are by way of example and for purposes of illustrative discussion of embodiments of the invention. In this regard, the description taken with the drawings makes apparent to those skilled in the art how embodiments of the invention may be practiced.

In the drawings: 2016213786 03 Mar 2017 7b FIG. 1 is a schematic illustration of the modified pGl binary· plasmid containing the new At6669 promoter (SEQ I D NO:4198) and the GUSintron (pQYN 6669) used for expressing the isolated polynucleotide sequences of the invention. RB - T-DNA right border: LB - T-DNA left border; MCS — Multiple cloning site; RE - any restriction enzyme; NOS pro = nopahne 5 synthase promoter; ΝΡΤ-ΙΓ = neomycin phosphotransferase gene; NOS ter = nopaline. synthase terminator; Poly-A signal (poiyadenylation signal); GUSintron — the GUS reporter gene (coding sequence and iniron). The isolated polynucleotide sequences of the invention were cloned into the vector while replacing the GUSintron reporter gene. 10 [Text continues on page 8.] 7a 2016213786 11 Aug 2016

According to a fourth embodiment of the invention, there is provided a method of producing a crop comprising growing a crop plant transformed with an exogenous polynucleotide comprising a nucleic acid sequence at least 80% identical to SEQ ID NO. 1-6, 8-239, 467-1973, 3481-3486, 3488-3573, 3575-3674, 3738 or 3739, wherein the crop plant is 5 derived from plants which have been transformed with said exogenous polynucleotide and which have been selected tor increased yield, increased biomass, increased growth rate, increased vigor, increased oil content, increased fiber yield, increased fiber quality, increased abiotic stress tolerance, and/or increased nitrogen use efficiency as compared to a wild type plant of the same species which is grown under the same growth conditions, and the crop plant 10 having the increased yield, increased biomass, increased growth rate, increased vigor, increased oil content, increased fiber yield, increased fiber quality, increased abiotic stress tolerance, and/or increased nitrogen use efficiency, thereby producing the crop.

According to a fifth embodiment of the invention, there is provided a nucleic acid construct comprising an isolated polynucleotide comprising a nucleic acid sequence encoding a i 5 polypeptide which comprises an amino acid sequence at least 80% homologous to the amino acid sequence set forth in SEQ ID NO: 240-245, 247-332, 334-465, 1974-3480, 3675-3736 or 373 7 and a heterologous promoter operahly linked to said isolated polynucleotide, wherein said nucleic acid sequence is capable of increasing yield, biomass, growth rate, vigor, oil content, fiber yield, fiber quality, abiotic stress tolerance, and/or nitrogen use efficiency of a plant. 20 According to a sixth embodiment of the invention, there is provided a nucleic acid construct comprising an isolated polynucleotide comprising a nucleic acid sequence at least 80% identical to SEQ ID NO: 1-6, 8-239, 467-1973, 3481-3486, 3488-3573, 3575-3674, 3738 or 3739 and a heterologous promoter operahly linked to said isolated polynucleotide, wherein said nucleic acid sequence is capable of increasing yield, biomass, growth rate, vigor, oil 25 content, fiber yield, fiber quality, abiotic stress tolerance, and/or nitrogen use efficiency of a plant

According to a seventh embodiment of the invention, there is. provided a. isolated polypeptide comprising an amino acid sequence at least 80% homologous to SEQ ID NO: 240-245, 247-332. 334-465, 1974-3480, 3675-3736 or 3737, wherein, said amino acid sequence is 30 capable of increasing yield, biomass, growth rate, vigor, oil content, fiber yield, fiber quality, abiotic stress tolerance, and/or nitrogen use efficiency of a plant.

According to an eighth embodiment of the invention, there is provided a transgenic plant cell comprising the nucleic acid construct of the fifth or sixth embodiments. 7b 2016213786 11 Aug 2016

According to a ninth embodiment of the invention, there is provided a transgenic plant cell exogenously expressing the isolated polypeptide of the seventh embodiment.

According to a tenth embodiment of the invention, there is provided a transgenic plant comprising the cell of the eighth or ninth embodiments, or the nucleic acid construct of the fifth 5 or sixth embodiments.

According to an eleventh embodiment of the invention, there is provided a method of selecting plants having increased yield, biomass, growth rate, vigor, oil content, fiber yield, fiber quality, abiotic stress tolerance, and/or nitrogen use efficiency, the method comprising selecting plants transformed with the nucleic acid construct of the fifth or sixth embodiments 10 for an increased trait as compared to a native plant which is grown under the same growth conditions, said trait is selected from the group consisting of: yield, biomass, growth rate, vigor, oil content, fiber yield, fiber quality, abiotic stress tolerance, and nitrogen use efficiency.

Unless otherwise defined, all technical and/or scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which the invention 15 pertains. Although methods and materials similar or equivalent to those described herein can be used in the practice or testing of embodiments of the invention, exemplary methods and/or materials are described below. In case of conflict, the patent specification, including definitions, will control. In addition, the materials, methods, and examples are illustrative only and are not intended to be necessarily limiting. 20

BRIEF DESCRIPTION OF THE DRAWINGS

Some embodiments of the invention are herein described, by way of example only, with reference to the accompanying drawings. With specific reference now to the drawings in detail, it is stressed that the particulars shown are by way of example and for purposes of illustrative 25 discussion of embodiments of the invention. In this regard, the description taken with the drawings makes apparent to those skilled in the art how embodiments of the invention may be practiced.

In the drawings: FIG. 1 is a schematic illustration of the modified pGI binary plasmid containing the new 30 At6669 promoter (SEQ ID NO:4198) and the GUSintron (pQYN_6669) used for expressing the isolated polynucleotide sequences of the invention. RB - T-DNA right border; LB - T-DNA left border; MCS - Multiple cloning site; RE - any restriction enzyme; NOS pro = nopaline synthase promoter; NPT-II = neomycin phosphotransferase gene; NOS ter = nopaline synthase terminator; Poly-A signal (polyadenylation signal); GUSintron-the GUS reporter gene (coding 2016213786 11 Aug 2016 7c sequence and intron). The isolated polynucleotide sequences of the invention were cloned into the vector while replacing the GUSintron reporter gene.

[Text continues on page 8.] 2016213786 11 Aug 2016 8 FIG. 2 is a schematic illustration of the modified pGI binary plasmid containing the new At6669 promoter (SEQ ID NO:4198) (pQFN) used for expressing the isolated polynucleotide sequences of the invention. RB - T-DNA right border; LB - T-DNA left border; MCS - Multiple cloning site; RE - any restriction enzyme; NOS pro = 5 nopaline synthase promoter; NPT-II = neomycin phosphotransferase gene; NOS ter = nopaline synthase terminator; Poly-A signal (polyadenylation signal); GUSintron - the GUS reporter gene (coding sequence and intron). The isolated polynucleotide sequences of the invention were cloned into the MCS of the vector. FIGs. 3A-F are images depicting visualization of root development of transgenic 10 plants exogenously expressing the polynucleotide of some embodiments of the invention when grown in transparent agar plates under normal (FIGs. 3A-B), osmotic stress (15 % PEG; FIGs. 3C-D) or nitrogen-limiting (FIGs. 3E-F) conditions. The different transgenes were grown in transparent agar plates for 17 days (7 days nursery and 10 days after transplanting). The plates were photographed every 3-4 days starting 15 at day 1 after transplanting. FIG. 3A - An image of a photograph of plants taken following 10 after transplanting days on agar plates when grown under normal (standard) conditions. FIG. 3B - An image of root analysis of the plants shown in FIG. 3A in which the lengths of the roots measured are represented by arrows. FIG. 3C - An image of a photograph of plants taken following 10 days after transplanting on agar 20 plates, grown under high osmotic (PEG 15 %) conditions. FIG. 3D - An image of root analysis of the plants shown in FIG. 3C in which the lengths of the roots measured are represented by arrows. FIG. 3E - An image of a photograph of plants taken following 10 days after transplanting on agar plates, grown under low nitrogen conditions. FIG. 3F - An image of root analysis of the plants shown in FIG. 3E in which the lengths of 25 the roots measured are represented by arrows.

DESCRIPTION OF SPECIFIC EMBODIMENTS OF THE INVENTION

The present invention, in some embodiments thereof, relates to isolated polynucleotides and polypeptides which can increase yield, biomass, growth rate, vigor, 30 oil content, fiber yield, fiber quality abiotic stress tolerance, and/or fertilizer use efficiency (e.g., nitrogen use efficiency) of a plant. 2016213786 11 Aug 2016 9

Before explaining at least one embodiment of the invention in detail, it is to be understood that the invention is not necessarily limited in its application to the details set forth in the following description or exemplified by the Examples. The invention is capable of other embodiments or of being practiced or carried out in various ways. 5 The present inventors have identified novel polynucleotides and polypeptides which can be used in increasing yield, biomass, growth rate, vigor, oil content, fiber yield, fiber quality abiotic stress tolerance, and/or fertilizer use efficiency (e.g., nitrogen use efficiency) of a plant.

As shown in the Examples section which follows, the present inventors have 10 employed a bioinformatic approach which combines clustering and assembly of sequences from databases of arabidopsis, rice, poplar, brachypodium, soybean, grape, castobean, sorghum and maize and other publicly available plant genomes, expressed sequence tags (ESTs), mRNA sequences, properitary ESTs sequences (Barley, Sorghum), protein and pathway databases, quantitative trait loci (QTL), single 15 nucleotide polymorphism (SNPs) information with a digital expression profile (“electronic Northern Blot”) and identified polynucleotides and polypeptides which can increase yield, growth rate, biomass, vigor, tolerance to abiotic stress, nitrogen use efficiency, water use efficiency and fertilizer use efficiency (SEQ ID NOs: 1-239 for polynucleotides; SEQ ID NOs:240-465 for polypeptides; Table 1, Example 1). 20 Orthologs from plant species which exhibit at least 80 % homology to the identified polypeptides and polynucleotides were also identified (SEQ ID NO:467-1973 for polynucleotides; SEQ ID NOs: 1974-3480 for polypeptides; Table 2, Example 1). Selected genes were cloned (Example 7, Tables 26-28), transformed into agrobacterium tumefaciens cells (Example 8) and further into arabidopsis plants (Example 9). 25 Transgenic plants over-expressing the identified polynucleotides were found to exhibit increased seed yield, oil yield, dry weight, fresh weight, root coverage, root length, harvest index, growth rate, rosette area, biomass, oil percentage in seed and weight of 1000 seeds (Examples 10-11; Tables 29-36), and increased tolerance to abiotic stress conditions such as limiting nitrogen conditions (Example 11, Tables 37-38). Thus, the 30 identified polynucleotides and polypeptides of the invention can be used to increase plant’s yield, biomass (e.g., of grain or any harvestable plant part with economical 2016213786 11 Aug 2016 10 value), vigor, growth rate, oil content, fiber yield, fiber quality, tolerance to abiotic stress, nitrogen use efficiency, water use efficiency and/or fertilizer use efficiency.

Thus, according to an aspect of some embodiments of the invention there is provided a method of increasing a yield, biomass, growth rate, vigor, oil content, fiber 5 yield, fiber quality, water use efficiency, nitrogen use efficiency, fertilizer use efficiency and/or abiotic stress tolerance of a plant.

The method is effected by expressing within the plant an exogenous polynucleotide comprising a nucleic acid sequence at least 80 % identical to SEQ ID NO: 3487, 1-239, 467-1973, 3481-3486, 3488-3674, 3738 or 3739, thereby increasing 10 the yield, biomass, growth rate, vigor, oil content, fiber yield, fiber quality, water use efficiency, nitrogen use efficiency, fertilizer use efficiency and/or abiotic stress tolerance of the plant.

As used herein the phrase "plant yield" refers to the amount (e.g., as determined by weight or size) or quantity (numbers) of tissues or organs produced per plant or per 15 growing season. Hence increased yield could affect the economic benefit one can obtain from the plant in a certain growing area and/or growing time.

It should be noted that a plant yield can be affected by various parameters including, but not limited to, plant biomass; plant vigor; growth rate; seed yield; seed or grain quantity; seed or grain quality; oil yield; content of oil, starch and/or protein in 20 harvested organs (e.g., seeds or vegetative parts of the plant); number of flowers (florets) per panicle (expressed as a ratio of number of filled seeds over number of primary panicles); harvest index; number of plants grown per area; number and size of harvested organs per plant and per area; number of plants per growing area (density); number of harvested organs in field; total leaf area; carbon assimilation and carbon partitioning (the 25 distribution/allocation of carbon within the plant); resistance to shade; number of harvestable organs (e.g. seeds), seeds per pod, weight per seed; and modified architecture [such as increase stalk diameter, thickness or improvement of physical properties (e.g. elasticity)] .

As used herein the phrase “seed yield” refers to the number or weight of the 30 seeds per plant, seeds per pod, or per growing area or to the weight of a single seed, or to the oil extracted per seed. Hence seed yield can be affected by seed dimensions (e.g., length, width, perimeter, area and/or volume), number of (filled) seeds and seed filling 11 rate and by seed oil content. Hence increase seed yield per plant could affect the economic benefit one can obtain from the plant in a certain growing area and/or growing time; and increase seed yield per growing area could be achieved by increasing seed yield per plant, and/or by increasing number of plants grown on the same given area.

The term "seed" (also referred to as "grain" or "kernel") as used herein refers to a small embryonic plant enclosed in a covering called the seed coat (usually with some stored food), the product of the ripened ovule of gymnosperm and angiosperm plants which occurs after fertilization and some growth within the mother plant.

The phrase “oil content” as used herein refers to the amount of lipids in a given plant organ, either the seeds (seed oil content) or the vegetative portion of the plant (vegetative oil content) and is typically expressed as percentage of dry weight (10 % humidity of seeds) or wet weight (for vegetative portion).

It should be noted that oil content is affected by intrinsic oil production of a tissue (e.g., seed, vegetative portion), as well as the mass or size of the oil-producing tissue per plant or per growth period.

In one embodiment, increase in oil content of the plant can be achieved by increasing the size/mass of a plant's tissue(s) which comprise oil per growth period. Thus, increased oil content of a plant can be achieved by increasing the yield, growth rate, biomass and vigor of the plant.

As used herein the phrase "plant biomass" refers to the amount (e.g., measured in grams of air-dry tissue) of a tissue produced from the plant in a growing season, which could also determine or affect the plant yield or the yield per growing area. An increase in plant biomass can be in the whole plant or in parts thereof such as aboveground (harvestable) parts, vegetative biomass, roots and seeds.

As used herein the phrase “growth rate” refers to the increase in plant organ/tissue size per time (can be measured in cm2 per day).

As used herein the phrase "plant vigor" refers to the amount (measured by weight) of tissue produced by the plant in a given time. Hence increased vigor could determine or affect the plant yield or the yield per growing time or growing area. In addition, early vigor (seed and/or seedling) results in improved field stand.

It should be noted that a plant yield can be determined under stress (e.g., abiotic stress, nitrogen-limiting conditions) and/or non-stress (normal) conditions. 2016213786 11 Aug 2016 12

As used herein, the phrase “non-stress conditions” refers to the growth conditions (e.g., water, temperature, light-dark cycles, humidity, salt concentration, fertilizer concentration in soil, nutrient supply such as nitrogen, phosphorous and/or potassium), that do not significantly go beyond the everyday climatic and other abiotic 5 conditions that plants may encounter, and which allow optimal growth, metabolism, reproduction and/or viability of a plant at any stage in its life cycle (e.g., in a crop plant from seed to a mature plant and back to seed again). Persons skilled in the art are aware of normal soil conditions and climatic conditions for a given plant in a given geographic location. It should be noted that while the non-stress conditions may include some mild 10 variations from the optimal conditions (which vary from one type/species of a plant to another), such variations do not cause the plant to cease growing without the capacity to resume growth.

The phrase "abiotic stress" as used herein refers to any adverse effect on metabolism, growth, reproduction and/or viability of a plant. Accordingly, abiotic stress 15 can be induced by suboptimal environmental growth conditions such as, for example, salinity, water deprivation, flooding, freezing, low or high temperature, heavy metal toxicity, anaerobiosis, nutrient deficiency, atmospheric pollution or UV irradiation. The implications of abiotic stress are discussed in the Background section.

The phrase “abiotic stress tolerance” as used herein refers to the ability of a plant 20 to endure an abiotic stress without suffering a substantial alteration in metabolism, growth, productivity and/or viability.

As used herein the phrase “water use efficiency (WUE)” refers to the level of organic matter produced per unit of water consumed by the plant, i.e., the dry weight of a plant in relation to the plant's water use, e.g., the biomass produced per unit 25 transpiration.

As used herein the phrase “fertilizer use efficiency” refers to the metabolic process(es) which lead to an increase in the plant’s yield, biomass, vigor, and growth rate per fertilizer unit applied. The metabolic process can be the uptake, spread, absorbent, accumulation, relocation (within the plant) and use of one or more of the 30 minerals and organic moieties absorbed by the plant, such as nitrogen, phosphates and/or potassium. 2016213786 11 Aug 2016 13

As used herein the phrase “fertilizer-limiting conditions” refers to growth conditions which include a level (e.g., concentration) of a fertilizer applied which is below the level needed for normal plant metabolism, growth, reproduction and/or viability. 5 As used herein the phrase “nitrogen use efficiency (NUE)” refers to the metabolic process(es) which lead to an increase in the plant’s yield, biomass, vigor, and growth rate per nitrogen unit applied. The metabolic process can be the uptake, spread, absorbent, accumulation, relocation (within the plant) and use of nitrogen absorbed by the plant. 10 As used herein the phrase “nitrogen-limiting conditions” refers to growth conditions which include a level (e.g., concentration) of nitrogen (e.g., ammonium or nitrate) applied which is below the level needed for normal plant metabolism, growth, reproduction and/or viability.

Improved plant NUE and FUE is translated in the field into either harvesting 15 similar quantities of yield, while implementing less fertilizers, or increased yields gained by implementing the same levels of fertilizers. Thus, improved NUE or FUE has a direct effect on plant yield in the field. Thus, the polynucleotides and polypeptides of some embodiments of the invention positively affect plant yield, seed yield, and plant biomass. In addition, the benefit of improved plant NUE will certainly improve crop 20 quality and biochemical constituents of the seed such as protein yield and oil yield.

It should be noted that improved ABST will confer plants with improved vigor also under non-stress conditions, resulting in crops having improved biomass and/or yield e.g., elongated fibers for the cotton industry, higher oil content.

The term "fiber" is usually inclusive of thick-walled conducting cells such as 25 vessels and tracheids and to fibrillar aggregates of many individual fiber cells. Hence, the term "fiber" refers to (a) thick-walled conducting and non-conducting cells of the xylem; (b) fibers of extraxylary origin, including those from phloem, bark, ground tissue, and epidermis; and (c) fibers from stems, leaves, roots, seeds, and flowers or inflorescences (such as those of Sorghum vulgare used in the manufacture of brushes 30 and brooms).

As used herein the phrase "fiber producing plant" refers to plants that share the common feature of having an elongated shape and abundant cellulose in thick cell 2016213786 11 Aug 2016 14 walls, typically termed as secondary walls. Such walls may or may not be lignified, and the protoplast of such cells may or may be viable at maturity. Such fibers have many industrial uses, for example in lumber and manufactured wood products, paper, textiles, sacking and boxing material, cordage, brushes and brooms, filling and stuffing, 5 caulking, reinforcement of other materials, and manufacture of cellulose derivatives.

Example of fiber producing plants, include, but are not limited to, agricultural crops such as cotton, silk cotton tree (Kapok, Ceiba pentandra), desert willow, creosote bush, winterfat, balsa, kenaf, roselle, jute, sisal abaca, flax, com, sugar cane, hemp, ramie, kapok, coir, bamboo, Spanish moss and Agave spp. (e.g. sisal). 10 According to a preferred embodiment of this aspect of the present invention the fiber producing plant is cotton.

As used herein the phrase "fiber quality" refers to at least one fiber parameter which is agriculturally desired, or required in the fiber industry (further described hereinbelow). Examples of such parameters, include but are not limited to, fiber length, 15 fiber strength, fiber fitness, fiber weight per unit length, maturity ratio and uniformity.

Cotton fiber (lint) quality is typically measured according to fiber length, strength and fineness. Accordingly, the lint quality is considered higher when the fiber is longer, stronger and finer.

As used herein the phrase "fiber yield" refers to the amount or quantity of fibers 20 produced from the fiber producing plant.

As used herein the term "increasing" refers to at least about 2 %, at least about 3 %, at least about 4 %, at least about 5 %, at least about 10 %, at least about 15 %, at least about 20 %, at least about 30 %, at least about 40 %, at least about 50 %, at least about 60 %, at least about 70 %, at least about 80 % or greater increase in plant yield, 25 biomass, growth rate, vigor, oil content, fiber yield, fiber quality, water use efficiency, nitrogen use efficiency, fertilizer use efficiency and/or abiotic stress tolerance as compared to a native plant [L e., a plant not modified with the biomolecules (polynucleotide or polypeptides) of the invention, e.g., a non-transformed plant of the same species which is grown under the same growth conditions as the transformed 30 plant].

The phrase “expressing within the plant an exogenous polynucleotide” as used herein refers to upregulating the expression level of an exogenous polynucleotide within 2016213786 11 Aug 2016 15 the plant by introducing the exogenous polynucleotide into a plant cell or plant and expressing by recombinant means, as further described herein below.

As used herein "expressing" refers to expression at the mRNA and optionally polypeptide level. 5 As used herein, the phrase "exogenous polynucleotide" refers to a heterologous nucleic acid sequence which may not be naturally expressed within the plant or which overexpression in the plant is desired. The exogenous polynucleotide may be introduced into the plant in a stable or transient manner, so as to produce a ribonucleic acid (RNA) molecule and/or a polypeptide molecule. It should be noted that the exogenous 10 polynucleotide may comprise a nucleic acid sequence which is identical or partially homologous to an endogenous nucleic acid sequence of the plant.

The term “endogenous” as used herein refers to any polynucleotide or polypeptide which is present and/or naturally expressed within a plant or a cell thereof.

According to some embodiments of the invention, the exogenous polynucleotide 15 comprises a nucleic acid which is at least about 80 %, at least about 81 %, at least about 82 %, at least about 83 %, at least about 84 %, at least about 85 %, at least about 86 %, at least about 87 %, at least about 88 %, at least about 89 %, at least about 90 %, at least about 91 %, at least about 92 %, at least about 93 %, at least about 93 %, at least about 94 %, at least about 95 %, at least about 96 %, at least about 97 %, at least about 98 %, 20 at least about 99 %, e.g., 100 % identical to the nucleic acid sequence selected from the group consisting of SEQ ID NOs: 3487, 1-239, 467-1973, 3481-3486, 3488-3674, and 3738-3739.

Identity (e.g., percent homology) can be determined using any homology comparison software, including for example, the BlastN software of the National Center 25 of Biotechnology Information (NCBI) such as by using default parameters.

According to some embodiments of the invention the exogenous polynucleotide is at least about 80 %, at least about 81 %, at least about 82 %, at least about 83 %, at least about 84 %, at least about 85 %, at least about 86 %, at least about 87 %, at least about 88 %, at least about 89 %, at least about 90 %, at least about 91 %, at least about 30 92 %, at least about 93 %, at least about 93 %, at least about 94 %, at least about 95 %, at least about 96 %, at least about 97 %, at least about 98 %, at least about 99 %, e.g., 2016213786 11 Aug 2016 16 100 % identical to the polynucleotide selected from the group consisting of SEQ ID NOs: 3487, 1-239, 467-1973, 3481-3486, 3488-3674, and 3738-3739.

According to some embodiments of the invention the exogenous polynucleotide consists of the nucleic acid sequence set forth in SEQ ID NO: 3487, 1-239, 467-1973, 5 3481-3486, 3488-3674, 3738 or 3739.

As used herein the term “polynucleotide” refers to a single or double stranded nucleic acid sequence which is isolated and provided in the form of an RNA sequence, a complementary polynucleotide sequence (cDNA), a genomic polynucleotide sequence and/or a composite polynucleotide sequences (e.g., a combination of the above). 10 The term “isolated” refers to at least partially separated from the natural environment e.g., from a plant cell.

As used herein the phrase "complementary polynucleotide sequence" refers to a sequence, which results from reverse transcription of messenger RNA using a reverse transcriptase or any other RNA dependent DNA polymerase. Such a sequence can be 15 subsequently amplified in vivo or in vitro using a DNA dependent DNA polymerase.

As used herein the phrase "genomic polynucleotide sequence" refers to a sequence derived (isolated) from a chromosome and thus it represents a contiguous portion of a chromosome.

As used herein the phrase "composite polynucleotide sequence" refers to a 20 sequence, which is at least partially complementary and at least partially genomic. A composite sequence can include some exonal sequences required to encode the polypeptide of the present invention, as well as some intronic sequences interposing therebetween. The intronic sequences can be of any source, including of other genes, and typically will include conserved splicing signal sequences. Such intronic sequences 25 may further include cis acting expression regulatory elements.

According to some embodiments of the invention, the exogenous polynucleotide of the invention encodes a polypeptide which comprises an amino acid sequence at least about 80 %, at least about 81 %, at least about 82 %, at least about 83 %, at least about 84 %, at least about 85 %, at least about 86 %, at least about 87 %, at least about 88 %, 30 at least about 89 %, at least about 90 %, at least about 91 %, at least about 92 %, at least about 93 %, at least about 94 %, at least about 95 %, at least about 96 %, at least about 97 %, at least about 98 %, at least about 99 %, or more say 100 % homologous to the 2016213786 11 Aug 2016 17 amino acid sequence selected from the group consisting of SEQ ID NOs: 246, 240-245, 247-465, 1974-3480, and 3675-3737.

Homology (e.g., percent homology) can be determined using any homology comparison software, including for example, the BlastP or TBLASTN software of the 5 National Center of Biotechnology Information (NCBI) such as by using default parameters, when starting from a polypeptide sequence; or the tBLASTX algorithm (available via the NCBI) such as by using default parameters, which compares the six-frame conceptual translation products of a nucleotide query sequence (both strands) against a protein sequence database. 10 Homologous sequences include both orthologous and paralogous sequences.

The term “paralogous” relates to gene-duplications within the genome of a species leading to paralogous genes. The term “orthologous” relates to homologous genes in different organisms due to ancestral relationship.

One option to identify orthologues in plant species is by performing a reciprocal 15 blast search. This may be done by a first blast involving blasting the sequence-of-interest against any sequence database, such as the publicly available NCBI database which may be found at: Hypertext Transfer Protocol ://World Wide Web (dot) ncbi (dot) nlm (dot) nih (dot) gov. If orthologues in rice were sought, the sequence-of-interest would be blasted against, for example, the 28,469 full-length cDNA clones from Oryza sativa 20 Nipponbare available at NCBI. The blast results may be filtered. The full-length sequences of either the filtered results or the non-filtered results are then blasted back (second blast) against the sequences of the organism from which the sequence-of-interest is derived. The results of the first and second blasts are then compared. An orthologue is identified when the sequence resulting in the highest score (best hit) in the 25 first blast identifies in the second blast the query sequence (the original sequence-of-interest) as the best hit. Using the same rational a paralogue (homolog to a gene in the same organism) is found. In case of large sequence families, the ClustalW program may be used [Hypertext Transfer Protocol ://World Wide Web (dot) ebi (dot) ac (dot) uk/Tools/clustalw2/index (dot) html], followed by a neighbor-joining tree (Hypertext 30 Transfer Protocol://en (dot) wikipedia (dot) org/wiki/Neighbor-joining) which helps visualizing the clustering. 2016213786 11 Aug 2016 18

According to some embodiments of the invention, the exogenous polynucleotide encodes a polypeptide consisting of the amino acid sequence set forth by SEQ ID NO: 246, 240-245, 247-465, 1974-3480, 3675-3736 or 3737.

Nucleic acid sequences encoding the polypeptides of the present invention may 5 be optimized for expression. Examples of such sequence modifications include, but are not limited to, an altered G/C content to more closely approach that typically found in the plant species of interest, and the removal of codons atypically found in the plant species commonly referred to as codon optimization.

The phrase "codon optimization" refers to the selection of appropriate DNA 10 nucleotides for use within a structural gene or fragment thereof that approaches codon usage within the plant of interest. Therefore, an optimized gene or nucleic acid sequence refers to a gene in which the nucleotide sequence of a native or naturally occurring gene has been modified in order to utilize statistically-preferred or statistically-favored codons within the plant. The nucleotide sequence typically is 15 examined at the DNA level and the coding region optimized for expression in the plant species determined using any suitable procedure, for example as described in Sardana et al. (1996, Plant Cell Reports 15:677-681). In this method, the standard deviation of codon usage, a measure of codon usage bias, may be calculated by first finding the squared proportional deviation of usage of each codon of the native gene relative to that 20 of highly expressed plant genes, followed by a calculation of the average squared deviation. The formula used is:

Formula I 1 SDCU = n = 1 N [ ( Xn - Yn ) / Yn ] 2 / N, where Xn refers to the frequency of usage of codon n in highly expressed plant 25 genes, where Yn to the frequency of usage of codon n in the gene of interest and N refers to the total number of codons in the gene of interest. A Table of codon usage from highly expressed genes of dicotyledonous plants is compiled using the data of Murray et al. (1989, Nuc Acids Res. 17:477-498).

One method of optimizing the nucleic acid sequence in accordance with the 30 preferred codon usage for a particular plant cell type is based on the direct use, without performing any extra statistical calculations, of codon optimization Tables such as those provided on-line at the Codon Usage Database through the NIAS (National Institute of 2016213786 11 Aug 2016 19

Agrobiological Sciences) DNA bank in Japan (Hypertext Transfer Protocol://World Wide Web (dot) kazusa (dot) or (dot) jp/codon/). The Codon Usage Database contains codon usage tables for a number of different species, with each codon usage Table having been statistically determined based on the data present in Genbank. 5 By using the above Tables to determine the most preferred or most favored codons for each amino acid in a particular species (for example, rice), a naturally-occurring nucleotide sequence encoding a protein of interest can be codon optimized for that particular plant species. This is effected by replacing codons that may have a low statistical incidence in the particular species genome with corresponding codons, in 10 regard to an amino acid, that are statistically more favored. However, one or more less-favored codons may be selected to delete existing restriction sites, to create new ones at potentially useful junctions (5' and 3' ends to add signal peptide or termination cassettes, internal sites that might be used to cut and splice segments together to produce a correct full-length sequence), or to eliminate nucleotide sequences that may negatively effect 15 mRNA stability or expression.

The naturally-occurring encoding nucleotide sequence may already, in advance of any modification, contain a number of codons that correspond to a statistically-favored codon in a particular plant species. Therefore, codon optimization of the native nucleotide sequence may comprise determining which codons, within the native 20 nucleotide sequence, are not statistically-favored with regards to a particular plant, and modifying these codons in accordance with a codon usage table of the particular plant to produce a codon optimized derivative. A modified nucleotide sequence may be fully or partially optimized for plant codon usage provided that the protein encoded by the modified nucleotide sequence is produced at a level higher than the protein encoded by 25 the corresponding naturally occurring or native gene. Construction of synthetic genes by altering the codon usage is described in for example PCT Patent Application 93/07278.

According to some embodiments of the invention, the exogenous polynucleotide is a non-coding RNA. 30 As used herein the phrase ‘non-coding RNA” refers to an RNA molecule which does not encode an amino acid sequence (a polypeptide). Examples of such non-coding 2016213786 11 Aug 2016 20 RNA molecules include, but are not limited to, an antisense RNA, a pre-miRNA (precursor of a microRNA), or a precursor of a Piwi-interacting RNA (piRNA).

Non-limiting examples of non-coding RNA polynucleotides are provided in SEQ ID NOs:37 and 43. 5 Thus, the invention encompasses nucleic acid sequences described hereinabove; fragments thereof, sequences hybridizable therewith, sequences homologous thereto, sequences encoding similar polypeptides with different codon usage, altered sequences characterized by mutations, such as deletion, insertion or substitution of one or more nucleotides, either naturally occurring or man induced, either randomly or in a targeted 10 fashion.

The invention provides an isolated polynucleotide comprising a nucleic acid sequence which is at least about 80 %, at least about 81 %, at least about 82 %, at least about 83 %, at least about 84 %, at least about 85 %, at least about 86 %, at least about 87 %, at least about 88 %, at least about 89 %, at least about 90 %, at least about 91 %, 15 at least about 92 %, at least about 93 %, at least about 93 %, at least about 94 %, at least about 95 %, at least about 96 %, at least about 97 %, at least about 98 %, at least about 99 %, e.g., 100 % identical to the polynucleotide selected from the group consisting of SEQ ID NOs: 3487, 1-239, 467-1973, 3481-3486, 3488-3674, and 3738-3739.

According to some embodiments of the invention the nucleic acid sequence is 20 capable of increasing yield, biomass, growth rate, vigor, oil content, fiber yield, fiber quality, water use efficiency, nitrogen use efficiency, fertilizer use efficiency and/or abiotic stress tolerance of a plant.

According to some embodiments of the invention the isolated polynucleotide consists of a nucleic acid sequence which is at least about 80 %, at least about 81 %, at 25 least about 82 %, at least about 83 %, at least about 84 %, at least about 85 %, at least about 86 %, at least about 87 %, at least about 88 %, at least about 89 %, at least about 90 %, at least about 91 %, at least about 92 %, at least about 93 %, at least about 93 %, at least about 94 %, at least about 95 %, at least about 96 %, at least about 97 %, at least about 98 %, at least about 99 %, e.g., 100 % identical to the polynucleotide selected 30 from the group consisting of SEQ ID NOs: 3487, 1-239, 467-1973, 3481-3486, 3488-3674, and 3738-3739. 2016213786 11 Aug 2016 21

According to some embodiments of the invention the isolated polynucleotide comprising the nucleic acid sequence selected from the group consisting of SEQ ID NOs: 3487, 1-239, 467-1973, 3481-3486, 3488-3674, and 3738-3739.

According to some embodiments of the invention the isolated polynucleotide is 5 set forth by SEQ ID NO: 3487, 1-239, 467-1973, 3481-3486, 3488-3674, 3738 or 3739.

According to some embodiments of the invention the isolated polynucleotide consists of a nucleic acid sequence selected from the group of SEQ ID NOs: 3487, 1-239, 467-1973, 3481-3486, 3488-3674, and 3738-3739.

The invention provides an isolated polynucleotide comprising a nucleic acid 10 sequence encoding a polypeptide which comprises an amino acid sequence at least about 80 %, at least about 81 %, at least about 82 %, at least about 83 %, at least about 84 %, at least about 85 %, at least about 86 %, at least about 87 %, at least about 88 %, at least about 89 %, at least about 90 %, at least about 91 %, at least about 92 %, at least about 93 %, at least about 93 %, at least about 94 %, at least about 95 %, at least about 15 96 %, at least about 97 %, at least about 98 %, at least about 99 %, or more say 100 % homologous to the amino acid sequence selected from the group consisting of SEQ ID NO: 246, 240-245, 247-465, 1974-3480, and 3675-3737.

According to some embodiments of the invention the amino acid sequence is capable of increasing yield, biomass, growth rate, vigor, oil content, fiber yield, fiber 20 quality, water use efficiency, nitrogen use efficiency, fertilizer use efficiency and/or abiotic stress tolerance of a plant.

The invention provides an isolated polynucleotide comprising a nucleic acid sequence encoding a polypeptide which comprises the amino acid sequence selected from the group consisting of SEQ ID NOs: 246, 240-245, 247-465, 1974-3480, and 25 3675-3737.

The invention provides an isolated polypeptide having an amino acid sequence at least about 80 %, at least about 81 %, at least about 82 %, at least about 83 %, at least about 84 %, at least about 85 %, at least about 86 %, at least about 87 %, at least about 88 %, at least about 89 %, at least about 90 %, at least about 91 %, at least about 92 %, 30 at least about 93 %, at least about 93 %, at least about 94 %, at least about 95 %, at least about 96 %, at least about 97 %, at least about 98 %, at least about 99 %, or more say 2016213786 11 Aug 2016 22 100 % homologous to an amino acid sequence selected from the group consisting of SEQ ID NOs: 246, 240-245, 247-465, 1974-3480, and 3675-3737.

According to some embodiments of the invention, the isolated polypeptide is selected from the group consisting of SEQ ID NOs: 246, 240-245, 247-465, 1974-3480, 5 and 3675-3737.

The invention also encompasses fragments of the above described polypeptides and polypeptides having mutations, such as deletions, insertions or substitutions of one or more amino acids, either naturally occurring or man induced, either randomly or in a targeted fashion. 10 The term '"plant" as used herein encompasses whole plants, ancestors and progeny of the plants and plant parts, including seeds, shoots, stems, roots (including tubers), and plant cells, tissues and organs. The plant may be in any form including suspension cultures, embryos, meristematic regions, callus tissue, leaves, gametophytes, sporophytes, pollen, and microspores. Plants that are particularly useful in the methods 15 of the invention include all plants which belong to the superfamily Viridiplantae, in particular monocotyledonous and dicotyledonous plants including a fodder or forage legume, ornamental plant, food crop, tree, or shrub selected from the list comprising Acacia spp., Acer spp., Actinidia spp., Aesculus spp., Agathis australis, Albizia amara, Alsophila tricolor, Andropogon spp., Arachis spp, Areca catechu, Astelia fragrans, 20 Astragalus cicer, Baikiaea plurijuga, Betula spp., Brassica spp., Bruguiera gymnorrhiza, Burkea africana, Butea frondosa, Cadaba farinosa, Calliandra spp, Camellia sinensis, Canna indica, Capsicum spp., Cassia spp., Centroema pubescens, Chacoomeles spp., Cinnamomum cassia, Coffea arabica, Colophospermum mopane, Coronillia varia, Cotoneaster serotina, Crataegus spp., Cucumis spp., Cupressus spp., Cyathea dealbata, 25 Cydonia oblonga, Cryptomcria japonica, Cymbopogon spp., Cynthea dealbata, Cydonia oblonga, Dalbergia monetaria, Davallia divaricata, Desmodium spp., Dicksonia squarosa, Dibeteropogon amplectens, Dioclea spp, Dolichos spp., Dorycnium rectum, Echinochloa pyramidalis, Ehraffia spp., Eleusine coracana, Eragrestis spp., Erythrina spp., Eucalyptus spp., Euclea schimperi, Eulalia vi/losa, Pagopyrum spp., Feijoa 30 sellowlana, Fragaria spp., Flemingia spp, Freycinetia banksli, Geranium thunbergii, GinAgo biloba, Glycine javanica, Gliricidia spp, Gossypium hirsutum, Grevillea spp., Guibourtia coleosperma, Hedysarum spp., Hemaffhia altissima, Heteropogon contoffus, 23

Hordeum vulgare, Hyparrhenia rufa, Hypericum erectum, Hypeffhelia dissolute, Indigo incamata, Iris spp., Leptarrhena pyrolifolia, Lespediza spp., Lettuca spp., Leucaena leucocephala, Loudetia simplex, Lotonus bainesli, Lotus spp., Macrotyloma axillare, Malus spp., Manihot esculenta, Medicago saliva, Metasequoia glyptostroboides, Musa sapientum, Nicotianum spp., Onobrychis spp., Omithopus spp., Oryza spp., Peltophorum airicanum, Pennisetum spp., Persea gratissima, Petunia spp., Phaseolus spp., Phoenix canariensis, Phormium cookianum, Photinia spp., Picea glauca, Pinus spp., Pisum sativam, Podocarpus totara, Pogonarthria fleckii, Pogonaffhria squarrosa, Populus spp., Prosopis cineraria, Pseudotsuga menziesii, Pterolobium stellatum, Pyrus communis, Quercus spp., Rhaphiolepsis umbellata, Rhopalostylis sapida, Rhus natalensis, Ribes grossularia, Ribes spp., Robinia pseudoacacia, Rosa spp., Rubus spp., Salix spp., Schyzachyrium sanguineum, Sciadopitys vcfficillata, Sequoia sempervirens, Sequoiadendron giganteum, Sorghum bicolor, Spinacia spp., Sporobolus fimbriatus, Stiburus alopecuroides, Stylosanthos humilis, Tadehagi spp, Taxodium distichum, Themeda triandra, Trifolium spp., Triticum spp., Tsuga heterophylla, Vaccinium spp., Vicia spp., Vitis vinifera, Watsonia pyramidata, Zantedeschia aethiopica, Zea mays, amaranth, artichoke, asparagus, broccoli, Brussels sprouts, cabbage, canola, carrot, cauliflower, celery, collard greens, flax, kale, lentil, oilseed rape, okra, onion, potato, rice, soybean, straw, sugar beet, sugar cane, sunflower, tomato, squash tea, maize, wheat, barely, rye, oat, peanut, pea, lentil and alfalfa, cotton, rapeseed, canola, pepper, sunflower, tobacco, eggplant, eucalyptus, a tree, an ornamental plant, a perennial grass and a forage crop. Alternatively algae and other non-Viridiplantae can be used for the methods of the present invention.

According to some embodiments of the invention, the plant used by the method of the invention is a crop plant such as rice, maize, wheat, barley, peanut, potato, sesame, olive tree, palm oil, banana, soybean, sunflower, canola, sugarcane, alfalfa, millet, leguminosae (bean, pea), flax, lupinus, rapeseed, tobacco, poplar, cotton and sorghum.

According to some embodiments of the invention, there is provided a plant cell exogenously expressing the polynucleotide of some embodiments of the invention, the nucleic acid construct of some embodiments of the invention and/or the polypeptide of some embodiments of the invention. 2016213786 11 Aug 2016 24

According to some embodiments of the invention, expressing the exogenous polynucleotide of the invention within the plant is effected by transforming one or more cells of the plant with the exogenous polynucleotide, followed by generating a mature plant from the transformed cells and cultivating the mature plant under conditions 5 suitable for expressing the exogenous polynucleotide within the mature plant.

According to some embodiments of the invention, the transformation is effected by introducing to the plant cell a nucleic acid construct which includes the exogenous polynucleotide of some embodiments of the invention and at least one promoter capable of directing transcription of the exogenous polynucleotide in the plant cell. Further 10 details of suitable transformation approaches are provided herein below.

According to some embodiments of the invention, there is provided a nucleic acid construct comprising the isolated polynucleotide of the invention, and a promoter for directing transcription of the nucleic acid sequence of the isolated polynucleotide in a host cell. 15 According to some embodiments of the invention, the isolated polynucleotide is operably linked to the promoter sequence. A coding nucleic acid sequence is “operably linked” to a regulatory sequence (e.g., promoter) if the regulatory sequence is capable of exerting a regulatory effect on the coding sequence linked thereto. 20 As used herein, the term “promoter” refers to a region of DNA which lies upstream of the transcriptional initiation site of a gene to which RNA polymerase binds to initiate transcription of RNA. The promoter controls where (e.g., which portion of a plant) and/or when (e.g., at which stage or condition in the lifetime of an organism) the gene is expressed. 25 Any suitable promoter sequence can be used by the nucleic acid construct of the present invention. According to some embodiments of the invention, the promoter is a constitutive promoter, a tissue-specific, or an abiotic stress-inducible promoter.

Suitable constitutive promoters include, for example, CaMV 35S promoter (SEQ ID NO:4196; Odell et al., Nature 313:810-812, 1985); Arabidopsis At6669 promoter 30 (SEQ ID NO:4195; see PCT Publication No. W004081173A2); Arabidopsis new At6669 promoter (SEQ ID NO:4198); maize Ubi 1 (Christensen et ah, Plant Sol. Biol. 18:675-689, 1992); rice actin (McElroy et ah, Plant Cell 2:163-171, 1990); pEMU (Last 2016213786 11 Aug 2016 25 et al., Theor. Appl. Genet. 81:581-588, 1991); CaMV 19S (Nilsson et al., Physiol. Plant 100:456-462, 1997); GOS2 (de Pater et al, Plant J Nov;2(6):837-44, 1992); ubiquitin (Christensen et al, Plant Mol. Biol. 18: 675-689, 1992); Rice cyclophilin (Bucholz et al, Plant Mol Biol. 25(5):837-43, 1994); Maize H3 histone (Lepetit et al, Mol. Gen. Genet. 5 231: 276-285, 1992); Actin 2 (An et al, Plant J. 10(1); 107-121, 1996) and Synthetic

Super MAS (Ni et al., The Plant Journal 7: 661-76, 1995). Other constitutive promoters include those in U.S. Pat. Nos. 5,659,026, 5,608,149; 5.608,144; 5,604,121; 5.569,597: 5.466,785; 5,399,680; 5,268,463; and 5,608,142.

Suitable tissue-specific promoters include, but not limited to, leaf-specific 10 promoters [such as described, for example, by Yamamoto et al., Plant J. 12:255-265, 1997; Kwon et al., Plant Physiol. 105:357-67, 1994; Yamamoto et al., Plant Cell Physiol. 35:773-778, 1994; Gotor et al., Plant J. 3:509-18, 1993; Orozco et al., Plant Mol. Biol. 23:1129-1138, 1993; and Matsuoka et al., Proc. Natl. Acad. Sci. USA 90:9586-9590, 1993], seed-preferred promoters [e.g., from seed specific genes (Simon, 15 et al., Plant Mol. Biol. 5. 191, 1985; Scofield, et al., J. Biol. Chem. 262: 12202, 1987; Baszczynski, et al., Plant Mol. Biol. 14: 633, 1990), Brazil Nut albumin (Pearson' et al., Plant Mol. Biol. 18: 235- 245, 1992), legumin (Ellis, et al. Plant Mol. Biol. 10: 203-214, 1988), Glutelin (rice) (Takaiwa, et al., Mol. Gen. Genet. 208: 15-22, 1986; Takaiwa, et al., FEBS Letts. 221: 43-47, 1987), Zein (Matzke et al., Plant Mol Biol, 143).323-32 20 1990), napA (Stalberg, et al., Planta 199: 515-519, 1996), Wheat SPA (Albanietal, Plant

Cell, 9: 171- 184, 1997), sunflower oleosin (Cummins, etal., Plant Mol. Biol. 19: 873-876, 1992)], endosperm specific promoters [e.g., wheat LMW and HMW, glutenin-1 (Mol Gen Genet 216:81-90, 1989; NAR 17:461-2), wheat a, b and g gliadins (EMB03:1409-15, 1984), Barley ltrl promoter, barley Bl, C, D hordein (Theor Appl 25 Gen 98:1253-62, 1999; Plant J 4:343-55, 1993; Mol Gen Genet 250:750- 60, 1996), Barley DOF (Mena et al., The Plant Journal, 116(1): 53- 62, 1998), Biz2 (EP99106056.7), Synthetic promoter (Vicente-Carbajosa et al., Plant J. 13: 629-640, 1998), rice prolamin NRP33, rice -globulin Glb-1 (Wu et al., Plant Cell Physiology 39(8) 885- 889, 1998), rice alpha-globulin REB/OHP-1 (Nakase et al. Plant Mol. Biol. 30 33: 513-S22, 1997), rice ADP-glucose PP (Trans Res 6:157-68, 1997), maize ESR gene family (Plant J 12:235-46, 1997), sorghum gamma- kafirin (PMB 32:1029-35, 1996); e.g., the Napin promoter (SEQ ID NO:4197)], embryo specific promoters [e.g., rice 2016213786 11 Aug 2016 26 OSH1 (Sato et al., Proc. Natl. Acad. Sci. USA, 93: 8117-8122), KNOX (Postma-Haarsma et al, Plant Mol. Biol. 39:257-71, 1999), rice oleosin (Wu et at, J. Biochem., 123:386, 1998)], and flower-specific promoters [e.g., AtPRP4, chalene synthase (chsA) (Van der Meer, et al., Plant Mol. Biol. 15, 95-109, 1990), LAT52 (Twell et al., Mol. Gen 5 Genet. 217:240-245; 1989), apetala- 3],

Suitable abiotic stress-inducible promoters include, but not limited to, salt-inducible promoters such as RD29A (Yamaguchi-Shinozalei et al., Mol. Gen. Genet. 236:331-340, 1993); drought-inducible promoters such as maize rabl7 gene promoter (Pla et al., Plant Mol. Biol. 21:259-266, 1993), maize rab28 gene promoter (Busk et al., 10 Plant J. 11:1285-1295, 1997) and maize Ivr2 gene promoter (Pelleschi et al., Plant Mol. Biol. 39:373-380, 1999); heat-inducible promoters such as heat tomato hsp80-promoter from tomato (U.S. Pat. No. 5,187,267).

The nucleic acid construct of some embodiments of the invention can further include an appropriate selectable marker and/or an origin of replication. According to 15 some embodiments of the invention, the nucleic acid construct utilized is a shuttle vector, which can propagate both in E. coli (wherein the construct comprises an appropriate selectable marker and origin of replication) and be compatible with propagation in cells. The construct according to some embodiments of the invention can be, for example, a plasmid, a bacmid, a phagemid, a cosmid, a phage, a virus or an 20 artificial chromosome.

The nucleic acid construct of some embodiments of the invention can be utilized to stably or transiently transform plant cells. In stable transformation, the exogenous polynucleotide is integrated into the plant genome and as such it represents a stable and inherited trait. In transient transformation, the exogenous polynucleotide is expressed by 25 the cell transformed but it is not integrated into the genome and as such it represents a transient trait.

There are various methods of introducing foreign genes into both monocotyledonous and dicotyledonous plants (Potrykus, I., Annu. Rev. Plant. Physiol., Plant. Mol. Biol. (1991) 42:205-225; Shimamoto et al., Nature (1989) 30 338:274-276).

The principle methods of causing stable integration of exogenous DNA into plant genomic DNA include two main approaches: 2016213786 11 Aug 2016 27 (i) Agrobacterium-mediated gene transfer (e.g., T-DNA using Agrobacterium tumefaciens or Agrobacterium rhizogenes); see for example, Klee et al. (1987) Annu. Rev. Plant Physiol. 38:467-486; Klee and Rogers in Cell Culture and Somatic Cell Genetics of Plants, Vol. 6, Molecular Biology of Plant Nuclear Genes, 5 eds. Schell, J., and Vasil, L. K., Academic Publishers, San Diego, Calif. (1989) p. 2-25; Gatenby, in Plant Biotechnology, eds. Kung, S, and Amtzen, C. J., Butterworth Publishers, Boston, Mass. (1989) p. 93-112. (ii) Direct DNA uptake: Paszkowski et al., in Cell Culture and Somatic Cell Genetics of Plants, Vol. 6, Molecular Biology of Plant Nuclear Genes eds. Schell, J., 10 and Vasil, L. K., Academic Publishers, San Diego, Calif. (1989) p. 52-68; including methods for direct uptake of DNA into protoplasts, Toriyama, K. et al. (1988) Bio/Technology 6:1072-1074. DNA uptake induced by brief electric shock of plant cells: Zhang et al. Plant Cell Rep. (1988) 7:379-384. Fromm et al. Nature (1986) 319:791-793. DNA injection into plant cells or tissues by particle bombardment, Klein 15 et al. Bio/Technology (1988) 6:559-563; McCabe et al. Bio/Technology (1988) 6:923-926; Sanford, Physiol. Plant. (1990) 79:206-209; by the use of micropipette systems: Neuhaus et al., Theor. Appl. Genet. (1987) 75:30-36; Neuhaus and Spangenberg, Physiol. Plant. (1990) 79:213-217; glass fibers or silicon carbide whisker transformation of cell cultures, embryos or callus tissue, U.S. Pat. No. 5,464,765 or by 20 the direct incubation of DNA with germinating pollen, DeWet et al. in Experimental Manipulation of Ovule Tissue, eds. Chapman, G. P. and Mantell, S. H. and Daniels, W. Longman, London, (1985) p. 197-209; and Ohta, Proc. Natl. Acad. Sci. USA (1986) 83:715-719.

The Agrobacterium system includes the use of plasmid vectors that contain 25 defined DNA segments that integrate into the plant genomic DNA. Methods of inoculation of the plant tissue vary depending upon the plant species and the Agrobacterium delivery system. A widely used approach is the leaf disc procedure which can be performed with any tissue explant that provides a good source for initiation of whole plant differentiation. See, e.g., Horsch et al. in Plant Molecular Biology 30 Manual A5, Kluwer Academic Publishers, Dordrecht (1988) p. 1-9. A supplementary approach employs the Agrobacterium delivery system in combination with vacuum 28 infiltration. The Agrobacterium system is especially viable in the creation of transgenic dicotyledonous plants.

There are various methods of direct DNA transfer into plant cells. In electroporation, the protoplasts are briefly exposed to a strong electric field. In microinjection, the DNA is mechanically injected directly into the cells using very small micropipettes. In microparticle bombardment, the DNA is adsorbed on microprojectiles such as magnesium sulfate crystals or tungsten particles, and the microprojectiles are physically accelerated into cells or plant tissues.

Following stable transformation plant propagation is exercised. The most common method of plant propagation is by seed. Regeneration by seed propagation, however, has the deficiency that due to heterozygosity there is a lack of uniformity in the crop, since seeds are produced by plants according to the genetic variances governed by Mendelian rules. Basically, each seed is genetically different and each will grow with its own specific traits. Therefore, it is preferred that the transformed plant be produced such that the regenerated plant has the identical traits and characteristics of the parent transgenic plant. For this reason it is preferred that the transformed plant be regenerated by micropropagation which provides a rapid, consistent reproduction of the transformed plants.

Micropropagation is a process of growing new generation plants from a single piece of tissue that has been excised from a selected parent plant or cultivar. This process permits the mass reproduction of plants having the preferred tissue expressing the fusion protein. The new generation plants which are produced are genetically identical to, and have all of the characteristics of, the original plant. Micropropagation allows mass production of quality plant material in a short period of time and offers a rapid multiplication of selected cultivars in the preservation of the characteristics of the original transgenic or transformed plant. The advantages of cloning plants are the speed of plant multiplication and the quality and uniformity of plants produced.

Micropropagation is a multi-stage procedure that requires alteration of culture medium or growth conditions between stages. Thus, the micropropagation process involves four basic stages: Stage one, initial tissue culturing; stage two, tissue culture multiplication; stage three, differentiation and plant formation; and stage four, greenhouse culturing and hardening. During stage one, initial tissue culturing, the tissue 2016213786 11 Aug 2016 29 culture is established and certified contaminant-free. During stage two, the initial tissue culture is multiplied until a sufficient number of tissue samples are produced to meet production goals. During stage three, the tissue samples grown in stage two are divided and grown into individual plantlets. At stage four, the transformed plantlets are 5 transferred to a greenhouse for hardening where the plants' tolerance to light is gradually increased so that it can be grown in the natural environment.

According to some embodiments of the invention, the transgenic plants are generated by transient transformation of leaf cells, meristematic cells or the whole plant.

Transient transformation can be effected by any of the direct DNA transfer 10 methods described above or by viral infection using modified plant viruses.

Viruses that have been shown to be useful for the transformation of plant hosts include CaMV, Tobacco mosaic virus (TMV), brome mosaic virus (BMV) and Bean Common Mosaic Virus (BV or BCMV). Transformation of plants using plant viruses is described in U.S. Pat. No. 4,855,237 (bean golden mosaic virus; BGV), EP-A 67,553 15 (TMV), Japanese Published Application No. 63-14693 (TMV), EPA 194,809 (BV), EPA 278,667 (BV); and Gluzman, Y. et al., Communications in Molecular Biology: Viral Vectors, Cold Spring Harbor Laboratory, New York, pp. 172-189 (1988). Pseudovirus particles for use in expressing foreign DNA in many hosts, including plants are described in WO 87/06261. 20 According to some embodiments of the invention, the virus used for transient transformations is avirulent and thus is incapable of causing severe symptoms such as reduced growth rate, mosaic, ring spots, leaf roll, yellowing, streaking, pox formation, tumor formation and pitting. A suitable avirulent virus may be a naturally occurring avirulent virus or an artificially attenuated virus. Virus attenuation may be effected by 25 using methods well known in the art including, but not limited to, sub-lethal heating, chemical treatment or by directed mutagenesis techniques such as described, for example, by Kurihara and Watanabe (Molecular Plant Pathology 4:259-269, 2003), Galon et al. (1992), Atreya et al. (1992) and Huet et al. (1994).

Suitable virus strains can be obtained from available sources such as, for 30 example, the American Type culture Collection (ATCC) or by isolation from infected plants. Isolation of viruses from infected plant tissues can be effected by techniques well known in the art such as described, for example by Foster and Tatlor, Eds. “Plant 2016213786 11 Aug 2016 30

Virology Protocols: From Virus Isolation to Transgenic Resistance (Methods in Molecular Biology (Humana Pr), Vol 81)”, Humana Press, 1998. Briefly, tissues of an infected plant believed to contain a high concentration of a suitable virus, preferably young leaves and flower petals, are ground in a buffer solution (e.g., phosphate buffer 5 solution) to produce a virus infected sap which can be used in subsequent inoculations.

Construction of plant RNA viruses for the introduction and expression of non-viral exogenous polynucleotide sequences in plants is demonstrated by the above references as well as by Dawson, W. O. et al., Virology (1989) 172:285-292; Takamatsu et al. EMBO J. (1987) 6:307-311; French et al. Science (1986) 231:1294-1297; 10 Takamatsu et al. FEBS Fetters (1990) 269:73-76; and U.S. Pat. No. 5,316,931.

When the vims is a DNA vims, suitable modifications can be made to the vims itself. Alternatively, the vims can first be cloned into a bacterial plasmid for ease of constmcting the desired viral vector with the foreign DNA. The vims can then be excised from the plasmid. If the vims is a DNA vims, a bacterial origin of replication 15 can be attached to the viral DNA, which is then replicated by the bacteria. Transcription and translation of this DNA will produce the coat protein which will encapsidate the viral DNA. If the vims is an RNA vims, the vims is generally cloned as a cDNA and inserted into a plasmid. The plasmid is then used to make all of the constructions. The RNA vims is then produced by transcribing the viral sequence of the plasmid and 20 translation of the viral genes to produce the coat protein(s) which encapsidate the viral RNA.

In one embodiment, a plant viral polynucleotide is provided in which the native coat protein coding sequence has been deleted from a viral polynucleotide, a non-native plant viral coat protein coding sequence and a non-native promoter, preferably the 25 subgenomic promoter of the non-native coat protein coding sequence, capable of expression in the plant host, packaging of the recombinant plant viral polynucleotide, and ensuring a systemic infection of the host by the recombinant plant viral polynucleotide, has been inserted. Alternatively, the coat protein gene may be inactivated by insertion of the non-native polynucleotide sequence within it, such that a 30 protein is produced. The recombinant plant viral polynucleotide may contain one or more additional non-native subgenomic promoters. Each non-native subgenomic promoter is capable of transcribing or expressing adjacent genes or polynucleotide 31 sequences in the plant host and incapable of recombination with each other and with native subgenomic promoters. Non-native (foreign) polynucleotide sequences may be inserted adjacent the native plant viral subgenomic promoter or the native and a nonnative plant viral subgenomic promoters if more than one polynucleotide sequence is included. The non-native polynucleotide sequences are transcribed or expressed in the host plant under control of the subgenomic promoter to produce the desired products.

In a second embodiment, a recombinant plant viral polynucleotide is provided as in the first embodiment except that the native coat protein coding sequence is placed adjacent one of the non-native coat protein subgenomic promoters instead of a nonnative coat protein coding sequence.

In a third embodiment, a recombinant plant viral polynucleotide is provided in which the native coat protein gene is adjacent its subgenomic promoter and one or more non-native subgenomic promoters have been inserted into the viral polynucleotide. The inserted non-native subgenomic promoters are capable of transcribing or expressing adjacent genes in a plant host and are incapable of recombination with each other and with native subgenomic promoters. Non-native polynucleotide sequences may be inserted adjacent the non-native subgenomic plant viral promoters such that the sequences are transcribed or expressed in the host plant under control of the subgenomic promoters to produce the desired product.

In a fourth embodiment, a recombinant plant viral polynucleotide is provided as in the third embodiment except that the native coat protein coding sequence is replaced by a non-native coat protein coding sequence.

The viral vectors are encapsidated by the coat proteins encoded by the recombinant plant viral polynucleotide to produce a recombinant plant virus. The recombinant plant viral polynucleotide or recombinant plant virus is used to infect appropriate host plants. The recombinant plant viral polynucleotide is capable of replication in the host, systemic spread in the host, and transcription or expression of foreign gene(s) (exogenous polynucleotide) in the host to produce the desired protein.

Techniques for inoculation of viruses to plants may be found in Foster and Taylor, eds. “Plant Virology Protocols: From Virus Isolation to Transgenic Resistance (Methods in Molecular Biology (Humana Pr), Vol 81)”, Humana Press, 1998; Maramorosh and Koprowski, eds. “Methods in Virology” 7 vols, Academic Press, New 2016213786 11 Aug 2016 32

York 1967-1984; Hill, S.A. “Methods in Plant Virology”, Blackwell, Oxford, 1984; Walkey, D.G.A. “Applied Plant Virology”, Wiley, New York, 1985; and Kado and Agrawa, eds. “Principles and Techniques in Plant Virology”, Van Nostrand-Reinhold, New York. 5 In addition to the above, the polynucleotide of the present invention can also be introduced into a chloroplast genome thereby enabling chloroplast expression. A technique for introducing exogenous polynucleotide sequences to the genome of the chloroplasts is known. This technique involves the following procedures. First, plant cells are chemically treated so as to reduce the number of chloroplasts per cell to 10 about one. Then, the exogenous polynucleotide is introduced via particle bombardment into the cells with the aim of introducing at least one exogenous polynucleotide molecule into the chloroplasts. The exogenous polynucleotide is selected such that it is integratable into the chloroplast's genome via homologous recombination which is readily effected by enzymes inherent to the chloroplast. To this end, the exogenous 15 polynucleotide includes, in addition to a gene of interest, at least one polynucleotide stretch which is derived from the chloroplast's genome. In addition, the exogenous polynucleotide includes a selectable marker, which serves by sequential selection procedures to ascertain that all or substantially all of the copies of the chloroplast genomes following such selection will include the exogenous polynucleotide. Further 20 details relating to this technique are found in U.S. Pat. Nos. 4,945,050; and 5,693,507 which are incorporated herein by reference. A polypeptide can thus be produced by the protein expression system of the chloroplast and become integrated into the chloroplast's inner membrane.

Since yield (or other parameters affecting yield such as growth rate, biomass, 25 vigor, content of seeds, oil content and the like), fiber yield and/or quality, water use efficiency, fertilizer use efficiency, nitrogen use efficiency and/or abiotic stress tolerance in plants can involve multiple genes acting additively or in synergy (see, for example, in Quesda et al., Plant Physiol. 130:951-063, 2002), the invention also envisages expressing a plurality of exogenous polynucleotides in a single host plant to thereby 30 achieve superior effect on yield, fiber yield and/or quality, water use efficiency, fertilizer use efficiency, nitrogen use efficiency and/or abiotic stress tolerance. 2016213786 11 Aug 2016 33

Expressing a plurality of exogenous polynucleotides in a single host plant can be effected by co-introducing multiple nucleic acid constructs, each including a different exogenous polynucleotide, into a single plant cell. The transformed cell can then be regenerated into a mature plant using the methods described hereinabove. 5 Alternatively, expressing a plurality of exogenous polynucleotides in a single host plant can be effected by co-introducing into a single plant-cell a single nucleic-acid construct including a plurality of different exogenous polynucleotides. Such a construct can be designed with a single promoter sequence which can transcribe a polycistronic messenger RNA including all the different exogenous polynucleotide sequences. To 10 enable co-translation of the different polypeptides encoded by the polycistronic messenger RNA, the polynucleotide sequences can be inter-linked via an internal ribosome entry site (IRES) sequence which facilitates translation of polynucleotide sequences positioned downstream of the IRES sequence. In this case, a transcribed polycistronic RNA molecule encoding the different polypeptides described above will be 15 translated from both the capped 5' end and the two internal IRES sequences of the polycistronic RNA molecule to thereby produce in the cell all different polypeptides. Alternatively, the construct can include several promoter sequences each linked to a different exogenous polynucleotide sequence.

The plant cell transformed with the construct including a plurality of different 20 exogenous polynucleotides can be regenerated into a mature plant, using the methods described hereinabove.

Alternatively, expressing a plurality of exogenous polynucleotides can be effected by introducing different nucleic acid constructs, including different exogenous polynucleotides, into a plurality of plants. The regenerated transformed plants can then 25 be cross-bred and resultant progeny selected for superior yield (e.g., growth rate, biomass, vigor, oil content), fiber yield and/or quality, water use efficiency, fertilizer use efficiency, nitrogen use efficiency and/or abiotic stress tolerance traits, using conventional plant breeding techniques.

According to some embodiments of the invention, the plant expressing the 30 exogenous polynucleotide(s) is grown under non-stress or normal conditions (e.g., biotic conditions and/or conditions with sufficient water, nutrients such as nitrogen and 2016213786 11 Aug 2016 34 fertilizer). Such conditions, which depend on the plant being grown, are known to those skilled in the art of agriculture, and are further, described hereinbelow.

According to some embodiments of the invention, the method further comprising growing the plant expressing the exogenous polynucleotide under the abiotic stress. 5 Non-limiting examples of abiotic stress conditions include, salinity, drought, water deprivation, excess of water (e.g., flood, waterlogging), etiolation, low temperature, high temperature, heavy metal toxicity, anaerobiosis, nutrient deficiency, nutrient excess, atmospheric pollution and UV irradiation.

Thus, the invention encompasses plants exogenously expressing the 10 polynucleotide(s), the nucleic acid constructs and/or polypeptide(s) of the invention. Once expressed within the plant cell or the entire plant, the level of the polypeptide encoded by the exogenous polynucleotide can be determined by methods well known in the art such as, activity assays, Western blots using antibodies capable of specifically binding the polypeptide, Enzyme-Linked Immuno Sorbent Assay (ELISA), radio-15 immuno-assays (RIA), immunohistochemistry, immunocytochemistry, immunofluorescence and the like.

Methods of determining the level in the plant of the RNA transcribed from the exogenous polynucleotide are well known in the art and include, for example, Northern blot analysis, reverse transcription polymerase chain reaction (RT-PCR) analysis 20 (including quantitative, semi-quantitative or real-time RT-PCR) and RNA-//; situ hybridization.

The sequence information and annotations uncovered by the present teachings can be harnessed in favor of classical breeding. Thus, sub-sequence data of those polynucleotides described above, can be used as markers for marker assisted selection 25 (MAS), in which a marker is used for indirect selection of a genetic determinant or determinants of a trait of interest (e.g., biomass, growth rate, oil content, fiber yield and/or quality, yield, abiotic stress tolerance, water use efficiency, nitrogen use efficiency and/or fertilizer use efficiency). Nucleic acid data of the present teachings (DNA or RNA sequence) may contain or be linked to polymorphic sites or genetic 30 markers on the genome such as restriction fragment length polymorphism (RFLP), microsatellites and single nucleotide polymorphism (SNP), DNA fingerprinting (DFP), amplified fragment length polymorphism (AFLP), expression level polymorphism, 2016213786 11 Aug 2016 35 polymorphism of the encoded polypeptide and any other polymorphism at the DNA or RNA sequence.

Examples of marker assisted selections include, but are not limited to, selection for a morphological trait (e.g., a gene that affects form, coloration, male sterility or 5 resistance such as the presence or absence of awn, leaf sheath coloration, height, grain color, aroma of rice); selection for a biochemical trait (e.g., a gene that encodes a protein that can be extracted and observed; for example, isozymes and storage proteins); selection for a biological trait (e.g., pathogen races or insect biotypes based on host pathogen or host parasite interaction can be used as a marker since the genetic 10 constitution of an organism can affect its susceptibility to pathogens or parasites).

The polynucleotides and polypeptides described hereinabove can be used in a wide range of economical plants, in a safe and cost effective manner.

Plant lines exogenously expressing the polynucleotide or the polypeptide of the invention can be screened to identify those that show the greatest increase of the desired 15 plant trait.

The effect of the transgene (the exogenous polynucleotide encoding the polypeptide) on abiotic stress tolerance can be determined using known methods such as detailed below and in the Examples section which follows.

Plant’s growth rate, biomass, yield and/or vigor - Plant vigor can be calculated 20 by the increase in growth parameters such as leaf area, fiber length, rosette diameter, plant fresh weight and the like per time.

The growth rate can be measured using digital analysis of growing plants. For example, images of plants growing in greenhouse on plot basis can be captured every 3 days and the rosette area can be calculated by digital analysis. Rosette area growth is 25 calculated using the difference of rosette area between days of sampling divided by the difference in days between samples.

Evaluation of growth rate can be also done by measuring plant biomass produced, rosette area, leaf size or root length per time (can be measured in cm2 per day of leaf area). 30 Relative growth area can be calculated using Formula II.

Formula II:

Relative growth rate area = Regression coefficient of area along time course 2016213786 11 Aug 2016 36

Thus, the relative growth area rate is in units of 1/day and length growth rate is in units of 1/day.

Seed yield - Evaluation of the seed yield per plant can be done by measuring the amount (weight or size) or quantity (i. e., number) of dry seeds produced and harvested 5 from 8-16 plants and divided by the number of plants.

For example, the total seeds from 8-16 plants can be collected, weighted using e.g., an analytical balance and the total weight can be divided by the number of plants. Seed yield per growing area can be calculated in the same manner while taking into account the growing area given to a single plant. Increase seed yield per growing area 10 could be achieved by increasing seed yield per plant, and/or by increasing number of plants capable of growing in a given area.

Seed yield can be expressed as thousand kernel weight (1000-weight), which is extrapolated from the number of filled seeds counted and their total weight. Hence, an increased 1000-weight may result from an increased seed size and/or seed weight (e.g., 15 increase in embryo size and/or endosperm size). For example, the weight of 1000 seeds can be determined as follows: seeds are scattered on a glass tray and a picture is taken. Each sample is weighted and then using the digital analysis, the number of seeds in each sample is calculated.

The 1000 seeds weight can be calculated using formula III: 20 Formula III: 1000 Seed Weight = number of seed in sample/ sample weight X 1000

The Harvest Index can be calculated using Formula IV

Formula IV:

Harvest Index = Average seed yield per plant/ Average dry weight 25 Since the transgenic plants of the invention have increased yield, it is likely that these plants exhibit an increased growth rate (during at least part of their life cycle), relative to the growth rate of corresponding wild type plants at a corresponding stage in their life cycle. The increased growth rate may be specific to one or more parts of a plant (including seeds), or may be throughout substantially the whole plant. A plant 30 having an increased growth rate may also exhibit early flowering. Increased growth rate during the early stages in the life cycle of a plant may reflect enhanced vigor. The increase in growth rate may alter the harvest cycle (early maturing) of a plant allowing 37 plants to be sown later and/or harvested sooner than would otherwise be possible. If the growth rate is sufficiently increased, it may allow for the sowing of further seeds of the same plant species (for example sowing and harvesting of rice plants followed by sowing and harvesting of further rice plants all within one conventional growing period). Similarly, if the growth rate is sufficiently increased, it may allow for the sowing of further seeds of different plants species (for example the sowing and harvesting of rice plants followed by, for example, the sowing and optional harvesting of soybean, potato or any other suitable plant). Harvesting additional times from the same rootstock in the case of some plants may also be possible. Altering the harvest cycle of a plant may lead to an increase in annual biomass production per area (due to an increase in the number of times (say in a year) that any particular plant may be grown and harvested). An increase in growth rate may also allow for the cultivation of transgenic plants in a wider geographical area than their wild-type counterparts, since the territorial limitations for growing a crop are often determined by adverse environmental conditions either at the time of planting (early season) or at the time of harvesting (late season). Such adverse conditions may be avoided if the harvest cycle is shortened. The growth rate may be determined by deriving various parameters from growth curves, such parameters may be: T-Mid (the time taken for plants to reach 50% of their maximal size) and T-90 (time taken for plants to reach 90% of their maximal size).

According to some embodiments of the invention, increased yield of com may be manifested as one or more of the following: increase in the number of plants per growing area, increase in the number of ears per plant, increase in the number of rows per ear, number of kernels per ear row, kernel weight, thousand kernel weight (1000-weight), ear length/diameter, increase oil content per kernel and increase starch content per kernel.

As mentioned, the increase of plant yield can be determined by various parameters. For example, increased yield of rice may be manifested by an increase in one or more of the following: number of plants per growing area, number of panicles per plant, number of spikelets per panicle, number of flowers per panicle, increase in the seed filling rate, increase in thousand kernel weight (1000-weight), increase oil content 2016213786 11 Aug 2016 38 per seed, increase starch content per seed, among others. An increase in yield may also result in modified architecture, or may occur because of modified architecture.

Similarly, increased yield of soybean may be manifested by an increase in one or more of the following: number of plants per growing area, number of pods per plant, 5 number of seeds per pod, increase in the seed filling rate, increase in thousand seed weight (1000-weight), reduce pod shattering, increase oil content per seed, increase protein content per seed, among others. An increase in yield may also result in modified architecture, or may occur because of modified architecture.

Increased yield of canola may be manifested by an increase in one or more of 10 the following: number of plants per growing area, number of pods per plant, number of seeds per pod, increase in the seed filling rate, increase in thousand seed weight (1000-weight), reduce pod shattering, increase oil content per seed, among others. An increase in yield may also result in modified architecture, or may occur because of modified architecture. 15 Increased yield of cotton may be manifested by an increase in one or more of the following: number of plants per growing area, number of bolls per plant, number of seeds per boll, increase in the seed filling rate, increase in thousand seed weight (1000-weight), increase oil content per seed, improve fiber length, fiber strength, among others. An increase in yield may also result in modified architecture, or may occur 20 because of modified architecture.

Oil content - The oil content of a plant can be determined by extraction of the oil from the seed or the vegetative portion of the plant. Briefly, lipids (oil) can be removed from the plant (e.g., seed) by grinding the plant tissue in the presence of specific solvents (e.g., hexane or petroleum ether) and extracting the oil in a continuous extractor. 25 Indirect oil content analysis can be carried out using various known methods such as Nuclear Magnetic Resonance (NMR) Spectroscopy, which measures the resonance energy absorbed by hydrogen atoms in the liquid state of the sample [See for example, Conway TF. and Earle FR., 1963, Journal of the American Oil Chemists' Society; Springer Berlin / Heidelberg, ISSN: 0003-021X (Print) 1558-9331 (Online)]; the Near 30 Infrared (NI) Spectroscopy, which utilizes the absorption of near infrared energy (1100-2500 nm) by the sample; and a method described in WO/2001/023884, which is based on extracting oil a solvent, evaporating the solvent in a gas stream which forms oil 2016213786 11 Aug 2016 39 particles, and directing a light into the gas stream and oil particles which forms a detectable reflected light.

Fiber length can be measured using fibrograph. The fibrograph system was used to compute length in terms of "Upper Half Mean" length. The upper half mean (UHM) is 5 the average length of longer half of the fiber distribution. The fibrograph measures length in span lengths at a given percentage point (Hypertext Transfer Protocol ://World Wide Web (dot) cottoninc (dot) com/ClassificationofCotton/?Pg=4#Length).

Abiotic stress tolerance - Transformed (i.e., expressing the transgene) and non-transformed (wild type) plants are exposed to an abiotic stress condition, such as water 10 deprivation, suboptimal temperature (low temperature, high temperature), nutrient deficiency, nutrient excess, a salt stress condition, osmotic stress, high or low light conditions, heavy metal toxicity, anaerobiosis, atmospheric pollution and UV irradiation.

Salinity tolerance assay - Transgenic plants with tolerance to high salt concentrations are expected to exhibit better germination, seedling vigor or growth in 15 high salt. Salt stress can be effected in many ways such as, for example, by irrigating the plants with a hyperosmotic solution, by cultivating the plants hydroponically in a hyperosmotic growth solution (e.g., Hoagland solution with added salt), or by culturing the plants in a hyperosmotic growth medium [e.g., 50 % Murashige-Skoog medium (MS medium) with added salt]. Since different plants vary considerably in their tolerance to 20 salinity, the salt concentration in the irrigation water, growth solution, or growth medium can be adjusted according to the specific characteristics of the specific plant cultivar or variety, so as to inflict a mild or moderate effect on the physiology and/or morphology of the plants (for guidelines as to appropriate concentration see, Bernstein and Kafkafi, Root Growth Under Salinity Stress In: Plant Roots, The Hidden Half 3rd 25 ed. Waisel Y, Eshel A and Kafkafi U. (editors) Marcel Dekker Inc., New York, 2002, and reference therein).

For example, a salinity tolerance test can be performed by irrigating plants at different developmental stages with increasing concentrations of sodium chloride (for example 50 mM, 100 mM, 200 mM, 400 mM NaCl) applied from the bottom and from 30 above to ensure even dispersal of salt. Following exposure to the stress condition the plants are frequently monitored until substantial physiological and/or morphological effects appear in wild type plants. Thus, the external phenotypic appearance, degree of 2016213786 11 Aug 2016 40 chlorosis and overall success to reach maturity and yield progeny are compared between control and transgenic plants. Quantitative parameters of tolerance measured include, but are not limited to, the average wet and dry weight, growth rate, leaf size, leaf coverage (overall leaf area), the weight of the seeds yielded, the average seed size and 5 the number of seeds produced per plant. Transformed plants not exhibiting substantial physiological and/or morphological effects, or exhibiting higher biomass than wild-type plants, are identified as abiotic stress tolerant plants.

Osmotic tolerance test - Osmotic stress assays (including sodium chloride and PEG assays) are conducted to determine if an osmotic stress phenotype was sodium 10 chloride-specific or if it was a general osmotic stress related phenotype. Plants which are tolerant to osmotic stress may have more tolerance to drought and/or freezing. For salt and osmotic stress experiments, the medium is supplemented for example with 50 mM, 100 mM, 200 mM NaCl or 15 %, 20 % or 25 % PEG.

Drought tolerance assay - Soil-based drought screens are performed with plants 15 overexpressing the polynucleotides detailed above. Seeds from control Arabidopsis plants, or other transgenic plants overexpressing the polypeptide of the invention are germinated and transferred to pots. Drought stress is obtained after irrigation is ceased. Transgenic and control plants are compared to each other when the majority of the control plants develop severe wilting. Plants are re-watered after obtaining a significant 20 fraction of the control plants displaying a severe wilting. Plants are ranked comparing to controls for each of two criteria: tolerance to the drought conditions and recovery (survival) following re-watering.

Quantitative parameters of tolerance measured include, but are not limited to, the average wet and dry weight, growth rate, leaf size, leaf coverage (overall leaf area), the 25 weight of the seeds yielded, the average seed size and the number of seeds produced per plant. Transformed plants not exhibiting substantial physiological and/or morphological effects, or exhibiting higher biomass than wild-type plants, are identified as drought stress tolerant plants

Cold stress tolerance - One way to analyze cold stress is as follows. Mature (25 30 day old) plants are transferred to 4 °C chambers for 1 or 2 weeks, with constitutive light. Later on plants are moved back to greenhouse. Two weeks later damages from chilling period, resulting in growth retardation and other phenotypes, are compared between 41 control and transgenic plants, by measuring plant weight (wet and dry), and by comparing growth rates measured as time to flowering, plant size, yield, and the like.

Heat stress tolerance - One way to measure heat stress tolerance is by exposing the plants to temperatures above 34 °C for a certain period. Plant tolerance is examined after transferring the plants back to 22 °C for recovery and evaluation after 5 days relative to internal controls (non-transgenic plants) or plants not exposed to neither cold or heat stress.

Germination tests - Germination tests compare the percentage of seeds from transgenic plants that could complete the germination process to the percentage of seeds from control plants that are treated in the same manner. Normal conditions are considered for example, incubations at 22 °C under 22-hour light 2-hour dark daily cycles. Evaluation of germination and seedling vigor is conducted between 4 and 14 days after planting. The basal media is 50 % MS medium (Murashige and Skoog, 1962 Plant Physiology 15, 473-497).

Germination is checked also at unfavorable conditions such as cold (incubating at temperatures lower than 10 °C instead of 22 °C) or using seed inhibition solutions that contain high concentrations of an osmolyte such as sorbitol (at concentrations of 50 mM, 100 mM, 200 mM, 300 mM, 500 mM, and up to 1000 mM) or applying increasing concentrations of salt (of 50 mM, 100 mM, 200 mM, 300 mM, 500 mM NaCl).

Water use efficiency (WUE) - can be determined as the biomass produced per unit transpiration. To analyze WUE, leaf relative water content can be measured in control and transgenic plants. Fresh weight (FW) is immediately recorded; then leaves are soaked for 8 hours in distilled water at room temperature in the dark, and the turgid weight (TW) is recorded. Total dry weight (DW) is recorded after drying the leaves at 60 °C to a constant weight. Relative water content (RWC) is calculated according to the following Formula V:

Formula V RWC = (FW - DW/TW - DW) x 100

Plants that maintain high relative water content (RWC) compared to control lines are considered more tolerant to drought than those exhibiting reduced relative water content. A non limiting example in Arabidopsis is when water uptake by roots matches water loss by transpiration from leaves. Under these circumstances the plant is 2016213786 11 Aug 2016 42 determined to be under equilibrium and the RWC is about 0.9. When the RWC of transgenic plants decreases significantly less as compared to wild type plants, the transgenic plants are considered more tolerant to drought [Gaxiola et al. PNAS September 25, 2001 vol. 98 no. 20 11444-11449]. 5 Fertilizer use efficiency - To analyze whether the transgenic plants are more responsive to fertilizers, plants are grown in agar plates or pots containing growth media with a limited amount of fertilizer (e.g., nitrogen, phosphate, potassium), essentially as described in Yanagisawa et al (Proc Natl Acad Sci USA. 2004; 101:7833-8). The plants are analyzed for their overall size, time to flowering, yield, protein content of 10 shoot, grain and/or seed production. The parameters checked are the overall size of the mature plant, its wet and dry weight, the weight of the seeds yielded, the average seed size and the number of seeds produced per plant. Other parameters that may be tested are: the chlorophyll content of leaves (as nitrogen plant status and the degree of leaf greenness is highly correlated), amino acid and the total protein content of the seeds or 15 other plant parts such as leaves or shoots, oil content, etc. In this way, nitrogen use efficiency (NUE), phosphate use efficiency (PUE) and potassium use efficiency (KUE) are assessed, checking the ability of the transgenic plants which express the exogenous polynucleotide of the invention to thrive under nutrient restraining conditions. For example, to analyze whether the transgenic Arabidopsis plants are more responsive to 20 phosphate, plants are grown in 250 mM (phosphate deficient conditions) or 1 mM (optimal phosphate concentration). To test the potassium use efficiency, Arabidopsis plants which express the exogenous polynucleotide of the invention are grown in 0.03 mM potassium (potassium deficient conditions) or 3 mM potassium (optimal potassium concentration) essentially as described by Watson et al. Plant Physiol. (1996) 11 1 : 25 1077-1 083.

Nitrogen determination - The procedure for N (nitrogen) concentration determination in the structural parts of the plants involves the potassium persulfate digestion method to convert organic N to NO3' (Purcell and King 1996 Argon. J. 88:111-113, the modified Cd' mediated reduction of NO3" to NO2" (Vodovotz 1996 30 Biotechniques 20:390-394) and the measurement of nitrite by the Griess assay (Vodovotz 1996, supra). The absorbance values are measured at 550 nm against a 2016213786 11 Aug 2016 43 standard curve of NaNC>2. The procedure is described in details in Samonte et al. 2006 Agron. J. 98:168-176.

Nitrogen use efficiency - To analyze whether the transgenic Arabidopsis plants are more responsive to nitrogen plant are grown in 0.75- 1.5 mM (nitrogen deficient 5 conditions) or 6-10 mM (optimal nitrogen concentration). Plants are allowed to grow for additional 20 days or until seed production. The plants are then analyzed for their overall size, time to flowering, yield, protein content of shoot and/or grain/ seed production. The parameters checked can be the overall size of the plant, wet and dry weight, the weight of the seeds yielded, the average seed size and the number of seeds 10 produced per plant. Other parameters that may be tested are: the chlorophyll content of leaves (as nitrogen plant status and the degree of leaf greenness is highly correlated), amino acid and the total protein content of the seeds or other plant parts such as leaves or shoots and oil content. Transformed plants not exhibiting substantial physiological and/or morphological effects, or exhibiting higher measured parameters levels than wild-15 type plants, are identified as nitrogen use efficient plants.

Nitrogen use efficiency assay using plantlets - The assay is done according to Yanagisawa-S. et al. with minor modifications (“Metabolic engineering with Dofl transcription factor in plants: Improved nitrogen assimilation and growth under low-nitrogen conditions” Proc. Natl. Acad. Sci. USA 101, 7833-7838). Briefly, transgenic 20 plants which are grown for 7-10 days in 0.5 x MS [Murashige-Skoog] supplemented with a selection agent are transferred to two nitrogen-limiting conditions: MS media in which the combined nitrogen concentration (NH4NO3 and KNO3) was 0.2 mM or 0.05 mM. Plants are allowed to grow for additional 30-40 days and then photographed, individually removed from the Agar (the shoot without the roots) and immediately 25 weighed (fresh weight) for later statistical analysis. Constructs for which only T1 seeds are available are sown on selective media and at least 25 seedlings (each one representing an independent transformation event) are carefully transferred to the nitrogen-limiting media. For constructs for which T2 seeds are available, different transformation events are analyzed. Usually, 25 randomly selected plants from each 30 event are transferred to the nitrogen-limiting media allowed to grow for 3-4 additional weeks and individually weighed at the end of that period. Transgenic plants are compared to control plants grown in parallel under the same conditions. Mock- 2016213786 11 Aug 2016 44 transgenic plants expressing the uidA reporter gene (GUS) under the same promoter are used as control.

Grain protein concentration - Grain protein content (g grain protein m~2) is estimated as the product of the mass of grain N (g grain N m'2) multiplied by the 5 N/protein conversion ratio of k-5.13 (Mosse 1990, supra). The grain protein concentration is estimated as the ratio of grain protein content per unit mass of the grain (g grain protein kg'1 grain).

Thus, the present invention is of high agricultural value for promoting the yield, 10 biomass, growth rate, vigor, water use efficiency, fertilizer use efficiency, nitrogen use efficiency and abiotic stress tolerance of commercially desired crops (e.g., biomass of vegetative organ such as poplar wood, or reproductive organ such as number of seeds or seed biomass). 15 As used herein the term “about” refers to + 10 %.

The terms "comprises", "comprising", "includes", "including", “having” and their conjugates mean "including but not limited to".

The term “consisting of means “including and limited to”.

The term "consisting essentially of' means that the composition, method or 20 structure may include additional ingredients, steps and/or parts, but only if the additional ingredients, steps and/or parts do not materially alter the basic and novel characteristics of the claimed composition, method or structure.

As used herein, the singular form "a", "an" and "the" include plural references unless the context clearly dictates otherwise. For example, the term "a compound" or "at 25 least one compound" may include a plurality of compounds, including mixtures thereof.

Throughout this application, various embodiments of this invention may be presented in a range format. It should be understood that the description in range format is merely for convenience and brevity and should not be construed as an inflexible limitation on the scope of the invention. Accordingly, the description of a range should 30 be considered to have specifically disclosed all the possible subranges as well as individual numerical values within that range. For example, description of a range such as from 1 to 6 should be considered to have specifically disclosed subranges such as 45 from 1 to 3, from 1 to 4, from 1 to 5, from 2 to 4, from 2 to 6, from 3 to 6 etc., as well as individual numbers within that range, for example, 1, 2, 3, 4, 5, and 6. This applies regardless of the breadth of the range.

Whenever a numerical range is indicated herein, it is meant to include any cited numeral (fractional or integral) within the indicated range. The phrases “ranging/ranges between” a first indicate number and a second indicate number and “ranging/ranges from” a first indicate number “to” a second indicate number are used herein interchangeably and are meant to include the first and second indicated numbers and all the fractional and integral numerals therebetween.

As used herein the term "method" refers to manners, means, techniques and procedures for accomplishing a given task including, but not limited to, those manners, means, techniques and procedures either known to, or readily developed from known manners, means, techniques and procedures by practitioners of the chemical, pharmacological, biological, biochemical and medical arts.

It is appreciated that certain features of the invention, which are, for clarity, described in the context of separate embodiments, may also be provided in combination in a single embodiment. Conversely, various features of the invention, which are, for brevity, described in the context of a single embodiment, may also be provided separately or in any suitable subcombination or as suitable in any other described embodiment of the invention. Certain features described in the context of various embodiments are not to be considered essential features of those embodiments, unless the embodiment is inoperative without those elements.

Various embodiments and aspects of the present invention as delineated hereinabove and as claimed in the claims section below find experimental support in the following examples.

EXAMPLES

Reference is now made to the following examples, which together with the above descriptions illustrate some embodiments of the invention in a non limiting fashion. 2016213786 11 Aug 2016 46

Generally, the nomenclature used herein and the laboratory procedures utilized in the present invention include molecular, biochemical, microbiological and recombinant DNA techniques. Such techniques are thoroughly explained in the literature. See, for example, "Molecular Cloning: A laboratory Manual" Sambrook et 5 al., (1989); "Current Protocols in Molecular Biology" Volumes I-III Ausubel, R. M., ed. (1994); Ausubel et al., "Current Protocols in Molecular Biology", John Wiley and Sons, Baltimore, Maryland (1989); Perbal, "A Practical Guide to Molecular Cloning", John Wiley & Sons, New York (1988); Watson et al., "Recombinant DNA", Scientific American Books, New York; Birren et al. (eds) "Genome Analysis: A Laboratory 10 Manual Series", Vols. 1-4, Cold Spring Harbor Laboratory Press, New York (1998); methodologies as set forth in U.S. Pat. Nos. 4,666,828; 4,683,202; 4,801,531; 5,192,659 and 5,272,057; "Cell Biology: A Laboratory Handbook", Volumes I-III Cellis, J. E., ed. (1994); "Current Protocols in Immunology" Volumes I-III Coligan J. E., ed. (1994); Stites et al. (eds), "Basic and Clinical Immunology" (8th Edition), Appleton & Lange, 15 Norwalk, CT (1994); Mishell and Shiigi (eds), "Selected Methods in Cellular Immunology", W. H. Freeman and Co., New York (1980); available immunoassays are extensively described in the patent and scientific literature, see, for example, U.S. Pat. Nos. 3,791,932; 3,839,153; 3,850,752; 3,850,578; 3,853,987; 3,867,517; 3,879,262; 3,901,654; 3,935,074; 3,984,533; 3,996,345; 4,034,074; 4,098,876; 4,879,219; 20 5,011,771 and 5,281,521; "Oligonucleotide Synthesis" Gait, M. J., ed. (1984); “Nucleic

Acid Hybridization" Hames, B. D., and Higgins S. J., eds. (1985); "Transcription and Translation" Hames, B. D., and Higgins S. J., Eds. (1984); "Animal Cell Culture" Freshney, R. I., ed. (1986); "Immobilized Cells and Enzymes" IRL Press, (1986); "A Practical Guide to Molecular Cloning" Perbal, B., (1984) and "Methods in 25 Enzymology" Vol. 1-317, Academic Press; "PCR Protocols: A Guide To Methods And Applications", Academic Press, San Diego, CA (1990); Marshak et al., "Strategies for Protein Purification and Characterization - A Laboratory Course Manual" CSHL Press (1996); all of which are incorporated by reference as if fully set forth herein. Other general references are provided throughout this document. The procedures therein are 30 believed to be well known in the art and are provided for the convenience of the reader. All the information contained therein is incorporated herein by reference. 47 EXAMPLE 1

IDENTIFYING GENES WHICH IMPROVE YIELD AND AGRONOMICAL IMPORTANT TRAITS IN PLANTS

The present inventors have identified polynucleotides which expression thereof in plants can increase yield, fiber yield, fiber quality, growth rate, vigor, biomass, growth rate, oil content, abiotic stress tolerance (ABST), nitrogen use efficiency (NUE), water use efficiency (WUE) and fertilizer use efficiency (FUE) of a plant, as follows.

All nucleotide sequence datasets used here were originated from publicly available databases or from performing sequencing using the Solexa technology (e.g. Barley and Sorghum). Sequence data from 100 different plant species was introduced into a single, comprehensive database. Other information on gene expression, protein annotation, enzymes and pathways were also incorporated. Major databases used include: • Genomes o Arabidopsis genome [TAIR genome version 6 (Hypertext Transfer Protocol://World Wide Web (dot) arabidopsis (dot) org/)] o Rice genome [IRGSP build 4.0 (Hypertext Transfer Protocol://rgp (dot) dna (dot) affrc (dot) go (dot) jp/IRGSP/)]. o Poplar [Populus trichocarpa release 1.1 from JGI (assembly release vl.0) (Hypertext Transfer Protocol://World Wide Web (dot) genome (dot) jgi-psf (dot) org/)] o Brachypodium [JGI 4x assembly, Hypertext Transfer Protocol ://World Wide Web (dot) brachpodium (dot) org)] o Soybean [DOE-JGI SCP, version GlymaO (Hypertext Transfer Protocol://World Wide Web (dot) phytozome (dot) net/)] o Grape [French-Italian Public Consortium for Grapevine Genome Characterization grapevine genome (Hypertext Transfer Protocol:// World Wide Web (dot) genoscope (dot) cns (dot) fr /)] o Castobean [TIGR/J Craig Venter Institute 4x assembly [(Hypertext Transfer Protocol://msc (dot) jcvi (dot) org/r communis] o Sorghum [DOE-JGI SCP, version Sbil [Hypertext Transfer Protocol://World Wide Web (dot) phytozome (dot) net/)]. 48 o Partially assembled genome of Maize [Hypertext Transfer Protocol ://maizesequence (dot) org/] • Expressed EST and mRNA sequences were extracted from the following databases: o GeneBank versions 154, 157, 160, 161, 164, 165, 166 and 168 (Hypertext Transfer Protocol://World Wide Web (dot) ncbi (dot) nlm (dot) nih (dot) gov/dbEST/) o RefSeq (Hypertext Transfer Protocol ://World Wide Web (dot) ncbi (dot) nlm (dot) nih (dot) gov/RefSeq/). o TAIR (Hypertext Transfer Protocol://World Wide Web (dot) arabidopsis (dot) org/). • Protein and pathway databases o Uniprot [Hypertext Transfer Protocol://World Wide Web (dot) uniprot (dot) org/]. o AraCyc [Hypertext Transfer Protocol://World Wide Web (dot) arabidopsis (dot) org/biocyc/index (dot) jsp]. o ENZYME [Hypertext Transfer Protocol ://expasy (dot) org/enzyme/]. • Microarray datasets were downloaded from: o GEO (Hypertext Transfer Protocol://World Wide Web.ncbi.nlm.nih.gov/geo/) o TAIR (Hypertext Transfer Protocol://World Wide Web.arabidopsis.org/). o Proprietary microarray data (W02008/122980). • QTL and SNPs information o Gramene [Hypertext Transfer Protocol://World Wide Web (dot) gramene (dot) org/qtl/]. o Panzea [Hypertext Transfer Protocol://World Wide Web (dot) panzea (dot) org/index (dot) html].

Database Assembly - was performed to build a wide, rich, reliable annotated and easy to analyze database comprised of publicly available genomic mRNA, ESTs DNA sequences, data from various crops as well as gene expression, protein annotation and pathway data QTLs, and other relevant information.

Database assembly is comprised of a toolbox of gene refining, structuring, annotation and analysis tools enabling to construct a tailored database for each gene discovery project. Gene refining and structuring tools enable to reliably detect splice variants and antisense transcripts, generating understanding of various potential phenotypic outcomes of a single gene. The capabilities of the "LEADS" platform of 2016213786 11 Aug 2016 49

Compugen LTD for analyzing human genome have been confirmed and accepted by the scientific community [see e.g., "Widespread Antisense Transcription", Yelin, et al. (2003) Nature Biotechnology 21, 379-85; "Splicing of Alu Sequences", Lev-Maor, et al. (2003) Science 300 (5623), 1288-91; “Computational analysis of alternative splicing 5 using EST tissue information”, Xie H et al. Genomics 2002], and have been proven most efficient in plant genomics as well. EST clustering and gene assembly - For gene clustering and assembly of organisms with available genome sequence data (arabidopsis, rice, castorbean, grape, brachypodium, poplar, soybean, sorghum) the genomic LEADS version (GANG) was 10 employed. This tool allows most accurate clustering of ESTs and mRNA sequences on genome, and predicts gene structure as well as alternative splicing events and anti-sense transcription.

For organisms with no available full genome sequence data, "expressed LEADS" clustering software was applied. 15 Gene annotation - Predicted genes and proteins were annotated as follows:

Blast search [Hypertext Transfer Protocol://blast (dot) ncbi (dot) nlm (dot) nih (dot) gov /Blast (dot) cgi] against all plant UniProt [Hypertext Transfer Protocol ://World Wide Web (dot) uniprot (dot) org/] sequences was performed. Open reading frames of each putative transcript were analyzed and longest ORF with higher 20 number of homologues was selected as predicted protein of the transcript. The predicted proteins were analyzed by InterPro [Hypertext Transfer Protocol://World Wide Web (dot) ebi (dot) ac (dot) uk/interpro/].

Blast against proteins from AraCyc and ENZYME databases was used to map the predicted transcripts to AraCyc pathways. 25 Predicted proteins from different species were compared using blast algorithm [Hypertext Transfer Protocol ://World Wide Web (dot) ncbi (dot) nlm (dot) nih (dot) gov /Blast (dot) cgi] to validate the accuracy of the predicted protein sequence, and for efficient detection of ortho logs.

Gene expression profiling - Several data sources were exploited for gene 30 expression profiling, namely microarray data and digital expression profile (see below). According to gene expression profile, a correlation analysis was performed to identify 2016213786 11 Aug 2016 50 genes which are co-regulated under different development stages and environmental conditions and associated with different phenotypes.

Publicly available microarray datasets were downloaded from TAIR and NCBI GEO sites, renormalized, and integrated into the database. Expression profiling is one 5 of the most important resource data for identifying genes important for yield. A digital expression profile summary was compiled for each cluster according to all keywords included in the sequence records comprising the cluster. Digital expression, also known as electronic Northern Blot, is a tool that displays virtual expression profile based on the EST sequences forming the gene cluster. The tool 10 provides the expression profile of a cluster in terms of plant anatomy (e.g., the tissue/organ in which the gene is expressed), developmental stage (the developmental stages at which a gene can be found) and profile of treatment (provides the physiological conditions under which a gene is expressed such as drought, cold, pathogen infection, etc). Given a random distribution of ESTs in the different clusters, 15 the digital expression provides a probability value that describes the probability of a cluster having a total of N ESTs to contain X ESTs from a certain collection of libraries. For the probability calculations, the following is taken into consideration: a) the number of ESTs in the cluster, b) the number of ESTs of the implicated and related libraries, c) the overall number of ESTs available representing the species. Thereby clusters with 20 low probability values are highly enriched with ESTs from the group of libraries of interest indicating a specialized expression.

Recently, the accuracy of this system was demonstrated by Portnoy et al., 2009 (Analysis Of The Melon Fruit Transcriptome Based On 454 Pyrosequencing) in: Plant & Animal Genomes XVII Conference, San Diego, CA. Transcriptomic analysis, based 25 on relative EST abundance in data was performed by 454 pyrosequencing of cDNA representing mRNA of the melon fruit. Fourteen double strand cDNA samples obtained from two genotypes, two fruit tissues (flesh and rind) and four developmental stages were sequenced. GS FLX pyrosequencing (Roche/454 Life Sciences) of non-normalized and purified cDNA samples yielded 1,150,657 expressed sequence tags, that 30 assembled into 67,477 unigenes (32,357 singletons and 35,120 contigs). Analysis of the data obtained against the Cucurbit Genomics Database [Hypertext Transfer Protocol ://World Wide Web (dot) icugi (dot) org/] confirmed the accuracy of the 51 sequencing and assembly. Expression patterns of selected genes fitted well their qRT-PCR data.

To further investigate and identify putative ortho logs of the yield, growth rate, vigor, biomass, growth rate, abiotic stress tolerance (ABST), nitrogen use efficiency (NUE) and fertilizer use efficiency (FUE) genes from other plant species, expression data was analyzed and the EST libraries were classified using a fixed vocabulary of custom terms such as developmental stages (e.g., genes showing similar expression profile through development with up regulation at specific stage, such as at the seed filling stage) and/or plant organ (e.g., genes showing similar expression profile across their organs with up regulation at specific organs such as seed). The annotations from all the ESTs clustered to a gene were analyzed statistically by comparing their frequency in the cluster versus their abundance in the database, allowing to construct a numeric and graphic expression profile of that gene, which is termed “digital expression”. The rationale of using these two complementary methods with methods of phenotypic association studies of QTLs, SNPs and phenotype expression correlation is based on the assumption that true orthologs are likely to retain identical function over evolutionary time. These methods provide different sets of indications on function similarities between two homologous genes, similarities in the sequence level - identical amino acids in the protein domains and similarity in expression profiles.

Overall, 239 genes were identified to have a major impact on plant yield, growth rate, vigor, biomass, growth rate, oil content, abiotic stress tolerance, nitrogen use efficiency, water use efficiency and fertilizer use efficiency when expression thereof is increased in plants. The identified genes, their curated polynucleotide and polypeptide sequences, as well as their updated sequences according to Genbank database are summarized in Table 1, hereinbelow.

Table 1

Identified genes for increasing yield, growth rate, vigor, biomass, growth rate, oil content, abiotic stress tolerance, nitrogen use efficiency, water use efficiency and fertilizer use efficiency of a plant

Gene Name Cluster Name Organism Polynucleotide SEQ ID NO: Polypeptide SEQ ID NO: LYM1 rice gbl57.2 AU058137 rice 1 240 LYM2 rice gb!57.2AA750140 rice 2 241 2016213786 11 Aug 2016 LYM62 LYM61 LYM59 LYM57 LYM56 LYM53 LYM52 LYM51 LYM49 LYM44 LYM43 LYM42 LYM41 LYM40 LYM38 LYM37 LYM36 LYM35 LYM34 LYM32 LYM31 LYM30 LYM26 LYM24 LYM23 LYM22 LYM21 LYM20 LYM19 LYM17 LYM16 LYM15 LYM14 LYM13 LYM12 LYM10 LYM9 LYM8 LYM7 LYM6 LYM5 LYM4 LYM3 Gene Name maize | gb 1641BM348041 maize|gbl64|BM079029 barley|gbl57.3|BI952737 rice|gbl57.2|BI809626 barley|gbl57.3|BF625411 maize|gbl64|BE511332 barleylgbl 57.3 |BE422132 barleylgbl 57.3 |BE412472 maize|gbl64|AW331061 rice|gbl57.2|AU172519 rice|gbl57.2|AU101198 rice gbl57.2 AU097348 rice|gbl57.2|AU096202 rice|gbl57.2|AU082329 barley|gbl57.3|AL508889 rice gbl57.2 AK111353 rice|gbl 57.2|AK108674 rice|gbl 57.2|AK107934 rice gbl57.2 AK107902 rice|gbl57.2|AKl 06380 rice|gbl57.2|AK101734 rice|gbl 57.2|AK100743 barley|gbl57.3|AJ431915 rice|gbl57.2|AF050674 rice gbl57.2 AA749984 rice|gbl57.2|BI808357 rice|gbl57.2|BI805660 rice|gbl57.2|BF430570 rice|gbl57.2|BE040457 rice|gbl57.2|AU033038 rice|gbl57.2|U38074 rice|gbl57.2|CA761603 rice|gbl57.2|BM038118 rice|gbl57.2|BM037844 rice|gbl57.2|BI807331 rice|gbl57.2|BE230434 rice|gbl57.2|BE040806 rice|gbl57.2|BE040233 rice|gbl57.2|BE039635 rice|gbl57.2|AW155114 rice|gbl57.2|AW155107 rice gbl57.2 AU082697 rice|gbl57.2|AU032158 Cluster Name maize maize barley rice barley maize barley barley maize rice rice rice rice rice barley rice rice rice rice rice rice rice barley rice rice rice rice rice rice rice rice rice rice rice rice rice rice rice rice rice rice rice rice Organism 45 44 43 42 4^ 40 39 00 37 36 35 34 33 32 30 29 28 27 26 25 24 23 22 K> oz so 00 •o σ\ LAl bo - o 00 •o σ\ LAI 4^ LJ Polynucleotide SEQ ID NO: 282 281 280 279 278 LLZ 9 LZ 275 274 273 ZLZ 271 270 69Z 268 L9Z 99Z 265 P9Z 263 Z9Z 261 09Z 259 258 257 256 255 254 253 252 251 250 6PZ 248 247 9PZ 245 244 243 ZPZ Polypeptide SEQ ID NO: 2016213786 11 Aug 2016 LYM142 LYM141 LYM140 LYM137 LYM136 LYM134 LYM132 LYM131 LYM130 LYM129 LYM128 LYM127 LYM126 LYM125 LYM122 LYM120 LYM119 LYM111 LYM110 LYM106 LYM105 LYM103 LYM102 LYM100 LYM95 LYM99 LYM93 LYM91 LYM90 LYM89 LYM88 LYM86 LYM84 LYM83 LYM82 LYM79 LYM74 LYM73 LYM69 LYM68 LYM67 LYM66 Gene Name barley|gbl57.3|CB866504 rice gbl57.2 CA761074 barley|gbl57.3|BF623993 barley|gbl57.3|AL501911 rice|gbl57.2|AU093861 rice|gbl57.2|BI809462 rice|gbl57.3|BE229876 rice|gbl57.3|CF309827 rice|gbl57.3|BF430580 rice|gbl57.3|BE230206 rice gbl57.2AUl 72667 rice gbl57.2AUl 72589 rice|gbl57.2|AKl 08969 rice|gbl57.2|AKl 08452 rice|gbl 57.3 |BI118816 rice gbl57.3 BI795677 maize|gbl64|AW498426 maize|gbl64|AW053159 3 P N a 05 4^ w tn LAI LAi K> 05 00 barley|gbl57.3|BI954225 barley gbl57.3 AL507901 maize|gbl64|CD963970 rice|gbl57.2|CA760613 barley gbl57.3AV912944 barley gbl57.3 BI959932 barley gbl57.3 BI947870 barley gbl57.3 BI955752 barley|gbl57.3|BE060518 barley gbl57.3AV927104 arabidopsis gbl65 AT5G6749 0 arabidopsis gbl65 AT2G3775 0 rice|gbl57.2|AU031857 barley|gbl57.3|BF622069 barley|gbl57.3|BI952401 barley gbl57.3 AL507706 maize|gbl64|AW191191 maize|gbl64|CF075309 rice|gbl57.2|CB683204 rice|gbl57.2|CA997856 rice gbl57.2 CA767240 rice|gbl57.2|CA763759 barley gbl57.3 BU974981 Cluster Name barley rice barley barley rice rice rice rice rice rice rice rice rice rice rice rice maize maize maize barley barley maize rice barley barley barley barley barley barley arabidopsis arabidopsis rice barley barley barley maize maize rice rice rice rice barley Organism 87 98 85 84 00 82 00 08 79 78 77 76 75 74 73 72 •o 70 69 89 67 99 65 64 63 62 05 09 59 58 57 56 55 54 53 52 LAi 50 49 48 47 46 Polynucleotide SEQ ID NO: 324 323 322 321 320 319 00 317 316 U) LAi U) 4^ U) U) K) 310 309 U) o 00 307 306 305 304 303 302 301 U) o o 66Z 298 297 96Z 295 P6Z 293 Z6Z 291 290 289 288 287 286 285 284 283 Polypeptide SEQ ID NO: 2016213786 11 Aug 2016 LYM181 LYM180 LYM155 LYM154 LYM147 LYM146 LYM138 LYM135 LYM123 LYM121 LYM118 LYM117 LYM116 LYM115 LYM113 LYM112 LYM109 LYM107 LYM179 LYM178 LYM176 LYM175 LYM174 LYM173 LYM172 LYM170 LYM166 LYM165 LYM164 LYM162 LYM161 LYM160 LYM159 LYM157 LYM156 LYM153 LYM152 LYM149 LYM148 LYM145 LYM144 LYM143 Gene Name barleylgbl 57.3|AL450622 barley|gbl57.3|AJ476822 barleylgbl 57.3 |BE412535 barley|gbl57.3|AV836282 maize|gbl64|AI901828 maize|gbl64|AI770878 rice|gbl57.2|BI805497 rice|gbl57.2|AUl 01278 rice|gbl57.2|AI978352 rice|gbl57.2|AK103124 3 N* a σ' σ\ 4^ η ο LAi 00 00 4^ LJ maize|gbl64|AI739834 maize|gbl64|AI964572 maize|gbl64|CF646135 maize|gbl64|AW257902 maize|gbl64|CF038223 maize|gbl69.2|CD984002 maize|gbl64|AW497895 maize|gbl64|BE051631 barleylgbl 57.3 |BE421520 rice|gbl57.2|BI305434 rice|gbl57.2|AK060073 sorghum|gbl 61 ,crp|AW28430 3 rice|gbl57.3|AA751564 rice|gbl57.2|BE229411 rice|gbl57.2|AU057403 3 σ' a 5o“ σ' σ\ 4^ η <—1 LAi 4^ •ο LAi so maize|gbl64|CD439546 rice|gbl57.3|BI805693 maize|gbl64|BG462213 barleylgbl 57.3|BG344928 barley gbl57.3 BG300909 barleylgbl 57.3 |BF2593 87 barleylgbl 57.3 |BE454937 barleylgbl 57.3 |BE421631 rice|gbl57.3|AU066244 arabidopsis gbl65 AT5G5729 0 barley gbl57.3 AL509762 barleylgbl 57.3|AL500574 rice gbl57.2 AK073109 rice|gbl57.2|BM420331 rice|gbl57.3|BI306405 Cluster Name barley barley barley barley maize maize rice rice rice rice maize maize maize maize maize maize maize maize maize barley rice rice sorghum rice rice rice wheat maize rice maize barley barley barley barley barley rice arabidopsis barley barley rice rice rice Organism 129 128 127 126 125 124 123 122 120 so 00 •o σ\ LAI 4^ LJ K> - O 109 108 107 106 105 104 103 102 o 100 99 98 97 96 95 94 93 92 90 89 00 00 Polynucleotide SEQ ID NO: 366 365 364 363 362 361 360 359 358 357 356 355 354 353 352 351 350 349 348 347 346 345 344 343 342 341 340 339 338 337 336 335 334 333 332 331 330 329 328 327 326 325 Polypeptide SEQ ID NO: 2016213786 11 Aug 2016 LYM250 LYM249 LYM248 LYM245 LYM243 LYM242 LYM241 LYM240 LYM239 LYM238 LYM236 LYM234 LYM233 LYM232 LYM228 LYM227 LYM224 LYM223 LYM221 LYM220 LYM219 LYM217 LYM215 LYM213 LYM212 LYM208 LYM207 LYM206 LYM204 LYM203 LYM201 LYM198 LYM197 LYM196 LYM194 LYM193 LYM192 LYM189 LYM188 LYM186 LYM185 LYM184 LYM182 Gene Name ricelgbl 57.3 ICA759158 rice gbl57.3 C25903 rice gbl57.3 BQ906571 ricelgbl 57.3 |BF430828 ricelgbl 57.3 |BE228686 rice|gbl57.3|BE039711 rice gbl57.3AUl 62998 rice|gbl57.3|AU069131 rice|gbl57.3|AU068651 rice|gbl57.3|AK066551 rice|gbl57.3|AF 155334 rice|gbl57.3|AA752388 rice|gbl57.3|AA750182 rice|gbl57.3|AA750121 maize|gbl64|EC892599 maize|gbl64|EC877515 maize|gbl64|CA401086 maize|gbl64|BM338985 maize|gbl64|BI502603 maize|gbl64|BG842756 maize|gbl64|BE238495 maize|gbl64|BE129928 maize|gbl64|AW498464 maize|gbl64|AW000438 maize|gbl64|AW000408 maize |gb 1641AI941717 maize|gbl64|AI920398 maize |gb 1641AI691210 maize|gbl64|AI649791 maize|gbl64|AI629486 maize|gbl64|AI600670 maize|gbl64|AI491323 maize|gbl64|AI444704 maize|gbl64|AI372352 barley gbl57.3 CB860975 barley|gbl57.3|CB858276 barley|gbl57.3|BF627356 barleylgbl 57.3 |BF256192 barleylgbl 57.3 |BE43 8660 barley gbl57.3AV834971 barley gbl57.3AV833969 barley|gbl57.3|AV833284 barleylgbl 57.3|AL507048 Cluster Name rice rice rice rice rice rice rice rice rice rice rice rice rice rice maize maize maize maize maize maize maize maize maize maize maize maize maize maize maize maize maize maize maize maize barley barley barley barley barley barley barley barley barley Organism 172 •o 170 169 168 167 166 165 164 163 162 os 160 159 158 157 156 155 154 153 152 LAl 150 149 148 147 146 145 144 143 142 140 139 138 137 136 135 134 133 132 U) 130 Polynucleotide SEQ ID NO: 60b 408 407 406 405 404 403 402 401 400 399 so 00 397 396 395 394 393 392 391 390 U) 00 SO u> 00 00 387 00 Os 385 384 00 U) 382 00 U) 00 o 379 378 377 376 375 374 373 372 371 370 369 U) Os 00 367 Polypeptide SEQ ID NO: 2016213786 11 Aug 2016 LYM161 LYM159 LYM148 LYM95 LYM99 LYM90 LYM83 LYM79 LYM66 LYM59 LYM56 LYM52 LYM51 LYM42 LYM38 LYM293 LYM291 LYM290 LYM289 LYM288 LYM287 LYM285 LYM284 LYM283 LYM278 LYM277 LYM274 LYM273 LYM272 LYM271 LYM270 LYM268 LYM267 LYM200 LYM256 LYM183 LYM263 LYM261 LYM260 LYM255 LYM254 LYM252 LYM251 Gene Name barley gbl57.3 BG344928 barleylgbl 57.3 |BF2593 87 barleylgbl 57.3|AL500574 barley gbl57.3 BI959932 barley gbl57.3 BI947870 barley gbl57.3AV927104 barleylgbl 57.3|BI952401 maize|gbl64|AW191191 barley gbl57.3 BU974981 barleylgbl 57.3|BI952737 barley|gbl57.3|BF625411 barleylgbl 57.3 |BE422132 barleylgbl 57.3 |BE412472 rice gbl57.2 AU097348 barleylgbl 57.3|AL508889 rice|gbl57.2|AK059161 rice gbl57.2 BM037976 maize|gbl64|AA979729 barley gbl57.3AV925962 rice|gbl57.2|BE040927 rice|gbl57.2|AKl 02063 rice|gbl57.2|CB631346 rice|gbl57.2|BI306331 rice|gbl57.2|D23167 barleylgbl 57.3|BLYTRAA rice|gbl57.2|BM038097 rice|gbl57.2|AK073201 rice|gbl57.2|BM418692 rice|gbl57.2|CA761620 maize|gbl64|CF637107 maize|gbl64|AI670268 rice|gbl57.2|BI800054 maize|gbl64|AW231521 maize|gbl64|AI5 86731 rice gbl57.3 CI004090 barley gbl57.3 AL509795 sorghum|gb 161 ,crp| AI622410 rice|gbl 57.3 |D41406 rice|gbl 57.3 |CI581223 rice|gbl57.3|CF330913 rice|gbl57.3|CB657978 rice|gbl57.3|CA759659 rice|gbl57.3|CA759241 Cluster Name barley barley barley barley barley barley barley maize barley barley barley barley barley rice barley rice rice maize barley rice rice rice rice rice barley rice rice rice rice maize maize rice maize maize rice barley sorghum rice rice rice rice rice rice Organism 215 214 213 212 211 210 209 208 207 206 205 204 203 202 201 200 199 198 197 196 195 194 193 192 so 190 189 00 00 187 186 185 184 183 182 00 180 179 178 111 176 175 174 173 Polynucleotide SEQ ID NO: PPP 334 328 443 66Z 96Z 442 IPP OPP 279 LLZ 9 LZ 439 438 437 436 435 434 433 432 431 430 6ZP 428 427 9ZP 425 424 423 ZZP IZP 420 419 4^ 00 417 4^ σ\ 415 PIP 413 ZIP 4^ 4^ O Polypeptide SEQ ID NO: 57

Gene Name Cluster Name Organism Polynucleotide SEQ ID NO: Polypeptide SEQ ID NO: LYM166 wheat|gbl64|CJ547519 wheat 216 445 LYM175 rice gbl57.2|AK060073 rice 217 446 LYM109 maize|gbl64|CD984002 maize 218 447 LYM112 maize gbl64ICF038223 maize 219 448 LYM116 maize|gbl64|AI964572 maize 220 354 LYM117 maize|gbl64|AI739834 maize 221 449 LYM154 barley|gbl57.3 AV836282 barley 222 450 LYM155 barley|gbl57.3|BE412535 barley 223 451 LYM180 barley|gbl57.3|AJ476822 barley 224 452 LYM181 barley|gbl57.3|AL450622 barley 225 453 LYM184 barleylgb 157.31 AV833284 barley 226 454 LYM185 barleylgb 157.31 A V833969 barley 227 455 LYM186 barley|gbl57.3|AV834971 barley 228 370 LYM188 barley|gbl57.3|BE438660 barley 229 456 LYM189 barleylgbl 57.3 |BF256192 barley 230 457 LYM192 barley|gbl57.3|BF627356 barley 231 458 LYM193 barley|gbl57.3|CB858276 barley 232 459 LYM194 barley|gbl57.3|CB860975 barley 233 460 LYM219 maize|gbl 64|BE23 8495 maize 234 389 LYM221 maize|gbl64|BI502603 maize 235 461 LYM228 maize gbl64 EC892599 maize 236 462 LYM250 rice gbl57.3 CA759158 rice 237 463 LYM183 barley gbl57.3 AL509795 barley 238 464 LYM272 rice gbl57.2 CA761620 rice 239 465

Table 1: Provided are the identified genes, their annotation, organism and polynucleotide and polypeptide sequence identifiers. 2016213786 11 Aug 2016 EXAMPLE 2

5 IDENTIFICATION OF HOMOLOGOUS SEQUENCES THAT INCREASE YIELD, FIBER YIELD, FIBER QUALITY, GROWTH RATE, BIOMASS, OIL CONTENT, VIGOR, ABST, AND/OR NUE OF A PLANT The concepts of orthology and paralogy have recently been applied to functional characterizations and classifications on the scale of whole-genome comparisons. 10 Orthologs and paralogs constitute two major types of homologs: The first evolved from a common ancestor by specialization, and the latter are related by duplication events. It is assumed that paralogs arising from ancient duplication events are likely to have diverged in function while true orthologs are more likely to retain identical function over evolutionary time. 2016213786 11 Aug 2016 58

To identify putative ortho logs of the genes affecting plant yield, oil yield, oil content, seed yield, growth rate, vigor, biomass, abiotic stress tolerance and/or nitrogen use efficiency, all sequences were aligned using the BLAST (Basic Local Alignment Search Tool). Sequences sufficiently similar were tentatively grouped. These putative 5 orthologs were further organized under a Phylogram - a branching diagram (tree) assumed to be a representation of the evolutionary relationships among the biological taxa. Putative ortholog groups were analyzed as to their agreement with the phylogram and in cases of disagreements these ortholog groups were broken accordingly.

Expression data was analyzed and the EST libraries were classified using a fixed 10 vocabulary of custom terms such as developmental stages (e.g., genes showing similar expression profile through development with up regulation at specific stage, such as at the seed filling stage) and/or plant organ (e.g., genes showing similar expression profile across their organs with up regulation at specific organs such as seed). The annotations from all the ESTs clustered to a gene were analyzed statistically by comparing their 15 frequency in the cluster versus their abundance in the database, allowing the construction of a numeric and graphic expression profile of that gene, which is termed “digital expression”. The rationale of using these two complementary methods with methods of phenotypic association studies of QTLs, SNPs and phenotype expression correlation is based on the assumption that true orthologs are likely to retain identical 20 function over evolutionary time. These methods provide different sets of indications on function similarities between two homologous genes, similarities in the sequence level -identical amino acids in the protein domains and similarity in expression profiles.

The search and identification of homologous genes involves the screening of sequence information available, for example, in public databases such as the DNA 25 Database of Japan (DDBJ), Genbank, and the European Molecular Biology Laboratory Nucleic Acid Sequence Database (EMBL) or versions thereof or the MIPS database. A number of different search algorithms have been developed, including but not limited to the suite of programs referred to as BLAST programs. There are five implementations of BLAST, three designed for nucleotide sequence queries (BLASTN, BLASTX, and 30 TBLASTX) and two designed for protein sequence queries (BLASTP and TBLASTN) (Coulson, Trends in Biotechnology: 76-80, 1994; Birren et al., Genome Analysis, I: 543, 1997). Such methods involve alignment and comparison of sequences. The 2016213786 11 Aug 2016 59 BLAST algorithm calculates percent sequence identity and performs a statistical analysis of the similarity between the two sequences. The software for performing BLAST analysis is publicly available through the National Centre for Biotechnology Information. Other such software or algorithms are GAP, BESTFIT, FASTA and 5 TFASTA. GAP uses the algorithm of Needleman and Wunsch (J. Mol. Biol. 48: 443-453, 1970) to find the alignment of two complete sequences that maximizes the number of matches and minimizes the number of gaps.

The homologous genes may belong to the same gene family. The analysis of a gene family may be carried out using sequence similarity analysis. To perform this 10 analysis one may use standard programs for multiple alignments e.g. Clustal W. A neighbour-joining tree of the proteins homologous to the genes in this invention may be used to provide an overview of structural and ancestral relationships. Sequence identity may be calculated using an alignment program as described above. It is expected that other plants will carry a similar functional gene (ortholog) or a family of similar genes 15 and those genes will provide the same preferred phenotype as the genes presented here. Advantageously, these family members may be useful in the methods of the invention. Example of other plants are included here but not limited to, barley (Hordeum vulgare), Arabidopsis (Arabidopsis thaliana), maize (Zea mays), cotton (Gossypium), Oilseed rape (Brassica napus), Rice (Oryza sativa), Sugar cane (Saccharum officinarum), 20 Sorghum (Sorghum bicolor), Soybean (Glycine max), Sunflower (Helianthus annuus), Tomato (Lycopersicon esculentum), Wheat (Triticum aestivum).

The above-mentioned analyses for sequence homology can be carried out on a full-length sequence, but may also be based on a comparison of certain regions such as conserved domains. The identification of such domains, would also be well within the 25 realm of the person skilled in the art and would involve, for example, a computer readable format of the nucleic acids of the present invention, the use of alignment software programs and the use of publicly available information on protein domains, conserved motifs and boxes. This information is available in the PRODOM (Hypertext Transfer Protocol://World Wide Web (dot) biochem (dot) ucl (dot) ac (dot) 30 uk/bsm/dbbrowscr/protocol/prodomqry (dot) html), PIR (Hypertext Transfer Protocol ://pir (dot) Georgetown (dot) edu/) or Pfam (Hypertext Transfer Protocol://World Wide Web (dot) sanger (dot) ac (dot) uk/Software/Pfam/) database. 2016213786 11 Aug 2016 60

Sequence analysis programs designed for motif searching may be used for identification of fragments, regions and conserved domains as mentioned above. Preferred computer programs include, but are not limited to, MEME, SIGNALSCAN, and GENESCAN. A person skilled in the art may use the homologous sequences provided herein 5 to find similar sequences in other species and other organisms. Homologues of a protein encompass, peptides, oligopeptides, polypeptides, proteins and enzymes having amino acid substitutions, deletions and/or insertions relative to the unmodified protein in question and having similar biological and functional activity as the unmodified protein from which they are derived. To produce such homologues, amino acids of the protein 10 may be replaced by other amino acids having similar properties (conservative changes, such as similar hydrophobicity, hydrophilicity, antigenicity, propensity to form or break a-helical structures or 3-sheet structures). Conservative substitution tables are well known in the art (see for example Creighton (1984) Proteins. W.H. Freeman and Company). Homologues of a nucleic acid encompass nucleic acids having nucleotide 15 substitutions, deletions and/or insertions relative to the unmodified nucleic acid in question and having similar biological and functional activity as the unmodified nucleic acid from which they are derived.

Table 2, hereinbelow, lists a summary of orthologous and homologous sequences of the polynucleotide sequences (SEQ ID NOs: 1-239) and polypeptide 20 sequences (SEQ ID NOs:240-465) presented in Table 1 above, which were identified from the databases using the NCBI BLAST software (e.g., using the Blastp and tBlastn algorithms) and needle (EMBOSS package) as being at least 80% homologous to the selected polynucleotides and polypeptides, and which are expected to increase plant yield, seed yield, oil yield, oil content, growth rate, fiber yield, fiber quality, biomass, 25 vigor, ABST and/or NUE of a plant.

Table 2

Homologues of the identified genes/polypeptides for increasing yield, fiber yield, fiber quality, growth rate, vigor, biomass, growth rate, abiotic stress tolerance, nitrogen use 30 efficiency, water use efficiency and fertilizer use efficiency of a plant

Nucl. SEQ ID NO: Gene Name cluster name Polyp. SEQ ID NO: Homolog. to SEQ ID NO: % global identity Algor. 467 LYM2H5 brachypodium|09v 1 |D V480246 1974 241 89.1 blastp 2016213786 11 Aug 2016 4^ 4^ 4^ 4^ 4^ 4^ 4^ 4^ 4^ 4^ 4^ 4^ 4^ 4^ 4^ 4^ 4^ 4^ 4^ 4^ 4^ 4^ 4^ 4^ 4^ 4^ 4^ fa a a SO SO SO SO SO 00 00 00 00 00 00 00 00 00 00 •o •o •o •o •o •o •o •o •o •o Os Os Is (O 4^ LJ K> O SO 00 •ο os LAI 4^ LJ K) o SO 00 •o Os LAI 4^ LJ K) O SO 00 r r r r r r r r r Kj r Kj r Kj r r r Kj r Kj r r r Kj r Kj r Kj r Kj r Kj r Kj r Kj r Kj r Kj r Kj s LAi £ LAi s LAi s LAi £ LAI s LAI s LAI s LAI £ LAI £ LAI £ LAI s LAI s LAI S 4^ S 4^ s 4^ £ 4^ S 4^ S 4^ £ 4^ S 4^ S 4^ £ K> S K> S K) S K) S K) X LJ X K> X K> LJ X K> K> ffi K> ffi K> O ffi SO ffi 00 ffi LAI ffi 4^ E LJ ffi •o ffi os ffi Os ffi LAI X ffi O X SO X 00 X K) X •o X Os X LAI ffi 4^ X 00 X •o X Os 3 a CA! o tn CTQ o 3 00 CA! Os 4^ CTQ CA! o tn CTQ l-j 4^ po i—‘ CAl K> ¥L· K> CTQ CA! £ CTQ s o ^ § 1-^ ft p° (TO ft σ' CA! o i-t ! o 3 1? CA! O i-t ! o 3 £ © so •p o' o CTQ σ' •o os ® ο o 3 g N* O CTQ σ' 00 ^ 3 N* ft CTQ σ' O <1 o ft" 1 CA! CTQ σ' os H-00 os I—1-n or CA! O c= CTQ σ' LJ K> O ft 3 o CA! SO CTQ •o ^ σ' 1-t P3 O -1^ s 3' σ' ft" tncrQ LAi LAI LJ ·<! 1 ft rro" σ' os 4^ CA! o tn CTQ o 3 LJ CA! LAI LJ rjq sorghum 09vl SBOj 000920 o' ft CTQ σ' •o Lh^ ο o 3 P N* ft CTQ σ' 00 o 3 N* ft CTQ σ' 4^ -J O o ft 3 o o| k) 21 σ' 1-t P3 o -1^ s ON & Ό S' σ' fS — v; W (TO Μ σ' LJ LAi 00 -O 1 ft £ rro" σ' ^ Os ^ 4^ CA! o tn CTQ o 3 OS CA! VO ^ SO CTQ CA! o i-t ! ο B 2 o fo iP 3. ft" <? "o O 5> o JL K> --o W oo <f 4^ LAI 3 P N* ft CTQ σ' ^ 00 o rt S 5¾ >8 κ> σ' Os •o ►n lj σ' Os •o ►n 'o σ, ω n > O — 00 tn o O — 00 tn o 00 o K> o 4^ ω ο κ> Os LAI > •o 00 LJ tn O LJ SO o H Os 00 os Os tn tn 2 3 SO 00 c/t 23 O ^ r w tn tn 4^ 4^ 4^ lj σ' os •o 'n oo o LAI o % o LAI > Os O O ° os OS tn s 2o 3 LAi (^, SO no in ^ o r w « g LJ oo σ' os •o ►n LAI oo tn o i K> K) & I r •o tn Os ό o Os Os LAI K> SO 4^ SO LAI LAI o SO SO r •o O SO 4^ 4^ SO SO o 00 o Os 00 tn Os o ns 4^ SO K> K> o o SO SO SO SO SO SO SO SO SO SO SO SO SO SO SO SO SO SO SO SO SO SO SO SO SO o o SO SO SO SO SO SO SO SO SO SO 00 00 00 00 00 00 00 00 00 00 •o •o •o •o •o o SO 00 •o Os LAI 4^ LJ K> o SO 00 •o os LAI 4^ LJ K> o SO 00 •o Os LAI - K> K> K> K> K> K> K> K> K> K> K> K> K> K> K> K) K) K) K) K) K> K> K) K> K) K) K) omol SEQ NO: 4^ 4^ 4^ 4^ 4^ 4^ 4^ 4^ 4^ 4^ 4^ 4^ 4^ 4^ 4^ 4^ 4^ 4^ 4^ 4^ 4^ 4^ 4^ 4^ 4^ 4^ 4^ 4^ 4^ 4^ 4^ 4^ 4^ 4^ 4^ 4^ 4^ 4^ 4^ 4^ LJ LJ LJ LJ LJ LJ LJ LJ LJ SO SO SO SO 00 00 SO SO SO 00 00 oo SO SO SO 00 00 LJ 00 SO 00 00 00 LJ 00 00 00 00 00 00 & »Q £* 1° LAI LJ LJ <1 o SO © LJ p] bo 1° LAI 1° o SO LAi bo LJ o SO LJ LJ k> P K) 4^ K) !o LAI LAI o LAI LJ SO SO p bs bs p bs 11 ^ σ' σ' σ' σ' σ' σ' σ' σ' σ' σ' CT1 σ' σ' σ' σ' σ' σ' σ' σ' σ' σ' σ' CT1 σ' σ' σ' σ' P P P P P P P P P cr? CA! CA! CA! CA! CA! CA! CA! CA! CA! CA! CA! CA! CA! CA! CA! CA! CA! CA! CA! CA! CA! CA! CA! CA! CA! CA! CA! © S' S' >8 2016213786 11 Aug 2016 62 Nucl. SEQ ID NO: Gene Name cluster name Polyp. SEQ ID NO: Homolog. to SEQ ID NO: % global identity Algor. 495 LYM5 H14 wheat|gbl64|BE41473 3 2002 244 90.6 blastp 496 LYM5 HI5 wheat|gbl64|BE43102 6 2003 244 91.3 blastp 497 LYM5 HI6 wheat|gb 164|CA61338 0 2004 244 90.9 blastp 498 LYM7 H35 b oleracea|gbl 61 |AM05 7184 2005 246 81.2 blastp 499 LYM7 H36 barley gb 157 SOLEXA IBE413128 2006 246 82.6 blastp 500 LYM7 H37 barley gb 157 SOLEXA IBF627706 2007 246 95.7 blastp 501 LYM7 H38 brachypodium 09vl D V468966 2008 246 94.2 blastp 502 LYM7 H39 brachypodium 09vl D V474806 2009 246 82.6 blastp 503 LYM7 H6 bruguiera gb 166 BP94 5554 2010 246 81.2 blastp 504 LYM7 H40 canola|gbl61|CD8116 53 2011 246 81.2 blastp 505 LYM7 H41 canola|gb 161 |CD83 84 23 2012 246 81.2 blastp 506 LYM7 H42 cassava|09vl|CK6523 48 2013 246 82.6 blastp 507 LYM7 H43 castorbean 09vl XMO 02532394 2014 246 82.6 blastp 508 LYM7 H44 cucumber 09vl AM71 7859 2015 246 82.6 blastp 509 LYM7 H9 eucalyptus gb 166 CB9 67858 2016 246 81.2 blastp 510 LYM7H10 kiwi|gbl66|FG431017 2017 246 81.2 blastp 511 LYM7H11 kiwi|gbl66|FG521634 2018 246 82.6 blastp 512 LYM7 H12 liriodendron| gb 16 61F D 494835 2019 246 82.6 blastp 513 LYM7 H45 maize|gbl70|AI94390 8 2020 246 82.6 blastp 514 LYM7 H46 maize|gbl70|AW2822 44 2021 246 88.4 blastp 515 LYM7 H47 maize|gbl70|LLAI855 232 2022 246 82.61 tblastn 516 LYM7 H48 maize|gbl70|LLDN20 9190 2023 246 82.61 tblastn 517 LYM7 H49 millet 09vlEVO454P M003641 2024 246 91.3 blastp 518 LYM7 H50 millet 09vlEVO454P M019125 2025 246 81.2 blastp 519 LYM7H16 oat|gbl64|CN817490 2026 246 88.4 blastp 520 LYM7H17 oat|gbl64|CN819643 2027 246 82.6 blastp 521 LYM7 H51 poplar|gb 170|BI06944 6 2028 246 81.2 blastp 522 LYD97 H18 poplar|gbl70|BI12366 2 2029 246 81.2 blastp 2016213786 11 Aug 2016 63 Nucl. SEQ ID NO: Gene Name cluster name Polyp. SEQ ID NO: Homolog. to SEQ ID NO: % global identity Algor. 523 LYM7 H20 rye|gbl64|BE496021 2030 246 94.2 blastp 524 LYM7 H21 rye|gbl64|BE587226 2031 246 81.2 blastp 525 LYM7 H52 sorghum 09vl SB05G 003875 2032 246 88.4 blastp 526 LYM7 H53 sugarcane gbl57.3 CA 079082 2033 246 89.9 blastp 527 LYM7 H54 sugarcane gbl57.3 CA 158782 2034 246 81.2 blastp 528 LYM7 H25 switchgrass gb167 DN 149707 2035 246 82.6 blastp 529 LYM7 H26 switchgrass gbl 67 FE6 44021 2036 246 84.1 blastp 530 LYM7 H27 switchgrass gb 167 FE6 57215 2037 246 80 blastp 531 LYM7 H28 switchgrass gb 167 FE6 58413 2038 246 88.4 blastp 532 LYM7 H29 switchgrass gbl67 FL6 89692 2039 246 88.4 blastp 533 LYM7 H30 wheat|gbl64|BE40435 0 2040 246 81.2 blastp 534 LYM7 H31 wheat|gbl64|BE41437 1 2041 246 84.1 blastp 535 LYM7 H32 wheat|gbl64|BE43001 7 2042 246 94.2 blastp 536 LYM7 H33 wheat|gbl64|BE44405 8 2043 246 95.7 blastp 537 LYM7 H34 wheat|gbl64|BE44478 9 2044 246 82.6 blastp 538 LYM7 H35 wheat|gbl64|CA59836 3 2045 246 95.7 blastp 539 LYM8 H7 arabidopsis lyrata|09vl |JGIAL008 627 2046 247 80.2 blastp 540 LYM8 H8 arabidopsis lyrata|09vl |JGIAL021 400 2047 247 83.3 blastp 541 LYM8 HI arabidopsis gb 165 AT 3G03110 2048 247 80.6 blastp 542 LYM8 H2 arabidopsis gb 165 AT 5G17020 2049 247 82.9 blastp 543 LYM8 H9 brachypodium 09vl G T774368 2050 247 95.6 blastp 544 LYM8H10 castorbean|09vl |EE25 5045 2051 247 84.2 blastp 545 LYM8H11 che stnut gb 17 0 S RR0 0 6295S0059698 2052 247 85.7 blastp 546 LYM8 H12 cucumber 09v 1 GD17 4631 2053 247 84.5 blastp 547 LYM8H13 lotus|09vl|BP043858 2054 247 83.8 blastp 548 LYM8 H14 lotus 09vlBP071708 2055 247 83.6 blastp 549 LYM8H15 maize|gbl70|AA03070 9 2056 247 92.1 blastp 2016213786 11 Aug 2016 LAi LAI LAi LAi LAI LAI LAI LAI LAI LAI LAI LAI LAI LAI LAI LAI LAI LAI LAI LAI LAI LAI LAI LAI fa a •o •o •o •o Os os os os os os os os os os LAI LAI LAI LAI LAI LAI LAI LAI LAI LAI Is to U> IO o SO 00 •o os LAI 4^ U) to O SO 00 •o os LAI 4^ Ό to o r r r r r r r r r r r r r r C5 r _ r _ r _ r _ r _ r _ r X 3 £ £ £ X H< ^ s X H< ^ s X H< £ s ffi N< IO o ^ ffi N< to o ^ ffi N< to >-> o ^ £ £ S S S S S S S S S s s SO 00 00 00 00 00 00 00 00 00 00 00 00 o X X X IO H- o o Ο H- o SO H-o 00 H- o Ό H- o X K ffi to ffi •o Os to to to to to K a K K s' S SO 00 •o LAI 4^ Ό to o SO 00 •o os artemisia|gb 164|EX 0216 arabidopsis gb 165 5G50460 arabidopsis gb 165 4G24920 arabidopsis gb 165 3G48570 arabidopsis lyrata|09vl |JGIAL 470 arabidopsis lyrata|09vl |JGIAL 614 arabidopsis lyrata|09vl |JGIAL 989 £ Ή, θΓ CTQ σ' to ^ n 2 00 •o £ Ή, θΓ CTQ σ' U) ^ n 2 4^ 00 £ Ή, θΓ CTQ σ' O 2 4^ 4^ antirrhinum | gb 16 61 86992 O o SO SO δ to 4^ 3 o o SO 00 ^ "5 O to soybean gbl68 BE 809 soybean gbl68 BE 102 sorghum 09vl SBC 009800 sorghum 09vl SBC 000490 | 28228 solanum phurej a 09v 1 SPHBi o' o CTQ σ' •o 00^ ο o 00 o Ό O Ό o CTQ σ' o W C 00 Ό O Ό CTQ σ' 4^ O O Cd to medicago 09v 1 BM 9128 medicago 09vl BE 102 3 N* a CTQ σ' tO Ό o > OS to cluster name > > > O O O 4^ SO U) > LAI 00 00 to to o Os •o to SO IO IO •o SO LAI to to o O U-) 4^ •o 4^ Ό o LAI 00 H H H SO LAI •o SO os to SO to Ό LAI O SO 4^ Ό LAi to IO IO IO IO IO IO IO to to to to to to to to to to to to to to to to to 5 o o o o o O o o o o O o o o O o o o o o o O O O 00 •o •o •o •o •o •o •o Ο •o o os os os OS os os os os os OS LAI LAI LAI o SO 00 •o os LAI 4^ U) to o SO 00 •o Os LAI 4^ Ό to O SO 00 •o - δ^3 S' IO IO IO IO IO IO IO to to to to to to to to to to to to to to to to to omol SEQ NO: 4^ 4^ 4^ 4^ 4^ 4^ 4^ 4^ 4^ 4^ 4^ 4^ 4^ 4^ 4^ 4^ 4^ 4^ 4^ 4^ 4^ 4^ 4^ 4^ SO SO SO SO SO SO SO SO SO SO SO 00 •o •o Ο Ό Ο Ο •o •o Ο Ο Ο Ο 00 SO SO 00 SO SO 00 87 SO SO 00 00 00 Ό U) Ό 00 82.98 89 SO 00 99.72 85 00 00 00 SO & 00 u> u> LAi LAi U) U) LAi LAI U) U) SO SO © bs Ό SO Ό to p bo Ό SO Ό LAI to to 11 ^ σ' σ' σ' σ' σ' σ' σ' σ' σ' σ' σ' σ' σ1 σ' σ1 σ' σ' σ' σ1 σ' σ' σ' σ' σ' P P P P P P P P P P P cr? CA! CAl CAl CAl CAl CAl CAl CAl ζΛ CAl CAl ζΛ ζΛ ζΛ ζΛ CAl CAl CAl ζΛ CAl CAl CAl CAl CAl © S' S S >8 2016213786 11 Aug 2016 65 Nucl. SEQ ID NO: Gene Name cluster name Polyp. SEQ ID NO: Homolog. to SEQ ID NO: % global identity Algor. 574 LYM10 HI 1 b juncea gbl 64 EVGNO 0323614690486 2081 249 85.5 blastp 575 LYM10 H12 b juncea gbl 64 EVGNO 0357611620134 2082 249 81.16 tblastn 576 LYM10 H13 b juncea gbl 64 EVGNO 0407015981886 2083 249 91.3 blastp 577 LYM10 H14 b juncea gbl 64 EVGNO 1046711722157 2084 249 91.3 blastp 578 LYM10 H15 b juncea gbl 64 EVGNO 1350404310247 2085 249 91.3 tblastn 579 LYM10 H16 b juncea gbl 64 EVGNO 1826229072660 2086 249 91.3 blastp 580 LYM10 H17 b juncea gbl 64 EVGN1 0412810992898 2087 249 86.3 blastp 581 LYM10 H18 b juncea gbl 64 EVGN1 9578802581818 2088 249 81.2 blastp 582 LYM10 H19 b oleracea|gbl 61 |AM05 9639 2089 249 91.3 blastp 583 LYM10 H20 b oleracea|gb 161 |EH414 574 2090 249 91.3 blastp 584 LYM10 H21 b oleracea|gb 161 |EH427 198 2091 249 81.7 blastp 585 LYM10 H22 b rapa|gbl62|BG544908 2092 249 91.3 blastp 586 LYM10 H23 b rapa|gbl62|DY010003 2093 249 91.3 blastp 587 LYM10 H24 b rapa|gbl62|EE524434 2094 249 91.3 tblastn 588 LYM10 H25 b rapa|gbl62|L35825 2095 249 91.3 blastp 589 LYM10 H26 banana|gbl67|DN2397 48 2096 249 94.2 blastp 590 LYM10 H27 banana|gbl67|ES4325 17 2097 249 95.7 blastp 591 LYM10 H28 banana|gbl67|FL6497 89 2098 249 95.7 blastp 592 LYM10 H29 banana|gbl67|FL6581 61 2099 249 94.2 blastp 593 LYM10 H213 barley gb 157 SOLEXA IAJ433765 2100 249 100 blastp 594 LYM10 H214 barley gb 157 SOLEXA IBE412470 2101 249 100 blastp 2016213786 11 Aug 2016 66 Nucl. SEQ ID NO: Gene Name cluster name Polyp. SEQ ID NO: Homolog. to SEQ ID NO: % global identity Algor. 595 LYM10 H215 barley gb 157 SOLEXA IBF254576 2102 249 98.6 blastp 596 LYM10 H216 barley gb 157 SOLEXA IBF257015 2103 249 100 blastp 597 LYM10 H34 beangbl67 CA907476 2104 249 92.75 tblastn 598 LYM10 H35 beangbl67 CA907483 2105 249 94.2 blastp 599 LYM10 H217 beech gb 170 SRR0062 93S0011456 2106 249 92.8 blastp 600 LYM10 H218 beech gb 170 SRR0062 94S0008365 2107 249 88.4 blastp 601 LYM10 H219 brachypodium 09vl D V469126 2108 249 100 blastp 602 LYM10 H220 brachypodium 09vl G T803631 2109 249 92.8 blastp 603 LYM10 H38 bruguiera gb 166 BP94 1922 2110 249 95.7 blastp 604 LYM10 H39 bruguiera gb 166 BP94 4773 2111 249 95.7 blastp 605 LYM10 H40 cacao|gbl67|CU47152 9 2112 249 94.2 blastp 606 LYM10 H41 cacao|gbl67|CU48059 7 2113 249 84.1 blastp 607 LYM10 H42 cacao gbl67CU49329 8 2114 249 89.9 blastp 608 LYM10 H43 canola|gbl61|CD8132 31 2115 249 91.3 tblastn 609 LYM10 H44 canola|gbl61|CD8175 28 2116 249 91.3 tblastn 610 LYM10 H45 canola|gb 161 |CD8200 75 2117 249 91.3 tblastn 611 LYM10 H46 canola|gb 161 |CD8242 39 2118 249 91.3 tblastn 612 LYM10 H47 canola|gb 161 |CD83 80 62 2119 249 86.3 blastp 613 LYM10 H48 canola|gbl61|CD8408 08 2120 249 91.3 blastp 614 LYM10 H49 canola|gbl61|CN7324 34 2121 249 91.3 tblastn 615 LYM10 H50 canola|gb 161 |DW9992 88 2122 249 91.3 blastp 616 LYM10 H51 canola|gbl61|EE43417 6 2123 249 84.1 blastp 617 LYM10 H52 canola|gb 161 |EE46403 6 2124 249 87 blastp 618 LYM10 H221 cassava|09vl|CK6422 25 2125 249 94.2 blastp 619 LYM10 H222 cassava 09vl DV4557 17 2126 249 94.2 blastp 620 LYM10 H223 cassava 09v 1 FF3 803 8 9 2127 249 94.2 blastp 621 LYM10 H224 castorbean|09vl |EG66 4279 2128 249 92.8 blastp 2016213786 11 Aug 2016 67 Nucl. SEQ ID NO: Gene Name cluster name Polyp. SEQ ID NO: Homolog. to SEQ ID NO: % global identity Algor. 622 LYM10 H225 castorbean 09vl XMO 02509459 2129 249 91.3 blastp 623 LYM10 H58 c atharanthus | gb 1661E G560643 2130 249 91.3 blastp 624 LYM10 H59 c atharanthus | gb 16 61FD 416462 2131 249 91.3 blastp 625 LYM10 H60 c atharanthus | gb 16 61 FD 420164 2132 249 92.8 blastp 626 LYM10 H61 centaurea|gbl66|EH74 7070 2133 249 87 blastp 627 LYM10 H62 centaurea|gbl66|EH78 8831 2134 249 89.9 blastp 628 LYM10 H226 chestout gb 170 SRRO0 6295S0002470 2135 249 95.7 blastp 629 LYM10 H227 che stout gb 170 S RRO 0 6295S0013318 2136 249 92.8 blastp 630 LYM10 H228 cichorium gb 171 FL67 3304 2137 249 85.51 tblastn 631 LYM10 H63 citrus|gbl66|CF41752 0 2138 249 91.3 blastp 632 LYM10 H64 coffeagbl57.2 DV666 460 2139 249 91.3 blastp 633 LYM10 H65 coffeagbl57.2 DV676 797 2140 249 89.86 tblastn 634 LYM10 H66 cotton gb 164 BE05219 8 2141 249 94.2 blastp 635 LYM10 H67 cotton gbl 64 BQ4048 33 2142 249 95.7 blastp 636 LYM10 H68 cotton|gbl64|BQ4074 07 2143 249 92.8 blastp 637 LYM10 H69 cotton gb 164 CK6405 93 2144 249 95.7 blastp 638 LYM10 H70 cotton gbl64 DT05275 9 2145 249 88 blastp 639 LYM10 H71 cotton gbl64 DT57406 1 2146 249 80.7 blastp 640 LYM10 H72 cowpea gb 166FF3865 43 2147 249 94.2 blastp 641 LYM10 H73 cowpea gb 166 FF3 893 57 2148 249 94.2 tblastn 642 LYM10 H74 cryptomeria|gb 1661 BP 174192 2149 249 89.9 blastp 643 LYM10 H75 cryptomeria|gb 1661 BP 174931 2150 249 88.6 blastp 644 LYM10 H229 cucumber 09vl AM71 5093 2151 249 88.41 tblastn 645 LYM10 H230 cucumber 09vl AM72 0495 2152 249 98.6 blastp 646 LYM10 H231 cucumber 09vl DN90 9507 2153 249 95.7 blastp 647 LYM10 H76 cycas gbl66 CB09149 9 2154 249 88.4 blastp 648 LYM10 H77 cynaragbl67 GE5892 84 2155 249 88.4 blastp 2016213786 11 Aug 2016 68 Nucl. SEQ ID NO: Gene Name cluster name Polyp. SEQ ID NO: Homolog. to SEQ ID NO: % global identity Algor. 649 LYM10 H78 dandelion gb 161 DY 8 11008 2156 249 88.41 tblastn 650 LYM10 H79 dandelion gb 161 DY 8 39599 2157 249 89.86 tblastn 651 LYM10 H80 eucalyptus gb 166 CD6 69252 2158 249 92.8 blastp 652 LYM10 H232 fern gb 171 DK961389 2159 249 88.4 blastp 653 LYM10 H81 fescue gbl61DT7022 92 2160 249 100 tblastn 654 LYM10 H82 fescue gbl61DT7044 58 2161 249 100 tblastn 655 LYM10 H233 flax|09vl|EU829193 2162 249 92.8 blastp 656 LYM10 H234 gerbera|09vl|AJ76119 3 2163 249 89.9 blastp 657 LYM10 H235 gerbera|09v 11AJ76591 3 2164 249 84.1 blastp 658 LYM10 H83 ginger|gbl64|DY3684 24 2165 249 95.65 tblastn 659 LYM10 H84 ginger|gbl64|DY3821 25 2166 249 94.2 blastp 660 LYM10 H85 grape|gbl60|BQ79355 2 2167 249 91.3 blastp 661 LYM10 H86 grape|gbl60|CA80999 7 2168 249 91.3 blastp 662 LYM10 H87 iceplant|gbl64|AI9434 23 2169 249 88.4 blastp 663 LYM10 H88 ipomoea|gbl57.2|BJ55 3479 2170 249 89.86 tblastn 664 LYM10 H89 ipomoea gbl 57.2 CB3 29955 2171 249 88.41 tblastn 665 LYM10 H90 ipomoea gbl57.2 CJ75 1960 2172 249 88.4 blastp 666 LYM10 H236 jatropha|09vl |G02476 49 2173 249 94.2 blastp 667 LYM10 H91 kiwigbl66 FG397070 2174 249 89.9 blastp 668 LYM10 H92 kiwi|gbl66|FG477805 2175 249 95.7 blastp 669 LYM10 H93 lettuce gbl57.2 DW04 7717 2176 249 88.4 blastp 670 LYM10 H94 lettuce gbl57.2 DW05 1281 2177 249 89.9 blastp 671 LYM10 H95 lettuce gbl57.2 DW08 0235 2178 249 82.61 tblastn 672 LYM10 H96 lettuce gbl57.2 DW10 1958 2179 249 88.4 blastp 673 LYM10 H97 lettuce gbl57.2 DW12 3456 2180 249 88.41 tblastn 674 LYM10 H237 liquorice |gb 171 |FS242 287 2181 249 94.2 blastp 675 LYM10 H98 liriodendron| gb 16 61F D 495465 2182 249 95.7 blastp 2016213786 11 Aug 2016 69 Nucl. SEQ ID NO: Gene Name cluster name Polyp. SEQ ID NO: Homolog. to SEQ ID NO: % global identity Algor. 676 LYM10 H99 liriodendron| gb 16 61F D 500844 2183 249 94.2 blastp 677 LYM10 H238 lolium| 09v 11AU24781 9 2184 249 98.6 blastp 678 LYM10 H239 lotus 09vlCB827059 2185 249 92.8 blastp 679 LYM10 H240 lotus|09vl|DN652280 2186 249 89.9 blastp 680 LYM10 H102 lovegrass gbl67DN48 2980 2187 249 98.6 blastp 681 LYM10 H241 maize|gbl70|AI00134 0 2188 249 97.1 blastp 682 LYM10 H242 maize|gbl70|AI66551 2 2189 249 98.6 blastp 683 LYM10 H243 maize gb 170 AI67719 5 2190 249 97.1 blastp 684 LYM10 H244 maize | gb 17 01LLAI619 401 2191 249 97.1 blastp 685 LYM10 H245 maize|gbl70|LLCF003 156 2192 249 81.16 tblastn 686 LYM10 H246 maize | gb 17 01LLDQ24 5943 2193 249 98.6 blastp 687 LYM10 H247 maize|gbl70|W21637 2194 249 98.6 blastp 688 LYM10 H109 marchantia|gbl66|BJ8 44102 2195 249 87 blastp 689 LYM10 H248 medicago|09vl|AA660 461 2196 249 94.2 blastp 690 LYM10 H249 medicago 09vl AW28 7868 2197 249 94.2 blastp 691 LYM10 H250 medicago 09v 1 LLBQ 138650 2198 249 85.5 blastp 692 LYM10 H112 melon gb 165 AM 7150 93 2199 249 94.2 tblastn 693 LYM10 H113 melon gbl65 AM7204 95 2200 249 98.55 tblastn 694 LYM10 H114 melon|gbl65|DV6317 10 2201 249 95.7 blastp 695 LYM10 H251 millet 09vlCD724432 2202 249 98.6 blastp 696 LYM10 H252 monkeyflower|09vl |D V208117 2203 249 91.3 blastp 697 LYM10 H116 nuphar|gbl66|CD4725 02 2204 249 97.1 blastp 698 LYM10 H253 oak gbl70 SRR006307 S0013335 2205 249 94.2 blastp 699 LYM10 H254 oak gbl70 SRR006307 S0023745 2206 249 92.75 tblastn 700 LYM10 H117 oil palm|gbl66|EL684180 2207 249 92.8 blastp 701 LYM10 H118 onion gbl62 BQ58014 8 2208 249 97.1 blastp 702 LYM10 H119 papaya gbl 65 EX2792 51 2209 249 89.9 blastp 2016213786 11 Aug 2016 70 Nucl. SEQ ID NO: Name cluster name Polyp. SEQ ID NO: Homolog. to SEQ ID NO: % global identity Algor. 703 LYM10 H255 peanut|gbl71|EE1245 30 2210 249 94.2 blastp 704 LYM10 H256 peanut|gbl71|EE1266 80 2211 249 94.2 blastp 705 LYM10 H257 peanut|gbl 71 |EG0288 25 1111 249 81.2 blastp 706 LYM10 H258 pe anut gbl71EG3739 93 2213 249 94.2 blastp 707 LYM10 H259 pepper gb 171 CA5166 79 2214 249 91.3 blastp 708 LYM10 H260 pepper gbl71 GD0537 70 2215 249 89.9 blastp 709 LYM10 H261 petunia gbl71 AF0499 33 2216 249 87 blastp 710 LYM10 H262 petunia gbl71 EB1743 81 2217 249 87 blastp 711 LYM10 H263 physcomitrella| 1 Ον 11A W145358 2218 249 81.2 blastp 712 LYM10 H264 physcomitrella| 1 Ον 1 |B G361572 2219 249 81.2 blastp 713 LYM10 H133 pine|gbl57.2|AL75081 3 2220 249 91.3 blastp 714 LYM10 H134 pine|gbl57.2|AW0648 95 1111 249 91.3 blastp 715 LYM10 H135 pine|gbl57.2|AW2264 88 mi 249 89.9 blastp 716 LYM10 H265 poplar|gbl70|BI12774 5 mi 249 92.8 blastp 111 LYM10 H266 poplar|gbl70|BU8241 90 2224 249 92.8 blastp 718 LYM10 H267 poplar|gbl70|BU8626 32 Ills 249 92.8 blastp 719 LYM10 H139 poppy gbl66 FE96500 9 2226 249 88.4 blastp 720 LYM10 H140 poppy gbl66 FE96643 0 2227 249 92.8 blastp 111 LYM10 H141 potato|gbl57.2|BG350 890 2228 249 91.3 blastp 111 LYM10 H142 potatogbl57.2 BG589 211 2229 249 89.86 tblastn 111 LYM10 H143 potato gbl57.2 BG592 598 2230 249 89.86 tblastn 724 LYM10 H144 potato|gbl57.2|BQ516 058 2231 249 91.3 blastp 725 LYM10 H145 prunus gbl67 BU0395 66 mi 249 92.8 blastp 726 LYM10 H146 prunus gbl67 BU0467 83 mi 249 87 blastp 111 LYM10 H147 radish|gbl64|EV52635 4 2234 249 91.3 tblastn 728 LYM10 H148 radish|gbl64|EV52839 0 2235 249 91.3 blastp 729 LYM10 H149 radish|gbl64|EV53627 3 2236 249 91.3 blastp 2016213786 11 Aug 2016 71 Nucl. SEQ ID NO: Name cluster name Polyp. SEQ ID NO: Homolog. to SEQ ID NO: % global identity Algor. 730 LYM10 H150 radish|gbl64|EV54575 1 2237 249 91.3 tblastn 731 LYM10 H151 radish|gbl64|EV54872 1 2238 249 91.3 blastp 732 LYM10 H152 radish|gbl64|EV55048 8 2239 249 91.3 blastp 733 LYM10 H153 radish|gbl64|EV56739 7 2240 249 85.5 blastp 734 LYM10 H154 radish| gb 164 |E W 7134 25 2241 249 89.9 blastp 735 LYM10 H155 radish|gbl64|FD57055 9 2242 249 89.9 blastp 736 LYM10 H268 rice gb 170 OS06G443 74 2243 249 95.7 blastp 737 LYM10 H157 rose gbl57.2 BI97819 8 2244 249 91.3 tblastn 738 LYM10 H158 rose|gbl57.2|EC58984 2 2245 249 92.75 tblastn 739 LYM10 H159 safflower gbl62 EL39 3855 2246 249 88.41 tblastn 740 LYM10 H160 safflower|gbl62|EL51 1136 2247 249 89.9 blastp 741 LYM10 H269 senecio gbl70 C0553 399 2248 249 88.4 blastp 742 LYM10 H161 sesame gbl57.2 BU66 9069 2249 249 91.3 tblastn 743 LYM10 H270 solanum phurej a| 09v 11SPHAI4 83617 2250 249 89.9 blastp 744 LYM10 H271 solanum phurej a| 09v 11SPHBG1 27130 2251 249 91.3 blastp 745 LYM10 H272 sorghum 09v 1 SB04G 005280 2252 249 98.6 blastp 746 LYM10 H273 sorghum 09v 1 SB 1OG 026000 2253 249 97.1 blastp 747 LYM10 H164 soybean|gbl68|AA660 461 2254 249 94.2 blastp 748 LYM10 H165 soybean gbl68 AW47 2512 2255 249 92.8 blastp 749 LYM10 H166 soybean gbl 68 BU544 187 2256 249 94.2 blastp 750 LYM10 H167 spikemoss gbl65DN8 38422 2257 249 85.51 tblastn 751 LYM10 H168 spruce gb 162 C02169 79 2258 249 91.3 blastp 752 LYM10 H169 spruce gb 162 C02170 20 2259 249 91.3 blastp 753 LYM10 H170 spurge gb 161 DV1126 55 2260 249 84.1 blastp 754 LYM10 H171 spurge gbl61DV1202 63 2261 249 86.5 blastp 755 LYM10 H172 strawberry gb 164 C03 80171 2262 249 91.3 tblastn 2016213786 11 Aug 2016 72 Nucl. SEQ ID NO: Name cluster name Polyp. SEQ ID NO: Homolog. to SEQ ID NO: % global identity Algor. 756 LYM10 H173 strawberry|gbl 64|EX6 64646 2263 249 92.8 blastp 757 LYM10 H274 sugarcane gbl57.3 CA 072778 2264 249 97.1 blastp 758 LYM10 H275 sugarcane gbl57.3 CA 087927 2265 249 98.6 blastp 759 LYM10 H276 sugarcane gbl57.3 CA 103056 2266 249 98.6 blastp 760 LYM10 H177 sunflower gb 162 BUO 15373 2267 249 89.86 tblastn 761 LYM10 H178 sunflower gb 162 CD8 49625 2268 249 88.4 blastp 762 LYM10 H179 sunflower gb 162 CD8 51122 2269 249 88.41 tblastn 763 LYM10 H180 switchgrass gb 167 DN 145554 2270 249 98.6 blastp 764 LYM10 H181 switchgrass gbl 67 FE6 33347 2211 249 97.1 blastp 765 LYM10 H182 switchgrass gb 167 FE6 39131 2212 249 98.6 blastp 766 LYM10 H183 switchgrass gb 167 FL7 20694 2273 249 95.7 blastp 767 LYM10 H184 tamarix | gb 16 61EG9 6 8 743 2274 249 85.5 blastp 768 LYM10 H185 tamarix | gb 16 61EG9 69 152 2275 249 88.4 blastp 769 LYM10 H277 teagbl71 FF682807 2276 249 95.7 blastp 770 LYM10 H186 thellungiella| gb 16 71BI 698898 2277 249 91.3 blastp 111 LYM10 H187 thellungiella gb 16 7 EC 599088 2278 249 91.3 blastp 111 LYM10 H188 tobacco gbl62 CV020 564 2279 249 81.8 blastp 773 LYM10 H189 tobacco gbl62 CV021 149 2280 249 80.8 blastp 774 LYM10 H190 tobacco gbl62 CV021 577 2281 249 91.3 tblastn 775 LYM10 H191 tobacco|gbl62|EB426 093 2282 249 91.3 tblastn 776 LYM10 H192 tobacco|gbl62|EB447 225 2283 249 89.9 blastp 111 LYM10 H278 tomato| 09v 11AI483617 2284 249 89.9 blastp 778 LYM10 H279 tomato|09vl|BG12713 0 2285 249 91.3 tblastn 779 LYM10 H195 triphysaria|gbl 64|EX9 88147 2286 249 81.6 blastp 780 LYM10 H196 walnuts gbl66 CB304 079 2287 249 98.6 blastp 781 LYM10 H197 wheat|gbl64|BE42322 6 2288 249 100 tblastn 782 LYM10 H198 wheat|gbl64|BE42385 8 2289 249 100 tblastn 2016213786 11 Aug 2016 00 00 00 00 00 00 00 00 00 •o •o •o •o •o •o •^1 •o •o •o •o •o •o •o •ο •o •o fa a a ο o o o o o o o o VO VO VO VO VO VO VO VO VO VO 00 00 00 00 00 00 00 Is to 00 •o Ov LAI 4^ u> K> o VO 00 •o Ov LAI 4^ L*J K> o VO 00 •o ov LAI 4^ U) r r r r r r r r r r C5 r r r r r r r _ r _ r _ r _ r _ r _ r _ r _ r _ r X ^ a ^ s a ^ x ^ s x ^ s s s a ^ x ^ s s s s s M ^ £ g ov 2 4^ LAI 2 K 2 4^ P 4^ s s U) ^ 4^ 4^ 4^ K 2 K> ^ £ g 4^ L*J L*J L*J L*J O ^ •o n— O ^ OV H— O ^ LAI H- o ^ 4^ n— O ^ L*J H- O ^ K) n— O ^ O ^ O n— VO S VO n— 4^ 4^ X 4^ 4^ X 4^ X X X 4^ 4^ X K E E E o o O O O o O o o s 00 •o 4^ L»J K> L*J LAI 4^ L*J o O S' 3 CTQ σ' 2jE cichoriumgbl 88253 centaurea|gbl6 2821 castorbean|09'v 9029 cassava 09vlCK65' 18 canola|gb 161 |DY 02 85 brachypodium T76284 artemisia|gbl6 4514 e σ' & LAI o Γ) O LAI 00 CTQ κ> σ' 3 σ' ol L*J O 21. ,__i CA!* LO rjQ κ> σ' arabidopi lyrata|09vl|JG 254 arabidopi lyrata|09vl|JG 556 aquilegiagbl5' 27713 switchgrass gb 34401 sorghum 09vl 04995C 3 s N* ft CTQ σ' •o o H K) Ov brachypodium T79448 1 ft po rro" σ' Ch g o 1 ft S- (jcT σ' Ch g o 1 ft po rro" σ' Ch g n 1 ft po rro" σ' ^ 4^ n wheat|gbl64|BI479! 5 1 ft po rro" σ' ίχ Ον ^ 4^ ω 1 ft po rro" σ' td 1 ft po rro" σ' [x Ov ^ 4^ a 1 ft S- cro~ σ' a rt s &a >8 Si LAi •o Ή ffi Ov ON a X w O o VO w ο παν LAI > ο παν LAI > r o r o ^4 U) O OV •o 00 W o 00 0 VO & •o L*J •o > Ov K) •<1 > Ov VO > Ov VO ►Π 4^ •Ο 4^ 4^ •o L*J tn Ov O 4^ tn 4^ 4^ LAI I VO VO •o Ov LAI O O 4^ Ov "S O U) H H K> o o VO VO tn Ov b "S K) o L*J VO Ov L*J LAI VO 00 4^ 00 00 L*J U) K> K> K> K> K> K> K> K> K> K> K> K> K> K) K) K) K> K) K) K> K) K) κ> K) K) K> U) u> U) U) U) u> u> U) U) U) U) U) L*J L*J L*J L*J K) K) K) K> K) K> Κ) K) K) K) H— H— h— h— H— H— o o o o o o o O O O VO VO VO VO VO VO νο VO VO VO LAI 4^ u> K> o VO 00 •o OV LAI 4^ L*J K) O VO 00 •o OV LAI 4^ L*J K) o - δ^3 S' E K> K> K> K> K> K> K> K> K> K> K> K> K) K) K> K> K) K> K> K) K) K) Κ) K) K) K) omol SEQ NO: LAi LAi LAi LAI LAI LAI LAI LAI LAI LAI LAI LAI LAI LAI LAI LAI LAI 4^ 4^ 4^ 4^ 4^ 4^ 4^ 4^ 4^ K> K> K> K> K> K> K> K> K> K> K> K) K> H— H— H— H— VO VO VO VO VO VO VO VO VO 00 o 00 o 00 o 00 o 00 o 00 VO 00 00 o 00 o 00 o 00 o 00 00 4^ 00 4^ 00 4^ 00 o 00 LAI 00 L*J VO 00 ov VO 00 νο 00 VO 00 VO 00 % global identity U) <1 4^ U) 4^ 4^ 4^ LAI L*J LAI LAI ov LAI bo u> VO ov LAI LAI LAi LAI o LAI LAI LAI LAI σ; σ; S’" σ; S’" σ; <σ S’" σ; S’" σ; S’" σ; S’" σ; S’" σ; S’" <σ σ; & σ; & σ; σ; <σ S' <σ σ; <σ σ; σ; σ; σ; σ; σ; σ; <s$ CA! CA! >£f CA! CA! CA! CA! CA! CA! CA! 0 CA! CA! >8 2016213786 11 Aug 2016 74 Nucl. SEQ ID NO: Gene Name cluster name Polyp. SEQ ID NO: Homolog. to SEQ ID NO: % global identity Algor. 809 LYM14 H37 cucumber 09v 1 DN91 0737 2316 252 80.75 tblastn 810 LYM14 H12 ginger|gbl64|DY3589 76 2317 252 83.3 blastp 811 LYM14 H13 iceplant|gbl64|AI8228 35 2318 252 80.75 tblastn 812 LYM14 H14 lettuce gbl57.2 DW15 8376 2319 252 82.3 tblastn 813 LYM14 H15 leymus gbl66 CD8091 80 2320 252 95 blastp 814 LYM14 H38 maize|gbl70|AI78326 0 2321 252 93.8 blastp 815 LYM14 H39 maize|gbl70|AI94167 5 2322 252 95.1 blastp 816 LYM14 H18 melon| gb 1651AM7137 63 2323 252 80.5 tblastn 817 LYM14 H40 monkeyflower|09vl |G 0959633 2324 252 80.12 tblastn 818 LYM14 H41 monkeyflower|09vl |G R111000 2325 252 80.12 tblastn 819 LYM14 H19 papaya|gbl65|EX2611 25 2326 252 81.1 blastp 820 LYM14 H20 radish| gb 164 |E W7236 81 2327 252 81.37 tblastn 821 LYM14 H42 solanum phurej a| 09v 11SPHBG6 28013 2328 252 80.1 blastp 822 LYM14 H43 sorghum 09v 1 SBO1G 038730 2329 252 96 blastp 823 LYM14 H44 sorghum| 09v 11SB02G 044050 2330 252 86 blastp 824 LYM14 H23 soybean gb 168 AW56 0935 2331 252 80.1 blastp 825 LYM14 H25 spikemoss gbl65 FE43 4307 2332 252 81.06 tblastn 826 LYM14 H45 sugarcane gbl57.3 CA 079818 2333 252 84.2 blastp 827 LYM14 H46 sugarcane gbl57.3 CA 150518 2334 252 93.85 tblastn 828 LYM14 H29 sunflower gb 162 EL4 8 4937 2335 252 80.75 tblastn 829 LYM14 H30 switchgrass gb 167 DN 143407 2336 252 95.4 blastp 830 LYM14 H47 tomato|09vl|BG62801 3 2337 252 80.1 blastp 831 LYM14 H31 wheat|gbl64|BE41600 3 2338 252 83.6 blastp 832 LYM15 H4 brachypodium 09vl D V476162 2339 253 80.2 blastp 833 LYM15 H2 pseudoroegneria gb 16 7IFF343970 2340 253 82 blastp 834 LYM15 H3 wheat|gbl64|BE21329 5 2341 253 81.4 blastp 2016213786 11 Aug 2016 00 00 00 00 00 00 00 00 00 00 00 00 00 00 00 00 00 00 oo 00 00 00 00 00 00 00 00 fa a a os os LAi LAI LAI LAI LAI LAI LAI LAI LAI LAI 4L 4L 4^ 4^ 4^ 4^ 4^ 4^ 4^ 4^ LJ LJ LJ LJ LJ Is to o SO 00 •ο Os LAI 4L LJ K> O SO 00 •o Os LAI 4^ LJ K> o SO 00 •o Os LAI r r r r r E E E E E E E E E E E E E E C5 e e E E E o E E E 3 £ £ £ E 3 £ £ E 3 E ^ s s s s s s s s s s s E 3 E 3 s E 3 s S E- ^ E- ^ E- 2 ο ρ SO SO SO K> ^ SO SO O P •o •o •o •o •o •o OS OS OS OS OS K> ^ SO SO os O P OS LAI SO E E E SO E E SO SO E E E E E E E E E E E OS OS E os E E s SO 00 •o LAI LJ os LAI 4L LJ •o os SO 00 •o Os LAI LJ SO 4L 1 ft po άο" σ' 1 ft po rro" σ' 1 po rro" σ' to 2 CA! 1. o σ' CTQ o 3 LJ CAl LAI O CTQ sorghum 09vl 00999C Ό CA! ft σ -j 9* M o σι i-t 3| ft" 1 CA! CTQ σ' 4L H- •O Os σ' 1-t σ o s ·<] O-o\ g‘ σ' S ciT τ-ϋ ί> (TO E E O '-'J on 1 ft po fro" σ' 00 E 1 ft po rro" σ' [x Os ^ 4L 1 ft S- rro" σ' 1 ft S- rro" σ' σ, e sugarcane gbl: 152022 σ' — v; W (TO W Έ o ΙΌ ^ 1 ft po rro" σ' 1 ft po rro" σ' os 4^ 1 ft S- cro~ σ' os 4^ ft CTQ σ' os 4^ tn n? CA! ft 0= M o •“Tj E{ 3| 3 g N* ft CTQ σ' On LJ 3 P N* ft CTQ σ' •o ^ o O o SO os £, 1-¾ ft^ CA! O c= ft CTQ σ' o ^ σ' E{ P3 O s •<1 O- LAi g· σ' — v; W (TO W σ' fo cn 1 ft S- rro" σ' ω ξ rt s &a >8 td td dd •ο σ' K 2 u> 3 LJ C/t « td td td ON ΕΛ td td td tn £ 2 E Cd E >. E 3 cn ΕΛ td c Os tn LAI tn LJ Os •o 00 td ^ 3· CTn tn O ^ O SO ON O E o tn 4L tn 4L tn 4L cn Q ^ E tn 4^ tn 4^ tn K> 4^ SO \c> n. S _£L r 'n c K) O H •<1 o SO ® o r tn 4L I •o 00 SO CTQ LJ tn v o SO K) O tn 1—k 1—k 1—k CTQ E N4 4^ Os tn SO K> LAi 00 σι σ' 00 LJ O SO Os n 00 Os Os σ' K> Os Os OJ SO os tn o e^ •o o n •o K> LAI C O SO LAI 00 E^ o C 00 K> •o SO os K> > SO o os > > •o 00 4^ •o > LJ K> K> K> K> K> K> K> K> K> K> K) K) K) K> K) K> K) K> K) K) K) K) K) K) K> K) K) OJ LJ LJ LJ LJ LJ LJ LJ LJ LJ LJ LJ LJ LJ LJ LJ LJ LJ LJ LJ LJ LJ LJ LJ LJ LJ LJ Os Os Os Os Os Os Os Os Os LAI LAI LAI LAI LAI LAI LAI LAI LAI LAI 4^ 4^ 4^ 4^ 4^ 4L 4L 4L 00 •o Os LAI 4L LJ K> O SO 00 •o os LAI 4^ LJ K> O SO 00 •o Os LAI 4L LJ K> ·· s^3 S' E K> K> K> K> K> K> K> K> K> K> K) K) K> K) K) K) K) K> K) K) K> K) K) K> K> K) K) omol SEQ NO: LAI LAi LAI LAI LAI LAI LAI LAI LAI LAI LAI LAI LAI LAI LAI LAI LAI LAI LAI LAI LAI LAI LAI LAI LAI LAI LAI Os Os Os os Os Os Os Os Os LAI LAI LAI LAI LAI LAI 4^ 4^ 4^ 4^ 4^ 4^ 4^ 4^ 4^ 4L 4L LJ 00 86.28 00 00 00 00 00 00 86 00 00 00 00 00 00 SO SO SO SO SO 00 00 00 SO SO SO 00 & »Q E 1° LJ Os 1° bs os SO p bo •o fo LAi bs OS 4L LAi bs LAi bs p LJ LJ LJ LAI o SO LAI lo 4^ 1° K> SO p LJ SO 1° O SO 4L 11 ^ σ' σ1 σ' σ' σ' σ' σ' σ' σ' σ' σ' σ' σ' σ' σ' σ' σ' σ' σ1 σ' σ1 σ' σ' σ' σ' σ' σ' P P σ σ σ σ σ σ σ σ σ σ σ σ cr? CA! CA! CA! CA! CA! CA! CA! CA! CA! CA! CA! CA! CA! CA! CA! CA! CA! CA! CA! CA! CA! CA! CA! CA! CA! CA! CA! © 3~ >8 00 00 00 00 00 00 00 00 00 00 00 00 00 00 00 00 00 00 00 00 00 00 00 00 00 00 00 fa a a 00 00 00 00 00 00 00 00 00 •o —J •o •o •o •o •o •o •o •o os os os os os os os os is to 00 •o os LAI 4^ u> K> o SO 00 •o os LAI 4^ u> K) o SO 00 •o os LAI 4^ L*J K> r r r r r r r r r r r r r r r r r r r r r r r r r r r K 3 a ^ a 3 a ^ a ^ a ^ a ^ £ a ^ £ £ £ £ a ^ a ^ a ^ S S S £ a ^ a ^ S a ^ a ^ a ^ S LO g ^ ?0 £ £ K> LO g W ?0 U) S £ s K> K> ° M K> K> K> K> 00 to K) K> K> o K> o £ £ K> 1- s K> o £ s K) S S ° K) K) o a a a a a a a a a o o a O o o a S SO 00 •o Os LAI K> SO 00 LAI SO sorghum 09v 1 SB06G 027500 sorghum| 09v 11SB02G 006170 rice gbl70 OS02G473 20 pineapple gbl 57.2 CO 731607 millet 09vlEVO454P M000947 millet 09vlEVO454P M000432 maize|gbl70|AI58645 9 lovegrass gbl67DN48 0337 lolium|09vl|AU25028 8 leymus gbl 66 CN4657 70 kiwi|gbl66|FG405276 fescue gbl61DT6806 31 cenchrus|gbl66|EB655 115 brachypodium 09vl G T760558 brachypodium 09vl D V488150 barley gb 157 SOLEXA IBE437461 banana|gb 167|FF5594 48 banana|gbl67|FF5574 36 wheat|gbl64|BE41198 2 switchgrass gbl 67 FE6 54910 sugarcane gbl57.3 CA 072511 sorghum 09v 1 SBO1G 009140 pseudoroegneria gb 16 7IFF343142 maize|gbl70|AI85723 6 castorbean 09vl XMO 02519056 brachypodium 09vl D V479896 barley gb 157 SOLEXA IAL450927 cluster name K> K> K> K> K> K> K> K> K> K> K> K> K> K> K> K) K> K> K> K) K> K> K) K> K> K> K) 5 u> U) U) U) U) U) U) U) u> u> U) U) U) U) U) U) U) L*J L*J L*J L*J L*J L*J L*J L*J L*J L*J SO SO SO SO SO SO 00 00 00 00 00 00 00 00 00 00 •o •o •o •o •o •o •o •o •o •o Os LAI 4^ U) K> o SO 00 •o os LAI 4^ u> K> o SO 00 •o Os LAI 4^ L*J K) o SO - s· a K> K> K> K> K> K> K> K> K> K> K> K> K> K> K> K> K> K) K> K) K> K) K) K> K) K) K> omol SEQ NO: LAI LAI LAI LAI LAI LAI LAI LAI LAI LAI LAI LAI LAI LAI LAI LAI LAI LAI LAI LAI LAI LAI LAI LAI LAI LAI LAI 00 00 00 00 00 00 00 00 00 00 00 00 00 00 00 00 00 00 •o •o •o •o •o •o •o •o •o SO SO 87.27 82.73 SO SO SO SO 90 00 00 90 SO SO SO 00 00 00 00 00 00 00 89 SO 80 00 00 & £* LAi LAi u> Os bo LAi LAI u> os 1° 00 lo bo bo pi U) LAi LAI 00 !o o SO o SO 00 os 4^ LAI L*J SO SO p p OS l*j 11 ^ cr cr CT1 CT1 cr cr cr cr cr cr cr cr cr cr cr cr cr cr cr cr cr cr cr cr cr cr cr P P P P P P P ¢5 P P P cr? CA! CAl CA! CA! CA! CA! CAl CAl CAl CAl CAl CAl CAl CAl CAl CAl CAl CAl CAl CAl CA! CA! CA! CA! CA! CA! CA! © S' S >8 2016213786 11 Aug 2016 2016213786 11 Aug 2016 77 Nucl. SEQ ID NO: Gene Name cluster name Polyp. SEQ ID NO: Homolog. to SEQ ID NO: % global identity Algor. 889 LYM21 H37 sugarcane gbl57.3 BQ 529660 2396 258 93.6 blastp 890 LYM21 H38 sugarcane gbl57.3 BQ 535381 2397 258 92.7 blastp 891 LYM21 H39 sugarcane gbl57.3 CA 118830 2398 258 87.3 blastp 892 LYM21 H19 switchgrass gb167 DN 151016 2399 258 93.6 blastp 893 LYM21 H20 switchgrass gb 167 FL7 22429 2400 258 94.5 blastp 894 LYM21 H21 switchgrass gb 167 FL9 36988 2401 258 95.5 blastp 895 LYM21 H22 tobacco| gb 1621AM791 579 2402 258 88.2 blastp 896 LYM21 H23 wheat|gbl64|BE35263 2 2403 258 89.1 blastp 897 LYM21 H24 wheat|gbl64|BE40279 2 2404 258 89.1 blastp 898 LYM21 H25 wheat|gbl64|BE49257 5 2405 258 89.09 tblastn 899 LYM21 H26 wheat|gbl64|CA48457 5 2406 258 94.5 blastp 900 LYM21 H27 wheat|gbl64|CA61660 9 2407 258 92.73 tblastn 901 LYM24 HI fescue gbl61DT6811 71 2408 261 80.61 tblastn 902 LYM24 H2 leymus gbl66 CD8086 23 2409 261 80.5 blastp 903 LYM24 H8 maize |gb 170|AI62144 0 2410 261 81 blastp 904 LYM24 H9 pseudoroegneria gb 16 7IFF349814 2411 261 80 blastp 905 LYM24 H10 sorghum 09v 1 SB03G 044280 2412 261 83.1 blastp 906 LYM24 HI 1 sugarcane gbl57.3 CA 072633 2413 261 82.6 blastp 907 LYM24 H6 switchgrass gb 167 DN 144637 2414 261 84.6 blastp 908 LYM24 H7 switchgrass gb 167 DN 145452 2415 261 85.6 blastp 909 LYM24 H8 wheat|gbl64|BE42590 0 2416 261 80 tblastn 910 LYM26 HI wheat|gbl64|BE39890 3 2417 262 88.6 blastp 911 LYM30 H5 brachypodium 09v 1 S RR031799S0073966 2418 263 86.5 blastp 912 LYM30 H6 maize|gbl70|AW5201 85 2419 263 85.8 blastp 913 LYM30 H7 maize|gbl70|AW9276 89 2420 263 85 blastp 914 LYM30 H8 rice gbl70 OS11G025 80 2421 263 99.2 blastp 915 LYM30 H9 rice gbl70 OS12G025 10 2422 263 87.7 blastp 2016213786 11 Aug 2016 78 Nucl. SEQ ID NO: Gene Name cluster name Polyp. SEQ ID NO: Homolog. to SEQ ID NO: % global identity Algor. 916 LYM30 H10 sorghum 09v 1 SB05G 001250 2423 263 86.1 blastp 917 LYM30 H5 switchgrass gbl67 FL7 96240 2424 263 80.16 tblastn 918 LYM31 HI rice gbl70 OS12G027 10 2425 264 97.9 blastp 919 LYM35 H5 brachypodium 09v 1 S RR031798S0189278 2426 267 80 blastp 920 LYM35 H6 maize|gbl70|BM4168 80 2427 267 89.7 blastp 921 LYM35 H7 sorghum 09v 1 SB06G 031730 2428 267 86.7 blastp 922 LYM35 H8 sugarcane gbl57.3 CA 105471 2429 267 87.5 blastp 923 LYM35 H4 switchgrass gb 167 FL9 39819 2430 267 89.9 blastp 924 LYM35 H5 wheat|gbl64|BE50050 4 2431 267 86.1 blastp 925 LYM42 HO rice gbl70 OS01G411 20 2432 273 96.7 blastp 925 LYM42 HO rice gbl70 OS01G411 20 2432 439 99.83 tblastn 926 LYM43 HI rice gbl70 OS12G028 00 2433 274 91.4 blastp 927 LYM52 HI b rapa|gbl62|EX068270 2434 277 94.5 blastp 928 LYM52 H2 fescue gb 161 CK8028 23 2435 277 84.4 blastp 929 LYM52 H3 leymus gb 16 6 EG3 794 66 2436 277 96.3 blastp 930 LYM52 H10 maize|gbl70|BE 13009 4 2437 277 80 blastp 931 LYM52 HI 1 maize|gbl70|LLBE05 6010 2438 277 81 blastp 932 LYM52 H12 rice gbl70 OS04G517 92 2439 277 81.4 blastp 933 LYM52 H13 sorghum 09v 1 SB06G 027870 2440 277 82.5 blastp 934 LYM52 H14 sugarcane gbl57.3 AA 577629 2441 277 84.47 tblastn 935 LYM52 H8 switchgrass gb167 DN 147335 2442 277 82.65 tblastn 936 LYM52 H9 wheat gbl 64 BG90925 9 2443 277 94.5 blastp 937 LYM52 H10 wheat gbl 64 BG90949 3 2444 277 95.1 blastp 938 LYM56 H9 brachypodium 09v 1 S RR031795S0049724 2445 279 85.9 blastp 939 LYM56 H10 maize|gbl70|AI71195 4 2446 279 80.14 tblastn 940 LYM56 H2 pseudoroegneria gb 16 7IFF341776 2447 279 87.9 blastp 941 LYM56 HI 1 rice gbl70 OS03G457 20 2448 279 80.1 blastp 2016213786 11 Aug 2016 79 Nucl. SEQ ID NO: Gene Name cluster name Polyp. SEQ ID NO: Homolog. to SEQ ID NO: % global identity Algor. 942 LYM56 H12 sorghum 09v 1 SBO1G 012840 2449 279 81 blastp 943 LYM56 H13 sugarcane gbl57.3 BQ 533995 2450 279 80.14 tblastn 944 LYM56 H6 switchgrass gb 167 FE6 31693 2451 279 84.5 blastp 945 LYM56 H7 switchgrass gb 167 FL7 82747 2452 279 83.1 blastp 946 LYM56 H8 wheat|gbl64|BE40420 7 2453 279 88.7 blastp 947 LYM56 H9 wheat gbl 64 CD91296 3 2454 279 87.8 blastp 948 LYM57 HO brachypodium 09vl D V475724 2455 280 81.1 blastp 949 LYM62 HI sorghum 09v 1 SB 10G 012150 2456 282 88.9 blastp 950 LYM66 HI wheat|gbl64|BE40393 2 2457 283 83 blastp 950 LYM66 HI wheat|gbl64|BE40393 2 2457 440 83 blastp 951 LYM66 H2 wheat|gbl64|BE40540 9 2458 283 90.4 blastp 951 LYM66 H2 wheat|gbl64|BE40540 9 2458 440 90.4 blastp 952 LYM66 H3 wheat|gbl64|CA60026 3 2459 283 90.1 blastp 952 LYM66 H3 wheat|gbl64|CA60026 3 2459 440 90.1 blastp 953 LYM69 HO rice gbl70 OS07G425 20 2460 286 98.3 blastp 954 LYM73 H6 brachypodium 09vl D V481090 2461 287 95.8 blastp 955 LYM73 H7 maize|gbl70|AW2561 55 2462 287 93.7 blastp 956 LYM73 H8 sorghum 09vlSB07G 004300 2463 287 94.3 blastp 957 LYM73 H9 sugarcane gbl57.3 CA 117425 2464 287 94.3 blastp 958 LYM73 H5 switchgrass gb167 DN 145973 2465 287 94.6 blastp 959 LYM73 H6 wheat|gbl64|AF28925 7S1 2466 287 92.67 tblastn 960 LYM79 H3 brachypodium 09v 1 S RR031800S0005207 2467 289 83.8 blastp 961 LYM79 H4 millet 09vlEVO454P M011117 2468 441 82.72 tblastn 962 LYM79 H5 sorghum 09v 1 SB 10G 012140 2469 289 93 blastp 962 LYM79 H5 sorghum 09v 1 SB 10G 012140 2469 441 93.75 tblastn 963 LYM79 HI switchgrass gbl67 FE5 98528 2470 289 90.6 blastp 963 LYM79 HI switchgrass gbl67 FE5 98528 2470 441 91.1 tblastn 2016213786 11 Aug 2016 80 Nucl. SEQ ID NO: Gene Name cluster name Polyp. SEQ ID NO: Homolog. to SEQ ID NO: % global identity Algor. 964 LYM79 H2 switchgrass gbl 67 FL9 57870 2471 441 86.6 tblastn 965 LYM79 H3 wheat|gbl64|BE59051 8 2472 289 80 blastp 965 LYM79 H3 wheat|gbl64|BE59051 8 2472 441 83.33 tblastn 966 LYM82 HI banana|gbl67|FF5619 62 2473 290 82.1 blastp 967 LYM82 H12 brachypodium 09vl G T816645 2474 290 94.1 blastp 968 LYM82 H2 leymus gb 16 6 EG3 840 73 2475 290 97.9 blastp 969 LYM82 H13 maize|gbl70|AW1811 52 2476 290 90.6 blastp 970 LYM82 H4 melon|gbl 65|AM7182 13 2477 290 80.21 tblastn 971 LYM82 H14 millet 09vlEVO454P M002754 2478 290 82.99 tblastn 972 LYM82 H5 pseudoroegneria gb 16 7IFF352234 2479 290 99 blastp 973 LYM82 H15 rice gb 170 OS06G044 60 2480 290 91 blastp 974 LYM82 H16 sorghum 09v 1 SB 10G 002420 2481 290 90.3 blastp 975 LYM82 H8 soybean gbl 68 CA921 223 2482 290 80.21 tblastn 976 LYM82 H17 sugarcane gbl57.3 BU 102729 2483 290 90.3 blastp 977 LYM82 H10 switchgrass gb 167 FL7 44837 2484 290 89.6 blastp 978 LYM82 HI 1 wheat|gbl64|BE40384 2 2485 290 99 blastp 979 LYM82 H12 wheat|gbl64|CA66078 8 2486 290 99 blastp 980 LYM83 H8 brachypodium 09v 1 S RR031797S0009670 2487 291 86.5 blastp 980 LYM83 H8 brachypodium 09v 1 S RR031797S0009670 2487 442 86.1 blastp 981 LYM83 H9 lolium|09vl|ES699086 2488 291 84.84 tblastn 981 LYM83 H9 lolium|09vl|ES699086 2488 442 84.43 tblastn 982 LYM83 H10 maize|gbl70|AI66534 7 2489 291 82.4 blastp 982 LYM83 H10 maize|gbl70|AI66534 7 2489 442 82.4 blastp 983 LYM83 H3 pseudoroegneria gb 16 7IFF354990 2490 291 97.5 blastp 983 LYM83 H3 pseudoroegneria gb 16 7IFF354990 2490 442 97.1 blastp 984 LYM83 HI 1 rice gbl70 OS05G453 00 2491 291 81.6 blastp 984 LYM83 HI 1 rice gbl70 OS05G453 00 2491 442 81.1 blastp 2016213786 11 Aug 2016 81 Nucl. SEQ ID NO: Gene Name cluster name Polyp. SEQ ID NO: Homolog. to SEQ ID NO: % global identity Algor. 985 LYM83 H12 sorghum 09v 1 SB09G 026370 2492 291 82 blastp 985 LYM83 H12 sorghum 09v 1 SB09G 026370 2492 442 81.6 blastp 986 LYM83 H6 switchgrass gb167 DN 149383 2493 291 84 blastp 986 LYM83 H6 switchgrass gb167 DN 149383 2493 442 83.6 blastp 987 LYM83 H7 wheat|gbl64|BE51671 5 2494 291 94.7 blastp 987 LYM83 H7 wheat|gbl64|BE51671 5 2494 442 94.3 blastp 988 LYM83 H8 wheat|gbl64|BF42868 8 2495 291 95.1 blastp 988 LYM83 H8 wheat|gbl64|BF42868 8 2495 442 94.7 blastp 989 LYM84 H8 brachypodium 09v 1 S RR031795S0021840 2496 292 92.8 blastp 990 LYM84 H9 maize|gbl70|AW2821 61 2497 292 82.8 blastp 991 LYM84 H10 maize | gb 17 01LLDQ24 5778 2498 292 98.7 blastp 992 LYM84 H4 pseudoroegneria gb 16 7IFF355744 2499 292 98.3 blastp 993 LYM84 HI 1 rice gbl70 OS03G416 12 2500 292 84.58 tblastn 994 LYM84 H12 sorghum 09v 1 SB01G 014640 2501 292 82.9 blastp 995 LYM84 H7 switchgrass gbl67 FE6 52995 2502 292 81.3 blastp 996 LYM84 H8 wheat|gbl64|BE41769 7 2503 292 95.1 blastp 997 LYM88 HO arabidopsis lyrata|09vl | JGIAL014 996 2504 294 91.5 blastp 998 LYM89 H5 arabidopsis lyrata|09vl |JGIAL031 299 2505 295 86.36 tblastn 999 LYM89 H2 canola|gbl61|CD8120 18 2506 295 81.8 blastp 1000 LYM89 H3 canola|gb 161 |CD8218 97 2507 295 81.8 blastp 1001 LYM89 H4 radish|gbl64|EW7327 98 2508 295 81.65 tblastn 1002 LYM89 H5 radish|gbl64|EX74970 2 2509 295 80.7 blastp 1003 LYM90 H3 brachypodium 09vl D V488904 2510 296 83.2 blastp 1004 LYM90 H2 wheat|gb 164|BQ24215 1 2511 296 94.6 blastp 1005 LYM90 H3 wheat|gbl64|BQ24492 2 2512 296 94.6 blastp 1006 LYM91 HI rye|gbl64|BE494176 2513 297 82.5 blastp 2016213786 11 Aug 2016 1033 1032 1031 1030 1029 1028 1027 1026 1025 1024 1023 1022 1021 1020 1019 1018 1017 1016 1015 1014 1013 1012 1011 1010 1009 O O OO 1007 Nuc/. SEQ ID NO: LYM110 HI LYM106 H8 LYM106 H7 LYM106 H6 LYM106 H5 LYM106 H4 LYM106 H3 LYM106 H9 LYM106 H8 LYM105 H5 LYM105 H4 LYM105 H3 LYM105 H2 LYM105 H5 LYM103 H2 LYM103 H3 LYM103 H2 LYM100 HI LYM99 H2 LYM99 H2 LYM93 H5 LYM93 H4 LYM93 H3 LYM93 H2 LYM93 HI LYM91 H3 LYM91 H2 Gene Name sugarcane gbl57.3 CA 204413 wheat|gbl64|BF48509 8 wheat|gbl64|BE44526 4 wheat|gbl64|BE44319 5 spruce gbl62DR5435 63 rye|gbl64|BE586535 pseudoroegneria gb 16 7IFF347837 maize | gb 17 01LLDQ24 5927 brachypodium 09vl D V476632 wheat|gb 164|BQ743 87 5 wheat|gbl64|BE63793 6 wheat|gbl64|BE40533 0 pseudoroegneria gb 16 7IFF366339 barley gb 157 SOLEXA IBQ461657 switchgrass gbl 67 FL8 77864 sugarcane gbl57.3 CA 078686 sorghum|09v 1 |SB03G 004410 wheat|gbl64|BE39903 6 wheat|gbl64|AL81899 0 brachypodium 09vl D V482533 wheat gb 164 C J92017 1 wheat|gbl64|CA67840 5 wheat|gbl64|CA62407 1 wheat|gbl64|BE41804 7 wheat|gbl64|BE40153 5 wheat|gbl64|CA59311 2 wheat|gbl64|BE40065 9 cluster name 2540 2539 2538 2537 2536 2535 2534 2533 2532 2531 2530 2529 2528 2527 2526 2525 2524 2523 2522 2521 2520 2519 2518 2517 2516 2515 2514 Polyp. SEQ ID NO: 306 305 305 305 305 305 305 305 305 304 304 304 304 304 303 303 303 301 299 299 298 298 298 298 298 297 297 Homolog. to SEQ ID NO: 00 p U) 97.2 97.9 96.5 84.72 90.3 96.5 97.9 00 © <1 89.4 91.8 90 90.5 90.9 87 89.69 89.69 89.5 ΖΓΡ6 86.8 88.7 94.55 84.6 93.6 93.6 86.27 85.4 % global identity tblastn blastp blastp blastp tblastn blastp blastp blastp blastp blastp blastp blastp blastp blastp blastp tblastn tblastn blastp tblastn blastp blastp tblastn blastp blastp blastp tblastn blastp Algor. 2016213786 11 Aug 2016 83 Nucl. SEQ ID NO: Gene Name cluster name Polyp. SEQ ID NO: Homolog. to SEQ ID NO: % global identity Algor. 1034 LYM111 H7 brachypodium 09vl G T765731 2541 307 80.96 tblastn 1035 LYM111 HI cenchrus|gbl66|EB657 665 2542 307 87.6 blastp 1036 LYM111 H8 maize|gbl70|AI94154 5 2543 307 89.9 blastp 1037 LYM111 H9 rice gbl70 OS01G570 66 2544 307 81.5 blastp 1038 LYM111 H10 sorghum 09v 1 SB03G 036350 2545 307 91.5 blastp 1039 LYM111 HI 1 sorghum 09v 1 SB05G 023720 2546 307 93.1 tblastn 1040 LYM111 H12 sugarcane gbl57.3 CA 072460 2547 307 89.38 tblastn 1041 LYM111 H7 switchgrass gbl67 FL7 11377 2548 307 90.8 blastp 1042 LYM119 HI sorghum 09vl SB05G 003680 2549 308 93.8 blastp 1043 LYM122 HI brachypodium 09vl D V469739 2550 310 84.5 blastp 1044 LYM122 HI pseudoroegneria gb 16 7IFF350527 2551 310 82.53 tblastn 1045 LYM129 H2 brachypodium 09v 1 S RR031795S0005798 2552 315 80.4 blastp 1046 LYM129 H3 maize|gbl70|BQ48626 9 2553 315 82.8 blastp 1047 LYM129 H4 sorghum 09vl SB03G 044510 2554 315 81.6 blastp 1048 LYM129 H2 switchgrass gbl67 FE6 43628 2555 315 80.6 blastp 1049 LYM130 HI leymusgbl66 EG3779 85 2556 316 80.2 blastp 1050 LYM130 H2 rice gbl70 OS05G043 80 2557 316 99.4 blastp 1051 LYM130 H2 wheat|gbl64|BE41476 7 2558 316 80.8 blastp 1052 LYM131 HI aquilegia gbl57.3 DR9 17618 2559 317 81.2 blastp 1053 LYM131 H13 barley gb 157 SOLEXA IAL450948 2560 317 83 blastp 1054 LYM131 H14 brachypodium 09vl D V479902 2561 317 85.3 blastp 1055 LYM131 H15 maize|gbl70|AI86132 7 2562 317 90.8 blastp 1056 LYM131 H16 maize|gbl70|AW1298 26 2563 317 82.8 blastp 1057 LYM131 H17 maize|gbl70|AW4531 72 2564 317 91.7 blastp 1058 LYM131 H18 rice gbl70 OS08G127 50 2565 317 85.1 blastp 1059 LYM131 H19 sorghum 09v 1 SB06G 027970 2566 317 91.5 blastp 1060 LYM131 H20 sorghum 09v 1 SB07G 006320 2567 317 81 blastp 2016213786 11 Aug 2016 ft S © PS ο o o O o o o o o o o o o o o o o o o o o o o o 00 00 00 00 00 •o •o •o •o •o •o •o •o •o •o OS OS OS OS OS os OS OS os (O 4^ LJ K> o SO 00 •o OS LAI 4L LJ K) o SO 00 •o Os LAI 4L LJ K> r r r r r r r r r r r r r r r r r r r r r r r r YM13 H223 Ss Ss Ss Ss si Ϊ5 si YM13 H222 YMl H22] YMl H22( 5s x ^ £ £ x ^ £ £ YMl H5 YMl H4 Kj X g YMl H2 YMl HO 5s si 5s X ^ K) ^ •Ο H- os H- LAi H- 4^ H- LJ H-‘ K> H- Ο H- 'Ό ω °° ω ^ OJ LJ H-‘ K> H- LJ LJ LJ LJ LJ LJ LJ LJ w LO LJ LJ LJ LJ LJ LJ LJ LJ LJ LJ •ο •o •o •o •o •o •o •o •o •o •o •o •o •o •o •o •o •o •o 4L g ίο' ι-t ^ o si οϊ O o § o o 1 σ' TO £ TO £ TO § I Ό | 2 3 § |] si § s 00 c 2 3 1 1-t^ o' o 1 o CA! CA! CA! 0= CTQ P O SO <C LJ •O _P3_ L/l ffQ έ t ό on cr lo ct i= ja ^ (TO 2 ^ £ cr 1= ft 00 sa J-') (TO LO Cj- to ^ cr £ CL O 3¾ £ CL o 2¾ nisiagbl 583] ε LJ O rs to LAi £2. LAI CA! ¢0 Ο 3 SO P ^ < σ' SO — CL ο n so < cr -= ^ ο n so < cr = & CTQ K) SO CTQ LAi cT CTQ cr 00 CTQ cr CTQ cr OJ ^ o i-i <T LAI 00 _^_ ^ CTQ CTQ cr •o ο o CTQ cr £ CTQ o 3 00 CA! VO ^ CTQ o 3 •o CA! o ^ rcanegbl57. 068895 rs ^*1 S 5¾ >8 LAI S 00 2 OS 4L n ^ ON 4^ n σ\ ^ o td o td o SO H- — — — 4^ (TO to (TO ^ CTQ lai cr 4^ CTQ K> CTQ s H o Os to W ,¾ <! σ\ -= to W o <| o -= to W £ < Os 4L tn O oo <T Ο H- Os Ο ό HH CA! 00 ^· UJ ^ 00 ^· UJ ^ SO LAi •o o O O 4l cr Os 4l cr Os lai cr Os Os Os oo o 4L dd w 4^ cr Os os cr Os S2 S SO 4^ o K> rs ^°§ °°§ < 4L Os o SO SO LAI > r o 4L K) os 4L o 00 o H so 00 00 SO o 4L LAI LJ Os > Os > Os > o O LAI os K> K) •o τη f •o Td tn LJ O •o o o o O LAI LJ H LAI o K> •o 00 LJ •o •o •o •o SO LAI •o Os > K> K> K> K> K> K> K> K> K> K> K) K) K> K) K) K) K> K> K) K> K) K> K> K) LAl LAi LAi LAi LAI LAI LAI LAI LAI LAI LAI LAI LAI LAI LAI LAI LAI LAI LAI LAI LAI LAI LAI LAI SO SO 00 00 00 00 00 00 00 00 00 00 •o •o •o •o •o •o •o •o •o •o Os Os o SO 00 •o os LAI 4L LJ K) o SO 00 •o Os LAI 4L LJ K) o SO 00 - δ^3 S' LJ LJ LJ LJ LJ LJ LJ LJ LJ LJ LJ LJ LJ LJ LJ LJ LJ LJ LJ LJ LJ LJ LJ LJ omol SEQ NO: K> K> K> K> K> K> K> K> K) K) K) K) K) K) K) K) K> K> K> SO •o •o •o •o 00 00 00 00 00 00 85 00 00 00 00 00 00 00 00 83.01 00 LJ 00 00 SO 00 SO 00 SO & »Q k> k> k> LJ bo 4L bs LAi LJ k> p LAI p LAI bo 1° bo K) 4L LJ LAI 0C bo LJ 4^ SO LAi 11 $ fa <r cr cr cr cr cr cr cr cr cr cr cr cr cr cr r1 cr cr cr cr cr cr cr cr P P P P P P cr? CA! CA! CA! CA! CA! CA! CA! CA! CA! CA! CA! CA! CA! CA! CA! CA! CA! CA! CA! CA! CA! CA! CA! CA! © S' >8 2016213786 11 Aug 2016 85 Nucl. SEQ ID NO: Gene Name cluster name Polyp. SEQ ID NO: Homolog. to SEQ ID NO: % global identity Algor. 1085 LYM137 H18 b olerace a| gb 1611 AM 3 9 2244 2592 321 81.2 blastp 1086 LYM137 H19 b olerace a|gb 161 |DY 014 383 2593 321 83.8 blastp 1087 LYM137 H20 b olerace a|gb 161 |DY 023 491 2594 321 83.8 blastp 1088 LYM137 H21 b olerace a|gb 161 |DY 023 494 2595 321 81.2 blastp 1089 LYM137 H22 b olerace a|gb 161 |DY 027 443 2596 321 81.2 blastp 1090 LYM137 H23 b oleracea|gbl61|EE535 717 2597 321 80.5 blastp 1091 LYM137 H24 b rapa|gbl62|BG543640 2598 321 83.77 tblastn 1092 LYM137 H25 b rapa|gbl62|BQ791808 2599 321 80.5 blastp 1093 LYM137 H26 b rapa| gb 162 |C A991997 2600 321 81.2 blastp 1094 LYM137 H27 b rapa|gbl62|CV432555 2601 321 81.2 blastp 1095 LYM137 H28 b rapa|gbl62|CV432912 2602 321 81.2 blastp 1096 LYM137 H29 b rapa|gbl62|CV432918 2603 321 83.8 blastp 1097 LYM137 H30 b rapa|gbl62|CX267185 2604 321 81.2 blastp 1098 LYM137 H31 b rapa|gbl62|CX271342 2605 321 81.2 blastp 1099 LYM137 H32 banana|gbl67|DN2395 14 2606 321 85.7 blastp 1100 LYM137 H33 banana|gbl67|ES4316 62 2607 321 86.4 blastp 1101 LYM137 H34 banana|gbl67|FF5581 02 2608 321 85.7 blastp 1102 LYM137 H35 banana|gbl67|FF5587 29 2609 321 86.4 blastp 1103 LYM137 H36 banana|gbl67|FF5608 01 2610 321 85.7 blastp 1104 LYM137 H37 banana|gbl67|FL6573 44 2611 321 85.8 blastp 1105 LYM137 H38 basilicum gb 157.3 DY 342616 2612 321 80.5 blastp 1106 LYM137 H39 beangbl67 CA897728 2613 321 85 blastp 1107 LYM137 H40 beangbl67 CA897730 2614 321 83.1 blastp 1108 LYM137 H41 beetgbl62 BF011189 2615 321 82.5 blastp 2016213786 11 Aug 2016 1135 1134 1133 1132 1131 1130 1129 1128 1127 1126 1125 1124 1123 1122 1121 1120 1119 1118 1117 1116 1115 1114 1113 1112 - 1110 1109 Nucl. SEQ ID NO: LYM137 H67 LYM137 H66 LYM137 H65 LYM137 H64 LYM137 H63 LYM137 H230 LYM137 H229 LYM137 H228 LYM137 H227 LYM137 H226 LYM137 H58 LYM137 H57 LYM137 H56 LYM137 H55 LYM137 H54 LYM137 H53 LYM137 H52 LYM137 H51 LYM137 H50 LYM137 H49 LYM137 H48 LYM137 H47 LYM137 H46 LYM137 H45 LYM137 H225 LYM137 H224 LYM137 H42 Gene Name centaurea|gbl66|EH73 7696 centaurea|gbl 66|EH71 5158 O ft 3 o ζΛ on fJQ H-‘ CT K> it ON ON tn W ON L/i K> c atharanthus | gb 1661E G557604 c atharanthus | gb 1661E G556131 castorbean 09vl XMO 02531924 O P ζΛ o σ' ft 00 o 00 NO <3 Ή O •o o cassava 09vl DV4553 55 cassava 09vl CK6474 92 cassava|09v 1 |CK643 7 71 canola|gbl61|H07535 canola|gbl61|EE47936 8 canola|gb 161 |CN7310 28 canola|gb 161 |CN7260 29 canola|gb 161 |CD8216 63 canola|gbl61|CD8175 91 canola|gbl61|CD8169 02 canola|gbl61|CD8154 20 canola|gbl61|CD8125 01 canola|gbl61|CD8123 12 canola|gbl61|CD8122 85 canola|gbl61|CD8116 40 cacao gbl67CU47679 8 cacao gbl67CA79579 8 brachypodium 09vl D V489152 brachypodium 09vl D V476457 beetgbl62 BI096284 cluster name 2642 2641 2640 2639 2638 2637 2636 2635 2634 2633 2632 2631 2630 2629 2628 2627 2626 2625 2624 2623 2622 2621 2620 2619 2618 2617 2616 \ NO: Polyp. SEQ ID S' UJ UJ OJ UJ UJ OJ OJ UJ UJ OJ OJ UJ OJ OJ OJ OJ UJ OJ OJ OJ OJ UJ OJ OJ UJ OJ > § K> K> K> K> K> K> K> K> K> K> K> K> K> K> K> K> K> K> K> K> K> K> K> K> K> K) K) ^ 2* S.‘ Gro 00 NO 00 00 00 00 00 00 00 00 00 00 00 00 00 00 00 00 00 00 00 00 NO NO 00 4^ UJ 1° 1° 4^ 85 UJ OJ OJ UJ OJ OJ UJ UJ OJ ON ON 4^ OJ 4^ ON ON NO 00 bo bo bo K> bo bo K> K> K> K> K> K> bo bo 4^ σ' σ' σ' σ' σ' σ' σ' σ' σ' σ' σ' σ' σ' σ' σ' σ' σ' σ' σ' σ' σ' σ' σ' σ' σ' σ' σ' P P P P P P P P P P P P P P P P P P P P P P cr? ζΛ ζΛ ζΛ ζΛ ζΛ ζΛ ζΛ ζΛ ζΛ ζΛ ζΛ ζΛ ζΛ ζΛ ζΛ ζΛ ζΛ ζΛ ζΛ ζΛ ζΛ ζΛ ζΛ ζΛ ζΛ ζΛ ζΛ © >£f 7¾ 2016213786 11 Aug 2016 87 Nucl. SEQ ID NO: Gene Name cluster name Polyp. SEQ ID NO: Homolog. to SEQ ID NO: % global identity Algor. 1136 LYM137 H68 centaurea|gbl66|EH74 6709 2643 321 82.5 blastp 1137 LYM137 H231 chestout gb 170 SRRO0 6295S0004667 2644 321 83.8 blastp 1138 LYM137 H232 che stout gb 170 S RRO 0 6295S0010167 2645 321 83.1 blastp 1139 LYM137 H233 chickpea|09v2|FE6692 44 2646 321 85.6 blastp 1140 LYM137 H234 chickpea|09v2|FE6716 15 2647 321 85.6 blastp 1141 LYM137 H235 cichorium gbl71 DT2 10912 2648 321 84.3 blastp 1142 LYM137 H236 cichorium|gbl71 |EH6 81883 2649 321 84.4 blastp 1143 LYM137 H237 cichorium|gbl71 |EH6 96050 2650 321 83.8 blastp 1144 LYM137 H72 citrus|gbl66|CB61057 8 2651 321 83.7 blastp 1145 LYM137 H73 citrus|gbl66|CN18341 5 2652 321 82.9 blastp 1146 LYM137 H74 coffeagbl57.2 DV663 668 2653 321 85 blastp 1147 LYM137 H75 cotton gbl64AI72852 2 2654 321 84.3 blastp 1148 LYM137 H76 cotton gbl64AI72953 1 2655 321 85 blastp 1149 LYM137 H77 cotton|gbl64|BE05571 9 2656 321 83 blastp 1150 LYM137 H78 cotton|gbl64|BF26964 1 2657 321 84.3 blastp 1151 LYM137 H79 cotton|gb 164|BG4414 96 2658 321 81.8 blastp 1152 LYM137 H80 cowpea|gbl66|BE3362 50 2659 321 83.9 blastp 1153 LYM137 H81 cowpea gb 166 FF3 823 48 2660 321 85.1 blastp 1154 LYM137 H82 cowpea gbl 66 FF3912 67 2661 321 86.9 blastp 1155 LYM137 H83 cryptomeria|gb 1661 BP 176442 2662 321 80.5 blastp 1156 LYM137 H84 cryptomeri a| gb 16 61B W996322 2663 321 81.2 blastp 1157 LYM137 H238 cucumber 09v 1 BGI45 4H0165031 2664 321 81.6 blastp 1158 LYM137 H239 cucumber 09vl CKO 85 893 2665 321 83.7 blastp 1159 LYM137 H240 cucumber 09vl DV63 2825 2666 321 85 blastp 1160 LYM137 H85 cynara|gbl67|GE5881 38 2667 321 84.4 blastp 1161 LYM137 H86 dandelion gb 161 DY 8 04086 2668 321 85.1 blastp 1162 LYM137 H87 dandelion gb 161 DY 8 13115 2669 321 83.8 blastp 2016213786 11 Aug 2016 88 Nucl. SEQ ID NO: Gene Name cluster name Polyp. SEQ ID NO: Homolog. to SEQ ID NO: % global identity Algor. 1163 LYM137 H88 eucalyptus gbl 66 CT9 80143 2670 321 83.1 blastp 1164 LYM137 H89 eucalyptus gbl66 CT9 81000 2671 321 81.3 blastp 1165 LYM137 H90 fescue gbl61DT6864 72 2672 321 80.9 blastp 1166 LYM137 H241 flax|09vl|EU829592 2673 321 81 blastp 1167 LYM137 H242 gerbera 09vlAJ75070 7 2674 321 85.6 blastp 1168 LYM137 H243 gerbera 09v 11AJ75 312 7 2675 321 84.31 tblastn 1169 LYM137 H244 gerbera 09vl AJ75544 0 2676 321 81.7 blastp 1170 LYM137 H91 ginger|gbl64|DY3520 00 2677 321 85.5 blastp 1171 LYM137 H92 ginger|gbl64|DY3569 13 2678 321 83.7 blastp 1172 LYM137 H93 grape|gbl60|CA81633 5 2679 321 80.6 blastp 1173 LYM137 H94 grape|gbl60|CB34828 9 2680 321 81.3 blastp 1174 LYM137 H95 grape|gbl60|CB97964 1 2681 321 84.5 blastp 1175 LYM137 H96 iceplant|gbl64|CA834 927 2682 321 82.5 blastp 1176 LYM137 H97 ipomoe a gb 15 7.2 BU6 90174 2683 321 82.2 blastp 1177 LYM137 H98 ipomoea gbl 57.2 CJ73 8553 2684 321 82.9 blastp 1178 LYM137 H245 jatropha|09vl |G02473 33 2685 321 85.6 blastp 1179 LYM137 H99 kiwi|gbl66|FG413271 2686 321 83.1 blastp 1180 LYM137 H100 kiwi|gbl66|FG421995 2687 321 84.2 blastp 1181 LYM137 H101 kiwi|gbl66|FG429490 2688 321 83.9 blastp 1182 LYM137 H102 kiwi|gbl66|FG461535 2689 321 84.2 blastp 1183 LYM137 H103 kiwi gbl66FG501757 2690 321 83.6 blastp 1184 LYM137 H104 lettuce gbl57.2 CV700 088 2691 321 83.8 blastp 1185 LYM137 H105 lettuce gbl57.2 DW04 6053 2692 321 83 blastp 1186 LYM137 H106 lettuce gbl57.2 DW04 9273 2693 321 83.8 blastp 1187 LYM137 H107 lettuce gbl57.2 DW07 7894 2694 321 83.8 blastp 1188 LYM137 H108 lettuce gbl57.2 DW08 0256 2695 321 83.7 blastp 1189 LYM137 H109 lettuce gbl57.2 DW08 0360 2696 321 83.1 blastp 2016213786 11 Aug 2016 ft S © fi ιό ΙΌ ΙΌ ΙΌ ΙΌ ΙΌ ΙΌ ιό Κ) Κ) Κ) Κ) Κ) κ> κ> Κ) Κ) Ι-— I-— I-— I-— I-— I-— I-— ο ο ο ο ο ο ο ο ο ο ΝΟ NO NO NO NO NO NO NO NO NO to on LAl 40 LJ ιό ο NO 00 •ο ΟΝ L/i 40 LJ Κ) ο ΝΟ 00 •o ON LAI 40 LJ ΙΌ O r r r Γ r Γ r Γ Γ r Γ r r r r r r Γ r r r r r r r r r ε ^ ε ^ ε ^ ε ^ ε ^ Ε ^ Μ ^ Μ ^ Μ ^ Μ ^ Μ ^ Μ ^ Μ ^ Μ ^ Μ ^ Μ ^ Μ ^ Μ ^ E ^ E ^ E ^ E ^ E ^ E ^ E ^ E ^ E ^ ΟΝ ΓΤ LJ ΟΝ ΓΤ ω 2 ΟΝ ΓΤ 4° 2 ΟΝ ^ 1—1 LJ 2 2 °° 2 ΙΌ ξ ^ LO ΟΝ ΓΤ ° 2 to 2 <οι 2 ^ 2 <-η 2 °° ω κ> 2 L/i ^ ^ LO <-« 2 LO <-η 2 ^ ω κ> 2 L/i ^ OJ <-η 2 ω ω <-η 2 ^ ω κ> 2 L/i ^ 1—1 LO 2 S ω 2 S ^ 2 <-n 2 ° 2 2 ^ 2 2 °° 2 to s 40 ^ ^ LO 2 £ ω 2 to 2 4^ E LO 2 S 4° 2 2 g 1—1 LJ 2 £ ° 2 •ο •ο •ο •ο •ο •ο •ο •ο •ο •ο •ο •ο •ο •ο •ο •ο •ο •ο •o •o •o •o •Ό •Ό •Ό •Ό •Ό s a , , , | . _ | . | . 3 3 3 3 3 a 3 3 a 3 3 3 b 3 a 3 ν' ft CTQ σ' ο Ο o o O O iquorice gbl71 FS2 986 ft ft ο & 0¾ Ό Ε5 ο & to CS αΓ <? "ο § £ ft" "ο NO <ί 2- ο 3 CTQ σ' 3- ο 3 CTQ σ' edicago 09vl LL^ 46422 ft & ο" ρ> CTQ •Ό Ο a & ο" CTQ οο Ο 3 Ν* a CTQ σ' 3 ν' a CTQ υ, ε 3 ν' ct CTQ Lh Ζ 3 ν' ft CTQ ο ζ ρ ν' ft CTQ σ' ν' ft CTQ σ' <ί ft CTQ ι-i Ρ3 ζΛ LAI <ί ft CTQ ι-t Ρ3 CA) LO 2 CA) O NO £ CA! O NO 2 CA! O NO o NO ο" Co ft a I CA! CTQ σ' £ o ft CTQ lai σ' £ o ft CTQ ιό σ' cluster name 4ο Ο 00 < £ S ON i-j 00^ NO <ί II ° ο NO <ί Ο NO ~Μ NO << 40 LAI η ο •ο ΙΌ L/I •ο « S ο <J ΟΝ LJ L65|DV63: 25 NO Ο •ο 80 L/i <ί ^ Ο LJ 80 NO < •ο ο Η 00 •ο ^ r r ο ο r r ο ο S, -ο r r ω ο ^ £ tn ΝΟ ΟΝ κ> 80 -ο ο > ΟΝ Κ) «ο ο •ο ΝΟ NO CTQ on σ' •ο Η-ON •ο tn κ LAi CTQ •ο σ' 40 H- ON •o tn X ^ r r o o O O r ω E 00 00 -=H LAI r tn o ON ON to 2 δ ΙΌ LAI LJ P LO _^_ on rjq •Ό σ* ON ON O Ο H- NO ON ON n a 00 o Ό ^ 00 '-J ΙΌ a ΙΌ ^ NO LJ 'O (Ό a "S •<1 ΙΌ ro ΙΌ Κ) Κ) Κ> Κ> LO ο ON ON K) O LJ NO Ο id 00 NO 00 00 00 ο 4^ 40 Κ) κ> 40 κ> 00 00 NO 00 K> 1—1 K NO ΙΌ 40 1—1 ΙΌ ιό ΙΌ ΙΌ ΙΌ ΙΌ ιό ΙΌ κ> Κ) Κ) Κ) Κ) Κ) Κ> Κ) Κ) K) K> K) K) ΙΌ ΙΌ ΙΌ ΙΌ ΙΌ ΙΌ ^-15 •ο •ο •ο •ο •ο •ο •ο •ο •ο •ο •ο •Ο •ο •ο •ο •ο •ο •o •o •o •o •Ό •Ό •Ό ON ON ON ΙΌ ιό ΙΌ ιό Ο ο ο o o o o O O O NO NO NO OJ ιό ο NO 00 •ο ΟΝ L/i 4^ LJ Κ) ο ΝΟ 00 •ο ON LAi 40 LJ ΙΌ o NO 00 •Ό - δ^3 2 E OJ UJ LJ LJ LJ LJ LJ LJ LJ LJ LJ LJ LJ LJ LO LO LJ LJ LJ LJ LJ LJ LJ LJ LJ LJ LJ omol SEQ NO: ιό ΙΌ ΙΌ ΙΌ ΙΌ ΙΌ ΙΌ Κ) Κ> Κ) Κ) Κ) Κ) Κ) Κ) Κ) Κ) K) K) K) K) ΙΌ ΙΌ ΙΌ ΙΌ ΙΌ ΙΌ 00 00 NO NO 00 00 L/I 82.47 00 00 NO 00 NO NO 82.89 ΝΟ ΝΟ ΝΟ NO 00 00 00 LAi NO 00 00 NO 00 00 s: »q U) U) 40 4ο Ό LJ Ό LJ ΟΝ Ν/ι LJ 4^ Ιο NO OJ 40 40 LJ 40 ρ 1° bo LJ LJ NO •Ό *40 LAi LJ LJ NO 0C Ό LJ bo LJ *00 11 ^ σ' σ' σ' σ' σ' σ' σ1 σ' σ' σ' σ' σ' σ' σ1 σ' σ' σ' σ' σ' σ' σ' σ' σ' σ' σ' σ' σ' Ρ Ρ Ρ Ρ Ρ Ρ £! £! £! £! £! cr? CA! CA! CA! CA! CA! CA! CA! ζΛ ζΛ ζΛ ζΛ ζΛ ζΛ ζΛ ζΛ ζΛ CA! ζΛ CA! CA! CA! CA! CA! CA! CA! CA! CA! © >£ 2 >8 2016213786 11 Aug 2016 90 Nucl. SEQ ID NO: Gene Name cluster name Polyp. SEQ ID NO: Homolog. to SEQ ID NO: % global identity Algor. 1217 LYM137 H129 nicotiana benthamiana| gb 1621E S 885186 2724 321 85.7 blastp 1218 LYM137 H130 nuphar|gb 166|FD3 861 60 2725 321 85.8 blastp 1219 LYM137 H265 oakgbl70 CU656727 2726 321 83.1 blastp 1220 LYM137 H266 oak gbl70 SRR006307 S0003551 2727 321 83.8 blastp 1221 LYM137 H131 oat|gbl64|CN814837 2728 321 98 blastp 1222 LYM137 H132 oil palm|gbl66|CN59945 7 2729 321 87.2 blastp 1223 LYM137 H133 oil palm|gbl66|EL688664 2730 321 84.5 blastp 1224 LYM137 H134 onion gbl 62 CF45144 2 2731 321 85.2 blastp 1225 LYM137 H135 papaya|gbl65|EX2389 83 2732 321 83.1 blastp 1226 LYM137 H136 papaya|gbl65|EX2817 27 2733 321 84.3 blastp 1227 LYM137 H267 peanut gb 171 CD03 80 36 2734 321 84.4 blastp 1228 LYM137 H268 peanut gb 171 CD03 80 42 2735 321 83.2 blastp 1229 LYM137 H269 peanut gb 171 EH0429 12 2736 321 85.1 blastp 1230 LYM137 H270 pea|09vl|EX570565 2737 321 83.7 blastp 1231 LYM137 H271 pepper gbl71 BM0631 92 2738 321 83 blastp 1232 LYM137 H272 pepper gb 171 CA5184 36 2739 321 81.8 blastp 1233 LYM137 H273 petunia gb 171 CV2988 26 2740 321 83 blastp 1234 LYM137 H274 petunia gbl 71CV2990 96 2741 321 83.7 blastp 1235 LYM137 H275 petunia|gbl71|FN0076 57 2742 321 83.1 blastp 1236 LYM137 H276 poplar|gb 1701AI16182 2 2743 321 81.8 blastp 1237 LYM137 H277 poplar|gb 1701 AI16481 2 2744 321 80.4 blastp 1238 LYM137 H278 poplar|gbl70|CN5176 15 2745 321 81.58 tblastn 1239 LYM137 H150 poppy gbl66 FE96448 2 2746 321 82.6 blastp 1240 LYM137 H151 poppy gbl66 FE96848 9 2747 321 83.9 blastp 1241 LYM137 H152 potato|gbl57.2|BE923 747 2748 321 83.7 blastp 1242 LYM137 H153 potato|gbl57.2|BF459 639 2749 321 83.7 blastp 2016213786 11 Aug 2016 ft S © fi ιό ΙΌ ΙΌ ΙΌ ΙΌ ΙΌ ΙΌ ΙΌ ΙΌ ΙΌ ΙΌ ΙΌ ΙΌ ΙΌ ΙΌ ΙΌ ΙΌ ΙΌ ΙΌ ΙΌ ΙΌ ΙΌ ΙΌ ΙΌ ΙΌ ΙΌ os Os Os Os Os Os Os Os Os LAi LAI LAI LAi LAI LAI LAI LAi LAi LAi 4L 4L 4L 4L 4L 4L 4L to 00 •Ό Os LAI 4^ LJ ΙΌ O SO 00 •Ό Os LAI 4L LJ ΙΌ O SO 00 •ο Os LAi 4L LJ r r r r r r r r r r r r r r r r r r r r r r r r r r a ^ a ^ a ^ a ^ a ^ a ^ a ^ a ^ a ^ a ^ a ^ a ^ a ^ a ^ a ^ a ^ a ^ a ^ a ^ a ^ a ^ a ^ a ^ a ^ a ^ a ^ 00 2 1—1 UJ ^ ω °° ω ^g ^ LO ^g ^ LO 00 ^ ° w ό tn ^ ω ^g ω ω ^g ω ^g 1—1 LJ ° ω σ\ p 'Ό ω σ\ p °° ω Os ^ ^ LO σ\ ρ LO σ\ ρ ^ ω σ\ ρ LJ σ\ p ω ω σ\ p σ\ p 1—1 LJ σ\ p ° ω <7i p <7i p °° ω la! 2 ^ LO <7i p LO <7i ρ ^ ω •ο •Ό •Ό •Ό •Ό •Ό •Ό •Ό •Ό •Ό •Ό •Ό •Ό •Ό •ο •ο •ο •ο •Ό •Ό •Ό •Ό •Ό •Ό •Ό •Ό CA! a σ a CA! P 3 CA! P 3 CA! P 3 >3 a o' o o' O ι-t g O- i-t g CL i-t g CL i-t σ & ι-t σ & ι-t σ & 1-t σ & i-t g CL i-t g CL 1-t g CL ι-t g CL i-t g CL i-t g CL i-i g CL n? CA! ft nj nj n? o S n? o S ο o' o ο ί o CTQ σ' CTQ σ' CTQ σ' σ' CTQ σ' CTQ σ' CTQ _σ^ _σ^ _σ^ _σ^ σ' CTQ σ' CTQ σ' CTQ σ' CTQ σ' CTQ σ' CTQ σ' CTQ ^ R' σ CA! σ CA! _o_ o CTQ Ci S CTQ 4l σ' OJ H- so -ο o er gbl6 1711 er gbl6 9454 er gbl6 8228 os 4^ tn tn •Ό -J ® ο o 00 •Ό Ο o 00 σ' [x Os ^ 4L tn σ' [x Os ^ 4L tn σ' os 4L tn σ' ^ Os 00 j2 "tn σ^ Ο JL tn σ' 05 •Ό 4^ tn σ^ ^ Os LAi _ρ^ "tn σ' μ ξ Μ σ' 00 g Μ σ' ^ 2 Μ σ' w σ' CTn g W σ' W σ' W fo n gbl67 BU5 74 gbl67 BUO 09 σ' os H- LAi LAi 00 Ό (Ό ;bl57.2 78 5¾ >8 S Si o ΙΌ tn ΙΌ tn ΙΌ tn SO LJ SO 00 •Ό 4^ o δ X •Ό LAi X •o LAi X •o LAI •Ό •Ό •ο •Ό <J LAI Ό <J LAI 4L <J LAi LJ <J LAi LJ <J LAi ΙΌ <J LAi ΙΌ <J LAi ΙΌ •Ό i_I σ CTQ a o Cd E I Os t-1 t-1 t-1 4^ ΙΌ Ό Os LAi LJ LJ ΙΌ ΙΌ Ο LAI SO Os Ό Os 4L σ' •Ό 4L O o Os 4L LJ LJ ΙΌ 4^ 00 •Ό Os ΙΌ Η-» 4L 4L 4L ΙΌ Ο SO 00 •Ό 4L ΙΌ 00 4L •Ό Os SO •Ό ΙΌ Os ΙΌ 00 4L •Ό SO •Ό 4L SO 4L 00 4L o LJ Os o Os O ΙΌ ΙΌ ΙΌ ΙΌ ΙΌ ΙΌ ΙΌ ΙΌ ΙΌ ΙΌ ΙΌ ΙΌ ΙΌ ΙΌ ΙΌ ΙΌ ΙΌ ΙΌ ΙΌ ΙΌ ΙΌ ΙΌ ΙΌ ΙΌ ΙΌ ΙΌ •o •Ό •Ό •Ό •Ό •Ό •Ό •Ό •Ό •Ό •Ό •Ό •ο •ο •ο •ο •ο •Ό •Ό •Ό •Ό •Ό •Ό •Ό •Ό •Ό •o •Ό •Ό •Ό •Ό •Ό Os Os Os Os Os OS OS OS OS Os LAi LAi LAi LAi LAi LAi LAi LAi LAI LAI LAi -|L LJ ΙΌ O SO 00 •Ό Os LAI 4L LJ ΙΌ Ο SO 00 •Ό Os LAi 4L LJ ΙΌ O - s· a LJ LJ LJ LJ LJ LJ LJ LJ LJ LJ LJ LJ LJ LJ LJ LJ LJ LJ LJ LJ LJ LJ LJ LJ LJ LJ omol SEQ NO: ΙΌ ΙΌ ΙΌ ΙΌ ΙΌ ΙΌ ΙΌ ΙΌ ΙΌ ΙΌ ΙΌ ΙΌ ΙΌ ΙΌ ΙΌ ΙΌ ΙΌ ΙΌ ΙΌ ΙΌ ΙΌ ΙΌ ΙΌ ΙΌ ΙΌ ΙΌ 00 LJ 00 00 00 SO SO 00 00 00 00 00 00 00 00 00 00 00 00 00 00 SO 00 00 00 00 B; &q a- LJ ΙΌ o 4^ ΙΌ LJ o Η— LJ Η— Η— Η— LJ ΙΌ 00 LJ LJ ΙΌ ΙΌ a 2. ^ © Ό bo 4L o (Ό ΙΌ bo *4L ΙΌ ΙΌ Η- ΙΌ ΙΌ ΙΌ ΙΌ ΙΌ ΙΌ LAi Ό bo bo LAI LAi ». a S' σ1 σ' σ' σ' σ' σ' σ' σ' σ' σ' σ' σ' σ' σ' σ' σ' σ' σ' σ' σ' σ' σ' σ' σ' σ' σ' P P P P P P σ σ σ σ σ σ σ σ σ σ σ σ σ σ σ σ σ σ σ cr? CA! CA! CA! CA! CA! CA! CA! CA! CA! CA! CA! CA! CA! CA! CA! CA! CA! CA! CA! CA! CA! CA! CA! CA! CA! CA! a >8 2016213786 11 Aug 2016 92 Nucl. SEQ ID NO: Gene Name cluster name Polyp. SEQ ID NO: Homolog. to SEQ ID NO: % global identity Algor. 1269 LYM137 H282 solanum phurej a| 09v 11SPHAA8 24956 2776 321 82.5 blastp 1270 LYM137 H283 solanum phurej a| 09v 11SPHBQ1 15070 2777 321 82.69 tblastn 1271 LYM137 H284 solanum phurej a|09vl|SPHTO M289A 2778 321 83.7 blastp 1272 LYM137 H285 sorghum 09v 1 SB06G 021660 2779 321 94.7 blastp 1273 LYM137 H286 sorghum 09v 1 SB 10G 005240 2780 321 94.1 blastp 1274 LYM137 H182 soybean|gbl68|AL365 737 2781 321 85.6 blastp 1275 LYM137 H183 soybean gbl 68 AW20 8139 2782 321 84.3 blastp 1276 LYM137 H184 soybean gbl68 AW28 7975 2783 321 85.6 blastp mi LYM137 H185 soybean|gbl68|BE336 250 2784 321 81.9 blastp 1278 LYM137 H186 soybean|gbl68|BE336 251 2785 321 84.5 blastp 1279 LYM137 H187 soybean gbl68 BI9675 38 2786 321 85 blastp 1280 LYM137 H188 spurge gbl61 BI99357 4 2787 321 83.8 blastp 1281 LYM137 H189 strawberry gb 164 C03 78565 2788 321 83.7 blastp 1282 LYM137 H190 strawberry|gbl 64|EX6 85316 2789 321 82.5 blastp 1283 LYM137 H287 sugarcane gbl57.3 AI2 16927 2790 321 94.7 blastp 1284 LYM137 H288 sugarcane gbl57.3 BQ 535570 2791 321 92.8 blastp 1285 LYM137 H289 sugarcane gbl57.3 BQ 535956 2792 321 94.1 blastp 1286 LYM137 H290 sugarcane gbl57.3 BQ 537453 2793 321 93.4 blastp 1287 LYM137 H291 sugarcane gbl57.3 CA 106878 2794 321 94.7 blastp 1288 LYM137 H292 sugarcane gbl57.3 CA 111839 2795 321 93.4 blastp 1289 LYM137 H293 sugarcane gbl57.3 CA 113465 2796 321 92.11 tblastn 1290 LYM137 H198 sunflower gb 162 CD8 46067 2797 321 84.3 blastp 1291 LYM137 H199 sunflower gb 162 CD8 48213 2798 321 84.3 blastp 1292 LYM137 H200 sunflower gb 162 CD8 51130 2799 321 85.6 blastp 1293 LYM137 H201 sunflower gb 162 CD8 53875 2800 321 83.8 blastp 2016213786 11 Aug 2016 93 Nucl. SEQ ID NO: Gene Name cluster name Polyp. SEQ ID NO: Homolog. to SEQ ID NO: % global identity Algor. 1294 LYM137 H202 switchgras s gb 167 DN 140751 2801 321 92.8 blastp 1295 LYM137 H203 switchgrass gb167 DN 143966 2802 321 90.8 blastp 1296 LYM137 H204 switchgrass gb 167 FE6 03312 2803 321 91.4 blastp 1297 LYM137 H205 switchgrass gb 167 FE6 45253 2804 321 92.8 blastp 1298 LYM137 H294 teagbl71 GE652357 2805 321 84.52 tblastn 1299 LYM137 H295 tea gb 171 GH613259 2806 321 81.2 blastp 1300 LYM137 H206 thellungiella gb 167 D N773656 2807 321 81.2 blastp 1301 LYM137 H207 tobacco gb 162 DV157 653 2808 321 82.5 blastp 1302 LYM137 H208 tobacco|gbl62|EB444 171 2809 321 85.1 blastp 1303 LYM137 H209 tobacco|gbl62|EB445 443 2810 321 85.6 blastp 1304 LYM137 H210 tobacco gbl62 EB679 214 2811 321 83.8 blastp 1305 LYM137 H211 tobacco|gbl62|TOBRP L25A 2812 321 85.7 blastp 1306 LYM137 H296 tomato 09v 1 AA82495 6 2813 321 81.8 blastp 1307 LYM137 H297 tomato |09vl |BQ11507 0 2814 321 83.8 blastp 1308 LYM137 H298 tomato 09vl TOM289 A 2815 321 83.7 blastp 1309 LYM137 H214 wheat|gbl64|BE40186 0 2816 321 99.3 blastp 1310 LYM137 H215 wheat|gbl64|BE40351 6 2817 321 99.3 blastp 1311 LYM137 H216 wheat|gbl64|BE40448 8 2818 321 99.3 blastp 1312 LYM137 H217 wheat|gbl64|CA61289 8 2819 321 82.89 tblastn 1313 LYM137 H299 zinnia| gb 1711AU3 044 73 2820 321 83 blastp 1314 LYM140 H18 apple gbl71 CN87400 7 2821 322 80.1 blastp 1315 LYM140 HI banana|gbl67|ES4337 90 2822 322 80 tblastn 1316 LYM140 H19 brachypodium 09vl D V472528 2823 322 90.3 blastp 1317 LYM140 H20 cassava 09vl BM2597 38 2824 322 80.3 blastp 1318 LYM140 H21 cassava 09vl CK6408 86 2825 322 80.3 blastp 1319 LYM140 H22 castorbean|09vl |EG65 6528 2826 322 80.4 blastp 1320 LYM140 H23 chestnut gbl70 SRR00 6295S0060343 2827 322 80 blastp 2016213786 11 Aug 2016 94 Nucl. SEQ ID NO: Gene Name cluster name Polyp. SEQ ID NO: Homolog. to SEQ ID NO: % global identity Algor. 1321 LYM140 H24 chestout gb 170 SRRO0 6296S0039724 2828 322 80.49 tblastn 1322 LYM140 H4 citrus|gbl66|CB29047 9 2829 322 80.3 blastp 1323 LYM140 H5 cotton gb 164 BF27194 2 2830 322 81.4 blastp 1324 LYM140 H6 cotton gb 164 CA9926 95 2831 322 80.1 blastp 1325 LYM140 H7 cowpeagbl66 FC4597 91 2832 322 80.48 tblastn 1326 LYM140 H25 maize|gbl70|AW3312 87 2833 322 89.2 blastp 1327 LYM140 H9 oil palm|gbl66|ES414711 2834 322 80.8 blastp 1328 LYM140 H10 papaya gbl 65 EX2277 99 2835 322 80 blastp 1329 LYM140 HI 1 radish|gbl64|EV52827 2 2836 322 80.3 blastp 1330 LYM140 H26 rice gbl70 OS04G532 10 2837 322 88.6 blastp 1331 LYM140 H27 sorghum 09v 1 SB06G 028990 2838 322 88.9 blastp 1332 LYM140 H13 soybean gb 168 AW 12 6193 2839 322 80 blastp 1333 LYM140 H28 sugarcane gbl57.3 CA 071893 2840 322 88.1 blastp 1334 LYM140 H15 sunflower gb 162 BU6 71805 2841 322 80.1 blastp 1335 LYM140 H16 switchgrass gbl 67 FE6 24047 2842 322 90.5 blastp 1336 LYM140 H17 wheat|gbl64|BE41572 6 2843 322 98.1 blastp 1337 LYM140 H18 wheat|gbl64|BF20061 3 2844 322 86.7 blastp 1338 LYM141 HO rice gbl70 OS12G029 10 2845 323 86.6 blastp 1339 LYM142 H7 barley gb 157 SOLEXA IBQ761869 2846 324 86.6 blastp 1340 LYM142 H8 brachypodium 09vl D V478753 2847 324 86.8 blastp 1341 LYM142 H3 leymus gb 166 EG4015 96 2848 324 97.7 blastp 1342 LYM142 H4 pseudoroegneria gb 16 7IFF362922 2849 324 97.7 blastp 1343 LYM142 H9 rice gbl70 OS02G335 50 2850 324 83.9 blastp 1344 LYM142 H6 wheat|gbl64|BE40484 3 2851 324 94.4 blastp 1345 LYM142 H7 wheat|gbl64|CA63146 7 2852 324 83.9 blastp 1346 LYM144 HO brachypodium 09vl G T775853 2853 326 80.6 blastp 1347 LYM148 H10 brachypodium 09vl D V478384 2854 328 91.1 blastp 2016213786 11 Aug 2016 95 Nucl. SEQ ID NO: Gene Name cluster name Polyp. SEQ ID NO: Homolog. to SEQ ID NO: % global identity Algor. 1348 LYM148 H2 leymus gb 16 6 EG3 9 89 61 2855 328 92.73 tblastn 1349 LYM148 HI 1 maize|gbl70|AW0600 86 2856 328 84.5 blastp 1350 LYM148 H12 millet 09vlEVO454P M023692 2857 328 82.9 blastp 1351 LYM148 H13 rice gb 170 OS06G454 40 2858 328 82.4 blastp 1352 LYM148 H14 sorghum 09v 1 SB 10G 026570 2859 328 83.3 blastp 1353 LYM148 H6 switchgrass gbl67 FE6 04043 2860 328 82.5 blastp 1354 LYM148 H7 switchgrass gb 167 FE6 41627 2861 328 81.1 blastp 1355 LYM148 H8 wheat|gbl64|BE44289 6 2862 328 96.3 blastp 1356 LYM148 H9 wheat|gbl64|BQ29525 9 2863 328 97 blastp 1357 LYM148 H10 wheat|gbl64|BQ78864 1 2864 328 97 blastp 1358 LYM149 H5 brachypodium 09vl D V488199 2865 329 83.2 blastp 1359 LYM149 H2 pseudoroegneria gb 16 7IFF346387 2866 329 87 blastp 1360 LYM149 H3 wheat|gbl64|BE42905 2 2867 329 87.2 blastp 1361 LYM149 H4 wheat|gb 164|BQ62013 8 2868 329 87.5 blastp 1362 LYM149 H5 wheat|gbl64|CA64142 4 2869 329 89.69 tblastn 1363 LYM152 H14 arabidopsis lyrata|09vl IBQ834051 2870 330 86.7 blastp 1364 LYM152 H15 arabidopsis lyrata|09vl |JGIAL030 307 2871 330 96.7 blastp 1365 LYM152 HI arabidopsis gb 165 AT 4G25890 2872 330 82.5 tblastn 1366 LYM152 H2 b oleracea|gb 161 |DY 027 305 2873 330 95 blastp 1367 LYM152 H3 b oleracea gb 161 DY028 937 2874 330 93.4 blastp 1368 LYM152 H4 b rapa|gbl62|BG544013 2875 330 94.17 tblastn 1369 LYM152 H5 b rapa|gbl62|L35776 2876 330 92.6 blastp 1370 LYM152 H6 b rapa|gbl62|L35823 2877 330 95 blastp 1371 LYM152 H7 canola|gbl61|CD8120 96 2878 330 94.2 blastp 1372 LYM152 H8 canola|gbl61|CD8125 52 2879 330 95 blastp 2016213786 11 Aug 2016 96 Nucl. SEQ ID NO: Gene Name cluster name Polyp. SEQ ID NO: Homolog. to SEQ ID NO: % global identity Algor. 1373 LYM152 H9 canolagbl61 CD8170 37 2880 330 95 blastp 1374 LYM152 H10 canola|gbl61|CD8303 47 2881 330 92.6 blastp 1375 LYM152 H12 radish|gbl64|EV54823 5 2882 330 92.5 blastp 1376 LYM152 H13 radish| gb 164 |E W 7181 96 2883 330 92.5 blastp 1377 LYM152 H14 thellungiella gb167 B M985697 2884 330 91.7 blastp 1378 LYM153 H6 barley gb 157 SOLEXA IBF625242 2885 331 81.5 blastp 1379 LYM153 H7 brachypodium 09v 1 S RR031796S0027091 2886 331 81.5 blastp 1380 LYM153 H2 cenchrus|gbl66|EB654 758 2887 331 80 blastp 1381 LYM153 H8 millet 09vlEVO454P M017552 2888 331 83.1 blastp 1382 LYM153 H9 sorghum 09v 1 SB 10G 003440 2889 331 81.5 blastp 1383 LYM153 H4 switchgrass gbl 67 FE6 34744 2890 331 83.1 blastp 1384 LYM153 H5 wheat gbl 64 CD49095 1 2891 331 94.03 tblastn 1385 LYM153 H6 wheat|gbl64|CK21566 0 2892 331 80.3 tblastn 1386 LYM156 H6 barley gb 157 SOLEXA IAL506124 2893 332 96.1 blastp 1387 LYM156 H7 barley gb 157 SOLEXA IBE195142 2894 332 93.1 blastp 1388 LYM156 H3 pseudoroegneria gb 16 7IFF346665 2895 332 92.8 blastp 1389 LYM156 H4 pseudoroegneria gb 16 7IFF354463 2896 332 86.3 blastp 1390 LYM156 H8 rice gbl70 OS07G468 30 2897 332 80 blastp 1391 LYM156 H6 wheat|gbl64|BE63788 8 2898 332 91.8 blastp 1392 LYM157 HI barley gb 157 SOLEXA IBG299283 2899 333 94.9 blastp 1393 LYM159 HI wheat|gbl64|CA59814 8 2900 334 81.01 tblastn 1394 LYM159 H2 wheat|gbl64|CD86603 7 2901 334 87.7 blastp 1395 LYM159 H3 wheat|gbl64|CD86735 6 2902 334 86.4 blastp 1396 LYM160 HI wheat gbl 64 BE39999 7 2903 335 87.6 tblastn 1397 LYM160 H2 wheat|gbl64|BE50020 0 2904 335 80 blastp 1398 LYM161 HO brachypodium 09vl D V471902 2905 336 81.9 blastp 1398 LYM161 HO brachypodium 09vl D V471902 2905 444 81.02 tblastn 2016213786 11 Aug 2016 97 Nucl. SEQ ID NO: Gene Name cluster name Polyp. SEQ ID NO: Homolog. to SEQ ID NO: % global identity Algor. 1399 LYM162 H5 maize|gbl70|AW3311 05 2906 337 84.8 blastp 1400 LYM162 H6 millet 09vlEVO454P M026751 2907 337 85.7 blastp 1401 LYM162 H7 sorghum 09vl SB03G 043995 2908 337 87.5 blastp 1402 LYM162 H8 sugarcane gbl57.3 BQ 536349 2909 337 87.5 blastp 1403 LYM162 H4 switchgrass gb 167 FL7 38992 2910 337 83.9 blastp 1404 LYM162 H5 switchgrass gb 167 FL8 29126 2911 337 85.7 blastp 1405 LYM165 H5 maize | gb 17 01LLC04 5 2769 2912 339 99.2 blastp 1406 LYM165 H6 sorghum 09vl SB03G 030690 2913 339 89.2 blastp 1407 LYM165 H7 sugarcane gbl57.3 BQ 529806 2914 339 81.1 blastp 1408 LYM165 H8 sugarcane gbl57.3 CA 084294 2915 339 90.4 blastp 1409 LYM165 H4 switchgrass gb 167 DN 143471 2916 339 85.9 blastp 1410 LYM165 H5 switchgrass gb 167 DN 144101 2917 339 85.7 blastp 1411 LYM166 HI brachypodium 09vl D V486893 2918 340 85.4 tblastn 1411 LYM166 HI brachypodium 09vl D V486893 2918 445 85.36 tblastn 1412 LYM170 H7 barley gb 157 SOLEXA |AV915706 2919 341 91.6 blastp 1413 LYM170 H8 brachypodium 09v 1 S RR031797S0049196 2920 341 94.8 blastp 1414 LYM170 H9 maize|gbl70|AI66590 2 2921 341 87.3 blastp 1415 LYM170 H10 maize|gbl70|BE05062 8 2922 341 86.4 blastp 1416 LYM170 HI 1 sorghum 09v 1 SB03G 036440 2923 341 87.3 blastp 1417 LYM170 H12 sugarcane gbl57.3 CA 067017 2924 341 88.3 blastp 1418 LYM170 H6 switchgrass gb 167 DN 142710 2925 341 87.3 blastp 1419 LYM170 H7 wheat|gbl64|BE41537 1 2926 341 93.5 blastp 1420 LYM172 HI 1 brachypodium 09vl D V489358 2927 342 87.6 blastp 1421 LYM172 H12 maize gbl70 AA97977 0 2928 342 81.7 blastp 1422 LYM172 H13 maize|gbl70|AI71196 6 2929 342 81.2 blastp 1423 LYM172 H14 maize|gbl70|AI94752 1 2930 342 80.71 tblastn 1424 LYM172 H15 maize|gbl70|AW1201 45 2931 342 82.9 blastp 2016213786 11 Aug 2016 98 Nucl. SEQ ID NO: Gene Name cluster name Polyp. SEQ ID NO: Homolog. to SEQ ID NO: % global identity Algor. 1425 LYM172 H16 millet 09vlEVO454P M002481 2932 342 85.6 tblastn 1426 LYM172 H17 rice gbl70 OS02G083 64 2933 342 81.8 blastp 1427 LYM172 H18 sorghum 09v 1 SB04G 005430 2934 342 80.43 tblastn 1428 LYM172 H19 sorghum 09v 1 SB 10G 025800 2935 342 83.9 blastp 1429 LYM172 H20 sugarcane gbl57.3 CA 071007 2936 342 80.1 blastp 1430 LYM172 H9 switchgrass gbl 67 FL6 92588 2937 342 80.7 blastp 1431 LYM172 H10 wheat|gbl64|BE40076 1 2938 342 81.25 tblastn 1432 LYM172 HI 1 wheat gbl 64 BE49886 8 2939 342 87.77 tblastn 1433 LYM213 HI switchgrass gb 167 FE6 20008 2940 343 80.4 blastp 1433 LYM213 HI switchgrass gbl67 FE6 20008 2940 386 88.7 blastp 1434 LYM174 H3 maize | gb 1701 AW 1449 17 2941 344 89.4 blastp 1435 LYM174 H4 maize|gbl70|AW2673 79 2942 344 86.6 blastp 1436 LYM174 H5 sugarcane gbl57.3 CA 089309 2943 344 92.31 tblastn 1437 LYM174 H3 switchgrass gb167 DN 150662 2944 344 80.9 blastp 1438 LYM175 HO maize|gbl70|AW4984 64 2945 345 81.2 blastp 1439 LYM175 HI rice gbl70 OS01G690 90 2946 345 95 blastp 1439 LYM175 HI rice gbl70 OS01G690 90 2946 446 100 blastp 1440 LYM215 H2 sorghum|09v 1 |SB03G 043980 2947 345 81.2 blastp 1440 LYM215 H2 sorghum|09v 1 |SB03G 043980 2947 387 94.6 blastp 1441 LYM176 H2 maize|gbl70|CA45271 3 2948 346 82.2 blastp 1442 LYM176 H3 sorghum|09v 1 |SB03G 036470 2949 346 83 blastp 1443 LYM176 H2 switchgrass gbl67 FE6 06366 2950 346 82 blastp 1444 LYM178 H9 brachypodium 09vl D V472161 2951 347 84.9 blastp 1445 LYM178 H10 brachypodium 09v 1 S RR031797S0177787 2952 347 84.6 blastp 1446 LYM178 HI fescue gbl61DT6744 27 2953 347 89.4 blastp 1447 LYM178 H2 leymus gb 16 6 EG3945 91 2954 347 84.08 tblastn 1448 LYM178 HI 1 maize|gbl70|W21746 2955 347 83.4 blastp 2016213786 11 Aug 2016 1470 1470 1469 1468 1467 1466 1465 1465 1464 1464 1463 1463 1462 1462 1461 1460 1459 1458 1457 1456 1455 1454 1453 1452 1451 1450 1449 Nucl. SEQ ID NO: LYM117 H2 LYM117 H2 LYM116 H3 LYM116 H2 LYM116 H3 LYM115 HO LYM112 H2 LYM112 H2 LYM112 HI LYM112 HI LYM109 H2 LYM109 H2 LYM109 HI LYM109 HI LYM107 H5 LYM107 H4 LYM107 H3 LYM107 H2 LYM179 HO LYM178 H9 LYM178 H8 LYM178 H16 LYM178 H15 LYM178 H14 LYM178 H13 LYM178 H3 LYM178 H12 Gene Name maize 1 gb 17 01GFXAF 2 43041X1 maize | gb 17 01 GFXAF 2 43041X1 switchgrass gbl67 FL7 90906 switchgrass gb 167 FE6 53493 sorghum 09v 1 SB06G 031340 sorghum 09v 1 SBO1G 043900 sorghum|09vl|SB02G 039985 sorghum|09vl|SB02G 039985 maize|gbl70|CF03732 2 maize|gbl70|CF03732 2 sorghum 09vl SB05G 003660 sorghum 09vl SB05G 003660 maize|gbl70|BG51716 3 maize|gbl70|BG51716 3 sorghum|09v 1 |SB03G 036480 rice gb 170 OS05G266 60 maize|gbl70|CF07558 7 brachypodium 09vl G T808738 sorghum|09v 1 |SB08G 006470 wheat|gbl64|BQ62075 2 switchgrass gb 167 FE6 36508 sugarcane gbl57.3 CA 079726 691990 sorghum 09v 1 SB07G 001060 sorghum| 09v 11SB03G 008890 pseudoroegneria gb 16 7IFF358503 millet 09vlEVO454P M001531 cluster name 2977 2977 2976 2975 2974 2973 2972 2972 2971 2971 2970 2970 2969 2969 2968 2967 2966 2965 2964 2963 2962 2961 2960 2959 2958 2957 2956 Polyp. SEQ ID NO: 449 355 354 354 354 353 448 351 448 351 447 350 447 350 349 349 349 349 348 347 347 347 347 347 347 347 347 Homolog. to SEQ ID NO: 84.5 84.4 00 © 00 00 00 © 00 00 88.2 6Γ06 84.8 92.43 93.96 95.4 88.87 88.75 82.6 82.62 95 86.4 95.2 OO σ\ so 86.5 94.7 82.4 OO 82.4 81.9 OO 93.6 OO % global identity blastp blastp tblastn tblastn blastp tblastn blastp tblastn tblastn blastp tblastn tblastn tblastn tblastn blastp blastp blastp blastp blastp blastp blastp blastp blastp blastp blastp blastp blastp Algor. 2016213786 11 Aug 2016 100 Nucl. SEQ ID NO: Gene Name cluster name Polyp. SEQ ID NO: Homolog. to SEQ ID NO: % global identity Algor. 1471 LYM117 H3 sorghum 09vlSB07G 027220 2978 355 82.3 blastp 1471 LYM117 H3 sorghum 09vlSB07G 027220 2978 449 82.3 blastp 1472 LYM121 HI rice gbl70 OS12G026 20 2979 357 90.6 blastp 1473 LYM123 H4 barley gb 157 SOLEXA IAF268595 2980 358 85.5 blastp 1474 LYM123 H5 brachypodium 09vl G T761722 2981 358 84 blastp 1475 LYM123 H6 maize |gb 170|AI79555 8 2982 358 85.2 blastp 1476 LYM123 H7 sorghum 09v 1 SB06G 031680 2983 358 86.3 blastp 1477 LYM123 H4 wheat|gbl64|BE40187 1 2984 358 85.6 blastp 1478 LYM135 HI brachypodium 09vl D V480514 2985 359 93.1 blastp 1479 LYM135 H2 maize|gbl70|CB88566 7 2986 359 80.2 blastp 1480 LYM135 H3 sorghum 09v 1 SB 10G 007850 2987 359 84.1 blastp 1481 LYM138 H2 brachypodium 09vl G T810825 2988 360 84 blastp 1482 LYM138 H3 maize|gbl70|AI61233 3 2989 360 86.17 tblastn 1483 LYM138 H4 sorghum 09v 1 SB06G 031570 2990 360 86.33 tblastn 1484 LYM146 H2 brachypodium 09v 1 S RR031798S0143459 2991 361 84.3 blastp 1485 LYM146 H3 rice gbl70 OS03G217 30 2992 361 86.4 blastp 1486 LYM146 H4 sorghum 09v 1 SB01G 036160 2993 361 96 blastp 1487 LYM147 HO sorghum 09vl SB03G 003200 2994 362 82 blastp 1488 LYM154 HO wheat|gbl64|BE50057 1 2995 363 82.5 blastp 1489 LYM155 H3 brachypodium 09vl D V479969 2996 364 84.7 blastp 1489 LYM155 H3 brachypodium 09vl D V479969 2996 451 83.5 blastp 1490 LYM155 H4 rice gbl70 OS03G588 90 2997 364 81.3 blastp 1490 LYM155 H4 rice gbl70 OS03G588 90 2997 451 80 blastp 1491 LYM155 H3 wheat|gbl64|BQ80101 9 2998 364 92.3 blastp 1491 LYM155 H3 wheat|gbl64|BQ80101 9 2998 451 91.6 blastp 1492 LYM180 HO brachypodium 09vl D V473436 2999 365 82.9 blastp 1492 LYM180 HO brachypodium 09vl D V473436 2999 452 83.54 tblastn 2016213786 11 Aug 2016 101 Nucl. SEQ ID NO: Gene Name cluster name Polyp. SEQ ID NO: Homolog. to SEQ ID NO: % global identity Algor. 1493 LYM181 H3 brachypodium 09vl D V485149 3000 366 85.3 blastp 1493 LYM181 H3 brachypodium 09vl D V485149 3000 453 84.68 tblastn 1494 LYM181 H4 maize|gbl70|DR45221 6 3001 366 80.8 blastp 1494 LYM181 H4 maize|gbl70|DR45221 6 3001 453 81.25 tblastn 1495 LYM181 H5 rice gbl70 OS07G320 10 3002 366 82.8 blastp 1496 LYM181 H6 sorghum|09vl|SB02G 034110 3003 366 83.5 blastp 1497 LYM181 H2 wheat|gbl64|BE42537 7 3004 453 87.16 tblastn 1498 LYM181 H3 wheat|gbl64|BG90502 8 3005 453 93.58 tblastn 1499 LYM182 H8 brachypodium 09vl G T780326 3006 367 87.64 tblastn 1500 LYM182 H9 maize |gb 170|AI79573 7 3007 367 84.27 tblastn 1501 LYM182 H10 millet 09vlEVO454P M084568 3008 367 82.02 tblastn 1502 LYM182 HI 1 rice gbl70 OS04G333 00 3009 367 82.02 tblastn 1503 LYM182 H12 sorghum 09v 1 SB06G 015280 3010 367 83.15 tblastn 1504 LYM182 H13 sugarcane gbl57.3 CA 066047 3011 367 83.15 tblastn 1505 LYM182 H6 switchgrass gbl 67 FE6 10729 3012 367 82.02 tblastn 1506 LYM182 H7 switchgrass gb 167 FL6 99214 3013 367 83.15 tblastn 1507 LYM182 H8 wheat|gbl64|BF20013 6 3014 367 95.51 tblastn 1508 LYM184 H5 brachypodium 09vl D V476770 3015 454 82.68 tblastn 1509 LYM184 H6 brachypodium 09vl G T762544 3016 454 82.61 tblastn 1510 LYM184 H7 brachypodium 09v 1 S RR031799S0153720 3017 454 82.68 tblastn 1511 LYM184 H3 leymus gb 16 6 EG3 851 50 3018 454 84.8 blastp 1512 LYM184 H8 maize |gb 1701AI69121 0 3019 382 100 blastp 1512 LYM184 H8 maize |gb 1701AI69121 0 3019 454 80.87 tblastn 1513 LYM206 H2 sorghum 09vlSB07G 021090 3020 382 84.5 blastp 1513 LYM206 H2 sorghum 09vlSB07G 021090 3020 454 80.52 tblastn 1514 LYM184 H4 switchgrass gbl67 FL7 04827 3021 454 80.5 blastp 1515 LYM184 H5 wheat|gbl64|AL82125 4 3022 368 82.66 tblastn 2016213786 11 Aug 2016 102 Nucl. SEQ ID NO: Gene Name cluster name Polyp. SEQ ID NO: Homolog. to SEQ ID NO: % global identity Algor. 1515 LYM184 H5 wheat|gbl64|AL82125 4 3022 454 86.96 tblastn 1516 LYM185 HI pseudoroegneria gb 16 7IFF360278 3023 455 91.53 tblastn 1517 LYM185 H2 wheat gbl 64 BG90607 7 3024 455 85.31 tblastn 1518 LYM186 H4 brachypodium 09vl G T761126 3025 370 90.7 blastp 1519 LYM186 H5 maize|gbl70|BE55288 7 3026 370 82.5 tblastn 1520 LYM186 H6 rice gbl70 OS10G399 30 3027 370 86.3 blastp 1521 LYM186 H7 sorghum 09v 1 SB01G 030050 3028 370 86.5 blastp 1522 LYM186 H4 wheat|gbl64|BE42942 5 3029 370 97.6 blastp 1523 LYM188 H8 brachypodium 09vl D V475481 3030 371 92.4 blastp 1523 LYM188 H8 brachypodium 09vl D V475481 3030 456 89.41 tblastn 1524 LYM188 H9 maize|gbl70|AI62272 6 3031 371 87.2 blastp 1524 LYM188 H9 maize|gbl70|AI62272 6 3031 456 83.47 tblastn 1525 LYM188 H10 maize|gbl70|AW4248 65 3032 371 86 blastp 1525 LYM188 H10 maize|gbl70|AW4248 65 3032 456 83.9 tblastn 1526 LYM188 HI 1 millet 09vlEVO454P M011140 3033 456 85.17 tblastn 1527 LYM188 H3 pseudoroegneria gb 16 7IFF341644 3034 456 80.5 blastp 1528 LYM188 H12 rice gbl70 OS03G539 60 3035 371 88.2 blastp 1528 LYM188 H12 rice gbl70 OS03G539 60 3035 456 84.75 tblastn 1529 LYM188 H13 sorghum 09v 1 SB01G 007950 3036 371 87.4 blastp 1529 LYM188 H13 sorghum 09v 1 SB01G 007950 3036 456 84.32 tblastn 1530 LYM188 H14 sugarcane gbl57.3 BQ 530106 3037 371 87.4 blastp 1530 LYM188 H14 sugarcane gbl57.3 BQ 530106 3037 456 84.32 tblastn 1531 LYM188 H7 switchgrass gbl67 FL7 09807 3038 456 84.32 tblastn 1532 LYM188 H8 wheat gbl 64 CA74294 0 3039 456 81.78 tblastn 1533 LYM193 HI leymus gb 166 EG3 819 14 3040 459 87.1 tblastn 1534 LYM193 H2 wheat|gbl64|BQ23667 8 3041 459 85.26 tblastn 1535 LYM194 HO brachypodium 09v 1 S RR031796S0004815 3042 375 84.8 blastp 2016213786 11 Aug 2016 103 Nucl. SEQ ID NO: Gene Name cluster name Polyp. SEQ ID NO: Homolog. to SEQ ID NO: % global identity Algor. 1536 LYM194 HI maize|gbl70|BQ53910 2 3043 375 82.1 blastp 1537 LYM194 H2 sorghum 09v 1 SB06G 015320 3044 375 84.9 blastp 1538 LYM194 H3 switchgrass gbl67 FE6 45079 3045 375 82.9 blastp 1539 LYM194 H4 wheat|gbl 64|BE51807 8 3046 375 96.3 blastp 1540 LYM197 H2 sugarcane gbl57.3 BQ 536804 3047 377 88.57 tblastn 1541 LYM198 HI sorghum 09v 1 SBO1G 045460 3048 378 85.5 blastp 1542 LYM201 HI aquilegia gbl57.3 DR9 15888 3049 379 82.4 blastp 1543 LYM201 H19 arabidopsis lyrata|09vl |JGIAL022 871 3050 379 80.07 tblastn 1544 LYM201 H2 artemisia|gb 164|EY 03 3288 3051 379 80.5 blastp 1545 LYM201 H3 b rapa|gbl62|CV433700 3052 379 80.3 blastp 1546 LYM201 H20 brachypodium 09vl D V471345 3053 379 93.8 blastp 1547 LYM201 H21 brachypodium 09vl G T759255 3054 379 81.2 blastp 1548 LYM201 H22 cassava 09v 1 DQ1383 70 3055 379 82.2 blastp 1549 LYM201 H23 cassava 09vl FF38053 9 3056 379 81.3 blastp 1550 LYM201 H24 castorbean|09vl |EE25 6048 3057 379 81.4 blastp 1551 LYM201 H25 che stnut gb170 S RR0 0 6295S0006313 3058 379 80.6 blastp 1552 LYM201 H7 cotton|gbl64|AI72837 8 3059 379 81.7 blastp 1553 LYM201 H8 cotton gb 164 C00709 70 3060 379 82 blastp 1554 LYM201 H26 cucumber 09vl AM73 1598 3061 379 81.7 blastp 1555 LYM201 H27 lotus 09vlBI41943 7 3062 379 80.5 blastp 1556 LYM201 H28 maize|gbl70|AI97825 4 3063 379 98.2 blastp 1557 LYM201 H29 maize|gbl70|DR97111 8 3064 379 80.1 blastp 1558 LYM201 H30 medicago 09v 1 AW68 4099 3065 379 80.7 blastp 1559 LYM201 H31 oakgbl70 CU656181 3066 379 82.56 tblastn 1560 LYM201 H32 poplar|gb 170|BI06963 7 3067 379 81.3 blastp 1561 LYM201 H33 poplar|gbl70|BU8871 51 3068 379 80.7 blastp 2016213786 11 Aug 2016 104 Nucl. SEQ ID NO: Gene Name cluster name Polyp. SEQ ID NO: Homolog. to SEQ ID NO: % global identity Algor. 1562 LYM201 H34 rice gbl70 OS02G345 60 3069 379 95.2 blastp 1563 LYM201 H35 solanum phurej a| 09v 11SPHBG1 23984 3070 379 81.4 blastp 1564 LYM201 H36 solanum phurej a| 09v 11 SPHBG 1 29477 3071 379 81.2 blastp 1565 LYM201 H37 sorghum 09v 1 SB04G 022350 3072 379 98.4 blastp 1566 LYM201 H15 soybean gb 168 AL3 67 670 3073 379 80.7 blastp 1567 LYM201 H16 soybean gbl 68 AW68 4099 3074 379 80.5 blastp 1568 LYM201 H38 sugarcane gbl57.3 CA 065291 3075 379 98.6 blastp 1569 LYM201 H18 switchgrass gbl 67 FE6 41755 3076 379 98.2 blastp 1570 LYM201 H39 tomato|09vl|BG12398 4 3077 379 81.4 blastp 1571 LYM201 H40 tomato|09vl|BG12947 7 3078 379 81.2 blastp 1572 LYM201 H19 wheat|gbl64|BE40316 8 3079 379 93.2 blastp 1573 LYM203 H9 barley gb 157 SOLEXA IBI949918 3080 380 84.7 blastp 1574 LYM203 H10 lolium|09vl|AU24700 9 3081 380 85.2 blastp 1575 LYM203 HI 1 maize|gbl70|AI62967 5 3082 380 95.7 blastp 1576 LYM203 H12 millet 09vlEVO454P M058394 3083 380 81.7 blastp 1577 LYM203 H13 rice gbl70 OS02G083 80 3084 380 89.2 blastp 1578 LYM203 H14 sorghum 09v 1 SB04G 005460 3085 380 96.8 blastp 1579 LYM203 H15 sugarcane gbl57.3 CA 119568 3086 380 94.1 blastp 1580 LYM203 H6 switchgrass gb 167 DN 142920 3087 380 95.2 blastp 1581 LYM203 H7 switchgrass gb 167 FE6 17741 3088 380 95.7 blastp 1582 LYM203 H8 wheat|gbl64|BQ80196 6 3089 380 85.7 blastp 1583 LYM203 H9 wheat|gbl64|BQ90323 0 3090 380 86.2 blastp 1584 LYM206 H3 maize|gbl70|AW0559 97 3091 382 84.1 blastp 1585 LYM207 H2 maize|gbl70|BM3402 89 3092 383 86.5 blastp 1586 LYM207 H3 sorghum 09v 1 SB06G 023870 3093 383 94.3 blastp 1587 LYM207 H2 switchgrass gbl67 FE6 01320 3094 383 82.3 blastp 2016213786 11 Aug 2016 1611 1610 1609 1608 1608 1607 1607 1606 1606 1605 1604 1603 1602 1601 1600 1599 1598 1597 1596 1595 1594 1593 1592 1591 1590 1589 1588 Nucl. SEQ ID NO: LYM224 H2 LYM224 H3 LYM224 H2 LYM221 H3 LYM221 H3 LYM221 H2 LYM221 H2 LYM221 HI LYM221 HI LYM217 H3 LYM217 H4 LYM217 H3 LYM215 H2 LYM213 H2 LYM213 HI LYM212 H6 LYM212 H10 LYM212 H9 LYM212 H8 LYM212 H7 LYM212 H6 LYM208 H6 r o 00 r o 00 r o 00 LYM208 H7 LYM208 H6 Gene Name switchgrass gbl 67 FE6 17506 sorghum|09vl|SB02G 040000 brachypodium 09vl G T762108 sorghum 09v 1 SBO1G 034610 sorghum 09v 1 SBO 1G 034610 rice gbl70 OS03G248 70 rice gbl70 OS03G248 70 brachypodium 09vl G T792319 brachypodium 09vl G T792319 ZPP90 933\L9\°fi ssmgrpitAYS sugarcane gbl57.3 CA 136491 sorghum 09v 1 SBO 1G 043910 98081 933\L9\°fi ssmStpiiMS sorghum 09v 1 SB06G 018770 maize|gbl70|AW2822 49 wheat|gbl64|BE40224 2 sugarcane gbl57.3 CA 088789 sorghum 09v 1 SBO 1G 045480 o' o CTQ σ' •o H- 0 Ο o GO O o o •o SO maize|gbl70|AI67747 4 barley gb 157 SOLEXA IBF623682 switchgrass gbl67 FL7 29765 6Z9Z\ 933\L9\°fi ssmgqoirMS sorghum|09v 1 |SB08G 002510 sorghum 09vlSB01G 032070 rice gbl70 OS09G016 90 maize |gb 1701AI69136 8 cluster name 3118 3117 3116 3115 3115 3114 3114 3113 3113 3112 3111 3110 3109 3108 3107 3106 3105 3104 3103 3102 3101 3100 3099 3098 3097 3096 3095 Polyp. SEQ ID NO: 393 393 393 461 391 461 391 461 391 OO 00 00 00 00 00 387 386 386 385 385 385 385 385 385 384 384 384 384 384 384 Homolog. to SEQ ID NO: 00 so 92.9 82.4 88.7 90.7 80.5 82.9 00 83.8 86.7 00 <1 88.2 90.42 91.7 90.9 00 © OO 92 92.5 00 O 88.5 00 p 90.4 90.4 86.6 YZ6 82 94.4 % global identity tblastn blastp blastp blastp blastp blastp blastp blastp blastp blastp blastp blastp tblastn blastp blastp tblastn blastp blastp tblastn blastp blastp blastp blastp blastp blastp blastp blastp Algor. 2016213786 11 Aug 2016 106 Nucl. SEQ ID NO: Gene Name cluster name Polyp. SEQ ID NO: Homolog. to SEQ ID NO: % global identity Algor. 1612 LYM227 HI sorghum 09v 1 SBO1G 043140 3119 394 88.3 blastp 1613 LYM228 HI sorghum 09vl SB09G 006910 3120 395 85 blastp 1613 LYM228 HI sorghum 09vl SB09G 006910 3120 462 83.7 blastp 1614 LYM232 H3 sorghum|09vl|SB02G 000450 3121 396 80.4 blastp 1615 LYM232 H4 sugarcane gbl57.3 CA 073189 3122 396 80.8 blastp 1616 LYM232 H3 switchgrass gbl 67 FL8 49399 3123 396 80.7 blastp 1617 LYM233 HO brachypodium 09v 1 T MPLOS01G70020T1 3124 397 99.6 blastp 1618 LYM234 HO rice gbl70 OS07G382 90 3125 398 81.3 blastp 1619 LYM236 H99 apple|gbl 71 |CN48856 8 3126 399 89.1 blastp 1620 LYM236 H100 apple|gbl 71 |CN88310 0 3127 399 89.6 blastp 1621 LYM236 H3 aquilegia gbl57.3 DR9 19774 3128 399 87.4 blastp 1622 LYM236 H101 arabidopsis lyrata|09vl |JGIAL005 113 3129 399 83.9 blastp 1623 LYM236 H102 arabidopsis lyrata|09vl |JGIAL006 646 3130 399 86.89 tblastn 1624 LYM236 H4 arabidopsis gb 165 AT 1G54340 3131 399 83.5 blastp 1625 LYM236 H5 arabidopsis gb 165 AT 1G65930 3132 399 87.1 blastp 1626 LYM236 H6 artemisia|gb 164|EY 03 4635 3133 399 87.9 blastp 1627 LYM236 H7 avocado gbl64 C0995 120 3134 399 91.3 blastp 1628 LYM236 H8 b oleracea gb 161 DY028 218 3135 399 87.2 blastp 1629 LYM236 H9 b rapa|gbl62|CX269094 3136 399 87.2 blastp 1630 LYM236 H10 b rapa|gbl62|GFXAF25 8246X1 3137 399 84.3 tblastn 1631 LYM236 HI 1 b rapa|gbl62|L47856 3138 399 87.2 blastp 1632 LYM236 H103 barley gb 157 SOLEXA IAL502504 3139 399 89.3 blastp 1633 LYM236 H13 basilicum gb 157.3 DY 322368 3140 399 87.7 blastp 1634 LYM236 H14 beangbl67 CA896841 3141 399 87.9 blastp 1635 LYM236 H104 brachypodium 09vl D V478973 3142 399 85.3 blastp 2016213786 11 Aug 2016 107 Nucl. SEQ ID NO: Gene Name cluster name Polyp. SEQ ID NO: Homolog. to SEQ ID NO: % global identity Algor. 1636 LYM236 H105 brachypodium 09vl D V482439 3143 399 90.5 blastp 1637 LYM236 H17 cacao|gbl67|DQ44887 5 3144 399 89.2 blastp 1638 LYM236 H18 canola|gb 161 |BQ7049 58 3145 399 87.2 blastp 1639 LYM236 H19 canola|gbl61|CD8173 40 3146 399 87.2 blastp 1640 LYM236 H20 canola|gbl61|CD8331 08 3147 399 83.9 blastp 1641 LYM236 H21 canola|gbl61|CX1894 42 3148 399 86.5 blastp 1642 LYM236 H22 canola|gbl61|DY0113 90 3149 399 87.2 blastp 1643 LYM236 H106 cassava|09vl|CK6426 10 3150 399 90.1 blastp 1644 LYM236 H107 cassava 09vl DV4579 42 3151 399 87.5 blastp 1645 LYM236 H108 castorbean|09vl |EE25 6632 3152 399 86.1 blastp 1646 LYM236 H109 castorbean|09vl |EE25 9479 3153 399 90.6 blastp 1647 LYM236 H26 centaurea|gbl66|EH73 1203 3154 399 81.2 blastp 1648 LYM236 H27 centaurea|gb 166|EL93 2337 3155 399 86.6 blastp 1649 LYM236 H110 che stnut gb170 S RRO 0 6295S0002580 3156 399 82.27 tblastn 1650 LYM236 Hill che stnut gb170 S RRO 0 6295S0002701 3157 399 89.6 blastp 1651 LYM236 H112 cichorium|gbl71 |EH6 75189 3158 399 87.3 blastp 1652 LYM236 H113 cichorium|gbl71 |EH6 83726 3159 399 89.1 blastp 1653 LYM236 H30 citrus|gbl66|AF 17666 9 3160 399 90.6 blastp 1654 LYM236 H31 citrus|gbl66|CD57391 1 3161 399 85.1 blastp 1655 LYM236 H32 coffea|gbl57.2|DV663 279 3162 399 87.8 blastp 1656 LYM236 H33 cotton|gbl64|AI72726 0 3163 399 87.2 blastp 1657 LYM236 H34 cotton|gbl64|BF27858 8 3164 399 83.5 blastp 1658 LYM236 H35 cowpea gb 166 FC45 81 36 3165 399 89.1 blastp 1659 LYM236 H36 cynara|gbl67|GE5772 43 3166 399 86.47 tblastn 1660 LYM236 H37 cynara|gbl67|GE5796 63 3167 399 88.6 blastp 1661 LYM236 H38 dandelion gb 161 DY 8 04243 3168 399 86.96 tblastn 1662 LYM236 H39 eucalyptus gb 166 X97 063 3169 399 88 blastp 2016213786 11 Aug 2016 108 Nucl. SEQ ID NO: Gene Name cluster name Polyp. SEQ ID NO: Homolog. to SEQ ID NO: % global identity Algor. 1663 LYM236 H40 fescue gb 161 CK8010 45 3170 399 89.8 blastp 1664 LYM236 H41 fescue gbl61DT6747 24 3171 399 90 blastp 1665 LYM236 H42 ginger|gbl64|DY3602 89 3172 399 91.3 blastp 1666 LYM236 H43 grape|gbl60|BM43675 5 3173 399 89.9 blastp 1667 LYM236 H44 kiwi|gbl66|FG396670 3174 399 88.2 blastp 1668 LYM236 H45 kiwi gbl66FG397107 3175 399 88.7 blastp 1669 LYM236 H46 kiwigbl66 FG397291 3176 399 89.4 blastp 1670 LYM236 H47 lettuce gbl 57.2 DW08 8948 3177 399 87.4 blastp 1671 LYM236 H48 leymus gbl66 CD8091 60 3178 399 89.6 blastp 1672 LYM236 H49 liriodendron|gbl66|CK 762229 3179 399 88.2 blastp 1673 LYM236 H114 lotus|09vl|AW428686 3180 399 89.4 blastp 1674 LYM236 H115 lotus 09v 1 BP03 3 879 3181 399 83.7 blastp 1675 LYM236 H51 lovegrass gbl67DN48 0596 3182 399 90.8 blastp 1676 LYM236 H116 maize|gbl70|AI60081 5 3183 399 93.7 blastp 1677 LYM236 H117 maize|gbl70|AW3132 97 3184 399 92.2 blastp 1678 LYM236 H118 maize|gbl70|W21690 3185 399 91.3 blastp 1679 LYM236 H119 medicago 09v 1 AW 19 1201 3186 399 88.2 blastp 1680 LYM236 H120 medicago 09v 1 AW68 9032 3187 399 84.9 blastp 1681 LYM236 H121 millet 09vlCD725798 3188 399 92.5 blastp 1682 LYM236 H122 millet 09vlEVO454P M002708 3189 399 94.2 blastp 1683 LYM236 H123 monkeyflower|09vl |D V206036 3190 399 87.4 blastp 1684 LYM236 H56 nicotiana benthamiana|gb 162|C K291144 3191 399 86.5 blastp 1685 LYM236 H57 oil palm|gbl66|EL684429 3192 399 87.3 blastp 1686 LYM236 H124 peanut gb 171 CD03 86 82 3193 399 87.9 blastp 1687 LYM236 H125 pea|09vl|CD860585 3194 399 89.6 blastp 1688 LYM236 H126 pepper gb 171 BM0617 61 3195 399 88 blastp 2016213786 11 Aug 2016 109 Nucl. SEQ ID NO: Gene Name cluster name Polyp. SEQ ID NO: Homolog. to SEQ ID NO: % global identity Algor. 1689 LYM236 H127 pepper gb 171 CA5165 82 3196 399 85.3 blastp 1690 LYM236 H128 petunia gbl 71 DC2402 08 3197 399 88.2 blastp 1691 LYM236 H129 physcomitrella| 1 Ον 11A W497149 3198 399 82.2 blastp 1692 LYM236 H62 pine|gbl57.2|AW0102 92 3199 399 85.6 blastp 1693 LYM236 H63 pine|gbl57.2|BX2498 26 3200 399 85.6 blastp 1694 LYM236 H130 poplar gb 170 AI16195 6 3201 399 89.6 blastp 1695 LYM236 H131 poplar gbl70BI12770 6 3202 399 86.6 blastp 1696 LYM236 H132 poplar|gb 170|BI 13161 0 3203 399 86.8 blastp 1697 LYM236 H133 poplar|gbl70|BU8210 63 3204 399 90.4 blastp 1698 LYM236 H66 potato gbl57.2 BG591 093 3205 399 88 blastp 1699 LYM236 H67 prunusgbl67AF3674 43 3206 399 89.4 blastp 1700 LYM236 H68 radish|gbl64|EV52684 7 3207 399 85.8 blastp 1701 LYM236 H69 radish|gbl64|EV53122 5 3208 399 86.9 blastp 1702 LYM236 H134 rice gbl70 OS01G145 80 3209 399 84.8 blastp 1703 LYM236 H135 rice gbl70 OS01G466 10 3210 399 93 blastp 1704 LYM236 H72 rye|gbl64|BE494776 3211 399 86.17 tblastn 1705 LYM236 H73 safflower gbl62 EL37 2795 3212 399 87.3 blastp 1706 LYM236 H74 safflower gbl62 EL37 4725 3213 399 89.1 blastp 1707 LYM236 H136 solanum phurej a| 09v 11SPHBG1 31802 3214 399 86.3 blastp 1708 LYM236 H137 solanum phurej a| 09v 11SPHBG6 29432 3215 399 87.7 blastp 1709 LYM236 H138 sorghum 09vl SB03G 029840 3216 399 92 blastp 1710 LYM236 H139 sorghum 09vl SB09G 029110 3217 399 94.7 blastp 1711 LYM236 H77 soybean gbl68 AW25 7518 3218 399 88.7 blastp 1712 LYM236 H78 soybean gbl68 AW68 9032 3219 399 85.6 blastp 1713 LYM236 H79 soybean gbl68 FF554 826 3220 399 84.7 blastp 1714 LYM236 H80 soybean gb 168 SOYID H 3221 399 89.4 blastp 2016213786 11 Aug 2016 110 Nucl. SEQ ID NO: Gene Name cluster name Polyp. SEQ ID NO: Homolog. to SEQ ID NO: % global identity Algor. 1715 LYM236 H81 spikemoss gbl 65 FE44 1231 3222 399 84.2 blastp 1716 LYM236 H82 spikemoss gb 165 FE44 3181 3223 399 82.3 blastp 1717 LYM236 H83 spruce gb 162 C02258 56 3224 399 85 blastp 1718 LYM236 H84 strawberry gbl64 DV4 38767 3225 399 82.6 blastp 1719 LYM236 H140 sugarcane gbl57.3BU 103347 3226 399 94.5 blastp 1720 LYM236 H141 sugarcane gbl57.3 CA 070718 3227 399 92.5 blastp 1721 LYM236 H87 sunflower gb 162 CD8 46861 3228 399 86.6 blastp 1722 LYM236 H88 sunflower gb 162 CD8 54278 3229 399 87.9 blastp 1723 LYM236 H89 switchgrass gb 167 DN 142415 3230 399 92 blastp 1724 LYM236 H90 switchgrass gb 167 DN 143508 3231 399 95.4 blastp 1725 LYM236 H91 switchgrass gb 167 DN 150237 3232 399 95.2 blastp 1726 LYM236 H92 switchgrass gb 167 DN 151575 3233 399 92.2 blastp 1727 LYM236 H93 thellungiella|gb 167|D N774112 3234 399 87.14 tblastn 1728 LYM236 H94 tobacco|gbl62|DV158 343 3235 399 83.3 blastp 1729 LYM236 H95 tobacco gbl62 X77944 3236 399 88.5 blastp 1730 LYM236 H142 tomato|09vl|BG13180 2 3237 399 85.6 blastp 1731 LYM236 H143 tomato|09vl |BG62943 2 3238 399 87.3 blastp 1732 LYM236 H98 triphysaria|gbl64|DRl 71747 3239 399 88.4 blastp 1733 LYM236 H99 wheat|gbl64|BE44254 0 3240 399 84.1 blastp 1734 LYM238 HO rice gbl70 OS05G450 80 3241 400 95.4 blastp 1735 LYM240 H9 barley gb 157 SOLEXA IAL508021 3242 402 91.9 blastp 1736 LYM240 H10 brachypodium 09vl G T810642 3243 402 91.9 blastp 1737 LYM240 HI 1 maize gbl70 DR97279 0 3244 402 84.2 blastp 1738 LYM240 H12 sorghum| 09v 11SB02G 038240 3245 402 84.2 blastp 1739 LYM240 H13 sugarcane gbl57.3 CA 075929 3246 402 82.3 blastp 1740 LYM240 H6 switchgrass gbl 67 FE5 97498 3247 402 81.6 blastp 1741 LYM240 H7 switchgrass gb 167 FE6 10847 3248 402 80 blastp 2016213786 11 Aug 2016 111 Nucl. SEQ ID NO: Gene Name cluster name Polyp. SEQ ID NO: Homolog. to SEQ ID NO: % global identity Algor. 1742 LYM240 H8 switchgrass gbl 67 FL9 60804 3249 402 81.6 blastp 1743 LYM240 H9 wheat gbl 64 CA67449 1 3250 402 89.93 tblastn 1744 LYM242 H7 barley gb 157 SOLEXA IBE412570 3251 404 82.2 blastp 1745 LYM242 H8 brachypodium 09vl G T764573 3252 404 86.1 blastp 1746 LYM242 H9 maize|gbl70|AI74605 3 3253 404 83.4 blastp 1747 LYM242 H10 millet 09vlEVO454P M008771 3254 404 85 blastp 1748 LYM242 HI 1 sorghum| 09v 11SB03G 003160 3255 404 82.6 blastp 1749 LYM242 H12 sugarcane gbl57.3BQ 534251 3256 404 83.8 blastp 1750 LYM242 H5 switchgrass gb167 DN 143169 3257 404 85.1 blastp 1751 LYM242 H6 switchgrass gb 167 FE6 54179 3258 404 85 blastp 1752 LYM242 H7 wheat|gbl64|BE40328 5 3259 404 82.6 blastp 1753 LYM248 H3 brachypodium 09vl G T773582 3260 407 84.5 blastp 1754 LYM248 H4 maize|gbl70|AI96695 7 3261 407 88.5 blastp 1755 LYM248 H5 sorghum 09vl SB04G 000645 3262 407 88.2 blastp 1756 LYM248 H2 switchgrass gb 167 DN 149511 3263 407 81.1 blastp 1757 LYM248 H3 wheat|gbl64|BE41803 3 3264 407 84.89 tblastn 1758 LYM250 HO rice gbl70 OS09G387 00 3265 409 100 tblastn 1758 LYM250 HO rice gbl70 OS09G387 00 3265 463 97.78 tblastn 1759 LYM251 HI antirrhinum|gb 166| AJ5 60114 3266 410 82 blastp 1760 LYM251 H76 apple gbl71 CN49264 3 3267 410 80.1 blastp 1761 LYM251 H77 arabidopsis lyrata|09vl | JGIAL012 198 3268 410 81.4 blastp 1762 LYM251 H3 arabidopsis gb 165 AT 2G17380 3269 410 80.7 blastp 1763 LYM251 H4 arabidopsis gb 165 AT 4G35410 3270 410 80.12 tblastn 1764 LYM251 H5 b olerace a gb 161 AM 3 8 5265 3271 410 81.4 blastp 1765 LYM251 H6 b rapa|gbl62|L33527 3272 410 81.4 blastp 1766 LYM251 H7 banana|gbl67|FF5583 00 3273 410 81.37 tblastn 2016213786 11 Aug 2016 112 Nucl. SEQ ID NO: Gene Name cluster name Polyp. SEQ ID NO: Homolog. to SEQ ID NO: % global identity Algor. 1767 LYM251 H78 barley gb 157 SOLEXA IBE421807 3274 410 81.4 blastp 1768 LYM251 H9 basilicum gb 157.3 DY 343154 3275 410 80.12 tblastn 1769 LYM251 HI 1 beangbl67 CV536707 3276 410 80.1 blastp 1770 LYM251 H79 brachypodium 09vl D V469153 3277 410 82.6 blastp 1771 LYM251 H13 canola|gb 161 |CN7260 86 3278 410 81.4 blastp 1772 LYM251 H80 cassava 09vl CK6504 27 3279 410 80.12 tblastn 1773 LYM251 H81 cassava 09vl DV4488 85 3280 410 81.4 blastp 1774 LYM251 H82 castorbean 09vl XMO 02514342 3281 410 81.4 blastp 1775 LYM251 H16 c atharanthus | gb 1661E G554670 3282 410 81.4 blastp 1776 LYM251 H17 centaurea|gbl66|EH73 7707 3283 410 81.4 blastp 1777 LYM251 H18 centaurea|gbl66|EH78 2010 3284 410 81.4 blastp 1778 LYM251 H83 che stnut gb 17 0 S RRO 0 6295S0001854 3285 410 80.1 blastp 1779 LYM251 H84 chickpea|09v2| D Y 475 463 3286 410 80.12 tblastn 1780 LYM251 H85 cichorium|gbl71 |EH6 77909 3287 410 81.4 blastp 1781 LYM251 H86 cichorium|gbl71 |EH6 81849 3288 410 80.7 blastp 1782 LYM251 H21 citrus|gbl66|CF41901 5 3289 410 82 blastp 1783 LYM251 H22 clover|gbl62|BB93513 6 3290 410 81.4 blastp 1784 LYM251 H23 cowpeagbl66 FF3837 63 3291 410 80.1 blastp 1785 LYM251 H87 cucumber 09vl CKO 85 508 3292 410 80.1 blastp 1786 LYM251 H24 dandelion gb 161 DY 8 22878 3293 410 80.1 blastp 1787 LYM251 H25 eucalyptus gbl66 CT9 81708 3294 410 80.7 blastp 1788 LYM251 H88 femgbl71 DK949355 3295 410 80.1 blastp 1789 LYM251 H26 fescue gbl61DT7028 20 3296 410 82.6 blastp 1790 LYM251 H89 gerbera|09vl|AJ75631 9 3297 410 80.7 blastp 1791 LYM251 H27 grape|gbl60|CB00819 1 3298 410 82 blastp 1792 LYM251 H28 grape|gbl60|CD79981 9 3299 410 82 blastp 1793 LYM251 H29 ipomoea gbl 57.2 CJ75 1066 3300 410 81.4 blastp 2016213786 11 Aug 2016 113 Nucl. SEQ ID NO: Gene Name cluster name Polyp. SEQ ID NO: Homolog. to SEQ ID NO: % global identity Algor. 1794 LYM251 H90 jatropha|09vl |G02471 40 3301 410 80.7 blastp 1795 LYM251 H30 lettuce gbl57.2 DW04 5452 3302 410 81.4 blastp 1796 LYM251 H31 liriodendron|gbl66|CK 762515 3303 410 83.2 blastp 1797 LYM251 H91 maize|gbl70|AA97985 6 3304 410 83.23 tblastn 1798 LYM251 H92 maize|gbl70|AI61934 2 3305 410 83.2 blastp 1799 LYM251 H93 maize|gbl70|AW1344 57 3306 410 91.3 tblastn 1800 LYM251 H94 medicago 09vl MSU9 3094 3307 410 82 blastp 1801 LYM251 H36 melon|gbl65|DV6335 83 3308 410 80.1 blastp 1802 LYM251 H95 millet 09vlEVO454P M010186 3309 410 83.2 blastp 1803 LYM251 H96 millet 09vlEVO454P M104784 3310 410 91.93 tblastn 1804 LYM251 H97 monkeyflower|09vl |G R007448 3311 410 82.6 blastp 1805 LYM251 H37 nuphar | gb 16 61DT5 8 85 73 3312 410 82 blastp 1806 LYM251 H98 oak|gbl70|DN949793 3313 410 80.1 blastp 1807 LYM251 H38 papaya|gbl65|EX2615 60 3314 410 81.4 blastp 1808 LYM251 H99 peanut|gbl 71 |EH0468 45 3315 410 82 blastp 1809 LYM251 H100 pepper gbl71BM0682 91 3316 410 83.2 blastp 1810 LYM251 H101 petunia gbl71 FN0050 56 3317 410 82.6 blastp 1811 LYM251 H42 pine|gbl57.2|AA5568 57 3318 410 81.4 blastp 1812 LYM251 H43 pine|gbl57.2|AW2898 37 3319 410 81.4 blastp 1813 LYM251 H102 poplar|gbl70|AI16513 0 3320 410 80.1 blastp 1814 LYM251 H45 poppy gbl66FG61376 3 3321 410 80.1 blastp 1815 LYM251 H46 potato|gbl57.2|BF054 079 3322 410 82.6 blastp 1816 LYM251 H47 pseudoroegneria gb 16 7IFF342572 3323 410 80.7 blastp 1817 LYM251 H48 radish|gbl64|EV52520 6 3324 410 80.7 blastp 1818 LYM251 H49 radish|gbl64|EV52859 3 3325 410 80.7 blastp 1819 LYM251 H50 radish|gbl64|EV53499 6 3326 410 81.4 blastp 1820 LYM251 H51 radish|gbl64|EV56567 7 3327 410 81.4 blastp 2016213786 11 Aug 2016 114 Nucl. SEQ ID NO: Gene Name cluster name Polyp. SEQ ID NO: Homolog. to SEQ ID NO: % global identity Algor. 1821 LYM251 H103 rice gbl70 OS03G570 40 3328 410 82.6 blastp 1822 LYM251 H53 rye|gbl64|BE637009 3329 410 80.7 blastp 1823 LYM251 H54 safflower|gbl62|EL40 2398 3330 410 81.4 blastp 1824 LYM251 H104 solanum phurej a| 09v 11SPHBG1 26373 3331 410 82.6 blastp 1825 LYM251 H105 sorghum 09v 1 SBO1G 003840 3332 410 91.3 tblastn 1826 LYM251 H106 sorghum 09v 1 SBO 1G 006180 3333 410 83.2 blastp 1827 LYM251 H57 soybean gbl 68 AW68 5285 3334 410 81.4 blastp 1828 LYM251 H58 soybean gbl68 BQ154 723 3335 410 80.1 blastp 1829 LYM251 H59 spruce gb 162 Z93 754 3336 410 80.7 blastp 1830 LYM251 H107 sugarcane gbl57.3BQ 533200 3337 410 83.2 blastp 1831 LYM251 H108 sugarcane gbl57.3 BU 103624 3338 410 83.2 blastp 1832 LYM251 H62 sunflower gb 162 CD8 54801 3339 410 81.4 blastp 1833 LYM251 H63 sunflower gbl62 DY9 17387 3340 410 81.4 blastp 1834 LYM251 H64 sunflower gb 162 EL4 8 5634 3341 410 81.4 blastp 1835 LYM251 H65 switchgrass gb 167 DN 152225 3342 410 83.2 blastp 1836 LYM251 H66 switchgrass gb 167 DN 152580 3343 410 82 blastp 1837 LYM251 H67 switchgrass gbl 67 FL8 27716 3344 410 92.5 blastp 1838 LYM251 H68 thellungiella gb 167 D N776639 3345 410 80.7 blastp 1839 LYM251 H69 tobacco gbl62CV020 782 3346 410 82 blastp 1840 LYM251 H109 tomato|09vl|BG12637 3 3347 410 83.2 blastp 1841 LYM251 H71 triphysaria|gbl 64|EY 0 17996 3348 410 80.7 blastp 1842 LYM251 H72 walnuts gbl66 EL8929 83 3349 410 80.1 blastp 1843 LYM251 H73 walnuts gb 16 6 EL9034 96 3350 410 80.1 blastp 1844 LYM251 H74 wheat|gbl64|BE44435 6 3351 410 81.4 blastp 1845 LYM251 H75 wheat|gbl64|BE49857 9 3352 410 81.4 blastp 1846 LYM251 H76 wheat|gbl64|BQ90530 8 3353 410 81.4 blastp 2016213786 11 Aug 2016 115 Nucl. SEQ ID NO: Gene Name cluster name Polyp. SEQ ID NO: Homolog. to SEQ ID NO: % global identity Algor. 1847 LYM255 H3 brachypodium 09vl D V486276 3354 413 83.9 blastp 1848 LYM255 H4 maize|gbl70|AA07244 6 3355 413 80.8 blastp 1849 LYM255 H5 sorghum 09vl SB04G 034000 3356 413 82 blastp 1850 LYM255 H3 switchgrass gbl 67 FE6 06184 3357 413 83.8 blastp 1851 LYM260 HO rice gbl70 OS09G388 00 3358 414 80.5 blastp 1852 LYM263 HO maize|gbl70|AI67385 9 3359 416 87.47 tblastn 1853 LYM183 H8 brachypodium 09vl D V474476 3360 417 90.5 blastp 1853 LYM183 H8 brachypodium 09vl D V474476 3360 464 90.5 blastp 1854 LYM183 HI cenchrus|gbl66|EB655 853 3361 417 83.5 blastp 1854 LYM183 HI cenchrus|gbl66|EB655 853 3361 464 83.5 blastp 1855 LYM183 H2 leymusgbl66 EG3757 19 3362 417 94.2 blastp 1855 LYM183 H2 leymusgbl66 EG3757 19 3362 464 94.2 blastp 1856 LYM183 H9 maize | gb 17 01AI96467 3 3363 417 85.2 blastp 1856 LYM183 H9 maize | gb 17 01AI96467 3 3363 464 85.2 blastp 1857 LYM183 H10 rice gb 170 OS03G607 80 3364 417 84.8 blastp 1857 LYM183 H10 rice gb 170 OS03G607 80 3364 464 84.8 blastp 1858 LYM183 HI 1 sorghum 09v 1 SB01G 003070 3365 417 84.4 blastp 1858 LYM183 HI 1 sorghum 09v 1 SB01G 003070 3365 464 84.4 blastp 1859 LYM183 H12 sugarcane gbl57.3 CA 111823 3366 417 83.6 blastp 1859 LYM183 H12 sugarcane gbl57.3 CA 111823 3366 464 83.6 blastp 1860 LYM183 H6 switchgrass gb 167 DN 151763 3367 417 83.4 blastp 1860 LYM183 H6 switchgrass gb 167 DN 151763 3367 464 83.4 blastp 1861 LYM183 H7 wheat|gbl64|BE51561 6 3368 417 93.9 tblastn 1861 LYM183 H7 wheat|gbl64|BE51561 6 3368 464 93.63 tblastn 1862 LYM183 H8 wheat|gbl64|BQ 16080 3 3369 417 94.7 blastp 1862 LYM183 H8 wheat|gbl64|BQ 16080 3 3369 464 94.7 blastp 1863 LYM256 H2 rice gbl70 OS05G451 10 3370 418 87.3 blastp 2016213786 11 Aug 2016 116 Nucl. SEQ ID NO: Gene Name cluster name Polyp. SEQ ID NO: Homolog. to SEQ ID NO: % global identity Algor. 1864 LYM256 H3 rice gbl70 OS10G079 70 3371 418 81.09 tblastn 1865 LYM200 HO sorghum 09vl SB04G 005600 3372 419 86.5 blastp 1866 LYM267 HI sorghum 09v 1 SBO1G 044240 3373 420 88.3 blastp 1867 LYM268 HI sugarcane gbl57.3 CA 079076 3374 421 81.6 blastp 1868 LYM270 HO sorghum|09vl|SB02G 040045 3375 422 82.3 blastp 1869 LYM271 H7 barley gb 157 SOLEXA IBG344953 3376 423 89.9 blastp 1870 LYM271 H8 brachypodium 09vl G T838823 3377 423 89.9 blastp 1871 LYM271 H9 rice gbl70 OS07G434 60 3378 423 91.1 blastp 1872 LYM271 H10 sorghum| 09v 11SB02G 040020 3379 423 96.5 blastp 1873 LYM271 HI 1 sugarcane gbl57.3 CA 118167 3380 423 89.53 tblastn 1874 LYM271 H6 switchgrass gbl 67 FL6 91032 3381 423 94.2 blastp 1875 LYM271 H7 wheat|gbl64|CJ66420 9 3382 423 91.5 blastp 1876 LYM273 H4 brachypodium 09vl D V469687 3383 425 83.3 blastp 1877 LYM273 H5 maize|gbl70|AW3559 78 3384 425 85.2 blastp 1878 LYM273 H6 sorghum 09vl SB03G 044410 3385 425 84 blastp 1879 LYM273 H4 wheat|gbl 64|BE51837 7 3386 425 85 blastp 1880 LYM274 HO rice gbl70 OS01G702 40 3387 426 100 blastp 1880 LYM274 HO rice gbl70 OS01G702 40 3387 466 89.2 blastp 1881 LYM278 H9 maize | gb 17 01LLDQ24 4681 3388 428 95.2 blastp 1882 LYM278 H2 rye|gbl64|Z23257 3389 428 92.86 tblastn 1883 LYM278 H3 wheat|gbl64|AL82126 4 3390 428 95.3 blastp 1884 LYM278 H4 wheat|gbl64|BE51672 3 3391 428 94 blastp 1885 LYM278 H5 wheat|gbl64|BF20040 2 3392 428 86.9 tblastn 1886 LYM278 H6 wheat|gbl64|BF47442 3 3393 428 92.86 tblastn 1887 LYM278 H7 wheat gbl 64 BG90946 2 3394 428 89.3 blastp 1888 LYM278 H8 wheat gbl 64 BQ57909 7 3395 428 95.24 tblastn 1889 LYM278 H9 wheat|gbl64|CA65034 9 3396 428 83.3 blastp 2016213786 11 Aug 2016 117 Nucl. SEQ ID NO: Gene Name cluster name Polyp. SEQ ID NO: Homolog. to SEQ ID NO: % global identity Algor. 1890 LYM284 H16 barley gb 157 SOLEXA IBE438857 3397 430 86.4 blastp 1891 LYM284 H17 brachypodium 09vl D V474685 3398 430 84.3 blastp 1892 LYM284 H18 brachypodium 09vl D V488161 3399 430 88.2 blastp 1893 LYM284 H3 fescue gbl61DT6744 46 3400 430 86.91 tblastn 1894 LYM284 H19 maize|gbl70|AI63725 6 3401 430 88.5 blastp 1895 LYM284 H20 maize|gbl70|AI86113 1 3402 430 84.3 blastp 1896 LYM284 H21 maize|gbl70|BM5012 76 3403 430 83.8 blastp 1897 LYM284 H22 rice gbl70 OS01G430 20 3404 430 81.4 blastp 1898 LYM284 H23 rice gbl70 OS01G465 70 3405 430 84.6 blastp 1899 LYM284 H24 sorghum| 09v 11SB03G 027960 3406 430 80.6 blastp 1900 LYM284 H25 sorghum| 09v 11SB03G 029790 3407 430 85.1 blastp 1901 LYM284 H26 sorghum 09v 1 SB09G 029130 3408 430 87.2 blastp 1902 LYM284 H27 sugarcane gbl57.3BQ 533889 3409 430 84.5 blastp 1903 LYM284 H12 switchgrass gb167 DN 151636 3410 430 81 blastp 1904 LYM284 H13 switchgrass gb 167 FE6 34580 3411 430 85.4 blastp 1905 LYM284 H14 switchgrass gb 167 FL7 12120 3412 430 89.53 tblastn 1906 LYM284 H15 wheat|gbl64|BE40078 9 3413 430 88.1 blastp 1907 LYM284 H16 wheat|gbl64|BF20080 4 3414 430 80.4 blastp 1908 LYM285 H3 brachypodium 09vl D V476342 3415 431 89.2 blastp 1909 LYM285 H4 maize|gbl70|AI37229 8 3416 431 88.1 blastp 1910 LYM285 H5 rice gbl70 OS01G699 00 3417 431 99.82 tblastn 1911 LYM285 H6 sorghum|09v 1 |SB03G 044210 3418 431 89.3 blastp 1912 LYM285 H3 switchgrass gb 167 DN 142770 3419 431 89.75 tblastn 1913 LYM288 H6 brachypodium 09vl D V471350 3420 433 83.3 blastp 1914 LYM288 HI leymus gbl66 EG3779 96 3421 433 84.7 blastp 1915 LYM288 H7 maize gbl 70 AI97792 4 3422 433 84.5 blastp 1916 LYM288 H8 sorghum|09vl|SB02G 039240 3423 433 83.9 blastp 2016213786 11 Aug 2016 118 Nucl. SEQ ID NO: Gene Name cluster name Polyp. SEQ ID NO: Homolog. to SEQ ID NO: % global identity Algor. 1917 LYM288 H9 sugarcane gbl57.3 CA 067537 3424 433 85.8 blastp 1918 LYM288 H5 switchgrass gb167 DN 151710 3425 433 85.3 blastp 1919 LYM288 H6 switchgrass gbl 67 FE6 10990 3426 433 85.3 blastp 1920 LYM289 H39 barley gb 157 SOLEXA IAL500321 3427 434 91.1 blastp 1921 LYM289 H40 barley gb 157 SOLEXA |AV915627 3428 434 92.7 blastp 1922 LYM289 H41 barley gb 157 SOLEXA IBF624195 3429 434 98.2 blastp 1923 LYM289 H42 barley gb 157 SOLEXA IBF627133 3430 434 92.7 blastp 1924 LYM289 H43 barley gb 157 SOLEXA IBQ739963 3431 434 92.7 blastp 1925 LYM289 H44 brachypodium 09vl G FXEF059989X41 3432 434 81.8 blastp 1926 LYM289 H7 cacao|gbl67|CU56893 3 3433 434 85.5 blastp 1927 LYM289 H8 fescue gb 161 CK8015 01 3434 434 90.9 blastp 1928 LYM289 H9 fescue gbl61DT6836 63 3435 434 90.9 blastp 1929 LYM289 H10 leymus gb 16 6 EG3 762 87 3436 434 96.4 blastp 1930 LYM289 H45 lolium|09vl|AU24668 3 3437 434 89.1 blastp 1931 LYM289 HI 1 lovegrass gbl67DN48 0351 3438 434 87.3 blastp 1932 LYM289 H46 maize|gbl70|AI63724 2 3439 434 81.8 blastp 1933 LYM289 H47 maize | gb 17 01LLEC 8 6 5320 3440 434 81.8 blastp 1934 LYM289 H48 maize|gbl70|T12715 3441 434 87.3 blastp 1935 LYM289 H49 millet 09vlCD724594 3442 434 80 blastp 1936 LYM289 H50 millet 09v 1 EB410971 3443 434 87.3 blastp 1937 LYM289 H15 oat|gbl64|CN818354 3444 434 90.9 blastp 1938 LYM289 H16 pine apple gb 15 7.2 DT 337702 3445 434 80 blastp 1939 LYM289 H51 rice gbl70 OS06G051 20 3446 434 83.6 blastp 1940 LYM289 H52 sorghum 09v 1 SB09G 005410 3447 434 80 blastp 1941 LYM289 H53 sorghum 09v 1 SB 10G 002980 3448 434 87.3 blastp 1942 LYM289 H54 sugarcane gbl57.3 CA 117495 3449 434 87.3 blastp 1943 LYM289 H55 sugarcane gbl57.3 CA 149658 3450 434 81.8 blastp 2016213786 11 Aug 2016 119 Nucl. SEQ ID NO: Gene Name cluster name Polyp. SEQ ID NO: Homolog. to SEQ ID NO: % global identity Algor. 1944 LYM289 H56 sugarcane gbl57.3 CF 575668 3451 434 87.3 blastp 1945 LYM289 H23 switchgrass gb167 DN 144776 3452 434 80 blastp 1946 LYM289 H24 switchgrass gb167 DN 144989 3453 434 89.1 blastp 1947 LYM289 H25 switchgrass gb 167 FE6 07508 3454 434 89.1 blastp 1948 LYM289 H26 switchgrass gb 167 FL7 36037 3455 434 81.8 blastp 1949 LYM289 H27 wheat|gbl64|AL81 111 9 3456 434 98.2 blastp 1950 LYM289 H28 wheat|gbl64|BE44378 6 3457 434 96.4 blastp 1951 LYM289 H29 wheat gbl 64 BG90709 8 3458 434 98.2 blastp 1952 LYM289 H30 wheat|gb 164|BM 13 65 71 3459 434 96.4 blastp 1953 LYM289 H31 wheat|gbl64|BQ80426 1 3460 434 96.4 blastp 1954 LYM289 H32 wheat|gbl64|CA61658 6 3461 434 81.8 blastp 1955 LYM289 H33 wheat|gb 164|CA64017 8 3462 434 98.2 blastp 1956 LYM289 H34 wheat|gbl64|CA64378 4 3463 434 98.2 blastp 1957 LYM289 H35 wheat gbl 64 CA73397 2 3464 434 80.36 tblastn 1958 LYM289 H36 wheat gbl 64 CD89687 3 3465 434 82.1 blastp 1959 LYM289 H37 wheat|gbl64|CJ58670 9 3466 434 89.1 blastp 1960 LYM289 H38 wheat gbl 64 CJ64697 0 3467 434 80 blastp 1961 LYM289 H39 wheatgbl64 CJ90337 8 3468 434 96.4 blastp 1962 LYM290 H10 barley gb 157 SOLEXA IBE412989 3469 435 82.9 blastp 1963 LYM290 HI 1 brachypodium 09vl G T759831 3470 435 81.9 blastp 1964 LYM290 H12 rice gbl70 OS04G202 30 3471 435 82.9 blastp 1965 LYM290 H3 rye|gbl64|BE495099 3472 435 81.9 blastp 1966 LYM290 H13 sorghum 09v 1 SBO1G 009390 3473 435 95.2 blastp 1967 LYM290 H14 sorghum 09v 1 SB06G 004500 3474 435 94.8 blastp 1968 LYM290 H15 sugarcane gbl57.3 BQ 535968 3475 435 95.7 blastp 1969 LYM290 H16 sugarcane gbl57.3 CA 136629 3476 435 80.3 blastp 1970 LYM290 H8 switchgrass gbl67 FE6 22978 3477 435 91.4 blastp 120

Nucl. SEQ ID NO: Gene Name cluster name Polyp. SEQ ID NO: Homolog. to SEQ ID NO: % global identity Algor. 1971 LYM290 H9 wheat gbl 64 BE43009 0 3478 435 83.3 blastp 1972 LYM290 H10 wheat|gbl64|BF 19952 4 3479 435 82.4 blastp 1973 LYM293 HO rice|gbl70|OS09G385 10 3480 437 91.8 blastp

Table 2: Provided are the homologous polypeptides and polynucleotides of the genes for increasing yield (e.g., oil yield, seed yield, fiber yield and/or quality), growth rate, vigor, biomass, abiotic stress tolerance, nitrogen use efficiency, water use efficiency and fertilizer use efficiency genes of a plant which are listed in Table 1 above. Homology was calculated as % of identity over the aligned sequences. The query sequences were polynucleotide sequences SEQ ID NOs: 1-239 and polypeptide SEQ ID NOs:240-465 and the subject sequences are protein sequences identified in the database based on greater than 80 % identity to the predicted translated sequences of the query nucleotide sequences or to the polypeptide sequences. "Nucl." = polynucleotide; "polyp." = polypeptide; "Algor." = algorithm (used for sequence alignment and determination of percent homology).

The following sequences were found to be 100 % identical: SEQ ID NO: 4 is identical to SEQ ID NO: 478; SEQ ID NO: 24 is identical to SEQ ID NO: 914; SEQ ID NO: 79 is identical to SEQ ID NO: 1050; SEQ ID NO: 132 is identical to SEQ ID NO: 3608; SEQ ID NO: 163 is identical to SEQ ID NO: 1734; SEQ ID NO: 249 is identical to SEQ ID NO: 2100, 2101, 2103, and 2108; SEQ ID NO: 321 is identical to SEQ ID NO: 2771; SEQ ID NO: 382 is identical to SEQ ID NO: 3019; SEQ ID NO: 387 is identical to SEQ ID NO: 2945; SEQ ID N0426 is identical to SEQ ID NO: 3387; SEQ ID NO: 446 is identical to SEQ ID NO: 2946; SEQ ID NO: 449 is identical to SEQ ID NO: 3705; SEQ ID NO: 2005 is identical to SEQ ID NO: 2011 and 2012; SEQ ID NO: 2007 is identical to SEQ ID NO: 2043 and 2045; SEQ ID NO: 2038 is identical to SEQ ID NO: 2039; SEQ ID NO: 2071 is identical to SEQ ID NO: 2072; SEQ ID NO: 2075 is identical to SEQ ID NO:2076, 2078, 2079, 2083, 2084, 2086, 2089, 2090, 2092, 2093, 2095, 2120, 2122, 2235, 2236, 2238, 2239, 2277, and 2278; SEQ ID NO: 2080 is identical to SEQ ID NO: 2155, 2176, 2179, 2248, and 2268; SEQ ID NO: 2102 is identical to SEQ ID NO: 2193; SEQ ID NO: 2105 is identical to SEQ ID NO: 2147, 2181, 2196, 2197, 2210, 2211, 2213, 2254, and 2256; SEQ ID NO: 2125 is identical to SEQ ID NO: 2126 and 2127; SEQ ID NO: 2130 is identical to SEQ ID NO: 2131, 2214, 2228, 2231, and 2251; SEQ ID NO: 2134 is identical to SEQ ID NO: 2247; SEQ ID NO: 2144 is identical to SEQ ID NO: 2153 and 2201; SEQ ID NO: 2188 is identical to 2016213786 11 Aug 2016 121 SEQ ID NO: 2191, 2253, 2264, and 2271; SEQ ID NO: 2189 is identical to SEQ ID NO: 2202, 2252, 2265, 2266, 2270, and 2272; SEQ ID NO: 2215 is identical to SEQ ID NO: 2250 and 2284; SEQ ID NO: 2218 is identical to SEQ ID NO: 2219; SEQ ID NO: 2220 is identical to SEQ ID NO: 2221 and 2258; SEQ ID NO: 2356 is identical to SEQ 5 ID NO: 2357 and 2359; SEQ ID NO: 2380 is identical to SEQ ID NO: 2402; SEQ ID NO: 2384 is identical to SEQ ID NO: 2387; SEQ ID NO: 2463 is identical to SEQ ID NO:2464; SEQ ID NO: 2481 is identical to SEQ ID NO: 2483; SEQ ID NO: 2485 is identical to SEQ ID NO: 2486; SEQ ID NO: 2533 is identical to SEQ ID NO: 2538; SEQ ID NO: 2582 is identical to SEQ ID NO: 2583; SEQ ID NO: 2588 is identical to 10 SEQ ID NO: 2594, 2603, 2621, and 2629; SEQ ID NO: 2589 is identical to SEQ ID NO:2590, 2591, 2592, 2595, 2596, 2601, 2604, 2605, 2623, 2624, 2626, 2627, 2630, 2756, 2757, 2758, 2760, 2761, 2762, 2764, 2765, and 2807; SEQ ID NO:2593 is identical to SEQ ID NO:2632, and 2767; SEQ ID NO: 2600 is identical to SEQ ID NO: 2622; SEQ ID NO: 2606 is identical to SEQ ID NO: 2610; SEQ ID NO: 2607 is 15 identical to SEQ ID NO: 2609; SEQ ID NO: 2625 is identical to SEQ ID NO: 2713; SEQ ID NO: 2638 is identical to SEQ ID NO: 2639; SEQ ID NO: 2644 is identical to SEQ ID NO: 2727; SEQ ID NO: 2645 is identical to SEQ ID NO: 2726; SEQ ID NO: 2665 is identical to SEQ ID NO: 2719; SEQ ID NO: 2687 is identical to SEQ ID NO: 2689; SEQ ID NO: 2691 is identical to SEQ ID NO: 2693 and 2698; SEQ ID NO: 2694 20 is identical to SEQ ID NO: 2697; SEQ ID NO: 2712 is identical to SEQ ID NO: 2816, 2817 and 2818; SEQ ID NO: 2748 is identical to SEQ ID NO: 2749, 2778 and 2815; SEQ ID NO: 2750 is identical to SEQ ID NO: 2751 and 2776; SEQ ID NO: 2779 is identical to SEQ ID NO: 2790 and 2794; SEQ ID NO: 2801 is identical to SEQ ID NO: 2804; SEQ ID NO: 2873 is identical to SEQ ID NO: 2880; SEQ ID NO: 2876 is 25 identical to SEQ ID NO: 2881; SEQ ID NO: 2877 is identical to SEQ ID NO: 2879;

SEQ ID NO: 2908 is identical to SEQ ID NO: 2909; SEQ ID NO: 3135 is identical to SEQ ID NO: 3136; SEQ ID NO: 3138 is identical to SEQ ID NO: 3145; SEQ ID NO: 3268 is identical to SEQ ID NO: 3271, 3272, 3278, 3326, and 3327; SEQ ID NO: 3274 is identical to SEQ ID NO: 3351, 3352, and 3353; SEQ ID NO: 3277 is identical to 30 SEQ ID NO: 3296; SEQ ID NO: 3285 is identical to SEQ ID NO: 3313; SEQ ID NO: 3287 is identical to SEQ ID NO: 3302; SEQ ID NO: 3309 is identical to SEQ ID NO: 3333, 3337, 3338, and 3342; SEQ ID NO: 3318 is identical to SEQ ID NO: 3319; SEQ 2016213786 11 Aug 2016 122 ID NO: 3322 is identical to SEQ ID NO: 3331; SEQ ID NO: 3428 is identical to SEQ ID NO: 3430 3431; SEQ ID NO: 3434 is identical to SEQ ID NO: 3435; SEQ ID NO: 3439 is identical to SEQ ID NO: 3440 and 3461; SEQ ID NO: 3448 is identical to SEQ ID NO: 3449 and 3451; SEQ ID NO: 3453 is identical to SEQ ID NO: 3454; SEQ ID 5 NO: 3456 is identical to SEQ ID NO: 3458, 3462 and 3463; SEQ ID NO: 3457 is identical to SEQ ID NO: 3459 and 3468;

The output of the functional genomics approach described herein is a set of genes highly predicted to improve yield and/or other agronomic important traits such as growth rate, vigor, oil content, fiber yield and/or quality, biomass, growth rate, abiotic 10 stress tolerance, nitrogen use efficiency, water use efficiency and fertilizer use efficiency of a plant by increasing their expression. Although each gene is predicted to have its own impact, modifying the mode of expression of more than one gene is expected to provide an additive or synergistic effect on the plant yield and/or other agronomic important yields performance. Altering the expression of each gene 15 described here alone or set of genes together increases the overall yield and/or other agronomic important traits, hence expects to increase agricultural productivity. EXAMPLE 3

PRODUCTION OF BARLEY TRANSCRIPTOM AND HIGH THROUGHPUT 20 CORRELATION ANALYSIS USING 44K BARLEY OLIGONUCLEOTIDE MICROARRAY

In order to produce a high throughput correlation analysis, the present inventors utilized a Barley oligonucleotide micro-array, produced by Agilent Technologies [Hypertext Transfer Protocol ://World Wide Web (dot) chem. (dot) agilent (dot) 25 com/Scripts/PDS (dot) asp?lPage=50879]. The array oligonucleotide represents about 47,500 Barley genes and transcripts. In order to define correlations between the levels of RNA expression and yield or vigor related parameters, various plant characteristics of 25 different Barley accessions were analyzed. Among them, 13 accessions encompassing the observed variance were selected for RNA expression analysis. The 30 correlation between the RNA levels and the characterized parameters was analyzed using Pearson correlation test [Hypertext Transfer Protocol ://World Wide Web (dot) davidmlane (dot) com/hyperstat/A34739 (dot) html]. 2016213786 11 Aug 2016 123

Experimental procedures RNA extraction - Five tissues at different developmental stages [meristem, flower, booting spike, stem, flag leaf], representing different plant characteristics, were sampled and RNA was extracted using TRIzol Reagent from Invitrogen [Hypertext 5 Transfer Protocol ://World Wide Web (dot) invitrogen (dot) com/content (dot)cfm?pageid=469]. Approximately 30-50 mg of tissue was taken from samples. The weighed tissues were ground using pestle and mortar in liquid nitrogen and resuspended in 500 μΐ of TRIzol Reagent. To the homogenized lysate, 100 μΐ of chloroform was added followed by precipitation using isopropanol and two washes with 10 75 % ethanol. The RNA was eluted in 30 μΐ of RNase-free water. RNA samples were cleaned up using Qiagen’s RNeasy minikit clean-up protocol as per the manufacturer’s protocol (QIAGEN Inc, CA USA).

For convenience, each micro-array expression information tissue type has received a Set ID as summarized in Table 3 below. 15

Table 3

Barley transcriptom expression sets

Expression Set Set ID Meristem A Flower B Booting spike C Stem D Flag leaf E

Table 3 20

Barley yield components and vigor related parameters assessment - 25 Barley accessions in 4 repetitive blocks (named A, B, C, and D), each containing 4 plants per plot were grown at net house. Plants were phenotyped on a daily basis following the standard descriptor of barley (Table 4, below). Harvest was conducted while 50 % of 25 the spikes were dry to avoid spontaneous release of the seeds. Plants were separated to the vegetative part and spikes, of them, 5 spikes were threshed (grains were separated from the glumes) for additional grain analysis such as size measurement, grain count per spike and grain yield per spike. All material was oven dried and the seeds were threshed manually from the spikes prior to measurement of the seed characteristics 30 (weight and size) using scanning and image analysis. The image analysis system 2016213786 11 Aug 2016 124 included a personal desktop computer (Intel P4 3.0 GHz processor) and a public domain program - ImageJ 1.37 (Java based image processing program, which was developed at the U.S. National Institutes of Health and freely available on the internet [Hypertext Transfer Protocol://rsbweb (dot) nih (dot) gov/]. Next, analyzed data was saved to text 5 files and processed using the JMP statistical analysis software (SAS institute).

Table 4

Barley standard descriptors

Trait Parameter Range Description Growth habit Scoring 1-9 Prostrate (1) or Erect (9) Hairiness of basal leaves Scoring P (Presence)/A (Absence) Absence (1) or Presence (2) Stem pigmentation Scoring 1-5 Green (1), Basal only or Half or more (5) Days to Flowering Days Days from sowing to emergence of awns Plant height Centimeter (cm) Height from ground level to top of the longest spike excluding awns Spikes per plant Number Terminal Counting Spike length Centimeter (cm) Terminal Counting 5 spikes per plant Grains per spike Number Terminal Counting 5 spikes per plant Vegetative dry weight Gram Oven-dried for 48 hours at 70°C Spikes dry weight Gram Oven-dried for 48 hours at 30°C 10 Table 4.

Grains per spike - At the end of the experiment (50 % of the spikes were dry) all spikes from plots within blocks A-D are collected. The total number of grains from 5 spikes that were manually threshed was counted. The average grain per spike is 15 calculated by dividing the total grain number by the number of spikes.

Grain average size (cm) - At the end of the experiment (50 % of the spikes were dry) all spikes from plots within blocks A-D are collected. The total grains from 5 spikes that were manually threshed were scanned and images were analyzed using the digital imaging system. Grain scanning was done using Brother scanner (model DCP-20 135), at the 200 dpi resolution and analyzed with Image J software. The average grain size was calculated by dividing the total grain size by the total grain number.

Grain average weight (mgr) - At the end of the experiment (50 % of the spikes were dry) all spikes from plots within blocks A-D are collected. The total grains from 5 spikes that were manually threshed were counted and weight. The average weight was 25 calculated by dividing the total weight by the total grain number. 2016213786 11 Aug 2016 125

Grain yield per spike (gr) - At the end of the experiment (50 % of the spikes were dry) all spikes from plots within blocks A-D are collected. The total grains from 5 spikes that were manually threshed were weight. The grain yield was calculated by dividing the total weight by the spike number. 5 Spike length analysis - At the end of the experiment (50 % of the spikes were dry) all spikes from plots within blocks A-D are collected. The five chosen spikes per plant were measured using measuring tape excluding the awns.

Spike number analysis - At the end of the experiment (50 % of the spikes were dry) all spikes from plots within blocks A-D are collected. The spikes per plant were 10 counted.

Growth habit scoring - At the growth stage 10 (booting), each of the plants was scored for its growth habit nature. The scale that was used was 1 for prostate nature till 9 for erect.

Hairiness of basal leaves - At the growth stage 5 (leaf sheath strongly erect; end 15 of tillering), each of the plants was scored for its hairiness nature of the leaf before the last. The scale that was used was 1 for prostate nature till 9 for erect.

Plant height - At the harvest stage (50 % of spikes were dry) each of the plants was measured for its height using measuring tape. Height was measured from ground level to top of the longest spike excluding awns. 20 Days to flowering - Each of the plants was monitored for flowering date. Days of flowering was calculated from sowing date till flowering date.

Stem pigmentation - At the growth stage 10 (booting), each of the plants was scored for its stem color. The scale that was used was 1 for green till 5 for full purple.

Vegetative dry weight and spike yield - At the end of the experiment (50 % of 25 the spikes were dry) all spikes and vegetative material from plots within blocks A-D are collected. The biomass and spikes weight of each plot was separated, measured and divided by the number of plants.

Dry weight = total weight of the vegetative portion above ground (excluding roots) after drying at 70 °C in oven for 48 hours; 30 Spike yield per plant = total spike weight per plant (gr) after drying at 30 °C in oven for 48 hours.

Harvest Index (for barley) - The harvest index is calculated using Formula VI. 2016213786 11 Aug 2016 126

Formula VI: Harvest Index = Average spike dry weight per plant/ (Average vegetative dry weight per plant + Average spike dry weight per plant)

Table 5 5 Barley correlated parameters (vectors)

Correlated parameter with (units) Correlation Id Grains per spike (numbers) 1 Grains size (mm2) 2 Grain weight (miligrams) 3 Grain Yield per spike (gr/spike) 4 Spike length (cm) 5 Spikes per plant (numbers) 6 Growth habit (scores 1-9) 7 Hairiness of basal leaves (scoring 1-2) 8 Plant height (cm) 9 Days to flowering (days) 10 Stem pigmentation (scoring 1-5) 11 Vegetative dry weight (gram) 12 Harvest Index (ratio) 13

Table 5.

Experimental Results 10 13 different Barley accessions were grown and characterized for 13 parameters as described above. The average for each of the measured parameter was calculated using the JMP software and values are summarized in Tables 6 and 7 below. Subsequent correlation analysis between the various transcriptom sets (Table 3) and the average parameters, was conducted. Follow, results were integrated to the database. 15

Table 6

Measured parameters of correlation Ids in Barley accessions

Accession /Parameter 6 10 3 5 2 1 7 Amatzya 48.85 62.40 35.05 12.04 0.27 20.23 2.60 Ashqelon 48.27 64.08 28.06 10.93 0.23 17.98 2.00 Canada park 37.42 65.15 28.76 11.83 0.24 17.27 1.92 Havarim stream 61.92 58.92 17.87 9.90 0.17 17.73 3.17 Jordan est 33.27 63.00 41.22 11.68 0.29 14.47 4.33 Klil 41.69 70.54 29.73 11.53 0.28 16.78 2.69 Maale Efraim ND 52.80 25.22 8.86 0.22 13.47 3.60 Mt Arbel 40.63 60.88 34.99 11.22 0.28 14.07 3.50 Mt Harif 62.00 58.10 20.58 11.11 0.19 21.54 3.00 Neomi 49.33 53.00 27.50 8.58 0.22 12.10 3.67 Neot Kdumim 50.60 60.40 37.13 10.18 0.27 14.36 2.47 127

Accession /Parameter 6 10 3 5 2 1 7 Oren canyon 43.09 64.58 29.56 10.51 0.27 15.28 3.50 Yeruham 51.40 56.00 19.58 9.80 0.18 17.07 3.00

Table 6. Provided are the values of each of the parameters measured in Barley accessions according to the following correlation identifications (Correlation Ids): 6 = Spikes per plant; 10 = Days to flowering; 3 = Grain weight; 5 = Spike length; 2 = Grains Size; 1 = Grains per spike; 7 = Growth habit.

Table 7

Barley accessions, additional measured parameters

Accession /Parameter 8 9 4 11 12 13 Amatzya 1.53 134.27 3.56 1.13 78.87 0.45 Ashqelon 1.33 130.50 2.54 2.50 66.14 0.42 Canada park 1.69 138.77 2.58 1.69 68.49 0.40 Havarim stream 1.08 114.58 1.57 1.75 53.39 0.44 Jordan est 1.42 127.75 3.03 2.33 68.30 0.43 Klil 1.69 129.38 2.52 2.31 74.17 0.40 Maale Efraim 1.30 103.89 1.55 1.70 35.35 0.52 Mt Arbel 1.19 121.63 2.62 2.19 58.33 0.48 Mt Harif 1.00 126.80 2.30 2.30 62.23 0.44 Neomi 1.17 99.83 1.68 1.83 38.32 0.49 Neot Kdumim 1.60 121.40 2.68 3.07 68.31 0.45 Oren canyon 1.08 118.42 2.35 1.58 56.15 ND Yeruham 1.17 117.17 1.67 2.17 42.68 ND 2016213786 11 Aug 2016 10 Table 7. Provided are the values of each of the parameters measured in Barley accessions according to the following correlation identifications (Correlation Ids): 8 = Hairiness of basal leaves; 9 = Plant height; 4 = Grain yield per spike; 11 = Stem pigmentation; 12 = Vegetative dry weight; 13 = Harvest Index. 15

Table 8

Correlation between the expression level of the selected polynucleotides of the invention and their homologues in specific tissues or developmental stages and the phenotypic performance across Barley ecotypes

Gene Name Expression Set Correlation Vector R P LYM26 A 12 0.87938 0.00178 LYM26 A 4 0.86421 0.00265 LYM26 A 12 0.85977 0.00069 LYM26 A 4 0.84991 0.00092 LYM26 A 9 0.83315 0.00145 LYM26 A 9 0.81930 0.00689 LYM26 A 5 0.81231 0.00238 LYM26 A 5 0.80624 0.00867 LYM26 C 1 0.74897 0.00799 LYM26 C 1 0.73316 0.02461 2016213786 11 Aug 2016 128 Gene Name Expression Set Correlation Vector R P LYM26 A 10 0.72560 0.02691 LYM51 A 10 0.93629 0.00020 LYM51 A 12 0.92036 0.00043 LYM51 A 5 0.88679 0.00144 LYM51 A 9 0.87500 0.00201 LYM51 A 10 0.85681 0.00075 LYM51 A 4 0.82050 0.00674 LYM51 A 5 0.78204 0.00445 LYM51 A 9 0.77050 0.00552 LYM51 A 12 0.74603 0.00838 LYM51 A 4 0.71036 0.01430 LYM59 A 4 0.88939 0.00133 LYM59 A 3 0.80853 0.00834 LYM59 A 2 0.80307 0.00915 LYM59 A 12 0.79319 0.01075 LYM59 A 5 0.73433 0.02426 LYM59 A 10 0.72556 0.02693 LYM66 A 1 0.77697 0.01376 LYM66 A 1 0.75508 0.00722 LYM82 A 10 0.88760 0.00140 LYM82 A 12 0.86378 0.00061 LYM82 A 12 0.85529 0.00329 LYM82 A 10 0.84623 0.00102 LYM82 A 9 0.83000 0.00562 LYM82 A 9 0.82602 0.00173 LYM82 A 4 0.81534 0.00222 LYM82 A 4 0.79017 0.01127 LYM82 A 5 0.78467 0.00424 LYM82 A 5 0.76164 0.01709 LYM84 C 2 0.79418 0.01058 LYM84 B 2 0.79145 0.01928 LYM84 C 3 0.77694 0.01377 LYM84 B 3 0.75502 0.03033 LYM84 A 2 0.70823 0.01473 LYM99 C 7 0.75021 0.01989 LYM99 A 7 0.72294 0.02776 LYM95 B 2 0.81158 0.00436 LYM95 B 3 0.77615 0.00830 LYM95 B 10 0.73186 0.01612 LYM95 C 2 0.72471 0.02719 LYM95 B 5 0.71170 0.02097 LYM100 A 3 0.77258 0.01467 LYM100 A 4 0.76559 0.01619 LYM100 A 2 0.72628 0.02670 LYM105 A 4 0.80126 0.00943 LYM105 A 2 0.80060 0.00953 LYM105 A 3 0.78770 0.01171 LYM105 A 8 0.71795 0.02939 LYM105 B 1 0.71160 0.04775 LYM137 C 5 0.91789 0.00007 LYM137 C 4 0.87211 0.00046 LYM137 C 10 0.86290 0.00063 LYM137 C 12 0.85934 0.00070 2016213786 11 Aug 2016 129 Gene Name Expression Set Correlation Vector R P LYM137 C 9 0.82372 0.00183 LYM137 C 3 0.73788 0.02323 LYM137 c 2 0.71562 0.03017 LYM140 c 6 0.83623 0.00968 LYM142 B 6 0.85850 0.01338 LYM142 A 4 0.80126 0.00943 LYM142 A 2 0.80060 0.00953 LYM142 A 3 0.78770 0.01171 LYM142 A 8 0.73208 0.01042 LYM142 A 8 0.71795 0.02939 LYM142 B 1 0.71160 0.04775 LYM148 A 4 0.79887 0.00318 LYM148 A 12 0.76743 0.00583 LYM148 A 4 0.76342 0.01668 LYM148 A 9 0.74349 0.00873 LYM148 A 5 0.70612 0.01516 LYM149 B 7 0.75092 0.03177 LYM156 C 2 0.79406 0.00352 LYM156 C 2 0.77724 0.01371 LYM156 A 2 0.76712 0.00586 LYM156 A 3 0.73707 0.00965 LYM156 C 3 0.71152 0.01407 LYM156 B 3 0.70014 0.05315 LYM157 A 4 0.78681 0.01187 LYM157 A 3 0.73234 0.02485 LYM157 A 12 0.72729 0.02639 LYM160 A 12 0.87825 0.00184 LYM160 A 10 0.82699 0.00596 LYM160 A 12 0.82567 0.00174 LYM160 A 9 0.80855 0.00834 LYM160 A 9 0.80222 0.00297 LYM160 A 10 0.74770 0.00815 LYM160 A 5 0.72266 0.02785 LYM160 A 5 0.71752 0.01292 LYM154 C 2 0.92810 0.00004 LYM154 C 3 0.90313 0.00014 LYM154 c 4 0.85169 0.00088 LYM154 c 5 0.73538 0.00991 LYM154 c 10 0.71818 0.01280 LYM154 c 12 0.70985 0.01440 LYM155 c 6 0.72312 0.04266 LYM155 c 1 0.70598 0.01519 LYM180 c 1 0.76320 0.00628 LYM180 B 6 0.75133 0.05153 LYM181 C 6 0.78450 0.02115 LYM184 B 6 0.82395 0.02266 LYM184 B 6 0.73704 0.01501 LYM189 A 10 0.81585 0.00733 LYM189 A 12 0.81256 0.00777 LYM189 A 9 0.72388 0.02746 LYM189 A 5 0.71589 0.03008 LYM192 A 2 0.86386 0.00061 LYM192 A 3 0.80919 0.00255 2016213786 11 Aug 2016 130 Gene Name Expression Set Correlation Vector R P LYM192 A 3 0.77612 0.01393 LYM278 A 4 0.90217 0.00088 LYM278 A 4 0.87108 0.00048 LYM278 A 12 0.81518 0.00742 LYM278 A 3 0.79925 0.00975 LYM278 A 3 0.78102 0.00454 LYM278 A 12 0.76569 0.00601 LYM278 A 2 0.73983 0.00925 LYM38 A 4 0.97624 0.00001 LYM38 A 12 0.82191 0.00191 LYM38 A 8 0.82190 0.00656 LYM38 A 3 0.82153 0.00193 LYM38 A 5 0.81079 0.00246 LYM52 B 8 0.88462 0.00352 LYM52 A 2 0.80812 0.00261 LYM52 A 4 0.80802 0.00841 LYM52 A 3 0.78340 0.01251 LYM52 A 12 0.77364 0.01444 LYM52 A 9 0.75221 0.01938 LYM52 A 5 0.74914 0.02016 LYM52 A 8 0.71086 0.03181 LYM56 A 3 0.85797 0.00073 LYM56 A 4 0.85130 0.00089 LYM56 A 2 0.82071 0.00196 LYM56 A 8 0.76236 0.01692 LYM56 A 12 0.72510 0.01157 LYM83 A 9 0.87556 0.00198 LYM83 A 5 0.87005 0.00050 LYM83 A 12 0.82187 0.00191 LYM90 C 4 0.86848 0.00238 LYM90 C 3 0.81261 0.00777 LYM90 c 12 0.77921 0.01332 LYM90 c 2 0.76512 0.01629 LYM93 A 9 0.86630 0.00056 LYM93 A 12 0.78696 0.00405 LYM93 A 5 0.76542 0.00604 LYM106 A 3 0.79483 0.01047 LYM106 A 2 0.75674 0.01825 LYM106 C 6 0.73962 0.03596 LYM159 c 1 0.82807 0.00584 LYM159 B 8 0.79356 0.01873 LYM161 C 3 0.89287 0.00119 LYM161 C 2 0.88206 0.00165 LYM161 A 6 0.85373 0.00699 LYM161 C 4 0.74623 0.02093 LYM178 C 6 0.83756 0.00945 LYM182 A 6 0.93567 0.00063 LYM185 C 4 0.76455 0.01642 LYM185 A 1 0.75952 0.01759 LYM185 A 6 0.70292 0.01584 LYM186 A 6 0.86003 0.00616 LYM188 A 6 0.82774 0.00166 LYM188 C 2 0.73602 0.02377 131

Gene Name Expression Set Correlation Vector R P LYM188 C 3 0.71072 0.03186 LYM194 A 2 0.89053 0.00024 LYM194 A 3 0.82982 0.00157 LYM289 A 9 0.77609 0.01394 LYM289 A 5 0.77182 0.01483

Table 8. Provided are the correlations (R) and p-values (P) between the expression levels of selected genes of some embodiments of the invention in various tissues or developmental stages (Expression sets) and the phenotypic performance in various yield (seed yield, oil yield, oil content), biomass, growth rate and/or vigor 5 components [Correlation (Corr.) vector (Vec.)] Corr. Vec. = correlation vector specified in Tables 5, 6 and 7; Exp. Set = expression set specified in Table 3. 2016213786 11 Aug 2016 EXAMPLE 4

PRODUCTION OF ARABIDOPSIS TRANSCRIPTOM AND HIGH 10 THROUGHPUT CORRELATION ANALYSIS OF YIELD, BIOMASS AND/OR

VIGOR RELATED PARAMETERS USING 44K ARABIDOPSIS FULL GENOME OLIGONUCLEOTIDE MICRO-ARRAY

To produce a high throughput correlation analysis, the present inventors utilized an Arabidopsis thaliana oligonucleotide micro-array, produced by Agilent Technologies 15 [Hypertext Transfer Protocol ://World Wide Web (dot) chem. (dot) agilent (dot) com/Scripts/PDS (dot) asp?lPage=50879]. The array oligonucleotide represents about 40,000 A. thaliana genes and transcripts designed based on data from the TIGR ATH1 v.5 database and Arabidopsis MPSS (University of Delaware) databases. To define correlations between the levels of RNA expression and yield, biomass components or 20 vigor related parameters, various plant characteristics of 15 different Arabidopsis ecotypes were analyzed. Among them, nine ecotypes encompassing the observed variance were selected for RNA expression analysis. The correlation between the RNA levels and the characterized parameters was analyzed using Pearson correlation test [Hypertext Transfer Protocol ://World Wide Web (dot) davidmlane (dot) 25 com/hyperstat/A34739 (dot) html].

Experimental procedures RNA extraction - Five tissues at different developmental stages including root, leaf, flower at anthesis, seed at 5 days after flowering (DAF) and seed at 12 DAF, representing different plant characteristics, were sampled and RNA was extracted as 2016213786 11 Aug 2016 132 described in Example 3 above. For convenience, each micro-array expression information tissue type has received a Set ID as summarized in Table 9 below.

Table 9 5 Tissues used for Arabidopsis transcriptom expression sets

Expression Set Set ID Root A Leaf B Flower C Seed 5 DAF D Seed 12 DAF E

Table 9: Provided are the identification (ID) letters of each of the Arabidopsis expression sets (A-E). DAF = days after flowering. 10

Yield components and vigor related parameters assessment - eight out of the nine Arabidopsis ecotypes were used in each of 5 repetitive blocks (named A, B, C, D and E), each containing 20 plants per plot. The plants were grown in a greenhouse at controlled conditions in 22 °C, and the N:P:K fertilizer (20:20:20; weight ratios) 15 [nitrogen (N), phosphorus (P) and potassium (K)] was added. During this time data was collected, documented and analyzed. Additional data was collected through the seedling stage of plants grown in a tissue culture in vertical grown transparent agar plates. Most of chosen parameters were analyzed by digital imaging.

Digital imaging in Tissue culture - A laboratory image acquisition system 20 was used for capturing images of plantlets sawn in square agar plates. The image acquisition system consists of a digital reflex camera (Canon EOS 300D) attached to a 55 mm focal length lens (Canon EF-S series), mounted on a reproduction device (Kaiser RS), which included 4 light units (4x150 Watts light bulb) and located in a darkroom.

Digital imaging in Greenhouse - The image capturing process was repeated 25 every 3-4 days starting at day 7 till day 30. The same camera attached to a 24 mm focal length lens (Canon EF series), placed in a custom made iron mount, was used for capturing images of larger plants sawn in white tubs in an environmental controlled greenhouse. The white tubs were square shape with measurements of 36 x 26.2 cm and 7.5 cm deep. During the capture process, the tubs were placed beneath the iron mount, 30 while avoiding direct sun light and casting of shadows. This process was repeated every 3-4 days for up to 30 days. 2016213786 11 Aug 2016 133

An image analysis system was used, which consists of a personal desktop computer (Intel P4 3.0 GHz processor) and a public domain program - ImageJ 1.37, Java based image processing program, which was developed at the U.S National Institutes of Health and 5 is freely available on the internet at Hypertext Transfer Protocol://rsbweb (dot) nih (dot) gov/. Images were captured in resolution of 6 Mega Pixels (3072 x 2048 pixels) and stored in a low compression JPEG (Joint Photographic Experts Group standard) format. Next, analyzed data was saved to text files and processed using the JMP statistical analysis software (SAS institute). 10 Leaf analysis - Using the digital analysis leaves data was calculated, including leaf number, area, perimeter, length and width. On day 30, 3-4 representative plants were chosen from each plot of blocks A, B and C. The plants were dissected, each leaf was separated and was introduced between two glass trays, a photo of each plant was taken and the various parameters (such as leaf total area, laminar length etc.) were 15 calculated from the images. The blade circularity was calculated as laminar width divided by laminar length.

Root analysis - During 17 days, the different ecotypes were grown in transparent agar plates. The plates were photographed every 3 days starting at day 7 in the photography room and the roots development was documented (see examples in Figures 20 3A-F). The growth rate of roots was calculated according to Formula VII.

Formula VII:

Relative growth rate of root coverage = Regression coefficient of root coverage along time course.

Vegetative growth rate analysis - was calculated according to Formula VIII. 25 The analysis was ended with the appearance of overlapping plants.

Formula VIII

Relative vegetative growth rate area = Regression coefficient of vegetative area along time course.

For comparison between ecotypes the calculated rate was normalized using plant 30 developmental stage as represented by the number of true leaves. In cases where plants with 8 leaves had been sampled twice (for example at day 10 and day 13), only the largest sample was chosen and added to the Anova comparison. 2016213786 11 Aug 2016 134

Seeds in siliques analysis - On day 70, 15-17 siliques were collected from each plot in blocks D and E. The chosen siliques were light brown color but still intact. The siliques were opened in the photography room and the seeds were scatter on a glass tray, a high resolution digital picture was taken for each plot. Using the images the 5 number of seeds per silique was determined.

Seeds average weight - At the end of the experiment all seeds from plots of blocks A-C were collected. An average weight of 0.02 grams was measured from each sample, the seeds were scattered on a glass tray and a picture was taken. Using the digital analysis, the number of seeds in each sample was calculated. 10 Oil percentage in seeds - At the end of the experiment all seeds from plots of blocks A-C were collected. Columbia seeds from 3 plots were mixed grounded and then mounted onto the extraction chamber. 210 ml of n-Hexane (Cat No. 080951 Biolab Ltd.) were used as the solvent. The extraction was performed for 30 hours at medium heat 50 °C. Once the extraction has ended the n-Hexane was evaporated using the 15 evaporator at 35 °C and vacuum conditions. The process was repeated twice. The information gained from the Soxhlet extractor (Soxhlet, F. Die gewichtsanalytische Bestimmung des Milchfettes, Polytechnisches J. (Dingler's) 1879, 232, 461) was used to create a calibration curve for the Low Resonance NMR. The content of oil of all seed samples was determined using the Low Resonance NMR (MARAN Ultra- Oxford 20 Instrument) and its MultiQuant sowftware package.

Silique length analysis - On day 50 from sowing, 30 siliques from different plants in each plot were sampled in block A. The chosen siliques were green-yellow in color and were collected from the bottom parts of a grown plant’s stem. A digital photograph was taken to determine silique's length.

25 Dry weight and seed yield - On day 80 from sowing, the plants from blocks A-C were harvested and left to dry at 30 °C in a drying chamber. The biomass and seed weight of each plot was separated, measured and divided by the number of plants. Dry weight = total weight of the vegetative portion above ground (excluding roots) after drying at 30 °C in a drying chamber; Seed yield per plant = total seed weight per plant 30 (gr).

Oil yield - The oil yield was calculated using Formula IX. 2016213786 11 Aug 2016 135

Formula IX:

Seed Oil yield = Seed yield per plant (gr) * Oil % in seed Harvest Index (seed) - The harvest index was calculated using Formula IV (described above): Harvest Index = Average seed yield per plant/ Average dry weight. 5 Experimental Results

Nine different Arabidopsis ecotypes were grown and characterized for 18 parameters (named as vectors).

Table 10 1 o Arabidopsis correlated parameters (vectors)

Correlated parameter with Correlation ID Root length day 13 (cm) 1 Root length day 7 (cm) 2 Relative root growth (cm /day) day 13 3 Fresh weight per plant (gr) at bolting stage 4 Dry matter per plant (gr) 5 Vegetative growth rate (cm2 / day) till 8 true leaves 6 Blade circularity 7 Lamina width (cm) 8 Lamina length (cm) 9 Total leaf area per plant (cm) 10 1000 Seed weight (gr) 11 Oil % per seed 12 Seeds per silique 13 Silique length (cm) 14 Seed yield per plant (gr) 15 Oil yield per plant (mg) 16 Harvest Index 17 Leaf width/length 18

Table 10. Provided are the Arabidopsis correlated parameters (correlation ID Nos. 1-18). Abbreviations: Cm = centimeter(s); gr = gram(s); mg = milligram(s). 15 The characterized values are summarized in Tables 11 and 12 below.

Table 11

Measured parameters in Arabidopsis ecotypes

Ecotype 15 16 12 11 5 17 10 13 14 An-1 0.34 118.63 34.42 0.0203 0.64 0.53 46.86 45.44 1.06 Col-0 0.44 138.73 31.19 0.0230 1.27 0.35 109.89 53.47 1.26 Ct-1 0.59 224.06 38.05 0.0252 1.05 0.56 58.36 58.47 1.31 Cvi (N8580) 0.42 116.26 27.76 0.0344 1.28 0.33 56.80 35.27 1.47 Gr-6 0.61 218.27 35.49 0.0202 1.69 0.37 114.66 48.56 1.24 Kondara 0.43 142.11 32.91 0.0263 1.34 0.32 110.82 37.00 1.09 Ler-1 0.36 114.15 31.56 0.0205 0.81 0.45 88.49 39.38 1.18 136

Ecotype 15 16 12 11 5 17 10 13 14 Mt-0 0.62 190.06 30.79 0.0226 1.21 0.51 121.79 40.53 1.18 Shakdara 0.55 187.62 34.02 0.0235 1.35 0.41 93.04 25.53 1.00

Table 11. Provided are the values of each of the parameters measured in Arabidopsis ecotypes: 15 = Seed yield per plant (gram); 16 = oil yield per plant (mg); 12 = oil % per seed; 11 = 1000 seed weight (gr); 5 = dry matter per plant (gr); 17 = harvest index; 10 = total leaf area per plant (cm); 13 = seeds per silique; 14 = Silique length (cm). 2016213786 11 Aug 2016 5

Table 12

Additional measured parameters in Arabidopsis ecotypes

Ecotype 6 3 2 1 4 9 8 18 7 An-1 0.313 0.631 0.937 4.419 1.510 2.767 1.385 0.353 0.509 Col-0 0.378 0.664 1.759 8.530 3.607 3.544 1.697 0.288 0.481 Ct-1 0.484 1.176 0.701 5.621 1.935 3.274 1.460 0.316 0.450 Cvi (N8580) 0.474 1.089 0.728 4.834 2.082 3.785 1.374 0.258 0.370 Gr-6 0.425 0.907 0.991 5.957 3.556 3.690 1.828 0.356 0.501 Kondara 0.645 0.774 1.163 6.372 4.338 4.597 1.650 0.273 0.376 Ler-1 0.430 0.606 1.284 5.649 3.467 3.877 1.510 0.305 0.394 Mt-0 0.384 0.701 1.414 7.060 3.479 3.717 1.817 0.335 0.491 Shakdar a 0.471 0.782 1.251 7.041 3.710 4.149 1.668 0.307 0.409 10 Table 12. Provided are the values of each of the parameters measured in

Arabidopsis ecotypes: 6 = Vegetative growth rate (cm2/day) until 8 true leaves; 3 = relative root growth (cm/day) (day 13); 2 = Root length day 7 (cm); 1 = Root length day 13 (cm); 4 = fresh weight per plant (gr) at bolting stage; 9. = Lamima length (cm); 8 = Lamina width (cm); 18 = Leaf width/length; 7 = Blade circularity. 15

Table 13, below, provides selected genes of some embodiments of the invention, the characterized parameters (which are used as x axis for correlation) and the correlated tissue transcriptom along with the correlation value (R, calculated using Pearson correlation). When the correlation coefficient (R) between the levels of a gene’s 20 expression in a certain tissue and a phenotypic performance across ecotypes is high in absolute value (between 0.5-1), there is an association between the gene (specifically the expression level of this gene) and the phenotypic character.

Table 13 25 Correlation between the expression level of selected genes in specific tissues or developmental stages and the phenotypic performance across Arabidopsis ecotypes

Gene Name Expression Set Correlation Vector R P LYM88 E 13 0.75035 0.03198 LYM89 D 10 0.88062 0.00886 LYM89 D 4 0.84712 0.01614 LYM89 A 6 0.84690 0.00797 LYM89 D 5 0.83715 0.01879 137 LYM89 D 6 0.70174 0.07884 LYM152 E 14 0.85500 0.00682

Table 13. Provided are the correlations between the expression level of yield improving genes and their homologs in specific tissues or developmental stages (expression sets) and the phenotypic performance (correlation vector) across Arabidopsis ecotypes. The phenotypic characters [correlation (Corr.) vector (Vec.)] 5 include yield (seed yield, oil yield, oil content), biomass, growth rate and/or vigor components as described in Tables 10-12. Exp. Set = expression set according to Table 9 hereinabove. 2016213786 11 Aug 2016

10 EXAMPLES

PRODUCTION OF ARABIDOPSIS TRANSCRIPTOM AND HIGH THROUGHPUT CORRELATION ANALYSIS OF NORMAL AND NITROGEN LIMITING CONDITIONS USING 44K ARABIDOPSIS OLIGONUCLEOTIDE

MICRO-ARRAY 15 In order to produce a high throughput correlation analysis, the present inventors utilized a Arabidopsis oligonucleotide micro-array, produced by Agilent Technologies [Hypertext Transfer Protocol://World Wide Web (dot) chem (dot) agilent (dot) com/Scripts/PDS (dot) asp?lPage=50879], The array oligonucleotide represents about 44,000 Arabidopsis genes and transcripts. To define correlations between the levels of 20 RNA expression with NUE, yield components or vigor related parameters various plant characteristics of 14 different Arabidopsis ecotypes were analyzed. Among them, ten ecotypes encompassing the observed variance were selected for RNA expression analysis. The correlation between the RNA levels and the characterized parameters was analyzed using Pearson correlation test [Hypertext Transfer Protocol ://World Wide Web 25 (dot) davidmlane (dot) com/hyperstat/A34739 (dot) html].

Experimental procedures RNA extraction - Two tissues of plants [leaves and stems] growing at two different nitrogen fertilization levels (1.5 mM Nitrogen or 6 mM Nitrogen) were sampled and RNA was extracted as described in Examples 3 above. For convenience, 30 each micro-array expression information tissue type has received a Set ID as summarized in Table 14 below. 2016213786 11 Aug 2016 138

Table 14

Tissues used for Arabidopsis transcriptom expression sets

Expression Set Set ID Leaves at 1.5 mM Nitrogen fertilization A Leaves at 6 mM Nitrogen fertilization B Stems at 1.5 mM Nitrogen fertilization C Stem at 6 mM Nitrogen fertilization D

Table 14: Provided are the identification (ID) letters of each of the Arabidopsis 5 expression sets.

Assessment of Arabidopsis yield components and vigor related parameters under different nitrogen fertilization levels - 10 Arabidopsis accessions in 2 repetitive plots each containing 8 plants per plot were grown at greenhouse. The growing protocol 10 used was as follows: surface sterilized seeds were sown in Eppendorf tubes containing 0.5 x Murashige-Skoog basal salt medium and grown at 23 °C under 12-hour light and 12-hour dark daily cycles for 10 days. Then, seedlings of similar size were carefully transferred to pots filled with a mix of perlite and peat in a 1:1 ratio. Constant nitrogen limiting conditions were achieved by irrigating the plants with a solution containing 1.5 15 mM inorganic nitrogen in the form of KN03, supplemented with 2 mM CaCl2, 1.25 mM KH2PO4, 1.50 mM MgSC>4, 5 mM KC1, 0.01 mM H3BO3 and microelements, while normal irrigation conditions (Normal Nitrogen conditions) was achieved by applying a solution of 6 mM inorganic nitrogen also in the form of KN03, supplemented with 2 mM CaCl2, 1.25 mM KH2P04, 1.50 mM MgSC>4, 0.01 mM H3BO3 and microelements. 20 To follow plant growth, trays were photographed the day nitrogen limiting conditions were initiated and subsequently every 3 days for about 15 additional days. Rosette plant area was then determined from the digital pictures. ImageJ software was used for quantifying the plant size from the digital pictures [Hypertext Transfer Protocol://rsb (dot) info (dot) nih (dot) gov/ij/] utilizing proprietary scripts designed to analyze the size 25 of rosette area from individual plants as a function of time. The image analysis system included a personal desktop computer (Intel P4 3.0 GHz processor) and a public domain program - ImageJ 1.37 (Java based image processing program, which was developed at the U.S. National Institutes of Health and freely available on the internet [Hypertext Transfer Protocol://rsbweb (dot) nih (dot) gov/]. Next, analyzed data was saved to text 30 files and processed using the JMP statistical analysis software (SAS institute).

Data parameters collected are summarized in Table 15, hereinbelow. 2016213786 11 Aug 2016 139

Table 15

Arabidopsis correlated parameters (vectors)

Correlated parameter with Correlation Id N 1.5 mM; Rosette Area at day 8 [cm2l 1 N 1.5 mM; Rosette Area at day 10 [cm2l 2 N 1.5 mM; Plot Coverage at day 8 [%1 3 N 1.5 mM; Plot Coverage at day 10 [%1 4 N 1.5 mM; Leaf Number at day 10 5 N 1.5 mM; Leaf Blade Area at day 10 [cm2] 6 N 1.5 mM; RGR of Rosette Area at day 3 [cm2/day] 7 N 1.5 mM; t50 Flowering [dayl 8 N 1.5 mM; Dry Weight [gr/plant] 9 N 1.5 mM; Seed Yield [gr/plant] 10 N 1.5 mM; Harvest Index 11 N 1.5 mM; 1000 Seeds weight [gr] 12 N 1.5 mM; seed yield/ rosette area at day 10 [gr/cm2] 13 Λ N 1.5 mM; seed yield/leaf blade [gr/cm ] 14 N 1.5 mM; % Seed yield reduction compared to N 6 mM 15 N 1.5 mM; % Biomass reduction compared to N 6 mM 16 N 1.5 mM; N level /DW [SPAD unit/grl 17 N 1.5 mM; DW/ N level [gr/ SPAD unitl 18 N 1.5 mM; seed yield/ N level [gr/ SPAD unit] 19 N 6 mM; Rosette Area at day 8 [cm2] 20 N 6 mM; Rosette Area at day 10 [cm2] 21 N 6 mM; Plot Coverage at day 8 [%1 22 N 6 mM; Plot Coverage at day 10 [%1 23 N 6 mM; Leaf Number at day 10 24 N 6 mM; Leaf Blade Area at day 10 25 N 6 mM; RGR of Rosette Area at day 3 [cm2/gr] 26 N 6 mM; t50 Flowering [day] 27 N 6 mM; Dry Weight [gr/plant] 28 N 6 mM; Seed Yield [gr/plant] 29 N 6 mM; Harvest Index 30 N 6 mM; 1000 Seeds weight [grl 31 N 6 mM; seed yield/ rosette area day at day 10 [gr/cm2l 32 N 6 mM; seed yield/leaf blade [gr/cm2] 33 N 6 mM; N level / FW 34 N 6 mM; DW/ N level [gr/ SPAD unit] 35 N 6 mM; N level /DW (SPAD unit/gr plant) 36 N 6 mM; Seed yield/N unit [gr/ SPAD unit] 37

Table 15. Provided are the Arabidopsis correlated parameters (vectors). “N” = 5 Nitrogen at the noted concentrations; “gr.” = grams; “SPAD” = chlorophyll levels; “t50” = time where 50% of plants flowered; “gr/ SPAD unit” = plant biomass expressed in grams per unit of nitrogen in plant measured by SPAD. “DW” = Plant Dry Weight; "FW" = Plant Fresh weight; “N level /DW” = plant Nitrogen level measured in SPAD unit per plant biomass [gr]; “DW/ N level” = plant biomass per 10 plant [gr]/SPAD unit; Rosette Area (measured using digital analysis); Plot Coverage at the indicated day [%] (calculated by the dividing the total plant area with the total plot 2016213786 11 Aug 2016 140 area); Leaf Blade Area at the indicated day [cm2] (measured using digital analysis); RGR (relative growth rate) of Rosette Area at the indicated day [cm2/day]; t50 Flowering [day] (the day in which 50% of plant flower); seed yield/ rosette area at day 10 [gr/cm2] (calculated); seed yield/leaf blade [gr/cm2] (calculated); seed yield/ N 5 level [gr/ SPAD unit] (calculated).

Assessment of NUE, yield components and vigor-related parameters - Ten

Arabidopsis ecotypes were grown in trays, each containing 8 plants per plot, in a greenhouse with controlled temperature conditions for about 12 weeks. Plants were 10 irrigated with different nitrogen concentration as described above depending on the treatment applied. During this time, data was collected documented and analyzed. Most of chosen parameters were analyzed by digital imaging.

Digital imaging - Greenhouse assay

An image acquisition system, which consists of a digital reflex camera (Canon 15 EOS 400D) attached with a 55 mm focal length lens (Canon EF-S series) placed in a custom made Aluminum mount, was used for capturing images of plants planted in containers within an environmental controlled greenhouse. The image capturing process is repeated every 2-3 days starting at day 9-12 till day 16-19 (respectively) from transplanting. 20 An image processing system was used, which consists of a personal desktop computer (Intel P4 3.0 GHz processor) and a public domain program - ImageJ 1.37, Java based image processing software, which was developed at the U.S. National Institutes of Health and is freely available on the internet at Hypertext Transfer Protocol://rsbweb (dot) nih (dot) gov/. Images were captured in resolution of 10 Mega 25 Pixels (3888x2592 pixels) and stored in a low compression JPEG (Joint Photographic Experts Group standard) format. Next, image processing output data was saved to text files and analyzed using the JMP statistical analysis software (SAS institute).

Leaf analysis - Using the digital analysis leaves data was calculated, including leaf number, leaf blade area, plot coverage, Rosette diameter and Rosette area. 30 Relative growth rate area: The relative growth rate of the rosette and the leaves was calculated according to Formulas XIV and XVII, respectively.

Seed yield and 1000 seeds weight - At the end of the experiment all seeds from all plots were collected and weighed in order to measure seed yield per plant in terms of total seed weight per plant (gr). For the calculation of 1000 seed weight, an average 2016213786 11 Aug 2016 141 weight of 0.02 grams was measured from each sample, the seeds were scattered on a glass tray and a picture was taken. Using the digital analysis, the number of seeds in each sample was calculated.

Dry weight and seed yield - At the end of the experiment, plant were harvested 5 and left to dry at 30 °C in a drying chamber. The biomass was separated from the seeds, weighed and divided by the number of plants. Dry weight = total weight of the vegetative portion above ground (excluding roots) after drying at 30 °C in a drying chamber.

Harvest Index (seed) - The harvest index was calculated using Formula IV as 10 described above [Harvest Index = Average seed yield per plant/ Average dry weight], T50 days to flowering - Each of the repeats was monitored for flowering date. Days of flowering was calculated from sowing date till 50 % of the plots flowered.

Plant nitrogen level - The chlorophyll content of leaves is a good indicator of the nitrogen plant status since the degree of leaf greenness is highly correlated to this 15 parameter. Chlorophyll content was determined using a Minolta SPAD 502 chlorophyll meter and measurement was performed at time of flowering. SPAD meter readings were done on young fully developed leaf. Three measurements per leaf were taken per plot. Based on this measurement, parameters such as the ratio between seed yield per nitrogen unit [seed yield/N level = seed yield per plant [gr]/SPAD unit], plant DW per 20 nitrogen unit [DW/ N level= plant biomass per plant [g]/SPAD unit], and nitrogen level per gram of biomass [N levcl/DW= SPAD unit/ plant biomass per plant (gr)] were calculated.

Percent of seed yield reduction- measures the amount of seeds obtained in plants when grown under nitrogen-limiting conditions compared to seed yield produced 25 at normal nitrogen levels expressed in %.

Experimental Results 10 different Arabidopsis accessions (ecotypes) were grown and characterized for 37 parameters as described above. The average for each of the measured parameters was calculated using the JMP software. Subsequent correlation analysis between the various 30 transcriptom sets (Table 14) was conducted. Following are the results integrated to the database. 2016213786 11 Aug 2016 5 142

Table 16

Correlation between the expression level of selected genes of the invention and their homologs in tissues under limiting or normal nitrogen fertilization and the phenotypic performance across Arabidopsis ecotypes

Gene Name Expression Set Correlation Vector R P LYM88 C 17 0.93533 0.01955 LYM88 D 16 0.79502 0.01044 LYM8 HI D 31 0.745282 0.021184 LYM10 H7 C 24 0.895562 0.000458 LYM10 H7 C 5 0.77817 0.008026 LYM10 H7 C 21 0.725922 0.017459 LYM10 H7 C 2 0.717752 0.019423 LYM10 H8 C 8 0.850748 0.001806 LYM10 H8 C 27 0.7752 0.008432 LYM10 H8 C 15 0.77175 0.008921 LYM10 H9 A 1 0.844351 0.002119 LYM10 H9 A 2 0.755723 0.01146 LYM10 H9 A 20 0.733447 0.015776 LYM10 H9 A 21 0.722114 0.018356 LYM14 H2 B 27 0.892136 0.000519 LYM14 H2 B 8 0.830273 0.002942 LYM14 H2 C 8 0.816286 0.003967 LYM14 H2 C 8 0.794197 0.006071 LYM14 H2 C 27 0.767463 0.009557 LYM14 H2 C 27 0.733255 0.015818 LYM14 H2 D 1 0.725116 0.027066 LYM14 H3 B 15 0.855842 0.001582 LYM14 H3 C 8 0.802977 0.005158 LYM14 H3 B 8 0.79811 0.005651 LYM14 H3 B 12 0.792747 0.006233 LYM14 H3 B 27 0.785721 0.007057 LYM14 H3 C 27 0.734206 0.015613 LYM14 H3 A 9 0.720081 0.018848 LYM137 HI 1 C 20 0.815207 0.004055 LYM137 Hll c 21 0.79814 0.005648 LYM137 Hll D 5 0.754601 0.018779 LYM137 Hll C 24 0.701843 0.023676 LYM152 HI D 5 0.714383 0.030592 LYM152 HI D 5 0.713442 0.030914 LYM236 H4 B 27 0.937557 6.17E-05 LYM236 H4 B 8 0.921247 0.000153 LYM236 H4 B 15 0.865782 0.001204 LYM236 H4 B 28 0.709595 0.02153 LYM236 H5 A 10 0.737484 0.014922 LYM236 H5 B 10 0.71158 0.021004

Table 16. Provided are the correlations (R) between the expression levels of yield improving genes and their homologs in tissues (leaves or stems) under limiting (1.5 mM Nitrogen) or normal (6 mM Nitrogen) conditions (Expression sets) and the phenotypic performance in various yield (seed yield, oil yield, oil content), biomass, growth rate and/or vigor components [Correlation (Corr.) vector (Vec.)] under limiting or normal Nitrogen conditions. Corr. Vec. = correlation vector according to Table 15 hereinabove; Exp. Set = expression set according to Table 14 hereinabove. 10 2016213786 11 Aug 2016 143 EXAMPLE 6

PRODUCTION OF SORGHUM TRANSCRIPTOM AND HIGH THROUGHPUT CORRELATION ANALYSIS WITH ABST RELATED PARAMETRERS USING 44K SORGUHM OLIGONUCLEOTIDE MICRO-ARRAYS 5 In order to produce a high throughput correlation analysis, the present inventors utilized a Sorghum oligonucleotide micro-array, produced by Agilent Technologies [Hypertext Transfer Protocol ://World Wide Web (dot) chem. (dot) agilent (dot) com/Scripts/PDS (dot) asp?lPage=50879], The array oligonucleotide represents about 44,000 Sorghum genes and transcripts. In order to define correlations between the 10 levels of RNA expression with ABST and yield components or vigor related parameters, various plant characteristics of 17 different sorghum varieties were analyzed. Among them, 10 varieties encompassing the observed variance were selected for RNA expression analysis. The correlation between the RNA levels and the characterized parameters was analyzed using Pearson correlation test [Hypertext 15 Transfer Protocol://World Wide Web (dot) davidmlane (dot) com/hyperstat/A34739 (dot) html].

Correlation of Sorghum varieties across ecotype grown under severe drought conditions

Experimental procedures 20 17 Sorghum varieties were grown in 3 repetitive plots, in field. Briefly, the growing protocol was as follows: sorghum seeds were sown in soil and grown under normal condition until around 35 days from sowing, around V8 (Last leaf visible, but still rolled up, ear beginning to swell). At this point, irrigation was stopped, and severe drought stress was developed. In order to define correlations between the levels of RNA 25 expression with drought, yield components or vigor related parameters, the 17 different sorghum varieties were analyzed. Among them, 10 varieties encompassing the observed variance were selected for RNA expression analysis. The correlation between the RNA levels and the characterized parameters was analyzed using Pearson correlation test [Hypertext Transfer Protocol://World Wide Web (dot) davidmlane (dot) 30 com/hyperstat/A34739 (dot) html], RNA extraction - All 10 selected Sorghum varieties were sample per each treatment. Plant tissues [Flag leaf, Flower meristem and Flower] growing under severe 2016213786 11 Aug 2016

Expression Set Set ID Sorghum field/Normal/flower meristem 1 Sorghum field/Normal/flower 2 Sorghum field/Normal/flag leaf 3 Drought Stress: Flag leaf 4 Table 17: Provided are the sorghum transcriptom expression sets 1, 2, 3 and 4. 144 drought stress and plants grown under Normal conditions were sampled and RNA was extracted as described in Examples 3 above. For convenience, each micro-array expression information tissue type has received a Set ID as summarized in Table 17 below. 5

Table 17

Sorghum transcriptom expression sets 10 Flag leaf = the leaf below the flower; Flower meristem = Apical meristem following panicle initiation; Flower = the flower at the anthesis day. Expression sets 1, 2 and 3 are from plants grown under normal conditions. Expression set 4 derived from plants grown under drought conditions. 15 The following parameters were collected using digital imaging system:

Average Grain Area (cm2) - At the end of the growing period the grains were separated from the Plant ‘Head’. A sample of -200 grains were weight, photographed and images were processed using the below described image processing system. The grain area was measured from those images and was divided by the number of grains. 20 Average Grain Length (cm) - At the end of the growing period the grains were separated from the Plant ‘Head’. A sample of -200 grains were weight, photographed and images were processed using the below described image processing system. The sum of grain lengths (longest axis) was measured from those images and was divided by the number of grains. 25 Head Average Area (cm2) At the end of the growing period 5 ‘Heads’ were, photographed and images were processed using the below described image processing system. The ‘Head’ area was measured from those images and was divided by the number of ‘Heads’.

Head Average Length (cm) At the end of the growing period 5 ‘Heads’ were, 30 photographed and images were processed using the below described image processing system. The ‘Head’ length (longest axis) was measured from those images and was divided by the number of ‘Heads’. 2016213786 11 Aug 2016 145

The image processing system was used, which consists of a personal desktop computer (Intel P4 3.0 GHz processor) and a public domain program - ImageJ 1.37, Java based image processing software, which was developed at the U.S. National Institutes of Health and is freely available on the internet at Hypertext Transfer 5 Protocol://rsbweb (dot) nih (dot) gov/. Images were captured in resolution of 10 Mega

Pixels (3888x2592 pixels) and stored in a low compression JPEG (Joint Photographic Experts Group standard) format. Next, image processing output data for seed area and seed length was saved to text files and analyzed using the JMP statistical analysis software (SAS institute). 10 Additional parameters were collected either by sampling 5 plants per plot or by measuring the parameter across all the plants within the plot.

Total Seed Weight/Head (gr.) - At the end of the experiment (plant ‘Heads’) heads from plots within blocks A-C were collected. 5 heads were separately threshed and grains were weighted, all additional heads were threshed together and weighted as 15 well. The average grain weight per head was calculated by dividing the total grain weight by number of total heads per plot (based on plot). In case of 5 heads, the total grains weight of 5 heads was divided by 5. FW Head/Plant gr - At the end of the experiment (when heads were harvested) total and 5 selected heads per plots within blocks A-C were collected separetaly. The 20 heads (total and 5) were weighted (gr.) separately and the average fresh weight per plant was calculated for total (FW Head/Plant gr based on plot) and for 5 (FW Head/Plant gr based on 5 plants).

Plant height - Plants were characterized for height during growing period at 5 time points. In each measure, plants were measured for their height using a measuring 25 tape. Height was measured from ground level to top of the longest leaf.

Plant leaf number - Plants were characterized for leaf number during growing period at 5 time points. In each measure, plants were measured for their leaf number by counting all the leaves of 3 selected plants per plot.

Relative Growth Rate was calculated using Formulas X and XI.

30 Formula X

Relative growth rate of plant height = Regression coefficient of plant height along time course. 2016213786 11 Aug 2016 146

Formula XI

Relative growth rate of plant leaf number = Regression coefficient of plant leaf number along time course. SPAD - Chlorophyll content was determined using a Minolta SPAD 502 5 chlorophyll meter and measurement was performed 64 days post sowing. SPAD meter readings were done on young fully developed leaf. Three measurements per leaf were taken per plot.

Vegetative dry weight and Heads - At the end of the experiment (when Inflorescence were dry) all Inflorescence and vegetative material from plots within 10 blocks A-C were collected. The biomass and Heads weight of each plot was separated, measured and divided by the number of Heads.

Dry weight = total weight of the vegetative portion above ground (excluding roots) after drying at 70 °C in oven for 48 hours;

Harvest Index (HI) (Sorghum)- The harvest index was calculated using 15 Formula XII.

Formula XII:

Harvest Index = Average grain dry weight per Head / (Average vegetative dry weight per Head + Average Head dry weight) FW Heads/(FW Heads + FW Plants) - The total fresh weight of heads and their 20 respective plant biomass were measured at the harvest day. The heads weight was divided by the sum of weights of heads and plants.

Experimental Results 16 different sorghum varieties were grown and characterized for different parameters: The average for each of the measured parameter was calculated using the 25 JMP software (Tables 19-20) and a subsequent correlation analysis between the various transcriptom sets (Table 17) and the average parameters, was conducted (Tables 21). Results were then integrated to the database.

Table 18 30 Sorghum correlated parameters (vectors)

Correlation Vector Correlation Id Average Seed Area cm2-normal A Average Seed Length cm-normal B FW/Plant gr based on plot-normal C 147

FW Head/Plant gr based on 5 plants-normal D FW Head/Plant gr based on plot-normal E FW Heads/(FW Heads + FW Plants) based on plot-normal F Head Average Area cm2-normal G Head Average Length cm-normal H HI-normal J Leaf SPAD 64 Days Post Sowing-normal K Relative Growth Rate of Leaf Num-normal L Relative Growth Rate of Plant Height-normal M Total Seed Weight/Head gr based on plot-normal N Total Seed Weight /Head gr based on 5 heads-normal O

Table 18. Provided are the Sorghum correlated parameters (vectors), “gr.” = grams; “SPAD” = chlorophyll levels; "FW" = Plant Fresh weight;”normal” = standard growth conditions. 2016213786 11 Aug 2016 5 Table 19

Measured parameters in Sorghum accessions

Seed Id A B C D E F G H J 20 0.1047 0.3856 162.6 406.5 175.2 0.51 120.1 25.58 200.7 21 0.1124 0.4017 212.6 518 223.5 0.5101 167.6 26.84 127 22 0.1313 0.4446 334.8 148 56.4 0.1154 85.14 21.02 51.8 24 0.1293 0.4496 313.5 423 111.6 0.2626 157.3 26.84 122.4 25 0.1204 54.53 26 0.177 93.92 27 0.1098 0.3999 151.1 423.5 126.2 0.4591 168.5 31.33 327.3 28 0.1134 0.4054 137.6 386.5 107.7 0.4316 109.3 23.18 231.5 29 0.1022 0.3837 168 409.5 123.9 0.4249 135.1 25.7 241.4 30 0.118 0.4186 129 328.9 102.8 0.4416 169 28.82 304.1 31 0.1205 0.4302 97.62 391 82.33 0.4581 156.1 28.13 335.6 32 0.1106 0.4003 99.32 435.8 77.59 0.4473 112.1 22.97 349.6 33 0.1165 0.4094 112.2 429.5 91.17 0.4474 154.7 28.09 293.2 34 0.108 0.4008 157.4 441 150.4 0.5134 171.7 30 410.9 35 0.1048 0.3947 130.5 415.8 109.1 0.4595 168.5 30.54 285.1 36 0.1097 0.3953 135.7 429.5 107.6 0.4425 162.5 27.17 282.7 37 0.1053 0.3924 209.2 428.5 130.9 0.3856 170.5 29.26 204

Table 19: Provided are the values of each of the parameters (as described above) measured in Sorghum accessions (Seed ID) under normal and drought conditions. Growth conditions are specified in the experimental procedure section. 10

Table 20

Additional measured parameters in Sorghum accessions

Seed Id L M N O 20 0.1032 1.891 31.12 47.4 21 1.622 26.35 46.3 22 0.2128 3.418 18.72 28.37 24 0.1862 2.425 38.38 70.4 25 0.1898 3.118 26 0.1599 3.323 27 0.1957 2.178 47.67 63.45 148

Seed Id L M N O 28 0.1694 2.188 31 44.45 29 0.1821 2.572 39.99 56.65 30 2.046 38.36 60 31 2.069 32.1 45.45 32 0.1754 2.547 32.69 58.19 33 0.117 2.327 32.79 70.6 34 0.207 3.039 51.53 70.1 35 0.1859 2.335 35.71 53.95 36 0.151 2.516 38.31 59.87 37 0.24 2.81 42.44 52.65 Table 20: Provided are the values of each of the parameters (as c escribed above) measured in Sorghum accessions (Seed ID) under normal and drought conditions. Growth conditions are specified in the experimental procedure section. 2016213786 11 Aug 2016 5 Table 21

Correlation between the expression level of selected genes of some embodiments of the invention in various tissues and the phenotypic performance under normal or abiotic stress conditions across Sorghum accessions

Gene Name Cluster Name Exp. Set Corr. Vec. R P LYM174 sorghum |gbl61.crp|AW284303 1 J 0.746 0.013251 LYM263 sorghum|gb 161 ,crp| AI622410 2 O 0.860 0.00292 LYM263 sorghum gb 161 .crp AI622410 2 J 0.847 0.00196 LYM5 H21 sorghum 09vlSB04G031180 1 B 0.898 0.00101 LYM5 H21 sorghum 09vlSB04G031180 1 A 0.896 0.00107 LYM8 H23 sorghum|09v 1 |SB01G000490 1 O 0.755 0.018718 LYM8 H23 sorghum|09v 1 |SB01G000490 2 O 0.714 0.030884 LYM10 H272 sorghum|09v 1ISB04G005280 3 L 0.756 0.029952 LYM14 H44 sorghum|09vl ISB02G044050 2 E 0.769 0.015504 LYM24 H10 sorghum|09vl ISB03G044280 2 C 0.774 0.014343 LYM24 H10 sorghum|09vl ISB03G044280 3 B 0.743 0.021898 LYM24 H10 sorghum|09vl ISB03G044280 3 A 0.728 0.026226 LYM35 H7 sorghum|09vl|SB06G031730 2 E 0.823 0.006385 LYM73 H8 sorghum| 09v 11SB07G004300 1 E 0.748 0.02039 LYM82 H16 sorghum| 09v 11 SB 10G002420 3 J 0.783 0.007439 LYM82 H16 sorghum| 09v 11 SB 10G002420 3 N 0.780 0.013111 LYM82 H16 sorghum| 09v 11 SB 10G002420 3 O 0.726 0.02673 LYM82 H16 sorghum| 09v 11 SB 10G002420 3 G 0.723 0.027818 LYM111 H10 sorghum| 09v 11SB03G036350 3 C 0.892 0.00122 LYM111 H10 sorghum| 09v 11SB03G036350 3 A 0.753 0.019062 LYM111 H10 sorghum| 09v 11SB03G036350 3 B 0.702 0.035192 LYM119H1 sorghum| 09v 1|SB05G003680 2 C 0.759 0.017691 LYM131 H19 sorghum| 09v 11SB06G027970 1 E 0.841 0.004488 LYM131 H19 sorghum| 09v 1|SB06G027970 3 B 0.787 0.011775 LYM131 H19 sorghum 09vlSB06G027970 3 A 0.762 0.017013 LYM131 H19 sorghum 09vlSB06G027970 1 F 0.700 0.024184 LYM131 H20 sorghum 09vlSB07G006320 1 E 0.854 0.003353 LYM137H285 sorghum 09vlSB06G021660 2 F 0.747 0.013056 LYM137H285 sorghum 09vlSB06G021660 1 E 0.716 0.030132 LYM137H286 sorghum 09vl SB 10G005240 1 E 0.786 0.012037 LYM140 H27 sorghum 09vlSB06G028990 1 C 0.772 0.014832 LYM148 H14 sorghum 09v 1 SB 10G026570 1 B 0.812 0.007885 2016213786 11 Aug 2016 149 Gene Name Cluster Name Exp. Set Corr. Vec. R P LYM148 H14 sorghuml 09v 11 SB 10G026570 1 A 0.770 0.015311 LYM148 H14 sorghuml 09v 11 SB 10G026570 1 C 0.768 0.015705 LYM162 H7 sorghum|09vl|SB03G043995 1 N 0.837 0.004911 LYM215 H2 sorghum|09vl|SB03G043980 1 N 0.718 0.029262 LYM178 H13 sorghum|09vl|SB03G008890 3 B 0.862 0.002833 LYM178 H13 sorghum|09vl|SB03G008890 3 A 0.792 0.010892 LYM178 H14 sorghum|09vl|SB07G001060 2 A 0.768 0.01572 LYM179 HO sorghum|09vl|SB08G006470 1 O 0.818 0.006992 LYM109 H2 sorghum|09vl|SB05G003660 1 B 0.762 0.017077 LYM109 H2 sorghum|09vl|SB05G003660 3 A 0.751 0.019579 LYM109 H2 sorghum|09vl|SB05G003660 1 A 0.732 0.025074 LYM112H2 sorghum|09vl|SB02G039985 1 B 0.827 0.005944 LYM112H2 sorghum|09vl|SB02G039985 3 B 0.790 0.011246 LYM112H2 sorghum|09vl|SB02G039985 1 A 0.789 0.011426 LYM112H2 sorghum|09vl|SB02G039985 3 A 0.701 0.035452 LYM123 H7 sorghum|09vl|SB06G031680 1 B 0.769 0.015524 LYM181 H6 sorghuml 09v 11SB02G034110 1 B 0.740 0.022556 LYM181 H6 sorghuml 09v 11SB02G034110 3 N 0.724 0.027264 LYM181 H6 sorghuml 09v 11SB02G034110 3 O 0.702 0.035114 LYM182H12 sorghuml 09vl|SB06G015280 1 E 0.767 0.015834 LYM206 H2 sorghuml 09vl|SB07G021090 3 N 0.795 0.010488 LYM188H13 sorghuml 09vl|SB01G007950 1 E 0.788 0.011658 LYM198 HI sorghuml 09vl|SB01G045460 1 E 0.829 0.005689 LYM201 H37 sorghuml 09v 11SB04G0223 50 2 N 0.741 0.022246 LYM201 H37 sorghuml 09v 11SB04G0223 50 2 D 0.709 0.032326 LYM201 H37 sorghuml 09v 11SB04G0223 50 2 H 0.701 0.035468 LYM207 H3 sorghuml 09vl|SB06G023 870 3 K 0.781 0.007669 LYM207 H3 sorghuml 09vl|SB06G023 870 1 E 0.768 0.015595 LYM207 H3 sorghuml 09vl|SB06G023 870 3 O 0.718 0.029344 LYM207 H3 sorghuml 09vl|SB06G023 870 1 N 0.716 0.02988 LYM208 H8 sorghuml 09vl|SB01G032070 1 N 0.734 0.024302 LYM208 H8 sorghuml 09vl|SB01G032070 1 E 0.701 0.03525 LYM212H9 sorghuml 09vl|SB01G045480 1 E 0.841 0.004537 LYM221 H3 sorghuml 09v 11SB01G034610 2 A 0.728 0.02604 LYM221 H3 sorghuml 09v 11SB01G034610 2 C 0.721 0.028264 LYM224 H3 sorghuml 09vl|SB02G040000 3 C 0.835 0.005096 LYM224 H3 sorghuml 09vl|SB02G040000 3 L 0.827 0.011397 LYM224 H3 sorghuml 09vl|SB02G040000 3 M 0.708 0.021888 LYM232 H3 sorghuml 09vl|SB02G000450 1 O 0.808 0.00839 LYM232 H3 sorghuml 09vl|SB02G000450 1 N 0.759 0.017814 LYM236H139 sorghuml 09vl|SB09G029110 1 A 0.859 0.00303 LYM236H139 sorghuml 09vl|SB09G029110 1 B 0.836 0.004971 LYM248 H5 sorghuml 09vl|SB04G000645 3 L 0.878 0.004118 LYM248 H5 sorghuml 09vl|SB04G000645 1 N 0.868 0.002424 LYM183 HI 1 sorghuml 09vl|SB01G003070 1 E 0.832 0.005437 LYM183 HI 1 sorghuml 09vl|SB01G003070 1 N 0.749 0.020124 LYM267 HI sorghuml 09v 11SB01G044240 2 A 0.797 0.010102 LYM267 HI sorghuml 09v 11SB01G044240 2 B 0.753 0.019206 LYM267 HI sorghuml 09v 11SB01G044240 1 H 0.707 0.033248 LYM267 HI sorghuml 09v 11SB01G044240 1 O 0.705 0.033872 LYM267 HI sorghuml 09v 11SB01G044240 1 N 0.705 0.033976 LYM270 HO sorghuml 09vl|SB02G040045 1 E 0.820 0.006742 LYM271 H10 sorghuml 09vl|SB02G040020 1 N 0.780 0.013152 LYM273 H6 sorghuml 09v 11SB03G044410 3 B 0.955 5.91E-05 150

Gene Name Cluster Name Exp. Set Corr. Vec. R P LYM273 H6 sorghum 09v 11SB03G044410 3 A 0.950 8.6E-05 LYM284 H24 sorghum 09vl|SB03G027960 1 E 0.867 0.00247 LYM289 H52 sorghum 09vlSB09G005410 3 O 0.928 0.000307 LYM289 H52 sorghum 09vl|SB09G005410 3 N 0.830 0.005588 LYM289 H52 sorghum 09vl|SB09G005410 3 H 0.781 0.012924 LYM289 H52 sorghum 09vl|SB09G005410 3 G 0.714 0.03066 LYM289 H52 sorghum|09vl|SB09G005410 3 D 0.704 0.03412 LYM290 HI3 sorghum 09vlSB01G009390 1 E 0.766 0.01617

Table 21. Provided are the correlations (R) between the expression levels of yield improving genes and their homologs in tissues (Flag leaf, Flower meristem and Flower; Expression (Exp.) sets) and the phenotypic performance in various yield, biomass, growth rate and/or vigor components [Correlation (Corr.) vector (Vec.)] under stress conditions or normal conditions across Sorghum accessions. 2016213786 11 Aug 2016 5

Sorghum vigor related parameters under 100 mM NaCl and low temperature (10±2°C)-Ten Sorghum varieties were grown in 3 repetitive plots, each containing 17 plants, at a net house under semi-hydroponics conditions. Briefly, the growing 10 protocol was as follows: Sorghum seeds were sown in trays filled with a mix of vermiculite and peat in a 1:1 ratio. Following germination, the trays were transferred to the high salinity solution (100 mM NaCl in addition to the Full Hogland solution), low temperature (10 ± 2 °C in the presence of Full Hogland solution) or at Normal growth solution [Full Hogland solution at 28 ± 2 °C], 15 Full Hogland solution consists of: KN03 - 0.808 grams/liter, MgS04 - 0.12 grams/liter, KH2PO4 - 0.172 grams/liter and 0.01 % (volume/volume) of‘Super coratin' micro elements (Iron-EDDHA [ethylenediamine-N,N'-bis(2-hydroxyphenylacetic acid)]- 40.5 grams/liter; Mn - 20.2 grams/liter; Zn 10.1 grams/liter; Co 1.5 grams/liter; and Mo 1.1 grams/liter), solution’s pH should be 6.5 - 6.8]. 20 RNA extraction - All 10 selected Sorghum varieties were sampled per each treatment. Two tissues [leaves and roots] growing at 100 mM NaCl, low temperature (10 ± 2 °C) or under Normal conditions (full Hogland at a temperature between 28 ± 2 °C) were sampled and RNA was extracted as described in Example 3 above. 25 Table 22

Sorghum transcriptom expression sets

Expression Set Set ID Sorghum roots under cold 1 Sorghum vegetative meristem NaCl 2 Sorghum vegetative meristem under low nitrogen 3 Sorghum vegetative meristem under cold conditions 4 Sorghum roots under NaCl 5 151

Expression Set Set ID Sorghum vegetative meristem under normal conditions 6 Sorghum roots under low nitrogen 7 Sorghum roots under normal 8

Table 22: Provided are the Sorghum transcriptom expression sets. Cold conditions = 10 ± 2 °C; NaCl = 100 mM NaCl; low nitrogen =1.2 mM Nitrogen; Normal conditions = 16 mM Nitrogen. 2016213786 11 Aug 2016 5 Experimental Results 10 different Sorghum varieties were grown and characterized for the following parameters: "Leaf number Normal" = leaf number per plant under normal conditions (average of five plants); "Plant Height Normal" = plant height under normal conditions (average of five plants); "Root DW 100 mM NaCl" - root dry weight per plant under 10 salinity conditions (average of five plants); The average for each of the measured parameter was calculated using the JMP software and values are summarized in Table 24 below. Subsequent correlation analysis between the various transcriptom sets and the average parameters were conducted (Table 25). Results were then integrated to the database. 15

Table 23

Sorghum correlated parameters (vectors)

Correlation Vector Corr. Id DW Root/Plant - Cold A DW Root/Plant - 100 mM NaCl B DW Shoot/Plant - Low Nitrogen C DW Root/Plant - Low Nitrogen D Leaf number TP-3* - Cold E Leaf number TP-3*- 100 mM NaCl F Plant Height TP-3*- 100 mM NaCl G DW Shoot/Plant - Cold H DW Shoot/Plant - Normal I Plant Height TP-3* - Low Nitrogen J Leaf number TP-3* - Low Nitrogen K DW Shoot/Plant - 100 mM NaCl L Leaf number TP-3*-Normal M

Table 23: Provided are the Sorghum correlated parameters. Cold conditions = 10 20 ±2 °C; NaCl = 100 mM NaCl; low nitrogen = 1.2 mM Nitrogen; Normal conditions = 16 mM Nitrogen * TP-3 refers to time point 3. 2016213786 11 Aug 2016 5 10 152

Table 24 Sorghum accessions, measured parameters

Seed ID F B L G E A H M / 20 3.67 0.35 0.66 14.63 3.88 0.83 1.03 4.17 0.81 22 3.88 1.45 2.43 16.31 4.16 0.95 1.34 4.48 1.89 26 4.28 1.49 2.40 20.56 4.52 1.47 1.71 4.93 2.51 27 4.03 0.81 1.61 14.70 4.28 1.06 1.28 4.53 1.26 28 3.97 1.03 1.77 16.43 4.33 0.71 1.12 4.52 1.55 29 3.98 0.95 1.66 16.12 4.17 1.38 1.69 4.64 1.50 30 3.90 2.00 2.23 15.61 3.94 2.04 2.24 4.49 1.93 31 4.18 1.39 2.76 18.71 4.26 1.03 1.26 4.79 1.95 34 3.70 1.29 1.29 13.65 4.20 1.01 1.08 4.37 1.48 37 3.82 1.76 1.55 15.72 4.04 1.01 1.02 4.54 1.85 Table 24: Provided are the measured parameters under 100 mM NaCl and low temperature (8-10 °C) conditions of Sorghum accessions (Seed ID) according to the Correlation ID numbers (described in Table 23 above) as follows: F [100 mM NaCl: leaf Number]; B [100 mM NaCl: Root DW]; L [100 mM NaCl: Shoot DW]; G [100 mM NaCl: Plant height]; E [low temperature: leaf Number]; A [low temperature: Root DW]; H [low temperature: Shoot DW];; M [Normal: leaf Number]; I [Normal: Shoot DW],

Table 25 Correlation between the expression level of selected genes of some embodiments of 15 the invention in roots and the phenotypic performance under normal or abiotic stress conditions across Sorghum accessions Gene Name Cluster Id Exp. Set Corr. Vec. R P LYM263 sorghum gb 161. crp AI622410 5 G 0.705635 0.183016 LYM263 sorghum gb 161. crp AI622410 5 F 0.908761 0.032626 LYM263 sorghum gb 161. crp AI622410 8 I 0.836212 0.004969 LYM2 H8 sorghum 09vl SB07G004285 1 A 0.73969 0.01447 LYM4H11 sorghum 09vl SB03G000920 2 B 0.83675 0.00491 LYM4H11 sorghum 09vl SB03G000920 2 B 0.73187 0.02499 LYM4H11 sorghum 09vl SB03G000920 4 E 0.70634 0.03342 LYM14 H43 sorghum 09vl SB01G038730 1 A 0.71433 0.02029 LYM19 H12 sorghum|09vl|SB05G009990 5 F 0.97628 0.00437 LYM19 H12 sorghum|09vl|SB05G009990 5 G 0.88580 0.04552 LYM24H10 sorghum 09vl SB03G044280 4 H 0.75256 0.01929 LYM24H10 sorghum 09vl|SB03G044280 4 H 0.74948 0.02008 LYM73 H8 sorghum|09vl|SB07G004300 5 F 0.97233 0.00550 LYM73 H8 sorghum|09vl ISB07G004300 5 F 0.92449 0.02462 LYM73 H8 sorghum|09vl ISB07G004300 4 E 0.73646 0.02364 LYM83 H12 sorghum|09vl |SB09G026370 2 F 0.70736 0.03305 LYM129 H4 sorghum|09vl ISB03G044510 1 E 0.72429 0.01784 LYM129H4 sorghum|09vl ISB03G044510 2 F 0.72339 0.02761 LYM129H4 sorghum|09vl ISB03G044510 6 I 0.71891 0.02907 LYM129 H4 sorghum|09vl ISB03G044510 6 I 0.71123 0.03168 LYM129 H4 sorghum|09vl ISB03G044510 2 F 0.70792 0.03285 LYM140 H27 sorghum|09vl ISB06G028990 2 G 0.80589 0.00873 LYM140 H27 sorghum|09vl ISB06G028990 2 F 0.78965 0.01136 LYM140 H27 sorghum|09vl ISB06G028990 6 I 0.71625 0.02996 2016213786 11 Aug 2016 153 Gene Name Cluster Id Exp. Set Corr. Vec. R P LYM153 H9 sorghum|09vl|SB10G003440 4 H 0.78966 0.01136 LYM153 H9 sorghum|09vl|SB10G003440 4 H 0.73143 0.02512 LYM153 H9 sorghum|09vl|SB10G003440 4 A 0.71026 0.03202 LYM115 HO sorghum|09vl|SB01G043900 2 F 0.74903 0.02019 LYM188H13 sorghum|09vl |SB01G007950 5 F 0.87882 0.04971 LYM203 H14 sorghum|09vl ISB04G005460 2 B 0.78001 0.01316 LYM217H3 sorghum|09vl |SB01G043910 5 B 0.94269 0.01633 LYM217H3 sorghum|09vl |SB01G043910 5 B 0.93691 0.01884 LYM228 HI sorghum|09vl ISB09G006910 1 A 0.72334 0.01806 LYM232 H3 sorghum|09vl ISB02G000450 2 L 0.77653 0.01385 LYM232 H3 sorghum|09vl ISB02G000450 2 F 0.72326 0.02766 LYM240 H12 sorghum|09vl ISB02G038240 4 H 0.76382 0.01659 LYM240 H12 sorghum|09vl ISB02G038240 2 L 0.73895 0.02293 LYM251 HI 06 sorghum|09v 1 |SB01G006180 5 F 0.95275 0.01224 LYM284 H24 sorghum[09vl ISB03G027960 6 M 0.76300 0.01677 LYM289 H53 sorghum 09vl SB10G002980 5 G 0.91500 0.02936 Table 25. Provided are the correlations (R) between the expression levels yield improving genes and their homologs in various tissues [Expression (Exp.) sets] and the phenotypic performance [yield, biomass, growth rate and/or vigor components (Correlation vector)] under abiotic stress conditions (salinity) or normal conditions 5 across Sorghum accessions. Corr. Vec. = correlation vector as described hereinabove (Table 23). EXAMPLE 7

GENE CLONING AND GENERATION OF BINARY VECTORS FOR PLANT 10 EXPRESSION

To validate their role in improving oil content, plant yield, seed yield, biomass, fiber yield and/or quality, growth rate, ABST, NUE and/or vigor, selected genes were over-expressed in plants, as follows.

Cloning strategy 15 Genes listed in Examples 1-6 hereinabove were cloned into binary vectors for the generation of transgenic plants. For cloning, the full-length open reading frame (ORF) was first identified. In case of ORF-EST clusters and in some cases already published mRNA sequences were analyzed to identify the entire open reading frame by comparing the results of several translation algorithms to known proteins from other 20 plant species. To clone the full-length cDNAs, reverse transcription (RT) followed by polymerase chain reaction (PCR; RT-PCR) was performed on total RNA extracted from leaves, flowers, siliques or other plant tissues, growing under normal conditions. Total RNA was extracted as described in Example 3 above. Production of cDNA and PCR amplification was performed using standard protocols described elsewhere (Sambrook 2016213786 11 Aug 2016 154 J., E.F. Fritsch, and T. Maniatis. 1989. Molecular Cloning. A Laboratory Manual., 2nd Ed. Cold Spring Harbor Laboratory Press, New York.) which are well known to those skilled in the art. PCR products were purified using PCR purification kit (Qiagen). In case where the entire coding sequence was not found, RACE kit from Invitrogen 5 (RACE = R apid A ccess to cDNA E nds) was used to access the full cDNA transcript of the gene from the RNA samples described above.

In case genomic DNA was cloned, as in the case of LYM122 (SEQ ID NO:3739) and LYM273 (SEQ ID NO:3738), the genes were amplified by direct PCR on genomic DNA extracted from leaf tissue using the DNAeasy kit (Qiagen Cat. No. 10 69104).

Usually, 2 sets of primers were synthesized for the amplification of each gene from a cDNA or a genomic sequence; an external set of primers and an internal set (nested PCR primers). When needed (e.g., when the first PCR reaction did not result in a satisfactory product for sequencing), an additional primer (or two) of the nested PCR 15 primers were used. Table 26 below provides primers used for cloning of selected genes.

Table 26

The PCR primers used for cloning the genes of some embodiments of the invention into high copy vectors

Gene Name Restriction Enzymes used for cloning Primers used for amplification LYM1 Sail, Xbal LYM1 NF Sail (SEQ ID NO: 3740) AAAGTCGACAGTAGGCAATCATGTGTGAGG LYM1 NR Xbal (SEQ ID NO: 3741) AATTCTAGACTAAGCTAGAGAGCTCGACTAATGC LYM10 Xhol, Kpnl LYM10 NF Xhol (SEQ ID NO: 3742) AT ACT CGAGTCT CCAACCTT GCGAAGG LYM10 EF Xhol (SEQ ID NO: 3743) ATACTCGAGAACCCGATCTCTCCAACC LYM10 NR Kpnl (SEQ ID NO: 3744) TATGGTACCCCTGCGAATTCTTGCCTTAG LYM10 ER Kpnl (SEQ ID NO: 3745) TATGGTACCTGACGCCACCCTCAACTC LYM100 Sail,Xbal LYM100 NF Sail (SEQ ID NO: 3746) AAAGT CGACAGGAAACCCT AACGAAGATACC LYM100 EF Sail (SEQ ID NO: 3747) AAAGTCGACGGAAACATACAGGTCGATTGAG LYM100 NR Xbal (SEQ ID NO: 3748) AAATCTAGAGGGAAAGTTTAGTAGCACCAAC LYM100 ER Xbal (SEQ ID NO: 3749) AAATCTAGAATATAACGTTAGAGCGGAGTGG LYM102 BamHI,XhoI LYM102 NF BamHI (SEQ ID NO: 3750) AAAGGAT CCGAGCT GCTGATTGT GAGTC AAG 2016213786 11 Aug 2016

155 Gene Name Restriction Enzymes used for cloning Primers used for amplification LYM102 NR Xhol (SEQ ID NO: 3751) AAACTCGAGCTAGGACAGCACTTCAGATAAGACC LYM103 BamHI,XhoI LYM103 NF BamHI (SEQ ID NO: 3752) AAAGGATCCCGACCGAGTCAATCAATCC LYM103 NR Xhol (SEQ ID NO: 3753) AAACTCGAGAACAAGTATGACAGGCCAACTC LYM105 BamHI,XhoI LYM105 NF BamHI (SEQ ID NO: 3754) AAAGGATCCTAGCTAGCTTACTCCACAGTGC LYM105 EF BamHI (SEQ ID NO: 3755) AAAGGATCCAGCCACACGCTTAGCTTAGC LYM105 NR Xhol (SEQ ID NO: 3756) AAACTCGAGCGAGCAGAAATTAACAGCTAAC LYM105 ER Xhol (SEQ ID NO: 3757) AAACTCGAGACTACAGATCCAAAGCACGAAC LYM106 SalI,XbaI LYM106 NF Sail (SEQ ID NO: 3758) AAAGTCGACACTCAACGTAGTTCCTCACCTG LYM106 NR Xbal (SEQ ID NO: 3759) AAATCTAGAAAGCTTTAGTTCTAGCACACGAC LYM107 BamHI,XhoI LYM107 NF BamHI (SEQ ID NO: 3760) AAAGGATCCGTACTCCTATATTAGGCTCGCTC LYM107 EF BamHI (SEQ ID NO: 3761) AAAGGATCCCTGCGTACTCCTATATTAGGCTC LYM107 NR Xhol (SEQ ID NO: 3762) AAACTCGAGAATTTGGTATCAGAAACCTTGC LYM107 ER Xhol (SEQ ID NO: 3763) AATCTCGAGT GAATC ACTCAGTGTGC AT GAC LYM109 XhoI,StuI LYM109 F2 Xhol (SEQ ID NO: 3764) AAACTCGAGCCCAGCGGACTCCTACTCTG LYM109 F2 Xhol (SEQ ID NO: 3764) AAACTCGAGCCCAGCGGACTCCTACTCTG LYM109 R2 StuI (SEQ ID NO: 3765) TTTAGGCCTTCACAGTCTTACAAGTCCGATTGCC LYM109 R2 StuI (SEQ ID NO: 3765) TTTAGGCCTTCACAGTCTTACAAGTCCGATTGCC LYM110 BamHI,XhoI LYM110 NF BamHI (SEQ ID NO: 3766) AAAGGATCCGAACCAAACCTCGGAGAAAC LYM110 NR Xhol (SEQ ID NO: 3767) AAACTCGAGACCATCACCTGTAATACAACTACC LYM111 XhoI,SacI LYM111 NF Xhol (SEQ ID NO: 3768) AAACTCGAGGAATCTGGTTGCTCATCTCATC LYM111 EF Xhol (SEQ ID NO: 3769) AAACTCGAGCTTCACAACGGACGAGAGG LYM111 NR SacI (SEQ ID NO: 3770) AAAGAGCTCATAATCGTTGGAACTTGGAATC LYM111 ER Sad (SEQ ID NO: 3771) AAAGAGCTCACAGCTTATCCCTACATGCTTC LYM112 BamHI,XhoI LYM112 NF BamHI (SEQ ID NO: 3772) AAAGGATCCTCAATTGAATCAGATGCTCCAC LYM112 EF BamHI (SEQ ID NO: 3773) AAAGGATCCATTCCTTTGACCGATTTCTTG 2016213786 11 Aug 2016

156 Gene Name Restriction Enzymes used for cloning Primers used for amplification LYM112 NR Xhol (SEQ ID NO: 3774) AAACTCGAGCTAATTAAGACAAATCAGTGGCACC LYM112 ER Xhol (SEQ ID NO: 3775) AAACTCGAGACAGAAGGTCGATGTTGATCTG LYM113 SalI,XbaI LYM113 NF Sail (SEQ ID NO: 3776) AAAGTCGACTTCTTGATCTAAATTTGGGTGG LYM113 EF Sail (SEQ ID NO: 3777) AAAGT CGAC ACT AGCTCTGCACTTTCCCTG LYM113 NR Xbal (SEQ ID NO: 3778) AAATCTAGAGATTCAAGTGCGTTGTCTGTC LYM113 ER Xbal (SEQ ID NO: 3779) AAATCTAGACTTGGTATTTACAGGACAATCG LYM115 BamHI,XhoI LYM115 F BamHI (SEQ ID NO: 3780) AAAGGATCCTCGCCGCAGATGGAAGTCT LYM115 ER Xhol (SEQ ID NO: 3781) TTTCTCGAGCAAACTCGTCTGGAGATGGG LYM116 SalI,XbaI LYM116 EF Sail (SEQ ID NO: 3782) AAAGTCGACTTGGCTCCGGATATCGCA LYM116 ER Xbal (SEQ ID NO: 3783) AAATCTAGAAGGCAGATGTTCATAACCACAC LYM117 LYM117 F2 BamHI (SEQ ID NO: 3784) AAAGGATCCCGTCGTCAAGTGCTGGC LYM117 R2 EcoRV (SEQ ID NO: 3785) AGTGATATCTCAATGTTTAGGGTCTCGGCATG LYM119 SalI,XbaI LYM119 NF Sail (SEQ ID NO: 3786) AAAGTCGACATCGAGTTGTTCGTCCGTC LYM119 NR Xbal (SEQ ID NO: 3787) AAATCTAGAACACCAAGCGTACATCTCAGAC LYM12 XhoI,KpnI LYM12 EF Xhol (SEQ ID NO: 3788) TT ACTCGAGT GCTTCT CTTCTTTCCTCTCTG LYM12 ER Kpnl (SEQ ID NO: 3789) ATAGGTACCTCACAGCAAACTAACATGAACCG LYM120 BamHI,XhoI LYM120 NF BamHI (SEQ ID NO: 3790) AAAGGATCCGGAAGTCCGGAGTTGGAAG LYM120 NR Xhol (SEQ ID NO: 3791) AAACTCGAGCAGTCACTCACACGCTACTACG LYM121 BamHI,XhoI LYM121 NF BamHI (SEQ ID NO: 3792) AAAGGATCCACTGCTGACCAACTTCAGTGTC LYM121 EF BamHI (SEQ ID NO: 3793) AAAGGAT CCGACAAGGCT ATC AC ATCC AATC LYM121 NR Xhol (SEQ ID NO: 3794) AAACTCGAGTTCT AAAGAAACAATCACGCAC LYM121 ER Xhol (SEQ ID NO: 3795) AAACTCGAGAGCAGAAGAAACTAGGCATGTG LYM122G LYM122 EF BamHI (SEQ ID NO: 3796) AAAGGATCCTGCAGCCCTGACACACAAC LYM122 ER Xhol (SEQ ID NO: 3797) AAACTCGAGACCATCATGTAATACCCACCTC LYM125 LYM125 EF BamHI (SEQ ID NO: 3798) AAAGGATCCCTGTGCTTGGAGTAGACACGAG 2016213786 11 Aug 2016

157 Gene Name Restriction Enzymes used for cloning Primers used for amplification LYM125 ER Kpnl (SEQ ID NO: 3799) AAAGGTACCGGAGAATTTGGATCAGTGCAG LYM127 LYM127 F2 BamHI (SEQ ID NO: 3800) TTTGGATCCCTTCTTGCTGTCGAACACCAG LYM127 R2 Xhol (SEQ ID NO: 3801) TTTCTCGAGGTCATGGGATTCTTGTCAGATACTAG LYM128 BamHI,XhoI LYM128 NF BamHI (SEQ ID NO: 3802) TTT GGAT CCTTC AC ACCTC ACCGAGCG LYM128 EF BamHI (SEQ ID NO: 3803) AAAGGATCCAACCCGTTC AC ACCT C ACC LYM128 NR Xhol (SEQ ID NO: 3804) AAACTCGAGGATCACTTGACAATTACCGTGC LYM128 ER Xhol (SEQ ID NO: 3805) AAACTCGAGTATGCTGATATGCCAGGTTTAC LYM129 SalI,XbaI LYM129 NF Sail (SEQ ID NO: 3806) AAAGTCGACATTCAGTCTTGTCGGCTACATC LYM129 EF Sail (SEQ ID NO: 3807) AAAGTCGACTAGATCAGCCTCGATTCATCTC LYM129 NR Xbal (SEQ ID NO: 3808) AAATCTAGAGCTTAATCAGAAGAAACGAACC LYM129 ER Xbal (SEQ ID NO: 3809) AAATCTAGAAATTGCACAATACATGAACACG LYM13 SalI,BamHI LYM13 NF Sail (SEQ ID NO: 3810) AAAGTCGACCAAGCGGTAGGAGATGAGG LYM13 NR BamHI (SEQ ID NO: 3811) AAAGGATCCTTATAACAACTATTCCCGGTAAGC LYM130 SalI,XbaI LYM13 0_NF_SalI (SEQ ID NO: 3812) AAAGTCGACAGAAATTAAGTTGCCGGAGAG LYM130 NR Xbal (SEQ ID NO: 3813) AAATCTAGAATGCAGATGAGAGCTCAAGATG LYM131 SalI,XhoI LYM131 NF Sail (SEQ ID NO: 3814) AAAGTCGACTCCCTACCCTAGTCGATCTCC LYM131_EF Sail (SEQ ID NO: 3815) AAAGTCGACGACTCGTCTCCTCGTTGCTC LYM131_NF Sail (SEQ ID NO: 3814) AAAGTCGACTCCCTACCCTAGTCGATCTCC LYM131ER Xhol (SEQ ID NO: 3816) AAACTCGAGTATAACACAGGCATAAAGCAGC LYM132 BamHI,XhoI LYM 132_EF_BamHI (SEQ ID NO: 3817) AAAGGATCCATATTGGAATGCTTCTGTCGTC LYM 132 ER Xhol (SEQ ID NO: 3818) AAACT CG AGT ACACGAT AATCAC AAACC ACG LYM134 BamHI,XhoI LYM134 NF BamHI (SEQ ID NO: 3819) AAAGGATCCATGGTGATTCGGTTGTTGTTAG LYM134 EF BamHI (SEQ ID NO: 3820) AAAGGATCCATCGTTGAATTGATGGTGATTC LYM134 NR Xhol (SEQ ID NO: 3821) AAACTCGAGTCATACGTCGAAGAACCAGAAC 2016213786 11 Aug 2016

158 Gene Name Restriction Enzymes used for cloning Primers used for amplification LYM134 ER Xhol (SEQ ID NO: 3822) AAACTCGAGTGAAACTTTCGCCAACTACAC LYM135 LYM135 NF Sail (SEQ ID NO: 3823) AAAGTCGACTTCT GATCT GCTC AGCTAAAGG LYM135 NR SacI (SEQ ID NO: 3824) AAAGAGCTCCTGATGCACAAATATGGTAACG LYM136 BamHI,KpnI LYM136 NF BamHI (SEQ ID NO: 3825) AAAGGATCCCCGGTTCTATGTGTAGGAAGAG LYM136 EF BamHI (SEQ ID NO: 3826) AAAGGATCCCAGGATGAGTGTTGATCCATTC LYM136 NR Kpnl (SEQ ID NO: 3827) AAAGGTACCGTCACAAACGCCTCAACATATC LYM136 ER Kpnl (SEQ ID NO: 3828) AAAGGTACCTT CACC AT ATTGCTACGAAATC LYM137 SalI,XbaI LYM137 NF Sail (SEQ ID NO: 3829) AAAGTCGACAGTTCAAGAGGCTGTCCTGAG LYM137 NR Xbal (SEQ ID NO: 3830) AAATCTAGATCCAATAACATAAGAAACCACG LYM138 Sail,SacI LYM138 EF Sail (SEQ ID NO: 3831) AAAGTCGACAACGAACCACTCTTCTGCATC LYM138 ER SacI (SEQ ID NO: 3832) AAAGAGCT CG A A( iC A ACCT( iG A AAT AAACTC LYM14 EcoRV,PstI LYM14 NF EcoRV (SEQ ID NO: 3833) AAAGATATCCTCCTCAGATCCACCACCAC LYM14 NR PstI (SEQ ID NO: 3834) AATCTGCAGCT AAAATATTCAGGGCTTGTTG LYM140 XhoI,SacI LYM140 F Xhol (SEQ ID NO: 3835) AAACTCGAGCTCCAGCACACGGACGAG LYM140 ER SacI (SEQ ID NO: 3836) AAAGAGCTCTACGAGTACGAATTATTGCCAG LYM141 LYM141 NF BamHI (SEQ ID NO: 3837) AAAGGATCCACAAGCGTCTTCTTCGTCTTC LYM141 NR Kpnl (SEQ ID NO: 3838) AAAGGTACCCCATGCCACCCTTACTATACTC LYM142 Sail,SacI LYM142 NF SalB (SEQ ID NO: 3839) TAAGTCGACCACACAGAGCACAGCACAGAG LYM142 NR SacB (SEQ ID NO: 3840) TGAGCTCTGAACATGCGACCGTATGC LYM143 Sail,Xbal LYM143 NF Sail (SEQ ID NO: 3841) AAAGTCGACCACTAGCGCACAGATCTCCTAC LYM143 NR Xbal (SEQ ID NO: 3842) AAATCTAGAAATAGTGTCCATGAGACGAACG LYM144 SalI,EcoRV LYM144 NF Sail (SEQ ID NO: 3843) AAAGTCGACACGACGAGGAGGAGGATG LYM144 NR EcoRV (SEQ ID NO: 3844) AATGATATCACGCATGGATTTCTTTAAGTTG LYM145 BamHI,XhoI LYM145 F2 BamHI (SEQ ID NO: 3845) ATCGGATCCTAGCTTTGCCCAGTTTTGCT 2016213786 11 Aug 2016

159 Gene Name Restriction Enzymes used for cloning Primers used for amplification LYM145_F2_BamHI (SEQ ID NO: 3845) AT CGG ATCCT AGCTTT GCCC AGTTTTGCT LYM 145 R2 Xhol (SEQ ID NO: 3846) TTTCTCGAGCTATGCAGTTTTAGCCTAAGGCAAG LYM 145 R2 Xhol (SEQ ID NO: 3846) TTTCTCGAGCTATGCAGTTTTAGCCTAAGGCAAG LYM146 LYM146 F2 Kpnl (SEQ ID NO: 3847) AAAGGTACCCGAGGTCGTCACGCACAG LYM 146 R2 Kpnl (SEQ ID NO: 3848) AATGGTACCTGGGTGGTTAGACAGCAAGG LYM147 SalI,XbaI LYM 147 NF Sail (SEQ ID NO: 3849) AAAGTCGACCTCTGGCGCTCTCCTATACTC LYM147 EF Sail (SEQ ID NO: 3850) AAAGTCGACAGTACGTGTACGTTTCAGGGAG LYM 147 NR Xbal (SEQ ID NO: 3851) AAATCTAGAAGTACCACTAGCAGAAAGGCAG LYM 147 ER Xbal (SEQ ID NO: 3852) AAATCTAGATGGCACCCAATACTAGTACCAC LYM148 BamHI,XhoI LYM148 NF BamHI (SEQ ID NO: 3853) AAAGGATCCCTTACCCTTCCCTGAGATCC LYM148 NR Xhol (SEQ ID NO: 3854) AAACTCGAGCTAACTACCAAAGTTCAAGCAGCTC LYM149 SalI,XbaI LYM 149 NF Sail (SEQ ID NO: 3855) AAAGTCGACACCATGAGTTCATAACAAGAAGG LYM 149_NR_XbaI (SEQ ID NO: 3856) AAATCTAGACTAATACATGGAAGTGCAGACATGC LYM15 SalI,XbaI LYM 15 NF Sail (SEQ ID NO: 3857) AAAGTCGACAGGTACAGTATAGTATGACACCGAC LYM 15 NR Xbal (SEQ ID NO: 3858) AATTCTAGACTACTGTTAACCGCTGATTATATCC LYM152 SalI,XbaI LYM 152 NF Sail (SEQ ID NO: 3859) TTTGTCGACGAAGAAGAGATGGGAGTTTTCTC LYM 152 NR Xbal (SEQ ID NO: 3860) AAATCTAGAATTTCTGACATTACATTATAGTCTCG LYM153 SalI,XbaI LYM153 NF Sail (SEQ ID NO: 3861) AAAGTCGACTTCTCCTCCTACGTTCTACTGG LYM 153 NR Xbal (SEQ ID NO: 3862) AAATCTAGACT AAC AGGGTTTCTCCACT AAGT AAG LYM155 SalI,XbaI LYM155 NF Sail (SEQ ID NO: 3863) AAAGTCGACTCCACTATAAGCAACGCACC LYM155 EF Sail (SEQ ID NO: 3864) AAAGTCGACGAAGGAAACTCGGTGACACG LYM 155 NR Xbal (SEQ ID NO: 3865) AAATCTAGAATGCCATGCTACTAAGAACCTAC LYM155 ER Xbal (SEQ ID NO: 3866) AAATCTAGATAAACATCTCATGCCATGCTAC LYM156 StuI,StuI LYM156 NF StuI (SEQ ID NO: 3867) TTTAGGCCTCAAGATCCGCAGAGATGATC LYM 156 NR StuI 2 (SEQ ID NO: 3868) AAAAGGCCTTTAAGTGCTTGCGTCGTTTTACAG 2016213786 11 Aug 2016

160 Gene Name Restriction Enzymes used for cloning Primers used for amplification LYM157_G XbaI,SacI LYM157 EF Xba B (SEQ ID NO: 3869) AAT CT AGACCTCGAGCC ACCC ACTTTC LYM157 ER Sac B (SEQ ID NO: 3870) TGAGCTCTCACCTTCATCTTGTCTTCACTGGT LYM159 SalI,XbaI LYM159 NF Sail (SEQ ID NO: 3871) AAAGTCGACCTCTACCTTCTTCTTCGGTCAG LYM159 NR Xbal (SEQ ID NO: 3872) AAATCTAGAAGCTTAGCTAGGCCAACAATAC LYM16 SalI,XbaI LYM16 NF Sail (SEQ ID NO: 3873) CTAGTCGACAAGAAATTGGCACAGAAATGG LYM16 NR Xbal (SEQ ID NO: 3874) TATTCTAGATCAAAGAGCCTAGTGAGCGTCTTC LYM160 SalI,XbaI LYM160 F2 Sail (SEQ ID NO: 3875) AAAGTCGACAGGCCAGACCAAAACCATG LYM160 F2 Sail (SEQ ID NO: 3875) AAAGTCGACAGGCCAGACCAAAACCATG LYM160 NR Xbal (SEQ ID NO: 3876) AAATCTAGAAGAGTAACATGGACACACGACC LYM160 R2 Xbal (SEQ ID NO: 3877) AATTCTAGATCAGTACAAGAGCCAGATGTCTGA LYM161 BamHI,XhoI LYM161 EF BamHI (SEQ ID NO: 3878) AAAGGATCCGAGAGAGGAGCAAAGATTCACC LYM161 ER Xhol (SEQ ID NO: 3879) AAACTCGAGTACAGGATGGTTGGTCTTCTTC LYM162 BamHI,XhoI LYM162 NF BamHI (SEQ ID NO: 3880) TTTGGATCCGCATCTAAGCCGAATTGAAG LYM162 NR Xhol (SEQ ID NO: 3881) AAACTCGAGCTATTTCATGCTCAGTACCTGCAC LYM164 SalI,XbaI LYM164 NF Sail (SEQ ID NO: 3882) AAAGTCGACATCCAGATGCTTCACATTCTTG LYM164 NR Xbal (SEQ ID NO: 3883) AAATCTAGATCGAGTTTGACACGAACTTATG LYM165 LYM165 F2 Xhol (SEQ ID NO: 3884) AAACTCGAGCTACTCCGATCGGATCCTGAC LYM165 R2 SacI (SEQ ID NO: 3885) AAAGAGCTCAAACGACGCACGGTCTCAC LYM17 SmaI,KpnI LYM17 NF X/Smal (SEQ ID NO: 3886) AT ACCCGGGTCTCT C AAGATGGT GGTGCT G LYM17 NR Kpnl (SEQ ID NO: 3887) TATGGTACCAAGGGCTTAGCAAATTCTTTC LYM170 SalI,XbaI LYM170 NF Sail (SEQ ID NO: 3888) AAAGTCGACATTCTTCGACCTCCTAAACTCC LYM170 EF Sail (SEQ ID NO: 3889) AAAGTCGACAGTCTCACACAGATCGCTTCAC LYM170 NR Xbal (SEQ ID NO: 3890) AAATCTAGACTACCAACTCAGAACCAGGATGAG LYM170 ER Xbal (SEQ ID NO: 3891) AAATCTAGACATACCTATAAGGCTATAACACTGC LYM172 BamHI,XhoI LYM172 NF BamHI (SEQ ID NO: 3892) AAAGGATCCCTCGTCTTCGTCTACTCCACC 2016213786 11 Aug 2016

161 Gene Name Restriction Enzymes used for cloning Primers used for amplification LYM172 EF BamHI (SEQ ID NO: 3893) AAAGGATCCCCTCACTCGTAGTCTCGTCTTC LYM172 NR Xhol (SEQ ID NO: 3894) AAACTCGAGGGAGCTTTGGAGAATAACAAAC LYM172 ER Xhol (SEQ ID NO: 3895) AAACT CGAGCAACAGGTAACTC ATTT CC ACC LYM173 BamHI,XhoI LYM173 NF BamHI (SEQ ID NO: 3896) AAAGGATCCTCATCAGTTCCCTGTTCTTCAG LYM173 NR Xhol (SEQ ID NO: 3897) AAACTCGAGATGACTGGACTAAAGCAACCAC LYM174 BamHI,KpnI LYM174 NF BamHI (SEQ ID NO: 3898) AAAGGATCCCTCTTGCTAGGAGTAGCCTGC LYM174 NR Kpnl (SEQ ID NO: 3899) AAAGGTACCTATTATCCTACATGCCACATGC LYM175 SalI,XbaI LYM175 NF Sail (SEQ ID NO: 3900) AAAGTCGACCACTCCCTCTTATAGCCCACC LYM175 NR Xbal (SEQ ID NO: 3901) AAATCTAGACTAAGTGTACAGTTCACGGCACG LYM176 SalI,XbaI LYM176 NF Sail (SEQ ID NO: 3902) AAAGTCGACTCTCGTTTCTCCTACCCTACAG LYM176 NR Xbal (SEQ ID NO: 3903) AAATCTAGACTAACAGTTTCCAGTCAAAGCTACAG LYM178 SalI,XbaI LYM178 NF Sail (SEQ ID NO: 3904) AAAGTCGACCTATCCATCCGCCACAAGAC LYM178 NR Xbal (SEQ ID NO: 3905) AAATCTAGAACACAAGACACCATTTCTGGAG LYM179 SalI,XhoI LYM179 NF Sail (SEQ ID NO: 3906) AAAGT CGACAGGATTTCTCT AGGATAGCAGC LYM179 EF Sail (SEQ ID NO: 3907) AAAGTCGACCTCAGTCGAGCGAGGATTTC LYM179 NR Xhol (SEQ ID NO: 3908) AAACTCGAGAAACAGAGCCTAACAGACATGG LYM179 ER Xhol (SEQ ID NO: 3909) AAACTCGAGGGGATGTTTAGACTGCTACAGG LYM180 BamHI,XhoI LYM180 NF BamHI (SEQ ID NO: 3910) TATGGATCCCGACCTTTGATACCAAGCAAG LYM180 NR Xhol (SEQ ID NO: 3911) TTACTCGAGCACGGATTAGTTTGTAGTAGCATGG LYM181 LYM181 F2 BamHI (SEQ ID NO: 3912) AATGGATCCTAAAAATGGCGGCTGCTACTC LYM181 R2 EcoRV (SEQ ID NO: 3913) TTTGATATCTCATACACGGTTTCATATGGTCGG LYM183 LYM183 EF Sail (SEQ ID NO: 3914) AAAGTCGACATCAAACCAACGAGAGCACTAC LYM183 ER Xbal (SEQ ID NO: 3915) AAATCTAGAACTTCAGTGTACTTTCCCTTGC LYM184 LYM184 NF BamHI (SEQ ID NO: 3916) AAAGGATCCAACACGACTTGTGAGTGAGAGC LYM184 EF BamHI (SEQ ID NO: 3917) AAAGGATCCATATGAGTAACGCCATCAGGAG 2016213786 11 Aug 2016

162 Gene Name Restriction Enzymes used for cloning Primers used for amplification LYM184 NR Xhol (SEQ ID NO: 3918) AAACTCGAGT GCCTCATTTAATCTT GGGTC LYM184 ER Xhol (SEQ ID NO: 3919) AAACTCGAGGAAATTGCCTCATTTAATCTTG LYM185 BamHI,KpnI LYM185_NF_BamHI (SEQ ID NO: 3920) AAAGGATCCAATTCGAGATATTTGGCTGTTC LYM 185 EF BamHI (SEQ ID NO: 3921) AAAGGATCCAGATAGCAAGATAGTCCGGTTG LYM 185 NR Kpnl (SEQ ID NO: 3922) AAAGGT ACCGGTCTAT CACAAGCATCCTCAC LYM 185 ER Kpnl (SEQ ID NO: 3923) AAAGGTACCACCACCTTTGTGATTGTTTCTC LYM186 SalI,XbaI LYM 186 NF Sail (SEQ ID NO: 3924) AAAGTCGACCGACCCAAATTGACATAACTC LYM 186 NR Xbal (SEQ ID NO: 3925) AAATCTAGAATAGCTGGAACCTGGTATTGAC LYM188 BamHI,XhoI LYM 188 EF BamHI (SEQ ID NO: 3926) AAAGGAT CCCGAGCT AGGGTT AGGGTTTC LYM 188 ER Xhol (SEQ ID NO: 3927) AAACTCGAGCAACAACTCACGCTACACATTC LYM189 SalI,XbaI LYM 189 NF Sail (SEQ ID NO: 3928) AAAGTCGACCCACGTCCTAGAATGAAAGAG LYM189_EF Sail (SEQ ID NO: 3929) AAAGTCGACTTCCTCTGCTTCCCACAGC LYM189 NR Xbal (SEQ ID NO: 3930) AAATCTAGACTGTTCATTCACGGTTGCAC LYM 189 ER Xbal (SEQ ID NO: 3931) AAATCTAGAGCAAATCTGTCGCTTTATTAGG LYM19 SalI,XbaI LYM19 NF Sail (SEQ ID NO: 3932) AAAGTCGACGAGAGAAGAGAGATGGTCCTCC LYM19 NR Xbal (SEQ ID NO: 3933) AAATCTAGATTATCATGCTGACTTCTTGCCAC LYM192 XhoI,EcoRV LYM 192 EF Xhol (SEQ ID NO: 3934) AAACTCGAGTGAGCAGCGAGCCCTAAC LYM 192 R EcoRV (SEQ ID NO: 3935) TTTGATATCTCACACTACTAGGGAGTGGAGTAGTAA CTTGA LYM193 BamHI,XhoI LYM 193 NF BamHI (SEQ ID NO: 3936) AAAGGATCCCTAGTAGTGTTCTTCCCATTCG LYM 193 EF BamHI (SEQ ID NO: 3937) AAAGGATCCAACAATCCGTCCTTTCATTTG LYM193 NR Xhol (SEQ ID NO: 3938) AAACTCGAGTAAACGACAGCGGTACACATAC LYM 193 ER Xhol (SEQ ID NO: 3939) AAACTCGAGT ACATCTCT AGGCAGCAAACAG LYM196 LYM 196 NF BamHI (SEQ ID NO: 3940) AAAGGATCCGAGGACACCGCTTGCTTTC LYM 196 NR Xhol (SEQ ID NO: 3941) AAACTCGAGAACCTTGGATATGACCAATCAG LYM197 BamHI,XhoI LYM 197 EF BamHI (SEQ ID NO: 3942) AAAGGATCCCTGTTGCCACATCTAGTGGTTC 2016213786 11 Aug 2016

163 Gene Name Restriction Enzymes used for cloning Primers used for amplification LYM197 ER Xhol (SEQ ID NO: 3943) AAACTCGAGCACAATTCAGCGATTATTTCAG LYM198 BamHI,XhoI LYM198 F2 BamHI (SEQ ID NO: 3944) ATTGGATCCTTCATTTCCGCCATCCGT LYM198 R2 Xhol (SEQ ID NO: 3945) AAACTCGAGCACCATCTCTTGCAGAAGGC LYM2 EcoRV,KpnI LYM2 NF EcoRV (SEQ ID NO: 3946) AAAGATATCCGGTAGGTAGATGAAATTAAGG LYM2 NR Kpnl (SEQ ID NO: 3947) CGAGGTACCCTAATATGCAGGTCAGCACACAAG LYM20 EcoRV,KpnI LYM20 NF EcoRV (SEQ ID NO: 3948) ATAGATATCACTCCGAATCCGACGCAC LYM20 EF EcoRV (SEQ ID NO: 3949) ATAGATATCGAGATCCCAACTCCGAATCC LYM20 NR Kpnl (SEQ ID NO: 3950) TATGGTACCCTACGTAAATCTCAGCACATGC LYM20 ER Kpnl (SEQ ID NO: 3951) TATGGTACCCTTCTGCAACGTTATTTGAGG LYM200 BamHI,Xhol LYM200 NF BamHI (SEQ ID NO: 3952) AAAGGATCCACTTTACCGGGCTACCATTC LYM200 EF BamHI (SEQ ID NO: 3953) AAAGGATCCTTACAAGAGCCTGTGAGCTGAG LYM200 NR Xhol (SEQ ID NO: 3954) AAACTCGAGCTTATCTGGACCACACTTGGAC LYM200 ER Xhol (SEQ ID NO: 3955) AAACTCGAGAAGAAATACATAGCCCTCCTCC LYM201 BamHI,XhoI LYM201 NF BamHI (SEQ ID NO: 3956) AAAGGATCCGCCTCATCTCGGTTTACTATAAG LYM201 NR Xhol (SEQ ID NO: 3957) AAACTCGAGAAGTAGACACAAACCATCCTGG LYM203 BamHI,XhoI LYM203 EF BamHI (SEQ ID NO: 3958) AAAGGATCCTCTATCAAATCAGCCACCTGTC LYM203 ER Xhol (SEQ ID NO: 3959) AAACTCGAGCTAGCAACTTTGTAGACCAGACGTG LYM204 LYM204 NF BamHI (SEQ ID NO: 3960) AAAGGATCCCTACTACCAGACAGAGAGGACAGG LYM204 EF BamHI (SEQ ID NO: 3961) TTTGGATCCGCTTTCTGGCATCGCTACTAC LYM204 NR Xhol (SEQ ID NO: 3962) TGTCTCGAGTCAGTAGGAGTTTATGAGATGAACC LYM204 ER Xho (SEQ ID NO: 3963) AAACTCGAGTCAACTCATCATCCGGAACATGGTAC LYM206 XhoI,EcoRV LYM206 EF Xhol (SEQ ID NO: 3964) AAACTCGAGAATTCTAGCAAGGCAGCTCAG LYM206 ER EcoRV (SEQ ID NO: 4199) AAAGATATCTAAAGGAGTCGTAGCCCTCTC LYM207 LYM207 EF BamHI (SEQ ID NO: 3966) AAAGGATCCACTCTTCCAACCGCTCCTC LYM207 ER Kpnl (SEQ ID NO: 4200) AAAGGTACCCTAGTCTTGCGAAGTGCGAG LYM208 BamHI,XhoI LYM208 F2 BamHI (SEQ ID NO: 3968) AAAGGATCCTGCGGCTGAGTACAGACGAC 2016213786 11 Aug 2016

164 Gene Name Restriction Enzymes used for cloning Primers used for amplification LYM208 R2 Kpnl (SEQ ID NO: 3969) AAAGGT ACCC AT C AATCC ATGCT AATGT AGAGC LYM21 EcoRV,KpnI LYM21 NF EcoRV (SEQ ID NO: 3970) AAAGATATCTCTCGCAGCACAAAGATGG LYM21 NR Kpnl (SEQ ID NO: 3971) ATAGGTACCTCACCCTTAGTTCTTCACAGTGGTG LYM212 SalI,XbaI LYM212 NF Sail (SEQ ID NO: 3972) AAAGTCGACCTGATACCCATCCATCCACC LYM212 EF Sail (SEQ ID NO: 3973) AAAGTCGACACTGACAAACCGGACCCAC LYM212 NR Xbal (SEQ ID NO: 3974) AAATCTAGACTAGCAGAGCCGAAGTAGTACGAG LYM212 ER Xbal (SEQ ID NO: 3975) AAAT CTAGACT AGAACGAAGT AGTACGAGC AAGC LYM213 BamHI,XhoI LYM213 EF BamHI (SEQ ID NO: 3976) AAAGGATCCCAGCTCATCAGAACACAGAAGG LYM213 ER Xhol (SEQ ID NO: 3977) AAACTCGAGTTCGACAATTTGCAATAGAAAG LYM215 BamHI,XhoI LYM215 F2 BamHI (SEQ ID NO: 3978) AATGGATCCTTCCCTCCCACCGAAATG LYM215 F2 BamHI (SEQ ID NO: 3978) AATGGATCCTTCCCTCCCACCGAAATG LYM215 R2 Xhol (SEQ ID NO: 3979) AAACTCGAGGAGCATGCAAAATGGACTAGACT LYM215 R2 Xhol (SEQ ID NO: 3979) AAACTCGAGGAGCATGCAAAATGGACTAGACT LYM217 SalI,XbaI LYM217 F2 Sail (SEQ IDNO:4201 ) AAAGTCGACCGACCGATCCAAGTAGTGAGC LYM217 R2 Xbal (SEQ ID NO:4202 ) AAATCTAGAAGCTGATAGGCCAGTCAATCC LYM219 BamHI,KpnI LYM219 F BamHI (SEQ ID NO: 3980) AAAGGATCCTAGCAGTCTCGATGGCCG LYM219 F BamHI (SEQ ID NO: 3980) AAAGGATCCTAGCAGTCTCGATGGCCG LYM219 R Kpnl (SEQ ID NO: 3981) TTTGGTACCCGAGTCAGCTTTTGTAATGATAG LYM219 R Kpnl (SEQ ID NO: 3981) TTTGGTACCCGAGTCAGCTTTTGTAATGATAG LYM22 SalI,XbaI LYM22 NF Sail (SEQ ID NO: 3982) AAAGTCGACTTAGCACACATGGCGTCTTC LYM22 EF Sail (SEQ ID NO: 3983) AAAGTCGACCATCGGCATCTTCCTAACTG LYM22 NR Xbal (SEQ ID NO: 3984) AATTCTAGATAATCTGTAGATGGCTGCCG LYM22 ER Smal (SEQ ID NO: 3985) AATCCCGGGTAACAACGTACATGCAAGTCATC LYM220 BamHI,EcoRV LYM220 NF BamHI (SEQ ID NO: 3986) AAAGGATCCCGACTTCAAGCATCAGACTACC 2016213786 11 Aug 2016

165 Gene Name Restriction Enzymes used for cloning Primers used for amplification LYM220 EF BamHI (SEQ ID NO: 3987) AAAGGAT CC AGCAC AC AC ATCCTCTAAGTGC LYM220 NR EcoRV (SEQ ID NO: 3988) AAAGATATCAACAGCAGTCACTTCACTCGTC LYM220 ER EcoRV (SEQ ID NO: 3989) AAAGATATCAAGTGGTACGGCTGAGTGTAAC LYM221 BamHI,XhoI LYM221 NF BamHI (SEQ ID NO: 3990) AAAGGAT CC ACT GTCC ACTGCGTCT GTCTC LYM221 EF BamHI (SEQ ID NO: 3991) AAAGGATCCATCGTTAGAGGCTCAGAGTCAG LYM221 NR Xhol (SEQ ID NO: 3992) AAACTCGAGACTACGTATTACACGGAGGTGG LYM221 ER Xhol (SEQ ID NO: 3993) AAACTCGAGTCTGCAGCATTCCTTAACCTAC LYM223 XhoI,SacI LYM223 NF Xhol (SEQ ID NO: 3994) AAACTCGAGACCTGCCTGCCACTATACTATC LYM223 EF Xhol (SEQ ID NO: 3995) AAACT CGAGAGACCCGTCTTAACTCT ACCT G LYM223 NR SacI (SEQ ID NO: 3996) AAAGAGCTCAGCACCGGTTGATCTAGAATAC LYM223 ER SacI (SEQ ID NO: 3997) AAAGAGCTCATTTATCCACGAACCCATATTC LYM224 BamHI,XhoI LYM224 EF BamHI (SEQ ID NO: 3998) AAAGGATCCCAGGCCTCACGTGTCATTC LYM224 EF BamHI (SEQ ID NO: 3998) AAAGGATCCCAGGCCTCACGTGTCATTC LYM224 R2 Xhol (SEQ ID NO: 3999) AAACTCGAGGTTT CC AGCC AACCAGAAC AC LYM224 ER Xhol (SEQ ID NO: 4000) AAACTCGAGGATCCAAATTGGTAATGCTTTG LYM228 LYM228 NF BamHI (SEQ ID NO: 4001) AAAGGATCCGCAAGCACTCCACTTCAAGC LYM228 F2 BamHI (SEQ ID NO: 4002) AAAGGATCCCTCGAAGTGTCCAAGAAGAACACA LYM228 R2 Kpnl (SEQ ID NO: 4003) TAAGGTACCGAGCTGCAAACATAACGTCGAG LYM228 R2 Kpnl (SEQ ID NO: 4003) TAAGGTACCGAGCTGCAAACATAACGTCGAG LYM23 BamHI,KpnI LYM23 NF BamHI (SEQ ID NO: 4004) AAAGGATCCTCATCTCTCTCCCTCTCATCG LYM23 NR Kpnl (SEQ ID NO: 4005) AAAGGTACCGTGCTGCTTCAACTATCCTCTC LYM232 LYM232 EF BamHI (SEQ ID NO: 4006) AAAGGATCCAAATT CCC AATTTCTTCGGT C LYM232 ER Xhol (SEQ ID NO: 4007) AAACTCGAGAGC AC ACAC AGGTT CCT AAGAG LYM236 SalI,XbaI LYM236 F Sail (SEQ ID NO: 4008) AAAGTCGACGACTACCAATCCAATCTCCTCC LYM236 ER Xbal (SEQ ID NO: 4009) AAATCTAGAAGAAATGTATAATCGAAGTGCATC LYM238 LYM238 EF Smal (SEQ ID NO: 4010) AAACCCGGGT AGTGGT GGAGAGACGAAAC AC 2016213786 11 Aug 2016

166 Gene Name Restriction Enzymes used for cloning Primers used for amplification LYM238 ER SacI (SEQ ID NO: 4011) AAAGAGCTCCTACAAGTGCTGACTGCTGAAG LYM239 BamHI,XhoI LYM239 EF BamHI (SEQ ID NO: 4012) AAAGGATCCCTTGGTCCGTCTCCACTCTC LYM239 R Xhol (SEQ ID NO: 4013) AAACTCGAGCT AGGATTGGTACTCATTTCTTT GT G LYM24 SalI,XbaI LYM24 NF Sail (SEQ ID NO: 4014) AACGT CGACTCTT CTCTTTCTCTTCTCCTCG LYM24 NR Xbal (SEQ ID NO: 4015) ATATCTAGACATTCCAAACATTGTTATCAAAC LYM240 BamHI,KpnI LYM240 NF BamHI (SEQ ID NO: 4016) AAAGGATCCTACTGTAAGCAGTTTCCCACC LYM240 EF BamHI (SEQ ID NO: 4017) AAAGGATCCAACAACGCTCGTACTGTAAGC LYM240 NR Kpnl (SEQ ID NO: 4018) AAAGGTACCACAAGTCATTCTACCAAGCACC LYM240 ER Kpnl (SEQ ID NO: 4019) AAAGGTACCATACTTTCCTTGCTCTGCTGTC LYM241 LYM241 NF BamHI (SEQ ID NO: 4020) AAAGGATCCAAACGGTTGGGAGGTTAGC LYM241 NR Xhol (SEQ ID NO: 4021) AAACTCGAGACTGGATCAGATTGTGAAGGTG LYM242 BamHI,XhoI LYM242 NF BamHI (SEQ ID NO: 4022) AAAGGATCCACGACTCCGACGAGCGAC LYM242 NR Xhol (SEQ ID NO: 4023) AAACTCGAGAACTCAAGTGGACAAATGTTGC LYM243 BamHI,XhoI LYM243 EF BamHI (SEQ ID NO: 4024) AAAGGATCCAGAAGCGTAGAGCGGTCAAG LYM243 ER Xhol (SEQ ID NO: 4025) AAACTCGAGCATTAAGCGAATTAACCATGTG LYM245 BamHI,KpnI LYM245 F BamHI (SEQ ID NO: 4026) AAAGGATCCGCTAGCTACTAGCAAATTGAAGC LYM245 F BamHI (SEQ ID NO: 4026) AAAGGATCCGCTAGCTACTAGCAAATTGAAGC LYM245 NR Kpnl (SEQ ID NO: 4027) AAAGGTACCGGTCACCCGTTAGACTTATGC LYM245_ER Kpnl (SEQ ID NO: 4028) AAAGGTACCTGGTAAATTATGGGTATTCAGC LYM248 BamHI,EcoRV LYM248 F BamHI (SEQ ID NO: 4029) AAAGGATCCACCACCGCTCGTCTCCAC LYM248_NR EcoRV (SEQ ID NO: 4030) AAAGATATCACAAGAGAGATGGTGTGTCAGC LYM249 LYM249 EF BamHI (SEQ ID NO: 4031) AAAGGATCCGGGTGTCATCAAACGGACTAC LYM249 ER Kpnl (SEQ ID NO: 4032) AAAGGTACCCTAAACGAGGTTACGGAATGTGTC LYM250 SalI,XbaI LYM250 EF Sail (SEQ ID NO: 4033) AAAGTCGACGGAATTGGTGAGGTGATGC LYM250_ER Xbal (SEQ ID NO: 4034) AAATCTAGACAGATAAACCTCAATCAAAGTCG LYM251 LYM251 NF Sail (SEQ ID NO: 4035) AAAGTCGACCTGT CCT CTACTACGC AT CTCTC 2016213786 11 Aug 2016

167 Gene Name Restriction Enzymes used for cloning Primers used for amplification LYM251 NR Xbal (SEQ ID NO: 4036) AAATCTAGATAATCATCATTGTAGCAGGCAC LYM252 BamHI,KpnI LYM252 NF BamHI (SEQ ID NO: 4037) AAAGGATCCTAGGAAGGATGGTACTGGCTG LYM252 EF BamHI (SEQ ID NO: 4038) AAAGGAT CCGCGAT AGGAAGGATGGT ACTG LYM252 NR Kpnl (SEQ ID NO: 4039) AAAGGTACCAGGCAAACACAATGATTTCAAC LYM252 ER Kpnl (SEQ ID NO: 4040) AAAGGTACCTGTAACATAAGTACCGGGCAG LYM254 LYM254 EF Sail (SEQ ID NO: 4041) AAAGTCGACAATCTCCCACGCTCCAAAG LYM254 ER Xbal (SEQ ID NO: 4042) AAATCTAGAAGTTACATTCTTGACCAGCAGC LYM255 BamHI,XhoI LYM255 NF BamHI (SEQ ID NO: 4043) AAAGGATCCCTTCTAGTAGCACAGTAGTAGCAGC LYM255 NR Xhol (SEQ ID NO: 4044) AAACTCGAGAACGAGGAAGAATCGGTATATG LYM256 BamHI,Xhol LYM256 NF BamHI (SEQ ID NO: 4045) AAAGGATCCGGAACAACTCGTAGCCATGAC LYM256 EF BamHI (SEQ ID NO: 4046) TATGGATCCCAATTTGAGAGCATTTGCTACG LYM256 NR Xhol (SEQ ID NO: 4047) TAACTCGAGCTGAACTTAATAGCAATTCCGTAGC LYM256 ER Xhol (SEQ ID NO: 4048) AAACTCGAGCGCACTACTGTGCTTCTGAAC LYM26 SalI,XbaI LYM26 EF Sail (SEQ ID NO: 4049) AAAGTCGACTTGCTCCCTCTCTCTCTCTTG LYM26 ER Xbal (SEQ ID NO: 4050) AAATCTAGATGT ATT C ACGAGGTAAACAACG LYM260 LYM260 NF BamHI (SEQ ID NO: 4051) AAAGGATCCGAGAGATTAATTAAGTGGCAGG LYM260 EF BamHI (SEQ ID NO: 4052) AAAGGATCCAGAAGAGAGATTAATTAAGTGGCAG LYM260 NR Kpnl (SEQ ID NO: 4053) AAAGGTACCCTAATATCGATCCAAACTCACACAAG LYM260 ER Kpnl (SEQ ID NO: 3965) AAAGGT ACCT ACGTGCGT ATC AT ACATGGAG LYM261 LYM261 EF Smal (SEQ ID NO: 4054) AATCCCGGGTCGAGAGGTTTCATTCAGTGC LYM261 ER Kpnl (SEQ ID NO: 4055) TTTGGTACCTTATTACATTTGGATGGGCTGT LYM267 SalI,EcoRV LYM267 F Sail (SEQ ID NO: 4056) AAAGTCGACGAGCACAGGTAGGGTTTCG LYM267 ER EcoRV (SEQ ID NO: 4057) AAAGATATCCACTACCGAAGACTCACACGAC LYM268 LYM268 EF Xhol (SEQ ID NO: 4058) AAACTCGAGAACCCTCGCGAATCTGAG LYM268 ER EcoRV (SEQ ID NO: 4059) AAAGATATCTAGTTCTCCATTCAGCATCTCC LYM270 BamHI,XhoI LYM270 NF BamHI (SEQ ID NO: 4060) AAAGGAT CC AAAGCAGTTCC AGCCTT CC 2016213786 11 Aug 2016

168 Gene Name Restriction Enzymes used for cloning Primers used for amplification LYM270 EF BamHI (SEQ ID NO: 4061) AAAGGATCCACCAATGGCTGCCTGAGAC LYM270 NF BamHI (SEQ ID NO: 4060) AAAGGATCCAAAGCAGTTCCAGCCTTCC LYM270 ER Xhol (SEQ ID NO: 4062) AAACTCGAGGATTGGAT ATGCC ACTT GATT G LYM271 BamHI,XhoI LYM271 EF BamHI (SEQ ID NO: 4063) AAAGGATCCCACCTTCTTCCCAGATCAATAG LYM271 ER Xhol (SEQ ID NO: 4064) AAACTCGAGGAAACAAAGCACAGTCAGTAGTAG LYM273_S BamHI,XhoI LYM273 EF BamHI (SEQ ID NO: 4065) AAAGGATCCTACTAACAAACAGATAATCTCCACG LYM273 R2 Xhol (SEQ ID NO: 4066) ATACTCGAGAACATGTTGGAGATCTTTGATGC LYM274 BamHI,XhoI LYM274 EF BamHI (SEQ ID NO: 4067) AAAGGATCCGAGAAGCTCCACTCTTCTCCAC LYM274 ER Xhol (SEQ ID NO: 4068) AAACTCGAGT AT AATGC AC AGTT ATGGGCAG LYM277 LYM277 NF Sail (SEQ ID NO: 4069) AAAGTCGACT C AACGCCC AAGCTAG ATT AC LYM277 NR Sad (SEQ ID NO: 4070) AAAGAGCTCCTCAACATTGCAACAACTATGG LYM278 Sail,SacI LYM278 EF Sail (SEQ ID NO: 4071) AAAGTCGACGCAGCCACACAACACTATCTC LYM278 ER Sad (SEQ ID NO: 4072) AAAGAGCTCTTGACGATACATAGCACATAAGG LYM283 LYM283 NF Smal (SEQ ID NO: 4073) TTTCCCGGGT GCCACTTGT GCGAGGAG LYM283 R Kpnl (SEQ ID NO: 4074) AACGGTACCTCACCAATCAAAATGTACAATCATGT LYM284 BamHI,KpnI LYM284 EF BamHI (SEQ ID NO: 4075) AAAGGATCCGAGC AACCACCCGT AGTC AG LYM284 ER Kpnl (SEQ ID NO: 4076) AAAGGTACCACAGCTCAAGTGCTCATTTCTC LYM285 XhoI,EcoRV LYM285 NF Xhol (SEQ ID NO: 4077) AAACTCGAGCCGCCATCTACTCGGAGC LYM285 EF Xhol (SEQ ID NO: 4078) AAACTCGAGCCTCCTCCGCCATCTACTC LYM285 NR EcoRV (SEQ ID NO: 4079) AAAGATATCAGAATTCACACTGTCCCAACAC LYM285 ER EcoRV (SEQ ID NO: 4080) AAAGATATCCAGTTATTATAGGCCTCGTTCC LYM287 XhoI,EcoRV LYM287 EF Xhol (SEQ ID NO: 4081) AAACTCGAGTGATTGCGTTTCCTTAAATATG LYM287 ER EcoRV (SEQ ID NO: 4082) AAAGATATCCAATCAATCCTACAAACACAGC LYM288 XhoI,SacI LYM288 EF Xhol (SEQ ID NO: 4083) AAACTCGAGTGTTAGGAAGTGAGGACTGAGC LYM288 ER SacI (SEQ ID NO: 4084) AAAGAGCTCGCTCAATTATTCACCATTTCATC LYM289 SalI,XbaI LYM289 EF Sail (SEQ ID NO: 4085) AAAGTCGACGCACAACCCTTGGAGACTTC 2016213786 11 Aug 2016

169 Gene Name Restriction Enzymes used for cloning Primers used for amplification LYM289 ER Xbal (SEQ ID NO: 4086) AAATCTAGATCCTCTCATCGAGCTAAGACAC LYM290 BamHI,KpnI LYM290 EF BamHI (SEQ ID NO: 4087) AAAGGATCCATCCGGATCTCCACATTCC LYM290 ER Kpnl (SEQ ID NO: 4088) AAAGGTACCGAAACAATCTCATGGTCTCTGC LYM291 SalI,BamHI LYM291 EF Sail (SEQ ID NO: 4089) AAAGTCGACACTGAGCTCTCTGCTAAGTTGG LYM291 ER BamHI (SEQ ID NO: 4090) AAAGGATCCTCCTAGCAACAGAAGATCCAAG LYM293 XhoI,SacI LYM293 NF Xhol (SEQ ID NO: 4091) AAACTCGAGAGCTTCCTCCCTAGCTGTCC LYM293 EF Xhol (SEQ ID NO: 4092) AAACTCGAGGTGTAGCTTCCTCCCTAGCTG LYM293 NR SacI (SEQ ID NO: 4093) AAAGAGCTCCTATTCCAGGAGAAGAACAATAAGAG LYM293 ER Sad (SEQ ID NO: 4094) AAAGAGCTCCTATTCATGTTCCAGGAGAAGAAC LYM3 XhoI,KpnI LYM3 EF Xhol (SEQ ID NO: 4095) AATCTCGAGATTTATCTGCTTCAATGGCAAC LYM3 ER Kpnl (SEQ ID NO: 4096) ATAGGTACCCTAAGCATCATTCTGCCTACC LYM30 SalI,XhoI LYM30 NF Sail (SEQ ID NO: 4097) AAAGTCGACCCTCCATCCTTCAGTAATTGG LYM3O NR XhoI (SEQ ID NO: 4098) TTTCTCGAGTCAGTCTCCTTGGATGTTTGAGTTG LYM31 SalI,XhoI LYM31 NF Sail (SEQ ID NO: 4099) AAGGTCGACACTCCCAACGTCTACTCTTCC LYM31 EF Sail (SEQ ID NO: 4100) AATGTCGACCTCACCACTCCCAACGTCTAC LYM31 NR Xhol (SEQ ID NO: 4101) AAACTCGAGATGTAAGAATGAAATCTTGTAGCTC LYM31 ER Xhol (SEQ ID NO: 4102) AATCTCGAGTGCAAGGATGTAAGAATGAAATC LYM34 BamHI,KpnI LYM34 NF BamHI (SEQ ID NO: 4103) AAAGGATCCGAGATAATTAGCTCACTCCATGG LYM34 NR Kpnl (SEQ ID NO: 4104) TATGGTACCGAATTGGGCCTATGAGACG LYM35 SalI,XbaI LYM35 NF Sail (SEQ ID NO: 4105) AAAGTCGACAACACCTCTCTGGCTCTCTCC LYM35 NR Sad (SEQ ID NO: 4106) AAAGAGCTCTCCTAAGACTTTCTCAGCCATC LYM37 SalI,XbaI LYM37_NF Sail (SEQ ID NO: 4203) AAAGTCGACAAAGTTAGCGACCAAGAAACC LYM37_NR Xbal (SEQ ID NO: 4204) AAAT CT AGAC ATTTCTTTTGGATGGATGAAC LYM4 EcoRV,KpnI LYM4 NF EcoRV (SEQ ID NO: 4107) AAAGATATCACCTCGAAACCCTAGATCG LYM4 EF EcoRV (SEQ ID NO: 4108) AAAGATATCATTCCTCGACCAGCTCACG LYM4 NR Kpn (SEQ ID NO: 4109) TTAGGTACCACTCAAAGGAGAGCTTCAGCC 2016213786 11 Aug 2016

170 Gene Name Restriction Enzymes used for cloning Primers used for amplification LYM4 ER Kpnl (SEQ ID NO: 4110) TAAGGTACCGTTGGCATTCTTCAAACCAG LYM40 LYM40 NF Sail (SEQ ID NO: 4111) AAAGTCGACCTCGAGAGCTCAATGATTCG LYM40 NR Xbal (SEQ ID NO: 4112) AAATCTAGAACCAACCAATTAAAGGCTAATG LYM41 SalI,XbaI LYM41 NF Sail (SEQ ID NO: 4113) AAAGTCGACGATT GGTT GCTT GGGTTTG LYM41 NR Xbal (SEQ ID NO: 4114) AAATCTAGATGCTTTCTTTCAGAACATCTCC LYM42 SalI,XbaI LYM42 NF Sail (SEQ ID NO: 4115) AAAGTCGAC AACCT CT CCTCCT CGTC AC AC LYM42 EF Sail (SEQ ID NO: 4116) AAAGTCGACATCAAACCTCTCCTCCTCGTC LYM42 NR Xbal (SEQ ID NO: 4117) AATTCTAGATCACAGGAAGGAGGGGTAGTAACAG LYM42 ER Xbal (SEQ ID NO: 4118) AAATCTAGAATTTCCTGCTGTTCATTCAAAG LYM43 SalI,XbaI LYM43 NF Sail (SEQ ID NO: 4119) AAAGT CGACTC AGTGTTCTT CC ATT CTTT CC LYM43 NR Xbal (SEQ ID NO: 4120) AAATCTAGATTGAATTAGCAGCAGCAAGAG LYM44 SalI,XbaI LYM44 NF Sail (SEQ ID NO: 4121) AAAGTCGACCGAACTAACTAACCATCTCATCC LYM44 NR Xbal (SEQ ID NO: 4122) AAATCTAGAATCGTTCGATTATTATTGCTCC LYM5 EcoRV,PstI LYM5 EF EcoRV (SEQ ID NO: 4123) AAAGATATCTCCTCTTCTCAAACTCCATCTC LYM5 ER PstI (SEQ ID NO: 4124) AATCTGCAGGGTCCTGTCATGCTGTGTAGTC LYM51 SalI,XbaI LYM51 EF Sail (SEQ ID NO: 4125) AAAGTCGACAATTCACCTCCCAAGCAGAG LYM51 ER Xbal (SEQ ID NO: 4126) AAATCTAGAATACAAGGCCTGCACTACCTAC LYM52 EcoRV,XhoI LYM52 F Xhol (SEQ ID NO: 4127) AAACTCGAGAAACCCGATAAGAAAATGGC LYM52 ER EcoRV (SEQ ID NO: 4128) TTTGATATCCTAGTGCCATACGTGCCTAACCT LYM53 SalI,XbaI LYM53 NF Sail (SEQ ID NO: 4129) AAAGTCGACATCCTCTCTTTCCACTCCTAGC LYM53 NR Xbal (SEQ ID NO: 4130) AAATCTAGATAGCACTCAGCTTAATTGGATG LYM56 SalI,XbaI LYM56 F Sail (SEQ ID NO: 4131) AAAGTCGACCTCGCTTGCCCACTCCTT LYM56 F Sail (SEQ ID NO: 4131) AAAGTCGACCTCGCTTGCCCACTCCTT LYM56 NR Xbal (SEQ ID NO: 4132) AAATCTAGACTAGCATGATCCTGGATGTTTACTC LYM56 ER Xbal (SEQ ID NO: 4133) AAAT CT AGAAGC AGAGAT AGGC AT A AGTCC A LYM57 EcoRV,XhoI LYM57 NF EcoRV (SEQ ID NO: 4134) AAAGATATCACCACTAGGACTCAACGAGAAG 2016213786 11 Aug 2016

171 Gene Name Restriction Enzymes used for cloning Primers used for amplification LYM57 NR Xhol (SEQ ID NO: 4135) AACCT CGAGAGTAACAT CCGAACGTAT AC ACC LYM6 SmaI,KpnI LYM6 NF X/Smal (SEQ ID NO: 4136) ATACCCGGGAACCACGCGAAGACATGG LYM6 NR Kpnl (SEQ ID NO: 4137) TATGGTACCGGATCAGGTTATACTTCTTATTGAC LYM61 BamHI,XhoI LYM61 NF BamHI (SEQ ID NO: 4138) AAAGGAT CC AAGCCT GTT CT CTGT CGATT G LYM61 NR Xhol (SEQ ID NO: 4139) AAACTCGAGAATGCATGTCCTAGTCTTTACG LYM62 BamHI,KpnI LYM62 NF BamHI (SEQ ID NO: 4140) TTAGGATCCAACATTTACGCGATCCATTG LYM62 EF BamHI (SEQ ID NO: 4141) TTAGGATCCATCATCTGCTTTGTCTACCTCG LYM62 NR Kpnl (SEQ ID NO: 4142) ATCGGTACCTCAACTGAATTCGCTGAAACTTGTC LYM62 ER Kpnl (SEQ ID NO: 4143) AAAGGTACCGAAAACAAATGGAAGCAATCTG LYM66 EcoRV,XhoI LYM66 NF EcoRV (SEQ ID NO: 4144) AAAGATATCGAGACGCAAGAAACATAGCTC LYM66 NR Xhol (SEQ ID NO: 4145) AAACTCGAGCAATCACTGCTACAAATCCGT LYM67 SalI,XbaI LYM67 NF Sail (SEQ ID NO: 4146) T ATGT CGACT CTT CTTC ACT GAGGC AAGTTC LYM67 NR Xbal (SEQ ID NO: 4147) AAGTCTAGATCAAAGATCCATAACATTCCATGC LYM68 SalI,XhoI LYM68 NF Sail (SEQ ID NO: 4148) ATTGTCGACTTGAGATAAAGGCAAAATTACG LYM68 EF Sail (SEQ ID NO: 4149) TTTGTCGACGTCTCGTTTCAGATTCTTCTGC LYM68 NR Xhol (SEQ ID NO: 4150) TTCCTCGAGTCTCTAGAGTTGCATTCCTTCC LYM68 ER Xhol (SEQ ID NO: 4151) TGACTCGAGCATCGTTTACACTGAACCACTG LYM69 SalI,XbaI LYM69 NF Sail (SEQ ID NO: 4152) AAAGTCGACACCCAGGAACACATCATCATC LYM69 NR Xbal (SEQ ID NO: 4153) AAATCTAGAAGGACACGTCAAATGAGAAAAC LYM7 SalI,XbaI LYM7 NF Sail (SEQ ID NO: 4154) AAAGT CGACAGT CAGATCC ATT CCTCCTCC LYM7 NR Xbal (SEQ ID NO: 4155) AATT CT AGAAAAAGT AGC AGCCGGT CAT C LYM73 LYM73 EF Sail (SEQ ID NO: 4156) AACGT CGAC AATCTT GAC ACC ATCT CGCT C LYM73 ER StuI (SEQ ID NO: 4157) TTTAGGCCTCTCGCACATTATTTTGTACAGC LYM79 SalI,XbaI LYM79 F Sail (SEQ ID NO: 4158) AAAGTCGACGCGACAGAGAATCCATGGC LYM79 F Sail (SEQ ID NO: 4158) AAAGTCGACGCGACAGAGAATCCATGGC LYM79 NR Xbal (SEQ ID NO: 4159) AATTCTAGATCAAACTCCTCTTATATGCACCTGC 2016213786 11 Aug 2016

172 Gene Name Restriction Enzymes used for cloning Primers used for amplification LYM79 ER Xbal (SEQ ID NO: 4160) AAATCTAGATCAGAAACTAACTCCTCTTATATGCAC C LYM8 XhoI,KpnI LYM8 NF Xhol (SEQ ID NO: 4161) ATACTCGAGCTTCCCCGATAGAAATCCATC LYM8 NR Kpnl (SEQ ID NO: 4162) TAGGGTACCACCAAACAGCACATATGCGG LYM82 SalI,XbaI LYM82 EF Sail (SEQ ID NO: 4163) AAAGTCGACCGCAACCGGAGAGAAATC LYM82 ER Xbal (SEQ ID NO: 4164) AAATCTAGATCGACAATCTTCATACACAACG LYM83 LYM83 NF BamHI (SEQ ID NO: 4165) AAAGGATCCCGACAGTCACCACTCACCAAC LYM83 F2 BamHI (SEQ ID NO: 4166) AAAGGATCCTCCGCACGCAACTCAGTG LYM83 R2 Xhol (SEQ ID NO: 4167) AAACTCGAGCAACGGTAACACACAAGCATTC LYM83 R2 Xhol (SEQ ID NO: 4167) AAACTCGAGCAACGGTAACACACAAGCATTC LYM84 BamHI,XhoI LYM84 NF BamHI (SEQ ID NO: 4168) AAAGGATCCACCCAGAACCCGAAGAATG LYM84 F2 BamHI (SEQ ID NO: 4169) AATGGATCCTAAACCCAGAACCCGAAGAATG LYM84 R2 Xhol (SEQ ID NO: 4170) AAACTCGAGCAAACTGGAGCATAGCAACTAGG LYM84 R2 Xhol (SEQ ID NO: 4170) AAACTCGAGCAAACTGGAGCATAGCAACTAGG LYM86 BamHI,XhoI LYM86 EF BamHI (SEQ ID NO: 4171) AAAGGATCCCACACACCACAGTCGCAATC LYM86 ER Xhol (SEQ ID NO: 4172) AAACT CGAGAGAAT CGAT GC AGGTAACTACG LYM88 BamHI,XhoI LYM88 F BamHI (SEQ ID NO: 4173) AAAGGATCCACAATAAACAAGATAAATGGAGG LYM88 F BamHI (SEQ ID NO: 4173) AAAGGATCCACAATAAACAAGATAAATGGAGG LYM88 NR Xhol (SEQ ID NO: 4174) AAACTCGAGTCACACGCAACTTCAGGTTC LYM88 ER Xhol (SEQ ID NO: 4175) AAACTCGAGCAAACCGAATTATTACATCAGG LYM89 Sail,SacI LYM89 NF Sail (SEQ ID NO: 4176) AAAGTCGACGGCCGACACATCTGATCTAAC LYM89 NR Sad (SEQ ID NO: 4177) AAAGAGCTCTCCCAGAAATATATAAGAACAAGC LYM9 SalI,XbaI LYM9 NF Sail (SEQ ID NO: 4178) AAAGTCGACAACTCCCCAACCAAGCAG LYM9 NR Xbal (SEQ ID NO: 4179) AAATCTAGATTAGTACTAAGAGTCGGCTTTGGC LYM90 SalI,XbaI LYM90 NF Sail (SEQ ID NO: 4180) AAAGT CGACCT AAACCCT AACCCTAGATTGG LYM90 NR Xbal (SEQ ID NO: 4181) AAATCTAGAAGACTTGGCTAATGCTAACCTG LYM91 SalI,XbaI LYM91 F2 Sail (SEQ ID NO: 4182) TAAGTCGACCGTCTCTCAAGCTCGCAGC 173

Gene Name Restriction Enzymes used for cloning Primers used for amplification LYM91 F2 Sail (SEQ ID NO: 4182) TAAGTCGACCGTCTCTCAAGCTCGCAGC LYM91 R2 Xbal (SEQ ID NO: 4183) ATTTCTAGACGAGAGCCTCTAATGGATCACAG LYM91 R2 Xbal (SEQ ID NO: 4183) ATTTCTAGACGAGAGCCTCTAATGGATCACAG LYM93 LYM93 EF Sail (SEQ ID NO: 4184) AAAGTCGACATTGCACTGCATAGGGCTG LYM93 ER Xbal (SEQ ID NO: 4185) AAATCTAGACTAAGAGTTGAGCATGATAAATACGA C LYM95 SalI,XbaI LYM95 NF Sail (SEQ ID NO: 4186) AT AGT CG ACG AGAAAGT GGAAGAGAAC ATGG LYM95 EF Sail (SEQ ID NO: 4187) AAAGTCGACCCGCTGGAGAAAGTGGAAG LYM95 NR Xbal (SEQ ID NO: 4188) AAATCTAGAGTCCACAGATCCATGTCAAATC LYM95 ER Xbal (SEQ ID NO: 4189) AAATCTAGAGTGAATTTGATTTATTGCCAAC LYM99 BamHI,KpnI LYM99 NF BamHI (SEQ ID NO: 4190) AAAGGAT CCCCGACC ACGGATT GATT C LYM99 EF BamHI (SEQ ID NO: 4191) AAAGGATCCTTGACTTGGGTGTCTGGTCC LYM99 NR Kpnl (SEQ ID NO: 4192) AAAGGT ACCGT GCCTATGTCTTCCT AGC ATC LYM99 ER Kpnl (SEQ ID NO: 4193) AAAGGTACCATATTTAGGCGCCAGTAAAGAC

Table 26. Provided are the PCR primers used for cloning the genes of some embodiments of the invention. Fwd = forward primer; Rev = reverse primer; Nested = nested primer for PCR (internal primer); External = external primer for PCR. 2016213786 11 Aug 2016 5 To facilitate cloning of the cDNAs/ genomic sequences, a 8-12 bp extension was added to the 5' of each primer. The primer extension includes an endonuclease restriction site. The restriction sites were selected using two parameters: (a). The site did not exist in the cDNA sequence; and (b). The restriction sites in the forward and reverse primers were designed such that the digested cDNA is inserted in the sense 10 formation into the binary vector utilized for transformation.

Each digested PCR product was inserted into a high copy vector pBlue-script KS plasmid vector [pBlue-script KS plasmid vector, Hypertext Transfer Protocol://World Wide Web (dot) stratagene (dot) com/manuals/212205 (dot) pdf] or into plasmids originating from this vector. In cases where the pGXN/ pGXNa high copy 15 vector (originated from pBlue-script KS) was used, the PCR product was inserted upstream to the NOS terminator (SEQ ID NO: 4194) originated from pBI 101.3 binary vector (GenBank Accession No. U12640, nucleotides 4356 to 4693) and downstream to 2016213786 11 Aug 2016 174 the 35S promoter. The digested products and the linearized plasmid vector were ligated using T4 DNA ligase enzyme (Roche, Switzerland). In some cases PCR products were cloned without digestion into pCR-Blunt II-TOPO vector (Invitrogen).

Sequencing of the amplified PCR products was performed, using ABI 377 5 sequencer (Amersham Biosciences Inc). In all cases, after confirmation of the sequence of the cloned genes, the cloned cDNA accompanied or not with the NOS terminator was introduced into the modified pGI binary vector containing the 6669 promoter [pQFN or pQYN_6669] according to Table 27, via digestion with appropriate restriction endonucleases. In any case the insert was followed by single copy of the NOS 10 terminator (SEQ ID NO:4194).

High copy plasmids containing the cloned genes were digested with restriction endonucleases (New England BioLabs Inc) and cloned into binary vectors according to Table 27, below.

Binary vectors used for cloning: 15 Evolution of binary vectors construction: The plasmid pPI was constructed by inserting a synthetic poly-(A) signal sequence, originating from pGL3 basic plasmid vector (Promega, Acc No U47295; bp 4658-4811) into the Hindlll restriction site of the binary vector pBI101.3 (Clontech, Acc. No. U12640). pGI (pBXYN) is similar to pPI, but the original gene in the backbone, the GUS gene, was replaced by the GUS-Intron 20 gene followed by the NOS terminator (SEQ ID NO:4194) (Vancanneyt. G, el al MGG 220, 245-50, 1990). The modified pGI vector (pQXYN) is a modified version of the pGI vector in which the cassette is inverted between the left and right borders so the gene and its corresponding promoter are close to the right border and the NPTII gene is close to the left border. 25 Vectors used for cloning the polynucleotides of some embodiments of the invention: Cloned genes were digested from the high copy vectors and cloned into one of the following binary vectors: pQFN or pQYN_6669. pQFN (see Figure 2) and pQYN_6669 (see Figure 1) are modified pGI vectors in which the 35S promoter was replaced by the new At6669 promoter (SEQ ID 30 NO:4198). pQYN_6669 contains the GUSintron sequence, while pQFN lacks the GUSintron sequence 2016213786 11 Aug 2016 175

Table 27

Restriction enzyme sites used to clone identified genes according to some embodiments of the invention into binary vectors

Gene name Binary vector Restriction enzymes used for cloning into binary vector-FORWARD Restriction enzymes used for cloning into binary vector-REVERSE Restriction enzymes used for digesting the binary vector LYM1 pQFN Sail EcoRI Sail, EcoRI LYM10 pQFN Xhol Kpnl Xhol, Kpnl LYM100 pQYN 6669 Sail EcoRI Sail, EcoRI LYM102 pQFN BamHI Xhol BamHI, Xhol LYM103 pQFN BamHI Xhol BamHI, Xhol LYM105 pQFN BamHI Xhol BamHI, Xhol LYM106 pQYN 6669 Sail EcoRI Sail, EcoRI LYM107 pQFN BamHI Xhol BamHI, Xhol LYM109 pQFN Xhol StuI Xhol, StuI LYM110 pQFN BamHI Xhol BamHI, Xhol LYM111 pQFN Xhol EcoRI Xhol, EcoRI LYM112 pQFN BamHI Xhol BamHI, Xhol LYM113 pQYN 6669 Sail EcoRI Sail, EcoRI LYM115 pQFN BamHI Xhol BamHI, Xhol LYM116 pQYN 6669 Sail EcoRI Sail, EcoRI LYM117 pQFN BamHI EcoRV BamHI, StuI LYM118 pQFN BamHI Xhol BamHI, Xhol LYM119 pQYN 6669 Sail EcoRI Sail, EcoRI LYM12 pQFN Xhol Kpnl Xhol, Kpnl LYM120 pQFN BamHI Xhol BamHI, Xhol LYM121 pQFN BamHI Xhol BamHI, Xhol LYM122 G pQFN BamHI Xhol BamHI, Xhol LYM122 S pQFN BamHI Xhol BamHI, Xhol LYM123 pQFN BamHI Xhol BamHI, Xhol LYM125 pQFN BamHI Kpnl BamHI, Kpnl LYM126 pQFN BamHI Kpnl BamHI, Kpnl LYM127 pQFN BamHI Xhol BamHI, Xhol LYM128 pQFN BamHI Xhol BamHI, Xhol LYM129 pQFN Sail EcoRI Sail, EcoRI LYM13 pQFN Sail BamHI Sail, BamHI LYM130 pQYN 6669 Sail EcoRI Sail, EcoRI LYM131 pQFN Sail Xhol Sail, Xhol LYM132 pQFN BamHI Xhol BamHI, Xhol LYM134 pQFN BamHI Xhol BamHI, Xhol LYM135 pQFN Sail Kpnl Sail, Kpnl LYM136 pQFN BamHI Kpnl BamHI, Kpnl LYM137 pQYN 6669 Sail EcoRI Sail, EcoRI LYM138 pQFN Sail Ecll36II Sail, StuI LYM14 pQFN Sail BamHI Sail, BamHI LYM140 pQFN Xhol EcoRI Xhol, EcoRI LYM141 pQFN BamHI Kpnl BamHI, Kpnl LYM142 pQYN 6669 Sail EcoRI Sail, EcoRI LYM143 pQYN 6669 Sail EcoRI Sail, EcoRI LYM144 pQFN Sail EcoRV Sail, StuI LYM145 pQFN BamHI Xhol BamHI, Xhol 2016213786 11 Aug 2016

176 Gene name Binary vector Restriction enzymes used for cloning into binary vector-FORWARD Restriction enzymes used for cloning into binary vector-REVERSE Restriction enzymes used for digesting the binary vector LYM146 pOFN Kpnl Kpnl Kpnl, Kpnl LYM147 pOFN Sail EcoRI Sail, EcoRI LYM148 pOFN BamHI Xbal BamHI, Xhol LYM149 pQYN 6669 Sail EcoRI Sail, EcoRI LYM15 pOFN Sail EcoRI Sail, EcoRI LYM152 pQYN 6669 Sail EcoRI Sail, EcoRI LYM153 pQYN 6669 Sail EcoRI Sail, EcoRI LYM154 pOFN Xhol StuI Xhol, StuI LYM155 pQYN 6669 Sail EcoRI Sail, EcoRI LYM156 pOFN StuI StuI Smal, Smal LYM157 G pQYN_6669 Sail EcoRI Sail, EcoRI LYM157 S pOFN Sail StuI Sail, StuI LYM159 pQYN 6669 Sail EcoRI Sail, EcoRI LYM16 pOFN Sail EcoRI Sail, EcoRI LYM160 pQYN 6669 Sail EcoRI Sail, EcoRI LYM161 pOFN BamHI Xhol BamHI, Xhol LYM162 pOFN BamHI Xhol BamHI, Xhol LYM164 pQYN 6669 Sail EcoRI Sail, EcoRI LYM165 pOFN Xhol Eel 13611 Xhol, StuI LYM17 pOFN Smal Kpnl Smal, Kpnl LYM170 pQYN 6669 Sail EcoRI Sail, EcoRI LYM172 pOFN BamHI Xhol BamHI, Xhol LYM173 pOFN BamHI Xhol BamHI, Xhol LYM174 pOFN BamHI Kpnl BamHI, Kpnl LYM175 pQYN 6669 Sail EcoRI Sail, EcoRI LYM176 pQYN 6669 Sail EcoRI Sail, EcoRI LYM178 pQYN 6669 Sail EcoRI Sail, EcoRI LYM179 pOFN Sail StuI Sail, StuI LYM180 pOFN BamHI Xhol BamHI, Xhol LYM181 pOFN BamHI EcoRV BamHI, StuI LYM183 pOFN Sail Xbal Sail, StuI LYM184 pOFN BamHI Xhol BamHI, Xhol LYM185 pOFN BamHI Kpnl BamHI, Kpnl LYM186 pOFN Sail Eel 13611 Sail, StuI LYM188 pOFN BamHI Xhol BamHI, Xhol LYM189 pQYN 6669 Sail EcoRI Sail, EcoRI LYM19 pQYN 6669 Sail EcoRI Sail, EcoRI LYM192 pOFN Xhol EcoRV Xhol, StuI LYM193 pOFN BamHI Xhol BamHI, Xhol LYM194 pOFN Sail Xhol Sail, Sail LYM196 pOFN BamHI Xhol BamHI, Xhol LYM197 pOFN BamHI Xhol BamHI, Xhol LYM198 pOFN BamHI Xhol BamHI, Xhol LYM2 pOFN EcoRV Kpnl Smal, Kpnl LYM20 pOFN EcoRV Kpnl Smal, Kpnl LYM200 pOFN BamHI Xhol BamHI, Xhol LYM201 pOFN BamHI Xhol BamHI, Xhol LYM203 pOFN BamHI Xhol BamHI, Xhol LYM204 pOFN BamHI Xhol BamHI, Xhol LYM206 pOFN Xhol EcoRV Xhol, StuI 2016213786 11 Aug 2016 177 Gene name Binary vector Restriction enzymes used for cloning into binary vector-FORWARD Restriction enzymes used for cloning into binary vector-REVERSE Restriction enzymes used for digesting the binary vector LYM207 pOFN BamHI Kpnl BamHI, Kpnl LYM208 pOFN BamHI Kpnl BamHI, Kpnl LYM21 pOFN EcoRV Kpnl Smal, Kpnl LYM212 pQYN 6669 Sail EcoRI Sail, EcoRI LYM213 pOFN BamHI Xhol BamHI, Xhol LYM215 pOFN BamHI Xhol BamHI, Xhol LYM217 pQYN 6669 Sail EcoRI Sail, EcoRI LYM219 pOFN BamHI Kpnl BamHI, Kpnl LYM22 pQYN 6669 Sail EcoRI Sail, EcoRI LYM220 pOFN BamHI EcoRV BamHI, StuI LYM221 pOFN BamHI Xhol BamHI, Xhol LYM223 pOFN Xhol EcoRI Xhol, EcoRI LYM224 pOFN BamHI Xhol BamHI, Xhol LYM227 pOFN BamHI Kpnl BamHI, Kpnl LYM228 pOFN StuI Kpnl Kpnl, EcoRV LYM23 pOFN BamHI Kpnl BamHI, Kpnl LYM232 pOFN BamHI Xhol BamHI, Xhol LYM233 pOFN BamHI Xhol BamHI, Xhol LYM234 pOFN BamHI Xhol BamHI, Xhol LYM236 pOFN Sail EcoRI Sail, EcoRI LYM238 pOFN Smal Kpnl Smal, Kpnl LYM239 pOFN BamHI Xhol BamHI, Xhol LYM24 pOFN Sail EcoRI Sail, EcoRI LYM240 pOFN BamHI Kpnl BamHI, Kpnl LYM241 pOFN BamHI Xhol BamHI, Xhol LYM242 pOFN BamHI Xhol BamHI, Xhol LYM243 pOFN BamHI Xhol BamHI, Xhol LYM245 pOFN BamHI Kpnl BamHI, Kpnl LYM248 pOFN BamHI EcoRV BamHI, StuI LYM249 pOFN BamHI Kpnl BamHI, Kpnl LYM250 pOFN Sail Xbal Sail, StuI LYM251 pOFN Sail Eel 13611 Sail, StuI LYM252 pOFN BamHI Kpnl BamHI, Kpnl LYM254 pOFN Sail BamHI Sail, BamHI LYM255 pOFN BamHI Xhol BamHI, Xhol LYM256 pOFN BamHI Xhol BamHI, Xhol LYM26 pQYN 6669 Sail EcoRI Sail, EcoRI LYM260 pOFN BamHI Kpnl BamHI, Kpnl LYM261 pOFN Smal Kpnl Smal, Kpnl LYM267 pOFN Sail EcoRV Sail, StuI LYM268 pOFN Xhol EcoRV Xhol, StuI LYM270 pOFN BamHI Xhol BamHI, Xhol LYM271 pOFN BamHI Xhol BamHI, Xhol LYM273 G pQFN BamHI Xhol BamHI, Xhol LYM273 S pOFN BamHI Xhol BamHI, Xhol LYM274 pOFN BamHI Xhol BamHI, Xhol LYM277 pOFN Sail Eel 13611 Sail, StuI LYM278 pQYN 6669 Sail EcoRI Sail, EcoRI LYM283 pOFN Smal Kpnl Smal, Kpnl LYM284 pOFN BamHI Kpnl BamHI, Kpnl 2016213786 11 Aug 2016

178 Gene name Binary vector Restriction enzymes used for cloning into binary vector-FORWARD Restriction enzymes used for cloning into binary vector-REVERSE Restriction enzymes used for digesting the binary vector LYM285 pOFN Xhol EcoRV Xhol, StuI LYM287 pOFN Xhol EcoRV Xhol, StuI LYM288 pOFN Xhol EcoRI Xhol, EcoRI LYM289 pQYN 6669 Sail EcoRI Sail, EcoRI LYM290 pOFN BamHI Kpnl BamHI, Kpnl LYM291 pOFN Sail BamHI Sail, BamHI LYM293 pOFN Xhol EcoRI Xhol, EcoRI LYM3 pOFN Xhol Kpnl Xhol, Kpnl LYM30 pOFN Sail Xhol Sail, Xhol LYM31 pOFN Sail Xhol Sail, Xhol LYM32 pOFN BamHI Kpnl BamHI, Kpnl LYM34 pOFN BamHI Kpnl BamHI, Kpnl LYM35 pQYN 6669 Sail EcoRI Sail, EcoRI LYM36 pOFN StuI StuI StuI, StuI LYM37 pQYN 6669 Sail EcoRI Sail, EcoRI LYM38 pOFN Sail BamHI Sail, BamHI LYM4 pOFN EcoRV Kpnl Smal, Kpnl LYM40 pOFN Sail EcoRV Sail, StuI LYM41 pQYN 6669 Sail EcoRI Sail, EcoRI LYM42 pQYN 6669 Sail EcoRI Sail, EcoRI LYM43 pQYN 6669 Sail EcoRI Sail, EcoRI LYM44 pQYN 6669 Sail EcoRI Sail, EcoRI LYM5 pOFN Sail BamHI Sail, BamHI LYM51 pQYN 6669 Sail EcoRI Sail, EcoRI LYM52 pOFN Xhol EcoRV Xhol, StuI LYM53 pQYN 6669 Sail EcoRI Sail, EcoRI LYM56 pQYN 6669 Sail EcoRI Sail, EcoRI LYM57 pOFN EcoRV Xhol Smal, Xhol LYM6 pOFN Smal Kpnl Smal, Kpnl LYM61 pOFN BamHI Xhol BamHI, Xhol LYM62 pOFN BamHI Kpnl BamHI, Kpnl LYM66 pOFN EcoRV Xhol Smal, Xhol LYM67 pQYN 6669 Sail EcoRI Sail, EcoRI LYM68 pOFN Sail Xhol Sail, Xhol LYM69 pQYN 6669 Sail EcoRI Sail, EcoRI LYM7 pOFN Sail EcoRI Sail, EcoRI LYM73 pOFN Sail StuI Sail, StuI LYM74 pOFN Sail Eel 13611 Sail, StuI LYM79 pQYN 6669 Sail EcoRI Sail, EcoRI LYM8 pOFN Xhol Kpnl Xhol, Kpnl LYM82 pQYN 6669 Sail EcoRI Sail, EcoRI LYM83 pOFN BamHI Xhol BamHI, Xhol LYM84 pOFN BamHI Xhol BamHI, Xhol LYM86 pOFN BamHI Xhol BamHI, Xhol LYM88 pOFN BamHI Xhol BamHI, Xhol LYM89 pQYN 6669 Sail EcoRI Sail, EcoRI LYM9 pOFN Sail EcoRI Sail, EcoRI LYM90 pQYN 6669 Sail EcoRI Sail, EcoRI LYM91 pQYN 6669 Sail EcoRI Sail, EcoRI LYM93 pOFN Sail Xhol Sail, Xhol LYM95 pQYN 6669 Sail EcoRI Sail, EcoRI 2016213786 11 Aug 2016 179 Gene name Binary vector Restriction enzymes used for cloning into binary vector-FORWARD Restriction enzymes used for cloning into binary vector-REVERSE Restriction enzymes used for digesting the binary vector LYM99 POFN BamHI Kpnl BamHI, Kpnl Table 27.

Table 28 5 Genes cloned from cDNA libraries or genomic DNA in a High copy number plasmid Gene Name High copy plasmid Amplified from Organism Origin Polynucleotide SEQ ID NO: Polypeptide SEO ID NO: LYM1 pGXN (pKG+Nos+35S) RICE Oryza sativa L. Japonica ND cDNA 3481 240 LYM10 pKS(Pks_J) RICE Oryza sativa L. Japonica ND cDNA 3490 249 LYM100 pGXN (pKG+Nos+35S) BARLEY Hordeum vulgare L. Manit cDNA 3542 301 LYM102 pKS(Pks_J) RICE Oryza sativa L. Japonica ND cDNA 3543 302 LYM103 pKS(PksJ) MAIZE Zea mays L. Pioneer 30G54 cDNA 3544 3689 LYM105 pKS(PksJ) BARLEY Hordeum villa a re L. Manit cDNA 3545 3690 LYM106 pGXN (pKG+Nos+35S) BARLEY Hordeum vulgare L. Manit cDNA 3546 305 LYM107 pKS(PksJ) MAIZE Zea mays L. ND cDNA 3589 349 LYM109 pGXNa MAIZE Zea mays L. ND cDNA 3590 3702 LYM110 pKS(PksJ) MAIZE Zea mays L. ND cDNA 3547 3691 LYM111 pGXNa MAIZE Zea mays L. Pioneer 30G54 cDNA 3548 307 LYM112 pKS(PksJ) MAIZE Zea mays L. Pioneer 30G54 cDNA 3591 3703 LYM113 pGXN (pKG+Nos+3 5 S) MAIZE Zea mays L. Pioneer 30G54 cDNA 3592 352 LYM115 pKS(PksJ) MAIZE Zea mays L. ND cDNA 3593 3704 LYM116 pGXN (pKG+Nos+35S) MAIZE Zea mays L. ND cDNA 3594 354 LYM117 Topo B MAIZE Zea mays L. ND cDNA 3595 3705 2016213786 11 Aug 2016 180 Gene Name High copy plasmid Amplified from Organism Origin Polynucleotide SEQ ID NO: Polypeptide SEQIDNO: LYM118 GeneArt 3596 356 LYM119 pGXN (pKG+Nos+35S) MAIZE Zea mays L. ND cDNA 3549 3692 LYM12 pKS(PksJ) RICE Oryza sativa L. Japonica ND cDNA 3491 250 LYM120 pKS(PksJ) RICE Oryza sativa L. Japonica ND cDNA 3550 309 LYM121 pKS(PksJ) RICE Oryza sativa L. Japonica ND cDNA 3597 357 LYM122G Topo B RICE Oryza sativa L. Japonica ND Genomic 3739 310 LYM122 S GeneArt 3551 310 LYM123 GeneArt 3598 358 LYM125 Topo B RICE Oryza sativa L. Japonica ND cDNA 3552 311 LYM126 GeneArt 3553 312 LYM127 Topo B RICE Oryza sativa L. Japonica ND cDNA 3554 313 LYM128 pKS(PksJ) RICE Oryza sativa L. Japonica ND cDNA 3555 314 LYM129 pGXN (pKG+Nos+35S) RICE Oryza sativa L. Indica ND+ RICE Oryza sativa L. Japonica ND cDNA 3556 315 LYM13 pKS(PksJ) RICE Oryza sativa L. Japonica ND cDNA 3492 251 LYM130 pGXN (pKG+Nos+35S) RICE Oryza sativa L. Indica ND cDNA 3557 316 LYM131 pGXNa RICE Oryza sativa L. Japonica ND cDNA 3558 3693 LYM132 pKS(PksJ) RICE Oryza sativa L. Japonica ND cDNA 3559 318 LYM134 pKS(PksJ) RICE Oryza sativa L. Japonica ND cDNA 3560 319 LYM135 Topo B RICE Oryza sativa L. Japonica ND cDNA 3599 359 LYM136 pKS(PksJ) RICE Oryza sativa L. Japonica ND cDNA 3561 3694 2016213786 11 Aug 2016 181 Gene Name High copy plasmid Amplified from Organism Origin Polynucleotide SEQ ID NO: Polypeptide SEQIDNO: LYM137 pGXN (pKG+Nos+35S) BARLEY Hordeum vulgare L. Manit cDNA 3562 321 LYM138 pGXN (pKG+Nos+35S) RICE Oryza sativa L. Japonica ND cDNA 3600 360 LYM14 pKS(PksJ) RICE Oryza sativa L. Japonica ND cDNA 3493 252 LYM140 pGXNa BARLEY Hordeum vulgare L. Manit cDNA 3563 322 LYM141 Topo B RICE Oryza sativa L. Japonica ND cDNA 3564 323 LYM142 pGXN (pKG+Nos+35S) BARLEY Hordeum vulgare L. Manit cDNA 3565 324 LYM143 pGXN (pKG+Nos+35S) RICE Oryza sativa L. Japonica ND cDNA 3566 325 LYM144 pKS(PksJ) RICE Oryza sativa L. Japonica ND cDNA 3567 3695 LYM145 pKS(PksJ) RICE Oryza sativa L. ND cDNA 3568 327 LYM146 Topo B MAIZE Zea mays L. ND Genomic 3601 3706 LYM147 pGXN (pKG+Nos+35S) MAIZE Zea mays L. ND cDNA 3602 3707 LYM148 pKS(PksJ) BARLEY Hordeum vulgare L. Manit cDNA 3569 3696 LYM149 pGXN (pKG+Nos+35S) BARLEY Hordeum vulgare L. Manit cDNA 3570 329 LYM15 pGXN (pKG+Nos+35S) RICE Oryza sativa L. Japonica ND cDNA 3494 253 LYM152 pGXN (pKG+Nos+35S) ARABIDOPSIS Arabidopsis thaliana Transgenic Columbia cDNA 3571 330 LYM153 pGXN (pKG+Nos+35S) RICE Oryza sativa L. Japonica ND cDNA 3572 331 LYM154 GeneArt 3603 363 LYM155 pGXN (pKG+Nos+35S) BARLEY Hordeum vulgare L. Manit cDNA 3604 3708 LYM156 pGXNa BARLEY Hordeum vulgare L. Manit cDNA 3573 332 2016213786 11 Aug 2016 182 Gene Name High copy plasmid Amplified from Organism Origin Polynucleotide SEQ ID NO: Polypeptide SEQIDNO: LYM157_G pGXN (pKG+Nos+35S) BARLEY Hordeum vulgare L. Manit cDNA 3574 333 LYM157 S GeneArt 3574 333 LYM159 pGXN (pKG+Nos+35S) BARLEY Hordeum vulgare L. Manit cDNA 3575 3697 LYM16 pGXN (pKG+Nos+35S) RICE Oryza sativa L. ND cDNA 3495 254 LYM160 pGXN (pKG+Nos+35S) BARLEY Hordeum vulgare L. Manit cDNA 3576 3698 LYM161 pKS(PksJ) BARLEY Hordeum vulgare L. Manit cDNA 3577 3699 LYM162 pKS(PksJ) MAIZE Zea mays L. ND cDNA 3578 337 LYM164 pGXN (pKG+Nos+35S) RICE Oryza sativa L. ND cDNA 3579 3700 LYM165 Topo B MAIZE Zea mays L. Pioneer 30G54 cDNA 3580 339 LYM17 pKS(PksJ) RICE Oryza sativa L. ND cDNA 3496 255 LYM170 pGXN (pKG+Nos+35S) RICE Oryza sativa L. ND cDNA 3581 341 LYM172 pKS(PksJ) RICE Oryza sativa L. Indica ND cDNA 3582 342 LYM173 pKS(PksJ) RICE Oryza sativa L. Japonica ND cDNA 3583 343 LYM174 pKS(PksJ) SORGHUM Sorghum bicolor Monsanto S5 cDNA 3584 344 LYM175 pGXN (pKG+Nos+35S) RICE Oryza sativa L. ND cDNA 3585 345 LYM176 pGXN (pKG+Nos+35S) RICE Oryza sativa L. Japonica ND cDNA 3586 346 LYM178 pGXN (pKG+Nos+35S) ARABIDOPSIS Arabidopsis thaliana ND cDNA 3587 347 LYM179 pGXNa MAIZE Zea mays L. Pioneer 30G54 cDNA 3588 3701 LYM180 pKS(PksJ) BARLEY Hordeum vulgare L. Manit cDNA 3605 365 LYM181 Topo B BARLEY Hordeum vulgare L. Manit cDNA 3606 366 LYM183 Topo B BARLEY Hordeum vulgare L. Manit cDNA 3655 3733 2016213786 11 Aug 2016 183 Gene Name High copy plasmid Amplified from Organism Origin Polynucleotide SEQ ID NO: Polypeptide SEQIDNO: LYM184 Topo B BARLEY Hordeum vulgare L. Manit cDNA 3607 3709 LYM185 pKS(PksJ) BARLEY Hordeum vulgare L. Manit cDNA 3608 369 LYM186 pGXN (pKG+Nos+35S) BARLEY Hordeum vulgare L. Manit cDNA 3609 3710 LYM188 pKS(PksJ) BARLEY Hordeum vulgare L. Manit cDNA 3610 371 LYM189 pGXN (pKG+Nos+35S) BARLEY Hordeum vulgare L. Manit cDNA 3611 3711 LYM19 pGXN (pKG+Nos+35S) RICE Oryza sativa L. Japonica ND cDNA 3497 256 LYM192 pKS(PksJ) BARLEY Hordeum vulgare L. Manit cDNA 3612 3712 LYM193 pKS(PksJ) BARLEY Hordeum vulgare L. Manit cDNA 3613 374 LYM194 GeneArt 3614 3713 LYM196 Topo B MAIZE Zea mays L. ND cDNA 3615 376 LYM197 pKS(PksJ) MAIZE Zea mays L. ND cDNA 3616 3714 LYM198 pKS(PksJ) MAIZE Zea mays L. ND cDNA 3617 378 LYM2 pKS(PksJ) RICE Oryza sativa L. ND cDNA 3482 241 LYM20 pKS(PksJ) RICE Oryza sativa L. Japonica ND cDNA 3498 257 LYM200 pKS(PksJ) MAIZE Zea mays L. ND cDNA 3657 419 LYM201 pKS(PksJ) MAIZE Zea mays L. ND cDNA 3618 379 LYM203 pKS(PksJ) MAIZE Zea mays L. ND cDNA 3619 380 LYM204 Topo B MAIZE Zea mays L. Pioneer 30G54 cDNA 3620 381 LYM206 pKS(PksJ) MAIZE Zea mays L. ND cDNA 3621 3715 LYM207 Topo B MAIZE Zea mays L. Pioneer 30G54 cDNA 3622 3716 LYM208 pKS(PksJ) MAIZE Zea mays L. Pioneer 30G54 cDNA 3623 384 2016213786 11 Aug 2016 184 Gene Name High copy plasmid Amplified from Organism Origin Polynucleotide SEQ ID NO: Polypeptide SEQIDNO: LYM21 pKS(PksJ) RICE Oryza sativa L. Japonica ND cDNA 3499 258 LYM212 pGXN (pKG+Nos+35S) MAIZE Zea mays L. ND cDNA 3624 3717 LYM213 pKS(PksJ) MAIZE Zea mays L. ND cDNA 3625 386 LYM215 pKS(PksJ) MAIZE Zea mays L. ND cDNA 3626 3718 LYM217 pGXN MAIZE Zea mays L. ND cDNA 3627 3719 LYM219 pKS(PksJ) MAIZE Zea mays L. Pioneer 30G54 cDNA 3628 3720 LYM22 pGXN (pKG+Nos+35S) RICE Oryza sativa L. Japonica ND cDNA 3500 259 LYM220 pKS(PksJ) MAIZE Zea mays L. Pioneer 30G54 cDNA 3629 3721 LYM221 pKS(PksJ) MAIZE Zea mays L. Pioneer 30G54 cDNA 3630 3722 LYM223 pGXNa MAIZE Zea mays L. Pioneer 30G54 cDNA 3631 392 LYM224 pKS(PksJ) MAIZE Zea mays L. Pioneer 30G54 cDNA 3632 3723 LYM227 GeneArt 3633 394 LYM228 Topo B MAIZE Zea mays L. Pioneer 30G54 cDNA 3634 3724 LYM23 pKS(PksJ) RICE Oryza sativa L. Japonica ND cDNA 3501 260 LYM232 Topo B RICE Oryza sativa L. Japonica ND cDNA 3635 3725 LYM233 GeneArt 3636 397 LYM234 GeneArt 3637 398 LYM236 pGXN (pKG+Nos+35S) RICE Oryza sativa L. Japonica ND cDNA 3638 3726 LYM238 Topo B RICE Oryza sativa L. Japonica ND cDNA 3639 400 LYM239 pKS(PksJ) RICE Oryza sativa L. Japonica ND cDNA 3640 3727 LYM24 pGXN (pKG+Nos+35S) RICE Oryza sativa L. Japonica ND cDNA 3502 261 2016213786 11 Aug 2016 185 Gene Name High copy plasmid Amplified from Organism Origin Polynucleotide SEQ ID NO: Polypeptide SEQIDNO: LYM240 pKS(PksJ) RICE Oryza sativa L. Japonica ND cDNA 3641 402 LYM241 Topo B RICE Oryza sativa L. Japonica ND cDNA 3642 3728 LYM242 pKS(PksJ) RICE Oryza sativa L. Indica ND cDNA 3643 404 LYM243 pKS(PksJ) RICE Oryza sativa L. Japonica ND cDNA 3644 405 LYM245 pKS(PksJ) RICE Oryza sativa L. Japonica ND cDNA 3645 406 LYM248 pKS(PksJ) RICE Oryza sativa L. Indica ND cDNA 3646 3729 LYM249 Topo B RICE Oryza sativa L. Japonica ND+ RICE Oryza sativa L. ND cDNA 3647 3730 LYM250 pGXN (pKG+Nos+35S) RICE Oryza sativa L. Japonica ND cDNA 3648 409 LYM251 Topo B RICE Oryza sativa L. Japonica ND cDNA 3649 410 LYM252 pKS(PksJ) RICE Oryza sativa L. Indica ND+ RICE Oryza sativa L. Japonica ND cDNA 3650 411 LYM254 Topo B RICE Oryza sativa L. Japonica ND cDNA 3651 3731 LYM255 pKS(PksJ) RICE Oryza sativa L. Japonica ND cDNA 3652 3732 LYM256 pKS(PksJ) RICE Oryza sativa L. Japonica ND cDNA 3656 418 LYM26 pGXN (pKG+Nos+35S) BARLEY Hordeum vulgare L. Manit cDNA 3503 262 LYM260 Topo B RICE Oryza sativa L. Japonica ND cDNA 3653 414 LYM261 Topo B RICE Oryza sativa L. Japonica ND cDNA 3654 415 LYM267 pKS(PksJ) MAIZE Zea mays L. ND cDNA 3658 420 2016213786 11 Aug 2016 186 Gene Name High copy plasmid Amplified from Organism Origin Polynucleotide SEQ ID NO: Polypeptide SEQIDNO: LYM268 Topo B RICE Oryza sativa L. Indica ND+ RICE Oryza sativa L. Japonica ND cDNA 3659 421 LYM270 pKS(PksJ) MAIZE Zea mays L. ND cDNA 3660 422 LYM271 pKS(PksJ) MAIZE Zea mays L. Pioneer 30G54 cDNA 3661 423 LYM273_G pKS(PksJ) RICE Oryza sativa L. Japonica ND Genomic 3738 425 LYM273 S GeneArt 3662 425 LYM274 pKS(PksJ) RICE Oryza sativa L. Japonica ND cDNA 3663 3734 LYM277 Topo B RICE Oryza sativa L. Japonica ND cDNA 3664 3735 LYM278 pGXN (pKG+Nos+35S) BARLEY Hordeum vulgare L. Manit cDNA 3665 3736 LYM283 Topo B RICE Oryza sativa L. ND cDNA 3666 429 LYM284 pKS(PksJ) RICE Oryza sativa L. Japonica ND cDNA 3667 430 LYM285 pKS(PksJ) RICE Oryza sativa L. Japonica ND cDNA 3668 431 LYM287 pKS(PksJ) RICE Oryza sativa L. Japonica ND cDNA 3669 432 LYM288 pGXNa RICE Oryza sativa L. Indica ND+ RICE Oryza sativa L. Japonica ND cDNA 3670 3737 LYM289 pGXN (pKG+Nos+35S) BARLEY Hordeum vulgare L. Manit cDNA 3671 434 LYM290 pKS(PksJ) MAIZE Zea mays L. ND cDNA 3672 435 LYM291 pKS(PksJ) RICE Oryza sativa L. Japonica ND cDNA 3673 436 LYM293 pGXNa RICE Oryza sativa L. Indica ND cDNA 3674 437 LYM3 pKS(PksJ) RICE Oryza sativa L. Indica ND cDNA 3483 3675 LYM30 pGXNa RICE Oryza sativa L. ND cDNA 3504 3677 2016213786 11 Aug 2016 187 Gene Name High copy plasmid Amplified from Organism Origin Polynucleotide SEQ ID NO: Polypeptide SEQIDNO: LYM31 pGXNa RICE Oryza sativa L. ND cDNA 3505 264 LYM32 GeneArt 3506 265 LYM34 pKS(PksJ) RICE Oryza sativa L. Indica ND cDNA 3507 3678 LYM35 pGXN (pKG+Nos+35S) RICE Oryza sativa L. ND cDNA 3508 267 LYM36 GeneArt 3509 268 LYM37 pGXN (pKG+Nos+35S) RICE Oryza sativa L. Japonica ND cDNA 3510 269 LYM38 GeneArt 3511 270 LYM4 pKS(PksJ) RICE Oryza sativa L. ND cDNA 3484 243 LYM40 Topo B RICE Oryza sativa L. Japonica ND cDNA 3512 271 LYM41 pGXN (pKG+Nos+35S) RICE Oryza sativa L. Japonica ND cDNA 3513 272 LYM42 pGXN (pKG+Nos+35S) RICE Oryza sativa L. Japonica ND cDNA 3514 273 LYM43 pGXN (pKG+Nos+35S) RICE Oryza sativa L. ND cDNA 3515 274 LYM44 pGXN (pKG+Nos+35S) RICE Oryza sativa L. Japonica ND cDNA 3516 275 LYM5 pKS(PksJ) RICE Oryza sativa L. Indica ND cDNA 3485 244 LYM51 pGXN (pKG+Nos+35S) BARLEY Hordeum vulgare L. Manit cDNA 3517 3679 LYM52 pKS(PksJ) BARLEY Hordeum vulgare L. Manit cDNA 3518 277 LYM53 pGXN (pKG+Nos+35S) MAIZE Zea mays L. ND cDNA 3519 3680 LYM56 pGXN (pKG+Nos+35S) BARLEY Hordeum vulgare L. Manit cDNA 3520 3681 LYM57 pKS(PksJ) RICE Oryza sativa L. Japonica ND cDNA 3521 3682 LYM6 pKS(PksJ) RICE Oryza sativa L. ND cDNA 3486 3676 LYM61 pKS(PksJ) MAIZE Zea mays L. ND cDNA 3522 3683 LYM62 pKS(PksJ) MAIZE Zea mays L. ND cDNA 3523 3684 LYM66 pKS(PksJ) BARLEY Hordeum vulgare L. Manit cDNA 3524 3685 2016213786 11 Aug 2016 188 Gene Name High copy plasmid Amplified from Organism Origin Polynucleotide SEQ ID NO: Polypeptide SEQIDNO: LYM67 pGXN (pKG+Nos+35S) RICE Oryza sativa L. ND cDNA 3525 284 LYM68 pGXNa RICE Oryza sativa L. ND cDNA 3526 3686 LYM69 pGXN (pKG+Nos+35S) RICE Oryza sativa L. ND cDNA 3527 286 LYM7 pGXN (pKG+Nos+35S) RICE Oryza sativa L. ND cDNA 3487 246 LYM73 Topo B RICE Oryza sativa L. ND cDNA 3528 287 LYM74 GeneArt 3529 288 LYM79 pGXN (pKG+Nos+35S) MAIZE Zea mays L. ND cDNA 3530 3687 LYM8 pKS(PksJ) RICE Oryza sativa L. Japonica ND cDNA 3488 247 LYM82 pGXN (pKG+Nos+35S) BARLEY Hordeum vulgare L. Manit cDNA 3531 290 LYM83 Topo B BARLEY Hordeum vulgare L. Manit cDNA 3532 3688 LYM84 pKS(PksJ) BARLEY Hordeum vulgare L. Manit cDNA 3533 292 LYM86 pKS(PksJ) RICE Oryza sativa L. Indica ND cDNA 3534 293 LYM88 pKS(PksJ) ARABIDOPSIS Arabidopsis thaliana Transgenic Columbia cDNA 3535 294 LYM89 pGXN (pKG+Nos+35S) ARABIDOPSIS Arabidopsis thaliana Transgenic Columbia cDNA 3536 295 LYM9 pGXN (pKG+Nos+35S) RICE Oryza sativa L. ND cDNA 3489 248 LYM90 pGXN (pKG+Nos+35S) BARLEY Hordeum vulgare L. Manit cDNA 3537 296 LYM91 pGXN (pKG+Nos+35S) BARLEY Hordeum vulgare L. Manit cDNA 3538 297 LYM93 Topo B BARLEY Hordeum vulgare L. Manit cDNA 3539 298 LYM95 pGXN (pKG+Nos+35S) BARLEY Hordeum vulgare L. Manit cDNA 3541 300 LYM99 pKS(PksJ) BARLEY Hordeum vulgare L. Manit cDNA 3540 299 2016213786 11 Aug 2016 189

Table 28: Cloned and synthetic genes are provided along with the sequence identifiers of their polynucleotides and polypeptides. Also provided are the source organism, tissue and the cloning vectors. ND = not a determined ecotype. 5 Selected DNA sequences were synthesized by a commercial supplier GeneArt,

GmbH [Hypertext Transfer Protocol://World Wide Web (dot) geneart (dot) com/)]. Synthetic DNA is designed in silico. Suitable restriction enzymes sites were added to the cloned sequences at the 5' end and at the 3’ end to enabled later cloning into the pQFN/ pQYN_6669 binary vectors downstream of the 6669 promoter (SEQ ID 10 NO:4198). EXAMPLE 8

TRANSFORMING AGROBACTERIUM TUMEFACIENS CELLS WITH BINARY 15 VECTORS HARBORING PUTATIVE GENES

Each of the binary vectors described in Example 7 above are used to transform Agrobacterium cells. Two additional binary constructs, having a GUS/Luciferase reporter gene replacing the selected gene (positioned downstream of the At6669 promoter), are used as negative controls. 20 The binary vectors are introduced to Agrobacterium tumefaciens GV301, or LB4404 competent cells (about 109 cells/mL) by electroporation. The electroporation is performed using a MicroPulser electroporator (Biorad), 0.2 cm cuvettes (Biorad) and EC-2 electroporation program (Biorad). The treated cells are cultured in LB liquid medium at 28 °C for 3 hours, then plated over LB agar supplemented with gentamycin 25 (50 mg/L; for Agrobacterium strains GV301) or streptomycin (300 mg/L; for

Agrobacterium strain LB4404) and kanamycin (50 mg/L) at 28 °C for 48 hours. Abrobacterium colonies which developed on the selective media are analyzed by PCR using the primers which are designed to span the inserted sequence in the pPI plasmid. The resulting PCR products are isolated and sequenced as described in Example 3 30 above, to verify that the correct yield sequences are properly introduced to the Agrobacterium cells. 190 EXAMPLE 9

PRODUCING TRANSGENIC ARABIDOPSIS PLANTS EXPRESSING SELECTED GENES ACCORDING TO SOME EMBODIMENTS OF THE INVENTION

Materials and Experimental Methods

Plant transformation - The Arabidopsis thaliana var Columbia (T0 plants) were transformed according to the Floral Dip procedure [Clough SJ, Bent AF. (1998) Floral dip: a simplified method for Agrobacterium-mediated transformation of Arabidopsis thaliana. Plant J. 16(6): 735-43; and Desfeux C, Clough SJ, Bent AF. (2000) Female reproductive tissues are the primary targets of Agrobacterium-mediated transformation by the Arabidopsis floral-dip method. Plant Physiol. 123(3): 895-904] with minor modifications. Briefly, Arabidopsis thaliana Columbia (ColO) T0 plants were sown in 250 ml pots filled with wet peat-based growth mix. The pots were covered with aluminum foil and a plastic dome, kept at 4 °C for 3-4 days, then uncovered and incubated in a growth chamber at 18-24 °C under 16/8 hours light/dark cycles. The T0 plants were ready for transformation six days before anthesis.

Single colonies of Agrobacterium carrying the binary vectors harboring the yield genes were cultured in LB medium supplemented with kanamycin (50 mg/L) and gentamycin (50 mg/L). The cultures were incubated at 28 °C for 48 hours under vigorous shaking and centrifuged at 4000 rpm for 5 minutes. The pellets comprising Agrobacterium cells were resuspended in a transformation medium which contained half-strength (2.15 g/L) Murashige-Skoog (Duchefa); 0.044 μΜ benzylamino purine (Sigma); 112 μ g/L B5 Gambourg vitamins (Sigma); 5 % sucrose; and 0.2 ml/L Silwet L-77 (OSI Specialists, CT) in double-distilled water, at pH of 5.7.

Transformation of To plants was performed by inverting each plant into an Agrobacterium suspension such that the above ground plant tissue was submerged for 3-5 seconds. Each inoculated T0 plant was immediately placed in a plastic tray, then covered with clear plastic dome to maintain humidity and was kept in the dark at room temperature for 18 hours to facilitate infection and transformation. Transformed (transgenic) plants were then uncovered and transferred to a greenhouse for recovery and maturation. The transgenic To plants were grown in the greenhouse for 3-5 weeks until siliques were brown and dry, then seeds were harvested from plants and kept at room temperature until sowing. 191

For generating Τι and T2 transgenic plants harboring the genes, seeds collected from transgenic T0 plants were surface-sterilized by soaking in 70 % ethanol for 1 minute, followed by soaking in 5 % sodium hypochlorite and 0.05 % triton for 5 minutes. The surface-sterilized seeds were thoroughly washed in sterile distilled water then placed on culture plates containing half-strength Murashig-Skoog (Duchefa); 2 % sucrose; 0.8 % plant agar; 50 mM kanamycin; and 200 mM carbenicylin (Duchefa). The culture plates were incubated at 4 °C for 48 hours then transferred to a growth room at 25 °C for an additional week of incubation. Vital Ti Arabidopsis plants were transferred to a fresh culture plates for another week of incubation. Following incubation the T1 plants were removed from culture plates and planted in growth mix contained in 250 ml pots. The transgenic plants were allowed to grow in a greenhouse to maturity. Seeds harvested from Ti plants were cultured and grown to maturity as T2 plants under the same conditions as used for culturing and growing the T1 plants. EXAMPLE 10

IMPROVED TRANSGENIC PLANT PERFORMANCE - GREENHOUSE ASSAYS

To analyze the effect of expression of the isolated polynucleotides in plants, plants performance was tested under greenhouse conditions.

Greenhouse assays - The plants were analyzed for their overall size, growth rate, flowering, seed yield, weight of 1,000 seeds, dry matter and harvest index (HI-seed yield/dry matter). Transgenic plants performance was compared to control plants grown in parallel under the same conditions. Mock- transgenic plants expressing the uidA reporter gene (GUS-Intron) or with no gene at all, under the same promoter were used as control.

The experiment was planned in nested randomized plot distribution. For each gene of the invention three to five independent transformation events were analyzed from each construct. In cases where a certain event appears more than once, the event was tested in several independent experiments.

Tables 29 and 31 specify the parameters measured in plants in the greenhouse assays (till seed maturation and bolting assay, respectively).

Digital imaging - A laboratory image acquisition system, which consists of a digital reflex camera (Canon EOS 300D) attached with a 55 mm focal length lens 2016213786 11 Aug 2016 192 (Canon EF-S series), mounted on a reproduction device (Kaiser RS), which included 4 light units (4 x 150 Watts light bulb) is used for capturing images of plant samples.

The image capturing process was repeated every 2 days starting from day 1 after transplanting till day 16. Same camera, placed in a custom made iron mount, was used 5 for capturing images of larger plants sawn in white tubs in an environmental controlled greenhouse. The tubs were square shape include 1.7 liter trays. During the capture process, the tubs were placed beneath the iron mount, while avoiding direct sun light and casting of shadows.

An image analysis system was used, which consists of a personal desktop 10 computer (Intel P4 3.0 GHz processor) and a public domain program - ImageJ 1.39 (Java based image processing program which was developed at the U.S National Institutes of Health and freely available on the internet at Hypertext Transfer Protocol://rsbweb (dot) nih (dot) gov/). Images were captured in resolution of 10 Mega Pixels (3888 x 2592 pixels) and stored in a low compression JPEG (Joint Photographic 15 Experts Group standard) format. Next, analyzed data was saved to text files and processed using the JMP statistical analysis software (SAS institute).

Leaf growth analysis - Using the digital analysis leaves data was calculated, including leaf number, rosette area, rosette diameter, leaf blade area, plot coverage, leaf petiole length.

20 The vegetative growth rate of the plant was defined by formulas XIII, XIV, XV and XVI.

Formula XIII:

Relative growth rate of leaf blade area = Regression coefficient of leaf area along time course. 25 Formula XIV:

Relative growth rate of rosette area = Regression coefficient of rosette area along time course.

Formula XV

Relative growth rate of rosette diameter = Regression coefficient of rosette 30 diameter along time course. 2016213786 11 Aug 2016 193

Formula XVI

Relative growth rate of plot coverage = Regression coefficient of plot coverage along time course.

Seeds average weight (Seed weight or 1000 seed weight) - At the end of the 5 experiment all seeds were collected. The seeds were scattered on a glass tray and a picture was taken. Using the digital analysis, the number of seeds in each sample was calculated.

Plant dry weight and seed yield - On about day 80 from sowing, the plants were harvested and left to dry at 30 °C in a drying chamber. The biomass and seed weight of 10 each plot were measured and divided by the number of plants in each plot. Dry weight = total weight of the vegetative portion above ground (excluding roots) after drying at 30 °C in a drying chamber;

Seed yield per plant = total seed weight per plant (gr.). 1000 seed weight (the weight of 1000 seeds) (gr.). 15 The harvest index was calculated using Formula IV (Harvest Index = Average seed yield per plant/ Average dry weight) as described above.

Oil percentage in seeds - At the end of the experiment all seeds from plots A-C were collected. Columbia seeds from 3 plots were mixed grounded and then mounted onto the extraction chamber. 210 ml of n-Hexane (Cat No. 080951 Biolab Ltd.) were 20 used as the solvent. The extraction was performed for 30 hours at medium heat 50 °C. Once the extraction has ended the n-Hexane was evaporated using the evaporator at 35 °C and vacuum conditions. The process was repeated twice. The information gained from the Soxhlet extractor (Soxhlet, F. Die gewichtsanalytische Bestimmung des Milchfettes, Polytcchnisches J. (Dingler's) 1879, 232, 461) was used to create a 25 calibration curve for the Low Resonance NMR. The content of oil of all seed samples was determined using the Low Resonance NMR (MARAN Ultra- Oxford Instrument) and its MultiQuant sowftware package.

Oil yield - The oil yield was calculated using Formula IX (described above).

Silique length analysis - On day 50 from sowing, 30 siliques from different 30 plants in each plot were sampled in block A. The chosen siliques were green-yellow in color and were collected from the bottom parts of a grown plant’s stem. A digital photograph was taken to determine silique's length. 2016213786 11 Aug 2016 194

Statistical analyses - To identify genes conferring significantly improved tolerance to abiotic stresses, the results obtained from the transgenic plants were compared to those obtained from control plants. To identify outperforming genes and constructs, results from the independent transformation events tested were analyzed 5 separately. Data was analyzed using Student's t-test and results were considered significant if the p value was less than 0.1. The JMP statistics software package was used (Version 5.2.1, SAS Institute Inc., Cary, NC, USA).

Experimental Results

Plants expressing the polynucleotides of the some embodiments of the invention 10 were assayed for a number of commercially desired traits. In cases where a certain event appears more than once, the event was tested in several independent experiments.

Table 29

Measured parameters at the greenhouse till seed maturation assay (T2 experiment) 15 for transformed agriculture improving trait genes

Tested Parameters Id Dry Weight (gr) A Harvest Index B Leaf Blade Area TP4 (cm2) C Leaf Number TP4 D Leaf Petiole Length TP4 (cm) E Petiole Relative Area TP4 F Plot Coverage TP4 (cm2) G RGR Of Leaf Blade Area H RGR Of Plot Coverage I RGR Of Rosette Area J RGR Of Rosette Diameter K Rosette Area TP4 (cm2) L Rosette Diameter TP4 (cm) M Seed Yield (gr) N Seeds Weight (gr) 0 Blade Relative Area TP4 P Oil Content 0 RGR Of Leaf Number R Table 29: Provided are the identification (ID) letters of each of t ie Tested

Parameters. RGR-Relative Growth Rate; TP4- time point 4. 2016213786 11 Aug 2016 195

Table 30

Results obtained in a Greenhouse till seed maturation assay

Gene name Even t ID Mean P value % incr. vs. cont. Gene name Even t ID Mean P value % incr. vs. cont. LYM 16 1162 3.2 A 0.739 2.97E -02 10.4 LYM 9 1163 3.7 P 93.11 5 4.23E -03 3.2 LYM 57 1201 2.6 A 0.841 4.23E -02 25.7 LYM 15 1161 1.3 P 93.13 1 5.66E -03 3.2 LYM 17 1168 1.4 A 0.728 5.16E -02 8.8 LYM 4 1170 2.1 P 93.16 7 7.54E -03 3.2 LYM 10 1174 4.1 A 0.723 8.27E -02 8 LYM 17 1168 2.3 P 92.74 7 8.70E -03 2.8 LYM 95 1212 1.3 A 0.779 9.81E -02 16.5 LYM 17 1168 4.5 P 92.55 4 1.28E -02 2.6 CON TRO L — A 0.669 — 0 LYM 2 1169 1.2 P 92.87 5 1.35E -02 2.9 LYM 16 1162 3.5 B 0.543 6.50E -05 45.1 LYM 7 1159 4.3 P 92.51 3 1.79E -02 2.5 LYM 24 1206 3.3 B 0.515 2.78E -04 37.6 LYM 67 1178 2.5 P 94.03 7 1.83E -02 4.2 LYM 10 1174 1.4 B 0.499 3.74E -04 33.4 LYM 44 1188 4.3 P 92.30 6 2.09E -02 2.3 LYM 7 1159 4.2 B 0.498 1.10E -03 33.1 LYM 62 1202 2.4 P 92.29 6 2.21E -02 2.3 LYM 44 1188 5.3 B 0.473 1.50E -03 26.6 LYM 19 1175 1.4 P 92.24 4 2.38E -02 2.2 LYM 15 1161 1.3 B 0.477 3.91E -03 27.7 LYM 17 1168 4.4 P 92.43 8 3.04E -02 2.4 LYM 2 1169 5.1 B 0.457 4.23E -03 22.2 LYM 31 1192 3.1 P 92.39 9 3.32E -02 2.4 LYM 30 1191 3.3 B 0.462 4.25E -03 23.6 LYM 34 1190 3.3 P 92.07 3.49E -02 2 LYM 8 1198 4.1 B 0.472 4.44E -03 26.3 LYM 12 1187 1.3 P 91.99 9 3.94E -02 2 LYM 31 1192 3.1 B 0.471 4.64E -03 26 LYM 15 1161 4.3 P 91.99 6 5.05E -02 1.9 LYM 14 1205 1.1 B 0.454 5.37E -03 21.5 LYM 15 1161 4.4 P 91.87 7 5.09E -02 1.8 LYM 2 1169 2.3 B 0.546 5.62E -03 46 LYM 10 1174 1.4 P 91.97 9 5.99E -02 1.9 LYM 16 1162 4.6 B 0.468 8.76E -03 25.1 LYM 57 1201 2.4 P 91.75 2 6.64E -02 1.7 LYM 66 1195 4.4 B 0.455 9.16E -03 21.7 LYM 24 1206 3.3 P 92.88 3 6.73E -02 2.9 LYM 34 1190 4.3 B 0.442 1.1 IE -02 18.3 LYM 16 1162 4.6 P 91.72 3 7.65E -02 1.6 LYM 53 1184 3.2 B 0.506 1.24E -02 35.4 LYM 26 1182 4.3 P 91.67 2 7.95E -02 1.6 LYM 35 1181 2.4 B 0.446 1.49E -02 19.2 LYM 66 1195 5.2 P 91.69 3 8.09E -02 1.6 LYM 4 1170 6.5 B 0.456 1.57E -02 21.9 LYM 62 1202 3.7 P 92.17 8.37E -02 2.1 2016213786 11 Aug 2016 196 Gene name Even t ID Mean P value % incr. vs. cont. Gene name Even t ID Mean P value % incr. vs. cont. LYM 15 1161 2.2 B 0.437 1.59E -02 16.9 LYM 30 1191 3.3 P 91.63 7 8.66E -02 1.5 LYM 19 1175 4.1 B 0.448 1.60E -02 19.8 LYM 12 1187 3.4 P 91.84 9.17E -02 1.8 LYM 9 1163 4.6 B 0.466 1.61E -02 24.6 LYM 51 1189 1.1 P 92.63 9.56E -02 2.6 LYM 1 1160 1.1 B 0.465 1.63E -02 24.3 CON TRO L — P 90.23 9 — 0 LYM 57 1201 3.1 B 0.429 3.09E -02 14.8 LYM 17 1168 4.5 Q 31.92 5 1.22E -04 13.3 LYM 17 1168 4.5 B 0.501 3.38E -02 34.1 LYM 66 1195 2.1 Q 31.76 1.43E -04 12.7 LYM 30 1191 2.6 B 0.506 3.67E -02 35.3 LYM 34 1190 4.3 Q 31.58 5 2.06E -04 12.1 LYM 24 1206 1.2 B 0.481 4.69E -02 28.5 LYM 17 1168 2.3 Q 32.16 2.39E -04 14.1 LYM 82 1220 3.2 B 0.53 4.78E -02 41.7 LYM 82 1220 3.2 Q 31.18 5 4.56E -04 10.7 LYM 31 1192 4.4 B 0.437 4.78E -02 16.7 LYM 2 1169 2.3 Q 31.17 7.38E -04 10.6 LYM 6 1173 5.1 B 0.42 5.60E -02 12.3 LYM 14 1205 1.1 Q 30.42 5 2.85E -03 8 LYM 8 1198 3.1 B 0.47 6.47E -02 25.8 LYM 43 1179 1.2 Q 31.01 5 3.17E -03 10.1 LYM 6 1173 4.3 B 0.418 6.56E -02 11.9 LYM 43 1179 3.2 Q 31.92 4.77E -03 13.3 LYM 30 1191 2.7 B 0.512 6.75E -02 36.9 LYM 26 1182 4.3 Q 30.13 5.77E -03 6.9 LYM 26 1182 4.3 B 0.483 6.80E -02 29.2 LYM 51 1189 3.4 Q 30.12 7.02E -03 6.9 LYM 8 1198 2.4 B 0.475 7.82E -02 27.1 LYM 10 1174 1.4 Q 30.01 8.17E -03 6.5 LYM 12 1187 1.1 B 0.457 8.07E -02 22.2 LYM 22 1176 1.3 Q 30.89 5 8.20E -03 9.6 LYM 67 1178 2.6 B 0.49 8.15E -02 31.1 LYM 15 1161 1.3 Q 30.05 8.49E -03 6.6 LYM 22 1176 4.1 B 0.474 8.22E -02 26.8 LYM 24 1206 3.3 Q 30.21 5 1.03E -02 7.2 LYM 51 1189 3.4 B 0.476 8.62E -02 27.4 LYM 43 1179 2.2 Q 29.98 5 1.19E -02 6.4 LYM 21 1167 4.5 B 0.516 8.83E -02 38 LYM 62 1202 3.2 Q 29.85 5 1.23E -02 5.9 LYM 7 1159 4.3 B 0.464 8.85E -02 24 LYM 7 1159 1.5 Q 29.84 5 1.27E -02 5.9 LYM 24 1206 4.1 B 0.491 8.92E -02 31.2 LYM 66 1195 5.2 Q 30.36 5 1.58E -02 7.7 LYM 2 1169 1.2 B 0.454 9.14E -02 21.4 LYM 24 1206 1.2 Q 29.76 1.61E -02 5.6 LYM 13 1177 2.2 B 0.474 9.21E -02 26.9 LYM 69 1185 2.2 Q 29.82 1.91E -02 5.8 LYM 68 1194 2.3 B 0.426 9.22E -02 13.9 LYM 62 1202 3.7 Q 29.69 2.03E -02 5.3 2016213786 11 Aug 2016 197 Gene name Even t ID Mean P value % incr. vs. cont. Gene name Even t ID Mean P value % incr. vs. cont. LYM 44 1188 4.3 B 0.414 9.80E -02 10.6 LYM 17 1168 4.4 Q 29.68 2.16E -02 5.3 CON TRO L — B 0.374 — 0 LYM 7 1159 2.1 Q 31.66 3.45E -02 12.3 LYM 95 1212 1.3 C 0.73 2.06E -04 46.2 LYM 31 1192 3.1 Q 29.53 3.69E -02 4.8 LYM 10 1174 1.2 C 0.655 3.02E -03 31.2 LYM 53 1184 1.2 Q 30.06 3.89E -02 6.7 LYM 21 1167 1.2 C 0.619 4.67E -03 23.9 LYM 57 1201 2.6 Q 29.38 4.78E -02 4.2 LYM 62 1202 4.2 C 0.626 7.02E -03 25.3 LYM 66 1195 4.4 Q 31.52 5.68E -02 11.8 LYM 66 1195 3.1 C 0.602 1.02E -02 20.5 LYM 14 1205 2.4 Q 29.42 5.94E -02 4.4 LYM 10 1174 4.1 C 0.602 1.02E -02 20.5 LYM 51 1189 4.2 Q 30.18 5 6.04E -02 7.1 LYM 4 1170 6.5 C 0.575 3.74E -02 15.2 LYM 68 1194 1.3 Q 30.51 5 6.20E -02 8.3 LYM 44 1188 2.1 C 0.569 5.06E -02 13.9 LYM 8 1198 4.1 Q 29.39 5 6.25E -02 4.3 LYM 66 1195 5.2 C 0.586 5.09E -02 17.4 LYM 30 1191 2.6 Q 31.81 5 6.57E -02 12.9 LYM 82 1220 1.1 C 0.567 6.28E -02 13.6 LYM 13 1177 2.1 Q 29.53 8.65E -02 4.8 LYM 68 1194 1.4 C 0.564 6.49E -02 13.1 LYM 24 1206 4.1 Q 30.50 5 9.05E -02 8.2 LYM 95 1212 1.2 C 0.557 9.41E -02 11.6 LYM 44 1188 5.4 Q 29.57 9.26E -02 4.9 CON TRO L — C 0.499 — 0 LYM 1 1160 1.1 Q 29.68 5 9.43E -02 5.3 LYM 31 1192 3.1 D 9.125 4.78E -04 8.8 CON TRO L — Q 28.18 3 — 0 LYM 26 1182 4.6 D 8.938 4.23E -03 6.5 LYM 175 1265 1.6 A 1.514 2.92E -03 50.2 LYM 4 1170 5.2 D 8.938 4.23E -03 6.5 LYM 256 1332 1.2 A 1.169 5.61E -02 16 LYM 9 1163 2.1 D 8.938 4.23E -03 6.5 LYM 147 1258 1.4 A 1.154 6.79E -02 14.5 LYM 44 1188 2.1 D 8.875 4.88E -03 5.8 CON TRO L — A 1.008 — 0 LYM 8 1198 4.1 D 8.875 4.88E -03 5.8 LYM 207 1325 1.4 B 0.356 7.41E -02 8.2 LYM 4 1170 2.1 D 9.5 5.72E -03 13.3 LYM 73 1262 4.1 B 0.362 9.94E -02 9.9 LYM 10 1174 4.5 D 8.813 1.53E -02 5.1 CON TRO L — B 0.329 — 0 LYM 24 1206 1.1 D 8.813 1.53E -02 5.1 LYM 206 1260 1.3 C 0.313 3.92E -03 31.8 2016213786 11 Aug 2016 198 Gene name Even t ID Mean P value % incr. vs. cont. Gene name Even t ID Mean P value % incr. vs. cont. LYM 66 1195 2.1 D 8.75 1.97E -02 4.3 LYM 207 1325 1.4 C 0.281 2.47E -02 18.2 LYM 69 1185 1.2 D 8.75 1.97E -02 4.3 LYM 241 1327 1.2 c 0.291 3.27E -02 22.5 LYM 95 1212 1.3 D 8.75 1.97E -02 4.3 LYM 159 1335 4.5 c 0.272 4.39E -02 14.8 LYM 53 1184 2.4 D 9 3.32E -02 7.3 LYM 91 1328 3.1 c 0.268 7.20E -02 13 LYM 16 1162 3.2 D 8.875 6.05E -02 5.8 CON TRO L — c 0.237 — 0 LYM 37 1180 3.2 D 8.875 6.05E -02 5.8 LYM 175 1265 3.3 D 9 1.81E -02 3 LYM 57 1201 2.6 D 8.875 6.05E -02 5.8 LYM 206 1260 3.1 D 9 1.81E -02 3 LYM 15 1161 4.4 D 8.688 6.06E -02 3.6 LYM 147 1258 1.4 D 9.25 7.10E -02 5.9 LYM 43 1179 1.5 D 8.688 6.06E -02 3.6 LYM 147 1258 4.4 D 9.25 7.10E -02 5.9 LYM 44 1188 5.3 D 8.625 8.97E -02 2.8 CON TRO L — D 8.734 — 0 LYM 53 1184 4.2 D 8.625 8.97E -02 2.8 LYM 207 1325 1.4 E 0.494 2.25E -03 29 LYM 7 1159 4.3 D 8.625 8.97E -02 2.8 LYM 206 1260 1.3 E 0.49 3.51E -03 27.9 CON TRO L — D 8.388 — 0 LYM 91 1328 3.1 E 0.451 2.44E -02 17.8 LYM 95 1212 1.3 E 0.871 6.40E -05 20.5 CON TRO L — E 0.383 — 0 LYM 10 1174 1.2 E 0.854 1.68E -04 18 LYM 175 1265 1.6 F 8.457 9.98E -03 14.9 LYM 51 1189 3.4 E 0.814 1.64E -03 12.5 LYM 241 1327 1.2 F 7.999 8.84E -02 8.7 LYM 26 1182 4.1 E 0.864 3.71E -03 19.4 CON TRO L — F 7.36 — 0 LYM 16 1162 3.2 E 0.793 8.69E -03 9.6 LYM 241 1327 1.2 G 13.92 4 3.22E -02 20.3 LYM 12 1187 1.1 E 0.79 8.71E -03 9.2 LYM 256 1332 2.3 G 13.01 2 5.32E -02 12.5 LYM 41 1183 4.3 E 0.788 9.62E -03 9 LYM 91 1328 3.1 G 12.99 6 5.81E -02 12.3 LYM 44 1188 5.4 E 0.791 2.21E -02 9.3 CON TRO L — G 11.57 — 0 LYM 17 1168 1.4 E 0.788 2.38E -02 8.9 LYM 206 1260 1.3 H 0.038 9.68E -03 39.1 LYM 21 1167 3.1 E 0.822 2.48E -02 13.7 LYM 206 1260 2.1 H 0.037 3.48E -02 35.7 2016213786 11 Aug 2016 199 Gene name Even t ID Mean P value % incr. vs. cont. Gene name Even t ID Mean P value % incr. vs. cont. LYM 20 1171 1.1 E 0.786 4.67E -02 8.7 LYM 147 1258 4.4 H 0.036 4.44E -02 30.6 LYM 4 1170 6.5 E 0.818 5.29E -02 13.1 LYM 147 1258 3.3 H 0.035 4.93E -02 29.1 LYM 68 1194 2.3 E 0.786 6.52E -02 8.7 LYM 203 1266 4.1 H 0.035 7.71E -02 27.4 LYM 53 1184 1.1 E 0.823 9.25E -02 13.8 LYM 159 1335 4.6 H 0.035 8.34E -02 28.1 CON TRO L — E 0.723 — 0 LYM 241 1327 1.2 H 0.034 9.00E -02 24.6 LYM 34 1190 2.2 F 13.36 3 5.21E -03 33.8 CON TRO L — H 0.027 — 0 LYM 17 1168 1.4 F 11.76 4 3.07E -02 17.8 LYM 206 1260 1.3 I 1.904 2.91E -02 34.1 LYM 37 1180 2.2 F 11.83 9 5.95E -02 18.5 LYM 147 1258 3.3 I 1.834 5.96E -02 29.1 CON TRO L — F 9.989 — 0 LYM 147 1258 4.4 I 1.823 6.86E -02 28.3 LYM 21 1167 1.2 G 29.31 8 2.73E -03 29 CON TRO L — I 1.421 — 0 LYM 95 1212 1.3 G 35.39 8 5.12E -03 55.7 LYM 206 1260 1.3 J 0.238 2.91E -02 34.1 LYM 44 1188 2.1 G 28.41 9 6.04E -03 25 LYM 147 1258 3.3 J 0.229 5.96E -02 29.1 LYM 10 1174 1.2 G 31.63 6 7.14E -03 39.1 LYM 147 1258 4.4 J 0.228 6.86E -02 28.3 LYM 66 1195 3.1 G 28.02 8.78E -03 23.2 CON TRO L — J 0.178 — 0 LYM 4 1170 6.5 G 28.51 5 1.1 IE -02 25.4 LYM 206 1260 1.3 K 0.227 3.54E -02 26.3 LYM 62 1202 4.2 G 30.01 7 1.16E -02 32 LYM 203 1266 4.1 K 0.225 6.18E -02 25.1 LYM 66 1195 5.2 G 27.27 7 1.76E -02 20 LYM 159 1335 4.6 K 0.22 8.46E -02 22.6 LYM 68 1194 1.4 G 26.64 6 3.40E -02 17.2 LYM 206 1260 2.1 K 0.223 8.54E -02 24 LYM 82 1220 1.1 G 26.54 8 4.02E -02 16.8 LYM 241 1327 1.2 K 0.217 9.49E -02 21.1 LYM 9 1163 2.1 G 26.84 5 4.65E -02 18.1 CON TRO L — K 0.179 — 0 LYM 53 1184 1.1 G 28.48 2 7.52E -02 25.3 LYM 241 1327 1.2 L 1.74 3.22E -02 20.3 LYM 95 1212 1.2 G 26.98 6 9.98E -02 18.7 LYM 256 1332 2.3 L 1.627 5.32E -02 12.5 CON TRO L — G 22.73 5 — 0 LYM 91 1328 3.1 L 1.625 5.81E -02 12.3 2016213786 11 Aug 2016 200 Gene name Even t ID Mean P value % incr. vs. cont. Gene name Even t ID Mean P value % incr. vs. cont. LYM 95 1212 1.3 H 0.094 1.34E -02 47.3 CON TRO L — L 1.446 — 0 LYM 10 1174 1.2 H 0.084 7.76E -02 31.9 LYM 206 1260 1.3 M 2.453 2.09E -03 18 CON TRO L — H 0.064 — 0 LYM 241 1327 1.2 M 2.397 1.28E -02 15.3 LYM 95 1212 1.3 I 4.691 6.13E -03 54.8 LYM 207 1325 1.4 M 2.296 3.04E -02 10.4 LYM 10 1174 1.2 I 4.228 3.51E -02 39.5 LYM 147 1258 4.4 M 2.386 8.91E -02 14.8 LYM 62 1202 4.2 I 3.957 8.88E -02 30.6 LYM 256 1332 2.3 M 2.239 9.17E -02 7.7 LYM 10 1174 4.5 I 3.988 9.32E -02 31.6 CON TRO L — M 2.079 — 0 CON TRO L — I 3.03 — 0 LYM 236 1259 4.3 O 0.026 6.00E -02 15.3 LYM 95 1212 1.3 J 0.586 8.07E -03 52.2 LYM 147 1258 4.4 O 0.028 6.46E -02 22.5 LYM 10 1174 1.2 J 0.529 4.45E -02 37.2 CON TRO L — o 0.023 — 0 CON TRO L — J 0.385 — 0 LYM 157 1334 1.3 P 93.97 7 3.21E -02 2.1 LYM 95 1212 1.3 K 0.411 5.44E -03 28.5 LYM 256 1332 4.2 P 93.95 4 3.46E -02 2.1 LYM 10 1174 1.2 K 0.392 2.01E -02 22.4 LYM 159 1335 4.5 P 93.98 3 7.24E -02 2.1 LYM 10 1174 4.5 K 0.383 4.42E -02 19.7 LYM 223 1267 1.2 P 93.58 7 8.19E -02 1.7 LYM 10 1174 4.1 K 0.378 5.54E -02 18.2 LYM 157 1334 1.7 P 93.61 6 9.88E -02 1.7 LYM 26 1182 4.1 K 0.377 6.36E -02 17.6 CON TRO L — P 92.01 8 — 0 LYM 21 1167 1.2 K 0.377 6.69E -02 17.8 LYM 250 1261 3.4 Q 30.53 5 3.32E -03 7.9 LYM 68 1194 1.4 K 0.373 7.72E -02 16.6 LYM 206 1260 1.2 Q 29.68 5 1.79E -02 4.9 CON TRO L — K 0.32 — 0 LYM 147 1258 2.3 Q 29.84 3.32E -02 5.5 LYM 21 1167 1.2 L 3.665 3.75E -03 26.8 LYM 203 1266 2.3 Q 31.71 5 3.46E -02 12.1 LYM 95 1212 1.3 L 4.425 5.70E -03 53.1 LYM 157 1334 1.3 Q 29.42 4.35E -02 4 LYM 10 1174 1.2 L 3.954 8.47E -03 36.9 LYM 206 1260 3.2 Q 29.34 6.50E -02 3.7 2016213786 11 Aug 2016 201 Gene name Even t ID Mean P value % incr. vs. cont. Gene name Even t ID Mean P value % incr. vs. cont. LYM 44 1188 2.1 L 3.552 8.51E -03 22.9 LYM 91 1328 3.1 Q 29.24 5 7.37E -02 3.3 LYM 66 1195 3.1 L 3.502 1.25E -02 21.2 CON TRO L — Q 28.29 8 — 0 LYM 10 1174 4.1 L 3.498 1.28E -02 21.1 LYM 206 1260 3.1 R 0.682 1.24E -02 27.2 LYM 62 1202 4.2 L 3.752 1.43E -02 29.9 CON TRO L — R 0.536 — 0 LYM 4 1170 6.5 L 3.564 1.51E -02 23.4 LYM 113 1244 3.1 B 0.532 9.57E -03 25.9 LYM 66 1195 5.2 L 3.41 2.53E -02 18 LYM 267 1360 4.5 B 0.48 2.91E -02 13.6 LYM 68 1194 1.4 L 3.331 4.96E -02 15.3 LYM 285 1273 4.7 B 0.477 3.69E -02 12.8 LYM 82 1220 1.1 L 3.319 5.85E -02 14.8 LYM 113 1244 4.4 B 0.464 9.15E -02 9.7 LYM 9 1163 2.1 L 3.356 6.43E -02 16.1 CON TRO L — B 0.423 — 0 LYM 53 1184 1.1 L 3.56 8.80E -02 23.2 CON TRO L — E 0.515 — 0 CON TRO L — L 2.889 — 0 LYM 255 1308 1.5 F 8.406 9.80E -05 18.5 LYM 95 1212 1.3 M 3.993 1.50E -05 26.6 LYM 116 1320 4.6 F 7.893 5.11E -04 11.2 LYM 10 1174 1.2 M 3.71 3.24E -04 17.6 LYM 287 1277 1.6 F 7.885 5.55E -04 11.1 LYM 62 1202 4.2 M 3.594 1.18E -03 14 LYM 284 1288 4.6 F 7.834 7.75E -04 10.4 LYM 10 1174 4.1 M 3.58 1.97E -03 13.5 LYM 239 1304 1.7 F 7.666 3.45E -03 8 LYM 82 1220 1.1 M 3.499 8.49E -03 10.9 LYM 113 1244 4.5 F 8.133 6.77E -03 14.6 LYM 44 1188 5.4 M 3.407 2.47E -02 8 LYM 287 1277 1.7 F 7.628 7.48E -03 7.5 LYM 9 1163 2.1 M 3.475 2.70E -02 10.2 LYM 110 1292 3.5 F 8.115 1.19E -02 14.4 LYM 20 1171 1.1 M 3.387 2.94E -02 7.4 LYM 52 1289 5.7 F 7.749 1.33E -02 9.2 LYM 66 1195 3.1 M 3.494 3.07E -02 10.8 LYM 238 1276 4.8 F 8.587 4.56E -02 21 LYM 21 1167 3.1 M 3.421 3.23E -02 8.5 LYM 112 1337 4.4 F 7.715 6.97E -02 8.7 LYM 51 1189 3.4 M 3.481 3.65E -02 10.4 LYM 56 1311 2.5 F 7.798 9.00E -02 9.9 LYM 43 1179 2.2 M 3.43 5.63E -02 8.7 CON TRO L — F 7.096 — 0 2016213786 11 Aug 2016 202 Gene name Even t ID Mean P value % incr. vs. cont. Gene name Even t ID Mean P value % incr. vs. cont. LYM 26 1182 4.1 M 3.537 6.22E -02 12.1 LYM 56 1311 1.7 N 0.554 7.80E -02 10.8 LYM 17 1168 2.3 M 3.353 6.60E -02 6.3 CON TRO L — N 0.5 — 0 LYM 16 1162 3.2 M 3.512 6.70E -02 11.3 LYM 255 1308 2.9 O 0.025 3.34E -02 7.8 LYM 66 1195 5.2 M 3.419 8.25E -02 8.4 LYM 141 1240 2.4 O 0.027 3.92E -02 19.5 LYM 17 1168 1.4 M 3.326 8.35E -02 5.5 LYM 113 1244 2.1 o 0.025 4.02E -02 7.8 LYM 41 1183 4.3 M 3.318 9.59E -02 5.2 CON TRO L — o 0.023 — 0 LYM 21 1167 1.2 M 3.649 9.83E -02 15.7 LYM 181 1357 2.2 P 95.24 7 4.17E -02 1.9 CON TRO L — M 3.154 — 0 LYM 239 1304 4.9 P 95.31 7 9.21E -02 2 LYM 66 1195 4.4 N 0.311 2.80E -03 25.1 LYM 232 1302 3.6 P 93.97 6 9.43E -02 0.6 LYM 31 1192 3.1 N 0.302 5.66E -03 21.3 LYM 156 1296 3.5 P 94.45 2 9.56E -02 1.1 LYM 8 1198 2.4 N 0.301 5.78E -03 21.2 CON TRO L — P 93.44 1 — 0 LYM 17 1168 3.1 N 0.296 1.02E -02 18.9 LYM 255 1308 2.9 Q 34.41 5 9.06E -03 8.2 LYM 7 1159 4.3 N 0.284 4.39E -02 14 LYM 112 1337 2.3 Q 34.23 1.03E -02 7.6 LYM 57 1201 2.6 N 0.285 5.22E -02 14.6 LYM 196 1361 3.1 Q 33.73 5 3.50E -02 6.1 LYM 17 1168 4.5 N 0.277 8.28E -02 11.1 LYM 121 1321 1.8 Q 33.46 7.26E -02 5.2 LYM 13 1177 2.2 N 0.311 9.17E -02 25.1 LYM 287 1277 1.7 Q 33.23 7.99E -02 4.5 CON TRO L — N 0.249 — 0 LYM 56 1311 1.7 Q 33.21 8.34E -02 4.4 LYM 12 1187 2.1 O 0.024 1.60E -05 19.6 LYM 156 1296 3.3 Q 33.4 9.09E -02 5 LYM 22 1176 2.1 O 0.022 4.50E -05 13.3 LYM 238 1276 1.6 Q 34.2 9.81E -02 7.5 LYM 43 1179 2.2 o 0.026 4.80E -05 33.1 CON TRO L — Q 31.80 9 — 0 LYM 31 1192 3.4 o 0.022 1.05E -04 12.1 LYM 43 1179 1.2 o 0.022 1.77E -04 11.2 LYM 53 1184 1.1 o 0.022 3.43E -04 10 2016213786 11 Aug 2016 203 Gene name Even t ID Mean P value % incr. vs. cont. Gene name Even t ID Mean P value % incr. vs. cont. LYM 95 1212 1.3 O 0.026 3.71E -04 33.1 LYM 95 1212 1.2 o 0.023 3.96E -04 14.5 LYM 10 1174 4.1 o 0.023 2.55E -03 15.8 LYM 4 1170 2.1 o 0.021 3.43E -03 8.2 LYM 82 1220 4.6 o 0.021 4.85E -03 6.4 LYM 82 1220 4.2 o 0.021 6.10E -03 6.4 LYM 34 1190 4.3 o 0.021 6.18E -03 6.7 LYM 14 1205 4.2 o 0.021 1.02E -02 5.5 LYM 66 1195 4.4 o 0.023 3.15E -02 14.6 LYM 6 1173 4.3 o 0.024 6.98E -02 22.1 LYM 16 1162 3.2 o 0.023 7.55E -02 15.8 LYM 82 1220 1.1 o 0.024 9.20E -02 21.9 CON TRO L — o 0.02 — 0 Table 30. Results of the greenhouse experiments. Provided are the measured values of each tested parameter [parameters (ID.) A-P according to the parameters described in Table 29 above] in plants expressing the indicated polynucleotides. “Ev” = event; “P” = P-value; “Mean ” = the average of measured parameter across replicates. % incr. vs. cont. = percentage of increase versus control (as compared to control). 5

Table 31 10 Measured parameters at the greenhouse till bolting assay (T2 experiment) for transformed agriculture improving trait genes Tested Parameters ID Blade Relative Area TP4 A Dry Weight (gr) B Fresh Weight (gr) C Leaf Blade Area TP4 (cm2) D Leaf Number TP4 E Leaf Petiole Length TP4 (cm) F Petiole Relative Area TP4 G Plot Coverage TP4 (cm2) H RGR Of Leaf Blade Area J RGR Of Leaf Number K 2016213786 11 Aug 2016 204 Tested Parameters ID RGR Of Plot Coverage L RGR Of Rosette Area M RGR Of Rosette Diameter N Rosette Area TP4 (cm2) O Rosette Diameter TP4 (cm) P Table 31: Provided are the identification (ID) letters of each of the Tested Parameters. TP4-time Point 4; RGR - Relative Growth Rate.

Table 32 5 Results obtained in a T2 experiment at the bolting assay Gene name Event I D Mea n P value % incr. vs. cent. Gene name Event I D Mea n P value % incr. vs. cent. LYM14 12052. 5 A 92.4 05 3.09E- 03 2.5 LYM31 11923. 4 F 0.48 9 1.69E- 04 26.4 LYM62 12022. 4 A 92.3 49 4.28E- 03 2.5 LYM11 6 13202. 12 F 0.47 9 5.48E- 04 23.8 LYM20 11712. 2 A 92.8 93 5.39E- 03 3.1 LYM23 8 12764. 8 F 0.45 9 1.64E- 03 18.6 LYM24 12064. 1 A 92.3 39 6.75E- 03 2.5 LYM20 11711. 2 F 0.45 8 1.80E- 03 18.5 LYM57 12012. 2 A 92.2 51 6.81E- 03 2.4 LYM67 11782. 6 F 0.45 5 2.14E- 03 17.7 LYM2 11695. 1 A 92.1 21 7.11E- 03 2.2 LYM88 12193. 1 F 0.49 4 2.43E- 03 27.7 LYM15 11612. 2 A 94.3 48 1.01E- 02 4.7 LYM99 12244. 2 F 0.45 3.75E- 03 16.4 LYM21 11672. 4 A 92.4 04 1.14E- 02 2.5 LYM23 9 13044. 8 F 0.44 1 9.74E- 03 13.9 LYM19 11751. 4 A 91.8 36 1.32E- 02 1.9 LYM24 12061. 4 F 0.43 5 1.27E- 02 12.5 LYM53 11844. 2 A 91.8 22 1.53E- 02 1.9 LYM53 11841. 1 F 0.43 4 1.43E- 02 12.2 LYM12 11871. 1 A 92.9 49 1.90E- 02 3.2 LYM82 12201. 1 F 0.45 4 1.47E- 02 17.4 LYM17 11683. 1 A 92.2 67 2.24E- 02 2.4 LYM26 11824. 1 F 0.46 3.65E- 02 18.9 LYM57 12012. 4 A 91.6 37 2.27E- 02 1.7 LYM30 11912. 6 F 0.43 3 4.15E- 02 12 LYM51 11891. 1 A 91.8 13 2.38E- 02 1.9 LYM26 11824. 3 F 0.43 6 4.37E- 02 12.7 LYM41 11832. 2 A 91.5 78 2.83E- 02 1.6 LYM28 5 12733. 9 F 0.51 8 4.87E- 02 34 LYM19 11753. 1 A 91.9 58 3.26E- 02 2.1 LYM62 12023. 2 F 0.44 5 6.80E- 02 15.1 LYM51 11893. 4 A 91.5 04 3.29E- 02 1.5 LYM99 12243. 2 F 0.41 8 7.28E- 02 7.9 LYM35 11812. 3 A 91.4 89 3.40E- 02 1.5 LYM12 8 12641. 5 F 0.54 6 8.57E- 02 41 LYM2 11695. 3 A 91.5 33 5.57E- 02 1.6 LYM95 12121. 2 F 0.51 2 1.12E- 01 32.3 LYM34 11903. 2 A 91.7 66 6.00E- 02 1.8 LYM66 11953. 6 F 0.42 7 1.18E- 01 10.3 2016213786 11 Aug 2016 205 Gene name Event I D Mea n P value % incr. vs. cont. Gene name Event I D Mea n P value % incr. vs. cont. LYM37 11802. 2 A 92.4 9 7.93E- 02 2.6 LYM23 9 13042. 9 F 0.43 1 1.30E- 01 11.4 LYM10 11742. 2 A 91.5 36 7.98E- 02 1.6 LYM12 11872. 1 F 0.54 8 1.47E- 01 41.7 LYM31 11923. 4 A 91.4 74 8.92E- 02 1.5 LYM12 8 12641. 3 F 0.40 9 1.66E- 01 5.8 LYM30 11912. 7 A 91.1 22 9.52E- 02 1.1 LYM99 12243. 1 F 0.55 4 1.68E- 01 43.1 LYM9 11632. 1 A 91.3 52 1.07E- 01 1.4 LYM66 11954. 4 F 0.48 3 1.83E- 01 24.8 LYM26 11824. 6 A 91.0 76 1.19E- 01 1.1 LYM23 2 13024. 6 F 0.42 1.96E- 01 8.6 LYM57 12012. 6 A 91.0 44 1.24E- 01 1 LYM26 11824. 6 F 0.42 9 2.22E- 01 10.8 LYM16 11623. 2 A 92.1 18 1.47E- 01 2.2 LYM43 11791. 4 F 0.41 2.43E- 01 5.9 LYM69 11854. 2 A 92.1 15 1.61E- 01 2.2 LYM12 11873. 4 F 0.46 2 2.56E- 01 19.5 LYM57 12013. 1 A 91.8 86 1.66E- 01 2 LYM10 3 12713. 5 F 0.44 4 3.55E- 01 14.8 LYM15 11613. 3 A 91.9 04 1.68E- 01 2 LYM53 11842. 4 F 0.41 1 3.55E- 01 6.3 LYM20 11711. 3 A 91.6 69 1.89E- 01 1.7 LYM28 5 12734. 9 F 0.45 6 4.57E- 01 18 LYM41 11833. 1 A 91.3 84 1.92E- 01 1.4 LYM12 11871. 1 F 0.44 8 4.60E- 01 15.7 LYM67 11783. 5 A 91.0 23 1.94E- 01 1 LYM12 8 12641. 1 F 0.40 7 5.45E- 01 5.2 LYM22 11764. 1 A 90.8 53 2.00E- 01 0.8 LYM30 11913. 4 F 0.39 7 5.70E- 01 2.6 LYM69 11851. 2 A 91.7 4 2.05E- 01 1.8 LYM69 11852. 2 F 0.41 1 5.90E- 01 6.2 LYM66 11953. 1 A 92.2 57 2.06E- 01 2.4 LYM95 12124. 4 F 0.42 5 6.13E- 01 9.9 LYM26 11822. 5 A 91.0 28 2.12E- 01 1 LYM43 11793. 2 F 0.42 1 6.52E- 01 8.9 LYM30 11912. 6 A 90.8 41 2.14E- 01 0.8 LYM14 12051. 4 F 0.40 8 6.57E- 01 5.6 LYM31 11924. 4 A 91.9 21 2.30E- 01 2 LYM23 2 13024. 7 F 0.43 5 6.69E- 01 12.5 LYM4 11701. 1 A 91.7 54 2.39E- 01 1.8 LYM24 12064. 1 F 0.41 6 7.26E- 01 7.6 LYM14 12051. 4 A 90.8 3 2.43E- 01 0.8 LYM67 11782. 4 F 0.41 6 7.28E- 01 7.6 LYM67 11782. 6 A 91.4 69 2.52E- 01 1.5 LYM30 11913. 5 F 0.40 3 7.37E- 01 4.3 LYM62 12023. 2 A 91.7 52 2.52E- 01 1.8 LYM43 11791. 5 F 0.39 7 7.38E- 01 2.6 LYM57 12013. 5 A 91.6 99 2.60E- 01 1.8 LYM14 5 12951. 9 F 0.39 4 7.61E- 01 1.9 LYM68 11942. 2 A 90.9 59 2.62E- 01 0.9 LYM30 11912. 7 F 0.4 7.69E- 01 3.4 2016213786 11 Aug 2016 206 Gene name Event I D Mea n P value % incr. vs. cont. Gene name Event I D Mea n P value % incr. vs. cont. LYM19 11752. 2 A 91.0 8 2.63E- 01 1.1 LYM31 11924. 4 F 0.40 7 7.75E- 01 5.2 LYM44 11884. 1 A 91.1 09 2.88E- 01 1.1 LYM99 12244. 1 F 0.40 2 7.94E- 01 3.8 LYM53 11841. 1 A 92.2 8 2.88E- 01 2.4 LYM26 11824. 5 F 0.40 6 8.37E- 01 5 LYM69 11852. 2 A 91.9 59 2.91E- 01 2.1 LYM20 11716. 5 F 0.39 5 8.66E- 01 2.1 LYM31 11923. 1 A 90.8 76 2.91E- 01 0.9 LYM66 11955. 2 F 0.39 2 8.71E- 01 1.4 LYM66 11955. 2 A 92.7 03 2.94E- 01 2.9 LYM53 11843. 2 F 0.39 4 8.94E- 01 1.8 LYM1 11603. 2 A 92.0 51 3.02E- 01 2.2 LYM23 2 13024. 4 F 0.39 7 9.29E- 01 2.6 LYM41 11831. 5 A 91.8 26 3.07E- 01 1.9 LYM15 6 12963. 1 F 0.38 9 9.65E- 01 0.6 LYM20 11711. 2 A 90.8 81 3.47E- 01 0.9 LYM88 12194. 2 F 0.38 7 9.95E- 01 0.1 LYM13 11771. 6 A 90.6 5 3.62E- 01 0.6 CONTR OL _ F 0.38 7 _ 0 LYM67 11781. 5 A 90.9 95 3.69E- 01 1 LYM88 12193. 1 G 8.06 6 2.50E- 05 25.2 LYM2 11691. 2 A 91.3 85 3.77E- 01 1.4 LYM23 2 13024. 4 G 7.58 9 2.58E- 04 17.8 LYM30 11913. 4 A 90.8 53 3.81E- 01 0.8 LYM99 12244. 2 G 7.54 9 3.29E- 04 17.2 LYM1 11601. 1 A 90.8 59 3.94E- 01 0.8 LYM88 12191. 2 G 7.73 6 2.37E- 03 20.1 LYM10 11741. 2 A 91.0 19 3.97E- 01 1 LYM62 12023. 2 G 7.93 2 2.88E- 03 23.1 LYM24 12061. 1 A 91.6 43 3.97E- 01 1.7 LYM30 11912. 6 G 7.21 5 4.09E- 03 12 LYM13 11772. 1 A 91.7 42 4.02E- 01 1.8 LYM12 8 12641. 5 G 7.22 8 5.32E- 03 12.2 LYM14 12051. 1 A 90.7 81 4.03E- 01 0.7 LYM11 6 13204. 4 G 7.07 5 8.47E- 03 9.8 LYM4 11705. 2 A 92.1 32 4.20E- 01 2.2 LYM82 12201. 1 G 7.08 4 8.81E- 03 9.9 LYM17 11682. 1 A 92.4 67 4.22E- 01 2.6 LYM69 11852. 2 G 7.05 5 9.96E- 03 9.5 LYM1 11604. 4 A 91.8 03 4.50E- 01 1.9 LYM66 11953. 1 G 7.11 8 1.07E- 02 10.5 LYM8 11982. 4 A 91.7 23 4.54E- 01 1.8 LYM53 11844. 2 G 7.00 5 1.48E- 02 8.7 LYM34 11902. 2 A 91.3 34 4.56E- 01 1.4 LYM57 12012. 6 G 7.01 4 1.54E- 02 8.9 LYM43 11793. 2 A 91.5 34 4.59E- 01 1.6 LYM23 8 12764. 8 G 7.25 1 2.21E- 02 12.5 LYM51 11894. 2 A 91.5 83 4.61E- 01 1.6 LYM31 11921. 3 G 6.95 5 2.21E- 02 7.9 LYM21 11674. 5 A 90.7 03 4.62E- 01 0.7 LYM30 11913. 5 G 7.74 2 2.81E- 02 20.2 2016213786 11 Aug 2016 207 Gene name Event I D Mea n P value % incr. vs. cont. Gene name Event I D Mea n P value % incr. vs. cont. LYM69 11853. 4 A 91.0 48 5.05E- 01 1 LYM43 11791. 5 G 7.09 3 2.87E- 02 10.1 LYM12 11874. 1 A 90.8 63 5.30E- 01 0.8 LYM53 11842. 4 G 7.51 7 3.17E- 02 16.7 LYM44 11885. 3 A 91.4 11 5.42E- 01 1.4 LYM99 12244. 1 G 6.95 2 3.21E- 02 7.9 LYM12 11872. 1 A 91.4 94 5.47E- 01 1.5 LYM15 6 12963. 1 G 6.88 6 3.95E- 02 6.9 LYM9 11633. 7 A 90.8 19 5.50E- 01 0.8 LYM41 11831. 1 G 7 4.82E- 02 8.6 LYM13 11772. 2 A 91.5 48 5.65E- 01 1.6 LYM31 11923. 4 G 7.55 1 4.93E- 02 17.2 LYM34 11903. 3 A 91.3 19 5.74E- 01 1.3 LYM27 1 12724. 9 G 6.86 4 5.02E- 02 6.5 LYM67 11782. 5 A 90.9 78 5.82E- 01 1 LYM95 12124. 4 G 6.87 3 5.19E- 02 6.7 LYM51 11893. 2 A 90.8 2 5.94E- 01 0.8 LYM82 12204. 2 G 7.05 2 1.10E-01 9.4 LYM15 11611. 3 A 90.3 87 6.12E- 01 0.3 LYM12 5 12932. 6 G 6.75 2 1.22E- 01 4.8 LYM12 11874. 3 A 90.4 71 6.22E- 01 0.4 LYM12 11872. 1 G 7.49 9 1.25E- 01 16.4 LYM13 11771. 9 A 90.4 21 6.27E- 01 0.3 LYM12 1 13214. 5 G 6.73 7 1.37E- 01 4.6 LYM62 12022. 2 A 90.9 02 6.52E- 01 0.9 LYM23 9 13042. 9 G 6.75 1.43E- 01 4.8 LYM41 11834. 2 A 90.9 79 6.83E- 01 1 LYM66 11954. 4 G 6.90 2 1.52E- 01 7.1 LYM19 11751. 5 A 91.1 21 6.90E- 01 1.1 LYM51 11894. 2 G 7.54 1.56E- 01 17 LYM35 11813. 5 A 90.6 06 7.22E- 01 0.6 LYM28 5 12734. 9 G 8.17 9 1.81E- 01 26.9 LYM22 11762. 2 A 90.4 75 7.23E- 01 0.4 LYM12 8 12641. 4 G 6.70 2 1.87E- 01 4 LYM16 11622. 4 A 90.5 91 7.35E- 01 0.5 LYM57 12012. 4 G 6.72 5 1.88E- 01 4.4 LYM67 11783. 4 A 90.5 78 7.36E- 01 0.5 LYM14 12052. 5 G 7.47 2 1.90E- 01 16 LYM17 11684. 4 A 90.5 39 7.37E- 01 0.5 LYM23 9 13044. 8 G 7.08 7 1.96E- 01 10 LYM41 11831. 1 A 90.5 19 7.60E- 01 0.5 LYM43 11791. 4 G 8.56 7 2.01E- 01 33 LYM9 11633. 2 A 90.3 43 7.61E- 01 0.3 LYM12 1 13212. 6 G 7.74 6 2.15E- 01 20.2 LYM14 12052. 4 A 90.5 86 7.64E- 01 0.5 LYM99 12243. 1 G 7.93 5 2.19E- 01 23.1 LYM43 11792. 2 A 90.6 7 7.75E- 01 0.6 LYM62 12022. 4 G 7.20 9 2.28E- 01 11.9 LYM66 11953. 6 A 90.6 49 7.76E- 01 0.6 LYM56 13112. 6 G 7.56 7 2.56E- 01 17.4 LYM20 11716. 5 A 90.5 96 7.79E- 01 0.5 LYM14 12054. 2 G 7.74 7 2.74E- 01 20.2 2016213786 11 Aug 2016 208 Gene name Event I D Mea n P value % incr. vs. cont. Gene name Event I D Mea n P value % incr. vs. cont. LYM37 11803. 1 A 90.3 46 8.10E- 01 0.3 LYM69 11853. 4 G 7.20 1 3.46E- 01 11.8 LYM30 11913. 5 A 90.5 39 8.10E- 01 0.5 LYM12 11873. 4 G 8.01 6 3.55E- 01 24.4 LYM21 11673. 1 A 90.5 85 8.23E- 01 0.5 LYM51 11891. 1 G 7.38 6 3.60E- 01 14.6 LYM17 11684. 5 A 90.7 47 8.33E- 01 0.7 LYM95 12121. 2 G 6.91 2 3.61E- 01 7.3 LYM34 11904. 3 A 90.4 07 8.52E- 01 0.3 LYM14 5 12952. 9 G 7.17 3.74E- 01 11.3 LYM24 12063. 3 A 90.6 82 8.56E- 01 0.6 LYM28 4 12884. 7 G 6.91 3.81E- 01 7.2 LYM2 11692. 3 A 90.2 03 8.71E- 01 0.1 LYM53 11841. 2 G 7.39 3.85E- 01 14.7 LYM24 12062. 3 A 90.6 8.81E- 01 0.5 LYM23 8 12762. 8 G 7.07 5 3.94E- 01 9.8 LYM22 11762. 1 A 90.2 01 8.83E- 01 0.1 LYM62 12022. 1 G 7.52 5 3.95E- 01 16.8 LYM37 11803. 2 A 90.2 44 9.04E- 01 0.2 LYM43 11791. 2 G 7.70 3 4.20E- 01 19.5 LYM62 12022. 1 A 90.2 33 9.15E- 01 0.1 LYM51 11893. 4 G 7.27 2 4.52E- 01 12.9 LYM51 11892. 1 A 90.1 54 9.39E- 01 0.1 LYM15 6 12961. 9 G 6.67 7 4.65E- 01 3.6 LYM10 11744. 1 A 90.1 87 9.50E- 01 0.1 LYM31 11922. 3 G 6.66 1 4.71E- 01 3.4 LYM68 11941. 4 A 90.1 63 9.56E- 01 0.1 LYM43 11793. 2 G 7.39 3 4.87E- 01 14.7 LYM17 11683. 3 A 90.1 95 9.65E- 01 0.1 LYM23 2 13024. 6 G 6.59 6 4.89E- 01 2.4 LYM9 11632. 2 A 90.1 28 9.71E- 01 0 LYM23 2 13024. 5 G 6.73 2 4.92E- 01 4.5 LYM19 11754. 1 A 90.1 18 9.95E- 01 0 LYM14 5 12954. 7 G 6.58 4.97E- 01 2.1 CONTR OL _ A 90.1 08 _ 0 LYM41 11833. 1 G 6.86 5 5.04E- 01 6.5 LYM14 12051. 4 B 0.21 1 5.89E- 03 26.4 LYM12 8 12641. 1 G 6.79 6 5.07E- 01 5.5 LYM10 11744. 1 B 0.2 1.92E- 02 20 LYM14 12051. 1 G 6.80 8 5.14E- 01 5.7 LYM34 11902. 2 B 0.19 2 6.57E- 02 15.1 LYM53 11841. 1 G 6.94 7 5.15E- 01 7.8 LYM9 11632. 1 B 0.19 1 7.00E- 02 14.4 LYM88 12194. 2 G 6.86 4 5.26E- 01 6.5 LYM2 11695. 1 B 0.18 8 1.04E- 01 12.5 LYM24 12061. 4 G 6.84 2 5.31E- 01 6.2 LYM57 12013. 1 B 0.18 8 1.04E- 01 12.5 LYM62 12023. 4 G 7.30 8 5.31E- 01 13.4 LYM66 11954. 4 B 0.19 1 1.36E- 01 14.4 LYM51 11893. 2 G 6.68 9 5.34E- 01 3.8 LYM57 12012. 4 B 0.19 1 1.42E- 01 14.7 LYM57 12012. 2 G 6.68 6 5.42E- 01 3.8 2016213786 11 Aug 2016 209 Gene name Event I D Mea n P value % incr. vs. cont. Gene name Event I D Mea n P value % incr. vs. cont. LYM66 11953. 6 B 0.18 6 1.65E- 01 11.7 LYM30 11912. 7 G 6.94 9 5.55E- 01 7.8 LYM37 11803. 1 B 0.18 3 1.75E- 01 10.1 LYM66 11953. 6 G 6.63 2 5.60E- 01 2.9 LYM53 11844. 2 B 0.18 4 1.80E- 01 10.2 LYM53 11843. 2 G 6.95 9 5.75E- 01 8 LYM9 11632. 2 B 0.18 6 1.90E- 01 11.4 LYM56 13111. 7 G 7.26 8 5.80E- 01 12.8 LYM35 11812. 3 B 0.18 9 2.46E- 01 13.2 LYM67 11783. 5 G 6.72 4 5.88E- 01 4.4 LYM4 11701. 1 B 0.18 4 2.47E- 01 10.2 LYM95 12124. 5 G 6.84 9 6.12E- 01 6.3 LYM31 11924. 4 B 0.18 1 2.72E- 01 8.4 LYM31 11924. 4 G 6.59 7 6.17E- 01 2.4 LYM35 11813. 5 B 0.21 9 2.93E- 01 31.2 LYM41 11832. 2 G 6.53 3 6.27E- 01 1.4 LYM57 12012. 6 B 0.18 7 2.98E- 01 12.1 LYM51 11892. 1 G 6.97 8 6.31E- 01 8.3 LYM1 11604. 4 B 0.18 4 3.17E- 01 10.6 LYM43 11792. 2 G 6.78 2 6.47E- 01 5.2 LYM14 12051. 1 B 0.18 3.27E- 01 8 LYM28 5 12734. 7 G 7.28 4 6.55E- 01 13 LYM30 11912. 6 B 0.19 1 3.85E- 01 14.3 LYM27 1 12721. 8 G 6.63 7 6.59E- 01 3 LYM13 11771. 6 B 0.20 8 4.16E- 01 24.9 LYM30 11913. 4 G 7.07 6.73E- 01 9.7 LYM13 11771. 9 B 0.19 2 4.37E- 01 15.1 LYM31 11923. 1 G 6.85 4 6.88E- 01 6.4 LYM31 11923. 1 B 0.17 6 4.57E- 01 5.4 LYM82 12203. 2 G 6.63 5 7.11E- 01 3 LYM67 11783. 5 B 0.17 8 4.69E- 01 6.9 LYM20 11716. 3 G 6.74 7.14E- 01 4.6 LYM10 11741. 2 B 0.17 7 5.16E- 01 6.1 LYM23 9 13041. 7 G 6.70 9 7.58E- 01 4.1 LYM21 11673. 1 B 0.17 6 5.27E- 01 5.7 LYM24 12064. 1 G 6.57 3 7.64E- 01 2 LYM69 11851. 2 B 0.17 8 5.36E- 01 6.5 LYM23 9 13044. 7 G 6.62 9 7.70E- 01 2.9 LYM69 11852. 2 B 0.17 9 5.45E- 01 7.6 LYM88 12193. 5 G 6.59 5 7.72E- 01 2.4 LYM1 11603. 2 B 0.17 3 6.15E- 01 3.5 LYM20 11712. 2 G 6.61 6 7.87E- 01 2.7 LYM7 11594. 2 B 0.18 4 6.18E- 01 10.2 LYM62 12022. 2 G 6.61 2 7.91E- 01 2.6 LYM34 11903. 2 B 0.18 8 6.33E- 01 12.9 LYM67 11782. 6 G 6.50 9 7.99E- 01 1 LYM21 11674. 5 B 0.17 2 6.73E- 01 3.1 LYM20 11716. 5 G 6.54 1 8.15E- 01 1.5 LYM68 11942. 3 B 0.17 6 6.91E- 01 5.7 LYM23 2 13024. 7 G 6.66 3 8.27E- 01 3.4 LYM14 12054. 2 B 0.17 6 7.18E- 01 5.4 LYM26 11824. 1 G 6.55 8 8.57E- 01 1.8 2016213786 11 Aug 2016 210 Gene name Event I D Mea n P value % incr. vs. cont. Gene name Event I D Mea n P value % incr. vs. cont. LYM30 11913. 4 B 0.17 6 7.18E- 01 5.4 LYM99 12243. 2 G 6.51 2 8.64E- 01 1.1 LYM51 11893. 2 B 0.17 1 7.40E- 01 2.4 LYM12 1 13211. 8 G 6.51 1 8.82E- 01 1 LYM53 11842. 4 B 0.18 2 7.45E- 01 9.1 LYM99 12241. 1 G 6.50 3 8.85E- 01 0.9 LYM44 11884. 3 B 0.17 1 8.45E- 01 2.4 LYM14 12051. 4 G 6.46 8 8.96E- 01 0.4 LYM17 11683. 3 B 0.16 9 8.75E- 01 1.2 LYM67 11782. 4 G 6.53 6 9.09E- 01 1.4 LYM15 11611. 3 B 0.16 8 9.01E- 01 0.9 LYM26 11824. 5 G 6.46 9 9.55E- 01 0.4 LYM8 11982. 7 B 0.16 9 9.10E- 01 1.2 LYM26 11824. 3 G 6.47 5 9.58E- 01 0.5 LYM12 11872. 1 B 0.16 9 9.21E- 01 1.6 LYM95 12121. 4 G 6.45 8 9.88E- 01 0.2 LYM51 11893. 4 B 0.16 9 9.25E- 01 1.6 LYM24 12062. 3 G 6.45 7 9.90E- 01 0.2 LYM34 11903. 3 B 0.16 8 9.59E- 01 0.5 LYM23 9 13041. 1 G 6.44 8 9.93E- 01 0.1 LYM7 11592. 1 B 0.16 8 9.67E- 01 0.5 LYM12 11871. 1 G 6.44 5 9.94E- 01 0 CONTR OL _ B 0.16 7 _ 0 CONTR OL _ G 6.44 4 _ 0 LYM10 11744. 1 C 2.88 1 4.60E- 03 21 LYM11 6 13202. 12 H 18.3 12 4.00E- 06 47.5 LYM35 11813. 5 C 2.85 6.51E- 03 19.7 LYM88 12193. 1 H 15.6 81 1.86E- 04 26.3 LYM9 11632. 1 C 2.85 6.67E- 03 19.7 LYM31 11923. 4 H 14.8 37 1.11E- 03 19.5 LYM57 12013. 1 C 2.73 8 2.45E- 02 15 LYM20 11711. 2 H 17.1 26 1.79E- 03 38 LYM9 11633. 7 C 2.71 3 3.07E- 02 13.9 LYM53 11841. 1 H 15.6 41 2.39E- 03 26 LYM35 11812. 3 C 2.68 1 6.94E- 02 12.6 LYM67 11782. 6 H 16.7 73 4.00E- 03 35.1 LYM66 11953. 6 C 2.60 6 1.11E- 01 9.5 LYM82 12201. 1 H 14.9 07 1.38E- 02 20.1 LYM14 12051. 4 C 2.78 8 2.12E- 01 17.1 LYM12 11871. 3 H 14.0 33 1.64E- 02 13.1 LYM57 12012. 4 C 2.55 2.56E- 01 7.1 LYM26 11824. 3 H 15.3 54 2.22E- 02 23.7 LYM13 11771. 9 C 2.69 4 2.59E- 01 13.2 LYM23 8 12764. 8 H 15.5 39 2.58E- 02 25.2 LYM1 11603. 2 C 2.55 2.80E- 01 7.1 LYM88 12194. 2 H 13.6 39 3.29E- 02 9.9 LYM66 11954. 4 C 2.52 5 3.28E- 01 6.1 LYM99 12244. 2 H 14.0 55 4.42E- 02 13.2 LYM68 11942. 2 C 2.49 4 4.00E- 01 4.8 LYM53 11843. 2 H 13.7 52 6.09E- 02 10.8 LYM30 11912. 6 C 2.66 2 4.05E- 01 11.8 LYM12 8 12641. 5 H 19.0 1 6.58E- 02 53.2 2016213786 11 Aug 2016 211 Gene name Event I D Mea n P value % incr. vs. cont. Gene name Event I D Mea n P value % incr. vs. cont. LYM57 12012. 6 C 2.81 3 4.19E- 01 18.1 LYM99 12243. 1 H 18.3 8.16E- 02 47.4 LYM34 11902. 2 c 2.68 1 4.48E- 01 12.6 LYM26 11824. 1 H 16.7 06 8.96E- 02 34.6 LYM51 11893. 4 c 2.55 6 4.54E- 01 7.4 LYM12 8 12641. 3 H 16.7 7 9.41E- 02 35.1 LYM2 11695. 1 c 2.53 8 5.35E- 01 6.6 LYM23 9 13042. 9 H 15.3 16 1.28E- 01 23.4 LYM69 11851. 2 c 2.65 5.41E- 01 11.3 LYM26 11824. 6 H 15.6 43 1.64E- 01 26 LYM13 11771. 6 c 2.52 5 5.65E- 01 6.1 LYM28 5 12733. 9 H 18.9 28 1.66E- 01 52.5 LYM53 11844. 2 c 2.61 9 5.75E- 01 10 LYM20 11716. 5 H 13.6 67 1.68E- 01 10.1 LYM16 11623. 2 c 2.45 6 6.08E- 01 3.2 LYM24 12061. 4 H 15.8 75 1.72E- 01 27.9 LYM24 12061. 2 c 2.45 6.15E- 01 2.9 LYM30 11912. 7 H 13.1 13 1.73E- 01 5.7 LYM1 11604. 4 c 2.50 6 6.22E- 01 5.3 LYM11 6 13202. 7 H 14.5 2 1.78E- 01 17 LYM14 12051. 1 c 2.47 5 6.44E- 01 4 LYM10 3 12713. 5 H 16.2 34 1.81E- 01 30.8 LYM31 11924. 4 c 2.45 6 6.45E- 01 3.2 LYM66 11954. 4 H 16.5 04 1.98E- 01 33 LYM7 11594. 2 c 2.51 9 6.45E- 01 5.8 LYM66 11953. 6 H 13.0 82 2.10E- 01 5.4 LYM34 11903. 2 c 2.52 5 6.69E- 01 6.1 LYM12 11872. 1 H 19.1 53 2.18E- 01 54.3 LYM67 11783. 5 c 2.56 3 7.21E- 01 7.6 LYM95 12124. 4 H 14.5 08 2.21E- 01 16.9 LYM68 11942. 3 c 2.56 9 7.32E- 01 7.9 LYM66 11955. 2 H 14.1 24 2.35E- 01 13.8 LYM53 11842. 4 c 2.58 1 7.49E- 01 8.4 LYM31 11924. 4 H 14.2 78 2.42E- 01 15 LYM17 11683. 3 c 2.40 6 8.49E- 01 1.1 LYM95 12121. 2 H 17.1 35 3.06E- 01 38.1 LYM30 11913. 4 c 2.45 6 8.69E- 01 3.2 LYM69 11852. 2 H 14.5 17 3.11E- 01 17 LYM69 11852. 2 c 2.42 5 8.75E- 01 1.9 LYM14 12051. 4 H 14.2 54 3.15E- 01 14.8 LYM51 11891. 1 c 2.43 8 8.88E- 01 2.4 LYM12 11871. 1 H 16.2 36 3.18E- 01 30.8 LYM44 11884. 3 c 2.41 3 9.00E- 01 1.3 LYM43 11791. 4 H 13.3 52 3.60E- 01 7.6 LYM1 11602. 6 c 2.38 8 9.61E- 01 0.3 LYM10 3 12712. 8 H 14.0 75 4.03E- 01 13.4 LYM8 11982. 7 c 2.39 4 9.68E- 01 0.6 LYM23 9 13044. 8 H 13.8 81 4.35E- 01 11.8 LYM14 12054. 2 c 2.38 8 9.72E- 01 0.3 LYM62 12023. 2 H 13.4 79 4.46E- 01 8.6 LYM10 11741. 2 c 2.38 8 9.76E- 01 0.3 LYM23 2 13024. 6 H 13.4 9 4.54E- 01 8.7 2016213786 11 Aug 2016 212 Gene name Event I D Mea n P value % incr. vs. cont. Gene name Event I D Mea n P value % incr. vs. cont. LYM9 11632. 2 C 2.38 1 9.97E- 01 0 LYM67 11782. 4 H 14.2 03 4.80E- 01 14.4 CONTR OL _ c 2.38 1 _ 0 LYM30 11912. 6 H 13.8 85 4.95E- 01 11.9 LYM9 11632. 1 D 0.63 7.73E- 04 26.2 LYM15 6 12963. 1 H 13.6 92 5.55E- 01 10.3 LYM57 12013. 1 D 0.60 4 2.91E- 03 21.1 LYM23 2 13024. 7 H 15.4 09 5.68E- 01 24.1 LYM30 11912. 6 D 0.59 6.70E- 03 18.3 LYM43 11791. 5 H 12.7 38 5.74E- 01 2.6 LYM35 11812. 3 D 0.57 4 1.51E- 02 15.1 LYM99 12243. 2 H 13.0 41 5.75E- 01 5.1 LYM9 11633. 7 D 0.56 4 7.87E- 02 13 LYM12 8 12641. 1 H 13.4 74 6.12E- 01 8.6 LYM10 11744. 1 D 0.58 9.91E- 02 16.2 LYM12 11873. 4 H 12.8 38 6.27E- 01 3.4 LYM10 11741. 2 D 0.54 4 9.99E- 02 9.1 LYM26 11824. 5 H 14.9 28 6.29E- 01 20.3 LYM57 12012. 4 D 0.54 1 1.20E- 01 8.5 LYM10 3 12711. 8 H 12.7 5 6.58E- 01 2.7 LYM31 11924. 4 D 0.56 7 1.79E- 01 13.5 LYM24 12064. 1 H 13.6 85 6.61E- 01 10.3 LYM1 11602. 6 D 0.54 1 1.97E- 01 8.5 LYM26 11821. 2 H 13.6 51 6.78E- 01 10 LYM1 11603. 2 D 0.58 1 2.09E- 01 16.4 LYM11 6 13204. 4 H 14.2 29 7.49E- 01 14.6 LYM51 11891. 1 D 0.54 3 2.39E- 01 8.7 LYM43 11793. 2 H 13.0 44 8.21E- 01 5.1 LYM13 11771. 9 D 0.53 8 2.66E- 01 7.8 LYM14 5 12951. 9 H 12.4 89 8.72E- 01 0.6 LYM53 11842. 4 D 0.58 6 3.05E- 01 17.5 LYM30 11913. 5 H 12.8 46 8.73E- 01 3.5 LYM35 11813. 5 D 0.55 8 3.13E- 01 11.8 LYM30 11913. 4 H 12.6 58 8.85E- 01 2 LYM13 11771. 6 D 0.52 4 3.24E- 01 5 LYM62 12023. 5 H 12.4 88 8.95E- 01 0.6 LYM14 12051. 4 D 0.56 5 3.33E- 01 13.3 LYM28 5 12734. 9 H 12.5 63 9.45E- 01 1.2 LYM69 11852. 2 D 0.53 3 3.41E- 01 6.8 LYM10 3 12712. 5 H 12.4 58 9.73E- 01 0.4 LYM66 11953. 6 D 0.53 6 3.86E- 01 7.4 CONTR OL _ H 12.4 12 _ 0 LYM57 12012. 6 D 0.60 1 3.94E- 01 20.5 LYM12 11872. 1 J 0.05 1.96E- 04 59.7 LYM1 11604. 4 D 0.59 1 4.48E- 01 18.5 LYM11 6 13202. 12 J 0.04 6 3.31E- 04 47.1 LYM14 12051. 1 D 0.54 4.53E- 01 8.3 LYM20 11711. 2 J 0.04 5 6.36E- 04 44.3 LYM34 11902. 2 D 0.56 2 4.60E- 01 12.6 LYM12 8 12641. 5 J 0.04 4 7.56E- 04 40.5 LYM2 11695. 1 D 0.54 2 4.83E- 01 8.6 LYM28 5 12733. 9 J 0.04 5 1.31E- 03 43.5 2016213786 11 Aug 2016 213 Gene name Event I D Mea n P value % incr. vs. cont. Gene name Event I D Mea n P value % incr. vs. cont. LYM31 11923. 4 D 0.54 6 5.90E- 01 9.3 LYM23 8 12764. 8 J 0.04 2 4.59E- 03 34.9 LYM69 11851. 2 D 0.51 6 6.13E- 01 3.3 LYM26 11824. 1 J 0.04 2 7.07E- 03 33.7 LYM12 11872. 1 D 0.53 6.82E- 01 6.2 LYM23 9 13042. 9 J 0.04 1 8.56E- 03 31.8 LYM7 11594. 2 D 0.53 6.83E- 01 6.2 LYM10 3 12713. 5 J 0.04 2 9.55E- 03 34 LYM21 11674. 5 D 0.51 6.94E- 01 2.3 LYM99 12243. 1 J 0.03 9 1.57E- 02 26.4 LYM68 11942. 3 D 0.53 8 7.30E- 01 7.7 LYM12 11871. 1 J 0.04 1 1.61E- 02 31 LYM53 11844. 2 D 0.50 8 7.44E- 01 1.7 LYM67 11782. 6 J 0.04 1.77E- 02 28.2 LYM35 11811. 3 D 0.52 9 7.70E- 01 6.1 LYM11 6 13202. 7 J 0.04 2.12E- 02 28.6 LYM24 12061. 2 D 0.50 8 7.91E- 01 1.9 LYM24 12061. 4 J 0.04 2.32E- 02 28.1 LYM51 11893. 4 D 0.51 3 8.07E- 01 2.9 LYM26 11824. 6 J 0.03 9 2.72E- 02 25.9 LYM34 11903. 2 D 0.53 5 8.16E- 01 7.1 LYM12 8 12641. 3 J 0.03 9 3.65E- 02 25.4 LYM1 11601. 1 D 0.51 5 8.25E- 01 3.2 LYM26 11824. 3 J 0.03 9 4.30E- 02 23.4 LYM30 11913. 4 D 0.50 7 9.38E- 01 1.6 LYM66 11954. 4 J 0.03 8 4.56E- 02 22.5 LYM43 11791. 4 D 0.5 9.64E- 01 0.2 LYM10 3 12712. 8 J 0.03 8 5.16E- 02 22.9 CONTR OL _ D 0.49 9 _ 0 LYM95 12121. 2 J 0.03 9 5.69E- 02 23.8 LYM35 11811. 3 E 10 1.23E- 02 7.1 LYM24 12064. 1 J 0.03 9 6.86E- 02 23.9 LYM10 11744. 1 E 10.3 13 2.53E- 02 10.4 LYM23 2 13024. 7 J 0.04 8.05E- 02 28.4 LYM30 11912. 6 E 9.85 7 8.06E- 02 5.6 LYM23 2 13024. 6 J 0.03 8 8.34E- 02 20.4 LYM34 11902. 2 E 9.75 1.25E- 01 4.4 LYM14 12051. 4 J 0.03 7 9.99E- 02 19.7 LYM69 11851. 2 E 9.68 8 1.30E- 01 3.8 LYM12 11871. 3 J 0.03 7 1.14E- 01 18.1 LYM69 11852. 2 E 10.1 88 1.53E- 01 9.1 LYM30 11912. 6 J 0.03 7 1.23E- 01 18.6 LYM9 11632. 1 E 10.1 25 2.33E- 01 8.4 LYM23 9 13044. 8 J 0.03 7 1.34E- 01 17.6 LYM1 11604. 4 E 9.62 5 2.62E- 01 3.1 LYM31 11924. 4 J 0.03 6 1.64E- 01 15.9 LYM13 11772. 1 E 9.56 3 3.10E- 01 2.4 LYM15 6 12963. 1 J 0.03 6 1.70E- 01 15.9 LYM12 11872. 1 E 9.5 4.38E- 01 1.7 LYM23 8 12763. 7 J 0.03 6 1.78E- 01 14.5 LYM26 11824. 6 E 9.62 5 4.45E- 01 3.1 LYM53 11841. 1 J 0.03 6 1.78E- 01 14.9 2016213786 11 Aug 2016 214 Gene name Event I D Mea n P value % incr. vs. cont. Gene name Event I D Mea n P value % incr. vs. cont. LYM13 11771. 9 E 9.68 8 4.47E- 01 3.8 LYM11 6 13204. 4 J 0.03 8 1.81E- 01 22.8 LYM14 12051. 4 E 9.75 4.53E- 01 4.4 LYM20 11716. 5 J 0.03 6 1.95E- 01 14.5 LYM37 11801. 1 E 9.56 3 4.57E- 01 2.4 LYM26 11821. 2 J 0.03 6 2.34E- 01 14.6 LYM9 11633. 7 E 9.56 3 4.57E- 01 2.4 LYM26 11824. 5 J 0.03 7 2.36E- 01 17.1 LYM35 11812. 3 E 9.81 3 4.59E- 01 5.1 LYM12 8 12641. 1 J 0.03 5 3.24E- 01 11.7 LYM14 12054. 2 E 9.5 5.11E- 01 1.7 LYM31 11923. 4 J 0.03 5 3.32E- 01 10.6 LYM53 11842. 4 E 9.81 3 5.48E- 01 5.1 LYM53 11843. 2 J 0.03 4 3.70E- 01 9.8 LYM21 11674. 5 E 9.75 6.27E- 01 4.4 LYM69 11852. 2 J 0.03 4 3.93E- 01 9.1 LYM1 11601. 1 E 9.43 8 6.42E- 01 1.1 LYM67 11782. 4 J 0.03 4 4.05E- 01 9 LYM14 12051. 1 E 9.43 8 6.42E- 01 1.1 LYM10 3 12712. 5 J 0.03 4 4.13E- 01 9.1 LYM15 11611. 3 E 9.43 8 6.42E- 01 1.1 LYM30 11913. 5 J 0.03 4 4.32E- 01 9.6 LYM53 11844. 2 E 9.43 8 6.42E- 01 1.1 LYM88 12193. 1 J 0.03 4 4.41E- 01 8.1 LYM35 11811. 2 E 9.5 6.51E- 01 1.7 LYM10 3 12711. 8 J 0.03 4 4.68E- 01 7.8 LYM37 11803. 2 E 9.5 6.51E- 01 1.7 LYM99 12244. 2 J 0.03 4 4.71E- 01 7.7 LYM30 11913. 4 E 9.75 6.79E- 01 4.4 LYM95 12124. 4 J 0.03 4 4.71E- 01 7.6 LYM34 11903. 2 E 9.43 8 7.32E- 01 1.1 LYM31 11921. 3 J 0.03 3 5.04E- 01 7.3 LYM19 11751. 4 E 9.5 7.45E- 01 1.7 LYM66 11955. 2 J 0.03 3 5.27E- 01 6.6 LYM1 11602. 6 E 9.37 5 8.76E- 01 0.4 LYM30 11912. 7 J 0.03 3 5.60E- 01 6.4 LYM57 12012. 6 E 9.43 8 8.89E- 01 1.1 LYM62 12023. 2 J 0.03 3 5.61E- 01 6.2 LYM51 11891. 1 E 9.37 5 9.39E- 01 0.4 LYM20 11716. 3 J 0.03 3 5.84E- 01 6.4 CONTR OL _ E 9.33 7 _ 0 LYM30 11913. 4 J 0.03 3 6.20E- 01 5.8 LYM57 12012. 4 F 0.80 6 7.51E- 02 00 00* LYM23 8 12762. 8 J 0.03 3 6.21E- 01 5.6 LYM35 11811. 3 F 0.83 2.97E- 01 12.1 LYM23 8 12763. 5 J 0.03 3 6.27E- 01 5.3 LYM53 11842. 4 F 0.78 7 3.26E- 01 6.2 LYM15 6 12961. 9 J 0.03 3 6.33E- 01 5.1 LYM14 12051. 4 F 0.84 6 3.32E- 01 14.3 LYM57 12012. 2 J 0.03 3 6.41E- 01 5.1 LYM35 11813. 5 F 0.77 7 3.52E- 01 4.9 LYM14 5 12951. 9 J 0.03 3 6.87E- 01 4.4 2016213786 11 Aug 2016 215 Gene name Event I D Mea n P value % incr. vs. cont. Gene name Event I D Mea n P value % incr. vs. cont. LYM68 11942. 3 F 0.78 6 3.74E- 01 6.2 LYM12 11873. 4 J 0.03 2 7.45E- 01 3.6 LYM30 11912. 6 F 0.80 5 4.37E- 01 8.6 LYM20 11712. 2 J 0.03 2 7.62E- 01 3.5 LYM51 11891. 1 F 0.76 4 4.68E- 01 3.1 LYM41 11831. 5 J 0.03 2 7.96E- 01 2.8 LYM9 11632. 1 F 0.76 9 5.87E- 01 3.8 LYM10 3 12714. 6 J 0.03 2 8.74E- 01 1.9 LYM9 11633. 7 F 0.76 5.93E- 01 2.6 LYM28 5 12734. 9 J 0.03 2 8.76E- 01 1.8 LYM13 11771. 6 F 0.76 1 6.04E- 01 2.7 LYM23 9 13044. 7 J 0.03 2 9.02E- 01 1.4 LYM13 11771. 9 F 0.76 6.32E- 01 2.7 LYM82 12201. 1 J 0.03 2 9.28E- 01 0.9 LYM37 11801. 1 F 0.75 8 6.33E- 01 2.3 LYM66 11953. 6 J 0.03 1 9.36E- 01 0.8 LYM7 11594. 2 F 0.75 9 6.93E- 01 2.5 LYM23 8 12761. 6 J 0.03 1 9.94E- 01 0.1 LYM57 12012. 6 F 0.76 1 7.81E- 01 2.8 LYM24 12062. 3 J 0.03 1 9.97E- 01 0 LYM57 12013. 1 F 0.75 9 8.06E- 01 2.5 CONTR OL _ J 0.03 1 _ 0 LYM35 11811. 2 F 0.75 8.65E- 01 1.2 LYM26 11824. 3 K 0.68 6 7.37E- 03 43.8 LYM14 12051. 1 F 0.74 8 8.75E- 01 0.9 LYM69 11852. 2 K 0.65 9 2.22E- 02 38.2 LYM10 11744. 1 F 0.74 7 8.99E- 01 0.9 LYM12 8 12641. 1 K 0.64 1 3.49E- 02 34.5 LYM34 11903. 2 F 0.75 7 9.24E- 01 2.2 LYM95 12121. 2 K 0.64 1 3.71E- 02 34.4 LYM1 11604. 4 F 0.74 5 9.30E- 01 0.5 LYM24 12061. 4 K 0.63 3 4.62E- 02 32.8 CONTR OL _ F 0.74 1 _ 0 LYM14 12051. 4 K 0.62 7 5.47E- 02 31.5 LYM37 11801. 1 G 11.9 78 9.54E- 04 26.2 LYM12 8 12642. 1 K 0.63 5 5.90E- 02 33.2 LYM19 11754. 1 G 10.5 3 1.26E- 01 11 LYM12 8 12641. 5 K 0.62 3 7.60E- 02 30.6 LYM35 11813. 5 G 10.2 83 1.29E- 01 8.4 LYM11 6 13202. 12 K 0.60 3 8.80E- 02 26.5 LYM9 11633. 2 G 10.2 94 1.30E- 01 8.5 LYM23 8 12764. 8 K 0.60 8 8.89E- 02 27.5 LYM68 11942. 3 G 10.1 96 1.75E- 01 7.4 LYM30 11912. 6 K 0.60 5 9.08E- 02 26.8 LYM4 11706. 5 G 10.3 3 2.38E- 01 00 00* LYM27 7 13103. 1 K 0.60 2 9.87E- 02 26.1 LYM35 11811. 3 G 10.9 31 2.53E- 01 15.2 LYM26 11824. 1 K 0.59 5 1.15E- 01 24.7 LYM19 11752. 2 G 10.0 07 3.09E- 01 5.5 LYM28 5 12733. 9 K 0.59 7 1.19E- 01 25.2 LYM22 11761. 3 G 10.1 19 3.11E- 01 6.6 LYM43 11791. 4 K 0.59 6 1.21E- 01 25 2016213786 11 Aug 2016 216 Gene name Event I D Mea n P value % incr. vs. cont. Gene name Event I D Mea n P value % incr. vs. cont. LYM37 11801. 2 G 10.8 59 3.30E- 01 14.4 LYM62 12023. 5 K 0.59 3 1.29E- 01 24.3 LYM43 11791. 4 G 10.4 73 3.51E- 01 10.4 LYM12 11873. 4 K 0.59 2 1.35E- 01 24.2 LYM43 11791. 5 G 10.5 32 3.81E- 01 11 LYM11 6 13204. 4 K 0.60 7 1.36E- 01 27.4 LYM7 11594. 2 G 10.0 52 4.96E- 01 5.9 LYM30 11913. 4 K 0.59 3 1.53E- 01 24.3 LYM20 11716. 5 G 10.1 04 5.90E- 01 6.5 LYM12 1 13212. 6 K 0.58 4 1.56E- 01 22.4 LYM8 11983. 1 G 9.74 8 5.93E- 01 2.7 LYM28 5 12734. 7 K 0.6 1.70E- 01 25.9 LYM7 11591. 2 G 9.77 1 6.16E- 01 3 LYM53 11842. 4 K 0.58 1 1.70E- 01 21.9 LYM67 11781. 5 G 9.71 8 6.39E- 01 2.4 LYM95 12124. 4 K 0.57 4 1.84E- 01 20.4 LYM62 12023. 4 G 9.72 3 6.48E- 01 2.5 LYM20 11711. 2 K 0.58 1 1.90E- 01 21.7 LYM16 11624. 4 G 9.76 1 6.89E- 01 2.9 LYM12 8 12641. 3 K 0.56 9 2.06E- 01 19.3 LYM9 11634. 5 G 9.75 3 7.05E- 01 2.8 LYM62 12023. 2 K 0.57 7 2.14E- 01 21 LYM53 11842. 4 G 9.67 3 7.13E- 01 1.9 LYM14 5 12953. 5 K 0.57 1 2.18E- 01 19.7 LYM12 11874. 1 G 9.65 5 7.33E- 01 1.7 LYM53 11841. 2 K 0.56 8 2.21E- 01 19 LYM37 11803. 2 G 9.66 3 7.61E- 01 1.8 LYM28 5 12734. 9 K 0.57 6 2.21E- 01 20.8 LYM43 11791. 2 G 9.67 6 8.13E- 01 2 LYM23 2 13024. 4 K 0.57 8 2.36E- 01 21.2 LYM35 11811. 2 G 9.59 8 8.21E- 01 1.1 LYM10 3 12712. 5 K 0.57 1 2.39E- 01 19.7 LYM62 12023. 7 G 9.59 2 8.31E- 01 1.1 LYM23 2 13024. 6 K 0.56 6 2.45E- 01 18.6 LYM68 11943. 2 G 9.65 2 8.34E- 01 1.7 LYM53 11841. 1 K 0.56 8 2.50E- 01 19.2 LYM15 11612. 3 G 9.59 8.47E- 01 1.1 LYM99 12243. 1 K 0.57 6 2.57E- 01 20.8 LYM19 11753. 4 G 9.66 1 8.70E- 01 1.8 LYM24 12064. 1 K 0.56 8 2.60E- 01 19 LYM67 11782. 5 G 9.59 4 9.27E- 01 1.1 LYM11 0 12923. 8 K 0.55 9 2.60E- 01 17.2 LYM2 11693. 3 G 9.59 3 9.33E- 01 1.1 LYM66 11954. 4 K 0.56 5 2.60E- 01 18.4 LYM43 11793. 2 G 9.56 9 9.71E- 01 0.8 LYM10 3 12713. 5 K 0.56 5 2.61E- 01 18.6 LYM44 11882. 1 G 9.52 9 9.82E- 01 0.4 LYM12 11871. 1 K 0.57 2.69E- 01 19.5 LYM14 12051. 4 G 9.50 1 9.83E- 01 0.1 LYM99 12241. 1 K 0.55 8 2.70E- 01 17.1 LYM13 11773. 2 G 9.50 1 9.83E- 01 0.1 LYM82 12201. 1 K 0.56 2.74E- 01 17.5 2016213786 11 Aug 2016 217 Gene name Event I D Mea n P value % incr. vs. cont. Gene name Event I D Mea n P value % incr. vs. cont. LYM15 11614. 4 G 9.49 3 9.97E- 01 0 LYM31 11923. 4 K 0.56 4 2.76E- 01 18.2 CONTR OL _ G 9.49 _ 0 LYM99 12243. 2 K 0.55 9 2.99E- 01 17.2 LYM9 11632. 1 H 33.9 14 2.21E- 04 36.9 LYM14 5 12954. 8 K 0.55 4 3.06E- 01 16.1 LYM57 12013. 1 H 29.5 79 9.76E- 03 19.4 LYM66 11955. 2 K 0.55 7 3.10E- 01 16.7 LYM35 11812. 3 H 29.2 04 1.31E- 02 17.9 LYM28 4 12884. 6 K 0.55 4 3.10E- 01 16.1 LYM57 12012. 4 H 27.6 26 1.08E- 01 11.5 LYM23 2 13024. 7 K 0.55 4 3.11E- 01 16.1 LYM10 11744. 1 H 31.6 43 1.14E- 01 27.7 LYM23 9 13044. 8 K 0.55 5 3.13E- 01 16.4 LYM35 11813. 5 H 27.9 93 1.18E- 01 13 LYM43 11793. 2 K 0.56 3 3.17E- 01 18.1 LYM10 11741. 2 H 26.9 64 1.50E- 01 00 00* LYM14 12051. 1 K 0.55 3 3.22E- 01 15.9 LYM69 11852. 2 H 27.5 16 1.79E- 01 11 LYM11 6 13202. 7 K 0.55 2 3.34E- 01 15.7 LYM9 11633. 7 H 27.9 59 1.85E- 01 12.8 LYM95 12124. 5 K 0.54 8 3.45E- 01 14.9 LYM1 11602. 6 H 27.9 65 1.95E- 01 12.9 LYM12 1 13211. 8 K 0.54 6 3.49E- 01 14.4 LYM1 11603. 2 H 28.2 46 2.79E- 01 14 LYM24 12062. 3 K 0.54 7 3.50E- 01 14.8 LYM30 11912. 6 H 28.1 63 2.82E- 01 13.6 LYM67 11782. 5 K 0.54 6 3.51E- 01 14.5 LYM14 12051. 4 H 29.8 76 3.41E- 01 20.6 LYM53 11843. 2 K 0.54 5 3.52E- 01 14.3 LYM51 11891. 1 H 27.8 05 3.42E- 01 12.2 LYM11 0 12924. 5 K 0.54 8 3.55E- 01 15 LYM1 11604. 4 H 30.5 41 3.49E- 01 23.2 LYM99 12244. 2 K 0.54 9 3.59E- 01 15.1 LYM53 11842. 4 H 30.3 6 3.95E- 01 22.5 LYM12 11871. 3 K 0.54 7 3.66E- 01 14.6 LYM31 11924. 4 H 28.2 44 4.58E- 01 14 LYM99 12244. 1 K 0.54 9 3.66E- 01 15.1 LYM57 12012. 6 H 29.9 77 4.61E- 01 21 LYM27 1 12724. 7 K 0.54 9 3.69E- 01 15.1 LYM13 11771. 9 H 26.7 32 4.87E- 01 7.9 LYM26 11824. 5 K 0.55 7 3.69E- 01 16.8 LYM34 11902. 2 H 27.8 8 5.04E- 01 12.5 LYM30 11913. 5 K 0.54 4 3.88E- 01 14.1 LYM14 12051. 1 H 26.6 48 5.19E- 01 7.5 LYM67 11781. 5 K 0.54 3.88E- 01 13.3 LYM21 11674. 5 H 25.8 58 5.35E- 01 4.3 LYM23 8 12762. 8 K 0.54 4 3.90E- 01 14.1 LYM35 11811. 3 H 28.1 52 5.73E- 01 13.6 LYM62 12023. 4 K 0.54 4 3.93E- 01 14.1 LYM2 11695. 1 H 25.9 7 6.93E- 01 4.8 LYM14 12052. 5 K 0.54 7 3.97E- 01 14.8 2016213786 11 Aug 2016 218 Gene name Event I D Mea n P value % incr. vs. cont. Gene name Event I D Mea n P value % incr. vs. cont. LYM69 11851. 2 H 25.4 99 6.95E- 01 2.9 LYM31 11921. 3 K 0.54 4 4.06E- 01 14 LYM7 11594. 2 H 26.0 64 7.54E- 01 5.2 LYM26 11821. 2 K 0.54 4.06E- 01 13.3 LYM13 11771. 6 H 25.2 04 7.64E- 01 1.7 LYM43 11792. 2 K 0.54 4.06E- 01 13.3 LYM12 11872. 1 H 26.3 1 7.68E- 01 6.2 LYM62 12022. 4 K 0.54 4.18E- 01 13.3 LYM31 11923. 4 H 26.1 15 7.78E- 01 5.4 LYM27 1 12721. 8 K 0.53 6 4.26E- 01 12.3 LYM34 11903. 2 H 27.3 51 7.84E- 01 10.4 LYM56 13112. 6 K 0.53 6 4.32E- 01 12.4 LYM51 11893. 4 H 25.7 67 7.97E- 01 4 LYM14 5 12951. 9 K 0.53 5 4.47E- 01 12.2 LYM66 11953. 6 H 25.4 92 8.09E- 01 2.9 LYM11 0 12923. 5 K 0.53 4 4.49E- 01 12.1 LYM68 11942. 3 H 26.0 14 8.37E- 01 5 LYM11 0 12921. 7 K 0.53 7 4.51E- 01 12.6 LYM30 11913. 4 H 26.0 41 8.38E- 01 5.1 LYM12 11872. 1 K 0.53 6 4.52E- 01 12.3 LYM1 11601. 1 H 25.3 77 8.67E- 01 2.4 LYM20 11711. 3 K 0.53 3 4.57E- 01 11.8 LYM24 12061. 2 H 25.0 11 9.20E- 01 0.9 LYM57 12012. 2 K 0.53 4 4.71E- 01 11.9 LYM1 11602. 1 H 24.9 92 9.73E- 01 0.9 LYM88 12193. 1 K 0.52 9 4.85E- 01 11 LYM53 11844. 2 H 24.8 31 9.74E- 01 0.2 LYM66 11953. 6 K 0.53 4.94E- 01 11.1 CONTR OL _ H 24.7 8 _ 0 LYM31 11924. 4 K 0.53 5.07E- 01 11.1 LYM9 11632. 1 J 0.07 9 1.51E- 01 24.8 LYM67 11782. 4 K 0.53 2 5.13E- 01 11.5 LYM57 12013. 1 J 0.07 8 1.83E- 01 23 LYM28 5 12731. 4 K 0.52 5 5.18E- 01 10 LYM57 12012. 6 J 0.07 7 2.25E- 01 21.2 LYM23 9 13041. 1 K 0.52 3 5.35E- 01 9.7 LYM30 11912. 6 J 0.07 6 2.26E- 01 20.6 LYM24 12063. 3 K 0.52 1 5.41E- 01 9.2 LYM53 11842. 4 J 0.07 6 2.65E- 01 19.4 LYM15 6 12963. 1 K 0.52 2 5.54E- 01 9.4 LYM1 11604. 4 J 0.07 5 2.97E- 01 18.6 LYM12 11874. 1 K 0.52 1 5.55E- 01 9.2 LYM1 11603. 2 J 0.07 4 3.28E- 01 16.8 LYM27 1 12724. 9 K 0.52 2 5.59E- 01 9.5 LYM10 11744. 1 J 0.07 3 3.53E- 01 15.7 LYM10 3 12713. 7 K 0.52 5.64E- 01 9.1 LYM31 11924. 4 J 0.07 2 3.90E- 01 14.6 LYM14 12054. 2 K 0.51 8 5.72E- 01 8.6 LYM14 12051. 4 J 0.07 2 4.24E- 01 13.6 LYM57 12013. 3 K 0.51 9 5.89E- 01 8.9 LYM35 11812. 3 J 0.07 2 4.25E- 01 13.3 LYM31 11923. 1 K 0.51 5 6.17E- 01 7.9 2016213786 11 Aug 2016 219 Gene name Event I D Mea n P value % incr. vs. cont. Gene name Event I D Mea n P value % incr. vs. cont. LYM9 11633. 7 J 0.07 1 4.52E- 01 12.5 LYM23 8 12761. 6 K 0.51 8 6.24E- 01 8.5 LYM34 11902. 2 J 0.07 1 4.57E- 01 12.9 LYM23 2 13024. 5 K 0.51 5 6.30E- 01 7.9 LYM35 11813. 5 J 0.07 1 4.85E- 01 11.8 LYM56 13112. 7 K 0.51 2 6.37E- 01 7.3 LYM57 12012. 4 J 0.07 5.22E- 01 10.3 LYM26 11824. 6 K 0.51 6.47E- 01 6.9 LYM51 11891. 1 J 0.06 9 5.53E- 01 9.8 LYM10 3 12712. 8 K 0.51 1 6.48E- 01 7.2 LYM2 11695. 1 J 0.06 9 5.59E- 01 9.8 LYM41 11831. 1 K 0.50 9 6.63E- 01 6.8 LYM31 11923. 4 J 0.06 9 5.64E- 01 9.9 LYM27 7 13101. 1 K 0.50 8 6.88E- 01 6.6 LYM13 11771. 9 J 0.06 9 5.93E- 01 9 LYM56 13111. 7 K 0.50 9 6.88E- 01 6.7 LYM68 11942. 3 J 0.06 9 5.94E- 01 9.5 LYM28 4 12884. 7 K 0.50 6 6.90E- 01 6.2 LYM7 11594. 2 J 0.06 9 5.99E- 01 00 00* LYM62 12022. 1 K 0.50 4 7.05E- 01 5.7 LYM66 11953. 6 J 0.06 9 6.12E- 01 8.5 LYM30 11912. 7 K 0.50 7 7.06E- 01 6.3 LYM14 12051. 1 J 0.06 9 6.16E- 01 8.5 LYM41 11833. 1 K 0.50 1 7.36E- 01 5.1 LYM10 11741. 2 J 0.06 8 6.23E- 01 8.2 LYM10 3 12714. 6 K 0.50 2 7.61E- 01 5.3 LYM1 11602. 6 J 0.06 8 6.34E- 01 7.8 LYM51 11891. 1 K 0.5 7.77E- 01 4.8 LYM12 11872. 1 J 0.06 8 6.36E- 01 8 LYM23 9 13042. 9 K 0.49 8 7.78E- 01 4.5 LYM69 11852. 2 J 0.06 8 6.55E- 01 7.3 LYM24 12061. 2 K 0.49 8 7.80E- 01 4.5 LYM35 11811. 3 J 0.06 8 6.90E- 01 6.8 LYM11 6 13201. 8 K 0.49 5 8.03E- 01 3.9 LYM34 11903. 2 J 0.06 8 7.08E- 01 6.9 LYM66 11953. 1 K 0.49 6 8.07E- 01 3.9 LYM13 11771. 6 J 0.06 7 7.11E- 01 6.2 LYM27 1 12723. 2 K 0.49 7 8.18E- 01 4.3 LYM69 11851. 2 J 0.06 6 7.59E- 01 5.1 LYM27 7 13101. 8 K 0.49 5 8.23E- 01 3.9 LYM1 11601. 1 J 0.06 5 8.32E- 01 3.5 LYM12 5 12934. 7 K 0.49 4 8.28E- 01 3.6 LYM51 11893. 4 J 0.06 5 8.37E- 01 3.4 LYM12 1 13214. 3 K 0.49 3 8.30E- 01 3.4 LYM43 11791. 4 J 0.06 5 8.52E- 01 3.1 LYM88 12194. 2 K 0.49 2 8.37E- 01 3.2 LYM24 12061. 2 J 0.06 5 8.93E- 01 2.2 LYM20 11716. 5 K 0.49 8.59E- 01 2.8 LYM53 11844. 2 J 0.06 4 9.21E- 01 1.6 LYM57 12013. 5 K 0.48 8 8.85E- 01 2.3 LYM30 11913. 4 J 0.06 4 9.24E- 01 1.6 LYM66 11952. 2 K 0.48 8 8.89E- 01 2.4 2016213786 11 Aug 2016 220 Gene name Event I D Mea n P value % incr. vs. cont. Gene name Event I D Mea n P value % incr. vs. cont. LYM15 11612. 2 J 0.06 4 9.40E- 01 1.3 LYM15 6 12961. 9 K 0.48 7 8.92E- 01 2.1 LYM21 11674. 5 J 0.06 4 9.43E- 01 1.2 LYM67 11783. 5 K 0.48 5 9.13E- 01 1.7 CONTR OL _ J 0.06 3 _ 0 LYM23 2 13022. 1 K 0.48 5 9.18E- 01 1.8 LYM57 12012. 4 K 0.72 4 2.06E- 01 19.4 LYM67 11782. 6 K 0.48 3 9.35E- 01 1.3 LYM37 11803. 2 K 0.71 1 2.92E- 01 17.3 LYM14 5 12954. 7 K 0.48 2 9.41E- 01 1.2 LYM26 11824. 6 K 0.69 9 3.16E- 01 15.3 LYM12 5 12932. 6 K 0.48 3 9.42E- 01 1.4 LYM31 11921. 3 K 0.69 6 3.36E- 01 14.9 LYM12 5 12933. 8 K 0.48 1 9.60E- 01 0.8 LYM41 11831. 1 K 0.69 5 3.63E- 01 14.6 LYM28 5 12732. 5 K 0.48 9.74E- 01 0.6 LYM62 12023. 7 K 0.68 4 4.19E- 01 12.8 LYM15 6 12961. 7 K 0.47 8 9.91E- 01 0.2 LYM62 12023. 2 K 0.69 9 4.20E- 01 15.4 CONTR OL _ K 0.47 7 _ 0 LYM37 11801. 1 K 0.68 1 4.37E- 01 12.4 LYM12 8 12641. 5 L 2.44 9 2.11E- 04 59.2 LYM35 11811. 3 K 0.68 4.38E- 01 12.2 LYM11 6 13202. 12 L 2.37 5 4.83E- 04 54.4 LYM69 11852. 2 K 0.67 6 4.46E- 01 11.6 LYM12 11872. 1 L 2.46 5 7.52E- 04 60.2 LYM16 11622. 4 K 0.68 3 4.47E- 01 12.6 LYM28 5 12733. 9 L 2.38 9.95E- 04 54.7 LYM21 11671. 2 K 0.67 4 4.59E- 01 11.1 LYM99 12243. 1 L 2.24 6 lJSE- OS 46 LYM53 11841. 2 K 0.67 4 4.66E- 01 11.1 LYM20 11711. 2 L 2.20 3 4.00E- 03 43.2 LYM24 12062. 3 K 0.66 8 5.01E- 01 10.2 LYM26 11824. 1 L 2.17 1 5.72E- 03 41.1 LYM51 11892. 1 K 0.66 9 5.09E- 01 10.3 LYM12 8 12641. 3 L 2.15 6 5.90E- 03 40.1 LYM10 11744. 1 K 0.66 8 5.14E- 01 10.1 LYM95 12121. 2 L 2.15 5 1.11E- 02 40.1 LYM34 11902. 2 K 0.66 6 5.18E- 01 9.9 LYM67 11782. 6 L 2.10 7 1.18E- 02 36.9 LYM14 12054. 2 K 0.66 5 5.20E- 01 9.7 LYM66 11954. 4 L 2.09 1 1.19E- 02 35.9 LYM67 11782. 6 K 0.66 5.62E- 01 8.9 LYM12 11871. 1 L 2.08 8 2.29E- 02 35.7 LYM9 11632. 1 K 0.66 5.63E- 01 8.9 LYM24 12061. 4 L 2.04 4 2.38E- 02 32.9 LYM15 11611. 3 K 0.65 9 6.00E- 01 8.7 LYM23 8 12764. 8 L 2.03 5 2.46E- 02 32.3 LYM4 11706. 5 K 0.65 5 6.01E- 01 8 LYM10 3 12713. 5 L 2.06 5 2.84E- 02 34.2 LYM12 11872. 1 K 0.65 6 6.03E- 01 8.3 LYM26 11824. 3 L 2.01 2.91E- 02 30.7 2016213786 11 Aug 2016 221 Gene name Event I D Mea n P value % incr. vs. cont. Gene name Event I D Mea n P value % incr. vs. cont. LYM35 11812. 3 K 0.65 5 6.07E- 01 8 LYM26 11824. 6 L 1.98 3.86E- 02 28.7 LYM62 12022. 4 K 0.65 1 6.30E- 01 7.4 LYM23 9 13042. 9 L 1.97 7 4.34E- 02 28.5 LYM30 11912. 6 K 0.64 9 6.64E- 01 7 LYM53 11841. 1 L 1.97 1 4.77E- 02 28.1 LYM20 11716. 5 K 0.64 6 6.74E- 01 6.6 LYM88 12193. 1 L 1.93 6 5.80E- 02 25.8 LYM67 11781. 5 K 0.64 3 6.97E- 01 6 LYM11 6 13202. 7 L 1.90 7 8.77E- 02 24 LYM4 11702. 3 K 0.64 7.22E- 01 5.6 LYM23 2 13024. 7 L 1.97 1 l.OOE- 01 28.1 LYM69 11851. 2 K 0.63 9 7.23E- 01 5.4 LYM69 11852. 2 L 1.87 5 1.06E- 01 21.9 LYM68 11942. 2 K 0.64 7.29E- 01 5.6 LYM31 11923. 4 L 1.87 2 1.15E- 01 21.7 LYM35 11812. 4 K 0.64 3 7.31E- 01 6 LYM82 12201. 1 L 1.84 3 1.30E- 01 19.8 LYM7 11592. 1 K 0.64 7.32E- 01 5.6 LYM95 12124. 4 L 1.82 9 1.51E- 01 18.9 LYM30 11913. 4 K 0.64 1 7.33E- 01 5.8 LYM10 3 12712. 8 L 1.84 1 1.53E- 01 19.6 LYM30 11913. 3 K 0.63 8 7.35E- 01 5.2 LYM30 11912. 6 L 1.84 2 1.64E- 01 19.7 LYM8 11982. 6 K 0.63 8 7.37E- 01 5.2 LYM14 12051. 4 L 1.83 1.66E- 01 18.9 LYM2 11692. 3 K 0.64 1 7.40E- 01 5.8 LYM26 11824. 5 L 1.90 9 1.69E- 01 24.1 LYM4 11702. 1 K 0.63 4 7.62E- 01 4.5 LYM31 11924. 4 L 1.81 8 1.86E- 01 18.2 LYM41 11832. 2 K 0.63 1 7.80E- 01 4.1 LYM12 11871. 3 L 1.81 4 1.86E- 01 17.9 LYM9 11633. 2 K 0.63 4 7.80E- 01 4.5 LYM24 12064. 1 L 1.81 4 2.15E- 01 17.9 LYM9 11634. 5 K 0.63 8.00E- 01 3.9 LYM15 6 12963. 1 L 1.79 2 2.30E- 01 16.4 LYM9 11632. 2 K 0.63 8.04E- 01 3.9 LYM23 2 13024. 6 L 1.78 9 2.39E- 01 16.2 LYM53 11842. 4 K 0.63 1 8.07E- 01 4.1 LYM67 11782. 4 L 1.78 6 2.40E- 01 16.1 LYM68 11941. 3 K 0.62 9 8.08E- 01 3.7 LYM11 6 13204. 4 L 1.85 9 2.45E- 01 20.8 LYM13 11771. 9 K 0.62 9 8.13E- 01 3.7 LYM99 12244. 2 L 1.77 2 2.57E- 01 15.2 LYM57 12012. 2 K 0.62 6 8.34E- 01 3.3 LYM23 9 13044. 8 L 1.77 6 2.66E- 01 15.4 LYM21 11674. 1 K 0.62 4 8.48E- 01 2.9 LYM26 11821. 2 L 1.77 3 2.99E- 01 15.3 LYM34 11902. 4 K 0.62 4 8.48E- 01 2.9 LYM20 11716. 5 L 1.74 9 3.04E- 01 13.7 LYM41 11833. 1 K 0.62 4 8.52E- 01 2.9 LYM12 8 12641. 1 L 1.76 3 3.04E- 01 14.6 2016213786 11 Aug 2016 222 Gene name Event I D Mea n P value % incr. vs. cont. Gene name Event I D Mea n P value % incr. vs. cont. LYM1 11604. 4 K 0.62 8.86E- 01 2.3 LYM53 11843. 2 L 1.74 6 3.06E- 01 13.5 LYM9 11633. 7 K 0.62 8.87E- 01 2.3 LYM66 11955. 2 L 1.74 3.08E- 01 13.1 LYM17 11683. 1 K 0.61 9 8.89E- 01 2.1 LYM62 12023. 2 L 1.73 5 3.31E- 01 12.7 LYM15 11614. 4 K 0.61 8 9.03E- 01 1.9 LYM88 12194. 2 L 1.68 1 4.65E- 01 9.3 LYM20 11716. 3 K 0.61 8 9.05E- 01 1.9 LYM43 11791. 4 L 1.68 7 4.68E- 01 9.6 LYM62 12022. 2 K 0.61 6 9.13E- 01 1.7 LYM12 11873. 4 L 1.65 8 5.55E- 01 7.8 LYM4 11705. 2 K 0.61 6 9.15E- 01 1.7 LYM30 11913. 5 L 1.66 7 5.55E- 01 8.3 LYM21 11674. 5 K 0.61 5 9.26E- 01 1.5 LYM30 11912. 7 L 1.65 2 5.73E- 01 7.4 LYM26 11824. 3 K 0.61 5 9.27E- 01 1.5 LYM30 11913. 4 L 1.64 4 6.15E- 01 6.8 LYM69 11854. 2 K 0.61 5 9.30E- 01 1.5 LYM10 3 12711. 8 L 1.63 7 6.20E- 01 6.4 LYM67 11783. 4 K 0.61 1 9.57E- 01 0.8 LYM43 11793. 2 L 1.64 5 6.21E- 01 6.9 LYM37 11801. 2 K 0.61 1 9.57E- 01 0.8 LYM99 12243. 2 L 1.62 8 6.46E- 01 5.8 LYM67 11782. 5 K 0.61 9.67E- 01 0.6 LYM66 11953. 6 L 1.62 7 6.52E- 01 5.7 LYM62 12023. 4 K 0.61 9.70E- 01 0.6 LYM10 3 12712. 5 L 1.62 9 6.58E- 01 5.9 LYM7 11594. 2 K 0.61 9.70E- 01 0.6 LYM28 5 12734. 9 L 1.60 8 7.44E- 01 4.5 LYM16 11624. 4 K 0.60 9 9.77E- 01 0.4 LYM14 5 12951. 9 L 1.59 3 7.83E- 01 3.5 LYM7 11591. 5 K 0.60 9 9.79E- 01 0.4 LYM10 3 12714. 6 L 1.59 5 8.01E- 01 3.7 LYM31 11922. 3 K 0.60 8 9.89E- 01 0.2 LYM62 12023. 5 L 1.58 6 8.08E- 01 3.1 LYM8 11984. 1 K 0.60 6 1.00E +00 0 LYM23 8 12762. 8 L 1.58 7 8.13E- 01 3.1 CONTR OL _ K 0.60 6 _ 0 LYM43 11791. 5 L 1.57 6 8.47E- 01 2.4 LYM9 11632. 1 L 4.46 4 4.79E- 02 36.6 LYM15 6 12961. 9 L 1.57 8.76E- 01 2 LYM10 11744. 1 L 4.16 6 1.32E- 01 27.5 LYM57 12012. 2 L 1.55 1 9.48E- 01 0.8 LYM53 11842. 4 L 4.03 6 2.03E- 01 23.5 LYM20 11716. 3 L 1.55 1 9.50E- 01 0.8 LYM1 11604. 4 L 4.02 6 2.08E- 01 23.2 LYM24 12062. 3 L 1.54 6 9.69E- 01 0.5 LYM57 12012. 6 L 3.96 2 2.47E- 01 21.3 CONTR OL _ L 1.53 9 _ 0 LYM14 12051. 4 L 3.94 1 2.56E- 01 20.6 LYM12 8 12641. 5 M 0.30 6 5.45E- 04 53.9 2016213786 11 Aug 2016 223 Gene name Event I D Mea n P value % incr. vs. cont. Gene name Event I D Mea n P value % incr. vs. cont. LYM57 12013. 1 L 3.92 9 2.56E- 01 20.2 LYM11 6 13202. 12 M 0.29 7 1.21E- 03 49.2 LYM35 11812. 3 L 3.81 4 3.35E- 01 16.7 LYM12 11872. 1 M 0.30 8 1.61E- 03 54.8 LYM30 11912. 6 L 3.73 6 4.19E- 01 14.3 LYM28 5 12733. 9 M 0.29 8 2.23E- 03 49.5 LYM31 11924. 4 L 3.73 8 4.20E- 01 14.4 LYM99 12243. 1 M 0.28 1 4.33E- 03 41.1 LYM57 12012. 4 L 3.71 3 4.26E- 01 13.6 LYM20 11711. 2 M 0.27 5 8.94E- 03 38.4 LYM35 11811. 3 L 3.73 4.30E- 01 14.2 LYM26 11824. 1 M 0.27 1 1.25E- 02 36.4 LYM1 11603. 2 L 3.70 5 4.48E- 01 13.4 LYM12 8 12641. 3 M 0.26 9 1.31E- 02 35.4 LYM9 11633. 7 L 3.67 4 4.69E- 01 12.4 LYM95 12121. 2 M 0.26 9 2.19E- 02 35.4 LYM51 11891. 1 L 3.68 4.70E- 01 12.6 LYM67 11782. 6 M 0.26 3 2.45E- 02 32.3 LYM35 11813. 5 L 3.67 7 4.70E- 01 12.5 LYM66 11954. 4 M 0.26 1 2.53E- 02 31.3 LYM34 11902. 2 L 3.68 7 4.71E- 01 12.8 LYM12 11871. 1 M 0.26 1 4.25E- 02 31.2 LYM1 11602. 6 L 3.67 1 4.75E- 01 12.3 LYM24 12061. 4 M 0.25 6 4.64E- 02 28.4 LYM69 11852. 2 L 3.63 4 5.13E- 01 11.2 LYM23 8 12764. 8 M 0.25 4 4.83E- 02 27.8 LYM34 11903. 2 L 3.60 5 5.97E- 01 10.3 LYM10 3 12713. 5 M 0.25 8 5.18E- 02 29.7 LYM13 11771. 9 L 3.54 1 6.32E- 01 8.4 LYM26 11824. 3 M 0.25 1 5.70E- 02 26.3 LYM10 11741. 2 L 3.51 8 6.56E- 01 7.7 LYM26 11824. 6 M 0.24 8 7.39E- 02 24.4 LYM12 11872. 1 L 3.50 7 6.78E- 01 7.3 LYM23 9 13042. 9 M 0.24 7 8.11E- 02 24.2 LYM14 12051. 1 L 3.50 4 6.80E- 01 7.2 LYM53 11841. 1 M 0.24 6 8.78E- 02 23.8 LYM7 11594. 2 L 3.49 3 6.89E- 01 6.9 LYM88 12193. 1 M 0.24 2 1.07E- 01 21.6 LYM31 11923. 4 L 3.44 1 7.61E- 01 5.3 LYM11 6 13202. 7 M 0.23 8 1.51E- 01 19.8 LYM2 11695. 1 L 3.43 3 7.69E- 01 5.1 LYM23 2 13024. 7 M 0.24 6 1.54E- 01 23.8 LYM68 11942. 3 L 3.44 7.72E- 01 5.3 LYM69 11852. 2 M 0.23 4 1.83E- 01 17.8 LYM30 11913. 4 L 3.43 5 7.78E- 01 5.1 LYM31 11923. 4 M 0.23 4 1.95E- 01 17.6 LYM51 11893. 4 L 3.40 2 8.13E- 01 4.1 LYM82 12201. 1 M 0.23 2.22E- 01 15.8 LYM69 11851. 2 L 3.39 1 8.26E- 01 3.8 LYM26 11824. 5 M 0.23 9 2.44E- 01 19.9 LYM21 11674. 5 L 3.38 5 8.32E- 01 3.6 LYM10 3 12712. 8 M 0.23 2.49E- 01 15.6 2016213786 11 Aug 2016 224 Gene name Event I D Mea n P value % incr. vs. cont. Gene name Event I D Mea n P value % incr. vs. cont. LYM66 11953. 6 L 3.36 6 8.62E- 01 3 LYM95 12124. 4 M 0.22 9 2.51E- 01 14.9 LYM1 11601. 1 L 3.33 6 9.04E- 01 2.1 LYM30 11912. 6 M 0.23 2.60E- 01 15.7 LYM13 11771. 6 L 3.32 4 9.20E- 01 1.7 LYM14 12051. 4 M 0.22 9 2.67E- 01 14.9 LYM24 12061. 2 L 3.30 4 9.49E- 01 1.1 LYM31 11924. 4 M 0.22 7 2.94E- 01 14.2 LYM1 11602. 1 L 3.28 8 9.72E- 01 0.6 LYM12 11871. 3 M 0.22 7 2.96E- 01 14 LYM7 11592. 1 L 3.26 9 9.97E- 01 0.1 LYM24 12064. 1 M 0.22 7 3.27E- 01 14 CONTR OL _ L 3.26 8 _ 0 LYM11 6 13204. 4 M 0.23 2 3.38E- 01 16.8 LYM9 11632. 1 M 0.55 8 5.61E- 02 34.5 LYM15 6 12963. 1 M 0.22 4 3.54E- 01 12.6 LYM10 11744. 1 M 0.52 1 1.52E- 01 25.5 LYM23 2 13024. 6 M 0.22 4 3.65E- 01 12.4 LYM53 11842. 4 M 0.50 5 2.31E- 01 21.6 LYM67 11782. 4 M 0.22 3 3.66E- 01 12.2 LYM1 11604. 4 M 0.50 3 2.37E- 01 21.3 LYM99 12244. 2 M 0.22 2 3.92E- 01 11.3 LYM30 11912. 6 M 0.49 8 2.52E- 01 20.1 LYM23 9 13044. 8 M 0.22 2 3.98E- 01 11.6 LYM57 12012. 6 M 0.49 5 2.79E- 01 19.4 LYM26 11821. 2 M 0.22 2 4.31E- 01 11.4 LYM14 12051. 4 M 0.49 3 2.90E- 01 18.8 LYM12 8 12641. 1 M 0.22 4.42E- 01 10.8 LYM57 12013. 1 M 0.49 1 2.91E- 01 18.4 LYM20 11716. 5 M 0.21 9 4.53E- 01 9.9 LYM35 11812. 3 M 0.47 7 3.79E- 01 14.9 LYM53 11843. 2 M 0.21 8 4.57E- 01 9.7 LYM31 11924. 4 M 0.46 7 4.69E- 01 12.6 LYM66 11955. 2 M 0.21 8 4.64E- 01 9.3 LYM57 12012. 4 M 0.46 4 4.78E- 01 11.9 LYM62 12023. 2 M 0.21 7 4.90E- 01 9 LYM35 11811. 3 M 0.46 6 4.79E- 01 12.4 LYM43 11791. 4 M 0.21 1 6.50E- 01 6 LYM1 11603. 2 M 0.46 3 5.00E- 01 11.7 LYM88 12194. 2 M 0.21 6.56E- 01 5.6 LYM51 11891. 1 M 0.46 5.23E- 01 10.9 LYM30 11913. 5 M 0.20 8 7.36E- 01 4.7 LYM9 11633. 7 M 0.45 9 5.24E- 01 10.7 LYM12 11873. 4 M 0.20 7 7.49E- 01 4.2 LYM34 11902. 2 M 0.46 1 5.24E- 01 11.1 LYM30 11912. 7 M 0.20 7 7.70E- 01 3.8 LYM35 11813. 5 M 0.46 5.24E- 01 10.8 LYM43 11793. 2 M 0.20 6 8.08E- 01 3.4 LYM1 11602. 6 M 0.45 9 5.29E- 01 10.6 LYM30 11913. 4 M 0.20 5 8.09E- 01 3.3 LYM69 11852. 2 M 0.45 4 5.70E- 01 9.5 LYM10 3 12711. 8 M 0.20 5 8.25E- 01 2.8 2016213786 11 Aug 2016 225 Gene name Event I D Mea n P value % incr. vs. cont. Gene name Event I D Mea n P value % incr. vs. cont. LYM34 11903. 2 M 0.45 1 6.52E- 01 8.6 LYM23 8 12763. 7 M 0.20 4 8.41E- 01 2.5 LYM13 11771. 9 M 0.44 3 6.95E- 01 6.7 LYM99 12243. 2 M 0.20 4 8.56E- 01 2.3 LYM10 11741. 2 M 0.44 7.21E- 01 6 LYM10 3 12712. 5 M 0.20 4 8.60E- 01 2.3 LYM12 11872. 1 M 0.43 8 7.42E- 01 5.7 LYM66 11953. 6 M 0.20 3 8.63E- 01 2.2 LYM14 12051. 1 M 0.43 8 7.44E- 01 5.6 LYM28 5 12734. 9 M 0.20 1 9.42E- 01 1 LYM7 11594. 2 M 0.43 7 7.55E- 01 5.3 LYM31 11921. 3 M 0.2 9.69E- 01 0.5 LYM31 11923. 4 M 0.43 8.29E- 01 3.7 LYM10 3 12714. 6 M 0.19 9 9.90E- 01 0.2 LYM68 11942. 3 M 0.43 8.37E- 01 3.7 LYM14 5 12951. 9 M 0.19 9 9.95E- 01 0.1 LYM2 11695. 1 M 0.42 9 8.38E- 01 3.5 CONTR OL _ M 0.19 9 _ 0 LYM30 11913. 4 M 0.42 9 8.44E- 01 3.5 LYM11 6 13202. 12 N 0.25 5 2.10E- 05 39.1 LYM51 11893. 4 M 0.42 5 8.82E- 01 2.5 LYM12 11872. 1 N 0.26 3 2.76E- 04 43.6 LYM69 11851. 2 M 0.42 4 8.97E- 01 2.2 LYM12 8 12641. 5 N 0.24 1 3.00E- 04 31.6 LYM21 11674. 5 M 0.42 3 9.04E- 01 2 LYM20 11711. 2 N 0.23 4 6.41E- 04 28 LYM66 11953. 6 M 0.42 1 9.33E- 01 1.4 LYM23 8 12764. 8 N 0.23 6 7.16E- 04 29.2 LYM1 11601. 1 M 0.41 7 9.76E- 01 0.5 LYM26 11824. 1 N 0.23 4 1.33E- 03 28 LYM13 11771. 6 M 0.41 5 9.93E- 01 0.2 LYM12 8 12641. 3 N 0.23 2 lJSE- OS 26.7 CONTR OL _ M 0.41 5 _ 0 LYM10 3 12713. 5 N 0.23 1 2.00E- 03 26.5 LYM9 11632. 1 N 0.36 4 3.31E- 01 10.1 LYM24 12061. 4 N 0.22 7 3.42E- 03 24.1 LYM30 11912. 6 N 0.36 3 3.56E- 01 9.8 LYM23 2 13024. 6 N 0.22 8 3.85E- 03 24.4 LYM53 11842. 4 N 0.36 3 3.57E- 01 10.1 LYM28 5 12733. 9 N 0.22 9 4.57E- 03 25 LYM57 12012. 4 N 0.35 7 4.27E- 01 8.1 LYM26 11824. 3 N 0.22 6 4.79E- 03 23.5 LYM35 11813. 5 N 0.35 6 4.55E- 01 7.8 LYM66 11954. 4 N 0.22 4 5.52E- 03 22.5 LYM35 11811. 3 N 0.35 7 4.59E- 01 8.1 LYM23 9 13042. 9 N 0.22 6 5.90E- 03 23.3 LYM57 12013. 1 N 0.35 5 4.83E- 01 7.5 LYM30 11912. 6 N 0.22 7 6.07E- 03 24 LYM14 12051. 4 N 0.35 2 5.51E- 01 6.5 LYM12 8 12641. 1 N 0.22 5 9.15E- 03 23.1 LYM9 11633. 7 N 0.34 9 5.80E- 01 5.6 LYM11 6 13202. 7 N 0.22 1 1.09E- 02 20.9 2016213786 11 Aug 2016 226 Gene name Event I D Mea n P value % incr. vs. cont. Gene name Event I D Mea n P value % incr. vs. cont. LYM57 12012. 6 N 0.34 9 5.90E- 01 5.8 LYM31 11924. 4 N 0.22 1 1.24E- 02 21 LYM43 11791. 4 N 0.34 7 6.19E- 01 5.2 LYM12 11871. 1 N 0.22 6 1.29E- 02 23.3 LYM68 11942. 3 N 0.34 8 6.27E- 01 5.5 LYM14 12051. 4 N 0.22 1.51E- 02 20.4 LYM31 11924. 4 N 0.34 6 6.55E- 01 4.8 LYM24 12064. 1 N 0.22 6 1.54E- 02 23.5 LYM34 11902. 2 N 0.34 5 6.78E- 01 4.4 LYM10 3 12712. 8 N 0.21 9 1.66E- 02 19.4 LYM51 11891. 1 N 0.34 4 6.78E- 01 4.2 LYM53 11841. 1 N 0.21 9 1.67E- 02 19.7 LYM10 11744. 1 N 0.34 4 6.92E- 01 4.2 LYM95 12121. 2 N 0.22 1.74E- 02 20.4 LYM66 11953. 6 N 0.34 1 7.64E- 01 3.2 LYM30 11913. 5 N 0.22 4 1.83E- 02 22.5 LYM1 11604. 4 N 0.34 7.75E- 01 3.1 LYM31 11923. 4 N 0.21 7 2.07E- 02 18.9 LYM37 11801. 1 N 0.33 9 8.01E- 01 2.5 LYM23 2 13024. 7 N 0.23 5 2.12E- 02 28.2 LYM13 11771. 9 N 0.33 8 8.16E- 01 2.5 LYM99 12243. 1 N 0.22 2.16E- 02 20.1 LYM7 11594. 2 N 0.33 7 8.44E- 01 2.1 LYM23 9 13044. 8 N 0.21 7 2.68E- 02 18.4 LYM1 11603. 2 N 0.33 7 8.51E- 01 2 LYM26 11824. 6 N 0.21 7 2.69E- 02 18.4 LYM13 11771. 6 N 0.33 6 8.71E- 01 1.7 LYM11 6 13204. 4 N 0.23 3 2.78E- 02 27.6 LYM35 11812. 3 N 0.33 6 8.72E- 01 1.7 LYM12 11871. 3 N 0.21 8 3.06E- 02 18.9 LYM9 11633. 2 N 0.33 5 8.86E- 01 1.5 LYM67 11782. 6 N 0.21 5 3.30E- 02 17.4 LYM69 11852. 2 N 0.33 3 9.38E- 01 0.8 LYM53 11843. 2 N 0.21 2 4.67E- 02 15.7 LYM12 11872. 1 N 0.33 3 9.45E- 01 0.8 LYM10 3 12712. 5 N 0.21 2 5.01E- 02 16.1 LYM35 11811. 2 N 0.33 1 9.70E- 01 0.4 LYM30 11913. 4 N 0.21 3 5.21E- 02 16.1 LYM34 11903. 2 N 0.33 1 9.79E- 01 0.3 LYM88 12193. 1 N 0.21 1 5.46E- 02 15.1 CONTR OL _ N 0.33 _ 0 LYM23 8 12762. 8 N 0.21 1 5.60E- 02 15.4 LYM9 11632. 1 O 4.23 9 1.94E- 04 34.8 LYM12 11873. 4 N 0.21 1 5.78E- 02 15.1 LYM30 11912. 6 O 3.75 4 6.17E- 03 19.4 LYM26 11821. 2 N 0.21 5 6.72E- 02 17.8 LYM57 12013. 1 o 3.69 7 1.13E- 02 17.5 LYM69 11852. 2 N 0.21 6.75E- 02 14.7 LYM35 11812. 3 o 3.65 1.50E- 02 16 LYM28 5 12734. 9 N 0.21 2 7.54E- 02 16.1 LYM10 11744. 1 o 3.95 5 1.30E- 01 25.7 LYM26 11824. 5 N 0.22 2 7.68E- 02 21.1 2016213786 11 Aug 2016 227 Gene name Event I D Mea n P value % incr. vs. cont. Gene name Event I D Mea n P value % incr. vs. cont. LYM57 12012. 4 O 3.45 3 1.41E- 01 9.8 LYM15 6 12961. 9 N 0.20 8 7.99E- 02 13.9 LYM35 11813. 5 o 3.49 9 1.51E- 01 11.2 LYM43 11791. 4 N 0.20 8 8.13E- 02 13.6 LYM10 11741. 2 o 3.37 2.00E- 01 7.1 LYM99 12244. 2 N 0.20 7 8.64E- 02 13.3 LYM9 11633. 7 o 3.49 5 2.27E- 01 11.1 LYM23 8 12763. 7 N 0.20 5 1.20E- 01 12 LYM69 11852. 2 o 3.43 9 2.27E- 01 9.3 LYM15 6 12963. 1 N 0.20 8 1.24E- 01 13.5 LYM1 11602. 6 o 3.49 6 2.38E- 01 11.1 LYM82 12201. 1 N 0.20 4 1.29E- 01 11.7 LYM1 11603. 2 o 3.53 1 3.22E- 01 12.2 LYM95 12124. 4 N 0.20 4 1.34E- 01 11.7 LYM14 12051. 4 o 3.73 5 3.69E- 01 18.7 LYM20 11716. 5 N 0.20 4 1.46E- 01 11.3 LYM1 11604. 4 o 3.81 8 3.73E- 01 21.4 LYM31 11921. 3 N 0.20 3 1.70E- 01 10.9 LYM51 11891. 1 o 3.47 6 3.93E- 01 10.5 LYM14 5 12951. 9 N 0.20 2 1.80E- 01 10.4 LYM53 11842. 4 o 3.79 5 4.20E- 01 20.6 LYM30 11912. 7 N 0.20 2 1.85E- 01 10.1 LYM57 12012. 6 o 3.74 7 4.88E- 01 19.1 LYM67 11782. 4 N 0.20 3 2.23E- 01 11.2 LYM31 11924. 4 o 3.53 1 5.00E- 01 12.2 LYM20 11712. 2 N 0.20 3 2.24E- 01 10.7 LYM34 11902. 2 o 3.48 5 5.50E- 01 10.8 LYM28 5 12734. 7 N 0.2 2.27E- 01 9.4 LYM13 11771. 9 o 3.34 2 5.66E- 01 6.2 LYM10 3 12714. 6 N 0.20 4 2.42E- 01 11.7 LYM14 12051. 1 o 3.33 1 5.99E- 01 5.9 LYM20 11716. 3 N 0.2 2.43E- 01 9.3 LYM35 11811. 3 o 3.51 9 6.11E- 01 11.9 LYM62 12023. 2 N 0.2 2.46E- 01 9.3 LYM21 11674. 5 o 3.23 2 6.76E- 01 2.8 LYM66 11953. 6 N 0.19 7 3.17E- 01 7.7 LYM2 11695. 1 o 3.24 6 7.85E- 01 3.2 LYM23 8 12763. 5 N 0.19 7 3.17E- 01 7.7 LYM34 11903. 2 o 3.41 9 8.15E- 01 8.7 LYM23 2 13024. 5 N 0.19 7 3.18E- 01 7.7 LYM12 11872. 1 o 3.28 9 8.23E- 01 4.5 LYM24 12062. 3 N 0.19 7 3.20E- 01 7.7 LYM7 11594. 2 o 3.25 8 8.24E- 01 3.6 LYM23 9 13044. 7 N 0.19 7 3.34E- 01 7.9 LYM31 11923. 4 o 3.26 4 8.39E- 01 3.8 LYM57 12012. 2 N 0.19 6 3.40E- 01 7.3 LYM69 11851. 2 o 3.18 7 8.50E- 01 1.3 LYM10 3 12711. 8 N 0.19 5 4.17E- 01 6.4 LYM51 11893. 4 o 3.22 1 8.73E- 01 2.4 LYM53 11842. 4 N 0.19 4 4.55E- 01 5.8 LYM30 11913. 4 o 3.25 5 8.86E- 01 3.5 LYM88 12194. 2 N 0.19 3 4.99E- 01 5.2 2016213786 11 Aug 2016 228 Gene name Event I D Mea n P value % incr. vs. cont. Gene name Event I D Mea n P value % incr. vs. cont. LYM68 11942. 3 O 3.25 2 8.86E- 01 3.4 LYM14 5 12954. 8 N 0.19 4 5.03E- 01 6.2 LYM66 11953. 6 o 3.18 6 9.10E- 01 1.3 LYM12 1 13212. 6 N 0.19 3 5.34E- 01 5.4 LYM1 11601. 1 o 3.17 2 9.52E- 01 0.8 LYM23 2 13024. 4 N 0.19 4 5.39E- 01 6.1 LYM13 11771. 6 o 3.15 1 9.76E- 01 0.2 LYM67 11782. 5 N 0.19 5.94E- 01 4.1 CONTR OL _ o 3.14 6 _ 0 LYM43 11793. 2 N 0.19 2 5.99E- 01 4.7 LYM9 11632. 1 P 3.79 9 3.19E- 03 12.7 LYM14 5 12954. 7 N 0.19 2 6.07E- 01 4.8 LYM10 11744. 1 P 3.64 2 4.04E- 02 8 LYM27 7 13103. 1 N 0.19 6.17E- 01 3.9 LYM57 12012. 4 P 3.61 8 9.72E- 02 7.3 LYM12 1 13211. 8 N 0.19 6.20E- 01 3.8 LYM30 11912. 6 P 3.63 8 1.05E- 01 7.9 LYM53 11844. 2 N 0.18 9 6.49E- 01 3.5 LYM9 11633. 7 P 3.55 4 1.21E- 01 5.4 LYM12 8 12642. 1 N 0.19 6.64E- 01 3.8 LYM35 11813. 5 P 3.61 1 1.25E- 01 7.1 LYM20 11711. 3 N 0.18 9 6.73E- 01 3.3 LYM35 11812. 3 P 3.53 3 1.68E- 01 4.8 LYM23 8 12761. 6 N 0.19 6.91E- 01 3.7 LYM57 12013. 1 P 3.58 1 1.87E- 01 6.2 LYM66 11955. 2 N 0.18 8 7.07E- 01 2.9 LYM53 11842. 4 P 3.71 3 3.40E- 01 10.1 LYM41 11831. 5 N 0.18 8 7.21E- 01 2.7 LYM14 12051. 4 P 3.67 3.72E- 01 8.9 LYM23 9 13041. 7 N 0.18 8 7.27E- 01 2.8 LYM1 11603. 2 P 3.50 8 4.36E- 01 4.1 LYM14 5 12952. 9 N 0.18 9 7.54E- 01 3.5 LYM35 11811. 3 P 3.64 1 4.94E- 01 8 LYM41 11834. 2 N 0.18 8 7.59E- 01 2.7 LYM51 11891. 1 P 3.47 5.07E- 01 2.9 LYM27 7 13101. 1 N 0.18 6 8.04E- 01 1.9 LYM13 11771. 9 P 3.46 9 5.23E- 01 2.9 LYM24 12063. 3 N 0.18 6 8.26E- 01 1.8 LYM57 12012. 6 P 3.6 5.25E- 01 6.8 LYM99 12243. 2 N 0.18 5 8.58E- 01 1.4 LYM1 11604. 4 P 3.57 5.61E- 01 5.9 LYM23 9 13041. 1 N 0.18 6 8.59E- 01 1.6 LYM31 11924. 4 P 3.50 5 5.77E- 01 4 LYM43 11791. 5 N 0.18 5 8.70E- 01 1.2 LYM34 11902. 2 P 3.48 4 6.13E- 01 3.3 LYM15 6 12961. 7 N 0.18 5 9.12E- 01 0.9 LYM37 11801. 1 P 3.43 6.41E- 01 1.7 LYM31 11923. 1 N 0.18 5 9.12E- 01 0.9 LYM1 11602. 6 P 3.47 2 6.46E- 01 3 LYM62 12023. 5 N 0.18 4 9.24E- 01 0.7 LYM13 11771. 6 P 3.42 6.49E- 01 1.4 LYM15 6 12963. 4 N 0.18 5 9.26E- 01 1 2016213786 11 Aug 2016 229 Gene name Event I D Mea n P value % incr. vs. cont. Gene name Event I D Mea n P value % incr. vs. cont. LYM7 11594. 2 P 3.45 4 7.12E- 01 2.4 LYM11 6 13201. 8 N 0.18 4 9.37E- 01 0.6 LYM68 11942. 3 P 3.49 6 7.55E- 01 3.7 LYM41 11832. 2 N 0.18 4 9.65E- 01 0.4 LYM14 12051. 1 P 3.42 2 7.70E- 01 1.5 LYM11 0 12924. 5 N 0.18 3 9.85E- 01 0.2 LYM12 11872. 1 P 3.44 7 8.61E- 01 2.2 CONTR OL _ N 0.18 3 _ 0 LYM43 11791. 4 P 3.38 8 8.73E- 01 0.5 LYM11 6 13202. 12 O 2.28 9 9.00E- 06 42.6 LYM34 11903. 2 P 3.43 1 9.24E- 01 1.8 LYM88 12193. 1 O 1.96 6.36E- 04 22.1 LYM35 11811. 2 P 3.39 9.29E- 01 0.5 LYM20 11711. 2 o 2.14 1 2.08E- 03 33.4 LYM69 11852. 2 P 3.38 1 9.42E- 01 0.3 LYM53 11841. 1 o 1.95 5 4.31E- 03 21.8 LYM30 11913. 4 P 3.38 7 9.73E- 01 0.4 LYM67 11782. 6 o 2.09 7 4.70E- 03 30.6 CONTR OL _ P 3.37 2 _ 0 LYM31 11923. 4 o 1.85 5 4.75E- 03 15.6 LYM12 8 12641. 3 A 93.3 31 6.75E- 03 3.8 LYM82 12201. 1 o 1.86 3 2.54E- 02 16.1 LYM90 12393. 2 A 93.3 21 6.94E- 03 3.8 LYM26 11824. 3 o 1.91 9 3.12E- 02 19.6 LYM86 12183. 1 A 93.0 89 9.82E- 03 3.5 LYM23 8 12764. 8 o 1.94 2 3.40E- 02 21 LYM89 12211. 4 A 92.8 45 1.42E- 02 3.2 LYM12 11871. 3 o 1.75 4 6.30E- 02 9.3 LYM14 9 12343. 1 A 92.9 42 1.62E- 02 3.4 LYM12 8 12641. 5 o 2.37 6 6.82E- 02 48.1 LYM15 7 13341. 7 A 94.8 77 1.64E- 02 5.5 LYM99 12243. 1 o 2.28 7 8.62E- 02 42.5 LYM17 8 12163. 4 A 92.9 18 1.64E- 02 3.3 LYM26 11824. 1 o 2.08 8 9.91E- 02 30.1 LYM90 12393. 1 A 92.5 55 2.23E- 02 2.9 LYM12 8 12641. 3 o 2.09 6 1.04E- 01 30.6 LYM12 8 12642. 3 A 92.5 17 2.39E- 02 2.9 LYM99 12244. 2 o 1.75 7 1.07E- 01 9.5 LYM99 12243. 2 A 92.5 43 2.43E- 02 2.9 LYM88 12194. 2 o 1.70 5 1.51E- 01 6.2 LYM20 6 12601. 3 A 93.4 51 2.44E- 02 3.9 LYM23 9 13042. 9 o 1.91 5 1.56E- 01 19.3 LYM12 9 12573. 5 A 92.5 22 2.60E- 02 2.9 LYM53 11843. 2 o 1.71 9 1.75E- 01 7.1 LYM10 7 12631. 4 A 92.8 99 2.65E- 02 3.3 LYM28 5 12733. 9 o 2.36 6 1.77E- 01 47.4 LYM86 12182. 3 A 93.0 33 2.93E- 02 3.5 LYM26 11824. 6 o 1.95 5 1.91E- 01 21.8 LYM12 8 12641. 1 A 92.8 97 2.99E- 02 3.3 LYM24 12061. 4 o 1.98 4 1.96E- 01 23.6 LYM17 8 12163. 3 A 92.5 04 3.08E- 02 2.9 LYM10 3 12713. 5 o 2.02 9 2.03E- 01 26.4 2016213786 11 Aug 2016 230 Gene name Event I D Mea n P value % incr. vs. cont. Gene name Event I D Mea n P value % incr. vs. cont. LYM14 9 12344. 2 A 92.3 23 3.24E- 02 2.7 LYM66 11954. 4 O 2.06 3 2.20E- 01 28.5 LYM73 12623. 2 A 92.7 62 3.28E- 02 3.2 LYM12 11872. 1 o 2.39 4 2.31E- 01 49.2 LYM6 11735. 1 A 92.3 26 3.43E- 02 2.7 LYM11 6 13202. 7 o 1.81 5 2.36E- 01 13.1 LYM86 12181. 3 A 93.2 42 4.14E- 02 3.7 LYM95 12124. 4 o 1.81 4 2.85E- 01 13 LYM25 0 12613. 2 A 92.2 15 4.16E- 02 2.5 LYM31 11924. 4 o 1.78 5 3.22E- 01 11.2 LYM25 0 12613. 4 A 92.1 65 4.20E- 02 2.5 LYM20 11716. 5 o 1.70 8 3.22E- 01 6.4 LYM89 12214. 2 A 92.3 55 4.43E- 02 2.7 LYM66 11955. 2 o 1.76 5 3.26E- 01 10 LYM90 12395. 3 A 92.9 38 4.47E- 02 3.4 LYM95 12121. 2 o 2.14 2 3.32E- 01 33.5 LYM86 12183. 3 A 92.9 37 4.54E- 02 3.4 LYM12 11871. 1 o 2.03 3.52E- 01 26.5 LYM15 7 13341. 4 A 92.3 5 4.58E- 02 2.7 LYM69 11852. 2 o 1.81 5 3.82E- 01 13.1 LYM12 9 12573. 3 A 92.8 4 4.79E- 02 3.2 LYM14 12051. 4 o 1.78 2 4.01E- 01 11 LYM6 11734. 3 A 92.2 88 5.09E- 02 2.6 LYM10 3 12712. 8 o 1.75 9 5.04E- 01 9.6 LYM25 6 13322. 3 A 92.6 41 6.65E- 02 3 LYM23 9 13044. 8 o 1.73 5 5.52E- 01 8.1 LYM15 7 13342. 4 A 94.1 06 7.45E- 02 4.7 LYM67 11782. 4 o 1.77 5 5.69E- 01 10.6 LYM88 12191. 2 A 91.9 53 7.61E- 02 2.3 LYM43 11791. 4 o 1.66 9 5.91E- 01 4 LYM99 12244. 1 A 93.5 09 7.70E- 02 4 LYM30 11912. 7 o 1.63 9 5.96E- 01 2.1 LYM17 8 12164. 3 A 91.8 16 8.24E- 02 2.1 LYM30 11912. 6 o 1.73 6 6.07E- 01 8.1 LYM25 0 12614. 1 A 91.7 29 8.76E- 02 2 LYM23 2 13024. 7 o 1.92 6 6.15E- 01 20 LYM90 12395. 1 A 93.1 65 8.97E- 02 3.6 LYM62 12023. 2 o 1.68 5 6.23E- 01 5 LYM91 13283. 4 A 91.6 31 l.OOE- 01 1.9 LYM23 2 13024. 6 o 1.68 6 6.28E- 01 5.1 LYM17 8 12161. 2 A 92.2 39 1.02E- 01 2.6 LYM66 11953. 6 o 1.63 5 6.53E- 01 1.9 LYM12 9 12571. 3 A 91.6 67 1.10E-01 1.9 LYM15 6 12963. 1 o 1.71 1 6.79E- 01 6.6 LYM25 6 13323. 3 A 93.1 78 1.29E- 01 3.6 LYM26 11824. 5 o 1.86 6 6.82E- 01 16.3 LYM10 7 12633. 4 A 91.4 72 1.31E- 01 1.7 LYM12 8 12641. 1 o 1.68 4 7.51E- 01 4.9 LYM91 13283. 1 A 93.9 48 1.50E- 01 4.5 LYM24 12064. 1 o 1.71 1 7.64E- 01 6.6 LYM88 12193. 1 A 91.3 77 1.54E- 01 1.6 LYM26 11821. 2 o 1.70 6 7.79E- 01 6.3 2016213786 11 Aug 2016 231 Gene name Event I D Mea n P value % incr. vs. cont. Gene name Event I D Mea n P value % incr. vs. cont. LYM15 7 13341. 1 A 93.6 47 1.57E- 01 4.1 LYM11 6 13204. 4 O 1.77 9 8.04E- 01 10.8 LYM90 12392. 1 A 92.7 86 1.71E- 01 3.2 LYM99 12243. 2 o 1.63 8.51E- 01 1.6 LYM14 7 12583. 3 A 91.8 46 1.98E- 01 2.1 LYM43 11793. 2 o 1.63 9.41E- 01 1.6 LYM6 11735. 2 A 92.3 19 2.06E- 01 2.7 LYM30 11913. 5 o 1.60 6 9.98E- 01 0.1 LYM10 7 12631. 2 A 92.3 49 2.08E- 01 2.7 CONTR OL _ o 1.60 5 _ 0 LYM25 0 12614. 2 A 91.1 84 2.30E- 01 1.4 LYM20 11711. 2 P 2.43 8 2.52E- 04 17.1 LYM28 3 13304. 4 A 91.8 62 2.32E- 01 2.2 LYM23 8 12764. 8 P 2.35 7 1.15E- 03 13.2 LYM14 7 12584. 4 A 91.1 39 2.56E- 01 1.4 LYM11 6 13202. 12 P 2.55 2 3.04E- 03 22.6 LYM99 12243. 1 A 91.0 86 2.57E- 01 1.3 LYM53 11841. 1 P 2.33 8 3.08E- 03 12.3 LYM88 12192. 1 A 91.5 79 2.62E- 01 1.8 LYM82 12201. 1 P 2.29 4 5.04E- 03 10.2 LYM28 3 13304. 5 A 91.3 37 2.62E- 01 1.6 LYM31 11923. 4 P 2.28 4 6.11E- 03 9.7 LYM73 12623. 1 A 92.4 2 2.83E- 01 2.8 LYM88 12193. 1 P 2.39 3 7.93E- 03 14.9 LYM14 7 12581. 4 A 91.9 97 2.92E- 01 2.3 LYM67 11782. 6 P 2.39 3 1.64E- 02 14.9 LYM89 12214. 3 A 91.7 34 2.94E- 01 2 LYM12 8 12641. 5 P 2.57 9 3.82E- 02 23.9 LYM28 3 13302. 2 A 90.9 34 2.99E- 01 1.1 LYM99 12244. 2 P 2.24 3 4.31E- 02 7.7 LYM25 6 13321. 2 A 92.2 48 3.12E- 01 2.6 LYM12 11871. 3 P 2.21 4.39E- 02 6.1 LYM15 9 13354. 6 A 91.4 58 3.15E- 01 1.7 LYM28 5 12733. 9 P 2.53 8 4.87E- 02 21.9 LYM12 9 12572. 2 A 91.7 27 3.32E- 01 2 LYM26 11824. 3 P 2.31 5.40E- 02 10.9 LYM17 8 12164. 2 A 92.0 77 3.32E- 01 2.4 LYM24 12061. 4 P 2.34 4 5.96E- 02 12.5 LYM88 12191. 1 A 93.3 57 3.33E- 01 3.8 LYM12 8 12641. 3 P 2.41 2 6.15E- 02 15.8 LYM25 0 12611. 3 A 91.2 45 3.42E- 01 1.5 LYM53 11843. 2 P 2.23 6.53E- 02 7.1 LYM28 3 13302. 1 A 90.8 34 3.50E- 01 1 LYM66 11954. 4 P 2.44 3 6.54E- 02 17.3 LYM91 13284. 3 A 90.9 61 3.56E- 01 1.2 LYM43 11791. 4 P 2.21 1 6.54E- 02 6.2 LYM14 7 12584. 5 A 93.9 96 4.12E- 01 4.5 LYM99 12243. 1 P 2.58 2 9.80E- 02 24 LYM15 9 13352. 4 A 91.0 1 4.60E- 01 1.2 LYM31 11924. 4 P 2.26 9 1.13E- 01 9 LYM28 3 13303. 2 A 91.4 06 4.71E- 01 1.6 LYM10 3 12713. 5 P 2.42 1 1.17E- 01 16.3 2016213786 11 Aug 2016 232 Gene name Event I D Mea n P value % incr. vs. cont. Gene name Event I D Mea n P value % incr. vs. cont. LYM10 7 12632. 1 A 91.6 45 4.88E- 01 1.9 LYM88 12194. 2 P 2.18 5 1.24E- 01 4.9 LYM12 9 12572. 4 A 90.8 78 5.03E- 01 1.1 LYM26 11824. 6 P 2.33 4 1.30E- 01 12.1 LYM89 12214. 4 A 93.1 57 5.04E- 01 3.6 LYM66 11955. 2 P 2.2 1.41E- 01 5.6 LYM12 8 12642. 2 A 91.5 58 5.33E- 01 1.8 LYM12 11872. 1 P 2.73 9 1.65E- 01 31.5 LYM25 6 13321. 3 A 91.5 38 5.33E- 01 1.8 LYM11 6 13202. 7 P 2.16 3 1.71E- 01 3.9 LYM20 6 12603. 3 A 91.1 5 5.58E- 01 1.4 LYM95 12121. 2 P 2.45 6 1.79E- 01 17.9 LYM23 6 12592. 3 A 91.4 39 5.75E- 01 1.7 LYM26 11824. 1 P 2.38 9 2.02E- 01 14.7 LYM23 6 12594. 3 A 91.3 77 6.02E- 01 1.6 LYM12 11873. 4 P 2.15 3 2.17E- 01 3.4 LYM23 6 12592. 4 A 90.9 99 6.25E- 01 1.2 LYM23 9 13044. 8 P 2.22 3 2.38E- 01 6.7 LYM14 7 12583. 1 A 90.9 12 6.62E- 01 1.1 LYM66 11953. 6 P 2.16 9 2.58E- 01 4.2 LYM14 9 12341. 1 A 91.3 27 6.71E- 01 1.6 LYM23 9 13042. 9 P 2.33 2.67E- 01 11.9 LYM73 12622. 2 A 91.9 11 6.73E- 01 2.2 LYM23 2 13024. 6 P 2.22 1 2.68E- 01 6.6 LYM20 6 12601. 2 A 90.4 59 7.06E- 01 0.6 LYM12 11871. 1 P 2.37 8 3.29E- 01 14.2 LYM20 6 12603. 1 A 90.2 7 7.13E- 01 0.4 LYM95 12124. 4 P 2.24 5 3.30E- 01 7.8 LYM6 11733. 2 A 90.2 49 7.32E- 01 0.4 LYM14 12051. 4 P 2.23 4 3.46E- 01 7.3 LYM25 6 13324. 2 A 90.1 78 7.88E- 01 0.3 LYM30 11912. 7 P 2.13 4 3.65E- 01 2.5 LYM14 9 12341. 3 A 90.2 21 7.91E- 01 0.3 LYM62 12023. 2 P 2.20 2 3.71E- 01 5.7 LYM91 13284. 4 A 90.4 29 8.53E- 01 0.6 LYM10 3 12712. 8 P 2.20 1 3.96E- 01 5.7 LYM6 11736. 1 A 90.2 97 9.04E- 01 0.4 LYM20 11716. 5 P 2.15 5 4.05E- 01 3.5 LYM23 6 12593. 4 A 90.0 2 9.77E- 01 0.1 LYM69 11852. 2 P 2.18 8 4.52E- 01 5.1 LYM89 12211. 2 A 89.9 55 9.84E- 01 0 LYM30 11912. 6 P 2.20 2 5.00E- 01 5.7 CONTR OL _ A 89.9 23 _ 0 LYM14 5 12951. 9 P 2.11 7 5.23E- 01 1.7 LYM99 12243. 1 B 0.44 4 1.98E- 03 23 LYM12 8 12641. 1 P 2.19 5.43E- 01 5.2 LYM17 8 12163. 3 B 0.40 8 2.91E- 02 13.1 LYM67 11782. 4 P 2.22 1 5.46E- 01 6.7 LYM28 3 13302. 1 B 0.49 1 3.45E- 02 36 LYM23 2 13024. 7 P 2.36 6 5.92E- 01 13.6 LYM15 9 13354. 6 B 0.40 6 1.13E- 01 12.6 LYM30 11913. 5 P 2.21 6.02E- 01 6.1 2016213786 11 Aug 2016 233 Gene name Event I D Mea n P value % incr. vs. cont. Gene name Event I D Mea n P value % incr. vs. cont. LYM12 9 12573. 5 B 0.40 9 1.16E- 01 13.3 LYM26 11824. 5 P 2.26 8 6.14E- 01 8.9 LYM25 0 12613. 4 B 0.40 3 1.57E- 01 11.6 LYM11 6 13204. 4 P 2.29 2 6.62E- 01 10.1 LYM17 8 12164. 2 B 0.39 9 2.93E- 01 10.5 LYM15 6 12961. 9 P 2.10 6 6.63E- 01 1.1 LYM23 6 12594. 3 B 0.39 1 2.93E- 01 8.4 LYM28 5 12734. 9 P 2.18 9 6.81E- 01 5.1 LYM89 12214. 4 B 0.37 9 3.31E- 01 5 LYM24 12064. 1 P 2.18 2 6.92E- 01 4.8 LYM6 11736. 1 B 0.39 5 3.53E- 01 9.5 LYM15 6 12963. 1 P 2.13 8 7.88E- 01 2.7 LYM91 13284. 3 B 0.48 6 3.66E- 01 34.6 LYM30 11913. 4 P 2.11 9 8.02E- 01 1.8 LYM88 12193. 1 B 0.37 8 3.74E- 01 4.6 LYM26 11821. 2 P 2.13 9 8.11E- 01 2.7 LYM28 3 13302. 2 B 0.38 2 3.95E- 01 5.8 LYM43 11793. 2 P 2.11 9 8.47E- 01 1.8 LYM20 6 12601. 2 B 0.44 7 4.11E- 01 23.9 LYM43 11791. 5 P 2.09 6 8.52E- 01 0.6 LYM91 13284. 5 B 0.38 9 4.14E- 01 7.9 LYM10 3 12712. 5 P 2.08 5 9.78E- 01 0.1 LYM23 6 12592. 3 B 0.40 3 4.39E- 01 11.7 CONTR OL _ P 2.08 2 _ 0 LYM28 3 13304. 4 B 0.49 1 4.67E- 01 36 LYM28 9 12492. 2 A 92.9 47 1.86E- 01 1.4 LYM20 6 12603. 1 B 0.39 4.67E- 01 8.1 LYM25 5 13082. 5 A 92.8 25 2.17E- 01 1.3 LYM17 5 12651. 2 B 0.44 2 4.72E- 01 22.5 LYM17 3 12981. 6 A 93.6 46 2.22E- 01 2.2 LYM73 12623. 2 B 0.42 5 4.91E- 01 17.8 LYM10 6 12144. 4 A 92.7 05 3.20E- 01 1.2 LYM25 0 12611. 3 B 0.42 9 4.98E- 01 19 LYM21 2 13032. 8 A 92.5 13 3.49E- 01 1 LYM20 6 12603. 3 B 0.39 4.98E- 01 8.1 LYM10 2 12222. 1 A 92.5 3 3.64E- 01 1 LYM15 9 13352. 4 B 0.39 6 5.08E- 01 9.7 LYM61 13171. 8 A 96.6 67 3.77E- 01 5.5 LYM15 7 13342. 4 B 0.37 4 5.11E- 01 3.6 LYM22 0 12851. 12 A 92.9 9 4.10E- 01 1.5 LYM15 9 13354. 5 B 0.41 2 5.21E- 01 14.3 LYM11 1 12254. 3 A 92.6 06 4.40E- 01 1.1 LYM99 12243. 2 B 0.45 1 5.34E- 01 25.1 LYM28 7 12771. 6 A 93.3 04 4.59E- 01 1.8 LYM89 12211. 2 B 0.45 4 5.40E- 01 25.9 LYM21 2 13031. 5 A 93.6 14 4.80E- 01 2.2 LYM17 8 12163. 4 B 0.38 8 5.58E- 01 7.4 LYM10 6 12142. 2 A 92.2 75 4.86E- 01 0.7 LYM12 9 12573. 3 B 0.39 3 5.67E- 01 9 LYM13 8 12562. 2 A 92.3 21 4.89E- 01 0.8 LYM17 8 12164. 3 B 0.44 8 5.70E- 01 24.2 LYM11 9 12461. 1 A 92.3 76 4.93E- 01 0.8 2016213786 11 Aug 2016 234 Gene name Event I D Mea n P value % incr. vs. cont. Gene name Event I D Mea n P value % incr. vs. cont. LYM10 7 12631. 4 B 0.43 6 5.95E- 01 20.9 LYM28 8 12743. 8 A 92.2 88 5.05E- 01 0.7 LYM25 0 12613. 2 B 0.38 1 5.96E- 01 5.7 LYM27 0 12871. 7 A 92.6 01 5.14E- 01 1.1 LYM17 8 12161. 2 B 0.39 6 5.98E- 01 9.7 LYM18 3 12993. 7 A 92.2 09 5.32E- 01 0.6 LYM10 7 12633. 4 B 0.39 9 6.05E- 01 10.7 LYM13 8 12562. 1 A 92.2 98 5.80E- 01 0.7 LYM14 9 12341. 1 B 0.43 8 6.07E- 01 21.4 LYM21 2 13031. 6 A 92.7 57 5.96E- 01 1.2 LYM14 9 12344. 2 B 0.44 6 7.09E- 01 23.7 LYM22 0 12852. 2 A 92.2 25 6.15E- 01 0.7 LYM14 7 12583. 3 B 0.38 9 7.15E- 01 7.9 LYM44 11885. 4 A 92.0 76 6.37E- 01 0.5 LYM12 9 12572. 4 B 0.37 9 7.22E- 01 5.2 LYM11 1 12251. 1 A 92.2 35 6.39E- 01 0.7 LYM88 12191. 2 B 0.36 8 7.24E- 01 1.9 LYM18 3 12993. 5 A 92.2 76 6.42E- 01 0.7 LYM23 6 12591. 1 B 0.37 7.41E- 01 2.6 LYM28 9 12491. 1 A 92.3 18 6.45E- 01 0.8 LYM15 9 13354. 8 B 0.4 7.62E- 01 10.9 LYM24 2 13053. 7 A 92.3 83 6.48E- 01 0.8 LYM14 7 12583. 1 B 0.36 6 7.74E- 01 1.5 LYM20 1 12833. 9 A 92.1 11 6.51E- 01 0.5 LYM17 5 12654. 4 B 0.37 6 7.81E- 01 4.2 LYM20 1 12833. 7 A 92.1 64 6.53E- 01 0.6 LYM14 7 12584. 5 B 0.37 1 8.02E- 01 2.9 LYM24 2 13051. 8 A 92.2 32 6.65E- 01 0.7 LYM25 6 13324. 2 B 0.37 5 8.21E- 01 3.9 LYM20 8 13014. 7 A 92.4 84 6.76E- 01 0.9 LYM25 0 12614. 1 B 0.37 1 8.33E- 01 2.7 LYM19 8 13002. 8 A 92.0 42 6.93E- 01 0.5 LYM6 11735. 1 B 0.36 3 8.97E- 01 0.6 LYM15 3 12323. 2 A 91.9 83 7.00E- 01 0.4 LYM91 13283. 4 B 0.36 3 9.28E- 01 0.6 LYM14 2 12802. 7 A 92.0 44 7.19E- 01 0.5 LYM73 12623. 3 B 0.36 7 9.60E- 01 1.7 LYM18 3 12994. 8 A 92.0 15 7.24E- 01 0.4 CONTR OL _ B 0.36 1 _ 0 LYM14 2 12802. 9 A 91.9 61 7.32E- 01 0.4 LYM25 0 12613. 4 C 4.50 6 3.98E- 04 15.2 LYM61 13174. 5 A 92.7 81 7.51E- 01 1.3 LYM20 6 12601. 2 C 4.46 3 1.11E- 03 14.1 LYM10 7 12632. 3 A 91.9 22 7.63E- 01 0.3 LYM15 9 13354. 6 C 4.33 1 2.97E- 03 10.7 LYM29 1 12754. 9 A 91.8 75 7.86E- 01 0.3 LYM20 6 12603. 3 C 4.43 8 3.26E- 03 13.5 LYM20 1 12833. 6 A 93.2 31 7.98E- 01 1.8 LYM73 12623. 2 C 4.3 4.40E- 03 9.9 LYM44 11885. 3 A 91.8 67 8.04E- 01 0.3 LYM10 7 12633. 4 C 4.35 6 5.15E- 03 11.4 LYM13 0 12332. 1 A 92.0 65 8.21E- 01 0.5 2016213786 11 Aug 2016 235 Gene name Event I D Mea n P value % incr. vs. cont. Gene name Event I D Mea n P value % incr. vs. cont. LYM17 8 12163. 3 C 4.19 4 2.03E- 02 7.2 LYM13 7 12153. 1 A 91.9 68 8.65E- 01 0.4 LYM25 0 12613. 2 c 4.17 5 3.20E- 02 6.7 LYM11 1 12254. 4 A 91.8 77 8.89E- 01 0.3 LYM88 12191. 2 c 4.37 5 3.90E- 02 11.9 LYM61 13172. 4 A 92.0 25 8.90E- 01 0.4 LYM15 9 13352. 4 c 4.27 5 4.86E- 02 9.3 LYM10 0 12134. 1 A 91.7 57 8.94E- 01 0.1 LYM91 13284. 3 c 4.8 6.56E- 02 22.7 LYM90 12392. 1 A 91.7 9 9.06E- 01 0.2 LYM20 6 12603. 1 c 4.2 1.21E- 01 7.4 LYM13 0 12333. 1 A 91.9 1 9.11E- 01 0.3 LYM23 6 12594. 3 c 4.18 1 1.21E- 01 6.9 LYM19 7 12824. 4 A 91.7 79 9.37E- 01 0.2 LYM17 8 12161. 2 c 4.3 1.39E- 01 9.9 LYM90 12394. 2 A 91.6 91 9.53E- 01 0.1 LYM90 12395. 1 c 4.16 3 1.59E- 01 6.4 LYM29 1 12753. 6 A 91.6 69 9.65E- 01 0 LYM17 5 12651. 2 c 4.53 8 1.78E- 01 16 LYM10 5 12293. 1 A 91.6 57 9.77E- 01 0 LYM99 12243. 1 c 4.78 1 1.90E- 01 22.2 LYM20 8 13013. 6 A 91.6 63 9.84E- 01 0 LYM15 7 13342. 4 c 4.31 3 2.08E- 01 10.3 LYM90 12393. 4 A 91.6 27 9.99E- 01 0 LYM23 6 12592. 3 c 4.31 3 2.53E- 01 10.3 CONTR OL _ A 91.6 24 _ 0 LYM23 6 12591. 1 c 4.07 5 2.73E- 01 4.2 LYM15 2 12373. 2 B 0.35 7 1.21E- 03 50.4 LYM12 9 12573. 5 c 4.21 9 2.73E- 01 7.9 LYM10 2 12222. 1 B 0.38 6 1.41E- 03 62.7 LYM25 6 13321. 2 c 4.18 8 3.23E- 01 7.1 LYM17 4 12411. 2 B 0.34 4 2.44E- 03 44.8 LYM6 11735. 1 c 4.14 4 3.41E- 01 5.9 LYM11 1 12251. 1 B 0.37 9 3.24E- 03 59.8 LYM99 12241. 1 c 4.01 3 3.48E- 01 2.6 LYM10 0 12133. 3 B 0.34 9 3.88E- 03 47.2 LYM88 12193. 1 c 4.13 8 3.66E- 01 5.8 LYM10 6 12144. 4 B 0.33 4 6.10E- 03 40.6 LYM6 11736. 1 c 4.63 8 3.77E- 01 18.6 LYM10 7 12632. 3 B 0.38 6 6.60E- 03 62.7 LYM28 3 13304. 4 c 4.56 9 3.87E- 01 16.8 LYM17 4 12414. 3 B 0.32 4 7.65E- 03 36.4 LYM25 0 12611. 3 c 4.56 9 4.20E- 01 16.8 LYM10 2 12222. 2 B 0.34 5 9.57E- 03 45.4 LYM12 9 12572. 4 c 4.31 9 4.24E- 01 10.4 LYM10 7 12631. 2 B 0.31 2 1.54E- 02 31.4 LYM17 8 12163. 4 c 4.26 6 4.25E- 01 9.1 LYM10 2 12221. 2 B 0.33 6 1.60E- 02 41.4 LYM14 7 12583. 3 c 4 4.32E- 01 2.3 LYM10 5 12294. 3 B 0.31 3 1.62E- 02 31.7 LYM25 0 12614. 1 c 4.33 1 4.39E- 01 10.7 LYM14 3 12524. 5 B 0.31 2 1.76E- 02 31.4 2016213786 11 Aug 2016 236 Gene name Event I D Mea n P value % incr. vs. cont. Gene name Event I D Mea n P value % incr. vs. cont. LYM17 5 12654. 4 C 4.17 8 4.45E- 01 6.8 LYM10 0 12133. 1 B 0.32 5 1.79E- 02 36.9 LYM6 11733. 2 c 4.11 3 4.62E- 01 5.1 LYM19 8 13004. 6 B 0.31 9 2.41E- 02 34.3 LYM15 9 13354. 5 c 4.51 5 4.68E- 01 15.4 LYM13 7 12153. 1 B 0.30 5 2.82E- 02 28.5 LYM91 13283. 4 c 4.14 4 4.87E- 01 5.9 LYM10 7 12632. 1 B 0.34 6 3.57E- 02 45.6 LYM17 8 12164. 3 c 4.48 1 5.11E- 01 14.6 LYM11 1 12254. 4 B 0.40 4 3.60E- 02 70.4 LYM28 3 13302. 1 c 4.23 1 5.82E- 01 8.2 LYM10 5 12297. 2 B 0.29 7 4.45E- 02 25.1 LYM25 6 13323. 3 c 3.98 8 6.15E- 01 2 LYM13 7 12151. 1 B 0.32 3 4.83E- 02 36.1 LYM99 12243. 2 c 4.23 8 6.45E- 01 8.3 LYM14 3 12523. 4 B 0.29 3 4.91E- 02 23.2 LYM10 7 12631. 4 c 4.1 6.53E- 01 4.8 LYM11 1 12251. 3 B 0.31 9 5.49E- 02 34.6 LYM17 8 12164. 2 c 4.03 1 6.82E- 01 3.1 LYM10 6 12142. 3 B 0.33 6 5.57E- 02 41.4 LYM14 7 12584. 5 c 4.06 9 6.98E- 01 4 LYM22 0 12851. 8 B 0.30 1 5.77E- 02 26.9 LYM25 6 13324. 2 c 4.01 3 7.05E- 01 2.6 LYM10 2 12221. 1 B 0.29 9 6.79E- 02 26.1 LYM88 12192. 1 c 3.98 8 7.11E- 01 2 LYM17 4 12412. 1 B 0.38 4 7.26E- 02 61.7 LYM23 6 12592. 4 c 4.13 8 7.17E- 01 5.8 LYM13 7 12152. 1 B 0.28 6 8.50E- 02 20.3 LYM89 12211. 2 c 4.09 4 7.24E- 01 4.7 LYM13 7 12154. 5 B 0.29 1 8.50E- 02 22.4 LYM15 7 13341. 4 c 4.05 7.44E- 01 3.5 LYM14 3 12524. 7 B 0.28 9 9.00E- 02 21.7 LYM89 12214. 4 c 3.95 6 7.54E- 01 1.2 LYM13 8 12561. 3 B 0.29 3 9.03E- 02 23.2 LYM86 12181. 2 c 3.98 8 7.84E- 01 2 LYM10 2 12222. 3 B 0.40 4 9.03E- 02 70.1 LYM73 12622. 2 c 4.06 3 8.04E- 01 3.9 LYM14 2 12804. 1 B 0.28 5 9.32E- 02 20 LYM14 9 12344. 2 c 4.24 4 8.12E- 01 8.5 LYM10 5 12293. 1 B 0.28 3 1.01E- 01 19 LYM15 9 13354. 8 c 4.03 1 8.41E- 01 3.1 LYM10 7 12631. 1 B 0.32 6 1.1 OE-01 37.5 LYM86 12183. 3 c 3.94 4 8.67E- 01 0.8 LYM21 2 13031. 6 B 0.28 4 1.11E- 01 19.6 LYM25 6 13322. 3 c 3.92 5 9.00E- 01 0.4 LYM29 1 12754. 9 B 0.51 6 1.24E- 01 117.5 LYM28 3 13302. 2 c 3.92 5 9.20E- 01 0.4 LYM10 5 12297. 1 B 0.40 2 1.35E- 01 69.3 LYM6 11735. 2 c 3.93 1 9.33E- 01 0.5 LYM13 8 12562. 1 B 0.27 8 1.36E- 01 17.2 CONTR OL — c 3.91 1 — 0 LYM10 0 12131. 2 B 0.35 1.42E- 01 47.4 2016213786 11 Aug 2016 237 Gene name Event I D Mea n P value % incr. vs. cont. Gene name Event I D Mea n P value % incr. vs. cont. LYM10 7 12631. 4 D 0.28 6 2.09E- 03 30.2 LYM10 0 12131. 3 B 0.3 1.45E- 01 26.4 LYM23 6 12592. 3 D 0.28 2 3.12E- 03 28.3 LYM28 9 12491. 1 B 0.34 8 1.51E- 01 46.7 LYM14 7 12583. 3 D 0.27 8 7.97E- 03 26.3 LYM17 3 12982. 7 B 0.32 6 1.56E- 01 37.5 LYM12 9 12572. 4 D 0.27 9.42E- 03 22.7 LYM10 6 12144. 3 B 0.35 1 1.59E- 01 48 LYM6 11736. 1 D 0.26 8 1.07E- 02 22.1 LYM17 4 12414. 2 B 0.38 4 1.60E- 01 61.7 LYM17 8 12163. 4 D 0.28 3 1.31E- 02 28.9 LYM10 7 12633. 4 B 0.37 2 1.75E- 01 56.7 LYM89 12211. 4 D 0.26 9 3.53E- 02 22.3 LYM21 2 13032. 8 B 0.30 4 1.89E- 01 28.2 LYM73 12623. 2 D 0.25 4 4.68E- 02 15.5 LYM15 3 12324. 2 B 0.27 1 1.90E- 01 14.3 LYM90 12395. 3 D 0.28 5 6.11E- 02 29.5 LYM14 3 12521. 1 B 0.30 3 1.91E- 01 27.5 LYM99 12243. 2 D 0.26 3 6.21E- 02 19.6 LYM13 8 12561. 1 B 0.31 9 1.91E- 01 34.3 LYM88 12193. 1 D 0.28 8 6.59E- 02 30.9 LYM10 0 12134. 1 B 0.29 8 1.91E- 01 25.6 LYM20 6 12603. 1 D 0.27 1 6.76E- 02 23.2 LYM15 2 12371. 3 B 0.31 1 2.03E- 01 30.9 LYM25 0 12613. 2 D 0.25 1 6.95E- 02 14.5 LYM28 9 12493. 2 B 0.28 1 2.03E- 01 18.5 LYM90 12392. 1 D 0.24 9 7.55E- 02 13.5 LYM10 6 12142. 2 B 0.45 1 2.04E- 01 89.9 LYM86 12182. 3 D 0.24 7 9.53E- 02 12.5 LYM10 6 12141. 4 B 0.42 7 2.09E- 01 79.9 LYM90 12395. 1 D 0.27 8 1.03E- 01 26.4 LYM17 3 12982. 6 B 0.34 2.21E- 01 43.3 LYM14 7 12584. 4 D 0.24 4 1.25E- 01 11.2 LYM10 7 12631. 4 B 0.50 3 2.37E- 01 112.1 LYM17 8 12161. 2 D 0.26 8 1.42E- 01 22.2 LYM13 7 12151. 4 B 0.33 7 2.43E- 01 41.9 LYM23 6 12594. 3 D 0.24 5 1.49E- 01 11.3 LYM28 8 12744. 7 B 0.31 9 2.48E- 01 34.3 LYM12 8 12641. 3 D 0.24 3 1.63E- 01 10.8 LYM15 3 12324. 1 B 0.37 6 2.54E- 01 58.3 LYM17 8 12164. 3 D 0.24 2 1.63E- 01 10.3 LYM11 1 12254. 3 B 0.27 5 2.65E- 01 15.9 LYM20 6 12603. 3 D 0.34 5 1.82E- 01 57 LYM19 7 12824. 4 B 0.34 2.66E- 01 43.4 LYM15 9 13354. 6 D 0.25 7 1.95E- 01 16.9 LYM10 2 12222. 6 B 0.52 8 2.70E- 01 122.3 LYM73 12623. 1 D 0.24 7 2.14E- 01 12.5 LYM15 2 12371. 2 B 0.32 3 2.76E- 01 35.9 LYM15 9 13354. 5 D 0.24 1 2.20E- 01 9.8 LYM22 0 12851. 12 B 0.26 6 2.76E- 01 11.9 LYM12 9 12573. 3 D 0.26 7 2.33E- 01 21.4 LYM13 8 12566. 1 B 0.29 6 2.78E- 01 24.6 2016213786 11 Aug 2016 238 Gene name Event I D Mea n P value % incr. vs. cont. Gene name Event I D Mea n P value % incr. vs. cont. LYM25 0 12613. 4 D 0.32 6 2.36E- 01 48.2 LYM19 8 13002. 6 B 0.40 1 2.91E- 01 68.8 LYM10 7 12633. 4 D 0.32 1 2.54E- 01 45.9 LYM17 3 12981. 5 B 0.26 8 2.98E- 01 13 LYM88 12191. 2 D 0.28 5 2.57E- 01 29.6 LYM14 2 12802. 9 B 0.32 3 3.06E- 01 36.1 LYM17 5 12651. 2 D 0.24 1 2.65E- 01 9.5 LYM44 11884. 1 B 0.26 3 3.14E- 01 10.6 LYM6 11735. 1 D 0.29 8 2.86E- 01 35.7 LYM14 3 12521. 2 B 0.26 5 3.27E- 01 11.7 LYM25 0 12614. 1 D 0.24 2.88E- 01 9.2 LYM15 2 12372. 2 B 0.28 4 3.43E- 01 19.7 LYM15 7 13341. 4 D 0.23 5 3.14E- 01 7.1 LYM28 8 12743. 9 B 0.38 1 3.52E- 01 60.6 LYM17 8 12163. 3 D 0.27 4 3.28E- 01 24.7 LYM17 3 12981. 6 B 0.32 7 3.64E- 01 37.7 LYM99 12243. 1 D 0.29 8 3.29E- 01 35.7 LYM11 1 12252. 2 B 0.40 9 3.69E- 01 72.2 LYM88 12194. 2 D 0.24 2 3.37E- 01 10 LYM11 1 12251. 4 B 0.33 6 3.76E- 01 41.7 LYM12 9 12573. 5 D 0.28 6 3.40E- 01 30 LYM28 9 12491. 4 B 0.35 6 3.78E- 01 50.1 LYM86 12183. 3 D 0.23 5 3.42E- 01 6.9 LYM19 8 13002. 8 B 0.27 6 3.80E- 01 16.1 LYM89 12214. 2 D 0.28 3 3.49E- 01 29 LYM11 9 12463. 2 B 0.33 6 3.81E- 01 41.4 LYM20 6 12601. 2 D 0.33 2 3.68E- 01 51 LYM10 5 12294. 2 B 0.30 9 3.82E- 01 30.3 LYM12 8 12642. 3 D 0.25 4 4.14E- 01 15.4 LYM25 5 13082. 5 B 0.26 8 3.92E- 01 12.7 LYM91 13284. 3 D 0.25 7 4.24E- 01 16.8 LYM14 2 12803. 6 B 0.42 6 3.92E- 01 79.3 LYM23 6 12591. 1 D 0.27 4.45E- 01 23 LYM10 5 12295. 2 B 0.32 6 3.98E- 01 37.5 LYM91 13283. 1 D 0.23 1 4.60E- 01 5 LYM20 8 13013. 6 B 0.35 9 4.05E- 01 51.2 LYM89 12214. 3 D 0.25 6 4.88E- 01 16.3 LYM24 2 13051. 8 B 0.31 2 4.11E- 01 31.4 LYM20 6 12601. 3 D 0.23 2 5.03E- 01 5.4 LYM18 3 12991. 7 B 0.25 8 4.18E- 01 8.5 LYM86 12183. 1 D 0.24 5 5.08E- 01 11.6 LYM11 9 12461. 1 B 0.27 4.22E- 01 13.8 LYM23 6 12592. 4 D 0.26 9 5.38E- 01 22.2 LYM14 2 12801. 8 B 0.25 8 4.22E- 01 00 00* LYM17 5 12654. 4 D 0.26 2 5.39E- 01 19 LYM28 8 12743. 8 B 0.26 9 4.37E- 01 13.5 LYM90 12393. 1 D 0.25 1 5.42E- 01 14.3 LYM28 7 12773. 7 B 0.30 3 4.38E- 01 27.5 LYM25 0 12614. 2 D 0.24 3 5.44E- 01 10.5 LYM21 2 13031. 5 B 0.26 6 4.43E- 01 11.9 LYM25 0 12611. 3 D 0.26 5 5.54E- 01 20.5 LYM25 5 13082. 7 B 0.26 4 4.46E- 01 11.4 2016213786 11 Aug 2016 239 Gene name Event I D Mea n P value % incr. vs. cont. Gene name Event I D Mea n P value % incr. vs. cont. LYM28 3 13304. 4 D 0.25 1 6.17E- 01 14.1 LYM14 3 12524. 2 B 0.30 9 4.52E- 01 30.3 LYM6 11733. 2 D 0.23 5 6.79E- 01 6.8 LYM15 3 12321. 2 B 0.30 3 4.54E- 01 27.5 LYM14 7 12584. 5 D 0.22 7 6.93E- 01 3.3 LYM27 0 12871. 7 B 0.26 4 4.64E- 01 11.1 LYM15 7 13342. 4 D 0.24 9 7.01E- 01 13.2 LYM20 8 13012. 8 B 0.34 9 4.64E- 01 46.9 LYM91 13283. 4 D 0.24 8 7.12E- 01 12.8 LYM22 0 12851. 11 B 0.27 3 4.64E- 01 15 LYM12 8 12641. 1 D 0.23 6 7.33E- 01 7.6 LYM25 5 13082. 9 B 0.32 7 4.69E- 01 37.7 LYM20 6 12603. 2 D 0.22 5 7.44E- 01 2.4 LYM15 2 12373. 1 B 0.25 6 4.76E- 01 8 LYM73 12622. 2 D 0.23 4 8.40E- 01 6.4 LYM17 4 12411. 3 B 0.26 5 4.89E- 01 11.7 LYM17 5 12654. 6 D 0.22 6 8.63E- 01 2.7 LYM17 3 12981. 8 B 0.25 4 4.95E- 01 7 LYM15 9 13352. 4 D 0.22 5 8.63E- 01 2.3 LYM28 8 12741. 9 B 0.26 8 5.10E- 01 12.7 LYM14 7 12583. 1 D 0.23 5 8.75E- 01 7.2 LYM27 0 12871. 5 B 0.26 2 5.13E- 01 10.5 LYM17 8 12164. 2 D 0.22 6 8.77E- 01 3 LYM44 11885. 4 B 0.28 1 5.16E- 01 18.5 LYM88 12191. 1 D 0.22 5 9.11E- 01 2.2 LYM11 9 12462. 2 B 0.36 1 5.34E- 01 52.2 LYM89 12214. 4 D 0.22 1 9.16E- 01 0.7 LYM13 0 12332. 2 B 0.27 5 5.42E- 01 15.9 LYM14 9 12344. 2 D 0.22 7 9.29E- 01 3.5 LYM21 2 13034. 9 B 0.25 6 5.42E- 01 8 LYM14 7 12581. 4 D 0.22 3 9.55E- 01 1.6 LYM14 2 12804. 3 B 0.25 9 5.43E- 01 9.3 LYM17 5 12651. 4 D 0.22 2 9.80E- 01 1 LYM19 7 12824. 7 B 0.29 3 5.46E- 01 23.2 CONTR OL _ D 0.22 _ 0 LYM22 0 12851. 13 B 0.26 2 5.67E- 01 10.3 LYM10 7 12633. 4 E 9.18 8 1.23E- 03 8.4 LYM19 8 13002. 5 B 0.28 2 5.80E- 01 18.8 LYM20 6 12603. 3 E 9.18 8 1.23E- 03 8.4 LYM13 7 12151. 2 B 0.25 2 5.93E- 01 6.1 LYM88 12193. 1 E 9.06 3 3.77E- 03 6.9 LYM18 3 12993. 7 B 0.27 7 6.04E- 01 16.7 LYM6 11734. 3 E 9.12 5 2.59E- 02 7.7 LYM21 2 13034. 8 B 0.29 4 6.34E- 01 23.8 LYM15 7 13341. 4 E 8.81 3 4.79E- 02 4 LYM22 0 12852. 2 B 0.26 1 6.54E- 01 10.1 LYM28 3 13304. 4 E 8.81 3 4.79E- 02 4 LYM13 0 12331. 3 B 0.28 4 6.60E- 01 19.6 LYM17 8 12164. 3 E 8.87 5 9.63E- 02 4.7 LYM28 8 12744. 6 B 0.25 8 6.65E- 01 00 00* LYM90 12393. 1 E 9.06 3 1.17E- 01 6.9 LYM29 1 12753. 6 B 0.24 9 6.65E- 01 5.1 2016213786 11 Aug 2016 240 Gene name Event I D Mea n P value % incr. vs. cont. Gene name Event I D Mea n P value % incr. vs. cont. LYM90 12395. 1 E 9.12 5 1.79E- 01 7.7 LYM13 8 12564. 1 B 0.25 9 6.70E- 01 9 LYM25 0 12613. 4 E 8.68 8 1.79E- 01 2.5 LYM28 9 12492. 2 B 0.26 3 6.79E- 01 10.6 LYM99 12243. 2 E 8.68 8 1.79E- 01 2.5 LYM20 1 12833. 7 B 0.28 1 6.89E- 01 18.5 LYM10 7 12631. 4 E 8.75 2.07E- 01 3.2 LYM13 0 12334. 1 B 0.24 7 7.13E- 01 4 LYM73 12623. 2 E 8.75 2.07E- 01 3.2 LYM13 8 12562. 2 B 0.25 2 7.28E- 01 6.1 LYM90 12395. 3 E 9.18 8 3.34E- 01 8.4 LYM14 2 12802. 7 B 0.24 6 7.38E- 01 3.5 LYM14 7 12583. 3 E 8.68 8 4.46E- 01 2.5 LYM13 0 12333. 1 B 0.25 7 7.42E- 01 8.2 LYM25 0 12614. 1 E 8.68 8 4.46E- 01 2.5 LYM15 3 12323. 2 B 0.25 5 7.44E- 01 7.4 LYM12 8 12642. 3 E 8.62 5 4.56E- 01 1.8 LYM10 6 12142. 1 B 0.26 2 7.70E- 01 10.3 LYM12 9 12573. 3 E 8.62 5 4.56E- 01 1.8 LYM27 0 12872. 5 B 0.24 4 7.99E- 01 2.7 LYM88 12191. 2 E 8.62 5 4.56E- 01 1.8 LYM18 3 12994. 7 B 0.24 3 8.20E- 01 2.4 LYM89 12211. 4 E 8.62 5 4.56E- 01 1.8 LYM24 2 13053. 7 B 0.24 2 8.52E- 01 1.9 LYM99 12243. 1 E 8.62 5 4.56E- 01 1.8 LYM18 3 12994. 8 B 0.24 3 8.58E- 01 2.2 LYM20 6 12603. 1 E 8.56 3 5.62E- 01 1 LYM29 1 12751. 7 B 0.24 3 8.65E- 01 2.4 LYM6 11733. 2 E 8.56 3 5.62E- 01 1 LYM28 7 12771. 6 B 0.24 1 8.75E- 01 1.6 LYM86 12182. 3 E 8.56 3 5.62E- 01 1 LYM44 11884. 3 B 0.24 6 9.08E- 01 3.8 LYM6 11735. 1 E 8.81 3 5.79E- 01 4 LYM27 0 12872. 7 B 0.24 5 9.08E- 01 3.2 LYM23 6 12591. 1 E 8.75 5.95E- 01 3.2 LYM25 5 13081. 5 B 0.24 4 9.17E- 01 3 LYM73 12623. 1 E 8.75 5.95E- 01 3.2 LYM27 0 12871. 8 B 0.23 8 9.96E- 01 0.1 LYM17 8 12163. 3 E 8.68 8 6.19E- 01 2.5 CONTR OL _ B 0.23 7 _ 0 LYM14 7 12584. 4 E 8.56 3 7.37E- 01 1 LYM10 2 12221. 2 C 3.18 1 7.20E- 05 59.4 LYM91 13283. 1 E 8.56 3 8.30E- 01 1 LYM17 4 12411. 2 C 3.1 1.24E- 04 55.4 LYM23 6 12594. 3 E 8.62 5 8.51E- 01 1.8 LYM11 1 12254. 4 C 3.5 1.46E- 04 75.4 LYM25 0 12613. 2 E 8.5 8.55E- 01 0.3 LYM13 7 12151. 1 C 3.04 4 1.55E- 04 52.5 LYM12 8 12641. 3 E 8.5 8.98E- 01 0.3 LYM10 2 12222. 2 C 3.03 1 2.15E- 04 51.9 LYM20 6 12601. 2 E 8.5 8.98E- 01 0.3 LYM19 8 13004. 6 C 2.96 9 2.68E- 04 48.8 2016213786 11 Aug 2016 241 Gene name Event I D Mea n P value % incr. vs. cont. Gene name Event I D Mea n P value % incr. vs. cont. LYM23 6 12592. 3 E 8.5 8.98E- 01 0.3 LYM10 6 12144. 4 C 2.88 1 4.76E- 04 44.4 LYM15 9 13354. 5 E 8.52 1 9.20E- 01 0.5 LYM17 4 12414. 3 c 2.85 6 5.73E- 04 43.1 LYM12 9 12572. 4 E 8.5 9.40E- 01 0.3 LYM15 2 12373. 2 c 2.85 6 6.33E- 04 43.1 LYM17 5 12653. 3 E 8.5 9.40E- 01 0.3 LYM10 5 12297. 2 c 2.86 9 7.57E- 04 43.8 LYM17 8 12164. 2 E 8.5 9.40E- 01 0.3 LYM13 7 12152. 1 c 2.73 1 1.65E- 03 36.9 LYM99 12241. 1 E 8.5 9.40E- 01 0.3 LYM10 0 12134. 1 c 2.88 1 1.87E- 03 44.4 LYM15 7 13342. 4 E 8.5 9.59E- 01 0.3 LYM10 7 12632. 1 c 2.91 3 2.19E- 03 46 CONTR OL _ E 8.47 5 _ 0 LYM10 5 12294. 3 c 2.8 2.39E- 03 40.3 LYM20 6 12603. 3 F 0.57 9 5.70E- 05 43 LYM10 7 12631. 1 c 2.68 8 2.68E- 03 34.7 LYM23 6 12592. 3 F 0.48 7 6.32E- 03 20.3 LYM10 7 12632. 3 c 3.3 3.16E- 03 65.4 LYM73 12623. 1 F 0.44 2 1.25E- 01 9.2 LYM10 7 12631. 2 c 2.68 1 6.82E- 03 34.4 LYM12 9 12572. 4 F 0.44 2 1.62E- 01 9.1 LYM10 0 12133. 3 c 3.29 4 7.28E- 03 65.1 LYM73 12623. 2 F 0.43 8 1.80E- 01 8 LYM19 7 12824. 4 c 2.73 8 9.52E- 03 37.2 LYM15 9 13354. 6 F 0.44 3 1.85E- 01 9.4 LYM10 6 12141. 4 c 3.67 5 1.04E- 02 84.2 LYM20 6 12603. 1 F 0.45 6 1.88E- 01 12.6 LYM15 2 12373. 1 c 2.5 1.15E- 02 25.3 LYM25 0 12613. 4 F 0.53 3 2.23E- 01 31.6 LYM14 3 12523. 4 c 2.55 6 1.22E- 02 28.1 LYM14 7 12583. 3 F 0.43 4 2.25E- 01 7.1 LYM11 1 12251. 1 c 3.52 5 1.30E- 02 76.7 LYM90 12395. 3 F 0.43 2 2.54E- 01 6.6 LYM29 1 12754. 9 c 4.03 1 1.90E- 02 102 LYM90 12395. 1 F 0.45 9 2.58E- 01 13.2 LYM14 2 12804. 1 c 2.49 4 2.73E- 02 25 LYM17 8 12163. 4 F 0.48 7 2.76E- 01 20.2 LYM10 2 12221. 1 c 2.81 3 3.28E- 02 41 LYM89 12211. 4 F 0.43 3 2.87E- 01 7 LYM28 8 12744. 7 c 2.63 8 3.46E- 02 32.2 LYM25 0 12614. 1 F 0.42 9 3.05E- 01 5.8 LYM10 0 12131. 2 c 3.15 4 3.50E- 02 58 LYM10 7 12633. 4 F 0.48 7 3.08E- 01 20.2 LYM11 1 12254. 3 c 2.56 3 3.71E- 02 28.4 LYM23 6 12591. 1 F 0.48 1 3.14E- 01 18.8 LYM10 5 12297. 1 c 3.26 9 4.57E- 02 63.8 LYM88 12193. 1 F 0.49 3.39E- 01 20.9 LYM21 2 13031. 5 c 2.35 4 4.66E- 02 18 LYM23 6 12594. 3 F 0.46 3.51E- 01 13.6 LYM18 3 12991. 7 c 2.45 6 4.75E- 02 23.1 2016213786 11 Aug 2016 242 Gene name Event I D Mea n P value % incr. vs. cont. Gene name Event I D Mea n P value % incr. vs. cont. LYM99 12243. 1 F 0.49 6 3.78E- 01 22.5 LYM10 2 12222. 1 C 3.55 6 5.16E- 02 78.2 LYM6 11735. 1 F 0.48 2 4.20E- 01 19.1 LYM14 3 12524. 5 c 2.75 6 5.74E- 02 38.1 LYM17 8 12161. 2 F 0.46 5 4.22E- 01 14.9 LYM10 2 12222. 3 c 3.76 9 6.05E- 02 88.9 LYM25 0 12614. 2 F 0.45 2 4.40E- 01 11.5 LYM10 5 12293. 1 c 2.41 9 6.23E- 02 21.2 LYM15 7 13341. 4 F 0.43 5 4.48E- 01 7.4 LYM27 0 12871. 5 c 2.32 1 6.49E- 02 16.3 LYM17 5 12654. 4 F 0.47 2 4.48E- 01 16.5 LYM15 3 12324. 2 c 2.31 3 7.05E- 02 15.9 LYM12 9 12573. 5 F 0.45 7 4.50E- 01 12.9 LYM10 0 12133. 1 c 3.28 8 7.40E- 02 64.8 LYM20 6 12603. 2 F 0.42 2 4.75E- 01 4.3 LYM10 6 12142. 3 c 3.03 8 8.14E- 02 52.2 LYM12 8 12641. 1 F 0.42 4 4.85E- 01 4.7 LYM15 2 12372. 2 c 2.60 5 9.07E- 02 30.6 LYM17 8 12163. 3 F 0.44 1 4.99E- 01 8.9 LYM17 4 12414. 2 c 3.1 9.40E- 02 55.4 LYM20 6 12601. 2 F 0.5 5.39E- 01 23.5 LYM17 4 12412. 1 c 3.26 9 1.06E- 01 63.8 LYM88 12191. 2 F 0.44 6 6.11E- 01 10.2 LYM10 6 12144. 3 c 2.81 3 1.07E- 01 41 LYM15 9 13354. 5 F 0.41 6 7.19E- 01 2.8 LYM27 0 12872. 5 c 2.37 5 1.14E- 01 19 LYM12 9 12573. 3 F 0.41 8 7.51E- 01 3.1 LYM13 8 12566. 1 c 2.83 8 1.14E- 01 42.2 LYM89 12214. 3 F 0.41 2 8.15E- 01 1.7 LYM13 8 12561. 3 c 2.61 9 1.21E- 01 31.2 LYM89 12214. 2 F 0.42 2 8.16E- 01 4.1 LYM17 3 12981. 8 c 2.26 3 1.25E- 01 13.4 LYM28 3 13304. 4 F 0.42 8.23E- 01 3.8 LYM28 9 12491. 1 c 2.9 1.26E- 01 45.3 LYM23 6 12592. 4 F 0.42 5 8.29E- 01 5 LYM14 3 12521. 1 c 2.61 3 1.32E- 01 30.9 LYM25 0 12611. 3 F 0.41 6 8.42E- 01 2.7 LYM17 3 12982. 6 c 2.86 3 1.34E- 01 43.5 LYM10 7 12631. 4 F 0.40 9 9.12E- 01 0.9 LYM21 2 13032. 8 c 2.43 8 1.36E- 01 22.2 LYM90 12393. 1 F 0.41 1 9.45E- 01 1.4 LYM13 8 12562. 1 c 2.56 9 1.40E- 01 28.7 LYM15 9 13352. 4 F 0.40 7 9.49E- 01 0.4 LYM21 2 13034. 9 c 2.24 4 1.40E- 01 12.5 LYM91 13284. 3 F 0.41 9.52E- 01 1.2 LYM10 6 12142. 2 c 3.73 1 1.41E- 01 87 LYM91 13283. 4 F 0.41 1 9.54E- 01 1.4 LYM15 3 12324. 1 c 2.83 1 1.48E- 01 41.9 CONTR OL _ F 0.40 5 _ 0 LYM10 0 12131. 3 c 2.85 6 1.54E- 01 43.1 LYM6 11734. 3 G 9.53 2.63E- 01 9.9 LYM10 7 12631. 4 c 4.22 1 1.57E- 01 111.6 2016213786 11 Aug 2016 243 Gene name Event I D Mea n P value % incr. vs. cont. Gene name Event I D Mea n P value % incr. vs. cont. LYM20 6 12603. 3 G 9.77 2 3.62E- 01 12.7 LYM28 9 12493. 2 C 2.23 1 1.58E- 01 11.8 LYM23 6 12591. 1 G 9.15 7 4.16E- 01 5.6 LYM15 2 12371. 2 c 2.73 1 1.62E- 01 36.9 LYM99 12243. 1 G 9.09 6 4.92E- 01 4.9 LYM22 0 12851. 8 c 2.8 1.62E- 01 40.3 LYM20 6 12601. 2 G 9.11 5.79E- 01 5 LYM22 0 12851. 12 c 2.24 4 1.69E- 01 12.5 LYM25 0 12614. 2 G 8.90 5 6.05E- 01 2.7 LYM13 8 12561. 1 c 3.11 9 1.71E- 01 56.3 LYM15 9 13354. 5 G 8.84 5 6.87E- 01 2 LYM13 7 12151. 2 c 2.28 8 1.75E- 01 14.6 LYM23 6 12592. 3 G 9.01 3 8.02E- 01 3.9 LYM14 2 12802. 9 c 2.73 8 1.81E- 01 37.2 LYM17 5 12654. 4 G 8.97 4 8.11E- 01 3.5 LYM11 1 12252. 2 c 3.17 5 2.04E- 01 59.1 LYM25 0 12613. 4 G 8.91 3 8.18E- 01 2.8 LYM10 2 12222. 6 c 4.18 8 2.20E- 01 109.9 LYM91 13284. 4 G 8.87 7 8.65E- 01 2.4 LYM14 2 12801. 8 c 2.19 4 2.26E- 01 9.9 LYM20 6 12603. 1 G 8.75 8.71E- 01 0.9 LYM10 5 12294. 2 c 2.72 5 2.36E- 01 36.6 LYM6 11733. 2 G 8.89 1 8.75E- 01 2.5 LYM28 8 12743. 9 c 2.64 4 2.36E- 01 32.5 LYM14 7 12584. 4 G 8.74 7 9.59E- 01 0.9 LYM10 7 12633. 4 c 2.96 9 2.38E- 01 48.8 LYM17 5 12651. 4 G 8.74 8 9.72E- 01 0.9 LYM11 1 12251. 3 c 2.93 8 2.59E- 01 47.2 LYM17 5 12654. 6 G 8.69 7 9.75E- 01 0.3 LYM14 3 12524. 7 c 2.36 9 2.68E- 01 18.7 CONTR OL _ G 8.67 3 _ 0 LYM22 0 12852. 4 c 2.19 4 2.78E- 01 9.9 LYM10 7 12631. 4 H 14.1 58 3.91E- 03 35.7 LYM19 8 13002. 6 c 3.35 6 2.79E- 01 68.2 LYM14 7 12583. 3 H 13.5 34 8.52E- 03 29.7 LYM20 8 13012. 8 c 2.65 2.79E- 01 32.8 LYM23 6 12592. 3 H 13.4 87 9.09E- 03 29.3 LYM28 8 12743. 8 c 2.35 6 2.80E- 01 18.1 LYM90 12395. 1 H 13.7 8 1.94E- 02 32.1 LYM17 3 12982. 7 c 2.72 5 2.82E- 01 36.6 LYM12 9 12572. 4 H 12.8 66 2.83E- 02 23.3 LYM28 9 12491. 4 c 2.77 5 2.83E- 01 39.1 LYM20 6 12603. 1 H 13.4 05 4.09E- 02 28.5 LYM11 9 12463. 2 c 2.89 4 2.84E- 01 45 LYM14 7 12584. 4 H 12.6 29 4.40E- 02 21 LYM90 12392. 1 c 2.47 5 2.89E- 01 24 LYM88 12194. 2 H 12.5 15 4.87E- 02 20 LYM13 7 12153. 1 c 2.58 8 2.97E- 01 29.7 LYM6 11736. 1 H 12.3 91 5.69E- 02 18.8 LYM28 8 12741. 9 c 2.31 9 2.97E- 01 16.2 LYM89 12211. 4 H 12.7 71 6.74E- 02 22.4 LYM22 0 12852. 2 c 2.26 9 3.14E- 01 13.7 2016213786 11 Aug 2016 244 Gene name Event I D Mea n P value % incr. vs. cont. Gene name Event I D Mea n P value % incr. vs. cont. LYM90 12395. 3 H 14.3 16 6.99E- 02 37.2 LYM14 2 12803. 6 C 3.26 3 3.16E- 01 63.5 LYM73 12623. 2 H 12.2 01 8.98E- 02 16.9 LYM28 7 12773. 7 c 2.46 9 3.34E- 01 23.7 LYM86 12182. 3 H 12.1 23 9.17E- 02 16.2 LYM14 3 12521. 2 c 2.22 5 3.47E- 01 11.5 LYM12 8 12641. 3 H 12.2 49 l.OOE- 01 17.4 LYM15 2 12371. 3 c 2.62 5 3.48E- 01 31.6 LYM20 6 12603. 3 H 17.8 74 1.01E- 01 71.3 LYM21 2 13031. 6 c 2.46 9 3.77E- 01 23.7 LYM99 12243. 2 H 12.4 1 1.03E- 01 18.9 LYM17 3 12981. 6 c 2.47 5 3.79E- 01 24 LYM17 8 12163. 4 H 12.8 11 1.54E- 01 22.8 LYM25 5 13082. 7 c 2.16 9 3.81E- 01 8.7 LYM15 9 13354. 6 H 12.1 93 1.55E- 01 16.9 LYM10 5 12295. 2 c 2.84 4 3.99E- 01 42.5 LYM23 6 12594. 3 H 11.8 84 1.59E- 01 13.9 LYM13 7 12151. 4 c 3.00 6 4.08E- 01 50.7 LYM88 12193. 1 H 14.7 78 1.60E- 01 41.6 LYM11 9 12461. 1 c 2.28 1 4.10E- 01 14.3 LYM17 8 12164. 3 H 12.0 31 1.81E- 01 15.3 LYM19 8 13002. 5 c 2.61 9 4.15E- 01 31.2 LYM25 0 12614. 1 H 12.0 94 2.04E- 01 15.9 LYM11 1 12251. 4 c 3.27 5 4.15E- 01 64.1 LYM25 0 12613. 4 H 16.0 68 2.07E- 01 54 LYM13 8 12564. 1 c 2.26 3 4.26E- 01 13.4 LYM25 0 12613. 2 H 11.6 28 2.09E- 01 11.5 LYM20 8 13013. 6 c 2.81 9 4.34E- 01 41.3 LYM73 12623. 1 H 12.0 01 2.10E- 01 15 LYM18 3 12994. 8 c 2.25 6 4.45E- 01 13.1 LYM88 12191. 2 H 13.6 05 2.15E- 01 30.4 LYM15 3 12321. 2 c 2.63 8 4.50E- 01 32.2 LYM99 12243. 1 H 14.7 65 2.34E- 01 41.5 LYM14 3 12524. 2 c 2.51 9 4.55E- 01 26.2 LYM10 7 12633. 4 H 15.4 36 2.76E- 01 47.9 LYM28 9 12492. 2 c 2.48 1 4.61E- 01 24.4 LYM17 8 12163. 3 H 13.5 89 2.92E- 01 30.2 LYM24 2 13051. 8 c 2.40 6 4.75E- 01 20.6 LYM6 11735. 1 H 15.0 04 3.12E- 01 43.8 LYM18 3 12994. 7 c 2.43 1 4.77E- 01 21.8 LYM17 8 12161. 2 H 12.5 7 3.13E- 01 20.5 LYM25 5 13082. 5 c 2.16 3 4.79E- 01 8.4 LYM12 8 12642. 3 H 12.5 01 3.37E- 01 19.8 LYM28 7 12771. 6 c 2.23 1 4.83E- 01 11.8 LYM12 9 12573. 3 H 12.9 31 3.61E- 01 23.9 LYM17 3 12981. 5 c 2.33 1 4.84E- 01 16.8 LYM20 6 12601. 2 H 17.0 33 3.65E- 01 63.2 LYM28 8 12744. 6 c 2.20 6 4.86E- 01 10.6 LYM12 9 12573. 5 H 13.6 92 3.66E- 01 31.2 LYM22 0 12851. 11 c 2.22 9 5.02E- 01 11.7 LYM89 12214. 2 H 13.5 53 4.00E- 01 29.9 LYM29 1 12751. 7 c 2.20 6 5.06E- 01 10.6 2016213786 11 Aug 2016 245 Gene name Event I D Mea n P value % incr. vs. cont. Gene name Event I D Mea n P value % incr. vs. cont. LYM17 5 12651. 2 H 11.2 66 4.15E- 01 8 LYM25 5 13082. 9 C 2.39 4 5.08E- 01 20 LYM6 11734. 3 H 11.4 61 4.19E- 01 9.8 LYM22 0 12851. 13 c 2.17 5 5.17E- 01 9 LYM90 12392. 1 H 11.1 66 4.25E- 01 7 LYM29 1 12753. 6 c 2.22 5 5.20E- 01 11.5 LYM23 6 12591. 1 H 13.1 66 4.56E- 01 26.2 LYM44 11884. 1 c 2.15 5.32E- 01 7.8 LYM15 7 13341. 4 H 11.1 31 4.73E- 01 6.7 LYM13 0 12332. 2 c 2.21 9 5.39E- 01 11.2 LYM90 12393. 1 H 12.6 01 4.83E- 01 20.8 LYM19 7 12824. 7 c 2.62 5 5.42E- 01 31.6 LYM89 12214. 3 H 12.1 81 5.09E- 01 16.7 LYM11 9 12462. 2 c 2.92 5 5.45E- 01 46.6 LYM25 0 12614. 2 H 11.8 89 5.16E- 01 14 LYM24 2 13053. 7 c 2.09 4 5.53E- 01 4.9 LYM91 13284. 3 H 11.7 62 5.45E- 01 12.7 LYM44 11885. 4 c 2.35 5.71E- 01 17.8 LYM28 3 13304. 4 H 12.3 29 5.80E- 01 18.2 LYM13 7 12154. 5 c 2.31 9 5.87E- 01 16.2 LYM86 12183. 1 H 11.5 69 5.87E- 01 10.9 LYM13 0 12331. 3 c 2.5 6.12E- 01 25.3 LYM23 6 12592. 4 H 12.5 2 5.99E- 01 20 LYM14 2 12804. 3 c 2.15 6 6.19E- 01 8.1 LYM6 11733. 2 H 11.3 09 6.05E- 01 8.4 LYM27 0 12871. 7 c 2.2 6.64E- 01 10.3 LYM25 0 12611. 3 H 12.0 99 6.19E- 01 16 LYM17 4 12411. 3 c 2.15 6.66E- 01 7.8 LYM17 5 12654. 6 H 11.2 42 6.78E- 01 7.7 LYM18 3 12993. 7 c 2.22 5 6.77E- 01 11.5 LYM17 5 12654. 4 H 12.1 26 6.86E- 01 16.2 LYM13 8 12562. 2 c 2.18 1 6.86E- 01 9.3 LYM20 6 12603. 2 H 10.7 74 7.04E- 01 3.3 LYM21 2 13034. 8 c 2.31 3 6.90E- 01 15.9 LYM12 8 12641. 1 H 11.4 1 7.15E- 01 9.4 LYM27 0 12872. 7 c 2.16 9 7.14E- 01 8.7 LYM91 13283. 4 H 11.7 98 7.22E- 01 13.1 LYM13 0 12333. 1 c 2.29 4 7.33E- 01 15 LYM14 7 12584. 5 H 10.7 33 7.53E- 01 2.9 LYM15 3 12323. 2 c 2.18 8 7.44E- 01 9.6 LYM20 6 12601. 3 H 10.7 04 7.86E- 01 2.6 LYM10 6 12142. 1 c 2.36 3 7.50E- 01 18.4 LYM15 7 13342. 4 H 11.4 48 7.87E- 01 9.7 LYM13 0 12334. 1 c 2.05 7.51E- 01 2.7 LYM14 7 12583. 1 H 11.5 45 8.28E- 01 10.7 LYM19 8 13002. 8 c 2.21 3 7.61E- 01 10.9 LYM86 12183. 3 H 10.6 56 8.33E- 01 2.1 LYM28 7 12771. 7 c 2.06 3 8.00E- 01 3.4 LYM17 8 12164. 2 H 10.8 38 8.72E- 01 3.9 LYM44 11882. 1 c 2.10 6 8.42E- 01 5.6 LYM91 13283. 1 H 10.5 14 9.28E- 01 0.8 LYM19 8 13005. 6 c 2.06 3 8.64E- 01 3.4 2016213786 11 Aug 2016 246 Gene name Event I D Mea n P value % incr. vs. cont. Gene name Event I D Mea n P value % incr. vs. cont. LYM73 12622. 2 H 10.7 58 9.28E- 01 3.1 LYM29 1 12751. 2 C 2.04 2 8.80E- 01 2.3 LYM14 9 12344. 2 H 10.7 64 9.42E- 01 3.2 LYM20 1 12833. 7 c 2.08 8 8.82E- 01 4.6 CONTR OL _ H 10.4 34 _ 0 LYM44 11884. 3 c 2.06 9 9.05E- 01 3.7 LYM20 6 12603. 3 J 0.04 2 2.32E- 03 61.6 LYM44 11885. 3 c 2.01 3 9.12E- 01 0.9 LYM25 0 12613. 4 J 0.03 8 1.29E- 02 47.8 LYM90 12394. 2 c 2.00 6 9.59E- 01 0.5 LYM20 6 12601. 2 J 0.03 9 2.60E- 02 48.5 LYM25 5 13082. 8 c 2 9.86E- 01 0.2 LYM10 7 12633. 4 J 0.03 7 2.93E- 02 43.3 CONTR OL _ c 1.99 5 _ 0 LYM6 11735. 1 J 0.03 5 4.68E- 02 36.2 LYM10 2 12222. 2 D 0.26 5 6.00E- 06 40 LYM99 12243. 1 J 0.03 5 5.89E- 02 35.2 LYM28 8 12743. 9 D 0.26 4 1.70E- 05 39.2 LYM88 12191. 2 J 0.03 5 6.27E- 02 32.8 LYM17 3 12981. 6 D 0.24 8 9.60E- 05 31 LYM12 9 12573. 5 J 0.03 5 7.06E- 02 33.1 LYM13 8 12561. 3 D 0.31 1.04E- 04 63.6 LYM23 6 12592. 3 J 0.03 4 7.96E- 02 30.2 LYM10 7 12631. 4 D 0.23 9 1.13E- 04 26.3 LYM89 12214. 2 J 0.03 4 8.48E- 02 31.2 LYM10 5 12297. 2 D 0.24 2.13E- 04 26.7 LYM90 12395. 3 J 0.03 3 8.93E- 02 28.3 LYM13 0 12332. 1 D 0.28 3 2.74E- 03 49.6 LYM12 9 12572. 4 J 0.03 3 1.15E- 01 27.1 LYM28 9 12493. 1 D 0.27 2 3.81E- 03 43.6 LYM17 8 12163. 4 J 0.03 3 1.22E- 01 25.9 LYM13 0 12334. 1 D 0.23 4.39E- 03 21.6 LYM14 7 12583. 3 J 0.03 3 1.28E- 01 25.3 LYM10 2 12222. 1 D 0.22 8 5.99E- 03 20.7 LYM23 6 12592. 4 J 0.03 3 1.43E- 01 28.1 LYM25 5 13082. 8 D 0.25 2 6.25E- 03 33.3 LYM10 7 12631. 4 J 0.03 2 1.44E- 01 24.3 LYM10 6 12144. 4 D 0.25 8 6.35E- 03 36.4 LYM89 12211. 4 J 0.03 2 1.56E- 01 23.7 LYM10 7 12631. 2 D 0.21 6 6.37E- 03 14.2 LYM6 11736. 1 J 0.03 2 1.66E- 01 24.2 LYM15 3 12323. 2 D 0.28 2 7.68E- 03 49 LYM90 12395. 1 J 0.03 2 1.73E- 01 22.4 LYM10 5 12293. 1 D 0.27 8 1.12E- 02 47 LYM88 12193. 1 J 0.03 2 1.92E- 01 21.6 LYM20 1 12833. 7 D 0.21 2 1.16E- 02 12.1 LYM25 0 12611. 3 J 0.03 2 1.97E- 01 24.5 LYM11 9 12461. 4 D 0.30 1 1.22E- 02 59 LYM23 6 12591. 1 J 0.03 2 2.14E- 01 22.8 LYM28 7 12771. 6 D 0.21 9 1.38E- 02 15.5 LYM99 12243. 2 J 0.03 1 2.28E- 01 20.1 LYM10 5 12294. 2 D 0.24 8 1.47E- 02 31.1 2016213786 11 Aug 2016 247 Gene name Event I D Mea n P value % incr. vs. cont. Gene name Event I D Mea n P value % incr. vs. cont. LYM17 8 12161. 2 J 0.03 1 2.32E- 01 20.1 LYM17 3 12982. 6 D 0.21 5 1.80E- 02 13.7 LYM17 8 12163. 3 J 0.03 1 2.45E- 01 20 LYM13 7 12153. 1 D 0.22 7 2.52E- 02 19.8 LYM20 6 12603. 1 J 0.03 1 2.53E- 01 19 LYM15 2 12373. 1 D 0.23 4 2.75E- 02 23.5 LYM15 9 13354. 6 J 0.03 1 2.78E- 01 18.6 LYM27 0 12873. 6 D 0.25 2 2.79E- 02 33.2 LYM12 9 12573. 3 J 0.03 1 2.87E- 01 18.4 LYM13 8 12561. 1 D 0.39 9 4.37E- 02 110.9 LYM17 5 12654. 4 J 0.03 1 2.90E- 01 19.4 LYM28 7 12774. 6 D 0.20 6 4.37E- 02 00 00* LYM90 12392. 1 J 0.03 3.06E- 01 16.4 LYM24 2 13052. 5 D 0.21 2 4.61E- 02 12.1 LYM91 13284. 3 J 0.03 1 3.18E- 01 17.4 LYM13 7 12151. 4 D 0.27 5.04E- 02 42.4 LYM15 9 13354. 5 J 0.03 3.56E- 01 15.4 LYM10 0 12133. 3 D 0.20 5 5.59E- 02 8.1 LYM89 12214. 3 J 0.03 3.58E- 01 15.8 LYM13 7 12151. 2 D 0.25 6.45E- 02 32.1 LYM25 0 12613. 2 J 0.03 3.76E- 01 14.5 LYM28 9 12492. 2 D 0.24 6 6.50E- 02 29.9 LYM23 6 12594. 3 J 0.02 9 4.45E- 01 12.5 LYM17 4 12414. 3 D 0.32 7.11E- 02 69 LYM15 7 13342. 4 J 0.03 4.61E- 01 14 LYM15 3 12322. 1 D 0.21 8 7.32E- 02 15.3 LYM91 13283. 4 J 0.02 9 4.75E- 01 13.2 LYM11 1 12254. 4 D 0.23 7.53E- 02 21.3 LYM73 12623. 2 J 0.02 9 4.77E- 01 11.7 LYM11 9 12463. 2 D 0.30 2 7.64E- 02 59.5 LYM17 5 12651. 2 J 0.02 9 4.79E- 01 11.9 LYM10 6 12142. 2 D 0.30 7 7.80E- 02 62.1 LYM6 11733. 2 J 0.02 9 4.88E- 01 11.9 LYM15 3 12324. 2 D 0.27 7.86E- 02 42.8 LYM86 12182. 3 J 0.02 9 4.94E- 01 11 LYM10 6 12141. 4 D 0.21 9 7.93E- 02 15.7 LYM28 3 13304. 4 J 0.02 9 5.17E- 01 11.3 LYM21 2 13032. 8 D 0.23 9 8.15E- 02 26.2 LYM90 12393. 1 J 0.02 9 5.43E- 01 10.3 LYM11 9 12461. 1 D 0.30 8 8.59E- 02 62.9 LYM73 12623. 1 J 0.02 9 5.45E- 01 9.8 LYM20 1 12833. 9 D 0.20 3 8.86E- 02 7.2 LYM12 8 12642. 3 J 0.02 9 5.62E- 01 9.5 LYM10 0 12131. 3 D 0.20 9 9.17E- 02 10.3 LYM73 12622. 2 J 0.02 9 5.64E- 01 10.5 LYM28 8 12743. 8 D 0.23 6 9.25E- 02 24.6 LYM25 0 12614. 2 J 0.02 8 5.82E- 01 9.3 LYM22 0 12851. 8 D 0.28 6 9.36E- 02 51.1 LYM86 12183. 1 J 0.02 8 6.07E- 01 8.6 LYM10 2 12222. 3 D 0.22 9 1.07E- 01 20.9 LYM86 12183. 3 J 0.02 8 6.17E- 01 8.1 LYM10 5 12295. 2 D 0.26 9 1.09E- 01 41.9 2016213786 11 Aug 2016 248 Gene name Event I D Mea n P value % incr. vs. cont. Gene name Event I D Mea n P value % incr. vs. cont. LYM91 13283. 1 J 0.02 8 6.19E- 01 8 LYM17 4 12411. 2 D 0.27 6 1.10E-01 45.9 LYM25 0 12614. 1 J 0.02 8 6.33E- 01 7.7 LYM28 9 12491. 1 D 0.20 1 1.29E- 01 6.1 LYM15 7 13341. 4 J 0.02 8 6.74E- 01 7.2 LYM13 7 12151. 1 D 0.25 3 1.36E- 01 33.5 LYM17 8 12164. 3 J 0.02 8 6.96E- 01 6.2 LYM13 8 12562. 2 D 0.24 6 1.48E- 01 29.8 LYM12 8 12641. 1 J 0.02 8 6.98E- 01 6.8 LYM10 7 12632. 3 D 0.29 8 1.51E- 01 57.5 LYM14 7 12584. 4 J 0.02 8 7.13E- 01 5.8 LYM10 5 12294. 3 D 0.22 6 1.59E- 01 19.4 LYM17 5 12651. 4 J 0.02 8 7.62E- 01 5.8 LYM11 9 12462. 1 D 0.27 8 1.80E- 01 47 LYM15 9 13352. 4 J 0.02 7 7.80E- 01 4.6 LYM15 3 12324. 1 D 0.28 3 1.89E- 01 49.3 LYM88 12194. 2 J 0.02 7 7.86E- 01 4.4 LYM28 8 12743. 5 D 0.27 4 1.92E- 01 44.7 LYM17 5 12654. 6 J 0.02 7 8.01E- 01 4.3 LYM17 4 12412. 1 D 0.28 2 2.01E- 01 48.9 LYM14 7 12583. 1 J 0.02 7 8.50E- 01 3.7 LYM21 2 13031. 6 D 0.21 1 2.07E- 01 11.6 LYM14 9 12344. 2 J 0.02 7 8.67E- 01 3.2 LYM19 7 12821. 6 D 0.22 4 2.15E- 01 18.1 LYM12 8 12641. 3 J 0.02 7 8.88E- 01 2.2 LYM10 7 12631. 1 D 0.22 5 2.32E- 01 18.8 LYM88 12191. 1 J 0.02 7 9.00E- 01 2.1 LYM90 12395. 3 D 0.23 2.34E- 01 21.4 LYM20 6 12601. 3 J 0.02 7 9.12E- 01 1.8 LYM24 2 13051. 8 D 0.22 3 2.35E- 01 17.6 LYM89 12214. 4 J 0.02 6 9.25E- 01 1.5 LYM17 3 12981. 5 D 0.22 7 2.35E- 01 19.7 LYM14 7 12584. 5 J 0.02 6 9.58E- 01 0.9 LYM13 0 12332. 2 D 0.24 6 2.46E- 01 29.8 LYM17 8 12164. 2 J 0.02 6 9.69E- 01 0.6 LYM11 1 12251. 1 D 0.20 3 2.49E- 01 7.1 LYM14 7 12581. 4 J 0.02 6 9.95E- 01 0.1 LYM17 4 12411. 3 D 0.29 9 2.57E- 01 57.9 CONTR OL _ J 0.02 6 _ 0 LYM19 8 13005. 8 D 0.2 2.58E- 01 5.8 LYM15 7 13341. 4 K 0.69 7 6.89E- 02 22.1 LYM11 9 12462. 2 D 0.25 2.82E- 01 32 LYM88 12193. 1 K 0.61 7 4.88E- 01 8.1 LYM15 3 12321. 2 D 0.23 5 2.89E- 01 24.2 LYM73 12623. 2 K 0.60 5 6.11E- 01 6 LYM11 1 12252. 2 D 0.23 9 2.92E- 01 26.1 LYM10 7 12633. 4 K 0.60 4 6.16E- 01 5.8 LYM24 2 13053. 7 D 0.21 5 3.07E- 01 13.4 LYM15 9 13354. 8 K 0.60 3 6.36E- 01 5.6 LYM10 2 12221. 1 D 0.22 1 3.09E- 01 16.5 LYM90 12395. 3 K 0.6 6.64E- 01 5.1 LYM25 5 13082. 9 D 0.22 3.26E- 01 16 2016213786 11 Aug 2016 249 Gene name Event I D Mea n P value % incr. vs. cont. Gene name Event I D Mea n P value % incr. vs. cont. LYM17 5 12654. 6 K 0.6 6.86E- 01 5.2 LYM25 5 13082. 5 D 0.28 3.38E- 01 47.9 LYM90 12393. 2 K 0.59 6 7.01E- 01 4.4 LYM14 2 12802. 9 D 0.23 3.43E- 01 21.4 LYM20 6 12603. 3 K 0.59 7 7.01E- 01 4.6 LYM28 8 12741. 9 D 0.22 9 3.44E- 01 21.2 LYM25 0 12613. 4 K 0.59 5 7.13E- 01 4.2 LYM10 6 12144. 3 D 0.24 3.50E- 01 26.6 LYM12 9 12572. 4 K 0.59 4 7.18E- 01 4.1 LYM15 2 12371. 2 D 0.28 1 3.62E- 01 48.6 LYM6 11734. 3 K 0.59 4 7.26E- 01 4.1 LYM25 5 13082. 7 D 0.25 2 3.81E- 01 32.9 LYM15 7 13342. 4 K 0.59 4 7.43E- 01 4.1 LYM10 6 12142. 3 D 0.20 8 3.88E- 01 9.9 LYM15 9 13351. 1 K 0.59 2 7.73E- 01 3.7 LYM13 8 12564. 1 D 0.23 1 4.04E- 01 22 LYM90 12395. 1 K 0.58 6 8.23E- 01 2.6 LYM28 9 12493. 2 D 0.25 4 4.06E- 01 34.4 LYM15 9 13354. 5 K 0.58 7 8.28E- 01 2.9 LYM15 2 12371. 3 D 0.23 3 4.09E- 01 22.8 LYM90 12393. 1 K 0.58 6 8.34E- 01 2.6 LYM10 7 12632. 1 D 0.21 8 4.39E- 01 14.9 LYM99 12243. 1 K 0.58 2 8.78E- 01 1.9 LYM29 1 12754. 9 D 0.24 4.58E- 01 26.9 LYM23 6 12591. 1 K 0.58 1 8.85E- 01 1.8 LYM20 1 12834. 6 D 0.21 4.77E- 01 10.8 LYM99 12241. 1 K 0.57 8 9.22E- 01 1.2 LYM10 2 12222. 6 D 0.21 5 5.01E- 01 13.5 LYM6 11733. 2 K 0.57 7 9.25E- 01 1.1 LYM18 3 12994. 8 D 0.23 3 5.40E- 01 23.1 CONTR OL _ K 0.57 1 _ 0 LYM29 1 12753. 6 D 0.21 1 5.42E- 01 11.2 LYM20 6 12603. 3 L 2.30 3 1.34E- 03 74.3 LYM13 0 12331. 3 D 0.24 2 5.46E- 01 27.6 LYM25 0 12613. 4 L 2.05 4 9.93E- 03 55.4 LYM28 7 12771. 7 D 0.2 5.49E- 01 5.6 LYM20 6 12601. 2 L 2.13 7 1.29E- 02 61.7 LYM28 9 12491. 4 D 0.19 6 5.53E- 01 3.5 LYM10 7 12633. 4 L 1.94 7 3.16E- 02 47.3 LYM13 0 12333. 1 D 0.21 3 5.99E- 01 12.3 LYM6 11735. 1 L 1.89 8 4.09E- 02 43.6 LYM14 3 12524. 7 D 0.23 1 6.05E- 01 21.8 LYM99 12243. 1 L 1.86 1 4.63E- 02 40.8 LYM13 7 12154. 5 D 0.23 6.26E- 01 21.2 LYM88 12193. 1 L 1.80 6 6.33E- 02 36.6 LYM11 1 12251. 4 D 0.19 6 6.28E- 01 3.4 LYM90 12395. 3 L 1.79 4 6.59E- 02 35.8 LYM18 3 12993. 7 D 0.20 5 6.65E- 01 8.1 LYM10 7 12631. 4 L 1.73 3 1.04E- 01 31.1 LYM18 3 12993. 5 D 0.20 5 6.71E- 01 8.2 LYM88 12191. 2 L 1.73 3 1.17E- 01 31.1 LYM28 7 12773. 7 D 0.20 5 6.87E- 01 8.5 2016213786 11 Aug 2016 250 Gene name Event I D Mea n P value % incr. vs. cont. Gene name Event I D Mea n P value % incr. vs. cont. LYM12 9 12573. 5 L 1.74 9 1.18E- 01 32.3 LYM27 0 12871. 5 D 0.22 7.04E- 01 15.9 LYM23 6 12592. 3 L 1.72 4 1.21E- 01 30.4 LYM14 2 12801. 8 D 0.19 6 7.32E- 01 3.7 LYM90 12395. 1 L 1.70 8 1.26E- 01 29.2 LYM14 3 12524. 5 D 0.21 4 7.37E- 01 13.1 LYM14 7 12583. 3 L 1.69 6 1.38E- 01 28.3 LYM27 0 12871. 7 D 0.19 7 7.40E- 01 3.8 LYM89 12214. 2 L 1.71 5 1.44E- 01 29.8 LYM17 3 12981. 8 D 0.2 7.60E- 01 5.4 LYM12 9 12572. 4 L 1.66 3 1.82E- 01 25.9 LYM44 11885. 4 D 0.19 9 7.63E- 01 5.2 LYM17 8 12163. 3 L 1.66 7 1.88E- 01 26.2 LYM20 8 13012. 5 D 0.20 9 7.67E- 01 10.3 LYM20 6 12603. 1 L 1.65 1.92E- 01 24.8 LYM14 3 12521. 1 D 0.19 2 7.71E- 01 1.2 LYM23 6 12591. 1 L 1.66 1 2.18E- 01 25.7 LYM21 2 13034. 9 D 0.21 1 7.93E- 01 11.3 LYM89 12211. 4 L 1.61 2.51E- 01 21.8 LYM17 3 12982. 7 D 0.20 5 8.10E- 01 8.3 LYM23 6 12592. 4 L 1.62 4 2.79E- 01 22.9 LYM19 8 13004. 6 D 0.19 1 8.26E- 01 1 LYM12 9 12573. 3 L 1.60 2 2.85E- 01 21.2 LYM14 2 12804. 3 D 0.19 8 8.80E- 01 4.7 LYM17 8 12163. 4 L 1.57 9 3.05E- 01 19.5 LYM25 5 13081. 5 D 0.19 7 8.86E- 01 4.2 LYM6 11736. 1 L 1.57 9 3.15E- 01 19.5 LYM19 7 12822. 7 D 0.19 6 8.90E- 01 3.2 LYM99 12243. 2 L 1.56 2 3.36E- 01 18.2 LYM27 0 12871. 8 D 0.19 6 9.09E- 01 3.3 LYM14 7 12584. 4 L 1.54 7 3.54E- 01 17.1 LYM27 0 12872. 7 D 0.19 3 9.10E- 01 2 LYM15 9 13354. 6 L 1.55 8 3.54E- 01 17.9 LYM17 4 12414. 2 D 0.19 9.23E- 01 0.4 LYM17 8 12161. 2 L 1.55 6 3.55E- 01 17.7 LYM11 1 12251. 3 D 0.19 9.75E- 01 0.3 LYM90 12393. 1 L 1.56 1 3.57E- 01 18.1 LYM10 5 12297. 1 D 0.19 9.79E- 01 0.4 LYM88 12194. 2 L 1.54 6 3.63E- 01 17 LYM18 3 12994. 7 D 0.19 9.91E- 01 0.1 LYM25 0 12611. 3 L 1.54 6 4.06E- 01 17 CONTR OL _ D 0.18 9 _ 0 LYM12 8 12642. 3 L 1.52 4 4.21E- 01 15.3 LYM13 8 12561. 1 E 9 2.20E- 03 10.8 LYM28 3 13304. 4 L 1.53 2 4.27E- 01 15.9 LYM13 0 12332. 1 E 8.93 8 3.29E- 03 10 LYM17 5 12654. 4 L 1.54 4 4.29E- 01 16.8 LYM11 9 12461. 4 E 9 7.75E- 03 10.8 LYM73 12623. 2 L 1.52 4.29E- 01 15 LYM13 0 12334. 1 E 9 7.75E- 03 10.8 LYM25 0 12614. 1 L 1.51 6 4.32E- 01 14.7 LYM15 3 12323. 2 E 9 7.75E- 03 10.8 2016213786 11 Aug 2016 251 Gene name Event I D Mea n P value % incr. vs. cont. Gene name Event I D Mea n P value % incr. vs. cont. LYM89 12214. 3 L 1.52 3 4.32E- 01 15.2 LYM17 4 12412. 1 E 8.62 5 3.12E- 02 6.2 LYM86 12182. 3 L 1.51 4.46E- 01 14.2 LYM25 5 13082. 8 E 8.75 3.12E- 02 7.7 LYM73 12623. 1 L 1.49 8 4.75E- 01 13.3 LYM25 5 13082. 7 E 8.56 3 5.65E- 02 5.4 LYM17 8 12164. 3 L 1.48 9 4.93E- 01 12.7 LYM13 0 12332. 2 E 9 9.08E- 02 10.8 LYM25 0 12614. 2 L 1.49 9 4.94E- 01 13.4 LYM11 9 12461. 1 E 8.68 8 1.11E- 01 6.9 LYM23 6 12594. 3 L 1.49 5.02E- 01 12.7 LYM22 0 12851. 8 E 8.87 5 1.21E- 01 9.2 LYM91 13284. 3 L 1.49 2 5.06E- 01 12.9 LYM15 3 12324. 1 E 9.06 3 1.37E- 01 11.5 LYM91 13283. 4 L 1.49 5 5.25E- 01 13.1 LYM17 4 12414. 3 E 9.06 3 1.37E- 01 11.5 LYM12 8 12641. 3 L 1.46 8 5.48E- 01 11.1 LYM10 6 12141. 4 E 8.5 1.45E- 01 4.6 LYM6 11733. 2 L 1.45 9 5.91E- 01 10.4 LYM28 7 12771. 6 E 8.5 1.45E- 01 4.6 LYM25 0 12613. 2 L 1.45 4 5.93E- 01 10 LYM10 5 12297. 2 E 8.75 1.65E- 01 7.7 LYM17 5 12651. 2 L 1.45 2 6.05E- 01 9.9 LYM10 7 12631. 4 E 8.54 5 1.71E- 01 5.2 LYM17 5 12654. 6 L 1.45 2 6.13E- 01 9.9 LYM10 5 12295. 2 E 8.56 3 1.84E- 01 5.4 LYM15 7 13342. 4 L 1.45 4 6.29E- 01 10 LYM10 7 12631. 2 E 8.56 3 1.84E- 01 5.4 LYM12 8 12641. 1 L 1.44 6 6.33E- 01 9.4 LYM11 1 12252. 2 E 8.56 3 1.84E- 01 5.4 LYM86 12183. 1 L 1.43 2 6.61E- 01 8.4 LYM14 3 12524. 7 E 8.37 5 2.21E- 01 3.1 LYM15 7 13341. 4 L 1.43 2 6.63E- 01 8.3 LYM28 9 12493. 2 E 8.87 5 2.51E- 01 9.2 LYM14 7 12583. 1 L 1.43 1 7.05E- 01 8.2 LYM13 7 12153. 1 E 8.68 8 2.75E- 01 6.9 LYM90 12392. 1 L 1.40 6 7.24E- 01 6.4 LYM15 2 12371. 2 E 8.37 5 3.07E- 01 3.1 LYM6 11734. 3 L 1.40 5 7.36E- 01 6.3 LYM28 9 12491. 1 E 8.37 5 3.07E- 01 3.1 LYM73 12622. 2 L 1.40 2 7.68E- 01 6.1 LYM13 8 12562. 2 E 8.43 8 3.12E- 01 3.8 LYM20 6 12603. 2 L 1.36 1 8.74E- 01 3 LYM29 1 12754. 9 E 8.43 8 3.12E- 01 3.8 LYM91 13283. 1 L 1.34 3 9.30E- 01 1.6 LYM11 9 12462. 1 E 8.81 3 3.33E- 01 8.5 LYM14 9 12344. 2 L 1.34 2 9.41E- 01 1.6 LYM10 2 12222. 6 E 8.5 3.37E- 01 4.6 LYM17 8 12164. 2 L 1.33 7 9.51E- 01 1.2 LYM17 4 12411. 3 E 8.5 3.37E- 01 4.6 LYM86 12183. 3 L 1.33 9.73E- 01 0.6 LYM28 8 12741. 9 E 8.87 5 3.53E- 01 9.2 2016213786 11 Aug 2016 252 Gene name Event I D Mea n P value % incr. vs. cont. Gene name Event I D Mea n P value % incr. vs. cont. LYM15 9 13352. 4 L 1.33 9.74E- 01 0.6 LYM11 1 12254. 4 E 8.31 3 3.67E- 01 2.3 CONTR OL _ L 1.32 2 _ 0 LYM11 9 12462. 2 E 8.81 3 4.24E- 01 8.5 LYM20 6 12603. 3 M 0.28 8 1.32E- 03 69.7 LYM13 7 12154. 5 E 8.62 5 4.90E- 01 6.2 LYM25 0 12613. 4 M 0.25 7 1.04E- 02 51.3 LYM13 7 12151. 2 E 8.68 8 4.92E- 01 6.9 LYM20 6 12601. 2 M 0.26 7 1.40E- 02 57.5 LYM13 8 12561. 3 E 8.81 3 4.94E- 01 8.5 LYM10 7 12633. 4 M 0.24 3 3.48E- 02 43.4 LYM17 4 12411. 2 E 8.31 3 5.23E- 01 2.3 LYM6 11735. 1 M 0.23 7 4.53E- 02 39.8 LYM28 8 12743. 9 E 8.31 3 5.23E- 01 2.3 LYM99 12243. 1 M 0.23 3 5.12E- 02 37.1 LYM11 9 12463. 2 E 8.56 3 5.75E- 01 5.4 LYM88 12193. 1 M 0.22 6 7.05E- 02 33.1 LYM28 9 12493. 1 E 8.56 3 5.75E- 01 5.4 LYM90 12395. 3 M 0.22 4 7.35E- 02 32.2 LYM10 6 12144. 4 E 8.5 5.87E- 01 4.6 LYM10 7 12631. 4 M 0.21 7 1.17E- 01 27.7 LYM10 2 12222. 3 E 8.25 5.97E- 01 1.5 LYM88 12191. 2 M 0.21 7 1.33E- 01 27.6 LYM24 2 13051. 8 E 8.25 5.97E- 01 1.5 LYM12 9 12573. 5 M 0.21 9 1.34E- 01 28.8 LYM13 7 12151. 1 E 8.62 5 6.24E- 01 6.2 LYM23 6 12592. 3 M 0.21 5 1.38E- 01 27 LYM13 0 12331. 3 E 8.37 5 7.06E- 01 3.1 LYM90 12395. 1 M 0.21 4 1.44E- 01 25.9 LYM24 2 13052. 5 E 8.25 7.22E- 01 1.5 LYM14 7 12583. 3 M 0.21 2 1.57E- 01 24.9 LYM28 9 12491. 4 E 8.25 7.22E- 01 1.5 LYM89 12214. 2 M 0.21 4 1.65E- 01 26.3 LYM44 11885. 4 E 8.25 7.22E- 01 1.5 LYM17 8 12163. 4 M 0.21 1.72E- 01 24 LYM10 6 12144. 3 E 8.37 5 7.96E- 01 3.1 LYM12 9 12572. 4 M 0.20 8 2.08E- 01 22.6 LYM10 6 12142. 2 E 8.25 8.01E- 01 1.5 LYM17 8 12163. 3 M 0.20 8 2.16E- 01 22.8 LYM13 8 12564. 1 E 8.25 8.01E- 01 1.5 LYM20 6 12603. 1 M 0.20 6 2.21E- 01 21.5 LYM18 3 12993. 7 E 8.25 8.01E- 01 1.5 LYM23 6 12591. 1 M 0.20 8 2.50E- 01 22.4 LYM25 5 13082. 5 E 8.25 8.01E- 01 1.5 LYM89 12211. 4 M 0.20 1 2.90E- 01 18.6 LYM28 8 12743. 8 E 8.25 8.01E- 01 1.5 LYM17 5 12654. 4 M 0.20 3 3.08E- 01 19.7 LYM10 2 12222. 2 E 8.18 8 8.26E- 01 0.8 LYM23 6 12592. 4 M 0.20 3 3.19E- 01 19.7 LYM27 0 12873. 6 E 8.18 8 8.26E- 01 0.8 LYM12 9 12573. 3 M 0.2 3.27E- 01 18 LYM28 8 12743. 5 E 8.31 3 8.56E- 01 2.3 2016213786 11 Aug 2016 253 Gene name Event I D Mea n P value % incr. vs. cont. Gene name Event I D Mea n P value % incr. vs. cont. LYM6 11736. 1 M 0.19 7 3.63E- 01 16.4 LYM14 3 12524. 5 E 8.25 8.96E- 01 1.5 LYM99 12243. 2 M 0.19 5 3.88E- 01 15.1 LYM28 8 12744. 6 E 8.18 8 9.43E- 01 0.8 LYM15 9 13354. 6 M 0.19 5 4.08E- 01 14.8 CONTR OL _ E 8.12 5 _ 0 LYM14 7 12584. 4 M 0.19 3 4.09E- 01 14 LYM13 8 12561. 3 F 0.52 2.90E- 05 66 LYM17 8 12161. 2 M 0.19 4 4.10E- 01 14.6 LYM28 9 12493. 1 F 0.53 4.10E- 05 69.3 LYM90 12393. 1 M 0.19 5 4.11E- 01 15 LYM15 3 12323. 2 F 0.48 6 1.01E- 04 55.1 LYM88 12194. 2 M 0.19 3 4.20E- 01 13.9 LYM25 5 13082. 8 F 0.46 5 2.39E- 04 48.5 LYM25 0 12611. 3 M 0.19 3 4.65E- 01 13.9 LYM11 9 12463. 2 F 0.46 8 2.41E- 04 49.5 LYM12 8 12642. 3 M 0.19 4.85E- 01 12.3 LYM13 7 12151. 1 F 0.46 2.99E- 04 46.9 LYM28 3 13304. 4 M 0.19 2 4.90E- 01 12.9 LYM10 7 12631. 4 F 0.45 8 3.34E- 04 46.1 LYM73 12623. 2 M 0.19 4.95E- 01 12 LYM15 3 12324. 2 F 0.45 5 3.98E- 04 45.1 LYM89 12214. 3 M 0.19 4.97E- 01 12.2 LYM13 7 12151. 4 F 0.48 3 5.10E- 04 54.3 LYM25 0 12614. 1 M 0.18 9 4.99E- 01 11.7 LYM10 5 12293. 1 F 0.44 8 5.60E- 04 42.9 LYM86 12182. 3 M 0.18 9 5.15E- 01 11.2 LYM11 9 12462. 1 F 0.47 4 1.01E- 03 51.2 LYM73 12623. 1 M 0.18 7 5.48E- 01 10.4 LYM10 2 12222. 3 F 0.43 2 1.14E- 03 38 LYM25 0 12614. 2 M 0.18 7 5.67E- 01 10.4 LYM10 5 12297. 2 F 0.42 9 1.36E- 03 37 LYM17 8 12164. 3 M 0.18 6 5.69E- 01 9.7 LYM10 2 12221. 1 F 0.42 4 1.85E- 03 35.5 LYM23 6 12594. 3 M 0.18 6 5.78E- 01 9.8 LYM28 8 12743. 9 F 0.43 4 1.86E- 03 38.6 LYM91 13284. 3 M 0.18 7 5.80E- 01 10 LYM13 8 12562. 2 F 0.40 7 4.58E- 03 29.8 LYM91 13283. 4 M 0.18 7 5.98E- 01 10.1 LYM15 3 12321. 2 F 0.4 6.82E- 03 27.8 LYM12 8 12641. 3 M 0.18 4 6.31E- 01 8.2 LYM10 2 12222. 2 F 0.42 1 7.13E- 03 34.3 LYM6 11733. 2 M 0.18 2 6.76E- 01 7.5 LYM10 7 12631. 1 F 0.39 8 9.15E- 03 27.1 LYM25 0 12613. 2 M 0.18 2 6.80E- 01 7.1 LYM11 9 12461. 1 F 0.45 4 9.42E- 03 44.9 LYM17 5 12651. 2 M 0.18 1 6.92E- 01 7 LYM17 4 12412. 1 F 0.52 1.39E- 02 66 LYM17 5 12654. 6 M 0.18 1 7.00E- 01 7 LYM13 0 12332. 2 F 0.40 1 1.60E- 02 27.9 LYM15 7 13342. 4 M 0.18 2 7.13E- 01 7.1 LYM10 0 12133. 3 F 0.38 2 2.01E- 02 21.9 2016213786 11 Aug 2016 254 Gene name Event I D Mea n P value % incr. vs. cont. Gene name Event I D Mea n P value % incr. vs. cont. LYM12 8 12641. 1 M 0.18 1 7.21E- 01 6.5 LYM13 7 12153. 1 F 0.39 7 2.03E- 02 26.8 LYM86 12183. 1 M 0.17 9 7.55E- 01 5.5 LYM17 3 12982. 6 F 0.39 8 2.07E- 02 26.9 LYM15 7 13341. 4 M 0.17 9 7.57E- 01 5.5 LYM10 2 12222. 6 F 0.38 1 2.15E- 02 21.6 LYM15 9 13354. 5 M 0.17 8 7.87E- 01 4.8 LYM28 8 12743. 5 F 0.48 3 2.36E- 02 54.1 LYM14 7 12583. 1 M 0.17 9 7.91E- 01 5.4 LYM24 2 13051. 8 F 0.38 9 2.77E- 02 24.2 LYM90 12392. 1 M 0.17 6 8.29E- 01 3.6 LYM17 4 12414. 2 F 0.37 4 3.39E- 02 19.4 LYM6 11734. 3 M 0.17 6 8.39E- 01 3.5 LYM14 3 12521. 1 F 0.39 5 3.46E- 02 26 LYM73 12622. 2 M 0.17 5 8.64E- 01 3.3 LYM28 7 12771. 6 F 0.37 4 3.57E- 02 19.3 LYM20 6 12603. 2 M 0.17 9.89E- 01 0.2 LYM10 5 12295. 2 F 0.40 9 3.81E- 02 30.5 CONTR OL _ M 0.17 _ 0 LYM19 8 13005. 8 F 0.39 2 4.29E- 02 25.3 LYM20 6 12603. 3 N 0.24 9 2.57E- 02 31.4 LYM10 6 12142. 3 F 0.36 9 4.67E- 02 17.7 LYM25 0 12613. 4 N 0.24 5.39E- 02 27 LYM21 2 13031. 6 F 0.40 3 5.15E- 02 28.7 LYM10 7 12633. 4 N 0.23 9 8.02E- 02 26.2 LYM13 0 12334. 1 F 0.40 1 5.54E- 02 28.1 LYM88 12191. 2 N 0.23 1 1.01E- 01 22.1 LYM13 0 12332. 1 F 0.48 1 5.69E- 02 53.6 LYM6 11735. 1 N 0.23 1.18E- 01 21.4 LYM28 9 12493. 2 F 0.41 1 5.77E- 02 31.1 LYM20 6 12601. 2 N 0.23 6 1.28E- 01 24.9 LYM10 7 12632. 1 F 0.38 8 6.16E- 02 23.7 LYM23 6 12592. 3 N 0.22 5 1.46E- 01 19.1 LYM44 11882. 1 F 0.36 5 6.29E- 02 16.4 LYM23 6 12592. 4 N 0.22 8 1.67E- 01 20.7 LYM19 7 12821. 6 F 0.43 2 7.71E- 02 37.7 LYM12 9 12573. 5 N 0.22 2 2.12E- 01 17.1 LYM13 8 12561. 1 F 0.55 7 7.77E- 02 77.9 LYM99 12243. 1 N 0.22 1 2.18E- 01 16.8 LYM20 1 12834. 6 F 0.39 7.85E- 02 24.4 LYM25 0 12611. 3 N 0.22 2 2.41E- 01 17.3 LYM17 3 12981. 8 F 0.37 5 8.92E- 02 19.8 LYM15 9 13354. 5 N 0.21 8 2.47E- 01 15.2 LYM11 1 12254. 4 F 0.37 5 9.07E- 02 19.8 LYM15 7 13341. 4 N 0.21 6 2.84E- 01 14.2 LYM17 4 12411. 2 F 0.4 9.19E- 02 27.8 LYM91 13284. 3 N 0.21 8 2.91E- 01 15.2 LYM17 4 12414. 3 F 0.48 3 9.49E- 02 54.1 LYM89 12211. 4 N 0.21 1 3.54E- 01 11.7 LYM10 0 12131. 3 F 0.45 9 9.57E- 02 46.4 LYM12 9 12572. 4 N 0.21 1 3.67E- 01 11.3 LYM24 2 13052. 5 F 0.35 7 9.97E- 02 14 2016213786 11 Aug 2016 255 Gene name Event I D Mea n P value % incr. vs. cont. Gene name Event I D Mea n P value % incr. vs. cont. LYM15 9 13354. 6 N 0.21 3.95E- 01 11 LYM10 7 12632. 3 F 0.49 1 1.05E- 01 56.9 LYM90 12395. 3 N 0.20 9 4.04E- 01 10.4 LYM11 1 12251. 4 F 0.35 6 1.07E- 01 13.6 LYM17 8 12161. 2 N 0.21 4.14E- 01 10.9 LYM11 1 12252. 2 F 0.48 3 1.09E- 01 54.1 LYM73 12623. 2 N 0.20 9 4.32E- 01 10.2 LYM10 6 12141. 4 F 0.41 6 1.12E- 01 32.8 LYM23 6 12591. 1 N 0.21 1 4.35E- 01 11.3 LYM17 3 12981. 6 F 0.38 7 1.14E- 01 23.6 LYM20 6 12603. 1 N 0.20 9 4.38E- 01 10.3 LYM10 5 12294. 3 F 0.35 6 1.20E- 01 13.5 LYM17 8 12163. 4 N 0.20 8 4.45E- 01 9.8 LYM11 9 12461. 4 F 0.53 9 1.23E- 01 71.9 LYM6 11736. 1 N 0.20 8 4.50E- 01 9.8 LYM15 2 12373. 1 F 0.39 8 1.26E- 01 27.1 LYM99 12243. 2 N 0.20 7 4.52E- 01 9.6 LYM25 5 13082. 9 F 0.41 3 1.28E- 01 31.9 LYM89 12214. 2 N 0.20 8 4.71E- 01 10.1 LYM10 7 12633. 4 F 0.36 4 1.38E- 01 16.1 LYM23 6 12594. 3 N 0.20 6 5.03E- 01 8.7 LYM28 7 12774. 6 F 0.37 2 1.44E- 01 18.9 LYM88 12193. 1 N 0.20 6 5.05E- 01 8.7 LYM25 5 13082. 7 F 0.52 4 1.53E- 01 67.3 LYM17 8 12163. 3 N 0.20 6 5.07E- 01 8.9 LYM28 9 12491. 4 F 0.37 2 1.56E- 01 18.7 LYM17 5 12654. 4 N 0.20 6 5.32E- 01 9 LYM24 2 13054. 9 F 0.35 1.59E- 01 11.6 LYM17 5 12651. 2 N 0.20 5 5.44E- 01 8.2 LYM15 3 12322. 1 F 0.43 7 1.73E- 01 39.4 LYM73 12622. 2 N 0.20 7 5.48E- 01 9.2 LYM10 6 12144. 4 F 0.41 9 1.77E- 01 33.6 LYM90 12392. 1 N 0.20 3 5.60E- 01 7.2 LYM10 6 12144. 3 F 0.41 7 1.79E- 01 33.2 LYM12 9 12573. 3 N 0.20 4 5.70E- 01 7.8 LYM10 5 12294. 2 F 0.39 4 1.86E- 01 25.9 LYM25 0 12614. 2 N 0.20 3 5.87E- 01 7.2 LYM14 3 12524. 2 F 0.36 3 2.01E- 01 15.8 LYM14 7 12583. 3 N 0.20 2 5.92E- 01 6.9 LYM11 9 12462. 2 F 0.49 7 2.05E- 01 58.5 LYM91 13283. 4 N 0.20 4 5.95E- 01 7.7 LYM15 2 12371. 2 F 0.44 8 2.08E- 01 42.9 LYM90 12395. 1 N 0.20 2 6.07E- 01 6.6 LYM15 3 12324. 1 F 0.49 6 2.14E- 01 58.4 LYM6 11733. 2 N 0.20 1 6.29E- 01 6.3 LYM13 7 12151. 2 F 0.42 9 2.24E- 01 36.8 LYM25 0 12613. 2 N 0.20 1 6.31E- 01 6.1 LYM20 1 12833. 9 F 0.35 6 2.26E- 01 13.5 LYM15 9 13352. 4 N 0.20 1 6.42E- 01 6.1 LYM13 7 12154. 5 F 0.45 9 2.29E- 01 46.6 LYM15 7 13342. 4 N 0.20 2 6.50E- 01 6.9 LYM27 0 12872. 7 F 0.34 2 2.46E- 01 9.3 2016213786 11 Aug 2016 256 Gene name Event I D Mea n P value % incr. vs. cont. Gene name Event I D Mea n P value % incr. vs. cont. LYM6 11734. 3 N 0.2 6.63E- 01 5.5 LYM17 4 12411. 3 F 0.48 4 2.50E- 01 54.5 LYM17 5 12651. 4 N 0.19 8 7.57E- 01 4.9 LYM24 2 13053. 7 F 0.35 1 2.53E- 01 12 LYM10 7 12631. 4 N 0.19 6 7.70E- 01 3.7 LYM27 0 12873. 6 F 0.44 2.56E- 01 40.5 LYM89 12214. 3 N 0.19 3 8.96E- 01 1.7 LYM13 8 12564. 1 F 0.45 5 2.60E- 01 45.3 LYM28 3 13304. 4 N 0.19 2 9.03E- 01 1.7 LYM27 0 12872. 5 F 0.34 1 2.66E- 01 8.9 LYM88 12194. 2 N 0.19 1 9.26E- 01 1.2 LYM11 1 12251. 3 F 0.35 5 2.73E- 01 13.4 LYM90 12393. 1 N 0.19 2 9.27E- 01 1.2 LYM10 2 12222. 1 F 0.38 8 2.84E- 01 23.7 LYM73 12623. 1 N 0.19 1 9.45E- 01 0.9 LYM25 5 13082. 5 F 0.46 6 2.88E- 01 48.6 LYM17 5 12654. 6 N 0.19 1 9.48E- 01 0.9 LYM10 0 12134. 1 F 0.34 9 3.08E- 01 11.4 LYM25 6 13323. 3 N 0.19 9.77E- 01 0.4 LYM14 3 12524. 7 F 0.43 8 3.10E- 01 39.9 LYM12 8 12641. 1 N 0.19 9.78E- 01 0.4 LYM15 2 12371. 3 F 0.36 5 3.10E- 01 16.5 CONTR OL _ N 0.18 9 _ 0 LYM29 1 12753. 6 F 0.33 8 3.10E- 01 8 LYM10 7 12631. 4 O 1.77 3.57E- 03 32.1 LYM18 3 12994. 8 F 0.42 2 3.14E- 01 34.8 LYM17 8 12163. 4 O 1.70 8 5.93E- 03 27.5 LYM44 11885. 4 F 0.33 9 3.19E- 01 8.1 LYM14 7 12583. 3 o 1.69 2 7.49E- 03 26.3 LYM22 0 12851. 8 F 0.46 8 3.32E- 01 49.4 LYM23 6 12592. 3 o 1.68 6 7.99E- 03 25.9 LYM14 2 12804. 1 F 0.40 8 3.37E- 01 30.4 LYM90 12395. 1 o 1.72 3 2.51E- 02 28.6 LYM28 8 12741. 9 F 0.44 2 3.47E- 01 41 LYM12 9 12572. 4 o 1.60 8 3.01E- 02 20.1 LYM10 7 12631. 2 F 0.37 7 3.60E- 01 20.3 LYM14 7 12584. 4 o 1.57 9 4.98E- 02 17.9 LYM13 0 12331. 3 F 0.43 8 3.65E- 01 39.9 LYM20 6 12603. 1 o 1.67 6 5.34E- 02 25.1 LYM19 7 12821. 11 F 0.35 1 3.71E- 01 12.1 LYM88 12194. 2 o 1.56 4 5.43E- 02 16.8 LYM18 3 12994. 7 F 0.38 8 3.71E- 01 23.9 LYM6 11736. 1 o 1.54 9 6.34E- 02 15.6 LYM90 12395. 3 F 0.43 3 3.94E- 01 38.2 LYM89 12211. 4 o 1.59 6 8.59E- 02 19.2 LYM25 5 13081. 5 F 0.38 3.98E- 01 21.4 LYM90 12395. 3 o 1.78 9 8.97E- 02 33.6 LYM28 7 12771. 7 F 0.34 9 4.04E- 01 11.3 LYM86 12182. 3 o 1.51 5 1.09E- 01 13.1 LYM28 8 12744. 6 F 0.39 9 4.10E- 01 27.3 LYM73 12623. 2 o 1.52 5 1.09E- 01 13.9 LYM14 3 12524. 5 F 0.39 5 4.19E- 01 26 2016213786 11 Aug 2016 257 Gene name Event I D Mea n P value % incr. vs. cont. Gene name Event I D Mea n P value % incr. vs. cont. LYM20 6 12603. 3 O 2.23 4 1.15E- 01 66.8 LYM28 9 12491. 1 F 0.33 3 4.32E- 01 6.2 LYM12 8 12641. 3 o 1.53 1 1.26E- 01 14.3 LYM17 3 12981. 5 F 0.39 8 4.35E- 01 27.1 LYM99 12243. 2 o 1.55 1 1.32E- 01 15.8 LYM10 6 12142. 2 F 0.41 3 4.38E- 01 31.7 LYM88 12193. 1 o 1.84 7 1.84E- 01 37.9 LYM13 7 12152. 1 F 0.39 1 4.50E- 01 24.8 LYM15 9 13354. 6 o 1.52 4 1.99E- 01 13.8 LYM14 3 12521. 2 F 0.34 6 4.92E- 01 10.4 LYM23 6 12594. 3 o 1.48 6 2.04E- 01 10.9 LYM19 8 13004. 6 F 0.33 9 5.17E- 01 8.1 LYM25 0 12613. 4 o 2.00 9 2.25E- 01 49.9 LYM27 0 12871. 8 F 0.36 5.27E- 01 15 LYM17 8 12164. 3 o 1.50 4 2.35E- 01 12.3 LYM15 2 12372. 2 F 0.36 4 5.34E- 01 16.1 LYM88 12191. 2 o 1.70 1 2.49E- 01 27 LYM20 8 13012. 5 F 0.39 9 5.44E- 01 27.4 LYM99 12243. 1 o 1.84 6 2.59E- 01 37.8 LYM20 8 13013. 6 F 0.35 3 5.52E- 01 12.6 LYM25 0 12614. 1 o 1.51 2 2.61E- 01 12.9 LYM13 0 12333. 1 F 0.37 2 5.61E- 01 18.7 LYM73 12623. 1 o 1.5 2.71E- 01 12 LYM14 2 12801. 8 F 0.32 7 5.89E- 01 4.3 LYM25 0 12613. 2 o 1.45 4 2.72E- 01 8.5 LYM29 1 12751. 2 F 0.33 6 5.96E- 01 7.2 LYM10 7 12633. 4 o 1.93 2.97E- 01 44.1 LYM24 2 13051. 9 F 0.36 1 5.96E- 01 15.1 LYM17 8 12163. 3 o 1.69 9 3.27E- 01 26.8 LYM21 2 13032. 8 F 0.33 8 6.12E- 01 7.9 LYM6 11735. 1 o 1.87 5 3.35E- 01 40 LYM28 9 12492. 2 F 0.33 2 6.33E- 01 5.8 LYM17 8 12161. 2 o 1.57 1 3.67E- 01 17.3 LYM27 0 12871. 5 F 0.36 8 6.53E- 01 17.3 LYM20 6 12601. 2 o 2.12 9 3.80E- 01 58.9 LYM18 3 12993. 7 F 0.35 7 6.81E- 01 13.9 LYM12 8 12642. 3 o 1.56 3 3.92E- 01 16.7 LYM10 0 12133. 1 F 0.34 3 6.89E- 01 9.6 LYM12 9 12573. 5 o 1.71 1 3.99E- 01 27.8 LYM11 1 12251. 1 F 0.33 6.90E- 01 5.5 LYM12 9 12573. 3 o 1.61 6 4.06E- 01 20.7 LYM28 8 12743. 8 F 0.36 3 7.05E- 01 15.8 LYM89 12214. 2 o 1.69 4 4.34E- 01 26.5 LYM61 13174. 7 F 0.33 6 7.42E- 01 7.2 LYM23 6 12591. 1 o 1.64 6 4.95E- 01 22.9 LYM29 1 12754. 9 F 0.35 7.44E- 01 11.8 LYM6 11734. 3 o 1.43 3 5.31E- 01 7 LYM13 8 12566. 1 F 0.35 2 7.57E- 01 12.5 LYM90 12393. 1 o 1.57 5 5.32E- 01 17.6 LYM19 7 12824. 7 F 0.33 2 7.58E- 01 5.8 LYM17 5 12651. 2 o 1.40 8 5.50E- 01 5.1 LYM21 2 13034. 9 F 0.33 8 7.64E- 01 7.9 2016213786 11 Aug 2016 258 Gene name Event I D Mea n P value % incr. vs. cont. Gene name Event I D Mea n P value % incr. vs. cont. LYM17 5 12654. 4 O 1.59 6 5.60E- 01 19.1 LYM28 7 12773. 7 F 0.33 7 7.64E- 01 7.6 LYM89 12214. 3 o 1.52 3 5.70E- 01 13.7 LYM19 8 13002. 6 F 0.32 8 7.83E- 01 4.8 LYM90 12392. 1 o 1.39 6 5.76E- 01 4.2 LYM19 8 13002. 5 F 0.33 7 8.11E- 01 7.5 LYM25 0 12614. 2 o 1.48 6 5.89E- 01 11 LYM10 2 12221. 2 F 0.32 8.28E- 01 2.3 LYM91 13284. 3 o 1.47 6.23E- 01 9.8 LYM20 1 12831. 5 F 0.32 6 8.38E- 01 4.1 LYM28 3 13304. 4 o 1.54 1 6.30E- 01 15.1 LYM18 3 12993. 5 F 0.32 8.80E- 01 2.1 LYM15 7 13341. 4 o 1.39 1 6.32E- 01 3.9 LYM14 2 12802. 9 F 0.31 9 8.84E- 01 1.9 LYM23 6 12592. 4 o 1.56 5 6.43E- 01 16.8 LYM14 2 12804. 3 F 0.33 2 8.91E- 01 5.8 LYM86 12183. 1 o 1.44 6 6.73E- 01 8 LYM20 1 12833. 7 F 0.32 9.02E- 01 2.3 LYM25 0 12611. 3 o 1.51 2 6.74E- 01 12.9 LYM10 5 12297. 1 F 0.32 2 9.11E- 01 2.7 LYM6 11733. 2 o 1.41 4 7.15E- 01 5.5 LYM20 8 13011. 6 F 0.32 5 9.20E- 01 3.8 LYM91 13283. 4 o 1.47 5 7.75E- 01 10.1 LYM19 8 13005. 6 F 0.31 6 9.23E- 01 0.9 LYM17 5 12654. 6 o 1.40 5 7.80E- 01 4.9 LYM19 7 12822. 7 F 0.31 6 9.30E- 01 0.7 LYM12 8 12641. 1 o 1.42 6 7.91E- 01 6.5 LYM17 3 12982. 7 F 0.32 9.33E- 01 2.1 LYM15 9 13354. 5 o 1.36 5 8.31E- 01 1.9 LYM27 0 12871. 7 F 0.31 5 9.39E- 01 0.6 LYM15 7 13342. 4 o 1.43 1 8.44E- 01 6.8 LYM20 8 13012. 8 F 0.31 7 9.44E- 01 1.2 LYM14 7 12583. 1 o 1.44 3 8.70E- 01 7.7 LYM14 3 12523. 4 F 0.31 7 9.74E- 01 1.3 LYM20 6 12603. 2 o 1.34 7 9.41E- 01 0.5 LYM90 12392. 1 F 0.31 5 9.85E- 01 0.4 LYM17 8 12164. 2 o 1.35 5 9.61E- 01 1.1 LYM29 1 12751. 7 F 0.31 3 9.97E- 01 0 LYM14 7 12584. 5 o 1.34 2 9.84E- 01 0.2 CONTR OL _ F 0.31 3 _ 0 LYM73 12622. 2 o 1.34 5 9.91E- 01 0.4 LYM13 7 12154. 5 G 9.65 2 2.50E- 03 28.4 LYM14 9 12344. 2 o 1.34 6 9.92E- 01 0.5 LYM10 0 12131. 3 G 9.79 3 2.50E- 03 30.3 CONTR OL _ o 1.33 9 _ 0 LYM13 8 12566. 1 G 9.6 3.03E- 03 27.8 LYM17 8 12163. 4 P 2.40 5 5.91E- 03 17 LYM19 7 12821. 6 G 9.48 7 4.52E- 03 26.3 LYM23 6 12592. 3 P 2.37 1 7.03E- 03 15.4 LYM28 8 12744. 6 G 10.0 91 4.70E- 03 34.3 LYM90 12395. 3 P 2.35 6 1.03E- 02 14.6 LYM15 3 12324. 2 G 9.39 9 5.04E- 03 25.1 2016213786 11 Aug 2016 259 Gene name Event I D Mea n P value % incr. vs. cont. Gene name Event I D Mea n P value % incr. vs. cont. LYM88 12193. 1 P 2.44 5 2.73E- 02 19 LYM17 4 12412. 1 G 9.89 8 6.17E- 03 31.7 LYM89 12211. 4 P 2.28 6 3.08E- 02 11.2 LYM28 8 12743. 9 G 9.30 9 6.49E- 03 23.9 LYM14 7 12583. 3 P 2.32 1 3.39E- 02 12.9 LYM14 3 12524. 7 G 9.94 8 7.18E- 03 32.4 LYM20 6 12603. 3 P 2.67 3.75E- 02 29.9 LYM17 4 12411. 3 G 8.93 8 1.97E- 02 18.9 LYM20 6 12603. 1 P 2.36 5 4.22E- 02 15 LYM14 3 12524. 5 G 9.43 6 2.22E- 02 25.6 LYM15 9 13354. 6 P 2.24 4 6.96E- 02 9.2 LYM13 8 12561. 1 G 8.80 3 2.93E- 02 17.1 LYM73 12623. 2 P 2.22 8 8.37E- 02 8.4 LYM17 4 12414. 3 G 9.91 8 3.00E- 02 32 LYM99 12243. 2 P 2.21 7 9.87E- 02 7.8 LYM10 2 12222. 3 G 8.78 6 3.08E- 02 16.9 LYM90 12395. 1 P 2.34 8 1.12E- 01 14.2 LYM24 2 13052. 5 G 8.76 3 3.35E- 02 16.6 LYM6 11735. 1 P 2.45 9 1.30E- 01 19.6 LYM10 5 12295. 2 G 8.76 3.42E- 02 16.6 LYM14 7 12584. 4 P 2.19 7 1.35E- 01 6.9 LYM25 5 13082. 9 G 9.04 4 3.44E- 02 20.4 LYM88 12194. 2 P 2.19 4 1.52E- 01 6.8 LYM28 9 12491. 4 G 8.79 6 3.65E- 02 17.1 LYM10 7 12631. 4 P 2.30 2 1.87E- 01 12 LYM10 2 12221. 2 G 9.39 5 3.66E- 02 25 LYM6 11734. 3 P 2.25 5 1.95E- 01 9.7 LYM10 0 12131. 2 G 8.71 3 3.84E- 02 15.9 LYM6 11736. 1 P 2.17 5 1.97E- 01 5.8 LYM15 3 12321. 2 G 9.90 2 4.76E- 02 31.8 LYM73 12623. 1 P 2.20 1 2.31E- 01 7.1 LYM13 7 12151. 4 G 8.63 7 4.92E- 02 14.9 LYM23 6 12594. 3 P 2.18 1 2.39E- 01 6.1 LYM90 12395. 1 G 8.67 2 4.94E- 02 15.4 LYM25 0 12613. 4 P 2.57 3 2.42E- 01 25.2 LYM13 7 12152. 1 G 9.49 5.11E- 02 26.3 LYM17 8 12161. 2 P 2.33 7 2.59E- 01 13.7 LYM10 7 12631. 1 G 9.23 4 5.21E- 02 22.9 LYM10 7 12633. 4 P 2.57 1 2.61E- 01 25.1 LYM28 9 12493. 1 G 11.0 18 5.29E- 02 46.6 LYM17 8 12163. 3 P 2.33 5 2.65E- 01 13.6 LYM18 3 12994. 7 G 8.60 9 5.68E- 02 14.6 LYM12 9 12572. 4 P 2.18 2.78E- 01 6.1 LYM15 3 12323. 2 G 8.69 3 6.46E- 02 15.7 LYM25 0 12613. 2 P 2.18 6 2.87E- 01 6.3 LYM10 6 12142. 1 G 8.73 7 6.51E- 02 16.3 LYM86 12182. 3 P 2.14 9 3.06E- 01 4.5 LYM44 11885. 3 G 8.74 7.16E- 02 16.3 LYM88 12191. 2 P 2.36 2 3.07E- 01 14.9 LYM27 0 12872. 5 G 8.54 2 7.30E- 02 13.7 LYM25 0 12614. 1 P 2.15 6 3.08E- 01 4.9 LYM17 4 12414. 2 G 9.38 7.53E- 02 24.8 2016213786 11 Aug 2016 260 Gene name Event I D Mea n P value % incr. vs. cont. Gene name Event I D Mea n P value % incr. vs. cont. LYM12 9 12573. 5 P 2.34 3.12E- 01 13.8 LYM61 13174. 7 G 8.67 5 7.55E- 02 15.4 LYM12 9 12573. 3 P 2.27 9 3.13E- 01 10.9 LYM10 6 12142. 3 G 8.48 1 7.93E- 02 12.9 LYM99 12243. 1 P 2.45 2 3.36E- 01 19.3 LYM10 2 12221. 1 G 8.52 3 8.03E- 02 13.4 LYM17 8 12164. 3 P 2.14 6 3.40E- 01 4.4 LYM10 0 12134. 1 G 8.54 7 8.05E- 02 13.7 LYM12 8 12641. 3 P 2.14 9 3.45E- 01 4.6 LYM28 8 12741. 9 G 8.47 2 8.26E- 02 12.7 LYM20 6 12601. 2 P 2.58 8 3.87E- 01 25.9 LYM28 9 12491. 1 G 8.52 2 8.40E- 02 13.4 LYM15 7 13341. 4 P 2.14 3 4.06E- 01 4.2 LYM17 3 12981. 8 G 8.64 9 8.84E- 02 15.1 LYM25 0 12614. 2 P 2.21 6 4.21E- 01 7.8 LYM10 7 12632. 3 G 8.46 9 9.28E- 02 12.7 LYM90 12392. 1 P 2.12 1 4.64E- 01 3.2 LYM13 8 12561. 3 G 9.89 9.40E- 02 31.6 LYM89 12214. 2 P 2.29 6 4.65E- 01 11.7 LYM28 7 12771. 7 G 8.57 3 9.43E- 02 14.1 LYM15 9 13354. 5 P 2.14 3 4.69E- 01 4.2 LYM11 9 12461. 4 G 10.0 68 9.61E- 02 34 LYM23 6 12591. 1 P 2.30 5 5.02E- 01 12.1 LYM18 3 12994. 8 G 8.64 1 9.88E- 02 15 LYM90 12393. 1 P 2.20 2 5.67E- 01 7.1 LYM11 1 12252. 2 G 9.76 7 1.1 OE-01 30 LYM23 6 12592. 4 P 2.26 6 5.72E- 01 10.2 LYM17 3 12982. 7 G 8.45 6 1.1 OE-01 12.5 LYM17 5 12654. 4 P 2.24 7 5.93E- 01 9.3 LYM29 1 12753. 6 G 8.43 1.13E- 01 12.2 LYM25 0 12611. 3 P 2.25 2 6.16E- 01 9.6 LYM10 5 12293. 1 G 8.74 9 1.13E- 01 16.4 LYM89 12214. 3 P 2.19 2 6.24E- 01 6.6 LYM13 0 12331. 3 G 9.17 1 1.24E- 01 22 LYM91 13284. 3 P 2.21 6 6.26E- 01 7.8 LYM22 0 12852. 4 G 8.54 1.27E- 01 13.6 LYM28 3 13304. 4 P 2.18 4 6.55E- 01 6.3 LYM90 12393. 1 G 8.36 8 1.28E- 01 11.4 LYM12 8 12642. 3 P 2.14 3 6.86E- 01 4.3 LYM44 11884. 1 G 8.32 4 1.29E- 01 10.8 LYM17 5 12651. 2 P 2.09 1 6.92E- 01 1.7 LYM20 8 13014. 7 G 8.33 6 1.38E- 01 10.9 LYM91 13283. 4 P 2.17 7 7.80E- 01 5.9 LYM15 2 12371. 2 G 8.31 6 1.41E- 01 10.7 LYM15 7 13342. 4 P 2.12 9 8.55E- 01 3.6 LYM27 0 12871. 8 G 9.58 7 1.48E- 01 27.6 LYM86 12183. 1 P 2.08 6 8.93E- 01 1.5 LYM10 6 12144. 3 G 8.49 2 1.51E- 01 13 LYM12 8 12641. 1 P 2.08 1 9.09E- 01 1.3 LYM10 0 12133. 1 G 9.10 5 1.51E- 01 21.2 LYM6 11733. 2 P 2.08 9.12E- 01 1.2 LYM29 1 12751. 7 G 8.33 2 1.55E- 01 10.9 2016213786 11 Aug 2016 261 Gene name Event I D Mea n P value % incr. vs. cont. Gene name Event I D Mea n P value % incr. vs. cont. LYM15 9 13352. 4 P 2.07 9.20E- 01 0.7 LYM90 12395. 3 G 8.26 1 1.57E- 01 9.9 LYM73 12622. 2 P 2.08 5 9.45E- 01 1.4 LYM61 13171. 7 G 9.39 6 1.58E- 01 25 LYM14 7 12583. 1 P 2.09 5 9.49E- 01 1.9 LYM44 11884. 3 G 8.44 2 1.59E- 01 12.3 CONTR OL _ P 2.05 6 _ 0 LYM28 8 12743. 5 G 11.0 95 1.61E- 01 47.6 LYM16 5 12973. 8 A 91.4 61 5.84E- 02 2.5 LYM17 4 12411. 2 G 8.32 4 1.65E- 01 10.8 LYM14 2 12803. 6 A 91.2 85 7.62E- 02 2.3 LYM28 7 12774. 6 G 8.76 8 1.68E- 01 16.7 LYM24 2 13052. 5 A 91.1 79 8.25E- 02 2.1 LYM25 5 13082. 7 G 9.39 8 1.69E- 01 25.1 LYM14 2 12804. 4 A 91.5 2 1.16E- 01 2.5 LYM14 3 12521. 1 G 9.11 9 1.76E- 01 21.4 LYM22 0 12851. 7 A 92.0 43 1.54E- 01 3.1 LYM90 12392. 1 G 8.32 1.76E- 01 10.7 LYM14 2 12802. 9 A 90.7 34 1.57E- 01 1.6 LYM25 5 13082. 8 G 10.9 7 1.80E- 01 46 LYM22 0 12851. 13 A 90.6 71 1.90E- 01 1.6 LYM21 2 13034. 8 G 9.01 6 1.83E- 01 20 LYM27 0 12874. 7 A 90.1 87 3.71E- 01 1 LYM10 2 12222. 2 G 8.42 2 1.87E- 01 12.1 LYM21 2 13032. 8 A 90.2 58 4.05E- 01 1.1 LYM24 2 13054. 9 G 9.01 3 1.90E- 01 19.9 LYM16 5 12973. 6 A 90.3 5 4.28E- 01 1.2 LYM10 6 12141. 4 G 8.55 8 2.06E- 01 13.9 LYM22 3 12674. 2 A 90.2 59 4.31E- 01 1.1 LYM10 7 12631. 4 G 9.99 3 2.10E- 01 33 LYM27 0 12872. 5 A 90.3 41 4.99E- 01 1.2 LYM14 3 12521. 2 G 8.35 7 2.11E- 01 11.2 LYM22 0 12851. 11 A 90.4 46 5.73E- 01 1.3 LYM20 8 13013. 9 G 8.78 2 2.14E- 01 16.9 LYM20 3 12664. 1 A 89.7 91 5.92E- 01 0.6 LYM13 8 12562. 2 G 8.17 5 2.14E- 01 00 00* LYM16 5 12972. 6 A 89.9 24 6.77E- 01 0.7 LYM25 5 13082. 5 G 8.23 7 2.26E- 01 9.6 LYM14 2 12804. 3 A 89.6 63 6.98E- 01 0.4 LYM10 7 12633. 4 G 9.10 6 2.32E- 01 21.2 LYM20 3 12662. 3 A 89.5 92 7.80E- 01 0.4 LYM14 2 12804. 1 G 10.6 62 2.37E- 01 41.9 LYM21 2 13031. 5 A 89.7 6 8.24E- 01 0.6 LYM24 2 13051. 9 G 8.60 4 2.43E- 01 14.5 LYM16 5 12974. 5 A 89.4 51 8.70E- 01 0.2 LYM19 7 12822. 5 G 9.43 5 2.48E- 01 25.6 LYM14 2 12801. 8 A 89.8 33 9.02E- 01 0.6 LYM44 11882. 1 G 9.75 8 2.48E- 01 29.9 LYM22 0 12852. 4 A 89.4 91 9.29E- 01 0.2 LYM27 0 12871. 5 G 8.25 5 2.54E- 01 9.9 LYM20 7 13252. 2 A 89.4 64 9.67E- 01 0.2 LYM10 0 12133. 3 G 8.86 4 2.58E- 01 18 2016213786 11 Aug 2016 262 Gene name Event I D Mea n P value % incr. vs. cont. Gene name Event I D Mea n P value % incr. vs. cont. LYM21 2 13034. 9 A 89.3 17 9.73E- 01 0.1 LYM15 3 12324. 1 G 9.76 5 2.62E- 01 29.9 CONTR OL _ A 89.2 68 _ 0 LYM10 5 12297. 2 G 8.08 1 2.72E- 01 7.5 LYM20 3 12662. 3 B 0.35 7 2.54E- 03 16.5 LYM10 2 12222. 1 G 8.19 2.75E- 01 9 LYM14 2 12804. 4 B 0.34 6 2.59E- 02 13.1 LYM11 9 12463. 2 G 8.45 5 2.83E- 01 12.5 LYM27 0 12872. 8 B 0.32 1.49E- 01 4.5 LYM13 0 12333. 1 G 8.85 1 2.85E- 01 17.8 LYM20 7 13251. 5 B 0.32 2.19E- 01 4.5 LYM15 2 12372. 2 G 9.44 6 2.96E- 01 25.7 LYM24 2 13051. 8 B 0.32 3 2.70E- 01 5.5 LYM19 8 13002. 5 G 8.89 7 2.97E- 01 18.4 LYM21 2 13032. 8 B 0.32 8 3.94E- 01 6.9 LYM15 2 12373. 1 G 10.5 3 3.04E- 01 40.1 LYM16 5 12973. 5 B 0.31 1 5.21E- 01 1.6 LYM13 0 12332. 2 G 8.94 9 3.07E- 01 19.1 LYM16 5 12974. 5 B 0.34 3 5.67E- 01 11.8 LYM20 8 13013. 6 G 8.78 3.08E- 01 16.8 LYM22 0 12851. 11 B 0.32 4 5.74E- 01 5.9 LYM19 7 12824. 7 G 8.20 9 3.20E- 01 9.2 LYM16 5 12973. 6 B 0.33 9 5.91E- 01 10.8 LYM13 0 12334. 1 G 8.52 4 3.27E- 01 13.4 LYM21 2 13034. 9 B 0.32 2 6.03E- 01 5.1 LYM15 3 12322. 1 G 10.0 78 3.33E- 01 34.1 LYM16 5 12972. 6 B 0.31 6.28E- 01 1.2 LYM11 9 12462. 1 G 11.3 22 3.43E- 01 50.7 LYM22 3 12674. 5 B 0.31 1 6.63E- 01 1.6 LYM21 2 13031. 6 G 8.34 4 3.43E- 01 11 LYM24 2 13054. 9 B 0.32 1 6.88E- 01 4.7 LYM15 2 12371. 3 G 8.83 5 3.43E- 01 17.6 LYM22 3 12674. 2 B 0.31 8 7.66E- 01 3.9 LYM25 5 13081. 5 G 8.36 9 3.44E- 01 11.4 LYM21 2 13034. 8 B 0.31 4 8.88E- 01 2.6 LYM13 8 12564. 1 G 9.04 3 3.61E- 01 20.3 LYM14 2 12804. 3 B 0.30 8 9.13E- 01 0.4 LYM11 9 12462. 2 G 8.79 1 3.63E- 01 17 LYM27 0 12872. 7 B 0.30 8 9.59E- 01 0.4 LYM28 8 12743. 8 G 7.99 1 3.87E- 01 6.3 CONTR OL _ B 0.30 6 _ 0 LYM20 8 13011. 6 G 9.20 7 3.94E- 01 22.5 LYM27 0 12872. 8 C 3.21 4 1.73E- 02 9 LYM18 3 12993. 8 G 8.73 2 4.00E- 01 16.2 LYM24 2 13051. 8 C 3.05 6 2.19E- 01 3.6 LYM22 0 12851. 13 G 7.96 2 4.01E- 01 6 LYM20 3 12662. 3 C 3.39 4 2.48E- 01 15.1 LYM22 0 12852. 2 G 8.43 1 4.14E- 01 12.2 LYM16 5 12973. 6 C 3.36 3 2.58E- 01 14 LYM11 1 12251. 4 G 7.93 8 4.15E- 01 5.6 LYM22 0 12851. 11 C 3.08 8 3.21E- 01 4.7 LYM20 1 12833. 9 G 8.43 6 4.26E- 01 12.3 2016213786 11 Aug 2016 263 Gene name Event I D Mea n P value % incr. vs. cont. Gene name Event I D Mea n P value % incr. vs. cont. LYM27 0 12872. 7 C 3.02 5 4.73E- 01 2.6 LYM11 9 12461. 1 G 8.18 8 4.34E- 01 9 LYM20 7 13251. 5 c 3.08 1 4.87E- 01 4.5 LYM14 3 12524. 2 G 8.46 4 4.56E- 01 12.6 LYM14 2 12804. 3 c 3.00 6 4.98E- 01 1.9 LYM29 1 12754. 9 G 8.19 3 4.61E- 01 9 LYM16 5 12974. 5 c 3.31 9 5.38E- 01 12.5 LYM19 8 13005. 8 G 7.98 7 4.62E- 01 6.3 LYM21 2 13032. 8 c 3.14 4 5.50E- 01 6.6 LYM13 0 12332. 1 G 9.02 5 4.71E- 01 20.1 LYM24 2 13054. 9 c 3.07 5 6.60E- 01 4.3 LYM20 1 12834. 6 G 9.02 8 4.74E- 01 20.1 LYM14 2 12804. 4 c 3.11 9 6.89E- 01 5.7 LYM17 3 12981. 5 G 9.30 8 4.78E- 01 23.9 LYM21 2 13034. 9 c 3.06 9 7.34E- 01 4 LYM21 2 13034. 9 G 7.93 3 4.85E- 01 5.6 LYM21 2 13034. 8 c 3.08 1 7.88E- 01 4.5 LYM10 5 12294. 2 G 8.76 5 4.98E- 01 16.6 LYM16 5 12974. 6 c 2.98 1 8.42E- 01 1.1 LYM13 7 12151. 1 G 7.90 6 5.03E- 01 5.2 LYM22 3 12674. 2 c 2.98 1 8.42E- 01 1.1 LYM19 7 12821. 11 G 8.25 8 5.15E- 01 9.9 CONTR OL _ c 2.94 9 _ 0 LYM20 8 13012. 5 G 8.23 8 5.34E- 01 9.6 LYM16 5 12973. 8 D 0.32 2.37E- 03 23 LYM28 9 12493. 2 G 9.26 5 5.36E- 01 23.3 LYM20 7 13251. 6 D 0.30 5 1.11E- 02 17.4 LYM13 7 12153. 1 G 8.62 5.42E- 01 14.7 LYM16 5 12973. 6 D 0.36 3.31E- 02 38.6 LYM13 7 12151. 2 G 10.0 46 5.51E- 01 33.7 LYM20 7 13251. 4 D 0.29 5 5.21E- 02 13.4 LYM14 2 12801. 8 G 8.68 6 5.67E- 01 15.6 LYM20 3 12664. 1 D 0.29 5 1.18E- 01 13.7 LYM13 8 12562. 1 G 7.81 9 5.85E- 01 4.1 LYM14 2 12804. 4 D 0.32 7 1.20E- 01 25.7 LYM28 8 12744. 7 G 8.89 5 5.96E- 01 18.4 LYM22 0 12851. 7 D 0.28 9 1.21E- 01 11.3 LYM18 3 12991. 7 G 8.05 7 6.16E- 01 7.2 LYM21 2 13034. 9 D 0.32 1 1.28E- 01 23.6 LYM19 8 13002. 8 G 7.83 1 6.34E- 01 4.2 LYM20 3 12662. 3 D 0.39 2 1.71E- 01 50.9 LYM24 2 13053. 7 G 7.80 2 6.36E- 01 3.8 LYM16 5 12972. 6 D 0.33 7 2.51E- 01 29.6 LYM19 8 13004. 6 G 8.07 8 6.38E- 01 7.5 LYM14 2 12802. 9 D 0.28 8 2.59E- 01 10.9 LYM29 1 12751. 1 G 7.80 8 6.53E- 01 3.9 LYM22 0 12851. 11 D 0.27 5 2.93E- 01 5.7 LYM10 7 12631. 2 G 8.18 8 6.54E- 01 9 LYM16 5 12974. 5 D 0.36 6 3.60E- 01 40.7 LYM11 1 12251. 3 G 8.43 6.54E- 01 12.2 LYM14 2 12804. 3 D 0.28 3.67E- 01 7.9 LYM11 1 12254. 4 G 8.21 6.60E- 01 9.3 2016213786 11 Aug 2016 264 Gene name Event I D Mea n P value % incr. vs. cont. Gene name Event I D Mea n P value % incr. vs. cont. LYM21 2 13032. 8 D 0.31 3 3.99E- 01 20.5 LYM17 3 12982. 6 G 8.19 6 6.75E- 01 9.1 LYM20 7 13251. 5 D 0.27 1 4.58E- 01 4.2 LYM90 12394. 2 G 7.74 9 6.78E- 01 3.1 LYM21 2 13034. 8 D 0.32 6 4.77E- 01 25.5 LYM28 9 12492. 2 G 7.87 8 6.78E- 01 4.8 LYM24 2 13051. 8 D 0.31 7 5.01E- 01 22.2 LYM27 0 12873. 6 G 8.65 6 6.86E- 01 15.2 LYM24 2 13054. 9 D 0.29 6 5.23E- 01 14 LYM14 2 12804. 3 G 8.10 5 6.98E- 01 7.9 LYM14 2 12801. 8 D 0.27 7 5.35E- 01 6.7 LYM29 1 12751. 2 G 8.02 2 6.99E- 01 6.7 LYM27 0 12871. 7 D 0.26 6 6.43E- 01 2.4 LYM10 7 12632. 1 G 8.13 3 7.08E- 01 8.2 LYM16 5 12973. 5 D 0.28 5 6.48E- 01 9.5 LYM10 6 12142. 2 G 7.73 6 7.26E- 01 3 LYM20 3 12664. 2 D 0.27 3 7.59E- 01 5.1 LYM14 2 12803. 6 G 7.72 3 7.27E- 01 2.8 LYM14 2 12804. 1 D 0.27 1 8.59E- 01 4.2 LYM61 13174. 5 G 7.91 6 7.37E- 01 5.3 LYM27 0 12872. 7 D 0.26 2 8.71E- 01 0.8 LYM27 0 12872. 7 G 7.67 3 7.48E- 01 2.1 LYM22 3 12674. 2 D 0.26 1 9.23E- 01 0.5 LYM22 0 12851. 8 G 8.08 2 7.70E- 01 7.6 CONTR OL _ D 0.26 _ 0 LYM15 2 12373. 2 G 7.82 7.80E- 01 4.1 LYM16 5 12973. 8 E 8.62 5 4.10E- 04 12 LYM20 1 12831. 5 G 7.64 7.97E- 01 1.7 LYM21 2 13034. 9 E 8.43 8 1.77E- 03 9.6 LYM19 8 13005. 6 G 7.68 8 8.21E- 01 2.3 LYM16 5 12973. 6 E 8.75 4.04E- 03 13.6 LYM11 1 12254. 3 G 7.70 7 8.31E- 01 2.6 LYM16 5 12972. 6 E 8.31 3 5.10E- 03 7.9 LYM19 8 13002. 6 G 7.83 7 8.35E- 01 4.3 LYM14 2 12803. 6 E 8.18 8 1.61E- 02 6.3 LYM14 3 12523. 4 G 7.68 5 8.37E- 01 2.3 LYM20 7 13251. 5 E 8.18 8 1.61E- 02 6.3 LYM19 7 12824. 4 G 7.75 5 8.48E- 01 3.2 LYM20 3 12664. 1 E 9 5.72E- 02 16.9 LYM20 1 12833. 6 G 7.59 4 8.73E- 01 1.1 LYM22 0 12851. 11 E 8 8.14E- 02 3.9 LYM20 8 13012. 8 G 7.63 1 9.07E- 01 1.6 LYM14 2 12804. 4 E 8.31 3 1.00E- 01 7.9 LYM10 6 12144. 4 G 7.55 3 9.41E- 01 0.5 LYM21 2 13034. 8 E 8.43 8 2.09E- 01 9.6 LYM10 2 12222. 6 G 7.56 4 9.61E- 01 0.7 LYM20 3 12662. 3 E 8.62 5 2.09E- 01 12 LYM22 0 12851. 11 G 7.52 1 9.92E- 01 0.1 LYM16 5 12974. 5 E 8.31 3 2.60E- 01 7.9 CONTR OL _ G 7.51 4 _ 0 LYM21 2 13032. 8 E 8.31 3 2.60E- 01 7.9 LYM17 4 12414. 3 H 16.7 48 1.00E- 06 72.1 2016213786 11 Aug 2016 265 Gene name Event I D Mea n P value % incr. vs. cont. Gene name Event I D Mea n P value % incr. vs. cont. LYM22 0 12851. 7 E 8.25 3.59E- 01 7.1 LYM28 8 12743. 9 H 13.8 43 3.30E- 05 42.2 LYM27 0 12871. 7 E 7.93 8 4.08E- 01 3.1 LYM25 5 13082. 8 H 13.6 98 4.70E- 05 40.7 LYM14 2 12801. 8 E 8 4.22E- 01 3.9 LYM10 6 12144. 4 H 12.9 94 2.04E- 04 33.5 LYM20 7 13251. 6 E 8 4.22E- 01 3.9 LYM27 0 12873. 6 H 12.6 95 4.90E- 04 30.4 LYM14 2 12804. 1 E 8.12 5 4.47E- 01 5.5 LYM28 9 12492. 2 H 12.1 41 1.30E- 03 24.7 LYM22 3 12674. 2 E 7.81 3 5.05E- 01 1.4 LYM10 5 12294. 2 H 11.9 67 1.87E- 03 22.9 LYM27 0 12872. 5 E 8.12 5 5.48E- 01 5.5 LYM13 0 12332. 1 H 15.4 26 3.71E- 03 58.5 LYM24 2 13051. 8 E 8.06 3 5.55E- 01 4.7 LYM15 3 12323. 2 H 14.6 28 4.86E- 03 50.3 LYM14 2 12802. 9 E 8 5.67E- 01 3.9 LYM13 0 12334. 1 H 12.6 21 5.52E- 03 29.7 LYM20 3 12664. 2 E 7.75 8.10E- 01 0.6 LYM13 7 12153. 1 H 11.4 76 7.32E- 03 17.9 LYM14 2 12804. 3 E 7.81 3 8.76E- 01 1.4 LYM15 3 12324. 2 H 13.5 15 7.63E- 03 38.9 LYM24 2 13052. 5 E 7.75 8.83E- 01 0.6 LYM17 3 12981. 6 H 11.7 01 8.10E- 03 20.2 LYM22 0 12851. 13 E 7.75 9.38E- 01 0.6 LYM13 8 12561. 1 H 21.8 1 8.93E- 03 124.1 LYM24 2 13054. 9 E 7.75 9.50E- 01 0.6 LYM28 9 12493. 1 H 14.5 47 1.07E- 02 49.5 CONTR OL _ E 7.70 1 _ 0 LYM11 9 12461. 4 H 16.2 44 1.16E- 02 66.9 LYM16 5 12973. 6 F 0.59 6 7.95E- 02 13.5 LYM10 2 12222. 2 H 13.4 08 1.46E- 02 37.7 LYM14 2 12804. 4 F 0.59 2 1.09E- 01 12.7 LYM10 2 12222. 3 H 11.6 38 1.94E- 02 19.6 LYM16 5 12973. 8 F 0.58 6 1.31E- 01 11.7 LYM10 5 12297. 2 H 12.7 83 2.07E- 02 31.3 LYM20 3 12664. 1 F 0.63 3 2.49E- 01 20.5 LYM10 7 12631. 2 H 11.0 91 2.27E- 02 14 LYM20 3 12662. 3 F 0.69 4 2.67E- 01 32.3 LYM13 8 12561. 3 H 16.5 24 3.41E- 02 69.8 LYM24 2 13051. 8 F 0.58 2 3.48E- 01 10.9 LYM11 9 12461. 1 H 15.5 82 6.22E- 02 60.1 LYM20 7 13251. 6 F 0.56 1 3.53E- 01 6.8 LYM10 5 12293. 1 H 13.5 58 6.63E- 02 39.3 LYM24 2 13054. 9 F 0.57 4.74E- 01 8.5 LYM10 6 12141. 4 H 11.1 04 7.61E- 02 14.1 LYM21 2 13034. 8 F 0.58 7 5.70E- 01 11.8 LYM21 2 13032. 8 H 11.5 93 7.79E- 02 19.1 LYM16 5 12972. 6 F 0.55 7 5.84E- 01 6 LYM11 9 12463. 2 H 15.3 35 8.15E- 02 57.6 LYM16 5 12974. 5 F 0.57 8 6.31E- 01 10 LYM10 5 12295. 2 H 12.8 55 8.74E- 02 32.1 2016213786 11 Aug 2016 266 Gene name Event I D Mea n P value % incr. vs. cont. Gene name Event I D Mea n P value % incr. vs. cont. LYM21 2 13034. 9 F 0.54 7.29E- 01 2.9 LYM17 3 12982. 6 H 10.6 59 8.92E- 02 9.5 LYM14 2 12804. 1 F 0.54 1 7.41E- 01 3 LYM11 1 12254. 4 H 11.4 42 9.17E- 02 17.6 LYM20 7 13251. 4 F 0.53 8 7.77E- 01 2.4 LYM17 4 12411. 2 H 13.7 91 1.04E- 01 41.7 LYM16 5 12973. 5 F 0.53 4 8.72E- 01 1.6 LYM22 0 12851. 8 H 15.0 87 1.22E- 01 55 LYM21 2 13032. 8 F 0.52 7 9.61E- 01 0.5 LYM10 5 12294. 3 H 10.8 46 1.28E- 01 11.4 CONTR OL _ F 0.52 5 _ 0 LYM13 7 12151. 4 H 13.0 64 1.38E- 01 34.2 LYM20 3 12662. 3 G 10.7 73 2.09E- 01 11.7 LYM17 4 12412. 1 H 14.7 75 1.64E- 01 51.8 LYM22 3 12671. 2 G 10.2 17 5.89E- 01 6 LYM10 6 12142. 2 H 15.8 71 1.65E- 01 63.1 LYM21 2 13034. 8 G 10.0 24 7.08E- 01 4 LYM13 0 12332. 2 H 12.9 21 1.74E- 01 32.8 LYM14 2 12804. 1 G 9.73 1 8.40E- 01 0.9 LYM24 2 13051. 8 H 11.3 19 1.75E- 01 16.3 LYM27 0 12871. 7 G 9.68 1 9.77E- 01 0.4 LYM10 7 12632. 3 H 14.7 68 1.82E- 01 51.7 CONTR OL _ G 9.64 1 _ 0 LYM15 2 12373. 1 H 11.0 22 2.05E- 01 13.2 LYM16 5 12973. 6 H 16.9 61 8.98E- 04 45.3 LYM13 7 12151. 1 H 12.6 58 2.07E- 01 30 LYM16 5 12973. 8 H 14.7 78 4.30E- 03 26.6 LYM15 3 12324. 1 H 14.1 97 2.09E- 01 45.9 LYM20 7 13251. 6 H 14.3 26 3.04E- 02 22.7 LYM10 7 12631. 4 H 11.1 47 2.14E- 01 14.5 LYM14 2 12804. 4 H 15.5 89 3.30E- 02 33.5 LYM11 9 12462. 1 H 14.8 06 2.26E- 01 52.1 LYM20 3 12664. 1 H 14.0 85 5.01E- 02 20.7 LYM13 8 12562. 2 H 12.0 98 2.27E- 01 24.3 LYM21 2 13034. 9 H 14.9 93 9.74E- 02 28.4 LYM28 9 12491. 1 H 10.6 24 2.38E- 01 9.1 LYM20 3 12662. 3 H 19.3 28 1.50E- 01 65.6 LYM17 4 12411. 3 H 15.5 39 2.45E- 01 59.6 LYM16 5 12972. 6 H 15.6 17 2.04E- 01 33.8 LYM13 7 12151. 2 H 12.6 94 2.45E- 01 30.4 LYM20 7 13251. 5 H 12.7 19 2.12E- 01 9 LYM15 3 12322. 1 H 10.7 28 2.52E- 01 10.2 LYM22 0 12851. 7 H 13.0 19 2.47E- 01 11.5 LYM11 1 12252. 2 H 12.3 72 2.55E- 01 27.1 LYM20 7 13251. 4 H 13.2 24 2.75E- 01 13.3 LYM28 8 12743. 8 H 11.7 15 2.62E- 01 20.4 LYM22 0 12851. 11 H 12.5 36 3.05E- 01 7.4 LYM28 7 12774. 6 H 10.4 25 2.70E- 01 7.1 LYM16 5 12974. 5 H 17.1 37 3.08E- 01 46.8 LYM28 8 12743. 5 H 14.2 37 2.75E- 01 46.3 LYM21 2 13032. 8 H 14.5 04 4.27E- 01 24.3 LYM24 2 13052. 5 H 10.9 22 2.99E- 01 12.2 2016213786 11 Aug 2016 267 Gene name Event I D Mea n P value % incr. vs. cont. Gene name Event I D Mea n P value % incr. vs. cont. LYM21 2 13034. 8 H 15.1 69 4.30E- 01 29.9 LYM10 7 12631. 1 H 11.2 58 3.08E- 01 15.7 LYM14 2 12801. 8 H 12.8 3 4.42E- 01 9.9 LYM10 0 12131. 3 H 10.8 77 3.20E- 01 11.7 LYM14 2 12802. 9 H 12.8 29 4.65E- 01 9.9 LYM28 9 12491. 4 H 10.5 77 3.20E- 01 8.7 LYM24 2 13054. 9 H 13.5 01 4.67E- 01 15.7 LYM90 12395. 3 H 11.5 46 3.34E- 01 18.6 LYM24 2 13051. 8 H 14.4 12 5.21E- 01 23.5 LYM10 2 12222. 1 H 10.7 14 3.34E- 01 10.1 LYM14 2 12804. 3 H 12.4 9 5.36E- 01 7 LYM19 7 12821. 6 H 11.0 8 3.37E- 01 13.8 LYM16 5 12973. 5 H 12.6 26 6.39E- 01 8.2 LYM25 5 13082. 7 H 13.6 91 3.37E- 01 40.7 LYM22 3 12674. 2 H 11.9 68 7.07E- 01 2.5 LYM11 9 12462. 2 H 13.5 06 3.41E- 01 38.8 LYM14 2 12804. 1 H 12.3 27 8.32E- 01 5.6 LYM15 2 12371. 2 H 14.3 31 3.57E- 01 47.2 LYM20 3 12664. 2 H 12.0 83 8.49E- 01 3.5 LYM15 3 12321. 2 H 12.3 6 3.58E- 01 27 LYM27 0 12871. 7 H 11.7 94 8.95E- 01 1 LYM28 7 12771. 6 H 10.2 73 3.68E- 01 5.5 LYM27 0 12872. 7 H 11.7 54 9.22E- 01 0.7 LYM28 9 12493. 2 H 14.0 17 3.69E- 01 44 CONTR OL _ H 11.6 73 _ 0 LYM10 6 12144. 3 H 12.3 56 3.75E- 01 26.9 LYM20 3 12662. 3 J 0.04 6 2.04E- 03 50.5 LYM25 5 13082. 5 H 14.4 81 3.83E- 01 48.8 LYM16 5 12973. 6 J 0.04 2 6.22E- 03 38.8 LYM28 8 12741. 9 H 11.8 34 4.12E- 01 21.6 LYM16 5 12974. 5 J 0.04 3 1.62E- 02 41 LYM13 8 12564. 1 H 11.6 16 4.26E- 01 19.3 LYM16 5 12972. 6 J 0.03 9 4.57E- 02 29.2 LYM29 1 12754. 9 H 12.3 03 4.35E- 01 26.4 LYM14 2 12804. 4 J 0.03 8 6.13E- 02 25.6 LYM10 2 12221. 1 H 10.8 24 4.81E- 01 11.2 LYM21 2 13034. 8 J 0.03 8 9.39E- 02 26.4 LYM15 2 12371. 3 H 11.5 86 4.88E- 01 19 LYM21 2 13034. 9 J 0.03 7 1.03E- 01 22.1 LYM25 5 13082. 9 H 10.8 51 5.04E- 01 11.5 LYM16 5 12973. 8 J 0.03 7 1.07E- 01 21.7 LYM13 0 12331. 3 H 12.7 14 5.44E- 01 30.6 LYM21 2 13032. 8 J 0.03 7 1.53E- 01 20.9 LYM21 2 13031. 6 H 10.1 72 5.47E- 01 4.5 LYM24 2 13051. 8 J 0.03 7 1.67E- 01 20.7 LYM14 3 12524. 7 H 11.9 39 5.72E- 01 22.7 LYM20 7 13251. 6 J 0.03 6 1.84E- 01 17.5 LYM17 3 12981. 5 H 10.6 49 5.74E- 01 9.4 LYM20 3 12664. 1 J 0.03 5 2.26E- 01 16 LYM10 6 12142. 3 H 10.1 39 5.74E- 01 4.2 LYM20 7 13251. 4 J 0.03 5 2.79E- 01 14.1 LYM14 2 12802. 9 H 11.0 41 5.91E- 01 13.4 2016213786 11 Aug 2016 268 Gene name Event I D Mea n P value % incr. vs. cont. Gene name Event I D Mea n P value % incr. vs. cont. LYM14 2 12802. 9 J 0.03 5 3.01E- 01 14 LYM19 8 13005. 8 H 10.1 83 5.92E- 01 4.6 LYM22 0 12851. 7 J 0.03 5 3.06E- 01 13.9 LYM10 2 12222. 6 H 10.7 59 6.01E- 01 10.5 LYM24 2 13054. 9 J 0.03 4 3.48E- 01 13 LYM13 7 12154. 5 H 12.3 54 6.05E- 01 26.9 LYM16 5 12973. 5 J 0.03 4 3.92E- 01 12.3 LYM20 1 12834. 6 H 10.2 94 7.03E- 01 5.8 LYM14 2 12804. 3 J 0.03 3 4.73E- 01 9.4 LYM18 3 12994. 8 H 11.3 14 7.10E- 01 16.2 LYM20 3 12664. 2 J 0.03 3 5.96E- 01 7.4 LYM44 11885. 4 H 10.2 56 7.27E- 01 5.4 LYM22 0 12851. 11 J 0.03 2 6.35E- 01 6.1 LYM24 2 13053. 7 H 10.0 93 7.36E- 01 3.7 LYM14 2 12804. 1 J 0.03 2 6.79E- 01 6 LYM29 1 12753. 6 H 10.3 37 7.51E- 01 6.2 LYM24 2 13053. 7 J 0.03 2 6.82E- 01 5.5 LYM14 3 12524. 5 H 10.9 26 7.58E- 01 12.2 LYM14 2 12801. 8 J 0.03 1 7.91E- 01 3.5 LYM20 1 12833. 7 H 9.92 7 7.73E- 01 2 LYM27 0 12871. 7 J 0.03 1 8.11E- 01 3 LYM13 0 12333. 1 H 10.3 53 7.92E- 01 6.4 LYM22 3 12674. 2 J 0.03 1 9.08E- 01 1.6 LYM28 7 12773. 7 H 10.3 4 8.02E- 01 6.2 LYM20 7 13251. 5 J 0.03 1 9.50E- 01 0.8 LYM18 3 12993. 7 H 10.2 25 8.25E- 01 5 CONTR OL _ J 0.03 _ 0 LYM18 3 12994. 7 H 9.92 4 8.96E- 01 2 LYM20 7 13251. 5 K 0.59 4 5.66E- 02 26.1 LYM21 2 13034. 9 H 10.1 57 9.25E- 01 4.4 LYM16 5 12973. 6 K 0.57 8 9.58E- 02 22.8 LYM20 8 13012. 5 H 9.99 2 9.35E- 01 2.7 LYM20 3 12664. 1 K 0.57 5 1.28E- 01 22.2 CONTR OL _ H 9.73 3 _ 0 LYM20 3 12662. 3 K 0.56 4 1.31E- 01 19.8 LYM13 8 12561. 1 J 0.04 4 0.00E +00 114 LYM22 0 12851. 7 K 0.54 3 2.71E- 01 15.2 LYM11 9 12461. 1 J 0.03 7 1.00E- 06 76.2 LYM20 7 13251. 6 K 0.53 6 3.18E- 01 13.9 LYM13 8 12561. 3 J 0.03 5 5.00E- 06 69.7 LYM21 2 13034. 9 K 0.53 3.55E- 01 12.6 LYM17 4 12414. 3 J 0.03 6 1.20E- 05 71.7 LYM21 2 13034. 8 K 0.53 3 3.98E- 01 13.1 LYM11 9 12461. 4 J 0.03 4 1.30E- 05 64.1 LYM16 5 12974. 5 K 0.52 2 4.02E- 01 10.8 LYM11 9 12463. 2 J 0.03 4 1.90E- 05 64.3 LYM16 5 12973. 8 K 0.52 2 4.55E- 01 10.8 LYM10 7 12632. 3 J 0.03 4 7.40E- 05 63 LYM22 3 12672. 5 K 0.51 3 5.04E- 01 8.9 LYM10 6 12142. 2 J 0.03 4 1.01E- 04 65.8 LYM14 2 12804. 1 K 0.51 4 5.15E- 01 9.2 LYM15 3 12324. 1 J 0.03 3 1.07E- 04 60.5 2016213786 11 Aug 2016 269 Gene name Event I D Mea n P value % incr. vs. cont. Gene name Event I D Mea n P value % incr. vs. cont. LYM22 3 12671. 2 K 0.51 2 5.28E- 01 00 00* LYM15 3 12323. 2 J 0.03 2 1.80E- 04 53.5 LYM24 2 13054. 9 K 0.50 4 6.16E- 01 7.1 LYM13 7 12151. 4 J 0.03 1 1.99E- 04 50.4 LYM21 2 13032. 8 K 0.50 1 6.28E- 01 6.4 LYM22 0 12851. 8 J 0.03 2 2.34E- 04 54.5 LYM22 3 12674. 5 K 0.49 6 6.88E- 01 5.3 LYM13 0 12332. 1 J 0.03 1 2.64E- 04 50.1 LYM21 2 13033. 6 K 0.48 9 7.67E- 01 4 LYM17 4 12411. 3 J 0.03 4 3.59E- 04 63.7 LYM16 5 12972. 6 K 0.49 1 7.69E- 01 4.3 LYM10 5 12293. 1 J 0.03 1 6.37E- 04 49.9 LYM20 3 12663. 2 K 0.48 8 7.77E- 01 3.6 LYM17 4 12412. 1 J 0.03 2 8.23E- 04 51.7 LYM14 2 12804. 4 K 0.48 8.75E- 01 2 LYM10 5 12295. 2 J 0.03 1 1.04E- 03 48 LYM20 7 13252. 2 K 0.47 9 8.90E- 01 1.8 LYM28 9 12493. 1 J 0.03 1.42E- 03 44.8 LYM24 2 13051. 8 K 0.47 9 8.95E- 01 1.7 LYM25 5 13082. 5 J 0.03 2 1.50E- 03 56.1 LYM14 2 12801. 8 K 0.47 9 9.03E- 01 1.7 LYM15 3 12324. 2 J 0.03 1.83E- 03 45.6 LYM27 0 12872. 5 K 0.47 9 9.09E- 01 1.7 LYM10 6 12144. 4 J 0.02 9 1.94E- 03 40.2 LYM21 2 13032. 6 K 0.47 7 9.20E- 01 1.4 LYM10 2 12222. 2 J 0.02 9 2.58E- 03 41.7 LYM20 7 13251. 4 K 0.47 7 9.26E- 01 1.2 LYM28 8 12743. 5 J 0.03 2.77E- 03 46 LYM22 0 12851. 13 K 0.47 7 9.27E- 01 1.2 LYM10 5 12294. 2 J 0.02 9 3.58E- 03 39 LYM14 2 12803. 6 K 0.47 6 9.37E- 01 1.1 LYM17 4 12411. 2 J 0.03 3.72E- 03 44.5 CONTR OL _ K 0.47 1 _ 0 LYM13 7 12151. 1 J 0.02 9 3.78E- 03 38.1 LYM20 3 12662. 3 L 2.45 4 6.01E- 04 67.5 LYM11 9 12462. 1 J 0.03 3.98E- 03 43.3 LYM16 5 12973. 6 L 2.13 8 6.78E- 03 45.9 LYM28 8 12743. 9 J 0.02 9 4.98E- 03 37.8 LYM16 5 12974. 5 L 2.15 1.34E- 02 46.8 LYM15 2 12371. 2 J 0.03 1 5.43E- 03 50.5 LYM14 2 12804. 4 L 1.96 1 3.94E- 02 33.9 LYM13 8 12562. 2 J 0.02 9 5.54E- 03 38.3 LYM16 5 12972. 6 L 1.94 8 5.24E- 02 33 LYM13 7 12151. 2 J 0.02 8 6.64E- 03 36.8 LYM21 2 13034. 9 L 1.86 2 9.49E- 02 27.2 LYM17 3 12981. 6 J 0.02 8 7.33E- 03 34.4 LYM21 2 13034. 8 L 1.90 5 9.76E- 02 30 LYM27 0 12873. 6 J 0.02 8 7.96E- 03 36.4 LYM16 5 12973. 8 L 1.83 2 1.21E- 01 25.1 LYM25 5 13082. 8 J 0.02 8 8.97E- 03 35.1 LYM20 7 13251. 6 L 1.81 9 1.25E- 01 24.2 LYM11 9 12462. 2 J 0.02 9 1.07E- 02 37.4 2016213786 11 Aug 2016 270 Gene name Event I D Mea n P value % incr. vs. cont. Gene name Event I D Mea n P value % incr. vs. cont. LYM20 3 12664. 1 L 1.79 6 1.54E- 01 22.6 LYM25 5 13082. 7 J 0.02 9 1.24E- 02 37.2 LYM21 2 13032. 8 L 1.80 7 1.78E- 01 23.3 LYM21 2 13032. 8 J 0.02 7 1.37E- 02 31.2 LYM24 2 13051. 8 L 1.79 2 1.99E- 01 22.3 LYM15 3 12321. 2 J 0.02 7 1.78E- 02 31.6 LYM24 2 13054. 9 L 1.70 9 3.00E- 01 16.7 LYM10 5 12297. 2 J 0.02 7 1.78E- 02 30.6 LYM20 7 13251. 4 L 1.68 5 3.34E- 01 15 LYM11 1 12252. 2 J 0.02 7 2.00E- 02 31.9 LYM22 0 12851. 7 L 1.65 2 4.23E- 01 12.8 LYM13 0 12334. 1 J 0.02 6 2.61E- 02 26.9 LYM14 2 12802. 9 L 1.61 8 5.12E- 01 10.5 LYM10 6 12144. 3 J 0.02 7 2.82E- 02 30.8 LYM16 5 12973. 5 L 1.59 5 5.81E- 01 8.9 LYM28 9 12493. 2 J 0.02 8 3.23E- 02 34.8 LYM20 7 13251. 5 L 1.58 9 5.87E- 01 8.5 LYM13 7 12153. 1 J 0.02 6 3.50E- 02 26.5 LYM14 2 12804. 3 L 1.58 1 6.12E- 01 7.9 LYM15 2 12373. 1 J 0.02 6 3.60E- 02 26.5 LYM14 2 12801. 8 L 1.56 8 6.52E- 01 7.1 LYM19 7 12821. 6 J 0.02 6 3.74E- 02 25.9 LYM22 0 12851. 11 L 1.56 4 6.64E- 01 6.7 LYM13 0 12332. 2 J 0.02 6 4.55E- 02 27.4 LYM14 2 12804. 1 L 1.55 7.25E- 01 5.8 LYM90 12395. 3 J 0.02 6 4.79E- 02 25.8 LYM20 3 12664. 2 L 1.52 4 7.99E- 01 4.1 LYM28 8 12743. 8 J 0.02 6 5.52E- 02 24.7 LYM22 3 12674. 2 L 1.50 8 8.52E- 01 3 LYM28 7 12771. 6 J 0.02 6 5.89E- 02 23.5 LYM24 2 13053. 7 L 1.49 1 9.09E- 01 1.8 LYM20 1 12833. 7 J 0.02 5 6.60E- 02 22.3 LYM27 0 12871. 7 L 1.47 1 9.76E- 01 0.5 LYM10 2 12222. 3 J 0.02 6 7.07E- 02 22.7 LYM20 3 12663. 2 L 1.46 7 9.91E- 01 0.2 LYM17 3 12981. 5 J 0.02 6 7.84E- 02 23.1 CONTR OL _ L 1.46 5 _ 0 LYM29 1 12754. 9 J 0.02 6 8.08E- 02 26.4 LYM20 3 12662. 3 M 0.30 7 6.02E- 04 65.1 LYM11 1 12254. 4 J 0.02 5 8.41E- 02 22 LYM16 5 12973. 6 M 0.26 7 7.02E- 03 43.8 LYM13 0 12331. 3 J 0.02 7 8.47E- 02 31 LYM16 5 12974. 5 M 0.26 9 1.43E- 02 44.6 LYM15 3 12322. 1 J 0.02 5 1.13E- 01 19.3 LYM14 2 12804. 4 M 0.24 5 4.25E- 02 31.9 LYM10 2 12221. 1 J 0.02 5 1.20E- 01 20 LYM16 5 12972. 6 M 0.24 4 5.69E- 02 31 LYM10 7 12631. 4 J 0.02 5 1.20E- 01 20.2 LYM21 2 13034. 9 M 0.23 3 1.04E- 01 25.3 LYM14 3 12524. 7 J 0.02 6 1.22E- 01 26.9 LYM21 2 13034. 8 M 0.23 8 1.07E- 01 28.1 LYM10 2 12222. 1 J 0.02 5 1.30E- 01 19.7 2016213786 11 Aug 2016 271 Gene name Event I D Mea n P value % incr. vs. cont. Gene name Event I D Mea n P value % incr. vs. cont. LYM16 5 12973. 8 M 0.22 9 1.33E- 01 23.2 LYM18 3 12994. 8 J 0.02 6 1.32E- 01 24.3 LYM20 7 13251. 6 M 0.22 7 1.38E- 01 22.4 LYM10 7 12631. 2 J 0.02 5 1.38E- 01 18.9 LYM20 3 12664. 1 M 0.22 4 1.69E- 01 20.8 LYM28 8 12741. 9 J 0.02 5 1.56E- 01 19.2 LYM21 2 13032. 8 M 0.22 6 1.96E- 01 21.5 LYM21 2 13031. 6 J 0.02 4 1.70E- 01 16.3 LYM24 2 13051. 8 M 0.22 4 2.19E- 01 20.5 LYM13 7 12154. 5 J 0.02 6 1.75E- 01 22.8 LYM24 2 13054. 9 M 0.21 4 3.31E- 01 14.9 LYM28 9 12492. 2 J 0.02 5 1.76E- 01 20.6 LYM20 7 13251. 4 M 0.21 1 3.69E- 01 13.3 LYM15 2 12371. 3 J 0.02 5 1.77E- 01 20.4 LYM22 0 12851. 7 M 0.20 6 4.66E- 01 11.1 LYM13 8 12564. 1 J 0.02 5 1.84E- 01 19 LYM14 2 12802. 9 M 0.20 2 5.62E- 01 8.9 LYM24 2 13051. 8 J 0.02 4 1.87E- 01 17.1 LYM16 5 12973. 5 M 0.19 9 6.37E- 01 7.3 LYM10 5 12294. 3 J 0.02 4 1.91E- 01 16.8 LYM20 7 13251. 5 M 0.19 9 6.45E- 01 6.9 LYM10 6 12141. 4 J 0.02 4 1.95E- 01 16.3 LYM14 2 12804. 3 M 0.19 8 6.72E- 01 6.3 LYM25 5 13082. 9 J 0.02 4 2.05E- 01 16.4 LYM14 2 12801. 8 M 0.19 6 7.14E- 01 5.5 LYM13 0 12333. 1 J 0.02 4 2.15E- 01 16.4 LYM22 0 12851. 11 M 0.19 5 7.28E- 01 5.2 LYM14 2 12802. 9 J 0.02 4 2.26E- 01 17.3 LYM14 2 12804. 1 M 0.19 4 7.89E- 01 4.3 LYM24 2 13052. 5 J 0.02 4 2.31E- 01 14.8 LYM20 3 12664. 2 M 0.19 1 8.68E- 01 2.5 LYM10 7 12631. 1 J 0.02 4 2.35E- 01 15.8 LYM22 3 12674. 2 M 0.18 8 9.25E- 01 1.4 LYM18 3 12993. 5 J 0.02 4 2.40E- 01 15.5 LYM24 2 13053. 7 M 0.18 6 9.85E- 01 0.3 LYM20 1 12834. 6 J 0.02 4 2.60E- 01 13.6 CONTR OL _ M 0.18 6 _ 0 LYM18 3 12993. 7 J 0.02 4 2.63E- 01 15.1 LYM20 3 12662. 3 N 0.26 4 3.40E- 02 25.7 LYM10 6 12142. 3 J 0.02 4 3.01E- 01 13.1 LYM16 5 12973. 6 N 0.25 2 7.08E- 02 19.8 LYM21 2 13034. 9 J 0.02 4 3.25E- 01 17.3 LYM20 7 13251. 6 N 0.23 9 2.15E- 01 13.5 LYM10 7 12632. 1 J 0.02 3 3.27E- 01 13 LYM16 5 12974. 5 N 0.24 5 2.21E- 01 16.6 LYM10 2 12222. 6 J 0.02 3 3.49E- 01 12.4 LYM20 3 12664. 1 N 0.23 6 2.76E- 01 12.4 LYM14 3 12524. 5 J 0.02 4 3.52E- 01 15.7 LYM16 5 12972. 6 N 0.23 8 2.78E- 01 13.2 LYM29 1 12753. 6 J 0.02 3 3.61E- 01 12.4 LYM21 2 13034. 9 N 0.23 5 2.89E- 01 11.8 LYM19 8 13005. 8 J 0.02 3 3.80E- 01 10.4 2016213786 11 Aug 2016 272 Gene name Event I D Mea n P value % incr. vs. cont. Gene name Event I D Mea n P value % incr. vs. cont. LYM21 2 13034. 8 N 0.23 8 2.99E- 01 13.2 LYM28 7 12771. 7 J 0.02 3 4.35E- 01 9.5 LYM14 2 12804. 4 N 0.22 7 4.59E- 01 8 LYM20 1 12833. 9 J 0.02 3 4.54E- 01 9.4 LYM16 5 12973. 8 N 0.22 2 6.03E- 01 5.6 LYM14 2 12804. 3 J 0.02 3 4.60E- 01 11.2 LYM24 2 13053. 7 N 0.22 2 6.06E- 01 5.7 LYM27 0 12871. 7 J 0.02 3 4.62E- 01 9.4 LYM14 2 12804. 1 N 0.22 3 6.06E- 01 5.9 LYM14 2 12801. 8 J 0.02 3 4.62E- 01 9 LYM14 2 12802. 9 N 0.22 6.96E- 01 4.3 LYM28 7 12773. 7 J 0.02 3 4.62E- 01 10.2 LYM24 2 13051. 8 N 0.21 8 7.46E- 01 3.8 LYM28 9 12491. 4 J 0.02 3 4.64E- 01 8.6 LYM27 0 12871. 7 N 0.21 8 7.46E- 01 3.5 LYM17 3 12982. 7 J 0.02 3 4.68E- 01 11.3 LYM16 5 12973. 5 N 0.21 7 7.75E- 01 3.3 LYM20 8 13012. 5 J 0.02 3 4.71E- 01 12.1 LYM22 0 12851. 7 N 0.21 7 7.88E- 01 3.1 LYM44 11885. 4 J 0.02 2 5.57E- 01 7.6 LYM21 2 13032. 8 N 0.21 7 7.96E- 01 3 LYM10 5 12297. 1 J 0.02 2 5.76E- 01 7.3 LYM24 2 13054. 9 N 0.21 3 9.14E- 01 1.2 LYM27 0 12871. 8 J 0.02 2 5.94E- 01 7.6 LYM20 7 13251. 4 N 0.21 3 9.16E- 01 1.1 LYM25 5 13081. 5 J 0.02 2 5.99E- 01 8 LYM20 3 12664. 2 N 0.21 3 9.31E- 01 1 LYM27 0 12871. 5 J 0.02 3 6.13E- 01 9.1 LYM14 2 12804. 3 N 0.21 2 9.52E- 01 0.6 LYM11 1 12251. 1 J 0.02 2 6.31E- 01 5.9 LYM20 3 12663. 2 N 0.21 1 9.76E- 01 0.3 LYM28 9 12491. 1 J 0.02 2 6.50E- 01 5.6 LYM22 0 12851. 11 N 0.21 1 9.90E- 01 0.1 LYM24 2 13053. 7 J 0.02 2 6.73E- 01 5.4 CONTR OL _ N 0.21 _ 0 LYM18 3 12994. 7 J 0.02 2 7.41E- 01 4.1 LYM16 5 12973. 6 O 2.12 1.10E-03 43.2 LYM27 0 12872. 7 J 0.02 2 7.82E- 01 3.7 LYM16 5 12973. 8 O 1.84 7 4.09E- 03 24.8 LYM19 7 12824. 4 J 0.02 1 7.94E- 01 3.2 LYM20 7 13251. 6 o 1.79 1 3.64E- 02 20.9 LYM28 7 12774. 6 J 0.02 2 7.96E- 01 3.5 LYM14 2 12804. 4 o 1.94 9 4.00E- 02 31.6 LYM17 3 12982. 6 J 0.02 1 8.19E- 01 2.9 LYM20 3 12664. 1 o 1.76 1 6.02E- 02 18.9 LYM20 8 13013. 6 J 0.02 1 8.22E- 01 3 LYM21 2 13034. 9 o 1.87 4 1.12E- 01 26.6 LYM10 0 12131. 3 J 0.02 1 8.23E- 01 2.8 LYM20 3 12662. 3 o 2.41 6 1.58E- 01 63.2 LYM14 3 12521. 2 J 0.02 1 8.76E- 01 2 LYM16 5 12972. 6 o 1.95 2 2.19E- 01 31.8 LYM14 3 12523. 4 J 0.02 1 8.78E- 01 2.7 2016213786 11 Aug 2016 273 Gene name Event I D Mea n P value % incr. vs. cont. Gene name Event I D Mea n P value % incr. vs. cont. LYM20 7 13251. 5 O 1.59 2.62E- 01 7.4 LYM21 2 13034. 8 J 0.02 1 8.79E- 01 1.9 LYM22 0 12851. 7 o 1.62 7 2.95E- 01 9.9 LYM19 8 13004. 6 J 0.02 1 8.86E- 01 1.7 LYM20 7 13251. 4 o 1.65 3 3.18E- 01 11.6 LYM14 3 12521. 1 J 0.02 1 9.11E- 01 1.3 LYM16 5 12974. 5 o 2.14 2 3.19E- 01 44.7 LYM29 1 12751. 2 J 0.02 1 9.32E- 01 1 LYM22 0 12851. 11 o 1.56 7 3.79E- 01 5.8 LYM10 0 12133. 3 J 0.02 1 9.61E- 01 0.6 LYM21 2 13034. 8 o 1.89 6 4.48E- 01 28.1 LYM15 2 12372. 2 J 0.02 1 9.80E- 01 0.3 LYM21 2 13032. 8 o 1.81 3 4.49E- 01 22.4 LYM20 8 13012. 8 J 0.02 1 9.84E- 01 0.3 LYM14 2 12801. 8 o 1.60 4 5.02E- 01 8.3 CONTR OL _ J 0.02 1 _ 0 LYM24 2 13054. 9 o 1.68 8 5.03E- 01 14 LYM28 8 12741. 9 K 0.71 3 2.72E- 01 13.6 LYM14 2 12802. 9 o 1.60 4 5.24E- 01 8.3 LYM11 9 12462. 2 K 0.70 6 3.08E- 01 12.4 LYM24 2 13051. 8 o 1.80 2 5.42E- 01 21.7 LYM28 9 12493. 1 K 0.70 4 3.13E- 01 12.1 LYM14 2 12804. 3 o 1.56 1 6.15E- 01 5.4 LYM14 2 12804. 1 K 0.69 5 3.86E- 01 10.7 LYM16 5 12973. 5 o 1.57 8 6.95E- 01 6.6 LYM44 11882. 1 K 0.69 5 3.88E- 01 10.7 LYM22 3 12674. 2 o 1.49 6 8.67E- 01 1 LYM14 3 12524. 7 K 0.68 8 4.41E- 01 9.5 LYM14 2 12804. 1 o 1.54 1 8.75E- 01 4.1 LYM61 13174. 7 K 0.69 5 4.79E- 01 10.7 LYM20 3 12664. 2 o 1.51 9.11E- 01 2 LYM11 9 12461. 4 K 0.67 6 5.05E- 01 7.6 CONTR OL _ o 1.48 1 _ 0 LYM13 7 12154. 5 K 0.67 5 5.37E- 01 7.5 LYM16 5 12973. 6 P 2.64 3 2.53E- 03 17.9 LYM61 13174. 5 K 0.67 5 5.82E- 01 7.5 LYM20 7 13251. 6 P 2.52 5 1.43E- 02 12.6 LYM18 3 12994. 7 K 0.66 5 6.12E- 01 5.9 LYM16 5 12973. 8 P 2.47 2 3.44E- 02 10.2 LYM10 2 12222. 3 K 0.66 3 6.21E- 01 5.6 LYM20 3 12662. 3 P 2.9 8.02E- 02 29.3 LYM17 4 12414. 3 K 0.66 3 6.23E- 01 5.6 LYM14 2 12804. 4 P 2.42 1.34E- 01 7.9 LYM22 0 12851. 8 K 0.65 7 6.76E- 01 4.7 LYM20 7 13251. 4 P 2.38 9 1.67E- 01 6.5 LYM25 5 13082. 7 K 0.65 7 6.95E- 01 4.7 LYM20 3 12664. 1 P 2.47 8 3.11E- 01 10.5 LYM28 9 12493. 2 K 0.65 3 7.43E- 01 4 LYM21 2 13034. 9 P 2.45 3.23E- 01 9.2 LYM19 8 13005. 8 K 0.65 7.67E- 01 3.5 LYM16 5 12972. 6 P 2.55 8 3.80E- 01 14.1 LYM11 1 12252. 2 K 0.64 9 7.68E- 01 3.3 2016213786 11 Aug 2016 274 Gene name Event I D Mea n P value % incr. vs. cont. Gene name Event I D Mea n P value % incr. vs. cont. LYM27 0 12871. 7 P 2.31 4 4.47E- 01 3.2 LYM90 12395. 1 K 0.65 7.75E- 01 3.5 LYM21 2 13032. 8 P 2.37 4.77E- 01 5.7 LYM24 2 13052. 5 K 0.64 9 7.83E- 01 3.3 LYM16 5 12974. 5 P 2.60 7 4.77E- 01 16.2 LYM28 9 12491. 1 K 0.64 7 7.89E- 01 3 LYM24 2 13051. 8 P 2.42 2 4.96E- 01 8 LYM15 3 12322. 1 K 0.64 5 8.11E- 01 2.7 LYM21 2 13034. 8 P 2.57 5.11E- 01 14.6 LYM10 5 12297. 2 K 0.64 4 8.23E- 01 2.7 LYM24 2 13054. 9 P 2.35 8 6.45E- 01 5.1 LYM44 11885. 3 K 0.64 3 8.28E- 01 2.5 LYM14 2 12802. 9 P 2.28 6 6.67E- 01 1.9 LYM10 2 12222. 6 K 0.64 3 8.39E- 01 2.5 LYM16 5 12973. 5 P 2.31 5 7.84E- 01 3.2 LYM28 8 12744. 7 K 0.64 3 8.42E- 01 2.5 LYM20 3 12664. 2 P 2.28 8.53E- 01 1.7 LYM29 1 12754. 9 K 0.64 3 8.48E- 01 2.5 LYM14 2 12804. 1 P 2.27 6 8.85E- 01 1.5 LYM10 7 12631. 4 K 0.64 1 8.56E- 01 2.1 LYM22 0 12851. 7 P 2.26 9.04E- 01 0.8 LYM29 1 12751. 7 K 0.64 8.64E- 01 2 LYM27 0 12872. 7 P 2.25 9.41E- 01 0.3 LYM28 8 12743. 9 K 0.64 8.66E- 01 2 LYM14 2 12804. 3 P 2.24 5 9.83E- 01 0.1 LYM17 4 12414. 2 K 0.64 8.72E- 01 2 CONTR OL _ P 2.24 3 _ 0 LYM90 12392. 1 K 0.64 8.76E- 01 1.9 LYM4 11701. 1 A 93.6 53 1.73E- 03 4 LYM14 3 12523. 4 K 0.64 1 8.77E- 01 2.1 LYM21 11672. 4 A 93.5 89 1.90E- 03 3.9 LYM11 1 12251. 3 K 0.63 9 8.79E- 01 1.8 LYM16 2 12231. 3 A 93.4 2.63E- 03 3.7 LYM10 2 12221. 1 K 0.63 6 9.12E- 01 1.3 LYM1 11602. 6 A 93.3 52 2.88E- 03 3.7 LYM10 2 12221. 2 K 0.63 3 9.47E- 01 0.8 LYM4 11702. 3 A 93.2 89 3.25E- 03 3.6 LYM17 4 12412. 1 K 0.63 1 9.60E- 01 0.6 LYM12 9 12571. 3 A 93.2 81 3.37E- 03 3.6 LYM25 5 13082. 8 K 0.63 9.70E- 01 0.4 LYM2 11692. 3 A 93.1 97 3.86E- 03 3.5 LYM13 7 12152. 1 K 0.62 9 9.82E- 01 0.3 LYM2 11695. 3 A 93.1 69 4.02E- 03 3.5 LYM44 11884. 1 K 0.62 8 9.94E- 01 0.1 LYM17 4 12411. 2 A 93.1 89 4.79E- 03 3.5 CONTR OL _ K 0.62 8 _ 0 LYM12 9 12573. 5 A 93.2 64 5.07E- 03 3.6 LYM13 8 12561. 1 L 2.7 0.00E +00 124.8 LYM9 11632. 2 A 92.9 63 5.75E- 03 3.2 LYM17 4 12414. 3 L 2.07 5 1.50E- 05 72.8 LYM9 11634. 5 A 92.7 88 8.06E- 03 3 LYM13 8 12561. 3 L 2.06 2 2.00E- 05 71.7 2016213786 11 Aug 2016 275 Gene name Event I D Mea n P value % incr. vs. cont. Gene name Event I D Mea n P value % incr. vs. cont. LYM1 11602. 1 A 92.6 34 1.1 OE-02 2.9 LYM11 9 12461. 4 L 2.01 6 4.40E- 05 67.8 LYM17 11684. 5 A 92.5 39 1.23E- 02 2.8 LYM11 9 12461. 1 L 1.97 8 1.02E- 04 64.7 LYM11 1 12251. 3 A 92.4 4 1.48E- 02 2.6 LYM13 0 12332. 1 L 1.89 5 1.67E- 04 57.8 LYM16 2 12234. 4 A 92.5 26 1.48E- 02 2.7 LYM10 6 12142. 2 L 1.96 9 3.33E- 04 63.9 LYM4 11706. 5 A 92.4 04 1.58E- 02 2.6 LYM11 9 12463. 2 L 1.88 4 4.03E- 04 56.8 LYM13 0 12333. 1 A 92.7 28 1.74E- 02 3 LYM22 0 12851. 8 L 1.88 5.61E- 04 56.5 LYM14 3 12521. 1 A 92.3 55 1.77E- 02 2.5 LYM17 4 12411. 3 L 1.93 1 8.78E- 04 60.7 LYM28 9 12491. 4 A 92.2 93 1.95E- 02 2.5 LYM17 4 12412. 1 L 1.83 1 1.48E- 03 52.4 LYM14 3 12523. 4 A 92.2 43 2.22E- 02 2.4 LYM28 9 12493. 1 L 1.80 5 1.50E- 03 50.2 LYM13 0 12331. 3 A 92.6 7 2.48E- 02 2.9 LYM10 7 12632. 3 L 1.79 9 2.47E- 03 49.7 LYM4 11706. 3 A 92.1 34 2.66E- 02 2.3 LYM15 3 12323. 2 L 1.78 1 2.51E- 03 48.2 LYM29 0 12502. 1 A 93.9 71 2.67E- 02 4.3 LYM15 3 12324. 1 L 1.79 8 2.61E- 03 49.7 LYM17 11683. 1 A 93.1 89 2.71E- 02 3.5 LYM11 9 12462. 1 L 1.78 5.10E- 03 48.1 LYM17 11681. 4 A 92.3 82 2.78E- 02 2.6 LYM28 8 12743. 9 L 1.70 4 5.72E- 03 41.9 LYM13 2 12275. 1 A 92.0 86 2.93E- 02 2.2 LYM25 5 13082. 5 L 1.82 6 5.79E- 03 52 LYM26 8 12482. 3 A 92.7 99 3.40E- 02 3 LYM25 5 13082. 8 L 1.68 7 7.22E- 03 40.4 LYM14 3 12524. 7 A 92.0 03 3.43E- 02 2.2 LYM28 8 12743. 5 L 1.74 5 8.60E- 03 45.3 LYM16 11623. 5 A 91.9 94 3.52E- 02 2.1 LYM25 5 13082. 7 L 1.71 9 1.08E- 02 43.1 LYM10 0 12131. 3 A 93.2 35 3.92E- 02 3.5 LYM15 3 12324. 2 L 1.66 1 1.28E- 02 38.3 LYM14 1 12404. 3 A 92.2 79 3.95E- 02 2.5 LYM11 9 12462. 2 L 1.70 5 1.33E- 02 42 LYM9 11633. 7 A 91.9 68 4.61E- 02 2.1 LYM10 2 12222. 2 L 1.64 2 1.38E- 02 36.7 LYM16 11623. 2 A 91.9 48 4.62E- 02 2.1 LYM15 2 12371. 2 L 1.73 2 1.45E- 02 44.2 LYM11 3 12441. 4 A 91.8 32 4.82E- 02 2 LYM10 5 12293. 1 L 1.64 8 1.48E- 02 37.1 LYM16 11622. 2 A 91.7 95 5.19E- 02 1.9 LYM13 7 12151. 4 L 1.62 5 1.60E- 02 35.3 LYM28 9 12491. 1 A 92.5 54 5.47E- 02 2.8 LYM17 4 12411. 2 L 1.65 1 1.70E- 02 37.4 LYM17 4 12414. 2 A 91.8 86 5.60E- 02 2 LYM28 9 12493. 2 L 1.71 5 1.88E- 02 42.8 2016213786 11 Aug 2016 276 Gene name Event I D Mea n P value % incr. vs. cont. Gene name Event I D Mea n P value % incr. vs. cont. LYM15 11612. 3 A 92.3 6.55E- 02 2.5 LYM10 6 12144. 4 L 1.58 8 2.45E- 02 32.2 LYM14 3 12521. 2 A 92.3 39 6.73E- 02 2.5 LYM10 5 12295. 2 L 1.59 4 2.68E- 02 32.7 LYM22 11762. 2 A 92.0 49 7.65E- 02 2.2 LYM10 5 12297. 2 L 1.59 1 2.80E- 02 32.4 LYM14 8 12173. 1 A 93.6 23 7.77E- 02 4 LYM13 0 12332. 2 L 1.58 5 2.81E- 02 31.9 LYM26 8 12483. 4 A 92.1 1 7.91E- 02 2.3 LYM13 0 12334. 1 L 1.57 2.87E- 02 30.7 LYM15 3 12323. 2 A 92.0 18 8.66E- 02 2.2 LYM27 0 12873. 6 L 1.55 8 4.30E- 02 29.7 LYM12 9 12572. 4 A 95.4 26 8.79E- 02 6 LYM11 1 12252. 2 L 1.56 4.53E- 02 29.8 LYM15 2 12373. 1 A 92.9 94 9.17E- 02 3.3 LYM15 3 12321. 2 L 1.56 6 4.59E- 02 30.4 LYM16 11624. 6 A 91.6 07 9.39E- 02 1.7 LYM13 7 12151. 1 L 1.54 8 4.97E- 02 28.8 LYM11 1 12251. 1 A 91.5 31 9.51E- 02 1.6 LYM13 7 12151. 2 L 1.54 3 6.15E- 02 28.5 LYM10 2 12222. 3 A 91.6 11 1.04E- 01 1.7 LYM10 5 12294. 2 L 1.50 2 7.39E- 02 25.1 LYM15 2 12371. 3 A 91.4 65 1.08E- 01 1.6 LYM10 6 12144. 3 L 1.53 1 7.99E- 02 27.4 LYM10 5 12293. 1 A 92.8 55 1.1 OE-01 3.1 LYM13 8 12562. 2 L 1.51 8.00E- 02 25.7 LYM14 8 12171. 2 A 97.1 89 1.13E- 01 7.9 LYM29 1 12754. 9 L 1.52 4 8.85E- 02 26.8 LYM3 12041. 2 A 91.8 2 1.20E- 01 2 LYM13 0 12331. 3 L 1.58 4 9.07E- 02 31.9 LYM29 0 12502. 4 A 92.5 41 1.25E- 01 2.8 LYM13 7 12154. 5 L 1.53 5 1.33E- 01 27.8 LYM22 11762. 1 A 91.5 81 1.28E- 01 1.7 LYM14 3 12524. 7 L 1.50 4 1.44E- 01 25.2 LYM26 8 12482. 1 A 91.5 18 1.36E- 01 1.6 LYM28 9 12492. 2 L 1.44 2 1.47E- 01 20.1 LYM3 12043. 1 A 92.1 54 1.37E- 01 2.3 LYM10 2 12222. 3 L 1.44 1.55E- 01 19.8 LYM11 1 12252. 2 A 92.0 17 1.44E- 01 2.2 LYM28 8 12741. 9 L 1.45 1 1.68E- 01 20.8 LYM13 8 12561. 3 A 91.7 41 1.49E- 01 1.9 LYM17 3 12981. 6 L 1.42 7 1.71E- 01 18.8 LYM14 8 12172. 1 A 91.8 54 1.50E- 01 2 LYM13 7 12153. 1 L 1.42 7 1.79E- 01 18.8 LYM15 11611. 3 A 91.2 82 1.57E- 01 1.4 LYM13 8 12564. 1 L 1.43 2 1.94E- 01 19.2 LYM13 4 12313. 2 A 92.9 27 1.58E- 01 3.2 LYM90 12395. 3 L 1.42 5 1.97E- 01 18.6 LYM14 1 12404. 2 A 92.6 66 1.60E- 01 2.9 LYM15 2 12371. 3 L 1.43 9 2.02E- 01 19.8 LYM15 11612. 2 A 92.3 99 1.67E- 01 2.6 LYM21 2 13032. 8 L 1.40 9 2.12E- 01 17.3 2016213786 11 Aug 2016 277 Gene name Event I D Mea n P value % incr. vs. cont. Gene name Event I D Mea n P value % incr. vs. cont. LYM13 8 12561. 1 A 91.6 67 1.72E- 01 1.8 LYM28 8 12743. 8 L 1.41 2.21E- 01 17.4 LYM10 11741. 2 A 93.0 84 1.84E- 01 3.4 LYM11 1 12254. 4 L 1.39 6 2.43E- 01 16.2 LYM2 11693. 3 A 91.3 11 1.94E- 01 1.4 LYM19 7 12821. 6 L 1.38 3 2.76E- 01 15.1 LYM13 11772. 1 A 91.1 62 1.96E- 01 1.2 LYM24 2 13051. 8 L 1.37 6 3.06E- 01 14.6 LYM15 2 12371. 2 A 94.0 35 1.98E- 01 4.4 LYM10 7 12631. 4 L 1.36 7 3.11E- 01 13.8 LYM14 1 12404. 4 A 91.3 82 2.00E- 01 1.5 LYM24 2 13052. 5 L 1.37 1 3.18E- 01 14.1 LYM26 8 12483. 2 A 91.0 85 2.10E- 01 1.1 LYM15 3 12322. 1 L 1.35 6 3.52E- 01 12.8 LYM29 0 12502. 2 A 91.2 45 2.10E- 01 1.3 LYM10 6 12141. 4 L 1.35 5 3.53E- 01 12.8 LYM13 2 12276. 1 A 91.9 05 2.21E- 01 2 LYM15 2 12373. 1 L 1.35 4 3.59E- 01 12.7 LYM13 0 12332. 1 A 91.4 23 2.26E- 01 1.5 LYM10 7 12631. 2 L 1.35 6 3.69E- 01 12.9 LYM13 7 12154. 5 A 92.6 34 2.36E- 01 2.9 LYM10 7 12631. 1 L 1.35 4 3.80E- 01 12.7 LYM14 1 12402. 4 A 92.7 47 2.36E- 01 3 LYM10 2 12221. 1 L 1.35 1 3.82E- 01 12.4 LYM13 11771. 6 A 92.6 02 2.48E- 01 2.8 LYM18 3 12994. 8 L 1.38 5 3.83E- 01 15.3 LYM15 11614. 3 A 90.9 56 2.69E- 01 1 LYM10 5 12294. 3 L 1.32 1 4.64E- 01 10 LYM22 11764. 7 A 92.1 54 2.90E- 01 2.3 LYM17 3 12981. 5 L 1.32 4.93E- 01 9.9 LYM13 2 12273. 2 A 91.6 78 2.99E- 01 1.8 LYM28 9 12491. 4 L 1.31 2 5.04E- 01 9.2 LYM11 9 12462. 1 A 92.8 84 2.99E- 01 3.1 LYM10 2 12222. 1 L 1.31 5.15E- 01 9.1 LYM9 11633. 2 A 92.3 7 3.05E- 01 2.6 LYM25 5 13082. 9 L 1.31 4 5.16E- 01 9.4 LYM1 11603. 2 A 91.1 05 3.08E- 01 1.2 LYM14 3 12524. 5 L 1.33 5 5.26E- 01 11.1 LYM17 11682. 1 A 91.5 75 3.09E- 01 1.7 LYM28 9 12491. 1 L 1.30 5 5.32E- 01 8.6 LYM19 11751. 5 A 91.9 71 3.18E- 01 2.1 LYM14 2 12802. 9 L 1.31 6 5.37E- 01 9.5 LYM10 11744. 1 A 90.9 73 3.22E- 01 1 LYM10 0 12131. 3 L 1.3 5.51E- 01 8.2 LYM11 9 12463. 2 A 91.6 19 3.27E- 01 1.7 LYM10 2 12222. 6 L 1.30 3 5.63E- 01 8.5 LYM16 11624. 4 A 91.3 28 3.34E- 01 1.4 LYM28 7 12774. 6 L 1.28 2 6.30E- 01 6.7 LYM14 1 12404. 1 A 90.8 94 3.38E- 01 0.9 LYM13 0 12333. 1 L 1.27 4 6.78E- 01 6 LYM19 11751. 4 A 92.3 74 3.42E- 01 2.6 LYM19 8 13005. 8 L 1.26 6 6.94E- 01 5.4 2016213786 11 Aug 2016 278 Gene name Event I D Mea n P value % incr. vs. cont. Gene name Event I D Mea n P value % incr. vs. cont. LYM17 11684. 4 A 91.3 21 3.42E- 01 1.4 LYM18 3 12993. 7 L 1.27 7.00E- 01 5.7 LYM17 4 12411. 3 A 90.9 96 3.43E- 01 1 LYM10 6 12142. 3 L 1.26 5 7.00E- 01 5.3 LYM10 5 12297. 1 A 92.5 11 3.51E- 01 2.7 LYM18 3 12994. 7 L 1.26 4 7.06E- 01 5.3 LYM15 2 12372. 2 A 91.6 33 3.54E- 01 1.7 LYM20 1 12834. 6 L 1.26 1 7.14E- 01 5 LYM15 3 12324. 2 A 90.8 81 3.57E- 01 0.9 LYM29 1 12753. 6 L 1.26 3 7.29E- 01 5.1 LYM28 9 12493. 6 A 90.7 91 3.59E- 01 0.8 LYM28 7 12771. 6 L 1.25 8 7.30E- 01 4.7 LYM13 0 12332. 2 A 92.2 23 3.66E- 01 2.4 LYM28 7 12773. 7 L 1.26 3 7.39E- 01 5.1 LYM10 11744. 5 A 93.0 31 3.89E- 01 3.3 LYM21 2 13031. 6 L 1.25 5 7.40E- 01 4.4 LYM14 3 12524. 2 A 90.7 7 4.06E- 01 0.8 LYM44 11885. 4 L 1.25 4 7.56E- 01 4.4 LYM10 6 12141. 4 A 90.7 74 4.06E- 01 0.8 LYM21 2 13034. 9 L 1.26 7 7.63E- 01 5.5 LYM21 11671. 2 A 91.5 32 4.18E- 01 1.6 LYM17 3 12982. 6 L 1.23 8.61E- 01 2.4 LYM29 0 12504. 1 A 91.0 68 4.24E- 01 1.1 LYM20 1 12833. 7 L 1.22 7 8.72E- 01 2.2 LYM11 1 12254. 4 A 91.0 31 4.40E- 01 1.1 LYM44 11882. 1 L 1.20 9 9.64E- 01 0.7 LYM11 9 12461. 4 A 91.1 97 4.58E- 01 1.3 LYM20 8 13012. 5 L 1.20 6 9.83E- 01 0.4 LYM21 11673. 1 A 91.3 87 4.60E- 01 1.5 CONTR OL _ L 1.20 1 _ 0 LYM14 0 12262. 3 A 91.3 89 4.61E- 01 1.5 LYM13 8 12561. 1 M 0.33 8 0.00E +00 124.8 LYM14 8 12174. 2 A 91.6 62 4.77E- 01 1.8 LYM17 4 12414. 3 M 0.25 9 1.50E- 05 72.8 LYM11 1 12254. 3 A 91.1 61 4.82E- 01 1.2 LYM13 8 12561. 3 M 0.25 8 2.00E- 05 71.7 LYM13 8 12564. 1 A 91.5 67 4.91E- 01 1.7 LYM11 9 12461. 4 M 0.25 2 4.40E- 05 67.8 LYM19 11754. 1 A 90.5 86 5.02E- 01 0.6 LYM11 9 12461. 1 M 0.24 7 1.02E- 04 64.7 LYM11 9 12462. 2 A 91.2 66 5.04E- 01 1.3 LYM13 0 12332. 1 M 0.23 7 1.67E- 04 57.8 LYM10 2 12222. 2 A 91.3 56 5.05E- 01 1.4 LYM10 6 12142. 2 M 0.24 6 3.33E- 04 63.9 LYM10 5 12297. 2 A 90.8 82 5.68E- 01 0.9 LYM11 9 12463. 2 M 0.23 5 4.03E- 04 56.8 LYM11 9 12461. 1 A 91.2 25 5.83E- 01 1.3 LYM22 0 12851. 8 M 0.23 5 5.61E- 04 56.5 LYM22 11764. 1 A 91.3 11 5.88E- 01 1.4 LYM17 4 12411. 3 M 0.24 1 8.78E- 04 60.7 LYM22 11761. 3 A 90.6 21 6.14E- 01 0.6 LYM17 4 12412. 1 M 0.22 9 1.48E- 03 52.4 2016213786 11 Aug 2016 279 Gene name Event I D Mea n P value % incr. vs. cont. Gene name Event I D Mea n P value % incr. vs. cont. LYM11 3 12442. 1 A 90.8 93 6.16E- 01 0.9 LYM28 9 12493. 1 M 0.22 6 1.50E- 03 50.2 LYM13 4 12311. 2 A 90.8 68 6.23E- 01 0.9 LYM10 7 12632. 3 M 0.22 5 2.47E- 03 49.7 LYM12 9 12573. 3 A 91.7 22 6.45E- 01 1.8 LYM15 3 12323. 2 M 0.22 3 2.51E- 03 48.2 LYM17 4 12414. 3 A 90.6 25 6.59E- 01 0.6 LYM15 3 12324. 1 M 0.22 5 2.61E- 03 49.7 LYM10 11742. 1 A 90.4 22 6.74E- 01 0.4 LYM11 9 12462. 1 M 0.22 2 5.10E- 03 48.1 LYM1 11601. 1 A 90.9 06 6.83E- 01 0.9 LYM28 8 12743. 9 M 0.21 3 5.72E- 03 41.9 LYM29 0 12501. 3 A 90.3 9 6.87E- 01 0.4 LYM25 5 13082. 5 M 0.22 8 5.79E- 03 52 LYM14 0 12261. 2 A 91.2 22 6.93E- 01 1.3 LYM25 5 13082. 8 M 0.21 1 7.22E- 03 40.4 LYM3 12041. 1 A 91.5 83 6.94E- 01 1.7 LYM28 8 12743. 5 M 0.21 8 8.60E- 03 45.3 LYM15 3 12321. 2 A 90.6 16 7.11E- 01 0.6 LYM25 5 13082. 7 M 0.21 5 1.08E- 02 43.1 LYM14 8 12174. 1 A 90.5 92 7.15E- 01 0.6 LYM15 3 12324. 2 M 0.20 8 1.28E- 02 38.3 LYM10 2 12221. 1 A 90.4 66 7.40E- 01 0.4 LYM11 9 12462. 2 M 0.21 3 1.33E- 02 42 LYM14 0 12261. 4 A 90.8 37 7.42E- 01 0.9 LYM10 2 12222. 2 M 0.20 5 1.38E- 02 36.7 LYM16 2 12234. 3 A 90.9 09 7.49E- 01 0.9 LYM15 2 12371. 2 M 0.21 7 1.45E- 02 44.2 LYM13 2 12271. 4 A 90.2 98 7.84E- 01 0.3 LYM10 5 12293. 1 M 0.20 6 1.48E- 02 37.1 LYM12 9 12572. 2 A 90.9 07 7.96E- 01 0.9 LYM13 7 12151. 4 M 0.20 3 1.60E- 02 35.3 LYM10 0 12134. 1 A 90.8 09 8.05E- 01 0.8 LYM17 4 12411. 2 M 0.20 6 1.70E- 02 37.4 LYM19 11753. 1 A 90.3 1 8.11E- 01 0.3 LYM28 9 12493. 2 M 0.21 4 1.88E- 02 42.8 LYM28 9 12493. 2 A 90.5 91 8.24E- 01 0.6 LYM10 6 12144. 4 M 0.19 9 2.45E- 02 32.2 LYM10 2 12222. 6 A 90.7 69 8.26E- 01 0.8 LYM10 5 12295. 2 M 0.19 9 2.68E- 02 32.7 LYM10 11742. 2 A 90.5 07 8.27E- 01 0.5 LYM10 5 12297. 2 M 0.19 9 2.80E- 02 32.4 LYM9 11632. 1 A 90.2 31 8.32E- 01 0.2 LYM13 0 12332. 2 M 0.19 8 2.81E- 02 31.9 LYM11 3 12444. 5 A 90.2 43 8.32E- 01 0.2 LYM13 0 12334. 1 M 0.19 6 2.87E- 02 30.7 LYM10 2 12222. 1 A 90.9 68 8.39E- 01 1 LYM27 0 12873. 6 M 0.19 5 4.30E- 02 29.7 LYM1 11604. 4 A 90.5 74 8.76E- 01 0.6 LYM11 1 12252. 2 M 0.19 5 4.53E- 02 29.8 LYM3 12043. 2 A 90.7 01 8.80E- 01 0.7 LYM15 3 12321. 2 M 0.19 6 4.59E- 02 30.4 2016213786 11 Aug 2016 280 Gene name Event I D Mea n P value % incr. vs. cont. Gene name Event I D Mea n P value % incr. vs. cont. LYM10 5 12294. 3 A 90.2 28 8.91E- 01 0.2 LYM13 7 12151. 1 M 0.19 3 4.97E- 02 28.8 LYM15 3 12324. 1 A 90.3 08 8.94E- 01 0.3 LYM13 7 12151. 2 M 0.19 3 6.15E- 02 28.5 LYM15 11614. 4 A 90.1 58 9.00E- 01 0.1 LYM10 5 12294. 2 M 0.18 8 7.39E- 02 25.1 LYM13 11772. 2 A 90.2 6 9.44E- 01 0.2 LYM10 6 12144. 3 M 0.19 1 7.99E- 02 27.4 LYM28 9 12492. 2 A 90.2 34 9.48E- 01 0.2 LYM13 8 12562. 2 M 0.18 9 8.00E- 02 25.7 LYM16 2 12231. 1 A 90.1 45 9.78E- 01 0.1 LYM29 1 12754. 9 M 0.19 8.85E- 02 26.8 CONTR OL _ A 90.0 61 _ 0 LYM13 0 12331. 3 M 0.19 8 9.07E- 02 31.9 LYM13 11771. 6 B 0.27 2 1.17E- 02 23.1 LYM10 7 12631. 4 M 0.18 2 1.23E- 01 21.4 LYM12 9 12573. 3 B 0.28 8 2.16E- 02 30.2 LYM13 7 12154. 5 M 0.19 2 1.33E- 01 27.8 LYM12 9 12573. 5 B 0.36 4 2.30E- 02 65 LYM15 3 12322. 1 M 0.18 1 1.40E- 01 20.6 LYM4 11702. 3 B 0.27 3.35E- 02 22.3 LYM14 3 12524. 7 M 0.18 8 1.44E- 01 25.2 LYM4 11701. 1 B 0.25 9 4.26E- 02 17.5 LYM28 9 12492. 2 M 0.18 1.47E- 01 20.1 LYM15 2 12373. 2 B 0.37 6 4.78E- 02 70.4 LYM10 2 12222. 3 M 0.18 1.55E- 01 19.8 LYM19 11752. 2 B 0.25 5 5.74E- 02 15.5 LYM28 8 12741. 9 M 0.18 1 1.68E- 01 20.8 LYM15 11611. 3 B 0.25 5 6.26E- 02 15.5 LYM17 3 12981. 6 M 0.17 8 1.71E- 01 18.8 LYM13 8 12561. 1 B 0.26 1 6.50E- 02 18.3 LYM13 7 12153. 1 M 0.17 8 1.79E- 01 18.8 LYM17 11682. 1 B 0.32 4 6.56E- 02 46.9 LYM13 8 12564. 1 M 0.17 9 1.94E- 01 19.2 LYM17 11683. 1 B 0.26 6 6.67E- 02 20.3 LYM90 12395. 3 M 0.17 8 1.97E- 01 18.6 LYM13 0 12333. 1 B 0.25 4 7.69E- 02 15.2 LYM15 2 12371. 3 M 0.18 2.02E- 01 19.8 LYM9 11633. 7 B 0.30 1 9.51E- 02 36.4 LYM21 2 13032. 8 M 0.17 6 2.12E- 01 17.3 LYM14 8 12171. 2 B 0.28 1 1.01E- 01 27.4 LYM28 8 12743. 8 M 0.17 6 2.21E- 01 17.4 LYM4 11706. 3 B 0.31 6 1.05E- 01 43.2 LYM11 1 12254. 4 M 0.17 5 2.43E- 01 16.2 LYM4 11705. 2 B 0.31 6 1.25E- 01 43.1 LYM19 7 12821. 6 M 0.17 3 2.76E- 01 15.1 LYM9 11632. 2 B 0.33 9 1.56E- 01 53.4 LYM24 2 13051. 8 M 0.17 2 3.06E- 01 14.6 LYM2 11691. 2 B 0.24 4 1.73E- 01 10.4 LYM24 2 13052. 5 M 0.17 1 3.18E- 01 14.1 LYM16 2 12234. 4 B 0.29 9 2.06E- 01 35.3 LYM10 6 12141. 4 M 0.16 9 3.53E- 01 12.8 2016213786 11 Aug 2016 281 Gene name Event I D Mea n P value % incr. vs. cont. Gene name Event I D Mea n P value % incr. vs. cont. LYM14 8 12174. 1 B 0.31 5 2.13E- 01 42.7 LYM15 2 12373. 1 M 0.16 9 3.59E- 01 12.7 LYM28 9 12493. 2 B 0.27 1 2.20E- 01 22.9 LYM10 7 12631. 2 M 0.16 9 3.69E- 01 12.9 LYM9 11634. 5 B 0.26 2.39E- 01 17.8 LYM10 7 12631. 1 M 0.16 9 3.80E- 01 12.7 LYM12 9 12571. 3 B 0.24 9 2.41E- 01 12.7 LYM10 2 12221. 1 M 0.16 9 3.82E- 01 12.4 LYM15 3 12323. 2 B 0.25 9 2.51E- 01 17.2 LYM18 3 12994. 8 M 0.17 3 3.83E- 01 15.3 LYM11 9 12463. 2 B 0.43 3 2.58E- 01 95.9 LYM10 5 12294. 3 M 0.16 5 4.64E- 01 10 LYM13 0 12331. 3 B 0.23 9 2.71E- 01 8.1 LYM17 3 12981. 5 M 0.16 5 4.93E- 01 9.9 LYM19 11751. 5 B 0.24 3 2.73E- 01 9.8 LYM28 9 12491. 4 M 0.16 4 5.04E- 01 9.2 LYM15 11612. 3 B 0.28 9 2.83E- 01 31.1 LYM10 2 12222. 1 M 0.16 4 5.15E- 01 9.1 LYM21 11672. 4 B 0.25 2 2.88E- 01 14.1 LYM25 5 13082. 9 M 0.16 4 5.16E- 01 9.4 LYM16 11624. 4 B 0.25 1 3.28E- 01 13.5 LYM14 3 12524. 5 M 0.16 7 5.26E- 01 11.1 LYM12 9 12572. 4 B 0.31 6 3.30E- 01 43 LYM28 9 12491. 1 M 0.16 3 5.32E- 01 8.6 LYM11 3 12442. 1 B 0.32 6 3.53E- 01 47.8 LYM14 2 12802. 9 M 0.16 4 5.37E- 01 9.5 LYM4 11706. 5 B 0.29 6 3.55E- 01 33.9 LYM10 0 12131. 3 M 0.16 2 5.51E- 01 8.2 LYM13 2 12275. 1 B 0.28 9 3.63E- 01 30.8 LYM10 2 12222. 6 M 0.16 3 5.63E- 01 8.5 LYM12 9 12572. 2 B 0.30 3 3.87E- 01 37.3 LYM28 7 12774. 6 M 0.16 6.30E- 01 6.7 LYM13 11773. 2 B 0.31 4 3.98E- 01 42.1 LYM13 0 12333. 1 M 0.15 9 6.78E- 01 6 LYM14 3 12521. 2 B 0.26 4 4.18E- 01 19.7 LYM19 8 13005. 8 M 0.15 8 6.94E- 01 5.4 LYM14 3 12523. 4 B 0.27 4 4.27E- 01 24.3 LYM18 3 12993. 7 M 0.15 9 7.00E- 01 5.7 LYM11 3 12441. 4 B 0.27 8 4.50E- 01 25.7 LYM10 6 12142. 3 M 0.15 8 7.00E- 01 5.3 LYM10 6 12141. 4 B 0.25 4 4.54E- 01 15.1 LYM18 3 12994. 7 M 0.15 8 7.06E- 01 5.3 LYM13 11772. 1 B 0.27 4.61E- 01 22.3 LYM20 1 12834. 6 M 0.15 8 7.14E- 01 5 LYM9 11632. 1 B 0.31 9 4.74E- 01 44.4 LYM29 1 12753. 6 M 0.15 8 7.29E- 01 5.1 LYM11 1 12254. 3 B 0.33 5 4.82E- 01 51.7 LYM28 7 12771. 6 M 0.15 7 7.30E- 01 4.7 LYM15 3 12324. 2 B 0.30 4 4.85E- 01 37.6 LYM28 7 12773. 7 M 0.15 8 7.39E- 01 5.1 LYM10 6 12144. 4 B 0.23 3 4.92E- 01 5.6 LYM21 2 13031. 6 M 0.15 7 7.40E- 01 4.4 2016213786 11 Aug 2016 282 Gene name Event I D Mea n P value % incr. vs. cont. Gene name Event I D Mea n P value % incr. vs. cont. LYM1 11602. 1 B 0.23 6 4.95E- 01 6.7 LYM27 0 12871. 5 M 0.15 9 7.48E- 01 5.7 LYM13 0 12332. 2 B 0.23 2 4.98E- 01 5 LYM44 11885. 4 M 0.15 7 7.56E- 01 4.4 LYM2 11695. 3 B 0.25 1 5.12E- 01 13.5 LYM21 2 13034. 9 M 0.15 8 7.63E- 01 5.5 LYM14 1 12404. 1 B 0.27 8 5.13E- 01 25.7 LYM10 7 12632. 1 M 0.15 6 7.80E- 01 4 LYM14 1 12402. 4 B 0.24 3 5.22E- 01 10.1 LYM17 3 12982. 6 M 0.15 4 8.61E- 01 2.4 LYM16 11624. 6 B 0.29 1 5.38E- 01 31.9 LYM20 1 12833. 7 M 0.15 3 8.72E- 01 2.2 LYM13 4 12311. 2 B 0.28 9 5.54E- 01 31.1 LYM44 11882. 1 M 0.15 1 9.64E- 01 0.7 LYM11 1 12251. 1 B 0.33 8 5.57E- 01 53.1 LYM20 8 13012. 5 M 0.15 1 9.83E- 01 0.4 LYM14 1 12404. 4 B 0.26 1 5.64E- 01 18 CONTR OL _ M 0.15 _ 0 LYM17 11684. 4 B 0.23 5.76E- 01 4.2 LYM13 8 12561. 1 N 0.26 1 1.30E- 05 49 LYM10 6 12142. 1 B 0.29 3 5.87E- 01 32.8 LYM28 9 12493. 1 N 0.23 4 7.05E- 04 33.6 LYM13 4 12314. 2 B 0.24 1 6.43E- 01 9.3 LYM17 4 12414. 3 N 0.22 9 2.54E- 03 30.8 LYM10 0 12131. 3 B 0.25 1 6.43E- 01 13.8 LYM11 9 12461. 1 N 0.22 7 3.16E- 03 29.7 LYM10 11742. 1 B 0.26 7 6.69E- 01 20.9 LYM13 8 12561. 3 N 0.22 5 3.66E- 03 28.5 LYM11 1 12251. 3 B 0.23 9 6.76E- 01 8.4 LYM11 9 12461. 4 N 0.22 4 5.01E- 03 27.8 LYM11 1 12252. 2 B 0.22 9 6.87E- 01 3.9 LYM17 4 12411. 3 N 0.22 5 7.02E- 03 28.9 LYM16 11623. 5 B 0.25 9 6.97E- 01 17.2 LYM10 6 12142. 2 N 0.22 6 8.45E- 03 29.3 LYM10 6 12142. 2 B 0.23 3 6.99E- 01 5.6 LYM15 3 12323. 2 N 0.21 6 1.61E- 02 23.5 LYM14 8 12173. 1 B 0.22 9 7.02E- 01 3.6 LYM15 3 12324. 1 N 0.21 7 1.92E- 02 23.8 LYM15 2 12373. 1 B 0.22 9 7.02E- 01 3.9 LYM11 9 12463. 2 N 0.21 2 3.04E- 02 21 LYM13 4 12312. 3 B 0.24 5 7.07E- 01 11 LYM22 0 12851. 8 N 0.21 2 3.13E- 02 21.2 LYM29 0 12504. 1 B 0.28 3 7.08E- 01 28 LYM28 9 12493. 2 N 0.21 7 3.21E- 02 24.2 LYM16 11623. 2 B 0.25 7.31E- 01 13.2 LYM17 4 12412. 1 N 0.21 4 3.22E- 02 22.5 LYM2 11695. 1 B 0.27 7 7.60E- 01 25.4 LYM13 7 12151. 4 N 0.20 8 4.03E- 02 19.1 LYM16 2 12231. 1 B 0.23 5 7.79E- 01 6.4 LYM28 8 12743. 5 N 0.21 3 4.24E- 02 21.5 LYM2 11692. 3 B 0.25 1 7.87E- 01 13.5 LYM10 5 12295. 2 N 0.21 4.60E- 02 19.9 2016213786 11 Aug 2016 283 Gene name Event I D Mea n P value % incr. vs. cont. Gene name Event I D Mea n P value % incr. vs. cont. LYM11 3 12443. 1 B 0.26 1 7.97E- 01 18 LYM25 5 13082. 8 N 0.21 5.20E- 02 20.1 LYM15 2 12372. 2 B 0.23 5 8.07E- 01 6.4 LYM11 9 12462. 1 N 0.21 1 5.82E- 02 20.8 LYM14 3 12521. 1 B 0.22 6 8.11E- 01 2.5 LYM13 0 12332. 1 N 0.20 7 5.93E- 02 18.4 LYM13 0 12334. 1 B 0.25 9 8.16E- 01 17.2 LYM10 7 12632. 3 N 0.20 7 6.68E- 02 18.4 LYM15 3 12324. 1 B 0.24 4 8.17E- 01 10.7 LYM15 3 12324. 2 N 0.20 4 7.50E- 02 16.6 LYM13 7 12154. 5 B 0.22 6 8.28E- 01 2.2 LYM11 9 12462. 2 N 0.20 8 7.54E- 02 19 LYM15 11614. 4 B 0.23 3 8.31E- 01 5.3 LYM10 5 12293. 1 N 0.20 5 7.59E- 02 17.3 LYM16 11622. 2 B 0.23 3 8.34E- 01 5.6 LYM15 2 12371. 3 N 0.20 5 7.65E- 02 17.4 LYM28 9 12493. 6 B 0.24 9 8.38E- 01 12.7 LYM25 5 13082. 7 N 0.20 7 8.60E- 02 18.1 LYM1 11604. 4 B 0.23 4 8.63E- 01 6.2 LYM11 1 12252. 2 N 0.20 3 9.29E- 02 16.2 LYM28 9 12491. 1 B 0.23 5 8.75E- 01 6.4 LYM10 2 12222. 2 N 0.20 2 1.09E- 01 15.6 LYM21 11673. 1 B 0.22 6 8.75E- 01 2.5 LYM25 5 13082. 5 N 0.20 7 1.17E- 01 18.2 LYM13 2 12271. 4 B 0.22 9 9.38E- 01 3.6 LYM13 7 12151. 2 N 0.20 4 1.18E- 01 16.5 LYM1 11603. 2 B 0.22 2 9.68E- 01 0.5 LYM10 6 12144. 4 N 0.19 9 1.21E- 01 14 LYM13 8 12561. 3 B 0.22 3 9.70E- 01 0.8 LYM14 3 12524. 7 N 0.20 4 1.42E- 01 16.6 LYM15 2 12371. 2 B 0.22 1 9.92E- 01 0.2 LYM28 8 12743. 9 N 0.19 8 1.48E- 01 13.3 CONTR OL _ B 0.22 1 _ 0 LYM15 3 12321. 2 N 0.19 8 1.63E- 01 13.4 LYM9 11632. 2 C 3.26 9 4.30E- 05 64 LYM15 2 12371. 2 N 0.20 4 1.67E- 01 16.5 LYM4 11705. 2 C 2.99 3 1.48E- 04 50.1 LYM10 5 12294. 2 N 0.19 6 1.85E- 01 11.8 LYM17 11682. 1 C 2.73 1 8.43E- 04 37 LYM15 3 12322. 1 N 0.19 6 1.90E- 01 11.8 LYM4 11706. 3 C 3.39 4 2.46E- 03 70.2 LYM10 5 12297. 2 N 0.19 6 1.90E- 01 11.9 LYM12 9 12573. 3 C 3.10 6 2.83E- 03 55.8 LYM13 7 12151. 1 N 0.19 6 2.05E- 01 11.8 LYM13 0 12333. 1 C 2.68 1 3.58E- 03 34.5 LYM14 2 12804. 1 N 0.19 8 2.08E- 01 13.3 LYM4 11702. 3 C 3.1 4.05E- 03 55.5 LYM15 2 12373. 1 N 0.19 6 2.17E- 01 11.8 LYM13 8 12561. 1 C 2.53 1 5.20E- 03 27 LYM17 4 12411. 2 N 0.19 6 2.21E- 01 12.1 LYM13 11771. 6 C 2.75 6 6.82E- 03 38.3 LYM19 7 12821. 6 N 0.19 4 2.27E- 01 10.6 2016213786 11 Aug 2016 284 Gene name Event I D Mea n P value % incr. vs. cont. Gene name Event I D Mea n P value % incr. vs. cont. LYM15 11612. 3 C 2.49 4 7.56E- 03 25.1 LYM13 0 12334. 1 N 0.19 3 2.39E- 01 10.3 LYM9 11634. 5 c 2.63 1 1.39E- 02 32 LYM10 2 12222. 3 N 0.19 3 2.51E- 01 10.3 LYM12 9 12573. 5 c 3.51 9 1.43E- 02 76.5 LYM13 0 12332. 2 N 0.19 1 3.09E- 01 9.2 LYM17 11683. 1 c 2.39 4 2.12E- 02 20.1 LYM29 1 12754. 9 N 0.19 4 3.10E- 01 10.7 LYM12 9 12571. 3 c 2.76 3 2.21E- 02 38.6 LYM10 6 12144. 3 N 0.19 2 3.17E- 01 9.9 LYM10 6 12144. 4 c 2.40 6 2.27E- 02 20.7 LYM27 0 12873. 6 N 0.19 3.42E- 01 8.7 LYM19 11751. 5 c 2.35 6 3.15E- 02 18.2 LYM10 2 12222. 1 N 0.19 3.58E- 01 8.6 LYM4 11701. 1 c 2.84 4 3.92E- 02 42.6 LYM10 2 12221. 1 N 0.18 8 3.97E- 01 7.6 LYM11 3 12441. 4 c 2.64 4 4.19E- 02 32.6 LYM13 7 12153. 1 N 0.18 8 3.97E- 01 7.7 LYM17 11684. 4 c 2.35 6 5.63E- 02 18.2 LYM17 3 12981. 6 N 0.18 8 3.98E- 01 7.7 LYM12 9 12572. 4 c 3.03 8 5.70E- 02 52.4 LYM90 12395. 3 N 0.18 9 4.04E- 01 8.2 LYM15 11611. 3 c 2.3 5.79E- 02 15.4 LYM10 7 12631. 2 N 0.18 9 4.08E- 01 8.1 LYM11 9 12463. 2 c 3.41 9 8.18E- 02 71.5 LYM44 11882. 1 N 0.18 8 4.49E- 01 7.4 LYM1 11602. 1 c 2.28 1 8.53E- 02 14.4 LYM17 3 12981. 5 N 0.18 7 4.84E- 01 6.6 LYM14 8 12171. 2 c 2.37 5 1.08E- 01 19.1 LYM14 3 12524. 5 N 0.18 9 5.07E- 01 7.9 LYM15 2 12373. 2 c 2.77 5 1.08E- 01 39.2 LYM24 2 13052. 5 N 0.18 6 5.08E- 01 6.2 LYM4 11706. 5 c 3.06 9 1.20E- 01 53.9 LYM13 0 12331. 3 N 0.18 9 5.20E- 01 8.2 LYM9 11633. 7 c 3.06 3 1.26E- 01 53.6 LYM28 8 12743. 8 N 0.18 5 5.30E- 01 6 LYM10 6 12144. 3 c 2.24 4 1.58E- 01 12.6 LYM13 8 12564. 1 N 0.18 5 5.54E- 01 5.8 LYM14 1 12402. 4 c 2.38 1 1.63E- 01 19.4 LYM28 9 12492. 2 N 0.18 4 5.60E- 01 5.3 LYM16 11624. 4 c 2.42 5 1.90E- 01 21.6 LYM13 7 12154. 5 N 0.18 6 5.68E- 01 6.4 LYM13 11773. 2 c 2.61 9 1.93E- 01 31.4 LYM13 8 12562. 2 N 0.18 3 6.21E- 01 4.8 LYM10 6 12142. 2 c 2.3 1.99E- 01 15.4 LYM28 9 12491. 4 N 0.18 2 6.68E- 01 3.8 LYM13 7 12154. 5 c 2.3 1.99E- 01 15.4 LYM10 6 12141. 4 N 0.18 1 6.80E- 01 3.6 LYM13 2 12275. 1 c 2.27 5 2.02E- 01 14.1 LYM18 3 12994. 7 N 0.18 1 6.90E- 01 3.7 LYM15 3 12323. 2 c 2.48 1 2.07E- 01 24.5 LYM10 7 12631. 4 N 0.18 1 6.97E- 01 3.5 2016213786 11 Aug 2016 285 Gene name Event I D Mea n P value % incr. vs. cont. Gene name Event I D Mea n P value % incr. vs. cont. LYM9 11633. 2 C 2.35 6 2.33E- 01 18.2 LYM28 9 12491. 1 N 0.18 7.34E- 01 3 LYM13 4 12314. 2 c 2.28 8 2.41E- 01 14.7 LYM27 0 12871. 8 N 0.18 1 7.36E- 01 3.7 LYM12 9 12572. 2 c 3 2.69E- 01 50.5 LYM14 2 12804. 3 N 0.18 1 7.40E- 01 3.7 LYM13 4 12312. 3 c 2.2 2.70E- 01 10.4 LYM24 2 13051. 8 N 0.18 7.41E- 01 3 LYM11 3 12442. 1 c 2.68 1 2.75E- 01 34.5 LYM44 11885. 3 N 0.18 1 7.62E- 01 3.2 LYM13 11772. 1 c 2.48 1 2.80E- 01 24.5 LYM18 3 12994. 8 N 0.18 1 7.66E- 01 3.7 LYM14 8 12173. 1 c 2.15 2.91E- 01 7.8 LYM10 6 12142. 3 N 0.17 9 7.88E- 01 2.4 LYM11 9 12461. 1 c 2.28 8 2.95E- 01 14.7 LYM11 1 12254. 4 N 0.17 9 7.89E- 01 2.4 LYM13 11771. 9 c 2.19 4 2.97E- 01 10 LYM10 7 12631. 1 N 0.17 9 7.99E- 01 2.4 LYM14 1 12404. 1 c 2.44 4 3.06E- 01 22.6 LYM20 1 12834. 6 N 0.17 9 8.18E- 01 2.2 LYM16 11624. 6 c 2.68 8 3.41E- 01 34.8 LYM10 0 12131. 3 N 0.17 8 8.46E- 01 1.7 LYM14 8 12174. 1 c 2.42 5 3.45E- 01 21.6 LYM21 2 13032. 8 N 0.17 8 8.59E- 01 1.6 LYM16 11622. 2 c 2.19 4 3.53E- 01 10 LYM20 1 12833. 9 N 0.17 7 8.96E- 01 1.1 LYM9 11632. 1 c 3.00 6 3.58E- 01 50.8 LYM27 0 12871. 5 N 0.17 8 9.11E- 01 1.5 LYM13 0 12331. 3 c 2.21 9 3.60E- 01 11.3 LYM10 5 12294. 3 N 0.17 7 9.14E- 01 1 LYM15 3 12324. 2 c 2.46 9 3.65E- 01 23.8 LYM10 7 12632. 1 N 0.17 7 9.15E- 01 1 LYM16 11623. 2 c 2.41 3 3.71E- 01 21 LYM20 1 12833. 7 N 0.17 6 9.24E- 01 0.8 LYM16 2 12234. 4 c 2.5 3.76E- 01 25.4 LYM13 7 12152. 1 N 0.17 6 9.43E- 01 0.7 LYM11 1 12254. 3 c 2.58 1 4.18E- 01 29.5 LYM20 8 13012. 5 N 0.17 6 9.69E- 01 0.5 LYM11 1 12251. 1 c 2.68 8 4.40E- 01 34.8 LYM19 7 12824. 4 N 0.17 6 9.72E- 01 0.3 LYM17 11681. 4 c 2.11 5 4.53E- 01 6.1 LYM28 8 12744. 6 N 0.17 6 9.74E- 01 0.4 LYM15 11614. 4 c 2.12 5 4.67E- 01 6.6 CONTR OL _ N 0.17 5 _ 0 LYM10 6 12142. 1 c 2.53 1 4.74E- 01 27 LYM17 4 12414. 3 O 2.09 4 1.00E- 06 72.1 LYM10 6 12141. 4 c 2.35 8 4.96E- 01 18.3 LYM28 8 12743. 9 O 1.73 3.30E- 05 42.2 LYM14 3 12521. 2 c 2.18 1 5.05E- 01 9.4 LYM25 5 13082. 8 o 1.71 2 4.70E- 05 40.7 LYM19 11752. 2 c 2.08 1 5.38E- 01 4.4 LYM10 6 12144. 4 o 1.62 4 2.04E- 04 33.5 2016213786 11 Aug 2016 286 Gene name Event I D Mea n P value % incr. vs. cont. Gene name Event I D Mea n P value % incr. vs. cont. LYM16 2 12231. 3 C 2.10 6 5.41E- 01 5.7 LYM27 0 12873. 6 O 1.58 7 4.90E- 04 30.4 LYM11 1 12251. 3 c 2.35 5.87E- 01 17.9 LYM28 9 12492. 2 o 1.51 8 1.30E- 03 24.7 LYM14 1 12404. 4 c 2.16 9 6.33E- 01 00 00* LYM10 5 12294. 2 o 1.49 6 1.87E- 03 22.9 LYM13 7 12151. 2 c 2.05 8 6.54E- 01 3.2 LYM10 7 12631. 4 o 1.48 7 2.26E- 03 22.2 LYM11 1 12254. 4 c 2.18 1 6.62E- 01 9.4 LYM13 0 12332. 1 o 1.92 8 3.71E- 03 58.5 LYM16 11623. 5 c 2.28 1 6.77E- 01 14.4 LYM15 3 12323. 2 o 1.82 8 4.86E- 03 50.3 LYM15 3 12324. 1 c 2.18 1 6.83E- 01 9.4 LYM13 0 12334. 1 o 1.57 8 5.52E- 03 29.7 LYM13 8 12561. 3 c 2.17 5 6.87E- 01 9.1 LYM13 7 12153. 1 o 1.43 5 7.32E- 03 17.9 LYM2 11695. 3 c 2.05 6.93E- 01 2.8 LYM15 3 12324. 2 o 1.68 9 7.63E- 03 38.9 LYM13 7 12151. 1 c 2.05 7.06E- 01 2.8 LYM17 3 12981. 6 o 1.46 3 8.10E- 03 20.2 LYM14 3 12523. 4 c 2.15 6 7.37E- 01 8.2 LYM13 8 12561. 1 o 2.72 6 8.93E- 03 124.1 LYM2 11695. 1 c 2.5 7.66E- 01 25.4 LYM15 3 12322. 1 o 1.43 2 9.89E- 03 17.7 LYM2 11691. 2 c 2.07 5 7.88E- 01 4.1 LYM28 9 12493. 1 o 1.81 8 1.07E- 02 49.5 LYM21 11672. 4 c 2.03 1 7.89E- 01 1.9 LYM11 9 12461. 4 o 2.03 1.16E- 02 66.9 LYM13 7 12152. 1 c 2.06 3 7.91E- 01 3.5 LYM10 2 12222. 2 o 1.67 6 1.46E- 02 37.7 LYM13 0 12332. 2 c 2.03 1 8.44E- 01 1.9 LYM10 2 12222. 3 o 1.45 5 1.94E- 02 19.6 LYM16 2 12231. 1 c 2.12 5 8.45E- 01 6.6 LYM10 5 12297. 2 o 1.59 8 2.07E- 02 31.3 LYM13 4 12311. 2 c 2.08 1 8.49E- 01 4.4 LYM10 7 12631. 2 o 1.38 6 2.27E- 02 14 LYM29 0 12504. 1 c 2.15 8.69E- 01 7.8 LYM13 8 12561. 3 o 2.06 6 3.41E- 02 69.8 LYM16 2 12234. 3 c 2.03 1 9.11E- 01 1.9 LYM11 9 12461. 1 o 1.94 8 6.22E- 02 60.1 LYM13 7 12153. 1 c 2.01 3 9.23E- 01 1 LYM10 5 12293. 1 o 1.69 5 6.63E- 02 39.3 LYM15 2 12373. 1 c 2.00 6 9.33E- 01 0.6 LYM10 6 12141. 4 o 1.38 8 7.61E- 02 14.1 LYM15 2 12371. 2 c 2 9.69E- 01 0.3 LYM21 2 13032. 8 o 1.44 9 7.79E- 02 19.1 LYM10 11742. 1 c 2.01 3 9.70E- 01 1 LYM11 9 12463. 2 o 1.91 7 8.15E- 02 57.6 LYM17 11684. 5 c 2.00 6 9.72E- 01 0.6 LYM10 5 12295. 2 o 1.60 7 8.74E- 02 32.1 LYM28 9 12491. 1 c 2 9.93E- 01 0.3 LYM17 3 12982. 6 o 1.33 2 8.92E- 02 9.5 2016213786 11 Aug 2016 287 Gene name Event I D Mea n P value % incr. vs. cont. Gene name Event I D Mea n P value % incr. vs. cont. CONTR OL _ C 1.99 4 _ 0 LYM11 1 12254. 4 O 1.43 9.17E- 02 17.6 LYM14 8 12171. 2 D 0.36 2 3.00E- 06 59.2 LYM17 4 12411. 2 o 1.72 4 1.04E- 01 41.7 LYM14 3 12524. 7 D 0.34 4 1.40E- 05 51.3 LYM22 0 12851. 8 o 1.88 6 1.22E- 01 55 LYM1 11602. 1 D 0.31 3 8.90E- 05 37.7 LYM10 5 12294. 3 o 1.35 6 1.28E- 01 11.4 LYM13 0 12333. 1 D 0.30 9 1.24E- 04 36 LYM13 7 12151. 4 o 1.63 3 1.38E- 01 34.2 LYM10 11744. 1 D 0.30 1 2.98E- 04 32.6 LYM17 4 12412. 1 o 1.84 7 1.64E- 01 51.8 LYM10 11741. 2 D 0.38 2 3.43E- 04 67.9 LYM10 6 12142. 2 o 1.98 4 1.65E- 01 63.1 LYM16 2 12234. 3 D 0.29 9 4.64E- 04 31.4 LYM13 0 12332. 2 o 1.61 5 1.74E- 01 32.8 LYM10 2 12222. 2 D 0.29 2 6.30E- 04 28.6 LYM24 2 13051. 8 o 1.41 5 1.75E- 01 16.3 LYM15 11614. 3 D 0.29 1 7.21E- 04 28 LYM10 7 12632. 3 o 1.84 6 1.82E- 01 51.7 LYM14 0 12262. 3 D 0.29 7.39E- 04 27.5 LYM15 2 12373. 1 o 1.37 8 2.05E- 01 13.2 LYM4 11706. 5 D 0.28 9 8.21E- 04 27 LYM13 7 12151. 1 o 1.58 2 2.07E- 01 30 LYM10 5 12293. 1 D 0.29 8 8.36E- 04 31 LYM15 3 12324. 1 o 1.77 5 2.09E- 01 45.9 LYM1 11602. 6 D 0.40 6 1.24E- 03 78.7 LYM11 9 12462. 1 o 1.85 1 2.26E- 01 52.1 LYM15 2 12372. 2 D 0.28 6 1.76E- 03 26 LYM13 8 12562. 2 o 1.51 2 2.27E- 01 24.3 LYM13 2 12273. 2 D 0.28 3 1.88E- 03 24.6 LYM28 9 12491. 1 o 1.32 8 2.38E- 01 9.1 LYM13 2 12271. 4 D 0.27 5 3.78E- 03 20.8 LYM17 4 12411. 3 o 1.94 2 2.45E- 01 59.6 LYM17 11684. 4 D 0.27 1 1.10E-02 19.2 LYM13 7 12151. 2 o 1.58 7 2.45E- 01 30.4 LYM11 9 12461. 4 D 0.27 3 1.11E- 02 20 LYM11 1 12252. 2 o 1.54 6 2.55E- 01 27.1 LYM16 2 12231. 3 D 0.27 8 1.15E- 02 22.4 LYM28 8 12743. 8 o 1.46 4 2.62E- 01 20.4 LYM13 11771. 6 D 0.26 2 2.00E- 02 15.2 LYM28 7 12774. 6 o 1.30 3 2.70E- 01 7.1 LYM9 11632. 2 D 0.26 1 2.89E- 02 15 LYM28 8 12743. 5 o 1.78 2.75E- 01 46.3 LYM11 9 12463. 2 D 0.28 5 4.01E- 02 25.5 LYM24 2 13052. 5 o 1.36 5 2.99E- 01 12.2 LYM14 1 12404. 2 D 0.25 5 4.81E- 02 12.1 LYM10 7 12631. 1 o 1.40 7 3.08E- 01 15.7 LYM13 8 12561. 1 D 0.32 8 5.35E- 02 44.5 LYM10 0 12131. 3 o 1.36 3.20E- 01 11.7 LYM19 11751. 5 D 0.29 1 5.76E- 02 28 LYM28 9 12491. 4 o 1.32 2 3.20E- 01 8.7 2016213786 11 Aug 2016 288 Gene name Event I D Mea n P value % incr. vs. cont. Gene name Event I D Mea n P value % incr. vs. cont. LYM19 11753. 1 D 0.27 4 6.46E- 02 20.5 LYM90 12395. 3 O 1.44 3 3.34E- 01 18.6 LYM28 9 12493. 6 D 0.25 3 7.62E- 02 11.2 LYM10 2 12222. 1 o 1.33 9 3.34E- 01 10.1 LYM26 8 12483. 2 D 0.25 6 7.90E- 02 12.7 LYM19 7 12821. 6 o 1.38 5 3.37E- 01 13.8 LYM12 9 12573. 5 D 0.25 1 8.16E- 02 10.4 LYM25 5 13082. 7 o 1.71 1 3.37E- 01 40.7 LYM14 8 12174. 1 D 0.30 3 8.57E- 02 33.3 LYM11 9 12462. 2 o 1.68 8 3.41E- 01 38.8 LYM28 9 12493. 2 D 0.31 l.OOE- 01 36.3 LYM15 2 12371. 2 o 1.79 1 3.57E- 01 47.2 LYM9 11632. 1 D 0.34 4 1.06E- 01 51.2 LYM15 3 12321. 2 o 1.54 5 3.58E- 01 27 LYM1 11604. 4 D 0.32 1 1.12E- 01 41.4 LYM28 7 12771. 6 o 1.28 4 3.68E- 01 5.5 LYM10 11742. 2 D 0.30 3 1.26E- 01 33.2 LYM28 9 12493. 2 o 1.75 2 3.69E- 01 44 LYM1 11603. 2 D 0.28 1.48E- 01 23 LYM10 6 12144. 3 o 1.54 4 3.75E- 01 26.9 LYM11 9 12462. 2 D 0.36 1 1.51E- 01 58.8 LYM25 5 13082. 5 o 1.81 3.83E- 01 48.8 LYM14 3 12521. 1 D 0.25 9 1.56E- 01 14.1 LYM28 8 12741. 9 o 1.47 9 4.12E- 01 21.6 LYM17 11681. 4 D 0.24 9 1.61E- 01 9.6 LYM13 8 12564. 1 o 1.45 2 4.26E- 01 19.3 LYM13 11772. 1 D 0.24 8 1.66E- 01 9.1 LYM29 1 12754. 9 o 1.53 8 4.35E- 01 26.4 LYM11 9 12462. 1 D 0.29 8 1.76E- 01 31.1 LYM10 2 12221. 1 o 1.35 3 4.81E- 01 11.2 LYM15 11612. 2 D 0.26 3 1.80E- 01 15.8 LYM15 2 12371. 3 o 1.44 8 4.88E- 01 19 LYM10 2 12221. 1 D 0.24 4 1.81E- 01 7.3 LYM25 5 13082. 9 o 1.35 6 5.04E- 01 11.5 LYM17 4 12411. 2 D 0.30 4 1.83E- 01 33.9 LYM13 0 12331. 3 o 1.58 9 5.44E- 01 30.6 LYM16 11624. 4 D 0.24 4 1.94E- 01 7.2 LYM21 2 13031. 6 o 1.27 2 5.47E- 01 4.5 LYM21 11673. 1 D 0.26 1.96E- 01 14.4 LYM14 3 12524. 7 o 1.49 2 5.72E- 01 22.7 LYM17 11684. 5 D 0.24 2 2.39E- 01 6.4 LYM17 3 12981. 5 o 1.33 1 5.74E- 01 9.4 LYM13 8 12561. 3 D 0.32 1 2.41E- 01 41.1 LYM10 6 12142. 3 o 1.26 7 5.74E- 01 4.2 LYM4 11705. 2 D 0.27 3 2.47E- 01 20.2 LYM14 2 12802. 9 o 1.38 5.91E- 01 13.4 LYM13 8 12562. 1 D 0.24 2 2.58E- 01 6.5 LYM19 8 13005. 8 o 1.27 3 5.92E- 01 4.6 LYM14 1 12404. 3 D 0.27 4 2.69E- 01 20.7 LYM10 2 12222. 6 o 1.34 5 6.01E- 01 10.5 LYM17 11683. 1 D 0.24 2 2.69E- 01 6.3 LYM13 7 12154. 5 o 1.54 4 6.05E- 01 26.9 2016213786 11 Aug 2016 289 Gene name Event I D Mea n P value % incr. vs. cont. Gene name Event I D Mea n P value % incr. vs. cont. LYM19 11754. 1 D 0.26 1 2.73E- 01 15 LYM20 1 12834. 6 O 1.28 7 7.03E- 01 5.8 LYM15 2 12371. 2 D 0.27 1 2.75E- 01 19.3 LYM18 3 12994. 8 o 1.41 4 7.10E- 01 16.2 LYM13 0 12334. 1 D 0.24 5 2.83E- 01 7.7 LYM44 11885. 4 o 1.28 2 7.27E- 01 5.4 LYM13 4 12311. 2 D 0.28 4 3.00E- 01 25 LYM24 2 13053. 7 o 1.26 2 7.36E- 01 3.7 LYM14 1 12402. 4 D 0.29 6 3.09E- 01 30.2 LYM10 7 12632. 1 o 1.28 9 7.44E- 01 5.9 LYM2 11692. 3 D 0.24 2 3.13E- 01 6.6 LYM29 1 12753. 6 o 1.29 2 7.51E- 01 6.2 LYM9 11633. 7 D 0.27 7 3.20E- 01 22 LYM14 3 12524. 5 o 1.36 6 7.58E- 01 12.2 LYM19 11751. 4 D 0.29 2 3.24E- 01 28.3 LYM20 1 12833. 7 o 1.24 1 7.73E- 01 2 LYM16 2 12231. 1 D 0.27 9 3.32E- 01 22.6 LYM13 0 12333. 1 o 1.29 4 7.92E- 01 6.4 LYM14 8 12173. 1 D 0.28 9 3.33E- 01 27.2 LYM28 7 12773. 7 o 1.29 3 8.02E- 01 6.2 LYM14 3 12524. 2 D 0.26 3 3.48E- 01 15.6 LYM18 3 12993. 7 o 1.27 8 8.25E- 01 5 LYM15 11612. 3 D 0.28 5 3.59E- 01 25.4 LYM27 0 12871. 5 o 1.29 2 8.85E- 01 6.2 LYM28 9 12491. 1 D 0.28 1 3.79E- 01 23.7 LYM18 3 12994. 7 o 1.24 8.96E- 01 2 LYM13 0 12332. 2 D 0.27 4 3.79E- 01 20.6 LYM21 2 13034. 9 o 1.27 9.25E- 01 4.4 LYM17 4 12414. 3 D 0.31 3 3.80E- 01 37.5 LYM20 8 13012. 5 o 1.24 9 9.35E- 01 2.7 LYM10 0 12133. 1 D 0.25 2 3.84E- 01 10.8 CONTR OL _ o 1.21 7 _ 0 LYM14 1 12404. 4 D 0.27 3.96E- 01 18.9 LYM28 9 12493. 1 P 2.45 7 6.00E- 06 34.4 LYM16 2 12234. 4 D 0.30 7 4.01E- 01 35 LYM15 3 12323. 2 P 2.34 8 3.90E- 05 28.5 LYM21 11671. 2 D 0.25 2 4.34E- 01 11.1 LYM13 8 12561. 1 P 2.89 6 4.80E- 05 58.4 LYM15 11611. 3 D 0.28 6 4.64E- 01 25.9 LYM28 8 12743. 9 P 2.27 8 1.08E- 04 24.6 LYM10 11744. 5 D 0.26 3 4.65E- 01 15.5 LYM10 6 12144. 4 P 2.16 2 1.09E- 03 18.3 LYM17 4 12412. 1 D 0.28 3 4.68E- 01 24.5 LYM13 0 12334. 1 P 2.12 3 1.12E- 03 16.2 LYM17 4 12411. 3 D 0.25 9 4.73E- 01 13.9 LYM10 5 12297. 2 P 2.12 3 1.13E- 03 16.1 LYM28 9 12491. 4 D 0.25 4.85E- 01 9.9 LYM17 3 12981. 6 P 2.08 8 2.27E- 03 14.2 LYM11 3 12442. 1 D 0.23 5 5.12E- 01 3.6 LYM10 5 12293. 1 P 2.25 2 3.65E- 03 23.2 LYM14 3 12521. 2 D 0.24 4 5.14E- 01 7.1 LYM10 5 12294. 2 P 2.06 1 3.93E- 03 12.8 2016213786 11 Aug 2016 290 Gene name Event I D Mea n P value % incr. vs. cont. Gene name Event I D Mea n P value % incr. vs. cont. LYM10 2 12222. 3 D 0.27 4 5.18E- 01 20.7 LYM13 7 12153. 1 P 2.05 7 4.42E- 03 12.5 LYM11 1 12251. 1 D 0.26 4 5.22E- 01 16.1 LYM19 7 12821. 6 P 2.05 8 4.44E- 03 12.6 LYM17 11682. 1 D 0.27 2 5.33E- 01 19.6 LYM13 8 12561. 3 P 2.48 7 6.03E- 03 36.1 LYM26 8 12483. 4 D 0.25 8 5.50E- 01 13.3 LYM10 7 12631. 4 P 2.03 4 7.95E- 03 11.3 LYM21 11672. 4 D 0.26 5 5.55E- 01 16.5 LYM10 2 12222. 3 P 2.07 9 9.12E- 03 13.8 LYM29 0 12502. 4 D 0.25 5 6.03E- 01 12.4 LYM11 1 12254. 4 P 2.01 3 1.74E- 02 10.1 LYM26 8 12482. 3 D 0.23 9 6.08E- 01 5.1 LYM10 2 12222. 1 P 2.01 9 1.77E- 02 10.5 LYM29 0 12501. 3 D 0.24 2 6.70E- 01 6.6 LYM10 6 12141. 4 P 1.99 9 1.86E- 02 9.4 LYM10 5 12294. 2 D 0.26 3 7.15E- 01 15.6 LYM11 9 12463. 2 P 2.42 7 2.00E- 02 32.8 LYM10 0 12131. 3 D 0.24 6 7.22E- 01 8.2 LYM15 3 12322. 1 P 2.02 5 2.34E- 02 10.8 LYM11 1 12252. 2 D 0.25 2 7.44E- 01 10.7 LYM27 0 12873. 6 P 2.19 2.39E- 02 19.8 LYM1 11601. 1 D 0.24 1 7.48E- 01 6.1 LYM10 2 12222. 2 P 2.26 2.62E- 02 23.6 LYM22 11762. 1 D 0.23 6 7.59E- 01 3.6 LYM13 7 12151. 4 P 2.24 7 2.89E- 02 22.9 LYM14 8 12172. 1 D 0.25 1 7.85E- 01 10.2 LYM17 4 12414. 3 P 2.53 3 2.94E- 02 38.6 LYM26 8 12482. 1 D 0.24 3 8.20E- 01 6.9 LYM21 2 13032. 8 P 2.00 4 3.00E- 02 9.6 LYM13 7 12153. 1 D 0.24 8.22E- 01 5.4 LYM15 2 12373. 1 P 2.09 4 4.88E- 02 14.6 LYM10 11742. 1 D 0.24 3 8.33E- 01 7.1 LYM10 2 12221. 1 P 1.96 9 5.91E- 02 7.7 LYM16 2 12233. 2 D 0.23 6 8.50E- 01 3.7 LYM11 9 12461. 4 P 2.48 3 6.35E- 02 35.8 LYM14 0 12261. 4 D 0.23 4 8.56E- 01 2.9 LYM13 0 12332. 2 P 2.18 3 6.35E- 02 19.5 LYM29 0 12502. 1 D 0.23 4 8.96E- 01 3.1 LYM15 3 12324. 2 P 2.20 7 6.58E- 02 20.7 LYM14 3 12523. 4 D 0.23 2 9.21E- 01 1.9 LYM28 9 12492. 2 P 2.06 3 6.71E- 02 12.8 LYM9 11633. 2 D 0.23 9.45E- 01 1.4 LYM17 3 12982. 6 P 1.94 4 7.81E- 02 6.4 LYM11 1 12254. 4 D 0.22 8 9.48E- 01 0.3 LYM28 9 12493. 2 P 2.30 7 8.42E- 02 26.2 LYM15 2 12373. 2 D 0.22 7 9.98E- 01 0 LYM13 7 12151. 1 P 2.14 5 9.13E- 02 17.3 CONTR OL _ D 0.22 7 _ 0 LYM22 0 12851. 8 P 2.29 4 9.18E- 02 25.5 LYM4 11706. 5 E 8.93 8 2.20E- 05 18.6 LYM10 0 12131. 3 P 2.00 1 1.04E- 01 9.5 2016213786 11 Aug 2016 291 Gene name Event I D Mea n P value % incr. vs. cont. Gene name Event I D Mea n P value % incr. vs. cont. LYM10 2 12222. 2 E 8.87 5 3.70E- 05 17.8 LYM13 0 12332. 1 P 2.43 7 1.12E- 01 33.4 LYM11 9 12462. 2 E 8.86 6 3.80E- 05 17.7 LYM11 9 12461. 1 P 2.38 3 1.15E- 01 30.4 LYM13 8 12561. 1 E 8.81 3 4.40E- 05 16.9 LYM24 2 13051. 8 P 2.01 1 1.19E- 01 10 LYM10 11742. 2 E 8.68 8 9.10E- 05 15.3 LYM28 8 12743. 5 P 2.29 9 1.24E- 01 25.8 LYM10 5 12293. 1 E 8.56 3 2.01E- 04 13.6 LYM10 6 12142. 2 P 2.41 1 1.25E- 01 31.9 LYM15 2 12372. 2 E 8.56 3 2.01E- 04 13.6 LYM10 5 12295. 2 P 2.24 3 1.29E- 01 22.7 LYM1 11602. 6 E 9.12 5 7.59E- 04 21.1 LYM10 5 12294. 3 P 1.95 3 1.30E- 01 6.9 LYM19 11753. 1 E 8.31 3 1.23E- 03 10.3 LYM10 7 12631. 2 P 2.02 2 1.32E- 01 10.7 LYM1 11603. 2 E 8.25 1.75E- 03 9.5 LYM15 3 12324. 1 P 2.30 9 1.37E- 01 26.3 LYM10 11744. 1 E 8.12 5 4.92E- 03 7.8 LYM17 4 12412. 1 P 2.35 9 1.38E- 01 29.1 LYM13 0 12333. 1 E 8.37 5 9.64E- 03 11.1 LYM17 4 12411. 2 P 2.25 8 1.41E- 01 23.5 LYM13 2 12271. 4 E 8.37 5 9.64E- 03 11.1 LYM24 2 13052. 5 P 2.00 2 1.43E- 01 9.5 LYM17 4 12414. 3 E 8.37 5 9.64E- 03 11.1 LYM10 7 12632. 3 P 2.32 6 1.47E- 01 27.2 LYM10 11741. 2 E 9.06 3 1.38E- 02 20.3 LYM10 6 12144. 3 P 2.13 1 1.69E- 01 16.6 LYM13 0 12332. 2 E 8.68 8 2.64E- 02 15.3 LYM17 4 12411. 3 P 2.45 8 1.72E- 01 34.5 LYM13 0 12334. 1 E 8.68 8 2.64E- 02 15.3 LYM21 2 13031. 6 P 1.96 9 1.78E- 01 7.7 LYM14 1 12402. 4 E 8.68 8 2.64E- 02 15.3 LYM15 2 12371. 3 P 2.06 1.86E- 01 12.7 LYM11 3 12442. 1 E 7.93 8 3.53E- 02 5.3 LYM25 5 13082. 8 P 2.31 2 2.00E- 01 26.5 LYM9 11632. 1 E 8.43 8 4.54E- 02 12 LYM15 3 12321. 2 P 2.11 2.02E- 01 15.4 LYM14 3 12524. 7 E 9 4.73E- 02 19.4 LYM11 9 12462. 1 P 2.41 8 2.08E- 01 32.3 LYM13 2 12275. 1 E 7.87 5 5.28E- 02 4.5 LYM24 2 13053. 7 P 1.91 4 2.14E- 01 4.7 LYM9 11633. 7 E 7.87 5 5.28E- 02 4.5 LYM28 8 12743. 8 P 2.07 2 2.20E- 01 13.4 LYM17 11681. 4 E 7.91 7 5.73E- 02 5.1 LYM28 9 12491. 1 P 1.95 9 2.38E- 01 7.2 LYM10 0 12133. 1 E 8.31 3 6.24E- 02 10.3 LYM11 1 12252. 2 P 2.14 8 2.40E- 01 17.5 LYM11 9 12461. 4 E 8.31 3 6.24E- 02 10.3 LYM25 5 13082. 9 P 1.99 8 2.41E- 01 9.3 LYM21 11672. 4 E 8 6.71E- 02 6.2 LYM11 9 12462. 2 P 2.21 8 2.61E- 01 21.3 2016213786 11 Aug 2016 292 Gene name Event I D Mea n P value % incr. vs. cont. Gene name Event I D Mea n P value % incr. vs. cont. LYM17 11684. 4 E 8.18 8 8.91E- 02 8.6 LYM13 7 12151. 2 P 2.21 2 2.66E- 01 21 LYM19 11751. 5 E 8.18 8 8.91E- 02 8.6 LYM28 9 12491. 4 P 1.92 5 2.70E- 01 5.3 LYM14 3 12524. 2 E 7.81 3 1.19E- 01 3.7 LYM10 7 12631. 1 P 1.99 8 2.73E- 01 9.3 LYM15 11614. 3 E 7.81 3 1.19E- 01 3.7 LYM10 6 12142. 3 P 1.93 1 2.87E- 01 5.6 LYM14 8 12171. 2 E 8.06 3 1.33E- 01 7 LYM13 8 12562. 2 P 2.04 4 3.08E- 01 11.8 LYM16 2 12231. 3 E 8.06 3 1.33E- 01 7 LYM25 5 13082. 5 P 2.27 3.12E- 01 24.2 LYM19 11754. 1 E 8.06 3 1.33E- 01 7 LYM25 5 13082. 7 P 2.20 9 3.30E- 01 20.9 LYM14 1 12404. 2 E 7.87 5 1.45E- 01 4.5 LYM15 2 12371. 2 P 2.28 3 3.57E- 01 24.9 LYM28 9 12491. 4 E 7.87 5 1.45E- 01 4.5 LYM90 12395. 3 P 2.04 1 3.80E- 01 11.7 LYM11 9 12463. 2 E 8.25 1.49E- 01 9.5 LYM28 7 12771. 6 P 1.87 8 3.99E- 01 2.8 LYM28 9 12493. 2 E 8.25 1.49E- 01 9.5 LYM10 7 12632. 1 P 1.94 4 4.04E- 01 6.4 LYM16 2 12234. 3 E 8.43 8 1.63E- 01 12 LYM10 2 12222. 6 P 1.94 2 4.04E- 01 6.2 LYM14 8 12174. 1 E 8.62 5 1.74E- 01 14.5 LYM28 8 12741. 9 P 2.04 4.14E- 01 11.6 LYM14 0 12262. 3 E 7.75 1.85E- 01 2.8 LYM13 8 12564. 1 P 2.04 9 4.46E- 01 12.1 LYM3 12042. 1 E 7.75 1.85E- 01 2.8 LYM29 1 12754. 9 P 2.07 7 4.54E- 01 13.7 LYM15 11611. 3 E 8.47 9 1.89E- 01 12.5 LYM28 7 12774. 6 P 1.89 9 4.58E- 01 3.9 LYM14 1 12404. 4 E 8.31 3 1.97E- 01 10.3 LYM17 3 12981. 5 P 1.95 9 4.85E- 01 7.2 LYM16 2 12234. 4 E 8.43 8 2.63E- 01 12 LYM13 0 12331. 3 P 2.13 3 4.95E- 01 16.7 LYM28 9 12493. 6 E 8 2.66E- 01 6.2 LYM13 7 12154. 5 P 2.09 5 5.07E- 01 14.6 LYM29 0 12502. 4 E 8 2.66E- 01 6.2 LYM20 1 12834. 6 P 1.97 5.14E- 01 7.8 LYM17 4 12411. 2 E 8.68 8 2.73E- 01 15.3 LYM14 3 12524. 7 P 2.08 8 5.44E- 01 14.2 LYM29 0 12501. 3 E 8.25 2.78E- 01 9.5 LYM20 1 12833. 9 P 1.86 4 5.52E- 01 2 LYM1 11604. 4 E 8.06 3 3.07E- 01 7 LYM14 2 12802. 9 P 1.93 1 5.89E- 01 5.7 LYM21 11673. 1 E 8.06 3 3.07E- 01 7 LYM20 1 12833. 7 P 1.88 3 6.03E- 01 3 LYM17 11683. 1 E 7.75 3.22E- 01 2.8 LYM18 3 12994. 8 P 2.00 6 6.56E- 01 9.7 LYM2 11692. 3 E 7.75 3.22E- 01 2.8 LYM10 0 12133. 3 P 1.85 3 6.64E- 01 1.4 2016213786 11 Aug 2016 293 Gene name Event I D Mea n P value % incr. vs. cont. Gene name Event I D Mea n P value % incr. vs. cont. LYM11 9 12462. 1 E 8.68 8 3.33E- 01 15.3 LYM13 0 12333. 1 P 1.91 3 6.70E- 01 4.7 LYM14 1 12404. 3 E 8.12 5 3.36E- 01 7.8 LYM14 3 12524. 5 P 1.99 6.99E- 01 8.9 LYM10 2 12222. 3 E 8.43 8 3.42E- 01 12 LYM29 1 12753. 6 P 1.89 3 7.11E- 01 3.6 LYM28 9 12491. 1 E 8.75 3.45E- 01 16.1 LYM14 2 12804. 1 P 1.90 1 7.24E- 01 4 LYM13 7 12153. 1 E 7.81 3 3.45E- 01 3.7 LYM14 3 12521. 1 P 1.84 8 7.39E- 01 1.1 LYM14 3 12521. 1 E 7.81 3 3.45E- 01 3.7 LYM44 11885. 4 P 1.86 4 7.91E- 01 2 LYM21 11671. 2 E 8.18 8 3.58E- 01 8.6 LYM27 0 12871. 8 P 1.90 6 8.00E- 01 4.3 LYM17 11682. 1 E 7.93 8 3.99E- 01 5.3 LYM27 0 12871. 5 P 1.94 8.20E- 01 6.1 LYM1 11602. 1 E 8 4.16E- 01 6.2 LYM20 8 13012. 5 P 1.90 1 8.47E- 01 4 LYM15 2 12371. 2 E 8 4.16E- 01 6.2 LYM18 3 12994. 7 P 1.85 7 8.51E- 01 1.6 LYM26 8 12483. 2 E 8 4.16E- 01 6.2 LYM19 8 13005. 8 P 1.84 2 8.74E- 01 0.8 LYM19 11751. 4 E 8.18 8 4.45E- 01 8.6 LYM18 3 12993. 7 P 1.86 5 8.86E- 01 2.1 LYM15 11612. 3 E 8.25 4.51E- 01 9.5 LYM15 2 12372. 2 P 1.86 1 8.88E- 01 1.8 LYM26 8 12482. 3 E 8.06 3 5.16E- 01 7 LYM28 7 12773. 7 P 1.86 8.96E- 01 1.8 LYM13 2 12273. 2 E 7.81 3 5.31E- 01 3.7 LYM14 2 12804. 3 P 1.86 9 9.02E- 01 2.3 LYM13 8 12562. 1 E 7.75 5.45E- 01 2.8 LYM21 2 13034. 9 P 1.87 9.29E- 01 2.3 LYM13 8 12564. 1 E 7.75 5.45E- 01 2.8 LYM44 11882. 1 P 1.84 9 9.29E- 01 1.2 LYM3 12041. 1 E 7.75 5.45E- 01 2.8 LYM25 5 13081. 5 P 1.84 8 9.43E- 01 1.1 LYM14 8 12173. 1 E 8.31 3 5.58E- 01 10.3 LYM13 7 12152. 1 P 1.83 4 9.58E- 01 0.3 LYM26 8 12483. 4 E 7.62 5 5.60E- 01 1.2 LYM17 4 12414. 2 P 1.83 2 9.58E- 01 0.2 LYM10 6 12141. 4 E 7.68 8 5.77E- 01 2 LYM18 3 12993. 5 P 1.83 9 9.59E- 01 0.6 LYM2 11693. 3 E 7.68 8 5.77E- 01 2 LYM27 0 12872. 7 P 1.83 6 9.62E- 01 0.4 LYM9 11633. 2 E 7.68 8 5.77E- 01 2 LYM17 3 12982. 7 P 1.83 6 9.78E- 01 0.4 LYM16 2 12231. 1 E 8 5.91E- 01 6.2 LYM17 3 12981. 8 P 1.83 2 9.86E- 01 0.3 LYM10 5 12294. 2 E 7.87 5 6.19E- 01 4.5 CONTR OL _ P 1.82 8 _ 0 LYM13 8 12561. 3 E 7.87 5 6.19E- 01 4.5 LYM57 12012. 2 A 93.3 2 8.80E- 03 2.5 2016213786 11 Aug 2016 294 Gene name Event I D Mea n P value % incr. vs. cont. Gene name Event I D Mea n P value % incr. vs. cont. LYM17 4 12412. 1 E 7.85 4 6.25E- 01 4.2 LYM14 12054. 2 A 93.0 18 1.70E- 02 2.2 LYM3 12041. 2 E 8.06 3 6.33E- 01 7 LYM14 8 12171. 2 A 93.0 29 1.75E- 02 2.2 LYM10 11742. 1 E 7.81 3 6.40E- 01 3.7 LYM15 2 12373. 1 A 92.6 21 4.54E- 02 1.8 LYM17 4 12411. 3 E 8.12 5 6.61E- 01 7.8 LYM43 11791. 2 A 93.7 04 4.64E- 02 2.9 LYM12 9 12573. 5 E 7.62 5 6.64E- 01 1.2 LYM14 0 12262. 3 A 92.8 65 5.07E- 02 2 LYM10 2 12221. 1 E 7.75 6.70E- 01 2.8 LYM13 2 12273. 2 A 93.0 98 5.40E- 02 2.3 LYM13 4 12311. 2 E 7.75 6.70E- 01 2.8 LYM13 0 12331. 3 A 92.4 87 5.67E- 02 1.6 LYM15 11612. 2 E 7.75 6.70E- 01 2.8 LYM66 11954. 5 A 93.4 27 5.73E- 02 2.6 LYM3 12043. 1 E 7.75 6.70E- 01 2.8 LYM11 9 12461. 4 A 93.2 97 6.70E- 02 2.5 LYM11 1 12251. 1 E 7.87 5 6.83E- 01 4.5 LYM43 11791. 4 A 92.3 85 7.11E- 02 1.5 LYM13 11771. 6 E 7.87 5 6.83E- 01 4.5 LYM24 12063. 3 A 93.2 33 7.13E- 02 2.4 LYM9 11632. 2 E 7.60 7 7.08E- 01 0.9 LYM29 0 12504. 1 A 93.3 5 8.10E- 02 2.6 LYM10 2 12222. 6 E 7.87 5 7.30E- 01 4.5 LYM51 11891. 1 A 92.5 07 8.56E- 02 1.6 LYM17 4 12414. 2 E 7.75 7.43E- 01 2.8 LYM11 9 12462. 1 A 92.3 46 8.64E- 02 1.5 LYM10 0 12131. 3 E 7.81 3 7.57E- 01 3.7 LYM14 12051. 1 A 93.3 18 9.94E- 02 2.5 LYM14 0 12261. 1 E 7.62 5 7.90E- 01 1.2 LYM14 0 12264. 1 A 92.4 5 1.09E- 01 1.6 LYM28 9 12492. 2 E 7.64 3 8.18E- 01 1.4 LYM14 0 12261. 4 A 93.7 06 1.36E- 01 2.9 LYM10 11744. 5 E 7.62 5 8.54E- 01 1.2 LYM10 0 12131. 2 A 92.8 99 1.46E- 01 2.1 LYM2 11695. 3 E 7.62 5 8.54E- 01 1.2 LYM66 11955. 2 A 93.9 05 1.53E- 01 3.2 LYM19 11752. 2 E 7.68 8 8.62E- 01 2 LYM17 4 12411. 2 A 91.9 81 1.83E- 01 1.1 LYM10 6 12142. 2 E 7.56 3 8.70E- 01 0.4 LYM67 11781. 5 A 92.2 97 1.95E- 01 1.4 LYM14 3 12523. 4 E 7.56 3 8.70E- 01 0.4 LYM57 12012. 6 A 92.0 94 1.96E- 01 1.2 LYM15 3 12321. 2 E 7.62 5 8.89E- 01 1.2 LYM95 12124. 4 A 92.0 49 2.11E- 01 1.1 LYM14 8 12172. 1 E 7.56 3 9.62E- 01 0.4 LYM15 2 12372. 2 A 93.0 98 2.28E- 01 2.3 LYM14 8 12174. 2 E 7.56 3 9.62E- 01 0.4 LYM17 2 12302. 2 A 91.9 37 2.30E- 01 1 LYM4 11705. 2 E 7.54 2 9.88E- 01 0.1 LYM11 9 12462. 2 A 92.9 69 2.34E- 01 2.1 2016213786 11 Aug 2016 295 Gene name Event I D Mea n P value % incr. vs. cont. Gene name Event I D Mea n P value % incr. vs. cont. CONTR OL _ E 7.53 6 _ 0 LYM95 12124. 6 A 93.6 93 2.49E- 01 2.9 LYM14 3 12524. 7 F 0.51 2 4.90E- 05 57.7 LYM68 11942. 2 A 91.9 02 2.57E- 01 1 LYM13 8 12561. 1 F 0.50 8 5.30E- 05 56.2 LYM29 0 12502. 4 A 92.1 94 3.14E- 01 1.3 LYM28 9 12493. 2 F 0.48 5 1.47E- 04 49.2 LYM51 11894. 2 A 93.1 54 3.27E- 01 2.3 LYM10 11742. 2 F 0.46 9 2.28E- 04 44.2 LYM53 11844. 2 A 92.7 58 3.35E- 01 1.9 LYM10 2 12222. 2 F 0.47 5 3.63E- 04 46.1 LYM10 0 12131. 3 A 92.1 72 3.40E- 01 1.3 LYM14 8 12174. 1 F 0.45 5 4.47E- 04 40 LYM31 11923. 1 A 92.4 07 3.77E- 01 1.5 LYM13 2 12271. 4 F 0.45 4 4.55E- 04 39.8 LYM67 11782. 6 A 92.1 38 3.82E- 01 1.2 LYM11 9 12463. 2 F 0.44 9.36E- 04 35.6 LYM3 12043. 1 A 91.8 72 4.24E- 01 0.9 LYM19 11754. 1 F 0.44 9.71E- 04 35.6 LYM24 12061. 4 A 94.3 5 4.31E- 01 3.7 LYM13 2 12273. 2 F 0.45 5 1.09E- 03 40.1 LYM14 3 12523. 4 A 92.4 69 4.55E- 01 1.6 LYM10 11741. 2 F 0.52 5 1.40E- 03 61.5 LYM14 12051. 4 A 92.8 27 4.66E- 01 2 LYM10 5 12293. 1 F 0.42 5 2.11E- 03 30.8 LYM17 0 12453. 2 A 91.5 12 4.71E- 01 0.5 LYM19 11753. 1 F 0.43 9 2.71E- 03 35 LYM13 8 12566. 1 A 91.5 08 4.74E- 01 0.5 LYM4 11705. 2 F 0.42 2.85E- 03 29.4 LYM25 4 12472. 3 A 92.4 69 5.07E- 01 1.6 LYM11 9 12461. 4 F 0.41 6 3.48E- 03 28.2 LYM25 4 12474. 4 A 93.0 13 5.16E- 01 2.2 LYM10 11744. 1 F 0.45 9 7.24E- 03 41.1 LYM15 2 12371. 2 A 91.4 63 5.20E- 01 0.5 LYM15 2 12371. 2 F 0.39 9 1.05E- 02 22.8 LYM13 7 12152. 1 A 92.2 31 5.23E- 01 1.3 LYM19 11751. 4 F 0.39 7 1.36E- 02 22.1 LYM14 12052. 5 A 91.5 87 5.37E- 01 0.6 LYM13 0 12334. 1 F 0.48 2 1.68E- 02 48.5 LYM69 11852. 2 A 92.8 9 5.41E- 01 2 LYM13 7 12153. 1 F 0.39 6 1.72E- 02 22 LYM68 11942. 3 A 91.4 29 5.48E- 01 0.4 LYM4 11706. 5 F 0.47 3 1.86E- 02 45.6 LYM43 11792. 2 A 93.0 65 5.58E- 01 2.2 LYM17 4 12414. 3 F 0.51 5 1.92E- 02 58.5 LYM69 11853. 5 A 91.5 2 5.63E- 01 0.5 LYM28 9 12491. 4 F 0.39 9 1.98E- 02 22.7 LYM69 11853. 4 A 91.4 8 5.87E- 01 0.5 LYM14 1 12402. 4 F 0.45 1 2.34E- 02 38.9 LYM67 11782. 4 A 92.5 68 6.01E- 01 1.7 LYM9 11632. 1 F 0.55 7 2.82E- 02 71.3 LYM16 2 12234. 3 A 92.2 61 6.30E- 01 1.4 2016213786 11 Aug 2016 296 Gene name Event I D Mea n P value % incr. vs. cont. Gene name Event I D Mea n P value % incr. vs. cont. LYM14 0 12262. 3 F 0.43 1 3.06E- 02 32.7 LYM13 2 12275. 1 A 91.4 68 6.30E- 01 0.5 LYM13 0 12333. 1 F 0.43 9 3.87E- 02 35 LYM67 11782. 5 A 91.3 78 6.44E- 01 0.4 LYM15 2 12372. 2 F 0.41 2 3.93E- 02 26.7 LYM26 8 12481. 1 A 91.4 41 6.58E- 01 0.5 LYM1 11604. 4 F 0.43 9 4.25E- 02 35.1 LYM31 11921. 3 A 91.5 36 6.83E- 01 0.6 LYM1 11603. 2 F 0.37 7 4.78E- 02 16 LYM95 12121. 4 A 91.6 2 6.87E- 01 0.7 LYM14 1 12404. 3 F 0.37 1 6.69E- 02 14.3 LYM14 3 12524. 2 A 91.6 62 7.07E- 01 0.7 LYM16 2 12231. 1 F 0.43 3 7.48E- 02 33.4 LYM57 12013. 3 A 92.4 76 7.11E- 01 1.6 LYM13 11772. 1 F 0.36 9 7.58E- 02 13.7 LYM62 12022. 4 A 91.9 5 7.18E- 01 1 LYM1 11602. 1 F 0.37 9 7.70E- 02 16.7 LYM26 11824. 1 A 91.6 83 7.41E- 01 0.7 LYM16 2 12231. 3 F 0.39 9 8.40E- 02 22.7 LYM17 4 12412. 1 A 91.3 87 7.62E- 01 0.4 LYM16 11624. 4 F 0.39 5 8.75E- 02 21.6 LYM67 11783. 5 A 91.7 09 7.63E- 01 0.8 LYM13 8 12561. 3 F 0.46 8 8.78E- 02 44 LYM10 5 12293. 1 A 91.7 57 7.81E- 01 0.8 LYM9 11632. 2 F 0.38 5 9.44E- 02 18.5 LYM30 11913. 5 A 91.6 17 7.83E- 01 0.7 LYM14 0 12261. 1 F 0.36 9 9.78E- 02 13.6 LYM95 12124. 5 A 91.3 05 7.91E- 01 0.3 LYM17 11681. 4 F 0.40 8 9.89E- 02 25.5 LYM17 2 12301. 2 A 91.3 51 7.92E- 01 0.4 LYM10 0 12133. 1 F 0.43 2 1.18E- 01 33 LYM43 11791. 5 A 91.2 02 7.93E- 01 0.2 LYM1 11602. 6 F 0.55 4 1.25E- 01 70.6 LYM53 11843. 2 A 94.9 42 7.95E- 01 4.3 LYM17 4 12411. 3 F 0.44 4 1.29E- 01 36.6 LYM17 0 12454. 2 A 91.4 69 7.97E- 01 0.5 LYM28 9 12492. 2 F 0.36 9 1.39E- 01 13.6 LYM11 9 12463. 2 A 91.4 89 8.08E- 01 0.5 LYM16 2 12234. 4 F 0.42 7 1.55E- 01 31.5 LYM11 1 12254. 4 A 91.5 09 8.21E- 01 0.5 LYM14 0 12264. 1 F 0.36 1.58E- 01 10.7 LYM31 11922. 3 A 91.5 75 8.21E- 01 0.6 LYM12 9 12573. 5 F 0.35 9 1.61E- 01 10.5 LYM13 8 12562. 1 A 91.4 48 8.41E- 01 0.5 LYM13 2 12275. 1 F 0.39 9 1.64E- 01 22.9 LYM17 4 12411. 3 A 91.3 86 8.43E- 01 0.4 LYM15 3 12323. 2 F 0.35 8 1.76E- 01 10.2 LYM51 11893. 2 A 91.3 33 8.55E- 01 0.3 LYM21 11673. 1 F 0.41 3 1.80E- 01 27.1 LYM17 0 12453. 3 A 91.3 21 8.70E- 01 0.3 LYM15 11612. 2 F 0.37 8 1.96E- 01 16.3 LYM62 12021. 1 A 91.1 7 8.74E- 01 0.2 2016213786 11 Aug 2016 297 Gene name Event I D Mea n P value % incr. vs. cont. Gene name Event I D Mea n P value % incr. vs. cont. LYM16 2 12234. 3 F 0.42 4 1.97E- 01 30.6 LYM14 0 12261. 2 A 91.3 21 8.80E- 01 0.3 LYM14 1 12404. 4 F 0.41 8 1.98E- 01 28.7 LYM13 4 12312. 4 A 91.2 4 8.83E- 01 0.2 LYM14 8 12171. 2 F 0.45 2 2.19E- 01 39 LYM17 2 12301. 3 A 91.3 64 8.86E- 01 0.4 LYM19 11752. 2 F 0.40 8 2.21E- 01 25.5 LYM15 2 12372. 1 A 91.1 44 8.89E- 01 0.1 LYM11 9 12462. 2 F 0.45 7 2.36E- 01 40.7 LYM14 3 12521. 1 A 91.3 89 8.93E- 01 0.4 LYM15 11611. 3 F 0.44 6 2.37E- 01 37.3 LYM30 11913. 3 A 91.2 04 8.94E- 01 0.2 LYM13 11771. 6 F 0.35 5 2.37E- 01 9.2 LYM11 9 12461. 1 A 91.1 51 9.05E- 01 0.1 LYM19 11751. 5 F 0.39 6 2.37E- 01 21.9 LYM57 12012. 4 A 91.4 74 9.22E- 01 0.5 LYM11 3 12442. 1 F 0.40 7 2.56E- 01 25.4 LYM25 4 12474. 3 A 91.2 98 9.38E- 01 0.3 LYM13 8 12564. 1 F 0.35 5 2.62E- 01 9.4 LYM14 12052. 4 A 91.1 21 9.52E- 01 0.1 LYM15 11614. 4 F 0.35 8 2.72E- 01 10.1 LYM62 12023. 4 A 91.1 12 9.60E- 01 0.1 LYM13 0 12332. 2 F 0.48 1 2.74E- 01 48 LYM66 11952. 1 A 91.0 69 9.64E- 01 0 LYM1 11601. 1 F 0.40 3 2.92E- 01 24.1 LYM43 11793. 2 A 91.0 6 9.73E- 01 0 LYM14 0 12261. 4 F 0.35 9 2.93E- 01 10.6 LYM11 1 12254. 3 A 91.0 41 9.81E- 01 0 LYM10 2 12222. 3 F 0.45 1 2.97E- 01 38.8 LYM13 0 12332. 2 A 91.0 95 9.83E- 01 0.1 LYM10 11742. 1 F 0.39 4 3.00E- 01 21.1 LYM15 2 12376. 1 A 91.0 52 9.90E- 01 0 LYM13 4 12311. 2 F 0.40 1 3.03E- 01 23.4 CONTR OL _ A 91.0 24 _ 0 LYM14 8 12174. 2 F 0.34 9 3.05E- 01 7.4 LYM69 11853. 5 B 0.38 2 7.33E- 03 13.4 LYM17 4 12414. 2 F 0.39 3 3.10E- 01 20.9 LYM53 11841. 2 B 0.40 7 1.01E- 02 20.8 LYM28 9 12493. 6 F 0.38 3.17E- 01 17.1 LYM13 8 12561. 1 B 0.41 8 1.55E- 02 24 LYM22 11762. 1 F 0.36 1 3.24E- 01 11.2 LYM13 4 12314. 2 B 0.36 6 5.15E- 02 8.8 LYM17 4 12412. 1 F 0.42 5 3.25E- 01 30.9 LYM14 0 12264. 1 B 0.36 2 7.22E- 02 7.5 LYM21 11671. 2 F 0.39 3 3.28E- 01 21 LYM11 9 12461. 1 B 0.39 7 1.11E- 01 17.8 LYM11 1 12251. 1 F 0.39 5 3.31E- 01 21.4 LYM30 11913. 5 B 0.35 6 1.56E- 01 5.6 LYM17 11684. 5 F 0.34 7 3.33E- 01 6.9 LYM53 11844. 2 B 0.37 7 1.57E- 01 11.9 LYM9 11633. 7 F 0.40 6 3.55E- 01 25 LYM51 11894. 2 B 0.35 8 1.63E- 01 6.3 2016213786 11 Aug 2016 298 Gene name Event I D Mea n P value % incr. vs. cont. Gene name Event I D Mea n P value % incr. vs. cont. LYM11 1 12254. 4 F 0.34 6 3.64E- 01 6.5 LYM51 11891. 1 B 0.35 8 1.64E- 01 6.2 LYM14 3 12524. 2 F 0.35 2 3.68E- 01 8.3 LYM10 0 12131. 2 B 0.36 1 1.82E- 01 7.3 LYM10 6 12142. 2 F 0.35 1 3.69E- 01 8.1 LYM53 11841. 1 B 0.36 1 1.82E- 01 7.3 LYM15 11614. 3 F 0.42 7 3.69E- 01 31.5 LYM11 1 12251. 3 B 0.39 8 2.06E- 01 18.2 LYM10 11744. 5 F 0.35 3 3.79E- 01 8.6 LYM14 3 12524. 2 B 0.44 6 2.56E- 01 32.3 LYM11 9 12462. 1 F 0.49 3.83E- 01 50.8 LYM57 12013. 5 B 0.38 3 2.62E- 01 13.6 LYM17 4 12411. 2 F 0.39 3 3.90E- 01 20.8 LYM13 8 12561. 3 B 0.38 1 2.70E- 01 13.2 LYM26 8 12483. 2 F 0.42 7 3.97E- 01 31.4 LYM11 1 12252. 2 B 0.36 8 2.79E- 01 9.1 LYM17 11684. 4 F 0.37 9 4.02E- 01 16.6 LYM17 2 12301. 2 B 0.35 3.03E- 01 3.9 LYM13 11771. 9 F 0.39 2 4.05E- 01 20.7 LYM13 8 12562. 1 B 0.35 7 3.98E- 01 6 LYM28 9 12491. 1 F 0.43 4.12E- 01 32.5 LYM26 8 12482. 3 B 0.35 9 4.07E- 01 6.7 LYM29 0 12502. 4 F 0.34 5 4.15E- 01 6.3 LYM51 11893. 2 B 0.34 8 4.13E- 01 3.4 LYM17 11682. 1 F 0.41 4.20E- 01 26.2 LYM10 5 12295. 2 B 0.36 7 4.31E- 01 8.9 LYM14 8 12172. 1 F 0.36 9 4.31E- 01 13.6 LYM10 5 12293. 1 B 0.36 4.56E- 01 6.9 LYM10 5 12294. 2 F 0.38 9 4.33E- 01 19.8 LYM29 0 12502. 4 B 0.35 1 4.58E- 01 4.3 LYM2 11695. 3 F 0.35 1 4.55E- 01 7.9 LYM26 8 12483. 2 B 0.37 3 4.72E- 01 10.8 LYM10 2 12222. 6 F 0.37 1 4.65E- 01 14.2 LYM14 3 12521. 2 B 0.37 8 5.08E- 01 12.1 LYM15 11612. 3 F 0.38 5 4.85E- 01 18.5 LYM62 12021. 1 B 0.36 8 5.10E- 01 9.3 LYM14 3 12521. 1 F 0.35 3 4.93E- 01 8.6 LYM68 11941. 4 B 0.40 8 5.11E- 01 21.2 LYM29 0 12501. 3 F 0.39 9 5.13E- 01 22.9 LYM29 0 12501. 3 B 0.36 1 5.13E- 01 7.3 LYM15 3 12321. 2 F 0.38 8 5.47E- 01 19.4 LYM14 8 12174. 2 B 0.34 7 5.34E- 01 3 LYM17 11683. 1 F 0.33 8 5.62E- 01 4 LYM31 11923. 4 B 0.35 1 5.39E- 01 4.3 LYM26 8 12483. 4 F 0.36 1 5.88E- 01 11.1 LYM14 12052. 5 B 0.34 6 5.46E- 01 2.8 LYM10 2 12221. 1 F 0.34 8 5.96E- 01 7.2 LYM11 1 12254. 4 B 0.34 6 5.71E- 01 2.8 LYM2 11693. 3 F 0.36 8 6.14E- 01 13.1 LYM51 11893. 4 B 0.34 9 5.77E- 01 3.7 LYM13 8 12562. 1 F 0.36 1 6.15E- 01 11.1 LYM13 7 12153. 1 B 0.37 8 5.84E- 01 12.3 2016213786 11 Aug 2016 299 Gene name Event I D Mea n P value % incr. vs. cont. Gene name Event I D Mea n P value % incr. vs. cont. LYM21 11672. 4 F 0.34 7 6.16E- 01 6.8 LYM13 2 12271. 4 B 0.34 6 5.95E- 01 2.8 LYM13 11773. 2 F 0.33 8 6.25E- 01 4 LYM13 8 12564. 1 B 0.34 6 6.18E- 01 2.8 LYM13 2 12275. 3 F 0.37 6.32E- 01 13.9 LYM30 11913. 3 B 0.38 8 6.38E- 01 15.2 LYM13 0 12331. 3 F 0.35 8 6.50E- 01 10.2 LYM13 7 12152. 1 B 0.34 4 6.57E- 01 2.3 LYM14 8 12173. 1 F 0.37 8 6.57E- 01 16.3 LYM14 12052. 4 B 0.34 6 6.71E- 01 2.6 LYM3 12041. 2 F 0.34 3 6.88E- 01 5.7 LYM11 9 12462. 2 B 0.34 3 6.92E- 01 1.9 LYM13 7 12151. 1 F 0.34 2 6.98E- 01 5.3 LYM25 4 12474. 4 B 0.35 6.93E- 01 3.9 LYM10 6 12141. 4 F 0.34 9 7.07E- 01 7.4 LYM43 11791. 5 B 0.34 1 7.48E- 01 1.3 LYM14 1 12404. 2 F 0.34 6 7.13E- 01 6.6 LYM62 12022. 1 B 0.35 7 7.54E- 01 6 LYM14 3 12521. 2 F 0.33 7 7.26E- 01 3.6 LYM53 11842. 4 B 0.35 8 7.57E- 01 6.3 LYM10 5 12294. 3 F 0.35 3 7.73E- 01 8.6 LYM10 5 12297. 1 B 0.35 9 7.60E- 01 6.7 LYM10 0 12131. 3 F 0.34 5 8.18E- 01 6 LYM16 2 12231. 3 B 0.36 1 7.67E- 01 7.3 LYM9 11633. 2 F 0.34 8.64E- 01 4.6 LYM13 7 12151. 1 B 0.34 1 7.73E- 01 1.3 LYM11 1 12252. 2 F 0.34 8.78E- 01 4.8 LYM57 12013. 3 B 0.36 2 7.76E- 01 7.5 LYM26 8 12482. 1 F 0.33 8.79E- 01 1.6 LYM68 11941. 3 B 0.35 7 7.84E- 01 6 LYM11 3 12444. 4 F 0.32 8 9.04E- 01 0.8 LYM17 2 12301. 3 B 0.34 9 8.04E- 01 3.7 LYM16 2 12233. 2 F 0.32 7 9.42E- 01 0.5 LYM14 8 12174. 1 B 0.34 7 8.07E- 01 3 LYM10 2 12222. 1 F 0.32 8 9.74E- 01 0.9 LYM51 11892. 1 B 0.34 4 8.21E- 01 2.3 LYM15 3 12324. 1 F 0.32 7 9.76E- 01 0.5 LYM53 11843. 2 B 0.35 2 8.35E- 01 4.4 LYM10 6 12144. 4 F 0.32 6 9.76E- 01 0.3 LYM26 8 12481. 1 B 0.33 9 8.37E- 01 0.8 CONTR OL _ F 0.32 5 _ 0 LYM13 7 12151. 2 B 0.34 1 8.42E- 01 1.3 LYM19 11752. 2 G 9.40 2 2.33E- 04 43.1 LYM68 11942. 3 B 0.34 3 8.62E- 01 1.9 LYM14 3 12524. 7 G 8.84 9 3.23E- 04 34.7 LYM29 0 12502. 1 B 0.33 9 8.75E- 01 0.6 LYM13 2 12275. 3 G 8.76 7 4.00E- 04 33.4 LYM13 4 12313. 2 B 0.33 9 8.82E- 01 0.6 LYM15 11614. 4 G 8.72 9 4.28E- 04 32.9 LYM30 11913. 4 B 0.35 5 8.85E- 01 5.5 LYM4 11705. 2 G 8.61 6 5.60E- 04 31.2 LYM15 2 12373. 2 B 0.34 5 8.86E- 01 2.4 2016213786 11 Aug 2016 300 Gene name Event I D Mea n P value % incr. vs. cont. Gene name Event I D Mea n P value % incr. vs. cont. LYM9 11632. 1 G 8.60 5 6.15E- 04 31 LYM31 11922. 3 B 0.34 4 9.08E- 01 2.3 LYM13 11772. 2 G 8.53 1 7.47E- 04 29.8 LYM69 11852. 2 B 0.34 3 9.23E- 01 1.9 LYM17 4 12414. 3 G 8.46 5 9.60E- 04 28.8 LYM67 11781. 5 B 0.34 9.46E- 01 1 LYM13 2 12273. 2 G 8.48 1 1.28E- 03 29.1 LYM15 2 12372. 1 B 0.33 9 9.51E- 01 0.6 LYM10 5 12294. 3 G 8.32 1.52E- 03 26.6 LYM57 12012. 6 B 0.33 8 9.53E- 01 0.2 LYM13 8 12561. 1 G 8.22 5 2.11E- 03 25.2 LYM13 7 12154. 5 B 0.33 8 9.64E- 01 0.4 LYM19 11754. 1 G 8.14 3 2.69E- 03 23.9 LYM17 2 12304. 2 B 0.34 1 9.64E- 01 1.3 LYM11 3 12444. 5 G 8.01 5 4.33E- 03 22 LYM57 12012. 2 B 0.33 8 9.71E- 01 0.2 LYM11 1 12252. 2 G 7.97 2 5.09E- 03 21.3 LYM26 8 12482. 1 B 0.33 8 9.86E- 01 0.2 LYM15 3 12324. 1 G 8.02 2 6.24E- 03 22.1 LYM67 11783. 5 B 0.33 7 9.93E- 01 0.1 LYM13 0 12334. 1 G 8.04 6 6.78E- 03 22.5 CONTR OL _ B 0.33 7 _ 0 LYM17 4 12411. 3 G 8.77 2 1.45E- 02 33.5 LYM13 7 12152. 1 C 4.38 8 2.02E- 02 15.2 LYM17 11683. 1 G 7.67 9 1.61E- 02 16.9 LYM53 11844. 2 C 4.37 5 2.89E- 02 14.9 LYM13 0 12331. 3 G 7.68 4 1.97E- 02 17 LYM11 1 12251. 3 C 4.3 4.04E- 02 12.9 LYM15 11611. 3 G 7.85 2.01E- 02 19.5 LYM51 11894. 2 C 4.27 5 4.70E- 02 12.3 LYM10 11742. 1 G 8.12 7 2.10E- 02 23.7 LYM14 8 12174. 2 C 4.32 5 5.44E- 02 13.6 LYM17 11682. 1 G 7.60 4 2.15E- 02 15.7 LYM13 8 12561. 1 C 4.3 6.41E- 02 12.9 LYM11 1 12254. 4 G 7.60 1 2.17E- 02 15.7 LYM11 1 12252. 2 C 4.22 5 6.83E- 02 11 LYM15 3 12321. 2 G 8.37 4 2.39E- 02 27.5 LYM11 9 12461. 1 C 4.21 5 8.43E- 02 10.7 LYM11 3 12443. 1 G 7.57 4 2.47E- 02 15.3 LYM11 1 12254. 4 C 4.18 1 1.22E- 01 9.8 LYM10 0 12134. 1 G 7.56 2 2.55E- 02 15.1 LYM53 11841. 1 C 4.25 1.46E- 01 11.6 LYM28 9 12493. 2 G 8.63 3.01E- 02 31.4 LYM29 0 12501. 3 C 4.16 9 1.58E- 01 9.5 LYM22 11764. 7 G 7.56 6 3.04E- 02 15.2 LYM13 7 12153. 1 C 4.64 1 1.63E- 01 21.9 LYM13 0 12332. 1 G 7.50 5 3.23E- 02 14.2 LYM14 3 12524. 2 C 4.31 3 1.76E- 01 13.3 LYM1 11601. 1 G 9.44 5 3.25E- 02 43.8 LYM13 7 12154. 5 C 4.10 6 1.78E- 01 7.9 LYM15 3 12322. 1 G 7.46 2 3.90E- 02 13.6 LYM13 4 12314. 2 C 4.34 4 1.83E- 01 14.1 2016213786 11 Aug 2016 301 Gene name Event I D Mea n P value % incr. vs. cont. Gene name Event I D Mea n P value % incr. vs. cont. LYM10 0 12133. 1 G 7.94 8 4.23E- 02 21 LYM13 8 12564. 1 C 4.19 4 2.80E- 01 10.2 LYM10 2 12221. 1 G 7.44 4 4.24E- 02 13.3 LYM25 4 12474. 4 c 4.13 8 2.93E- 01 8.7 LYM14 0 12261. 4 G 7.46 4.52E- 02 13.5 LYM11 9 12462. 2 c 4.13 1 3.11E- 01 8.5 LYM22 11761. 3 G 7.41 8 4.69E- 02 12.9 LYM51 11893. 2 c 4.16 9 3.79E- 01 9.5 LYM10 5 12293. 1 G 7.40 4 5.03E- 02 12.7 LYM69 11853. 5 c 3.98 8 3.90E- 01 4.7 LYM13 2 12271. 4 G 8.77 8 5.13E- 02 33.6 LYM14 0 12264. 1 c 4.11 3 4.20E- 01 8 LYM13 2 12275. 1 G 7.73 7 5.17E- 02 17.8 LYM10 5 12297. 1 c 3.98 1 4.86E- 01 4.6 LYM13 4 12312. 3 G 8.64 6 5.27E- 02 31.6 LYM51 11893. 4 c 4.24 4 5.14E- 01 11.5 LYM16 2 12234. 4 G 7.46 1 5.37E- 02 13.6 LYM13 8 12561. 3 c 4.28 1 5.21E- 01 12.4 LYM19 11753. 1 G 7.79 3 6.24E- 02 18.6 LYM68 11941. 4 c 4.12 3 5.24E- 01 8.3 LYM28 9 12493. 6 G 8.21 8 6.32E- 02 25.1 LYM13 4 12312. 4 c 3.95 6 6.33E- 01 3.9 LYM13 8 12566. 1 G 7.34 9 8.04E- 02 11.9 LYM13 8 12562. 1 c 3.91 3 6.53E- 01 2.8 LYM3 12042. 1 G 8.32 8 8.35E- 02 26.8 LYM53 11843. 2 c 3.97 5 6.64E- 01 4.4 LYM13 4 12314. 2 G 8.44 2 8.52E- 02 28.5 LYM53 11841. 2 c 4.02 6.89E- 01 5.6 LYM21 11674. 5 G 7.26 1 9.00E- 02 10.5 LYM11 1 12251. 1 c 3.99 4 7.37E- 01 4.9 LYM15 2 12371. 3 G 7.55 4 9.80E- 02 15 LYM25 4 12472. 3 c 3.98 8 7.61E- 01 4.7 LYM13 4 12311. 2 G 7.53 9 1.05E- 01 14.7 LYM26 11824. 1 c 3.96 9 7.64E- 01 4.2 LYM11 1 12251. 1 G 7.51 2 1.05E- 01 14.3 LYM17 2 12304. 1 c 3.86 4 7.87E- 01 1.5 LYM10 6 12144. 4 G 7.54 1.07E- 01 14.8 LYM14 0 12261. 1 c 3.85 6 8.15E- 01 1.3 LYM28 9 12491. 4 G 7.44 2 1.1 OE-01 13.3 LYM51 11891. 1 c 3.85 8.33E- 01 1.1 LYM13 11773. 2 G 7.78 1.11E- 01 18.4 LYM51 11892. 1 c 3.85 6 8.47E- 01 1.3 LYM16 11624. 4 G 7.50 4 1.12E- 01 14.2 LYM13 7 12151. 2 c 3.88 1 8.63E- 01 1.9 LYM16 2 12233. 2 G 7.20 5 1.15E- 01 9.7 LYM13 7 12151. 1 c 3.89 4 8.70E- 01 2.3 LYM10 6 12144. 3 G 8.29 8 1.25E- 01 26.3 LYM11 9 12462. 1 c 3.83 1 9.06E- 01 0.6 LYM3 12041. 2 G 7.35 1 1.34E- 01 11.9 LYM26 11824. 5 c 3.83 1 9.06E- 01 0.6 LYM13 8 12562. 1 G 7.15 6 1.44E- 01 8.9 LYM57 12013. 3 c 3.88 9.10E- 01 1.9 2016213786 11 Aug 2016 302 Gene name Event I D Mea n P value % incr. vs. cont. Gene name Event I D Mea n P value % incr. vs. cont. LYM13 7 12153. 1 G 8.56 5 1.46E- 01 30.4 LYM29 0 12504. 1 C 3.85 6 9.32E- 01 1.3 LYM11 3 12442. 2 G 7.70 3 1.48E- 01 17.3 LYM25 4 12474. 3 c 3.82 5 9.39E- 01 0.5 LYM17 11681. 4 G 7.50 6 1.49E- 01 14.3 LYM10 0 12131. 2 c 3.81 9 9.68E- 01 0.3 LYM10 2 12222. 2 G 7.66 1 1.59E- 01 16.6 LYM66 11954. 5 c 3.81 3 9.80E- 01 0.1 LYM13 0 12333. 1 G 7.53 8 1.65E- 01 14.7 LYM57 12012. 6 c 3.81 3 9.80E- 01 0.1 LYM11 3 12442. 1 G 8.27 7 1.67E- 01 26 CONTR OL _ c 3.80 7 _ 0 LYM10 5 12294. 2 G 7.50 4 1.68E- 01 14.2 LYM13 4 12314. 2 D 0.47 4 2.43E- 04 37.7 LYM10 11742. 2 G 8.76 4 1.69E- 01 33.4 LYM26 8 12482. 3 D 0.45 2 7.22E- 04 31.3 LYM14 1 12404. 4 G 8.02 8 1.72E- 01 22.2 LYM31 11923. 4 D 0.44 2 1.43E- 03 28.3 LYM14 0 12261. 1 G 8.77 1.78E- 01 33.5 LYM13 8 12561. 1 D 0.49 4.94E- 03 42.3 LYM1 11602. 1 G 7.47 4 1.80E- 01 13.8 LYM17 0 12453. 2 D 0.43 7.39E- 03 24.9 LYM16 2 12231. 3 G 7.51 2 1.84E- 01 14.3 LYM14 8 12171. 2 D 0.43 5 8.04E- 03 26.3 LYM10 2 12222. 3 G 7.90 6 1.85E- 01 20.3 LYM57 12013. 5 D 0.41 4 1.08E- 02 20.3 LYM10 0 12131. 2 G 7.78 3 1.88E- 01 18.5 LYM68 11942. 3 D 0.43 1 1.45E- 02 25.2 LYM14 1 12404. 1 G 7.44 3 1.92E- 01 13.3 LYM43 11791. 5 D 0.47 1 1.54E- 02 36.6 LYM13 11772. 1 G 7.64 3 1.99E- 01 16.3 LYM14 0 12264. 1 D 0.40 8 1.74E- 02 18.5 LYM1 11602. 6 G 7.44 3 1.99E- 01 13.3 LYM10 0 12131. 2 D 0.49 5 4.32E- 02 43.5 LYM4 11706. 3 G 7.16 6 2.00E- 01 9.1 LYM13 7 12152. 1 D 0.39 4.90E- 02 13.2 LYM15 3 12323. 2 G 7.96 8 2.11E- 01 21.3 LYM57 12012. 2 D 0.39 5.17E- 02 13.1 LYM2 11695. 3 G 7.81 9 2.19E- 01 19 LYM69 11853. 5 D 0.42 8 6.11E- 02 24.3 LYM3 12043. 1 G 8.85 6 2.24E- 01 34.8 LYM14 12052. 4 D 0.38 7 6.34E- 02 12.5 LYM13 11771. 9 G 8.78 2 2.27E- 01 33.7 LYM14 3 12524. 2 D 0.45 9 6.71E- 02 33.1 LYM28 9 12492. 2 G 7.52 1 2.28E- 01 14.5 LYM53 11841. 1 D 0.46 2 7.65E- 02 34.1 LYM16 2 12231. 1 G 7.97 6 2.31E- 01 21.4 LYM14 8 12174. 1 D 0.53 7 8.03E- 02 55.9 LYM11 3 12444. 4 G 8.06 6 2.38E- 01 22.8 LYM29 0 12502. 4 D 0.44 4 8.80E- 02 28.8 LYM13 0 12332. 2 G 8.4 2.46E- 01 27.9 LYM10 5 12294. 3 D 0.40 1 9.08E- 02 16.3 2016213786 11 Aug 2016 303 Gene name Event I D Mea n P value % incr. vs. cont. Gene name Event I D Mea n P value % incr. vs. cont. LYM10 11744. 5 G 7.02 5 2.46E- 01 6.9 LYM11 9 12462. 1 D 0.50 1 1.14E- 01 45.4 LYM17 4 12412. 1 G 8.37 2.55E- 01 27.4 LYM68 11941. 3 D 0.42 9 1.18E- 01 24.5 LYM9 11632. 2 G 7.50 5 2.64E- 01 14.2 LYM57 12012. 6 D 0.37 5 1.65E- 01 8.9 LYM10 0 12133. 3 G 7.44 4 2.66E- 01 13.3 LYM13 7 12151. 1 D 0.42 7 1.68E- 01 23.9 LYM15 2 12372. 2 G 7.52 2.67E- 01 14.5 LYM30 11913. 5 D 0.41 1 1.70E- 01 19.2 LYM11 9 12461. 4 G 8.26 4 2.68E- 01 25.8 LYM43 11791. 4 D 0.41 7 1.74E- 01 21.1 LYM14 0 12262. 3 G 8.23 2 2.72E- 01 25.3 LYM11 1 12252. 2 D 0.65 8 1.79E- 01 90.8 LYM14 0 12264. 1 G 8.75 3 2.84E- 01 33.2 LYM13 8 12561. 3 D 0.45 2 2.37E- 01 31.3 LYM14 8 12172. 1 G 8.29 5 2.85E- 01 26.3 LYM15 2 12372. 2 D 0.38 1 2.51E- 01 10.5 LYM13 8 12564. 1 G 7.27 2.88E- 01 10.7 LYM11 9 12462. 2 D 0.41 7 2.52E- 01 21.1 LYM14 3 12521. 1 G 7.43 3 2.89E- 01 13.1 LYM11 1 12254. 4 D 0.39 5 2.69E- 01 14.7 LYM4 11706. 5 G 7.38 1 2.90E- 01 12.4 LYM13 7 12154. 5 D 0.40 8 2.69E- 01 18.3 LYM10 6 12141. 4 G 7.83 6 2.92E- 01 19.3 LYM11 1 12251. 3 D 0.4 3.04E- 01 16 LYM10 2 12222. 6 G 7.60 8 2.95E- 01 15.8 LYM30 11912. 6 D 0.42 4 3.16E- 01 22.9 LYM2 11693. 3 G 7.68 3.07E- 01 16.9 LYM62 12021. 1 D 0.42 3.20E- 01 22 LYM10 6 12142. 2 G 8.08 5 3.09E- 01 23.1 LYM26 8 12481. 1 D 0.39 5 3.24E- 01 14.6 LYM11 9 12461. 1 G 8.06 1 3.13E- 01 22.7 LYM43 11792. 2 D 0.38 6 3.28E- 01 12 LYM14 8 12174. 2 G 7.99 7 3.17E- 01 21.7 LYM13 0 12331. 3 D 0.36 4 3.67E- 01 5.8 LYM10 5 12297. 1 G 7.58 9 3.25E- 01 15.5 LYM13 7 12153. 1 D 0.39 4 3.68E- 01 14.4 LYM10 11744. 1 G 8.49 4 3.37E- 01 29.3 LYM68 11942. 2 D 0.38 2 3.96E- 01 11 LYM29 0 12501. 3 G 8.09 8 3.38E- 01 23.3 LYM68 11943. 2 D 0.40 6 4.05E- 01 17.7 LYM2 11695. 1 G 7.38 2 3.44E- 01 12.4 LYM17 2 12301. 2 D 0.41 2 4.21E- 01 19.4 LYM9 11633. 7 G 7.29 6 3.48E- 01 11.1 LYM53 11844. 2 D 0.41 4 4.32E- 01 20.1 LYM17 4 12414. 2 G 7.92 2 3.51E- 01 20.6 LYM51 11893. 4 D 0.45 4.63E- 01 30.7 LYM13 11771. 6 G 7.03 5 3.52E- 01 7.1 LYM11 9 12461. 1 D 0.48 6 4.65E- 01 41 LYM3 12041. 1 G 8.12 9 3.75E- 01 23.7 LYM10 5 12295. 2 D 0.37 9 4.68E- 01 10 2016213786 11 Aug 2016 304 Gene name Event I D Mea n P value % incr. vs. cont. Gene name Event I D Mea n P value % incr. vs. cont. LYM19 11751. 5 G 7.91 1 3.82E- 01 20.4 LYM51 11893. 2 D 0.36 8 4.81E- 01 6.8 LYM15 11614. 3 G 7.80 7 3.82E- 01 18.8 LYM15 2 12376. 1 D 0.39 4 4.85E- 01 14.5 LYM1 11604. 4 G 7.12 2 3.96E- 01 8.4 LYM13 4 12312. 4 D 0.36 9 4.91E- 01 7.2 LYM13 7 12152. 1 G 8.26 1 4.00E- 01 25.7 LYM51 11894. 2 D 0.36 5.02E- 01 4.4 LYM21 11674. 1 G 6.88 2 4.03E- 01 4.8 LYM15 2 12372. 1 D 0.43 5.13E- 01 24.8 LYM13 7 12151. 1 G 7.90 1 4.07E- 01 20.3 LYM62 12022. 1 D 0.37 3 5.37E- 01 8.1 LYM16 2 12234. 3 G 8.00 4 4.22E- 01 21.8 LYM11 1 12254. 3 D 0.44 6 5.43E- 01 29.5 LYM13 8 12561. 3 G 6.87 4.25E- 01 4.6 LYM10 0 12131. 3 D 0.35 7 5.49E- 01 3.5 LYM28 9 12491. 1 G 7.20 2 4.30E- 01 9.6 LYM14 3 12524. 7 D 0.45 5.61E- 01 30.6 LYM12 9 12573. 5 G 7.19 8 4.45E- 01 9.6 LYM29 0 12502. 2 D 0.40 1 5.62E- 01 16.4 LYM13 2 12276. 1 G 7.23 2 4.45E- 01 10.1 LYM14 12051. 4 D 0.36 5 5.63E- 01 6 LYM10 11741. 2 G 7.63 3 4.60E- 01 16.2 LYM67 11783. 5 D 0.38 6 6.06E- 01 12 LYM2 11691. 2 G 7.39 6 4.69E- 01 12.6 LYM43 11793. 2 D 0.37 5 6.13E- 01 8.9 LYM17 11684. 5 G 7.52 7 4.73E- 01 14.6 LYM30 11912. 7 D 0.35 9 6.25E- 01 4.1 LYM11 1 12254. 3 G 7.47 4 4.74E- 01 13.8 LYM10 0 12133. 3 D 0.35 6 6.28E- 01 3.4 LYM15 3 12324. 2 G 7.35 1 4.78E- 01 11.9 LYM11 9 12461. 4 D 0.37 6 6.48E- 01 9.1 LYM17 11684. 4 G 7.29 4.79E- 01 11 LYM68 11941. 4 D 0.35 3 6.66E- 01 2.5 LYM11 9 12462. 2 G 6.94 1 4.86E- 01 5.6 LYM10 0 12134. 1 D 0.36 3 6.77E- 01 5.5 LYM15 2 12371. 2 G 7.56 5 4.94E- 01 15.2 LYM29 0 12501. 3 D 0.36 2 7.05E- 01 5.2 LYM16 11623. 5 G 7.01 1 4.96E- 01 6.7 LYM95 12124. 4 D 0.35 2 7.39E- 01 2.1 LYM14 1 12404. 3 G 7.03 6 5.07E- 01 7.1 LYM26 11824. 6 D 0.36 2 7.57E- 01 5 LYM21 11673. 1 G 8.61 7 5.09E- 01 31.2 LYM14 3 12521. 2 D 0.35 1 7.58E- 01 1.8 LYM10 6 12142. 1 G 7.44 8 5.21E- 01 13.4 LYM13 8 12562. 1 D 0.36 3 7.64E- 01 5.3 LYM21 11671. 2 G 9.05 8 5.24E- 01 37.9 LYM13 2 12275. 1 D 0.35 1 7.77E- 01 2 LYM3 12043. 2 G 8.68 8 5.30E- 01 32.2 LYM13 2 12276. 1 D 0.35 2 7.92E- 01 2.1 LYM14 1 12402. 4 G 7.38 4 5.30E- 01 12.4 LYM25 4 12474. 4 D 0.37 5 7.96E- 01 9 2016213786 11 Aug 2016 305 Gene name Event I D Mea n P value % incr. vs. cont. Gene name Event I D Mea n P value % incr. vs. cont. LYM11 3 12441. 4 G 7.04 9 5.31E- 01 13 LYM13 2 12271. 4 D 0.35 6 8.08E- 01 3.4 LYM10 2 12222. 1 G 7.91 7 5.33E- 01 20.5 LYM13 0 12332. 2 D 0.35 7 8.15E- 01 3.6 LYM26 8 12483. 2 G 7.79 4 5.34E- 01 18.6 LYM67 11782. 4 D 0.35 6 8.23E- 01 3.2 LYM22 11762. 1 G 7.80 1 5.39E- 01 18.7 LYM53 11842. 4 D 0.36 2 8.38E- 01 5.2 LYM11 9 12462. 1 G 7.69 2 5.48E- 01 17.1 LYM51 11891. 1 D 0.34 8 8.52E- 01 1.1 LYM15 11612. 3 G 7.17 5 5.52E- 01 9.2 LYM14 8 12173. 1 D 0.34 8 9.01E- 01 1 LYM10 0 12131. 3 G 7.14 5 5.60E- 01 8.8 LYM15 2 12373. 1 D 0.35 3 9.14E- 01 2.6 LYM14 3 12523. 4 G 7.04 6 5.67E- 01 7.2 LYM16 2 12231. 3 D 0.34 9 9.41E- 01 1.3 LYM14 8 12174. 1 G 7.40 3 5.77E- 01 12.7 LYM26 8 12482. 1 D 0.35 9.52E- 01 1.7 LYM19 11751. 4 G 7.08 4 5.88E- 01 7.8 LYM66 11954. 4 D 0.34 5 9.97E- 01 0.1 LYM14 3 12521. 2 G 6.96 2 6.60E- 01 6 CONTR OL _ D 0.34 5 _ 0 LYM11 1 12251. 3 G 6.83 2 6.96E- 01 4 LYM11 1 12252. 2 E 9.68 8 7.00E- 06 21.3 LYM15 11612. 2 G 6.95 6 6.97E- 01 5.9 LYM53 11841. 1 E 9.06 3 1.80E- 04 13.5 LYM16 11623. 2 G 7.05 7.01E- 01 7.3 LYM57 12013. 5 E 9 2.83E- 04 12.7 LYM10 5 12297. 2 G 6.78 9 7.14E- 01 3.3 LYM10 5 12297. 1 E 8.87 5 6.26E- 04 11.2 LYM11 9 12463. 2 G 6.81 3 7.50E- 01 3.7 LYM13 8 12561. 1 E 9.5 7.87E- 04 19 LYM13 7 12151. 2 G 6.99 2 7.65E- 01 6.4 LYM10 0 12131. 2 E 8.81 3 1.02E- 03 10.4 LYM26 8 12483. 4 G 6.84 4 7.81E- 01 4.2 LYM14 8 12174. 1 E 9.25 1.72E- 03 15.9 LYM26 8 12482. 1 G 6.75 5 8.29E- 01 2.8 LYM69 11853. 5 E 9.25 1.72E- 03 15.9 LYM9 11633. 2 G 6.80 3 8.47E- 01 3.5 LYM14 3 12524. 2 E 8.68 8 2.72E- 03 8.8 LYM14 1 12404. 2 G 6.78 6 8.53E- 01 3.3 LYM30 11913. 5 E 8.68 8 2.72E- 03 8.8 LYM29 0 12502. 4 G 6.64 1 8.59E- 01 1.1 LYM30 11913. 4 E 8.59 8 4.80E- 03 7.7 LYM21 11672. 4 G 6.67 8.97E- 01 1.5 LYM43 11791. 4 E 8.56 3 7.93E- 03 7.2 LYM12 9 12572. 2 G 6.61 6 9.20E- 01 0.7 LYM67 11783. 5 E 8.74 1 1.00E- 02 9.5 LYM13 4 12312. 4 G 6.75 9 9.21E- 01 2.9 LYM14 0 12264. 1 E 8.5 1.16E- 02 6.5 LYM22 11764. 1 G 6.64 8 9.44E- 01 1.2 LYM14 3 12521. 2 E 8.5 1.16E- 02 6.5 2016213786 11 Aug 2016 306 Gene name Event I D Mea n P value % incr. vs. cont. Gene name Event I D Mea n P value % incr. vs. cont. LYM29 0 12502. 2 G 6.60 7 9.83E- 01 0.6 LYM43 11791. 5 E 8.75 1.31E- 02 9.6 LYM14 8 12173. 1 G 6.58 2 9.90E- 01 0.2 LYM68 11941. 3 E 8.75 1.31E- 02 9.6 CONTR OL _ G 6.57 _ 0 LYM68 11942. 3 E 9.31 3 1.72E- 02 16.6 LYM14 3 12524. 7 H 16.0 67 1.30E- 05 63.3 LYM11 9 12461. 1 E 9.18 8 2.19E- 02 15.1 LYM14 8 12171. 2 H 16.1 14 1.80E- 05 63.8 LYM14 3 12524. 7 E 9.18 8 2.19E- 02 15.1 LYM13 0 12333. 1 H 14.8 09 6.50E- 05 50.5 LYM51 11894. 2 E 8.43 8 2.49E- 02 5.7 LYM10 11741. 2 H 18.7 1 9.40E- 05 90.1 LYM95 12124. 4 E 8.43 8 2.49E- 02 5.7 LYM4 11706. 5 H 14.0 74 2.31E- 04 43 LYM51 11893. 2 E 9.06 3 2.84E- 02 13.5 LYM10 2 12222. 2 H 14.0 87 2.46E- 04 43.2 LYM30 11913. 3 E 8.93 8 3.78E- 02 11.9 LYM1 11602. 1 H 13.9 72 2.52E- 04 42 LYM14 12052. 4 E 8.5 5.02E- 02 6.5 LYM10 5 12293. 1 H 13.8 79 3.34E- 04 41 LYM29 0 12502. 2 E 8.5 5.02E- 02 6.5 LYM10 11744. 1 H 13.8 5 3.39E- 04 40.8 LYM13 4 12314. 2 E 8.81 3 5.19E- 02 10.4 LYM16 2 12234. 3 H 13.5 67 4.59E- 04 37.9 LYM10 5 12294. 2 E 8.31 3 8.12E- 02 4.1 LYM14 0 12262. 3 H 12.9 58 1.39E- 03 31.7 LYM13 0 12332. 2 E 8.87 5 1.03E- 01 11.2 LYM15 11614. 3 H 12.8 9 1.69E- 03 31 LYM13 7 12153. 1 E 8.26 8 1.05E- 01 3.6 LYM15 2 12372. 2 H 13.5 17 5.83E- 03 37.4 LYM16 2 12234. 3 E 8.37 5 1.08E- 01 4.9 LYM11 9 12461. 4 H 12.4 16 7.53E- 03 26.2 LYM29 0 12501. 3 E 8.37 5 1.08E- 01 4.9 LYM1 11602. 6 H 19.4 77 7.70E- 03 97.9 LYM62 12022. 1 E 8.37 5 1.08E- 01 4.9 LYM13 2 12273. 2 H 12.9 17 1.21E- 02 31.3 LYM11 9 12462. 2 E 8.56 3 1.10E-01 7.2 LYM13 0 12334. 1 H 13.0 43 1.44E- 02 32.5 LYM17 2 12302. 2 E 8.56 3 1.10E-01 7.2 LYM10 0 12133. 1 H 11.9 96 1.53E- 02 21.9 LYM14 8 12172. 1 E 8.25 1.24E- 01 3.3 LYM16 2 12231. 3 H 12.2 08 2.21E- 02 24.1 LYM95 12121. 2 E 8.25 1.24E- 01 3.3 LYM28 9 12493. 2 H 14.5 44 2.84E- 02 47.8 LYM13 0 12331. 3 E 8.75 1.31E- 01 9.6 LYM11 9 12463. 2 H 13.3 26 3.16E- 02 35.4 LYM13 0 12334. 1 E 8.75 1.31E- 01 9.6 LYM17 11684. 4 H 12.3 64 3.64E- 02 25.7 LYM13 7 12151. 1 E 9.25 1.43E- 01 15.9 LYM14 1 12404. 2 H 11.4 75 3.87E- 02 16.6 LYM68 11941. 4 E 8.41 1 1.43E- 01 5.3 2016213786 11 Aug 2016 307 Gene name Event I D Mea n P value % incr. vs. cont. Gene name Event I D Mea n P value % incr. vs. cont. LYM1 11603. 2 H 12.6 74 4.14E- 02 28.8 LYM17 0 12453. 2 E 8.95 5 1.60E- 01 12.2 LYM13 8 12561. 1 H 16.1 27 4.40E- 02 63.9 LYM11 1 12254. 3 E 8.62 5 1.71E- 01 8 LYM28 9 12493. 6 H 11.2 2 6.44E- 02 14 LYM10 0 12134. 1 E 8.43 8 1.72E- 01 5.7 LYM26 8 12483. 2 H 12.0 16 8.02E- 02 22.1 LYM14 12051. 4 E 8.43 8 1.72E- 01 5.7 LYM10 2 12221. 1 H 11.1 37 8.39E- 02 13.2 LYM68 11942. 2 E 8.43 8 1.72E- 01 5.7 LYM19 11751. 5 H 13.3 1 8.63E- 02 35.3 LYM26 8 12482. 3 E 8.81 3 1.79E- 01 10.4 LYM13 11771. 6 H 11.5 97 9.59E- 02 17.9 LYM10 0 12131. 3 E 8.5 2.31E- 01 6.5 LYM9 11632. 2 H 11.3 93 1.03E- 01 15.8 LYM10 0 12133. 3 E 8.5 2.31E- 01 6.5 LYM9 11632. 1 H 16.5 55 1.11E- 01 68.2 LYM13 8 12566. 1 E 8.5 2.31E- 01 6.5 LYM1 11604. 4 H 14.5 31 1.12E- 01 47.7 LYM24 12061. 2 E 8.5 2.31E- 01 6.5 LYM14 8 12174. 1 H 14.4 88 1.13E- 01 47.2 LYM26 11824. 6 E 8.5 2.31E- 01 6.5 LYM14 1 12402. 4 H 14.4 02 1.20E- 01 46.4 LYM25 4 12472. 3 E 8.25 2.39E- 01 3.3 LYM10 11742. 2 H 13.9 28 1.24E- 01 41.5 LYM10 5 12293. 1 E 8.18 8 2.52E- 01 2.5 LYM13 8 12562. 1 H 10.9 15 1.30E- 01 10.9 LYM51 11891. 1 E 8.18 8 2.52E- 01 2.5 LYM19 11753. 1 H 12.6 87 1.39E- 01 28.9 LYM67 11781. 5 E 8.18 8 2.52E- 01 2.5 LYM14 3 12521. 1 H 11.2 54 1.45E- 01 14.4 LYM29 0 12502. 1 E 8.75 2.56E- 01 9.6 LYM13 2 12271. 4 H 12.1 4 1.46E- 01 23.4 LYM14 8 12173. 1 E 9 2.70E- 01 12.7 LYM11 9 12462. 2 H 17.0 13 1.48E- 01 72.9 LYM11 1 12251. 1 E 8.56 3 2.76E- 01 7.2 LYM17 4 12411. 2 H 14.0 25 1.60E- 01 42.5 LYM11 9 12462. 1 E 8.56 3 2.76E- 01 7.2 LYM11 3 12442. 1 H 10.8 41 1.67E- 01 10.2 LYM15 2 12372. 1 E 8.56 3 2.76E- 01 7.2 LYM15 11612. 2 H 11.8 62 1.76E- 01 20.5 LYM51 11893. 4 E 8.56 3 2.76E- 01 7.2 LYM4 11705. 2 H 11.3 3 1.76E- 01 15.1 LYM15 2 12372. 2 E 8.31 3 2.80E- 01 4.1 LYM19 11754. 1 H 11.7 11 1.84E- 01 19 LYM17 2 12301. 2 E 8.31 3 2.80E- 01 4.1 LYM12 9 12573. 5 H 10.7 42 2.00E- 01 9.2 LYM26 8 12483. 2 E 8.31 3 2.80E- 01 4.1 LYM9 11633. 7 H 12.3 18 2.07E- 01 25.2 LYM31 11923. 1 E 8.31 3 2.80E- 01 4.1 LYM2 11692. 3 H 10.8 66 2.22E- 01 10.4 LYM13 8 12561. 3 E 8.81 3 2.84E- 01 10.4 2016213786 11 Aug 2016 308 Gene name Event I D Mea n P value % incr. vs. cont. Gene name Event I D Mea n P value % incr. vs. cont. LYM14 3 12524. 2 H 11.8 56 2.30E- 01 20.5 LYM31 11923. 4 E 8.81 3 2.84E- 01 10.4 LYM13 0 12332. 2 H 13.3 97 2.34E- 01 36.2 LYM29 0 12504. 1 E 8.83 2.91E- 01 10.6 LYM11 9 12462. 1 H 14.4 98 2.51E- 01 47.3 LYM62 12021. 1 E 8.62 5 3.08E- 01 8 LYM21 11673. 1 H 11.7 72 2.65E- 01 19.6 LYM13 2 12271. 4 E 8.37 5 3.23E- 01 4.9 LYM17 4 12414. 3 H 14.9 66 2.87E- 01 52.1 LYM13 7 12154. 5 E 8.68 8 3.33E- 01 00 00* LYM13 8 12561. 3 H 14.5 29 2.90E- 01 47.7 LYM68 11943. 2 E 8.68 8 3.33E- 01 00 00* LYM14 1 12404. 3 H 12.2 56 2.98E- 01 24.6 LYM15 2 12376. 1 E 8.43 8 3.55E- 01 5.7 LYM15 11612. 3 H 13.1 03 2.99E- 01 33.2 LYM29 0 12502. 4 E 8.43 8 3.55E- 01 5.7 LYM13 4 12311. 2 H 12.6 8 3.01E- 01 28.9 LYM31 11922. 3 E 8.43 8 3.55E- 01 5.7 LYM15 11611. 3 H 12.5 42 3.17E- 01 27.5 LYM53 11844. 2 E 8.43 8 3.55E- 01 5.7 LYM19 11751. 4 H 13.2 51 3.21E- 01 34.7 LYM11 1 12254. 4 E 9.18 8 3.72E- 01 15.1 LYM16 2 12231. 1 H 12.6 69 3.42E- 01 28.8 LYM15 3 12321. 2 E 8.49 1 3.76E- 01 6.3 LYM28 9 12491. 4 H 11.3 87 3.46E- 01 15.7 LYM15 2 12371. 2 E 8.56 3 3.96E- 01 7.2 LYM17 11684. 5 H 10.5 15 3.52E- 01 6.9 LYM10 5 12295. 2 E 8.62 5 4.09E- 01 8 LYM15 2 12371. 2 H 12.3 07 3.54E- 01 25.1 LYM30 11912. 6 E 8.31 3 4.71E- 01 4.1 LYM21 11671. 2 H 12.0 4 3.73E- 01 22.4 LYM51 11892. 1 E 8.31 3 4.71E- 01 4.1 LYM29 0 12501. 3 H 11.4 64 3.76E- 01 16.5 LYM57 12012. 2 E 8.31 3 4.71E- 01 4.1 LYM16 11624. 4 H 10.4 69 3.83E- 01 6.4 LYM13 8 12562. 1 E 8.18 8 4.71E- 01 2.5 LYM14 1 12404. 4 H 12.4 83 3.95E- 01 26.9 LYM14 0 12261. 4 E 8.18 8 4.71E- 01 2.5 LYM28 9 12491. 1 H 13.3 58 3.97E- 01 35.8 LYM16 2 12231. 1 E 8.18 8 4.71E- 01 2.5 LYM17 11683. 1 H 10.4 48 4.15E- 01 6.2 LYM14 0 12262. 3 E 8.37 5 4.75E- 01 4.9 LYM14 8 12173. 1 H 12.8 42 4.17E- 01 30.5 LYM14 8 12171. 2 E 8.5 4.82E- 01 6.5 LYM16 2 12234. 4 H 14.1 45 4.21E- 01 43.7 LYM30 11912. 7 E 8.56 3 4.85E- 01 7.2 LYM13 11772. 1 H 10.8 15 4.47E- 01 9.9 LYM26 8 12481. 1 E 8.62 5 4.87E- 01 8 LYM17 4 12411. 3 H 11.9 25 4.47E- 01 21.2 LYM10 0 12133. 1 E 8.12 5 5.09E- 01 1.8 LYM26 8 12483. 4 H 11.4 76 4.61E- 01 16.6 LYM13 7 12152. 1 E 8.12 5 5.09E- 01 1.8 2016213786 11 Aug 2016 309 Gene name Event I D Mea n P value % incr. vs. cont. Gene name Event I D Mea n P value % incr. vs. cont. LYM17 4 12412. 1 H 11.5 03 4.65E- 01 16.9 LYM14 12052. 5 E 8.12 5 5.09E- 01 1.8 LYM10 2 12222. 3 H 12.8 38 4.66E- 01 30.5 LYM26 11824. 5 E 8.12 5 5.09E- 01 1.8 LYM11 1 12251. 1 H 11.9 87 4.83E- 01 21.8 LYM13 2 12275. 1 E 8.56 3 5.52E- 01 7.2 LYM21 11672. 4 H 11.7 25 4.84E- 01 19.2 LYM53 11842. 4 E 8.5 5.58E- 01 6.5 LYM26 8 12482. 3 H 10.7 87 4.91E- 01 9.6 LYM57 12012. 6 E 8.25 6.05E- 01 3.3 LYM17 4 12414. 2 H 10.2 74 5.09E- 01 4.4 LYM69 11853. 4 E 8.5 6.15E- 01 6.5 LYM10 11744. 5 H 11.5 27 5.13E- 01 17.1 LYM13 2 12276. 1 E 8.24 1 6.23E- 01 3.2 LYM29 0 12502. 4 H 11.7 49 5.22E- 01 19.4 LYM10 5 12294. 3 E 8.18 8 6.34E- 01 2.5 LYM17 11682. 1 H 12.2 86 5.68E- 01 24.9 LYM69 11852. 4 E 8.18 8 6.34E- 01 2.5 LYM10 5 12294. 2 H 12.2 91 6.34E- 01 24.9 LYM95 12124. 5 E 8.06 3 6.47E- 01 1 LYM13 7 12153. 1 H 10.9 38 6.48E- 01 11.2 LYM95 12124. 6 E 8.12 5 6.82E- 01 1.8 LYM17 11681. 4 H 10.4 05 6.58E- 01 5.7 LYM43 11793. 2 E 8.43 8 7.13E- 01 5.7 LYM10 11742. 1 H 11.3 48 7.13E- 01 15.3 LYM13 0 12332. 1 E 8.37 5 7.33E- 01 4.9 LYM11 1 12252. 2 H 11.4 94 7.14E- 01 16.8 LYM14 0 12261. 1 E 8.25 7.45E- 01 3.3 LYM10 0 12131. 3 H 10.8 07 7.19E- 01 9.8 LYM67 11782. 6 E 8.06 3 7.71E- 01 1 LYM14 0 12261. 4 H 10.2 94 7.56E- 01 4.6 LYM14 12051. 1 E 8.12 5 7.75E- 01 1.8 LYM9 11633. 2 H 10.5 62 7.61E- 01 7.3 LYM25 4 12474. 4 E 8.18 8 7.80E- 01 2.5 LYM16 2 12233. 2 H 10.5 24 7.66E- 01 6.9 LYM26 8 12482. 1 E 8.25 9 8.09E- 01 3.4 LYM13 2 12275. 1 H 10.0 29 7.80E- 01 1.9 LYM69 11854. 2 E 8.10 7 8.10E- 01 1.5 LYM14 8 12172. 1 H 10.7 95 8.12E- 01 9.7 LYM13 0 12333. 1 E 8.06 3 8.49E- 01 1 LYM26 8 12482. 1 H 10.4 8 8.16E- 01 6.5 LYM13 8 12564. 1 E 8.06 3 8.49E- 01 1 LYM29 0 12502. 1 H 10.4 11 8.38E- 01 5.8 LYM17 0 12452. 3 E 8.06 3 8.49E- 01 1 LYM22 11762. 1 H 10.1 61 8.39E- 01 3.3 LYM13 4 12311. 2 E 8.12 5 8.60E- 01 1.8 LYM1 11601. 1 H 10.2 4 8.44E- 01 4.1 LYM62 12022. 2 E 8.12 5 8.60E- 01 1.8 LYM2 11693. 3 H 10.0 26 8.49E- 01 1.9 LYM66 11954. 4 E 8.12 5 8.82E- 01 1.8 LYM14 3 12521. 2 H 9.99 5 9.08E- 01 1.6 LYM3 12043. 1 E 8.06 3 9.13E- 01 1 2016213786 11 Aug 2016 310 Gene name Event I D Mea n P value % incr. vs. cont. Gene name Event I D Mea n P value % incr. vs. cont. LYM13 11771. 9 H 9.91 8 9.11E- 01 0.8 LYM15 2 12373. 1 E 8 9.40E- 01 0.2 LYM29 0 12504. 1 H 10.0 34 9.18E- 01 2 LYM15 3 12322. 1 E 8 9.63E- 01 0.2 LYM14 3 12523. 4 H 10.0 41 9.29E- 01 2 LYM31 11924. 4 E 8 9.80E- 01 0.2 LYM10 2 12222. 6 H 10.0 68 9.54E- 01 2.3 CONTR OL _ E 7.98 4 _ 0 LYM11 1 12254. 4 H 9.86 5 9.76E- 01 0.3 LYM13 7 12151. 1 F 0.63 6 3.25E- 04 50 CONTR OL _ H 9.84 _ 0 LYM57 12013. 5 F 0.60 5 7.25E- 04 42.7 LYM1 11602. 6 J 0.05 2.90E- 05 82.4 LYM13 4 12314. 2 F 0.60 5 7.28E- 04 42.7 LYM10 11741. 2 J 0.04 7 2.61E- 04 69.6 LYM13 8 12561. 3 F 0.60 3 8.37E- 04 42.2 LYM14 8 12171. 2 J 0.04 4 1.16E- 03 57.9 LYM51 11893. 2 F 0.60 7 1.97E- 03 43 LYM14 3 12524. 7 J 0.04 3 1.72E- 03 56 LYM26 8 12482. 3 F 0.57 6 2.18E- 03 35.7 LYM11 9 12462. 2 J 0.04 4 2.18E- 03 60.3 LYM68 11942. 3 F 0.57 2.74E- 03 34.3 LYM9 11632. 1 J 0.04 2 3.46E- 03 51.9 LYM14 8 12174. 1 F 0.79 5 3.37E- 03 87.5 LYM13 8 12561. 1 J 0.03 9 1.28E- 02 42.5 LYM29 0 12502. 4 F 0.56 3 3.59E- 03 32.8 LYM1 11604. 4 J 0.03 9 1.45E- 02 41.6 LYM69 11853. 5 F 0.63 4.12E- 03 48.5 LYM1 11602. 1 J 0.03 9 1.68E- 02 41.3 LYM68 11941. 3 F 0.67 6 4.18E- 03 59.3 LYM13 8 12561. 3 J 0.03 8 2.14E- 02 39.2 LYM13 7 12153. 1 F 0.54 4 7.80E- 03 28.2 LYM28 9 12493. 2 J 0.03 8 3.13E- 02 38 LYM13 7 12154. 5 F 0.58 4 1.03E- 02 37.8 LYM10 11742. 2 J 0.03 8 3.37E- 02 35.8 LYM14 3 12521. 2 F 0.54 1 1.35E- 02 27.5 LYM17 4 12414. 3 J 0.03 8 3.60E- 02 37.6 LYM43 11791. 5 F 0.55 2 1.40E- 02 30.2 LYM16 2 12234. 4 J 0.03 9 3.75E- 02 39.7 LYM30 11913. 4 F 0.57 8 1.86E- 02 36.3 LYM13 0 12333. 1 J 0.03 7 4.04E- 02 34.6 LYM30 11913. 5 F 0.53 7 1.99E- 02 26.7 LYM10 2 12222. 2 J 0.03 7 4.21E- 02 33.3 LYM29 0 12501. 3 F 0.51 6 2.54E- 02 21.7 LYM17 4 12411. 2 J 0.03 7 4.72E- 02 33.9 LYM53 11841. 1 F 0.63 2 2.58E- 02 49.1 LYM16 2 12234. 3 J 0.03 7 4.72E- 02 34 LYM17 0 12453. 2 F 0.51 1 3.14E- 02 20.5 LYM15 11614. 3 J 0.03 7 4.86E- 02 32.3 LYM14 0 12264. 1 F 0.50 8 3.58E- 02 19.9 LYM14 8 12174. 1 J 0.03 6 5.71E- 02 30.8 LYM30 11913. 3 F 0.51 3 4.45E- 02 20.9 2016213786 11 Aug 2016 311 Gene name Event I D Mea n P value % incr. vs. cont. Gene name Event I D Mea n P value % incr. vs. cont. LYM10 5 12293. 1 J 0.03 6 5.84E- 02 31.5 LYM10 5 12297. 1 F 0.50 3 4.63E- 02 18.6 LYM14 0 12262. 3 J 0.03 6 6.17E- 02 30 LYM62 12022. 1 F 0.50 1 5.09E- 02 18.2 LYM11 9 12462. 1 J 0.03 6 6.65E- 02 30.3 LYM31 11923. 4 F 0.57 4 5.51E- 02 35.4 LYM10 11744. 1 J 0.03 6 7.19E- 02 29.9 LYM68 11943. 2 F 0.60 4 5.83E- 02 42.4 LYM19 11751. 5 J 0.03 6 7.62E- 02 29.3 LYM15 2 12372. 2 F 0.51 7 5.83E- 02 21.9 LYM14 1 12402. 4 J 0.03 6 7.71E- 02 30.2 LYM10 5 12295. 2 F 0.55 2 6.04E- 02 30.1 LYM15 2 12372. 2 J 0.03 5 9.41E- 02 27.8 LYM13 7 12152. 1 F 0.50 4 6.15E- 02 18.8 LYM13 4 12311. 2 J 0.03 6 9.65E- 02 28.5 LYM13 8 12561. 1 F 0.64 4 7.28E- 02 51.8 LYM19 11751. 4 J 0.03 6 9.82E- 02 28.8 LYM62 12021. 1 F 0.50 4 8.04E- 02 18.8 LYM15 11611. 3 J 0.03 6 1.02E- 01 30.1 LYM30 11912. 6 F 0.52 1 9.04E- 02 22.9 LYM16 2 12231. 3 J 0.03 5 1.13E- 01 25.7 LYM11 1 12252. 2 F 0.81 7 9.40E- 02 92.5 LYM15 11612. 3 J 0.03 5 1.21E- 01 26.5 LYM11 9 12462. 2 F 0.51 3 9.81E- 02 21 LYM14 8 12173. 1 J 0.03 5 1.32E- 01 26.4 LYM29 0 12502. 2 F 0.52 4 1.07E- 01 23.6 LYM1 11603. 2 J 0.03 4 1.32E- 01 24.2 LYM10 0 12131. 2 F 0.57 5 1.17E- 01 35.6 LYM17 11684. 4 J 0.03 4 1.34E- 01 24 LYM14 12051. 1 F 0.48 8 1.25E- 01 15.1 LYM17 4 12412. 1 J 0.03 5 1.37E- 01 26.8 LYM29 0 12502. 1 F 0.48 1.39E- 01 13.1 LYM16 2 12231. 1 J 0.03 4 1.41E- 01 24.4 LYM14 3 12524. 2 F 0.59 4 1.41E- 01 40 LYM13 2 12273. 2 J 0.03 4 1.52E- 01 22.6 LYM13 8 12562. 1 F 0.51 2 1.65E- 01 20.7 LYM13 2 12271. 4 J 0.03 4 1.55E- 01 23.2 LYM13 8 12564. 1 F 0.47 2 1.84E- 01 11.3 LYM4 11705. 2 J 0.03 4 1.60E- 01 23.1 LYM17 2 12301. 2 F 0.51 1 1.88E- 01 20.4 LYM19 11753. 1 J 0.03 4 1.68E- 01 21.9 LYM15 2 12376. 1 F 0.52 8 1.96E- 01 24.5 LYM11 9 12461. 4 J 0.03 4 1.68E- 01 22.2 LYM14 12052. 4 F 0.53 2 1.98E- 01 25.5 LYM28 9 12491. 1 J 0.03 4 1.81E- 01 21.7 LYM11 9 12462. 1 F 0.56 7 2.22E- 01 33.7 LYM11 9 12463. 2 J 0.03 4 1.84E- 01 21.5 LYM10 0 12134. 1 F 0.50 8 2.22E- 01 19.7 LYM14 1 12404. 3 J 0.03 3 2.00E- 01 21 LYM10 5 12294. 3 F 0.51 6 2.28E- 01 21.6 LYM13 0 12332. 2 J 0.03 4 2.03E- 01 21.2 LYM13 2 12271. 4 F 0.5 2.30E- 01 17.9 2016213786 11 Aug 2016 312 Gene name Event I D Mea n P value % incr. vs. cont. Gene name Event I D Mea n P value % incr. vs. cont. LYM14 1 12404. 4 J 0.03 3 2.07E- 01 20.4 LYM51 11891. 1 F 0.47 1 2.32E- 01 11 LYM4 11706. 5 J 0.03 3 2.13E- 01 19.8 LYM67 11783. 5 F 0.54 1 2.36E- 01 27.6 LYM9 11633. 7 J 0.03 3 2.16E- 01 21 LYM26 11824. 6 F 0.51 6 2.42E- 01 21.6 LYM15 2 12371. 2 J 0.03 3 2.34E- 01 19.7 LYM26 8 12481. 1 F 0.52 2 2.44E- 01 23 LYM17 11682. 1 J 0.03 3 2.45E- 01 20.4 LYM14 12051. 4 F 0.46 7 2.48E- 01 10.2 LYM21 11673. 1 J 0.03 3 2.57E- 01 18.1 LYM14 8 12171. 2 F 0.46 8 2.60E- 01 10.4 LYM21 11672. 4 J 0.03 3 2.70E- 01 18.7 LYM13 0 12332. 2 F 0.46 6 2.86E- 01 9.9 LYM15 11612. 2 J 0.03 2 2.77E- 01 17.4 LYM10 0 12133. 3 F 0.47 4 2.88E- 01 11.8 LYM9 11632. 2 J 0.03 2 2.83E- 01 17.2 LYM53 11844. 2 F 0.52 2 3.01E- 01 23.1 LYM14 3 12521. 1 J 0.03 2 2.83E- 01 17.1 LYM51 11893. 4 F 0.61 5 3.06E- 01 45.1 LYM14 3 12524. 2 J 0.03 2 2.84E- 01 17.3 LYM15 2 12372. 1 F 0.62 5 3.14E- 01 47.3 LYM10 2 12222. 3 J 0.03 3 2.90E- 01 18.6 LYM11 1 12251. 1 F 0.46 8 3.26E- 01 10.4 LYM10 11744. 5 J 0.03 2 3.16E- 01 16.9 LYM16 2 12231. 3 F 0.47 3.29E- 01 10.8 LYM13 11771. 6 J 0.03 2 3.27E- 01 16.2 LYM11 9 12461. 1 F 0.64 9 3.29E- 01 52.9 LYM11 1 12251. 1 J 0.03 2 3.47E- 01 16.1 LYM14 3 12524. 7 F 0.58 3 3.35E- 01 37.3 LYM10 5 12294. 2 J 0.03 2 3.57E- 01 17.1 LYM13 0 12331. 3 F 0.48 3.48E- 01 13.2 LYM17 4 12411. 3 J 0.03 2 3.66E- 01 14.4 LYM13 0 12334. 1 F 0.47 6 3.58E- 01 12.3 LYM19 11754. 1 J 0.03 2 3.67E- 01 14.1 LYM13 2 12275. 1 F 0.45 6 3.63E- 01 7.5 LYM26 8 12483. 2 J 0.03 1 3.73E- 01 13.8 LYM11 1 12254. 4 F 0.55 3 3.74E- 01 30.4 LYM26 8 12483. 4 J 0.03 2 3.80E- 01 15 LYM11 1 12254. 3 F 0.60 3 3.81E- 01 42.1 LYM29 0 12502. 4 J 0.03 2 3.97E- 01 14.2 LYM14 8 12173. 1 F 0.51 3 4.04E- 01 20.9 LYM28 9 12493. 6 J 0.03 1 4.46E- 01 11.8 LYM68 11942. 2 F 0.48 9 4.14E- 01 15.3 LYM14 1 12404. 2 J 0.03 1 4.48E- 01 12.2 LYM57 12012. 2 F 0.46 2 4.14E- 01 9 LYM13 11772. 1 J 0.03 1 4.52E- 01 12.1 LYM57 12012. 6 F 0.46 2 4.28E- 01 9 LYM21 11671. 2 J 0.03 1 4.72E- 01 11.1 LYM10 0 12131. 3 F 0.48 2 4.31E- 01 13.6 LYM12 9 12573. 5 J 0.03 1 4.89E- 01 10.8 LYM15 3 12321. 2 F 0.50 7 4.37E- 01 19.5 2016213786 11 Aug 2016 313 Gene name Event I D Mea n P value % incr. vs. cont. Gene name Event I D Mea n P value % incr. vs. cont. LYM17 11681. 4 J 0.03 1 4.90E- 01 10.8 LYM16 2 12234. 3 F 0.45 6 4.41E- 01 7.6 LYM14 3 12521. 2 J 0.03 5.23E- 01 10.1 LYM24 12061. 2 F 0.51 5 4.44E- 01 21.5 LYM14 8 12172. 1 J 0.03 1 5.23E- 01 11.5 LYM13 4 12312. 4 F 0.46 7 4.57E- 01 10.2 LYM28 9 12491. 4 J 0.03 5.61E- 01 9.4 LYM68 11941. 4 F 0.46 5 4.72E- 01 9.6 LYM10 0 12133. 1 J 0.03 5.63E- 01 9 LYM30 11912. 7 F 0.48 5 4.92E- 01 14.2 LYM10 2 12221. 1 J 0.03 5.66E- 01 9.1 LYM13 2 12276. 1 F 0.51 3 4.98E- 01 21 LYM10 0 12131. 3 J 0.03 5.87E- 01 9.1 LYM95 12124. 4 F 0.45 4 5.03E- 01 7.1 LYM2 11692. 3 J 0.03 5.92E- 01 8.4 LYM14 8 12174. 2 F 0.46 7 5.95E- 01 10.2 LYM16 11624. 4 J 0.03 6.06E- 01 8 LYM43 11791. 4 F 0.48 8 5.95E- 01 15.1 LYM29 0 12501. 3 J 0.03 6.10E- 01 8.3 LYM15 2 12371. 2 F 0.47 6 6.25E- 01 12.3 LYM10 11742. 1 J 0.03 6.16E- 01 8.9 LYM66 11954. 4 F 0.50 1 6.29E- 01 18.2 LYM13 8 12562. 1 J 0.03 6.36E- 01 7.3 LYM67 11781. 5 F 0.44 6 6.32E- 01 5.3 LYM17 11684. 5 J 0.03 6.40E- 01 7.2 LYM67 11782. 6 F 0.44 2 6.43E- 01 4.3 LYM11 1 12252. 2 J 0.03 6.46E- 01 8.2 LYM14 0 12261. 1 F 0.46 5 6.49E- 01 9.6 LYM26 8 12482. 1 J 0.03 6.52E- 01 7.8 LYM17 2 12302. 2 F 0.47 1 6.57E- 01 11 LYM17 11683. 1 J 0.02 9 6.68E- 01 6.6 LYM31 11922. 3 F 0.47 6.61E- 01 10.8 LYM1 11601. 1 J 0.02 9 6.76E- 01 6.7 LYM14 12052. 5 F 0.43 9 6.69E- 01 3.4 LYM13 7 12153. 1 J 0.02 9 6.95E- 01 6.6 LYM51 11894. 2 F 0.44 6.79E- 01 3.7 LYM16 2 12233. 2 J 0.02 9 6.97E- 01 6.4 LYM17 0 12452. 3 F 0.44 1 6.91E- 01 3.9 LYM26 8 12482. 3 J 0.02 9 7.03E- 01 6 LYM15 3 12322. 1 F 0.48 5 6.92E- 01 14.4 LYM13 0 12334. 1 J 0.02 9 7.32E- 01 5.2 LYM62 12022. 2 F 0.46 4 7.01E- 01 9.4 LYM22 11762. 1 J 0.02 9 8.38E- 01 3.2 LYM10 5 12293. 1 F 0.44 8 7.04E- 01 5.7 LYM14 0 12261. 4 J 0.02 8 8.73E- 01 2.6 LYM31 11923. 1 F 0.45 1 7.09E- 01 6.4 LYM14 3 12523. 4 J 0.02 8 9.21E- 01 1.6 LYM69 11854. 2 F 0.44 7 7.13E- 01 5.5 LYM11 1 12254. 4 J 0.02 8 9.41E- 01 1.1 LYM26 8 12482. 1 F 0.48 6 7.27E- 01 14.5 LYM2 11693. 3 J 0.02 8 9.79E- 01 0.4 LYM11 9 12461. 4 F 0.44 4 7.34E- 01 4.8 2016213786 11 Aug 2016 314 Gene name Event I D Mea n P value % incr. vs. cont. Gene name Event I D Mea n P value % incr. vs. cont. LYM10 2 12222. 6 J 0.02 8 9.79E- 01 0.5 LYM26 8 12483. 2 F 0.46 1 7.41E- 01 8.6 LYM11 3 12442. 1 J 0.02 8 9.82E- 01 0.4 LYM11 1 12251. 3 F 0.45 2 7.42E- 01 6.5 CONTR OL _ J 0.02 8 _ 0 LYM16 2 12231. 1 F 0.45 7.55E- 01 6.2 LYM11 9 12462. 2 K 0.62 7 1.12E- 02 31.8 LYM10 0 12133. 1 F 0.44 6 7.57E- 01 5.3 LYM14 8 12174. 1 K 0.61 7 2.05E- 02 29.8 LYM26 11824. 5 F 0.44 2 7.76E- 01 4.1 LYM26 8 12483. 2 K 0.60 7 2.07E- 02 27.7 LYM15 2 12373. 1 F 0.46 7.98E- 01 8.4 LYM26 8 12482. 3 K 0.61 2 2.74E- 02 28.6 LYM69 11853. 4 F 0.45 5 8.07E- 01 7.3 LYM10 2 12222. 6 K 0.61 6 3.04E- 02 29.6 LYM25 4 12474. 4 F 0.46 6 8.11E- 01 9.9 LYM4 11706. 5 K 0.60 3 3.66E- 02 26.7 LYM17 2 12301. 3 F 0.43 9 8.30E- 01 3.6 LYM10 2 12222. 2 K 0.60 8 4.08E- 02 27.9 LYM95 12124. 5 F 0.43 8.69E- 01 1.4 LYM14 3 12524. 7 K 0.61 4 4.15E- 02 29.2 LYM13 0 12333. 1 F 0.43 8 8.73E- 01 3.2 LYM15 11611. 3 K 0.59 4.46E- 02 24.1 LYM14 8 12172. 1 F 0.43 1 8.75E- 01 1.7 LYM14 0 12261. 1 K 0.58 5 4.64E- 02 22.9 LYM53 11842. 4 F 0.44 9 8.83E- 01 5.8 LYM11 9 12461. 4 K 0.58 9 4.73E- 02 23.8 LYM43 11793. 2 F 0.44 6 9.06E- 01 5.1 LYM21 11674. 5 K 0.58 1 5.23E- 02 22.2 LYM14 0 12262. 3 F 0.43 3 9.11E- 01 2.2 LYM13 2 12271. 4 K 0.58 4 5.49E- 02 22.8 LYM25 4 12472. 3 F 0.42 9 9.16E- 01 1.1 LYM13 0 12332. 2 K 0.58 6 6.37E- 02 23.3 LYM13 7 12151. 2 F 0.43 6 9.21E- 01 2.7 LYM10 0 12131. 2 K 0.58 4 7.48E- 02 22.8 CONTR OL _ F 0.42 4 _ 0 LYM10 0 12133. 1 K 0.58 3 8.16E- 02 22.7 LYM14 8 12174. 1 G 10.5 31 6.00E- 05 46.2 LYM13 8 12561. 1 K 0.58 2 9.29E- 02 22.5 LYM10 5 12297. 1 G 9.40 6 9.40E- 05 30.6 LYM14 1 12402. 4 K 0.57 8 9.33E- 02 21.5 LYM13 7 12154. 5 G 9.27 2 1.82E- 04 28.7 LYM10 11741. 2 K 0.57 2 9.81E- 02 20.4 LYM29 0 12502. 1 G 9.12 1 2.85E- 04 26.6 LYM10 11742. 2 K 0.57 1 1.03E- 01 20 LYM13 2 12271. 4 G 8.89 9 5.40E- 04 23.5 LYM15 2 12372. 2 K 0.57 2 1.06E- 01 20.2 LYM11 1 12252. 2 G 8.92 3 5.44E- 04 23.9 LYM10 5 12293. 1 K 0.56 4 1.39E- 01 18.6 LYM29 0 12502. 2 G 8.83 2 7.44E- 04 22.6 LYM17 11681. 4 K 0.56 6 1.40E- 01 19.1 LYM14 3 12524. 2 G 8.77 9.08E- 04 21.7 2016213786 11 Aug 2016 315 Gene name Event I D Mea n P value % incr. vs. cont. Gene name Event I D Mea n P value % incr. vs. cont. LYM13 7 12153. 1 K 0.56 4 1.47E- 01 18.5 LYM26 8 12482. 3 G 8.97 3 1.05E- 03 24.6 LYM21 11671. 2 K 0.56 9 1.48E- 01 19.6 LYM67 11781. 5 G 8.53 4 2.64E- 03 18.5 LYM10 11742. 1 K 0.56 4 1.50E- 01 18.6 LYM13 8 12561. 1 G 10.3 11 3.08E- 03 43.1 LYM28 9 12491. 4 K 0.54 9 1.64E- 01 15.5 LYM13 8 12561. 3 G 9.90 1 3.55E- 03 37.4 LYM15 3 12321. 2 K 0.55 3 1.68E- 01 16.3 LYM57 12013. 5 G 9.58 3 3.82E- 03 33 LYM28 9 12491. 1 K 0.57 3 1.78E- 01 20.5 LYM14 3 12524. 7 G 8.42 2 3.87E- 03 16.9 LYM17 4 12411. 2 K 0.56 1.82E- 01 17.7 LYM29 0 12501. 3 G 8.47 4 4.45E- 03 17.6 LYM22 11764. 1 K 0.54 7 1.85E- 01 15 LYM15 3 12322. 1 G 8.56 6 4.91E- 03 18.9 LYM28 9 12493. 2 K 0.54 9 1.87E- 01 15.5 LYM67 11783. 5 G 8.89 6 8.15E- 03 23.5 LYM10 6 12142. 2 K 0.54 7 1.97E- 01 15 LYM14 0 12261. 1 G 8.62 4 9.34E- 03 19.7 LYM17 4 12412. 1 K 0.55 7 2.01E- 01 17.2 LYM43 11791. 5 G 8.22 7 1.13E- 02 14.2 LYM17 4 12414. 2 K 0.54 9 2.07E- 01 15.5 LYM26 8 12483. 2 G 8.17 3 1.25E- 02 13.4 LYM10 5 12297. 1 K 0.55 2.08E- 01 15.6 LYM11 1 12251. 1 G 8.20 6 1.25E- 02 13.9 LYM15 2 12373. 1 K 0.54 2 2.24E- 01 14 LYM10 0 12134. 1 G 8.49 3 1.46E- 02 17.9 LYM22 11764. 7 K 0.54 5 2.25E- 01 14.5 LYM30 11913. 5 G 9.10 6 1.46E- 02 26.4 LYM11 9 12462. 1 K 0.55 5 2.28E- 01 16.8 LYM13 4 12311. 2 G 8.00 5 2.81E- 02 11.1 LYM1 11602. 6 K 0.56 1 2.30E- 01 18 LYM13 0 12334. 1 G 8.53 9 3.38E- 02 18.5 LYM13 0 12334. 1 K 0.55 9 2.36E- 01 17.5 LYM16 2 12231. 1 G 9.30 8 3.90E- 02 29.2 LYM13 8 12564. 1 K 0.54 6 2.43E- 01 14.8 LYM30 11912. 7 G 7.96 2 4.08E- 02 10.5 LYM26 8 12481. 1 K 0.53 6 2.59E- 01 12.6 LYM68 11941. 3 G 10.2 35 4.13E- 02 42.1 LYM3 12041. 2 K 0.55 1 2.68E- 01 15.9 LYM10 0 12133. 1 G 8.26 4 5.83E- 02 14.7 LYM10 2 12222. 3 K 0.54 6 2.81E- 01 14.8 LYM15 3 12324. 1 G 9.05 9 5.91E- 02 25.7 LYM16 2 12234. 3 K 0.54 1 2.97E- 01 13.9 LYM10 0 12131. 3 G 7.84 5 6.29E- 02 8.9 LYM16 2 12234. 4 K 0.54 3.06E- 01 13.6 LYM26 8 12483. 4 G 8.17 6 6.43E- 02 13.5 LYM14 8 12173. 1 K 0.54 7 3.18E- 01 15.1 LYM31 11923. 4 G 8.75 7.07E- 02 21.5 LYM29 0 12501. 3 K 0.53 3 3.19E- 01 12 LYM57 12012. 2 G 8.17 4 8.06E- 02 13.5 2016213786 11 Aug 2016 316 Gene name Event I D Mea n P value % incr. vs. cont. Gene name Event I D Mea n P value % incr. vs. cont. LYM9 11632. 1 K 0.53 7 3.25E- 01 13 LYM17 4 12411. 3 G 9.04 6 8.44E- 02 25.6 LYM11 3 12442. 1 K 0.52 7 3.29E- 01 10.9 LYM53 11843. 2 G 7.79 6 8.61E- 02 8.2 LYM19 11754. 1 K 0.52 7 3.47E- 01 10.8 LYM13 7 12151. 1 G 10.0 24 8.70E- 02 39.1 LYM11 1 12251. 1 K 0.53 2 3.60E- 01 11.9 LYM11 1 12254. 3 G 8.78 6 9.05E- 02 22 LYM11 9 12463. 2 K 0.53 3 3.81E- 01 12.1 LYM95 12121. 2 G 7.75 2 1.05E- 01 7.6 LYM15 11614. 3 K 0.52 5 3.92E- 01 10.4 LYM16 2 12234. 4 G 8.33 7 1.12E- 01 15.7 LYM14 0 12264. 1 K 0.52 4 3.93E- 01 10.2 LYM30 11913. 3 G 8.02 4 1.18E- 01 11.4 LYM19 11753. 1 K 0.52 3 4.08E- 01 10 LYM10 5 12295. 2 G 8.79 8 1.36E- 01 22.1 LYM14 1 12404. 3 K 0.52 5 4.11E- 01 10.3 LYM3 12042. 1 G 7.69 7 1.37E- 01 6.8 LYM10 11744. 1 K 0.52 2 4.16E- 01 9.8 LYM13 2 12275. 1 G 7.68 6 1.44E- 01 6.7 LYM13 0 12331. 3 K 0.52 3 4.27E- 01 9.9 LYM68 11942. 2 G 8.30 5 1.48E- 01 15.3 LYM28 9 12493. 6 K 0.51 9 4.34E- 01 9.2 LYM13 7 12152. 1 G 8.27 8 1.51E- 01 14.9 LYM19 11752. 2 K 0.53 2 4.41E- 01 11.8 LYM15 2 12372. 1 G 9.36 1 1.57E- 01 29.9 LYM13 8 12562. 1 K 0.51 9 4.60E- 01 9.2 LYM26 8 12482. 1 G 9.01 1 1.64E- 01 25.1 LYM29 0 12502. 4 K 0.51 9 4.61E- 01 9.1 LYM13 4 12314. 2 G 9.93 5 1.83E- 01 37.9 LYM10 5 12294. 3 K 0.51 8 5.00E- 01 8.9 LYM16 2 12231. 3 G 8.42 8 1.87E- 01 17 LYM1 11603. 2 K 0.51 5 5.19E- 01 8.3 LYM66 11952. 1 G 8.19 4 1.92E- 01 13.7 LYM17 4 12414. 3 K 0.51 3 5.33E- 01 7.8 LYM66 11954. 4 G 8.63 1 2.06E- 01 19.8 LYM17 11682. 1 K 0.51 5 5.34E- 01 8.2 LYM43 11791. 4 G 8.57 4 2.13E- 01 19 LYM29 0 12502. 2 K 0.52 1 5.41E- 01 9.6 LYM26 11824. 6 G 8.67 2.15E- 01 20.3 LYM14 1 12404. 4 K 0.51 4 5.48E- 01 8.1 LYM31 11921. 3 G 8.12 7 2.23E- 01 12.8 LYM3 12041. 1 K 0.50 8 5.57E- 01 6.9 LYM14 8 12174. 2 G 9.02 6 2.26E- 01 25.3 LYM26 8 12482. 1 K 0.50 6 5.59E- 01 6.5 LYM11 1 12251. 3 G 8.39 6 2.31E- 01 16.5 LYM16 2 12233. 2 K 0.50 6 5.75E- 01 6.4 LYM24 12062. 3 G 8.37 8 2.38E- 01 16.3 LYM15 2 12371. 3 K 0.50 7 5.75E- 01 6.6 LYM13 7 12151. 2 G 7.63 7 2.41E- 01 6 LYM16 2 12231. 1 K 0.51 3 5.85E- 01 7.8 LYM11 1 12254. 4 G 8.57 1 2.44E- 01 19 2016213786 11 Aug 2016 317 Gene name Event I D Mea n P value % incr. vs. cont. Gene name Event I D Mea n P value % incr. vs. cont. LYM15 2 12371. 2 K 0.50 5 5.88E- 01 6.2 LYM68 11942. 3 G 7.98 9 2.45E- 01 10.9 LYM10 6 12141. 4 K 0.50 5 5.96E- 01 6.1 LYM15 3 12323. 2 G 7.58 8 2.51E- 01 5.3 LYM15 11612. 3 K 0.50 6 6.17E- 01 6.4 LYM13 8 12564. 1 G 8.79 9 2.53E- 01 22.1 LYM10 5 12297. 2 K 0.50 7 6.20E- 01 6.5 LYM67 11782. 6 G 7.56 3 2.57E- 01 5 LYM10 5 12294. 2 K 0.50 5 6.39E- 01 6.1 LYM68 11943. 2 G 8.64 9 2.60E- 01 20.1 LYM21 11672. 4 K 0.50 4 6.50E- 01 5.9 LYM62 12022. 1 G 8.78 1 2.63E- 01 21.9 LYM1 11604. 4 K 0.5 6.53E- 01 5.1 LYM14 12051. 1 G 7.58 7 2.72E- 01 5.3 LYM15 11612. 2 K 0.50 2 6.56E- 01 5.6 LYM13 8 12562. 1 G 8.86 2 2.79E- 01 23 LYM14 1 12404. 2 K 0.50 1 6.61E- 01 5.3 LYM15 2 12376. 1 G 7.95 2 2.80E- 01 10.4 LYM17 11684. 4 K 0.50 2 6.69E- 01 5.5 LYM26 11821. 2 G 7.54 4 2.80E- 01 4.7 LYM19 11751. 4 K 0.50 4 6.71E- 01 5.9 LYM10 5 12294. 3 G 8.88 5 2.83E- 01 23.3 LYM10 11744. 5 K 0.49 8 6.80E- 01 4.8 LYM26 11824. 5 G 7.68 2 2.83E- 01 6.6 LYM4 11706. 3 K 0.49 6 6.93E- 01 4.4 LYM10 0 12131. 2 G 7.59 6 2.88E- 01 5.4 LYM13 2 12275. 1 K 0.49 8 7.10E- 01 4.8 LYM13 7 12153. 1 G 9.25 6 2.90E- 01 28.5 LYM11 3 12444. 4 K 0.49 4 7.42E- 01 3.8 LYM51 11891. 1 G 7.81 2.91E- 01 8.4 LYM12 9 12573. 5 K 0.49 4 7.44E- 01 3.8 LYM69 11853. 5 G 8.64 3 2.92E- 01 20 LYM13 11773. 2 K 0.49 2 7.46E- 01 3.5 LYM51 11893. 4 G 9.29 8 2.98E- 01 29.1 LYM13 0 12333. 1 K 0.49 5 7.48E- 01 4 LYM62 12022. 2 G 8.81 4 3.09E- 01 22.3 LYM16 11624. 4 K 0.49 2 7.53E- 01 3.4 LYM11 9 12462. 1 G 7.62 6 3.21E- 01 5.8 LYM14 3 12521. 1 K 0.49 4 7.62E- 01 3.8 LYM17 2 12301. 2 G 8.25 3.22E- 01 14.5 LYM12 9 12571. 3 K 0.49 3 7.92E- 01 3.7 LYM14 3 12521. 2 G 9.22 8 3.24E- 01 28.1 LYM13 11772. 2 K 0.48 8 8.40E- 01 2.6 LYM31 11924. 4 G 8.26 9 3.35E- 01 14.8 LYM9 11633. 2 K 0.48 6 8.54E- 01 2.2 LYM14 12052. 5 G 8.09 1 3.45E- 01 12.3 LYM29 0 12502. 1 K 0.48 7 8.54E- 01 2.4 LYM62 12021. 1 G 8.69 5 3.46E- 01 20.7 LYM9 11634. 5 K 0.48 4 8.82E- 01 1.7 LYM53 11841. 1 G 9.04 5 3.63E- 01 25.6 LYM10 6 12144. 4 K 0.48 4 8.84E- 01 1.8 LYM67 11782. 5 G 7.53 4 3.65E- 01 4.6 2016213786 11 Aug 2016 318 Gene name Event I D Mea n P value % incr. vs. cont. Gene name Event I D Mea n P value % incr. vs. cont. LYM17 4 12411. 3 K 0.48 5 8.98E- 01 1.9 LYM11 9 12461. 1 G 8.65 5 3.72E- 01 20.1 LYM26 8 12483. 4 K 0.48 2 9.01E- 01 1.5 LYM30 11912. 6 G 7.91 3.80E- 01 9.8 LYM12 9 12572. 2 K 0.48 1 9.19E- 01 1.2 LYM30 11913. 4 G 14.9 39 3.98E- 01 107.4 LYM13 4 12311. 2 K 0.48 9.39E- 01 0.9 LYM25 4 12471. 2 G 8.13 6 4.05E- 01 12.9 LYM9 11633. 7 K 0.48 9.41E- 01 0.8 LYM24 12061. 2 G 8.90 5 4.08E- 01 23.6 LYM13 11771. 9 K 0.47 9 9.49E- 01 0.7 LYM53 11844. 2 G 8.51 6 4.19E- 01 18.2 LYM13 7 12151. 1 K 0.47 9 9.51E- 01 0.7 LYM13 0 12333. 1 G 8.44 4.29E- 01 17.1 LYM13 4 12312. 3 K 0.47 8 9.61E- 01 0.6 LYM51 11893. 2 G 8.6 4.35E- 01 19.4 LYM16 2 12231. 3 K 0.47 8 9.64E- 01 0.6 LYM51 11892. 1 G 8.00 7 4.43E- 01 11.1 LYM2 11693. 3 K 0.47 7 9.81E- 01 0.3 LYM26 11824. 3 G 7.46 7 4.44E- 01 3.6 CONTR OL _ K 0.47 6 _ 0 LYM14 8 12173. 1 G 7.90 9 4.46E- 01 9.8 LYM1 11602. 6 L 2.50 7 2.00E- 05 100.5 LYM62 12023. 4 G 7.50 5 4.48E- 01 4.2 LYM10 11741. 2 L 2.40 5 3.80E- 05 92.3 LYM17 0 12453. 3 G 8.37 8 4.85E- 01 16.3 LYM11 9 12462. 2 L 2.19 1 8.04E- 04 75.2 LYM16 2 12234. 3 G 8.24 6 4.91E- 01 14.5 LYM9 11632. 1 L 2.13 4 1.01E- 03 70.6 LYM17 0 12452. 3 G 7.89 4.91E- 01 9.5 LYM14 3 12524. 7 L 2.09 4 1.12E- 03 67.4 LYM31 11922. 3 G 8.37 4 5.24E- 01 16.2 LYM14 8 12171. 2 L 2.03 3 1.84E- 03 62.6 LYM13 4 12313. 2 G 8.02 8 5.29E- 01 11.4 LYM13 8 12561. 1 L 2.04 1 2.32E- 03 63.2 LYM15 3 12321. 2 G 8.37 4 5.39E- 01 16.2 LYM17 4 12414. 3 L 1.92 1 9.20E- 03 53.6 LYM25 4 12472. 3 G 7.44 5 5.40E- 01 3.3 LYM1 11604. 4 L 1.85 3 1.20E- 02 48.1 LYM15 2 12371. 2 G 8.10 3 5.47E- 01 12.5 LYM10 2 12222. 2 L 1.84 7 1.29E- 02 47.7 LYM29 0 12502. 4 G 7.86 5 5.54E- 01 9.2 LYM13 0 12333. 1 L 1.86 8 1.31E- 02 49.3 LYM13 0 12332. 2 G 9.59 4 5.61E- 01 33.2 LYM14 8 12174. 1 L 1.84 1.45E- 02 47.1 LYM17 2 12302. 2 G 7.73 6 5.61E- 01 7.4 LYM28 9 12493. 2 L 1.86 8 1.45E- 02 49.3 LYM3 12041. 1 G 8.49 2 5.64E- 01 17.9 LYM14 1 12402. 4 L 1.84 1 1.66E- 02 47.2 LYM62 12022. 4 G 7.94 9 5.65E- 01 10.3 LYM11 9 12462. 1 L 1.84 1 1.92E- 02 47.2 LYM13 0 12331. 3 G 7.74 8 5.70E- 01 7.5 2016213786 11 Aug 2016 319 Gene name Event I D Mea n P value % incr. vs. cont. Gene name Event I D Mea n P value % incr. vs. cont. LYM10 11742. 2 L 1.79 5 2.33E- 02 43.5 LYM17 4 12411. 2 G 7.83 7 5.73E- 01 00 00* LYM13 8 12561. 3 L 1.82 3 2.34E- 02 45.8 LYM13 8 12566. 1 G 7.71 6 5.76E- 01 7.1 LYM1 11602. 1 L 1.79 2 2.41E- 02 43.2 LYM14 12052. 4 G 7.77 6 5.91E- 01 7.9 LYM10 5 12293. 1 L 1.77 6 2.81E- 02 42 LYM43 11791. 2 G 8.02 5 6.07E- 01 11.4 LYM17 4 12411. 2 L 1.77 8 3.09E- 02 42.1 LYM69 11853. 4 G 7.97 7 6.13E- 01 10.7 LYM10 11744. 1 L 1.75 2 3.26E- 02 40.1 LYM68 11941. 4 G 7.69 3 6.29E- 01 6.8 LYM16 2 12234. 4 L 1.83 8 3.42E- 02 47 LYM26 8 12481. 1 G 7.84 4 6.40E- 01 8.9 LYM15 2 12372. 2 L 1.74 4 4.01E- 02 39.4 LYM43 11793. 2 G 8.08 7 6.72E- 01 12.3 LYM4 11706. 5 L 1.72 9 4.16E- 02 38.3 LYM53 11842. 4 G 8.04 9 6.85E- 01 11.7 LYM16 2 12234. 3 L 1.74 2 4.19E- 02 39.3 LYM31 11923. 1 G 7.71 3 7.10E- 01 7.1 LYM13 0 12332. 2 L 1.71 7 5.60E- 02 37.3 LYM14 8 12172. 1 G 7.51 6 7.34E- 01 4.3 LYM19 11751. 5 L 1.69 2 6.21E- 02 35.3 LYM13 2 12276. 1 G 7.88 7 7.39E- 01 9.5 LYM15 11614. 3 L 1.67 6 6.35E- 02 34 LYM10 5 12294. 2 G 7.42 7 7.63E- 01 3.1 LYM11 9 12463. 2 L 1.67 5 7.13E- 02 33.9 LYM11 9 12462. 2 G 7.29 4 7.81E- 01 1.2 LYM14 0 12262. 3 L 1.65 8 7.47E- 02 32.6 LYM53 11841. 2 G 7.54 6 7.89E- 01 4.7 LYM15 11612. 3 L 1.67 5 7.83E- 02 33.9 LYM10 0 12133. 3 G 7.31 7 7.97E- 01 1.6 LYM28 9 12491. 1 L 1.68 2 8.02E- 02 34.5 LYM51 11894. 2 G 7.29 6 8.21E- 01 1.3 LYM13 0 12334. 1 L 1.65 8 8.07E- 02 32.6 LYM11 9 12461. 4 G 7.33 6 8.46E- 01 1.8 LYM19 11751. 4 L 1.68 4 8.28E- 02 34.6 LYM95 12124. 5 G 7.47 1 8.50E- 01 3.7 LYM19 11753. 1 L 1.62 5 1.03E- 01 29.9 LYM10 5 12293. 1 G 7.46 7 8.53E- 01 3.6 LYM13 4 12311. 2 L 1.64 1.05E- 01 31.1 LYM25 4 12474. 4 G 7.73 7 8.61E- 01 7.4 LYM16 2 12231. 1 L 1.63 7 1.06E- 01 30.9 LYM25 4 12474. 3 G 7.32 1 8.99E- 01 1.6 LYM13 2 12273. 2 L 1.61 9 1.07E- 01 29.5 LYM17 0 12453. 2 G 7.23 9 9.08E- 01 0.5 LYM1 11603. 2 L 1.61 4 1.1 OE-01 29 LYM17 2 12301. 3 G 7.31 9 9.09E- 01 1.6 LYM11 9 12461. 4 L 1.61 3 1.13E- 01 29 LYM17 0 12452. 4 G 7.24 9 9.33E- 01 0.6 LYM15 11611. 3 L 1.63 3 1.16E- 01 30.6 LYM69 11852. 4 G 7.22 5 9.80E- 01 0.3 2016213786 11 Aug 2016 320 Gene name Event I D Mea n P value % incr. vs. cont. Gene name Event I D Mea n P value % incr. vs. cont. LYM17 11684. 4 L 1.60 9 1.17E- 01 28.6 LYM14 12051. 4 G 7.24 4 9.80E- 01 0.6 LYM14 8 12173. 1 L 1.63 9 1.21E- 01 31 LYM14 3 12521. 1 G 7.21 1 9.94E- 01 0.1 LYM14 1 12404. 4 L 1.59 5 1.46E- 01 27.6 CONTR OL _ G 7.20 4 _ 0 LYM10 2 12222. 3 L 1.61 5 1.50E- 01 29.1 LYM13 8 12561. 1 H 25.0 53 4.46E- 04 61.4 LYM26 8 12483. 2 L 1.56 9 1.55E- 01 25.5 LYM13 4 12314. 2 H 23.0 18 4.64E- 04 48.3 LYM16 2 12231. 3 L 1.57 2 1.57E- 01 25.7 LYM26 8 12482. 3 H 22.6 16 7.44E- 04 45.7 LYM13 2 12271. 4 L 1.57 1.71E- 01 25.5 LYM43 11791. 5 H 23.8 24 1.69E- 03 53.5 LYM15 2 12371. 2 L 1.56 8 1.80E- 01 25.4 LYM10 0 12131. 2 H 24.7 77 2.60E- 03 59.6 LYM14 1 12404. 3 L 1.56 1.82E- 01 24.7 LYM14 0 12264. 1 H 20.4 54 8.48E- 03 31.8 LYM21 11671. 2 L 1.54 8 1.95E- 01 23.8 LYM68 11942. 3 H 21.8 99 9.46E- 03 41.1 LYM9 11633. 7 L 1.55 1 1.99E- 01 24 LYM57 12013. 5 H 21.3 79 1.02E- 02 37.7 LYM17 11682. 1 L 1.57 2 2.12E- 01 25.7 LYM14 3 12524. 2 H 22.0 43 1.20E- 02 42 LYM10 5 12294. 2 L 1.58 2.17E- 01 26.3 LYM14 8 12174. 1 H 29.3 6 1.27E- 02 89.1 LYM10 0 12133. 1 L 1.52 2.30E- 01 21.5 LYM31 11923. 4 H 22.0 07 1.51E- 02 41.8 LYM15 11612. 2 L 1.52 1 2.35E- 01 21.6 LYM17 0 12453. 2 H 19.3 73 2.87E- 02 24.8 LYM11 1 12251. 1 L 1.53 3 2.43E- 01 22.6 LYM69 11853. 5 H 20.5 73 3.39E- 02 32.5 LYM14 3 12524. 2 L 1.51 5 2.44E- 01 21.2 LYM29 0 12502. 4 H 22.4 69 3.42E- 02 44.7 LYM21 11673. 1 L 1.51 6 2.45E- 01 21.2 LYM13 0 12331. 3 H 18.9 05 3.44E- 02 21.8 LYM17 4 12411. 3 L 1.51 5 2.58E- 01 21.1 LYM13 7 12151. 1 H 21.7 62 3.90E- 02 40.2 LYM29 0 12502. 4 L 1.51 7 2.60E- 01 21.3 LYM53 11841. 1 H 22.5 4 5.42E- 02 45.2 LYM21 11672. 4 L 1.50 6 2.73E- 01 20.4 LYM51 11893. 2 H 18.8 76 6.70E- 02 21.6 LYM19 11754. 1 L 1.49 1 2.79E- 01 19.2 LYM13 8 12561. 3 H 23.0 75 7.08E- 02 48.7 LYM29 0 12501. 3 L 1.48 3 3.11E- 01 18.6 LYM14 8 12171. 2 H 21.1 07 7.50E- 02 36 LYM17 4 12412. 1 L 1.48 6 3.12E- 01 18.8 LYM11 9 12462. 2 H 19.8 45 8.05E- 02 27.8 LYM10 11744. 5 L 1.47 9 3.29E- 01 18.2 LYM57 12012. 2 H 18.1 27 8.18E- 02 16.8 LYM13 11771. 6 L 1.47 6 3.30E- 01 18 LYM11 9 12462. 1 H 25.6 04 8.45E- 02 64.9 2016213786 11 Aug 2016 321 Gene name Event I D Mea n P value % incr. vs. cont. Gene name Event I D Mea n P value % incr. vs. cont. LYM26 8 12483. 4 L 1.47 8 3.34E- 01 18.1 LYM14 12052. 4 H 18.1 08 9.10E- 02 16.7 LYM9 11632. 2 L 1.46 7 3.38E- 01 17.3 LYM68 11941. 3 H 21.3 83 9.75E- 02 37.7 LYM4 11705. 2 L 1.46 5 3.38E- 01 17.1 LYM43 11791. 4 H 20.1 59 1.06E- 01 29.9 LYM28 9 12491. 4 L 1.46 4 3.49E- 01 17 LYM13 7 12152. 1 H 17.8 11 1.18E- 01 14.7 LYM14 3 12521. 1 L 1.45 3 3.61E- 01 16.2 LYM10 5 12294. 3 H 18.8 02 1.43E- 01 21.1 LYM14 1 12404. 2 L 1.45 6 3.64E- 01 16.4 LYM11 1 12252. 2 H 35.5 94 1.61E- 01 129.3 LYM10 11742. 1 L 1.47 7 3.68E- 01 18.1 LYM30 11913. 5 H 19.9 62 1.68E- 01 28.6 LYM28 9 12493. 6 L 1.43 1 4.07E- 01 14.4 LYM26 8 12481. 1 H 18.4 91 1.73E- 01 19.1 LYM10 2 12221. 1 L 1.42 5 4.39E- 01 13.9 LYM13 0 12334. 1 H 17.4 32 1.74E- 01 12.3 LYM11 1 12252. 2 L 1.44 1 4.63E- 01 15.2 LYM14 8 12173. 1 H 18.3 18 1.82E- 01 18 LYM13 8 12562. 1 L 1.40 7 4.77E- 01 12.5 LYM68 11943. 2 H 20.4 73 1.93E- 01 31.9 LYM13 7 12153. 1 L 1.41 4 4.85E- 01 13.1 LYM13 7 12154. 5 H 19.4 06 2.03E- 01 25 LYM26 8 12482. 3 L 1.39 7 5.07E- 01 11.7 LYM15 2 12372. 2 H 17.7 21 2.08E- 01 14.2 LYM2 11692. 3 L 1.39 1 5.24E- 01 11.2 LYM10 0 12131. 3 H 17.3 47 2.10E- 01 11.7 LYM13 11772. 1 L 1.38 5 5.50E- 01 10.8 LYM10 5 12295. 2 H 18.6 36 2.16E- 01 20.1 LYM12 9 12573. 5 L 1.37 5.85E- 01 9.5 LYM13 0 12332. 2 H 19.3 96 2.39E- 01 25 LYM16 2 12233. 2 L 1.37 4 5.94E- 01 9.8 LYM29 0 12501. 3 H 18.1 76 2.41E- 01 17.1 LYM10 0 12131. 3 L 1.36 9 6.12E- 01 9.5 LYM17 2 12301. 2 H 19.4 01 2.45E- 01 25 LYM11 3 12442. 1 L 1.35 4 6.33E- 01 8.2 LYM68 11942. 2 H 18.8 4 2.53E- 01 21.4 LYM14 8 12172. 1 L 1.36 8 6.37E- 01 9.4 LYM62 12022. 1 H 18.1 31 2.65E- 01 16.8 LYM17 11681. 4 L 1.34 5 6.69E- 01 7.6 LYM57 12012. 6 H 17.8 54 2.67E- 01 15 LYM26 8 12482. 1 L 1.34 9 6.71E- 01 7.9 LYM11 1 12251. 3 H 19.2 31 2.86E- 01 23.9 LYM16 11624. 4 L 1.33 9 6.83E- 01 7.1 LYM11 1 12254. 4 H 19.7 09 2.89E- 01 27 LYM17 11684. 5 L 1.33 2 7.05E- 01 6.5 LYM51 11894. 2 H 17.1 23 3.01E- 01 10.3 LYM9 11633. 2 L 1.33 4 7.13E- 01 6.7 LYM30 11912. 6 H 20.5 01 3.16E- 01 32.1 LYM17 4 12414. 2 L 1.32 7.47E- 01 5.6 LYM53 11844. 2 H 20.1 69 3.27E- 01 29.9 2016213786 11 Aug 2016 322 Gene name Event I D Mea n P value % incr. vs. cont. Gene name Event I D Mea n P value % incr. vs. cont. LYM17 11683. 1 L 1.31 3 7.74E- 01 5 LYM13 2 12271. 4 H 17.7 65 3.38E- 01 14.4 LYM29 0 12502. 1 L 1.31 3 7.90E- 01 5 LYM62 12021. 1 H 19.7 79 3.40E- 01 27.4 LYM14 0 12261. 4 L 1.30 4 8.12E- 01 4.2 LYM13 7 12153. 1 H 16.7 96 3.54E- 01 8.2 LYM1 11601. 1 L 1.30 3 8.13E- 01 4.2 LYM10 0 12134. 1 H 17.7 39 3.54E- 01 14.3 LYM10 2 12222. 6 L 1.30 8 8.19E- 01 4.6 LYM15 2 12376. 1 H 18.5 14 3.63E- 01 19.3 LYM2 11693. 3 L 1.28 9 8.60E- 01 3 LYM51 11893. 4 H 22.5 79 3.83E- 01 45.5 LYM13 2 12275. 1 L 1.28 8 8.64E- 01 3 LYM10 0 12133. 3 H 16.6 99 4.07E- 01 7.6 LYM14 3 12521. 2 L 1.28 2 8.86E- 01 2.5 LYM14 3 12521. 2 H 16.5 83 4.25E- 01 6.8 LYM22 11762. 1 L 1.28 8.94E- 01 2.3 LYM11 1 12254. 3 H 22.3 09 4.38E- 01 43.7 LYM14 3 12523. 4 L 1.27 2 9.24E- 01 1.7 LYM14 12051. 4 H 17.1 86 4.39E- 01 10.7 LYM13 11771. 9 L 1.26 2 9.58E- 01 0.9 LYM15 2 12372. 1 H 20.5 78 4.63E- 01 32.6 LYM11 1 12254. 4 L 1.26 2 9.60E- 01 0.9 LYM14 3 12524. 7 H 23.4 43 4.73E- 01 51 LYM13 8 12564. 1 L 1.25 1 1.00E +00 0 LYM13 4 12312. 4 H 16.9 24 4.79E- 01 9 CONTR OL _ L 1.25 1 _ 0 LYM29 0 12502. 2 H 19.0 66 4.84E- 01 22.8 LYM1 11602. 6 M 0.31 3 3.40E- 05 94.2 LYM68 11941. 4 H 16.6 57 4.90E- 01 7.3 LYM10 11741. 2 M 0.30 1 6.50E- 05 86.3 LYM11 9 12461. 1 H 23.2 76 4.91E- 01 49.9 LYM11 9 12462. 2 M 0.27 4 1.29E- 03 69.7 LYM26 11824. 6 H 17.6 42 4.94E- 01 13.7 LYM9 11632. 1 M 0.26 7 1.64E- 03 65.3 LYM13 2 12275. 1 H 16.5 39 5.07E- 01 6.5 LYM14 3 12524. 7 M 0.26 2 1.85E- 03 62.2 LYM67 11783. 5 H 17.1 09 5.29E- 01 10.2 LYM14 8 12171. 2 M 0.25 4 3.03E- 03 57.5 LYM13 2 12276. 1 H 17.0 95 5.30E- 01 10.1 LYM13 8 12561. 1 M 0.25 5 3.74E- 03 58.1 LYM11 9 12461. 4 H 16.9 19 5.75E- 01 9 LYM17 4 12414. 3 M 0.24 1.42E- 02 48.8 LYM43 11792. 2 H 17.3 89 5.90E- 01 12 LYM1 11604. 4 M 0.23 2 1.88E- 02 43.5 LYM53 11842. 4 H 18.3 13 5.93E- 01 18 LYM13 0 12333. 1 M 0.23 3 2.02E- 02 44.7 LYM30 11912. 7 H 16.9 2 6.04E- 01 9 LYM10 2 12222. 2 M 0.23 1 2.03E- 02 43.1 LYM95 12124. 4 H 16.2 55 6.19E- 01 4.7 LYM28 9 12493. 2 M 0.23 3 2.20E- 02 44.7 LYM13 8 12562. 1 H 17.0 22 6.38E- 01 9.7 2016213786 11 Aug 2016 323 Gene name Event I D Mea n P value % incr. vs. cont. Gene name Event I D Mea n P value % incr. vs. cont. LYM14 8 12174. 1 M 0.23 2.25E- 02 42.5 LYM30 11913. 3 H 16.5 14 6.50E- 01 6.4 LYM14 1 12402. 4 M 0.23 2.54E- 02 42.6 LYM43 11793. 2 H 17.2 97 6.59E- 01 11.4 LYM11 9 12462. 1 M 0.23 2.88E- 02 42.6 LYM16 2 12231. 3 H 16.7 71 6.82E- 01 8 LYM13 8 12561. 3 M 0.22 8 3.48E- 02 41.2 LYM67 11782. 4 H 16.2 8 6.90E- 01 4.9 LYM10 11742. 2 M 0.22 4 3.55E- 02 39 LYM26 11824. 5 H 15.9 6 7.43E- 01 2.8 LYM1 11602. 1 M 0.22 4 3.66E- 02 38.8 LYM31 11922. 3 H 16.0 61 7.61E- 01 3.5 LYM10 5 12293. 1 M 0.22 2 4.23E- 02 37.6 LYM15 2 12371. 2 H 16.5 7 7.69E- 01 6.7 LYM17 4 12411. 2 M 0.22 2 4.59E- 02 37.7 LYM69 11852. 4 H 16.0 5 7.87E- 01 3.4 LYM16 2 12234. 4 M 0.23 4.82E- 02 42.4 LYM25 4 12474. 4 H 16.8 55 8.07E- 01 8.6 LYM10 11744. 1 M 0.21 9 4.91E- 02 35.7 LYM11 1 12251. 1 H 15.7 98 8.44E- 01 1.8 LYM15 2 12372. 2 M 0.21 8 5.92E- 02 35.1 LYM15 2 12373. 1 H 16.2 37 8.53E- 01 4.6 LYM16 2 12234. 3 M 0.21 8 6.16E- 02 34.9 LYM26 8 12483. 2 H 16.0 6 8.84E- 01 3.5 LYM4 11706. 5 M 0.21 6 6.18E- 02 34 LYM51 11891. 1 H 15.7 1 8.91E- 01 1.2 LYM15 11611. 3 M 0.22 1 7.09E- 02 36.8 LYM17 2 12302. 2 H 15.7 68 9.46E- 01 1.6 LYM13 0 12332. 2 M 0.21 5 8.05E- 02 33 LYM66 11954. 4 H 15.8 84 9.47E- 01 2.3 LYM19 11751. 5 M 0.21 2 8.99E- 02 31.1 LYM13 8 12564. 1 H 15.6 54 9.64E- 01 0.8 LYM15 11614. 3 M 0.21 9.28E- 02 29.8 LYM14 0 12262. 3 H 15.6 52 9.65E- 01 0.8 LYM11 9 12463. 2 M 0.20 9 1.02E- 01 29.8 LYM29 0 12502. 1 H 15.5 92 9.67E- 01 0.4 LYM13 2 12271. 4 M 0.20 9 1.03E- 01 29.8 LYM17 0 12452. 3 H 15.5 73 9.84E- 01 0.3 LYM14 0 12262. 3 M 0.20 7 1.08E- 01 28.5 LYM26 8 12482. 1 H 15.5 28 9.99E- 01 0 LYM15 11612. 3 M 0.20 9 1.11E- 01 29.7 CONTR OL _ H 15.5 23 _ 0 LYM28 9 12491. 1 M 0.21 1.13E- 01 30.3 LYM11 1 12252. 2 J 0.07 5 6.99E- 04 88 LYM13 0 12334. 1 M 0.20 7 1.15E- 01 28.5 LYM14 8 12174. 1 J 0.06 1.71E- 02 51.2 LYM19 11751. 4 M 0.21 1.16E- 01 30.4 LYM10 0 12131. 2 J 0.05 7 3.78E- 02 43.8 LYM19 11753. 1 M 0.20 3 1.46E- 01 25.9 LYM11 9 12462. 1 J 0.05 7 4.39E- 02 42.8 LYM13 4 12311. 2 M 0.20 5 1.46E- 01 27 LYM13 4 12314. 2 J 0.05 6 5.26E- 02 40.2 2016213786 11 Aug 2016 324 Gene name Event I D Mea n P value % incr. vs. cont. Gene name Event I D Mea n P value % incr. vs. cont. LYM16 2 12231. 1 M 0.20 5 1.48E- 01 26.8 LYM13 8 12561. 1 J 0.05 6 5.33E- 02 40.8 LYM13 2 12273. 2 M 0.20 2 1.51E- 01 25.4 LYM53 11841. 1 J 0.05 3 l.OOE- 01 33.8 LYM1 11603. 2 M 0.20 2 1.55E- 01 25 LYM11 9 12461. 1 J 0.05 5 1.12E- 01 39 LYM11 9 12461. 4 M 0.20 2 1.59E- 01 24.9 LYM43 11791. 5 J 0.05 2 1.28E- 01 30.7 LYM14 8 12173. 1 M 0.20 5 1.64E- 01 26.9 LYM14 3 12524. 2 J 0.05 2 1.29E- 01 30.9 LYM17 11684. 4 M 0.20 1 1.64E- 01 24.6 LYM13 8 12561. 3 J 0.05 2 1.37E- 01 31 LYM14 1 12404. 4 M 0.19 9 1.99E- 01 23.6 LYM26 8 12482. 3 J 0.05 2 1.50E- 01 29.7 LYM10 2 12222. 3 M 0.20 2 2.01E- 01 25.1 LYM51 11893. 4 J 0.05 2 1.68E- 01 31.2 LYM17 4 12412. 1 M 0.20 1 2.06E- 01 24.5 LYM17 0 12453. 2 J 0.05 1.80E- 01 26.5 LYM26 8 12483. 2 M 0.19 6 2.14E- 01 21.6 LYM14 8 12171. 2 J 0.05 1.84E- 01 25.8 LYM16 2 12231. 3 M 0.19 6 2.16E- 01 21.8 LYM29 0 12502. 4 J 0.05 1 1.91E- 01 27.3 LYM4 11705. 2 M 0.19 7 2.21E- 01 22.2 LYM69 11853. 5 J 0.05 1.99E- 01 25.8 LYM15 2 12371. 2 M 0.19 6 2.42E- 01 21.5 LYM14 3 12524. 7 J 0.05 2 2.03E- 01 30.5 LYM14 1 12404. 3 M 0.19 5 2.46E- 01 20.8 LYM15 2 12372. 1 J 0.05 1 2.08E- 01 27.9 LYM21 11671. 2 M 0.19 4 2.63E- 01 19.9 LYM31 11923. 4 J 0.04 9 2.30E- 01 23.8 LYM9 11633. 7 M 0.19 4 2.66E- 01 20.2 LYM62 12021. 1 J 0.04 9 2.47E- 01 23.5 LYM17 11682. 1 M 0.19 6 2.76E- 01 21.7 LYM68 11941. 3 J 0.04 9 2.49E- 01 22.7 LYM10 5 12294. 2 M 0.19 7 2.79E- 01 22.4 LYM68 11942. 3 J 0.04 9 2.51E- 01 22.9 LYM10 0 12133. 1 M 0.19 3.08E- 01 17.7 LYM30 11912. 6 J 0.04 9 2.52E- 01 23.6 LYM15 11612. 2 M 0.19 3.12E- 01 17.8 LYM13 7 12151. 1 J 0.04 9 2.56E- 01 23 LYM11 1 12251. 1 M 0.19 2 3.17E- 01 18.8 LYM11 1 12254. 3 J 0.05 2.65E- 01 26.4 LYM14 3 12524. 2 M 0.18 9 3.24E- 01 17.4 LYM13 7 12154. 5 J 0.04 9 2.67E- 01 22.6 LYM21 11673. 1 M 0.19 3.25E- 01 17.4 LYM43 11791. 4 J 0.04 7 3.56E- 01 18.4 LYM17 4 12411. 3 M 0.18 9 3.38E- 01 17.3 LYM57 12013. 5 J 0.04 7 3.61E- 01 17.9 LYM29 0 12502. 4 M 0.19 3.39E- 01 17.5 LYM53 11844. 2 J 0.04 7 3.67E- 01 18.8 LYM21 11672. 4 M 0.18 8 3.57E- 01 16.6 LYM30 11913. 5 J 0.04 7 3.74E- 01 18.1 2016213786 11 Aug 2016 325 Gene name Event I D Mea n P value % incr. vs. cont. Gene name Event I D Mea n P value % incr. vs. cont. LYM19 11754. 1 M 0.18 6 3.68E- 01 15.5 LYM17 2 12301. 2 J 0.04 7 3.74E- 01 17.8 LYM29 0 12501. 3 M 0.18 5 4.02E- 01 14.9 LYM14 0 12264. 1 J 0.04 6 4.03E- 01 16.5 LYM10 11744. 5 M 0.18 5 4.23E- 01 14.5 LYM11 1 12251. 3 J 0.04 6 4.13E- 01 16.2 LYM13 11771. 6 M 0.18 4 4.24E- 01 14.3 LYM10 5 12294. 3 J 0.04 6 4.21E- 01 15.8 LYM26 8 12483. 4 M 0.18 5 4.28E- 01 14.5 LYM11 9 12462. 2 J 0.04 6 4.34E- 01 16.2 LYM9 11632. 2 M 0.18 3 4.36E- 01 13.6 LYM29 0 12502. 2 J 0.04 7 4.34E- 01 16.7 LYM28 9 12491. 4 M 0.18 3 4.48E- 01 13.4 LYM68 11943. 2 J 0.04 6 4.46E- 01 15 LYM10 11742. 1 M 0.18 5 4.60E- 01 14.4 LYM26 8 12481. 1 J 0.04 6 4.64E- 01 14.3 LYM14 3 12521. 1 M 0.18 2 4.66E- 01 12.6 LYM13 7 12153. 1 J 0.04 6 4.66E- 01 14.7 LYM14 1 12404. 2 M 0.18 2 4.66E- 01 12.7 LYM13 7 12152. 1 J 0.04 6 4.76E- 01 14.3 LYM28 9 12493. 6 M 0.17 9 5.20E- 01 10.9 LYM11 1 12254. 4 J 0.04 5 5.19E- 01 12.8 LYM17 11681. 4 M 0.17 9 5.21E- 01 11 LYM67 11783. 5 J 0.04 5 5.24E- 01 13.1 LYM10 2 12221. 1 M 0.17 8 5.52E- 01 10.4 LYM14 12052. 4 J 0.04 5 5.38E- 01 12 LYM11 1 12252. 2 M 0.18 5.64E- 01 11.6 LYM15 2 12376. 1 J 0.04 5 5.55E- 01 11.7 LYM13 8 12562. 1 M 0.17 6 5.99E- 01 9 LYM57 12012. 2 J 0.04 4 5.56E- 01 11.6 LYM13 7 12153. 1 M 0.17 7 5.99E- 01 9.6 LYM43 11792. 2 J 0.04 5 5.60E- 01 11.9 LYM26 8 12482. 3 M 0.17 5 6.31E- 01 8.3 LYM68 11942. 2 J 0.04 4 6.17E- 01 9.8 LYM2 11692. 3 M 0.17 4 6.50E- 01 7.8 LYM13 4 12312. 4 J 0.04 3 6.74E- 01 8.3 LYM13 11772. 1 M 0.17 3 6.76E- 01 7.3 LYM13 8 12562. 1 J 0.04 3 6.85E- 01 7.9 LYM12 9 12573. 5 M 0.17 1 7.18E- 01 6.1 LYM10 5 12295. 2 J 0.04 3 6.88E- 01 7.9 LYM16 2 12233. 2 M 0.17 2 7.20E- 01 6.4 LYM15 2 12372. 2 J 0.04 3 6.89E- 01 7.7 LYM10 0 12131. 3 M 0.17 1 7.38E- 01 6.1 LYM25 4 12474. 4 J 0.04 3 7.03E- 01 8.3 LYM14 8 12172. 1 M 0.17 1 7.57E- 01 6 LYM51 11893. 2 J 0.04 3 7.27E- 01 6.7 LYM11 3 12442. 1 M 0.16 9 7.72E- 01 4.9 LYM57 12012. 6 J 0.04 3 7.31E- 01 6.8 LYM26 8 12482. 1 M 0.16 9 8.03E- 01 4.5 LYM11 9 12461. 4 J 0.04 3 7.38E- 01 6.7 LYM16 11624. 4 M 0.16 7 8.24E- 01 3.7 LYM10 0 12134. 1 J 0.04 2 7.60E- 01 6 2016213786 11 Aug 2016 326 Gene name Event I D Mea n P value % incr. vs. cont. Gene name Event I D Mea n P value % incr. vs. cont. LYM17 11684. 5 M 0.16 7 8.48E- 01 3.2 LYM13 2 12276. 1 J 0.04 2 7.61E- 01 5.8 LYM9 11633. 2 M 0.16 7 8.49E- 01 3.4 LYM29 0 12501. 3 J 0.04 2 7.65E- 01 5.8 LYM17 4 12414. 2 M 0.16 5 8.92E- 01 2.3 LYM62 12022. 1 J 0.04 2 7.73E- 01 5.6 LYM17 11683. 1 M 0.16 4 9.20E- 01 1.7 LYM26 11824. 6 J 0.04 2 7.80E- 01 5.3 LYM29 0 12502. 1 M 0.16 4 9.25E- 01 1.7 LYM51 11891. 1 J 0.04 2 8.08E- 01 4.6 LYM10 2 12222. 6 M 0.16 3 9.46E- 01 1.3 LYM43 11793. 2 J 0.04 2 8.24E- 01 4.5 LYM14 0 12261. 4 M 0.16 3 9.55E- 01 1 LYM10 0 12131. 3 J 0.04 1 8.31E- 01 4 LYM1 11601. 1 M 0.16 3 9.57E- 01 0.9 LYM14 3 12521. 2 J 0.04 1 8.39E- 01 3.9 CONTR OL _ M 0.16 1 _ 0 LYM13 2 12275. 1 J 0.04 1 8.53E- 01 3.6 LYM10 11741. 2 N 0.27 4 1.39E- 04 51 LYM10 0 12133. 3 J 0.04 1 8.80E- 01 2.9 LYM9 11632. 1 N 0.27 2 1.71E- 04 49.7 LYM51 11894. 2 J 0.04 1 8.81E- 01 2.9 LYM1 11602. 6 N 0.27 1.78E- 04 48.6 LYM67 11782. 4 J 0.04 1 8.84E- 01 2.9 LYM14 3 12524. 7 N 0.26 7 4.23E- 04 46.9 LYM14 12051. 4 J 0.04 1 8.90E- 01 2.7 LYM11 9 12462. 2 N 0.25 2 5.22E- 03 38.9 LYM53 11842. 4 J 0.04 1 9.19E- 01 2.1 LYM10 11742. 2 N 0.23 6 1.12E- 02 29.9 LYM17 2 12302. 2 J 0.04 9.57E- 01 1.1 LYM28 9 12493. 2 N 0.23 5 1.37E- 02 29.4 LYM13 0 12331. 3 J 0.04 9.66E- 01 0.8 LYM17 4 12414. 3 N 0.23 8 1.53E- 02 30.8 LYM26 8 12482. 1 J 0.04 9.71E- 01 0.7 LYM14 8 12171. 2 N 0.23 4 1.54E- 02 29 LYM13 2 12271. 4 J 0.04 9.73E- 01 0.7 LYM10 5 12293. 1 N 0.23 3 1.86E- 02 28 LYM16 2 12231. 3 J 0.04 9.76E- 01 0.6 LYM13 8 12561. 1 N 0.23 5 1.90E- 02 29.3 LYM14 12051. 1 J 0.04 9.76E- 01 0.6 LYM10 2 12222. 2 N 0.23 1 2.04E- 02 27.3 LYM30 11912. 7 J 0.04 9.77E- 01 0.6 LYM14 8 12174. 1 N 0.23 2.20E- 02 26.7 LYM69 11854. 2 J 0.04 9.77E- 01 0.5 LYM13 0 12333. 1 N 0.23 2 2.21E- 02 27.5 LYM15 2 12373. 1 J 0.04 9.81E- 01 0.5 LYM16 2 12234. 3 N 0.23 1 2.61E- 02 27.1 LYM14 8 12173. 1 J 0.04 9.85E- 01 0.4 LYM1 11604. 4 N 0.23 2.80E- 02 26.7 CONTR OL _ J 0.04 _ 0 LYM15 11614. 3 N 0.22 7 3.23E- 02 25.2 LYM67 11783. 5 K 0.74 1 6.72E- 04 44.8 2016213786 11 Aug 2016 327 Gene name Event I D Mea n P value % incr. vs. cont. Gene name Event I D Mea n P value % incr. vs. cont. LYM15 2 12372. 2 N 0.22 8 3.31E- 02 25.6 LYM13 2 12276. 1 K 0.69 6 1.12E- 02 36 LYM16 2 12234. 4 N 0.23 6 3.39E- 02 30 LYM13 8 12566. 1 K 0.65 9 1.33E- 02 28.9 LYM14 1 12402. 4 N 0.22 6 4.06E- 02 24.5 LYM11 9 12461. 1 K 0.67 1 1.72E- 02 31.2 LYM13 4 12311. 2 N 0.22 6 4.65E- 02 24.2 LYM69 11853. 5 K 0.65 7 2.56E- 02 28.4 LYM19 11751. 5 N 0.22 3 4.82E- 02 22.9 LYM13 7 12151. 1 K 0.64 8 2.68E- 02 26.8 LYM10 11744. 1 N 0.22 4 4.91E- 02 23.5 LYM13 8 12561. 1 K 0.63 8 3.91E- 02 24.7 LYM1 11602. 1 N 0.22 4 5.06E- 02 23.2 LYM10 5 12297. 1 K 0.64 6 4.88E- 02 26.3 LYM13 2 12271. 4 N 0.22 1 5.78E- 02 21.8 LYM30 11913. 3 K 0.63 1 5.27E- 02 23.3 LYM17 4 12411. 2 N 0.22 3 5.88E- 02 22.8 LYM53 11841. 1 K 0.64 1 5.90E- 02 25.3 LYM14 0 12262. 3 N 0.22 1 6.40E- 02 21.4 LYM11 1 12251. 1 K 0.62 7 6.03E- 02 22.5 LYM11 9 12461. 4 N 0.22 7.17E- 02 21.3 LYM24 12061. 2 K 0.63 1 6.18E- 02 23.3 LYM4 11706. 5 N 0.21 9 8.19E- 02 20.4 LYM24 12064. 1 K 0.61 8 6.89E- 02 20.9 LYM15 11611. 3 N 0.22 4 8.23E- 02 23.1 LYM25 4 12471. 2 K 0.61 5 7.20E- 02 20.3 LYM13 0 12332. 2 N 0.22 2 8.28E- 02 22.3 LYM31 11923. 1 K 0.61 7 8.28E- 02 20.6 LYM26 8 12483. 2 N 0.21 7 9.09E- 02 19.5 LYM57 12013. 5 K 0.61 7 8.35E- 02 20.7 LYM17 4 12412. 1 N 0.22 9.27E- 02 20.8 LYM10 5 12295. 2 K 0.62 8.37E- 02 21.2 LYM16 2 12231. 1 N 0.21 7 1.07E- 01 19.4 LYM10 5 12293. 1 K 0.61 1 8.53E- 02 19.5 LYM19 11751. 4 N 0.21 8 1.07E- 01 19.8 LYM51 11893. 2 K 0.62 8.98E- 02 21.3 LYM13 8 12561. 3 N 0.21 7 1.08E- 01 19.3 LYM62 12022. 1 K 0.61 2 9.67E- 02 19.7 LYM14 1 12404. 4 N 0.21 7 1.08E- 01 19.3 LYM68 11942. 3 K 0.60 5 1.06E- 01 18.2 LYM19 11753. 1 N 0.21 4 1.09E- 01 18.1 LYM14 8 12174. 1 K 0.61 5 1.1 OE-01 20.3 LYM17 4 12411. 3 N 0.21 7 1.15E- 01 19.2 LYM11 1 12254. 4 K 0.61 4 1.13E- 01 20.1 LYM13 2 12273. 2 N 0.21 3 1.19E- 01 17.4 LYM26 8 12482. 3 K 0.61 6 1.16E- 01 20.4 LYM17 11684. 4 N 0.21 4 1.19E- 01 17.9 LYM11 1 12252. 2 K 0.60 9 1.28E- 01 19.1 LYM4 11705. 2 N 0.21 5 1.21E- 01 18.1 LYM67 11782. 5 K 0.60 2 1.28E- 01 17.6 LYM15 11612. 3 N 0.21 7 1.25E- 01 19.3 LYM62 12023. 4 K 0.60 6 1.29E- 01 18.4 2016213786 11 Aug 2016 328 Gene name Event I D Mea n P value % incr. vs. cont. Gene name Event I D Mea n P value % incr. vs. cont. LYM9 11632. 2 N 0.21 5 1.26E- 01 18.3 LYM14 8 12172. 1 K 0.60 1 1.35E- 01 17.5 LYM11 9 12462. 1 N 0.21 6 1.29E- 01 18.6 LYM14 3 12524. 2 K 0.60 5 1.51E- 01 18.2 LYM21 11673. 1 N 0.21 3 1.36E- 01 17.4 LYM13 8 12564. 1 K 0.61 6 1.54E- 01 20.4 LYM29 0 12501. 3 N 0.21 6 1.42E- 01 18.7 LYM13 4 12311. 2 K 0.59 9 1.66E- 01 17.1 LYM13 0 12334. 1 N 0.21 3 1.48E- 01 17.3 LYM26 11824. 6 K 0.60 2 1.76E- 01 17.6 LYM17 11682. 1 N 0.21 7 1.52E- 01 19.2 LYM29 0 12504. 1 K 0.59 6 1.83E- 01 16.5 LYM16 2 12231. 3 N 0.21 1 1.58E- 01 16.2 LYM95 12124. 4 K 0.59 1 1.85E- 01 15.5 LYM10 0 12133. 1 N 0.21 1.59E- 01 15.8 LYM15 3 12321. 2 K 0.59 5 1.94E- 01 16.4 LYM19 11754. 1 N 0.21 1 1.60E- 01 15.9 LYM17 0 12453. 2 K 0.58 5 2.40E- 01 14.3 LYM14 8 12173. 1 N 0.21 4 1.61E- 01 17.8 LYM30 11913. 5 K 0.58 5 2.41E- 01 14.3 LYM13 7 12153. 1 N 0.21 1.80E- 01 15.8 LYM11 9 12462. 2 K 0.58 6 2.44E- 01 14.7 LYM13 8 12562. 1 N 0.20 8 1.95E- 01 14.6 LYM14 3 12524. 7 K 0.6 2.47E- 01 17.4 LYM10 2 12221. 1 N 0.20 8 1.97E- 01 14.5 LYM17 2 12302. 2 K 0.57 8 2.79E- 01 13 LYM15 11612. 2 N 0.20 8 2.06E- 01 14.6 LYM68 11943. 2 K 0.58 3 2.80E- 01 14 LYM13 11772. 1 N 0.20 9 2.08E- 01 14.9 LYM13 2 12275. 1 K 0.58 5 2.80E- 01 14.3 LYM1 11601. 1 N 0.20 9 2.18E- 01 15.2 LYM66 11955. 2 K 0.57 5 2.85E- 01 12.4 LYM14 3 12521. 1 N 0.20 7 2.19E- 01 14 LYM29 0 12502. 2 K 0.57 7 2.87E- 01 12.8 LYM15 2 12371. 2 N 0.20 8 2.27E- 01 14.5 LYM14 0 12261. 1 K 0.59 8 2.92E- 01 16.8 LYM28 9 12491. 4 N 0.20 6 2.34E- 01 13.6 LYM29 0 12502. 1 K 0.57 8 2.94E- 01 13 LYM1 11603. 2 N 0.20 5 2.45E- 01 13 LYM13 4 12314. 2 K 0.57 5 2.95E- 01 12.4 LYM26 8 12483. 4 N 0.20 8 2.49E- 01 14.4 LYM62 12021. 1 K 0.57 9 3.02E- 01 13.2 LYM21 11672. 4 N 0.20 7 2.55E- 01 14 LYM14 12052. 5 K 0.57 4 3.05E- 01 12.2 LYM28 9 12493. 6 N 0.20 5 2.58E- 01 12.7 LYM95 12121. 2 K 0.57 3 3.13E- 01 12 LYM21 11671. 2 N 0.20 6 2.59E- 01 13.3 LYM26 8 12481. 1 K 0.57 5 3.22E- 01 12.5 LYM11 1 12251. 1 N 0.20 7 2.60E- 01 13.9 LYM69 11854. 2 K 0.57 3.32E- 01 11.5 LYM11 9 12463. 2 N 0.20 5 2.61E- 01 12.9 LYM62 12022. 2 K 0.57 4 3.34E- 01 12.2 2016213786 11 Aug 2016 329 Gene name Event I D Mea n P value % incr. vs. cont. Gene name Event I D Mea n P value % incr. vs. cont. LYM10 11744. 5 N 0.20 6 2.65E- 01 13.5 LYM30 11912. 7 K 0.57 4 3.35E- 01 12.3 LYM14 8 12172. 1 N 0.20 9 2.78E- 01 15 LYM69 11853. 4 K 0.57 8 3.42E- 01 13 LYM14 1 12404. 2 N 0.20 3 2.88E- 01 11.9 LYM13 2 12275. 3 K 0.56 9 3.42E- 01 11.2 LYM13 11771. 6 N 0.20 5 2.89E- 01 12.6 LYM13 0 12333. 1 K 0.56 5 3.66E- 01 10.6 LYM14 1 12404. 3 N 0.20 4 2.94E- 01 12.1 LYM10 5 12294. 2 K 0.56 3 3.67E- 01 10.1 LYM10 2 12222. 3 N 0.20 7 3.08E- 01 14.2 LYM31 11922. 3 K 0.56 7 3.69E- 01 10.8 LYM28 9 12491. 1 N 0.20 6 3.10E- 01 13.2 LYM17 0 12453. 3 K 0.56 8 3.72E- 01 11.1 LYM17 11681. 4 N 0.20 2 3.14E- 01 11.3 LYM25 4 12473. 1 K 0.56 3 4.05E- 01 10 LYM26 8 12482. 3 N 0.20 3 3.18E- 01 11.5 LYM31 11924. 4 K 0.57 4.08E- 01 11.4 LYM16 2 12233. 2 N 0.20 2 3.39E- 01 11.3 LYM15 2 12376. 1 K 0.56 4 4.22E- 01 10.3 LYM17 4 12414. 2 N 0.20 1 3.47E- 01 10.8 LYM57 12012. 2 K 0.56 5 4.26E- 01 10.4 LYM16 11624. 4 N 0.2 3.59E- 01 10.2 LYM14 12051. 4 K 0.56 4.29E- 01 9.5 LYM12 9 12573. 5 N 0.2 3.63E- 01 10.2 LYM14 0 12261. 4 K 0.55 7 4.32E- 01 9 LYM29 0 12502. 4 N 0.20 2 3.73E- 01 11.1 LYM13 0 12334. 1 K 0.55 8 4.46E- 01 9.1 LYM26 8 12482. 1 N 0.19 8 4.54E- 01 9 LYM13 7 12154. 5 K 0.55 6 4.67E- 01 8.7 LYM10 5 12294. 2 N 0.2 4.70E- 01 10 LYM10 0 12131. 3 K 0.55 7 4.69E- 01 9 LYM13 2 12275. 3 N 0.2 4.79E- 01 10 LYM53 11841. 2 K 0.55 8 4.74E- 01 9.2 LYM19 11752. 2 N 0.19 7 4.82E- 01 8.5 LYM26 8 12483. 4 K 0.56 5 4.77E- 01 10.4 LYM14 3 12524. 2 N 0.19 6 4.88E- 01 7.8 LYM68 11941. 3 K 0.55 5 4.80E- 01 8.6 LYM9 11633. 7 N 0.19 6 4.90E- 01 8.1 LYM17 0 12452. 4 K 0.55 9 4.81E- 01 9.3 LYM15 3 12321. 2 N 0.19 6 5.19E- 01 7.7 LYM14 8 12173. 1 K 0.55 5 4.86E- 01 8.5 LYM11 1 12254. 4 N 0.19 5 5.30E- 01 7.1 LYM26 8 12482. 1 K 0.55 8 4.94E- 01 9.1 LYM13 2 12275. 1 N 0.19 4 5.34E- 01 7 LYM26 11821. 2 K 0.56 5.00E- 01 9.4 LYM14 3 12521. 2 N 0.19 4 5.39E- 01 6.9 LYM31 11921. 3 K 0.55 8 5.05E- 01 9.1 LYM10 11742. 1 N 0.19 6 5.54E- 01 7.8 LYM31 11923. 4 K 0.55 4 5.08E- 01 8.3 LYM10 2 12222. 6 N 0.19 6 5.56E- 01 7.9 LYM15 3 12322. 1 K 0.56 5.10E- 01 9.5 2016213786 11 Aug 2016 330 Gene name Event I D Mea n P value % incr. vs. cont. Gene name Event I D Mea n P value % incr. vs. cont. LYM13 11771. 9 N 0.19 3 5.98E- 01 6.2 LYM30 11913. 4 K 0.54 9 5.23E- 01 7.4 LYM11 3 12442. 1 N 0.19 2 6.01E- 01 5.9 LYM53 11844. 2 K 0.55 2 5.40E- 01 7.9 LYM2 11693. 3 N 0.19 2 6.18E- 01 5.7 LYM13 8 12561. 3 K 0.55 1 5.44E- 01 7.7 LYM14 0 12261. 4 N 0.19 1 6.66E- 01 4.9 LYM15 2 12372. 1 K 0.55 2 5.48E- 01 7.9 LYM16 11622. 2 N 0.19 6.70E- 01 4.8 LYM24 12061. 4 K 0.54 8 5.49E- 01 7.2 LYM13 0 12331. 3 N 0.18 9 7.24E- 01 4.2 LYM17 2 12304. 2 K 0.55 2 5.50E- 01 7.8 LYM10 0 12131. 3 N 0.18 9 7.44E- 01 3.9 LYM14 8 12174. 2 K 0.55 2 5.65E- 01 7.9 LYM2 11692. 3 N 0.18 8 7.48E- 01 3.6 LYM25 4 12474. 3 K 0.55 5.67E- 01 7.6 LYM13 8 12564. 1 N 0.18 8 7.56E- 01 3.5 LYM51 11891. 1 K 0.54 3 5.74E- 01 6.2 LYM11 1 12252. 2 N 0.18 9 7.61E- 01 4.2 LYM15 2 12371. 2 K 0.54 8 5.75E- 01 7.2 LYM10 6 12141. 4 N 0.18 8 7.62E- 01 3.5 LYM43 11793. 2 K 0.55 5.77E- 01 7.6 LYM14 1 12404. 1 N 0.18 7 7.90E- 01 3 LYM15 2 12373. 1 K 0.55 5.98E- 01 7.6 LYM28 9 12492. 2 N 0.18 7 8.07E- 01 2.9 LYM25 4 12474. 4 K 0.54 6 6.00E- 01 6.7 LYM15 3 12324. 2 N 0.18 7 8.23E- 01 2.9 LYM67 11781. 5 K 0.54 2 6.09E- 01 6 LYM17 11684. 5 N 0.18 5 8.58E- 01 2 LYM43 11791. 5 K 0.54 5 6.10E- 01 6.6 LYM11 9 12461. 1 N 0.18 5 8.84E- 01 1.7 LYM51 11892. 1 K 0.54 3 6.25E- 01 6.2 LYM14 3 12523. 4 N 0.18 5 8.92E- 01 1.6 LYM10 0 12131. 2 K 0.54 1 6.31E- 01 5.8 LYM9 11633. 2 N 0.18 4 9.21E- 01 1.3 LYM14 3 12521. 2 K 0.53 9 6.33E- 01 5.4 LYM17 11683. 1 N 0.18 3 9.35E- 01 0.9 LYM16 2 12231. 1 K 0.53 9 6.33E- 01 5.4 LYM10 6 12142. 2 N 0.18 2 9.73E- 01 0.4 LYM14 3 12521. 1 K 0.53 9 6.47E- 01 5.4 LYM22 11764. 1 N 0.18 2 9.75E- 01 0.4 LYM67 11782. 6 K 0.53 9 6.49E- 01 5.4 LYM22 11762. 1 N 0.18 2 9.78E- 01 0.3 LYM53 11843. 2 K 0.54 6.70E- 01 5.5 LYM14 0 12264. 1 N 0.18 2 9.80E- 01 0.3 LYM26 11824. 5 K 0.53 6 6.75E- 01 4.7 LYM15 3 12323. 2 N 0.18 2 9.81E- 01 0.3 LYM13 0 12332. 1 K 0.54 2 6.78E- 01 5.9 LYM10 6 12144. 4 N 0.18 2 9.82E- 01 0.3 LYM66 11952. 1 K 0.53 5 6.92E- 01 4.6 LYM10 5 12294. 3 N 0.18 2 9.87E- 01 0.2 LYM10 0 12133. 3 K 0.53 3 7.11E- 01 4.2 2016213786 11 Aug 2016 331 Gene name Event I D Mea n P value % incr. vs. cont. Gene name Event I D Mea n P value % incr. vs. cont. CONTR OL _ N 0.18 2 _ 0 LYM29 0 12502. 4 K 0.53 4 7.21E- 01 4.4 LYM14 3 12524. 7 O 2.00 8 1.50E- 05 58.2 LYM16 2 12234. 3 K 0.53 3 7.24E- 01 4.2 LYM14 8 12171. 2 O 2.01 4 2.00E- 05 58.6 LYM17 4 12414. 3 K 0.53 3 7.34E- 01 4.2 LYM13 0 12333. 1 o 1.85 1 7.90E- 05 45.8 LYM14 3 12523. 4 K 0.53 2 7.42E- 01 3.9 LYM10 11741. 2 o 2.33 9 1.39E- 04 84.2 LYM14 12051. 1 K 0.53 1 7.52E- 01 3.8 LYM4 11706. 5 o 1.75 9 2.95E- 04 38.5 LYM14 0 12262. 3 K 0.53 1 7.59E- 01 3.8 LYM10 2 12222. 2 o 1.76 1 3.14E- 04 38.7 LYM24 12063. 3 K 0.52 9 7.68E- 01 3.5 LYM1 11602. 1 o 1.74 7 3.45E- 04 37.5 LYM43 11791. 4 K 0.53 7.70E- 01 3.7 LYM10 5 12293. 1 o 1.73 5 4.36E- 04 36.6 LYM14 8 12171. 2 K 0.52 9 7.79E- 01 3.4 LYM10 11744. 1 o 1.73 1 4.44E- 04 36.3 LYM51 11894. 2 K 0.52 9 7.80E- 01 3.5 LYM16 2 12234. 3 o 1.69 6 6.35E- 04 33.6 LYM17 4 12411. 3 K 0.52 7 8.03E- 01 3 LYM14 0 12262. 3 o 1.62 2.10E- 03 27.6 LYM15 3 12323. 2 K 0.52 7 8.05E- 01 3 LYM13 2 12271. 4 o 1.61 8 2.28E- 03 27.4 LYM26 8 12483. 2 K 0.52 6 8.15E- 01 2.9 LYM15 11614. 3 o 1.61 1 2.52E- 03 26.9 LYM16 2 12231. 3 K 0.52 7 8.18E- 01 3 LYM15 2 12372. 2 o 1.69 8.69E- 03 33.1 LYM13 4 12313. 2 K 0.52 3 8.47E- 01 2.3 LYM1 11602. 6 o 2.43 5 9.41E- 03 91.7 LYM13 7 12151. 2 K 0.52 3 8.53E- 01 2.3 LYM11 9 12461. 4 o 1.55 2 1.28E- 02 22.2 LYM14 12054. 2 K 0.52 2 8.56E- 01 2.1 LYM13 2 12273. 2 o 1.61 5 1.84E- 02 27.2 LYM13 2 12271. 4 K 0.52 2 8.70E- 01 2 LYM13 0 12334. 1 o 1.63 2.12E- 02 28.4 LYM26 11824. 3 K 0.52 8.83E- 01 1.7 LYM10 0 12133. 1 o 1.49 9 2.74E- 02 18.1 LYM68 11942. 2 K 0.52 8.89E- 01 1.6 LYM28 9 12493. 2 o 1.81 8 3.54E- 02 43.2 LYM13 4 12312. 3 K 0.51 9 9.12E- 01 1.4 LYM16 2 12231. 3 o 1.52 6 3.61E- 02 20.2 LYM57 12012. 6 K 0.51 9 9.13E- 01 1.4 LYM11 9 12463. 2 o 1.66 6 4.22E- 02 31.2 LYM68 11941. 4 K 0.51 8 9.13E- 01 1.3 LYM13 8 12561. 1 o 2.01 6 5.07E- 02 58.8 LYM95 12124. 5 K 0.51 8 9.25E- 01 1.2 LYM17 11684. 4 o 1.54 6 5.44E- 02 21.7 LYM10 0 12133. 1 K 0.51 7 9.31E- 01 1 LYM1 11603. 2 o 1.58 4 5.79E- 02 24.8 LYM11 9 12461. 4 K 0.51 6 9.42E- 01 1 2016213786 11 Aug 2016 332 Gene name Event I D Mea n P value % incr. vs. cont. Gene name Event I D Mea n P value % incr. vs. cont. LYM14 1 12404. 2 O 1.43 4 7.37E- 02 13 LYM15 2 12372. 2 K 0.51 4 9.65E- 01 0.5 LYM19 11751. 5 o 1.66 4 1.05E- 01 31 LYM14 0 12264. 1 K 0.51 4 9.70E- 01 0.5 LYM26 8 12483. 2 o 1.50 2 1.15E- 01 18.3 LYM57 12013. 3 K 0.51 4 9.72E- 01 0.4 LYM9 11632. 1 o 2.06 9 1.20E- 01 63 LYM13 7 12152. 1 K 0.51 3 9.74E- 01 0.4 LYM28 9 12493. 6 o 1.40 3 1.25E- 01 10.5 LYM30 11912. 6 K 0.51 3 9.76E- 01 0.4 LYM1 11604. 4 o 1.81 6 1.26E- 01 43 LYM3 12041. 1 K 0.51 3 9.85E- 01 0.3 LYM14 8 12174. 1 o 1.81 1 1.28E- 01 42.6 LYM11 9 12462. 1 K 0.51 2 9.90E- 01 0.2 LYM14 1 12402. 4 o 1.8 1.35E- 01 41.8 LYM26 11824. 1 K 0.51 2 9.97E- 01 0 LYM10 11742. 2 o 1.74 1 1.42E- 01 37.1 LYM62 12022. 4 K 0.51 2 9.97E- 01 0 LYM13 11771. 6 o 1.45 1.49E- 01 14.2 LYM10 5 12294. 3 K 0.51 2 9.97E- 01 0 LYM11 9 12462. 2 o 2.12 7 1.57E- 01 67.5 CONTR OL _ K 0.51 1 _ 0 LYM10 2 12221. 1 o 1.39 2 1.62E- 01 9.6 LYM11 1 12252. 2 L 4.3 3.60E- 05 126.4 LYM19 11753. 1 o 1.58 6 1.69E- 01 24.9 LYM14 8 12174. 1 L 3.57 9 4.94E- 04 88.4 LYM9 11632. 2 o 1.42 4 1.70E- 01 12.1 LYM11 9 12462. 1 L 3.12 5 7.46E- 03 64.5 LYM17 4 12411. 2 o 1.75 3 1.79E- 01 38.1 LYM10 0 12131. 2 L 3.04 1 1.01E- 02 60.1 LYM17 11681. 4 o 1.38 5 1.88E- 01 9.1 LYM13 8 12561. 1 L 3.06 2 1.03E- 02 61.2 LYM15 11612. 2 o 1.48 3 2.29E- 01 16.8 LYM43 11791. 5 L 2.89 8 1.80E- 02 52.6 LYM14 3 12521. 1 o 1.40 7 2.32E- 01 10.8 LYM13 4 12314. 2 L 2.86 6 2.55E- 02 50.9 LYM19 11754. 1 o 1.46 4 2.44E- 01 15.3 LYM13 8 12561. 3 L 2.84 5 3.12E- 02 49.8 LYM9 11633. 7 o 1.54 2.49E- 01 21.3 LYM53 11841. 1 L 2.77 8 4.04E- 02 46.2 LYM13 8 12562. 1 o 1.36 4 2.52E- 01 7.4 LYM26 8 12482. 3 L 2.77 7 4.10E- 02 46.2 LYM13 0 12332. 2 o 1.67 5 2.61E- 01 31.9 LYM29 0 12502. 4 L 2.75 6 5.17E- 02 45.1 LYM11 9 12462. 1 o 1.81 2 2.70E- 01 42.7 LYM14 3 12524. 2 L 2.7 5.53E- 02 42.2 LYM14 3 12524. 2 o 1.48 2 2.87E- 01 16.7 LYM51 11893. 4 L 2.78 2 6.14E- 02 46.4 LYM17 4 12414. 3 o 1.87 1 3.05E- 01 47.3 LYM13 7 12151. 1 L 2.69 8 6.26E- 02 42 LYM13 8 12561. 3 o 1.81 6 3.10E- 01 43 LYM31 11923. 4 L 2.66 5 6.28E- 02 40.3 2016213786 11 Aug 2016 333 Gene name Event I D Mea n P value % incr. vs. cont. Gene name Event I D Mea n P value % incr. vs. cont. LYM11 3 12442. 1 O 1.35 5 3.16E- 01 6.7 LYM14 3 12524. 7 L 2.88 3 6.35E- 02 51.8 LYM21 11673. 1 o 1.47 1 3.28E- 01 15.9 LYM68 11942. 3 L 2.65 9 7.46E- 02 40 LYM15 11612. 3 o 1.63 8 3.31E- 01 29 LYM11 9 12461. 1 L 2.85 1 7.88E- 02 50.1 LYM13 4 12311. 2 o 1.58 5 3.39E- 01 24.8 LYM68 11941. 3 L 2.63 1 7.90E- 02 38.5 LYM14 1 12404. 3 o 1.53 2 3.45E- 01 20.7 LYM14 8 12171. 2 L 2.59 5 9.52E- 02 36.6 LYM19 11751. 4 o 1.65 6 3.52E- 01 30.4 LYM57 12013. 5 L 2.59 2 9.88E- 02 36.4 LYM2 11692. 3 o 1.35 8 3.74E- 01 7 LYM11 1 12254. 3 L 2.67 7 1.14E- 01 40.9 LYM12 9 12573. 5 o 1.34 3 3.76E- 01 5.7 LYM69 11853. 5 L 2.54 5 1.23E- 01 34 LYM4 11705. 2 o 1.52 3 3.80E- 01 19.9 LYM30 11912. 6 L 2.52 7 1.45E- 01 33 LYM16 2 12231. 1 o 1.58 4 3.81E- 01 24.7 LYM14 0 12264. 1 L 2.49 5 1.50E- 01 31.3 LYM15 2 12371. 2 o 1.53 8 4.01E- 01 21.1 LYM15 2 12372. 1 L 2.55 8 1.54E- 01 34.6 LYM15 11611. 3 o 1.69 4 4.12E- 01 33.4 LYM68 11943. 2 L 2.48 8 1.58E- 01 31 LYM21 11671. 2 o 1.50 5 4.27E- 01 18.5 LYM43 11791. 4 L 2.45 4 1.80E- 01 29.2 LYM28 9 12491. 1 o 1.67 4.28E- 01 31.5 LYM62 12021. 1 L 2.44 9 1.93E- 01 28.9 LYM28 9 12491. 4 o 1.42 3 4.32E- 01 12.1 LYM53 11844. 2 L 2.46 1 1.95E- 01 29.6 LYM14 1 12404. 4 o 1.56 4.38E- 01 22.9 LYM30 11913. 5 L 2.44 3 1.99E- 01 28.6 LYM16 2 12234. 4 o 1.76 8 4.46E- 01 39.2 LYM13 7 12154. 5 L 2.43 8 2.03E- 01 28.4 LYM14 8 12173. 1 o 1.60 5 4.55E- 01 26.4 LYM17 0 12453. 2 L 2.39 6 2.19E- 01 26.2 LYM29 0 12501. 3 o 1.43 3 4.56E- 01 12.8 LYM11 9 12462. 2 L 2.39 2.40E- 01 25.8 LYM10 2 12222. 3 o 1.60 5 5.03E- 01 26.4 LYM11 1 12254. 4 L 2.39 9 2.43E- 01 26.3 LYM17 4 12411. 3 o 1.49 1 5.04E- 01 17.4 LYM17 2 12301. 2 L 2.36 5 2.52E- 01 24.5 LYM17 4 12412. 1 o 1.55 4 5.23E- 01 22.4 LYM11 1 12251. 3 L 2.35 9 2.67E- 01 24.2 LYM26 8 12483. 4 o 1.43 4 5.36E- 01 13 LYM51 11893. 2 L 2.33 2 2.92E- 01 22.8 LYM11 1 12251. 1 o 1.49 8 5.37E- 01 18 LYM29 0 12502. 2 L 2.35 7 2.97E- 01 24.1 LYM21 11672. 4 o 1.46 6 5.47E- 01 15.4 LYM10 5 12294. 3 L 2.30 5 3.15E- 01 21.3 LYM29 0 12502. 4 o 1.46 9 5.82E- 01 15.7 LYM13 0 12332. 2 L 2.29 4 3.24E- 01 20.8 2016213786 11 Aug 2016 334 Gene name Event I D Mea n P value % incr. vs. cont. Gene name Event I D Mea n P value % incr. vs. cont. LYM10 11744. 5 O 1.44 1 5.83E- 01 13.5 LYM68 11942. 2 L 2.29 8 3.35E- 01 21 LYM13 11772. 1 o 1.35 2 5.92E- 01 6.5 LYM26 8 12481. 1 L 2.27 5 3.51E- 01 19.7 LYM17 11684. 5 o 1.31 4 6.05E- 01 3.5 LYM10 5 12295. 2 L 2.27 7 3.56E- 01 19.9 LYM17 11682. 1 o 1.53 6 6.12E- 01 20.9 LYM13 0 12331. 3 L 2.24 1 3.81E- 01 18 LYM26 8 12482. 3 o 1.34 8 6.33E- 01 6.2 LYM14 8 12173. 1 L 2.24 7 3.93E- 01 18.3 LYM16 11624. 4 o 1.30 9 6.51E- 01 3.1 LYM15 2 12376. 1 L 2.24 6 3.97E- 01 18.2 LYM10 5 12294. 2 o 1.53 6 6.73E- 01 21 LYM29 0 12501. 3 L 2.23 5 4.07E- 01 17.7 LYM17 11683. 1 o 1.30 6 6.85E- 01 2.9 LYM57 12012. 2 L 2.22 5 4.17E- 01 17.1 LYM13 7 12153. 1 o 1.36 7 7.39E- 01 7.7 LYM13 2 12276. 1 L 2.21 6 4.40E- 01 16.6 LYM11 1 12252. 2 o 1.43 7 7.64E- 01 13.1 LYM14 12052. 4 L 2.20 1 4.53E- 01 15.9 LYM10 11742. 1 o 1.41 8 7.68E- 01 11.7 LYM13 7 12152. 1 L 2.20 4 4.55E- 01 16 LYM10 0 12131. 3 o 1.35 1 8.06E- 01 6.4 LYM62 12022. 1 L 2.19 5 4.65E- 01 15.5 LYM17 4 12414. 2 o 1.28 4 8.53E- 01 1.1 LYM10 0 12134. 1 L 2.18 7 4.81E- 01 15.1 LYM9 11633. 2 o 1.32 8.63E- 01 4 LYM26 11824. 6 L 2.17 7 4.90E- 01 14.6 LYM16 2 12233. 2 o 1.31 5 8.71E- 01 3.6 LYM57 12012. 6 L 2.16 9 5.11E- 01 14.2 LYM14 8 12172. 1 o 1.34 9 8.73E- 01 6.3 LYM53 11842. 4 L 2.17 9 5.18E- 01 14.7 LYM26 8 12482. 1 o 1.31 9.06E- 01 3.2 LYM67 11783. 5 L 2.16 2 5.19E- 01 13.8 LYM14 0 12261. 4 o 1.28 7 9.25E- 01 1.3 LYM13 2 12271. 4 L 2.15 7 5.24E- 01 13.5 LYM29 0 12502. 1 o 1.30 1 9.27E- 01 2.5 LYM10 0 12131. 3 L 2.14 1 5.42E- 01 12.7 LYM1 11601. 1 o 1.28 9.68E- 01 0.8 LYM15 2 12372. 2 L 2.13 2 5.59E- 01 12.2 LYM22 11762. 1 o 1.27 9.99E- 01 0 LYM13 8 12562. 1 L 2.12 4 5.80E- 01 11.8 CONTR OL _ o 1.27 _ 0 LYM43 11792. 2 L 2.11 9 6.05E- 01 11.6 LYM14 3 12524. 7 P 2.58 1 6.00E- 06 38 LYM51 11894. 2 L 2.09 7 6.19E- 01 10.4 LYM14 8 12171. 2 P 2.42 2 1.00E- 04 29.5 LYM13 0 12334. 1 L 2.08 2 6.35E- 01 9.6 LYM14 8 12174. 1 P 2.32 4 1.00E- 04 24.2 LYM43 11793. 2 L 2.09 2 6.44E- 01 10.1 LYM4 11706. 5 P 2.30 2 1.40E- 04 23.1 LYM13 4 12312. 4 L 2.08 2 6.55E- 01 9.6 2016213786 11 Aug 2016 335 Gene name Event I D Mea n P value % incr. vs. cont. Gene name Event I D Mea n P value % incr. vs. cont. LYM10 11744. 1 P 2.29 7 1.80E- 04 22.8 LYM14 12051. 4 L 2.07 7 6.58E- 01 9.4 LYM10 5 12293. 1 P 2.29 9 2.18E- 04 22.9 LYM11 9 12461. 4 L 2.07 2 6.66E- 01 9.1 LYM10 11742. 2 P 2.36 4 3.58E- 04 26.4 LYM13 2 12275. 1 L 2.06 5 6.78E- 01 8.7 LYM10 2 12222. 2 P 2.24 3 6.39E- 04 19.9 LYM30 11912. 7 L 2.05 7 6.96E- 01 8.3 LYM13 2 12273. 2 P 2.21 5 6.83E- 04 18.4 LYM16 2 12231. 3 L 2.05 6 7.00E- 01 8.2 LYM13 2 12271. 4 P 2.21 7.22E- 04 18.2 LYM13 7 12153. 1 L 2.05 4 7.02E- 01 8.1 LYM13 0 12333. 1 P 2.37 4 9.53E- 04 26.9 LYM25 4 12474. 4 L 2.06 6 7.04E- 01 00 00* LYM14 0 12262. 3 P 2.18 6 1.21E- 03 16.9 LYM14 3 12521. 2 L 2.04 9 7.08E- 01 7.8 LYM1 11602. 1 P 2.25 3 3.80E- 03 20.4 LYM10 0 12133. 3 L 2.03 5 7.35E- 01 7.1 LYM16 2 12234. 3 P 2.29 2 6.47E- 03 22.6 LYM30 11913. 3 L 2.02 7 7.48E- 01 6.7 LYM13 0 12334. 1 P 2.19 3 9.35E- 03 17.3 LYM68 11941. 4 L 2.01 3 7.74E- 01 6 LYM19 11751. 5 P 2.25 4 9.64E- 03 20.5 LYM15 2 12371. 2 L 2.01 2 7.89E- 01 5.9 LYM13 11771. 6 P 2.07 8 1.1 OE-02 11.1 LYM67 11782. 4 L 1.99 1 8.22E- 01 4.8 LYM28 9 12493. 2 P 2.34 7 1.26E- 02 25.5 LYM26 11824. 5 L 1.97 3 8.52E- 01 3.9 LYM11 9 12463. 2 P 2.16 6 1.42E- 02 15.8 LYM13 8 12564. 1 L 1.97 6 8.53E- 01 4 LYM10 11741. 2 P 2.72 9 1.57E- 02 45.9 LYM51 11891. 1 L 1.97 2 8.55E- 01 3.8 LYM10 2 12221. 1 P 2.05 8 1.68E- 02 10.1 LYM15 2 12373. 1 L 1.97 6 8.56E- 01 4 LYM15 2 12372. 2 P 2.24 3 2.00E- 02 20 LYM95 12124. 4 L 1.96 2 8.74E- 01 3.3 LYM17 11684. 4 P 2.11 1 2.86E- 02 12.9 LYM26 8 12483. 2 L 1.96 2 8.79E- 01 3.3 LYM1 11602. 6 P 2.69 1 3.00E- 02 43.9 LYM31 11922. 3 L 1.95 9 8.80E- 01 3.1 LYM14 1 12404. 2 P 2.03 3.41E- 02 8.5 LYM17 2 12302. 2 L 1.94 8 9.08E- 01 2.6 LYM15 11612. 2 P 2.08 3 3.48E- 02 11.4 LYM14 12051. 1 L 1.94 4 9.11E- 01 2.4 LYM14 3 12524. 2 P 2.02 6 3.61E- 02 8.3 LYM69 11852. 4 L 1.93 9 9.21E- 01 2.1 LYM13 11772. 1 P 2.06 1 3.72E- 02 10.2 LYM11 1 12251. 1 L 1.93 6 9.27E- 01 1.9 LYM14 3 12521. 1 P 2.05 4 4.46E- 02 9.8 LYM66 11954. 4 L 1.92 2 9.59E- 01 1.2 LYM10 0 12133. 1 P 2.12 4.61E- 02 13.4 LYM10 5 12297. 1 L 1.91 2 9.76E- 01 0.6 2016213786 11 Aug 2016 336 Gene name Event I D Mea n P value % incr. vs. cont. Gene name Event I D Mea n P value % incr. vs. cont. LYM16 11624. 4 P 2.01 4 4.89E- 02 7.7 LYM14 0 12262. 3 L 1.90 6 9.87E- 01 0.3 LYM17 11681. 4 P 2.01 9 5.10E- 02 8 LYM29 0 12502. 1 L 1.90 6 9.88E- 01 0.3 LYM19 11753. 1 P 2.14 9 5.24E- 02 14.9 CONTR OL _ L 1.9 _ 0 LYM13 8 12562. 1 P 2.00 8 6.33E- 02 7.3 LYM11 1 12252. 2 M 0.53 7 2.20E- 05 121 LYM1 11603. 2 P 2.09 6 8.89E- 02 12.1 LYM14 8 12174. 1 M 0.44 7 3.03E- 04 84 LYM9 11632. 1 P 2.65 5 9.51E- 02 42 LYM11 9 12462. 1 M 0.39 1 5.76E- 03 60.6 LYM11 9 12461. 4 P 2.17 2 9.96E- 02 16.1 LYM10 0 12131. 2 M 0.38 7.86E- 03 56.3 LYM12 9 12573. 5 P 1.98 9 1.00E- 01 6.3 LYM13 8 12561. 1 M 0.38 3 8.16E- 03 57.4 LYM19 11754. 1 P 2.12 5 1.17E- 01 13.6 LYM43 11791. 5 M 0.36 2 1.43E- 02 49 LYM17 4 12411. 2 P 2.28 7 1.23E- 01 22.3 LYM13 4 12314. 2 M 0.35 8 2.14E- 02 47.3 LYM11 3 12442. 1 P 2.05 4 1.24E- 01 9.8 LYM13 8 12561. 3 M 0.35 6 2.71E- 02 46.2 LYM14 1 12402. 4 P 2.33 1.29E- 01 24.6 LYM11 9 12461. 1 M 0.37 3 3.52E- 02 53.4 LYM15 11614. 3 P 2.23 2 1.30E- 01 19.4 LYM53 11841. 1 M 0.34 7 3.56E- 02 42.8 LYM28 9 12493. 6 P 2.05 1 1.31E- 01 9.7 LYM26 8 12482. 3 M 0.34 7 3.61E- 02 42.7 LYM9 11632. 2 P 2.11 3 1.36E- 01 13 LYM29 0 12502. 4 M 0.34 4 4.73E- 02 41.6 LYM13 8 12561. 1 P 2.47 1.39E- 01 32 LYM14 3 12524. 2 M 0.33 8 4.96E- 02 38.8 LYM11 9 12462. 2 P 2.51 9 1.48E- 01 34.7 LYM31 11923. 4 M 0.33 3 5.67E- 02 37 LYM9 11633. 7 P 2.10 2 1.55E- 01 12.4 LYM13 7 12151. 1 M 0.33 7 5.76E- 02 38.7 LYM16 2 12231. 1 P 2.16 3 1.88E- 01 15.6 LYM51 11893. 4 M 0.34 8 5.87E- 02 43 LYM16 2 12231. 3 P 2.12 8 1.99E- 01 13.8 LYM14 3 12524. 7 M 0.36 6.28E- 02 48.2 LYM4 11705. 2 P 2.12 7 2.10E- 01 13.8 LYM68 11942. 3 M 0.33 2 6.98E- 02 36.7 LYM14 1 12404. 3 P 2.09 8 2.18E- 01 12.2 LYM68 11941. 3 M 0.32 9 7.35E- 02 35.2 LYM17 4 12414. 3 P 2.42 4 2.25E- 01 29.6 LYM14 8 12171. 2 M 0.32 4 9.03E- 02 33.4 LYM1 11604. 4 P 2.31 6 2.37E- 01 23.8 LYM57 12013. 5 M 0.32 4 9.44E- 02 33.2 LYM19 11751. 4 P 2.19 9 2.40E- 01 17.6 LYM17 0 12453. 2 M 0.32 1 9.97E- 02 31.9 LYM28 9 12491. 4 P 2.03 3 2.41E- 01 8.7 LYM11 1 12254. 3 M 0.33 5 1.15E- 01 37.6 2016213786 11 Aug 2016 337 Gene name Event I D Mea n P value % incr. vs. cont. Gene name Event I D Mea n P value % incr. vs. cont. LYM13 8 12561. 3 P 2.30 6 2.48E- 01 23.3 LYM69 11853. 5 M 0.31 8 1.20E- 01 30.8 LYM13 4 12311. 2 P 2.17 8 2.62E- 01 16.5 LYM30 11912. 6 M 0.31 6 1.45E- 01 29.9 LYM13 0 12332. 2 P 2.28 2.65E- 01 21.9 LYM14 0 12264. 1 M 0.31 2 1.48E- 01 28.2 LYM21 11673. 1 P 2.11 4 2.76E- 01 13 LYM15 2 12372. 1 M 0.32 1.56E- 01 31.5 LYM15 2 12371. 2 P 2.12 7 2.84E- 01 13.7 LYM68 11943. 2 M 0.31 1 1.58E- 01 27.9 LYM11 9 12462. 1 P 2.28 1 3.03E- 01 21.9 LYM43 11791. 4 M 0.30 7 1.81E- 01 26.1 LYM26 8 12483. 2 P 2.12 1 3.07E- 01 13.4 LYM62 12021. 1 M 0.30 6 1.96E- 01 25.9 LYM17 4 12414. 2 P 2.01 6 3.46E- 01 7.8 LYM53 11844. 2 M 0.30 8 1.99E- 01 26.5 LYM17 4 12411. 3 P 2.15 1 3.50E- 01 15 LYM30 11913. 5 M 0.30 5 2.03E- 01 25.6 LYM15 11612. 3 P 2.18 7 3.58E- 01 16.9 LYM13 7 12154. 5 M 0.30 5 2.08E- 01 25.3 LYM17 4 12412. 1 P 2.15 5 3.66E- 01 15.2 LYM11 9 12462. 2 M 0.29 9 2.48E- 01 22.9 LYM14 8 12173. 1 P 2.15 3 3.73E- 01 15.1 LYM11 1 12254. 4 M 0.3 2.52E- 01 23.3 LYM14 1 12404. 4 P 2.15 8 3.80E- 01 15.4 LYM17 2 12301. 2 M 0.29 6 2.60E- 01 21.6 LYM29 0 12501. 3 P 2.12 5 3.82E- 01 13.6 LYM13 2 12276. 1 M 0.29 5 2.66E- 01 21.5 LYM16 2 12234. 4 P 2.29 6 4.09E- 01 22.8 LYM11 1 12251. 3 M 0.29 5 2.78E- 01 21.2 LYM11 1 12251. 1 P 2.09 8 4.17E- 01 12.2 LYM51 11893. 2 M 0.29 1 3.06E- 01 19.9 LYM15 11611. 3 P 2.21 4 4.19E- 01 18.4 LYM29 0 12502. 2 M 0.29 5 3.12E- 01 21.2 LYM22 11762. 1 P 1.92 1 4.32E- 01 2.7 LYM67 11783. 5 M 0.29 2 3.23E- 01 20 LYM13 2 12275. 1 P 1.95 7 4.42E- 01 4.7 LYM10 5 12294. 3 M 0.28 8 3.31E- 01 18.5 LYM21 11671. 2 P 2.07 9 4.44E- 01 11.1 LYM13 0 12332. 2 M 0.28 7 3.41E- 01 17.9 LYM17 11684. 5 P 1.91 8 4.53E- 01 2.6 LYM68 11942. 2 M 0.28 7 3.54E- 01 18.1 LYM2 11692. 3 P 1.91 8 4.54E- 01 2.6 LYM26 8 12481. 1 M 0.28 4 3.71E- 01 16.9 LYM13 7 12153. 1 P 2.03 3 4.60E- 01 8.7 LYM10 5 12295. 2 M 0.28 5 3.77E- 01 17 LYM10 2 12222. 3 P 2.20 6 4.62E- 01 18 LYM13 0 12331. 3 M 0.28 4.04E- 01 15.2 LYM17 11683. 1 P 1.93 6 4.85E- 01 3.5 LYM14 8 12173. 1 M 0.28 1 4.20E- 01 15.5 LYM28 9 12491. 1 P 2.16 8 5.00E- 01 15.9 LYM15 2 12376. 1 M 0.28 1 4.24E- 01 15.4 2016213786 11 Aug 2016 338 Gene name Event I D Mea n P value % incr. vs. cont. Gene name Event I D Mea n P value % incr. vs. cont. LYM10 11744. 5 P 2.06 5.04E- 01 10.1 LYM29 0 12501. 3 M 0.27 9 4.35E- 01 14.9 LYM1 11601. 1 P 2.07 5 5.18E- 01 10.9 LYM57 12012. 2 M 0.27 8 4.46E- 01 14.4 LYM26 8 12483. 4 P 2.04 9 5.28E- 01 9.5 LYM14 12052. 4 M 0.27 5 4.87E- 01 13.1 LYM17 11682. 1 P 2.15 4 5.33E- 01 15.2 LYM13 7 12152. 1 M 0.27 6 4.89E- 01 13.3 LYM21 11672. 4 P 2.07 1 5.40E- 01 10.7 LYM62 12022. 1 M 0.27 4 5.01E- 01 12.8 LYM11 1 12254. 4 P 1.92 9 5.68E- 01 3.2 LYM13 7 12153. 1 M 0.27 5 5.04E- 01 13.1 LYM13 11771. 9 P 1.97 4 5.76E- 01 5.5 LYM10 0 12134. 1 M 0.27 3 5.19E- 01 12.4 LYM26 8 12482. 3 P 1.97 4 5.94E- 01 5.5 LYM26 11824. 6 M 0.27 2 5.29E- 01 11.9 LYM2 11693. 3 P 1.92 9 5.99E- 01 3.1 LYM57 12012. 6 M 0.27 1 5.53E- 01 11.5 LYM29 0 12502. 4 P 2.02 5 6.17E- 01 8.3 LYM53 11842. 4 M 0.27 2 5.60E- 01 12 LYM14 0 12261. 4 P 1.94 7 6.59E- 01 4.1 LYM13 2 12271. 4 M 0.27 5.68E- 01 10.8 LYM26 8 12482. 1 P 1.96 9 6.73E- 01 5.3 LYM68 11941. 4 M 0.26 9 5.74E- 01 10.5 LYM14 8 12172. 1 P 2.06 9 6.76E- 01 10.6 LYM10 0 12131. 3 M 0.26 8 5.89E- 01 10.1 LYM10 11742. 1 P 1.99 9 6.93E- 01 6.9 LYM15 2 12372. 2 M 0.26 6 6.09E- 01 9.6 LYM19 11752. 2 P 1.95 4 6.98E- 01 4.5 LYM13 8 12562. 1 M 0.26 6 6.32E- 01 9.2 LYM14 3 12521. 2 P 1.91 1 7.08E- 01 2.2 LYM43 11792. 2 M 0.26 5 6.58E- 01 8.9 LYM10 5 12294. 2 P 2.02 5 7.30E- 01 8.3 LYM51 11894. 2 M 0.26 2 6.76E- 01 7.8 LYM11 1 12252. 2 P 2 7.59E- 01 6.9 LYM13 0 12334. 1 M 0.26 6.96E- 01 7 LYM10 0 12131. 3 P 1.94 7.90E- 01 3.7 LYM43 11793. 2 M 0.26 2 7.03E- 01 7.5 LYM15 3 12323. 2 P 1.89 3 7.92E- 01 1.2 LYM13 4 12312. 4 M 0.26 7.16E- 01 7 LYM16 2 12233. 2 P 1.92 7 7.99E- 01 3 LYM14 12051. 4 M 0.26 7.20E- 01 6.8 LYM14 3 12523. 4 P 1.91 8.45E- 01 2.1 LYM11 9 12461. 4 M 0.25 9 7.29E- 01 6.5 LYM2 11695. 3 P 1.88 5 8.49E- 01 0.8 LYM13 2 12275. 1 M 0.25 8 7.43E- 01 6.1 LYM15 3 12321. 2 P 1.91 5 8.77E- 01 2.4 LYM30 11912. 7 M 0.25 7 7.63E- 01 5.7 LYM9 11633. 2 P 1.91 3 8.81E- 01 2.3 LYM25 4 12474. 4 M 0.25 8 7.67E- 01 6.2 LYM13 0 12331. 3 P 1.88 6 9.18E- 01 0.9 LYM16 2 12231. 3 M 0.25 7 7.67E- 01 5.7 2016213786 11 Aug 2016 339 Gene name Event I D Mea n P value % incr. vs. cont. Gene name Event I D Mea n P value % incr. vs. cont. LYM13 2 12275. 3 P 1.90 8 9.31E- 01 2 LYM14 3 12521. 2 M 0.25 6 7.77E- 01 5.3 LYM10 2 12222. 6 P 1.88 2 9.74E- 01 0.6 LYM26 8 12482. 1 M 0.25 7 7.87E- 01 5.7 LYM29 0 12502. 1 P 1.87 1 9.99E- 01 0 LYM10 0 12133. 3 M 0.25 4 8.07E- 01 4.6 CONTR OL _ P 1.87 _ 0 LYM69 11854. 2 M 0.25 4 8.16E- 01 4.4 LYM10 3 12713. 5 A 95.4 46 6.40E- 05 3.7 LYM15 3 12321. 2 M 0.25 4 8.20E- 01 4.4 LYM20 11711. 2 A 94.1 99 1.22E- 03 2.3 LYM30 11913. 3 M 0.25 3 8.23E- 01 4.2 LYM51 11891. 1 A 93.9 81 1.89E- 03 2.1 LYM15 2 12371. 2 M 0.25 2 8.64E- 01 3.4 LYM11 0 12921. 7 A 94.0 61 1.99E- 03 2.2 LYM67 11782. 4 M 0.24 9 9.03E- 01 2.3 LYM30 11913. 3 A 93.9 36 2.18E- 03 2.1 LYM13 8 12564. 1 M 0.24 7 9.36E- 01 1.6 LYM31 11924. 4 A 93.8 65 2.88E- 03 2 LYM15 2 12373. 1 M 0.24 7 9.38E- 01 1.6 LYM56 13111. 5 A 93.8 43 2.90E- 03 2 LYM26 11824. 5 M 0.24 7 9.39E- 01 1.4 LYM82 12204. 2 A 93.8 24 3.63E- 03 1.9 LYM51 11891. 1 M 0.24 6 9.42E- 01 1.3 LYM95 12121. 2 A 94.2 94 3.66E- 03 2.4 LYM95 12124. 4 M 0.24 5 9.64E- 01 0.8 LYM30 11913. 4 A 94.5 32 5.55E- 03 2.7 LYM26 8 12483. 2 M 0.24 5 9.65E- 01 0.9 LYM14 5 12951. 9 A 93.6 12 6.11E- 03 1.7 LYM31 11922. 3 M 0.24 5 9.70E- 01 0.7 LYM95 12124. 6 A 93.5 99 6.49E- 03 1.7 LYM17 2 12302. 2 M 0.24 4 9.95E- 01 0.1 LYM12 8 12641. 3 A 93.5 73 6.95E- 03 1.7 CONTR OL _ M 0.24 3 _ 0 LYM41 11834. 2 A 93.7 77 7.60E- 03 1.9 LYM11 1 12252. 2 N 0.36 5 8.67E- 04 57.1 LYM43 11791. 5 A 94.1 66 8.49E- 03 2.3 LYM14 8 12174. 1 N 0.31 2 1.65E- 02 34.3 LYM66 11954. 4 A 93.6 58 1.06E- 02 1.7 LYM69 11853. 5 N 0.29 5 5.60E- 02 27 LYM14 12051. 4 A 93.4 06 1.22E- 02 1.5 LYM13 8 12561. 1 N 0.29 6 6.19E- 02 27.2 LYM11 6 13202. 12 A 93.7 53 1.48E- 02 1.9 LYM11 9 12462. 1 N 0.29 8.42E- 02 24.7 LYM27 1 12721. 9 A 93.4 59 1.61E- 02 1.5 LYM10 0 12131. 2 N 0.28 8 8.55E- 02 23.7 LYM14 5 12954. 8 A 93.3 11 1.71E- 02 1.4 LYM14 3 12524. 2 N 0.28 6 9.40E- 02 22.8 LYM41 11832. 2 A 93.2 79 1.90E- 02 1.3 LYM68 11941. 3 N 0.28 1 1.21E- 01 21 LYM26 11821. 2 A 93.2 94 2.17E- 02 1.4 LYM11 9 12461. 1 N 0.29 5 1.24E- 01 26.9 2016213786 11 Aug 2016 340 Gene name Event I D Mea n P value % incr. vs. cont. Gene name Event I D Mea n P value % incr. vs. cont. LYM53 11841. 1 A 93.6 75 2.30E- 02 1.8 LYM67 11783. 5 N 0.28 3 1.38E- 01 21.6 LYM27 1 12724. 7 A 93.5 39 2.83E- 02 1.6 LYM13 4 12314. 2 N 0.27 7 1.56E- 01 18.9 LYM23 2 13024. 7 A 93.3 05 2.83E- 02 1.4 LYM13 8 12561. 3 N 0.27 8 1.57E- 01 19.4 LYM27 1 12723. 2 A 93.1 62 3.14E- 02 1.2 LYM31 11923. 4 N 0.27 7 1.57E- 01 19 LYM67 11782. 6 A 94.3 35 3.97E- 02 2.5 LYM29 0 12502. 4 N 0.27 7 1.64E- 01 19 LYM11 0 12923. 8 A 94.0 14 4.09E- 02 2.1 LYM57 12013. 5 N 0.27 6 1.67E- 01 18.7 LYM15 6 12961. 7 A 93.7 81 4.22E- 02 1.9 LYM26 8 12482. 3 N 0.27 6 1.68E- 01 18.8 LYM88 12191. 1 A 93.4 38 4.39E- 02 1.5 LYM53 11841. 1 N 0.27 6 1.75E- 01 18.7 LYM23 2 13024. 6 A 93.0 9 4.49E- 02 1.1 LYM62 12021. 1 N 0.27 5 2.00E- 01 18.4 LYM23 9 13044. 8 A 93.0 69 4.51E- 02 1.1 LYM14 3 12524. 7 N 0.28 2.15E- 01 20.4 LYM23 9 13042. 9 A 94.2 42 5.48E- 02 2.4 LYM30 11913. 5 N 0.27 3 2.18E- 01 17.4 LYM10 3 12712. 8 A 93.6 97 7.12E- 02 1.8 LYM53 11844. 2 N 0.27 2 2.53E- 01 16.7 LYM67 11782. 5 A 93.3 1 7.48E- 02 1.4 LYM51 11893. 4 N 0.27 2 2.62E- 01 16.8 LYM26 11824. 5 A 93.2 3 9.64E- 02 1.3 LYM30 11912. 6 N 0.26 8 2.72E- 01 15.1 LYM24 12064. 1 A 92.9 77 1.09E- 01 1 LYM68 11942. 3 N 0.26 7 2.76E- 01 15 LYM24 12061. 4 A 93.5 87 1.1 OE-01 1.7 LYM17 0 12453. 2 N 0.26 4 3.05E- 01 13.5 LYM26 11824. 6 A 93.6 26 1.16E- 01 1.7 LYM68 11943. 2 N 0.26 5 3.08E- 01 14 LYM28 5 12733. 9 A 93.4 76 1.19E- 01 1.6 LYM11 1 12254. 3 N 0.27 1 3.36E- 01 16.4 LYM99 12243. 2 A 93.2 27 1.26E- 01 1.3 LYM13 7 12151. 1 N 0.26 1 3.59E- 01 12.4 LYM66 11952. 2 A 92.7 47 1.33E- 01 0.8 LYM14 0 12264. 1 N 0.26 3.88E- 01 11.6 LYM82 12201. 5 A 93.0 06 1.35E- 01 1 LYM15 2 12372. 1 N 0.26 4 3.92E- 01 13.5 LYM95 12124. 4 A 93.5 98 1.41E- 01 1.7 LYM43 11791. 5 N 0.25 8 4.06E- 01 11 LYM26 11824. 1 A 94.0 62 1.54E- 01 2.2 LYM13 7 12154. 5 N 0.25 8 4.09E- 01 11 LYM53 11844. 2 A 92.9 49 1.58E- 01 1 LYM29 0 12502. 2 N 0.25 8 4.41E- 01 10.8 LYM23 8 12762. 8 A 92.6 61 1.75E- 01 0.7 LYM11 1 12251. 3 N 0.25 7 4.46E- 01 10.7 LYM57 12013. 3 A 93.0 63 1.82E- 01 1.1 LYM10 5 12295. 2 N 0.25 6 4.60E- 01 10.1 2016213786 11 Aug 2016 341 Gene name Event I D Mea n P value % incr. vs. cont. Gene name Event I D Mea n P value % incr. vs. cont. LYM12 5 12934. 5 A 94.0 64 1.92E- 01 2.2 LYM11 1 12254. 4 N 0.25 5 4.96E- 01 9.7 LYM12 8 12641. 5 A 93.6 44 1.94E- 01 1.7 LYM26 8 12481. 1 N 0.25 3 5.27E- 01 8.6 LYM51 11894. 2 A 92.9 55 1.98E- 01 1 LYM51 11893. 2 N 0.25 1 5.42E- 01 8 LYM66 11955. 2 A 93.6 58 2.03E- 01 1.7 LYM51 11891. 1 N 0.25 1 5.54E- 01 7.9 LYM23 8 12763. 5 A 93.4 75 2.13E- 01 1.6 LYM68 11942. 2 N 0.25 1 5.61E- 01 8.1 LYM20 11712. 2 A 92.9 72 2.19E- 01 1 LYM17 2 12301. 2 N 0.25 5.79E- 01 7.6 LYM14 5 12953. 5 A 93.9 25 2.34E- 01 2 LYM13 7 12153. 1 N 0.24 9 5.93E- 01 7.3 LYM53 11843. 2 A 92.9 2.43E- 01 0.9 LYM13 8 12562. 1 N 0.24 9 6.03E- 01 6.9 LYM12 5 12932. 8 A 97.2 38 2.56E- 01 5.6 LYM43 11791. 4 N 0.24 9 6.08E- 01 6.9 LYM28 4 12883. 5 A 95.3 09 2.58E- 01 3.5 LYM10 5 12294. 3 N 0.24 8 6.13E- 01 6.7 LYM41 11831. 5 A 93.3 47 2.68E- 01 1.4 LYM14 8 12171. 2 N 0.24 8 6.13E- 01 6.7 LYM28 4 12884. 7 A 93.4 92 2.80E- 01 1.6 LYM10 0 12131. 3 N 0.24 8 6.13E- 01 6.6 LYM12 5 12934. 7 A 92.5 35 2.81E- 01 0.5 LYM62 12022. 1 N 0.24 7 6.26E- 01 6.4 LYM26 11824. 3 A 94.2 93 2.82E- 01 2.4 LYM13 2 12276. 1 N 0.24 9 6.26E- 01 6.9 LYM27 7 13104. 9 A 94.2 32 3.03E- 01 2.4 LYM13 0 12331. 3 N 0.24 7 6.36E- 01 6.1 LYM15 6 12963. 4 A 93.3 22 3.23E- 01 1.4 LYM26 11824. 6 N 0.24 8 6.42E- 01 6.5 LYM27 7 13101. 1 A 93.4 57 3.32E- 01 1.5 LYM14 12052. 4 N 0.24 5 6.80E- 01 5.5 LYM27 7 13105. 7 A 93.1 65 3.34E- 01 1.2 LYM15 2 12376. 1 N 0.24 6 6.82E- 01 5.6 LYM88 12194. 2 A 92.7 73 3.50E- 01 0.8 LYM43 11792. 2 N 0.24 6 6.97E- 01 5.7 LYM30 11912. 7 A 93.3 71 3.68E- 01 1.4 LYM10 0 12134. 1 N 0.24 5 7.03E- 01 5.3 LYM10 3 12712. 5 A 94.0 13 3.80E- 01 2.1 LYM57 12012. 2 N 0.24 4 7.15E- 01 4.8 LYM11 6 13204. 4 A 92.4 11 4.06E- 01 0.4 LYM10 5 12297. 1 N 0.24 3 7.31E- 01 4.7 LYM99 12244. 1 A 92.8 73 4.11E- 01 0.9 LYM13 7 12152. 1 N 0.24 2 7.68E- 01 3.9 LYM57 12013. 5 A 92.8 67 4.13E- 01 0.9 LYM15 2 12372. 2 N 0.24 2 7.69E- 01 3.9 LYM12 8 12641. 1 A 92.4 36 4.13E- 01 0.4 LYM10 0 12133. 3 N 0.24 1 7.86E- 01 3.6 LYM11 0 12924. 5 A 93.5 92 4.13E- 01 1.7 LYM11 9 12462. 2 N 0.24 1 7.88E- 01 3.7 2016213786 11 Aug 2016 342 Gene name Event I D Mea n P value % incr. vs. cont. Gene name Event I D Mea n P value % incr. vs. cont. LYM66 11953. 6 A 93.5 38 4.18E- 01 1.6 LYM24 12061. 2 N 0.24 1 7.97E- 01 3.6 LYM57 12012. 2 A 92.7 05 4.22E- 01 0.7 LYM14 3 12521. 2 N 0.24 8.16E- 01 3.1 LYM14 5 12952. 9 A 92.4 82 4.55E- 01 0.5 LYM14 8 12173. 1 N 0.24 8.22E- 01 3 LYM99 12241. 1 A 93.2 81 4.58E- 01 1.3 LYM69 11854. 2 N 0.23 9 8.47E- 01 2.5 LYM15 6 12961. 9 A 93.7 23 4.82E- 01 1.8 LYM14 12051. 4 N 0.23 7 8.82E- 01 2 LYM56 13112. 7 A 93.7 81 4.85E- 01 1.9 LYM13 2 12271. 4 N 0.23 7 8.82E- 01 2 LYM82 12201. 1 A 92.9 48 5.15E- 01 1 LYM29 0 12501. 3 N 0.23 7 8.83E- 01 2 LYM11 6 13202. 7 A 92.9 51 5.22E- 01 1 LYM26 8 12482. 1 N 0.23 8 8.83E- 01 2.3 LYM23 9 13041. 7 A 92.4 82 5.31E- 01 0.5 LYM15 2 12373. 1 N 0.23 7 9.00E- 01 1.9 LYM28 4 12884. 6 A 92.9 58 5.74E- 01 1 LYM25 4 12474. 4 N 0.23 7 9.03E- 01 1.9 LYM56 13112. 5 A 93.5 18 5.79E- 01 1.6 LYM68 11941. 4 N 0.23 6 9.24E- 01 1.3 LYM15 6 12963. 3 A 92.9 31 5.88E- 01 1 LYM13 0 12334. 1 N 0.23 5 9.24E- 01 1.2 LYM51 11893. 4 A 92.9 63 5.94E- 01 1 LYM11 1 12251. 1 N 0.23 5 9.41E- 01 1 LYM12 1 13211. 8 A 92.8 58 6.05E- 01 0.9 LYM14 12052. 5 N 0.23 5 9.44E- 01 0.9 LYM11 0 12923. 5 A 92.5 76 6.26E- 01 0.6 LYM66 11954. 4 N 0.23 5 9.46E- 01 1.1 LYM67 11782. 4 A 92.5 33 6.33E- 01 0.5 LYM14 0 12261. 1 N 0.23 4 9.57E- 01 0.8 LYM12 11871. 1 A 92.3 19 6.34E- 01 0.3 LYM15 2 12371. 2 N 0.23 4 9.76E- 01 0.4 LYM10 3 12713. 7 A 93.4 6 6.35E- 01 1.5 CONTR OL _ N 0.23 3 _ 0 LYM62 12022. 4 A 93.3 15 6.56E- 01 1.4 LYM13 4 12314. 2 O 2.87 7 1.57E- 04 44.9 LYM43 11793. 2 A 92.8 4 6.72E- 01 0.9 LYM26 8 12482. 3 O 2.82 7 2.54E- 04 42.3 LYM69 11852. 4 A 92.3 47 6.74E- 01 0.3 LYM13 8 12561. 1 o 3.13 2 7.56E- 04 57.7 LYM31 11923. 1 A 93.0 48 6.91E- 01 1.1 LYM43 11791. 5 o 2.97 8 3.01E- 03 49.9 LYM99 12244. 2 A 92.2 12 7.08E- 01 0.2 LYM10 0 12131. 2 o 3.09 7 5.61E- 03 55.9 LYM95 12121. 4 A 92.3 76 7.27E- 01 0.4 LYM17 0 12453. 2 o 2.58 9 6.69E- 03 30.3 LYM43 11792. 2 A 92.6 2 7.34E- 01 0.6 LYM14 0 12264. 1 o 2.55 7 7.02E- 03 28.7 LYM14 12052. 4 A 92.7 27 7.41E- 01 0.7 LYM57 12013. 5 o 2.67 2 1.45E- 02 34.6 2016213786 11 Aug 2016 343 Gene name Event I D Mea n P value % incr. vs. cont. Gene name Event I D Mea n P value % incr. vs. cont. LYM66 11953. 1 A 92.6 66 7.44E- 01 0.7 LYM68 11942. 3 O 2.73 7 1.48E- 02 37.8 LYM12 11872. 1 A 92.7 24 7.81E- 01 0.7 LYM14 3 12524. 2 o 2.75 5 1.94E- 02 38.7 LYM23 8 12764. 8 A 92.2 36 7.83E- 01 0.2 LYM14 8 12174. 1 o 3.67 2.35E- 02 84.8 LYM11 6 13201. 8 A 92.4 84 7.84E- 01 0.5 LYM31 11923. 4 o 2.75 1 2.44E- 02 38.5 LYM82 12203. 3 A 92.1 75 8.22E- 01 0.1 LYM13 0 12331. 3 o 2.36 3 2.49E- 02 19 LYM23 8 12761. 6 A 92.2 22 8.23E- 01 0.2 LYM69 11853. 5 o 2.57 2 4.76E- 02 29.5 LYM67 11781. 5 A 92.6 22 8.43E- 01 0.6 LYM29 0 12502. 4 o 2.80 9 5.25E- 02 41.4 LYM23 2 13024. 4 A 92.9 31 8.45E- 01 1 LYM13 7 12151. 1 o 2.72 5.81E- 02 37 LYM67 11783. 5 A 92.1 82 8.54E- 01 0.1 LYM57 12012. 2 o 2.26 6 6.86E- 02 14.1 LYM88 12193. 1 A 92.1 08 8.99E- 01 0.1 LYM51 11893. 2 o 2.35 9 7.59E- 02 18.8 LYM20 11716. 3 A 92.2 57 9.05E- 01 0.2 LYM53 11841. 1 o 2.81 7 7.71E- 02 41.9 LYM12 1 13214. 3 A 92.3 09 9.05E- 01 0.3 LYM14 12052. 4 o 2.26 4 8.31E- 02 14 LYM23 2 13022. 1 A 92.2 36 9.28E- 01 0.2 LYM13 2 12276. 1 o 2.27 4 9.43E- 02 14.5 LYM31 11921. 3 A 92.0 86 9.31E- 01 0 LYM13 8 12561. 3 o 2.88 4 9.53E- 02 45.2 LYM27 1 12721. 8 A 92.2 1 9.39E- 01 0.2 LYM14 8 12171. 2 o 2.63 8 1.02E- 01 32.8 LYM99 12243. 1 A 92.1 42 9.40E- 01 0.1 LYM68 11941. 4 o 2.22 3 1.03E- 01 11.9 LYM88 12193. 5 A 92.1 79 9.49E- 01 0.1 LYM11 9 12462. 1 o 3.20 1 1.06E- 01 61.2 LYM12 1 13211. 6 A 92.1 25 9.70E- 01 0.1 LYM11 9 12462. 2 o 2.48 1 1.06E- 01 24.9 LYM69 11853. 5 A 92.0 63 9.73E- 01 0 LYM13 7 12152. 1 o 2.22 6 1.08E- 01 12.1 LYM28 4 12882. 5 A 92.0 91 9.89E- 01 0 LYM68 11941. 3 o 2.67 3 1.27E- 01 34.6 LYM12 5 12931. 5 A 92.0 65 9.94E- 01 0 LYM43 11791. 4 o 2.52 1.37E- 01 26.9 CONTR OL _ A 92.0 48 _ 0 LYM11 1 12252. 2 o 4.44 9 1.69E- 01 124 LYM95 12124. 4 B 0.39 1 1.15E- 01 8.6 LYM13 0 12334. 1 o 2.17 9 1.70E- 01 9.7 LYM69 11852. 2 B 0.38 8 1.69E- 01 7.7 LYM10 5 12294. 3 o 2.35 1.77E- 01 18.3 LYM51 11891. 1 B 0.42 1 3.86E- 01 16.9 LYM30 11913. 5 o 2.49 5 2.05E- 01 25.6 LYM66 11953. 6 B 0.37 6 4.19E- 01 4.3 LYM26 8 12481. 1 o 2.31 1 2.11E- 01 16.4 2016213786 11 Aug 2016 344 Gene name Event I D Mea n P value % incr. vs. cont. Gene name Event I D Mea n P value % incr. vs. cont. LYM67 11782. 6 B 0.40 8 4.83E- 01 13.3 LYM14 8 12173. 1 O 2.29 2.22E- 01 15.3 LYM66 11954. 4 B 0.37 2 5.30E- 01 3.2 LYM10 0 12131. 3 o 2.16 8 2.24E- 01 9.2 LYM99 12244. 1 B 0.36 9 6.38E- 01 2.4 LYM68 11943. 2 o 2.55 9 2.28E- 01 28.9 LYM67 11782. 4 B 0.37 4 6.79E- 01 3.9 LYM15 2 12372. 2 o 2.21 5 2.44E- 01 11.5 LYM99 12243. 1 B 0.36 5 8.06E- 01 1.3 LYM13 7 12154. 5 o 2.42 6 2.44E- 01 22.1 LYM43 11793. 2 B 0.37 4 8.36E- 01 3.9 LYM10 5 12295. 2 o 2.33 2.62E- 01 17.3 LYM31 11924. 4 B 0.36 9 9.06E- 01 2.5 LYM13 0 12332. 2 o 2.42 4 2.81E- 01 22.1 LYM57 12013. 3 B 0.36 3 9.80E- 01 0.8 LYM17 2 12301. 2 o 2.42 5 2.87E- 01 22.1 CONTR OL _ B 0.36 _ 0 LYM29 0 12501. 3 o 2.27 2 2.90E- 01 14.4 LYM95 12124. 4 C 4.28 1 2.01E- 03 22.8 LYM68 11942. 2 o 2.35 5 3.00E- 01 18.6 LYM66 11953. 6 C 4.23 8 4.68E- 03 21.6 LYM62 12022. 1 o 2.26 6 3.17E- 01 14.1 LYM67 11782. 4 C 4.00 6 2.07E- 02 14.9 LYM57 12012. 6 o 2.23 2 3.21E- 01 12.4 LYM99 12244. 1 C 4.00 6 2.94E- 02 14.9 LYM11 1 12254. 4 o 2.46 4 3.28E- 01 24 LYM99 12243. 2 C 3.96 9 3.28E- 02 13.9 LYM11 1 12251. 3 o 2.40 4 3.30E- 01 21 LYM66 11954. 4 C 3.91 3 3.91E- 02 12.3 LYM30 11912. 6 o 2.56 3 3.48E- 01 29 LYM69 11852. 2 C 3.93 1 5.24E- 02 12.8 LYM51 11894. 2 o 2.14 3.52E- 01 7.8 LYM67 11782. 5 C 3.87 5 5.34E- 02 11.2 LYM53 11844. 2 o 2.52 1 3.61E- 01 26.9 LYM82 12203. 3 C 3.81 3 9.88E- 02 9.4 LYM13 7 12153. 1 o 2.25 2 3.67E- 01 13.4 LYM88 12194. 2 C 3.79 4 1.08E- 01 00 00* LYM62 12021. 1 o 2.47 2 3.77E- 01 24.5 LYM51 11891. 1 C 3.81 3 1.95E- 01 9.4 LYM13 2 12271. 4 o 2.22 1 4.01E- 01 11.8 LYM53 11841. 1 C 3.74 4 2.04E- 01 7.4 LYM51 11893. 4 o 2.82 2 4.03E- 01 42.1 LYM43 11791. 5 C 3.68 1 2.86E- 01 5.6 LYM11 9 12461. 1 o 3.04 9 4.11E- 01 53.5 LYM99 12241. 1 C 3.65 3.67E- 01 4.7 LYM15 2 12376. 1 o 2.31 4 4.14E- 01 16.5 LYM67 11782. 6 C 4.25 3.83E- 01 21.9 LYM10 0 12134. 1 o 2.21 7 4.18E- 01 11.6 LYM53 11841. 2 C 3.63 1 4.57E- 01 4.2 LYM11 1 12254. 3 o 2.78 9 4.58E- 01 40.4 LYM82 12201. 5 C 3.79 4 4.71E- 01 00 00* LYM10 0 12133. 3 o 2.08 7 4.87E- 01 5.1 2016213786 11 Aug 2016 345 Gene name Event I D Mea n P value % incr. vs. cont. Gene name Event I D Mea n P value % incr. vs. cont. LYM43 11793. 2 C 3.79 4 5.39E- 01 00 00* LYM14 3 12524. 7 O 2.93 4.89E- 01 47.6 LYM67 11783. 5 c 3.59 4 6.03E- 01 3.1 LYM15 2 12372. 1 o 2.57 2 4.90E- 01 29.5 LYM53 11842. 4 c 3.57 5 6.17E- 01 2.6 LYM14 3 12521. 2 o 2.07 3 5.09E- 01 4.4 LYM99 12243. 1 c 3.58 8 6.17E- 01 2.9 LYM14 12051. 4 o 2.14 8 5.20E- 01 8.2 LYM82 12201. 1 c 3.56 9 6.50E- 01 2.4 LYM29 0 12502. 2 o 2.38 3 5.23E- 01 20 LYM51 11893. 4 c 3.59 6.68E- 01 3 LYM67 11783. 5 o 2.30 7 5.53E- 01 16.2 LYM88 12193. 1 c 3.69 4 7.08E- 01 6 LYM26 11824. 6 o 2.20 5 5.59E- 01 11 LYM88 12193. 5 c 3.68 1 7.16E- 01 5.6 LYM13 4 12312. 4 o 2.11 6 5.72E- 01 6.5 LYM69 11854. 2 c 3.55 6 7.53E- 01 2 LYM13 2 12275. 1 o 2.06 7 6.20E- 01 4.1 LYM66 11955. 2 c 3.62 5 8.66E- 01 4 LYM53 11842. 4 o 2.28 9 6.36E- 01 15.3 LYM51 11892. 1 c 3.5 9.37E- 01 0.4 LYM43 11792. 2 o 2.17 4 6.56E- 01 9.4 CONTR OL _ c 3.48 5 _ 0 LYM11 9 12461. 4 o 2.11 5 6.64E- 01 6.5 LYM11 6 13202. 12 D 0.37 9 1.40E- 05 41.9 LYM30 11912. 7 o 2.11 5 6.90E- 01 6.5 LYM67 11782. 6 D 0.33 7 4.39E- 04 26.2 LYM13 8 12562. 1 o 2.12 8 7.14E- 01 7.1 LYM12 8 12641. 5 D 0.36 4 8.83E- 04 36.4 LYM43 11793. 2 o 2.16 2 7.20E- 01 8.9 LYM20 11711. 2 D 0.36 3 8.90E- 04 36.1 LYM30 11913. 3 o 2.06 4 7.61E- 01 3.9 LYM23 8 12764. 8 D 0.33 4 7.05E- 03 25.3 LYM16 2 12231. 3 o 2.09 6 7.65E- 01 5.6 LYM88 12193. 1 D 0.29 8 2.70E- 02 11.8 LYM95 12124. 4 o 2.03 2 7.69E- 01 2.3 LYM12 11871. 3 D 0.29 8 3.76E- 02 11.8 LYM67 11782. 4 o 2.03 5 8.22E- 01 2.5 LYM11 6 13202. 7 D 0.32 1 3.92E- 02 20.2 LYM15 3 12321. 2 o 2.05 1 8.30E- 01 3.3 LYM23 9 13042. 9 D 0.33 5.21E- 02 23.8 LYM15 2 12371. 2 o 2.07 1 8.45E- 01 4.3 LYM53 11841. 1 D 0.30 3 7.50E- 02 13.5 LYM25 4 12474. 4 o 2.10 7 8.58E- 01 6.1 LYM26 11824. 3 D 0.31 2 8.07E- 02 17 LYM26 8 12482. 1 o 2.11 1 8.72E- 01 6.3 LYM99 12243. 1 D 0.34 8 8.18E- 02 30.4 LYM69 11854. 2 o 2.00 6 9.07E- 01 1 LYM31 11923. 4 D 0.28 9 1.00E- 01 8.3 LYM31 11922. 3 o 2.00 8 9.14E- 01 1.1 LYM31 11924. 4 D 0.29 7 1.21E- 01 11.4 LYM15 2 12373. 1 o 2.03 9.27E- 01 2.2 2016213786 11 Aug 2016 346 Gene name Event I D Mea n P value % incr. vs. cont. Gene name Event I D Mea n P value % incr. vs. cont. LYM66 11955. 2 D 0.28 9 1.36E- 01 8.5 LYM69 11852. 4 O 2.00 6 9.29E- 01 1 LYM53 11843. 2 D 0.28 7 1.41E- 01 7.7 LYM26 11824. 5 o 1.99 5 9.47E- 01 0.5 LYM26 11824. 6 D 0.32 7 1.42E- 01 22.4 LYM26 8 12483. 2 o 2.00 7 9.62E- 01 1.1 LYM28 5 12733. 9 D 0.38 1.57E- 01 42.3 CONTR OL _ o 1.98 6 _ 0 LYM20 11716. 5 D 0.29 2 1.84E- 01 9.5 LYM68 11941. 3 P 2.99 1 4.57E- 04 24.7 LYM10 3 12713. 5 D 0.34 6 1.85E- 01 29.6 LYM13 4 12314. 2 P 2.97 4 5.82E- 04 24 LYM24 12061. 4 D 0.32 7 1.93E- 01 22.7 LYM14 8 12174. 1 P 3.46 1 9.68E- 04 44.3 LYM14 12051. 4 D 0.30 7 1.94E- 01 15 LYM57 12013. 5 P 2.90 1 1.36E- 03 20.9 LYM26 11824. 1 D 0.33 8 1.97E- 01 26.8 LYM26 8 12482. 3 P 2.94 5 2.74E- 03 22.8 LYM23 8 12763. 7 D 0.28 3 1.97E- 01 6.1 LYM31 11923. 4 P 2.94 4 2.83E- 03 22.7 LYM66 11954. 4 D 0.32 2 2.07E- 01 20.7 LYM14 0 12264. 1 P 2.79 1 5.07E- 03 16.4 LYM12 11872. 1 D 0.40 4 2.11E- 01 51.6 LYM10 0 12131. 2 P 3.08 5 6.47E- 03 28.6 LYM99 12244. 2 D 0.28 3 2.45E- 01 6.2 LYM13 0 12331. 3 P 2.71 2 1.54E- 02 13 LYM12 11871. 1 D 0.33 4 2.71E- 01 25.1 LYM14 8 12171. 2 P 2.74 8 1.78E- 02 14.5 LYM12 8 12641. 3 D 0.32 5 2.98E- 01 21.7 LYM51 11893. 2 P 2.69 9 1.88E- 02 12.5 LYM23 9 13044. 8 D 0.30 2 3.23E- 01 13 LYM13 8 12561. 1 P 3.15 4 2.51E- 02 31.5 LYM23 2 13024. 6 D 0.29 5 3.63E- 01 10.7 LYM69 11853. 5 P 2.96 8 2.79E- 02 23.7 LYM10 3 12712. 8 D 0.30 5 3.64E- 01 14.3 LYM29 0 12502. 4 P 2.88 6 2.85E- 02 20.3 LYM95 12121. 2 D 0.33 2 3.79E- 01 24.5 LYM17 0 12453. 2 P 2.70 3 2.98E- 02 12.7 LYM95 12124. 4 D 0.28 9 4.16E- 01 8.4 LYM14 3 12524. 2 P 2.94 3 3.25E- 02 22.7 LYM69 11852. 2 D 0.28 1 4.94E- 01 5.2 LYM68 11942. 3 P 2.86 6 3.61E- 02 19.5 LYM15 6 12963. 1 D 0.29 5.11E- 01 8.6 LYM53 11841. 1 P 2.97 1 4.36E- 02 23.9 LYM82 12201. 1 D 0.27 5 5.11E- 01 3.1 LYM57 12012. 2 P 2.62 9 5.16E- 02 9.6 LYM67 11782. 4 D 0.28 8 5.17E- 01 8.1 LYM11 9 12462. 1 P 3.13 4 6.34E- 02 30.7 LYM30 11912. 6 D 0.29 5.57E- 01 8.6 LYM13 7 12152. 1 P 2.59 6 8.59E- 02 8.2 LYM24 12064. 1 D 0.3 5.74E- 01 12.5 LYM62 12022. 1 P 2.63 8.66E- 02 9.6 2016213786 11 Aug 2016 347 Gene name Event I D Mea n P value % incr. vs. cont. Gene name Event I D Mea n P value % incr. vs. cont. LYM26 11824. 5 D 0.30 9 6.01E- 01 15.9 LYM13 8 12561. 3 P 3.01 4 8.88E- 02 25.6 LYM23 2 13024. 7 D 0.33 6.01E- 01 23.6 LYM13 7 12151. 1 P 2.92 6 9.19E- 02 22 LYM30 11912. 7 D 0.27 7 6.08E- 01 3.7 LYM13 7 12153. 1 P 2.70 2 9.26E- 02 12.6 LYM26 11821. 2 D 0.28 6 6.37E- 01 7.3 LYM13 0 12332. 2 P 2.67 3 1.06E- 01 11.4 LYM10 3 12711. 8 D 0.27 3 6.74E- 01 2.5 LYM43 11791. 5 P 2.94 9 1.06E- 01 22.9 LYM10 3 12712. 5 D 0.27 3 6.81E- 01 2.3 LYM43 11791. 4 P 2.73 9 1.20E- 01 14.2 LYM11 6 13204. 4 D 0.31 7.10E- 01 16.3 LYM11 1 12252. 2 P 3.85 1.23E- 01 60.5 LYM62 12023. 2 D 0.27 3 7.33E- 01 2.2 LYM10 5 12295. 2 P 2.70 5 1.58E- 01 12.8 LYM12 8 12641. 1 D 0.27 9 7.45E- 01 4.4 LYM10 0 12131. 3 P 2.55 1 1.66E- 01 6.3 LYM57 12012. 2 D 0.27 1 7.62E- 01 1.4 LYM30 11913. 5 P 2.82 3 1.67E- 01 17.7 LYM66 11953. 6 D 0.27 7.80E- 01 1.3 LYM13 7 12154. 5 P 2.67 4 1.74E- 01 11.5 LYM31 11921. 3 D 0.26 9 8.84E- 01 1 LYM10 0 12134. 1 P 2.62 5 1.75E- 01 9.4 LYM30 11913. 5 D 0.27 3 8.96E- 01 2.4 LYM11 9 12462. 2 P 2.68 3 1.81E- 01 11.8 LYM15 6 12961. 9 D 0.26 8 9.20E- 01 0.6 LYM13 0 12334. 1 P 2.54 3 2.00E- 01 6 LYM14 5 12951. 9 D 0.26 7 9.76E- 01 0.2 LYM30 11912. 6 P 2.79 4 2.04E- 01 16.5 CONTR OL _ D 0.26 7 _ 0 LYM68 11941. 4 P 2.53 5 2.13E- 01 5.7 LYM26 11824. 3 E 8.81 3 2.28E- 03 8.7 LYM10 5 12294. 3 P 2.68 5 2.22E- 01 11.9 LYM82 12201. 1 E 9.12 5 4.62E- 03 12.5 LYM68 11943. 2 P 2.85 3 2.25E- 01 18.9 LYM28 5 12733. 9 E 9 7.67E- 03 11 LYM26 8 12481. 1 P 2.67 2 2.31E- 01 11.4 LYM24 12064. 1 E 8.62 5 9.72E- 03 6.4 LYM11 1 12251. 3 P 2.68 9 2.51E- 01 12.1 LYM53 11841. 1 E 8.87 5 1.34E- 02 9.4 LYM14 12052. 4 P 2.60 9 2.63E- 01 00 00* LYM12 11872. 1 E 8.56 3 2.18E- 02 5.6 LYM13 4 12312. 4 P 2.51 8 2.68E- 01 4.9 LYM95 12121. 2 E 9.31 3 2.37E- 02 14.8 LYM11 1 12254. 4 P 2.75 3 2.72E- 01 14.7 LYM31 11923. 4 E 8.75 2.50E- 02 7.9 LYM57 12012. 6 P 2.52 4 2.86E- 01 5.2 LYM43 11791. 4 E 8.75 2.50E- 02 7.9 LYM62 12021. 1 P 2.82 7 2.91E- 01 17.8 LYM99 12243. 2 E 8.75 2.50E- 02 7.9 LYM15 2 12372. 2 P 2.62 3 3.12E- 01 9.3 2016213786 11 Aug 2016 348 Gene name Event I D Mea n P value % incr. vs. cont. Gene name Event I D Mea n P value % incr. vs. cont. LYM12 8 12641. 5 E 9.18 8 3.04E- 02 13.3 LYM14 3 12521. 2 P 2.53 9 3.29E- 01 5.8 LYM67 11782. 6 E 8.62 5 4.97E- 02 6.4 LYM53 11844. 2 P 2.85 1 3.42E- 01 18.8 LYM99 12244. 2 E 8.62 5 4.97E- 02 6.4 LYM17 2 12301. 2 P 2.68 8 3.44E- 01 12.1 LYM66 11954. 4 E 8.93 8 5.42E- 02 10.2 LYM67 11783. 5 P 2.69 8 3.48E- 01 12.5 LYM99 12243. 1 E 9.25 7.13E- 02 14.1 LYM51 11893. 4 P 2.94 2 3.50E- 01 22.6 LYM30 11913. 4 E 8.43 8 7.36E- 02 4 LYM13 2 12271. 4 P 2.56 9 3.58E- 01 7.1 LYM66 11953. 6 E 8.43 8 7.36E- 02 4 LYM29 0 12502. 2 P 2.69 4 3.87E- 01 12.3 LYM95 12124. 4 E 8.43 8 7.36E- 02 4 LYM11 9 12461. 1 P 3.08 3 3.95E- 01 28.5 LYM12 8 12641. 3 E 8.81 3 7.63E- 02 8.7 LYM68 11942. 2 P 2.67 3 3.96E- 01 11.4 LYM10 3 12713. 5 E 8.5 1.05E- 01 4.8 LYM15 2 12376. 1 P 2.63 2 4.09E- 01 9.7 LYM26 11824. 6 E 8.5 1.05E- 01 4.8 LYM13 8 12562. 1 P 2.59 4.09E- 01 8 LYM24 12061. 4 E 9 1.06E- 01 11 LYM29 0 12501. 3 P 2.57 1 4.21E- 01 7.2 LYM23 8 12764. 8 E 8.68 8 1.12E- 01 7.1 LYM51 11891. 1 P 2.50 1 4.32E- 01 4.2 LYM14 5 12951. 9 E 8.37 5 1.13E- 01 3.3 LYM11 1 12254. 3 P 2.96 4 4.42E- 01 23.6 LYM88 12194. 2 E 8.56 3 1.73E- 01 5.6 LYM14 3 12524. 7 P 2.92 8 4.42E- 01 22 LYM26 11824. 1 E 8.75 1.74E- 01 7.9 LYM95 12124. 4 P 2.48 5 4.88E- 01 3.6 LYM20 11711. 2 E 8.93 8 1.81E- 01 10.2 LYM14 8 12173. 1 P 2.55 1 4.89E- 01 6.3 LYM14 12051. 4 E 8.81 3 2.22E- 01 8.7 LYM15 2 12372. 1 P 2.81 6 5.25E- 01 17.4 LYM11 6 13202. 12 E 8.37 5 2.33E- 01 3.3 LYM10 0 12133. 3 P 2.50 1 5.25E- 01 4.3 LYM99 12241. 1 E 8.37 5 2.33E- 01 3.3 LYM26 11824. 6 P 2.61 9 5.33E- 01 9.2 LYM30 11912. 6 E 8.31 3 2.38E- 01 2.5 LYM11 1 12251. 1 P 2.46 3 5.41E- 01 2.7 LYM23 9 13042. 9 E 8.43 8 2.80E- 01 4 LYM51 11894. 2 P 2.46 2 5.54E- 01 2.6 LYM69 11852. 2 E 8.93 8 2.86E- 01 10.2 LYM14 12051. 4 P 2.53 4 5.68E- 01 5.6 LYM12 8 12641. 1 E 8.5 3.24E- 01 4.8 LYM10 5 12297. 1 P 2.47 5 5.86E- 01 3.1 LYM57 12012. 2 E 8.5 3.24E- 01 4.8 LYM13 2 12276. 1 P 2.53 2 5.96E- 01 5.5 LYM31 11921. 3 E 8.55 4 3.53E- 01 5.5 LYM43 11792. 2 P 2.56 4 6.02E- 01 6.9 2016213786 11 Aug 2016 349 Gene name Event I D Mea n P value % incr. vs. cont. Gene name Event I D Mea n P value % incr. vs. cont. LYM66 11955. 2 E 8.93 8 3.68E- 01 10.2 LYM30 11913. 3 P 2.45 6 6.49E- 01 2.4 LYM88 12193. 1 E 8.62 5 3.80E- 01 6.4 LYM16 2 12231. 3 P 2.49 6 6.50E- 01 4.1 LYM66 11952. 2 E 8.37 5 4.66E- 01 3.3 LYM30 11913. 4 P 2.47 2 6.77E- 01 3 LYM23 2 13024. 7 E 8.31 3 4.68E- 01 2.5 LYM11 9 12461. 4 P 2.51 5 7.10E- 01 4.9 LYM99 12244. 1 E 8.43 8 4.71E- 01 4 LYM15 2 12371. 2 P 2.50 8 7.20E- 01 4.5 LYM31 11924. 4 E 8.56 3 4.80E- 01 5.6 LYM53 11842. 4 P 2.58 9 7.25E- 01 7.9 LYM51 11891. 1 E 8.25 5.02E- 01 1.7 LYM43 11793. 2 P 2.53 5 7.25E- 01 5.7 LYM53 11842. 4 E 8.25 5.02E- 01 1.7 LYM30 11912. 7 P 2.44 2 7.59E- 01 1.8 LYM62 12023. 5 E 8.25 5.02E- 01 1.7 LYM15 2 12373. 1 P 2.50 3 7.68E- 01 4.3 LYM62 12023. 2 E 8.68 8 5.52E- 01 7.1 LYM26 11824. 5 P 2.42 8 7.79E- 01 1.2 LYM12 11873. 4 E 8.43 8 5.87E- 01 4 LYM13 2 12275. 1 P 2.42 4 8.07E- 01 1.1 LYM12 11871. 3 E 8.18 8 6.37E- 01 1 LYM69 11852. 4 P 2.43 9 8.44E- 01 1.7 LYM53 11843. 2 E 8.18 8 6.37E- 01 1 LYM31 11922. 3 P 2.42 5 8.59E- 01 1.1 LYM67 11782. 4 E 8.43 8 6.63E- 01 4 LYM25 4 12474. 4 P 2.48 7 8.63E- 01 3.7 LYM43 11793. 2 E 8.43 8 7.17E- 01 4 LYM26 8 12482. 1 P 2.47 1 8.81E- 01 3 LYM26 11821. 2 E 8.31 3 7.24E- 01 2.5 LYM66 11954. 4 P 2.47 8 8.96E- 01 3.3 LYM12 11871. 1 E 8.5 7.33E- 01 4.8 LYM15 3 12321. 2 P 2.42 3 9.16E- 01 1 LYM23 9 13044. 8 E 8.18 8 7.69E- 01 1 LYM29 0 12502. 1 P 2.41 1 9.36E- 01 0.5 LYM28 5 12734. 9 E 8.31 3 7.80E- 01 2.5 LYM62 12022. 2 P 2.41 2 9.44E- 01 0.5 LYM43 11791. 5 E 8.12 5 9.18E- 01 0.2 LYM67 11782. 4 P 2.40 6 9.49E- 01 0.3 LYM11 6 13204. 4 E 8.18 8 9.28E- 01 1 LYM16 2 12234. 3 P 2.4 9.95E- 01 0 LYM30 11913. 5 E 8.18 8 9.28E- 01 1 CONTR OL _ P 2.39 9 _ 0 LYM23 2 13024. 6 E 8.12 5 9.39E- 01 0.2 LYM30 11912. 7 E 8.18 8 9.39E- 01 1 LYM67 11782. 5 E 8.12 5 9.62E- 01 0.2 LYM26 11824. 5 E 8.12 5 9.89E- 01 0.2 350

Gene name Event I D Mea n P value % incr. vs. cont. Gene name Event I D Mea n P value % incr. vs. cont. CONTR OL — E 8.10 9 — 0

Table 32. Results of the greenhouse experiments. Provided are the measured values of each tested parameter [parameters (ID.) A-P according to the parameters described in Table 31 above] in plants expressing the indicated polynucleotides. “Ev” = event; “P” = P-value; “Mean ” = the average of measured parameter across replicates. % incr. vs. cont. = percentage of increase versus control (as compared to control). EXAMPLE 11

IMPROVED TRANSGENIC PLANT PERFORMANCE - TISSUE CULTURE

ASSAYS

To analyze the effect of expression of the isolated polynucleotides in plants, plants performance was tested in tissue culture.

Plant growth under favorable conditions in tissue culture using T1 or T2 plants - The experiments used either T2 seeds (T2 experiments herein below) or T1 seeds (T1 experiments herein below). Surface sterilized T1 or T2 seeds were sown in basal media [50% Murashige-Skoog medium (MS) supplemented with 0.8% plant agar as solidifying agent] in the presence of Kanamycin (for selecting only transgenic plants). After sowing, plates were transferred for 2-3 days for stratification at 4 °C and then grown at 25 °C under 12-hour light 12-hour dark daily cycles for 7 to 10 days. At this time point, at T2 experiments seedlings randomly chosen were carefully transferred to plates containing 0.5 MS media. Each plate contained 5 seedlings of the same transgenic event, and 3-4 different plates (replicates) for each event. For each polynucleotide of the invention at least four independent transformation events were analyzed from each construct. Plants expressing the polynucleotides of the invention were compared to the average measurement of the control plants (empty vector or GUS reporter gene under the same promoter) used in the same experiment. Alternatively, at T1 experiments seedlings randomly chosen were carefully transferred to plates containing 0.5 MS media. Each plate contained 5 T1 seedlings representing 5 independent transgenic events, and 3-4 different plates (total of 15-20 events). Plants expressing the polynucleotides of the invention were compared to the average 2016213786 11 Aug 2016 351 measurement of the control plants (empty vector or GUS reporter gene under the same promoter) used in the same experiment.

Plant growth under low nitrogen conditions in Tissue culture using T2 plants - Surface sterilized seeds were sown in basal media [50 % Murashige-Skoog medium 5 (MS) supplemented with 0.8 % plant agar as solidifying agent] in the presence of Kanamycin (used as a selecting agent). After sowing, plates were transferred for 2-3 days for stratification at 4 °C and then grown at 25 °C under 12-hour light 12-hour dark daily cycles for 7 to 10 days. At this time point, seedlings randomly chosen were carefully transferred to plates containing Vi MS media (15 mM N) for the normal 10 nitrogen concentration treatment and 0.75 mM nitrogen for the low nitrogen concentration treatments. Each plate contained 5 seedlings of the same transgenic event, and 3-4 different plates (replicates) for each event. For each polynucleotide of the invention at least four independent transformation events were analyzed from each construct. Plants expressing the polynucleotides of the invention were compared to the 15 average measurement of the control plants (empty vector or GUS reporter gene under the same promoter) used in the same experiment.

For both experiments the same plant parameters were being measured and being described below:

Digital imaging - A laboratory image acquisition system, which consists of a 20 digital reflex camera (Canon EOS 300D) attached with a 55 mm focal length lens (Canon EF-S series), mounted on a reproduction device (Kaiser RS), which included 4 light units (4x150 Watts light bulb) and located in a darkroom, is used for capturing images of plantlets sawn in agar plates.

The image capturing process is repeated every 4 days starting at day 1 till day 25 10. An image analysis system was used, which consists of a personal desktop computer (Intel P4 3.0 GHz processor) and a public domain program - ImageJ 1.39 [Java based image processing program which was developed at the U.S. National Institutes of Health and freely available on the internet at Hypertext Transfer Protocol://rsbweb (dot) nih (dot) gov/]. Images were captured in resolution of 10 Mega Pixels (3888 x 2592 30 pixels) and stored in a low compression JPEG (Joint Photographic Experts Group standard) format. Next, analyzed data was saved to text files and processed using the JMP statistical analysis software (SAS institute). 352

Seedling analysis - Using the digital analysis seedling data was calculated, including leaf area, root coverage and root length.

The relative growth rate for the various seedling parameters was calculated according to the following formulas XVII, VII and XVIII.

Formula XVII:

Relative growth rate of leaf area = Regression coefficient of leaf area along time course.

Formula VII (above) Relative growth rate of root coverage = Regression coefficient of root coverage along time course.

Formula XVIII:

Relative growth rate of root length = Regression coefficient of root length along time course.

At the end of the experiment, plantlets were removed from the media and weighed for the determination of plant fresh weight. Plantlets were then dried for 24 hours at 60 °C, and weighed again to measure plant dry weight for later statistical analysis. Growth rate is determined by comparing the leaf area coverage, root coverage and root length, between each couple of sequential photographs, and results were used to resolve the effect of the gene introduced on plant vigor under optimal conditions. Similarly, the effect of the gene introduced on biomass accumulation, under optimal conditions, is determined by comparing the plants' fresh and dry weight to that of control plants (containing an empty vector or the GUS reporter gene under the same promoter). From every construct created, 3-5 independent transformation events were examined in replicates.

Statistical analyses - To identify genes conferring significantly improved plant vigor or enlarged root architecture, the results obtained from the transgenic plants were compared to those obtained from control plants. To identify outperforming genes and constructs, results from the independent transformation events tested were analyzed separately (T2 experiments) or as average of events (T1 experiments). To evaluate the effect of a gene event (T2 experiments) or gene (T1 experiment) over a control the data is analyzed by Student’s t-test and the p value is calculated. Results were considered significant if p < 0.1. The JMP statistics software package was used (Version 5.2.1, SAS Institute Inc., Cary, NC, USA). 2016213786 11 Aug 2016 353

Tables 33, 35 and 37 specify the parameters measured in plants in the tissue culture assays (T2 plants, T1 plants and low nitrogen T2 plants).

Experimental Results

Plants expressing the polynucleotides of the invention were assayed for a 5 number of commercially desired traits. In cases where a certain event appears more than once, the event was tested in several independent experiments.

Table 33

Measured parameters at the tissue culture assay (T2 experiment) for transformed 10 agriculture improving trait genes

Tested Parameters ID Dry Weight (gr) A Fresh Weight (gr) B RGR Of Root Coverage C Roots Coverage TP3 (cm2) D RGR Of Roots Length E Roots Length TP3 (cm) F Leaf Area TP3 (cm) G RGR Of Leaf Area H

Table 33: Provided are the identification (ID) letters of each of the Tested Parameters. TP3 -Time Point 3; RGR- Relative Growth Rate. 15 Table 34

Results obtained in a 12 experiment at the tissue culture assay

Gene name Event / D Mea n P value % incr. vs. cent. Gene name Event I D Mea n P value % incr. vs. cont. LYM37 11801. 2 A 0.00 7 4.96E- 04 60.3 LYMl 1160 2.6 H 0.10 4 0.00E +00 124 LYM34 11902. 2 A 0.00 6 2.28E- 02 33.5 LYM132 1227 5.3 H 0.08 5 0.00E +00 82.4 LYM34 11904. 3 A 0.00 6 7.24E- 02 27.6 LYM178 1216 4.3 H 0.10 6 0.00E +00 128.4 LYM34 11901. 1 A 0.00 5 8.11E-02 15.8 LYM132 1227 1.4 H 0.07 5 1.00E- 06 61.2 LYM35 11813. 5 A 0.00 5 8.90E- 02 14.7 LYMl 1160 1.1 H 0.07 4 2.00E- 06 60.1 CONTR OL A 0.00 5 0 LYM178 1216 3.3 H 0.09 3 2.00E- 06 100.8 LYM34 11904. 3 B 0.11 9 8.41E-02 27.7 LYM132 1227 6.1 H 0.08 6 6.00E- 06 84.4 LYM35 11813. 5 B 0.10 9 9.32E- 02 16.8 LYM134 1231 4.2 H 0.07 5 3.10E- 05 61.1 CONTR OL B 0.09 3 0 LYM6 1173 6.1 H 0.07 7 5.10E- 05 66 2016213786 11 Aug 2016 354 Gene name Event I D Mea n P value % incr. vs. cent. Gene name Event I D Mea n P value % incr. vs. cent. LYM37 11801. 1 C 0.69 7 1.40E- 05 69.9 LYM268 1248 2.1 H 0.07 2 6.60E- 05 54.4 LYM12 11874. 1 c 0.59 3.88E- 02 43.9 LYM129 1257 3.5 H 0.07 8 1.22E- 04 68.6 LYM35 11813. 5 c 0.51 8 7.38E- 02 26.2 LYM1 1160 3.2 H 0.06 6 5.10E- 04 42.6 LYM37 11803. 2 c 0.52 7 8.20E- 02 28.3 LYM268 1248 3.2 H 0.07 2 5.20E- 04 54.1 LYM34 11902. 2 c 0.50 5 9.84E- 02 23.1 LYM134 1231 3.2 H 0.09 8 8.99E- 04 111.5 CONTR OL c 0.41 0 LYM178 1216 4.2 H 0.06 4 1.35E- 03 37.5 LYM37 11801. 1 D 6.17 8 1.90E- 05 69.5 LYM5 1243 2.1 H 0.07 2 1.67E- 03 54.4 LYM41 11831. 5 D 4.33 1 7.99E- 02 18.8 LYM268 1248 3.4 H 0.07 3.94E- 03 50.7 CONTR OL D 3.64 5 0 LYM268 1248 2.3 H 0.06 4 5.44E- 03 36.9 LYM37 11801. 1 E 0.5 9.40E- 05 48.1 LYM5 1243 5.1 H 0.06 7 9.04E- 03 44.9 LYM34 11902. 4 E 0.43 4 4.61E- 03 28.8 LYM6 1173 5.1 H 0.06 4 1.69E- 02 37.6 LYM12 11871. 1 E 0.42 1 1.67E- 02 24.7 LYM6 1173 5.2 H 0.05 9 1.93E- 02 27.1 LYM12 11874. 1 E 0.47 5 2.60E- 02 40.6 LYM129 1257 2.2 H 0.05 9 2.39E- 02 26.6 LYM12 11873. 4 E 0.43 7 2.78E- 02 29.5 LYM129 1257 1.3 H 0.06 1 5.64E- 02 31 LYM12 11872. 1 E 0.41 9 3.43E- 02 24.3 LYM132 1227 3.2 H 0.06 1 6.13E- 02 32.2 LYM37 11803. 2 E 0.44 4.37E- 02 30.4 LYM1 1160 2.1 H 0.05 7 6.26E- 02 21.7 LYM134 12312. 3 E 0.41 3 4.44E- 02 22.3 LYM5 1243 6.2 H 0.05 9 8.93E- 02 27.3 LYM178 12164. 2 E 0.45 5 4.69E- 02 34.8 CONTR OL H 0.04 6 0 LYM34 11903. 3 E 0.41 8 4.86E- 02 24 LYM236 1259 4.3 A 0.00 8 1.51E- 03 116.1 LYM41 11831. 1 E 0.41 5.41E- 02 21.5 LYM254 1247 1.1 A 0.00 8 2.78E- 03 98.7 LYM178 12161. 1 E 0.40 3 7.68E- 02 19.6 LYM162 1223 1.1 A 0.00 6 3.13E- 03 46.6 LYM41 11833. 1 E 0.41 5 8.54E- 02 23.1 LYM42 1199 2.2 A 0.00 6 4.31E- 03 47.3 CONTR OL E 0.33 7 0 LYM148 1217 1.2 A 0.00 6 5.66E- 03 53.1 LYM37 11801. 1 F 6.04 7 6.62E- 04 37 LYM170 1245 2.3 A 0.00 8 1.06E- 02 100.6 LYM34 11902. 4 F 5.24 6 9.78E- 04 18.8 LYM250 1261 3.2 A 0.00 8 1.81E- 02 93.6 LYM41 11831. 5 F 5.45 2.57E- 03 23.5 LYM172 1230 1.3 A 0.00 5 2.24E- 02 40.8 LYM41 11831. F 5.58 4.3 IE- 26.5 LYM206 1260 A 0.00 2.33E- 69.1 2016213786 11 Aug 2016 355 Gene name Event I D Mea n P value % incr. vs. cent. Gene name Event I D Mea n P value % incr. vs. cent. 1 3 03 3.2 1 02 LYM12 11873. 4 F 5.77 6 1.16E- 02 30.8 LYM236 1259 2.3 A 0.01 1 2.33E- 02 194.5 LYM37 11801. 2 F 5.41 1 1.89E- 02 22.6 LYM140 1226 1.4 A 0.00 5 2.36E- 02 37.6 LYM178 12161. 1 F 5.19 7 2.62E- 02 17.7 LYM236 1259 1.1 A 0.00 8 4.87E- 02 94.9 LYM35 11813. 5 F 5.42 1 3.01E- 02 22.8 LYM172 1230 4.1 A 0.00 6 5.05E- 02 46 LYM12 11871. 1 F 4.91 3.40E- 02 11.2 LYM170 1245 3.3 A 0.00 8 5.28E- 02 102.6 LYM34 11903. 3 F 5.27 1 5.80E- 02 19.4 LYM99 1224 4.2 A 0.00 5 5.35E- 02 31.8 LYM12 11872. 1 F 4.93 3 9.08E- 02 11.8 LYM176 1238 5.1 A 0.00 8 6.09E- 02 92.9 LYM37 11803. 2 F 5.32 5 9.97E- 02 20.6 LYM254 1247 3.1 A 0.00 6 6.78E- 02 51.1 CONTR OL F 4.41 4 0 LYM206 1260 1.3 A 0.00 5 8.81E- 02 23.5 LYM34 11902. 2 G 0.51 1.12E- 04 35.6 CONTR OL A 0.00 4 0 LYM132 12271. 4 G 0.53 5 1.40E- 04 42.2 LYM250 1261 3.2 B 0.15 5 1.17E- 03 115.8 LYM37 11801. 1 G 0.53 3.38E- 03 41.1 LYM170 1245 2.3 B 0.15 1.88E- 03 108.2 LYM35 11813. 5 G 0.53 2 4.76E- 03 41.6 LYM140 1226 1.4 B 0.10 3 2.97E- 03 42.9 LYM41 11831. 5 G 0.48 5 5.92E- 03 29.1 LYM254 1247 1.1 B 0.14 6 4.61E- 03 103.2 LYM34 11904. 3 G 0.51 1 1.03E- 02 36 LYM42 1199 2.2 B 0.11 2 6.00E- 03 55 LYM37 11801. 2 G 0.55 3 2.50E- 02 All LYM236 1259 4.3 B 0.16 6 7.83E- 03 130.6 LYM35 11814. 1 G 0.49 6 4.22E- 02 31.9 LYM148 1217 1.2 B 0.11 8 9.52E- 03 63.8 LYM37 11803. 2 G 0.46 4.24E- 02 22.3 LYM99 1224 4.2 B 0.09 4 1.23E- 02 31 LYM35 11812. 4 G 0.49 5 4.88E- 02 31.7 LYM89 1221 1.2 B 0.15 7 1.54E- 02 117.7 LYM37 11802. 2 G 0.69 8 5.08E- 02 85.6 LYM162 1223 1.1 B 0.10 9 1.59E- 02 52 LYM178 12161. 1 G 0.43 2 5.38E- 02 15 LYM236 1259 2.3 B 0.21 8 1.74E- 02 202.4 LYM41 11831. 1 G 0.46 7 8.64E- 02 24.4 LYM172 1230 4.1 B 0.11 8 2.52E- 02 63.6 LYM178 12163. 3 G 0.43 9 8.80E- 02 16.7 LYM176 1238 5.1 B 0.14 7 2.76E- 02 103.9 LYM37 11803. 1 G 0.44 5 9.23E- 02 18.3 LYM254 1247 3.1 B 0.12 3 3.29E- 02 70.5 CONTR OL G 0.37 6 0 LYM206 1260 3.2 B 0.13 9 3.64E- 02 92.4 LYM37 11802. 2 H 0.07 1 8.35E- 04 82.3 LYM236 1259 1.1 B 0.14 8 3.71E- 02 105.8 2016213786 11 Aug 2016 356 Gene name Event I D Mea n P value % incr. vs. cent. Gene name Event I D Mea n P value % incr. vs. cent. LYM37 11801. 1 H 0.05 6 2.75E- 03 44.2 LYM170 1245 3.3 B 0.15 6 4.30E- 02 116.8 LYM37 11801. 2 H 0.05 4 6.30E- 03 40.3 LYM250 1261 4.1 B 0.09 4.32E- 02 24.8 LYM35 11813. 5 H 0.05 1 1.52E- 02 32.4 LYM172 1230 2.2 B 0.08 9 4.68E- 02 23.7 LYM132 12271. 4 H 0.05 2 1.70E- 02 34.1 LYM250 1261 3.4 B 0.09 9 4.78E- 02 37 LYM37 11803. 2 H 0.05 2.33E- 02 29.6 LYM206 1260 1.3 B 0.1 5.38E- 02 39.3 LYM35 11812. 4 H 0.05 2 2.59E- 02 33.2 LYM140 1226 1.2 B 0.08 9 5.71E- 02 23.4 LYM34 11902. 2 H 0.04 9 2.97E- 02 27.4 LYM206 1260 3.1 B 0.08 8 6.78E- 02 22.5 LYM34 11904. 3 H 0.05 7.81E- 02 28.4 LYM170 1245 3.2 B 0.09 4 7.55E- 02 30.7 LYM12 11874. 1 H 0.05 9.07E- 02 30.1 LYM206 1260 2.1 B 0.12 3 8.33E- 02 70.1 LYM35 11814. 1 H 0.04 7 9.82E- 02 22.5 LYM170 1245 2.4 B 0.12 8 8.37E- 02 77.1 CONTR OL H 0.03 9 0 LYM140 1226 2.2 B 0.09 9.03E- 02 24.7 LYM82 12203. 5 A 0.01 1 1.26E- 03 111.5 LYM176 1238 4.1 B 0.09 6 9.40E- 02 33 LYM268 12482. 1 A 0.00 7 2.56E- 03 34.2 CONTR OL B 0.07 2 0 LYM82 12201. 2 A 0.00 8 5.53E- 03 51.6 LYM172 1230 1.3 C 0.90 9 0.00E +00 131.8 LYM5 12436. 1 A 0.00 6 8.15E- 03 24.2 LYM176 1238 4.1 C 0.86 9 0.00E +00 121.6 LYM86 12183. 1 A 0.00 7 8.76E- 03 43.6 LYM206 1260 3.2 C 0.96 2 0.00E +00 145.4 LYM129 12573. 1 A 0.01 1.15E- 02 91.5 LYM236 1259 1.1 C 1.00 8 0.00E +00 157.2 LYM268 12484. 2 A 0.00 9 2.45E- 02 73.6 LYM236 1259 2.3 C 0.99 9 0.00E +00 154.8 LYM268 12483. 4 A 0.01 4 2.66E- 02 180.3 LYM236 1259 4.3 C 0.86 2 0.00E +00 119.8 LYM129 12572. 2 A 0.00 7 2.78E- 02 38.7 LYM250 1261 3.2 C 0.93 7 0.00E +00 139 LYM8 11984. 1 A 0.01 1 3.56E- 02 125.9 LYM254 1247 1.1 C 0.83 2 0.00E +00 112.2 LYM86 12183. 3 A 0.00 7 9.36E- 02 39.7 LYM170 1245 2.4 C 0.78 4 1.00E- 06 100.1 CONTR OL A 0.00 5 0 LYM170 1245 2.3 C 0.82 6 1.00E- 05 110.8 LYM268 12482. 1 B 0.13 8 1.55E- 03 47.8 LYM170 1245 3.2 C 0.78 9 1.00E- 05 101.4 LYM82 12203. 5 B 0.18 9 5.29E- 03 102.1 LYM148 1217 1.2 C 0.80 9 1.10E-05 106.5 LYM86 12183. 1 B 0.14 2 1.04E- 02 51.8 LYM206 1260 2.1 C 0.89 5 1.10E-05 128.4 LYM129 12573. B 0.17 1.16E- 83.7 LYM172 1230 C 0.71 1.30E- 81 2016213786 11 Aug 2016 357 Gene name Event I D Mea n P value % incr. vs. cent. Gene name Event I D Mea n P value % incr. vs. cent. 1 1 02 4.1 05 LYM268 12484. 2 B 0.14 6 1.19E- 02 56.8 LYM162 1223 1.1 C 0.89 8 1.70E- 05 129 LYM82 12201. 2 B 0.13 3 1.75E- 02 42.9 LYM162 1223 1.2 c 0.85 6 2.40E- 05 118.5 LYM268 12483. 4 B 0.24 3 2.03E- 02 160.1 LYM176 1238 1.3 c 0.69 1 4.30E- 05 76.2 LYM129 12572. 2 B 0.12 6 4.67E- 02 35.3 LYM250 1261 4.1 c 0.74 8.00E- 05 88.8 LYM5 12436. 1 B 0.11 7.62E- 02 18.2 LYM206 1260 3.3 c 0.73 6 1.02E- 04 87.7 CONTR OL B 0.09 3 0 LYM89 1221 4.2 c 0.71 3 1.44E- 04 81.9 LYM268 12483. 4 C 1.19 3 0.00E +00 184.9 LYM176 1238 5.1 c 0.84 7 1.46E- 04 116 LYM82 12203. 5 C 0.93 3 1.00E- 06 122.9 LYM172 1230 2.2 c 0.77 7 1.54E- 04 98.2 LYM8 11984. 1 C 0.84 6 1.20E- 05 102.1 LYM254 1247 1.2 c 0.65 7 2.37E- 04 67.6 LYM82 12203. 2 C 1.04 7 2.30E- 05 149.9 LYM99 1224 4.2 c 0.66 5 5.09E- 04 69.6 LYM268 12484. 2 C 0.74 9 4.40E- 05 79 LYM250 1261 1.3 c 0.66 6 5.70E- 04 69.8 LYM5 12436. 2 C 0.70 8 1.17E- 04 69 LYM172 1230 1.2 c 0.62 1 6.43E- 04 58.4 LYM44 11884. 3 C 0.68 3 5.09E- 04 63.2 LYM170 1245 3.3 c 0.70 9 6.67E- 04 80.9 LYM86 12183. 3 C 0.59 9 4.64E- 03 43.1 LYM89 1221 4.1 c 0.69 4 7.89E- 04 111 LYM129 12573. 1 C 0.63 4 4.95E- 03 51.5 LYM236 1259 2.4 c 0.69 8 8.40E- 04 78 LYM129 12572. 2 C 0.61 6 5.99E- 03 All LYM42 1199 2.2 c 0.75 8.94E- 04 91.4 LYM86 12182. 3 C 0.58 5 1.21E- 02 39.6 LYM140 1226 1.2 c 0.63 4 1.55E- 03 61.8 LYM268 12481. 3 C 0.65 5 1.25E- 02 56.5 LYM89 1221 4.3 c 0.63 6 1.76E- 03 62.3 LYM5 12436. 1 C 0.59 2 1.26E- 02 41.3 LYM89 1221 1.2 c 0.69 1.81E- 03 76 LYM44 11882. 1 C 0.61 2 1.33E- 02 46.2 LYM162 1223 3.2 c 0.59 4 2.55E- 03 51.5 LYM268 12482. 1 C 0.55 8 3.20E- 02 33.2 LYM99 1224 4.1 c 0.63 1 3.12E- 03 60.9 LYM44 11885. 3 C 0.54 6 5.94E- 02 30.3 LYM140 1226 1.4 c 0.61 4 3.48E- 03 56.5 CONTR OL C 0.41 9 0 LYM254 1247 2.3 c 0.60 9 4.02E- 03 55.4 LYM268 12483. 4 D 10.3 19 2.40E- 05 190.3 LYM162 1223 4.3 c 0.59 1 4.28E- 03 50.8 LYM5 12436. 2 D 6.06 9 1.53E- 03 70.7 LYM3 1204 1.2 c 0.58 4 5.59E- 03 48.9 LYM44 11884. 3 D 5.87 6 2.29E- 03 65.3 LYM99 1224 1.1 c 0.57 3 6.37E- 03 46.2 2016213786 11 Aug 2016 358 Gene name Event I D Mea n P value % incr. vs. cent. Gene name Event I D Mea n P value % incr. vs. cent. LYM82 12203. 5 D 8.17 2.69E- 03 129.8 LYM89 1221 4.4 C 0.60 1 7.47E- 03 53.3 LYM268 12484. 2 D 6.62 7 3.76E- 03 86.4 LYM250 1261 3.4 c 0.59 8 7.72E- 03 52.6 LYM86 12183. 3 D 5.31 3 3.87E- 03 49.5 LYM290 1250 2.1 c 0.63 5 8.21E- 03 61.9 LYM86 12182. 3 D 4.99 6 8.33E- 03 40.6 LYM290 1250 1.3 c 0.63 6 1.00E- 02 62.3 LYM129 12572. 2 D 5.33 6 1.25E- 02 50.1 LYM148 1217 3.5 c 0.60 8 1.17E- 02 55.2 LYM129 12573. 1 D 5.39 1.80E- 02 51.6 LYM148 1217 3.1 c 0.55 5 1.44E- 02 41.6 LYM5 12436. 1 D 5.20 3 2.16E- 02 46.4 LYM206 1260 1.3 c 0.60 6 1.63E- 02 54.7 LYM82 12203. 2 D 9.17 2 2.69E- 02 158 LYM148 1217 2.1 c 0.54 4 3.03E- 02 38.8 LYM8 11984. 1 D 7.27 7 3.07E- 02 104.7 LYM254 1247 4.3 c 0.54 3 3.66E- 02 38.4 LYM44 11885. 3 D 4.76 8 3.08E- 02 34.1 LYM3 1204 1.1 c 0.53 1 3.68E- 02 35.5 LYM268 12482. 1 D 4.71 4 3.75E- 02 32.6 LYM99 1224 3.2 c 0.58 4 4.06E- 02 48.9 LYM44 11882. 1 D 5.20 5 6.64E- 02 46.4 CONTR OL c 0.39 2 0 CONTR OL D 3.55 5 0 LYM176 1238 4.1 D 7.65 5 0.00E +00 132.7 LYM268 12483. 4 E 0.52 9 1.08E- 02 41.8 LYM172 1230 4.1 D 6.29 8 1.30E- 05 91.4 LYM44 11884. 3 E 0.50 4 2.21E- 02 35.2 LYM170 1245 2.4 D 6.86 3 3.10E- 05 108.6 LYM82 12203. 2 E 0.52 8 2.55E- 02 41.7 LYM176 1238 1.3 D 6.03 9 3.20E- 05 83.6 LYM82 12203. 5 E 0.49 4 6.19E- 02 32.5 LYM254 1247 1.2 D 5.66 3 1.13E- 04 72.2 LYM86 12182. 3 E 0.47 4 7.22E- 02 27.2 LYM172 1230 1.3 D 7.85 3 3.12E- 04 138.7 LYM86 12183. 3 E 0.46 9 9.75E- 02 25.7 LYM172 1230 1.2 D 5.34 7 3.95E- 04 62.5 CONTR OL E 0.37 3 0 LYM254 1247 1.1 D 7.28 5.95E- 04 121.3 LYM268 12483. 4 F 6.55 1 4.20E- 05 48.7 LYM99 1224 1.1 D 4.88 5 1.02E- 03 48.5 LYM82 12203. 5 F 6.54 4.30E- 05 48.4 LYM162 1223 3.2 D 5.09 5 1.13E- 03 54.9 LYM82 12203. 2 F 6.36 6 2.44E- 04 44.5 LYM236 1259 1.1 D 8.65 5 1.52E- 03 163.1 LYM44 11884. 3 F 5.87 5 6.63E- 04 33.4 LYM236 1259 4.3 D 7.79 6 2.20E- 03 137 LYM86 12182. 3 F 5.58 6 2.72E- 03 26.8 LYM162 1223 4.3 D 5.02 3 2.44E- 03 52.7 LYM86 12183. 3 F 5.72 4 3.20E- 03 29.9 LYM206 1260 3.2 D 8.33 2.58E- 03 153.2 LYM8 11983. F 5.55 3.24E- 26.1 LYM148 1217 D 4.69 2.92E- 42.6 2016213786 11 Aug 2016 359 Gene name Event I D Mea n P value % incr. vs. cent. Gene name Event I D Mea n P value % incr. vs. cent. 1 6 03 3.1 2 03 LYM5 12436. 1 F 5.83 1 3.79E- 03 32.3 LYM236 1259 2.3 D 8.56 4 2.99E- 03 160.3 LYM268 12484. 2 F 5.89 8 5.85E- 03 33.9 LYM3 1204 1.2 D 5.08 3 3.81E- 03 54.5 LYM86 12181. 2 F 5.39 6 7.40E- 03 22.5 LYM140 1226 1.4 D 5.32 1 3.93E- 03 61.7 LYM129 12572. 2 F 5.55 5 8.48E- 03 26.1 LYM250 1261 3.2 D 8.02 2 4.46E- 03 143.9 LYM5 12432. 2 F 5.25 2 2.59E- 02 19.2 LYM148 1217 1.2 D 7.07 6 4.80E- 03 115.1 LYM44 11882. 1 F 5.40 9 3.28E- 02 22.8 LYM170 1245 3.2 D 6.92 5.21E- 03 110.4 LYM5 12432. 1 F 5.11 6 3.85E- 02 16.1 LYM89 1221 4.3 D 5.75 6.25E- 03 74.8 LYM44 11885. 4 F 5.08 5 4.84E- 02 15.4 LYM206 1260 3.3 D 6.59 9 8.50E- 03 100.6 LYM129 12573. 1 F 5.08 2 5.14E- 02 15.3 LYM89 1221 4.2 D 6.28 5 1.03E- 02 91 LYM5 12436. 2 F 5.77 2 5.31E- 02 31 LYM99 1224 4.2 D 5.74 2 1.05E- 02 74.5 LYM5 12435. 1 F 5.49 8 6.21E- 02 24.8 LYM250 1261 4.1 D 6.30 8 1.09E- 02 91.8 LYM8 11982. 6 F 5.08 9 7.04E- 02 15.5 LYM170 1245 2.3 D 7.21 1.17E- 02 119.2 LYM8 11984. 1 F 5.99 9 9.59E- 02 36.2 LYM140 1226 1.2 D 5.41 1.38E- 02 64.5 CONTR OL F 4.40 6 0 LYM254 1247 2.3 D 5.26 8 1.47E- 02 60.1 LYM5 12436. 1 G 0.63 8 1.29E- 04 50.3 LYM250 1261 1.3 D 5.79 6 1.51E- 02 76.2 LYM129 12573. 1 G 0.84 9 1.56E- 04 99.9 LYM89 1221 4.1 D 6.21 1.65E- 02 88.8 LYM82 12203. 5 G 0.84 7 2.51E- 04 99.4 LYM172 1230 2.2 D 6.67 2 1.89E- 02 102.8 LYM86 12183. 3 G 0.68 7 4.03E- 04 61.7 LYM206 1260 2.1 D 7.77 2 1.91E- 02 136.2 LYM268 12482. 1 G 0.60 3 5.49E- 04 42 LYM162 1223 1.1 D 7.88 5 1.92E- 02 139.7 LYM268 12483. 4 G 1.05 4 6.89E- 04 148 LYM3 1204 1.1 D 4.68 4 2.07E- 02 42.4 LYM82 12201. 2 G 0.64 3 1.52E- 03 51.4 LYM162 1223 1.2 D 7.35 9 2.76E- 02 123.7 LYM268 12484. 2 G 0.76 8 1.52E- 03 80.8 LYM236 1259 2.4 D 6.22 4 2.84E- 02 89.2 LYM86 12183. 1 G 0.60 2 2.17E- 03 41.6 LYM99 1224 4.1 D 5.46 7 2.84E- 02 66.2 LYM44 11882. 1 G 0.54 4 4.43E- 03 28.1 LYM176 1238 5.1 D 7.50 3 2.87E- 02 128.1 LYM44 11885. 3 G 0.55 2 4.98E- 03 29.9 LYM290 1250 1.2 D 4.36 7 2.94E- 02 32.8 LYM82 12204. 6 G 0.55 8 7.03E- 03 31.3 LYM148 1217 2.1 D 4.71 1 3.20E- 02 43.2 2016213786 11 Aug 2016 360 Gene name Event I D Mea n P value % incr. vs. cent. Gene name Event I D Mea n P value % incr. vs. cent. LYM129 12572. 2 G 0.67 1 7.23E- 03 57.9 LYM170 1245 3.3 D 6.28 2 3.38E- 02 91 LYM44 11884. 3 G 0.53 2 7.42E- 03 25.3 LYM250 1261 3.4 D 5.34 5 3.40E- 02 62.5 LYM5 12436. 2 G 0.54 5 8.39E- 03 28.2 LYM89 1221 1.2 D 6.24 7 4.75E- 02 89.9 LYM8 11984. 1 G 0.84 9 1.84E- 02 99.8 LYM89 1221 4.4 D 4.93 2 4.87E- 02 49.9 LYM86 12182. 3 G 0.52 6 2.43E- 02 23.7 LYM42 1199 2.2 D 6.54 5.04E- 02 98.8 LYM6 11735. 2 G 0.49 8.02E- 02 15.4 LYM148 1217 3.5 D 5.37 2 6.79E- 02 63.3 LYM82 12203. 2 G 0.83 4 8.07E- 02 96.2 LYM254 1247 4.3 D 4.62 5 6.91E- 02 40.6 CONTR OL G 0.42 5 0 LYM290 1250 2.1 D 5.37 7.87E- 02 63.2 LYM129 12573. 1 H 0.08 5 0.00E +00 100.9 LYM206 1260 1.3 D 5.29 6 8.29E- 02 61 LYM268 12483. 4 H 0.10 8 0.00E +00 156.5 CONTR OL D 3.29 0 LYM8 11984. 1 H 0.08 9 0.00E +00 110.3 LYM236 1259 1.1 E 0.59 4 2.26E- 03 47.4 LYM82 12203. 5 H 0.08 8 1.00E- 06 108.4 LYM172 1230 2.2 E 0.59 6 3.04E- 03 47.9 LYM268 12484. 2 H 0.07 4 2.30E- 05 75.8 LYM176 1238 1.3 E 0.57 7 4.24E- 03 43.2 LYM86 12183. 3 H 0.06 6 2.60E- 04 56.3 LYM140 1226 1.2 E 0.56 6 4.95E- 03 40.6 LYM268 12482. 1 H 0.06 2 1.28E- 03 46.3 LYM99 1224 4.1 E 0.56 6 6.16E- 03 40.6 LYM129 12572. 2 H 0.06 5 1.65E- 03 53.7 LYM172 1230 4.1 E 0.56 4 7.50E- 03 40.1 LYM82 12203. 2 H 0.08 7 lJSE- OS 106.5 LYM170 1245 3.2 E 0.56 3 7.87E- 03 39.8 LYM5 12436. 1 H 0.06 2.89E- 03 41.7 LYM170 1245 2.4 E 0.56 7 8.02E- 03 40.8 LYM86 12183. 1 H 0.06 5.56E- 03 41 LYM254 1247 2.3 E 0.55 3 8.60E- 03 37.2 LYM5 12436. 2 H 0.05 9 8.00E- 03 39 LYM148 1217 1.2 E 0.56 3 9.63E- 03 39.9 LYM82 12201. 2 H 0.05 9 8.96E- 03 40.3 LYM206 1260 2.1 E 0.56 2 1.25E- 02 39.6 LYM82 12204. 6 H 0.05 7 1.25E- 02 34.6 LYM99 1224 4.2 E 0.54 1.39E- 02 34 LYM44 11884. 3 H 0.05 6 1.64E- 02 32.6 LYM236 1259 2.3 E 0.55 5 2.06E- 02 37.7 LYM268 12481. 3 H 0.06 1 2.53E- 02 44.7 LYM250 1261 3.2 E 0.54 2 2.10E- 02 34.5 LYM44 11885. 3 H 0.05 6 2.57E- 02 33.6 LYM254 1247 1.2 E 0.55 2.13E- 02 36.6 LYM44 11882. 1 H 0.05 5 3.23E- 02 29.4 LYM206 1260 3.2 E 0.55 7 2.43E- 02 38.4 LYM5 12432. H 0.05 5.25E- 34.7 LYM170 1245 E 0.53 2.59E- 33.7 2016213786 11 Aug 2016 361 Gene name Event I D Mea n P value % incr. vs. cent. Gene name Event I D Mea n P value % incr. vs. cent. 2 1 02 2.3 8 02 LYM86 12182. 3 H 0.05 3 7.08E- 02 24.8 LYM89 1221 4.4 E 0.55 7 2.64E- 02 38.2 CONTR OL H 0.04 2 0 LYM236 1259 2.4 E 0.53 4 2.66E- 02 32.6 LYM89 12214. 3 A 0.00 6 5.91E- 04 43.4 LYM206 1260 3.3 E 0.54 2 2.79E- 02 34.5 LYM250 12611. 3 A 0.00 6 4.67E- 03 44.1 LYM172 1230 1.3 E 0.52 7 3.29E- 02 30.7 CONTR OL A 0.00 4 0 LYM172 1230 1.2 E 0.52 3 3.72E- 02 29.8 LYM250 12611. 3 C 0.72 4 1.68E- 02 39.6 LYM148 1217 3.1 E 0.54 7 3.85E- 02 35.7 CONTR OL C 0.51 9 0 LYM89 1221 4.1 E 0.55 4 3.89E- 02 37.6 LYM250 12611. 3 D 6.63 3 3.09E- 02 40.5 LYM89 1221 1.2 E 0.52 9 3.96E- 02 31.3 CONTR OL D 4.72 1 0 LYM250 1261 4.1 E 0.53 5 4.14E- 02 32.8 LYM250 12611. 3 E 0.53 1 7.01E- 02 18.9 LYM162 1223 1.1 E 0.54 4.51E- 02 34.1 CONTR OL E 0.44 7 0 LYM42 1199 2.2 E 0.52 8 5.37E- 02 31.2 LYM250 12611. 3 F 6.62 7 1.48E- 03 22.7 LYM206 1260 1.3 E 0.51 6.40E- 02 26.6 LYM236 12591. 1 F 6.19 7 1.53E- 02 14.7 LYM250 1261 1.3 E 0.52 5 6.99E- 02 30.4 LYM99 12243. 2 F 6.22 2.59E- 02 15.1 LYM206 1260 4.3 E 0.50 3 7.47E- 02 24.9 CONTR OL F 5.40 2 0 LYM236 1259 4.3 E 0.51 8.71E- 02 26.7 LYM250 12611. 3 G 0.63 3 4.48E- 03 30.7 LYM176 1238 5.1 E 0.52 6 8.97E- 02 30.6 LYM89 12214. 3 G 0.63 2 3.84E- 02 30.6 LYM254 1247 1.1 E 0.51 3 9.45E- 02 27.4 CONTR OL G 0.48 4 0 LYM176 1238 4.1 E 0.50 7 9.46E- 02 26 LYM250 12611. 3 H 0.06 6 4.26E- 02 29.7 CONTR OL E 0.40 3 0 CONTR OL H 0.05 1 0 LYM170 1245 3.2 F 7.24 6 1.00E- 06 71.9 LYM130 12332. 2 A 0.00 8 7.52E- 04 183.7 LYM170 1245 2.4 F 7.20 7 1.00E- 06 71 LYM102 12222. 1 A 0.00 6 1.71E- 03 86.6 LYM236 1259 1.1 F 7.23 9 1.00E- 06 71.7 LYM130 12334. 1 A 0.00 7 2.90E- 03 123.4 LYM148 1217 1.2 F 6.95 1 3.00E- 06 64.9 LYM138 12561. 3 A 0.00 5 3.10E- 03 74.1 LYM172 1230 1.3 F 7.00 6 3.00E- 06 66.2 LYM141 12404. 2 A 0.00 6 8.08E- 03 106.7 LYM99 1224 4.2 F 6.7 3.00E- 06 59 LYM106 12142. 2 A 0.00 4 1.83E- 02 48.1 LYM176 1238 1.3 F 7.08 9 4.00E- 06 68.2 2016213786 11 Aug 2016 362 Gene name Event I D Mea n P value % incr. vs. cent. Gene name Event I D Mea n P value % incr. vs. cent. LYM138 12566. 1 A 0.00 4 1.99E- 02 46.4 LYM176 1238 4.1 F 7.17 1 3.30E- 05 70.1 LYM100 12133. 3 A 0.00 5 2.31E-02 62.3 LYM99 1224 4.1 F 6.71 5 3.40E- 05 59.3 LYM141 12404. 3 A 0.00 8 3.47E- 02 151 LYM254 1247 2.3 F 6.57 3 3.80E- 05 56 LYM106 12144. 3 A 0.00 5 3.82E- 02 59 LYM172 1230 4.1 F 6.85 2 4.90E- 05 62.6 LYM119 12462. 1 A 0.00 4 6.49E- 02 46.4 LYM140 1226 1.2 F 6.62 3 5.40E- 05 57.1 LYM130 12331. 3 A 0.00 4 7.03E- 02 48.1 LYM170 1245 2.3 F 6.77 7 6.70E- 05 60.8 LYM137 12152. 1 A 0.00 8 7.19E- 02 160.3 LYM3 1204 1.1 F 6.22 8 7.30E- 05 47.8 LYM100 12131. 2 A 0.00 4 7.74E- 02 45.6 LYM148 1217 3.5 F 6.63 9 7.60E- 05 57.5 LYM102 12221. 2 A 0.00 7 8.15E- 02 117.6 LYM206 1260 3.2 F 7.10 5 1.19E- 04 68.6 LYM130 12332. 1 A 0.00 4 9.91E- 02 48.1 LYM254 1247 1.1 F 6.78 1 1.27E- 04 60.9 CONTR OL A 0.00 3 0 LYM89 1221 4.2 F 7.10 8 1.46E- 04 68.6 LYM141 12404. 2 B 0.13 4 1.20E- 05 79 LYM206 1260 3.1 F 5.79 3 2.05E- 04 37.4 LYM138 12561. 3 B 0.11 4 2.78E- 04 52.9 LYM250 1261 3.2 F 6.78 2 2.08E- 04 60.9 LYM102 12222. 1 B 0.11 3 9.40E- 04 51.4 LYM140 1226 1.4 F 6.07 9 2.18E- 04 44.2 LYM130 12332. 1 B 0.11 7 7.14E- 03 55.7 LYM172 1230 1.2 F 6.31 7 2.83E- 04 49.9 LYM130 12332. 2 B 0.18 9 1.06E- 02 152.1 LYM290 1250 1.2 F 5.64 8 3.03E- 04 34 LYM106 12142. 2 B 0.10 4 1.16E- 02 38.3 LYM290 1250 1.3 F 6.47 2 3.12E- 04 53.6 LYM130 12334. 1 B 0.17 6 1.48E- 02 135 LYM236 1259 4.3 F 7.03 3 3.99E- 04 66.9 LYM141 12404. 3 B 0.15 5 3.07E- 02 106.5 LYM89 1221 1.2 F 6.81 3 4.03E- 04 61.6 LYM138 12566. 1 B 0.1 3.93E- 02 33.3 LYM162 1223 1.1 F 7.20 3 5.06E- 04 70.9 LYM137 12152. 1 B 0.16 4 4.75E- 02 119.7 LYM148 1217 2.1 F 5.78 9 5.46E- 04 37.3 LYM100 12131. 2 B 0.10 8 5.45E- 02 44.1 LYM99 1224 1.1 F 5.77 6.25E- 04 36.9 LYM119 12462. 1 B 0.11 6.36E- 02 46.8 LYM206 1260 2.1 F 6.96 6.53E- 04 65.1 LYM113 12444. 5 B 0.14 4 6.90E- 02 91.8 LYM236 1259 2.4 F 6.74 1 7.46E- 04 59.9 CONTR OL B 0.07 5 0 LYM236 1259 2.3 F 6.47 1 8.01E- 04 53.5 LYM137 12153. 1 C 0.75 3.30E- 05 73.3 LYM162 1223 1.2 F 6.80 5 8.61E- 04 61.4 LYM102 12222. C 0.68 3.41E- 57.4 LYM250 1261 F 6.19 1.05E- 47 2016213786 11 Aug 2016 363 Gene name Event I D Mea n P value % incr. vs. cent. Gene name Event I D Mea n P value % incr. vs. cent. 1 1 04 3.4 6 03 LYM141 12404. 3 C 0.73 9 1.80E- 03 70.8 LYM176 1238 5.1 F 6.84 2 1.76E- 03 62.3 LYM137 12152. 1 c 0.63 2.56E- 03 45.6 LYM172 1230 2.2 F 6.85 1 1.79E- 03 62.5 LYM138 12561. 3 c 0.61 5 2.31E-02 42.1 LYM250 1261 4.1 F 6.73 3 1.94E- 03 59.7 LYM130 12332. 2 c 0.58 8 2.32E- 02 36 LYM206 1260 3.3 F 6.66 6 1.97E- 03 58.2 LYM102 12221. 2 c 0.57 8 5.38E- 02 33.7 LYM42 1199 2.2 F 6.76 5 2.50E- 03 60.5 LYM100 12133. 3 c 0.55 5 5.62E- 02 28.4 LYM89 1221 4.1 F 6.51 9 2.76E- 03 54.7 LYM141 12404. 2 c 0.54 7 7.44E- 02 26.5 LYM254 1247 1.2 F 6.58 9 2.87E- 03 56.3 CONTR OL c 0.43 3 0 LYM162 1223 4.3 F 5.85 8 3.38E- 03 39 LYM102 12222. 1 D 5.94 2 1.65E- 03 46.8 LYM3 1204 1.2 F 5.20 3 3.62E- 03 23.4 LYM137 12152. 1 D 5.64 8 2.45E- 03 39.5 LYM250 1261 1.3 F 6.66 4 3.93E- 03 58.1 LYM137 12153. 1 D 6.55 1 2.59E- 03 61.8 LYM206 1260 1.3 F 5.60 5 5.24E- 03 33 LYM100 12133. 3 D 5.09 9 5.27E- 02 26 LYM89 1221 4.3 F 5.83 7 6.12E- 03 38.5 LYM130 12332. 2 D 5.25 3 6.20E- 02 29.8 LYM162 1223 3.2 F 5.95 8 8.02E- 03 41.4 CONTR OL D 4.04 8 0 LYM254 1247 4.3 F 5.75 8 8.41E- 03 36.6 LYM137 12153. 1 E 0.56 9 1.28E- 03 41.7 LYM3 1204 3.2 F 4.99 3 1.23E- 02 18.5 LYM141 12404. 3 E 0.55 9 1.44E- 02 39.3 LYM42 1199 2.1 F 5.51 4 1.45E- 02 30.8 LYM138 12561. 3 E 0.51 3.15E- 02 27 LYM290 1250 2.1 F 5.90 9 2.95E- 02 40.2 LYM102 12222. 1 E 0.50 1 4.11E- 02 24.8 LYM148 1217 3.1 F 6.08 6 3.14E- 02 44.4 LYM100 12133. 3 E 0.49 3 5.35E- 02 22.9 LYM206 1260 4.3 F 4.95 9 4.80E- 02 17.7 CONTR OL E 0.40 1 0 LYM148 1217 4.1 F 4.97 1 6.23E- 02 17.9 LYM138 12561. 3 F 6.64 9 2.18E- 03 31.5 LYM99 1224 3.2 F 5.67 5 6.51E- 02 34.6 LYM100 12133. 3 F 6.46 9 2.22E- 03 27.9 LYM140 1226 2.3 F 5.43 7 8.77E- 02 29 LYM138 12562. 1 F 5.95 7 5.93E- 03 17.8 LYM42 1199 4.1 F 5.06 8 9.11E- 02 20.2 LYM102 12222. 1 F 6.27 6.30E- 03 24 CONTR OL F 4.21 5 0 LYM137 12153. 1 F 6.74 3 9.51E- 03 33.3 LYM254 1247 1.1 G 0.77 3 3.00E- 06 72.9 LYM113 12444. 5 F 5.95 7 1.07E- 02 17.8 LYM99 1224 4.2 G 0.56 9 1.23E- 03 27.3 2016213786 11 Aug 2016 364 Gene name Event I D Mea n P value % incr. vs. cent. Gene name Event I D Mea n P value % incr. vs. cent. LYM102 12221. 2 F 5.89 2 1.12E- 02 16.5 LYM206 1260 1.3 G 0.63 1.78E- 03 40.9 LYM137 12152. 1 F 5.94 9 1.63E- 02 17.6 LYM170 1245 2.3 G 1.02 4 2.21E- 03 129 LYM119 12461. 4 F 5.79 3 2.27E- 02 14.5 LYM176 1238 4.1 G 0.67 5 2.30E- 03 51 LYM130 12332. 2 F 5.63 8 4.49E- 02 11.5 LYM250 1261 3.2 G 0.88 6 2.49E- 03 98.2 LYM113 12443. 1 F 5.68 1 8.19E- 02 12.3 LYM42 1199 2.2 G 0.68 8 4.52E- 03 53.8 CONTR OL F 5.05 8 0 LYM172 1230 1.2 G 0.55 5 4.63E- 03 24.2 LYM102 12222. 1 G 0.64 1 5.60E- 03 61.2 LYM236 1259 4.3 G 0.92 3 4.63E- 03 106.6 LYM138 12561. 3 G 0.56 3 7.37E- 03 41.4 LYM162 1223 1.1 G 0.70 4 5.43E- 03 57.5 LYM130 12332. 2 G 0.73 3 8.67E- 03 84.3 LYM148 1217 1.2 G 0.74 4 6.77E- 03 66.5 LYM137 12152. 1 G 0.75 2 1.54E- 02 88.9 LYM236 1259 2.3 G 1.06 3 6.78E- 03 137.7 LYM141 12404. 2 G 0.53 8 2.41E- 02 35.3 LYM172 1230 4.1 G 0.62 3 7.31E- 03 39.4 LYM138 12566. 1 G 0.5 2.70E- 02 25.7 LYM206 1260 3.2 G 0.74 9 9.52E- 03 67.5 LYM130 12334. 1 G 0.54 4 4.27E- 02 36.6 LYM176 1238 5.1 G 0.99 7 1.09E- 02 123.1 LYM143 12521. 2 G 0.47 8 7.49E- 02 20.2 LYM250 1261 4.2 G 0.57 2 1.38E- 02 27.9 LYM138 12562. 1 G 0.47 6 9.14E- 02 19.7 LYM89 1221 4.2 G 0.54 7 1.62E- 02 22.4 CONTR OL G 0.39 8 0 LYM250 1261 3.4 G 0.68 1 1.94E- 02 52.3 LYM141 12404. 3 H 0.07 7 5.80E- 05 96.5 LYM170 1245 2.4 G 0.76 2.00E- 02 70 LYM102 12222. 1 H 0.06 5 8.00E- 05 65.8 LYM89 1221 1.2 G 0.71 4 2.05E- 02 59.8 LYM137 12152. 1 H 0.07 3 8.50E- 05 85.8 LYM140 1226 1.4 G 0.70 1 2.10E- 02 56.9 LYM130 12332. 2 H 0.06 8 9.70E- 05 73.7 LYM170 1245 3.2 G 0.64 2 2.18E- 02 43.5 LYM137 12153. 1 H 0.06 6 1.26E- 03 66.9 LYM140 1226 2.2 G 0.56 9 2.43E- 02 27.3 LYM138 12561. 3 H 0.05 4 1.01E- 02 37.1 LYM170 1245 3.3 G 0.90 9 2.78E- 02 103.3 LYM141 12404. 2 H 0.05 3 1.35E- 02 34.4 LYM236 1259 1.1 G 0.87 4 2.83E- 02 95.5 LYM102 12221. 2 H 0.05 8 1.40E- 02 46.1 LYM89 1221 4.4 G 0.53 7 2.84E- 02 20.2 LYM130 12334. 1 H 0.05 2 3.72E- 02 30.7 LYM99 1224 3.1 G 0.62 3 3.48E- 02 39.3 LYM138 12562. 1 H 0.05 4.54E- 02 26 LYM89 1221 4.3 G 0.63 6 4.21E- 02 42.2 LYM138 12566. H 0.04 7.16E- 22.8 LYM176 1238 G 0.59 4.33E- 32.1 2016213786 11 Aug 2016 365 Gene name Event I D Mea n P value % incr. vs. cent. Gene name Event I D Mea n P value % incr. vs. cent. 1 8 02 4.2 1 02 LYM100 12133. 3 H 0.04 9 7.66E- 02 25.2 LYM206 1260 3.3 G 0.58 5 4.64E- 02 31 LYM106 12144. 3 H 0.04 9 8.55E- 02 24 LYM140 1226 1.2 G 0.51 5.15E- 02 14 CONTR OL H 0.03 9 0 LYM176 1238 2.2 G 0.58 5 5.38E- 02 30.8 LYM153 12321. 2 A 0.01 2 9.21E- 03 102.4 LYM42 1199 2.1 G 0.64 1 5.45E- 02 43.4 LYM152 12376. 1 A 0.01 1 4.22E- 02 75.2 LYM148 1217 3.5 G 0.67 3 5.74E- 02 50.6 LYM148 12174. 1 A 0.00 8 5.19E- 02 28.7 LYM89 1221 4.1 G 0.63 1 5.75E- 02 41.2 LYM140 12262. 2 A 0.00 8 9.10E- 02 23.8 LYM206 1260 2.1 G 0.73 2 5.75E- 02 63.6 CONTR OL A 0.00 6 0 LYM254 1247 3.1 G 0.56 8 5.82E- 02 27 LYM153 12321. 2 B 0.24 5 2.61E- 03 69.9 LYM3 1204 1.2 G 0.66 5 6.39E- 02 48.8 LYM152 12376. 1 B 0.20 3 8.19E- 02 40.9 LYM42 1199 3.1 G 0.52 8 6.87E- 02 18.2 CONTR OL B 0.14 4 0 LYM172 1230 1.3 G 0.54 9 8.21E- 02 22.8 LYM152 12376. 1 C 1.18 4 0.00E +00 138.6 LYM176 1238 1.3 G 0.56 3 8.39E- 02 26 LYM153 12321. 2 C 1.04 1 1.30E- 05 109.9 LYM290 1250 4.1 G 0.65 9 8.59E- 02 47.4 LYM170 12452. 3 C 0.84 2.70E- 05 69.4 CONTR OL G 0.44 7 0 LYM149 12344. 2 C 0.82 9 5.50E- 05 67.1 LYM170 1245 2.3 H 0.09 9 0.00E +00 113.2 LYM172 12301. 2 C 0.90 5 6.80E- 05 82.3 LYM236 1259 2.3 H 0.10 9 0.00E +00 135.8 LYM174 12412. 1 C 0.80 9 9.50E- 05 63.2 LYM250 1261 3.2 H 0.08 8 0.00E +00 90.5 LYM153 12322. 1 C 0.87 7 1.92E- 04 76.8 LYM236 1259 4.3 H 0.08 8 1.00E- 06 89 LYM172 12301. 3 C 0.86 2.07E- 04 73.3 LYM254 1247 1.1 H 0.07 7 1.00E- 06 64.9 LYM176 12381. 3 C 0.78 1 3.32E- 04 57.5 LYM176 1238 5.1 H 0.09 6 6.00E- 06 106.2 LYM170 12454. 2 C 0.76 6 5.34E- 04 54.4 LYM206 1260 3.2 H 0.07 8 1.20E- 05 68.2 LYM174 12411. 3 C 0.74 8 1.82E- 03 50.8 LYM170 1245 3.3 H 0.09 2 7.00E- 05 97.6 LYM162 12234. 4 C 0.74 3 2.64E- 03 49.7 LYM170 1245 2.4 H 0.07 8 8.10E- 05 67.9 LYM289 12493. 2 C 0.74 7 3.09E- 03 50.6 LYM236 1259 1.1 H 0.08 7 1.34E- 04 87.2 LYM174 12411. 2 C 0.78 5 4.17E- 03 58.3 LYM162 1223 1.1 H 0.07 1 2.54E- 04 52.4 LYM111 12254. 3 C 0.76 4 4.75E- 03 54 LYM89 1221 1.2 H 0.07 1 5.66E- 04 52 2016213786 11 Aug 2016 366 Gene name Event I D Mea n P value % incr. vs. cent. Gene name Event I D Mea n P value % incr. vs. cent. LYM148 12174. 1 C 0.72 5 5.96E- 03 46.1 LYM42 1199 2.2 H 0.06 6 5.77E- 04 43 LYM162 12234. 3 c 0.73 3 1.17E- 02 47.7 LYM206 1260 1.3 H 0.06 5 6.02E- 04 39.1 LYM148 12171. 2 c 0.68 4 2.29E- 02 37.8 LYM148 1217 1.2 H 0.06 9 9.52E- 04 49.3 LYM105 12293. 1 c 0.65 8 2.67E- 02 32.6 LYM176 1238 4.1 H 0.06 6 1.86E- 03 42.7 LYM162 12231. 2 c 0.68 2.78E- 02 37.1 LYM206 1260 2.1 H 0.07 3 2.16E- 03 58.3 LYM174 12414. 3 c 0.65 5.52E- 02 30.9 LYM172 1230 4.1 H 0.06 3 2.61E- 03 36.2 LYM170 12452. 4 c 0.63 6 5.67E- 02 28.2 LYM250 1261 3.4 H 0.06 6 2.68E- 03 43 LYM153 12323. 2 c 0.68 4 5.84E- 02 37.9 LYM170 1245 3.2 H 0.06 4 3.33E- 03 38.6 LYM148 12173. 5 c 0.65 2 6.99E- 02 31.4 LYM140 1226 1.4 H 0.06 6 4.14E- 03 41.3 LYM290 12502. 4 c 0.63 5 7.97E- 02 28.1 LYM99 1224 3.1 H 0.06 3 6.82E- 03 35.1 LYM254 12474. 4 c 0.61 7 8.58E- 02 24.4 LYM99 1224 4.2 H 0.05 9 7.05E- 03 27.3 LYM148 12173. 1 c 0.63 2 9.21E- 02 27.3 LYM89 1221 4.1 H 0.06 5 7.10E- 03 40.5 CONTR OL c 0.49 6 0 LYM206 1260 3.3 H 0.06 1 8.74E- 03 31.6 LYM152 12376. 1 D 10.1 84 0.00E +00 134.7 LYM250 1261 4.2 H 0.06 9.60E- 03 29.4 LYM170 12452. 3 D 7.08 7.80E- 05 63.2 LYM42 1199 2.1 H 0.06 4 1.49E- 02 37.4 LYM176 12381. 3 D 6.67 2.52E- 04 53.7 LYM254 1247 3.1 H 0.06 1.84E- 02 28.6 LYM149 12344. 2 D 7.18 2 2.74E- 04 65.5 LYM290 1250 4.1 H 0.06 5 2.04E- 02 39.9 LYM174 12412. 1 D 6.75 1 3.53E- 04 55.6 LYM89 1221 4.3 H 0.06 1 3.34E- 02 30.8 LYM170 12454. 2 D 6.62 6 3.98E- 04 52.7 LYM172 1230 1.2 H 0.05 7 3.68E- 02 22.3 LYM174 12411. 3 D 6.49 7 3.90E- 03 49.7 LYM42 1199 3.1 H 0.05 8 3.99E- 02 24.2 LYM289 12493. 2 D 6.46 9 8.75E- 03 49.1 LYM89 1221 4.4 H 0.05 7 4.67E- 02 22.5 LYM162 12234. 4 D 6.25 3 1.01E- 02 44.1 LYM148 1217 3.5 H 0.06 2 4.81E- 02 33.2 LYM105 12293. 1 D 5.67 1.26E- 02 30.7 LYM140 1226 1.2 H 0.05 6 5.27E- 02 19.9 LYM172 12301. 3 D 7.41 2 1.63E- 02 70.8 LYM236 1259 2.4 H 0.06 1 6.49E- 02 30.4 LYM172 12301. 2 D 7.67 4 1.83E- 02 76.9 LYM250 1261 4.1 H 0.05 5 9.32E- 02 19.6 LYM153 12321. 2 D 8.90 1 1.85E- 02 105.2 LYM176 1238 1.3 H 0.05 6 9.61E- 02 20.1 LYM153 12322. D 7.58 2.24E- 74.7 LYM290 1250 H 0.06 9.74E- 35.7 2016213786 11 Aug 2016 367 Gene name Event I D Mea n P value % incr. vs. cent. Gene name Event I D Mea n P value % incr. vs. cent. 1 02 1.3 3 02 LYM148 12174. 1 D 6.39 2.38E- 02 47.3 CONTR OL H 0.04 6 0 LYM254 12474. 4 D 5.37 7 2.95E- 02 23.9 LYM90 1239 2.1 A 0.00 5 1.00E- 06 108.9 LYM111 12254. 3 D 6.64 2 3.13E- 02 53.1 LYM213 1284 2.9 A 0.00 4 5.60E- 05 48.5 LYM170 12452. 4 D 5.43 8 5.31E- 02 25.3 LYM107 1263 3.4 A 0.00 6 1.12E- 04 153.5 LYM148 12171. 2 D 6.00 8 5.50E- 02 38.5 LYM157 1334 1.1 A 0.00 6 1.62E- 03 130.7 LYM174 12411. 2 D 6.70 3 6.07E- 02 54.5 LYM90 1239 4.2 A 0.00 5 2.24E- 03 78.2 LYM162 12231. 2 D 5.94 8 7.11E- 02 37.1 LYM107 1263 1.4 A 0.00 5 9.45E- 03 104 LYM162 12234. 3 D 6.31 9 8.38E- 02 45.6 LYM180 1344 1.7 A 0.00 4 1.15E- 02 58.4 LYM172 12304. 1 D 5.12 6 9.20E- 02 18.2 LYM90 1239 5.3 A 0.00 5 1.27E- 02 115.8 CONTR OL D 4.33 9 0 LYM248 1350 1.6 A 0.00 4 1.40E- 02 74.3 LYM176 12381. 3 E 0.57 2.35E- 02 42.8 LYM52 1289 5.7 A 0.00 5 1.64E- 02 87.1 LYM172 12301. 2 E 0.56 3 3.24E- 02 41.1 LYM52 1289 4.6 A 0.00 5 2.41E- 02 93.1 LYM174 12412. 1 E 0.56 3.53E- 02 40.3 LYM213 1284 1.8 A 0.00 7 2.71E- 02 161.4 LYM153 12322. 1 E 0.54 7 5.02E- 02 37.1 LYM68 1194 2.2 A 0.00 4 3.03E- 02 77.2 LYM254 12474. 4 E 0.54 5 5.08E- 02 36.5 LYM157 1334 1.3 A 0.00 7 3.06E- 02 193.1 LYM111 12254. 3 E 0.54 2 6.45E- 02 35.8 LYM180 1344 1.5 A 0.00 3 3.17E- 02 20.8 LYM170 12454. 2 E 0.53 7 6.57E- 02 34.5 LYM52 1289 1.8 A 0.00 7 3.60E- 02 183.2 LYM172 12301. 3 E 0.54 3 6.79E- 02 36.1 LYM68 1194 3.5 A 0.00 4 3.69E- 02 46.5 LYM148 12174. 1 E 0.53 5 6.85E- 02 34 LYM213 1284 1.6 A 0.00 8 3.70E- 02 235.6 LYM152 12376. 1 E 0.54 3 7.05E- 02 36.1 LYM117 1362 2.6 A 0.00 5 4.17E- 02 85.1 LYM174 12411. 2 E 0.53 5 7.56E- 02 34.1 LYM117 1362 1.8 A 0.00 4 4.82E- 02 57.4 LYM153 12321. 2 E 0.54 3 7.70E- 02 36.1 LYM52 1289 4.8 A 0.00 8 5.80E- 02 217.8 LYM170 12452. 3 E 0.53 8.57E- 02 32.8 LYM68 1194 1.3 A 0.00 4 5.93E- 02 41.6 LYM148 12171. 2 E 0.52 3 9.20E- 02 31.1 LYM248 1350 2.7 A 0.00 4 6.41E- 02 65.3 CONTR OL E 0.39 9 0 LYM117 1362 4.4 A 0.00 4 7.16E- 02 72.3 LYM149 12344. 2 F 6.80 1 1.57E- 03 33.2 LYM52 1289 4.7 A 0.00 6 7.32E- 02 152.5 2016213786 11 Aug 2016 368 Gene name Event I D Mea n P value % incr. vs. cent. Gene name Event I D Mea n P value % incr. vs. cent. LYM152 12376. 1 F 7.02 3 1.62E- 03 37.5 LYM157 1334 1.4 A 0.00 5 7.51E- 02 106.9 LYM148 12171. 2 F 6.66 3 2.42E- 03 30.5 LYM213 1284 1.7 A 0.00 5 8.38E- 02 114.9 LYM254 12474. 4 F 6.67 1 2.45E- 03 30.7 LYM180 1344 3.7 A 0.00 3 8.44E- 02 28.7 LYM174 12412. 1 F 6.79 1 2.67E- 03 33 LYM180 1344 2.6 A 0.00 4 9.89E- 02 50.5 LYM170 12454. 2 F 6.64 1 2.92E- 03 30.1 CONTR OL A 0.00 3 0 LYM170 12452. 3 F 6.74 2 3.91E- 03 32 LYM90 1239 2.1 B 0.15 2 1.06E- 03 81.1 LYM172 12301. 3 F 6.70 6 5.41E- 03 31.3 LYM107 1263 1.4 B 0.13 6 2.69E- 03 61.9 LYM148 12174. 1 F 6.44 9 5.65E- 03 26.3 LYM90 1239 5.3 B 0.13 5 5.72E- 03 60.8 LYM153 12321. 2 F 6.67 8 5.68E- 03 30.8 LYM157 1334 1.1 B 0.14 6 1.69E- 02 73.9 LYM153 12322. 1 F 6.44 3 5.80E- 03 26.2 LYM213 1284 1.6 B 0.20 3 1.93E- 02 141.6 LYM176 12381. 3 F 6.44 2 5.82E- 03 26.2 LYM117 1362 1.8 B 0.10 5 2.79E- 02 24.6 LYM289 12493. 2 F 6.37 7.79E- 03 24.8 LYM107 1263 3.4 B 0.14 4 3.61E- 02 71.1 LYM172 12301. 2 F 6.40 1 8.13E- 03 25.4 LYM68 1194 2.2 B 0.11 1 4.71E- 02 31.8 LYM174 12414. 3 F 6.25 9 1.53E- 02 22.6 LYM52 1289 4.6 B 0.13 1 4.73E- 02 55.6 LYM174 12411. 2 F 6.33 8 1.62E- 02 24.1 LYM52 1289 4.8 B 0.18 4 4.84E- 02 118.7 LYM148 12173. 5 F 6.26 8 1.64E- 02 22.7 LYM157 1334 1.3 B 0.16 5 5.02E- 02 96.8 LYM140 12262. 3 F 6.2 1.65E- 02 21.4 LYM52 1289 4.7 B 0.16 4 5.10E- 02 94.7 LYM111 12254. 3 F 6.35 2 1.66E- 02 24.4 LYM52 1289 1.8 B 0.14 7 5.39E- 02 75.3 LYM176 12384. 1 F 6.08 7 2.67E- 02 19.2 LYM90 1239 4.2 B 0.11 5.40E- 02 30.6 LYM170 12453. 2 F 6.09 8 3.46E- 02 19.4 LYM52 1289 5.7 B 0.15 5.54E- 02 78.1 LYM111 12252. 2 F 6.02 9 3.90E- 02 18.1 LYM248 1350 2.7 B 0.12 6.58E- 02 43.3 LYM162 12234. 4 F 5.98 4.10E- 02 17.1 LYM213 1284 2.9 B 0.09 9 6.68E- 02 17.3 LYM153 12323. 2 F 6.03 5 4.13E- 02 18.2 LYM117 1362 2.6 B 0.13 6 6.92E- 02 61.7 LYM162 12234. 3 F 6.27 6 4.14E- 02 22.9 LYM213 1284 1.8 B 0.18 6 9.20E- 02 121.5 LYM170 12452. 4 F 5.96 4.49E- 02 16.7 CONTR OL B 0.08 4 0 LYM149 12343. 2 F 6.25 5 5.80E- 02 22.5 LYM107 1263 3.4 C 0.99 1 0.00E +00 94.3 LYM162 12231. F 6.01 6.32E- 17.9 LYM107 1263 C 0.94 0.00E 85.1 2016213786 11 Aug 2016 369 Gene name Event I D Mea n P value % incr. vs. cent. Gene name Event I D Mea n P value % incr. vs. cent. 2 9 02 1.4 4 +00 LYM152 12373. 2 F 5.84 6 7.37E- 02 14.5 LYM52 1289 4.6 C 1.01 2 0.00E +00 98.3 LYM289 12493. 6 F 5.78 7 9.53E- 02 13.3 LYM52 1289 1.8 c 0.92 8 0.00E +00 81.9 CONTR OL F 5.10 6 0 LYM68 1194 2.2 c 0.98 0.00E +00 92.1 LYM152 12376. 1 G 0.99 3 4.96E- 04 50.8 LYM52 1289 4.8 c 0.95 4 1.00E- 06 87 LYM153 12321. 2 G 1.04 8 4.01E- 03 59.2 LYM213 1284 1.6 c 0.87 3.00E- 06 70.5 LYM148 12174. 1 G 0.91 6 6.30E- 03 39.2 LYM90 1239 2.1 c 0.86 9 1.10E- 05 70.4 LYM290 12502. 4 G 0.79 9 4.73E- 02 21.3 LYM157 1334 1.3 c 0.93 6 3.10E- 05 83.5 LYM172 12301. 2 G 0.86 2 5.63E- 02 30.9 LYM157 1334 1.1 c 0.82 3 1.04E- 04 61.3 LYM140 12262. 2 G 0.81 4 8.61E- 02 23.6 LYM90 1239 5.3 c 0.82 1.17E- 04 60.6 LYM174 12411. 3 G 0.86 7 9.28E- 02 31.7 LYM157 1334 1.4 c 0.81 2 1.51E- 04 59.2 CONTR OL G 0.65 8 0 LYM90 1239 4.2 c 0.77 9 2.54E- 04 52.8 LYM152 12376. 1 H 0.10 3 1.39E- 04 65.4 LYM68 1194 1.4 c 0.78 8 3.36E- 04 54.5 LYM153 12321. 2 H 0.10 6 2.48E- 04 69.7 LYM248 1350 1.6 c 0.78 4 5.63E- 04 53.7 LYM172 12301. 2 H 0.08 8 1.64E- 02 41 LYM107 1263 1.1 c 0.76 4 6.45E- 04 49.7 LYM148 12174. 1 H 0.08 6 1.81E- 02 38.1 LYM117 1362 2.6 c 0.74 1.38E- 03 45.1 LYM174 12411. 3 H 0.08 5 4.51E- 02 36.4 LYM52 1289 5.7 c 0.72 4 2.87E- 03 42 CONTR OL H 0.06 3 0 LYM52 1289 4.7 c 0.74 1 3.13E- 03 45.2 LYM175 12651. 2 A 0.00 5 1.27E- 03 85.3 LYM90 1239 3.1 c 0.72 8 8.19E- 03 42.6 LYM107 12632. 1 A 0.00 5 7.98E- 03 96.3 LYM157 1334 2.4 c 0.71 1.13E- 02 39.2 LYM203 12663. 2 A 0.00 6 1.07E- 02 104.6 LYM107 1263 1.2 c 0.67 1 2.27E- 02 31.6 LYM128 12642. 1 A 0.00 4 3.17E- 02 53.2 LYM213 1284 1.7 c 0.68 2.56E- 02 33.4 LYM128 12641. 3 A 0.00 4 5.95E- 02 64.2 LYM68 1194 2.3 c 0.67 9 3.65E- 02 33 LYM175 12654. 4 A 0.00 4 7.53E- 02 47.7 LYM90 1239 5.1 c 0.67 6 5.36E- 02 32.6 CONTR OL A 0.00 3 0 LYM68 1194 1.3 c 0.64 4 5.48E- 02 26.2 LYM107 12631. 1 B 0.09 2 9.39E- 03 28.3 LYM248 1350 3.5 c 0.64 7 6.20E- 02 26.8 LYM175 12654. 4 B 0.11 2 1.18E- 02 55.8 LYM117 1362 1.8 c 0.64 7 6.25E- 02 26.8 2016213786 11 Aug 2016 370 Gene name Event I D Mea n P value % incr. vs. cent. Gene name Event I D Mea n P value % incr. vs. cent. LYM203 12663. 2 B 0.12 2 1.66E- 02 69.5 LYM117 1362 4.7 C 0.63 6 7.06E- 02 24.6 LYM107 12632. 1 B 0.12 5 2.43E- 02 73.7 LYM117 1362 3.9 c 0.62 9 9.82E- 02 23.2 LYM175 12651. 2 B 0.11 7 2.91E- 02 62.4 CONTR OL c 0.51 0 LYM128 12642. 1 B 0.09 6 3.18E- 02 33.2 LYM213 1284 1.6 D 7.63 8 4.50E- 05 69.8 LYM128 12641. 3 B 0.09 6 6.27E- 02 33.4 LYM117 1362 2.6 D 6.21 9 9.60E- 05 38.3 LYM203 12662. 2 B 0.15 7.88E- 02 108.2 LYM107 1263 1.2 D 5.85 2 3.86E- 04 30.1 CONTR OL B 0.07 2 0 LYM68 1194 2.2 D 8.37 1 4.18E- 04 86.1 LYM128 12642. 1 C 0.59 4.98E- 04 67 LYM52 1289 1.8 D 8.04 8 4.29E- 04 78.9 LYM203 12663. 2 C 0.49 6 2.37E- 02 40.5 LYM90 1239 4.2 D 6.75 1 1.42E- 03 50.1 LYM203 12662. 2 C 0.52 9 5.42E- 02 49.7 LYM107 1263 1.1 D 6.53 1 2.91E- 03 45.2 LYM128 12641. 3 C 0.44 7 7.46E- 02 26.7 LYM52 1289 5.7 D 6.18 3 5.76E- 03 37.5 LYM107 12631. 2 C 0.48 2 8.17E- 02 36.6 LYM52 1289 4.6 D 8.57 2 6.41E- 03 90.6 CONTR OL C 0.35 3 0 LYM107 1263 1.4 D 8.24 9 7.31E- 03 83.4 LYM128 12642. 1 D 5.09 8 4.34E- 03 62 LYM90 1239 2.1 D 7.58 6 1.12E- 02 68.6 LYM128 12641. 3 D 4.17 6 1.25E- 02 32.7 LYM52 1289 4.8 D 8.22 8 1.31E-02 82.9 LYM203 12663. 2 D 4.26 6 7.47E- 02 35.6 LYM107 1263 3.4 D 8.64 4 1.42E- 02 92.2 CONTR OL D 3.14 6 0 LYM90 1239 5.3 D 7.12 1.67E- 02 58.3 LYM128 12641. 3 E 0.44 7 9.19E- 04 33 LYM157 1334 1.4 D 7.11 4 1.98E- 02 58.2 LYM128 12641. 5 E 0.43 3 3.42E- 03 28.7 LYM68 1194 1.4 D 6.66 3 2.04E- 02 48.1 LYM128 12642. 1 E 0.44 4.86E- 03 30.8 LYM117 1362 4.7 D 5.48 2 2.19E- 02 21.9 LYM203 12663. 2 E 0.41 3 2.97E- 02 22.8 LYM68 1194 1.3 D 5.57 8 2.27E- 02 24 LYM203 12662. 2 E 0.40 4 3.66E- 02 20.3 LYM157 1334 1.1 D 7.02 6 2.67E- 02 56.2 LYM128 12641. 1 E 0.41 4 8.08E- 02 23.3 LYM248 1350 1.6 D 6.80 9 3.00E- 02 51.4 CONTR OL E 0.33 6 0 LYM117 1362 1.8 D 5.70 3 4.86E- 02 26.8 LYM128 12642. 1 F 6.01 2 8.60E- 05 45.8 LYM52 1289 4.7 D 6.31 4 5.92E- 02 40.4 LYM128 12641. 3 F 5.47 9 1.32E- 04 32.9 LYM157 1334 1.3 D 8.09 2 7.45E- 02 79.9 LYM203 12663. F 5.07 7.26E- 23 LYM213 1284 D 6.06 8.34E- 34.8 2016213786 11 Aug 2016 371 Gene name Event I D Mea n P value % incr. vs. cent. Gene name Event I D Mea n P value % incr. vs. cent. 2 03 1.7 2 02 LYM203 12664. 1 F 4.69 9 7.69E- 03 14 LYM180 1344 3.7 D 5.25 9 8.41E- 02 16.9 LYM203 12662. 2 F 5.04 1 1.20E- 02 22.3 LYM157 1334 2.4 D 6.14 3 8.49E- 02 36.6 LYM128 12641. 5 F 4.68 6 1.21E- 02 13.7 CONTR OL D 4.49 8 0 LYM175 12651. 4 F 4.80 2 1.96E- 02 16.5 LYM68 1194 1.4 E 0.61 6 1.55E- 03 41.7 LYM107 12632. 3 F 4.57 3 3.01E- 02 10.9 LYM107 1263 1.1 E 0.59 8 3.20E- 03 37.5 LYM107 12631. 2 F 5.32 5 7.35E- 02 29.1 LYM68 1194 2.2 E 0.59 3 4.66E- 03 36.4 LYM128 12641. 1 F 5.15 1 7.83E- 02 24.9 LYM52 1289 4.6 E 0.59 6 4.93E- 03 37.2 CONTR OL F 4.12 3 0 LYM248 1350 3.5 E 0.58 8 5.03E- 03 35.2 LYM107 12632. 1 G 0.52 5 1.77E- 03 All LYM90 1239 3.1 E 0.58 7 5.49E- 03 34.9 LYM128 12642. 1 G 0.56 8 2.05E- 03 59.3 LYM52 1289 5.7 E 0.58 6 5.79E- 03 34.7 LYM128 12641. 3 G 0.51 9 4.67E- 03 45.3 LYM68 1194 1.3 E 0.58 6 6.68E- 03 34.7 LYM203 12663. 2 G 0.58 3 1.40E- 02 63.4 LYM52 1289 4.8 E 0.57 9 9.24E- 03 33.1 LYM107 12631. 1 G 0.44 7 4.06E- 02 25.4 LYM90 1239 4.2 E 0.56 9 1.49E- 02 30.9 LYM175 12651. 2 G 0.56 8 5.89E- 02 59.1 LYM157 1334 1.3 E 0.55 4 2.88E- 02 27.3 LYM203 12662. 2 G 0.60 9 5.96E- 02 70.7 LYM213 1284 1.6 E 0.55 3 2.96E- 02 27.1 CONTR OL G 0.35 7 0 LYM248 1350 1.6 E 0.55 8 3.17E- 02 28.3 LYM128 12642. 1 H 0.05 7 4.93E- 03 57.5 LYM107 1263 3.4 E 0.54 6 4.23E- 02 25.5 LYM203 12663. 2 H 0.05 6 9.28E- 03 55.3 LYM157 1334 1.1 E 0.54 5 4.29E- 02 25.2 LYM203 12662. 2 H 0.06 1.20E- 02 65 LYM180 1344 1.7 E 0.54 1 5.32E- 02 24.4 LYM128 12641. 3 H 0.05 1 2.49E- 02 40.3 LYM157 1334 1.4 E 0.54 5.93E- 02 24.2 LYM175 12651. 2 H 0.05 6 2.52E- 02 55.8 LYM107 1263 1.2 E 0.53 9 6.08E- 02 24 LYM107 12632. 1 H 0.05 1 2.94E- 02 40.3 LYM90 1239 2.1 E 0.53 3 8.04E- 02 22.5 CONTR OL H 0.03 6 0 LYM68 1194 2.3 E 0.52 6 9.63E- 02 20.9 LYM224 13435. 3 A 0.00 7 0.00E +00 90.7 CONTR OL E 0.43 5 0 LYM217 13182. 1 A 0.00 9 9.40E- 05 160 LYM107 1263 3.4 F 7.25 1 0.00E +00 30.4 LYM23 12783. 5 A 0.00 7 6.40E- 04 99 LYM68 1194 2.2 F 7.60 7 0.00E +00 36.8 2016213786 11 Aug 2016 372 Gene name Event I D Mea n P value % incr. vs. cent. Gene name Event I D Mea n P value % incr. vs. cent. LYM164 12813. 5 A 0.01 1.20E- 03 169 LYM90 1239 3.1 F 7.20 6 0.00E +00 29.6 LYM164 12813. 8 A 0.00 9 2.03E- 03 143.6 LYM52 1289 4.8 F 6.93 2 3.00E- 06 24.7 LYM251 13073. 8 A 0.00 7 3.58E- 03 84.6 LYM157 1334 1.3 F 6.85 4 1.40E- 05 23.3 LYM122 13712. 3 A 0.00 5 3.83E- 03 45.5 LYM90 1239 4.2 F 6.94 1 1.40E- 05 24.9 LYM274 13414. 2 A 0.00 9 4.46E- 03 138.1 LYM68 1194 1.3 F 7.08 2 7.00E- 05 27.4 LYM217 13181. 11 A 0.00 9 4.68E- 03 136.7 LYM180 1344 1.5 F 6.59 6 8.70E- 05 18.6 LYM79 13132. 2 A 0.01 6.39E- 03 166.9 LYM157 1334 1.4 F 6.80 5 1.05E- 04 22.4 LYM273 13721. 3 A 0.01 1 7.17E- 03 201.2 LYM248 1350 3.5 F 7.13 1.31E-04 28.3 LYM273 13721. 1 A 0.00 7 8.18E- 03 81.8 LYM52 1289 5.7 F 6.93 6 2.60E- 04 24.8 LYM249 13631. 1 A 0.00 6 8.20E- 03 64.7 LYM90 1239 5.3 F 6.74 7 7.99E- 04 21.4 LYM23 12783. 7 A 0.01 8.56E- 03 162.1 LYM107 1263 1.1 F 6.89 9.89E- 04 23.9 LYM122 13713. 2 A 0.00 7 8.63E- 03 80.4 LYM180 1344 3.7 F 6.93 4 1.01E- 03 24.7 LYM249 13633. 1 A 0.01 9.46E- 03 172.4 LYM52 1289 1.8 F 6.48 6 1.57E- 03 16.7 LYM193 13484. 3 A 0.00 8 9.51E- 03 127.8 LYM248 1350 1.6 F 7.25 6 2.13E- 03 30.5 LYM245 13061. 6 A 0.00 7 1.45E- 02 82.5 LYM213 1284 1.6 F 6.73 6 3.86E- 03 21.2 LYM273 13722. 4 A 0.00 7 1.60E- 02 90.1 LYM157 1334 1.1 F 6.31 2 3.94E- 03 13.6 LYM251 13072. 8 A 0.00 9 1.70E- 02 138.1 LYM90 1239 5.1 F 6.79 6 4.94E- 03 22.2 LYM217 13181. 7 A 0.00 6 1.82E- 02 53 LYM107 1263 1.2 F 6.84 6 6.89E- 03 23.2 LYM23 12782. 6 A 0.00 8 2.17E- 02 114.8 LYM248 1350 2.7 F 6.67 3 6.91E- 03 20 LYM122 13714. 4 A 0.01 2.25E- 02 166.2 LYM157 1334 2.4 F 6.44 2 7.43E- 03 15.9 LYM245 13062. 5 A 0.00 8 2.38E- 02 131.2 LYM107 1263 1.4 F 6.95 9 8.62E- 03 25.2 LYM79 13133. 1 A 0.00 6 3.11E- 02 62.6 LYM52 1289 4.6 F 7.32 8 1.06E- 02 31.8 LYM23 12784. 6 A 0.00 7 4.14E- 02 95.5 LYM68 1194 1.4 F 6.93 7 1.08E- 02 24.8 LYM251 13073. 7 A 0.00 8 4.14E- 02 126.4 LYM68 1194 2.3 F 6.77 1 1.09E- 02 21.8 LYM273 13723. 1 A 0.00 8 4.80E- 02 123 LYM117 1362 1.8 F 6.43 1 1.47E- 02 15.7 LYM224 13434. 2 A 0.00 6 4.97E- 02 59.9 LYM180 1344 2.6 F 6.00 3 1.85E- 02 8 LYM251 13074. A 0.00 5.26E- 49.6 LYM213 1284 F 6.00 1.91E- 7.9 2016213786 11 Aug 2016 373 Gene name Event I D Mea n P value % incr. vs. cent. Gene name Event I D Mea n P value % incr. vs. cent. 6 5 02 2.8 1 02 LYM274 13413. 4 A 0.00 6 5.58E- 02 76.3 LYM180 1344 1.7 F 6.81 4 2.38E- 02 22.6 LYM273 13722. 3 A 0.00 7 6.00E- 02 80.4 LYM90 1239 2.1 F 6.51 8 3.57E- 02 17.2 LYM224 13435. 1 A 0.01 6.64E- 02 177.9 LYM52 1289 4.7 F 6.23 2 5.88E- 02 12.1 LYM217 13183. 2 A 0.00 9 6.68E- 02 156.6 LYM213 1284 1.7 F 6.42 9 9.76E- 02 15.6 LYM217 13181. 6 A 0.00 6 6.76E- 02 62.6 CONTR OL F 5.55 9 0 LYM79 13133. 3 A 0.00 5 6.76E- 02 41.3 LYM68 1194 2.2 G 0.71 9 1.00E- 06 54.5 LYM23 12783. 8 A 0.00 5 7.66E- 02 30.4 LYM90 1239 5.3 G 0.72 4 1.00E- 06 55.5 LYM122 13714. 2 A 0.00 8 7.70E- 02 114.8 LYM117 1362 3.9 G 0.58 6 5.20E- 05 25.8 LYM249 13631. 2 A 0.00 7 8.25E- 02 105.1 LYM248 1350 1.6 G 0.71 9 6.60E- 05 54.4 LYM274 13415. 2 A 0.00 7 8.30E- 02 83.2 LYM117 1362 2.6 G 0.70 9 5.32E- 04 52.2 LYM249 13631. 4 A 0.00 5 8.68E- 02 31.7 LYM107 1263 1.4 G 0.73 3 5.34E- 04 57.3 LYM251 13072. 6 A 0.00 9 9.27E- 02 159.3 LYM180 1344 1.7 G 0.66 4 1.17E- 03 42.6 LYM240 12682. 1 A 0.00 9 9.57E- 02 148.4 LYM52 1289 1.8 G 0.87 8 1.61E- 03 88.5 CONTR OL A 0.00 4 0 LYM213 1284 1.6 G 1.09 8 2.01E- 03 135.7 LYM251 13073. 8 B 0.14 5 7.17E- 04 59.3 LYM68 1194 3.5 G 0.65 3 2.34E- 03 40.2 LYM164 12813. 8 B 0.16 6 8.84E- 04 82.4 LYM117 1362 1.8 G 0.60 8 3.36E- 03 30.6 LYM122 13712. 3 B 0.12 2 8.94E- 04 33.4 LYM90 1239 4.2 G 0.64 4 3.68E- 03 38.4 LYM217 13182. 1 B 0.17 9 1.19E- 03 96.3 LYM52 1289 4.6 G 0.69 3.90E- 03 48.2 LYM273 13721. 3 B 0.22 1 1.26E- 03 142.7 LYM157 1334 1.1 G 0.80 4 3.92E- 03 72.7 LYM249 13631. 1 B 0.15 9 1.43E- 03 74.6 LYM107 1263 3.4 G 0.82 9 5.17E- 03 78 LYM273 13721. 1 B 0.13 2 1.54E- 03 44.4 LYM52 1289 5.7 G 0.78 6 1.65E- 02 68.8 LYM193 13484. 3 B 0.16 5 2.86E- 03 80.7 LYM52 1289 4.8 G 0.98 7 1.95E- 02 111.9 LYM79 13132. 2 B 0.2 3.59E- 03 119.3 LYM117 1362 4.7 G 0.59 2 2.59E- 02 27.2 LYM217 13181. 11 B 0.20 3 4.90E- 03 123.1 LYM213 1284 1.8 G 0.74 6 2.62E- 02 60.2 LYM122 13714. 4 B 0.24 9 4.98E- 03 172.7 LYM180 1344 1.5 G 0.63 2 2.70E- 02 35.7 LYM273 13723. 1 B 0.16 5 8.86E- 03 80.7 LYM117 1362 4.4 G 0.57 6 2.79E- 02 23.6 2016213786 11 Aug 2016 374 Gene name Event I D Mea n P value % incr. vs. cent. Gene name Event I D Mea n P value % incr. vs. cent. LYM274 13411. 2 B 0.11 4 1.00E- 02 24.9 LYM248 1350 2.7 G 0.68 5 2.84E- 02 47.1 LYM274 13414. 2 B 0.18 9 1.01E- 02 107.4 LYM107 1263 2.1 G 0.58 8 2.98E- 02 26.3 LYM249 13633. 1 B 0.19 5 1.09E- 02 114.2 LYM157 1334 1.4 G 0.88 2 3.13E- 02 89.4 LYM245 13062. 5 B 0.19 7 1.37E- 02 116.1 LYM68 1194 1.3 G 0.57 3 5.05E- 02 23 LYM274 13413. 4 B 0.14 1 1.41E- 02 54.1 LYM157 1334 1.3 G 0.83 4 5.09E- 02 79.2 LYM23 12783. 7 B 0.20 4 1.57E- 02 123.9 LYM107 1263 1.1 G 0.68 8 5.95E- 02 47.8 LYM224 13435. 3 B 0.14 9 2.06E- 02 63.9 LYM90 1239 2.1 G 0.63 3 6.01E- 02 35.9 LYM79 13134. 3 B 0.14 2.13E- 02 53.9 LYM157 1334 1.7 G 0.71 7 8.11E- 02 54 LYM251 13072. 8 B 0.16 1 2.19E- 02 76.5 LYM52 1289 4.7 G 0.72 9.20E- 02 54.6 LYM23 12783. 8 B 0.13 1 2.26E- 02 43.9 LYM213 1284 1.7 G 0.69 8 9.67E- 02 49.9 LYM164 12813. 5 B 0.22 1 2.28E- 02 142.7 CONTR OL G 0.46 6 0 LYM23 12782. 7 B 0.12 5 2.52E- 02 36.8 LYM107 1263 3.4 H 0.08 1 0.00E +00 83.3 LYM217 13181. 7 B 0.12 4 3.28E- 02 35.6 LYM107 1263 1.4 H 0.07 8 0.00E +00 75.7 LYM23 12782. 6 B 0.16 3.33E- 02 76 LYM117 1362 2.6 H 0.08 0.00E +00 79.3 LYM273 13722. 3 B 0.14 8 4.38E- 02 62.3 LYM157 1334 1.4 H 0.09 2 0.00E +00 108 LYM122 13712. 1 B 0.14 7 4.52E- 02 61.4 LYM157 1334 1.1 H 0.08 0.00E +00 80.9 LYM251 13072. 6 B 0.23 1 4.55E- 02 153.2 LYM213 1284 1.6 H 0.11 1 0.00E +00 149.2 LYM251 13074. 6 B 0.12 8 4.80E- 02 40.5 LYM52 1289 4.8 H 0.10 3 0.00E +00 131.6 LYM131 12791. 5 B 0.13 6 5.54E- 02 49.2 LYM52 1289 1.8 H 0.09 3 0.00E +00 108.9 LYM240 12682. 1 B 0.16 4 5.66E- 02 80.3 LYM52 1289 5.7 H 0.08 3 0.00E +00 87 LYM122 13713. 2 B 0.14 6 5.87E- 02 60.6 LYM90 1239 5.3 H 0.07 6 0.00E +00 71 LYM23 12784. 6 B 0.18 6.16E- 02 97.8 LYM68 1194 2.2 H 0.07 4 1.00E- 06 67.4 LYM79 13133. 3 B 0.13 1 6.29E- 02 43.3 LYM52 1289 4.6 H 0.07 5 2.00E- 06 68.1 LYM122 13714. 2 B 0.17 6 6.66E- 02 93.6 LYM157 1334 1.3 H 0.08 5 3.00E- 06 92.7 LYM249 13631. 2 B 0.17 2 6.94E- 02 88.8 LYM213 1284 1.8 H 0.07 4 1.70E- 05 66.3 LYM224 13435. 1 B 0.22 5 7.12E- 02 146.6 LYM248 1350 1.6 H 0.06 9 3.10E- 05 56.2 LYM217 13183. B 0.19 7.76E- 115.6 LYM90 1239 H 0.06 3.80E- 54.1 2016213786 11 Aug 2016 375 Gene name Event I D Mea n P value % incr. vs. cent. Gene name Event I D Mea n P value % incr. vs. cent. 2 1 02 4.2 8 05 LYM23 12783. 5 B 0.16 2 8.12E- 02 77.2 LYM107 1263 1.1 H 0.07 3 4.60E- 05 65.3 LYM217 13181. 6 B 0.14 5 8.35E- 02 59 LYM68 1194 3.5 H 0.06 9 6.60E- 05 54.6 LYM40 13732. 1 B 0.14 3 8.41E- 02 56.4 LYM52 1289 4.7 H 0.07 4 1.57E- 04 66.8 LYM79 13133. 1 B 0.15 6 9.62E- 02 70.9 LYM90 1239 2.1 H 0.06 8 2.75E- 04 52.6 LYM273 13722. 4 B 0.14 9.64E- 02 54 LYM213 1284 1.7 H 0.07 5.36E- 04 58.5 CONTR OL B 0.09 1 0 LYM157 1334 1.7 H 0.07 7.79E- 04 57.3 LYM122 13714. 4 C 0.90 5 0.00E +00 135.4 LYM117 1362 4.7 H 0.06 2 2.19E- 03 39.2 LYM122 13713. 2 C 0.68 1 0.00E +00 77 LYM117 1362 4.4 H 0.06 4.46E- 03 35.7 LYM131 12793. 3 C 0.66 3 0.00E +00 72.4 LYM248 1350 2.7 H 0.06 3 4.46E- 03 41 LYM164 12813. 5 C 0.93 3 0.00E +00 142.7 LYM180 1344 1.7 H 0.06 4.78E- 03 35 LYM193 13482. 4 C 0.74 5 0.00E +00 93.9 LYM117 1362 3.9 H 0.05 9 7.75E- 03 31.9 LYM217 13181. 6 C 0.85 9 0.00E +00 123.4 LYM68 1194 1.4 H 0.06 9.46E- 03 36.1 LYM23 12783. 7 C 0.78 0.00E +00 102.9 LYM180 1344 1.5 H 0.05 8 1.89E- 02 30.4 LYM245 13062. 5 C 0.77 3 0.00E +00 101.1 LYM107 1263 2.1 H 0.05 7 1.94E- 02 29.2 LYM245 13061. 6 C 0.64 6 0.00E +00 68 LYM90 1239 3.1 H 0.06 2.02E- 02 36.1 LYM249 13631. 2 C 0.88 6 0.00E +00 130.4 LYM68 1194 1.3 H 0.05 7 2.16E- 02 29.1 LYM249 13633. 1 C 0.84 4 0.00E +00 119.6 LYM157 1334 2.4 H 0.05 9 2.17E- 02 33.1 LYM251 13073. 8 C 1.06 0.00E +00 175.7 LYM68 1194 2.3 H 0.06 3 2.18E- 02 42.3 LYM251 13073. 7 C 0.91 8 0.00E +00 138.9 LYM180 1344 2.6 H 0.05 7 3.88E- 02 27.7 LYM251 13072. 6 C 0.77 7 0.00E +00 102.2 LYM117 1362 1.8 H 0.05 5 5.30E- 02 24.2 LYM251 13072. 8 C 0.77 0.00E +00 100.4 CONTR OL H 0.04 4 0 LYM251 13074. 6 C 0.75 5 0.00E +00 96.5 LYM268 1248 2.3 A 0.00 4 6.00E- 06 66.2 LYM273 13723. 1 C 0.88 6 0.00E +00 130.5 LYM140 1226 1.2 A 0.00 4 5.80E- 05 59.4 LYM273 13721. 3 C 0.75 5 0.00E +00 96.3 LYM162 1223 1.3 A 0.00 6 7.40E- 05 130.9 LYM273 13722. 4 C 0.66 5 0.00E +00 73 LYM13 1177 4.1 A 0.00 6 1.23E- 04 132.9 LYM274 13414. 2 C 0.85 5 0.00E +00 122.3 LYM140 1226 1.1 A 0.00 5 2.00E- 04 74.9 2016213786 11 Aug 2016 376 Gene name Event I D Mea n P value % incr. vs. cent. Gene name Event I D Mea n P value % incr. vs. cent. LYM274 13415. 2 C 0.84 7 0.00E +00 120.2 LYM134 1231 4.2 A 0.00 4 3.70E- 04 68.1 LYM274 13413. 4 c 0.82 4 0.00E +00 114.4 LYM162 1223 4.3 A 0.00 8 7.16E- 04 204.3 LYM40 13734. 2 c 0.61 1 0.00E +00 58.9 LYM132 1227 1.4 A 0.00 5 8.37E- 04 79.7 LYM79 13132. 2 c 0.81 1 0.00E +00 110.9 LYM140 1226 1.4 A 0.00 4 1.14E- 03 47.8 LYM79 13133. 1 c 0.71 0.00E +00 84.6 LYM289 1249 1.1 A 0.00 5 1.21E- 03 110.6 LYM79 13134. 3 c 0.63 8 0.00E +00 66 LYM290 1250 4.1 A 0.00 4 2.88E- 03 49.8 LYM249 13631. 4 c 0.59 4 1.00E- 06 54.4 LYM290 1250 2.4 A 0.00 5 3.71E- 03 101.9 LYM122 13712. 3 c 0.62 4 2.00E- 06 62.3 LYM113 1244 4.4 A 0.00 5 3.73E- 03 104.8 LYM273 13722. 3 c 0.65 2.00E- 06 69.2 LYM140 1226 2.2 A 0.00 7 4.11E- 03 187.9 LYM23 12784. 6 c 0.62 5 3.00E- 06 62.5 LYM134 1231 2.4 A 0.00 6 5.01E- 03 122.2 LYM224 13435. 1 c 0.69 1 4.00E- 06 79.7 LYM268 1248 3.4 A 0.00 6 5.96E- 03 150.2 LYM249 13631. 1 c 0.57 4 7.00E- 06 49.3 LYM132 1227 5.3 A 0.00 5 7.41E- 03 73.9 LYM40 13732. 1 c 0.72 8 1.00E- 05 89.4 LYM268 1248 2.1 A 0.00 9 1.25E- 02 246.9 LYM79 13133. 3 c 0.58 9 1.50E- 05 53.1 LYM102 1222 2.3 A 0.01 3 1.32E- 02 387.9 LYM240 12682. 1 c 0.89 8 1.80E- 05 133.5 LYM3 1204 1.2 A 0.00 5 1.33E- 02 107.7 LYM131 12791. 8 c 0.73 4 3.10E- 05 90.9 LYM289 1249 3.2 A 0.00 6 1.44E- 02 144.4 LYM274 13413. 1 c 0.61 7 4.50E- 05 60.5 LYM3 1204 2.1 A 0.00 5 1.46E- 02 108.7 LYM260 13095. 7 c 0.58 6 7.10E- 05 52.5 LYM162 1223 4.4 A 0.00 5 1.69E- 02 101 LYM23 12782. 6 c 0.63 5 8.80E- 05 65.2 LYM113 1244 4.5 A 0.00 5 1.98E- 02 96.1 LYM40 13732. 2 c 0.57 1.08E- 04 48.4 LYM113 1244 2.2 A 0.00 5 2.39E- 02 95.2 LYM260 13095. 1 c 0.76 9 1.25E- 04 100 LYM289 1249 2.2 A 0.00 8 2.43E- 02 194.7 LYM122 13712. 1 c 0.59 4 1.35E- 04 54.4 LYM106 1214 2.1 A 0.00 9 2.45E- 02 261.4 LYM164 12814. 8 c 0.56 5 2.55E- 04 47 LYM113 1244 2.1 A 0.00 6 2.58E- 02 136.7 LYM245 13064. 8 c 0.57 9 3.35E- 04 50.6 LYM132 1227 3.2 A 0.00 3 2.75E- 02 25.6 LYM122 13714. 2 c 0.61 8 3.64E- 04 60.6 LYM134 1231 2.3 A 0.00 7 2.91E- 02 155.1 LYM164 12814. 7 c 0.56 8 5.97E- 04 47.6 LYM148 1217 3.1 A 0.00 6 2.96E- 02 130 LYM224 13434. c 0.54 8.91E- 41.8 LYM13 1177 A 0.00 2.97E- 36.2 2016213786 11 Aug 2016 377 Gene name Event I D Mea n P value % incr. vs. cent. Gene name Event I D Mea n P value % incr. vs. cent. 2 5 04 2.2 4 02 LYM164 12813. 8 C 0.53 4 9.49E- 04 38.8 LYM132 1227 6.1 A 0.00 8 3.01E- 02 206.3 LYM224 13435. 5 c 0.55 4 1.23E- 03 44 LYM129 1257 3.1 A 0.00 4 3.03E- 02 71 LYM193 13484. 4 c 0.53 1 1.25E- 03 38 LYM102 1222 2.1 A 0.01 2 3.89E- 02 345.4 LYM23 12783. 8 c 0.51 5 1.59E- 03 33.9 LYM134 1231 1.2 A 0.00 6 4.57E- 02 122.2 LYM193 13484. 3 c 0.53 7 2.28E- 03 39.7 LYM268 1248 1.1 A 0.00 4 5.25E- 02 72.9 LYM217 13182. 1 c 0.54 4 3.30E- 03 41.4 LYM10 1174 4.5 A 0.00 4 5.94E- 02 47.8 LYM249 13631. 3 c 0.49 4 5.23E- 03 28.5 LYM148 1217 2.1 A 0.00 6 6.12E- 02 116.4 LYM79 13134. 2 c 0.50 4 8.40E- 03 31.1 LYM113 1244 3.1 A 0.00 8 6.54E- 02 197.6 LYM273 13721. 1 c 0.50 5 1.06E- 02 31.4 LYM289 1249 1.4 A 0.00 4 6.60E- 02 52.7 LYM260 13095. 8 c 0.49 7 1.36E- 02 29.2 LYM102 1222 2.2 A 0.00 8 7.00E- 02 222.7 LYM23 12782. 7 c 0.50 3 1.53E- 02 30.9 LYM10 1174 2.2 A 0.00 4 8.72E- 02 44 LYM245 13061. 8 c 0.48 3 1.73E- 02 25.7 LYM13 1177 2.1 A 0.00 5 9.00E- 02 77.8 LYM23 12783. 5 c 0.48 7 1.88E- 02 26.7 LYM129 1257 3.5 A 0.00 5 9.06E- 02 85.5 LYM217 13181. 7 c 0.47 9 3.48E- 02 24.7 LYM102 1222 1.1 A 0.00 7 9.14E- 02 183.1 LYM224 13432. 1 c 0.46 5 3.71E- 02 21 LYM106 1214 4.4 A 0.00 4 9.31E- 02 66.2 CONTR OL c 0.38 4 0 LYM3 1204 3.2 A 0.00 4 9.69E- 02 70 LYM122 13713. 2 D 6.38 8 0.00E +00 77 CONTR OL A 0.00 3 0 LYM249 13631. 4 D 5.39 8 0.00E +00 49.6 LYM13 1177 4.1 B 0.13 2 3.00E- 06 64.6 LYM273 13723. 1 D 7.90 7 0.00E +00 119.1 LYM3 1204 1.2 B 0.13 4 2.20E- 04 66.7 LYM249 13631. 3 D 4.59 9 3.10E- 05 27.4 LYM162 1223 4.3 B 0.18 6 4.15E- 04 131.8 LYM249 13631. 1 D 5.21 5 4.80E- 05 44.5 LYM162 1223 4.4 B 0.12 6.94E- 04 49.1 LYM251 13073. 8 D 9.27 6 2.48E- 04 157 LYM140 1226 1.2 B 0.10 3 8.53E- 04 28 LYM131 12793. 3 D 5.81 7 2.93E- 04 61.2 LYM3 1204 3.2 B 0.10 4 3.07E- 03 29.9 LYM164 12813. 5 D 8.33 4 4.25E- 04 130.9 LYM290 1250 2.4 B 0.13 3.23E- 03 61.6 LYM245 13061. 6 D 6.16 3 1.03E- 03 70.8 LYM132 1227 6.1 B 0.15 9 3.74E- 03 98.1 LYM273 13722. 4 D 5.99 7 1.03E- 03 66.2 LYM162 1223 1.3 B 0.13 6 5.97E- 03 69.7 2016213786 11 Aug 2016 378 Gene name Event I D Mea n P value % incr. vs. cent. Gene name Event I D Mea n P value % incr. vs. cent. LYM23 12783. 8 D 4.63 1 2.39E- 03 28.3 LYM134 1231 2.3 B 0.15 7 6.63E- 03 95.2 LYM40 13734. 2 D 5.44 6 2.86E- 03 50.9 LYM289 1249 1.1 B 0.12 8 7.98E- 03 59 LYM217 13181. 6 D 7.55 6 3.51E- 03 109.4 LYM140 1226 2.2 B 0.17 4 8.75E- 03 117.3 LYM224 13432. 1 D 4.16 5 4.08E- 03 15.4 LYM132 1227 5.3 B 0.11 4 8.82E- 03 41.5 LYM274 13415. 2 D 7.41 9 4.10E- 03 105.6 LYM289 1249 2.2 B 0.19 1.16E- 02 137.4 LYM251 13074. 6 D 6.66 6 4.94E- 03 84.7 LYM268 1248 2.1 B 0.19 2 1.21E- 02 139.2 LYM249 13633. 1 D 8 4.95E- 03 121.7 LYM113 1244 2.1 B 0.14 5 1.30E- 02 80.3 LYM23 12783. 7 D 7.13 7 6.65E- 03 97.7 LYM268 1248 3.4 B 0.13 2 1.32E- 02 64.2 LYM79 13134. 3 D 5.54 7.39E- 03 53.5 LYM3 1204 2.1 B 0.14 2 1.38E- 02 77.1 LYM122 13714. 4 D 8.31 5 8.23E- 03 130.4 LYM290 1250 4.1 B 0.09 5 1.49E- 02 17.8 LYM79 13133. 1 D 6.17 9 1.22E- 02 71.2 LYM148 1217 3.1 B 0.14 1 1.51E- 02 75.8 LYM79 13132. 2 D 7.31 5 1.42E- 02 102.7 LYM134 1231 2.4 B 0.13 9 1.55E- 02 73.1 LYM251 13072. 6 D 7.17 5 1.42E- 02 98.8 LYM290 1250 2.1 B 0.09 6 1.59E- 02 20 LYM251 13073. 7 D 8.23 1.56E- 02 128 LYM106 1214 4.4 B 0.10 3 1.67E- 02 28.3 LYM251 13072. 8 D 6.89 6 1.59E- 02 91.1 LYM102 1222 2.3 B 0.25 2 2.42E- 02 213.8 LYM273 13721. 3 D 6.84 4 1.74E- 02 89.6 LYM148 1217 2.1 B 0.12 7 2.50E- 02 58.1 LYM274 13414. 2 D 7.66 7 1.85E- 02 112.4 LYM106 1214 2.1 B 0.19 4 2.73E- 02 141.6 LYM245 13062. 5 D 6.54 3 2.21E- 02 81.3 LYM102 1222 2.1 B 0.23 7 3.04E- 02 195.1 LYM40 13732. 2 D 5.37 3 2.26E- 02 48.9 LYM113 1244 4.5 B 0.13 3 3.89E- 02 65.3 LYM122 13712. 3 D 5.38 4 2.45E- 02 49.2 LYM129 1257 3.5 B 0.13 5 3.90E- 02 67.9 LYM224 13435. 1 D 6.55 4 2.96E- 02 81.6 LYM129 1257 1.3 B 0.15 1 4.13E- 02 88.4 LYM249 13631. 2 D 7.72 3.46E- 02 113.9 LYM268 1248 2.3 B 0.09 4 4.38E- 02 17.1 LYM273 13722. 3 D 5.77 7 3.61E- 02 60.1 LYM113 1244 4.4 B 0.13 6 4.55E- 02 69.1 LYM79 13133. 3 D 5.12 6 3.67E- 02 42 LYM289 1249 3.2 B 0.13 4.69E- 02 62.4 LYM23 12784. 6 D 5.42 8 3.91E- 02 50.4 LYM113 1244 3.1 B 0.18 6 5.16E- 02 131.8 LYM193 13482. 4 D 6.65 4 4.51E- 02 84.4 LYM134 1231 1.2 B 0.13 9 5.91E- 02 73.4 LYM193 13484. D 4.89 4.61E- 35.6 LYM132 1227 B 0.10 6.45E- 31.3 2016213786 11 Aug 2016 379 Gene name Event I D Mea n P value % incr. vs. cent. Gene name Event I D Mea n P value % incr. vs. cent. 4 5 02 1.4 5 02 LYM274 13413. 4 D 7.88 9 4.88E- 02 118.6 LYM129 1257 3.1 B 0.11 4 6.88E- 02 41.7 LYM193 13481. 2 D 4.14 5.04E- 02 14.7 LYM140 1226 1.4 B 0.09 6 7.22E- 02 19.9 LYM40 13732. 1 D 6.93 9 5.19E- 02 92.3 LYM106 1214 1.4 B 0.12 1 7.36E- 02 50.4 LYM122 13712. 1 D 5.60 8 5.71E- 02 55.4 LYM102 1222 2.2 B 0.19 2 7.66E- 02 139.1 LYM164 12813. 8 D 4.76 6 6.09E- 02 32 LYM162 1223 3.2 B 0.11 4 8.96E- 02 42.5 LYM164 12814. 8 D 5.12 6 6.17E- 02 42 LYM140 1226 1.1 B 0.09 6 9.02E- 02 19.5 LYM240 12682. 1 D 8.44 4 6.37E- 02 134 LYM13 1177 2.2 B 0.13 1 9.05E- 02 63.5 LYM260 13095. 7 D 5.14 7 6.73E- 02 42.6 CONTR OL B 0.08 0 LYM274 13413. 1 D 5.52 8 7.60E- 02 53.2 LYM102 1222 2.3 C 1.24 2 0.00E +00 203.7 LYM23 12783. 5 D 4.38 8 7.70E- 02 21.6 LYM102 1222 2.1 C 1.14 8 0.00E +00 180.7 LYM131 12791. 8 D 6.88 2 8.02E- 02 90.7 LYM106 1214 2.1 C 0.74 4 0.00E +00 82.1 LYM193 13484. 3 D 5.01 9 9.01E- 02 39.1 LYM113 1244 4.4 C 0.80 5 0.00E +00 96.9 CONTR OL D 3.60 9 0 LYM113 1244 3.1 C 0.79 4 0.00E +00 94.1 LYM251 13073. 8 E 0.58 4 1.00E- 06 58.3 LYM129 1257 3.5 C 0.86 1 0.00E +00 110.7 LYM251 13074. 6 E 0.57 7 1.00E- 06 56.3 LYM132 1227 6.1 C 0.74 9 0.00E +00 83.3 LYM249 13631. 2 E 0.58 2 4.00E- 06 57.8 LYM148 1217 3.1 C 0.79 8 0.00E +00 95.1 LYM164 12811. 8 E 0.55 1 6.00E- 06 49.2 LYM148 1217 2.1 C 0.73 4 0.00E +00 79.5 LYM217 13181. 6 E 0.56 7 1.50E- 05 53.6 LYM162 1223 4.3 C 0.97 8 0.00E +00 139.2 LYM245 13062. 5 E 0.53 7 3.50E- 05 45.6 LYM162 1223 1.2 C 0.73 2 0.00E +00 79 LYM245 13064. 8 E 0.52 2 1.42E- 04 41.5 LYM268 1248 2.3 C 0.78 4 0.00E +00 91.8 LYM122 13713. 2 E 0.52 2 2.35E- 04 41.5 LYM268 1248 3.4 C 0.76 2 0.00E +00 86.3 LYM164 12813. 5 E 0.54 4 2.41E- 04 47.5 LYM268 1248 3.2 C 0.74 0.00E +00 81 LYM122 13712. 3 E 0.51 9 2.99E- 04 40.7 LYM289 1249 2.2 C 0.84 5 0.00E +00 106.7 LYM251 13073. 7 E 0.52 7 4.09E- 04 42.7 LYM289 1249 1.1 C 0.78 9 0.00E +00 92.9 LYM273 13722. 4 E 0.50 5 9.21E- 04 36.9 LYM289 1249 3.6 C 0.78 5 0.00E +00 92 LYM273 13723. 1 E 0.50 2 1.54E- 03 36.1 LYM289 1249 3.2 C 0.72 1 0.00E +00 76.4 2016213786 11 Aug 2016 380 Gene name Event I D Mea n P value % incr. vs. cent. Gene name Event I D Mea n P value % incr. vs. cent. LYM23 12783. 7 E 0.49 3 2.29E- 03 33.5 LYM290 1250 2.4 C 0.77 7 O.OOE +00 90 LYM131 12791. 8 E 0.48 7 2.71E- 03 31.9 LYM148 1217 3.5 c 0.71 1 1.00E- 06 73.9 LYM251 13072. 8 E 0.49 8 2.78E- 03 35 LYM268 1248 2.1 c 0.77 2 1.00E- 06 88.9 LYM260 13095. 7 E 0.49 1 3.02E- 03 32.9 LYM290 1250 1.2 c 0.72 4 1.00E- 06 77.1 LYM249 13631. 1 E 0.48 9 3.23E- 03 32.5 LYM129 1257 1.3 c 0.77 6 2.00E- 06 89.9 LYM249 13631. 4 E 0.49 8 3.49E- 03 34.8 LYM162 1223 1.3 c 0.74 6 2.00E- 06 82.5 LYM131 12793. 3 E 0.48 6 3.59E- 03 31.8 LYM102 1222 2.2 c 0.74 8 5.00E- 06 83.1 LYM251 13072. 6 E 0.48 3 4.03E- 03 31 LYM10 1174 4.5 c 0.71 1 7.00E- 06 73.8 LYM79 13132. 2 E 0.47 8 5.43E- 03 29.6 LYM134 1231 4.2 c 0.65 8 2.30E- 05 61 LYM79 13134. 3 E 0.47 3 7.86E- 03 28 LYM10 1174 1.4 c 0.68 3 2.80E- 05 67 LYM193 13482. 4 E 0.47 8 8.17E- 03 29.6 LYM113 1244 2.1 c 0.64 8 3.30E- 05 58.5 LYM79 13133. 1 E 0.48 1 8.28E- 03 30.4 LYM13 1177 4.1 c 0.64 1 3.30E- 05 56.7 LYM274 13415. 2 E 0.47 5 9.01E- 03 28.6 LYM134 1231 1.2 c 0.65 1 7.30E- 05 59.3 LYM40 13734. 2 E 0.46 9 9.05E- 03 27.2 LYM289 1249 1.4 c 0.65 4 1.15E- 04 60 LYM260 13095. 1 E 0.49 6 1.32E- 02 34.3 LYM148 1217 1.2 c 0.60 8 1.49E- 04 48.7 LYM224 13434. 2 E 0.46 6 1.34E- 02 26.4 LYM140 1226 1.4 c 0.62 2 1.52E- 04 52.1 LYM79 13133. 3 E 0.46 5 1.55E- 02 25.9 LYM134 1231 2.4 c 0.61 6 1.68E- 04 50.6 LYM164 12814. 7 E 0.46 7 1.71E- 02 26.5 LYM148 1217 4.1 c 0.60 8 1.69E- 04 48.6 LYM274 13413. 4 E 0.47 5 2.10E- 02 28.6 LYM106 1214 2.2 c 0.64 7 2.21E- 04 58.2 LYM40 13732. 1 E 0.47 5 2.15E- 02 28.7 LYM268 1248 1.1 c 0.63 9 2.23E- 04 56.3 LYM40 13732. 2 E 0.46 2.66E- 02 24.6 LYM290 1250 2.1 c 0.61 4.18E- 04 49.3 LYM260 13095. 8 E 0.46 2 2.67E- 02 25.3 LYM290 1250 4.1 c 0.60 9 6.87E- 04 48.9 LYM23 12784. 6 E 0.45 3 2.97E- 02 22.8 LYM113 1244 4.5 c 0.59 6 7.01E- 04 45.7 LYM274 13414. 2 E 0.45 7 2.97E- 02 23.7 LYM102 1222 1.1 c 0.64 8 1.55E- 03 58.5 LYM240 12682. 1 E 0.46 2 4.66E- 02 25.1 LYM3 1204 2.1 c 0.57 2.95E- 03 39.4 LYM23 12782. 6 E 0.45 1 5.25E- 02 22.2 LYM129 1257 3.1 c 0.58 1 3.85E- 03 42.1 LYM193 13481. E 0.43 6.58E- 18.9 LYM140 1226 c 0.57 4.08E- 40.5 2016213786 11 Aug 2016 381 Gene name Event I D Mea n P value % incr. vs. cent. Gene name Event I D Mea n P value % incr. vs. cent. 2 9 02 2.3 4 03 LYM23 12783. 8 E 0.43 8 8.19E- 02 18.6 LYM134 1231 2.3 C 0.56 7 4.13E- 03 38.6 LYM224 13435. 5 E 0.43 8 8.43E- 02 18.8 LYM10 1174 1.2 c 0.55 9 4.92E- 03 36.8 LYM273 13722. 3 E 0.44 9.76E- 02 19.3 LYM132 1227 3.2 c 0.56 3 5.24E- 03 37.6 CONTR OL E 0.36 9 0 LYM290 1250 1.3 c 0.55 2 5.82E- 03 34.9 LYM131 12791. 8 F 6.80 9 0.00E +00 41.1 LYM106 1214 1.4 c 0.57 7 7.47E- 03 41.2 LYM251 13073. 8 F 7.17 8 0.00E +00 48.8 LYM140 1226 1.1 c 0.54 1.12E- 02 32.2 LYM251 13074. 6 F 7.04 2 0.00E +00 46 LYM3 1204 1.1 c 0.54 7 1.19E- 02 33.7 LYM251 13073. 7 F 6.98 8 0.00E +00 44.9 LYM132 1227 1.4 c 0.56 5 1.23E- 02 38.3 LYM251 13072. 6 F 6.46 5 0.00E +00 34 LYM10 1174 2.2 c 0.56 9 1.23E- 02 39.3 LYM40 13734. 2 F 5.90 2 0.00E +00 22.3 LYM140 1226 2.2 c 0.56 1.42E- 02 36.9 LYM249 13631. 3 F 5.61 7 1.00E- 06 16.4 LYM13 1177 2.1 c 0.53 1.46E- 02 29.6 LYM164 12811. 8 F 5.94 1 2.00E- 06 23.1 LYM3 1204 1.2 c 0.52 4 2.55E- 02 28.1 LYM79 13134. 3 F 5.85 2 2.00E- 06 21.3 LYM129 1257 2.2 c 0.52 1 3.13E- 02 27.5 LYM245 13064. 8 F 6.21 5 3.00E- 06 28.8 LYM102 1222 2.6 c 0.52 2 3.24E- 02 27.7 LYM274 13415. 2 F 6.45 4 1.40E- 05 33.8 LYM13 1177 2.2 c 0.51 6 4.80E- 02 26.2 LYM274 13413. 4 F 6.96 3 4.00E- 05 44.3 LYM132 1227 5.1 c 0.50 1 6.79E- 02 22.6 LYM193 13481. 2 F 5.96 8.50E- 05 23.5 LYM162 1223 4.4 c 0.50 1 6.95E- 02 22.5 LYM79 13132. 2 F 6.12 2 1.83E- 04 26.9 LYM13 1177 1.6 c 0.51 9 7.56E- 02 26.9 LYM122 13714. 4 F 6.25 4 3.39E- 04 29.6 LYM140 1226 1.2 c 0.50 2 8.74E- 02 22.7 LYM122 13712. 1 F 6.19 3.43E- 04 28.3 LYM3 1204 3.2 c 0.49 4 9.78E- 02 20.9 LYM245 13062. 5 F 5.76 8 3.71E- 04 19.6 CONTR OL c 0.40 9 0 LYM249 13631. 2 F 6.98 7 4.32E- 04 44.8 LYM268 1248 2.3 D 6.51 6 0.00E +00 87.6 LYM193 13482. 4 F 6.30 8 4.55E- 04 30.8 LYM268 1248 3.4 D 6.28 8 2.00E- 06 81 LYM217 13181. 6 F 6.75 3 5.78E- 04 40 LYM148 1217 1.2 D 5.18 9 4.00E- 05 49.4 LYM164 12814. 8 F 5.56 1 7.94E- 04 15.3 LYM289 1249 2.2 D 7.22 3 7.40E- 05 107.9 LYM131 12793. 3 F 6.00 3 1.10E-03 24.4 LYM148 1217 4.1 D 5.09 6 9.60E- 05 46.7 2016213786 11 Aug 2016 382 Gene name Event I D Mea n P value % incr. vs. cent. Gene name Event I D Mea n P value % incr. vs. cent. LYM23 12783. 7 F 6.27 5 1.34E- 03 30.1 LYM140 1226 1.1 D 4.51 2 3.53E- 04 29.9 LYM122 13713. 2 F 6.76 5 1.65E- 03 40.2 LYM13 1177 2.1 D 4.46 7 8.33E- 04 28.6 LYM245 13061. 6 F 6.11 7 3.30E- 03 26.8 LYM148 1217 3.1 D 6.76 7 1.30E- 03 94.8 LYM273 13722. 4 F 6.08 9 3.52E- 03 26.2 LYM290 1250 2.4 D 6.42 5 2.00E- 03 85 LYM164 12813. 5 F 6.91 5 5.03E- 03 43.3 LYM162 1223 4.3 D 8.82 2.51E- 03 153.9 LYM249 13631. 1 F 5.83 5.49E- 03 20.8 LYM162 1223 1.2 D 6.02 6 2.51E- 03 73.5 LYM273 13723. 1 F 6.30 3 5.56E- 03 30.6 LYM289 1249 3.6 D 6.41 3 2.68E- 03 84.6 LYM40 13732. 1 F 6.44 6 6.08E- 03 33.6 LYM289 1249 3.2 D 5.99 7 3.69E- 03 72.6 LYM224 13435. 1 F 6.00 1 6.99E- 03 24.4 LYM132 1227 6.1 D 6.25 7 4.48E- 03 80.1 LYM240 12682. 1 F 6.59 4 9.82E- 03 36.7 LYM113 1244 2.1 D 5.43 5 4.57E- 03 56.5 LYM122 13712. 3 F 5.82 2 1.17E- 02 20.7 LYM290 1250 1.3 D 4.57 3 5.64E- 03 31.7 LYM224 13435. 5 F 5.72 6 1.24E- 02 18.7 LYM13 1177 4.1 D 5.36 3 6.31E- 03 54.4 LYM249 13633. 1 F 6.40 5 1.51E- 02 32.8 LYM132 1227 5.3 D 4.07 6 6.87E- 03 17.3 LYM40 13732. 2 F 6.01 5 1.52E- 02 24.7 LYM148 1217 3.5 D 5.83 6 6.99E- 03 68 LYM274 13414. 2 F 5.79 2 1.60E- 02 20.1 LYM106 1214 2.1 D 6.27 9 7.68E- 03 80.8 LYM224 13432. 1 F 5.18 4 1.77E- 02 7.5 LYM113 1244 4.4 D 6.70 6 9.46E- 03 93 LYM249 13631. 4 F 6.1 2.05E- 02 26.4 LYM113 1244 4.5 D 4.96 5 1.05E- 02 42.9 LYM260 13095. 7 F 5.94 3 2.05E- 02 23.2 LYM102 1222 2.3 D 10.3 47 1.06E- 02 197.9 LYM260 13095. 1 F 6.16 5 2.12E- 02 27.8 LYM289 1249 1.1 D 6.56 1.24E- 02 88.8 LYM251 13072. 8 F 5.90 1 2.20E- 02 22.3 LYM113 1244 3.1 D 6.78 4 1.25E- 02 95.3 LYM164 12814. 7 F 5.8 2.60E- 02 20.2 LYM268 1248 3.2 D 6.26 3 1.30E- 02 80.3 LYM274 13413. 1 F 5.83 4 2.70E- 02 20.9 LYM134 1231 2.4 D 5.22 4 1.38E- 02 50.4 LYM193 13484. 4 F 5.59 9 3.59E- 02 16.1 LYM134 1231 4.2 D 5.60 9 1.45E- 02 61.5 LYM79 13133. 1 F 5.78 2 4.30E- 02 19.8 LYM148 1217 2.1 D 6.05 5 1.59E- 02 74.3 LYM273 13721. 3 F 5.38 6 4.48E- 02 11.6 LYM140 1226 1.4 D 5.19 2 1.62E- 02 49.5 LYM79 13133. 3 F 5.45 2 4.87E- 02 13 LYM290 1250 1.2 D 6.09 7 1.82E- 02 75.5 LYM23 12782. F 5.25 6.38E- 00 00* LYM129 1257 D 7.10 2.09E- 104.6 2016213786 11 Aug 2016 383 Gene name Event I D Mea n P value % incr. vs. cent. Gene name Event I D Mea n P value % incr. vs. cent. 1 1 02 3.5 1 02 LYM260 13095. 8 F 5.58 8 9.86E- 02 15.8 LYM290 1250 2.1 D 5.03 8 2.88E- 02 45 CONTR OL F 4.82 4 0 LYM3 1204 2.1 D 4.82 3 3.26E- 02 38.8 LYM224 13435. 3 G 0.76 4 0.00E +00 72.3 LYM162 1223 1.3 D 6.43 4 3.53E- 02 85.2 LYM40 13734. 2 G 0.56 7 1.08E- 04 27.9 LYM134 1231 1.2 D 5.55 8 3.62E- 02 60 LYM273 13722. 4 G 0.85 6 4.09E- 04 93.1 LYM102 1222 2.1 D 9.50 6 3.77E- 02 173.6 LYM273 13721. 1 G 0.70 1 6.35E- 04 58.1 LYM129 1257 2.2 D 4.35 3.96E- 02 25.2 LYM273 13721. 3 G 1.06 3 7.82E- 04 139.6 LYM10 1174 1.4 D 5.71 2 4.08E- 02 64.4 LYM122 13712. 3 G 0.63 2 8.84E- 04 42.4 LYM129 1257 1.3 D 6.49 5 4.89E- 02 87 LYM251 13073. 8 G 0.87 9 1.02E- 03 98.3 LYM3 1204 3.2 D 4.15 2 5.04E- 02 19.5 LYM23 12783. 5 G 0.66 3 1.60E- 03 49.5 LYM10 1174 4.5 D 5.88 6 5.04E- 02 69.4 LYM164 12813. 5 G 0.82 4 3.06E- 03 85.8 LYM132 1227 5.1 D 4.22 8 5.06E- 02 21.7 LYM249 13633. 1 G 0.94 4 3.80E- 03 112.9 LYM10 1174 1.2 D 4.70 1 5.08E- 02 35.3 LYM79 13132. 2 G 0.88 1 4.30E- 03 98.7 LYM268 1248 2.1 D 6.36 5.11E- 02 83.1 LYM217 13182. 1 G 0.79 7 5.62E- 03 79.6 LYM134 1231 2.3 D 4.74 2 5.15E- 02 36.5 LYM23 12783. 7 G 0.87 1 6.19E- 03 96.5 LYM102 1222 2.2 D 6.47 6 5.30E- 02 86.4 LYM193 13484. 3 G 0.77 7.00E- 03 73.6 LYM268 1248 1.1 D 5.36 4 5.40E- 02 54.4 LYM249 13631. 1 G 0.69 6 7.39E- 03 56.9 LYM162 1223 4.4 D 4.15 4 5.73E- 02 19.6 LYM251 13072. 8 G 0.80 7 8.13E- 03 82 LYM290 1250 4.1 D 5.10 5 5.84E- 02 47 LYM122 13713. 2 G 0.72 1 8.93E- 03 62.6 LYM3 1204 1.1 D 4.53 8 6.02E- 02 30.7 LYM274 13414. 2 G 0.89 5 1.25E- 02 101.9 LYM132 1227 3.2 D 4.75 5 6.21E- 02 36.9 LYM224 13435. 5 G 0.54 9 1.36E- 02 23.7 LYM106 1214 2.2 D 5.33 5 6.22E- 02 53.6 LYM79 13133. 3 G 0.65 2 1.38E- 02 47.1 LYM289 1249 1.4 D 5.47 2 6.26E- 02 57.5 LYM217 13181. 11 G 0.67 7 1.41E- 02 52.7 LYM3 1204 1.2 D 4.40 2 6.70E- 02 26.7 LYM273 13723. 1 G 0.82 5 1.50E- 02 86 LYM102 1222 2.6 D 4.51 8 8.47E- 02 30.1 LYM122 13714. 4 G 0.93 9 1.71E- 02 111.7 LYM140 1226 2.3 D 4.82 6 8.91E- 02 38.9 LYM251 13073. 7 G 0.96 4 1.78E- 02 117.4 LYM129 1257 3.1 D 4.88 8 9.60E- 02 40.7 2016213786 11 Aug 2016 384 Gene name Event I D Mea n P value % incr. vs. cent. Gene name Event I D Mea n P value % incr. vs. cent. LYM274 13411. 2 G 0.53 2.47E- 02 19.6 CONTR OL D 3.47 4 0 LYM245 13062. 5 G 0.74 2 2.75E- 02 67.4 LYM129 1257 3.5 E 0.70 9 4.00E- 06 62.2 LYM23 12782. 6 G 0.79 4 2.84E- 02 79.1 LYM289 1249 3.6 E 0.69 7 7.00E- 06 59.3 LYM274 13413. 4 G 0.79 1 3.21E- 02 78.4 LYM162 1223 1.2 E 0.65 9 7.90E- 05 50.8 LYM122 13712. 1 G 0.69 5 3.25E- 02 56.7 LYM102 1222 2.3 E 0.67 5 8.60E- 05 54.3 LYM245 13061. 6 G 0.82 3.44E- 02 84.9 LYM290 1250 2.4 E 0.63 2 2.93E- 04 44.5 LYM23 12784. 6 G 0.75 2 3.82E- 02 69.6 LYM148 1217 3.5 E 0.62 5 5.90E- 04 43 LYM251 13072. 6 G 0.90 7 3.90E- 02 104.5 LYM102 1222 2.1 E 0.63 8 7.08E- 04 46 LYM251 13074. 6 G 0.64 3 3.93E- 02 45.1 LYM290 1250 1.2 E 0.62 2 7.15E- 04 42.1 LYM40 13732. 2 G 0.56 3 4.57E- 02 27 LYM268 1248 2.3 E 0.61 3 1.36E- 03 40.2 LYM23 12782. 7 G 0.54 1 4.89E- 02 22 LYM10 1174 4.5 E 0.60 7 1.97E- 03 38.8 LYM217 13181. 7 G 0.56 2 5.20E- 02 26.7 LYM148 1217 2.1 E 0.6 2.71E- 03 37.1 LYM217 13183. 2 G 0.91 3 5.21E- 02 106 LYM148 1217 4.1 E 0.59 1 3.47E- 03 35.1 LYM164 12813. 8 G 0.65 5.77E- 02 46.5 LYM140 1226 1.4 E 0.59 4.44E- 03 34.9 LYM273 13722. 3 G 0.63 9 5.87E- 02 44.1 LYM268 1248 3.4 E 0.59 5 4.63E- 03 36.1 LYM224 13435. 1 G 0.92 7 5.89E- 02 108.9 LYM268 1248 3.2 E 0.58 6 5.11E- 03 34.1 LYM217 13181. 6 G 0.62 2 6.07E- 02 40.2 LYM113 1244 3.1 E 0.58 7.96E- 03 32.6 LYM274 13415. 2 G 0.71 8 6.41E- 02 61.8 LYM289 1249 1.1 E 0.57 2 1.03E- 02 30.8 LYM240 12682. 1 G 0.80 8 6.42E- 02 82.2 LYM289 1249 2.2 E 0.58 2 1.07E- 02 33.1 LYM79 13133. 1 G 0.60 4 6.96E- 02 36.2 LYM132 1227 3.2 E 0.56 6 1.31E-02 29.5 LYM224 13434. 2 G 0.64 3 7.21E- 02 44.9 LYM290 1250 1.3 E 0.56 6 1.39E- 02 29.4 LYM122 13714. 2 G 0.78 8.03E- 02 75.9 LYM106 1214 2.2 E 0.56 5 1.55E- 02 29.3 LYM245 13064. 8 G 0.56 9 8.26E- 02 28.3 LYM10 1174 2.2 E 0.56 8 1.60E- 02 30 LYM40 13732. 1 G 0.68 8.52E- 02 53.3 LYM13 1177 4.1 E 0.56 2 1.77E- 02 28.5 LYM249 13631. 2 G 0.80 4 8.60E- 02 81.3 LYM113 1244 4.4 E 0.55 4 2.37E- 02 26.7 LYM23 12783. 8 G 0.5 8.97E- 02 12.7 LYM134 1231 1.2 E 0.55 3 2.63E- 02 26.4 LYM79 13134. G 0.55 9.71E- 25.7 LYM10 1174 E 0.55 2.69E- 26.7 2016213786 11 Aug 2016 385 Gene name Event I D Mea n P value % incr. vs. cent. Gene name Event I D Mea n P value % incr. vs. cent. 3 1 02 1.4 4 02 CONTR OL G 0.44 3 0 LYM10 1174 1.2 E 0.54 8 3.19E- 02 25.4 LYM122 13714. 4 H 0.09 5 0.00E +00 118.7 LYM132 1227 5.1 E 0.55 1 3.90E- 02 26 LYM122 13713. 2 H 0.07 2 0.00E +00 66.2 LYM132 1227 6.1 E 0.55 3.90E- 02 25.8 LYM122 13712. 3 H 0.06 4 0.00E +00 47 LYM290 1250 4.1 E 0.54 8 4.08E- 02 25.2 LYM164 12813. 5 H 0.08 0.00E +00 84.1 LYM129 1257 1.3 E 0.54 9 4.67E- 02 25.5 LYM193 13484. 3 H 0.07 3 0.00E +00 67 LYM289 1249 3.2 E 0.54 1 5.42E- 02 23.7 LYM217 13183. 2 H 0.08 9 0.00E +00 104.8 LYM289 1249 1.4 E 0.54 3 5.79E- 02 24.1 LYM217 13182. 1 H 0.08 4 0.00E +00 93 LYM113 1244 2.1 E 0.54 6.19E- 02 23.4 LYM217 13181. 11 H 0.06 9 0.00E +00 58.8 LYM102 1222 2.2 E 0.54 1 6.54E- 02 23.6 LYM224 13435. 3 H 0.07 0.00E +00 60.5 LYM134 1231 4.2 E 0.53 7.02E- 02 21.2 LYM23 12783. 7 H 0.08 9 0.00E +00 104 LYM102 1222 2.6 E 0.52 4 9.02E- 02 19.9 LYM23 12782. 6 H 0.08 2 0.00E +00 89 LYM140 1226 2.3 E 0.53 1 9.82E- 02 21.4 LYM23 12784. 6 H 0.07 3 0.00E +00 68.3 CONTR OL E 0.43 7 0 LYM23 12783. 5 H 0.06 6 0.00E +00 51.8 LYM129 1257 3.5 F 7.52 9 0.00E +00 48.8 LYM245 13061. 6 H 0.08 1 0.00E +00 85.2 LYM148 1217 4.1 F 6.57 6 0.00E +00 30 LYM245 13062. 5 H 0.07 8 0.00E +00 79.4 LYM102 1222 2.6 F 6.33 1 1.00E- 06 25.2 LYM249 13633. 1 H 0.09 8 0.00E +00 123.9 LYM134 1231 1.2 F 6.31 4 1.00E- 06 24.8 LYM249 13631. 1 H 0.06 8 0.00E +00 56.9 LYM290 1250 2.4 F 6.93 4 3.00E- 06 37.1 LYM251 13073. 7 H 0.09 7 0.00E +00 122.4 LYM132 1227 3.2 F 6.46 8 8.00E- 06 27.9 LYM251 13073. 8 H 0.08 8 0.00E +00 102.1 LYM289 1249 1.1 F 6.65 7 2.20E- 05 31.6 LYM251 13072. 6 H 0.08 7 0.00E +00 100.7 LYM290 1250 1.3 F 6.05 9 4.00E- 05 19.8 LYM251 13072. 8 H 0.08 7 0.00E +00 99.1 LYM134 1231 4.2 F 6.20 4 7.70E- 05 22.6 LYM251 13074. 6 H 0.06 8 0.00E +00 56.4 LYM148 1217 3.1 F 6.77 1.40E- 04 33.8 LYM273 13721. 3 H 0.10 6 0.00E +00 143.3 LYM13 1177 4.1 F 6.45 9 1.53E- 04 27.7 LYM273 13723. 1 H 0.08 9 0.00E +00 104 LYM290 1250 1.2 F 6.82 3 1.66E- 04 34.9 LYM273 13722. 4 H 0.08 1 0.00E +00 85.6 LYM113 1244 4.4 F 6.32 5 1.73E- 04 25 2016213786 11 Aug 2016 386 Gene name Event I D Mea n P value % incr. vs. cent. Gene name Event I D Mea n P value % incr. vs. cent. LYM273 13721. 1 H 0.07 4 0.00E +00 70.2 LYM10 1174 4.5 F 7.04 4 1.83E- 04 39.3 LYM273 13722. 3 H 0.06 7 0.00E +00 54.8 LYM268 1248 3.2 F 6.83 1.89E- 04 35 LYM274 13414. 2 H 0.09 4 0.00E +00 115.6 LYM289 1249 2.2 F 6.92 6 2.40E- 04 36.9 LYM274 13413. 4 H 0.07 8 0.00E +00 78.9 LYM289 1249 3.6 F 7.10 8 4.29E- 04 40.5 LYM79 13132. 2 H 0.09 5 0.00E +00 117 LYM148 1217 2.1 F 6.75 4 6.38E- 04 33.5 LYM79 13133. 3 H 0.07 0.00E +00 60.2 LYM268 1248 2.3 F 6.81 4 7.13E- 04 34.7 LYM217 13181. 6 H 0.06 6 1.00E- 06 51.9 LYM113 1244 3.1 F 6.92 5 9.38E- 04 36.9 LYM249 13631. 2 H 0.08 5 1.00E- 06 95.9 LYM140 1226 1.4 F 6.84 7 1.17E- 03 35.4 LYM274 13415. 2 H 0.07 4 1.00E- 06 69.9 LYM148 1217 3.5 F 6.56 8 1.48E- 03 29.8 LYM79 13133. 1 H 0.06 4 1.00E- 06 47.7 LYM113 1244 4.5 F 6.07 9 1.72E- 03 20.2 LYM164 12813. 8 H 0.06 7 2.00E- 06 54 LYM102 1222 2.1 F 7.22 6 2.12E- 03 42.8 LYM224 13435. 1 H 0.08 9 2.00E- 06 104.8 LYM10 1174 1.2 F 5.97 6 2.26E- 03 18.1 LYM240 12682. 1 H 0.08 2 2.00E- 06 89 LYM106 1214 2.2 F 6.15 8 2.57E- 03 21.7 LYM122 13714. 2 H 0.07 7 5.00E- 06 77.8 LYM162 1223 1.2 F 6.89 9 2.78E- 03 36.4 LYM40 13734. 2 H 0.05 6 5.00E- 06 28.3 LYM10 1174 1.4 F 6.12 8 3.19E- 03 21.2 LYM122 13712. 1 H 0.06 3 1.70E- 05 43.7 LYM148 1217 1.2 F 6.27 6 4.06E- 03 24.1 LYM224 13434. 2 H 0.06 4 2.70E- 05 47.3 LYM162 1223 4.3 F 6.65 1 5.16E- 03 31.5 LYM40 13732. 1 H 0.06 8 3.00E- 05 55.4 LYM268 1248 3.4 F 6.74 6 5.50E- 03 33.4 LYM217 13181. 7 H 0.05 7 9.40E- 05 31.2 LYM102 1222 2.3 F 7.19 8 7.29E- 03 42.3 LYM79 13134. 3 H 0.05 7 1.09E- 04 31.8 LYM289 1249 3.2 F 6.30 5 7.70E- 03 24.6 LYM260 13095. 7 H 0.06 3 1.15E- 04 45.5 LYM113 1244 2.1 F 6.43 8 1.27E- 02 27.3 LYM23 12782. 7 H 0.05 6 1.57E- 04 28 LYM102 1222 2.2 F 6.67 7 1.28E- 02 32 LYM40 13732. 2 H 0.05 6 1.93E- 04 28.4 LYM290 1250 4.1 F 6.29 6 1.34E- 02 24.5 LYM131 12791. 5 H 0.06 3.33E- 04 37.3 LYM132 1227 5.1 F 6.32 2 1.46E- 02 25 LYM245 13064. 8 H 0.05 7 4.25E- 04 29.9 LYM132 1227 5.3 F 5.86 3 1.47E- 02 15.9 LYM274 13411. 2 H 0.05 3 6.16E- 04 22.6 LYM132 1227 6.1 F 6.53 6 1.48E- 02 29.2 LYM79 13134. H 0.05 1.51E- 24.6 LYM106 1214 F 6.22 1.59E- 23 2016213786 11 Aug 2016 387 Gene name Event I D Mea n P value % incr. vs. cent. Gene name Event I D Mea n P value % incr. vs. cent. 2 4 03 2.1 02 LYM260 13095. 1 H 0.07 2.31E-03 61.7 LYM10 1174 2.2 F 6.22 6 1.66E- 02 23.1 LYM23 12783. 8 H 0.05 2 2.84E- 03 18.8 LYM106 1214 1.4 F 5.81 1 2.02E- 02 14.9 LYM274 13413. 1 H 0.05 5 9.12E- 03 25.3 LYM162 1223 1.3 F 6.50 8 2.18E- 02 28.7 LYM249 13631. 4 H 0.05 1 9.60E- 03 17.4 LYM129 1257 1.3 F 6.49 9 3.26E- 02 28.5 LYM164 12814. 8 H 0.06 1 1.06E- 02 39.9 LYM13 1177 2.2 F 6.13 3.39E- 02 21.2 LYM224 13435. 5 H 0.05 1.25E- 02 15.3 LYM132 1227 1.4 F 5.81 4 4.00E- 02 14.9 LYM131 12791. 8 H 0.06 4 1.66E- 02 47.4 LYM13 1177 2.1 F 5.74 3 6.50E- 02 13.5 LYM193 13482. 4 H 0.05 5 2.52E- 02 26.1 LYM129 1257 3.1 F 5.78 3 6.75E- 02 14.3 LYM260 13095. 8 H 0.05 2 4.62E- 02 19.8 LYM13 1177 3.2 F 5.50 5 6.85E- 02 8.8 LYM224 13432. 1 H 0.04 9 4.71E- 02 13 LYM3 1204 2.1 F 5.67 3 6.99E- 02 12.1 CONTR OL H 0.04 4 0 LYM268 1248 1.1 F 6.05 6 7.44E- 02 19.7 LYM122 13711. 3 A 0.01 1 1.00E- 06 231.7 LYM134 1231 2.4 F 6.02 8 9.99E- 02 19.2 LYM234 14093. 2 A 0.01 2.10E- 05 192.5 CONTR OL F 5.05 8 0 LYM189 13315. 2 A 0.01 5.08E- 04 197.1 LYM134 1231 2.4 G 0.70 4 0.00E +00 57.1 LYM217 13183. 2 A 0.00 8 5.11E- 04 130.3 LYM140 1226 1.2 G 0.63 6 0.00E +00 42 LYM189 13314. 5 A 0.00 5 9.45E- 04 67.4 LYM162 1223 4.3 G 0.91 2 1.00E- 06 103.5 LYM79 13134. 3 A 0.00 5 9.97E- 04 62 LYM290 1250 2.4 G 0.66 7 1.30E- 05 48.9 LYM161 13233. 5 A 0.00 7 1.28E- 03 124.2 LYM162 1223 4.4 G 0.75 5.67E- 04 67.5 LYM217 13186. 1 A 0.01 2 1.32E- 03 275.4 LYM140 1226 2.2 G 0.90 3 6.14E- 04 101.7 LYM217 13181. 9 A 0.00 8 1.81E- 03 134.2 LYM132 1227 6.1 G 0.82 1 1.92E- 03 83.4 LYM32 13964. 1 A 0.00 8 2.09E- 03 144.9 LYM140 1226 1.4 G 0.54 3 2.25E- 03 21.2 LYM234 14092. 5 A 0.01 2 2.20E- 03 277 LYM13 1177 2.2 G 0.63 4 3.99E- 03 41.6 LYM240 12683. 5 A 0.01 2.37E- 03 192.5 LYM289 1249 2.2 G 0.88 4.21E- 03 96.5 LYM219 13332. 9 A 0.01 1 3.78E- 03 233.2 LYM132 1227 1.4 G 0.60 9 4.24E- 03 36 LYM278 13364. 5 A 0.00 4 3.79E- 03 24.4 LYM289 1249 1.1 G 0.69 1 5.40E- 03 54.3 LYM245 13061. 8 A 0.01 3 3.90E- 03 306.9 LYM268 1248 2.1 G 0.93 6 6.27E- 03 108.9 2016213786 11 Aug 2016 388 Gene name Event I D Mea n P value % incr. vs. cent. Gene name Event I D Mea n P value % incr. vs. cent. LYM234 14092. 1 A 0.00 5 5.44E- 03 42 LYM3 1204 1.2 G 0.66 1 6.62E- 03 47.6 LYM74 13954. 1 A 0.01 4 8.73E- 03 315.4 LYM162 1223 1.3 G 0.74 8 7.40E- 03 67 LYM74 13954. 2 A 0.00 9 1.17E- 02 175.6 LYM268 1248 3.4 G 0.71 7 7.99E- 03 60.2 LYM188 13244. 6 A 0.00 5 1.21E- 02 53.6 LYM290 1250 4.1 G 0.56 2 8.97E- 03 25.4 LYM189 13311. 3 A 0.00 9 1.35E- 02 186.4 LYM3 1204 3.2 G 0.63 5 9.85E- 03 41.8 LYM189 13311. 2 A 0.01 1.83E- 02 194.8 LYM148 1217 3.1 G 0.84 9 1.05E- 02 89.5 LYM274 13415. 2 A 0.01 2 1.98E- 02 273.9 LYM13 1177 4.1 G 0.78 9 1.16E- 02 76.1 LYM79 13132. 2 A 0.01 3 2.07E- 02 300 LYM140 1226 1.1 G 0.52 1 1.27E- 02 16.3 LYM217 13182. 1 A 0.01 2 2.10E- 02 269.3 LYM106 1214 2.1 G 0.91 9 1.37E- 02 105.3 LYM240 12682. 1 A 0.01 2 2.22E- 02 264.7 LYM134 1231 2.3 G 0.78 1 1.42E- 02 74.4 LYM189 13315. 1 A 0.01 7 2.23E- 02 422.8 LYM3 1204 2.1 G 0.69 3 2.41E- 02 54.8 LYM188 13244. 7 A 0.00 6 2.61E- 02 87.3 LYM113 1244 2.1 G 0.70 2 2.51E- 02 56.8 LYM79 13133. 2 A 0.00 9 3.08E- 02 161.8 LYM102 1222 2.3 G 1.04 2.56E- 02 132.2 LYM79 13133. 3 A 0.00 9 3.18E- 02 183.3 LYM113 1244 4.5 G 0.67 2 3.11E- 02 50 LYM189 13314. 4 A 0.00 9 3.27E- 02 167.9 LYM289 1249 3.2 G 0.74 7 3.12E- 02 66.7 LYM188 13244. 4 A 0.01 3.40E- 02 220.2 LYM129 1257 3.5 G 0.69 3.20E- 02 54.1 LYM79 13134. 1 A 0.01 3.50E- 02 194.8 LYM113 1244 4.4 G 0.64 7 3.21E- 02 44.4 LYM274 13413. 1 A 0.00 9 3.63E- 02 166.4 LYM134 1231 1.2 G 0.70 2 3.87E- 02 56.7 LYM234 14092. 8 A 0.01 2 3.81E- 02 268.5 LYM129 1257 3.1 G 0.58 2 3.90E- 02 30 LYM74 13952. 2 A 0.00 9 3.97E- 02 181 LYM132 1227 5.3 G 0.61 4 3.97E- 02 37 LYM32 13963. 4 A 0.00 8 4.02E- 02 151.8 LYM113 1244 3.1 G 0.86 5 4.24E- 02 93.2 LYM274 13413. 4 A 0.00 9 4.20E- 02 169.5 LYM102 1222 2.1 G 1.12 4 4.88E- 02 151 LYM234 14091. 1 A 0.00 8 4.79E- 02 131.1 LYM106 1214 4.4 G 0.63 8 5.62E- 02 42.4 LYM161 13233. 6 A 0.01 5.45E- 02 220.9 LYM102 1222 2.2 G 0.88 7 6.97E- 02 98.1 LYM240 12683. 9 A 0.00 4 5.60E- 02 28.2 LYM148 1217 2.1 G 0.64 9 7.46E- 02 44.8 LYM79 13131. 1 A 0.00 7 6.26E- 02 116.5 LYM102 1222 1.1 G 0.74 4 7.72E- 02 66.1 LYM32 13963. A 0.00 6.95E- 49.7 LYM10 1174 G 0.55 8.52E- 24.1 2016213786 11 Aug 2016 389 Gene name Event I D Mea n P value % incr. vs. cent. Gene name Event I D Mea n P value % incr. vs. cent. 1 5 02 4.5 6 02 LYM273 13721. 3 A 0.00 6 7.08E- 02 80.4 LYM290 1250 1.2 G 0.66 4 9.90E- 02 48.2 LYM79 13134. 2 A 0.00 4 7.89E- 02 32.8 CONTR OL G 0.44 8 0 LYM217 13181. 6 A 0.00 5 8.18E- 02 61.2 LYM102 1222 2.1 H 0.11 8 0.00E +00 160.6 LYM122 13713. 4 A 0.00 5 9.83E- 02 51.2 LYM102 1222 2.3 H 0.11 3 0.00E +00 149.3 CONTR OL A 0.00 3 0 LYM106 1214 2.1 H 0.09 1 0.00E +00 101.4 LYM161 13233. 5 B 0.14 6 0.00E +00 123.8 LYM132 1227 6.1 H 0.08 4 0.00E +00 85.3 LYM189 13314. 5 B 0.10 3 0.00E +00 57.6 LYM140 1226 2.2 H 0.08 8 0.00E +00 94.1 LYM234 14093. 2 B 0.18 1 3.00E- 06 177.1 LYM148 1217 3.1 H 0.08 4 0.00E +00 86.3 LYM32 13964. 1 B 0.14 5 5.12E- 04 122.8 LYM162 1223 4.3 H 0.09 1 0.00E +00 100.3 LYM234 14092. 5 B 0.21 9 6.15E- 04 235.5 LYM268 1248 2.1 H 0.09 4 0.00E +00 108.2 LYM122 13711. 3 B 0.22 5 6.83E- 04 245.3 LYM289 1249 2.2 H 0.09 2 0.00E +00 104 LYM240 12683. 5 B 0.17 9 8.14E- 04 173.6 LYM13 1177 4.1 H 0.07 9 1.00E- 06 74.4 LYM245 13061. 8 B 0.24 1.32E- 03 268.1 LYM162 1223 4.4 H 0.07 4 3.00E- 06 64.8 LYM217 13186. 1 B 0.19 7 1.61E- 03 202.2 LYM268 1248 3.4 H 0.07 6 3.00E- 06 68.5 LYM217 13183. 2 B 0.14 4 1.66E- 03 120.5 LYM134 1231 2.3 H 0.07 7 4.00E- 06 70 LYM189 13315. 2 B 0.21 2 4.60E- 03 224.4 LYM113 1244 3.1 H 0.08 7 5.00E- 06 91.5 LYM219 13332. 9 B 0.19 4 5.69E- 03 197.9 LYM162 1223 1.3 H 0.07 4 8.00E- 06 63.1 LYM74 13954. 2 B 0.15 7 7.07E- 03 141.3 LYM290 1250 2.4 H 0.07 1 1.30E- 05 57.2 LYM217 13182. 1 B 0.23 1 7.34E- 03 253.5 LYM129 1257 3.5 H 0.07 5 2.20E- 05 66.3 LYM234 14092. 1 B 0.08 7 7.90E- 03 33 LYM134 1231 2.4 H 0.06 9 3.10E- 05 52.5 LYM278 13364. 5 B 0.07 6 8.29E- 03 17 LYM102 1222 2.2 H 0.08 7 7.00E- 05 91.6 LYM74 13954. 1 B 0.24 8 8.32E- 03 280 LYM289 1249 1.1 H 0.06 9 9.40E- 05 53.2 LYM217 13181. 9 B 0.15 1 8.57E- 03 130.7 LYM113 1244 4.4 H 0.07 1 1.12E- 04 56.9 LYM189 13311. 2 B 0.17 4 8.79E- 03 166.7 LYM134 1231 1.2 H 0.07 1 1.62E- 04 57.5 LYM32 13963. 4 B 0.16 3 8.96E- 03 149.3 LYM102 1222 1.1 H 0.07 6 2.25E- 04 68.8 LYM240 12683. 9 B 0.07 7 9.39E- 03 18.7 LYM289 1249 3.2 H 0.07 1 2.37E- 04 57.5 2016213786 11 Aug 2016 390 Gene name Event I D Mea n P value % incr. vs. cent. Gene name Event I D Mea n P value % incr. vs. cent. LYM189 13311. 3 B 0.17 6 1.20E- 02 169 LYM3 1204 2.1 H 0.06 8 4.18E- 04 49.7 LYM79 13134. 1 B 0.17 3 1.36E- 02 165.4 LYM113 1244 2.1 H 0.06 7 7.34E- 04 49.1 LYM79 13133. 3 B 0.16 9 1.42E- 02 158.3 LYM148 1217 2.1 H 0.06 8 8.70E- 04 50.9 LYM240 12682. 1 B 0.20 2 1.49E- 02 209.5 LYM129 1257 1.3 H 0.07 1.22E- 03 54.8 LYM79 13132. 2 B 0.23 7 1.69E- 02 262.6 LYM113 1244 4.5 H 0.06 6 1.82E- 03 45.3 LYM188 13244. 7 B 0.11 6 1.77E- 02 77.9 LYM290 1250 1.2 H 0.06 8 1.94E- 03 50 LYM188 13244. 6 B 0.10 2 2.08E- 02 56.2 LYM3 1204 1.2 H 0.06 3 2.54E- 03 38.7 LYM189 13315. 1 B 0.28 1 2.09E- 02 330 LYM140 1226 1.2 H 0.06 1 4.70E- 03 34.5 LYM79 13134. 2 B 0.08 7 2.10E- 02 33.3 LYM3 1204 3.2 H 0.06 1 6.01E- 03 35.8 LYM189 13314. 4 B 0.15 8 2.19E- 02 141.4 LYM132 1227 5.3 H 0.06 1 9.29E- 03 34.2 LYM188 13244. 4 B 0.19 6 2.23E- 02 200.6 LYM13 1177 2.2 H 0.06 9.79E- 03 32.3 LYM161 13233. 6 B 0.18 5 2.28E- 02 183.3 LYM106 1214 1.4 H 0.06 3 1.25E- 02 39.7 LYM274 13415. 2 B 0.21 7 2.29E- 02 232.4 LYM106 1214 4.4 H 0.06 1.94E- 02 32.6 LYM274 13413. 4 B 0.15 2 2.34E- 02 133.3 LYM268 1248 1.1 H 0.06 1 2.01E- 02 34.4 LYM234 14091. 1 B 0.14 9 2.38E- 02 129 LYM134 1231 4.2 H 0.05 9 2.35E- 02 29.9 LYM79 13133. 2 B 0.15 6 2.45E- 02 139.7 LYM129 1257 3.1 H 0.05 7 3.09E- 02 27.1 LYM79 13134. 3 B 0.10 9 2.50E- 02 67.5 LYM132 1227 1.4 H 0.05 7 3.88E- 02 25.2 LYM273 13721. 3 B 0.11 2 2.82E- 02 71.3 LYM113 1244 2.2 H 0.05 9 3.90E- 02 30 LYM274 13413. 1 B 0.16 7 3.18E- 02 156.6 LYM10 1174 4.5 H 0.05 6 5.50E- 02 24.8 LYM217 13181. 6 B 0.1 3.59E- 02 53.3 LYM290 1250 4.1 H 0.05 6 5.52E- 02 23 LYM234 14092. 8 B 0.20 8 3.90E- 02 219.4 LYM129 1257 2.2 H 0.05 5 9.34E- 02 21.4 LYM32 13963. 1 B 0.09 3 5.12E- 02 42.1 LYM289 1249 1.4 H 0.05 6 9.88E- 02 23.2 LYM74 13952. 2 B 0.15 4 5.75E- 02 136.2 CONTR OL H 0.04 5 0 LYM79 13131. 1 B 0.15 2 6.99E- 02 133.1 LYM248 1350 2.6 A 0.00 4 1.00E- 05 49 LYM161 13234. 6 B 0.13 6 7.51E- 02 108.5 LYM79 1313 4.7 A 0.00 4 6.75E- 04 67 LYM219 13334. 8 B 0.11 4 7.99E- 02 74.8 LYM157 1334 1.4 A 0.00 6 1.12E- 03 127 LYM219 13331. B 0.14 9.01E- 127.7 LYM180 1344 A 0.00 1.29E- 75 2016213786 11 Aug 2016 391 Gene name Event I D Mea n P value % incr. vs. cent. Gene name Event I D Mea n P value % incr. vs. cent. 1 9 02 2.7 4 03 CONTR OL B 0.06 5 0 LYM180 1344 2.6 A 0.00 4 2.39E- 03 78 LYM122 13711. 3 C 0.94 7 0.00E +00 73.9 LYM52 1289 4.6 A 0.00 4 3.08E- 03 50 LYM161 13233. 6 C 1.00 1 0.00E +00 83.9 LYM157 1334 1.1 A 0.00 7 3.26E- 03 182 LYM189 13315. 1 C 1.28 1 0.00E +00 135.3 LYM79 1313 1.6 A 0.00 6 3.45E- 03 146 LYM189 13315. 2 C 1.27 8 0.00E +00 134.6 LYM213 1284 2.8 A 0.00 9 5.95E- 03 260 LYM189 13311. 2 C 1.04 3 0.00E +00 91.5 LYM157 1334 1.3 A 0.01 3 6.38E- 03 420 LYM219 13332. 9 C 1.16 9 0.00E +00 114.6 LYM120 1338 2.2 A 0.00 7 1.08E- 02 192 LYM234 14092. 5 C 1.19 6 0.00E +00 119.5 LYM213 1284 2.9 A 0.00 8 1.10E-02 235 LYM240 12683. 5 C 1.11 4 0.00E +00 104.6 LYM117 1362 4.7 A 0.00 4 1.29E- 02 59 LYM240 12682. 1 C 1.05 3 0.00E +00 93.4 LYM79 1313 2.6 A 0.00 4 1.41E- 02 64 LYM274 13413. 4 C 1.20 5 0.00E +00 121.3 LYM52 1289 5.7 A 0.00 9 1.45E- 02 262 LYM274 13415. 2 C 1.10 8 0.00E +00 103.4 LYM107 1263 1.1 A 0.00 7 1.50E- 02 189 LYM32 13964. 1 c 1.00 1 0.00E +00 83.9 LYM120 1338 2.8 A 0.00 7 1.53E- 02 160 LYM74 13954. 1 c 1.34 6 0.00E +00 147.2 LYM120 1338 2.1 A 0.00 6 1.71E- 02 157 LYM74 13954. 2 c 1.13 3 0.00E +00 108.1 LYM213 1284 1.8 A 0.00 5 1.96E- 02 114 LYM79 13132. 2 c 1.06 6 0.00E +00 95.8 LYM227 1454 2.1 A 0.00 4 2.27E- 02 43 LYM79 13134. 1 c 1.01 8 0.00E +00 86.9 LYM120 1338 2.3 A 0.00 8 2.67E- 02 225 LYM217 13181. 6 c 0.97 4 1.00E- 06 78.9 LYM52 1289 4.7 A 0.01 1 3.21E- 02 334 LYM245 13061. 8 c 0.94 9 1.00E- 06 74.3 LYM227 1454 4.2 A 0.00 4 3.26E- 02 53 LYM32 13963. 4 c 0.94 9 2.00E- 06 74.3 LYM52 1289 4.8 A 0.00 5 3.45E- 02 88 LYM188 13244. 4 c 0.90 7 3.00E- 06 66.6 LYM180 1344 1.7 A 0.00 9 3.65E- 02 259 LYM189 13311. 3 c 0.92 3 3.00E- 06 69.5 LYM248 1350 3.5 A 0.00 4 3.65E- 02 75 LYM234 14091. 1 c 0.98 1 1.40E- 05 80.1 LYM213 1284 1.6 A 0.00 6 3.85E- 02 125 LYM217 13186. 1 c 0.88 9 1.90E- 05 63.3 LYM107 1263 3.4 A 0.00 4 3.86E- 02 71 LYM234 14092. 8 c 0.95 7 1.90E- 05 75.7 LYM117 1362 2.6 A 0.00 4 3.99E- 02 51 LYM234 14093. 2 c 0.87 2 3.90E- 05 60.1 LYM227 1454 2.3 A 0.00 3 4.02E- 02 37 2016213786 11 Aug 2016 392 Gene name Event I D Mea n P value % incr. vs. cent. Gene name Event I D Mea n P value % incr. vs. cent. LYM79 13133. 2 C 0.90 3 5.00E- 05 65.8 LYM227 1454 2.5 A 0.00 3 4.55E- 02 32 LYM74 13952. 2 c 0.95 1.17E- 04 74.4 LYM120 1338 2.4 A 0.00 4 4.58E- 02 59 LYM161 13233. 5 c 0.79 3 3.92E- 04 45.6 LYM248 1350 4.6 A 0.00 3 4.71E- 02 29 LYM274 13413. 1 c 0.91 9 7.62E- 04 68.8 LYM52 1289 1.8 A 0.00 4 5.01E- 02 62 LYM219 13331. 1 c 0.78 8 2.74E- 03 44.8 LYM79 1313 1.5 A 0.00 4 5.09E- 02 54 LYM79 13131. 1 c 0.82 5 3.08E- 03 51.6 LYM107 1263 2.1 A 0.00 4 5.18E- 02 55 LYM240 12683. 9 c 0.75 3 3.59E- 03 38.2 LYM248 1350 2.7 A 0.00 3 5.65E- 02 27 LYM188 13244. 7 c 0.76 7 4.32E- 03 40.8 LYM117 1362 3.9 A 0.00 4 5.72E- 02 63 LYM161 13234. 6 c 0.77 1 5.36E- 03 41.5 LYM157 1334 2.4 A 0.00 3 6.07E- 02 30 LYM79 13133. 3 c 0.76 5 9.03E- 03 40.4 LYM117 1362 1.8 A 0.00 4 6.42E- 02 41 LYM189 13314. 4 c 0.75 9.65E- 03 37.7 LYM180 1344 1.5 A 0.00 7 9.29E- 02 178 LYM273 13721. 3 c 0.70 6 2.08E- 02 29.7 CONTR OL A 0.00 3 0 LYM79 13134. 3 c 0.70 8 2.18E- 02 30 LYM79 1313 2.6 B 0.09 7 0.00E +00 57 LYM188 13244. 6 c 0.67 6 6.45E- 02 24.2 LYM248 1350 2.6 B 0.08 4 3.80E- 05 36.3 LYM234 14092. 1 c 0.66 8.67E- 02 21.2 LYM52 1289 4.6 B 0.07 7 1.17E- 03 24.1 LYM32 13963. 1 c 0.68 6 9.24E- 02 26 LYM120 1338 2.8 B 0.14 3 1.23E- 03 130.6 CONTR OL c 0.54 5 0 LYM213 1284 2.8 B 0.19 7 1.73E- 03 218 LYM32 13964. 1 D 8.65 1 0.00E +00 79.9 LYM157 1334 1.4 B 0.11 7 3.42E- 03 88.4 LYM219 13332. 9 D 10.4 91 1.00E- 05 118.2 LYM227 1454 4.2 B 0.09 3 4.06E- 03 50.6 LYM122 13711. 3 D 8.61 1 5.80E- 05 79.1 LYM120 1338 2.2 B 0.16 4 4.26E- 03 164.9 LYM161 13233. 5 D 7.32 6 1.20E- 04 52.3 LYM107 1263 3.4 B 0.10 2 4.42E- 03 65.5 LYM188 13244. 4 D 8.09 7 2.06E- 04 68.4 LYM52 1289 5.7 B 0.18 5 4.74E- 03 198.5 LYM234 14092. 5 D 10.5 4 7.64E- 04 119.2 LYM117 1362 1.8 B 0.08 3 5.00E- 03 33.8 LYM79 13132. 2 D 9.36 3.54E- 03 94.6 LYM180 1344 2.6 B 0.09 5 5.31E- 03 53.8 LYM74 13954. 2 D 9.85 5 5.72E- 03 104.9 LYM107 1263 1.1 B 0.18 2 5.88E- 03 193.5 LYM189 13315. 2 D 10.9 46 5.76E- 03 127.6 LYM248 1350 4.6 B 0.08 6.04E- 03 29.8 LYM74 13954. D 11.9 6.16E- 149.1 LYM157 1334 B 0.17 6.92E- 183.8 2016213786 11 Aug 2016 393 Gene name Event I D Mea n P value % incr. vs. cent. Gene name Event I D Mea n P value % incr. vs. cent. 1 81 03 1.1 6 03 LYM274 13413. 4 D 10.3 17 7.08E- 03 114.5 LYM157 1334 1.3 B 0.28 9 8.30E- 03 367.8 LYM161 13233. 6 D 8.86 9 8.43E- 03 84.4 LYM120 1338 2.4 B 0.08 7 8.44E- 03 41.4 LYM274 13415. 2 D 9.62 3 8.58E- 03 100.1 LYM79 1313 1.6 B 0.15 3 9.73E- 03 146.6 LYM245 13061. 8 D 8.36 8 8.65E- 03 74 LYM117 1362 2.5 B 0.08 9 1.06E- 02 44 LYM189 13315. 1 D 11.2 93 1.02E- 02 134.8 LYM157 1334 2.4 B 0.09 2 1.14E- 02 49 LYM234 14093. 2 D 7.63 2 1.08E- 02 58.7 LYM120 1338 2.3 B 0.18 9 1.26E- 02 205.1 LYM240 12683. 9 D 6.76 1 1.26E- 02 40.6 LYM52 1289 1.8 B 0.09 9 1.29E- 02 60.4 LYM189 13311. 3 D 8.14 9 1.49E- 02 69.5 LYM227 1454 1.5 B 0.08 6 1.29E- 02 39.2 LYM79 13134. 1 D 9.34 7 1.65E- 02 94.4 LYM213 1284 2.9 B 0.18 3 1.30E- 02 195.5 LYM32 13963. 4 D 8.28 8 1.66E- 02 72.4 LYM180 1344 1.7 B 0.20 3 1.33E- 02 227.8 LYM240 12682. 1 D 9.74 7 1.72E- 02 102.7 LYM120 1338 2.1 B 0.14 9 1.38E- 02 140.6 LYM189 13311. 2 D 8.99 1.94E- 02 87 LYM213 1284 1.6 B 0.12 5 1.59E- 02 102.2 LYM79 13134. 3 D 6.43 1 1.94E- 02 33.7 LYM180 1344 2.7 B 0.10 2 2.04E- 02 64.6 LYM217 13186. 1 D 7.5 1.95E- 02 56 LYM52 1289 4.7 B 0.23 7 2.09E- 02 282.8 LYM217 13181. 6 D 8.44 3 1.96E- 02 75.6 LYM117 1362 2.6 B 0.09 5 2.67E- 02 53.3 LYM273 13721. 3 D 6.13 2 3.30E- 02 27.5 LYM213 1284 1.8 B 0.11 8 2.79E- 02 91.6 LYM234 14092. 1 D 5.87 8 3.41E- 02 22.2 LYM248 1350 3.5 B 0.1 2.95E- 02 62 LYM240 12683. 5 D 9.95 7 3.82E- 02 107.1 LYM227 1454 2.1 B 0.09 6 4.16E- 02 55.3 LYM79 13133. 2 D 8.25 2 4.16E- 02 71.6 LYM213 1284 1.5 B 0.08 9 4.72E- 02 43.5 LYM234 14091. 1 D 8.58 6 5.33E- 02 78.5 LYM117 1362 3.9 B 0.08 9 4.77E- 02 44.2 LYM234 14092. 8 D 8.37 3 5.62E- 02 74.1 LYM248 1350 2.7 B 0.07 6 5.33E- 02 23.7 LYM161 13234. 6 D 7.15 7.26E- 02 48.7 LYM107 1263 2.1 B 0.09 8 6.41E- 02 57.9 LYM219 13331. 1 D 7.09 6 7.41E- 02 47.6 LYM180 1344 1.5 B 0.16 2 6.47E- 02 162.6 LYM188 13244. 7 D 6.69 8.77E- 02 39.1 LYM227 1454 2.5 B 0.07 1 7.28E- 02 15.4 CONTR OL D 4.80 9 0 LYM52 1289 4.8 B 0.11 1 7.53E- 02 79.6 LYM189 13315. 2 E 0.66 2 3.29E- 03 29.1 LYM117 1362 4.7 B 0.08 2 7.84E- 02 33 2016213786 11 Aug 2016 394 Gene name Event I D Mea n P value % incr. vs. cent. Gene name Event I D Mea n P value % incr. vs. cent. LYM274 13413. 4 E 0.64 6 1.08E- 02 26.1 LYM248 1350 1.6 B 0.07 7 8.28E- 02 24.4 LYM189 13315. 1 E 0.64 1 1.59E- 02 25 CONTR OL B 0.06 2 0 LYM219 13332. 9 E 0.61 3 4.07E- 02 19.6 LYM107 1263 1.1 C 0.83 1 0.00E +00 94.2 LYM161 13233. 6 E 0.60 2 7.90E- 02 17.4 LYM120 1338 2.3 C 1.03 8 0.00E +00 142.4 LYM32 13964. 1 E 0.6 7.97E- 02 17 LYM157 1334 1.3 C 1.14 1 0.00E +00 166.5 CONTR OL E 0.51 3 0 LYM157 1334 1.4 C 0.91 8 0.00E +00 114.5 LYM219 13332. 9 F 7.58 6 1.00E- 06 29 LYM213 1284 2.8 C 1.03 5 0.00E +00 141.7 LYM32 13964. 1 F 6.96 2 7.00E- 06 18.4 LYM52 1289 4.7 C 0.8 0.00E +00 86.9 LYM240 12682. 1 F 6.84 3 3.90E- 05 16.4 LYM213 1284 2.9 C 0.76 2 1.00E- 06 77.9 LYM74 13954. 1 F 7.08 5 4.60E- 05 20.5 LYM120 1338 2.2 C 0.82 8 6.00E- 06 93.3 LYM79 13134. 1 F 7.2 1.08E- 03 22.5 LYM248 1350 3.5 C 0.74 1 6.00E- 06 73 LYM274 13413. 4 F 7.26 2 1.40E- 03 23.5 LYM52 1289 5.7 C 0.72 4 2.50E- 05 69.1 LYM79 13132. 2 F 6.66 2 1.94E- 03 13.3 LYM213 1284 1.6 C 0.7 3.20E- 05 63.5 LYM189 13315. 2 F 7.59 1 1.99E- 03 29.1 LYM120 1338 2.1 C 0.69 5 6.10E- 05 62.3 LYM234 14092. 5 F 7.11 7 2.84E- 03 21.1 LYM180 1344 1.7 C 0.76 3 8.30E- 05 78.3 LYM189 13315. 1 F 7.39 6 2.91E- 03 25.8 LYM180 1344 2.7 C 0.67 5 1.83E- 04 57.6 LYM74 13954. 2 F 7.08 9 5.06E- 03 20.6 LYM79 1313 1.5 C 0.68 2.64E- 04 58.9 LYM161 13233. 6 F 6.97 8 1.61E- 02 18.7 LYM157 1334 1.1 C 0.66 6 5.55E- 04 55.6 LYM161 13233. 5 F 6.50 2 2.85E- 02 10.6 LYM117 1362 1.8 C 0.65 9 8.30E- 04 53.8 LYM122 13711. 3 F 6.64 3 3.74E- 02 13 LYM79 1313 1.6 C 0.65 9 1.51E- 03 53.9 LYM240 12683. 5 F 6.97 8 4.00E- 02 18.7 LYM52 1289 4.8 C 0.67 1.78E- 03 56.5 LYM79 13134. 3 F 6.40 3 5.79E- 02 8.9 LYM52 1289 1.8 c 0.62 4 1.88E- 03 45.8 LYM274 13415. 2 F 6.39 6.01E- 02 8.7 LYM227 1454 2.3 c 0.64 7 2.21E- 03 51.2 LYM245 13061. 8 F 6.36 6 7.89E- 02 8.3 LYM157 1334 2.4 c 0.61 6 4.48E- 03 43.8 LYM217 13181. 6 F 6.76 6 8.26E- 02 15.1 LYM79 1313 2.6 c 0.60 5 4.76E- 03 41.3 CONTR OL F 5.87 9 0 LYM120 1338 2.8 c 0.60 7 5.79E- 03 41.7 LYM189 13315. G 1.28 1.90E- 167.8 LYM180 1344 c 0.61 8.13E- 42.7 2016213786 11 Aug 2016 395 Gene name Event I D Mea n P value % incr. vs. cent. Gene name Event I D Mea n P value % incr. vs. cent. 2 4 05 1.5 1 03 LYM217 13183. 2 G 0.97 3 4.10E- 05 103 LYM117 1362 2.6 C 0.59 3 8.16E- 03 38.5 LYM74 13954. 2 G 0.93 1 6.30E- 05 94.1 LYM248 1350 1.6 c 0.60 4 8.30E- 03 41.1 LYM234 14092. 5 G 1.20 4 1.92E- 04 151.1 LYM213 1284 1.5 c 0.59 4 9.39E- 03 38.7 LYM122 13711. 3 G 1.15 9 3.08E- 04 141.7 LYM227 1454 4.2 c 0.59 3 1.48E- 02 38.6 LYM240 12683. 5 G 1.04 2 7.28E- 04 117.2 LYM107 1263 1.2 c 0.58 8 1.80E- 02 37.4 LYM79 13134. 3 G 0.80 8 1.09E- 03 68.5 LYM117 1362 2.5 c 0.60 4 1.90E- 02 41 LYM245 13061. 8 G 1.27 1 1.20E- 03 165.1 LYM107 1263 3.4 c 0.56 4 2.80E- 02 31.8 LYM79 13132. 2 G 1.32 1.33E- 03 175.3 LYM52 1289 4.6 c 0.54 8 4.99E- 02 27.9 LYM234 14093. 2 G 0.94 3 1.41E- 03 96.7 LYM79 1313 4.7 c 0.53 6 7.39E- 02 25.2 LYM74 13954. 1 G 1.31 3 1.81E- 03 173.7 CONTR OL c 0.42 8 0 LYM217 13186. 1 G 0.91 1 1.88E- 03 90.1 LYM157 1334 1.4 D 8.10 1 0.00E +00 121.4 LYM32 13963. 1 G 0.66 5 2.56E- 03 38.7 LYM213 1284 2.9 D 6.77 7 1.47E- 04 85.2 LYM161 13233. 6 G 1.06 4 2.90E- 03 121.9 LYM213 1284 1.6 D 6.03 9 2.00E- 04 65 LYM217 13182. 1 G 1.08 3 3.10E- 03 125.8 LYM52 1289 4.7 D 7.31 4 8.85E- 04 99.9 LYM219 13332. 9 G 1.06 3 4.10E- 03 121.8 LYM117 1362 2.6 D 5.11 3 1.50E- 03 39.7 LYM161 13233. 5 G 1.09 9 4.42E- 03 129.2 LYM107 1263 1.1 D 7.34 6 1.55E- 03 100.8 LYM274 13415. 2 G 1.15 4.92E- 03 139.8 LYM180 1344 2.7 D 6.26 6 1.64E- 03 71.2 LYM274 13413. 4 G 0.89 9 6.80E- 03 87.4 LYM120 1338 2.1 D 6.10 3 2.38E- 03 66.8 LYM189 13315. 1 G 1.43 7 7.49E- 03 199.8 LYM157 1334 1.3 D 9.88 6 2.61E- 03 170.2 LYM189 13311. 2 G 1.02 9 7.55E- 03 114.6 LYM52 1289 1.8 D 5.27 9 3.81E- 03 44.3 LYM32 13964. 1 G 0.84 4 7.69E- 03 76 LYM248 1350 3.5 D 6.50 1 4.31E- 03 77.7 LYM79 13134. 1 G 0.99 1.05E- 02 106.5 LYM107 1263 3.4 D 5.08 1 6.28E- 03 38.9 LYM234 14091. 1 G 0.91 9 1.09E- 02 91.6 LYM79 1313 2.6 D 5.27 2 7.18E- 03 44.1 LYM188 13244. 4 G 1.04 9 1.17E- 02 118.7 LYM79 1313 4.7 D 4.84 4 7.92E- 03 32.4 LYM217 13181. 9 G 0.77 5 1.18E- 02 61.6 LYM79 1313 1.5 D 5.96 1 1.41E- 02 62.9 LYM240 12683. 9 G 0.57 9 1.27E- 02 20.7 LYM52 1289 5.7 D 6.30 2 1.43E- 02 72.2 2016213786 11 Aug 2016 396 Gene name Event I D Mea n P value % incr. vs. cent. Gene name Event I D Mea n P value % incr. vs. cent. LYM189 13311. 3 G 0.98 1.37E- 02 104.4 LYM157 1334 1.1 D 6.12 7 1.48E- 02 67.4 LYM278 13364. 5 G 0.57 4 1.37E- 02 19.7 LYM213 1284 2.8 D 9.74 5 1.57E- 02 166.3 LYM240 12682. 1 G 1.13 2 1.51E- 02 136.1 LYM157 1334 2.4 D 5.41 8 1.58E- 02 48.1 LYM79 13133. 3 G 0.97 4 1.51E- 02 103.1 LYM120 1338 2.8 D 5.23 3 2.06E- 02 43 LYM234 14092. 8 G 1.15 2.17E- 02 139.7 LYM120 1338 2.3 D 9.17 2 3.14E- 02 150.7 LYM188 13244. 6 G 0.58 2.18E- 02 20.9 LYM213 1284 1.5 D 5.04 4 3.32E- 02 37.9 LYM79 13134. 2 G 0.62 2 2.53E- 02 29.6 LYM117 1362 1.8 D 5.51 3 4.02E- 02 50.7 LYM32 13963. 4 G 0.96 7 2.55E- 02 101.8 LYM120 1338 2.2 D 7.20 7 4.05E- 02 97 LYM79 13133. 2 G 0.95 2.59E- 02 98 LYM79 1313 3.6 D 4.40 4 4.15E- 02 20.4 LYM189 13314. 5 G 0.60 4 2.68E- 02 26 LYM52 1289 4.6 D 4.63 7 4.35E- 02 26.7 LYM161 13234. 6 G 0.98 9 2.76E- 02 106.3 LYM248 1350 1.6 D 5.17 8 5.20E- 02 41.5 LYM74 13952. 2 G 0.83 7 3.56E- 02 74.5 LYM180 1344 1.5 D 5.62 1 5.27E- 02 53.6 LYM189 13314. 4 G 0.80 3 3.63E- 02 67.4 LYM180 1344 1.7 D 6.61 6 5.74E- 02 80.8 LYM274 13413. 1 G 0.82 3 4.32E- 02 71.6 LYM79 1313 1.6 D 5.67 2 6.56E- 02 55 LYM79 13131. 1 G 0.94 1 5.88E- 02 96.2 LYM227 1454 2.3 D 5.39 8 8.39E- 02 47.5 LYM188 13244. 7 G 0.74 1 6.09E- 02 54.5 CONTR OL D 3.65 9 0 LYM234 14092. 1 G 0.61 6 6.23E- 02 28.6 LYM157 1334 1.3 E 0.56 3 8.32E- 03 39.2 LYM219 13331. 1 G 0.77 8 8.27E- 02 62.3 LYM248 1350 3.5 E 0.54 4 1.60E- 02 34.6 CONTR OL G 0.48 0 LYM248 1350 1.6 E 0.53 1 2.70E- 02 31.5 LYM122 13711. 3 H 0.12 1 0.00E +00 155.6 LYM120 1338 2.2 E 0.52 2 4.43E- 02 29.2 LYM161 13233. 6 H 0.11 2 0.00E +00 136 LYM120 1338 2.3 E 0.52 3 6.14E- 02 29.4 LYM161 13233. 5 H 0.11 0.00E +00 133.1 LYM107 1263 1.1 E 0.51 1 6.15E- 02 26.4 LYM161 13234. 6 H 0.10 5 0.00E +00 122 LYM120 1338 2.8 E 0.51 1 6.32E- 02 26.4 LYM188 13244. 4 H 0.10 5 0.00E +00 121.6 LYM52 1289 1.8 E 0.49 8 9.65E- 02 23.4 LYM189 13315. 1 H 0.14 6 0.00E +00 207.9 CONTR OL E 0.40 4 0 LYM189 13315. 2 H 0.13 3 0.00E +00 181.1 LYM107 1263 1.1 F 6.51 7 0.00E +00 32.4 LYM189 13311. H 0.10 0.00E 123.6 LYM157 1334 F 6.66 0.00E 35.4 2016213786 11 Aug 2016 397 Gene name Event I D Mea n P value % incr. vs. cent. Gene name Event I D Mea n P value % incr. vs. cent. 2 6 +00 1.4 3 +00 LYM189 13311. 3 H 0.09 9 0.00E +00 109.8 LYM79 1313 1.5 F 6.65 8 2.30E- 05 35.3 LYM217 13182. 1 H 0.11 7 0.00E +00 146.7 LYM79 1313 2.6 F 6.26 9 6.80E- 05 27.4 LYM217 13183. 2 H 0.09 6 0.00E +00 102.8 LYM248 1350 3.5 F 6.84 9 7.40E- 05 39.1 LYM217 13186. 1 H 0.09 0.00E +00 91 LYM107 1263 3.4 F 6.42 1.94E- 04 30.4 LYM219 13332. 9 H 0.11 0.00E +00 132.5 LYM248 1350 1.6 F 6.55 2.54E- 04 33.1 LYM234 14092. 5 H 0.12 3 0.00E +00 160.3 LYM213 1284 2.8 F 7.02 9 2.62E- 04 42.8 LYM234 14092. 8 H 0.11 9 0.00E +00 151.6 LYM180 1344 2.7 F 6.27 4 3.41E- 04 27.5 LYM234 14093. 2 H 0.10 1 0.00E +00 113.6 LYM213 1284 2.9 F 6.02 8 4.41E- 04 22.4 LYM234 14091. 1 H 0.09 4 0.00E +00 98.2 LYM213 1284 1.6 F 5.83 6 5.41E- 04 18.6 LYM240 12683. 5 H 0.10 9 0.00E +00 130.7 LYM120 1338 2.2 F 6.34 5 1.79E- 03 28.9 LYM240 12682. 1 H 0.10 9 0.00E +00 130 LYM157 1334 1.1 F 5.67 7 2.64E- 03 15.3 LYM245 13061. 8 H 0.12 8 0.00E +00 170.9 LYM157 1334 1.3 F 6.75 2 3.09E- 03 37.2 LYM274 13415. 2 H 0.11 9 0.00E +00 152.5 LYM180 1344 1.7 F 5.93 5 3.68E- 03 20.6 LYM274 13413. 4 H 0.09 5 0.00E +00 101.8 LYM180 1344 1.5 F 6.07 1 4.41E- 03 23.3 LYM274 13413. 1 H 0.08 7 0.00E +00 84.2 LYM52 1289 4.7 F 6.00 8 5.17E- 03 22.1 LYM32 13963. 4 H 0.10 2 0.00E +00 116.1 LYM120 1338 2.3 F 6.67 4 8.09E- 03 35.6 LYM32 13964. 1 H 0.08 9 0.00E +00 87.8 LYM52 1289 1.8 F 5.77 4 9.79E- 03 17.3 LYM74 13954. 1 H 0.12 8 0.00E +00 171.4 LYM79 1313 4.7 F 5.60 1 1.44E- 02 13.8 LYM74 13954. 2 H 0.09 3 O.OOE +00 96.9 LYM227 1454 2.3 F 5.91 1.57E- 02 20.1 LYM79 13132. 2 H 0.13 4 O.OOE +00 183.6 LYM79 1313 3.6 F 5.77 8 2.12E- 02 17.4 LYM79 13133. 3 H 0.10 1 O.OOE +00 114.2 LYM107 1263 1.2 F 5.76 4 2.69E- 02 17.1 LYM79 13134. 1 H 0.1 O.OOE +00 111.5 LYM120 1338 2.1 F 5.44 8 2.96E- 02 10.7 LYM79 13133. 2 H 0.09 7 O.OOE +00 104.7 LYM117 1362 1.8 F 5.54 1 3.11E- 02 12.6 LYM79 13134. 3 H 0.08 2 O.OOE +00 73.1 LYM117 1362 2.6 F 5.57 8 3.16E- 02 13.3 LYM189 13314. 4 H 0.08 3 l.OOE- 06 75.5 LYM157 1334 2.4 F 5.90 6 4.04E- 02 20 LYM74 13952. 2 H 0.08 5 l.OOE- 06 80.6 LYM52 1289 4.6 F 5.68 6 5.87E- 02 15.5 2016213786 11 Aug 2016 398 Gene name Event I D Mea n P value % incr. vs. cent. Gene name Event I D Mea n P value % incr. vs. cent. LYM79 13131. 1 H 0.09 7 1.00E- 06 104.4 LYM157 1334 1.1 F 5.64 7 6.06E- 02 14.7 LYM219 13331. 1 H 0.08 2 1.20E- 05 73.8 LYM120 1338 2.8 F 5.59 7 7.48E- 02 13.7 LYM188 13244. 7 H 0.07 9 1.40E- 05 66.2 LYM248 1350 2.7 F 5.61 7 7.50E- 02 14.1 LYM217 13181. 9 H 0.07 1 7.40E- 05 50 CONTR OL F 4.92 3 0 LYM219 13334. 8 H 0.07 5 4.81E- 04 59.2 LYM79 1313 4.7 G 0.78 3 0.00E +00 69 LYM32 13963. 1 H 0.06 4 1.00E- 03 34.7 LYM120 1338 2.8 G 0.93 7 6.00E- 06 102.4 LYM273 13721. 3 H 0.06 7 1.42E- 03 40.7 LYM180 1344 2.6 G 0.70 8 1.72E- 04 52.9 LYM189 13314. 5 H 0.06 3 1.80E- 03 33.5 LYM79 1313 2.6 G 0.63 5 2.20E- 04 37.1 LYM234 14092. 1 H 0.06 4 2.49E- 03 34.5 LYM248 1350 2.6 G 0.6 3.71E- 04 29.4 LYM217 13181. 6 H 0.06 7 2.63E- 03 41 LYM227 1454 4.2 G 0.61 2 4.69E- 04 32 LYM188 13244. 6 H 0.06 2 3.19E- 03 30.8 LYM107 1263 3.4 G 0.69 5 6.12E- 04 50.1 LYM219 13334. 7 H 0.06 5 6.05E- 03 37.1 LYM120 1338 2.1 G 1.05 6 8.03E- 04 128 LYM79 13134. 2 H 0.06 1 6.73E- 03 28.6 LYM227 1454 2.1 G 0.62 5 8.16E- 04 34.9 LYM240 12683. 9 H 0.05 9 1.03E- 02 25.6 LYM117 1362 2.6 G 0.67 8 8.66E- 04 46.3 LYM122 13713. 4 H 0.06 1 1.40E- 02 29.1 LYM157 1334 1.1 G 1.03 8 1.08E- 03 124.2 LYM278 13364. 5 H 0.05 8 2.02E- 02 23.2 LYM157 1334 1.4 G 0.73 7 1.15E- 03 59.1 LYM274 13413. 3 H 0.06 2.07E- 02 27.2 LYM157 1334 1.3 G 1.52 8 1.56E- 03 229.9 LYM240 12684. 8 H 0.05 9 5.27E- 02 24.1 LYM120 1338 2.2 G 1.05 7 1.65E- 03 128.2 CONTR OL H 0.04 7 0 LYM107 1263 1.1 G 1.08 5 2.28E- 03 134.2 LYM1 11603. 2 A 0.00 6 2.00E- 06 74.1 LYM227 1454 1.5 G 0.61 2.98E- 03 31.8 LYM1 11601. 1 A 0.00 7 1.20E- 05 83.9 LYM120 1338 2.4 G 0.61 4 4.29E- 03 32.6 LYM132 12275. 3 A 0.00 7 1.63E- 04 96.5 LYM213 1284 2.8 G 1.20 5 4.34E- 03 160.1 LYM178 12164. 2 A 0.00 6 2.14E- 03 58 LYM248 1350 3.5 G 0.75 1 4.94E- 03 62.2 LYM132 12271. 4 A 0.00 7 3.64E- 03 97.2 LYM180 1344 2.7 G 0.83 9 5.84E- 03 81.2 LYM1 11604. 4 A 0.00 5 3.68E- 03 29.4 LYM52 1289 5.7 G 1.04 4 6.49E- 03 125.4 LYM268 12483. 2 A 0.00 8 6.62E- 03 111.2 LYM157 1334 2.4 G 0.60 9 6.86E- 03 31.5 LYM5 12432. A 0.00 6.64E- 28.7 LYM180 1344 G 1.02 7.31E- 121.8 2016213786 11 Aug 2016 399 Gene name Event I D Mea n P value % incr. vs. cent. Gene name Event I D Mea n P value % incr. vs. cent. 2 5 03 1.5 1 03 LYM178 12164. 3 A 0.01 1 1.01E- 02 206.3 LYM213 1284 1.8 G 0.73 2 7.99E- 03 58 LYM134 12314. 2 A 0.00 6 1.05E- 02 77.6 LYM120 1338 2.3 G 1.09 9 8.19E- 03 137.3 LYM268 12482. 3 A 0.00 6 1.08E- 02 58.7 LYM52 1289 4.7 G 1.15 3 8.28E- 03 148.8 LYM129 12571. 3 A 0.00 6 1.11E- 02 54.5 LYM213 1284 2.9 G 1.14 3 8.30E- 03 146.8 LYM178 12163. 3 A 0.01 1 1.16E- 02 202.1 LYM79 1313 1.6 G 1.11 8.39E- 03 139.7 LYM1 11602. 6 A 0.01 1 1.60E- 02 197.2 LYM180 1344 1.7 G 1.22 4 1.13E- 02 164.3 LYM1 11602. 1 A 0.00 5 1.79E- 02 46.2 LYM157 1334 1.1 G 0.52 7 1.68E- 02 13.9 LYM268 12482. 1 A 0.00 7 2.35E- 02 97.9 LYM227 1454 2.5 G 0.56 9 1.84E- 02 22.7 LYM132 12276. 1 A 0.00 9 2.60E- 02 146.9 LYM52 1289 4.6 G 0.52 5 1.93E- 02 13.4 LYM129 12572. 2 A 0.00 5 2.65E- 02 46.2 LYM52 1289 1.8 G 0.67 1 2.02E- 02 44.8 LYM5 12432. 1 A 0.00 6 4.79E- 02 70.6 LYM117 1362 1.8 G 0.57 2.22E- 02 23 LYM6 11735. 1 A 0.00 6 5.37E- 02 58 LYM213 1284 1.6 G 0.78 2 2.30E- 02 68.9 LYM132 12273. 2 A 0.00 5 5.62E- 02 44.1 LYM107 1263 2.1 G 0.64 8 2.97E- 02 39.9 LYM268 12483. 4 A 0.00 6 6.34E- 02 65 LYM117 1362 3.9 G 0.67 7 4.19E- 02 46 LYM6 11736. 1 A 0.00 6 6.64E- 02 71.3 LYM117 1362 4.7 G 0.69 5 5.21E- 02 49.9 LYM6 11733. 2 A 0.00 4 6.75E- 02 13.3 LYM117 1362 2.5 G 0.63 4 5.88E- 02 36.9 LYM6 11735. 2 A 0.00 5 6.93E- 02 49 LYM52 1289 4.8 G 0.73 6.31E- 02 57.5 LYM134 12313. 2 A 0.01 1 7.63E- 02 216.1 LYM79 1313 1.5 G 0.65 4 7.90E- 02 41.2 LYM129 12573. 5 A 0.00 7 7.95E- 02 102.8 CONTR OL G 0.46 3 0 CONTR OL A 0.00 4 0 LYM107 1263 1.1 H 0.10 7 0.00E +00 141.1 LYM132 12275. 3 B 0.13 4 1.00E- 06 86.1 LYM120 1338 2.3 H 0.11 1 0.00E +00 148.8 LYM1 11603. 2 B 0.12 4 3.20E- 05 72.1 LYM120 1338 2.2 H 0.10 7 0.00E +00 139.8 LYM1 11601. 1 B 0.12 3 4.10E- 05 71.4 LYM120 1338 2.1 H 0.10 2 0.00E +00 129.7 LYM132 12271. 4 B 0.12 4 1.69E- 04 71.8 LYM120 1338 2.8 H 0.09 4 0.00E +00 111.3 LYM268 12483. 2 B 0.14 2 8.85E- 04 96.8 LYM157 1334 1.3 H 0.14 6 0.00E +00 228.5 LYM178 12164. 2 B 0.11 1 2.98E- 03 54.4 LYM157 1334 1.1 H 0.09 6 0.00E +00 117 2016213786 11 Aug 2016 400 Gene name Event I D Mea n P value % incr. vs. cent. Gene name Event I D Mea n P value % incr. vs. cent. LYM5 12432. 2 B 0.09 6.77E- 03 25.1 LYM180 1344 1.7 H 0.11 4 0.00E +00 157.5 LYM134 12314. 2 B 0.13 8 7.76E- 03 91.2 LYM180 1344 1.5 H 0.09 7 0.00E +00 119.2 LYM129 12571. 3 B 0.11 9.48E- 03 52.8 LYM213 1284 2.8 H 0.11 4 0.00E +00 157 LYM1 11602. 6 B 0.21 4 9.84E- 03 197.7 LYM213 1284 2.9 H 0.10 7 0.00E +00 141.1 LYM268 12482. 3 B 0.12 4 1.45E- 02 71.8 LYM52 1289 4.7 H 0.11 7 0.00E +00 162.5 LYM268 12482. 1 B 0.12 9 1.64E- 02 78.6 LYM52 1289 5.7 H 0.10 5 0.00E +00 136 LYM129 12572. 2 B 0.10 1 1.69E- 02 40.1 LYM79 1313 1.6 H 0.10 8 0.00E +00 142.5 LYM129 12573. 3 B 0.08 7 1.94E- 02 21 LYM180 1344 2.7 H 0.08 1.00E- 06 79.4 LYM6 11735. 2 B 0.13 2.15E- 02 80.5 LYM157 1334 1.4 H 0.07 7 3.00E- 06 73.4 LYM178 12164. 3 B 0.21 5 2.21E- 02 199.1 LYM213 1284 1.6 H 0.07 7 1.70E- 05 74.3 LYM178 12163. 3 B 0.22 7 2.30E- 02 214.8 LYM79 1313 4.7 H 0.07 6.90E- 05 57.7 LYM5 12432. 1 B 0.11 6 2.54E- 02 60.7 LYM52 1289 4.8 H 0.07 5 1.89E- 04 67.6 LYM6 11735. 1 B 0.10 7 2.65E- 02 48.9 LYM227 1454 4.2 H 0.06 7 4.24E- 04 49.8 LYM132 12276. 1 B 0.18 2.72E- 02 150.1 LYM107 1263 3.4 H 0.06 6 5.81E- 04 48.6 LYM134 12313. 2 B 0.22 9 3.20E- 02 217.6 LYM117 1362 2.6 H 0.06 6 5.92E- 04 49 LYM268 12483. 4 B 0.12 8 4.11E- 02 77.8 LYM248 1350 3.5 H 0.06 7 7.50E- 04 50.7 LYM134 12312. 4 B 0.09 6 6.12E- 02 33.5 LYM213 1284 1.8 H 0.06 7 7.87E- 04 50.6 LYM129 12573. 5 B 0.14 4 6.28E- 02 99.7 LYM52 1289 1.8 H 0.06 7 9.77E- 04 49.6 LYM6 11736. 1 B 0.13 7.91E- 02 80.6 LYM117 1362 2.5 H 0.06 7 9.85E- 04 51.7 LYM1 11604. 4 B 0.08 3 9.90E- 02 16 LYM180 1344 2.6 H 0.06 5 1.09E- 03 45.8 CONTR OL B 0.07 2 0 LYM117 1362 3.9 H 0.06 4 3.89E- 03 44.7 LYM1 11602. 6 C 0.96 5 0.00E +00 91.4 LYM79 1313 2.6 H 0.06 2 5.30E- 03 38.5 LYM1 11601. 1 C 0.83 8.30E- 05 64.7 LYM107 1263 2.1 H 0.06 3 5.57E- 03 41.7 LYM268 12483. 2 C 0.80 3 1.01E- 04 59.3 LYM120 1338 2.4 H 0.06 1 5.57E- 03 38.2 LYM132 12276. 1 C 0.93 6 1.06E- 04 85.8 LYM117 1362 4.7 H 0.06 4 5.91E- 03 43.9 LYM178 12164. 3 C 0.83 1 1.49E- 04 64.9 LYM248 1350 2.6 H 0.06 9.80E- 03 35.3 LYM129 12571. C 0.79 1.72E- 57.5 LYM213 1284 H 0.06 1.07E- 39 2016213786 11 Aug 2016 401 Gene name Event I D Mea n P value % incr. vs. cent. Gene name Event I D Mea n P value % incr. vs. cent. 3 4 04 1.5 2 02 LYM129 12573. 5 C 0.83 1.82E- 04 64.6 LYM227 1454 2.1 H 0.05 9 1.46E- 02 33.2 LYM268 12482. 3 c 0.75 2 4.97E- 04 49.2 LYM157 1334 2.4 H 0.06 1.46E- 02 34.4 LYM268 12483. 4 c 0.75 2 8.08E- 04 49.2 LYM117 1362 1.8 H 0.06 1.51E- 02 34.5 LYM178 12163. 3 c 0.84 9 8.09E- 04 68.5 LYM79 1313 1.5 H 0.06 2.75E- 02 35.8 LYM5 12435. 1 c 0.77 1 9.77E- 04 52.9 LYM227 1454 1.5 H 0.05 7 3.75E- 02 28.4 LYM134 12314. 2 c 0.73 3 1.55E- 03 45.5 CONTR OL H 0.04 4 0 LYM178 12164. 2 c 0.67 9 7.95E- 03 34.7 LYM79 1313 1.6 A 0.00 4 9.00E- 06 63 LYM134 12313. 2 c 0.73 9 8.31E-03 46.6 LYM79 1313 3.6 A 0.00 4 1.55E- 03 61 LYM132 12275. 3 c 0.67 5 1.62E- 02 34 LYM79 1313 1.5 A 0.00 4 3.66E- 02 40 LYM1 11603. 2 c 0.68 3 3.61E- 02 35.6 LYM79 1313 2.6 A 0.00 4 3.91E- 02 47 CONTR OL c 0.50 4 0 LYM227 1454 4.2 A 0.00 4 5.01E- 02 72 LYM1 11602. 6 D 8.10 9 7.70E- 05 79.7 LYM79 1313 4.7 A 0.00 3 5.24E- 02 39 LYM268 12483. 2 D 6.77 9 9.34E- 04 50.3 LYM227 1454 2.5 A 0.00 3 7.71E- 02 35 LYM268 12482. 3 D 6.31 8 9.47E- 04 40 CONTR OL A 0.00 3 0 LYM129 12571. 3 D 6.58 7 1.03E- 03 46 LYM79 1313 3.6 B 0.08 9 3.95E- 03 23.5 LYM134 12314. 2 D 6.14 6 2.72E- 03 36.2 LYM227 1454 4.2 B 0.10 1 1.09E- 02 40.9 LYM1 11601. 1 D 7.07 4 6.19E- 03 56.8 LYM227 1454 2.1 B 0.08 2 5.43E- 02 14.7 LYM268 12483. 4 D 6.37 5 1.10E-02 41.3 LYM79 1313 1.5 B 0.09 3 7.88E- 02 28.9 LYM178 12164. 2 D 5.68 1 1.80E- 02 25.9 LYM79 1313 2.6 B 0.09 5 8.38E- 02 32.4 LYM129 12573. 5 D 7.10 5 1.84E- 02 57.5 LYM227 1454 2.5 B 0.08 5 9.81E- 02 18.4 LYM178 12164. 3 D 6.94 1 1.87E- 02 53.8 CONTR OL B 0.07 2 0 LYM132 12276. 1 D 7.98 5 3.78E- 02 77 LYM79 1313 4.7 C 0.66 5 5.00E- 05 49.9 LYM5 12435. 1 D 6.43 3 4.32E- 02 42.6 LYM79 1313 2.6 C 0.68 3 1.75E- 04 53.9 LYM132 12275. 3 D 5.76 9 5.38E- 02 27.9 LYM227 1454 4.2 C 0.60 6 2.21E- 03 36.6 LYM178 12163. 3 D 7.17 1 6.48E- 02 59 LYM79 1313 3.6 C 0.61 4 5.09E- 03 38.3 CONTR OL D 4.51 1 0 LYM79 1313 1.5 C 0.60 6 6.01E- 03 36.5 2016213786 11 Aug 2016 402 Gene name Event I D Mea n P value % incr. vs. cent. Gene name Event I D Mea n P value % incr. vs. cent. LYM178 12164. 3 E 0.61 8 6.14E- 04 35.8 LYM227 1454 2.5 C 0.58 9 9.41E- 03 32.9 LYM5 12435. 1 E 0.6 6.85E- 04 31.8 LYM79 1313 1.6 c 0.55 9 2.18E- 02 26 LYM134 12314. 2 E 0.59 8 1.04E- 03 31.5 LYM227 1454 2.3 c 0.57 6 2.31E- 02 29.9 LYM268 12482. 3 E 0.59 1.49E- 03 29.6 CONTR OL c 0.44 4 0 LYM129 12571. 3 E 0.59 6 1.76E- 03 31 LYM79 1313 4.7 D 5.69 8 4.00E- 06 47.8 LYM132 12276. 1 E 0.59 5 2.11E- 03 30.8 LYM79 1313 1.6 D 5.05 1 2.55E- 04 31 LYM1 11602. 6 E 0.58 4.57E- 03 27.6 LYM227 1454 4.2 D 5.17 6 7.52E- 03 34.3 LYM132 12275. 3 E 0.58 7 9.38E- 03 29 LYM79 1313 1.5 D 5.50 4 5.52E- 02 42.8 LYM178 12164. 2 E 0.55 7 1.30E- 02 22.5 LYM79 1313 2.6 D 5.91 1 5.61E- 02 53.3 LYM268 12483. 4 E 0.53 9 4.86E- 02 18.5 LYM227 1454 2.5 D 5.15 9 6.06E- 02 33.8 LYM178 12163. 3 E 0.55 3 5.88E- 02 21.4 LYM79 1313 3.6 D 5.42 9 8.59E- 02 40.9 LYM1 11601. 1 E 0.54 3 6.29E- 02 19.2 CONTR OL D 3.85 5 0 LYM129 12573. 5 E 0.54 8 7.27E- 02 20.4 LYM79 1313 4.7 F 6.19 1 5.25E- 04 18 LYM5 12432. 1 E 0.53 2 7.47E- 02 16.9 LYM79 1313 2.6 F 6.15 8 6.45E- 03 17.4 LYM129 12572. 2 E 0.52 7.70E- 02 14.4 LYM79 1313 1.5 F 6.28 6 7.80E- 03 19.8 CONTR OL E 0.45 5 0 LYM227 1454 2.3 F 5.86 3 7.80E- 02 11.7 LYM268 12482. 3 F 6.79 7 1.32E- 04 22.4 CONTR OL F 5.24 7 0 LYM5 12435. 1 F 6.56 6 5.75E- 04 18.2 LYM79 1313 1.6 G 0.75 6 8.17E- 03 48 LYM134 12314. 2 F 6.85 8 2.92E- 03 23.5 LYM227 1454 4.2 G 0.57 5 3.56E- 02 12.6 LYM132 12276. 1 F 6.96 8 4.43E- 03 25.4 CONTR OL G 0.51 1 0 LYM129 12571. 3 F 6.61 4 1.13E- 02 19.1 LYM79 1313 1.6 H 0.07 5 1.40E- 05 50.2 LYM178 12164. 3 F 6.68 5 1.23E- 02 20.3 LYM227 1454 4.2 H 0.06 2 1.36E- 02 24.5 LYM268 12483. 2 F 6.47 7 1.34E- 02 16.6 LYM79 1313 3.6 H 0.06 2 1.76E- 02 25.2 LYM268 12483. 4 F 6.49 4 1.43E- 02 16.9 LYM79 1313 1.5 H 0.06 4 2.54E- 02 28.1 LYM1 11602. 6 F 6.60 7 1.52E- 02 18.9 LYM227 1454 2.5 H 0.06 1 3.57E- 02 22.1 LYM1 11601. 1 F 6.59 5 2.97E- 02 18.7 LYM79 1313 4.7 H 0.05 9 6.68E- 02 19.2 LYM178 12164. F 6.10 4.81E- 9.9 LYM79 1313 H 0.05 8.94E- 18.9 2016213786 11 Aug 2016 403 Gene name Event I D Mea n P value % incr. vs. cent. Gene name Event I D Mea n P value % incr. vs. cent. 2 6 02 2.6 9 02 LYM132 12275. 3 F 6.54 6 7.02E- 02 17.8 CONTR OL H 0.05 0 LYM129 12573. 5 F 6.54 4 9.24E- 02 17.8 CONTR OL F 5.55 5 0 LYM1 11601. 1 G 0.75 8.00E- 06 56.3 LYM132 12271. 4 G 0.76 1.00E- 05 58.3 LYM132 12275. 3 G 0.84 1 4.10E- 05 75.2 LYM268 12482. 1 G 0.73 8 2.75E- 04 53.6 LYM178 12164. 3 G 1.03 1 1.85E- 03 114.7 LYM1 11603. 2 G 0.66 5 1.89E- 03 38.5 LYM134 12314. 2 G 0.75 9 2.43E- 03 58.1 LYM1 11602. 6 G 1.00 2 3.24E- 03 108.6 LYM178 12164. 2 G 0.61 5 7.36E- 03 28 LYM178 12163. 3 G 0.92 9 1.03E- 02 93.6 LYM132 12276. 1 G 0.83 3 1.10E-02 73.5 LYM6 11736. 1 G 0.75 1.25E- 02 56.2 LYM129 12573. 5 G 0.78 6 2.28E- 02 63.6 LYM268 12483. 2 G 0.72 8 2.44E- 02 51.6 LYM6 11735. 2 G 0.59 4 2.79E- 02 23.7 LYM268 12482. 3 G 0.63 3.55E- 02 31.3 LYM5 12432. 1 G 0.74 1 3.96E- 02 54.3 LYM129 12572. 2 G 0.59 8 4.01E- 02 24.5 LYM1 11602. 1 G 0.58 8 5.84E- 02 22.4 LYM268 12483. 4 G 0.70 8 6.03E- 02 47.5 LYM134 12313. 2 G 0.96 8 6.92E- 02 101.5 CONTR OL G 0.48 0 LYM136 13423. 1 A 0.00 6 4.00E- 06 156.7 LYM160 1347 2.1 A 0.01 0.00E +00 138.8 2016213786 11 Aug 2016 404 Gene name Event I D Mea n P value % incr. vs. cent. Gene name Event I D Mea n P value % incr. vs. cent. LYMl 11601. 1 A 0.00 4 2.49E- 04 69.1 LYM136 1342 3.4 A 0.00 9 1.48E- 04 118.5 LYM136 13421. 5 A 0.00 6 1.77E- 03 129.9 LYM293 1339 1.2 A 0.00 7 5.51E- 03 57.6 LYM84 13404. 4 A 0.00 4 3.79E- 03 81.4 LYM293 1339 1.4 A 0.00 9 8.63E- 03 106 LYMl 11602. 6 A 0.00 7 5.63E- 03 182.5 LYM136 1342 1.7 A 0.00 8 1.58E- 02 94 LYMl 11603. 2 A 0.00 5 7.42E- 03 125.8 LYM136 1342 1.8 A 0.00 8 2.02E- 02 92.2 LYM84 13401. 2 A 0.00 5 1.15E- 02 91.8 LYMl 60 1347 1.1 A 0.00 8 3.06E- 02 95.2 LYM84 13403. 1 A 0.00 7 1.33E- 02 170.1 LYM84 1340 3.1 A 0.00 8 3.34E- 02 90.4 LYM84 13403. 3 A 0.00 5 1.48E- 02 99 LYMl 60 1347 2.2 A 0.00 7 3.80E- 02 78.5 LYM136 13421. 6 A 0.00 5 2.79E- 02 116.5 LYM84 1340 3.3 A 0.01 2 6.33E- 02 186 LYM136 13421. 8 A 0.00 7 2.82E- 02 189.7 LYM293 1339 2.2 A 0.00 7 6.99E- 02 70.1 LYM84 13403. 2 A 0.00 6 2.92E- 02 156.7 LYM84 1340 1.2 A 0.00 7 7.32E- 02 66.6 LYMl 11602. 1 A 0.00 4 3.31E- 02 70.1 LYM293 1339 1.9 A 0.00 7 7.86E- 02 67.8 LYM136 13423. 2 A 0.00 4 3.85E- 02 79.4 LYM136 1342 1.5 A 0.00 8 8.34E- 02 99.4 LYMl 11604. 4 A 0.00 3 5.00E- 02 39.2 LYMl 60 1347 1.4 A 0.00 6 9.24E- 02 31.3 CONTR OL _ A 0.00 2 _ 0 CONTR OL _ A 0.00 4 _ 0 LYM84 13401. 2 B 0.09 3 1.52E- 03 80.5 LYMl 60 1347 2.1 B 0.21 8 5.01E- 03 128.9 LYMl 11601. 1 B 0.09 4.19E- 03 75.6 LYM136 1342 3.4 B 0.19 7.33E- 03 100 LYM136 13423. 1 B 0.12 5 5.82E- 03 143.9 LYM136 1342 1.8 B 0.17 3 1.03E- 02 81.6 LYM84 13403. 3 B 0.1 6.00E- 03 95.1 LYM293 1339 1.2 B 0.13 8 1.09E- 02 44.7 LYM136 13421. 5 B 0.10 3 8.84E- 03 100 LYM84 1340 1.2 B 0.13 8 1.59E- 02 44.7 LYM136 13421. 6 B 0.12 3 9.57E- 03 139 LYM136 1342 1.7 B 0.15 3 2.38E- 02 60.5 LYMl 11602. 6 B 0.13 1.32E- 02 153.7 LYM84 1340 3.3 B 0.27 5 3.54E- 02 189.5 LYM136 13423. 2 B 0.08 8 1.41E- 02 70.7 LYMl 60 1347 2.2 B 0.15 5 6.63E- 02 63.2 LYM136 13421. 8 B 0.15 5 2.23E- 02 202.4 LYM293 1339 1.4 B 0.19 3 7.66E- 02 102.6 LYM84 13403. 2 B 0.15 5 2.32E- 02 202.4 LYM136 1342 1.5 B 0.18 8.25E- 02 89.5 LYM84 13404. 4 B 0.09 5 2.70E- 02 85.4 LYMl 60 1347 1.1 B 0.18 8.25E- 02 89.5 LYMl 11603. B 0.10 2.70E- 109.8 LYM84 1340 B 0.19 8.89E- 105.3 2016213786 11 Aug 2016 405 Gene name Event I D Mea n P value % incr. vs. cent. Gene name Event I D Mea n P value % incr. vs. cent. 2 8 02 3.1 5 02 LYMl 11604. 4 B 0.07 3 3.33E- 02 41.5 CONTR OL _ B 0.09 5 _ 0 LYM1 11602. 1 B 0.08 8 3.79E- 02 70.7 LYM136 1342 1.5 G 1.16 1.40E- 05 113.3 LYM84 13403. 1 B 0.15 5.94E- 02 192.7 LYMl 60 1347 2.1 G 1.07 3 1.70E- 05 97.2 CONTR OL _ B 0.05 1 _ 0 LYMl 60 1347 1.1 G 0.97 3 1.00E- 04 78.9 LYMl 11601. 1 G 0.75 7.00E- 06 88.7 LYM84 1340 3.1 G 0.91 5 1.04E- 04 68.3 LYM84 13403. 1 G 0.75 8.00E- 06 88.7 LYM136 1342 3.4 G 1.08 1.69E- 03 98.6 LYM84 13404. 4 G 0.64 9.30E- 05 61 LYM136 1342 1.8 G 1.03 5 3.80E- 03 90.3 LYMl 11603. 2 G 0.63 5 7.21E- 04 59.7 LYM293 1339 1.4 G 1.19 3 5.56E- 03 119.3 LYM136 13421. 6 G 0.68 8 1.51E- 03 73 LYM84 1340 1.2 G 0.83 7.52E- 03 52.6 LYM84 13401. 2 G 0.68 8 2.17E- 03 73 LYM84 1340 3.3 G 1.41 8 7.77E- 03 160.7 LYMl 11602. 6 G 0.78 3 3.89E- 03 96.9 LYMl 60 1347 2.2 G 0.76 1.94E- 02 39.8 LYM136 13423. 1 G 0.83 4.81E- 03 108.8 LYM136 1342 1.7 G 0.88 2.80E- 02 61.8 LYM84 13403. 3 G 0.72 4.83E- 03 81.1 LYM293 1339 1.2 G 0.74 4.83E- 02 36.1 LYM136 13421. 5 G 0.62 6.93E- 03 56 LYM293 1339 2.2 G 0.88 5 4.98E- 02 62.8 LYM84 13403. 2 G 0.78 5 1.19E- 02 97.5 LYM136 1342 3.2 G 0.79 5 8.04E- 02 46.2 LYM136 13421. 8 G 0.87 8 1.65E- 02 120.8 LYM293 1339 1.9 G 0.81 3 8.66E- 02 49.4 LYM136 13423. 2 G 0.61 2.94E- 02 53.5 LYMl 60 1347 1.4 G 0.72 5 9.93E- 02 33.3 LYMl 11604. 4 G 0.51 5 2.96E- 02 29.6 CONTR OL _ G 0.54 4 _ 0 CONTR OL _ G 0.39 8 _ 0 LYM136 1342 1.5 H 0.12 2 0.00E +00 119 LYM136 13423. 1 H 0.08 1 0.00E +00 101.6 LYMl 60 1347 2.1 H 0.11 8 0.00E +00 110.6 LYM84 13403. 1 H 0.07 6 0.00E +00 88.3 LYM84 1340 3.3 H 0.15 1.00E- 06 168.9 LYMl 11602. 6 H 0.07 7 1.00E- 06 91.4 LYM136 1342 3.4 H 0.11 6 3.00E- 06 108.4 LYMl 11601. 1 H 0.06 8 2.00E- 06 70.4 LYM293 1339 1.4 H 0.12 1 6.00E- 06 116.8 LYM84 13403. 2 H 0.08 3 2.00E- 06 107 LYM136 1342 1.8 H 0.10 6 7.20E- 05 90.5 LYM136 13421. 8 H 0.08 7 4.00E- 06 116.3 LYMl 60 1347 1.1 H 0.09 7 1.50E- 04 74.2 LYM136 13421. 6 H 0.06 8 7.00E- 06 68.1 LYM84 1340 3.1 H 0.08 9 8.80E- 04 59.1 2016213786 11 Aug 2016 406 Gene name Event I D Mea n P value % incr. vs. cent. Gene name Event I D Mea n P value % incr. vs. cent. LYM84 13403. 3 H 0.07 9.00E- 06 74.3 LYM136 1342 1.7 H 0.09 4 1.79E- 03 68.6 LYM84 13401. 2 H 0.06 5 2.60E- 05 62.6 LYM84 1340 1.2 H 0.08 6 3.12E- 03 54.6 LYM136 13421. 5 H 0.06 6 2.80E- 05 65 LYM293 1339 2.2 H 0.09 3 3.73E- 03 66.4 LYM1 11603. 2 H 0.06 2 3.00E- 05 54.9 LYM160 1347 2.2 H 0.08 5 5.45E- 03 51.8 LYM84 13404. 4 H 0.06 7.80E- 05 48.6 LYM293 1339 1.9 H 0.08 4 2.09E- 02 50.7 LYM136 13423. 2 H 0.06 1 1.90E- 03 51.8 LYM293 1339 1.2 H 0.07 8 2.83E- 02 40.1 LYM1 11604. 4 H 0.05 4 4.45E- 03 35.4 LYM136 1342 3.2 H 0.08 1 3.88E- 02 44.5 LYM1 11602. 1 H 0.05 3 1.86E- 02 31.5 LYM160 1347 1.4 H 0.07 5 6.82E- 02 34.5 CONTR OL _ H 0.04 _ 0 CONTR OL _ H 0.05 6 _ 0 LYM84 13403. 2 C 1.02 7 1.40E- 05 80.2 LYM136 1342 1.5 C 0.90 8 0.00E +00 100.7 LYM136 13423. 1 C 1.02 3 1.50E- 05 79.7 LYM136 1342 1.8 C 0.87 3 0.00E +00 93.1 LYM136 13421. 8 C 1.02 8 7.30E- 05 80.6 LYM293 1339 1.2 C 0.79 2 0.00E +00 75.2 LYM84 13403. 1 C 0.89 3 1.60E- 04 56.8 LYM160 1347 2.1 C 0.72 1 1.00E- 06 59.5 LYM84 13403. 3 C 0.86 7 6.59E- 04 52.3 LYM84 1340 3.3 C 1.08 9 1.00E- 06 140.8 LYM136 13421. 6 C 0.85 3 2.33E- 03 49.8 LYM136 1342 3.2 C 0.83 1 3.00E- 06 83.8 LYM136 13423. 2 C 0.86 4 3.27E- 03 51.7 LYM293 1339 1.4 C 1.07 1 3.00E- 06 136.8 LYM1 11603. 2 C 0.81 7 3.91E- 03 43.4 LYM160 1347 1.1 C 0.77 2 3.10E- 05 70.6 LYM84 13401. 2 C 0.80 4 4.08E- 03 41.2 LYM84 1340 1.2 C 0.69 2 3.40E- 05 52.9 LYM1 11602. 6 C 0.86 2 5.42E- 03 51.3 LYM136 1342 3.4 C 0.77 7 4.90E- 05 71.7 LYM1 11601. 1 C 0.78 9 1.01E- 02 38.6 LYM160 1347 2.2 C 0.67 2 1.41E- 04 48.7 LYM1 11604. 4 C 0.82 3 1.54E- 02 44.5 LYM84 1340 3.1 C 0.64 6 2.21E- 04 42.9 LYM84 13404. 4 C 0.73 4 2.94E- 02 28.8 LYM293 1339 1.9 C 0.76 3 2.73E- 04 68.7 LYM1 11602. 1 C 0.72 7 4.75E- 02 27.6 LYM136 1342 1.7 C 0.72 7 8.57E- 04 60.7 LYM136 13421. 5 C 0.71 5 7.12E- 02 25.5 LYM293 1339 2.2 C 0.66 8 1.97E- 02 47.8 CONTR OL _ C 0.57 _ 0 CONTR OL _ C 0.45 2 _ 0 LYM1 11604. 4 E 0.58 3 3.46E- 03 26.5 LYM84 1340 3.3 E 0.55 9 5.55E- 02 23 LYM84 13403. E 0.57 1.03E- 24.6 CONTR E 0.45 0 2016213786 11 Aug 2016 407 Gene name Event I D Mea n P value % incr. vs. cent. Gene name Event I D Mea n P value % incr. vs. cent. 2 4 02 OL 4 LYM136 13421. 8 E 0.55 1 1.41E- 02 19.7 LYM136 1342 1.8 D 7.68 5 9.00E- 05 87.2 LYM84 13403. 3 E 0.56 2 1.74E- 02 21.9 LYM136 1342 1.5 D 8.41 8 1.06E- 04 105 LYM1 11601. 1 E 0.54 9 2.97E- 02 19.1 LYM160 1347 2.1 D 6.28 5.37E- 04 52.9 LYM84 13401. 2 E 0.54 3 4.13E- 02 17.9 LYM293 1339 1.2 D 6.82 3 2.80E- 03 66.1 LYM84 13403. 1 E 0.53 5 4.77E- 02 16.1 LYM84 1340 3.1 D 5.88 8.55E- 03 43.2 LYM84 13404. 4 E 0.52 8 5.27E- 02 14.6 LYM84 1340 1.2 D 6.16 5 9.88E- 03 50.1 LYM136 13423. 2 E 0.54 3 5.95E- 02 18 LYM136 1342 3.2 D 7.68 5 1.61E- 02 87.2 LYM1 11602. 1 E 0.52 5 6.56E- 02 13.9 LYM160 1347 1.1 D 6.81 8 1.69E- 02 66 CONTR OL _ E 0.46 1 _ 0 LYM84 1340 3.3 D 9.51 8 2.04E- 02 131.8 LYM136 13423. 1 D 8.86 3 8.70E- 05 75.8 LYM136 1342 3.4 D 7.01 5 2.44E- 02 70.8 LYM84 13403. 1 D 7.74 8 3.02E- 03 53.7 LYM160 1347 2.2 D 5.75 8 2.55E- 02 40.2 LYM84 13403. 2 D 8.73 8 5.76E- 03 73.4 LYM293 1339 1.4 D 9.49 2.56E- 02 131.1 LYM84 13403. 3 D 7.59 8 8.31E-03 50.7 LYM293 1339 1.9 D 6.7 4.90E- 02 63.2 LYM84 13401. 2 D 7.03 8 9.19E- 03 39.6 LYM136 1342 1.7 D 6.53 3 5.11E- 02 59.1 LYM84 13404. 4 D 6.51 5 1.63E- 02 29.3 CONTR OL _ D 4.10 6 _ 0 LYM1 11603. 2 D 7.22 3 2.00E- 02 43.3 LYM136 1342 1.5 F 6.76 5 1.52E- 03 21.7 LYM136 13421. 8 D 8.99 3 2.33E- 02 78.4 LYM136 1342 3.2 F 6.73 2.68E- 03 21.1 LYM1 11601. 1 D 6.88 8 2.44E- 02 36.7 LYM136 1342 1.8 F 6.94 3 3.01E- 03 24.9 LYM136 13421. 6 D 7.33 5 3.72E- 02 45.5 LYM84 1340 1.2 F 6.2 9.41E- 03 11.5 LYM136 13423. 2 D 7.40 5 4.76E- 02 46.9 LYM136 1342 1.7 F 6.38 3.57E- 02 14.8 LYM1 11602. 6 D 7.60 5 4.83E- 02 50.9 LYM293 1339 1.9 F 6.22 3 4.78E- 02 11.9 LYM1 11602. 1 D 6.27 8 4.96E- 02 24.6 LYM84 1340 3.3 F 6.78 3 5.99E- 02 22 CONTR OL _ D 5.04 _ 0 LYM293 1339 1.2 F 6.20 8 7.14E- 02 11.7 LYM136 13421. 8 F 7.01 8 1.11E- 04 27.1 LYM160 1347 1.1 F 6.12 5 9.99E- 02 10.2 LYM84 13404. 4 F 6.47 8 3.96E- 04 17.3 CONTR OL _ F 5.55 9 _ 0 LYM136 13423. 1 F 6.81 7.54E- 04 23.3 2016213786 11 Aug 2016 408 Gene name Event I D Mea n P value % incr. vs. cont. Gene name Event I D Mea n P value % incr. vs. cont. LYM1 11601. 1 F 6.77 5 2.36E- 03 22.7 LYM84 13403. 3 F 6.76 5 3.61E- 03 22.5 LYM84 13403. 1 F 6.53 4.49E- 03 18.3 LYM84 13403. 2 F 6.90 3 5.58E- 03 25 LYM1 11603. 2 F 6.81 3 6.13E- 03 23.4 LYM136 13423. 2 F 6.79 7.54E- 03 23 LYM84 13401. 2 F 6.63 3 1.04E- 02 20.1 LYM1 11602. 1 F 6.27 5 1.24E- 02 13.7 LYM136 13421. 6 F 6.11 3 1.93E- 02 10.7 LYM1 11604. 4 F 6.70 8 2.78E- 02 21.5 CONTR OL — F 5.52 1 _ 0 Table 34. Results of the tissue culture experiments. Provided are the measured values of each tested parameter [parameters (ID.) A-F according to the parameters described in Table 33 above] in plants expressing the indicated polynucleotides. “Ev” = event; “P” = P-value; “Mean ” = the average of measured parameter across replicates. % incr. vs. cont. = percentage of increase versus control (as compared to control). 5

Table 35

Measured parameters at the tissue culture assay (T1 experiment) for transformed 10 agriculture improving trait genes

Tested Parameters ID Dry Weight (gr) A Fresh Weight (gr) B RGR Of Root Coverage C Roots Coverage TP3 (cm2) D RGR Of Roots Length E Roots Length TP3 (cm) F Leaf Area TP3 (cm) G RGR Of Leaf Area H Leaf Area TP1 (cm) I Roots Length TP1 (cm) J

Table 35: Provided are the identification (ID) letters of each of the Tested Parameters. TP3 = Time point 3; RGR - relative growth rate. TP1 = Time point 1. 2016213786 11 Aug 2016 409

Results obtained in a T1 experiment at the tissue culture assay

Table 36 Gene name ID Mean P value % incr. vs. cent Gene name ID Mean P value % incr. vs. cent LYM161 A 0.014 1.24E- 03 90.4 LYM240 H 0.078 2.23E-02 31.2 LYM219 A 0.01 2.07E- 03 28.3 LYM228 H 0.077 2.59E-02 29.8 LYM83 A 0.01 1.93E- 02 30.6 LYM189 H 0.076 3.81E-02 28 LYM278 A 0.009 3.67E- 02 25.9 LYM184 H 0.082 4.23E-02 37.8 LYM204 A 0.01 5.84E- 02 36.3 LYM248 H 0.076 6.24E-02 27.1 LYM155 A 0.013 6.05E- 02 70.7 CONTROL H 0.06 _ 0 LYM221 A 0.009 9.70E- 02 22.9 LYM117 A 0.009 5.26E-04 65.7 CONTROL 0.007 0 LYM146 A 0.01 1.17E-02 81.5 LYM161 B 0.282 9.40E- 05 75.5 LYM144 A 0.007 1.61E-02 34.3 LYM83 B 0.213 3.45E- 03 32.5 LYM93 A 0.008 7.31E-02 43.5 LYM219 B 0.207 2.66E- 02 28.8 LYM123 A 0.006 7.96E-02 19 LYM204 B 0.207 6.73E- 02 28.8 LYM127 A 0.007 9.16E-02 32.1 LYM155 B 0.267 9.60E- 02 66.3 CONTROL A 0.005 _ 0 LYM278 B 0.191 9.94E- 02 18.9 LYM117 B 0.198 7.40E-05 75.7 CONTROL 0.161 0 LYM127 B 0.159 8.58E-04 41.3 LYM221 C 0.468 1.90E- 03 94.9 LYM146 B 0.186 8.64E-03 65.3 LYM155 C 0.468 2.86E- 03 95.2 LYM192 B 0.148 1.44E-02 31.7 LYM161 C 0.484 3.41E- 03 101.5 LYM144 B 0.153 4.48E-02 35.5 LYM188 C 0.4 2.12E- 02 66.5 LYM93 B 0.172 5.30E-02 52.3 LYM144 C 0.355 9.94E- 02 48.1 LYM135 B 0.178 5.72E-02 58 CONTROL 0.24 0 LYM123 B 0.156 5.80E-02 38.4 LYM188 D 3.425 1.59E- 03 67.6 LYM200 B 0.153 6.00E-02 35.5 LYM221 D 3.964 1.79E- 03 94 CONTROL B 0.113 _ 0 LYM155 D 3.85 1.26E- 02 88.4 LYM135 C 0.625 1.90E-05 79.8 LYM144 D 3.038 4.84E- 02 48.6 LYM127 C 0.614 5.30E-05 76.4 LYM161 D 4.023 7.69E- 96.8 LYM146 C 0.553 1.54E-04 58.8 2016213786 11 Aug 2016 410 Gene name ID Mean P value % incr. vs. cent Gene name ID Mean P value % incr. vs. cent 02 CONTROL 2.044 0 LYM117 C 0.537 5.03E-04 54.2 LYM155 E 0.444 9.80E- 03 58.2 LYM154 c 0.56 1.78E-03 60.9 LYM221 E 0.413 2.08E- 02 47 LYM192 c 0.492 3.37E-03 41.5 LYM188 E 0.41 2.14E- 02 46.1 LYM93 c 0.477 8.26E-03 37 LYM161 E 0.412 2.44E- 02 46.6 LYM200 c 0.483 9.48E-03 38.9 LYM144 E 0.405 2.83E- 02 44.2 LYM144 c 0.473 1.14E-02 35.8 CONTROL 0.281 0 LYM123 c 0.473 1.75E-02 35.8 LYM188 F 4.053 6.86E- 04 41.3 LYM273 c 0.473 1.83E-02 35.8 LYM144 F 3.97 2.09E- 03 38.4 CONTROL c 0.348 _ 0 LYM221 F 4.058 3.24E- 03 41.5 LYM192 D 4.217 1.10E-03 42.2 LYM161 F 3.914 2.30E- 02 36.5 LYM93 D 4.075 1.12E-03 37.4 LYM278 F 3.493 5.26E- 02 21.8 LYM144 D 4.057 4.97E-03 36.8 LYM155 F 4.084 5.40E- 02 42.4 LYM117 D 4.4 7.86E-03 48.4 LYM204 F 3.68 6.02E- 02 28.3 LYM146 D 4.555 9.70E-03 53.6 CONTROL 2.868 0 LYM200 D 4.151 3.73E-02 40 LYM83 G 0.883 2.63E- 04 31.7 LYM135 D 5.162 4.62E-02 74 LYM161 G 1.129 1.06E- 03 68.3 LYM127 D 5.078 5.37E-02 71.2 LYM221 G 0.856 4.40E- 03 27.7 LYM123 D 4.062 7.29E-02 37 LYM278 G 0.834 9.29E- 03 24.3 CONTROL D 2.966 _ 0 LYM155 G 1.024 2.05E- 02 52.8 LYM127 E 0.535 9.11E-04 48.7 LYM144 G 0.823 3.31E- 02 22.7 LYM135 E 0.508 2.21E-03 41 LYM204 G 0.789 4.70E- 02 17.6 LYM117 E 0.463 1.53E-02 28.7 CONTROL 0.671 0 LYM93 E 0.448 2.20E-02 24.5 LYM161 H 0.122 4.00E- 06 71.4 LYM192 E 0.444 3.60E-02 23.2 LYM155 H 0.112 2.07E- 04 56.9 LYM154 E 0.456 4.57E-02 26.7 LYM83 H 0.096 7.84E- 03 35.1 CONTROL E 0.36 _ 0 LYM278 H 0.09 3.91E- 02 26.5 LYM93 F 4.431 8.92E-04 21.7 2016213786 11 Aug 2016 411 Gene name ID Mean P value % incr. vs. cent Gene name ID Mean P value % incr. vs. cent LYM221 H 0.089 4.80E- 02 25.3 LYM192 F 4.435 9.73E-03 21.8 LYM144 H 0.088 6.23E- 02 23.8 LYM144 F 4.132 6.49E-02 13.5 CONTROL 0.071 0 LYM123 F 4.108 7.42E-02 12.8 LYM227 A 0.01 8.00E- 05 53.1 LYM135 F 4.683 9.16E-02 28.6 LYM32 A 0.007 1.81E- 03 19.8 CONTROL F 3.641 _ 0 LYM40 A 0.009 1.92E- 03 49.9 LYM127 G 0.72 6.12E-04 22.6 LYM273 A 0.009 2.65E- 03 44.7 LYM117 G 0.904 2.69E-03 53.9 LYM273 A 0.01 3.12E- 03 63.1 LYM192 G 0.701 3.05E-03 19.3 LYM200 A 0.01 8.53E- 03 57.9 LYM135 G 0.885 1.05E-02 50.7 LYM118 A 0.008 2.84E- 02 24.2 LYM146 G 0.854 1.87E-02 45.4 LYM164 A 0.009 3.85E- 02 39.1 LYM144 G 0.693 2.45E-02 18 LYM23 A 0.008 6.86E- 02 32.3 LYM93 G 0.737 9.00E-02 25.4 LYM93 A 0.01 8.67E- 02 61.9 CONTROL G 0.588 _ 0 LYM122 A 0.008 9.35E- 02 28.3 LYM117 H 0.095 1.50E-05 62.9 CONTROL 0.006 0 LYM135 H 0.09 4.07E-04 55.5 LYM227 B 0.248 4.10E- 05 47.9 LYM146 H 0.085 9.67E-04 46.9 LYM40 B 0.216 2.49E- 04 28.6 LYM93 H 0.075 2.94E-02 29.7 LYM273 B 0.231 7.82E- 03 37.8 LYM127 H 0.073 7.67E-02 25.7 LYM200 B 0.251 1.45E- 02 49.8 CONTROL H 0.058 _ 0 LYM146 B 0.229 1.83E- 02 36.6 LYM180 A 0.006 1.39E-04 44.3 LYM273 B 0.249 1.90E- 02 48.6 LYM243 A 0.006 3.56E-03 64.4 LYM164 B 0.222 2.09E- 02 32.2 LYM194 A 0.006 9.85E-03 62.5 LYM154 B 0.216 3.87E- 02 28.8 LYM221 A 0.005 4.06E-02 34.6 LYM122 B 0.189 6.35E- 02 12.9 LYM204 A 0.006 4.55E-02 60.5 LYM135 B 0.197 7.69E- 02 17.4 LYM109 A 0.005 6.49E-02 29.4 CONTROL 0.168 0 LYM233 A 0.007 7.12E-02 70.9 LYM234 C 0.482 5.87E- 02 32.1 CONTROL A 0.004 — 0 2016213786 11 Aug 2016 412 Gene name ID Mean P value % incr. vs. cent Gene name ID Mean P value % incr. vs. cent LYM200 C 0.469 6.18E- 02 28.7 LYM243 B 0.148 1.67E-02 28.8 LYM227 c 0.47 6.80E- 02 28.9 CONTROL B 0.115 _ 0 LYM154 c 0.481 7.23E- 02 31.9 LYM233 C 0.383 4.28E-04 55.4 CONTROL 0.364 0 LYM204 C 0.377 6.67E-04 52.8 LYM200 D 3.874 5.17E- 02 27.9 LYM248 C 0.377 1.32E-03 53.1 CONTROL 3.029 0 LYM194 C 0.366 1.66E-03 48.4 LYM273 G 1.057 1.01E- 04 23 LYM186 C 0.387 1.93E-03 57.1 LYM227 G 1.033 1.50E- 04 20.2 LYM243 C 0.347 4.89E-03 40.9 LYM200 G 1.012 2.71E- 04 17.8 LYM83 C 0.349 5.96E-03 41.5 LYM273 G 1.027 2.79E- 04 19.6 LYM109 C 0.34 1.16E-02 38 LYM154 G 1.022 1.12E- 02 18.9 LYM228 C 0.336 1.95E-02 36.4 LYM164 G 1.027 8.89E- 02 19.5 LYM115 C 0.339 1.96E-02 37.7 LYM146 G 1.063 8.89E- 02 23.7 LYM252 C 0.34 2.33E-02 38 LYM40 G 0.97 9.15E- 02 12.9 CONTROL C 0.246 _ 0 LYM135 G 1.045 9.75E- 02 21.6 LYM243 D 2.941 4.12E-03 38.7 CONTROL 0.859 0 LYM115 D 2.938 6.77E-03 38.6 LYM93 H 0.117 2.44E- 02 29.7 LYM194 D 3.087 8.47E-03 45.6 LYM146 H 0.112 3.08E- 02 24.4 LYM233 D 3.284 1.36E-02 54.9 LYM273 H 0.108 4.22E- 02 20.3 LYM204 D 3.176 2.25E-02 49.8 LYM273 H 0.107 5.78E- 02 19 LYM83 D 2.959 3.59E-02 39.6 LYM154 H 0.108 6.06E- 02 19.8 LYM109 D 2.886 4.28E-02 36.1 LYM164 H 0.108 6.30E- 02 20 LYM248 D 3.188 5.13E-02 50.4 LYM135 H 0.108 7.21E- 02 19.8 CONTROL D 2.12 _ 0 LYM227 H 0.106 7.58E- 02 17.7 LYM248 E 0.416 9.58E-03 27.1 LYM200 H 0.106 7.94E- 02 17.6 LYM204 E 0.389 6.24E-02 19.1 LYM234 H 0.107 8.46E- 02 18.6 LYM233 E 0.39 7.40E-02 19.4 CONTROL 0.09 0 LYM83 E 0.385 8.68E-02 17.7 LYM131 A 0.008 2.70E- 60.5 CONTROL E 0.327 0 2016213786 11 Aug 2016 413 Gene name ID Mean P value % incr. vs. cent Gene name ID Mean P value % incr. vs. cent 02 LYM194 A 0.007 5.17E- 02 36.9 LYM115 F 3.729 2.49E-03 13.6 LYM261 A 0.006 5.62E- 02 29.7 LYM248 F 4.115 5.82E-03 25.3 LYM185 A 0.01 5.77E- 02 99.7 LYM228 F 3.665 2.44E-02 11.6 LYM123 A 0.007 7.73E- 02 39 LYM204 F 3.852 4.19E-02 17.3 LYM192 A 0.006 7.80E- 02 14.4 LYM83 F 3.788 6.51E-02 15.4 CONTROL 0.005 0 LYM233 F 3.97 8.99E-02 20.9 LYM252 B 0.165 5.43E- 03 38.4 CONTROL F 3.284 _ 0 LYM131 B 0.181 2.17E- 02 51.5 LYM233 G 0.768 5.26E-03 41.5 LYM194 B 0.164 3.02E- 02 37.5 LYM194 G 0.73 1.12E-02 34.5 LYM185 B 0.225 3.55E- 02 87.9 LYM228 G 0.597 4.27E-02 9.8 LYM123 B 0.154 4.39E- 02 28.9 LYM243 G 0.676 4.45E-02 24.5 CONTROL 0.12 0 LYM215 G 0.626 6.82E-02 15.4 LYM185 C 0.527 6.00E- 06 97.4 LYM204 G 0.697 8.47E-02 28.3 LYM123 C 0.495 1.50E- 05 85.7 CONTROL G 0.543 _ 0 LYM131 C 0.454 2.90E- 05 70.4 LYM233 H 0.078 1.07E-04 38.3 LYM194 C 0.413 1.09E- 03 54.7 LYM194 H 0.077 4.96E-04 36.3 LYM243 C 0.406 3.94E- 03 52.1 LYM204 H 0.069 2.23E-02 23.5 LYM252 C 0.375 1.15E- 02 40.5 LYM243 H 0.068 2.43E-02 20.9 LYM233 C 0.366 1.81E- 02 37.2 LYM252 H 0.071 2.64E-02 26.5 LYM215 C 0.338 7.24E- 02 26.7 CONTROL H 0.056 _ 0 CONTROL 0.267 0 LYM189 A 0.009 3.27E-04 32.5 LYM131 D 3.668 3.37E- 04 67.4 LYM32 A 0.01 8.84E-03 51.3 LYM215 D 2.788 1.33E- 02 27.2 LYM219 A 0.01 4.76E-02 49.4 LYM194 D 3.34 2.15E- 02 52.4 LYM240 A 0.009 5.15E-02 33.2 LYM123 D 4.004 3.68E- 02 82.7 LYM161 A 0.01 7.76E-02 52 LYM185 D 4.257 5.21E- 02 94.2 CONTROL A 0.007 _ 0 LYM233 D 3.014 6.12E- 37.5 LYM32 B 0.19 9.39E-04 27.5 2016213786 11 Aug 2016 414 Gene name ID Mean P value % incr. vs. cent Gene name ID Mean P value % incr. vs. cent 02 LYM252 D 3.036 7.43E- 02 38.5 LYM249 B 0.225 2.56E-03 51 CONTROL 2.192 0 LYM189 B 0.21 3.29E-02 40.5 LYM131 E 0.469 8.00E- 06 42.8 LYM193 B 0.193 6.69E-02 29.1 LYM185 E 0.47 2.28E- 04 43.1 LYM261 B 0.177 7.40E-02 18.5 LYM123 E 0.448 3.49E- 04 36.4 CONTROL B 0.149 _ 0 LYM194 E 0.411 6.53E- 03 25.3 LYM234 C 0.531 0.00E+00 123.9 LYM243 E 0.407 8.35E- 03 24 LYM249 C 0.539 0.00E+00 127.6 LYM252 E 0.383 7.84E- 02 16.6 LYM219 C 0.517 7.00E-06 118.2 CONTROL 0.328 0 LYM240 C 0.415 2.30E-05 75.1 LYM131 F 4.042 7.90E- 05 32 LYM74 C 0.443 6.30E-05 86.9 LYM243 F 3.668 1.22E- 02 19.8 LYM179 C 0.406 1.06E-04 71.1 LYM215 F 3.383 3.49E- 02 10.5 LYM161 C 0.409 1.34E-04 72.4 LYM194 F 3.635 4.63E- 02 18.8 LYM79 C 0.412 1.71E-04 73.6 LYM123 F 3.912 5.09E- 02 27.8 LYM188 C 0.38 5.35E-04 60.3 LYM185 F 4.091 7.35E- 02 33.7 LYM278 C 0.376 1.23E-03 58.5 CONTROL 3.061 0 LYM261 C 0.369 1.75E-03 55.6 LYM131 G 0.834 1.00E- 06 54 LYM224 C 0.382 3.15E-03 61.3 LYM123 G 0.78 2.30E- 05 44.1 LYM189 C 0.349 5.89E-03 47.3 LYM233 G 0.643 8.49E- 03 18.8 LYM32 C 0.341 2.37E-02 44 LYM252 G 0.713 2.16E- 02 31.8 LYM193 C 0.322 4.86E-02 35.6 LYM243 G 0.656 2.67E- 02 21.2 LYM155 C 0.302 9.72E-02 27.2 LYM192 G 0.669 2.77E- 02 23.5 CONTROL C 0.237 _ 0 LYM261 G 0.637 3.41E- 02 17.7 LYM240 D 3.448 1.00E-06 67.3 LYM194 G 0.715 5.43E- 02 32 LYM188 D 3.137 6.00E-06 52.2 LYM185 G 0.825 5.58E- 02 52.4 LYM179 D 3.35 9.72E-04 62.6 CONTROL 0.541 0 LYM189 D 2.884 1.31E-03 39.9 LYM131 H 0.087 3.00E- 06 53.4 LYM234 D 4.399 4.93E-03 113.5 2016213786 11 Aug 2016 415 Gene name ID Mean P value % incr. vs. cent Gene name ID Mean P value % incr. vs. cent LYM185 H 0.092 1.70E- 05 62.1 LYM249 D 4.486 8.04E-03 117.7 LYM123 H 0.083 3.10E- 05 46.2 LYM74 D 3.651 9.49E-03 77.2 LYM252 H 0.077 2.13E- 03 34.4 LYM261 D 3.07 2.24E-02 49 LYM194 H 0.077 3.63E- 03 34.1 LYM161 D 3.381 2.29E-02 64.1 LYM192 H 0.073 1.17E- 02 27.3 LYM278 D 3.171 2.40E-02 53.9 LYM261 H 0.069 4.77E- 02 20.8 LYM79 D 3.427 3.04E-02 66.3 LYM243 H 0.068 7.19E- 02 18.9 LYM219 D 4.274 7.53E-02 107.4 CONTROL 0.057 0 LYM155 D 2.558 8.03E-02 24.1 LYM245 A 0.008 1.20E- 02 38.7 CONTROL D 2.061 _ 0 LYM228 A 0.008 1.47E- 02 44.3 LYM249 E 0.438 5.00E-06 53.9 LYM240 A 0.008 2.80E- 02 45.2 LYM234 E 0.431 3.10E-05 51.7 LYM260 A 0.007 3.74E- 02 27.4 LYM219 E 0.401 1.65E-03 41.2 LYM189 A 0.007 3.75E- 02 27 LYM224 E 0.397 2.21E-03 39.7 LYM184 A 0.009 5.19E- 02 49.1 LYM179 E 0.378 3.93E-03 33 CONTROL 0.006 0 LYM79 E 0.383 5.24E-03 34.7 LYM245 B 0.16 1.51E- 02 41.9 LYM240 E 0.362 8.54E-03 27.4 LYM260 B 0.15 2.23E- 02 33 LYM74 E 0.373 9.36E-03 31.3 LYM189 B 0.136 4.67E- 02 20.6 LYM189 E 0.352 2.77E-02 23.9 LYM240 B 0.144 5.98E- 02 27.5 LYM261 E 0.35 3.22E-02 23 LYM228 B 0.148 7.33E- 02 31.1 LYM188 E 0.352 3.95E-02 23.9 LYM184 B 0.159 8.46E- 02 41.5 LYM193 E 0.351 5.12E-02 23.4 CONTROL 0.113 0 LYM161 E 0.348 5.53E-02 22.4 LYM184 C 0.46 1.23E- 03 98.6 LYM32 E 0.344 8.20E-02 21 LYM240 C 0.363 6.06E- 03 56.9 LYM251 E 0.338 9.37E-02 18.9 LYM109 C 0.33 2.96E- 02 42.4 CONTROL E 0.284 _ 0 LYM245 C 0.322 5.20E- 02 39.3 LYM74 F 3.635 3.70E-05 18.8 LYM248 C 0.323 5.28E- 02 39.7 LYM249 F 4.232 3.54E-03 38.3 2016213786 11 Aug 2016 416 Gene name ID Mean P value % incr. vs. cent Gene name ID Mean P value % incr. vs. cent LYM189 C 0.318 6.19E- 02 37.2 LYM240 F 3.548 3.55E-03 16 LYM186 c 0.315 6.33E- 02 36 LYM234 F 4.189 3.00E-02 36.9 CONTROL 0.232 0 LYM261 F 3.464 4.23E-02 13.2 LYM109 D 2.67 9.12E- 04 41.4 LYM179 F 3.591 9.25E-02 17.4 LYM186 D 2.588 1.06E- 02 37 CONTROL F 3.06 _ 0 LYM240 D 2.99 1.63E- 02 58.4 LYM240 G 0.919 5.00E-06 57.4 LYM189 D 2.592 1.94E- 02 37.3 LYM249 G 0.849 1.20E-05 45.4 LYM245 D 2.594 4.12E- 02 37.4 LYM278 G 0.879 9.10E-05 50.5 LYM115 D 2.352 4.59E- 02 24.6 LYM261 G 0.799 1.65E-04 36.8 LYM248 D 2.622 7.42E- 02 38.8 LYM224 G 0.739 2.43E-04 26.5 LYM180 D 2.304 7.43E- 02 22 LYM189 G 0.853 1.11E-03 46 CONTROL 1.888 0 LYM161 G 0.913 1.62E-03 56.3 LYM240 E 0.391 1.32E- 02 29.6 LYM79 G 0.915 2.06E-03 56.7 LYM248 E 0.386 2.03E- 02 28.1 LYM188 G 0.747 1.25E-02 27.9 LYM186 E 0.384 2.65E- 02 27.4 LYM219 G 0.841 1.69E-02 44.1 LYM184 E 0.417 5.28E- 02 38.2 LYM74 G 0.762 1.99E-02 30.4 LYM180 E 0.366 6.72E- 02 21.5 LYM179 G 0.795 4.21E-02 36.2 LYM109 E 0.364 7.31E-02 20.8 LYM234 G 0.815 4.73E-02 39.5 CONTROL 0.301 0 CONTROL G 0.584 0 LYM240 F 3.576 2.32E- 03 26.9 LYM161 H 0.097 2.10E-05 62.6 LYM109 F 3.246 1.05E- 02 15.2 LYM240 H 0.094 4.70E-05 57.3 LYM248 F 3.449 1.22E- 02 22.4 LYM79 H 0.095 7.60E-05 59.9 LYM180 F 3.271 3.14E- 02 16 LYM189 H 0.091 1.67E-04 53.1 LYM186 F 3.533 4.22E- 02 25.3 LYM278 H 0.088 4.71E-04 47.7 LYM189 F 3.237 6.97E- 02 14.8 LYM249 H 0.086 7.09E-04 45.4 LYM115 F 3.16 7.89E- 02 12.1 LYM219 H 0.087 1.31E-03 46 CONTROL 2.819 0 LYM234 H 0.086 2.25E-03 44.5 LYM184 G 0.774 3.40E- 36 LYM261 H 0.082 3.68E-03 38.3 2016213786 11 Aug 2016 417 Gene name ID Mean P value % incr. vs. cont Gene name ID Mean P value % incr. vs. cont 05 LYM228 G 0.749 1.29E- 03 31.6 LYM32 H 0.086 4.72E-03 44.3 LYM189 G 0.726 6.50E- 03 27.5 LYM179 H 0.081 1.11E-02 35.5 LYM240 G 0.735 2.55E- 02 29.1 LYM74 H 0.081 1.50E-02 36.7 LYM186 G 0.653 4.33E- 02 14.7 LYM188 H 0.077 2.66E-02 29.3 CONTROL 0.569 0 LYM224 H 0.077 4.09E-02 30.1 CONTROL H 0.059 0 LYM38 B 0.115 13.8 LYM126 B 0.136 34.3 CONTROL B 0.101 0 LYM36 A 0.004 E-4.75 01 6.7 LYM36 I 0.138 E-014.84 7.8 CONTROL A 0.004 0 CONTROL I 0.128 0 LYM36 I 0.09 E-4.34 01 7 LYM36 J 0.693 E-017.20 3.3 CONTROL I 0.084 0 CONTROL J 0.671 0 Table 36. Results of the tissue culture experiments. Provided are the measurec values of each tested parameter [parameters (ID.) A-F according to the parameters described in Table 35 above] in plants expressing the indicated polynucleotides. “Ev” = event; “P” = P-value; “Mean ” = the average of measured parameter across events. % incr. vs. cont. = percentage of increase versus control (as compared to control).

Table 37

Measured parameters at the tissue culture assay low nitrogen (T2 experiment) for 10 transformed agriculture improving trait genes

Tested Parameters ID Dry Weight (gr) G Fresh Weight (gr) H RGR Of Root Coverage I Roots Coverage TP3 (cm2) J RGR Of Roots Length K Roots Length TP3 (cm) L Leaf Area TP3 (cm) M RGR Of Leaf Area N

Table 37: Provided are the identification (ID) letters of each of the Tested Parameters. TP3 - Time Point 3; RGR- Relative Growth Rate plants were grown on low nitrogen as described above. 2016213786 11 Aug 2016 418 Table 38 Results obtained in a T2 experiment at the tissue culture assay low nitrogen

Gene name

Event

I D

Mea n P value % incr . vs. cent

Gene name

Event

I D

Mea n P value % incr . vs. cent LYM17 LYM37 LYM34

CONTR OL LYM37 LYM178

CONTR OL LYM12 LYM37

CONTR OL LYM5 LYM86 LYM82 LYM82 LYM86

CONTR OL LYM268 LYM82 LYM44 LYM6 LYM82 LYM129 LYM86 LYM86 12161 .1 11801 .2 11901 .1 11801 .2 12161 .1 11873 .4 11801 .2 12436 .1 12183 .3 12203 .5 12201 .2 12182 .3 12482 .1 12203 .5 11884 .1 11735 .2 12201 .2 12573 .1 12183 .3 12182 .3 0.006 0.007 0.006 0.004 1.024 1.023 0.652 6.672 6.593 5.425 0.008 0.007 0.011 0.008 0.007 0.004 2.07E- 03 3.50E- 03 3.63E- 03 1.65E- 04 5.17E- 04 5.23E- 03 5.54E- 03 3.89E- 04 5.67E- 04 2.31E- 03 2.64E- 03 2.83E- 03 39.1 60 31.9 56.9

56T 23 21.5 83.5 63 153 77.8 49.9 LYM5 12432 .1 0.007 1.40E- 05 69.3 LYM268 LYM1 LYM178 LYM132 LYM129 LYM1 LYM129 LYM268 LYM178 LYM132

CONTR OL LYM1 LYM5 LYM268 LYM129 12483 .2 11602 .6 12164 .3 12275 .3 12572 .2 11604 .4 12571 .3 12483 .4 12164 .2 12273 .2 11602 .6 12432 .1 12483 .2 12572 .2 0.007 0.009 0.009 0.006 0.006 0.006 0.006 0.008 0.006 0.005 0.004 1.56E- 04 2.16E- 04 3.01E- 03 3.52E- 03 5.24E- 03 5.89E- 03 7.22E- 03 7.89E- 03 8.14E- 03 8.21E- 03 56.6 107. 110. 2 50.6 41.6 39.2 45.2 95.£ 50.6 30.7 0

H

H 0.177 0.142 0.154 0.123 1.00E- 06 1.94E- 04 9.59E- 04 1.86E- 03 103. 6 64 76.8 41.4

H

H 0.115 0.189 0.12 0.102 0.144 0.122 0.132 0.124 8.00E- 06 2.40E- 04 6.61E- 04 6.94E- 04 1.47E- 03 1.54E- 03 1.66E- 03 2.94E- 03 61.6 166 67.8 43.6 101. 5 71.9 85.3 73.7 LYM132 LYM129 LYM6 LYM178

CONTR OL LYM268 LYM5 LYM178 12275 .3 12573 .5 11735 .1 12164 .2 12483 .4 12435 .1 12164 .3

H

H 0.144 2.77E- 03 66.3 0.13 0.118 0.133 0.087 1.459 1.327 1.39 3.59E- 03 8.04E- 03 9.56E- 03 0.00E+ 00 5.00E- 06 2.60E- 05 50.2 36 53.6 94.9 77.2 85.7 2016213786 11 Aug 2016 419 Gene name Event I D Mea n P value % incr . vs. cent Gene name Event I D Mea n P value % incr . vs. cent LYM5 12436 .1 H 0.155 6.44E- 03 118. 2 LYM129 12571 .3 I 1.264 3.90E- 05 68.7 LYM129 12572 .2 H 0.121 7.61E- 03 69.9 LYM129 12573 .5 I 1.215 4.60E- 05 62.3 LYM82 12204 .6 H 0.091 9.35E- 03 27.4 LYM268 12483 .2 I 1.195 7.50E- 05 59.5 LYM5 12435 .1 H 0.104 9.36E- 03 45.6 LYM268 12482 .3 I 1.16 3.42E- 04 54.9 LYM8 11984 .1 H 0.15 9.54E- 03 110. 2 LYM134 12314 .2 I 1.199 4.26E- 04 60.1 CONTR OL H 0.071 0 LYM1 11603 .2 I 1.094 1.02E- 03 46.1 LYM268 12483 .4 I 1.515 0.00E+ 00 124. 3 LYM5 12432 .2 I 1.082 2.26E- 03 44.5 LYM82 12203 .2 I 1.459 0.00E+ 00 116 LYM268 12482 .1 I 1.23 4.74E- 03 64.3 LYM82 12203 .5 I 1.419 8.00E- 06 110. 1 LYM1 11602 .6 I 1.073 6.12E- 03 43.2 LYM8 11984 .1 I 1.336 1.10E-05 97.9 LYM132 12276 .1 I 1.134 7.20E- 03 51.5 LYM44 11882 .1 I 1.135 2.40E- 05 68.1 CONTR OL I 0.749 0 LYM5 12436 .1 I 1.264 3.40E- 05 87.2 LYM268 12483 .4 J 12.19 3.00E- 05 90.2 LYM86 12183 .3 I 1.056 1.39E- 04 56.3 LYM5 12435 .1 J 10.94 5 1.14E- 03 70.8 LYM86 12182 .3 I 1.219 1.86E- 04 80.5 LYM129 12571 .3 J 10.37 5 1.25E- 03 61.9 LYM5 12436 .2 I 1.072 2.95E- 04 58.7 LYM129 12573 .5 J 10.09 3 2.32E- 03 57.5 LYM82 12201 .2 I 0.986 3.76E- 04 46 LYM268 12483 .2 J 9.908 2.57E- 03 54.6 LYM44 11884 .3 I 1.094 5.32E- 04 62 LYM268 12482 .3 J 9.59 4.95E- 03 49.6 LYM44 11885 .4 I 1.249 1.21E- 03 85 CONTR OL J 6.409 0 LYM268 12484 .2 I 1.147 1.40E- 03 69.9 LYM129 12571 .3 K 0.76 6.00E- 05 41.4 LYM8 11982 .7 I 0.958 1.62E- 03 41.9 LYM5 12435 .1 K 0.754 6.90E- 05 40.3 LYM8 11983 .1 I 1.007 1.85E- 03 49.1 CONTR OL K 0.538 0 LYM129 12573 .1 I 0.935 2.77E- 03 38.4 LYM129 12571 .3 L 7.821 3.52E- 04 23.6 LYM129 12573 .3 I 0.901 2.85E- 03 33.4 LYM5 12435 .1 L 7.76 5.05E- 04 22.6 LYM268 12482 .1 I 0.992 3.37E- 03 46.9 LYM268 12483 .4 L 7.69 6.12E- 04 21.5 LYM6 11734 .3 I 1.105 5.28E- 03 63.6 CONTR OL L 6.328 0 LYM5 12435 I 1.047 6.27E- 55.1 LYM5 12432 M 0.837 3.00E- 67.1 2016213786 11 Aug 2016 420 Gene name Event I D Mea n P value % incr . vs. cent Gene name Event I D Mea n P value % incr . vs. cent .1 03 .1 06 LYM129 12572 .2 I 0.97 7.93E- 03 43.6 LYM129 12571 .3 M 0.732 2.50E- 05 46.1 CONTR OL I 0.675 0 LYM132 12273 .2 M 0.685 8.40E- 05 36.7 LYM82 12203 .2 J 12.32 8 1.84E- 03 118. 3 LYM1 11604 .4 M 0.692 1.78E- 04 38.1 LYM129 12573 .3 J 7.459 3.21E- 03 32.1 LYM129 12573 .5 M 0.797 3.26E- 04 59.1 LYM268 12483 .4 J 12.72 6 6.83E- 03 125. 4 LYM178 12163 .3 M 0.668 6.70E- 04 33.4 LYM82 12201 .2 J 8.641 8.55E- 03 53 LYM1 11602 .6 M 0.95 7.84E- 04 89.7 CONTR OL J 5.647 0 LYM5 12435 .1 M 0.756 8.12E- 04 51.1 LYM82 12203 .2 K 0.636 1.22E- 03 30 LYM132 12275 .3 M 0.727 1.36E- 03 45.3 LYM5 12435 .1 K 0.624 1.73E- 03 27.8 LYM1 11602 .1 M 0.676 1.74E- 03 35.1 LYM86 12182 .3 K 0.622 2.13E- 03 27.3 LYM268 12483 .4 M 0.889 2.41E- 03 77.5 LYM268 12483 .4 K 0.628 3.66E- 03 28.5 LYM178 12164 .3 M 0.93 2.60E- 03 85.7 LYM44 11884 .3 K 0.614 5.55E- 03 25.7 LYM178 12164 .2 M 0.732 4.37E- 03 46.3 CONTR OL K 0.489 0 LYM129 12572 .2 M 0.7 5.37E- 03 39.9 LYM82 12203 .2 L 7.098 1.50E- 05 35.2 LYM134 12314 .2 M 0.746 5.84E- 03 48.9 LYM86 12182 .3 L 6.996 2.30E- 05 33.3 LYM1 11603 .2 M 0.78 9.55E- 03 55.8 LYM268 12483 .4 L 7.232 2.69E- 04 37.8 CONTR OL M 0.501 0 LYM5 12435 .1 L 6.758 3.03E- 04 28.7 LYM1 11602 .6 N 0.098 0.00E+ 00 96 LYM82 12203 .5 L 7.346 4.61E- 04 39.9 LYM178 12164 .3 N 0.094 0.00E+ 00 87 LYM86 12183 .3 L 6.532 8.44E- 04 24.4 LYM268 12483 .4 N 0.092 0.00E+ 00 83.5 LYM5 12432 .1 L 6.265 1.21E- 03 19.3 LYM5 12432 .1 N 0.083 1.00E- 06 65.1 LYM5 12436 .1 L 6.713 1.40E- 03 27.9 LYM5 12435 .1 N 0.083 6.00E- 06 65.5 LYM44 11884 .3 L 6.768 1.41E- 03 28.9 LYM129 12573 .5 N 0.08 7.00E- 06 60.5 LYM268 12484 .2 L 6.748 3.26E- 03 28.5 LYM1 11603 .2 N 0.082 1.10E-05 64.2 LYM44 11885 .4 L 6.724 3.68E- 03 28.1 LYM129 12571 .3 N 0.076 2.30E- 05 52.5 LYM8 11983 .1 L 6.614 5.58E- 03 26 LYM178 12164 .2 N 0.078 3.10E- 05 55.3 2016213786 11 Aug 2016 421 Gene name Event I D Mea n P value % incr . vs. cent Gene name Event I D Mea n P value % incr . vs. cent LYM5 12436 .2 L 6.52 6.08E- 03 24.2 LYM132 12275 .3 N 0.073 7.30E- 05 45.8 LYM86 12181 .3 L 6.239 6.93E- 03 18.8 LYM132 12273 .2 N 0.071 8.20E- 05 41.5 LYM8 11984 .1 L 6.951 8.05E- 03 32.4 LYM132 12276 .1 N 0.076 1.27E- 04 52.1 CONTR OL L 5.25 0 LYM1 11604 .4 N 0.071 1.52E- 04 41 LYM82 12203 .2 M 0.836 8.30E- 05 110. 7 LYM5 12432 .2 N 0.077 1.63E- 04 53.8 LYM129 12572 .2 M 0.675 4.28E- 04 69.9 LYM268 12482 .1 N 0.082 1.98E- 04 63 LYM268 12482 .1 M 0.63 6.12E- 04 58.6 LYM129 12572 .2 N 0.072 2.38E- 04 44.1 LYM82 12203 .5 M 0.836 9.33E- 04 110. 6 LYM134 12313 .2 N 0.084 2.41E- 04 67.5 LYM86 12183 .3 M 0.684 1.14E- 03 72.2 LYM134 12314 .2 N 0.073 6.27E- 04 45.5 LYM82 12204 .6 M 0.491 1.31E- 03 23.6 LYM268 12483 .2 N 0.077 1.02E- 03 52.9 LYM82 12201 .2 M 0.787 1.98E- 03 98.1 LYM1 11602 .1 N 0.068 1.34E- 03 36.8 LYM268 12483 .4 M 0.825 2.72E- 03 107. 9 LYM132 12271 .4 N 0.075 2.22E- 03 49.5 LYM5 12436 .1 M 0.776 3.22E- 03 95.3 LYM178 12163 .3 N 0.064 7.09E- 03 26.9 LYM268 12484 .2 M 0.743 4.16E- 03 87.2 LYM1 11601 .1 N 0.067 8.58E- 03 34.4 LYM8 11984 .1 M 0.716 4.66E- 03 80.3 CONTR OL N 0.05 0 LYM8 11982 .7 M 0.565 8.97E- 03 42.3 LYM5 12435 .1 M 0.674 9.05E- 03 69.7 LYM86 12182 .3 M 0.719 9.47E- 03 81.2 LYM268 12481 .1 M 0.627 9.53E- 03 58 CONTR OL M 0.397 0 LYM268 12483 .4 N 0.085 0.00E+ 00 112. 8 LYM82 12203 .2 N 0.088 0.00E+ 00 119. 9 LYM82 12203 .5 N 0.087 0.00E+ 00 116. 8 LYM5 12436 .1 N 0.078 1.00E- 06 95.5 LYM82 12201 .2 N 0.074 2.00E- 06 85 LYM8 11984 N 0.075 3.00E- 87 2016213786 11 Aug 2016 422 Gene name Event I D Mea n P value % incr . vs. cent Gene name Event I D Mea n P value % incr . vs. cent .1 06 LYM86 12183 .3 N 0.072 3.00E- 06 80.7 LYM129 12573 .1 N 0.073 1.00E- 05 82.5 LYM268 12484 .2 N 0.073 1.20E- 05 82.9 LYM86 12182 .3 N 0.074 2.00E- 05 85.7 LYM5 12435 .1 N 0.072 2.60E- 05 80.5 LYM268 12482 .1 N 0.066 6.90E- 05 63.7 LYM129 12572 .2 N 0.068 8.00E- 05 71.2 LYM268 12481 .3 N 0.066 8.40E- 05 64 LYM44 11884 .3 N 0.067 9.10E- 05 68 LYM268 12481 .1 N 0.062 4.98E- 04 54.5 LYM44 11885 .4 N 0.068 5.74E- 04 70.9 LYM5 12436 .2 N 0.062 9.56E- 04 55.4 LYM8 11982 .7 N 0.059 1.14E- 03 47 LYM44 11884 .1 N 0.057 2.22E- 03 42 LYM8 11982 .4 N 0.057 2.75E- 03 42.3 LYM82 12201 .1 N 0.056 5.28E- 03 39 LYM86 12183 .1 N 0.056 7.02E- 03 40.5 LYM44 11885 .3 N 0.059 7.80E- 03 46.7 LYM44 11882 .1 N 0.056 8.64E- 03 40.3 CONTR OL N 0.04 0 LYM136 13423 .2 H 0.006 2.00E- 06 107. 3 LYM136 13423 .2 N 0.085 0.00E+ 00 82.6 LYM136 13421 .8 G 0.005 8.66E- 04 75.6 LYM136 13421 .8 N 0.082 0.00E+ 00 75.9 LYM84 13404 .4 G 0.007 2.84E- 03 113. 8 LYM84 13404 .4 N 0.092 0.00E+ 00 96.7 LYM136 13421 .6 G 0.006 2.89E- 03 94.3 LYM84 13401 .2 N 0.088 0.00E+ 00 88 LYM1 11601 .1 G 0.005 5.24E- 03 61 LYM1 11601 .1 N 0.081 1.00E- 06 73.2 2016213786 11 Aug 2016 423 Gene name Event I D Mea n P value % incr . vs. cent Gene name Event I D Mea n P value % incr . vs. cent LYM84 13403 .3 G 0.006 5.30E- 03 87.8 LYM84 13403 .3 N 0.08 2.00E- 06 70.6 LYM84 13401 .2 G 0.007 5.52E- 03 130. 9 LYM84 13403 .2 N 0.073 2.00E- 06 55.9 LYM1 11603 .2 G 0.004 9.31E- 03 42.3 LYM136 13423 .1 N 0.085 3.00E- 06 81.3 LYM84 13403 .2 G 0.005 1.53E- 02 58.5 LYM1 11602 .6 N 0.07 1.40E- 05 49.8 LYM1 11602 .6 G 0.005 2.06E- 02 50.4 LYM136 13421 .6 N 0.075 2.50E- 05 60.5 LYM136 13423 .1 G 0.007 3.33E- 02 123. 6 LYM84 13403 .1 N 0.07 7.20E- 05 50.5 LYM136 13421 .5 G 0.005 5.81E- 02 72.4 LYM136 13421 .5 N 0.074 1.10E-04 57.9 CONTR OL _ G 0.003 _ 0 LYM1 11603 .2 N 0.071 1.87E- 04 51.2 LYM1 11601 .1 H 0.103 1.93E- 04 78.3 LYM1 11604 .4 N 0.058 2.56E- 02 23.7 LYM84 13403 .3 H 0.11 1.55E- 03 91.3 LYM1 11602 .1 N 0.056 7.26E- 02 19.1 LYM84 13403 .2 H 0.113 1.81E- 03 95.7 CONTR OL _ N 0.047 _ 0 LYM136 13423 .2 H 0.13 4.05E- 03 126. 1 LYM136 13421 .8 I 1.163 9.90E- 05 51.6 LYM1 11603 .2 H 0.093 4.55E- 03 60.9 LYM136 13423 .1 I 1.209 8.12E- 04 57.6 LYM84 13404 .4 H 0.13 6.79E- 03 126. 1 LYM1 11603 .2 I 0.993 1.65E- 03 29.4 LYM1 11602 .6 H 0.103 7.66E- 03 78.3 LYM84 13404 .4 I 1.095 2.56E- 03 42.7 LYM136 13423 .1 H 0.148 9.13E- 03 156. 5 LYM84 13403 .2 I 1.009 3.97E- 03 31.5 LYM136 13421 .8 H 0.128 1.35E- 02 121. 7 LYM84 13403 .1 I 0.997 4.57E- 03 30 LYM84 13401 .2 H 0.133 1.58E- 02 130. 4 LYM136 13423 .2 I 1.104 4.86E- 03 43.9 LYM136 13421 .5 H 0.105 2.31E- 02 82.6 LYM84 13403 .3 I 1.035 8.51E- 03 34.9 LYM136 13421 .6 H 0.11 2.99E- 02 91.3 LYM84 13401 .2 I 1.049 2.01E- 02 36.8 LYM84 13403 .1 H 0.095 9.17E- 02 65.2 LYM136 13421 .6 I 0.996 2.96E- 02 29.8 CONTR OL _ H 0.058 _ 0 LYM1 11601 .1 I 0.899 6.99E- 02 17.1 LYM136 13421 .8 M 0.805 0.00E+ 00 84 LYM1 11604 .4 I 0.884 9.29E- 02 15.3 LYM84 13403 .2 M 0.683 0.00E+ 00 56 CONTR OL _ I 0.767 _ 0 LYM1 11602 .6 M 0.713 1.50E- 04 62.9 LYM1 11603 .2 J 8.538 1.59E- 03 30 LYM84 13404 M 0.893 6.76E- 104 LYM84 13403 J 8.743 1.76E- 33.1 2016213786 11 Aug 2016 424 Gene name Event I D Mea n P value % incr . vs. cont Gene name Event I D Mea n P value % incr . vs. cont A 04 .1 02 LYM1 11601 .1 M 0.84 7.01E- 04 92 LYM136 13421 .8 J 10.11 5 2.04E- 02 54 LYM136 13423 .2 M 0.835 7.48E- 04 90.9 LYM84 13403 .2 J 8.468 3.82E- 02 28.9 LYM84 13403 .1 M 0.675 1.60E- 03 54.3 LYM84 13404 .4 J 9.658 5.32E- 02 47 LYM84 13403 .3 M 0.79 2.37E- 03 80.6 LYM1 11604 .4 J 7.745 5.47E- 02 17.9 LYM84 13401 .2 M 0.86 2.92E- 03 96.6 LYM136 13423 .1 J 10.39 8 6.40E- 02 58.3 LYM136 13423 .1 M 0.84 4.59E- 03 92 LYM1 11601 .1 J 7.858 6.86E- 02 19.6 LYM1 11603 .2 M 0.693 8.94E- 03 58.3 CONTR OL — J 6.568 — 0 LYM136 13421 .6 M 0.738 9.38E- 03 68.6 LYM136 13421 .8 L 7.173 1.89E- 03 21.6 LYM1 11604 .4 M 0.54 1.15E- 02 23.4 LYM84 13404 .4 L 7.105 3.22E- 03 20.4 LYM136 13421 .5 M 0.685 1.62E- 02 56.6 LYM84 13403 .1 L 6.823 8.12E- 03 15.7 LYM1 11602 .1 M 0.538 5.30E- 02 22.9 LYM1 11603 .2 L 6.868 9.56E- 03 16.4 CONTR OL _ M 0.438 _ 0 LYM1 11601 .1 L 6.538 2.95E- 02 10.8 LYM136 13423 .2 L 6.88 3.42E- 02 16.6 LYM84 13403 .2 L 6.445 7.62E- 02 9.3 CONTR OL — L 5.899 — 0 Table 38. Results of the tissue culture T2 experiments. Provided are the measured values of each tested parameter [parameters (ID.) G-L according to the parameters described in Table 37 above] in plants expressing the indicated polynucleotides. “Ev” = event; “P” = P-value; “Mean ” = the average of measured parameter across events. % incr. vs. cont. = percentage of increase versus control (as compared to control). 5

These results demonstrate that the polynucleotides of the invention are capable of improving yield and additional valuable important agricultural traits such as increase 10 of biomass, abiotic stress tolerance, nitrogen use efficiency, yield, vigor, fiber yield and/or quality. Thus, transformed plants showing improved fresh and dry weight demonstrate the gene capacity to improve biomass a key trait of crops for forage and plant productivity; transformed plants showing improvement of seed yield demonstrate the genes capacity to improve plant productivity; transformed plants showing 2016213786 11 Aug 2016 425 improvement of plot coverage and rosette diameter demonstrate the genes capacity to improve plant drought resistance as they reduce the loss of soil water by simple evaporation and reduce the competition with weeds; hence reduce the need to use herbicides to control weeds. Transformed plants showing improvement of relative growth rate of various organs (leaf and 5 root) demonstrate the gene capacity to promote plant growth and hence shortening the needed growth period and/or alternatively improving the utilization of available nutrients and water leading to increase of land productivity; Transformed plants showing improvement of organ number as demonstrated by the leaf number parameter exhibit a potential to improve biomass yield important for forage crops and improve the plant productivity; Transformed plants 10 showing increased root length and coverage demonstrate the gene capacity to improve drought resistance and better utilization of fertilizers as the roots can reach larger soil volume; Transformed plants showing improvement of leaf petiole relative area and leaf blade area demonstrate the genes capacity to cope with limited light intensities results from increasing the plant population densities and hence improve land productivity. L5

Although the invention has been described in conjunction with specific embodiments thereof, it is evident that many alternatives, modifications and variations will be apparent to those skilled in the art. Accordingly, it is intended to embrace all such alternatives, modifications and variations that fall within the spirit and broad scope of the appended claims. ’0 All publications, patents and patent applications mentioned in this specification are herein incorporated in their entirety by reference into the specification, to the same extent as if each individual publication, patent or patent application was specifically and individually indicated to be incorporated herein by reference. In addition, citation or identification of any reference in this application shall not be construed as an admission that such reference is 25 available as prior art to the present invention. To the extent that section headings are used, they should not be construed as necessarily limiting.

Any reference to publications cited in this specification is not an admission that the disclosures constitute common general knowledge in Australia. 426 2016213786 11 Aug 2016

Other embodiments of the invention as described herein are defined in the following paragraphs: 1. A method of increasing yield, biomass, growth rate, vigor, oil content, fiber yield, fiber quality, abiotic stress tolerance, and/or nitrogen use efficiency of a plant, comprising expressing within the plant an exogenous polynucleotide comprising a nucleic acid sequence at least 80 % identical to SEQ ID NO: 3487, 1-239, 467-1973, 3481-3486, 3488-3674, 3738 or 3739, thereby increasing the yield, biomass, growth rate, vigor, oil content, fiber yield, fiber quality, abiotic stress tolerance, and/or nitrogen use efficiency of the plant. 2. A method of increasing yield, biomass, growth rate, vigor, oil content, fiber yield, fiber quality, abiotic stress tolerance, and/or nitrogen use efficiency of a plant, comprising expressing within the plant an exogenous polynucleotide comprising the nucleic acid sequence selected from the group consisting of SEQ ID NOs: 3487, 1-239, 467-1973, 3481-3486, 3488-3674, and 3738-3739, thereby increasing the yield, biomass, growth rate, vigor, oil content, fiber yield, fiber quality, abiotic stress tolerance, and/or nitrogen use efficiency of the plant. 3. A method of increasing yield, biomass, growth rate, vigor, oil content, fiber yield, fiber quality, abiotic stress tolerance, and/or nitrogen use efficiency of a plant, comprising expressing within the plant an exogenous polynucleotide comprising a nucleic acid sequence encoding a polypeptide at least 80 % identical to SEQ ID NO: 246, 240-245, 247-465, 1974-3480, 3675-3736 or 3737, thereby increasing the yield, biomass, growth rate, vigor, oil content, fiber yield, fiber quality, abiotic stress tolerance, and/or nitrogen use efficiency of the plant. 4. A method of increasing yield, biomass, growth rate, vigor, oil content, fiber yield, fiber quality, abiotic stress tolerance, and/or nitrogen use efficiency of a plant, comprising expressing within the plant an exogenous polynucleotide comprising a nucleic acid sequence encoding a polypeptide selected from the group consisting of SEQ ID NOs: 246, 240-245, 247-465, 1974-3480, and 3675-3737, thereby increasing the yield, biomass, growth rate, vigor, oil content, fiber yield, fiber quality, abiotic stress tolerance, and/or nitrogen use efficiency of the plant. 5. An isolated polynucleotide comprising a nucleic acid sequence at least 80 % identical to SEQ ID NO: 3487, 1-239, 467-1973, 3481-3486, 3488-3674, 3738 or 3739, wherein said nucleic acid sequence is capable of increasing yield, biomass, growth rate, vigor, oil content, fiber yield, fiber quality, abiotic stress tolerance, and/or nitrogen use efficiency of a plant. 6. An isolated polynucleotide comprising the nucleic acid sequence selected from the group consisting of SEQ ID NOs: 3487, 1-239, 467-1973, 3481-3486, 3488-3674, and 3738-3739. 7. An isolated polynucleotide comprising a nucleic acid sequence encoding a polypeptide 427 2016213786 11 Aug 2016 which comprises an amino acid sequence at least 80 % homologous to the amino acid sequence set forth in SEQ ID NO: 246, 240-245, 247-465, 1974-3480, 3675-3736 or 3737, wherein said nucleic acid sequence is capable of increasing yield, biomass, growth rate, vigor, oil content, fiber yield, fiber quality, abiotic stress tolerance, and/or nitrogen use efficiency of a plant. 8. An isolated polynucleotide comprising a nucleic acid sequence encoding a polypeptide which comprises the amino acid sequence selected from the group consisting of SEQ ID NOs: 246, 240-245, 247-465, 1974-3480, and 3675-3737. 9. A nucleic acid construct comprising the isolated polynucleotide of paragraph 5, 6, 7 or 8, and a promoter for directing transcription of said nucleic acid sequence in a host cell. 10. An isolated polypeptide comprising an amino acid sequence at least 80 % homologous to SEQ ID NO: 246, 240-245, 247-465, 1974-3480, 3675-3736 or 3737, wherein said amino acid sequence is capable of increasing yield, biomass, growth rate, vigor, oil content, fiber yield, fiber quality, abiotic stress tolerance, and/or nitrogen use efficiency of a plant. 11. An isolated polypeptide comprising the amino acid sequence selected from the group consisting of SEQ ID NOs: 246, 240-245, 247-465, 1974-3480, and 3675-3737. 12. A plant cell exogenously expressing the polynucleotide of paragraph 5, 6, 7 or 8 or the nucleic acid construct of paragraph 9. 13. A plant cell exogenously expressing the polypeptide of paragraph 10 or 11. 14. The method of paragraph 1 or 3, the isolated polynucleotide of paragraph 5 or 7, the nucleic acid construct of paragraph 9, or the plant cell of paragraph 12, wherein said nucleic acid sequence is as set forth in SEQ ID NO: 3487, 1-239, 467-1973, 3481-3486, 3488-3674, 3738 or 3739. 15. The method of paragraph 1, 2, 3 or 4, the isolated polynucleotide of paragraph 5, 6, 7 or 8, the nucleic acid construct of paragraph 9, or the plant cell of paragraph 12, wherein said polynucleotide consists of the nucleic acid sequence selected from the group consisting of SEQ ID NOs: 3487, 1-239, 467-1973, 3481-3486, 3488-3674, and 3738-3739. 16. The method of paragraph 1, 2, 3 or 4, the isolated polynucleotide of paragraph 5, 6, 7 or 8, the nucleic acid construct of paragraph 9, or the plant cell of paragraph 12, wherein said nucleic acid sequence encodes an amino acid sequence at least 80 % homologous to SEQ ID NO: 246, 240-245, 247-465, 1974-3480, 3675-3736 or 3737. 17. The method of paragraph 1, 2, 3 or 4 or the isolated polynucleotide of paragraph 5, 6, 7 or 8, the nucleic acid construct of paragraph 9, or the plant cell of paragraph 12, wherein said nucleic acid sequence encodes the amino acid sequence selected from the group consisting of SEQ ID NOs: 246, 240-245, 247-465, 1974-3480, and 3675-3737. 2016213786 11 Aug 2016 428 18. The plant cell of paragraph 12 or 13, wherein said plant cell forms a part of a plant. 19. The method of paragraph 1, 2, 3 or 4, the isolated polynucleotide of paragraph 5 or 7, or the nucleic acid construct of paragraph 9, the isolated polypeptide of paragraph 10, the plant cell of paragraph 12 or 13, wherein the abiotic stress is selected from the group consisting of salinity, drought, water deprivation, low temperature, high temperature, heavy metal toxicity, anaerobiosis, nutrient deficiency, nutrient excess, atmospheric pollution and UV irradiation. 20. The method of paragraph 1, 2, 3 or 4, further comprising growing the plant under the abiotic stress. 21. The method of paragraph 1, 2, 3 or 4, further comprising growing the plant under nitrogen-limiting conditions.

Still further embodiments are within the scope of the following claims.

Claims

1. A method of increasing yield,, biomass, growth rate, abiotic stress tolerance, and/or nitrogen use efficiency of a plant, comprising over-expressing within the plant a polypeptide comprising an amino acid sequence at least 80% identical to SEQ ID NO: 322, thereby increasing the yield, biomass, growth rate, abiotic stress tolerance, and/or nitrogen use efficiency of the plant.

2. A method of producing a crop comprising growing a crop plant over-expressing a polypeptide comprising an amino acid sequence at least 80% homologous to the amino acid sequence set forth in SEQ ID NO: 322, wherein the crop plant is derived from plants which over-express said polypeptide as compared to a wild type plant of the same species which is grown under the same growth conditions, and which have been selected for increased yield, increased biomass, increased growth rate, increased abiotic stress tolerance, and/or increased nitrogen use efficiency as compared to said wi ld type plant of the same species which is grown under the same growth conditions, and the crop plant having the increased yield, increased biomass, increased growth rate, increased abiotic stress tolerance, and/or increased nitrogen use efficiency, thereby producing the crop.

3. A nucleic acid construct comprising an isolated polynucleotide comprising a nucleic add sequence encoding a polypeptide which comprises an amino acid sequence at least 90% homologous to the amino acid sequence set forth in SEQ ID NO: 322, and a heterologous promoter operably linked to said Isolated polynucleotide, wherein said nucleic acid sequence is capable of increasing yield, biomass, growth rate, abiotic stress tolerance, and/or nitrogen use efficiency of a plant.

4. A nucleic acid construct comprising an isolated polynucleotide comprising a nucleic acid sequence at least 85% identical to SEQ ID NO: 3563 or 85, and a heterologous promoter operably linked to said isolated polynucleotide, wherein said nucleic acid sequence is capable of increasing yield, biomass, growth rate, abiotic stress tolerance, and/or nitrogen use efficiency of a. plant.

5. An isolated polypeptide comprising an amino acid sequence at least 90% homologous to SEQ ID NO: 322, wherein said amino acid sequence is capable of increasing yield, biomass, growth rate, abiotic stress tolerance, and/or nitrogen use efficiency of a plant.

6. A transgenic plant cell comprising the nucleic acid construct of claim 3 or claim 4.

7. A transgenic plant cell exogenously expressing the isolated polypeptide of claim 5.

8. A transgenic plant comprising the cell of claim 6 or claim 7, or the nucleic acid construct of claim 3 or claim 4.

9. A method of selecting plants having increased yield, biomass, growth rate, abiotic stress tolerance, and/or nitrogen use efficiency, the method comprising selecting plants transformed with the nucleic acid construct of claim 3 or claim 4 for an increased trait as compared to a native plant of the same species which is grown under the same growth conditions, wherein said trait is selected from the group consisting of: yield, biomass, growth rate, abiotic stress tolerance, and nitrogen use efficiency.

10. The method of claim 1 or claim 2, wherein said polypeptide is expressed from a polynucleotide comprising a nucleic acid sequence which exhibits at least 80% sequence identity to SEQ ID NO: 3563 or 85.

11. The method of claim 1 or claim 2, the nucleic acid construct of claim 3, the isolated polypeptide of claim 5, the plant cell of claim 6 or claim 7, or the transgenic plant of claim 8 or claim 9, wherein said polypeptide is at least 90% identical to SEQ ID NO: 322.

12. The method of claim 1 or claim 2, the nucleic acid construct of claim 3, the isolated polypeptide of claim 5, the plant cell of claim 6 or claim 7, or the transgenic plant of claim 8 or claim 9, wherein said polypeptide is at least 95% identical to SEQ ID NO: 322.

13. The method of claim 1 or claim 2, the nucleic acid construct of claim 3, the isolate polypeptide of claim 5, the plant cell of claim 6 or claim 7, or the transgenic plant of claim 8 or claim 9, wherein said polypeptide is set forth in SEQ ID NO: 322, 2821, 2822, 2823, 2824, 2825, 2826, 2827, 2828, 2829, 2830, 2831, 2832, 2833, 2834, 2835, 2836, 2837, 2838, 2839, 2840, 2841, 2842, 2843, or 2844.

14. The method of claim 10, the nucleic acid construct of claim 3 or claim 4, the plant cell of claim 6, or the transgenic plant of claim 8, wherein said nucleic acid sequence is at least 90% identical to the polynucleotide set forth in SEQ ID NO: 3563 or 85.

15. The method of claim 10, the nucleic acid construct of claim 3 or claim 4, the plant cell of claim 6, or the transgenic plant of claim 8, wherein said nucleic acid sequence is as set forth in SEQ ID NO: 3563, 85, 1314, 1315, 1316, 1317, 1318, 1319, 1320, 1321, 1322, 1323, 1324, 1325, 1327, 1328, 1329, 1330, 1331, 1332, 1333, 1334, 1335, 1336, or 1337.

16. The method of any one of claims 1, 2 and 9-15, the nucleic acid construct of any one of claims 3, 4 and 11-15, the isolated polypeptide of any one of claims 5 and 11-15, the plant cell of any one of claims 6, 9 and 11-15, or the transgenic plant of any one of claims 8 and 11-15, wherein the abiotic stress is selected from the group consisting of salinity, drought, water deprivation, low temperature, high temperature, heavy metal toxicity, anaerobiosis, nutrient deficiency, nutrient excess, atmospheric pollution and UV irradiation.

17. The method of any one of claims 1, 2 and 9-15, the nucleic acid construct of any one of claims 3, 4 and 11-15, the isolated polypeptide of any one of claims 5 and 11-15, the plant cell of any one of claims 6, 7 and 11-15, or the transgenic plant of any one of claims 8 and 11-15, wherein the abiotic stress is salinity stress.

18. The method of any one of claims 1, 2 and 9-17, further comprising growing the plant under the abiotic stress.

19. The method of any one of claims 1, 2 and 9-17, further comprising growing the plant under nitrogen-limiting conditions.

20. The method of any one of claims 1, 2 and 10-19, further comprising selecting said plant for an increased trait as compared to a native plant of the same species which is grown under the same growth conditions, wherein said trait is selected from the group consisting of: yield, biomass, growth rate, abiotic stress tolerance, and nitrogen use efficiency.