AU2016301189B2 - Methods of identifying male fertility status and embryo quality - Google Patents

Abstract

Methods are provided of identifying a male fertility condition in a subject. Methods of performing a fertility treatment and an in vitro fertilization procedure are also provided. The methods may comprise determining the DNA methylation pattern of DNA extracted from a semen sample of a subject.

Description

METHODS OF IDENTIFYING MALE FERTILITY STATUS AND EMBRYO QUALITY CROSS-REFERENCE TO RELATED APPLICATION

[0001] This application claims the benefit of United States Provisional Application No. 62/201,907, filed August 6, 2015, which is hereby incorporated by reference in its entirety. TECHNICAL FIELD

[0002] The present disclosure relates to methods of identifying a male fertility condition in a subject. The disclosure also relates to methods of identifying embryo quality. More particularly, the disclosure relates to methods of performing a fertility treatment. BACKGROUND

[0003] Male infertility diagnosis can be determined by the standard semen analysis. With the exception of modifications to criteria for morphological grading, the semen analysis has generally changed little over the past several decades. Studies have evaluated the prognostic value of the various semen parameters evaluated by the standard semen analysis (see Esteves SC et al. Urology. 2012;79(1):16-22; Barratt CL et al. Asian Journal of Andrology. 2011;13(1):53-8; and Bonde JP et al. Lancet. 1998;352(9135):1172-7, each of which is incorporated by reference herein in its entirety). While the parameters assessed may be a benchmark in evaluating a man's fertility potential, with the exception of severely diminished sperm count or motility, however, the predictive value of the semen analysis for fertility is generally modest. A study of the predictive value of the semen analysis indicated that while the semen analysis can be useful for classifying men as sub-fertile, of indeterminate fertility, or fertile, it is generally ineffective for diagnosing infertility because many infertile men display semen parameters that fall within normal ranges (see Guzick DS et al. The New England Journal of Medicine. 2001;345(19):1388-93, which is incorporated by reference herein in its entirety).

[0004] The main parameters evaluated in the semen analysis, namely sperm count, motility, viability, and morphology, can be somewhat subjective, and consequently they can be subject to technical error. While continual training and assessment, quality control measures, and proficiency testing may all serve to minimize technical error, studies have demonstrated that coefficients of variation (CVs) between labs and technicians can fall in the 20-30% range, with higher CVs reported in some studies (see Gandini L et al. International Journal of Andrology. 2000;23(1):1-3; Neuwinger J et al. Fertility and Sterility. 1990;54(2):308-14; and Brazil C et al. Journal of Andrology. 2004;25(4):645-56, each of which is incorporated by reference herein in its entirety).

[0005] In addition to technical variability, semen parameters within the same individual can vary between collections, with CVs of around 30% between two collections from the same man, based on a recent study that evaluated more than 5,000 men (see Leushuis E et al. Fertility and Sterility. 2010;94(7):2631-5, which is incorporated by reference herein in its entirety). Given this variability, the World Health Organization (WHO) recommends that at least two semen analyses be performed prior to clinical decision-making (see World Health Organization. WHO laboratory manual for the examination and processing of human semen. 5th ed. Geneva: World Health Organization; 2010, which is incorporated by reference herein in its entirety).

[0006] Lastly, the predictive value of the various semen parameters can be limited. Studies have been performed to characterize semen parameters in healthy, fertile men, and fertile and sub-fertile ranges have been defined for each of the parameters assessed (see Cooper TG et al. Human Reproduction Update. 2010;16(3):231-45 and Guzick DS et al. The New England Journal of Medicine. 2001;345(19):1388-93, each of which is incorporated by reference herein in its entirety). Nevertheless, the parameters assessed by the standard semen analysis can fall short of predicting fertility potential.

[0007] Adjunct tests have been developed, such as sperm DNA damage assessment, capacitation and acrosome reaction tests, egg and zona penetration assays, anti-sperm antibody testing, and aneuploidy screening (see Zini A et al. Human Reproduction. 2008;23(12):2663-8; Sanchez R et al. Andrologia. 1991;23(3):197-203; Lee MA et al. Fertility and Sterility. 1987;48(4):649-58; Haas GG, Jr. et al. The New England Journal of Medicine. 1980;303(13):722-7; Burkman LJ et al. Fertility and Sterility. 1988;49(4):688-97; and Yanagimachi R et al. Biology of Reproduction.

1976;15(4):471-6, each of which is incorporated by reference herein in its entirety), and while these tests can be helpful in characterizing fertility potential in select patients, the predictive values of the assays can be suboptimal (see Yanagimachi R et al. Biology of Reproduction. 1976;15(4):471-6, which is incorporated by reference herein in its entirety).

[0008] A few genetic markers for male infertility have been identified, such as Y chromosome microdeletions (see Tiepolo L et al. Human Genetics. 1976;34(2):119-24, which is incorporated by reference herein in its entirety), Klinefelter syndrome (see Lanfranco F et al. Lancet. 2004;364(9430):273-83, which is incorporated by reference herein in its entirety), and DPY19L and SPATA16 mutations (see Dam AH et al. American Journal of Human Genetics. 2007;81(4):813-20; Elinati E et al. Human Molecular Genetics. 2012;21(16):3695-702; Harbuz R et al. American Journal of Human Genetics. 2011;88(3):351-61; and Koscinski I et al. American Journal of Human Genetics. 2011;88(3):344-50, each of which is incorporated by reference herein in its entirety), among others. These genetic features, however, are generally associated with extreme male infertility phenotypes including severe oligozoospermia, nonobstructive azoospermia, and complete globozoospermia, thus accounting for a small percentage of infertile men.

[0009] Epigenetics can refer to modifiable but generally stable, heritable modifications to the DNA or chromatin packaging. Direct DNA modifications can consist of methylation alteration to the 5-carbon position of cytosine bases, generally in the context of cytosine-guanine dinucleotides (CpGs). BRIEF DESCRIPTION OF THE DRAWINGS

[0010] The embodiments disclosed herein will become more fully apparent from the following description and appended claims, taken in conjunction with the accompanying drawings.

[0011] FIG. 1A depicts hierarchical clustering of 163 neat samples based on global methylation profile. An out-group of exclusively patient samples with a sub-group strongly enriched for poor embryo samples is apparent.

[0012] FIG. 1B depicts the ROC curve for prediction of patient status (in vitro fertilization (IVF) patient or fertile donor, left panel). Classification was performed by building a one-level decision tree based on Euclidean distance between samples. Training and testing were performed using ten-fold cross-validation. The right panel depicts the ROC curve for prediction of embryo quality. In both cases, high confidence predictions (bottom right of plots) can have a high probability of being correct.

[0013] FIG. 1C depicts classification statistics for the ROC curves of FIG. 1B. Samples were predicted as positive (i.e., a patient sample or a poor embryo-quality sample) when the probability exceeded 50%. In both cases, high specificity and positive predictive value can be achieved.

[0014] FIG. 2A depicts hierarchical clustering of 62 gradient-purified sperm samples based on global methylation profile. Two clear clusters are apparent, one of which contains almost exclusively poor embryo-quality samples.

[0015] FIG. 2B depicts the ROC curve for prediction of patient status (IVF patient or fertile donor) from the 62 gradient purified samples (left panel). Classification was performed by building a one-level decision tree based on Euclidean distance between samples. Training and testing were performed using ten-fold cross-validation. The right panel depicts the ROC curve for prediction of embryo quality from the subset of 45 samples for which this information is known. Although classification of patient status is degraded from that with unpurified samples, the ability to predict poor embryo-quality is markedly improved.

[0016] FIG. 2C depicts classification statistics for the ROC curves of FIG. 2B. Samples were predicted as positive (i.e., a patient sample or a poor embryo-quality sample) when the probability exceeded 50%. In the case of predicting poor embryo quality, very high specificity and positive predictive value can be achieved.

[0017] FIG. 3A depicts the number of differentially methylated CpGs between unpurified donor and IVF patient samples before and after correction for multiple hypothesis testing using both the actual donor/patient labels and randomly shuffled donor/patient labels as a control.

[0018] FIG. 3B depicts the distribution of p-values for all profiled CpGs from tests of differential methylation between donor and IVF-patient samples using both actual labels and randomly shuffled donor/patient labels as a control.

[0019] FIG. 3C depicts the proportion of differentially methylated CpGs (before correction for multiple hypothesis testing) that fall within regions annotated as shown, for both actual donor/IVF-patient labels and randomly permuted labels.

[0020] FIG. 3D depicts a histogram showing the number of CpGs that were contained in the top 100 most differentially methylated CpGs identified in only 1 fold, exactly 2 folds, exactly 3 folds, and so on. The inset depicts the number of CpGs contained in all 10 folds for both real labels and permuted labels in higher detail. Samples are split into 10 stratified equally-sized groups. A fold is formed by taking 9 of these groups and leaving one group out (allowing 10 separate analyses). For each fold, the samples in the 9 retained groups are used to identify differentially methylated CpGs using both real donor/IVF-patient labels and randomly permuted labels as a control.

[0021] FIG. 3E depicts ROC curves for classifiers, analogous to those of FIGS. 2A 2C, that were trained using a subset of the top 50, 1,000, 50,000, and 400,000 most significantly differentially-methylated CpGs.

[0022] FIG. 3F depicts ROC curves for classifiers from a range of classifiers that were trained on the top 500 most differentially methylated CpGs.

[0023] FIG. 4A depicts gene ontology (GO) analysis of the top 1,000 genes after sorting genes by number of differentially methylated CpGs. All terms that were significant (correct p-value < 0.05) when either comparing IVF patient samples to fertile donors, or when comparing good- and poor-embryogenesis IVF patient samples are included, with the exception of 24 terms associated with gene expression and cellular metabolism, which are omitted for clarity of visualization.

[0024] FIG. 4B depicts the absolute number and proportion of genes with differentially methylated promoter regions (p < 0.01, Wilcoxon sign-rank test, purified samples) that are known to be imprinted.

[0025] FIG. 5A depicts hierarchical clustering of global methylation profiles for 181 samples with duplicates omitted (i.e., where both purified and non-purified samples were processed from the same patient/donor, which accounts for 44 out of 225 samples, only the purified sample is included in this plot). The dendrogram is annotated with the purification method used for each sample.

[0026] FIG. 5B depicts hierarchical clustering of methylation profiles for the 44 IVF patients for which both purified and non-purified samples were processed (i.e., 88 samples in total are plotted here). Note that for each unpurified sample, its nearest neighbor is the purified sample from the same patient.

[0027] FIG. 6A depicts the number of differentially methylated CpGs between purified good and poor embryogenesis samples before and after correction for multiple hypothesis testing using both the actual good/poor labels and randomly shuffled good/poor labels as a control.

[0028] FIG. 6B depicts the distribution of p-values for all profiled CpGs from a test of differential methylation between good and poor embryogenesis using both actual labels and randomly shuffled good/poor labels as a control.

[0029] FIG. 6C depicts the proportion of differentially methylated CpGs (before correction for multiple hypothesis testing) that fall within regions annotated as shown, for both actual good/poor embryo quality labels and randomly permuted labels.

[0030] FIG. 6D depicts a histogram showing the number of CpGs that were contained in the top 100 most differentially methylated CpGs identified in only 1 fold, exactly 2 folds, exactly 3 folds, and so on. Samples are split into 10 stratified equally sized groups. A fold is formed by taking 9 of these groups and leaving one group out (allowing 10 ways of doing this). For each fold, the samples in the 9 retained groups are used to identify differentially methylated CpGs using both real good/poor embryogenesis labels and randomly permuted labels as a control.

[0031] FIG. 6E depicts the evaluation of classifiers, analogous to those of FIGS. 2A 2C, that were trained using a subset of the top x most differentially-methylated CpGs (where x is varied along the x-axis of the plots). The sensitivity, specificity, positive predictive value, and negative predictive value of each were evaluated as a function of how many CpGs were selected.

[0032] FIG. 7 depicts an exemplary ROC curve that can be plotted when using a fertile reference methylome to identify infertile samples.

DETAILED DESCRIPTION

[0033] The present disclosure provides methods of identifying a male fertility condition in a subject and/or predicting a level of male fertility in a subject. This disclosure also provides methods of identifying and/or predicting embryo quality. Furthermore, the disclosure provides methods of performing fertility treatments.

[0033a] In a first aspect, the present invention provides a method of identifying a male fertility condition in a subject, comprising:

extracting DNA from a semen sample from the subject;

identifying a methylation pattern of the extracted DNA;

comparing the methylation pattern of the extracted DNA to a control pattern of DNA methylation; and

determining if the methylation pattern of the extracted DNA is different from the control pattern of DNA methylation, wherein the difference comprises aberrant methylation associated with the following genes: AHDC1, ALOX5AP, BTBD17, CXXC11, EEF1A2, FBLN2, FGF18, GRM6, HIST1H4J, HIST1H4K, INPP5A, JAG2, KCNQ1, KIAA0319L, LRRC45, MIR4734, MLLT6, MTMR6, MXRA7, NCDN, NDUFS6, NDUFS8, OGFOD2, PSTPIP1, RAP1GAP2, SERPINF2, STRA13, SYT8, TCIRG1, USP24, and TNN12, and wherein a different methylation pattern of the extracted DNA indicates that the subject has a male fertility condition.

[0033b] Ina second aspect, the present invention provides a method of predicting in vitro fertilization (IVF) embryo quality, comprising:

collecting a semen sample from a subject;

extracting DNA from a portion of the semen sample;

identifying a methylation pattern of the extracted DNA;

comparing the methylation pattern of the extracted DNA to a control pattern of DNA methylation; and determining if the methylation pattern of the extracted DNA is different from the control pattern of DNA methylation, wherein the difference comprises aberrant methylation associated with the following genes: AHDC1, ALOX5AP, BTBD17, CXXC11, EEF1A2, FBLN2, FGF18, GRM6, HIST1H4J, HIST1H4K, INPP5A, JAG2, KCNQ1, KIAA0319L, LRRC45, MIR4734, MLLT6, MTMR6, MXRA7, NCDN, NDUFS6, NDUFS8, OGFOD2, PSTPIP1, RAP1GAP2, SERPINF2, STRA13, SYT8, TCIRG1, USP24, and TNN12, and wherein a different methylation pattern of the extracted DNA indicates that an embryo generated via fertilization with the semen sample is at risk of being a poor quality IVF embryo.

[0033c] In a third aspect, the present invention provides a method of making a fertile reference methylome, the method comprising:

obtaining a plurality of sperm cell samples from fertile sperm donors;

determining a fraction of sperm cells in each of the plurality of sperm cell samples that are methylated at the following genes: AHDC1, ALOX5AP, BTBD17, CXXC11, EEF1A2, FBLN2, FGF18, GRM6, HIST1H4J, HIST1H4K, INPP5A, JAG2, KCNQ1, KIAA0319L, LRRC45, MIR4734, MLLT6, MTMR6, MXRA7, NCDN, NDUFS6, NDUFS8, OGFOD2, PSTPIP1, RAP1GAP2, SERPINF2, STRA13, SYT8, TCIRG1, USP24, and TNN12; and

defining an expected range of methylation at following genes: AHDC1, ALOX5AP, BTBD17, CXXC11, EEF1A2, FBLN2, FGF18, GRM6, HIST1H4J, HIST1H4K, INPP5A, JAG2, KCNQ1, KIAA0319L, LRRC45, MIR4734, MLLT6, MTMR6, MXRA7, NCDN, NDUFS6, NDUFS8, OGFOD2, PSTPIP1, RAP1GAP2, SERPINF2, STRA13, SYT8, TCIRG1, USP24, and TNN12 based on the fraction of sperm cells in each of the plurality of sperm cell samples that are methylated at of the following genes: AHDC1, ALOX5AP, BTBD17, CXXC11, EEF1A2, FBLN2, FGF18, GRM6, HIST1H4J, HIST1H4K, INPP5A, JAG2, KCNQ1, KIAA0319L, LRRC45, MIR4734, MLLT6, MTMR6, MXRA7, NCDN, NDUFS6, NDUFS8, OGFOD2, PSTPIP1, RAP1GAP2, SERPINF2, STRA13, SYT8, TCIRG1, USP24, and TNN12.

[0034] It will be readily understood that the embodiments, as generally described herein, are exemplary. The following more detailed description of various embodiments is not intended to limit the scope of the present disclosure, but is merely representative of various embodiments. Moreover, the order of the steps or actions of the methods disclosed herein may be changed by those skilled in the art without departing from the scope of the present disclosure. In other words, unless a specific

7a order of steps or actions is required for proper operation of the embodiment, the order or use of specific steps or actions may be modified.

[0035] A "subject" is defined herein as a mammal that may experience a male fertility condition, a male fertility abnormality, decreased fertility, and/or a level of infertility. Examples of subjects include, but are not limited to, humans, horses, pigs, cattle, dogs, cats, rabbits, and aquatic mammals.

[0036] A "methylation pattern" is defined herein as the methylation of a region of genetic material (e.g., a region of a DNA molecule); methylation of a region may include methylation of a plurality of regions. Such methylation can include the absence and/or presence of methylation in a region, the extent of methylation of a region, and/or the actual methylated sequence of the region.

[0037] A "genome-wide methylation pattern" or a "genome-wide DNA methylation pattern" is defined herein as the methylation of a representative portion, a significant portion, and/or a substantial portion of a genome. For example, a genome-wide methylation pattern may comprise a majority of CpGs from CpG islands, a portion of CpG sites outside of CpG islands, and/or a portion of non-CpG sites in the genome of a subject. In another example, a genome-wide methylation pattern may comprise a

7b pattern of methylation at loci across the genome rather than at specific genes and/or genomic features.

[0038] A "control pattern of methylation" or a "control pattern of DNA methylation" is defined herein as a pattern of methylation from a population of males, or a representative sample thereof, that is indicative of a fertile male. A control pattern of methylation can be generated using techniques known in the art. For example, the control pattern of methylation can be an average pattern of methylation generated from a population of males, or a representative sample thereof, that are determined to be fertile (e.g., normozoospermic males with proven fertility).

[0039] An "aberrant pattern of methylation" or an "aberrant pattern of DNA methylation" is defined herein as a methylation pattern that deviates from a control pattern of methylation to an extent that is indicative of a male fertility condition. For example, an aberrant pattern of methylation may be significantly different from a control pattern of methylation, or aberrant patterns of methylation may be significantly different from control patterns of methylation. In another example, a control pattern of methylation may be significantly different from an aberrant pattern of methylation, or control patterns of methylation may be significantly different from aberrant patterns of methylation. Methylation pattern differences may be observed at a plurality of consistently, or substantially consistently, altered loci, or methylation pattern differences may be manifest as increased variability in subjects having aberrant methylation patterns compared with control methylation patterns.

[0040] In some embodiments, differences between aberrant patterns of methylation and control patterns of methylation may be determined at a single CpG level. For example, one or more CpGs may exhibit statistically significant differences in mean methylation between control groups and aberrant groups. In certain embodiments, differences between aberrant patterns of methylation and control patterns of methylation may be determined at an aggregate region level. For example, one or more CpGs within a given region may exhibit statistically significant differences in mean methylation between control groups and aberrant groups, and/or the region as a whole may exhibit a statistically significant difference in mean methylation level.

[0041] In various embodiments, differences between aberrant patterns of methylation and control patterns of methylation may be determined from genome-wide comparisons. For example, the differences between aberrant patterns of methylation and control patterns of methylation may be determined by simultaneously, or substantially simultaneously, comparing methylation patterns based on all profilable CpGs, substantially all profilable CpGs, or a large subset of CpGs. In certain embodiments, an analysis of the differences between aberrant patterns of methylation and control patterns of methylation may be determined in terms of "distance." For example, each sample may represent a point in n-dimensional space, wherein "n" is the number of profilable or profiled CpGs. In terms of "distance," the "n" dimensions can be reduced to a single dimension, and it can be determined if the "distance" of an aberrant profile from a reference point shows a statistically significant difference from those one or more "distances" observed for control profiles.

[0042] In some embodiments, a maximally discriminative model may be utilized. For example, some machine learning methods may aim to learn the maximally discriminative model, regardless of whether any difference between groups or features reaches statistical significance.

[0043] A "male fertility condition" is defined herein as a condition that renders in a male subject some level of infertility, a fertility abnormality, and/or decreased fertility. Those of ordinary skill in the art are capable of distinguishing various levels of infertility, all of which would be considered to be within the present scope.

[0044] The present disclosure provides devices, methods, and systems for detecting fertility in a subject. In one aspect, for example, a method for identifying an aberrant pattern of methylation associated with a male fertility condition may include assaying a pattern of methylation (e.g., a test pattern of methylation) of a representative portion, a significant portion, and/or a substantial portion of a genome of a subject, and comparing the assayed pattern of methylation from the subject with a control pattern of DNA methylation to identify an aberrant pattern of methylation associated with a male fertility condition.

[0045] In another aspect, a method for identifying a male fertility condition may include assaying the degree of methylation or a methylation pattern of a representative portion, a significant portion, and/or a substantial portion of a genome of sperm from a subject (e.g., test sperm), and comparing the degree of methylation or the methylation pattern of the sperm from the subject with a control degree of methylation or a methylation pattern from control sperm to determine a male fertility condition.

[0046] In one aspect of the present invention, a useful method for assaying DNA methylation can include bisulfite treatment. Treating DNA with a bisulfite such as sodium bisulfite can convert unmethylated cytosines to uracils; methylated cytosines can resist deamination and thus generally remain unchanged. The cytosine to uracil transition following bisulfite treatment can provide a useful assay of the methylation pattern or profile of a region of genetic material. Following such treatment, the genetic material can be sequenced to determine the specific methylation pattern.

[0047] Bisulfite treatment can be utilized in analyzing a few candidate loci, or it can be used to perform a broader genome-wide analysis. If a genome-wide or partially genome-wide analysis is desired, genetic material can be captured on an array of genome loci.

[0048] In addition, methods according to the instant disclosure may be useful in predicting success with various treatments of reproductive disorders such as IVF or other artificial reproductive techniques.

[0049] Another aspect of the disclosure relates to methods of identifying a male infertility condition in a subject. In some embodiments, a male infertility condition may be a condition in a male subject that is associated with some level of infertility, a fertility abnormality, and/or decreased fertility. In certain embodiments, a method of identifying a male infertility condition may comprise extracting genetic material such as DNA from a semen sample from a subject. In some embodiments, the semen sample may be a whole ejaculate sample. In some other embodiments, the semen sample may be purified, for example, by somatic cell lysis. Somatic cell lysis may reduce or eliminate white blood cell contamination in the semen sample. In some other embodiments, the semen sample may be purified by a density gradient purification. In certain embodiments, the semen sample, or the purified semen sample, may be pelleted (i.e., via centrifugation) and/or visually inspected to determine whether substantially all contaminating cells are absent from or have been removed from the semen sample.

[0050] The method may also comprise identifying a methylation pattern of the extracted DNA. In some embodiments, the methylation pattern may be a genome-wide methylation pattern. For example, the methylation pattern may include an assessment of the methylation status of cytosines and/or CpG dinucleotides from positions across the genome. Further, the method may comprise comparing the methylation pattern of the extracted DNA to a control pattern of DNA methylation. In various embodiments, the method may comprise determining if the methylation pattern of the extracted DNA is significantly different from the control pattern of DNA methylation, wherein a significantly different methylation pattern of the extracted DNA may indicate that the subject has a male fertility condition.

[0051] In some embodiments, the methylation pattern may be based on a methylation status of at least 50,000 cytosines from the extracted DNA. For example, the methylation pattern may comprise the methylation status of at least 50,000 cytosines (i.e., whether or not cytosines disposed in at least 50,000 positions in the genome are methylated). In some embodiments, the methylation pattern may be based on a methylation status of at least 100,000 cytosines from the extracted DNA, of at least 200,000 cytosines from the extracted DNA, of at least 300,000 cytosines from the extracted DNA, of at least 485,000 cytosines from the extracted DNA, or of another suitable number of cytosines from the extracted DNA.

[0052] In some other embodiments, the methylation pattern may be based on a methylation status of at least 50,000 CpG dinucleotides from the extracted DNA. For example, the methylation pattern may comprise the methylation status of at least 50,000 CpG dinucleotides (i.e., whether or not cytosines disposed in at least 50,000 CpG dinucleotide positions in the genome are methylated). In some embodiments, the methylation pattern may be based on a methylation status of at least 100,000 CpG dinucleotides from the extracted DNA, of at least 200,000 CpG dinucleotides from the extracted DNA, of at least 300,000 CpG dinucleotides from the extracted DNA, of at least 485,000 CpG dinucleotides from the extracted DNA, or of another suitable number of CpG dinucleotides from the extracted DNA.

[0053] In certain embodiments, the methylation pattern of the extracted DNA may be identified by a method selected from, but not limited to, analyzing the methylation pattern via a DNA methylation array, pyrosequencing, reduced representation bisulfite sequencing, targeted bisulfite sequencing, genome-wide bisulfite sequencing, bisulfite patch PCR, or a combination thereof. In various embodiments, the methylation pattern of the extracted DNA may be identified by a method comprising treating at least a portion of the extracted DNA with bisulfite, amplifying the bisulfite-treated DNA, hybridizing the amplified DNA to a DNA methylation array, and/or processing the hybridized DNA methylation array to determine the methylation pattern of the extracted DNA.

[0054] Another aspect of the disclosure relates to a method of performing a fertility treatment. In some embodiments, the method may comprise identifying a subject with a male fertility condition. In various embodiments, the method may comprise identifying a DNA methylation pattern from a semen sample of the subject. The method may also comprise comparing the identified DNA methylation pattern to a control pattern of DNA methylation. The control pattern of DNA methylation may be a methylation pattern from DNA extracted from semen samples from a control population of fertile males. The method may further comprise classifying whether the identified DNA methylation pattern is significantly different from the control pattern of DNA methylation or whether the identified methylation pattern is not significantly different from the control pattern of DNA methylation. In certain embodiments, if the identified methylation pattern is significantly different from the control pattern of DNA methylation, the method may comprise collecting a sample from the subject for use in an IVF procedure. In various embodiments, if the identified methylation pattern is not significantly different from the control pattern of DNA methylation, the method may comprise collecting a semen sample from the subject for use in an artificial insemination procedure.

[0055] As discussed above, in some embodiments, the methylation pattern may be based on a methylation status of at least 50,000 cytosines from the extracted DNA. For example, the methylation pattern may comprise the methylation status of at least 50,000 cytosines (i.e., whether or not cytosines disposed in at least 50,000 positions in the genome are methylated). In some embodiments, the methylation pattern may be based on a methylation status of at least 100,000 cytosines from the extracted DNA, of at least 200,000 cytosines from the extracted DNA, of at least 300,000 cytosines from the extracted DNA, of at least 485,000 cytosines from the extracted DNA, or of another suitable number of cytosines from the extracted DNA.

[0056] As discussed above, in some other embodiments, the methylation pattern may be based on a methylation status of at least 50,000 CpG dinucleotides from the extracted DNA. For example, the methylation pattern may comprise the methylation status of at least 50,000 CpG dinucleotides (i.e., whether or not cytosines disposed in at least 50,000 CpG dinucleotide positions in the genome are methylated). In some embodiments, the methylation pattern may be based on a methylation status of at least 100,000 CpG dinucleotides from the extracted DNA, of at least 200,000 CpG dinucleotides from the extracted DNA, of at least 300,000 CpG dinucleotides from the extracted DNA, of at least 485,000 CpG dinucleotides from the extracted DNA, or of another suitable number of CpG dinucleotides from the extracted DNA. In certain embodiments, as discussed above, the method of fertility treatment may comprise purifying the semen sample.

[0057] Another aspect of the disclosure relates to a method of performing an IVF procedure. In some embodiments, the method may comprise identifying a subject with a male fertility condition. In various embodiments, the method may comprise identifying a DNA methylation pattern from a semen sample of the subject. The method may also comprise comparing the identified DNA methylation pattern to a control pattern of DNA methylation. The control pattern of DNA methylation may be a methylation pattern from DNA extracted from semen samples from a control population of fertile subjects. The method may further comprise classifying whether the identified DNA methylation pattern is significantly different from the control pattern of DNA methylation or whether the identified methylation pattern is not significantly different from the control pattern of DNA methylation. In certain embodiments, if the identified methylation pattern is significantly different from the control pattern of DNA methylation, the method may comprise collecting a sample from the subject for use in an intra-cytoplasmic sperm injection (ICSI) procedure. In various embodiments, if the identified methylation pattern is not significantly different from the control pattern of DNA methylation, the method may comprise collecting a semen sample from the subject for use in a microdrop IVF procedure.

[0058] Yet another aspect of the disclosure relates to a method of identifying or predicting IVF embryo quality. In certain embodiments, sperm DNA methylation patterns may be a predictor of embryo quality following IVF.

[0059] In various embodiments, a method of predicting embryo quality may comprise collecting a semen sample from a subject, extracting DNA from a portion of the semen sample, identifying a methylation pattern of the extracted DNA, comparing the methylation pattern of the extracted DNA to a control pattern of DNA methylation, and/or determining if the methylation pattern of the extracted DNA is significantly different from the control pattern of DNA methylation, wherein a significantly different methylation pattern of the extracted DNA may indicate that an embryo generated via fertilization with the semen sample is at risk of being a poor-quality IVF embryo.

[0060] In some embodiments, the accuracy, the sensitivity, and/or the positive predictive value of the method for detecting a male infertility condition may be greater than 60%. In some other embodiments, the accuracy, the sensitivity, and/or the positive predictive value of the method for detecting a male infertility condition may be greater than 65%, greater than 70%, greater than 75%, greater than 80%, greater than 85%, greater than 90%, or greater than 99%. In certain embodiments, the accuracy, the sensitivity, and/or the positive predictive value of the method for detecting IVF embryo quality may be greater than 60%. In certain other embodiments, the accuracy, the sensitivity, and/or the positive predictive value of the method for detecting IVF embryo quality may be greater than 65%, greater than 70%, greater than 75%, greater than 80%, greater than 85%, greater than 90%, or greater than 99%.

[0061] The present disclosure additionally provides kits for testing for a male fertility condition in a subject. Such a kit can include a kit housing containing assay components operable to detect a test pattern of methylation of genetic material from a semen sample from the subject, instructions describing how to perform an assay using the assay components, and a control pattern of DNA methylation to compare with the test pattern of methylation or to test for a male fertility condition or embryo quality.

[0062] A variety of kit housings are contemplated, and are sufficient to contain the assay components, the instructions, and the control pattern of DNA methylation. Such a kit can comprise an assembly of the required elements and any helpful instructions to perform such methods and tests, for assaying genome-wide methylation to determine a likelihood of a fertility condition or to determine embryo quality. In some aspects, the kit housing can contain a receptacle for containing and/or transporting sperm.

[0063] Additionally, in some aspects the kit can contain a genome array, PCR materials, or the like. Furthermore, the assay components included in the kit can be used to perform any assay capable of determining methylation patterns of genetic material. Non-limiting examples can include a DNA methylation array assay; capture or PCR reagents for pyrosequencing, reduced representation bisulfite sequencing, targeted bisulfite sequencing, genome-wide bisulfite sequencing, bisulfite patch PCR, or a combination thereof; and tools (e.g., computational tools) for data analysis and/or data interpretation.

[0064] It should be noted that an assay component can be any component or material used to perform an assay. The control pattern of DNA methylation can be provided in a number of formats. For example, the control pattern of DNA methylation can be provided as printed media, electronic media, biological material, and the like. Additionally, the control pattern of DNA methylation can be derived from a variety of regions of genetic material.

[0065] In one aspect, an assay can use a custom-designed DNA methylation array that covers a representative portion, a significant portion, and/or a substantial portion of a genome. Such an assay can specifically use semen samples processed by a density gradient preparation or other sperm preparation techniques used for assisted reproductive technology (ART). The selected sperm population used for testing can be a representative pool of sperm population used for ART (e.g., IVF, ICSI, etc.).

[0066] DNA methylation is the attachment or coupling of a methyl group to DNA at a given locus. The human genome comprises about 27 million loci that can be methylated (i.e., CpG dinucleotides). At each of these loci, in an individual cell, the DNA is either methylated or it is not methylated (i.e., there are only two possible values). As a given sperm sample may contain millions of cells, each having its own copy of the genome, the measurement of DNA methylation in a sperm sample may be the fraction of sperm cells in the sperm sample that have methylation at a given locus. For example, a value of 0 (zero) for a given locus may indicate that all sperm cells in the sperm sample are unmethylated. A value of 1 (one) for a given locus may indicate that all sperm cells in the sperm sample are methylated. A value of 0.5 for a given locus may indicate that half of the sperm cells in the sperm sample are methylated. Accordingly, a full human methylome can be about 27 million numbers, each ranging from 0 to 1.

[0067] To determine if a particular locus is aberrantly methylated, in certain embodiments, an expected range of normal methylation at the particular locus may first be defined. Accordingly, a subsequent methylation level seen outside of the expected range of normal methylation at the particular locus (e.g., either higher than the maximum or lower than the minimum) may then be considered an aberrant or abnormal methylation level.

[0068] An expected range of normal methylation at a particular locus can be determined in multiple ways. In some embodiments, given a set of n methylomes from known-fertile sperm donors, for a given locus there are n numbers ranging from 0 to 1, one for each known-fertile donor. First, the highest a% values and the lowest a% values can be discarded (in various embodiments, a = 2.5%, however, other values are also within the scope of this disclosure). The maximum normal methylation level at this locus can be defined as b higher than the highest remaining value (or 1, whichever is smaller). Similarly, the minimum normal methylation level at this locus can be defined as b lower than the smallest remaining value (or 0, whichever is larger). In some embodiments, b = 0.2, however, other values are also within the scope of this disclosure. The value of 0.2 is specific to Illumina's 450K Human Methylation array (the

"450K HM chip"), and is derived from Bibikova et al. (2011, Genomics. 2011;98:288 295, which is incorporated by reference herein in its entirety) where the claim is made that the 450K HM chips "can detect a delta beta of 0.2 with 99% confidence" ('beta' refers to the chips' estimate of the methylation level at a given locus, 'delta' can be read as 'change in').

[0069] In some other embodiments, given a set of n methylomes from known-fertile sperm donors, the parameters of a beta distribution (a, ) can be estimated from the n methylation levels at a given locus (standard methods can be used to estimate these, e.g., maximum likelihood estimate, method of moments, etc.). Two critical values (x and x') in the distribution can be located such that Pr(X < x a,) < p and Pr(X > x' | a, P) < p, where X is the random variable which the n measures of methylation are assumed to have been sampled from. Any subsequent methylation level at this locus which is less than x or greater than x'can then be considered aberrant. Furthermore, p can be corrected for multiple hypothesis testing using, for example, the Bonferoni method.

[0070] In certain embodiments, an additional constraint can be added where a subsequent methylation measure at a given locus is only considered aberrant if it exceeds the critical values and the absolute value of the difference between the new methylation measure and either the mean of the beta distribution exceeds some threshold (e.g., a value of 0.2 for the 450K HM chip). In some embodiments, a variation on this approach can involve not immediately computing the critical value, but using the beta distribution's cumulative distribution function to compute p-values for all loci, then correcting these for multiple hypothesis testing using, for example, the method of Benjamini and Hochberg (see Benjamini Y and Hochberg Y. Journal of the Royal Statistical Society, Series B. 1995;57(1):289-300, which is incorporated by reference herein in its entirety).

[0071] Loci that exhibit a relationship between aberrant methylation and fertility outcome or embryo quality can be identified. In various embodiments, there can be n samples from known-fertile donors and m samples from infertile men. First, a reference fertile methylome can be determined using one of the methods described above. Then, for each sample (i.e., fertile or infertile) those loci that have methylation levels outside of the normal range can be identified. For each locus, a contingency table can be computed (see Table 1). Table 1: Contingency Table

Fertile Infertile Aberrantly methylated A B Not aberrantly methylated C D

[0072] With reference to Table 1, A is the count of the number of samples from known-fertile donors where aberrant methylation was observed at this locus, B is the count of the number of samples from infertile men where aberrant methylation was observed at this locus, C is the count of samples from known-fertile men where aberrant methylation was not observed at this locus, and D is the count of samples from infertile men where aberrant methylation was not observed at this locus. A standard statistical test called Fisher's exact test can be applied to the contingency table (e.g., Table 1) to determine whether there is a statistically significant association between fertility status and aberrant methylation at this locus.

[0073] In various embodiments, the method or process for determining embryo quality can be similar to the process described above for determining fertility status, but with the labels "Fertile" and "Infertile" in Table 1 replaced with "Good embryo quality" and "Poor embryo quality," respectively.

[0074] In certain embodiments, a subject may be shown a histogram depicting a distribution of the number of differentially methylated loci that are usually detected in fertile donors and infertile patients (or good/poor embryo patients), and where the subject falls on the distribution. Generally, fertile-donors/good-embryo-quality patients may have few aberrations, while infertile patients or poor-embryo-quality patients may have more aberrations.

[0075] Genes exhibiting a relationship between aberrant methylation and fertility outcome and/or embryo quality can be determined. In various embodiments, for every human gene, the number of loci with significant association between aberrant methylation and fertility outcome (or embryo quality) either overlapping the gene body, or 5 kilobases upstream of one of the gene's transcription start sites can be counted (referred to herein as "Method 1"). If the number of loci exceeds a predetermined threshold, for example, 2 loci, then it can be considered that the gene is differentially methylated. This method does not require p-values to be computed for individual loci and can be easily computationally tractable.

[0076] In some embodiments, a sliding window of fixed length can be moved across at least a portion of the whole genome. Determination of aberrant methylation within the window can be conducted as discussed above (referred to herein as "Method 2").

[0077] In certain embodiments, Methods 1 and 2, as described above, can be conducted where p-values are available for individual loci. Stouffer's method or Fisher's method can be used for p-value combination to derive a region-wide p-value. In various embodiments, a hidden Markov model can be trained to segment the genome into regions of aberrant methylation and no aberrant methylation.

[0078] Genes can be ranked by prevalence of aberrant methylation. To determine which genes are likely to be most explanatory for fertility outcome or embryo-quality, genes can be ranked based on the number of infertile (or poor embryo-quality) samples present in a database where aberrant methylation is observed at these genes.

[0079] Two ranked lists of genes have also been compiled. Genes at the top of each list show statistically significant associations between aberrant methylation and infertility (or poor embryo-quality), and are observed aberrantly methylated in the largest number of patients. Table 2 is a ranked list of genes that are aberrantly methylated in infertile patients. The number to the left of the gene name is the number of patients. Table 3 is a ranked list of genes that are aberrantly methylated in poor embryo-quality patients. As in Table 2, the number to the left of the gene name in Table 3 is the number of patients. Only genes which exhibit an association with fertility and/or embryo quality are included in each of the lists.

Table 2: Infertility Genes, Ranked 64 SORCS2 26 ZNF137P 21 B4GALNT2 19ABHD8 19 STON1- 18 MAGEA10 60 STARD13 25 C7orf5O 21 BCYRN1 19ANO1 GTF2A1L MAGEA5 52 STARD13-AS2 25 CSMD1 21 Clorfl86 19 ASTN2 19 TBC1D16 18 MAGEC2 50 PTPRN2 25EDNRB 21 C3orf24 19 ATF6B 19TBCB 18 MDC1 48INPP5A 25 FAM107B 21 CARD14 19 ATRAID 19TMEM88 18 MEG3 46 HLA-DPB2 25 GABARAPL3 21 CEND1 19 C5orf63 19 TRIM39 18 MEST 45 MDGA2 25 GABRA2 21 CSGALNACT1 19 C6orf89 19 TRIM39- 18 MESTIT1 42 CNTNAP5 25 HDAC4 21 DFNA5 19 CALD1 RPP21 18 MIR4456 42 ZBTB46 25 HEATR2 21 EPPIN 19 CNTROB 19 TRIM71 18 MORC1 40 CHST8 25 ITPKB 21 EPPIN-WFDC6 19 COL9A2 19 USP49 18 MTRNR2L8 40TBCD 25 LINC00461 21 FMN2 19 CSAG1 19 VIPR2 18 MTSS1L 38 LINC00535 25 NHSL1 21 GNG12-AS1 19 CSNK1A1P1 19 VWA1 18 MTX2 38 XXYLT1 25 PRKAG2 21 HAS1 19 CTCFL 19 WDR90 18 NEURL1B 35 ABT1 25 PSORS1C1 21 HLA-DPA1 19 CTU1 19 WLS 18 NFYA 35 25TESPA1 21 LAMA2 19CYB5D1 19ZNF843 18 NNAT LOC100507034 25 ZFP57 21 MFF 19 DDAH2 18ACTG1 18 NOSIP 35 PFKP 25 ZNF774 21 PCDHA5 19 DNAH14 18 ADAMTS10 18 NT5C1B 35 SCARB1 24 C19orf47 21 PCDHA6 19 FAM227B 18 ADCY1OP1 18 NT5C1B 33FCGBP 24 CALHM1 21 PSD3 19 FLJ12334 18 ALDH4A1 RDH14 33 RASGRF2 24 COX8C 21 PVWVP2B 19FTMT 18 ALDH9A1 18 OCA2 32 ATXN10 24 ID3 21 RAB40C 19 GLTSCR1 18ANO9 18OPCML 32 MAG12 24 LINGO3 21 USP53 19 GPR128 18 ARHGAP22 18 OR2AE1 32 RNF222 24 MYEOV 21 WDR27 19 HCG18 18 ARHGAP27 18 PBX1 31 B3GNTL1 24 PCDHA1 21 ZNF167 19 HNRNPA1L2 18 ARHGEF18 18 PDE9A 31 EPHA1-AS1 24 PCDHA2 20 ADAMTS2 19 HOXA3 18 BLCAP 18PDXDC1 31NRXN2 24PCDHA3 20ARHGEF10 19HYMAI 18 BOLL 18 PRKAR1B 31 PKHD1L1 24 PCDHA4 20 B3GALT6 19 IL16 18 C10orf47 18 PRSS50 31 RHBDF2 24 PLD3 20BRDT 19IRS2 18 C19orf35 18 QRSL1 31 SLC25A22 24 PPP2R2D 20 CCDC169- 19 KBTBD13 18 C6orf201 18 RAD51B 31 SNTG2 24 PRTN3 SOHLH2 19 KCNAB3 18 CDK2AP1 18 RBFOX1 31 SPRR2D 24 SLC25A24 20 CCDC88B 19 KIF26B 18 EFNA2 18 RLTPR 31 TSNAX-DISC1 24 TM4SF19- 20 CENPW 19 KRT36 18 EIF2AK4 18 RNU6-81 31 TTC7B TCTEX1D2 20 COL5A1 19LHCGR 18 EXOC2 18 RTN41P1 30 APOL6 24 TRIM10 20 CUX1 19 18 FAM170B 18 SAMD4A 30 MOB2 24 TRIM15 20 DIP2C LOC100128714 18 FAM217A 18 SCGB1C1 30 NFIC 24 UNC79 20 DYNC1LI1 19 18 FAM50B 18 SH3BP5L 30 PRDM15 23 ADAD2 20 GRASP LOC100133612 18 FARP1 18SPDYC 291NTS1 23 ATP1OA 20 HCG17 19 18 FIZ1 18SPERT 29LRP5 23BEX1 20KDM6B LOC100287834 18FKBPL 18SPRED3 29PXDNL 23 C15orf59 20 MAGEB1 19 18FOXP1 18SRGAP3 29 SLC6A19 23ESRRG 20 MIMT1 LOC100292680 18 FTHL17 18 STK10 29 SPECC1 23 ITIH1 20 NSUN7 19 LOC653160 18 GATA6 18 STK32C 29 TLR6 23 KCND2 20PACRG 19 LOC729121 18GGN 18 TAF7 28AGAP1 23 OSBPL5 20 PACRG-AS1 19 MAGEA12 18 GIMAP1 18TAPBP 28BMP3 23 PABPC1P2 20PCDHA7 19 MAGEB2 18 GPRC5A 18TBC1D1 28 CAMTA1 23 PLXND1 20PCDHA8 19 MRPL34 18 GPX6 18 TCEAL3 28 FEZ2 23 POMT2 20 PDZD2 19 MSH5- 18 GZF1 18 TMEM160 28 MIR54802 23 SLC9A3 20PEG3 SAPCD1 18 HDGFL1 18 TRIO 28 PRDM16 23 TAF1C 20 PFKFB3 19 NME8 18 HIST1H1T 18 TTC22 28PUM2 22 DNAJB6 20 PLEKHF1 19 NUBP2 18 HLA-DQB2 18TUBA3C 28 RPS6KA2 22 F10 20 PTPRD 19 OPRD1 18INPP5F 18TUBB 28 TMEM72-AS1 22 GALNTL5 20 RBFOX3 19 PCDHA10 18 JAKMIP3 18 VPS51 28 ZC3H12D 22 GIMAP1- 20 RECQL5 19 PCDHA9 18 JARID2 18 WDR25 27 AP5Z1 GIMAP5 20 SDF4 19 PLAGL1 18KRAS 18 WDR60 27 BLOC1S5- 22 MIR662 20 SENP3 19 PTRF 18 LGALS9C 18 WFDC1 TXNDC5 22 MSLN 20 SENP3-EIF4A1 19PXDN 18 LINC00482 18 WIPF1 27 HLA-A 22 NLRP14 20 SLC25A51P1 19 RAB32 18 18 WRAP73 27 ZC3H11A 22 QRICH2 20 SLC9C1 19 RELB LOC100506733 18 ZBTB22 26 ANO7 22 RAMP3 20 SOHLH2 19 RERE 18 LOC219731 18 ZNF100 26 BST2 22 RNU5D-1 20 TNKS2 19 RGPD4 18 LOC440700 18 ZNF354A 26 CSF1R 22 RNU5E-1 20TNNT3 19 SHANK2 18 LOC641367 18 ZNF74 26 GPR123 22 SMAP1 20 TXNDC15 19 SIGIRR 18 LOC653486 18 ZNF747 26 NDRG1 22 UTS2D 20 ZIM2 19 SLC5A6 18LRFN1 18 ZNF775 26 S100A9 21AHRR 20 ZNF579 19 SMAD6 18MACROD2 17 ACAP3 26TRABD 21 ASIC4 20 ZNF660 19 SPSB3 18 MAGEA10 17 ACOT4

17 ADAD1 17 LOC401010 17 SCARA5 16 APBA1 16 GAGE2E 16 MYT1L 17 ADARB2 17 LOC401242 17 SDK1 16 AR 16 GAGE8 16 NAALADL2 17 ADGB 17 LOC442028 17 SELT 16 ARHGEF17 16 GLB1L2 16 NAP1L5 17 AGAP3 17 LOC493754 17 SEMA3B 16 BCL2L2- 16 GL12 16 NEDD4L 17 AGFG1 17 LOC729176 17 SGK223 PABPN1 16 GML 16 NFIX 17 AGRN 17 LY9 17 SLC27A1 16 BCOR 16 GNAS 16 NOS1AP 17 ANKRD11 17 MAP7D1 17 SLMO1 16 BTBD19 16 GPR75 16 NOS3 17 ANKRD30A 17 MAPK8IP3 17 SMG6 16 C16orf7 16 GPR75-ASB3 16 NPHP3 17 ANO3 17 MGAT4C 17 SOAT2 16 C16orf9O 16 GREM2 16 NPHP3 17 ATP11A 17 MIR335 17 SOHLH1 16 C19orf25 16 GRWD1 ACAD11 17 BAIAP2L2 17 MIR4485 17 SPN 16 Clorf87 16 GTPBP3 16 NPHP3-AS1 17 BEND2 17 MXI1 17 ST20 16 C3orf45 16 HCG4B 16 NRSN1 17 BRCAl 17 MYOM2 17 ST20-MTHFS 16 C3orf77 16 HERC3 16 NTNG2 17 C11orf95 17 NGFRAP1 17 STAU2 16 C4orf22 16 HGC6.3 16 NYAP2 17 C1orf228 17 NOBOX 17 STK31 16 C5orf47 16 HHLA2 16 OXR1 17 Clorf6l 17 NPFFR2 17 SVIL 16 C6orf147 16 HIVEP2 16 P2RX4 17 C2 17 NR5A2 17 SYTL1 16 C7orf72 16 HMHA1 16 P2RY1 17 CAMK1D 17 OBSCN 17TENM4 16 CCDC130 16 HOOK2 16 PABPC3 17 CARD11 17 PCDHB16 17 TEX12 16 CCDC71L 16 IGDCC3 16 PABPN1 17 CCDC129 17 PCDHB7 17 TFAP2E 16 CCDC80 16 ITSN2 16 PAG1 17 CCDC79 17PCDHB8 17 TM7SF2 16 CDC14C 16 JAKMIP1 16 PAGE3 17 CCER1 17 PCDHB9 17 TMEM151A 16 CECR1 16 KCNB2 16 PCDHB17 17 CCNB3 17PCDHGA1 17TMUB1 16 CELSR3 16 KCNG2 16 PCSK4 17 CDKN3 17 PCDHGA10 17 TNFRSF18 16 CHORDC1 16 KCNQ1 16 PDE11A 17 CERS1 17 PCDHGA11 17 TNRC18 16 CLASP2 16 KCNQ1OT1 16 PDHA2 17 CHD7 17 PCDHGA12 17TNXB 16 CLEC4C 16 KIF13B 16 PGK2 17 CHST6 17PCDHGA2 17 TRIM50 16 CLK2P 16 KLHDC7B 16 PHLPP1 17 CRYL 17PCDHGA3 17 TTYH3 16 CLUAP1 16 KRBA1 16 PKIA 17 DCAF4 17PCDHGA4 17 TUBA3E 16 CNNM1 16LDHD 16 PLA2G4E 17 DDX3Y 17PCDHGA5 17 U2AF1L4 16 CNP 16 LFNG 16 PLVAP 17 DISC1 17PCDHGA6 17 UBE3B 16 CNTNAP1 16 LIG1 16 POM121L12 17 DMKN 17PCDHGA7 17 UGT1A10 16 COL11A2 16 LINC00221 16 POM121L9P 17 DNAH12 17PCDHGA8 17 UGT1A3 16 COL22A1 16 LINC00473 16 PON2 17 EEPD1 17PCDHGA9 17 UGT1A4 16 COL9A1 16 LINC00668 16 PPP1R18 17 EHMT2 17PCDHGB1 17 UGT1A5 16 CPE 16 LMTK3 16 PROKR1 17 ELMSAN1 17 PCDHGB2 17 UGT1A6 16 CT45A1 16 16 PRSS35 17 FAM58BP 17PCDHGB3 17 UGT1A7 16 CTAG2 LOC100128881 16 PRSS55 17 FAM9A 17 PCDHGB4 17 UGT1A8 16 CTNNA3 16 16 PSORS1C2 17 FASTK 17PCDHGB5 17 UGT1A9 16 CUX2 LOC100129794 16 RAB13 17 FKBP6 17 PCDHGB6 17 VPS37B 16 CXorf36 16 16 RASGEFlC 17FRMD1 17PCDHGB7 17 WDR88 16 DLG2 LOC100130581 16 RBM15B 17 GALNT14 17 PLEC 17 ZBTB7A 16 DMRTB1 16 16 RBPJ 17 GDF1 17 PLEKHG5 17 ZFPM1 16 DNAJA4 LOC100132831 16 REPIN1 17 GINS4 17 PNLDC1 17 ZNF282 16 DNAJB3 16 LOC255025 16 RFX1 17 GPR133 17PNMA1 17 ZNF469 16 DOK2 16 LOC340094 16 RNF220 17 GPR158 17 PPM1H 17 ZNF668 16 DPEP3 16 LOC389641 16 RNU6-71 17 GPR39 17 PPP1R13L 17 ZNF696 16 DPP6 16 LOC407835 16 RP1 17 GRIN2D 17 PPP1R2P9 17 ZNF764 16 DVL3 16 LOC619207 16 RPH3AL 17 H1FNT 17 PPT2 17 ZNF784 16 ELF5 16 LOC643441 16 RPL13 17 HLA-DQB1 17 PPT2-EGFL8 17 ZNF865 16 ERLIN2 16 LOC731789 16 RPS27 17 HSPA7 17PRDM9 17 ZSWIM4 16 ERO1L 16 LPCAT1 16 RPS6KA4 17 IFITM2 17PRNP 17 ZYX 16 FAM100A 16 LRFN3 16 RTN1 17IGFLR1 17 PRPS1L1 16 AATK 16 FAM197Y2 16 LRRC38 16 RYR2 17 IL18 17 PRRT1 16 ACE2 16 FAM197Y5 16 LRRIQ3 16 SALL3 17 KCNJ14 17PSENEN 16ACRC 16 FAM47A 16LRRTM3 16 SBK2 17KCNQ2 17 RABIF 16 ADARB1 16 FAM83A 16 MAD1Ll 16SDCCAG8 17 KCNT1 17 RAI1 16 AGAP2 16 FAM9B 16 MAGEB6 16 SEL1L2 17 KHDC1 17 RARG 16 AGBL4 16 FBXL18 16 MBD3 16 SELK 17 KIAA0513 17 RASA3 16 AHDC1 16 FHAD1 16 MCC1 16 SEPT9 17 KIAA2013 17 RBM11 16 AKAP12 16 FIGLA 16 MEX3A 16 SH2B2 17 KIFC1 17 RFESD 16 AKT3 16 FLJ42875 16 MIR1237 16 SH2B3 17 KRTAP5-4 17 RGS14 16 ANK1 16FPGT 16 MIR4648 16 SIM1 17 LINC00359 17 RGS7 16 ANKFY1 16 FPGT-TNN13K 16 MIR548F5 16 SIVAl 17 17 RIN3 16 ANKRD20A9P 16 FRAS1 16 MOB3C 16 SKI LOC100506122 17 RLBP1 16 ANKRD24 16 GAB1 16 MT1IP 16 SLC12A6 17 17 RNF113B 16 ANKRD33B 16 GAGE2A 16 MTMR1 16 SLC25A16 LOC100506229 17 RPS7 16AN08 16 GAGE2C 16 MUC4 16 SLC25A21 17 LOC116437 17 SBNO2 16 AP2M1 16 GAGE2D 16 MYO7B 16 SLC25A31

16 SL025A3P1 15 ABHD1 6B 15 DIS32 15 15 PDElA 15 TFAP4 16 SL02A5 15 ABR 15 DLGAP2 L001 00507584 15 PDXK 15 TGFB1 16 SLC30A8 15 ADNP2 15 DMRT02 15 15 PKD1 15 THBS4 16 SL044A2 15 ADORAl 15 D00K4 L001 00873065 15 PLEKHB1 15 TKTL1 16 SL08A3 15 AIPLi 15 DPPA2 15 L00153684 15 PODXL2 15 TMEM 132A 16 SMYD3 15 ALDH3B1 15 DUSP8 15 L0C255512 15 POLG 15 TMEM161A 16 SNAR-I 15 AMDHD2 15 DZIPi 15 L0C285577 15 POLR3A 15 TMEM237 16 SNX20 15 AMPD3 15 EEF1 El - 15 L0C646762 15 POU5F2 15 TMPRSS9 16 SORBS2 15 ANKRD2 MUTED 15 L0C728743 15 PP2D1 15 TOLLIP 16 SPTB 15ANKRD9 15 EGFR 15 L0C729080 15 PRELP 15 TOMM20L 16 SRD5A2 15 AP1 M2 15 EHD2 15 LPIN1 15 PRR5 15 TPD52L2 16 SSR4P1 15APC 15 EHD4 15LRBA 15 PRSS22 15 TRIM29 16 SSX7 15 APCDD1L 15 ENOPHi 15LRG1 15 R3HDM4 15 TRIM7 16 ST1 4 15APOE 15 EVL 15 LRP1 B 15 RAB40B 15TRPM4 16 STK11 15 ARAPi 15 FAM13C 15 LRRC72 15 RALBP1 15 TSPY2 16 STK3 15 ARHGEF2 15 FAM 172A 15 LT04S 15 RASAL3 15 TTC21 B 16 SY0E1 15 ARHGEF4 15 FAM 184B 15 LUZP4 15 RASIPi 15 TTC40 16 SYDE1 15 ART3 15 FAM221 A 15 LY6G60 15 RBM24 iSTUGi 16 SYTL3 15 ASB4 iSEHODi 15LYPD4 15 RBM44 15 UCKLi 16 TB01 Dl7 15 ATP6VO0 15 FLRT2 15 MAB21 L2 15 RBM45 15 UFSP2 16 T0TEX1 D2 15 ATP8A2 iSEMNi 15 MAEL 15 RBMS1 15 ULK3 16 T0TEX1 D4 15 B4GALT7 15 FMNL1 15 MAG 15 REX01 L2P 15 UNC13A 16 T0TN1 15 BASPi 15 FTLP1O0 15 MAGEB16 15 RFPL3-AS1 15 UNC80 16 TDRD1 2 15 B0L2L1 2 15EFZOS 15 MAGIX 15 RGL3 15 USP42 16 TEX1 4 15 BLO01 S5 15 GAB2 15 MANBAL 15 RGS1 2 15 USP6NL 16 TMEM140 15 BOD 1L2 15 GAB4 15 MAST4 15 RNF1 9B 15 WHS02 16 TMEM1 75 15 BRSK1 15 GABRB1 15 M0MD02 15 RNF39 15 XAGE3 16 TMEM247 15OClOorf7l 15 GAGE1 2F 15 ME3 15 RNU5F-1 15 YDJ0 16 TNFAIP8 150C14orf79 15 GAGE1 21 15 MGC2752 15 ROB01 15 ZBTB47 16 TNFRSF1 OA 150C2orf27A 15 GAGE4 15 MGC72080 15 RPS24 15 ZFHX4 16 TNFRSF25 150C3orf30 15SGAGES 1SMIR3065 15 RYRi 15 ZFYVE28 16 TNFSF12- 150C4orf47 15 GAGE7 15 MIR4695 15S100A1 3 15 ZNF19 TNFSF1 3 150C6orf25 15 GEMi 15 MIR4785 15 S1PR4 15 ZNF26 16 TNFSF1 3 150C9orf1 70 15 GGTL01 15 MIR548AP 15 SALL4 15 ZNF423 16 TRAPPC12 150CA0NA2D1 15 GNAS-AS1 15 MIR5703 15 SBF1 P1 15 ZNF628 16 TRPV2 150CA0NA2D4 15 GNG7 15 MMP1 3 15 S0AMP2 15 ZNF701 16 TSNAX 150ADM4 15 GPR146 15 MOB3A 15 SEMA6A 15 ZNF735 16 TSPY1 150CALML3 15 GPR25 15 M0R02 15 SETBP1 15 ZNF768 16 TSPY4 150CALML5 15 GRAMD2 15 MPHOSPH6 15 SLAIN2 15 ZNF787 16 TTTY23 150CAPS2 15 GSDMD 15 MR11 15 SL022A3 15 ZNF837 16 TTTY23B 150CBFA2T3 15 GSE1 15 MYEOV2 15 SL025A29 14 A0ER3 16 TUBA3D 150CBX4 15 HAPLN4 15 MY01iF 15 SL034A2 14 A00T1 1 16 TYK2 1500001 16 15 HEBP1 15 N4BP1 15 SL035D1 14 A0SF3 16 UBAP1 L 15SCCDC141 15 HHIPL1 15 N6AMT2 15 SL038A5 14 A0SL5 16 U0HL3 150000C880 15SHLA-L 15 NAFi 15 SLC6A1 6 14 ACTR8 16 UNC5B 150000C96 15SHLTF 15 NAT1 4 15 SL07A7 14 A0YP2 16 UN0SD 1500CRL2 15 HLTF-AS1 15 NBR2 15 SL03A1 14 ADAM1l8 16 USBi 150CDKL1 15 HNRPDL 15 NELF 15 SNORDi 16-11 14 ADAPi 16 VENTXP7 150CENPJ 15 HTR7P1 15 NFAT02 15 SNORD1 16-12 14 AD0Y9 16VVFIKKN1 150CGNL1 15 IFITM5 15 NIPA2 15 SNORDi 16-13 14 ADORA3 16 WNT5A 150CHD6 15 IGSF1 1 15 NMUR2 15 SNTG1 14 AEBP1 16 XIST 15CHDH 15 IGSF21 15 NOTCH3 15 SPATA1 3 14AGMO 16 XKR4 15 0HST1 1 15 IL22 15 N0T0H4 15 SPO1 1 14AHNAK 16 YBX1 15 0HST1 2 15IRAK2 15 NOVA2 15 SREBF1 14 AKAP 10 16 ZBTB70 15 0HST2 151RF3 15 NSUN4 15 SV2B 14 ALG1 16 Z03H8 1501ILP2 15 ITGAX 15 NTM 15 SY0P3 14 ALOX1 2 16 ZFP64 15 CPEBi 15 KATNAL2 15 NUBPL 15 TADA2B 14 ALPK1 16 ZGLP1 15 CRiL 15 K0NH5 15 NUDT9P1 15 TAF4 14 ALPK3 16 ZNF219 15 CXorf2l 15 K0NH8 15 NXN 15 TAS2R6O 14AMT 16 ZNF319 15 CXorf6l 15 KCNIPi 15 OASL 15 TBX6 14 ANKRD1 3B 16 ZNF354B 150CYB561 15 KIAA1875 15SOQEP 15 T0EAL6 14 16 ZNF365 150CYP4F2 15 KPRP 15 OSBP2 15 T0EB3B ANKRD2OA1 1P 16 ZNF384 150CYP4X1 15 KRT1 8P55 150SMR 15 T0EB30 14 AN02 16 ZNF444 15 CYTHi 15 KRT28 15PAOX 15 TCPl1 14 APBA2 16 ZNF611 15 DABi 1 iLCK 15 PARK2 15TDRD6 14APOBR 16 ZNF678 15 DAZL 15 LINC00340 15 PC iSTENM2 14 APTX 16 ZNF777 15 DEF6 15 15 P0DHB1 4 15 TES 14 ARHGEF1 9 16 ZS0AN1O0 15 DIRAS3 L00100129931 15 P0DHB6 15 TEX28 14 ARL40

14 ASPHD1 14 DLC1 14 HNRNPUL2- 14 MGARP 14 RAP1A 14 TPTE2P5 14 ATF6 14 DLEU7 BSCL2 14 MGC34034 14 RAP1GAP2 14 TRERF1 14 ATF71P 14 DLEU7-AS1 14 HOXA4 14 MGC3771 14 RAP2A 14 TREX1 14 ATOH7 14 DLK1 14 HRAS 14 MIR1225 14 RASSF8 14 TRIM2 14 AUTS2 14 DNAJC17 14 HS6ST1 14 MIR148A 14 RBM46 14 TRIM41 14 B3GNT6 14 DNM1L 14 IGF2BP1 14 MIR1973 14 RBM47 14 TRPV4 14 BCL11A 14 DOK6 14 IGSF9 14 MIR548W 14 RBMXL2 14 TSPAN17 14 BCLAF1 14 DPP9 14 IGSF9B 14 MIR618 14 REM2 14 TSPAN31 14 BMP8A 14 DPPA5 14 ILl7RA 14 MMP28 14 RHBDF1 14 TSPAN32 14 BRAF 14 DSCR4 14 IL21R 14 MMP9 14 RIPK4 14 TSPYL5 14 BRCA2 14 DSCR8 14 INSL6 14 MON1B 14 RNF103- 14 TSPYL6 14 BR13 14 DTX1 14 INSR 14 MRC2 CHMP3 14 TXNDC12 14 BSCL2 14 DUSP21 14 IQCG 14 MRPL55 14 RPL13AP3 14 UGT1A1 14 BTBD2 14 EBF1 14 ITGB2 14 MSH4 14 RPL6 14 UHRF1BP1L 14 C10orf32- 14 ECE1 14 ITGB5 14 MS12 14 RREB1 14 VIPR1 AS3MT 14 EEF1DP3 14 ITPRIPL2 14 MSRA 14 RRP1B 14 VPREB1 14 C10orf76 14 EFCAB9 14 KCND3 14 MTMR14 14 RWDD3 14 VSIG2 14 C11orf21 14 EHMT1 14 KCNK3 14 MYADML 14 RXRA 14 VWA7 14 C12orf5 14 ELAVL4 14 KCNV2 14 MY016 14 SCRN2 14 WDR69 14 C13orf45 14 EMD 14 KDM2B 14 NBEAL2 14 SDPR 14 WTAPP1 14 C15orf38 14 ERCC2 14 KDM4B 14 NCOR2 14 SELM 14 YPEL4 14 C15orf38- 14 ESC02 14 KIF2B 14 NDUFA11 14 SEMA6B 14 ZAR1L AP3S2 14 ESPNP 14 KLK15 14 NEIL1 14 SERF2- 14 ZC3H12C 14 C15orf62 14 EVPL 14 KRTAP17-1 14 NFATC1 C150RF63 14 ZFP42 14 C15orf63 14 FAM122C 14 KRTAP19-5 14 NFATC4 14 SERINC4 14 ZFP92 14 C17orf98 14 FAM155A 14 KT112 14 NHP2 14 SERPINE1 14 ZFPM2 14 C1QTNF7 14 FAM3A 14 L3MBTL1 14 NHSL2 14 SEZ6L2 14 ZFY 14 C2orf74 14 FAM46D 14 LAMA4 14 NICN1 14 SH3TC1 14 ZNF18 14 CAPN3 14 FAM47C 14 LCOR 14 NID1 14 SHMT1 14 ZNF205 14 CARHSP1 14 FAM53A 14 LIN7A 14 NOD2 14 SLC17A9 14 ZNF217 14 CASP2 14 FAM57B 14 LINC00226 14 NRXN1 14 SLC22A18 14 ZNF311 14 CATSPER2 14 FAM83B 14 LINC00351 14 NYX 14 SLC22A31 14 ZNF467 14 CCDC117 14 FAM83H 14 LINC00588 14 ORA13 14 SLC25A2 14 ZNF524 14 CCDC162P 14FANCF 14 LINC00674 14 OSCAR 14 SLC6A8 14 ZNF589 14 CCDC17 14 FBXL19 14 14 PAPOLB 14 SMOC2 14 ZNF648 14 CCDC25 14FCH02 LOC100131094 14 PARP4 14 SNX8 14 ZNF665 14 CD7 14 FHIT 14 14 PAX8 14 SOCS5 14 ZNF688 14 CDH11 14FHOD3 LOC100286922 14 PBX2 14 SPACAl 14 ZNF689 14 CDH23 14 FLJ46906 14 14 PCDHB4 14 SPG21 14 ZNF718 14 CDX1 14 FLNA LOC100287704 14 PEBP4 14 SP11 14 ZNF77 14 CETN1 14 FOXK1 14 14 PER3 14 SPON1 14 ZNRD1-AS1 14 CHCHD6 14 GABRQ LOC100506451 14 PHYHIP 14 SPSB4 14 ZPBP 14 CHURC1- 14 GAK 14 14 PIGH 14 SPTBN5 14 ZSCAN5A FNTB 14 GAL3ST1 LOC100506713 14 PITPNM1 14SRRM2 13 AAED1 14 CKLF-CMTM1 14 GALE 14 LOC283692 14 PWIL2 14 SRRM2-AS1 13 ACBD3 14 CLDN10 14 GAS7 14 LOC284100 14 PLCB2 14SRRM4 13 ACTL9 14 CLDN18 14 GGT7 14 LOC285441 14 PLCH1 14 SSX21P 13 ADAM19 14 CLN3 14 GLUL 14 LOC285501 14 PLEKHA5 14 STX11 13ADAM8 14 CMIP 14 GNG13 14 LOC286094 14 POU2AF1 14 STYX 13 ADAMTS17 14 CMTM1 14 GNG3 14 LOC339803 14 PPAP2C 14 SUGT1P3 13 ADRBK1 14 CORO1B 14 GPR143 14 LOC339894 14 PPCDC 14 SYCE1L 13 ADSSL1 14 CPN1 14 GPR160 14 LOC643406 14 PRICKLE2 14 SYN1 13 AFAP1 14 CRH 14 GPR20 14 LOC644649 14 PRKCH 14 SYNE2 13 AGER 14 CSMD2 14 GPR4 14 LOC654433 14 PRR12 14 TAF5 13 AGPAT4 14 CST9 14 GPRC5C 14LOXHD1 14 PRR23A 14 TAGLN2 13 AGTR1 14 CTAGE1 14 GPRIN1 14 LRFN2 14 PRR5- 14 TCEAL4 13 AJAP1 14 CTNNB1 14 GPSM2 14 LRRC56 ARHGAP8 14 TDGF1 13 ALOX5AP 14 CTPS1 14 GRIN3B 14LRRC7 14 PRSS41 14 TECTA 13 ANKAR 14 CUL4B 14 GRK7 14 LRRC73 14 PTDSS2 14 TEF 13 ANTXR2 14 CXCL9 14 GTDC1 14 LST1 14 PTGDR2 14 TEX264 13 AP3B2 14 DAPK1 14 GUCY2D 14 LTB 14 PTK6 14 TKTL2 13 APBB2 14 DCLK2 14 HCN1 14 LTBP4 14 PTPRE 14 TMEM132B 13 APC2 14 DDX1 14 HEXB 14 MAFK 14 PVRL4 14 TMEM132C 13 ARID3A 14 DGKD 14 HIPK2 14 MAGEL2 14 PVT1 14 TMEM139 13 ARL2 14 14 HIST1H3A 14 MATN4 14 RAB27A 14 TMEM151B 13 ARL2-SNX15 DKFZp566F0947 14 HLA-J 14 MBD1 14 RAB37 14 TMEM56- 13 ARPC2 14 14 HLCS 14 MCM5 14 RAC1 RWDD3 13 ASAP3 DKFZp68601327 14 HMG20B 14 MEX3D 14 RADIL 14 TOP2B 13 ASB16

13 ASCL2 13 CLCA4 13 FFAR1 13 KBTBD5 13 MC1R 13 PEG10 13 ASIC1 13 CLCN6 13 FKRP 13 KCNA1 13 MCF2L 13 PEL11 13ASPDH 13 CLEC16A 13 FLJ39653 13 KCNH2 13 MCF2L2 13 PES1 13 ASPG 13 CLIP2 13 FNTB 13 KCNK4 13 MESDC1 13 PFN3 13 ASPH 13 CNDP2 13FOXN4 13 KCNMB2 13 MEX3B 13 PIK3CG 13 ATG5 13 CNR2 13 FOX03B 13 KEAP1 13 MFSD6L 13 PIK3R6 13 ATP1A1 13 COL6A4P2 13 FOXR1 13 KIAA0528 13 MGC16121 13 PKD2L2 13 ATP6V1C1 13 COL9A3 13 FRMD4A 13 KIAA1522 13 MIB2 13 PKDREJ 13AURKC 13 COX412 13 FRMD8 13 KIF16B 13 MINK1 13 PLA2G16 13 BA12 13 COX7B2 13FRMPD4 13 KIF23 13 MIR1204 13 PLCL2 13 BCAR1 13 CPLX1 13 FZD1 13 KIF3B 13 MIR1224 13 PLIN5 13BCKDK 13 CPLX2 13 GABBR1 13 KIF3C 13 MIR1256 13 POLR3G 13BCMO1 13 CPPED1 13 GAGE10 13 KIF5B 13 MIR196A1 13POMC 13BGN 13 CRTAC1 13 GALNT5 13 KLF15 13 MIR223 13 PON3 13 BHMT2 13 CSDE1 13 GALNT9 13 KLF8 13 MIR23A 13 POTEA 13 BLOC1Si- 13 CTAGE7P 13 GCFC2 13 KLHDC5 13 MIR24-2 13 POTEF RDH5 13 CTBP2 13 GCSAML-AS1 13 KLHDC7A 13 MIR27A 13 PPARD 13 BMP2 13 CUEDC1 13 GDF9 13 KLHL36 13 MIR371B 13 PPP1R13B 13 BNIPL 13 CXXC1 13 GHDC 13 KRT83 13 MIR372 13 PPP1R2P3 13 BOLA3 13 CYB5R3 13 GK2 13 L3MBTL4 13 MIR373 13 PROX1 13 BOLA3-AS1 13 CYP26C1 13 GNPDA1 13 LANCL2 13 MIR4750 13 PRR25 13 BRE 13 CYR61 13 GPC2 13 LGALS9 13 MIR542 13 PRSS42 13 BRE-AS1 13 DCAF4L1 13 GPR45 13LGR6 13 MMP23A 13PSMA8 13 BTBD11 13 DCAF4L2 13 GPR68 13 LIMCH1 13 MMP23B 13 PTPRQ 13 ClOorf118 13 DCAF8L1 13 GPR97 13 LIMK1 13 MRGPRE 13 R3HCC1L 13 ClOorf32 13 DCP1B 13 GRIN2B 13 LINCO0301 13 MRPS6 13 RAB11FIP1 13 C11orf2O 13 DCTN4 13 GRTP1 13 LINC00332 13 MSTO2P 13 RAB40AL 13 C11orf67 13 DDAH1 13 GTF2B 13 LINC00346 13 MTHFD2 13 RABGAP1L 13 C12orf4O 13DDC 13 GYS1 13 LINC00379 13 MTSS1 13 RAD52 13 C15orf43 13 DDX11 13 H2BFWT 13 LINC00629 13 MXRA8 13 RARB 13 C17orf65 13 DDX43 13 HAUS7 13 LINC00637 13 MYBPC2 13 RASALl 13 C1QTNF4 13 DDX53 13 HBS1L 13 13 MYH14 13 RB1 13 Clorf145 13 DLEU2 13 HDLBP LOC100289673 13 MYO1H 13 RBKS 13 C1orf146 13DMGDH 13 HEATR7A 13 13 MYO7A 13 RBM8A 13 C1orf56 13 DNAJC15 13 HIST1H1A LOC100506994 13 N4BP2L1 13 RBP4 13 C22orf45 13 DND1 13 HIST1H2BH 13 13 NAT8L 13 RBPJL 13 C2orf65 13 DNHD1 13 HIST1H4A LOC100507266 13NCAM1 13 RCC1 13 C3orf14 13 DNLZ 13 HIST1H4G 13 13 NCK2 13 RCCD1 13 C8orf4O 13 DOK7 13 HIST3H3 LOC100507377 13 NDNF 13 RDH5 13 C9orf47 13 DRD5 13 HLA-DPB1 13 13 NECAB1 13 RELL1 13 C9orf69 13 E2F7 13 HLA-F LOC100507463 13 NEIL2 13 RHOXF1 13 CACNA1A 13 EFCAB10 13 HMGCL 13 13 NEU1 13 RHOXF2 13CACNG6 13 ELAVL3 13 HMGCLL1 LOC100996291 13 NEURL3 13 RHOXF2B 13CADM2 13 ELF2 13 HNF4A 13 LOC148696 13NGDN 13 RIBC2 13 CAMSAP3 13 ELK2AP 13 HNRNPC 13 LOC282980 13 NGFR 13 RNF103 13 CAMTA2 13 ELTD1 13 HOXA-AS3 13 LOC284454 13 NKAIN3 13 ROBO2 13 CAPG 13 EMC10 13 HOXC4 13 LOC284998 13 NLRP11 13 RORA 13 CARD9 13 EMILIN1 13 HPCAL1 13 LOC285768 13 NLRP4 13 RPL17 13 CASZ1 13 EMP1 13 HSH2D 13 LOC387723 13 NR3C1 C180RF32 13 CBX6 13 EP400NL 13 HSPBP1 13 LOC643339 13 NR4A3 13RPRM 13 CCDC74B-AS1 13 EPHA8 131CAl 13 LOC644669 13 NRBF2 13 RSF1 13 CCNB1 13 EPHX4 13 ICAlL 13 LOC84856 13 NTSR2 13 RUNX1 13 CCR10 13 ERRF11 13 ICAM3 13LPAR3 13 NUCB1 13 RUNX3 13 CCZ1 13 EXOC6B 13 IKZF4 13 LPCAT2 13 ONECUT3 13 S1O0A1 13 CCZ1B 13 F2RL3 13 IL18BP 13 LRP8 13 OPLAH 13 S100B 13 CD151 13 FAM125B 13 ILlRAPL2 13 LRRC37BP1 13 OPRK1 13 S1PR1 13 CD300LF 13 FAM136A 13 IL411 13LRRC4B 13 OR2C3 13 S1PR3 13 CD47 13 FAM171A2 13 IL5RA 13 LY6K 13 OXCT1 13 SBK1 13CDC14B 13FAM47B 13INCENP 13 LY86 13PAGE2B 13SCAF1 13 CDCA3 13 FAM48B1 13INF2 13 MAATS1 13 PARD3 13 SCNN1A 13 CDH12 13 FAM49B 13INPP4A 13 MAGEA1 13 PCDHA11 13 SECTM1 13 CDR2L 13 FAM71E1 13IQCE 13 MAGED2 13 PCDHB15 13 SEL1L3 13 CELF6 13FANCC 13 ITGA4 13 MALL 13 PCDHB3 13 SEMA5A 13 CEP85L 13 FBLN7 13 ITGA6 13 MAN1C1 13 PCDHGB8P 13 SERPINAl 13 CERS3 13 FBRSL1 13 ITIH5 13 MAP3K11 13 PCSK2 13 SH2D3A 13 CHRNA10 13 FBXL7 13JAK2 13 MAP3K6 13 PDE4D 13 SH3BP2 13 CHST13 13 FBXW8 13JPH3 13 MBLAC2 13 PDE8B 13 SH3BP5 13 CIITA 13 FEZ1 13 KAZALD1 13 MBTPS1 13 PDS5B 13 SH3D21

13 SH3PXD2A 13 TTTY4 12 ALDH3A1 12 C2CD2 12 CNNM2 12 EZH1 13 SH3RF3 13 TTTY4B 12 ALOX5 12 C2orf27B 12 COASY 12 FA2H 13 SH3RF3-AS1 13 TTTY4C 12 ALOXE3 12 C3orf67 12 COL16A1 12 FAM11OB 13 SHANK3 13 TUBB3 12 ANG 12 C5orf42 12 COL18A1 12 FAM170A 13 SHISA2 13 TULP2 12 ANGEL2 12 C5orf58 12 COL27A1 12 FAM183B 13 SKP2 13 TXLNB 12 ANGPT2 12 C6orf15 12 COL2A1 12 FAM189A1 13 SLC12A9 13TXNRD2 12ANKMY1 12 C7orf45 12 COL4A2 12 FAM20B 13 SLCl5Al 13 UBE2U 12 ANKRD30BL 12 C8orf22 12 COL6A6 12 FAM48B2 13 SLC16A9 13 UNC5A 12 ANKRD31 12 C8orf44-SGK3 12 CRBN 12 FAM9C 13 SLC20A2 13 UNC93B1 12 ANKRD34B 12 C8orf46 12 CREB3L1 12 FAT1 13 SLC22A18AS 13 UPB1 12 AP4S1 12 C9orf4O 12 CROCCP3 12 FBLIM1 13 SLC25A37 13UQCRQ 12 APCDD1 12 CA14 12 CRSP8P 12 FBXL16 13 SLC25A45 13 USP29 12 APLNR 12 CACNA1H 12 CSNK1AlL 12 FBXL8 13 SLC43A2 13 USP5 12 APOA5 12 CACNB1 12 CTAGE11P 12 FBXO17 13 SLC44A4 13 USP7 12APOB 12 CACNG2 12 CTNNA2 12 FBXO21 13 SLC4A3 13 VGLL4 12 APOBEC3AB 12 CALHM3 12 CTSO 12FCAMR 13 SLC52A3 13 VT11A 12 ARFRP1 12 CALML4 12 CUL1 12FERMT3 13 SLC5A3 13 VWA5B2 12 ARHGAP4 12 CAPNS1 12 CX3CR1 12 FGFR1 13 SLC6A2 13 WBP2NL 12 ARHGEF25 12 CASP5 12 CYB5R2 12 FIBCD1 13 SLCO6A1 13 WDR24 12 ARHGEF33 12 CASP7 12 CYP46A1 12 FIGNL1 13 SMAD3 13 WDR43 12 ARHGEF9 12 CAV1 12 CYTH4 12 FIS1 13 SMARCD1 13 WDR65 12 ARID5A 12 CCDC11 12 DACH1 12 FKBP5 13 SMC1B 13 WIZ 12 ARMCX5- 12 CCDC112 12 DACT1 12 FLII 13 SMYD4 13 WNT7A GPRASP2 12 CCDC115 12 DCAF6 12 FLJ25363 13 SNAR-H 13 WRNIP1 12 ARNT2 12 CCDC144B 12 DCC 12 FLJ25758 13 SNRPD1 13 ZBTB12 12 AS3MT 12 CCDC155 12 DCTN2 12 FLJ30403 13SNRPN 13 ZBTB16 12 ASB2 12 CCDC172 12 DDX11-AS1 12 FLJ42289 13 SNX25 13 ZBTB20 12 ASPSCR1 12 CCDC177 12 DDX54 12 FLJ42627 13 SNX29 13 ZBTB20-AS1 12 ATF71P2 12 CCDC27 12 DENND3 12 FLJ45974 13 SOGA3 13 ZCCHC13 12 ATG7 12 CCDC33 12 DLGAP1 12 FNDC1 13 SOX30 13 ZFHX3 12 ATP2A3 12 CCDC36 12 DMAP1 12 FOPNL 13 SPAG7 13 ZMIZ1 12 ATP6AP1L 12 CCDC73 12 DNAH6 12 FSD1L 13 SPRED2 13ZMYND8 12 ATRIP 12 CCDC8 12 DNAL11 12 FSTL1 13 SPTBN4 13 ZNF213 12 ATXN3 12 CCKBR 12 DNM3 12 FXYD2 13 SSBP2 13 ZNF275 12 ATXN7L1 12 CCT3 12 DNM3OS 12 FXYD6-FXYD2 13 SSBP3 13 ZNF286A 12 B4GALNT3 12 CCT6A 12 DOCK9 12 G3BP2 13 STAG3 13 ZNF286B 12 BAIAP2 12 CD300LG 12DOHH 12 GABRA5 13 STK32A 13 ZNF324B 12 BAIAP2-AS1 12 CD58 12 DOM3Z 12 GAGE12B 13 SUV420H1 13 ZNF366 12 BCAS3 12 CDC25A 12 DTWD1 12 GAGE12C 13 TAP2 13 ZNF385A 12 BCCIP 12 CDC42BPB 12 DUOX1 12 GAGE12D 13TCN2 13 ZNF438 12 BFAR 12 CDH18 12 DUSP2 12 GAGE12E 13TDRD1 13 ZNF517 12 BIRC8 12 CDH5 12 DYM 12 GAGE12G 13TENM3 13 ZNF521 12 BLOC1lS 12 CDH6 12 DYNC1L12 12 GAGE12H 13 TEX101 13 ZNF532 12 BNIP2 12 CDIPT 12 DYSF 12 GALNT2 13 TEX13A 13 ZNF653 12 BNIP3 12 CDK12 12 E2F6 12 GAN 13 TFDP1 13 ZNF672 12 BOLA1 12 CDK19 12 EBNA1BP2 12 GAPDH 13 TFF2 13 ZNF746 12 BPI 12 CEACAM21 12 EBPL 12 GATA2 13 TGIF2LX 13 ZNF786 12 BRD1 12 CENPF 12 ECEL1P2 12 GATM 13TGM5 13 ZNF853 12 BRSK2 12 CEP120 12 ECHDC1 12 GCK 13 THSD7B 12 ABCA13 12 BVES 12 CEP170 12 EGFLAM 12 GEMIN5 13TMC1 12 ABCA7 12 BVES-AS1 12 CFDP1 12 EIF4E2 12 GGACT 13 TMEM173 12 ABHD12 12 C11orf49 12 CHMP6 12 ELANE 12 GIP 13 TMEM229B 12 ABLIM2 12 C11orf54 12 CHODL 12 ELF4 12 GJA5 13 TNFAIP8L2- 12 ACER2 12 C12orf75 12 CHRM4 12 ELOVL2 12 GJA8 SCNM1 12 ACIN1 12 C14orf162 12 CHRNB3 12 ELOVL2-AS1 12 GJB1 13 TNFRSF1A 12 ACTL7B 12 C14orf28 12 CHST15 12 ELOVL7 12 GJD3 13 TP73 12 ACTN1 12 C15orf60 12 CIT 12 ELP6 12 GLIS1 13TPM4 12 ADAT3 12 C17orfllO 12 CKLF 12 EML4 12 GMCL1P1 13 TRAPPC10 12 ADCY8 12 C17orf97 12 CLCF1 12 ENPEP 12 GNA14 13 TRIM27 12 AFF3 12 C19orf66 12 CLDN4 12 EPCAM 12 GNA15 13 TRIM43 12AGA 12 Clorf101 12 CLDN9 12 ERBB21P 12 GORASP2 13 TRIM5 12 AGBL5 12 Clorfl06 12 CLHC1 12 EREG 12 GPATCH8 13 TRIM62 12 AICDA 12 Clorfl59 12 CLIC1 12 ESPNL 12 GPR108 13 TRIP6 12 AIFM1 12 Clorfl77 12 CLIC3 12 ESRRB 12 GPR112 13TRPM2 12 AIP 12 C1orf204 12 CLIC6 12 ETV6 12 GPR132 13 TSKS 12 AKNA 12 C1orf65 12 CLP1 12 EVPLL 12 GPRASP2 13 TTC38 12 AKR1E2 12 C1orf85 12 CLTB 12 EXOC8 12 GPT 13 TTLL11 12 ALDHlA3 12 C22orf43 12 CLYBL 12 EYA2 12 GRB10

12 GRK5 12 KIF13A 12 LOC400794 12 MXRA7 12 PPFIA3 12 SH2D3C 12 GRM4 12 KIF5A 12 LOC440356 12 MYH9 12 PPIG 12 SH2D4B 12 GSPT1 12 KIF6 12 LOC441601 12 MYL7 12 PPM1N 12 SH2D7 12 GUSBP11 12 KIF7 12 LOC63930 12 MYL9 12 PPP1CC 12 SHARPIN 12 HAPLN1 12 KIRREL3 12 LOC729177 12 MYLK-AS1 12 PPP1R11 12 SHFM1 12 HECW1 12 KLF13 12 LOC90834 12 MYO3A 12 PPP1R12B 12 SIGLEC15 12 HERC2 12 KLF17 12 LOX 12 MYO9B 12 PPP1R16A 12 SLA 12 HIBCH 12 KLF6 12 LPPR3 12 MYOM3 12 PPP1R36 12 SLC12A4 12 HIST1H2AA 12 KLHL17 12 LPPR5 12 NAIF1 12 PPP2R3C 12 SLC13A4 12 HIST1H2BA 12 KLHL21 12 LRP12 12 NBEA 12 PRAM1 12 SLC17A7 12 HIVEP1 12 KLHL25 12LRTM2 12 NCALD 12 PRKACA 12 SLC22A16 12 HLA-DOA 12 KLHL33 12LRTOMT 12NCDN 12 PRMT2 12 SLC22A4 12 HLA-DQA2 12 KLK4 12 LTBP3 12 NCKAP5 12 PRMT8 12 SLC25A25 12 HLA-G 12 L3MBTL3 12 LTBR 12 NCOA2 12 PRSS3 12 SLC25A48 12 HLA-H 12 LAG3 12 LY86-AS1 12 NDRG3 12 PSD 12 SLC2A1 12 HMCN1 12 LAIR1 12LYSMD2 12 NECAP1 12 PSEN2 12 SLC2A14 12 HMGN3 12 LBX2 12 MAB21L1 12 NEDD1 12 PSKH1 12 SLC35C1 12 HOMER3 12 LBX2-AS1 12 MAGEA4 12 NEK3 12 PSME1 12 SLC35F3 12 HOXB-AS3 12 LIMS2 12 MAMSTR 12 NFIA 12 PSTK 12 SLC37A1 12 HOXC5 12 LINCO0029 12 MAOB 12 NGLY1 12 PSTPIP1 12 SLC38A10 12 HOXC6 12 LINCO0032 12 MAP3K5 12 NIPAl 12 PTCHD3 12 SLC3A1 12 HRASLS 12 LINCO0460 12 MAP7D2 12 NKX6-3 12 PTPLB 12 SLC45A2 12 HRH1 12 LINC00474 12 MAPKAPK2 12 NOC2L 12 PTPN4 12 SLC47A2 12 HS3ST1 12 LINC00477 12 MARK2 12NONO 12 PTPRA 12 SLC6A11 12 HSF2BP 12 LINC00577 12 MARK4 12 NPAS1 12 PTPRH 12 SLC9A3R1 12 ICAM2 12 LINC00606 12 MBP 12NRGN 12 PUS7L 12 SLC9A9 12 ID02 12 LMNB2 12 MC3R 12 OBFC1 12 QPCT 12 SLFN5 12 IL17RE 12LMO2 12 MCHR1 12 OPHN1 12 RAB15 12 SLPI 12 IL17REL 12 12 MCM3AP 12 OR1OQ1 12 RAB33A 12 SMARCA2 12 IL21R-AS1 LOC100128993 12 MCPH1 12 OR8U8 12 RAB3C 12 SMEK3P 12IMP4 12 12 MDGAl 12 OR9Q2 12 RAB7A 12 SMPDL3B 12INPP5D LOC100129520 12 ME11 12 ORA1l 12 RAPGEFL1 12 SNED1 12IQSEC1 12 12 MESP2 12 OSBPL3 12 RASGEFlA 12 SNIP1 12IQSEC3 LOC100129620 12 MFAP4 12 OTUD3 12 RASGEF1B 12 SNORA14B 12IRAK4 12 12 MGC2889 12 OXSM 12 RASSF2 12 SNORD123 12IRF2 LOC100129917 12 MGMT 12 OXT 12 RAVER1 12 SNORD58A 12IRF5 12 12 MGRN1 12 PACSIN1 12 RBCK1 12 SNORD58B 12 IRGQ LOC100130776 12 MIA3 12 PAGE2 12 RBM25 12 SNORD58C 12IRS1 12 12 MIR143HG 12 PAGE 12 RBM6 12 SNORD73A 12 ISCU LOC100130872 12 MIR145 12 PALD1 12 RBPMS 12 SNORD93 12 ISM1 12 12 MIR199A2 12 PANX2 12 RCBTB2 12 SNX16 12ISPD LOC100130987 12 MIR2110 12 PARN 12 REREP3 12 SOGAl 12 ITFG3 12 12 MIR4426 12 PART1 12 RFPL4B 12 SPATA16 12 ITGA7 LOC100131089 12 MIR4499 12 PBK 12 RIN1 12 SPATA2 12 ITGB2-AS1 12 12 MIR4656 12 PCGF3 12 RIN2 12 SPON2 12 ITGBL1 LOC100131496 12 MIR5001 12 PCNXL2 12 RNASE4 12 SPRTN 12 IZUMO1 12 12 MIR5093 12 PDE3A 12 RNF17 12 SRPK3 12JAK3 LOC100131551 12 MIR516B2 12 PDE7B 12 RNF213 12 SRSF5 12 JAZF1 12 12 MIR520G 12 PDLIM4 12 RPL17 12 SSX3 12JMJD8 LOC100131726 12 MIR548AA2 12 PDLIM7 12 RPP25 12 STARD3NL 12 KBTBD8 12 12 MIR548D2 12PEMT 12 RPS27A 12 STK19 12 KCNG1 LOC100144597 12 MIR596 12PGRMC1 12 RPS3A 12 SUMF2 12 KCNIP2 12 12 MIR602 12 PHF14 12 RPS6KL1 12 SUZ12P1 12 KCNIP3 LOC100288198 12 MKNK1 12 PHF16 12 RRAD 12 SYN2 12 KCNQ1DN 12 12 MKRN2 12 PIM1 12 RSPH1 12 SYNGR2 12 KCTD10 LOC100289187 12 MKX 12 PINX1 12 RTN2 12 SYNJ2 12 KCTD5 12 12 MLC1 12 PION 12 SAE1 12 SYNPR 12 KDM6A LOC100294145 12 MLK7-AS1 12 PIP5K1P1 12 SART3 12 SYNPR-AS1 12 KHDC3L 12 12 MLX 12 PITPNM2 12 SCAMP4 12 SYS1 12 KIAA0226 LOC100505806 12 MMADHC 12 PWILl 12 SCML4 12 SYS1-DBNDD2 12 KIAA0319L 12 12 MOK 12 PLA2G4D 12 SCTR 12 TAF1D 12 KIAA0391 LOC100507433 12 MOV10L1 12 PLCD3 12 SCYLl 12 TBC1D4 12 KIAA0753 12 LOC145663 12 MPHOSPH8 12 PLEKHA6 12 SEC14L1 12 TBC1D9B 12 KIAA0922 12 LOC220906 12 MPST 12 PLEKHH3 12 SENP5 12 TBKBP1 12 KIAA1383 12 LOC283683 12 MR1 12 PLXNB3 12 SERHL2 12TECR 12 KIAA1429 12 LOC284661 12 MRPL22 12 PNMA5 12 SESN2 12 TET1 12 KIAA1549 12 LOC375196 12 MSH5 12 PNPLA6 12 SETDB1 12 TFEB 12 KIDINS220 12 LOC400043 12 MTHFR 12 PNPT1 12SGCE 12 TG

12THEGL 12 YJEFN3 11 AQP2 11 CBR4 11 DOCK8 11 GGNBP1 12 THTPA 12 ZADH2 11 ARHGAP26 11 CBX5 11 DPM1 11 GJA9 12 TIGD1 12 ZBTB7B 11 ARHGEF1OL 11 CBX7 11 DPP4 11 GJA9-MYCBP 12 TIMM13 12 ZC3H12A 11 ARPC1B 11 CCBP2 11 DUS4L 11 GLRA1 12 TIMP4 12 ZC3H3 11 ASB8 11 CCDC107 11 DYNC2H1 11 GLUD1P3 12 TIPIN 12ZCCHC7 11ASCC2 11 CCDC146 11EDAR 11 GNPNAT1 12 TLL2 12 ZDHHC14 11 ASIC3 11 CCDC50 11 EHHADH 11 GP6 12TM2D3 12ZEB2 11ASNAl 11CCNJL 11EIF3J 11GPR12 12 TMEM190 12 ZFHX2 11 ATAT1 11 CD44 11 EIF4A3 11 GPR157 12 TMEM200B 12 ZFYVE26 11 ATMIN 11 CD52 11 ELL 11 GPR77 12 TMEM209 12 ZG16B 11ATOH8 11 CD6 11 ELOVL4 11 GPSM1 12 TMEM51 12 ZGPAT 11 ATP2C2 11 CDC42EP4 11 EML6 11 GPX3 12TMEM9 12 ZHX1 11 ATP5D 11 CDCP2 11ENG 11GRAMD3 12 TNFRSF11A 12 ZHX1- 11 ATP5J2 11 CDH2 11 EPDR1 11 GRAP2 12TNFRSF8 C80RF76 11ATP5J2- 11CDK20 11EPHA4 11GRHL2 12 TNFSF11 12 ZNF101 PTCD1 11 CES1P1 11 EPM2AIP1 11 GRIK4 12 TNK1 12 ZNF195 11 ATP6VOD1 11 CHD5 11 EPRS 11 GRIN3A 12TNPO3 12 ZNF200 11 ATP6V1B1 11 CHD9 11 ERGIC1 11 GRK4 12 TOMM20 12 ZNF251 11 ATP8B2 11 CHGA 11 ER13 11 GSPT2 12 TOR3A 12 ZNF259 11ATXN8OS 11 CHRNB2 11 ERO1LB 11 GTF3C3 12 TPO 12 ZNF277 11 AVPR1B 11 CHST3 11 EXOC3 11 GTF3C4 12TRADD 12 ZNF280A 11 B9D1 11CHTOP 11EXOSC1 11 GTPBP1 12 TRIM14 12 ZNF32 11 BAK1 11 CKAP2 11EXOSC2 11 GUCY1B2 12 TRIM43B 12 ZNF32-AS3 11 BCAT1 11 CLDN6 11 EXOSC3 11 GULP1 12 TRIM65 12 ZNF341 11 BCDIN3D 11 CLK2 11 EXOSC6 11 GXYLT1 12 TSACC 12 ZNF354C 11 BDKRB1 11 CLPB 11 EZR 11 GYG2 12 TSC22D4 12 ZNF385C 11 BEND4 11 CMYA5 11 F7 11 HCGl 12 TSHZ1 12 ZNF396 11 BID 11 CNFN 11 FABP7 11 HCG22 12 TST 12 ZNF428 11 BIN2 11 CNNM4 11 FAIM3 11 HCN3 12 TTC39A 12 ZNF461 11 BLK 11 COG5 11 FAM188A 11 HDAC7 12 TTLL7 12 ZNF527 11 BMP6 11 COL20A1 11 FAM18A 11 HDGF 12 TUBA8 12 ZNF540 11 BMP8B 11 COMMD7 11 FAM195A 11 HEATR8-TTC4 12 TUBB8 12 ZNF542 11 BMS1P4 11 CORO1C 11 FAM19A2 11 HELLS 12TUBGCP2 12 ZNF555 11 BOC 11 COX6C 11 FAM208A 11 HELZ2 12 TXLNA 12 ZNF576 11 BRAT1 11 COX7C 11 FAM222A 11 HIGDlA 12 UBA7 12 ZNF599 11 BRD4 11 CPEB3 11 FAM222A-AS1 11 HILPDA 12 UBAC2 12 ZNF622 11 BRF1 11 CPNE7 11 FAM5C 11 HIST1H1D 12 UBE2DNL 12 ZNF782 11 BTBD3 11 CREB3L3 11 FBXO15 11 HIST1H4F 12 UBE2MP1 12 ZNF785 11 BTK 11 CRTC3 11 FBXO46 11 HLA-DMB 12 UBQLN1 12 ZNF831 11 BUB1B 11 CSDC2 11 FBXO47 11 HLX 12UBXN2B 12ZNRD1 11BZRAP1 11CSNK1G3 11FCHO1 11HMG20A 12 UCHL1 12 ZSCAN18 11 BZRAP1-AS1 11 CST6 11FERMT1 11 HMHB1 12 UCK2 11AARD 11 ClOorf1l 11 CTBS 11 FLJ13197 11 HNMT 12 ULK2 11AARS 11 ClOorf9O 11 CTDSPL 11 FLJ20518 11 HNRNPA1 12UROS 11ABCB8 11 C16orf45 11 CUL4A 11 FLJ27354 11 HNRNPA1P10 12 USP1 11 ABCC1 11 C16orf74 11 CXCL12 11 FLJ35946 11 HOMER1 12 USP18 11 ABCC3 11 C16orf91 11 CXXC5 11 FMR1NB 11HORMAD1 12 USP45 11 ACAA2 11 C17orf64 11 CYB5B 11 FNBP1 11 HOXA2 12 UXS1 11 ACTR1A 11 C18orfl 11 CYP2E1 11 FOXA2 11 HOXB2 12 VAMP3 11 ADAM2 11 C19orf38 11 DAXX 11 FOXK2 11 HOXB3 12 VCX 11 ADAMTS4 11 C19orf43 11 DAZAP2 11 FOXL2 11 HOXB6 12 VPS13D 11 ADAMTSL3 11 C1QTNF3- 11 DCAF12L2 11FOXRED2 11 HSPA6 12 VSIG8 11 AGXT2L2 AMACR 11 DCAF16 11FRG2C 11 HSPB9 12 VWC2L 11 AHNAK2 11 C1QTNF8 11 DD11 11 FSD2 11 HTR3A 12VWDE 11 AK7 11 C20orf197 11 DDX25 11 FUZ 11 HTR3E 12VVWF 11 AKAP7 11C2CD4C 11 DDX31 11 FZR1 11 HUS1B 12 WAC 11 ALDH1Ll 11 C2orfl8 11 DDX4 11 GABRB3 11 IER5 12 WARS 11 ALOX12P2 11 C3orf72 11 DEDD 11 GABRD 11 IFT140 12 WARS2 11AMACR 11 C3orf74 11DEDD2 11 GABRP 11 IL17RC 12 WBP1L 11 AMIGO2 11 C5orf49 11 DEF8 11 GAGE12J 11 IL28B 12 WNK2 11 AMIGO3 11 C5orf55 11 DEFB1 11 GAS5 11 ING2 12 WNT6 11 AMMECR1L 11 C6orf136 11 DENNDlA 11 GBA 11 INTS6 12 WRB 11 ANK2 11 C8orf42 11 DENND1C 11 GBE1 11 ISLR2 12 WTIP 11 ANKRD45 11 C8orf76 11 DERL1 11 GBF1 11 ISOC1 12 XP04 11ANKRD7 11 C9orf66 11 DHX58 11 GCOM1 11 ITGAL 12 XRCC5 11 ANP32C 11 CACNG8 11 DLL3 11 GDF5 11 ITPK1 12 YBEY 11 AP2A1 11CAMKMT 11 DNAJC27 11 GEMIN8P4 11 JAK1 12 YIF1B 11 AQP10 11 CAV2 11 DNAJC27-AS1 11 GFOD1 11 KALRN

11 KANK4 11 MAGEA2B 11 OR6B2 11 RBMXL3 11 SNORD78 11 TPGS1 11 KAT2A 11 MAMDC2 11 OSBPL7 11 RBMY1F 11 SNORD79 11 TPTE 11 KCNC1 11 MAP1LC3B2 11 PABPN1L 11 RCVRN 11 SNORD80 11 TRIB1 11 KCNN3 11 MAP3K12 11 PACS1 11 RFC1 11 SNORD81 11 TRIM42 11KHDRBS1 11 MAP3K14 11 PALM 11 RGMB 11 SNX18 11 TRMT10C 11 KIAA1211 11 MAP7 11 PAQR4 11 RGN 11 SP140L 11 TRPC5 11 KIAA1211L 11 MARCH1 11 PARP11 11 RGS20 11 SPA17 11 TSHZ3 11 KIAA1598 11 MARCH10 11 PATL1 11 RHOB 11 SPAG16 11 TTC39B 11 KIF19 11 MDFI 11 PCDH19 11 RHOH 11 SPATA3 11 UBE2G1 11 KLF11 11 MED25 11 PCDHA12 11 RHOU 11 SPESP1 11 UBE2H 11 KLF3 11 MEGF6 11 PCDHA13 11 RNF123 11 SPG7 11 UBN2 11 KLHDC2 11 METTL20 11 PCDHB13 11 ROR2 11 SPOCD1 11 UBXN11 11 KLHL1 11 MION 11 PDGFD 11 RORC 11 SPOCK3 11 UCN3 11 KRBOX1 11 MINPP1 11PDGFRB 11 RP1-177G6.2 11SPTSSB 11 USP35 11KREMEN2 11 MIPEPP3 11 PEAK 11 RPL22 11SRC 11 VGLL3 11 KRT16P3 11 MIR1297 11 PER2 11 RPL31P11 11 SRPRB 11 VPS36 11 KRT81 11 MIR1468 11 PET112 11 RPS6KA1 11SRRT 11 VTRNA2-1 11 KRTAP2-1 11 MIR150 11PGBD5 11 RRN3P2 11SRY 11 VWA3B 11 LAMTOR1 11 MIR1976 11PHAX 11 RTN4 11 ST7 11VWCE 11 LILRB1 11 MIR3607 11 PID1 11 SOA8 11 ST7-AS2 11 WDFY3 11 LIN9 11 MIR4633 11 PITX2 11 SAP30BP 11 STAB1 11 WDFY3-AS2 11 LINCO0511 11 MIR4710 11 PITX3 11 SASH3 11 STAP2 11 WHAMM 11 LINC00523 11 MIR548H4 11 PKN1 11 SCARF2 11 STK24 11 WNT10B 11 LIPK 11 MIR5680 11 PLA2G3 11 SCN4B 11 STRA8 11 XK 11 LMAN1L 11 MIR615 11PLEKHA7 11 SCNM1 11STRN3 11 XRCC3 11LMLN 11 MIXL1 11 PLEKHF2 11 SCNN1D 11 STX1B 11 ZBTB11 11LMO4 11 MKS1 11 PLOD1 11 SDCBP 11 SULT1C4 11 ZBTB37 11 11 MLH1 11 PLXNC1 11 SDR16C5 11 SUSSD5 11 ZC3H14 LOC100009676 11 MOB3B 11 PML 11 SEC62 11 SYCN 11 ZCCHC16 11 11 MOCS3 11 PNMA2 11SEMA3G 11SYNC 11 ZDHHC16 LOC100128164 11 MORN1 11 PODNL1 11SEPSECS 11SYNGR3 11 ZFX 11 11 MPND 11 POLR2M 11 SERPINB5 11SYNPO2 11 ZFX-AS1 LOC100132111 11 MRPL4 11 POU2F2 11 SERPINE2 11TACR1 11 ZMIZ2 11 11 MRPS17 11PPDPF 11 SERPING1 11 TAF3 11 ZNF131 LOC100271702 11 MRPS22 11 PPFIBP2 11 SFRP4 11 TBC1D14 11 ZNF232 11 11 MST1R 11PPM1G 11SGCB 11 TBX22 11 ZNF239 LOC100506207 11 MTF1 11 PPP1R9A 11 SGK3 11 TCF7L1 11 ZNF326 11 11 MTL5 11 PPP3R2 11 SGOL1 11TCTN3 11 ZNF470 LOC100507384 11 MTMR7 11 PRAME 11 SH3BP4 11 TDRD10 11 ZNF496 11 11 MUC21 11 PRAP1 11 SH3TC2 11TDRKH 11 ZNF549 LOC100507424 11 MYCBP 11 PRDMl 11 SHE 11TEAD3 11 ZNF610 11 LOC150185 11 MYH13 11 PREPL 11 SIAE 11 TEX10 11 ZNF716 11 LOC283688 11 MYLK2 11 PRKCDBP 11 SIM2 11 TFB1M 11 ZNF772 11 LOC283731 11 N4BP3 11 PRKCE 11 SIRPB2 11TFDP3 11 ZNF850 11 LOC284688 11 NAA11 11 PRL 11 SIX2 11TGFA 11 ZNF862 11 LOC284837 11 NACA2 11 PRMT7 11 SKIL 11 TIMP2 11 ZNHIT6 11 LOC285540 11 NAT2 11 PROP1 11 SLC19A1 11 TIPARP 11ZSCAN21 11 LOC286177 11NCAPG 11 PRRT4 11 SLC1A5 11 TIPARP-AS1 10ABIl 11 LOC286467 11 NDUFS2 11 PSMB2 11 SLC22A8 11 TLE2 10 ACTB 11 LOC339166 11 NECAB3 11 PTCH1 11 SLC25A18 11 TMC6 10 ADI1 11 LOC339524 11 NEK10 11 PTGIS 11 SLC26A6 11 TMC8 10 AFF1 11 LOC348120 11 NFAM1 11 PTPLAD1 11 SLC35B3 11 TMEFF2 10 AGBL3 11 LOC348761 11 NFE2L2 11 PTPRO 11 SLC38A9 11 TMEM108 10 AGRP 11 LOC389247 11 NIM1 11 PTPRR 11 SLC39A11 11 TMEM119 10 ANK3 11 LOC645212 11 NIPSNAP1 11 PTPRU 11 SLC39A12 11 TMEM179 10 ANKRD17 11 LOC648691 11 NKD1 11 PUS3 11 SLC46A1 11 TMEM204 10 ANKRD26P1 11 LOC727982 11 NOL4 11 PXDC1 11 SLC52A2 11 TMEM249 10 ANKRD33 11 LPAR5 11 NOP14 11 PYGO1 11 SLC5A10 11 TMEM44-AS1 10 AP1B1 11 LPIN2 11 NOX5 11PYROXD2 11 SLC5A11 11 TMEM63A 10 APOBEC3B 11LRCH2 11 NPAS3 11 R3HDML 11 SLC6A12 11TMEM71 10 APOBEC3H 11 LRIG1 11 NPNT 11 RAB17 11 SLCO5A1 11TMOD2 10 APOL2 11 LRPPRC 11 NRIP2 11 RAB25 11 SLIT1 11 TNFAIP2 10 ARHGEF26 11LRRC8C 11NSMCE1 11 RAB41 11 SLIT3 11 TNFRSF12A 10 ARHGEF26 11 LYPLA1 11 NTF3 11 RAD51C 11 SLITRK5 11 TNS3 AS1 11 LYSMD1 11 NUDT4 11 RAD54L2 11 SMIMi 11TOMM7 10 ARHGEF28 11 LZTFL1 11 NUDT4P1 11RARA 11SMTN 11 TOP1MT 10 ARID5B 11 MAF 11NUMAl 11 RASL10A 11 SNORD44 11 TP73-AS1 10ARX 11 MAGEA2 11 OMA1 11 RBM33 11 SNORD47 11 TPD52L3 10 ATP5F1

10OATP5G2 100DNAJA2 1OKONMB3 10ONUAK2 10SC02 10 TTC34 10OB3GALT5 100DNAJO5G 10KHK 10OAT 10OSO~l 10OTYMP 10 B3GALTL 10 OOKi1 10 KIAA0586 10 OBSL1 10SOHO 10 UBE2E1 10 B3GAT2 1000OK3 10 KIAA0895L 1000DF2L 10 S0K2 10 UBE21 10 B4GALT1 10ODOTiL 10 KRT1 7 100OR8H2 10 SENP7 10UQOC 10BOLl0 100DPYSL4 10 LAMB3 100OR02 10 SERP2 10OUSHiG 10 BFSP2 10 EFOAB5 10LAMO3 10 OSTOPi 10SHROOM2 10 USP22 10 BNIP3L 10 EIF2B3 10 LAMi 10 OTOP2 10 SIRTi 10 USP6 10OBSTi 10OEIF2O1 10 LINC00240 100OTU06A 10OSLO16A3 10OUSP9X 10OBTB01 10OEIES 10 LINC00607 10OPAOS2 10 SL025A3 10OVOX3A 10OCllorf87 10 EME2 10 LINC00652 10PARVG 10 SL025A4 10 VENTXP1 10OCllorf92 10OENOSFi 1OLMNB1 10PAWR 10 SL026A5 1OVKORO1 10OCllorf93 10OEPHB3 1OLM01 10OPOTP 10OSLO34A1 10 WBSCR27 10OCl7orflO9 10OEPSiS5Li 10 1OP0E1 B 10 SL035A3 10 WDR18 10OClorfll14 10OERBB4 L001 00131626 10OP0E6B 10OSLO35G1 10 WDR76 10OClorfl7O 10OESRP2 10 10OPOGEB 10 SL038A2 10 WDR77 10OClorfl73 10OEX01 L001 00216546 10PDYN 10 SL038A7 lOXPO 10OClorfS3 10OEXOO3L1 10 10 P0Z07 10 SL044A3 10OYIPF4 100C3orf37 10 F12 L001 00270804 10PENK 10OSLO4A2 1OZFAN04 100C3orf38 10OFAM171B 10 10OPGPEP1 10OSLO7A4 10OZEAT 100C4BPA 10OFAM176A L001 00287944 10OPGPEP1 L 10OSLO8A2 10OZIM3 100CA6 10OFAM182B 10 10OPHO2 10SLMAP 10OZNF1 69 10OCA0PS 10 FAM59B L001 00505549 10 PHL0A2 10 SMOcl 10 ZNF238 10OCALML6 10 FAM83G 10 10 PIP5K1A 10 SNORA38 10 ZNF300P1 100CAN02 10FANCG L001 00505622 10 PLEKHG3 10SNRK 10 ZNF37A 100CAPN12 10OFBN2 10 10OPOM121C 10SNRPE 10OZNF451 100CAR06 10FOER2 L00100506710 10 POSTN 10SOISi 10 ZNF586 100CASR 10OFIGN 10 10OPPAP2B 10OSOXio 10OZNF609 10OCAV3 10 FITMi LOC1l00653515 10 PPARA 10SPi 10 9 A00Y3 100000C48 10 FLJ34503 10 L0C255167 10 PPP2R5B 10 SP140 9 ADHEEl 100000C53 10 FOLH1 10 L0C375295 10 PRMT6 10 SPAG4 9 ANKR01O0 100000C86 10FOXR2 10 L0C389705 10 PROSi 10 SPAMi 9 ARHGAP31 10OCHORi 10 FUN0O2P2 10 L0C646329 10 PRRO2A 10 SSX6 9 ARL4A 1000CR6 10 GAS2L3 10 L0C646999 10 PS04 10 STARD1 0 9 ATL2 1000D247 10OGATA4 10 L0C731223 10OPTH2R 10OSTARD5 9 ATP9A 10000C37 10OGATSL3 10OLPP 10OPTPN1 8 10OSULTi El 9 ATXN1 1000DH4 10OGBX1 1OLRGUK 10OPTPN6 10 SUS03 9 BOL11 B 1000DH7 10OGOAPi 1OLSM3 10OPTPRJ 10OSUZ12 9 BEX2 1000DK4 10 G0P02 10OLTBP2 10OPTPRN 10 SV20 9BHMT 10OCDK5 10OGEMI N8 10OMAPKAPK3 10OPYOR2 10SYNM 9Cl 7orfl 01 100CEOR7 10OGIP~l 10OMAPRE2 10ORABli1B 10OSYT3 90C2orf61 100CELF2 10OGJA3 10OMAROH9 10ORAB5A 10OTAF2 90C6orf58 100CGGBP1 10OGLOD5 10OMOMlo 10 RAD21 10TAGAP 90C6orf7 100CHRM1 10OGLYATL3 10OMDMi 10 RAD21 -AS 1 10TARS 90C7orf23 10OCILP 10 GNA1 1 10 MEAPi 10 RALGPS2 10 TARSL2 90C9orf43 100CNGA4 10OGPHN 10 MFS5012 10ORAMP2 10 TB010D12 9OCAONA1 E 10OCNRi 10 GPIHBP1 10 MFS06 10 RAMP2-AS1 10 TCF12 90CA0NA202 1000OL4A1 10OGPR1 14 10OMIR3150B 10ORASAL2 10OTCF19 90CAD 1000OPS2 10 GPR1 24 10 M1R3615 10 RASAL2-AS1 10 TOEL5 9 CANTi 100CPNE5 10OGPR1 37B 10OMI R548AN 10ORBMY1 J 10OTEADi 900D22 10CRCP 10OGPR50 10 MIR561 10OREO8 10OTFAP20 900D28 100CRX 10OGRIK5 10 MIR661 10OREX02 10OTFE3 90CD79B 10CRYM 10OGRIN2A 10 MIR675 1ORFVVO3 1OTGM2 900HR5 10OCRYM-ASi 10 GUOY2GP 10 MMRN2 10 RFX4 10THRAP3 9005SN 1005S 10 H19 10OMPRIP 10ORNF111 10OTIMM21 9OCHSY1 100CT45A6 10OHEATR8 10OMpZ 10ORP9P 10OTIMM9 90CR2 10OCTNNBI P1 10HEOW2 10 MRPS28 10 RPA4 10 TMEM1 78B 9OCRBi 10OCTR9 10 HOXA5 10 MRPS34 10 RPL36A 10 TMEM74 9OCRIMi 10OCTSW 10 HS3ST3B1 10 MSGN1 10 RPL36A- 10 TNK2 9OYGB 100CYB5610D1 10 HS017B7 10 MTFMT HNRNPH2 10 TORiB 90DLG4 10OCYP26B1 10 HTR2O 10 MY01l5A 10 RSPH3 10TPON2 9DM0 100DAPK3 10 IL19 10OMYZAP 10ORYK 1OTRAPPO9 90DMRT2 10 DOSTAMP 10 IL4R 10 N0UFB4 10 S1OA10 10TREH 90NMBP 10OODRi 10OINHA 10ONEK9 10Osloop 10OTREML2 90DNMT3A 100DDX27 101POll 10 NINJ2 10 SAGEl 10 TRITi 9 EFHA1 100DIAPH2 10OKAT6A 10ONIT2 10 SAM01 4 10OTSPY3 9 EHBP1 100DLX6-AS1 10 KONA3 10 NME3 10SOMH1 10 TTC24 9 EX03 100DNAH1 7 10OKONABi 10ONRL 10OSON9A 10 TTC33 9 FAM 134B

9 FGF14 9 PPIEL 8 ARID3B 8 EML5 8 LOC284023 8 RPS4X 9 FGF14-AS2 9 PPP2CA 8ARVCF 8 ENO4 8 LOC338799 8 RTDR1 9 FGF14-IT1 9PRCD 8 ATG16L2 8 EP400 8 LOC339822 8 SAP25 9 FGF17 9 PRDX2 8 ATP1GB 8 EPB41L5 8 LOC643401 8SAPCD1 9 FKBP4 9 PRKD2 8ATP5G1 8EPHA7 8 LPP-AS2 8 SCAI 9 FLYWCH2 9 PRPF31 8 AXL 8 ERG 8LRCH4 8 SCD 9FSCN1 9PRR23C 8 BAG2 8 EXOC3L2 8 LRRC1 8SEPT1 9 FXYD1 9 PSMC1 8 BCL2L10 8 FAM111A 8LYPD6B 8 SERINC5 9FXYD7 9 RANBP17 8 BCL3 8 FAM129A 8 MACF1 8 SET 9GDNF 9 RHBDL2 8BHLHB9 8 FAM219A 8 MAG12-AS3 8 SFSWAP 9 GET4 9 RNASEH2A 8 COorfl05 8 FAM81A 8 MAML3 8 SLAIN 9 GRK6 9 RNF157 8 C11orf80 8 FAM96A 8 MAP2K3 8 SLC12A8 9 GTSF1 9 RNF2 8 C12orf23 8FAT3 8 MAPK10 8 SLC22A20 9 HEXIM2 9 RPTOR 8 C17orf6l 8FBLN1 8 METTL14 8SLC6A6 9 HIBADH 9 RRP1 8 Cl7orf6l- 8FEMlA 8 MFI2 8SLC7A2 9 HIST1H3E 9 RUFY1 PLSCR3 8 FLJ43860 8 MIR130B 8SMAD7 9IDS 9 SARS 8 Clorfl58 8 FRMD4B 8 MIR26A2 8 SNCG 9 KIAA1804 9 SBF2 8 C1orf233 8 FTL 8 MIR301B 8 SNX1 9 KIAA2022 9 SCT 8 C1orf52 8 FUT4 8 MIR4534 8 SORL1 9 KIF1C 9 SEC23B 8 C20orf26 8 GAL3ST3 8 MIR589 8SPATA21 9 KLHL6 9 SEMA5B 8 C3orf52 8GC 8 MPC1L 8STARD8 9 KLK1 9SERGEF 8 C6orfl23 8 GFPT1 8 MRPL9 8TACR3 9 KLK8 9SHROOM3 8 CACNA1C 8 GL13 8 MRPS9 8TADA3 9 KLK9 9 SLC18A2 8 CACNA1F 8GLOD4 8MSANTD1 8TCEA2 9 KRT73 9 SLC4A11 8 CAMK2B 8 GMCL1 8NAGLU 8TCEB3CL 9 LAMC2 9 SLC6A7 8 CCDC164 8GNG12 8 NAV2 8 TEX26-AS1 9 LAT 9 SLITRK2 8 CCDC22 8 GPR85 8NCAPG2 8THOC2 9 LDHAL6B 9 SLMO2 8 CCDC81 8 GPRIN3 8NECAP2 8THRA 9LEMD2 9 SLMO2-ATP5E 8 CCDC82 8 HIST1H2AC 8NLGN2 8THSD7A 9 LG14 9 SMARCA5 8 CCDC85A 8 HIST1H2BC 8NLRP3 8TLR5 9 LIMD1 9SNURF 8CCM2 8 HMOX2 8 NOSTRIN 8 TM4SF19 9 LOC100132215 9 SPATC1 8 CCN12 8HNRNPM 8 NOX4 8TMC04 9 LOC339975 9 ST18 8CCSAP 8 HOTTIP 8 NPY1R 8 TMEM105 9 LOC494141 9SUMO3 8 CCT4 8 HOXA13 8NTPCR 8 TMEM135 9 LOC646278 9 TBR1 8 CD164 8 HOXA6 8 NUS1 8 TMEM14C 9 LONRF2 9 TCIRG1 8 CDH10 8 IBA57 8 OAZ3 8 TNFAIP8L3 9 LTB4R 9 TCL1B 8 CDK10 8 IL28RA 8 OPA3 8TNFRSF1B 9 MAGT1 9 TFPT 8CDON 8 IL6R 8PARD3B 8 TNFRSF21 9 MAML2 9 TKT 8CENPBD1 8INCAl 8 PCDHB19P 8TOX 9 MAP3K10 9TMC7 8 CHAF1B 8 ING1 8 PDLIM3 8 TP53113 9 MAST1 9 TONSL 8 CHEK1 8INPP5B 8 PF4V1 8TPCN1 9 MBTPS2 9 TRAF31P3 8 CHKB-CPT1B 8 IPCEF1 8PFKFB2 8 TRAF31P2 9 MCOLN1 9 TRMT1GA 8 CHSY3 8IRF2BPL 8 PGAM1 8 TRAF31P2-AS1 9 MELK 9 TRPS1 8 CIDEB 81RF7 8PGLYRP2 8 TRAM1L1 9 METTL16 9 VCL 8CLEC2L 8JRKL 8PHACTR1 8 TRIM36 9 METTL22 9 VPS28 8CMAHP 8KANK2 8 PIP4K2A 8 TRIM51GP 9 METTL9 9 VRK2 8CMTM2 8 KAT6B 8 PLD1 8 TRIM61 9 MGST1 9 WNT5B 8 COL23A1 8 KCNE1L 8PLEKHH1 8 TRIML1 9 MIR219-2 9 WWTR1 8COPE 8KCNMAl 8 PLIN4 8TRPC3 9 MIR2964A 9 ZBTB17 8 CPT1B 8 KIAA0146 8 PMF1-BGLAP 8TSPAN10 9 MIR320E 9 ZC3HC1 8 CRELD2 8 KIF1A 8 POLR21 8TSPAN11 9 MIR371A 9 ZNF268 8 CRISPLD2 8 KRT85 8PPP2R2C 8 UBE2D2 9 MIR55A1 9 ZNF358 8 CRNKL1 8 KTN1 8PPP3CC 8 UCN 9 MN1 9 ZNF575 8 CSF2 8 KTN1-AS1 8PRKCZ 8 UMODL1 9 MTTP 9 ZNRF2 8CTDSP2 8LATS2 8PRKDC 8 UNC13B 9 MUC2 8 ABHD14A 8 DAB2 8 LEF1-AS1 8 PROSAPIP1 8VAMP8 9 MYO1E 8 ABHD14A- 8DCHS1 8LEFTY1 8PSKH2 8VASH1 9 MYO1G ACY1 8 DDX11L2 8 LINCO0441 8 QRFP 8VHL 9 NDST4 8 ABHD14B 8 DDX19B 8 LINCO0620 8 RAB36 8 VPS13B 9 NDUFA12 8 ACVR1B 8 DDX49 8 LINCO0640 8RASD1 8 VSIG4 9 NDUFS8 8 ADAM30 8DGUOK 8 LINCO0643 8RCOR2 8VSTM5 9 NPSR1 8 ADAMTS19 8 DISP2 8 LIPH 8 RHOBTB1 8 WDR13 9 OSM 8ADCY2 8DLG5 8 LOC100144603 8RHOF 8 WWP2 9 OTX1 8 ADRA2A 8 DNA11 8 LOC100631378 8 RIT2 8YOD1 9 PASK 8 AFG3L1P 8 DNMBP-AS1 8 LOC100861402 8 RNMTL1 8 ZNF267 9 PGGT1B 8 AGBL1 8EBAG9 8 LOC100996307 8RNPEP 8 ZNF48 9PKM 8 ALS2CR11 8 EBF2 8 LOC254312 8 RPL1GL 8 ZNF503 9 POLE3 8AMN 8 EHBP1Li 8 LOC257358 8 RPL31 8 ZNF503-AS2

8 ZNF516 7 CD164L2 7 FECH 7 KIAA1984-AS1 7 MTMR3 7 RUSC1-AS1 8 ZNF556 7 CD36 7 FEV 7 KLHL15 7 MX2 7 S100A2 8 ZNF564 7 CD4 7 FGD2 7 LAMP3 7 MXRA5 7 S100Z 8ZNF679 7CDC42EP1 7FL11 7LCN10 7MYO5C 7SCRT2 8 ZNF697 7 CDH9 7 FLJ33534 7 LDHC 7 NACAP1 7 SDF2 8ZSCAN20 7 CDHR1 7 FLJ36000 7 LEF1 7NAGK 7 SEC61A2 7 ABCB6 7 CDK18 7 FLJ46257 7 LIG4 7 NAPEPLD 7 SEMA4G 7 ABHD13 7 CEP104 7 FLRT3 7 LIN54 7 NCOA4 7 SFXN3 7 ACP1 7 CERK 7 FN3K 7 LINCO0092 7 NDUFB10 7 SGK2 7 ADAMTS1 7 CHL1 7 FOXF1 7 LINC00200 7 NLRC4 7SGSM3 7 ADCK5 7 CHST9 7 FOXF1-AS1 7 LINC00642 7 NLRP1 7 SH3YL1 7 AIF1 7 CHURC1 7 FOX11 7 LMX1B 7 NPAP1 7 SHISA9 7 ALDH5A1 7 CIAO1 7FTCD 7 LOC100128593 7 NPM2 7 SIAH3 7 ALOX15P1 7 CLDN15 7 FUCA2 7 LOC100129138 7 NPR2 7 SIGLEC17P 7 ALS2CL 7 CLPSL2 7 FZD8 7 LOC100130950 7NRG1 7 SIX5 7 AMZ1 7 COL4A5 7 G6PD 7 LOC100130992 7 NRP1 7 SLC10A4 7ANKLE1 7 COL4A6 7GALNTL2 7 LOC100505738 7 NRTN 7SLC16A14 7 ANKLE2 7 CPA1 7 GDE1 7 LOC100506178 7 NRXN3 7 SLC26A9 7 ANKRD44 7 CPT1A 7 GDPD5 7 LOC150568 7 NSA2 7 SLC28A2 7 AP2A2 7 CRIP2 7 GF11 7 LOC339529 7 NSMCE2 7 SLC35C2 7APOA2 7CROCC 7GFM2 7LOC340357 7NTNG1 7SLC37A4 7 AQP1 7 CRYBA4 7 GINS2 7 LOC374443 7 NUP210 7 SLC39A10 7ARPP21 7 CRYBB1 7GLRX2 7 LOC400685 7 NUP21OL 7SLC9B2 7ASNS 7CRYBG3 7GLT25D1 7LOC729506 7NXT2 7SMCR7 7 ASZ1 7 CSF3 7GMFG 7LRRC4 7 OGT 7 SMPD3 7 ATG9A 7 CXCL10 7 GNB4 7LSM6 7 OSR1 7 SMURF1 7 ATL3 7 CXCR2 7 GPC5 7 LSP1 7 OVOLl 7 SND1 7 ATP1B4 7 CXCR5 7 GPLD1 7 LTB4R2 7 PAX7 7 SNHG12 7 AZU1 7 CYSTM1 7 GPR56 7 LTBP1 7 PCDHB5 7 SNORA16A 7 BICD1 7 DACT2 7 GPR78 7 LYN 7 PHF20 7 SOCS7 7 BIRC5 7 DBT 7 GRID21P 7 LYNX1 7 PHLDB3 7 SPHK1 7 BRD2 7 DCAF12L1 7 GSC 7 MADCAM1 7 PIK3R2 7 SPIB 7 BTNL2 7 DCTPP1 7 GSTCD 7 MAEA 7 PIPSL 7 SPIN2A 7 ClOorfl07 7 DCUN1D4 7 GUCA2A 7 MAGEB18 7 PITPNC1 7 SPNS3 7 C10orf114 7 DDX50 7 GUCY1B3 7 MAG11 7 PNKD 7 SPTBN2 7 C11orf58 7 DENND2D 7 GUCY2C 7 MANEAL 7 PNPLA1 7 SSPO 7 C11orf63 7 DFFB 7 H6PD 7 MARS 7 PPAN-P2RY11 7 SSTR4 7 Cl6orfl1 7DGKZ 7 HAUS4 7 MED31 7 PPP1R16B 7 ST8SIA6 7 C17orf28 7 DHX15 7 HAVCR2 7 MEF2B 7 PPP1R1B 7 STARD3 7 C19orf55 7 DNASE1L1 7 HDGFRP2 7 MEF2BNB- 7 PPP1R7 7 STEAP3 7 C19orf59 7 DUPD1 7 HEY2 MEF2B 7PRDM8 7 SUN1 7 C19orf6 7 DUSP6 7 HIC2 7 METTL5 7 PRSS57 7 SUPT6H 7 C1QTNF2 7 ECE2 7 HMSD 7 MFHAS1 7 PSMB7 7 SYBU 7 C1QTNF9 7 EFHC2 7 HOXA10 7 MF12-AS1 7PSMD4 7 TAF8 7 C22orf32 7 EIF3D 7 HOXA10- 7 MGST2 7 PSORS1C3 7 TAOK3 7 C3orf55 7 EIF4G1 HOXA9 7 MICAL3 7 PTDSS1 7 TAZ 7 C4orf36 7 ELK4 7 HOXB5 7 MICALL2 7 PTK2B 7 TBC1D2B 7 C6orf195 7 ELMO1 7 HSBP1 7 MIR1276 7 PTPN21 7 TBC1D9 7 C8orf48 7 ELMO3 7 HSPA12B 7 MIR143 7 PTPN23 7 TBL1X 7 CA12 7EMB 7 HSPA2 7 MIR1915 7 PUS10 7 TCL1A 7 CALB1 7 EML1 7 IFF02 7 MIR3136 7 PUS7 7 TEX26 7 CALCB 7 EPHAl 7IKBKG 7 MIR3545 7 PYY 7 TEX30 7 CALR 7 EPHAl0 7 IL12RB1 7 MIR4458 7 QSER1 7TFDP2 7 CAMK2G 7 EPN1 7 ILRN 7 MIR4520B 7 RABL6 7 THBS1 7 CAPN8 7 ER11 7 IL20RA 7 MIR4707 7 RAVER2 7 TMBIM4 7 CARD10 7 ESYT2 7 IL2RB 7 MIR4801 7 RCSD1 7 TMEM101 7 CASKIN1 7 EXOC3L4 7 INS-IGF2 7 MIR5187 7RGR 7 TMEM127 7 CASP10 7 EXOSC7 7INTS12 7 MIR608 7 RLF 7 TMEM242 7 CCDC136 7 EXOSC9 7IRF2BP1 7 MIR609 7 RLIM 7 TMEM26 7 CCDC142 7 EYA3 7 ITGA3 7 MK1671P 7 RLN1 7 TMEM30B 7 CCDC144NL 7 FAM109B 7 KCNC2 7 MLLT1 7 RNF212 7TMF1 7 CCDC85C 7 FAM173B 7 KCTD12 7 MLXIP 7 RNF6 7 TNF 7CCNC 7 FAM18B2 7 KCTD2 7 MORF4L1 7 ROBO4 7 TNFRSF4 7CCND3 7 FAM18B2- 7 KDM5C 7 MPDU1 7 RPL3L 7 TNS1 7 CCNL1 CDRT4 7 KIAA0664 7 MRPL53 7 RRAGA 7 TOMM40L 7 CCP110 7 FAM217B 7 KIAA1239 7 MRPS14 7 RRP15 7 TOR4A 7 CCR1 7 FAM8A1 7 KIAA1715 7 MS4A13 7 RSAD2 7 TP53111 7 CCT5 7 FAP 7 KIAA1984 7 MTMR2 7 RUSC1 7TPBGL

7 TPM1 6 AXDND1 6 EBF3 6 KCNK9 6 MTHFSD 6 SLCl5A4 7TPT1-AS1 6B3GNT9 6EEFSEC 6KCNS3 6MYLK 6SLC22A23 7 TRAF4 6 BBX 6 EFEMP2 6 KIAA1161 6 NALCN 6 SLC25A44 7 TRAPPC5 6 BCL6B 6 EFS 6 KIAA1614 6 NAV1 6 SLC25A5 7 TRIM68 6 BHLHE41 6 ELOVL3 6 KIAA1671 6 NCAPH 6 SLC25A5-AS1 7 TSPAN16 6 BMPER 6 ENTPD3 6 KIAA1755 6 NDE1 6 SLC27A5 7 TSPYL2 6 BRF2 6 EPAS1 6 KIF2A 6 NEK8 6 SLC2A6 7 TTC5 6 BTBD18 6 EPHB1 6 KLF16 6 NKG7 6 SLC30A1 7 TUB 6 BTBD8 6 EPN3 6 KLHL2 6 NME1-NME2 6 SLC30A10 7TYROBP 6 C1Oorf131 6 ERCC1 6 KPNA6 6 NME2 6 SLC30A5 7 U2AF2 6 C11orf4O 6 ERCC4 6 KRCC1 6 NME6 6 SLC45A4 7 UBR3 6 C17orf107 6 EXOC4 6 KR11 6NMS 6 SLC7A10 7UMOD 6 Ciorf105 6 EXOSC4 6 KRT15 6 NPHS2 6 SMURF2 7 UNC119B 6 C1orf210 6 FAM111B 6 LETM1 6 NPY5R 6 SNORD105 7 UPK1B 6 C20orf166 6 FAM129B 6 LGALS2 6 NUCKS1 6 SNORD105B 7 UVSSA 6 C22orf26 6 FAM134A 6 LGALS3BP 6 03FAR1 6 SOWAHD 7 VAT1 6 C5orf24 6 FAM151B 6LGMN 6 OCLN 6 SOX15 7 VAT1L 6 C5orf27 6 FAM155B 6 LIG3 6 OLFML2B 6 SOX18 7 VOPP1 6 C8orf82 6 FAM169A 6 LILRA6 6 OR10C1 6 SPATS2L 7 VWA5A 6 CABIN 6 FAM175B 6 LILRB3 6 PAQR9 6SRRM3 7 WBSCR17 6 CACNA1B 6 FAM193B 6 LIPE 6 PARP6 6 SSTR5-AS1 7 WDR96 6 CAPZB 6 FAM19A5 6 LMTK2 6 PCDHB2 6 STXBP5-AS1 7 WFDC5 6 CASS4 6 FAM219B 6LNPEP 6 PCNXL3 6 TARBP1 7 WISP3 6 CBLC 6 FAM41C 6 LOC100505933 6 PCYOX1 6 TBX1 7 ZBTB9 6 CCDC144C 6 FAM82A1 6 LOC100652739 6 PDF 6TDRD5 7 ZDHHC17 6 CCDC151 6 FAM89A 6 LOC150381 6 PDLIM5 6 THBS2 7ZDHHC3 6CCDC71 6FAM98B 6LOC256880 6PDZD4 6THSD1 7 ZFP36L1 6 CCND1 6 FARSA 6 LOC344887 6 PEAl5 6THUMPD1 7 ZNF284 6 CCR2 6FGR 6 LOC387647 6 PEX11G 6 TIAM2 7 ZNF343 6 CD180 6 FLJ30679 6 LOC400927 6 PFKFB4 6 TINAGL1 7 ZNF350 6 CD300A 6 FLJ37453 6 LOC728558 6 PIGC 6 TM4SF1 7 ZNF37BP 6 CD320 6 FOXE3 6 LOC728724 6 PIGG 6 TM4SF5 7 ZNF398 6 CD3EAP 6FUK 6LRFN4 6 PILRB 6 TMEM120B 7 ZNF490 6 CD79A 6 FUT6 6 LRIT3 6 PIM2 6 TMEM27 7 ZNF512B 6 CDC26 6 FXCl 6 LRP11 6 PKDCC 6 TMEM33 7 ZNF574 6 CDC42SE1 6 GAA 6 LRRC15 6 PKNOX2 6 TMX2-CTNND1 7 ZNF619 6 CDC5L 6 GABBR2 6 LRRC24 6 PMEPA1 6 TNFRSF10C 7 ZNF643 6 CDKALl 6 GALNTL4 6 LRRC25 6 PMF1 6 TNN12 7 ZNF71 6 CDKN2D 6 GCNT2 6 LRRC33 6 PNLIPRP2 6TOM1 7 ZNF766 6 CEP112 6GDF10 6 LTK 6 POM121 6 TP11P2 7 ZNF839 6 CHRNE 6 GGT1 6 MAB21L3 6 PPAN 6TRDMT1 7 ZRANB2 6 CIB3 6 GIMAP8 6 MAGEA8 6 PPFIA4 6 TRIM22 7 ZRANB2-AS2 6 CKAP2L 6 GNA12 6 MAGEB10 6 PPP1R3D 6 TRIM34 6AAMP 6 CLDND2 6 GNA13 6 MAL2 6 PPP5C 6 TRIM6-TRIM34 6 ACP6 6 CNIH3 6 GPR125 6 MAPK1 6 PRPF4 6 TRPA1 6 ACTN2 6COG8 6 GPT2 6 MAPK8IP2 6 PRR15 6 TTLL4 6ADAM12 6COMP 6 GRAP 6 MAPT 6 RAD9B 6 UPP1 6 ADAM22 6 COX7B 6 GTDC2 6 MAPT-AS1 6 RAMP1 6 VAX2 6 ADAM33 6 CPNE4 6 GUCY1A2 6 MARCH11 6 RARRES1 6 VPS29 6 ADCYAP1Ri 6 CPSF6 6 HADHA 6 MBNL2 6 RASD2 6 WDR12 6 ADD3 6 CR1 6 HADHB 6 MED7 6 RASEF 6 WDR72 6 AGTPBP1 6 CREB5 6 HENMT1 6 MEDAG 6 RASGRF1 6 VVHSC1Li 6 AGXT 6 CRELD1 6 HERC2P10 6 MEG8 6 RBBP6 6 WWC2 6 ALDH3B2 6 CRLF1 6 HIF1A-AS2 6 METTL21C 6 RBM18 6 YY1AP1 6 ALS2CR8 6 CRYBA2 6 HLA-DRB5 6 MFSD1 6 RFPL3 6 ZAK 6 ANGPTL6 6 CTNND2 6 HLA-F-AS1 6 MINA 6 RGS10 6 ZAP70 6 ANKRD39 6 CXCR1 6 HOXA11-AS 6 MIR1182 6 RGS5 6 ZBTB40 6 ANXA1 6 CYC1 6 HSD17B7P2 6 MIR133A2 6 RHBDD2 6 ZBTB45 6 APOL1 6 CYLD 6 HSD3B7 6 MIR195 6RHOD 6 ZC3H7A 6 APPL2 6 CYP2D6 6 HVCN1 6 MIR4285 6 RNF112 6ZCCHC8 6 ARF1 6 DAAM2 6 IL8 6 MIR497 6 RPL5 6 ZDHHC19 6 ARFIP2 6 DAP3 6 INIP 6 MIR497HG 6 RPS15A 6 ZIK1 6 ARHGAP18 6 DDX11Li0 6INPPL1 6 MIR505 6 SCGB2A2 6 ZNF135 6 ARHGAP42 6 DDX11L9 6IQGAP1 6 MIR802 6 SDC2 6 ZNF281 6 ARHGAP5 6 DLGAP3 6IRF4 6 MLLT11 6 SEPHS2 6 ZNF330 6 ARL9 6 DNAJB14 6 KCNJ1 6 MOCOS 6 SHCBP1L 6 ZNF416 6ARSG 6 DNAJB2 6 KCNJ16 6 MPP3 6 SIPAlL3 6 ZNF487P 6 ATP6V1E2 6 DYRK4 6 KCNK10 6 MRRF 6 SIRPB1 6 ZNF594

6 ZNF605 5 EGR1 5 MGAT5B 5 STAT5B 4 Cl4orfl05 4 HS6ST3 6 ZNF708 5 EIF3M 5 MIER1 5 STK16 4 C16orf55 4 HSD52 6 ZNF790 5 EIF4E3 5 MIR137HG 5 SULF1 4 C17orf59 4 HSF1 6 ZSWIM6 5 EN2 5 MIR3196 5 SUN3 4 C1QL3 4 HSPB2 6 ZUFSP 5 EOGT 5 MIR369 5 SWAP70 4 C21orf128 Cl1orf52 5 ABCF3 5 ESD 5 MIR409 5 TAF7L 4 C22orf39 4 HSPG2 5ABCG4 5 EYA4 5 MIR410 5 TAGLN 4 C2orf40 4 HTRA4 5 ACVR1C 5 FAM118A 5 MIR412 5 TECPR1 4 C2orf82 4 HUS1 5 ADAM11 5 FAM165B 5 MIR541 5 TGFB111 4 C6orf48 4 ICMT 5 ADAMTS20 5 FAM22D 5 MIR656 5 THAP11 4 C7orf55 4 ISCAl 5 ALPL 5 FAM46C 5 MRGPRF 5 THNSL2 4 C8orf56 4 ISG15 5 ANGPTL2 5 FAM49A 5 MRPL23-AS1 5 TMEM163 4 C9orfl56 4 KCNH6 5 AP2B1 5FANCA 5 MUC5B 5 TMEM184A 4 CACNA11 4 KCNJ11 5 ARF4 5 FBXL20 5 NADK 5 TMEM184B 4 CALN1 4 KCNQ5 5 ARSD 5 FUT3 5 NDUFB6 5 TMEM45A 4 CARTPT 4 KIAA1324 5 ARSJ 5 GAS2L1 5 NEK7 5 TMPRSS4 4 CCDC173 4 KIAA1586 5 ASB10 5 GLB1L 5 NEXN 5 TMX3 4 CCDC83 4 KIAA1751 5 ASGR2 5 GLT8D2 5 NKAIN4 5 TNIK 4 CD200R1 4 KIF1B 5 BATF2 5 GPN1 5 NPFFR1 5 TOP1 4 CD3G 4 KIF21B 5 BGLAP 5 GPR89B 5 NPRL3 5 TRIM31 4 CDH15 4 KL 5 BHLHE40 5 GTF2A1L 5 NRK 5 TRPC2 4 CEACAM4 4 KRT25 5 BIRC7 5 HAMP 5 OLA1 5TRRAP 4 CELF4 4 LINC00202 5 BMP7 5 HCFC1 5 OPAl 5 TSPAN4 4 CHD4 4 LINC00469 5 BTBD17 5 HCG4 5 OXLD1 5 TSPAN9 4 CLEC14A 4 LMNA 5 C12orf44 5 HIF3A 5 P2RX5 5 TYW5 4 CMTM6 4 LOC100131635 5 C15orf52 5 HINFP 5 P2RX5- 5 UBXN1 4 COL8A1 4 LOC202181 5 C19orf26 5 HMGA1 TAX1BP3 5 UNC13D 4 COR02A 4 LOC400558 5 C19orf77 5 HNF1A-AS1 5 PAK7 5 USP10 4 CWC22 4 LOC729732 5 C1QL4 5 HOMER2 5 PARP12 5 USP13 4 DBC1 4 LOH12CR2 5 C2orf47 5 HPS1 5 PBOV1 5 VDAC3 4 DEGS2 4 LRP4 5 C5orf4 5 IGDCC4 5 PCDHB10 5 WDR52 4 DEXI 4 LRRC27 5 C5orf45 5 IGF2 5 PCSK6 5 WDR78 4 DGAT1 4 LRRC40 5 C7orf55- 5 IKBKE 5 PDCD1 5 WTAP 4 DHX37 4 LRRC6 LUC7L2 5 ILl7C 5PHGDH 5 XKR6 4 DMPK 4 MAD2L2 5 C7orf57 5 IMPACT 5 PIGA 5 ZCCHC14 4 DNAH11 4 MAPK6 5 C9orfl23 5 IQCAl 5 PIN1P1 5 ZFC3H1 4 DNAJC13 4 MAPT-IT1 5 C9orf3 5 KCNC4 5 PKIG 5 ZNF554 4 DOC2GP 4 MDH2 5 CACNB3 5 KCNN4 5 PLEKHD1 5 ZNF645 4 DPCR1 4 MIR141 5 CACNB4 5 KIAA1210 5 POLRMT 5 ZNF714 4 EGR2 4 MIR200C 5CACNG4 5 KIAA1244 5 PPP1R3G 4 ABCAl 4 ELFN2 4 MIR21 5 CCDC102B 5 KIF25 5PRDM2 4 ABO 4 EMID2 4 MIR4284 5 CCDC121 5 KLHL26 5 PSRC1 4 ADCY5 4 FAM131C 4 MIR4316 5 CCDC137 5 LCP1 5 RALGPS1 4 ADORA2A 4 FAM204A 4 MIR519D 5 CDH24 5 LDB3 5 RAN 4AMFR 4 FAM228A 4 MIR548G 5 CDKN2C 5 LIMAl 5 RAPGEF1 4 ANKH 4 FAM35B 4 MKLN1 5 CDX2 5 LINC00313 5 RHOJ 4 ANKRD22 4 FAM60A 4 MPP2 5 CENPT 5 LITAF 5 RNU6-66 4 ANO10 4 FANK1 4 MREG 5CHRD 5 LOC100129924 5 RPS19BP1 4 ANTXR1 4 FBXL4 4 MTNR1A 5CHRM5 5 LOC100652768 5 SCNN1G 4 AP2S1 4 FGF1 4 MYO5A 5CHUK 5 LOC151171 5 SELPLG 4 ARHGAP29 4 FGF9 4 NDUFAF5 5 CLASRP 5 LOC221122 5 SEMA3E 4 ARHGEF16 4 FLOT2 4 NEURL4 5 CMPK1 5 LOC554223 5 SFMBT2 4 ARHGEF3 4FOXC2 4 NME7 5 CNKSR3 5 LOC649395 5 SFRP2 4 ASB13 4 FUT2 4 NPPA-AS1 5COMMD3 5 LOC730101 5SGCZ 4 ASIC2 4 GFRA3 4 NPTXR 5 COMMD3-BMI1 5 LOH12CR1 5 SH3GL1 4 ATN1 4 GIMAP5 4 NWD1 5 CSRP2 5LONRF1 5 SIGLEC5 4 ATP1A4 4 GP1BB 4 NXF3 5 CWF19L1 5 LPGAT1 5 SIRT6 4 ATP7A 4 GPC1 4 P2RX1 5 CYP1B1 5LRRN4 5 SKAP2 4 AURKB 4 GPR162 4 PALLD 5 DCLK1 5 LSP1P3 5 SLC1OA7 4 BAALC 4 GPS2 4 PARP10 5DDO 5 LUC7L 5 SLC12A7 4 BA1l 4 GRB14 4 PCBP1 5DGKG 5 LUC7L2 5 SLC1A4 4 BARHL2 4 GRINA 4 PCBP1-AS1 5 DLGAP1-AS3 5 LY75 5 SLC26A7 4BCAM 4 GUSBP2 4 PCDH11X 5 DNAH8 5 LY75-CD302 5 SLCO1Cl 4 BEGAIN 4 HERC1 4 PCDH15 5 DRAXIN 5 MAP1LC3A 5 SLFN13 4 BLZF1 4 HES6 4 PCGF6 5 DSCAM 5 MEF2D 5 SOX7 4 BRD9 4 HIP1R 4 PCSK9 5 DSCR9 5 MEIS3 5 SPICE 4 ClOorf9l 4 HNF1B 4 PEAR1 5 DUSP28 5 MERTK 5 SRPK2 4 C11orf52 4 HOXB-AS5 4PGAM2 5 E2F2 5 MGAT3 5 SSX1 4 C12orf6O 4 HS1BP3 4 PHOSPHO2

4 PHOSPHO2- 4 TPD52 3 DGKH 3 MIR3684 3SYNGR1 2 ACOXL KLHL23 4 TRIM40 3 DIEXF 3 MIR378D2 3 SYNJ2BP 2 ACPP 4 PLA2G4A 4 TRIM59 3 DMTF1 3 MIR517A 3TACC2 2 ACPT 4 PLEKHN1 4 TRIP13 3 DOCK1 3 MIR518C 3 TAS1R3 2 ACRBP 4 PLXNA4 4 TRMT13 3 DPY19L2P3 3 MIR524 3 TBC1D7 2 ACSL1 4 PLXNB2 4 TSPAN1 3 DSG3 3 MIR550A3 3 TET2 2 ACTL8 4 PMVK 4 TSPAN2 3 DZANK1 3 MMP21 3 TGIF1 2 ACTRT3 4 PP14571 4 UBE4B 3 ECSIT 3 MPPED2 3THADA 2 ACVR2B 4 PPP1R14A 4 UPK3B 3 EGLN2 3 MRPL15 3 THBS3 2 ACVR2B-AS1 4 PPP4R1L 4 UTF1 3 EIF4A2 3 MRPL39 3 TIGD3 2 ACVRL1 4 PRNT 4 VANGL2 3 EIF4H 3 MS4A15 3 TMEM120A 2 ACYP1 4 PRSS21 4 VMP1 3 FAM101B 3 MTMR6 3 TMEM132D 2 ADAM10 4 PRSS33 4 WBP11 3 FAM124A 3 MTX1 3 TMEM154 2 ADAM15 4 PTAR1 4 ZFR 3 FAM162B 3 MUL1 3 TMIE 2 ADAMTS18 4 PTGES 4 ZIC5 3 FFAR2 3 MYBPC3 3 TNFAIP8L2 2 ADAMTS5 4RAB22A 4ZKSCAN4 3 FOLR3 3 MYCBPAP 3 TRAK1 2ADAMTSL1 4 RAB3A 4 ZNF202 3 FRMD6-AS2 3 MYF5 3 TRPV1 2 ADAMTSL5 4 RAB9B 4 ZNF280C 3 FUOM 3 MYO10 3 TUBA4A 2 ADCY4 4 RABEP1 4 ZNF57 3 GIPC3 3 NAA60 3 TUBA4B 2 ADD2 4 RASGRP2 4 ZNF687 3 GMDS 3NAMPT 3 UBE2D1 2 ADNP 4 RNF150 4 ZNRF1 3 GRIA3 3 NBPF9 3 UGT8 2 ADORA2B 4 RNFT2 4 ZYG11A 3 GRIA4 3 NDFIP1 3 USP3 2 ADRA1B 4 RPN1 3 ABAT 3 HAS2 3 NHLH2 3 UTP14A 2 ADRA1D 4 RTKN 3 ACAD9 3 HAS2-AS1 3 NKAP 3 UTY 2 AEBP2 4 RTP2 3ADAM5 3 HEPHL1 3 NOP10 3 VENTX 2 AEN 4 RUNX1T1 3 ADAMTS12 3 HIST1H2AE 3 NT5DC1 3 VPS39 2 AFAP1Ll 4 SASS6 3 ADAMTS7 3 HLA-DMA 3 OR10G9 3 WIF1 2 AMID 4 SATB2 3 ADAMTS9 3 HLA-DRB6 3 OR2L13 3 WT1 2 AGGF1 4 SATB2-AS1 3 ADRA2C 3 HSF5 3 OSBPL9 3 WWC3 2 AGK 4 SCAND3 3 AHCYL2 3 HUNK 3 OXTR 3 XAF1 2 AGL 4 SCRN1 3 AHSP 3 HYLS1 3 PAD14 3 XCR1 2 AGT 4 SDS 3 AKAP13 3 IGF1 3 PDCD1LG2 3 ZNF143 2 AGTR2 4 SDSL 3 ALPPL2 3 ITGAE 3 PDP1 3 ZNF274 2 AGXT2L1 4SEPT5 3ANXA11 3ITPKA 3PDZRN4 3ZNF329 2AHCTF1 4 SEPT5-GP1BB 3 APOF 3 JPH1 3 PHF19 3 ZNF629 2 AIFM2 4 SERPINA10 3 ASGR1 3 KANK3 3 PHLDB2 3 ZNF682 2 AIFM3 4 SERPINF2 3 ATP1A1OS 3 KDM3A 3 PHOSPHOl 3 ZNF879 2 AIG1 4 SFT2D3 3 ATP2C1 3 KIAA1551 3 PNP 2A1BG 2 AIM1 4 SFTA2 3 ATP6VOCP3 3 KLHDC1 3 POLE2 2 A1BG-AS1 2 AK4 4 SLC25A10 3 ATPBD4 3 KLHL20 3 POLE4 2 A2M-AS1 2 AKAP9 4 SLC2A9 3 ATPBD4-AS1 3 KLHL29 3 POU2F1 2 AATF 2 AKIP1 4 SNORD48 3 AVEN 3 KRT23 3 PPAP2A 2 ABCAl7P 2 AKIRIN2 4 SNORD52 3 AVL9 3 KRT77 3 PPIL6 2 ABCA3 2 AKR1B1 4SOBP 3BCAR3 3 LANCL3 3PSMB5 2ABCA4 2AKR7L 4 SORCS1 3 BIN3 3LDLRAD2 3PSMD5 2 ABCA8 2 AKT2 4 SP1 3 BMPR2 3 LEKR1 3PSMD6 2 ABCB1 2 ALDH1Li-AS2 4 SRSF11 3 BPGM 3 LOC100499194 3 PTGFR 2 ABCB4 2 ALDH1L2 4ST5 3BPHL 3LOC100499489 3PTPRC 2ABCB7 2ALDH2 4 STX1A 3 C15orf55 3 LOC100505687 3 PTPRS 2 ABCB9 2 ALG14 4 STYXL1 3 C20orfl12 3 LOC100507547 3 RAB20 2 ABCC4 2 ALS2 4 SUCLG2 3 C2orf54 3 LOC253039 3 RAB39B 2 ABCD1 2 ALX4 4 SULT2B1 3 C8orf74 3 LOC283050 3 RAB4B-EGLN2 2 ABHD1 2 AMDHD1 4 SUMF1 3 CACNA2D3 3 LOC283177 3 RABL5 2 ABHD11 2 AMICA1 4 SYN3 3 CCDC57 3 LOC344967 3 RFX7 2 ABHD15 2 AMMECR1 4 SYNCRIP 3 CCDC90B 3 LOC440900 3 RIMS1 2 ABHD3 2AMN1 4 SYNJ2BP- 3CCNY 3 LOC91948 3 RPL22L1 2 AB13 2 AMOTL1 COX16 3 CD177 3 LRP4-AS1 3 RTN4RL2 2 ABLIM3 2 ANGPT4 4 TBCA 3 CDR2 3 LZTS1 3 SAC3D1 2 ABP1 2 ANKIB1 4TCEA3 3 CLDN19 3 MAP3K1 3SEC31B 2ACADS 2ANKK1 4 TCEAL2 3 CLDN2 3 MARCH2 3 SGMS1 2 ACADSB 2 ANKRD13D 4 TEKT4 3 CLEC5A 3 MATR3 3 SIGLEC14 2 ACAP1 2 ANKRD30BP2 4 TEX11 3 CLIC2 3 MEIOB 3 SLC25A42 2 ACBD4 2 ANKRD34A 4 THEMIS2 3 CPT1C 3 METAP1 3 SMPD2 2 ACBD5 2 ANKRD53 4 TMEM106C 3 CSMD3 3 MICA 3 SNORA81 2 ACOT7 2 ANKRD63 4 TMEM145 3 CYP21A1P 3 MIR100HG 3 SOX5 2 ACOT8 2 ANKS1B 4 TMEM66 3 CYP21A2 3 MIR1248 3 STAMBP 2 ACOT9 2 ANKS3 4 TNFRSF19 3 DAB21P 3 MIR125B1 3 STAT2 2 ACOX2 2ANO4 4TNR 3 DDX46 3 MIR200B 3 SULT6B1 2 ACOX3 2 ANP32B

2 ANXA2R 2 ATPIF1 2 C12orf29 2 C8orf44 2 CCIN 2 CHST5 2 AOAH 2 ATXN7 2 C12orf56 2 C8orf58 2 CCL24 2 CHTF18 2 AOX2P 2 AUH 2 C12orf65 2 C8orf73 2 CCL3 2 CIRBP 2 AP1S3 2 AURKAIP1 2 C14orf180 2 C8orf86 2 CCNB1IP1 2 CIRBP-AS1 2 AP3M2 2 AVIL 2 C14orf182 2 C9orfl16 2 CCND2 2 CKB 2 AP4B1-AS1 2 AVP11 2 C14orf23 2 C9orf117 2CCNG2 2 CKS1B 2 AP4E1 2 AXIN2 2 C14orf64 2 C9orf169 2 CCNH 2 CLCC1 2 APBB11P 2 AZIN1 2 C15orf27 2 C9orfl74 2 CCR7 2 CLCN4 2 APBB3 2 B3GALNT1 2 C15orf37 2 C9orf4l 2 CCT2 2 CLCN7 2 APLP2 2 B3GNT3 2 C15orf4l 2 C9orf50 2 CCT7 2 CLCNKB 2 APOBEC3A 2 B3GNT5 2 C16orf5 2 CAll 2 CD19 2 CLDN23 2 APOBEC3C 2 B3GNT8 2 C16orf70 2 CA5A 2 CD1D 2 CLDN5 2 APOL4 2 B4GALNT4 2 Cl7orfl03 2 CA7 2 CD244 2 CLDN8 2 APOLD1 2 B4GALT3 2 C17orf49 2 CABLES2 2 CD248 2 CLDND1 2APOOL 2 BACH2 2 C17orf53 2 CACNA1D 2 CD34 2 CLEC3B 2 AQP11 2 BAHCC1 2 C17orf62 2 CACNA1S 2 CD37 2 CLIP1 2 AQP5 2 BAHD1 2 C17orf74 2 CACTIN-AS1 2 CD48 2 CLMN 2 AQP9 2 BAIAP2L1 2 C17orf96 2 CACULl 2 CD59 2 CLMP 2 AQPEP 2 BANP 2 C18orf32 2 CADM1 2 CD68 2 CLN5 2 ARHGAP10 2 BATF 2 C18orf34 2 CADPS2 2 CD72 2 CLNK 2 ARHGAP12 2 BCAP31 2 C19orf24 2 CALHM2 2 CD82 2 CLPTM1 2 ARHGAP15 2 BCDIN3D-AS1 2 C19orf45 2 CALM 2 CD8A 2 CLPTM1L 2 ARHGAP30 2 BCL2 2 C19orf57 2 CAMKK2 2 CDA 2 CLSTN2 2 ARHGAP35 2 BCL2L1 2 C19orf60 2 CAMP 2 CDAN1 2 CLTCL1 2 ARHGAP39 2 BCL2L11 2 C1QL1 2 CAMSAP1 2 CDC42BPA 2 CLVS2 2 ARHGAP6 2 BCL2L14 2 C1QTNF6 2 CAP2 2 CDC42BPG 2 CMC2 2 ARHGDIA 2 BCL7A 2 C1S 2 CAPN1 2 CDC42EP5 2 CMTM4 2 ARHGDIB 2 BCL9L 2 C1orf123 2 CAPN2 2 CDCA2 2 CNEP1R1 2 ARHGEF12 2 BDH1 2 C1orf151-NBL1 2 CARNS1 2 CDH13 2 CNGA1 2 ARHGEF15 2 BECN1 2 C1orf172 2 CARS2 2 CDH20 2 CNGB1 2 ARHGEF37 2 BEND5 2 C1orf174 2 CASP3 2 CDH22 2 CNIH 2 ARHGEF7 2 BEND7 2 C1orf2l 2 CASP8 2CDHR3 2 CNTD1 2 ARID1A 2 BEST1 2 C1orf229 2 CASQ1 2 CDK5R1 2 CNTD2 2 ARL10 2 BET3L 2 C1orf50 2 CATSPER2P1 2 CDK6 2 CNTN1 2 ARL13B 2 BEX4 2 C1orf86 2 CBFA2T2 2 CDK9 2 CNTN4 2 ARL15 2 BEX5 2 C20orf151 2 CBLL1 2 CDKL2 2 CNTNAP3 2 ARL2BP 2 BHLHA15 2 C20orf201 2 CBLN2 2 CDKN1A 2 COA3 2ARMC9 2 BICC1 2 C20orf94 2 CBX1 2 CDKN1C 2 COA5 2 ARMCX1 2 BIK 2 C20orf96 2 CBY1 2 CDO1 2 COBL 2 ARR3 2 BLVRA 2 C21orf33 2 CC2D1B 2 CDPF1 2 COCH 2 ARRB1 2 BMF 2 C21orf49 2 CCAR1 2 CEACAM1 2 COL12A1 2 ARRDC5 2 BMI1 2 C21orf56 2 CCBL2 2 CEACAM6 2 COL13A1 2 ARSB 2 BMP1 2 C21orf7 2 CCDC101 2 CEBPE 2 COL15A1 2 ARSI 2 BMP4 2 C22orf28 2 CCDC102A 2 CEBPG 2 COL19A1 2 ASAP1 2 BMPR1B 2 C2CD2L 2 CCDC104 2 CECR2 2 COL21A1 2 ASB1 2 BMX 2 C2orfl6 2 CCDC105 2 CELF5 2 COL25A1 2 ASB18 2 BNC1 2 C2orf42 2 CCDC106 2 CENPM 2 COL3A1 2 ASB6 2 BNC2 2 C2orf43 2 CCDC111 2 CENPN 2 COLQ 2 ASCL4 2 BOK 2 C2orf50 2 CCDC124 2 CEP164 2 COQ5 2 ASCL5 2 BOK-AS1 2 C2orf68 2 CCDC144A 2 CEP55 2 CORO1A 2 ASPA 2 BOP1 2 C2orf8l 2CCDC15 2 CEP76 2 COTL1 2 ASS1 2 BR13BP 2 C3 2 CCDC150 2 CEP78 2 COX10 2 ASXL2 2 BTAF1 2 C3orf27 2 CCDC152 2 CERS2 2 COX10-AS1 2 ATAD3B 2 BTBD16 2 C3orf36 2 CCDC166 2 CES3 2 COX15 2 ATAD3C 2 BTBD6 2 C3orf78 2 CCDC167 2 CFH 2 COX16 2 ATAD5 2 BTF3 2 C4orf21 2CCDC19 2 CFLAR 2 COX17 2 ATF5 2 BTG4 2 C4orf27 2 CCDC24 2 CFP 2 COX19 2 ATF7 2 BTRC 2 C5orf52 2 CCDC37 2 CGB2 2 COX6A2 2 ATG16L1 2 BUB3 2 C5orf56 2 CCDC40 2 CGREF1 2 CPA2 2 ATP10D 2 BYSL 2 C6orfl 2 CCDC42 2 CHADL 2 CPEB4 2 ATP13A1 2 C1orf128 2 C6orfl64 2 CCDC42B 2 CHAMP1 2 CPLX3 2 ATP1B1 2 C10orf82 2 C6orfl70 2 CCDC6 2 CHCHD4 2 CPNE2 2 ATP5L2 2 C11orf45 2 C7orfl3 2 CCDC67 2 CHIC1 2 CPNE9 2 ATP5S 2 C11orf53 2 C7orf26 2 CCDC77 2 CHML 2 CPQ 2 ATP6AP2 2 C11orf68 2 C7orf4l 2 CCDC78 2 CHMP2A 2 CPSF3 2 ATP6V1F 2 C11orf75 2 C7orf65 2CCDC9 2 CHMP3 2 CPSF4L 2 ATP8B3 2 C11orf88 2 C7orf69 2 CCDC90A 2 CHRNA4 2 CPT2 2 ATP8B4 2 Cl2orfl0 2 C8orf3l 2 CCDC92 2 CHRNB1 2 CPVL

2 CPXCR1 2 DGKA 2 DYNLL1 2 ESM1 2 FAM83D 2 FSCN2 2CPXM2 2DGKI 2DYNLRB2 2ESR1 2FAM83F 2FTO 2 CPZ 2 DGKQ 2 DYRK1B 2 ESR2 2 FAM98C 2 FTX 2CRABP1 2DHCR24 2DYRK2 2ESYT1 2FASTKD3 2FXN 2 CRB2 2 DHDH 2 E2F4 2 ESYT3 2 FASTKD5 2FXYD6 2 CREB3L2 2 DHRS11 2 EARS2 2 ETNK1 2 FBF1 2 FYB 2CREBBP 2DHRS3 2EB13 2ETS1 2FBL 2FYN 2 CREG2 2 DHRS7C 2 ECH1 2 ETV1 2 FBLN2 2 GABARAPL1 2 CRHR1 2 DHX29 2 ECHDC3 2 EXOC6 2 FBN1 2 GABRG3 2 CRISP2 2 DHX35 2 ECT2L 2 EXOSC10 2 FBXL14 2 GABRR1 2 CRISPLD1 2 DHX40 2 EDF1 2 EXT1 2 FBXO10 2 GABRR3 2 CRK 2 DHX57 2 EDIL3 2 EXTL3 2 FBXO25 2 GADL1 2 CRTAM 2 DIABLO 2 EDN2 2 EYS 2 FBXO27 2 GAGE13 2 CRYGD 2 DID01 2 EDN3 2 F11R 2 FBX034 2 GAL 2 CRYGN 2 DIRAS2 2EDNRA 2 F3 2 FBXO4 2 GALC 2 CRYZL1 2 DISP1 2 EEF1A2 2 F8 2 FBXW4 2 GALM 2 CSF3R 2 DIXDC1 2 EFCAB4A 2 FAAH 2 FBXW5 2 GALNT13 2 CSGALNACT2 2 DLG3 2 EFCAB4B 2 FABP6 2 FBXW9 2 GALNT7 2CSK 2DLGAP4 2EFHB 2FAF2 2FCER1G 2GALNT8 2 CSN1S2BP 2 DLL4 2 EFHD2 2 FAIM2 2FCHSD1 2 GALR2 2 CSNK1A1 2 DNAH5 2 EFNA4 2 FAM101A 2 FCN3 2 GAP43 2 CSNK1D 2 DNAH7 2 EFNB1 2 FAM108C1 2 FER 2 GAPDHS 2 CSNK1G1 2 DNAH9 2 EFR3A 2 FAM110A 2 FER1L4 2 GAS2L2 2 CSNK2A1 2 DNA12 2 EHD1 2 FAM115A 2 FGD1 2 GATA5 2 CSRNP1 2 DNAJB1 2 EHD3 2 FAM120B 2 FGF11 2 GCAT 2 CSRP3 2 DNAJB12 2 EHF 2 FAM123A 2 FGF22 2 GCFC1 2 CT47B1 2 DNAJB13 2 EIF2AK1 2 FAM123B 2 FGF23 2 GCSAM 2 CTBP1 2 DNAJC11 2 EIF2C2 2 FAM127C 2 FGFBP2 2 GDA 2 CTBP1-AS1 2 DNAJC18 2 EIF2S2 2 FAM131A 2 FGFR3 2 GD12 2 CTGF 2 DNAJC2 2 EIF4EBP1 2 FAM131B 2 FHDC1 2 GEMIN2 2 CTIF 2 DNAJC8 2 EIF4G3 2 FAM133B 2 FHL2 2 GEMIN4 2 CTSF 2 DNER 2 EIF5A2 2 FAM133DP 2 FHL3 2 GEMIN6 2 CTSG 2 DNTTIP1 2 ELAC1 2 FAM150B 2 FIGNL2 2 GEMIN7 2 CTTNBP2NL 2 DNTTIP2 2 ELF3 2 FAM157A 2 FITM2 2 GFER 2 CUL5 2 DOCK10 2 ELFN1 2 FAM159A 2 FKBP1A 2 GFPT2 2 CUTC 2 DPF1 2 ELL3 2 FAM160B2 2 FKBP1A- 2 GFRAl 2 CWC25 2 DPF2 2 ELN 2 FAM163A SDCBP2 2 GFRA2 2 CXADR 2 DPH5 2 ELSPBP1 2 FAM171A1 2 FKBP9 2 GGA1 2 CXCL1 2 DPM2 2 EMBP1 2 FAM173A 2 FLAD1 2 GGTLC2 2 CXCR4 2 DPP10 2 EMC7 2 FAM174B 2 FLJ12825 2 GHRL 2 CXorf65 2 DPPA3 2 EML2 2 FAM176B 2 FLJ14107 2 GHRLOS 2 CYB561D2 2 DPYSL2 2 EMP3 2 FAM176C 2 FLJ16171 2 GINS3 2 CYBASC3 2 DPYSL3 2ENDOG 2 FAM178B 2 FLJ35390 2 GIPC2 2 CYFIP2 2 DPYSL5 2 ENHO 2 FAM185A 2 FLJ41941 2 GJB2 2 CYP11A1 2 DRAP1 2 ENPP6 2 FAM188B 2 FLJ42351 2 GJC2 2 CYP19A1 2 DRD2 2 ENPP7 2 FAM18B1 2 FLJ43663 2 GK5 2 CYP20A1 2 DRD4 2 ENSA 2 FAM190B 2 FLNC 2 GLB1 2 CYP27C1 2 DSC2 2 ENTHD1 2 FAM192A 2 FLOT1 2 GLB1L3 2 CYP2J2 2 DSCAML1 2 ENTPD2 2 FAM194A 2 FLT1 2 GLCC11 2 CYP2S1 2 DSCR3 2 ENTPD4 2 FAM198B 2 FLT4 2 GLI1 2 CYP2W1 2 DSCR6 2 EPB41 2 FAM207A 2 FLVCR2 2 GLIS3 2 CYP4F24P 2 DSEL 2 EPB41L1 2 FAM227A 2 FLYWCH1 2 GLO1 2DAPK2 2DSP 2EPB49 2FAM24B 2FMNL2 2GLRX 2 DARC 2 DTNB 2 EPC1 2 FAM24B- 2 FNDC3B 2 GLRX5 2 DAZAP1 2 DTNBP1 2 EPC2 CUZD1 2FNDC5 2GLS2 2 DBIL5P 2 DTX4 2 EPG5 2 FAM26D 2 FNIP1 2 GLT1D1 2 DBNL 2 DUOX2 2 EPHA2 2 FAM26E 2 FNIP2 2 GLTSCR2 2 DBP 2 DUOXAl 2 EPHA3 2 FAM27L 2FOXD2 2 GLUD2 2 DCAF12 2 DUOXA2 2 EPS8L2 2 FAM32A 2 FOXD4L1 2 GLYR1 2 DCAF8L2 2 DUS1L 2 EPST11 2 FAM40A 2FOXN2 2 GMIP 2DCBLD1 2DUS3L 2EPT1 2FAM47E 2FOXO3 2GMPS 2DCHS2 2DUSP22 2ERAS 2FAM53B 2FOXO4 2GNA12 2DCK 2DUSP26 2ERBB2 2FAM5B 2FOXP2 2GNAL 2DCLRE1A 2DUSP5 2ERC2 2FAM69B 2FOXP4 2GNB1 2DCUN1D1 2DYDC1 2ERCC6L2 2FAM72A 2FRG2 2GNE 2 DDIT3 2 DYDC2 2 ERF 2 FAM73A 2 FRG2B 2 GNG11 2DDX47 2DYNC1H1 2ERN2 2FAM78A 2FRMD6 2GNG5 2 DGCR8 2 DYNC111 2 ERP44 2 FAM78B 2 FRRS1L 2 GNGT2

2 GNMT 2 HEXDC 2 ILl3RA2 2 KCNUl 2 LAPTM5 2 LOC100129858 2 GOLGA8B 2 HEXIM1 2 ILl7D 2 KCP 2 LARP1 2 LOC100130015 2 GON4L 2 HEYL 2 ILl7RD 2 KCTD1 2 LARP1B 2 LOC100130238 2 GOT2 2 HHIPL2 2 IL1R2 2 KCTD11 2 LARP4B 2 LOC100130417 2 GPATCH3 2 HIST1H2AJ 2 ILlRAP 2 KCTD15 2 LAT2 2 LOC100130557 2 GPC4 2 HIST1H2APS1 2 IL20RB 2 KCTD16 2 LCE3A 2 LOC100131289 2 GPC6 2 HIST1H2BO 2 IL23A 2 KCTD6 2 LCLAT1 2 LOC100131655 2 GPD2 2 HIST1H31 2 IL28A 2 KCTD9 2 LCN12 2 LOC100131691 2 GPKOW 2 HIST1H3J 2 IL2RG 2 KDELC2 2 LCN8 2 LOC100131825 2 GPN2 2 HIST1H4L 2 ILDR1 2 KDELR2 2 LDHAL6A 2 LOC100133669 2 GPR1 2 HIST4H4 2 INE2 2 KDM1A 2LDLRAD3 2 LOC100134317 2 GPR111 2 HIVEP3 2INHBA 2 KDM3B 2 LDLRAP1 2 LOC100134368 2 GPR113 2 HK1 2 INHBA-AS1 2 KDM5A 2 LDOC1L 2 LOC100188947 2 GPR135 2 HLA-DRB1 2INHBE 2 KDM5B 2 LEFTY2 2 LOC100287482 2 GPR142 2 HLF 2 INMT-FAM188B 2 KDM5B-AS1 2LENG9 2 LOC100288255 2 GPR144 2 HMBOX1 2 IN080 2 KEL 2 LEP 2 LOC100288911 2 GPR153 2 HMGB3P1 2INPP1 2 KIAA0226L 2 LEPR 2 LOC100289511 2 GPR156 2 HN1 2INS 2 KIAA0232 2 LEPRE1 2 LOC100499227 2 GPR35 2 HNRNPCL1 2INTS2 2 KIAA0247 2 LEPRELl 2 LOC100499484 2 GPR37 2 HNRNPF 2INTS9 2 KIAA0754 2LEPROT 2 2 GPR6 2 HNRNPH1 21QCD 2 KIAA0930 2 LETMD1 LOC100499484 2 GPR84 2 HOOK3 2IQCH 2 KIAA0947 2 LGALS12 C90RF174 2 GPRIN2 2 HORMAD2 2 IQCJ-SCHIP1 2 KIAA1191 2 LGALS4 2 LOC100505495 2 GPSM3 2 HOTAIR 2IQUB 2 KIAA1199 2 LGALS7B 2 LOC100505583 2 GPX7 2 HOTAIRM1 2ISYNAl 2 KIAA1217 2 LGALS9B 2 LOC100505666 2 GRAMD1B 2 HOXAl 2ITFG1 2 KIAA1467 2 LHFPL3-AS2 2 LOC100505875 2 GRID2 2 HOXB7 2 ITGA1 2 KIAA1683 2 LHFPL4 2 LOC100506082 2 GRIK1 2 HOXC11 2 ITGA11 2 KIAA1731 2 LHFPL5 2 LOC100506274 2GRM1 2 HOXC9 2 ITGA2 2 KIF26A 2LHPP 2 LOC100506585 2GRM2 2 HPS4 2 ITGA5 2 KIF3A 2 LHX3 2 LOC100506668 2GRM3 2HR 2 ITGA8 2 KIFC3 2 LHX6 2 LOC100507066 2GRM6 2 HS3ST6 2 ITGB1 2 KLB 2 LIMK2 2 LOC100507299 2GRM7 2 HSD11B1L 2 ITGB1BP1 2 KLF14 2 LIN7B 2 LOC100507373 2GRN 2 HSD17B1 2 ITGB3 2 KLF2 2 LINCO0028 2 LOC100507443 2GSG1L 2 HSF4 2 ITGB7 2 KLHDC8A 2 LINCO0167 2 LOC100507564 2 GSN 2 HSPA1B 2ITK 2 KLHL22 2 LINC00242 2 LOC100507605 2 GSTM4 2 HSPA4L 2ITM2C 2 KLHL31 2 LINC00264 2 LOC100507634 2 GTF2A1 2 HSPA9 2ITPA 2 KLK10 2 LINCO0265 2 LOC100508120 2 GTF21RD1 2 HSPB6 2 ITPK1-AS1 2 KLK11 2 LINC00299 2 LOC101055625 2 GTF21RD1P1 2 HTR1B 2ITPR1 2 KLK12 2 LINCO0307 2 LOC147670 2 GUSBP4 2 HTR4 2 ITPRIP 2 KLK6 2 LINCO0310 2 LOC148709 2 GXYLT2 2 HTR6 2IVNS1ABP 2 KPNA1 2 LINCO0319 2 LOC150197 2 HiFO 2 HYAL2 2 IZUMO4 2 KRBA2 2 LINC00426 2 LOC154449 2 H2AFJ 2IBSP 2 JAKMIP2 2 KREMEN1 2 LINC00466 2 LOC154822 2 H2AFY 21DH2 2 JAKMIP2-AS1 2 KRIT1 2 LINCO0471 2 LOC155060 2 H2BFM 2IDUA 2JMJD1C 2 KRT1 2 LINCO0475 2 LOC200772 2 H3F3A 2IER3 2JOSD1 2 KRT2 2 LINC00476 2 LOC202781 2 H3F3AP4 2 IFF01 2JPH2 2 KRT3 2 LINC00478 2 LOC255130 2 HADH 2 IF116 2JPX 2 KRT7 2 LINCO0574 2 LOC256021 2 HAGHL 2 IF127 2JUNB 2 KRT80 2 LINCO0602 2 LOC283194 2 HARS 2 IF130 2JUP 2 KRT86 2 LINCO0612 2 LOC284798 2 HARS2 2 IF144L 2 KARS 2 KRT8P41 2 LINC00634 2 LOC284865 2 HAVCR1 2 IF16 2 KAT2B 2 KRTAP16-1 2 LINC00638 2 LOC284889 2HBQ1 2 IFITM10 2 KATNB1 2 KRTAP20-1 2 LINCO0675 2 LOC284950 2 HCAR1 2 IFITM3 2 KATNBL1 2 KRTAP20-4 2 LLGL1 2 LOC285626 2HCG9 2 IFITM4P 2 KAZN 2 KRTAP5-6 2LMAN2 2 LOC285696 2 HCLS1 2 IFNAR2 2 KBTBD11 2 KRTAP6-1 2 LMF1 2 LOC285972 2 HCN2 2IFRD1 2 KCNA5 2 KRTCAP3 2LMO7 2 LOC286059 2 HCRTR1 21FT88 2KCNB1 2KSR1 2 LOC100127888 2 LOC338963 2 HDAC11 2IGF2BP2 2 KCNE4 2 KSR2 2 LOC100128071 2 LOC349160 2 HDAC2 2IGFBP1 2 KCNG3 2 KYNU 2 LOC100128076 2 LOC399815 2 HDAC9 2IGLL1 2 KCNG4 2 LTD1 2 LOC100128098 2 LOC400680 2 HDDC2 2IGLON5 2 KCNH1 2 L2HGDH 2 LOC100128338 2 LOC400940 2 HDDC3 2IGSF3 2 KCNJ15 2 LAGE3 2 LOC100128568 2 LOC401164 2 HECTD2 2IKZF1 2 KCNJ5 2 LAMA5 2 LOC100129046 2 LOC401320 2HEG1 2IKZF2 2 KCNJ8 2 LAMB2 2 LOC100129250 2 LOC402160 2 HELQ 2IKZF5 2 KCNQ4 2LAMTOR4 2 LOC100129345 2 LOC440461 2 HEPACAM 2 IL12B 2 KCNT2 2LAMTOR5 2 LOC100129636 2 LOC440563

2 LOC440600 2 MACC1 2 MGC39372 2 MLF1 2 MZF1 2 NMRAL1 2 LOC440944 2 MACROD1 2 MGC57346 2 MLIP 2 MZT2B 2 NNMT 2 LOC441242 2 MAFF 2 MICAL2 2 MLKL 2 NAA10 2 NOL7 2 LOC442459 2 MAGEC1 2 MIER2 2 MLLT4 2 NAA16 2 NOLC1 2 LOC541473 2 MAGEC3 2 MIIP 2 MLLT4-AS1 2 NAALAD2 2 NOM1 2 LOC574538 2 MAGEE1 2 MIR1184-1 2 MLLT6 2 NACC2 2 NOP14-AS1 2 LOC606724 2 MAGOH 2 MIR1184-2 2 MLNR 2 NADKD1 2 NOTCH 2 LOC641746 2 MAK16 2 MIR1184-3 2 MMEL1 2 NAGA 2 NOVAl 2 LOC643037 2 MAL 2 MIR1245A 2 MMP11 2 NANP 2 NOXO1 2 LOC643529 2 MAMDC4 2 MIR1275 2 MMP17 2 NAP1L4 2 NPBWR2 2 LOC643542 2 MAN2B1 2 MIR1306 2 MNS1 2 NAP1L6 2 NPDC1 2 LOC644189 2 MAP1B 2 MIR135A1 2 MOBP 2 NAPB 2 NPEPL1 2 LOC644554 2 MAP2K4P1 2 MIR142 2 MOCS1 2 NAPSB 2 NPRL2 2 LOC644990 2 MAP3K13 2 MIR153-2 2 MOGAT3 2 NARFL 2 NPTX2 2 LOC648809 2 MAP3K3 2 MIR181A2HG 2 MONlA 2 NARG2 2 NR1D2 2 LOC649330 2 MAP3K8 2 MIR205 2 MORN2 2 NAT9 2 NR1H3 2 LOC728012 2 MAP3K9 2 MIR205HG 2 MORN4 2 NAV3 2 NR2E1 2 LOC728175 2 MAP4K1 2 MIR2861 2 MOS 2 NBL1 2 NR2F1 2 LOC728392 2 MAP4K2 2 MIR3187 2 MOXD1 2 NBPF3 2 NR5A1 2 LOC728431 2 MAP4K4 2 MIR32OB1 2 MPC1 2 NCAM2 2 NR6A1 2 LOC728730 2 MAP6D1 2 MIR320C1 2 MPL 2 NCF4 2 NRARP 2 LOC729609 2 MAPK13 2 MIR339 2 MRAP2 2 NCKAP5L 2 NRBP2 2 LOC729966 2 MAPK14 2 MIR34B 2 MRFAP1 2 NCL 2 NRD1 2 LOC730668 2 MAPK4 2 MIR34C 2 MRPL16 2 NCR2 2 NRF1 2 LOC730811 2 MAPK7 2 MIR3618 2 MRPL19 2 NCR3 2 NRG3 2 LOC731275 2 MAPK8IP1 2 MIR3649 2 MRPL23 2 NCR3LG1 2 NRG4 2 LOC91450 2 MARCH8 2 MIR365A 2 MRPL52 2 NDN 2 NRN1L 2 LONP2 2 MARKS 2 MIR3675 2 MRPS18C 2 NDNL2 2 NRP2 2 LOXL1 2 MARCKSL1 2 MIR3680-1 2 MRPS2 2NDRG4 2 NSD1 2 LOXL1-AS1 2 MARCO 2 MIR3680-2 2 MRPS21 2 NDUFA13 2 NSRP1 2 LOXL2 2 MARS2 2 MIR3913-2 2 MRVI1 2 NDUFA4 2 NT5C 2 LPHN1 2 MARVELD1 2 MIR3960 2 MSMO1 2 NDUFA7 2 NT5DC2 2 LPPR2 2 MAT2A 2 MIR423 2 MST1P2 2 NDUFAF4 2 NTAN1 2 LPPR4 2 MAZ 2 MIR4258 2 MSX2P1 2 NDUFB8 2 NTN5 2 LRAT 2 MB21D2 2 MIR4289 2 MT1A 2 NDUFS5 2 NTRK3 2 LRCH1 2 MBD2 2 MIR4298 2 MT1DP 2 NDUFV1 2 NTSR1 2 LRIG3 2 MBD5 2 MIR4444-1 2 MT1L 2 NEAT1 2 NUB1 2 LRIT1 2 MBD6 2 MIR4461 2 MTA3 2 NEBL 2 NUDT1 2 LRP6 2 MBOAT7 2 MIR4468 2 MTCH1 2 NEK4 2 NUDT10 2 LRR1 2 MCAT 2 MIR4479 2 MTERF 2 NENF 2 NUDT21 2 LRRC14 2 MCC 2 MIR4489 2 MTERFD1 2 NET1 2 NUDT8 2 LRRC14B 2 MCCD1 2 MIR4505 2 MTHFD1 2 NEURL 2 NUP133 2LRRC2 2 MCHR2 2 MIR4513 2 MTHFD1L 2 NF1 2 NUP43 2 LRRC23 2 MCL1 2 MIR4520A 2 MTHFD2L 2 NFKB1 2 NUP62 2 LRRC32 2 MDFIC 2 MIR4651 2 MTIF2 2 NFKBIE 2 NUP98 2 LRRC34 2 MDM4 2 MIR4657 2 MTM1 2 NFKBIL1 2 NUPR1L 2 LRRC37A6P 2 ME1 2 MIR4669 2 MTPAP 2 NFYB 2 NUTF2 2 LRRC45 2 MED1 2 MIR4686 2 MTRR 2 NFYC 2 NXNL1 2LRRC4C 2 MED12L 2 MIR4726 2 MTUS1 2NGB 2 NXPH2 2 LRRC66 2 MED15 2 MIR4727 2 MUM1 2 NGEF 2 OCELl 2 LRRC71 2 MED20 2 MIR4728 2 MX1 2 NHEJ1 2 OCSTAMP 2 LRRC8B 2 MED22 2 MIR4736 2 MXD3 2 NHLRC1 2 ODC1 2 LRRC8E 2 MEF2A 2 MIR4749 2 MYADM 2 NHLRC2 2 ODF2 2LRRCC1 2 MEFV 2 MIR4751 2 MYCL1 2 NHLRC4 2 ODF3L1 2 LRRFIP1 2 MEGF10 2 MIR4786 2 MYEF2 2 NINJ1 2 OGFOD1 2 LRRIQ4 2 MEGF11 2 MIR5095 2 MYH16 2 NINL 2 OPN3 2 LRRK1 2 MEIS2 2 MIR548AE2 2 MYNN 2 NIPAL2 2 OPN5 2 LRRN4CL 2 MESP1 2 MIR548AO 2 MYO18A 2 NIPSNAP3B 2 OPRL1 2LRRTM4 2 METTL10 2 MIR5580 2 MYO18B 2 NKAPL 2 OR2T12 2LSM7 2 METTL17 2 MIR5584 2 MYO1B 2 NKIRAS2 2 OR4N3P 2 LTN1 2 MFGE8 2 MIR5691 2 MYO1D 2 NLK 2 OR5AP2 2 LTV1 2 MFSD10 2 MIR572 2 MYO3B 2 NLRC3 2 OR7C1 2 LUC7L3 2 MFSD11 2 MIR636 2 MYO9A 2 NLRP12 2 OR7E2P 2 LYPD1 2 MFSD2B 2 MIR641 2 MYOCD 2 NLRP2 2 ORA12 2 LYPD6 2 MGAT1 2 MIR7-2 2 MYOF 2NMB 2 ORAOV1 2LYRM2 2 MGC12916 2 MIR935 2 MYOM1 2 NMD3 20S9 2LYSMD4 2 MGC16275 2 MKRN3 2 MYPOP 2 NMI 2 OSBPL10 2 LZTR1 2 MGC23284 2 MKRN9P 2 MYSM1 2 NMNAT2 2 OSBPL6

2 OSCP1 2 PDZK1IP1 2 POLR3B 2 PSCA 2 RDH11 2 RPS15 2 OSGIN2 2 PDZRN3 2 POLR3GL 2 PSMA1 2 RDH12 2 RPS18 2 OTOS 2 PECAM1 2 POM121LiOP 2 PSMA4 2 RDH14 2 RPS20 2 OTUD7B 2 PEF1 2 POM121LiP 2 PSMB4 2 REEP3 2 RPS23 2 OXAlL 2 PELO 2 POMT1 2 PSMB9 2 RELT 2 RPS26 2 OXSR1 2 PEX14 2 PON 2 PSMC2 2 REM1 2 RPS4Y2 2 P2RX2 2 PEX19 2 POP7 2 PSMD14 2 RER1 2 RPS6KA2-IT1 2P2RX7 2PEX2 2POR 2PSMG2 2RFC3 2RPS6KA3 2P2RY13 2PEX5 2PORCN 2PTAFR 2RFFL 2RPS8 2 P2RY6 2 PFDN5 2 POU4F1-AS1 2 PTBP1 2 RFK 2 RPSAP58 2P4HB 2PGAM4 2POU5F1B 2PTCD3 2 RFPL2 2 RPUSD1 2 PABPC1 2 PGAP2 2 PP12613 2 PTCH2 2 RFTN1 2 RPUSD3 2 PABPC5 2 PGBD4 2 PPAPDC1B 2 PTGFRN 2 RFTN2 2 RRAGD 2PAD12 2PGD 2PPARG 2PTHLH 2RFX8 2RRH 2 PAD13 2 PGM3 2 PPFIA1 2 PTK7 2 RGAG1 2 RSBN1 2 PAEP 2 PHACTR2 2 PPIA 2 PTOV1 2 RGMA 2 RSPH9 2 PAFAH1B3 2 PHF21A 2 PPIE 2 PTOV1-AS1 2 RGPD3 2 RSPO1 2 PAFAH2 2 PHF23 2 PPIH 2 PTPN22 2 RGS22 2 RSPO3 2PAGE1 2PHKB 2PPP1R14B 2PTPN5 2 RGS3 2 RSPRY1 2 PAGE4 2 PHPT1 2 PPP1R15A 2 PTPN7 2 RGS6 2 RTEL1 2 PAIP2 2 P116 2 PPP1R37 2 PTPRCAP 2 RHBDL1 2 RTEL1 2 PAK3 2 PIAS2 2 PPP1R3F 2 PTPRG 2 RHCG TNFRSF6B 2 PAN2 2 PICK 2 PPP2CB 2 PUF60 2RHOG 2 RTN4RL1 2 PANK2 2 PIEZO1 2 PPP2R3A 2PURB 2 RHPN2 2 RTP1 2 PANK3 2 PIGQ 2 PPP2R5A 2PURG 2 RIF1 2 RUNDC3B 2 PAPLN 2 PIGR 2 PPP2R5C 2 PUSL1 2 RILP 2 RWDD2A 2 PAPSS2 2 PIGU 2 PPP3CB 2 PVR 2 RIMS4 2 RWDD2B 2 PAQR3 2 PlH1D1 2 PPP4C 2 PVRL1 2 RINL 2 RXFP3 2 PAQR5 2 PIK3CD 2 PPP5D1 2 PXMP2 2 RNASEK 2 RXFP4 2 PAQR6 2 PIK3R1 2 PPP6C 2 PXMP4 2 RNASEK- 2 SAAL1 2 PARD6B 2 PILRA 2 PRADC1 2 PYROXD1 C170RF49 2 SAFB2 2 PARD6G 2 PINK 2 PRDM1 2 QRFPR 2 RND2 2 SAMD3 2 PARD6G-AS1 2 PIP5K1C 2 PRDM10 2 RAB12 2 RNF10 2 SAMD9L 2 PARL 2 PITPNM3 2 PREB 2 RAB24 2 RNF126P1 2 SAP18 2 PASD1 2 PITRM1 2 PRELID2 2 RAB3B 2 RNF13 2 SARM1 2 PATL2 2 PWIL3 2 PREP 2 RAB3D 2 RNF130 2 SATL1 2 PAX5 2 PKD1L1 2 PRICKLE1 2 RAB4A 2 RNF144A 2 SBF1 2 PAX6 2 PKD2 2 PRICKLE2-AS1 2 RAB8B 2 RNF144A-AS1 2 SBF2-AS1 2 PAX9 2 PKN3 2 PRICKLE2-AS2 2 RABL2B 2 RNF145 2 SBSN 2 PAXIP1 2 PKNOX1 2 PRICKLE3 2 RAC2 2 RNF170 2 SCAND2 2 PCBD2 2 PKP1 2 PRIM1 2 RAC3 2 RNF175 2 SCARF1 2PCCA 2PKP3 2PRKAR2B 2RAD18 2 RNF182 2SCARNA13 2 PCDH20 2 PLCB3 2 PRKCA 2 RAD23A 2 RNF20 2 SCHIP1 2 PCDH9 2 PLCG1 2 PRKRIR 2 RAD50 2 RNF208 2 SCIMP 2 PCDHAC1 2 PLD4 2 PRLHR 2 RAD51L3-RFFL 2 RNF216 2SCOC 2 PCDHB1 2 PLD6 2 PROCAl 2 RAE1 2 RNF32 2 SCP2 2 PCDHB18 2 PLEK 2PROCR 2 RA114 2 RNF44 2 SCUBE2 2PCDHGC3 2 PLEKHA2 2PROSC 2 RANBP3 2 RNU6-19 2 SCUBE3 2 PCED1B 2 PLEKHG4 2 PRPF3 2 RANGRF 2 RNU6-28 2 SDAD1 2 PCGF1 2 PLEKHG4B 2 PRPF40B 2 RAP2B 2 ROPN1B 2 SDC4 2 PCID2 2 PLEKHG6 2 PRR18 2 RASA4CP 2 RPAP1 2 SDCBP2 2 PCK2 2 PLEKHM3 2 PRR19 2 RASGRP4 2 RPF1 2 SDCBP2-AS1 2 PCMT1 2 PLK2 2 PRR20A 2 RASL1OB 2 RPH3A 2 SEC11C 2 PCSK1N 2 PLK3 2 PRR20B 2 RASL11B 2 RPL13A 2 SEC14L4 2 PCYT1B 2 PLLP 2 PRR20C 2 RASSF9 2 RPL13AP5 2 SEC1P 2PDCL3 2PLS3 2PRR20D 2RBFOX2 2RPL23 2SEC22A 2 PDE12 2 PMS1 2 PRR20E 2 RBL1 2 RPL23AP53 2 SEC22B 2 PDE1C 2 PMS2P4 2 PRR22 2 RBL2 2 RPL23AP82 2 SEMA4A 2 PDE2A 2PNCK 2 PRR23B 2 RBM15 2 RPL27A 2 SEMA4B 2PDE3B 2PNMA3 2PRRC2C 2RBM17 2RPL3 2SENP8 2 PDIA3 2 PNMAL2 2 PRRG1 2 RBM20 2 RPL30 2 SEPT10 2 PDLIM1 2PNMT 2 PRRT2 2 RBM26 2 RPL36 2 SEPT14 2 PDLIM2 2PNOC 2 PRRT3 2 RBM4B 2 RPL39L 2 SEPT6 2 PDPK1 2 PNPLA2 2 PRRT3-AS1 2 RBM5 2 RPL4 2 SERBP1 2 PDPN 2 POC5 2 PRSS16 2 RBMXL1 2 RPL7A 2 SERF2 2 PDS5A 2 POLE 2 PRSS27 2 RBMY2FP 2 RPP21 2 SERPINB6 2 PDSS1 2 POLR1A 2 PRSS36 2 RBP7 2 RPS10 2 SERPINB8 2 PDXDC2P 2 POLR2G 2 PRTG 2 RCC2 2 RPS1O-NUDT3 2 SERPINB9

2 SERTM1 2 SLC41A3 2 SNORD24 2 SSR1 2 TBX10 2TMEM2 2 SETDlA 2 SLC43A3 2 SNORD32A 2 SSTR1 2 TBX3 2 TMEM200A 2 SETD5 2 SLC46A3 2 SNORD33 2 SSTR5 2 TBXA2R 2 TMEM211 2 SETMAR 2 SLC4A1AP 2 SNORD34 2 SSX4 2 TC2N 2 TMEM229A 2 SF3B5 2 SLC4A7 2 SNORD35A 2 SSX4B 2 TCAP 2 TMEM230 2 SFTPC 2 SLC51B 2 SNORD36A 2 SSX5 2 TCEAL5 2 TMEM241 2 SGCD 2 SLC5A8 2 SNORD36B 2 ST3GAL1 2 TCEAL7 2 TMEM40 2 SGK1 2 SLC6A1 2 SNORD36C 2 ST6GAL1 2 TCF15 2 TMEM43 2 SGMS2 2 SLC6A1-AS1 2 SNORD38A 2 ST6GAL2 2 TCF3 2 TMEM44 2SGSH 2SLC6A20 2SNORD38B 2ST6GALNAC3 2TCP1 2TMEM52B 2 SGSM1 2 SLC6A3 2 SNORD46 2 ST6GALNAC4 2 TDH 2 TMEM53 2SH3GL3 2SLC7A5 2SNORD54 2ST6GALNAC6 2TDRD9 2TMEM61 2 SH3KBP1 2 SLC7A8 2 SNORD55 2 ST8SIA2 2 TDRG1 2 TMEM65 2 SH3PXD2B 2 SLC9A1 2 SNORD83A 2 ST8SIA4 2 TEFM 2 TMEM72 2 SHANKS 2 SLC9A3R2 2 SNORD83B 2 ST8SIA5 2 TENM1 2 TMEM79 2 SHC1 2 SLC9A4 2 SNORD87 2 STAC 2 TEPP 2 TMEM8A 2 SHISA5 2 SLCO1B3 2 SNRNP27 2 STAG3L4 2 TERC 2 TMEM95 2 SHISA6 2 SLCO4A1 2 SNRNP48 2 STAT4 2 TERF21P 2 TMPRSS12 2SHROOM1 2 SLX4 2 SNRPB2 2 STC2 2 TERT 2 TMPRSS13 2SHROOM4 2 SMAD9 2 SNTB1 2 STEAP1B 2 TEX13B 2 TMPRSS3 2 SIDT2 2 SMAP2 2 SNX21 2 STEAP2 2 TFAP2A 2 TNFAIP3 2 SIGLEC10 2 SMARCA4 2 SNX22 2 STIP1 2 TFR2 2TNFRSF13B 2 SIGLEC12 2 SMARCAD1 2 SNX4 2 STK11IP 2 TGFBR2 2 TNFRSF6B 2 SIK2 2 SMARCALl 2 SNX6 2 STOML1 2 TGFBRAP1 2 TNFSF12 2 SIPAl 2 SMARCB1 2 SOCS1 2 STON2 2 TGIF2LY 2 TNIP2 2 SIRT2 2 SMARCD2 2 SOCS2 2 STOX1 2TGM6 2TNN 2 SIX4 2 SMC2 2 SOCS2-AS1 2 STOX2 2TH 2 TNNT1 2SKAP1 2SMC5 2SOCS3 2STPG2 2THAP4 2TNNT2 2 SKIV2L2 2SMG5 2 SOD2 2 STRA6 2THEM4 2 TNRC6A 2 SLA2 2SMG8 2 SOD3 2 STRBP 2THOC7 2 TNRC6B 2 SLC1A 2SMG9 2 SOLH 2 STUB1 2THRB 2 TNRC6C 2 SLC11A2 2SMOX 2 SOWAHC 2 STX16-NPEPL1 2 THY1 2 TOM1Li 2 SLC12A5 2 SMPD4 2 SOX11 2 STX7 2 TIAF1 2 TOP1P2 2 SLC16A1 2 SMPDL3A 2 SOX8 2 STXBP5L 2 TIALl 2TOPORS 2 SLC16A12 2 SMTNL2 2 SOX9 2 STYK1 2 TIE1 2 TOX3 2 SLC16A4 2 SNA12 2 SP3 2 SULF2 2 TIGD7 2 TP53BP1 2 SLC16A8 2 SNA13 2 SP6 2 SULT1Al 2 TIMM8A 2 TP53BP2 2 SLC19A2 2 SNAP91 2 SPAG11A 2 SUPT16H 2 TJP1 2 TPBG 2 SLC19A3 2 SNAPC5 2 SPARCL1 2 SUPT7L 2 TJP2 2 TPH1 2 SLClAl 2 SNAPIN 2 SPATA22 2 SVOPL 2 TK1 2TPM2 2 SLC1A3 2 SNAR-C1 2 SPATA5 2 SYCP2 2 TK2 2 TPPP 2 SLC1A6 2 SNAR-C2 2 SPDEF 2 SYNDIG1 2 TLK2 2 TRA2A 2 SLC20A1 2 SNAR-C5 2 SPDL1 2 SYNE3 2 TLR3 2 TRABD2B 2 SLC23A1 2 SNAR-E 2 SPEG 2 SYNGAP1 2 TLR4 2 TRAF1 2 SLC25A14 2 SNAR-G1 2 SPEN 2 SYNPO 2 TM9SF1 2 TRAF2 2 SLC25A17 2 SNAR-G2 2 SPG11 2 SYPL1 2 TMA16 2 TRAF3 2 SLC25A30 2 SNHG10 2 SPHK2 2 SYT11 2 TMBIM1 2 TRAF5 2 SLC25A33 2SNHG4 2 SPIRE1 2 SYT14 2 TMBIM6 2 TRAPPC1 2 SLC25A34 2SNHG6 2 SPIRE2 2 SYT17 2TMC4 2 TRIB3 2 SLC25A35 2 SNORA20 2 SPNS1 2 SYT2 2TMCC1 2 TRIM16 2 SLC26A1 2 SNORA21 2 SPNS2 2 SYT5 2TMCC3 2 TRIM26 2 SLC26A10 2 SNORA3 2 SPOCK2 2 SYT6 2 TMED1 2 TRIM38 2 SLC26A11 2 SNORA37 2 SPPL2B 2 SYT7 2 TMED9 2 TRIM44 2 SLC26A8 2 SNORA45 2 SPSB1 2 SYT8 2 TMEM102 2 TRIM60 2 SLC27A2 2 SNORA72 2 SQLE 2 SZRD1 2 TMEM130 2 TRIM69 2 SLC29A3 2 SNORA74A 2 SQSTM1 2 TAF4B 2 TMEM132E 2 TRIM72 2 SLC2A1-AS1 2 SNORA80B 2SRGN 2 TAF6L 2 TMEM134 2 TRIM73 2 SLC2A10 2 SNORD114-14 2 SRL 2 TAG 2 TMEM138 2 TRIM74 2 SLC2A13 2 SNORD114-15 2SRM 2 TAP1 2 TMEM155 2 TRIML2 2 SLC35A4 2 SNORD114-16 2SRMS 2 TBC1D10C 2 TMEM158 2 TRIP10 2 SLC35D2 2 SNORD114-17 2 SRP68 2 TBC1D13 2 TMEM168 2 TRIP4 2 SLC35F2 2 SNORD114-18 2 SRRD 2 TBC1D15 2 TMEM171 2 TRMT1OB 2 SLC38A11 2 SNORD114-19 2 SRSF1 2 TBC1D24 2 TMEM177 2 TRMT44 2 SLC38A3 2 SNORD16 2 SRSF2 2 TBC1D5 2 TMEM179B 2 TRMT61A 2 SLC38A4 2 SNORD18A 2 SRSF4 2 TBC1D8 2 TMEM181 2 TRNP1 2 SLC38A8 2 SNORD18B 2 SSC5D 2 TBK1 2 TMEM185B 2 TRPC1 2 SLC39A14 2 SNORD18C 2 SSH2 2 TBPL2 2 TMEM194B 2 TRPC4 2 SLC41A1 2 SNORD2 2 SSPN 2TBRG4 2 TMEM196 2 TRPC7

2 TRPM1 2 USP43 2 YWHAQ 2 ZNF548 1 AK3 1 BNIP1 2TRPM6 2 USP46 2 YY2 2 ZNF569 1 AKR7A2 1 BPIFA4P 2TRPM8 2USP47 2ZBBX 2ZNF570 1ALG9 1BSG 2TRPV3 2USP50 2ZBED6 2ZNF578 1ALK 1BTD 2TSC1 2USP8 2ZBP1 2ZNF596 1ALKBH5 1BTN3A3 2 TSC22D1 2 UST 2 ZBTB1 2 ZNF598 1ALKBH7 1 ClOorf2 2 TSC22D1-AS1 2 UTP11L 2 ZBTB25 2 ZNF615 1 ALMS1P 1 C1orf73 2 TSC22D3 2 UTP23 2 ZBTB33 2 ZNF618 1 ALOX12B 1 C12orf66 2 TSPAN14 2 VANGL1 2 ZBTB38 2 ZNF625 1 ALPI 1 C12orf7l 2 TSPAN15 2 VAX1 2 ZBTB4 2 ZNF625-ZNF20 1 AMBRAl 1 C14orf159 2 TSPY26P 2 VBP1 2 ZBTB41 2 ZNF644 1 AMOT 1 C14orf169 2 TSPY8 2 VCPIP1 2 ZBTB43 2 ZNF664- 1 AMPH 1 Cl5orf4O 2 TSSC1 2 VCX3B 2 ZBTB8A FAM101A 1 AMTN 1 C15orf56 2 TSSK3 2 VDAC1 2 ZC2HC1C 2 ZNF669 1 ANAPC1 1 Cl7orf5O 2 TSSK6 2 VPS18 2 ZC3H4 2 ZNF670- 1 ANKRD36 1 Cl7orf5l 2 TTC14 2 VPS41 2 ZC4H2 ZNF695 1 ANKRD65 1 C18orf42 2 TTC17 2 VPS52 2ZCCHC3 2 ZNF671 1ANO5 1 C18orf63 2TTC23L 2VPS53 2ZDHHC22 2ZNF681 1AP3S1 1 Cl9orfl2 2 TTC25 2 VTN 2 ZDHHC8P1 2 ZNF695 1 APBB1 1 Cl9orf4O 2 TTC30A 2 VTRNA1-2 2 ZEB1 2 ZNF703 1 APH1A 1 Clorfl94 2 TTC30B 2 VWA2 2 ZEB1-AS1 2 ZNF710 1 APITD1 1 Clorf213 2 TTC7A 2 VWA5B1 2 ZFAND2A 2 ZNF728 1 APITD1-CORT 1 Clorf54 2 TTC9B 2 WAS 2 ZFP14 2 ZNF738 1APOC1 1 C20orfl11 2 TTLL10 2 WASF2 2 ZFP161 2 ZNF75A 1AQR 1 C2orf69 2 TTLL13 2 WBP11P1 2 ZFP41 2 ZNF783 1ARC 1 C2orf7O 2 TTLL6 2 WDFY2 2 ZFP82 2 ZNF800 1 ARF5 1 C3AR1 2 TTPAL 2 WDR1 2 ZFR2 2 ZNF827 1 ARHGAP44 1 C3orfl8 2 TTYH2 2 WDR17 2 ZFYVE27 2 ZNF835 1ARHGAP9 1 C3orf2O 2 TUBAlA 2 WDR26 2 ZHX2 2 ZNF836 1 ARHGEF6 1 C3orf62 2TUBGCP3 2 WDR45 2 ZHX3 2 ZNF84 1 ARL3 1 C6orf7O 2 TUSC3 2 WDR48 2 ZKSCAN1 2 ZNF878 1 ARL5A 1 C7orf63 2 TUSC5 2 WDR54 2ZKSCAN3 2 ZNHIT2 1ARMC2 1 C7orf73 2 TYR 2 WDR5B 2 ZMAT2 2 ZNHIT3 1ARMCX2 1 C9orf129 2 U2AF1 2 WDR67 2 ZMAT4 2 ZNRF3 1 ARPP19 1 C9orfl31 2 UBAC1 2 WDR73 2 ZMAT5 2 ZRSR2 1ARSF 1 C9orfl35 2 UBAC2-AS1 2 WDR82 2 ZNF136 2 ZSCAN1 1ASAH2B 1 C9orfl71 2 UBAP2 2 WDR86 2 ZNF140 2 ZSCAN23 1 ASB12 1CACNA1G 2 UBE2E2 2 WDTC1 2 ZNF17 2 ZSCAN30 1 ASB9 1 CACNB2 2 UBE2K 2 WFDC3 2 ZNF185 2 ZSCAN5B 1 ASRGL1 1 CACTIN 2 UBE2M 2 WFS1 2 ZNF204P 2 ZWILCH 1 ASTL 1CACYBP 2 UBE2Z 2 WIBG 2 ZNF212 2 ZXDB 1 ASTN1 1 CALCA 2 UBFD1 2 WIPF2 2 ZNF221 2 ZXDC 1ATAD2B 1 CAPN7 2 UBLCP1 2 WIPF3 2 ZNF222 1AADAT 1 ATF3 1 CASKIN2 2 UBN1 2 WIP11 2 ZNF229 1 AAK1 1 ATP12A 1 CCDC169 2 UBOX5 2 WIP12 2 ZNF235 1AANAT 1ATP4A 1 CCDC28B 2 UBXN4 2 WISP1 2 ZNF236 1AASDH 1 ATP5SL 1 CCDC47 2 UHMK1 2 WISP2 2 ZNF264 1AASDHPPT 1 ATP6AP1 1 CCDC60 2 UHRF1 2 WNK4 2 ZNF280B 1ABCA9 1 ATP6VOA2 1 CCDC88A 2 UHRF2 2 WNT16 2 ZNF280D 1 ABCC13 1 ATP6VOE1 1 CCDC97 2 UIMC1 2 WRN 2 ZNF292 1 ABCG1 1 ATP6V1G1 1 CCL 2 ULK4 2 WSB1 2 ZNF324 1 ABHD11-AS1 1 ATP6V1G2- 1 CCNT1 2 UNC119 2 WSCD2 2 ZNF331 1 ABI3BP DDX39B 1 CCR9 2 UNC45A 2 VWVC2-AS2 2 ZNF34 1 ACAT2 1 ATP8B5P 1 CD160 2 UNC50 2 WWOX 2 ZNF367 1 ACCS 1 ATRNL1 1 CD276 2 UNC5C 2 XAGE5 2 ZNF395 1 ACOT13 1 ATXN7L3B 1 CD80 2 UNKL 2 XPA 2 ZNF414 1 ACOX1 1 AVPR2 1 CD84 2 UNQ6494 2XPOT 2 ZNF415 1ACSBG2 1 AXIN1 1 CDC42 2 UPF1 2 XYLT1 2 ZNF425 1 ACSF2 1 B3GALT4 1 CDC42EP3 2 UPF3A 2 YAE101 2 ZNF44 1 ACTC1 1 B3GAT1 1 CDK11B 2UPK2 2YAF2 2ZNF445 1ADAM32 1BAG4 1CDK5R2 2 UQCRFS1 2 YBX2 2 ZNF497 1 ADAMTS13 1 BBS7 1CEACAM5 2USF2 2YEATS2 2ZNF507 1ADAMTS15 1BCKDHB 1CEL 2 USH1C 2 YIF1A 2 ZNF511 1 ADCK3 1 BCL2L15 1 CELSR1 2 USP16 2 YLPM1 2 ZNF512 1ADCYAP1 1 BCORP1 1CENPA 2 USP19 2 YPEL2 2 ZNF513 1 ADRA2B 1 BEND3 1 CEP85 2 USP2 2 YPEL3 2 ZNF518A 1 AGPAT3 1 BEST2 1 CEP89 2 USP24 2 YTHDC1 2 ZNF530 1 AIML 1 BLNK 1 CERKL 2 USP39 2 YTHDF2 2 ZNF536 1 AIRE 1 BMPR1A 1 CERS6

1 CES1 1 DEFB121 1 FAM179A 1 GNAT1 1 HYDIN 1 LINC00487 1 CES2 1 DEFB133 1 FAM195B 1 GNG4 1 IBTK 1 LINC00578 1 CFB 1 DENND5A 1 FAM196A 1 GNL1 1 IFITM1 1 LINC00582 1 CFHR5 1DEPDC7 1 FAM196B 1 GNL3 1 IFLTD1 1 LINCO0605 1 CFI 1 DERA 1 FAM19A3 1 GOLGA2P5 1 IGF1R 1 LINC00673 1 CFTR 1 DGAT2L6 1 FAM19A4 1 GPATCH1 1 IGSF5 1 LNP1 1 CHAC1 1 DGCR10 1 FAM200B 1 GPBAR1 1 IGSF6 1 LNX1 1CHAD 1 DHRS7 1 FAM211A 1 GPC3 1 IKZF3 1 LNX1-AS1 1 CHD8 1 DHRS9 1 FAM212B 1 GPD1 1 ILlORA 1 LOC100128264 1 CHI3L2 1 D102 1 FAM214A 1 GPR64 1 IL17B 1 LOC100128292 1 CHMP2B 1 D102-AS1 1 FAM222B 1 GPR88 1 IL1R1 1 LOC100129518 1 CHRDL2 1 D103 1 FAM57A 1 GPR98 1 IL1RL2 1 LOC100130476 1 CHRM2 1 D1030S 1 FAM66A 1 GPRASP1 1 ILDR2 1 LOC100130539 1 CHRM3 1 1 FAM91A1 1 GPRC5D 1 IQCC 1 LOC100130700 1 CHRNA6 DKFZp686K1684 1 FAM92B 1 GPX1 1 IQSEC2 1 LOC100131138 1 CHRND 1 DKK3 1 FAM96B 1 GPX5 1 IRF8 1 LOC100132078 1 CLDN11 1 DLL1 1 FANCI 1 GREB1 1 IRX6 1 LOC100132354 1 CLEC12B 1 DMBT1 1 FARP2 1 GRHL3 1 ISG20 1 LOC100132987 1 CLINT1 1 DNAJB5 1 FARS2 1 GRIA1 1 ITCH 1 LOC100133985 1 CLRN1 1 DNAJC5 1 FBP1 1 GRIPAP1 1 ITFG2 1 LOC100134868 1 CMSS1 1 DNAJC5B 1 FBX011 1 GRM8 1 ITIH3 1 LOC100240735 1 CMTM7 1 DNPEP 1 FBX022 1 GSTM5 1JOSD2 1 LOC100268168 1 CMTM8 1 DOCK2 1 FBX03 1 GTF3A 1 KCNA7 1 LOC100288346 1 CNPY1 1 DOK 1 FBX041 1 GZMB 1KCNAB2 1 LOC100289019 1 CNRIP1 1 DPEP1 1 FCRL5 1 GZMM 1 KCNH3 1 LOC100302640 1 COG2 1 DPPA4 1 FEZF1 1 H2AFB1 1 KCNJ4 1 LOC100335030 1 COLlAl 1 DPY19L1 1 FEZF1-AS1 1 H2AFB3 1 KCNJ9 1 LOC100498859 1 COL1A2 1 DPYS 1 FIBIN 1 HACE1 1 KCNK15 1 LOC100505783 1 COL6A4P1 1 DSC3 1 FIBP 1 HACL1 1 KCNK17 1 LOC100506746 1 COL8A2 1 DTNA 1 FILIP1L 1 HAT1 1 KDM2A 1 LOC100616530 1 COLEC11 1 DUSP14 1 FIP1Ll 1 HDC 1 KDM4C 1 LOC100652791 1 COR02B 1 DUSP27 1 FKBP7 1 HEATR4 1 KIAA0319 1 LOC146880 1 CPEB2 1 DUSP3 1 FLJ22184 1 HEMK1 1 KIF5C 1 LOC151174 1 CPSF1 1 DUT 1 FLJ33065 1 HERC2P2 1 KITLG 1 LOC282997 1 CRADD 1 EBF4 1 FLJ34208 1 HEXA 1 KLHDC4 1 LOC283143 1 CREBZF 1 ECM1 1 FLJ39051 1 HEXA-AS1 1 KLHL18 1 LOC283335 1 CREM 1 EDC3 1 FLJ44635 1 HEY1 1 KLHL3 1 LOC286190 1 CRHBP 1 EFCAB13 1 FN1 1 HHAT 1 KLHL30 1 LOC338817 1 CRTC1 1 EFCAB2 1 FNDC3A 1 HIATL1 1 KLHL32 1 LOC344595 1 CSRP1 1 EFNB2 1 FNTA 1 HIC1 1 KRT12 1 LOC400456 1 CST7 1 EGF 1 FOXN3 1 HIST1H2AL 1 KRT27 1 LOC401127 1 CSTA 1 EGFL6 1 FREM1 1 HIST1H2BF 1 KRT8 1 LOC439990 1 CTDNEP1 1 EGOT 1 FTSJD1 1 HIST2H2AB 1 KRT84 1 LOC440028 1 CTTN 1 EGR4 1FUNDC2 1 HIST2H2BE 1 KRTAP10-10 1 LOC494558 1 CTTNBP2 1 E124 1 FXR2 1 HLA-B 1 KRTAP10-2 1 LOC642852 1 CTXN1 1 EIF2C4 1FZD9 1 HLA-C 1 KRTAP5-5 1 LOC643387 1 CUL2 1 EIF3G 1 GAL3ST2 1 HMGA2 1 KRTCAP2 1 LOC644961 1 CUL3 1 ELK3 1GALK2 1 HMGXB3 1 LACE1 1 LOC646903 1 CWH43 1 ELMOD1 1 GALNS 1 HNRNPUL1 1LAMTOR3 1 LOC650226 1 CYBRD1 1 ELP5 1 GALNT4 1 HOPX 1 LAPTM4B 1 LOC728024 1 CYFIP1 1 EME1 1 GALNT6 1 HOXB4 1 LCA5L 1 LOC728218 1 CYPlAl 1 EMILIN3 1 GALNTL6 1 HOXB9 1 LCE1E 1 LOC728613 1 CYP2D7P1 1 EMP2 1 GBA3 1 HOXC-AS5 1 LCN15 1 LOC729020 1 CYP39A1 1 EPB41L3 1 GBP3 1 HOXC12 1 LCN2 1 LOC729059 1 CYP4F11 1 EPS8L1 1 GCC1 1 HOXC13 1 LCN6 1 LOC732275 1 CYP4F8 1 ERN1 1 GCHFR 1 HOXC8 1 LGALS1 1 LOXL3 1 DACT3 1 ETV7 1 GDAP2 1 HOXD10 1 LGALS17A 1 LOXL4 1DAGLB 1F2RL1 1GDF15 1 HPRT1 1LGALS8 1LPHN3 1 DAK 1 F8A1 1 GD11 1 HPSE 1 LGALS8-AS1 1 LPO 1 DALRD3 1 F8A2 1 GF11B 1 HPSE2 1 LG13 1 LRPAP1 1 DAP 1 F8A3 1 GID8 1 HSD17B12 1 LHB 1 LRRC3B 1 DAPP1 1 F9 1 GIGYF2 1 HSPA12A 1 LHFPL2 1 LRRC55 1 DCAF5 1FAHD2B 1 GIMAP2 1 HSPA1A 1LHX4 1LRRN2 1 DCDC2B 1 FAM100B 1 GIMAP7 1 HSPA1L 1 LIMS1 1 LSM1 1 DDX20 1 FAM105A 1 GIPR 1HTR3D 1 LINCO0051 1 LYPD5 1 DDX39B 1 FAM135B 1 GLRA4 1 HTR5A 1 LINCO0189 1 MAML1 1 DDX42 1 FAM13B 1 GLTPD2 1 HTRA3 1 LINCO0304 1 MANBA 1 DEFA1OP 1 FAM169B 1 GNA13 1 HUWE1 1 LINC00472 1 MAP2K1

1 MAP2K6 1 MRPL28 1OR8K1 1POFUT2 1RNASE12 1SLC47A1 1 MAPK11 1 MRPL43 1 OR8S1 1 POGLUT1 1 RNASE6 1 SLC48A1 1 MAPK15 1 MRPL45 1 OSBPL1O-AS1 1 POGZ 1 RNF126 1 SLC4A8 1 MASTL 1 MS4A8B 1 OSBPL11 1 POLA2 1 RNF128 1 SLC5A1 1 MAT2B 1 MSH3 1 OTOF 1 POLD3 1 RNF133 1 SLC5A7 1 MB 1 MSH6 1 OTOP3 1 POLDIP3 1 RNF138P1 1 SLC6A18 1 MCM3 1 MSRB3 1OTP 1 POLK 1RNF144B 1 SLC6A4 1 MCTP1 1 MSX2 1OTUD7A 1 POLR1B 1 RNF148 1 SLC7A14 1 MEAF6 1 MT1E 1 P2RY11 1 POLR2C 1 RNF168 1 SMG7 1 MECOM 1 MT2A 1 P2RY12 1 POLR3H 1 RNF7 1 SMG7-AS1 1 MED12 1 MTOR 1 P2RY14 1 POU6F2 1 RP1L1 1 SNAR-C3 1 MED18 1 MUC15 1 P2RY2 1 PPFIBP1 1 RPL11 1 SNHG16 1MEF2C 1MXD4 1PABPC4L 1PPIL1 1RPL24 1SNHG3 1 MEIS1 1 MYB 1 PAD11 1 PPIL2 1 RPL26 1 SNORA11B 1 MEIS1-AS3 1 MYBPHL 1 PAK 1 PPIL4 1 RPL26L1 1 SNORA4 1MEPCE 1MYF6 1PAK4 1PPM1B 1RPL8 1SNORA63 1 METTL24 1 MYL10 1 PAK6 1 PPM1F 1RPRD2 1 SNORD19B 1 METTL3 1 MYLK4 1PAPPA2 1PPM1J 1RRAS2 1SNORDlA 1 MFSD3 1 MYO15B 1 PAQR8 1 PPP1CA 1 RRP12 1 SNORD1B 1 MFSD7 1 MYOC 1PARVB 1 PPP1R27 1 RRP7B 1 SNORD1C 1 MGA 1 MYRIP 1 PBRM1 1 PPP2R5D 1 RSAD1 1 SNORD69 1 MGP 1 MYT1 1 PCDHB11 1 PQLC2 1 RSU1 1 SNORD84 1 MIAT 1 MZB1 1 PCED1B-AS1 1 PRAF2 1 RUFY4 1 SNRPG 1 MICB 1NANOS3 1 PCMTD1 1 PRDX1 1 RYBP 1 SNX27 1 MID1 1 NAT8 1PCMTD2 1 PRKCD 1 SlOAll 1SNX9 1 MIR1207 1 NBLA00301 1 PCYT2 1 PRKD1 1 SACS 1 SOCS6 1 MIR1307 1 NCBP1 1 PDCD11 1PRKD3 1 SAFB 1 SORD 1 MIR1322 1 NCOA5 1 PDCD4 1 PROB1 1 SAMD12 1 SOX2-OT 1 MIR193B 1 NDST1 1 PDCL2 1 PROM1 1 SAMM50 1 SOX6 1 MIR196A2 1 NDUFAl0 1 PDE7A 1 PRPF18 1 SCAF8 1SPACA7 1 MIR200A 1 NDUFAF3 1 PDE8A 1 PRR15L 1 SCEL 1 SPATS2 1 MIR218-2 1 NEDD9 1PDGFRA 1 PRR3 1 SCG5 1SPEM1 1 MIR22 1 NEK5 1 PECR 1 PRRX1 1 SCML2 1SPHKAP 1 MIR2276 1 NFIB 1 PEL12 1 PRSS12 1 SDE2 1 SPINT1 1 MIR22HG 1 NFKBIA 1 PEX10 1 PRSS23 1 SDHAF1 1 SPOP 1 MIR3127 1 NHP2L1 1 PEX6 1 PSMA3 1 SEC63 1 SPTBN1 1 MIR3142 1 NLGN4Y 1 PFKL 1 PSMD1 1 SECISBP2L 1 SRD5A1P1 1 MIR3646 1 NMNAT1 1 PFN2 1 PSMF1 1 SEMA4D 1 SRGAP1 1 MIR424 1 NODAL 1 PGAP1 1PTCHD2 1 SEMA6D 1 ST3GAL4 1 MIR425 1 NOS1 1 PGAP3 1PTCRA 1 SEPP1 1ST6GALNAC1 1 MIR429 1 NOTO 1 PGLYRP4 1PTEN 1 SEPT8 1 ST8SIA1 1 MIR4314 1 NOTUM 1 PGM1 1PTGER1 1 SERPINA5 1STARD9 1 MIR4500HG 1 NOX 1PHACTR4 1 PTP4A3 1 SF3B1 1STEAP1 1 MIR4508 1 NPAS2 1 PHF17 1 PTPN3 1 SFXN2 1 STIM1 1 MIR4632 1 NR2C2 1 PHOX2A 1PURA 1 SH2D1A 1 STK17A 1 MIR4716 1 NR4A1 1 PHOX2B 1 PXN 1 SH2D2A 1 STK39 1 MIR4795 1 NR4A2 1 P14KB 1QPRT 1 SH3BGR 1STMN2 1 MIR4800 1 NRBP1 1 PIGZ 1 QSOX2 1 SH3BGRL3 1STMN3 1 MIR503 1NRCAM 1 PIK3R5 1 RAPGEF4 1SHBG 1STXBP6 1 MIR521-2 1 NRM 1 PWIL4 1 RAPGEF4-AS1 1SHC2 1 SUCLA2 1 MIR548N 1 NT5C2 1 PLAC2 1 RARRES2 1 SHISA8 1 SURF6 1 MIR567 1 NT5C3 1 PLAC8 1 RARRES3 1SHQ1 1 SUV39H1 1 MIR592 1 NTN1 1 PLCB4 1 RBM12B 1 SIK3 1 SYCP2L 1 MIR600 1 NTRK1 1 PLCD1 1 RBM12B-AS1 1 SIRPA 1 SYNE1 1 MIR600HG 1 NUCB2 1 PLEK2 1 RBM38 1 SIRT7 1TAAR6 1 MIR626 1 NUPL1 1PLEKHA3 1 RBMY2EP 1 SKA3 1 TAB2 1 MIR642A 1NXPH4 1 PLEKHG1 1RBPMS2 1 SKIDAl 1TAC3 1 MIR648 1 OAS3 1 PLK1 1 RCAN1 1 SLAMF8 1TACC1 1 MIR9-1 1 OAZ1 1 PLSCR3 1 RESP18 1 SLC14A1 1TANC1 1 MIR9-3 1 OIT3 1 PM20D1 1 RFX2 1 SLC17A3 1 TAS1R1 1 MITF 1 OLFM4 1 PNLIPRP1 1 RFXAP 1 SLC17A8 1TBC1D2 1 MMP2 1 OLIG1 1 PNMAL1 1 RGAG4 1 SLC22A1 1 TBL1XR1 1 MMP3 1 OR1Fl 1 PNN 1 RGS17 1 SLC23A2 1 TBPL1 1 MMP7 1 OR2W3 1 PNPLA4 1 RGS2 1 SLC25A27 1 TBX20 1 MORC2-AS1 1 OR52B6 1 PNPLA7 1 RGS9 1 SLC25A52 1 TBX4 1 MPEG1 1 OR52K2 1 POC1B 1 RIMBP2 1 SLC39A4 1 TBXAS1 1 MPP5 1 OR52N2 1 POC1B- 1 RIMS2 1 SLC43A1 1 TCF7L2 1 MRO 1 OR6P1 GALNT4 1 RNASE11 1 SLC46A2 1 TDP2

1 TENC1 1 TMEM206 1 TRIM55 1 UBE2N 1 WNT11 1 ZNF148 1 TESC 1 TMEM217 1 TRMT11 1 UBXN10 1 WNT4 1 ZNF234 1 TEX2 1 TMEM222 1 TSHR 1 UGT3A2 1 WNT7B 1 ZNF257 1 TEX22 1 TMEM31 1TSNARE1 1 UHRF1BP1 1 WWP1 1 ZNF296 1 TEX33 1 TMEM39A 1 TSPAN18 1 ULBP2 1 XIRP1 1 ZNF322 1TFAP2B 1TMPRSS2 1TSPEAR 1ULBP3 1XKR5 1ZNF385D 1 TGFBR1 1 TMSB4Y 1 TSTD2 1 ULK1 1 XPO6 1 ZNF436 1TGFBR3 1TMX1 1TTBK1 1UPF2 1YEATS4 1ZNF468 1 THSD4 1 TNFSF10 1 TTC32 1 USMG5 1 YME1L1 1 ZNF485 1 TIMM44 1 TNN13K 1 TTC4 1 USP14 1 ZAR1 1 ZNF518B 1TLR10 1TNS4 1TTC9 1USP36 1ZBED3 1ZNF541 1 TLR8 1 TOMM70A 1 TTF1 1 UTRN 1 ZBED3-AS1 1 ZNF583 1 TLR8-AS1 1 TOP3B 1 TTLL5 1 VAV1 1ZBTB48 1 ZNF624 1 TLX2 1 TPH2 1 TTTY14 1 VAV2 1 ZCWPW1 1 ZNF704 1 TM4SF18 1 TP11 1 TTYH1 1 VMA21 1 ZDHHC20 1 ZNF740 1 TMEM150B 1 TPK1 1TUBGCP4 1 VMO1 1 ZFAND1 1 ZNF793 1 TMEM169 1 TRAF31P1 1TUBGCP6 1 VTRNA1-3 1 ZIC2 1 ZNF80 1 TMEM17 1TRAM1 1 TXK 1 VWC2 1ZKSCAN2 1 ZNF83 1 TMEM176A 1TRAPPC6B 1 TXLNG 1 WDR19 1ZMYM4 1ZPBP2 1 TMEM176B 1TRDN 1TXN2 1 WDR81 1ZMYM5 1 ZSCAN12P1 1 TMEM182 1TREM1 1TXNRD1 1 WFIKKN2 1 ZMYND11 1ZSCAN29 1 TMEM200C 1 TRIM46 1 UAP1L1 1 WNT1OA 1 ZNF107

Table 3: Poor Embryo-Quality Genes, Ranked 35 VIPR2 21 FAM53A 20SNRPN 19 18 C6orf201 18 MCF2L2 34 NRXN2 21 FLJ36000 20 TMEM74 LOC100287834 18 CCDC121 18 MDGA2 30 APOL6 21 HIST1H1T 20TRABD 19 LOC653160 18CEBPE 18 MESTIT1 30 SMAP1 21 LINC00607 20 TRIM10 19 LRP4-AS1 18CTNNB1 18 MR11 28SNTG2 21 LOC729121 20 TRIM15 19 LRRC7 18 CYB5D1 18 MTX2 27 KCNQ1 21 MEST 20 ZC3H11A 19 LY86 18DDAH2 18 N6AMT2 27TNXB 21PABPC1P2 20ZFHX4 19MAD1L1 18 DDX3Y 18 NPRL3 27 ZBTB46 21 PCDHA5 19 ACE2 19 MAGEA12 18 DNHD1 18 NR5A2 26 HDAC4 21PCDHA6 19 ADAMTS20 19 MAGEB2 18 FAM184B 18 NT5C1B 26 PDZD2 21 PLAGL1 19 ADRBK1 19 MDC1 18 FAM217A 18 OPA1 26 RPTOR 21 PRPS1Li 19 ARHGEF10 19 MREG 18FARP1 18 OR2AE1 25 C14orf79 21 PSMD14 19 BLCAP 19 NAP1L5 18FKBP6 18 PAGE2B 25 HCG17 21 RABIF 19 C13orf45 19 NCK2 18 FTHL17 18PCDHA8 25HCG18 21RGPD4 19C1QTNF7 19NNAT 18GATA6 18PCDHGA1 25 TBC1D1 21 STK19 19 CARD11 19 NSUN7 18 GPN1 18 PCDHGA10 25 TRIM39 21 TAF1C 19 CCDC169- 19 NT5C1B- 18 GPR50 18 PCDHGA11 25 TRIM39- 21 XXYLT1 SOHLH2 RDH14 18 GRIN2D 18PCDHGA2 RPP21 21 ZC3H12D 19 CCDC79 19 OPRD1 18 GZF1 18PCDHGA3 24 CALHM1 20 ANK1 19 CNTROB 19 OR10C1 18 HAPLN1 18PCDHGA4 24 CSMD1 20ANO3 19 COX8C 19 PCDHA7 18 HDGFL1 18PCDHGA5 24 TXNDC15 20 BEX1 19 CSAG1 19 PRDM16 18 HGC6.3 18PCDHGA6 23 LRP4 20 DIP2C 19 CTAGE1 19 PTPRD 18 HIST1H1A 18PCDHGA7 23 PCDHA1 20 DYNC1LI1 19 CUX1 19 QRSL1 18 HIST1H3A 18PCDHGA8 23 PCDHA2 20 HOXA3 19 DLGAP2 19 RTN41P1 18 HIST1H4A 18PCDHGA9 23 RNF220 20 HYMAI 19 EIF2C1 19 S100A9 18 HS3ST1 18PCDHGB1 22 DUSP21 20 ID3 19 EXOSC9 19 SLC9A3 18HSPG2 18PCDHGB2 22 ITGAE 20 JARID2 19 FBXL20 19 SOHLH2 18 IL17RA 18PCDHGB3 22 LOC643406 20 LOC401242 19FMN2 19 TCEB3B 18 IL18 18PCDHGB4 22 LRRC37BP1 20LRBA 19FTMT 19 TNFRSF18 18 INPP5A 18PCDHGB5 22 NFIC 20 MAB21L2 19 GNG12-AS1 19TUBB 18KCNH5 18PCDHGB6 22 PCDHA3 20 MAGEB1 19 GPR123 19 UNC79 18KDM6B 18PCDHGB7 22 PCDHA4 20 MAPK10 19 GPX6 18 ACVR1C 18 KIAA1551 18PDXDC1 22 POMT2 20 MIR148A 19 HERC3 18 ADAMTS2 18 KIFC1 18 PPT2 22 SLAIN 20 NGFRAP1 19 HLA-A 18AGAP1 18LAMA2 18 PPT2-EGFL8 22 TRAPPC12 20 NOS3 19 HSPA7 18ANTXR2 18 18 PRRT1 22 WFDC1 20PACRG 19 KATNAL2 18BCYRN1 LOC100506451 18 RAI1 21ADAD2 20PENK 19 KCNAB3 18 BLOC1S5- 18 LOC442028 18 RASSF8 21 C3orf24 20 RAD51B 19 KIF26B TXNDC5 18 LOC641367 18 RBCK1 21 CALD1 20 SKI 19 LINC00340 18BRDT 18LRFN1 18 RBFOX1 21 COL23A1 20 SMYD3 18 C2orf47 18 LY9 18 RELB

18 RNU6-81 17 FAM9A 17 NRSN1 17 ZFP64 16 DAB1 16 KLF8 18SENP3 17 FAM9B 17 PCDHGA12 17 ZGLP1 16 DACH1 16 KRBA1 18 SENP3-EIF4A1 17 FASTK 17 PDP1 17 ZIC5 16 DAZL 16 KRT28 18 SLMO1 17 FBXL18 17 PLEC 17 ZNF219 16 DCAF4L1 16 L3MBTL4 18SMAD6 17 FRMD1 17 PLEKHA5 17 ZNF354A 16 DCAF4L2 16 LATS2 18SPERT 17 GAS7 17 PNLDC1 17 ZNF521 16 DDX53 16 LDHD 18 SSTR5-AS1 17 GIMAP1 17 PNMA1 17 ZNF532 16 DEF6 16 LFNG 18 STK3 17 GIMAP1- 17 PPARA 17 ZNF579 16 DIAPH2 16 LINC00473 18 SVIL GIMAP5 17 PPP1R18 17 ZNF668 16 DIRAS3 16 LINC00668 18TAPBP 17 GLTSCR1 17PRDM9 17 ZNF678 16 DMRTB1 16 LMF1 18 TEX12 17 GNAS 17 PRELP 17 ZNF714 16 DNAH12 16 LMTK3 18TMEM88 17 GPR39 17 PSORS1C1 17 ZNF735 16 DNAJA4 16 18 TRIM50 17 GRIN2B 17PTPRCAP 17 ZNF775 16 DVL3 LOC100128750 18TXLNA 17 HLA-DQB2 17 PTPRN2 17 ZNF843 16 EFHC2 16 18TYW5 17 HLTF 17 QRICH2 17 ZNF865 16 EFNA2 LOC100129794 18 WDR27 17 HLTF-AS1 17 RARG 16 ABCA7 16 EHBP1 16 18 ZBTB22 17 HNRNPA1L2 17 RBPMS 16 ABHD8 16 EHD4 LOC100132215 18 ZNF100 17 HOXA4 17 REPIN1 16 ACOT4 16 EXOC4 16 18 ZNF696 17 HTR2C 17 RFPL3 16 ACSL5 16 FAM13C LOC100506713 18 ZNF74 171NF2 17 RFX1 16 ADARB2 16 FAM151B 16 17ABR 17INPP5F 17 RGS7 16ADGB 16 FAM172A LOC100507266 17 ADAD1 17ITPR1 17 RNF103- 16 ALOX12P2 16 FAM189A1 16 17 ADCY10P1 17 KCNJ14 CHMP3 16 ALOX5AP 16 FAM197Y2 LOC100507463 17AGA 17 KCNQ1OT1 17 RNF113B 16 AMFR 16 FAM197Y5 16 LOC116437 17 AGAP3 17 KEAP1 17 RNU6-71 16 ANKFY1 16 FAM204A 16 LOC340094 17 AKAP12 17 KHDC1 17 RPL22L1 16 AP2M1 16 FAM47B 16 LOC389641 17 AKT3 17 KIAA0146 17 RPS6KA2 16 APC 16 FAM48B1 16 LOC401164 17 ANKRD20A9P 17 KIAA2013 17 RPS6KA4 16 APCDD1L 16 FAT3 16 LOC643441 17 ANKRD30A 17 KIF16B 17 SGK223 16 ARHGEF4 16FHOD3 16 LOC654433 17ANO1 17 KLHL13 17 SHCBP1L 16 ATP10A 16 FIZ1 16 LOC729177 17APBA1 17KLHL20 17SLC12A6 16 BCL2L2- 16 FLJ42875 16 LOC731789 17AR 17KPRP 17SLC9C1 PABPN1 16FPGT 16LPCAT1 17 ARHGAP27 17 LINC00221 17 SORCS2 16BCOR 16 FPGT-TNN13K 16 LRFN3 17 ARHGEF17 17 LINC00359 17 SOX30 16 BMP3 16 GALNT9 16 LRRC38 17 ARID3A 17 LINC00482 17 SPDYC 16 BTBD19 16 GDF1 16 LRRIQ3 17 ASIC4 17 17 SPRED3 16 Cl0orf32- 16 GGN 16LRRTM3 17 ATP11A LOC100128714 17 SRGAP3 AS3MT 16 GHRL 16 LUZP4 17 BEND2 17 17 STAU2 16 Cl0orf7l 16 GL12 16 MAGEB6 17 BEX2 LOC100133612 17 STK31 16 C11orf2l 16 GML 16 MCCC1 17BHMT 17 17 TBC1D16 16 Cl1orf52 16 GNA12 16 MCF2L 17 BOLL LOC100286922 17 TCTN1 16 C17orf98 16 GNAS-AS1 16 MEG3 17 BRCA1 17 17 TECTA 16 Clorfl46 16 GNG7 16 MINK1 17 BRD9 LOC100873065 17 TEX28 16 C1orf228 16 GRASP 16 MIR1237 17 Cl0orf47 17 LOC153684 17 TFAP2E 16 C22orf45 16 GRB10 16 MIR143HG 17 C12orf40 17 LOC219731 17 TKTL1 16 C2orf65 16 GRWD1 16 MIR145 17 Clorf6l 17 LOC285768 17 TMEM237 16 C4orf22 16 GSPT1 16 MIR4648 17 C3orf77 17 LOC339822 17TMUB1 16 C7orf72 16 GSTCD 16 MKX 17 C6orf147 17 LOC401010 17 TNRC18 16 C9orf156 16 HIPK2 16 MMP28 17 C7orf50 17 LST1 17 TRERF1 16 CALN1 16 HIST1H2BH 16 MORC1 17 C8orf22 17 LTB 17 TRIO 16 CAPS2 16 HIST1H4G 16 MRPL34 17 CACNA11 17 MAEL 17 TRIP13 16 CASP7 16 HLA-DPA1 16 MYLK-AS1 17 CAMTA1 17 MAGEAl0 17 TTYH3 16 CCDC117 16 HLA-DPB1 16 MYO7B 17 CBFA2T3 17 MAGEAl0- 17 TUBA3C 16 CCKBR 16 HSPB2- 16 NBR2 17 CCER1 MAGEA5 17TUSC5 16 CCSAP C11orf52 16 NEDD4L 17 CLEC17A 17 MAGEC2 17 UBE4B 16 CD58 16 IFITM2 16 NSUN4 17 COL9A1 17 MAP7D1 17 UGT1A1 16 CDK2AP1 16INTS12 16 NTM 17 CSNK1A1P1 17 MAT2A 17 UGT1A10 16 CECR1 16 ITFG3 16 NUDT9P1 17 CXorf6l 17 MBD3 17 UGT1A3 16 CERS1 16 ITIH5 16 OCA2 17 DCAF4 17 MGAT4C 17 UGT1A4 16 CGNL1 16 ITPKB 16 OPHN1 17 DLG2 17 MIR223 17 UGT1A5 16 CHD7 16ITSN2 16 OXCT1 17 DSCR4 17 MIR335 17 UGT1A6 16 CHMP3 16 KCNB2 16 OXR1 17 DSCR8 17 MIR378D2 17 UGT1A7 16 CLEC4C 16 KCNG2 16 PABPC3 17 EGFR 17 MYT1L 17 UGT1A8 16 COL22A1 16 KCNJ16 16 PABPN1 17 ELMSAN1 17 NDUFAl1 17 UGT1A9 16 CRYL1 16 KCNQ5 16 PAGE 17 EXOC2 17 NEURL1B 17 UNC5B 16 CT45A1 16 KDM5B 16 PARK2 17 FAM107B 17 NFYA 17 VPS51 16 CTNNA3 16 KDM5B-AS1 16 PAX8 17 FAM47A 17 NOBOX 17 WIPF1 16 CXorf36 16 KIAA2022 16 PCDH15 17 FAM58BP 17 NOS1AP 17 ZBTB7A 16 CYB5R2 16 KIF2B 16 PDE11A

16 PDHA2 16 TAF7 15 ANO9 15 CTBP2 15 GPR146 15 16 PER3 16 TAP2 15 APOA5 15 CTCFL 15 GPR25 LOC100507384 16PFKFB2 16TBCB 15ARHGAP22 15CTNNA2 15GPR75 15 16 PGGT1B 16 TCTEX1D4 15 ARHGEF18 15 CWC22 15 GPR75-ASB3 LOC100507584 16 PGK2 16 TDRD12 15 ARHGEF25 15 CYTH1 15 GPRC5C 15 16 PGPEP1L 16 TM7SF2 15 ARHGEF28 15 DCP1B 15 GPSM2 LOC100861402 16 PHLPP1 16 TMEM14C 15 ATF6 15 DENND1C 15 GRIN3B 15 LOC253039 16 PIK3R6 16 TMEM247 15 ATF6B 15 15 GRK5 15 LOC255025 16 PKHD1L1 16 TNFRSF1OA 15ATOH7 DKFZp566F0947 15 GSE1 15 LOC284100 16 PLA2G4E 16 TNFRSF1A 15 ATP2C1 15 15 GTSF1 15 LOC285441 16 PLEKHF1 16 TNFSF12- 15 ATP8A2 DKFZp68601327 15 HEXIM2 15 LOC285577 16 POM121L12 TNFSF13 15 B3GALT6 15 DLC1 15 HEY2 15 LOC407835 16 PPP1R2P9 16 TRIM27 15 BCL11A 15 DMRTC2 15 HLA-DPB2 15 LOC440356 16 PPP4R1L 16 TRIM36 15 BCL2L12 15 DNAJB3 15 HMG20B 15 LOC441601 16 PRKAR1B 16 TRPV2 15 BCL3 15 DND1 15 HMGN3 15 LOC646762 16 PROKR1 16 TRPV4 15 BFAR 15 DNMT3A 15 HNRPDL 15 LOC649395 16 PRR5 16 TSPAN32 15 BHLHB9 15 DOCK4 15 HPCAL1 15 LOC729176 16 PSD3 16 TSPY1 15 BHLHE40 15 DOK2 15 HSF2BP 15 LOC84856 16 PSMB5 16 TSPY4 15 BMS1P4 15 DOK7 15 ICAl 15 LPGAT1 16 PSORS1C2 16 TTC33 15 BOD1L2 15 DPP6 15 IL21R 15 LRP1B 16 PTAR1 16 TTC40 15 BST2 15 DPP9 15 IL21R-AS1 15 LTC4S 16 PTPLB 16 TUBA3D 15 BTBD11 15 DPPA5 15 IL22 15 LY6K 16 PTRF 16 TUBA3E 15 C10orf32 15 DYNC1H1 15 ING1 15 LYPD4 16 PVRL4 16 TYK2 15 Cl1orf53 15 DYNC1L12 15 INPP5D 15 MAGEA4 16 PXDNL 16 UBAP1L 15 C12orf5 15 DZIP1 15 INSL6 15 MAGEA8 16 RAB22A 16 UNC5D 15 C16orf90 15 E2F2 15 IQCAl 15 MAGEB10 16 RAB32 16 UPB1 15 C19orf25 15 EBPL 15 IRAK4 15 MAGIX 16 RAB5A 16 VASH1 15 C2 15 EEF1DP3 15 IRF3 15 MANBAL 16 RASGEFlC 16 VSIG2 15 C2orf27A 15 EEPD1 15 IRS2 15 MCM3AP 16 RBM11 16 WDR69 15 C3orf45 15 EGR1 15 ITGAX 15 MCM5 16 RBMS1 16 WDR88 15 C5orf47 15 EHD2 15 KCND2 15 MCMDC2 16 RCCD1 16 WLS 15 C5orf58 15 EHMT2 15 KCNG1 15 MCPH1 16 RFPL3-AS1 16 WSB1 15 C9orf170 15 EIF2AK4 15 KCNH8 15 METTL5 16 RIPK4 16 XKR4 15 CACNA2D1 15 ELAVL4 15 KCNK3 15 MGC72080 16 RNF166 16 YBX1 15CACNG2 15 ELK2AP 15 KCNT1 15 MGST1 16 RNF39 16 YOD1 15 CARD14 15 ENOPH1 15 KCTD15 15 MGST2 16 RP1 16 ZBTB17 15 CARHSP1 15 ERRF11 15 KDM2B 15 MIR3065 16 RPH3AL 16 ZBTB7C 15 CASZ1 15ESRRG 15 KHDC3L 15 MIR4785 16 RPL13 16 ZMIZ1 15 CAV1 15 FAM124A 15 KIAA0513 15 MIR548AP 16 RREB1 16 ZNF19 15 CCDC130 15 FAM160B2 15 KIDINS220 15 MIR548H4 16 RRP1B 16 ZNF282 15 CCDC141 15 FAM170B 15 KIF13B 15 MKRN2 16 RTN1 16 ZNF354B 15 CCDC162P 15 FAM20B 15 KIF3B 15 MLC1 16 RUFY1 16 ZNF611 15 CCDC173 15 FAM214A 15 KLF11 15 MOB3A 16 RYR1 16 ZNF784 15 CCDC71L 15 FAM217B 15 KLHDC7B 15 MOV10L1 16 SALL3 16 ZNF787 15 CCDC80 15 FAM221A 15 KLHL6 15 MPDU1 16 SARS 16 ZNF98 15 CCND3 15FANCF 15 KRAS 15 MPHOSPH6 16 SBF1P1 16 ZSCAN10 15 CCRL2 15 FGF17 15 KRT18P55 15 MPST 16 SBNO2 16 ZSWIM4 15 CCZ1B 15 FKBP5 15 L3MBTL1 15 MTSS1L 16 SDPR 16 ZYG11A 15 CDH11 15 FLI 15 LBX2 15 MX11 16 SH3BP5L 15 AATK 15 CDH23 15 FLJ42289 15LCOR 15 MYADML 16 SIVAl 15 ABCB6 15 CDH5 15 FLRT2 15LEMD2 15 MYEOV2 16 SLC22A18 15 ABT1 15 CDIPT 15 FMNL1 15 LIG1 15 MY015A 16 SLC25A21 15 ACER2 15 CDKL2 15FRMPD4 15 LIMCH1 15 MYO5C 16 SLC30A8 15 ACOT11 15 CDKN3 15 FTLP10 15 LINC00351 15 NAF1 16 SLC43A2 15ACRC 15 CDX1 15 GAB2 15 LINC00460 15 NCOR2 16 SLC44A2 15 ADAM18 15 CETN1 15 GABRB1 15 LINC00461 15 NDUFA13 16 SLC8A3 15ADAM8 15CHDH 15 GABRB3 15 15 NEILl 16 SLC9B2 15 ADAMTS12 15 CKLF-CMTM1 15 GAGE10 LOC100130581 15 NEURL3 16 SLCO5A1 15 AFF3 15 CLCN6 15 GAGE2E 15 15 NFATC2 16 SNURF 15 AGAP2 15 CLK2P 15 GAGE8 LOC100131094 15 NHSL2 16 SPG21 15 AGTR1 15 CLUAP1 15 GALNTL5 15 15 NICN1 16 SPRED2 15 AIPL1 15 CMTM1 15 GEMIN8P4 LOC100132831 15 NOSIP 16 SSBP2 15 AKAP10 15 CMTM6 15 GFM1 15 15 NOSTRIN 16 SSBP3 15AMT 15 CNTN1 15 GGT7 LOC100288198 15 NOTCH3 16 SSX3 15 ANKRD11 15 COL18A1 15 GJA8 15 15 NPAS1 16 SSX7 15 ANKRD2 15 COL9A2 15 GK2 LOC100294145 15 NR1D2 16 ST14 15 ANKRD33B 15 CSGALNACT1 15 GLUD1P3 15 15 NRXN1 16 STK11 15ANKRD9 15 CT45A6 15 GPATCH8 LOC100506733 15 NUBPL

15 OBEFCl 15 SAAL1 15 TMEM161A 14 AOVR1 B 140C3orf1 4 14OCYP4X1 15 ORlOQi 15 SAGE 15 TMEM72-AS1 14 AOYP2 14OC3orf3O 14OCYSTM1 15 OSBP2 15 SALL4 15 TNFSF1 3 14 ADAM1l1 140C3orf52 140DAB2 15 OSMR 15 SAP25 15 TNNT3 14A0AM2 140C3orf67 14 DACTi 15 OTU06A 15 SBK2 15TNP03 14 A0AMTS1 140C4orf36 140DA0T2 15 P2RX4 15S000AG8 15 TOMM20L 14 A0AMTS1 0 140C5orf56 140DBT 15 PAGE2 15 S0F4 15 TOR4A 14 A0AMTS1 7 14OC8orf4O 1400CAF8L1 15 PAR03B 15 SEC22A 15 TRAMi Ll 14 A0AMTSL1 140C8orf73 14 DDXi 15PARN 15 SEMA3B 15 TREXi 14 A00Y9 140C9orf43 1400DX4 15 PBX1 15 SEMA5A 15 TRIM2 14 ADHIE1l 140CA0NA204 140DDX43 15 PBX2 15 SEMA6A 15 TRIM29 14 AEBP1 14OCALB1 140DDX49 15 P00HA9 15 SH2B2 15 TRIM41 14 AEBP2 140CAMK10D 140DFFB 15 P0SK4 15 SH2B3 15 TRIM68 14 AFAP1 14OCANX 14 DGKZ 15 PEG10 15 SH2D4B 15 TRIM71 14 AGBL4 14OCAPINS1 14 DHX58 15 PEL11 15 SH3TO1 15TRPM2 14 AHDO1 14OCATSPER2 14 DIS32 15PGRMO1 15 SHANK2 15TRPM4 14AHRR 140CBX6 14 DLEU2 15 PHLDB3 15 SHMT1 15 TSPAN 17 14 AKAP 13 140000C142 14 DLGAP1 15 PHOSPH02 15 SIGIRR 15 TSSK6 14 ALDH5A1 140000C164 14 DLGAP1-AS3 15 PHOSPHO2- 15 SIPA1L3 15 TST 14 ALOX1 2 140000C166 14DM0 KLHL23 15 SLAIN2 15 TTC21 B 14 ALPK1 140000C73 14DMGDH 15 PINi Pi 15 SL01OA7 15TUBB8 14 ALS20L 1400CNB3 14 DNM1 L 15 PIWIL2 15 SL01 7A9 15TUBG0P2 14 ALS20R1 1 14CCNC 14 D0K6 15 PKN1 15 SL~lAl 15 UBR3 14 AMDHD2 1400CP1 10 14 DPPA2 15 PLEKHB1 15 SLC20A2 15 UBXN2B 14 AMMEORi L 1400CR6 14 DPPA3 15 PLEKHH1 15 SL022A1 8AS 15 UHRF1 BP1 L 14 AMPD3 1400D151 14 DUSKL 15 PNMA5 15 SL028A2 15 UNC13A 14 ANKRD26P1 1400D59 14 DYX1O1l 15 PODXL2 15 SLO2A5 15 UNC80 14 AN01O0 140CDH10 140DYX101l 15 PON2 15 SL03501 15 UNO93B1 14 AP3B2 1400DH6 OOPG1 15 POU51F2 15 SLO39A1O0 15 USP42 14 APBB2 14O0DHR5 14 EBAG9 15 PPFIA3 15 SLO6A1 6 15 USP49 14 ARHGAP1 2 1400DK1 8 14EDNRB 15PRNP 15 SNAPIN 15 VAMP3 14 ARHGAP30 1400DK6 14 EGFLAM 15 PRR23C 15 SNEDl 15 VHL 14 ARL1 3B 14OCELSR3 14 EIF4G1 15 PRSS3 15 SNORD58A 15VWDR60 14 ARL4O 140CEP1 04 14 ELAO1 15 PRSS35 15 SNORD58B 15 WNT7A 14 ART3 140CEP78 14 ELES 15 PRSS42 15 SNORD58C 15 WTAPP1 14 ATG9A 14OCEP85L 14 ELOVL7 15PSM0S 15 SNX20 15 XAGE3 14 ATP6VOO 14OCFH 14 ELT01 15 PSTPIP1 15 SOAT2 15 XIST 14 AUTS2 14OCHMP2B 14 EN2 15 PT0SS2 15 SOHLH1 15 YBEY 14 B3GNTL1 14OCHORDC1 14 EN04 15 PTPN6 15 SORBS2 15 ZA0H2 14 B4GALT7 14OCHSY3 14 EPHX4 15 PTPRE 15 SPATA16 15 ZBTB12 14 BAG2 14OCHURO1- 14 ERLIN2 15 PUS71L 15 SPONi 15 ZBTB47 14 BAIAP2 FNTB 14 ER01 L 15 PX0N 15 SSX1 15 ZFHX2 14 BASP1 14OCKLIF 14 ESRRB 15 RAB27A 15 ST20 15 ZFP57 14 BATEF 14OCLASIRP 14 EVPLL 15 RADIL 15 ST20-MTHFS 15 ZFPM1 14 BOLAF1 140CL0N7 14 EYA3 15 RALBP1 15 STK1O0 15 ZNF143 14 BHMT2 14OCLEO21L 14 F2RL3 15 RASGRF2 15 SUNi 15 ZNF217 14 BID 14OCLHO1 14 FAM163A 15 RB1 15 SUV42OH1 15 ZNF259 14 BMP2 14OCLMVN 14 FAM 171 A2 15 RBM24 15 SYOP2 15 ZNF264 14 BMP8A 14OCMAHP 14 FAM206A 15 RBM44 15 SYOP3 15 ZNF311 14 BNIPL 140CN0P2 14 FAM46D 15 RBM45 15 SYNJ2BP- 15 ZNF326 14 BOLA3 14OCNNM1 14 FAM50B 15 RBM46 C0X16 15 ZNF385A 14 BOLA3-AS1 14OCNP 14 FAM83B 15 RBM47 15SYNP02 15 ZNF438 14 BRIE 14 COPE 14 FAM96A 15 ROCl 15 TAF5 15 ZNF467 14 BRE-AS1 14CO01 B 14 FBXL1 9 15 RELLi 15 TAF8 15 ZNF599 14 BRSK1 14OCPAl 14 FBXL7 15 REX01 L2P 15 TB010Dl7 15 ZNF622 14OCll1orf2O 14OCPE 14FECH 15 RFES 1iTOPli1 15 ZNF665 140C1orf63 14OCPT1A 14FIER 15 RFPL4B 15T0R06 15 ZNF701 14OCl11orf8O 14OCRTAO1 14 FEZ1 15 RGS1 4 15TECR 15 ZNF831 14Ol12orfS6 14OCRYBG3 14 FIGLA 15 RIN3 15TENM2 15 ZNF853 140C15orf38 14OCRYZL1 14 FKBPL 15 RNU5F-1 15TENM3 15 ZNR01 -AS1 14Ol15orf38- 14OCSDE1 14 FKRP 15 ROB02 15 TEX1 4 15 ZPBP AP3S2 140CSM02 14FMN1 15 RPL1 7 15 TFAP4 15 ZSOAN5A 140C15orf43 14OCTPS1 14 FNTB 15 RPL1 7- 15 THBS4 14 AAED1 14Ol15orf6O 14OCTU1 14 FOLH1 01 80RF32 15 THTPA 14 ABOA1 14Cl orfll14 140CX0L9 14 FOPNL 15 RPS7 15 TLR6 14 ABOA13 14OClorfS6 14OCXXO1 14 FOXR1 15 RRP1 15TMO1 14 ABH01 6B 1401lorf87 140CYB561 14 FOXRE02 15 RYR2 15 TMEM 132D 14 AOSF3 140C2orf42 14OCYB5R3 14 FRAS1 15 SlO0GAl0 15 TMEM160 14 AOTLB 140C2orf61 140CYP2601 14 FRM04A

14 FRMD8 14 KANK2 14 LOC644649 14 NPFFR2 14 PRR20D 14 SLC25A16 14 FSTL1 14 KAT6B 14 LOC650226 14 NPHP3 14 PRR20E 14 SLC25A22 14 FTCD 14 KAZN 14 LOC728613 14 NPHP3- 14 PRR5- 14 SLC25A45 14FUNDC2P2 14KBTBD5 14LOXHD1 ACAD11 ARHGAP8 14SLC25A48 14 FUT4 14 KCNC2 14 LOXL1 14 NPHP3-AS1 14 PRRC2A 14 SLC25A51P1 14 FZD5 14 KCND3 14 LPAR5 14 NPR2 14 PRSS22 14 SLC34A2 14 GAB1 14 KCNK4 14 LPCAT2 14 NPTN 14 PRSS50 14 SLC35C1 14 GAB4 14 KCNMAl 14LRCH4 14 NR3C1 14 PRSS55 14 SLC37A4 14 GAGE2A 14 KCNV2 14LRRC4 14 NRG1 14 PSMA8 14 SLC6A6 14 GATM 14 KCTD12 14 LRRC56 14 NSA2 14 PTPN21 14 SLC6A8 14 GDE1 14 KDM5C 14 LRRK1 14 NUP133 14PURG 14 SLC9A4 14 GDF10 14 KIAA0664 14LSM6 14 NUS1 14 PUS10 14 SMAD3 14 GEMIN8 14 KIAA1211L 14 LY86-AS1 14 NXT2 14PYROXD2 14 SMARCA2 14 GFM2 14 KIAA1383 14 MACROD2 14 OOEP 14 R3HDM4 14 SMARCA5 14 GFPT1 14 KIAA1522 14 MAFK 14 OPRK1 14 RABL6 14 SMCR7 14 GFRA3 14 KIAA1875 14 MAGEB18 14 ORA13 14 RAP1GAP2 14 SMG6 14 GINS4 14 KIAA1984 14 MAML1 14 OSBPL7 14 RARA 14 SMOC2 14 GLB1L2 14 KIAA1984-AS1 14 MANlCl 14 OTX1 14 RARB 14 SMTNL2 14 GLOD4 14 KLF15 14 MAP2K3 14 P2RY1 14 RASA3 14 SNAR-I 14 GLRX2 14 KLF17 14 MBP 14 PACSIN1 14 RASAL3 14 SND1 14 GLT25D1 14 KLHDC7A 14 MBTPS2 14 PAG1 14 RBKS 14 SNTG1 14 GNAL 14 KRBOX1 14 METTL16 14 PAGE3 14 RBM15B 14 SNX1 14 GNG13 14 KRT85 14 MEX3B 14 PAOX 14 RBM33 14 SNX8 14 GPLD1 14 KRTAP19-5 14 MGC2752 14 PAQR9 14 RDH11 14 SOCS5 14 GPR158 14 KT112 14 MIA3 14 PCBD1 14 RDH14 14 SPESP1 14 GPR45 14 L3MBTL3 14 MIMT1 14 PCDHA10 14 RGPD3 14 SPN 14 GPR97 14 LAMA4 14 MIR130B 14 PCDHA11 14 RGS10 14 SPTB 14 GREM2 14 LAT2 14 MIR23A 14 PCDHA12 14 RGS12 14 SPTBN5 14 GRHL2 14 LCK 14 MIR24-2 14 PCDHA13 14 RHOBTB1 14 SREBF1 14 GUCY2D 14 LDB3 14 MIR27A 14 PCDHB8 14 RIN2 14SRGN 14 GUCY2GP 14 LDHAL6A 14 MIR301B 14 PCGF3 14 RIT2 14SRRM2 14 GUSBP11 14 LEPRELl 14 MIR3136 14 PCSK1N 14 RLN1 14 SRRM2-AS1 14 H1FNT 14LHPP 14 MIR320E 14 PCSK2 14 RNF17 14 SSX21P 14 HAS1 14 LINC00242 14 MIR4426 14 PDE9A 14 RNF2 14 ST6GALNAC3 14 HCN1 14 LINCO0301 14 MIR4795 14 PDZD7 14 RNMTL1 14 STAB1 14 HEATR2 14 LINC00379 14 MIR548W 14 PEG3 14 RNPEP 14 STARD8 14 HEXDC 14 LINC00574 14 MLLT1 14PEMT 14 RPA4 14 STEAP3 14 HIBADH 14 LINC00588 14 MMADHC 14 PFN3 14 RPL31 14 STK32A 14 HIVEP2 14 LINCO0640 14 MMP13 14PGAM2 14 RPL6 14 STRA8 14 HLA-F 14 14 MMP9 14 PHF19 14 RPS27A 14 SYCE1L 14 HLA-G LOC100129138 14 MNS1 14 PICK1 14 RPS4X 14 SYNJ2BP 14 HLA-J 14 14 MOB3C 14 PION 14 RRP15 14 SYTL1 14 HLA-L LOC100131089 14 MON1B 14 PITPNM1 14 RUNX1 14 TAG 14 HLCS 14 14 MORC2 14 PLA2G16 14 RXRA 14TAGAP 14 HMHA1 LOC100131496 14 MRC2 14 PLCB2 14 S100Z 14 TCEAL4 14 HOOK2 14 14 MRGPRE 14 PLD1 14 S1PR4 14 TCEAL6 14 HOXA2 LOC100287704 14 MRPL53 14 PLEKHG5 14 SCRN2 14 TEF 14 HRAS 14 14 MRPS14 14 PLEKHG6 14 SCT 14 TES 141CAlL LOC100289187 14 MRPS17 14 PLEKHH3 14 SCUBE3 14 TEX101 141DS 14 14 MRPS9 14 PNPLA6 14 SEL1L2 14 TEX264 14IDUA LOC100289673 14 MSGN1 14 POLE3 14 SEMA5B 14 TEX30 14IGLL1 14 14 MTHFR 14 POLE4 14 SEPT 14 TFPT 14 IGSF11 LOC100506122 14 MTMR3 14 POLG 14 SEPT9 14 TGIF2LY 14IKBKAP 14 14 MYO16 14 PPAP2C 14 SERPINE1 14 THSD7A 14 IL16 LOC100506994 14 MYO1H 14 PPP1R16B 14 SETBP1 14 TIALl 14 IL6 14 14 NAGLU 14 PPP3CC 14 SFRP2 14 TIPIN 14INPP5B LOC100507377 14 NAPEPLD 14PRDM1 14 SFXN3 14 TKTL2 14INTS2 14 LOC145663 14 NAV1 14 PRDM10 14 SH3BP5 14 TLL2 14IQCE 14 LOC148696 14 NECAB1 14PRDM2 14 SH3GL3 14 TMEM132C 14 IQCG 14 LOC150568 14 NEK3 14 PRKAG2 14 SH3PXD2A 14 TMEM140 14IQSEC3 14 LOC154822 14 NFATC4 14 PRKCZ 14 SHANK3 14 TMEM151A 14IRAK2 14 LOC283692 14 NHP2 14 PRKD2 14SHROOM3 14 TMEM229B 14 IRGQ 14 LOC284023 14 NHSL1 14 PRMT8 14 SIAH3 14 TMEM242 14IRS1 14 LOC284454 14 NID1 14 PRPF31 14 SIM1 14 TMEM26 14 ITGB2 14 LOC284798 14 NINJ2 14 PRR12 14 SIPAl 14 TMF1 14 ITGB2-AS1 14 LOC285501 14 NKX6-3 14 PRR20A 14 SLCl5Al 14 TNFAIP8 14 ITSN1 14 LOC285972 14 NMUR2 14 PRR20B 14 SLC16A14 14TOX 14 JPH3 14 LOC339894 14 NOX5 14 PRR20C 14 SLC22A31 14 TPCN1

14 TPD52L2 14 ZNF746 13 BCAR3 13 CIT 13 EXOC6B 13 HBQ1 14 TRAF31P2 14 ZNF766 13 BCMO1 13 CLCA4 13 EXOSC3 13 HIBCH 14 TRAF31P2-AS1 14 ZNF777 13 BMP1 13 CLDN18 13 EZH1 13 HIST1H2AA 14 TRIM61 14 ZNF837 13 BOK-AS1 13 CLIC6 13 FA2H 13 HIST1H2BA 14 TRIM62 14 ZNF839 13 BRCA2 13 CLN3 13 FAM109B 13 HIST1H3E 14 TRIML1 14 ZNRD1 13 BRF1 13 CLTB 13 FAM111A 13 HIST3H3 14 TRPS1 14 ZRANB2 13 BR13 13 COASY 13 FAM122C 13 HIVEP3 14 TSKS 14 ZRANB2-AS2 13 BTK 13 COL5Al 13 FAM125B 13 HMGCL 14 TSNAX 13 A1BG 13 C10orf128 13 COL6A4P2 13 FAM170A 13 HMGCLL1 14 TSNAX-DISC1 13 ABHD12 13 C15orf62 13 COL6A6 13 FAM174B 13 HMOX2 14 TSPAN31 13 ABHD14A 13 C15orf63 13 COX6A2 13 FAM188A 13 HNRNPC 14 TSPYL2 13 ABHD14A- 13 C17orf28 13 COX7B2 13 FAM24B 13 HOMER3 14 TSPYL5 ACY1 13 C17orf6l 13 CPEB1 13 FAM24B- 13 HOXC4 14 TTC22 13 ABHD14B 13 C17orf61- 13 CPLX1 CUZD1 13 HPS4 14TTTY23 13ACAP3 PLSCR3 13CPN1 13FAM83A 13 HSH2D 14 TTTY23B 13 ACBD3 13 C17orf64 13 CR1L 13 FAM83H 13 HYAL2 14 TUG1 13 ACER3 13 C19orf35 13 CRBN 13 FBF1 13 ID02 14 TXNDC12 13 ACTRT3 13 C19orf66 13 CRH 13 FBLN7 13 IFITM5 14 UNC13B 13ADAM5 13 C1orf65 13 CRTAM 13 FBN1 13 IFNAR2 14 USP29 13 ADCY3 13 C20orfl5l 13 CSF2 13 FBN2 13 IGDCC3 14 USP43 13 ADCY5 13 C20orf96 13 CSGALNACT2 13 FBRSL1 13 IGSF3 14 UTP11L 13ADCY8 13 C22orf28 13 CSNK1A1L 13 FBXW8 13 IL12B 14 VAT1L 13 ADRA1D 13 C2CD2L 13 CTAG2 13 FCER1G 13 L17D 14 VCL 13 ADRA2C 13 C2orf74 13 CTAGE7P 13 FFAR1 13 IL1RAPL2 14 VCX3B 13 ADSS 13 C5orf42 13 CUX2 13 FGFR1 13 INCENP 14 VENTXP7 13 AGER 13 C5orf52 13 CXCL1 13 FHIT 13 INSR 14 VGLL4 13 AGMO 13 C5orf63 13 CYFIP2 13 FHL2 13 INTS1 14 VPREB1 13 AHNAK2 13 C6orf25 13 CYP2E1 13 FITM2 13 IQSEC1 14 VPS13B 13 AIP 13 C7orfl3 13 CYR61 13 FLJ25363 13 IRF5 14 VWA1 13 AKIP1 13 C7orf45 13 CYTH4 13 FLJ46906 13 ISM1 14 VWA7 13 AKR1B1 13 C8orf86 13 DCC 13 FLNA 13 ITGA4 14 WDR13 13 ALDH3B1 13 C9orf47 13 DCLK1 13FNDC5 13 ITPKA 14 WDR43 13 ALOXE3 13 CABLES2 13 DCUN1D1 13 FOXC2 13 ITPRIPL2 14 WFIKKN1 13 ALPK3 13 CACNA1S 13 DDAH1 13 FOXK1 13 JAK2 14 WNT5B 13 AMIGO2 13 CACNB1 13 DHRS7C 13 FOXN2 13 JAKMIP1 14 WRN 13 AMMECR1 13CACNG6 13 DHX35 13 FRMD6-AS2 13JRKL 14 YPEL4 13 ANKRD13B 13 CACTIN-AS1 13 DLK1 13 FUT6 13 KCNA1 14 ZBTB2 13 13CADM4 13 DNAH8 13 FXN 13 KCNE4 14 ZBTB20 ANKRD20A11P 13 CALML3 13 DNAH9 13 FZD1 13 KCNIP2 14ZBTB7B 13ANKRD30BL 13CALML5 13DNA12 13GABARAPL3 13KCNQ1DN 14 ZC3H8 13AN08 13 CAMTA2 13 DNAJB6 13 GAL 13 KCNT2 14 ZC3HC1 13APOB 13 CAPZB 13 DNAJC17 13 GAL3ST1 13 KIAA0226 14 ZDHHC14 13APOBR 13 CASP5 13 DNAJC27 13 GEMIN5 13 KIAA0319L 14 ZEB2 13APOOL 13 CCDC102B 13 DNAJC27-AS1 13 GFOD1 13 KIAA0391 14 ZFYVE28 13 AQP11 13 CCDC116 13 DNAJC5G 13 GFPT2 13 KIAA0528 14 ZIM2 13 ARHGEF19 13 CCDC152 13 DNASE1L1 13 GJA9 13 KIAA1549 14ZMYND8 13ARMC9 13 CCDC17 13 DOCK10 13 GJA9-MYCBP 13 KIF23 14 ZNF18 13ARMCX1 13 CCDC25 13 DOK3 13 GJD3 13 KIF3C 14 ZNF232 13 ARPC2 13 CCDC82 13 DPY19L2P3 13 GLO1 13 KIRREL3 14 ZNF236 13ARSD 13 CCDC85A 13 DRD4 13 GNPDA1 13 KLF14 14 ZNF267 13 ARVCF 13 CCDC90B 13 E2F7 13 GPC2 13 KLHDC1 14 ZNF275 13 ASB4 13 CCDC96 13 EBF3 13 GPR111 13 KLHDC5 14 ZNF286A 13 ASCL2 13 CCNB1 13 EFHA1 13 GPR12 13 KLHL17 14 ZNF330 13ASGR1 13 CCZ1 13 EHBP1Li 13 GPR133 13 KLHL22 14 ZNF341 13ASPDH 13 CD177 13 EHMT1 13 GPR135 13 KLHL36 14 ZNF350 13ASPH 13 CD1D 13 ELFN1 13 GPR143 13 KLK4 14 ZNF428 13 ASPHD1 13 CD47 13 ELK4 13 GPR160 13 KRT83 14 ZNF48 13 ATF71P2 13 CDH24 13 ELOVL2 13 GPR20 13 LAMC2 14 ZNF517 13 ATG5 13 CDK12 13 ELOVL2-AS1 13 GPR4 13 LBX2-AS1 14 ZNF556 13 ATP6VOCP3 13 CDKN1A 13EMD 13 GPR89B 13LDLRAD2 14 ZNF576 13 ATP6VOD1 13 CELF6 13 EMP1 13 GPRIN1 13LHCGR 14 ZNF598 13 ATP7A 13 CENPJ 13 EP400NL 13 GPRIN2 13 LHFPL5 14 ZNF643 13 AURKAIP1 13 CENPM 13 EPHA1-AS1 13 GRK7 13 LIMK1 14 ZNF679 13 AXIN2 13 CERS3 13 ERC2 13 GRTP1 13 LINC00167 14 ZNF688 13 B3GNT6 13 CGREF1 13ERG 13 GSDMD 13 LINCO0310 14 ZNF689 13 B4GALNT3 13 CHCHD6 13 ESCO2 13 GTF21RD1 13 LINC00332 14 ZNF697 13 BAIAP2L2 13 CHST6 13 ETV6 13 GTPBP3 13 LINC00634 14 ZNF718 13 BCAR1 13 CIITA 13 EVPL 13 H2BFM 13 LIPK

13 13 MEX3D 13 NLRP4 13 PRAM1 13 SHISA2 13 TAZ LOC100129636 13 MFI2 13 NME8 13 PRICKLE3 13 SIGLEC15 13 TBC1D10C 13 13 MFSD2B 13 NMRAL1 13 PRKACA 13 SIM2 13 TBC1D7 LOC100129931 13 MGAT3 13 NOC2L 13 PRKCA 13 SLC16A8 13 TBPL2 13 13 MGC3771 13 NOVA2 13 PRKCH 13 SLC16A9 13 TCEAL2 LOC100131691 13 MGMT 13 NPAP1 13 PRSS36 13 SLC22A3 13 TCEAL3 13 13 MICAL2 13 NR1H3 13 PRSS41 13 SLC23A2 13 TCN2 LOC100131726 13 MIR100HG 13 NR6A1 13 PSD 13 SLC25A14 13 TDRG1 13 13 MIR1225 13 NRBF2 13 PSMB9 13 SLC25A29 13 TERC LOC100144597 13 MIR1256 13 NRXN3 13 PSORS1C3 13 SLC25A31 13 TEX13A 13 13 MIR125B1 13 NT5DC1 13 PTK6 13 SLC25A33 13 TEX13B LOC100499194 13 MIR141 13 NUP21OL 13 PTPRU 13 SLC25A3P1 13 TFDP2 13 13 MIR153-2 13 NXPH2 13 PVWVP2B 13 SLC26A1 13 TFEB LOC100506082 13 MIR181A2HG 13 NYAP2 13 QPCT 13 SLC26A8 13 TFF2 13 13 MIR195 13 OASL 13 RAB13 13 SLC37A1 13 THRB LOC100507547 13 MIR196A1 13 ODC1 13 RAB3D 13 SLC41A1 13 TIE1 13 13 MIR200C 13 ODF2 13 RAB40B 13 SLC47A2 13 TIGD3 LOC100507605 13 MIR32OB1 13 OPCML 13 RAC1 13 SLC5A3 13 TMC8 13 13 MIR3684 13 ORA11 13 RAD51C 13 SLC7A5 13 TMEM151B LOC100996291 13 MIR371B 13 OSBPL5 13 RANBP17 13 SLCO3A1 13 TMEM173 13 LOC284998 13 MIR372 13 OSBPL6 13 RAP1A 13 SLMO2 13 TMEM175 13 LOC285626 13 MIR373 13 OSCAR 13 RAPGEF1 13 SLMO2-ATP5E 13 TMEM209 13 LOC286467 13 MIR4750 13 OSM 13 RASGEF1B 13 SMARCALl 13 TMPRSS9 13 LOC339529 13 MIR497 13 OTOP2 13 RASL11B 13 SMC1B 13 TMX3 13 LOC339803 13 MIR497HG 13 P2RX7 13 RAVER2 13 SNAR-H 13 TNFAIP8L2 13 LOC349160 13 MIR550A3 13 PACS2 13 RBM25 13 SNORA14B SCNM1 13 LOC387723 13 MIR5584 13 PAGE4 13 RBM6 13 SNORA38 13 TNFRSF1B 13 LOC399815 13 MIR589 13 PAPOLB 13 RBP4 13 SNORA80B 13 TNFRSF25 13 LOC400043 13 MLX 13 PARD3 13 RFC1 13 SNX16 13 TNK1 13 LOC440900 13 MPC1L 13 PARP4 13 RGAG1 13 SNX25 13 TOMM20 13 LOC493754 13 MRPL19 13 PART1 13 RHBDF1 13 SNX29 13 TPI1P2 13 LOC63930 13 MRPL22 13 PASD1 13 RHOXF1 13 SNX4 13 TPM1 13 LOC644990 13 MRPL39 13 PBK 13 RIBC2 13 SOX10 13 TPTE2P5 13 LOC653486 13 MRPS22 13 PCDHB16 13 RNF175 13 SPAG7 13 TRIM38 13 LOC728012 13 MRPS6 13 PCDHB17 13 RNF32 13 SPARCL1 13 TRIM43 13 LOC728743 13 MSH4 13 PCDHB18 13 RNF44 13 SPECC1 13 TRIM60 13 LPIN1 13 MSRA 13 PCDHB6 13 ROBO1 13 SP11 13 TRIM65 13LPPR3 13 MSTO2P 13 PCSK6 13 RORA 13 SPSB4 13 TRIM7 13 LRP5 13 MTSS1 13 PDE1A 13 RPL13AP3 13 SPTBN4 13 TRMT61A 13 LRRC4B 13 MXRA7 13 PDE4D 13 RPRM 13 SRD5A1P1 13TRPC3 13 LRRC66 13 MXRA8 13 PDLIM7 13 RPS27 13 SRRD 13 TSC22D1 13 LRRC72 13 MYCBP 13 PDXDC2P 13 RPUSD3 13 SRSF5 13 TSC22D1-AS1 13 LRRIQ4 13 MYEF2 13 PDXK 13 RSPH1 13 SSX5 13 TSC22D4 13LRRN4CL 13 MYNN 13 PEBP4 13 RTEL1 13 ST5 13 TSPAN16 13 LSP1P3 13 MYO10 13 PES1 13 RTEL1- 13 ST6GALNAC6 13 TSPY2 13 LTBP4 13 MYO18A 13 PlH1D1 TNFRSF6B 13 ST8SIA5 13 TSPYL6 13 LUC7L 13 MYO18B 13 PIK3CG 13 S100B 13 STAG3 13 TTC39B 13 LY6G6C 13 MYO9B 13 PIM1 13 S1PR1 13 STARD13 13 TTLL13 13 LYSMD1 13 MZF1 13 PITRM1 13 S1PR3 13 STARD3NL 13 TUBA8 13 MAGED2 13 N4BP1 13 PKD1 13 SATL1 13 STK32C 13TYROBP 13 MAGEE1 13 NAA11 13 PKP1 13 SCARA5 13 STON1- 13 UBE2K 13 MAGEL2 13NAGA 13 PLCD3 13 SCGB1C1 GTF2A1L 13 UBE2Z 13 MAK16 13 NAPSB 13 PLCL2 13SCNM1 13 STOX1 13 UBXN4 13 MALL 13 NCAM1 13 PLEKHA2 13 SEC14L4 13 STX16- 13 UHMK1 13 MAML3 13 NCF4 13 PLIN5 13 SEL1L3 NPEPL1 13 UNC13D 13 MAP3K6 13 NDNF 13PNCK 13 SELM 13 SUGT1P3 13 USB1 13 MAPK14 13 NDUFA12 13 POLE2 13 SELT 13SUM03 13 USF2 13 MARK4 13 NDUFS2 13 POLR2G 13 SEMA3G 13 SYCE1 13 USH1G 13 MARS 13 NEIL2 13 POLRMT 13 SENP5 13 SYDE1 13 USP18 13 MARVELD1 13 NEU1 13 POM121L9P 13 SERF2- 13 SYN1 13 USP53 13 MAST4 13 NFATC1 13 PON3 C150RF63 13 SYNE2 13 USP7 13 MBTPS1 13 NFYB 13 POTEA 13 SERHL2 13 SYS1 13 UTS2D 13 MCHR2 13 NIPA1 13 PP2D1 13 SERINC4 13 SYS1-DBNDD2 13 UXS1 13 MCOLN1 13 NIPSNAP3B 13 PPIE 13 SEZ6L2 13 SYT2 13 VENTXP1 13 MDGA1 13 NKAIN4 13 PPM1H 13 SH3GL1 13 TADA2B 13 VIPR1 13 MEGF10 13 NLGN2 13 PPP1R13L 13 SH3RF3 13 TAF3 13 VPS37B 13 MERTK 13 NLRP11 13 PPP1R2P3 13 SH3RF3-AS1 13 TAF4 13 VWA5B2 13 METAP1 13 NLRP2 13 PPP2R3C 13 SHANK1 13 TAP1 13 VWF

13 WARS2 12 ANKRD24 12 CAD 12 CUTC 12FCHO2 12 HTR7P1 13 WDR24 12 ANKRD31 12 CAMSAP3 12 CWF19L1 12 FCN3 12 IBA57 13 WDR35 12 ANKRD7 12 CAPG 12 CYP21A1P 12FERMT3 12 ICAM3 13 WHSC2 12 AP2A1 12 CARD9 12 CYP21A2 12 FGF11 12 IFFO1 13 WIF1 12 APBA2 12 CARS2 12 CYP2J2 12FHOD1 12 IFT140 13 WIZ 12 APLNR 12 CBR4 12 DAZAP2 12 FKBP9 12 IKZF4 13 WRAP73 12APOE 12 CBX4 12 DCTN2 12 FLJ42627 12 IL411 13 WWC2 12 APTX 12 CCBP2 12 DCTN4 12 FNDC1 12 ILDR1 13 XAF1 12 ARAP1 12 CCDC104 12 DDX11 12 FNIP1 121MP4 13 XYLT1 12 ARHGAP25 12 CCDC115 12 DDX11-AS1 12 FOXO3B 12IRF2BPL 13 YDJC 12 ARHGAP39 12 CCDC177 12 DENND2D 12 G3BP2 12 ITGA1 13 YJEFN3 12 ARL2BP 12 CCDC27 12 DGKD 12 GABBR1 12 ITGA6 13 ZAR1L 12 ASAP3 12 CCDC74B-AS1 12 DIABLO 12 GABRA5 12 ITGA7 13 ZBTB16 12 ASCL5 12 CCDC88B 12 DIEXF 12 GADL1 12 ITGAL 13 ZBTB20-AS1 12 ASIC1 12 CCN12 12 DLG4 12 GAGE12B 12 ITIH1 13 ZC3H12A 12 ATF71P 12 CCNL1 12 DNAJB1 12 GAGE12C 121TM2C 13ZCCHC3 12 ATG7 12 CCT6A 12 DNAJC13 12 GAGE12D 12 KAZALD1 13 ZFPM2 12 ATP2A3 12 CD300LF 12 DNAJC15 12 GAGE12E 12 KBTBD8 13 ZFYVE26 12 ATP6AP1L 12 CD79B 12 DNLZ 12 GAGE12F 12 KCNJ15 13 ZNF136 12 ATP6V1C1 12 CDA 12 DOCK9 12 GAGE12G 12 KCNQ4 13 ZNF205 12 ATPBD4 12 CDC37 12DOHH 12 GAGE12H 12 KCNUl 13 ZNF212 12 ATPBD4-AS1 12 CDC5L 12 DPEP3 12 GAGE121 12 KCTD5 13 ZNF229 12 ATRAID 12 CDHR1 12 DPM1 12 GAGE2C 12 KCTD6 13 ZNF235 12 ATXN1 12 CDKN2C 12 DRAP1 12 GAGE2D 12 KDM6A 13 ZNF280A 12 ATXN3 12 CDR2 12 DSCAM 12 GAGE4 12 KIAA1614 13 ZNF280D 12 ATXN7L1 12 CDR2L 12 DSEL 12 GAGE5 12 KIAA1731 13 ZNF319 12 ATXN8OS 12 CENPF 12 DTX1 12 GAGE7 12 KIF5A 13 ZNF358 12AURKC 12 CENPW 12 DUOX1 12 GALC 12 KIF5B 13 ZNF396 12 B4GALNT4 12 CEP120 12 DUS4L 12 GALE 12 KLF6 13 ZNF423 12 BA12 12 CERK 12 DUSP2 12 GAN 12 KLHL1 13 ZNF444 12 BAIAP2-AS1 12 CERS2 12 DYM 12 GCK 12 KREMEN2 13 ZNF497 12 BCL11B 12 CFDP1 12 EBF1 12 GCSAML-AS1 12 KRTAP17-1 13 ZNF524 12 BEND4 12 CFP 12 EBNA1BP2 12 GDF9 12 LAGE3 13 ZNF625 12 BLOC1S1 12 CHAF1B 12 ECE1 12 GHRLOS 12LAPTM5 13 ZNF625-ZNF20 12 BLOC1lS- 12 CHCHD4 12 EIF3M 12 GJA3 12 LDLRAP1 13 ZNF629 RDH5 12 CHMP6 12 ELF2 12 GJA5 12 LGALS12 13 ZNF644 12 BNIP2 12 CHODL 12 ELF4 12 GLUL 12 LGALS9 13 ZNF645 12 BNIP3 12 CHRNB3 12 ELL 12 GNA14 12 LILRB1 13 ZNF648 12BOK 12 CHST11 12 EMILIN1 12 GNB4 12 LIMS2 13 ZNF682 12 BOLA1 12 CHST12 12 EML2 12 GPR112 12 LINC00029 13 ZNF764 12 BRAF 12 CHST15 12 ENSA 12 GPR132 12 LINC00032 13 ZNF768 12 BTBD2 12 CHST8 12 EPB49 12 GPR6 12 LINC00200 13 ZNF77 12 BTBD6 12 CILP2 12 EPHA3 12 GPR68 12 LINC00426 13 ZNF774 12 BVES 12 CLCC1 12 EPHB3 12 GPSM3 12 LINC00535 13 ZNF782 12 BVES-AS1 12 CLCF1 12 ESD 12 GSN 12 LINC00643 13 ZNF785 12 BZRAP1 12 CLP1 12 EXOC8 12 GSPT2 12LMO2 13 ZNF786 12 BZRAP1-AS1 12 CLSTN2 12 F10 12 GTDC1 12 13 ZNF835 12 C10orf118 12 CMIP 12 FAM100A 12 GYS1 LOC100128993 13 ZNF84 12 C11orf68 12 CNTD1 12 FAM110B 12 HAPLN4 12 13 ZNHIT3 12 C12orf75 12 CNTNAP1 12 FAM115A 12 HCG4B LOC100129520 12 ABCC1 12 C14orf162 12 COA3 12 FAM165B 12 HCN3 12 12 ACAP1 12 C14orf28 12 COG5 12 FAM178B 12 HEATR7A LOC100130015 12 ACTN2 12 C16orf70 12 COL16A1 12 FAM207A 12 HEBP1 12 12 ADAM19 12 C17orf101 12 COL2A1 12 FAM3A 12 HELZ2 LOC100130987 12 ADAM30 12 C17orf49 12 COL4A1 12 FAM46C 12 HERC2 12 12 ADNP2 12 C17orf97 12 COL4A2 12 FAM47C 12 HHIPL1 LOC100293534 12 ADORAl 12 C18orf34 12 COL9A3 12 FAM53B 12 HIVEP1 12 12 ADORA3 12 C1QL3 12 COX15 12 FAM57B 12 HLA-DRB1 LOC100505806 12 AFF1 12 Clorfl06 12 CPLX2 12 FAM98C 12 HMHB1 12 12 AFMID 12 Clorfl45 12 CPNE4 12 FAM9C 12 HNF4A LOC100507424 12 AGBL5 12 Clorf204 12 CPPED1 12FANCC 12 HOXA-AS3 12 LOC282980 12 AGFG1 12 C21orf9l 12 CRISP2 12 FANK1 12 HOXA5 12 LOC283050 12AGRN 12 C2orfl6 12CROCC 12 FASTKD5 12 HOXB6 12 LOC284661 12 AICDA 12 C4A 12 CSN1S2BP 12 FAT1 12 HOXB7 12 LOC284688 12 AIF1 12 C4B 12 CSNK1Gl 12 FBXL16 12 HOXC-AS5 12 LOC400680 12 AIFM1 12 C4orf47 12 CSNK2Al 12 FBXO21 12 HOXC13 12 LOC400940 12 AKR1E2 12 C8orf44-SGK3 12 CTU2 12 FBXO46 12 HS6ST1 12 LOC619207 12 ALOX5 12 C9orfl23 12 CUL4B 12FCAMR 12 HSPA1B 12 LOC643037

12 LOC643542 12 NFIX 12 PRR25 12 SMIM1 12 UBQLN1 11 ALDH1Ll 12 LOC728431 12 NGDN 12 PRSS21 12 SMURF1 12 UBXN1 11 ALDH4A1 12 LOC729080 12 NGFR 12 PSMB7 12 SNF8 12 UCHL1 11 ANG 12 LOC730101 12 NGLY1 12 PSMD6 12 SNORA37 12 UCK2 11 ANGPT2 12 LOC731275 12 NIPAL2 12 PSRC1 12 SNORD123 12 UCKL1 11 ANKAR 12 LONRF1 12 NR5A1 12 PTBP1 12 SNRPD1 12 UFSP2 11 ANKRD13D 12 LOXL1-AS1 12 NRG3 12 PTHLH 12 SNX18 12 UGT8 11 ANKRD45 12 LRFN2 12 NRIP2 12 PTK7 12 SOGA3 12 UHRF1 11 ANO4 12 LRP12 12 NT5C 12 PTPN23 12 SPACAl 12 UNC5A 11 ANP32B 12 LRP8 12 NTRK3 12 PTPRA 12 SPATA13 12 UNC5C 11 AP2A2 12 LRRC34 12 NTSR2 12 PUF60 12 SPATC1 12UQCRQ 11 AP2B1 12 LSP1 12 NXN 12 PVT1 12 SPHK2 12 USP12 11 AP4S1 12 LTBP3 12 OBSCN 12 PXMP2 12 SPRTN 12 USP13 11 APCDD1 12 LYNX1 12 OLA1 12 QRFP 12SRRM4 12 USP2 11 APOBEC3A_B 12 MACROD1 12 OR2C3 12 QRFPR 12 SSTR1 12 USP35 11 AQP9 12 MAFF 12 OXSM 12 RAB15 12 STEAP2 12 USP45 11 ARHGEF33 12 MAGEA1 12 PAGE 12 RAB33A 12 STYX 12 UTY 11 ARL2 12 MAGEB16 12 PALD1 12 RAB37 12 SUMF2 12 VDAC3 11 ARL2-SNX15 12 MAG12 12 PALLD 12 RAB3C 12 SV2B 12 VPS13D 11 ARPP21 12 MAG12-AS3 12 PANK3 12 RAB40AL 12 SYNGAP1 12 VRK2 11 ASAP1 12 MAMDC2 12 PAQR4 12 RAD51L3- 12 SYNJ2 12 VSIG8 11 ASB8 12 MAP1B 12 PARVG RFFL 12 TARSL2 12 VT11A 11 ASNAl 12 MAP1LC3A 12 PATL1 12 RAD52 12 TBCD 12 WDR65 11ASPSCR1 12 MAP3K11 12 PCDHB19P 12 RAE1 12 TBX6 12 WNT1OB 11 ATMIN 12 MAP7 12 PDE7B 12 RAN 12 TDRD1 12 WTIP 11 ATP5D 12 MARKS 12 PDE8B 12 RAP2A 12TENM4 12 VWVC2-AS2 11 ATP8B4 12 MATN4 12 PELO 12 RASGRP2 12 TERT 12 XP04 11 ATRIP 12 MBD2 12 PEX19 12 RBFOX3 12 TEX22 12 XPOT 11 AVPR1B 12 MC1R 12 PFKFB3 12 RBM20 12 TGFBR1 12 XRCC5 11 B3GNT8 12 MCHR1 12 PGLYRP2 12 RBP7 12 TGIF2LX 12 YLPM1 11 BCCIP 12 MED1 12 PHACTR1 12 RBPJ 12THEM4 12 YPEL3 11 BCDIN3D 12 MED15 12 PHAX 12 RDH5 12 TIMM8A 12 ZC3H3 11 BCKDK 12 ME11 12 PHF14 12 RECQL5 12 TK1 12 ZCCHC13 11 BCL2L11 12 MELK 12 PHF16 12 REM2 12 TLR5 12 ZCCHC14 11 BDKRB1 12 METTL22 12 PHF23 12 RFFL 12 TMC6 12 ZFP92 11 BICD1 12 MEX3A 12 PHYHIP 12 RGMA 12 TMEM102 12ZKSCAN3 11 BIN2 12 MFSD12 12 PIP5K1C 12 RNASEK 12 TMEM132A 12 ZNF213 11 BLK 12 MGARP 12 PIP5K1P1 12 RNASEK- 12 TMEM163 12 ZNF277 11 BRAT1 12 MGRN1 12 PITPNC1 C170RF49 12 TMEM204 12 ZNF286B 11 BRSK2 12 MIR1224 12 PITPNM2 12 RPS6KA1 12 TMEM43 12 ZNF324 11 ClOorf105 12 MIR137HG 12 PITPNM3 12 RRAD 12 TMEM52B 12 ZNF331 11 C10orf76 12 MIR219-2 12 PKD2 12 S100A2 12 TNFRSF11A 12 ZNF354C 11 C11orf75 12 MIR2964A 12 PKD2L2 12 SATB2 12 TNFRSF6B 12 ZNF366 11 C11orf88 12 MIR3187 12 PKDREJ 12 SATB2-AS1 12 TNFRSF8 12 ZNF367 11 C16orf54 12 MIR3680-1 12 PKIA 12 SDR16C5 12 TNFSF12 12 ZNF414 11 C19orf43 12 MIR3680-2 12 PKNOX2 12 SECTM1 12 TNXA 12 ZNF461 11 C1QTNF3 12 MIR371A 12 PLEKHA6 12 SELPLG 12 TOP1 12 ZNF490 AMACR 12 MIR5093 12 PLP2 12 SEPT14 12 TOP1MT 12 ZNF512 11 Clorf2l 12 MIR5095 12 PMEPA1 12SGCE 12 TP73-AS1 12 ZNF542 11 C20orf197 12 MIR548AO 12PML 12SGCZ 12 TPBG 12 ZNF618 11 C20orf26 12 MIR5703 12 PNPT1 12 SH2D3C 12 TRAF3 12 ZNHIT6 11 C2CD4C 12 MMP21 12 POLE 12 SH3D21 12 TRAPPC10 12 ZSCAN1 11 C7orf65 12 MOCS3 12POMC 12 SHARPIN 12 TRIM43B 11AARS 11 C8orf42 12 MRPL15 12 POTEF 12 SHFM1 12 TRIML2 11 ABCA4 11 C8orf76 12 MS12 12 POU2AF1 12SHROOM1 12 TRMT1OA 11 ABHD13 11 C8orf82 12 MTMR14 12 PPCDC 12 SIRPB2 12 TRPC2 11 ABLIM3 11 C9orf40 12 MTTP 12 PPDPF 12 SLA2 12 TTC23L 11 ABP1 11 C9orf69 12 MYL7 12 PPIH 12 SLC10A4 12 TTC24 11 ACAA2 11 CACNA1C 12 MYO1G 12 PPP1CC 12 SLC13A4 12 TTC38 11ACOX3 11 CALHM3 12 MYO7A 12 PPP1R36 12 SLC22A4 12 TTC39A 11 ACSL1 11 CCDC33 12 MYOM3 12 PPP6C 12 SLC25A37 12 TTLL7 11 ADAMTS4 11 CCND2 12 NAP1L4 12PRDM8 12 SLC4A3 12 TUBB3 11ADD2 11 CD48 12NCDN 12 PRKRIR 12 SLC5A6 12 TXLNB 11AGRP 11 CD6 12 NCKAP5 12 PRMT2 12 SLC6A11 12 UBAC2 11 AGXT2L1 11 CD7 12 NCL 12 PROSAPIP1 12 SLC6A7 12 UBAP2 11 AIM 11 CDC14C 12 NDUFV1 12 PROX1 12 SLC7A7 12 UBE2D1 11 AJAP1 11 CDC42EP1 12NECAP1 12PRPF3 12SMARCAD1 12UBE2H 11AK7 11CDH9 12 NET1 12 PRR22 12 SMARCD1 12 UBOX5 11 AKIRIN2 11CDHR3

11 CDKL1 11 FOXP1 11 LINC00299 11 MYOMi 11 RBPMS2 11 TBC1D4 11 CELF4 11 FRG2 11 LINC00477 11 N4BP2L1 11 RDH12 11 TBC1D9 11 CENPT 11 FRG2B 11 LITAF 11 NADK 11 RELT 11 TCIRG1 11 CHD6 11 FRG2C 11 LMO4 11 NAT14 11 RGMB 11 TEKT4 11 CHST3 11 GALNT2 11 11 NAT2 11 RLTPR 11 TERF21P 11 CIRBP 11 GALNT5 LOC100128164 11 NCALD 11 RNASE4 11 TFDP1 11 CIRBP-AS1 11 GBF1 11 11 NDUFB6 11 RNF103 11 TG 11 CKAP2 11 GGTLC1 LOC100131551 11 NDUFS8 11 RNF157 11 TGFB1 11 CLASP2 11 GHDC 11 11 NEU3 11 RNF182 11 TGFB111 11 CLDN9 11 GLT1D1 LOC100288255 11 NEURL4 11 RNU6-19 11 TGM5 11 CLEC3B 11 GMFG 11 11 NFAM1 11 RPL1OL 11 THAP11 11 CLIC1 11 GORASP2 LOC100506585 11 NIPA2 11 RPL30 11 TIMP2 11 CLYBL 11 GPR108 11 11 NLRC4 11 RPP21 11 TIPARP 11 CNNM4 11 GRAMD2 LOC100507373 11 NLRP12 11 RPS4Y2 11 TIPARP-AS1 11 CPLX3 11 GRM4 11 11 NLRP3 11 RUNX1T1 11 TKT 11 CRNKL1 11 GTF2B LOC100507634 11 NMB 11 S100A4 11 TMEM120A 11 CRTC3 11 GXYLT2 11 11 NOMO1 11 SlOA5 11 TMEM196 11 CSF3R 11 HAUS3 LOC100653515 11 NOX4 11 S100A8 11 TNF 11 CSMD3 11 HCAR1 11 LOC200772 11 NPY1R 11 SASH3 11 TNFSF11 11 CTBP1 11 HCLS1 11 LOC283663 11 NR2E1 11 SBF2 11 TPD52L3 11 CXXC5 11 HDAC9 11 LOC286177 11 NR2F1 11 SBF2-AS1 11 TPM4 11 CYFIP1 11 HDGFRP2 11 LOC339166 11 NRD1 11 SCML4 11 TRAF31P3 11 CYP4F2 11 HECW1 11 LOC339975 11NSMCE1 11 SCNN1A 11TRAPPC9 11 DAXX 11 HIST1H1D 11 LOC375196 11 NSRP1 11 SCNN1D 11 TRIM14 11 DDO 11 HIST1H2AE 11 LOC389247 11 NUCB1 11 SCYLl 11 TRIP6 11 DDX19B 11 HIST1H4F 11 LOC400794 11 NUDT10 11 SEC31B 11 TRMT44 11 DDX25 11 HK1 11 LOC643401 11 OCSTAMP 11 SEC62 11TRNP1 11 DEF8 11 HLA-DOA 11 LOC646278 11 OSGIN2 11 SEMA4B 11TRPM6 11 DENND3 11 HLA-DQA2 11 LOC730668 11 OXT 11 SEPT10 11 TSHZ1 11 DLEU7 11HNRNPH1 11LPAR3 11 P2RY6 11 SERPINE2 11 TSPAN11 11 DLEU7-AS1 11 HOMERS 11 LPHN1 11 PCDHB5 11 SFRP4 11 TTLL10 11 DLL3 11 HSF5 11 LPPR4 11 PCGF1 11 SGK3 11 TTLL11 11DOM3Z 11HSPA4L 11LRPPRC 11PDE3B 11SGMS2 11TULP2 11 DSG3 11 HTR1B 11 LRRC24 11 PDE6B 11 SIX2 11TXNRD2 11 DUPD1 11 HUS1B 11LYRM2 11 PDLIM1 11 SLA 11 UBAC1 11 DYNC2H1 11 HYLS1 11 LYSMD4 11 PDLIM2 11 SLC12A4 11UBASH3B 11 EBF2 11 IKZF1 11 MAP3K5 11 PDS5B 11 SLC12A7 11 UBE2DNL 11EHHADH 11 IL28A 11 MAPK13 11PDZRN4 11 SLC12A9 11 UBE2U 11 EIF4A3 11 IL28B 11 MAPKAPK2 11 PET112 11 SLC18A2 11 UBN2 11 ELP6 11 IL2RG 11 MARCH 11 PID1 11 SLC19A1 11 UNC119B 11 ELSPBP1 11 ING2 11MARCH8 11 PIGH 11 SLC22A20 11 UROS 11 EMC10 11 IQUB 11 MARK2 11 PITX2 11 SLC25A24 11 USP24 11 EML4 11 ISOC1 11 MC3R 11 PITX3 11 SLC2A14 11 VPS28 11 ENPEP 11 ITGB5 11 MCM3 11 PIWILl 11 SLC38A1O 11 VPS36 11 EPDR1 11 ITPK1 11 MESDC1 11 PLEKHF2 11 SLC3A1 11 VPS39 11 EPRS 11 ITPRIP 11 MFAP1 11 PLOD1 11 SLC45A2 11 VWC2L 11 ERCC2 11 JAK1 11 MION 11 PLXND1 11 SLC6A2 11 WARS 11 ESYT2 11JPH1 11 MIPEPP3 11 PNPLA1 11 SLC9A9 11 WAS 11 ETS1 11 KARS 11 MIR142 11 PNPLA2 11 SLCO4A1 11 WBP1L 11 EXOC3 11 KATNB1 11 MIR1976 11 POLR1A 11 SLITRK5 11 WDFY4 11EXOSC6 11 KCNIP1 11 MIR423 11 PPP1R11 11 SMAP2 11 WDR17 11FABP7 11 KCNJl1 11 MIR4468 11 PPP1R12B 11 SMEK3P 11 WDR25 11 FAM171A1 11 KCNQ2 11 MIR4534 11 PRELID2 11 SNORA72 11 WDR73 11 FAM19A2 11 KDELC2 11 MIR4633 11 PRRC2C 11 SOGAl 11 WDR76 11 FAM228A 11 KDM4B 11 MIR5680 11 PRTN3 11SOWAHC 11 WDR86 11 FAM71E1 11 KIAA1210 11 MIR596 11 PSKH2 11 SPEG 11 WIPF3 11 FAM83F 11 KIAA1211 11 MMRN2 11 PSMA1 11 SPIRE2 11 WIP12 11 FAM8A1 11 KLHL25 11 MOB2 11 PSMB4 11 SPOCK3 11 WT1 11 FCGBP 11 KRT1 11 MOK 11 PTCD3 11SPTSSB 11 WWC3 11 FEZ2 11 KRT81 11 MS4A13 11PTCHD3 11 SQSTM1 11 WWTR1 11FGR 11 KRTAP5-6 11 MSH5 11PTGDR2 11 SRPK3 11 ZC3H12C 11 FLJ20518 11 KRTCAP3 11 MSH5- 11 PTPRJ 11 SRSF4 11 ZC3H4 11FLJ35946 11KSR2 SAPCD1 11PUS3 11STRA6 11ZCCHC2 11 FLJ39653 11 LAT 11 MST1P2 11 RAB25 11 STRN3 11ZCCHC7 11 FLJ45974 11 LDOC1L 11 MTUS1 11 RAB7A 11 SWAP70 11 ZFHX3 11FOXF1 11LGALS9C 11 MUC4 11RAB8B 11 TACR1 11ZFX 11 FOXF1-AS1 11 LIG4 11 MYH13 11 RASSF2 11 TAOK3 11 ZFX-AS1 11FOXN4 11LIN9 11 MYH9 11RBM8A 11TBC1D14

11 ZHX1- 10 c1S 10 DEDD2 10 GF11 10 LINC00478 10 MTIF2 C80RF76 10 Clorf1l 10 DFNA5 10 GFRAl 10 LINC00577 10 MTMR2 11 ZMAT5 10 Clorfl77 10 DISP1 10 GIMAP8 10 LINC00602 10 MXD3 11 ZNF101 10 C2CD2 10 DNAH5 10 GIPC1 10 LINC00637 10 NAIF1 11 ZNF131 10 C3 10 DNAJB13 10 GLUD2 10 LLGL1 10 NANP 11 ZNF251 10 C3orf38 10 DNER 10 GNA15 10 LMNA 10 NAT8 11 ZNF32 10 C3orf55 10 DNM3 10 GNA12 10 LMNB2 10 NAT8L 11 ZNF32-AS3 10 C3orf78 10 DNM3OS 10 GNE 10 10 NCR3LG1 11 ZNF324B 10 C6orf123 10 DOCK1 10 GNG5 LOC100129046 10 NFKBIE 11 ZNF549 10 C6orfl70 10EDNRA 10 GPR1 10 10 NKAIN3 11 ZNF57 10 C9orfl16 10 EIF2C2 10 GPR157 LOC100129620 10 NKIRAS2 11 ZNF610 10 C9orfl31 10 EIF3J 10 GRAMD3 10 10 NME7 11 ZNF628 10 CACTIN 10 EMC7 10 GRIA3 LOC100130417 10 NOD2 11 ZNF710 10 CALCB 10 EML1 10 GRIK4 10 10 NOVAl 11ZSCAN20 10 CAMSAP1 10ENG 10 GRK6 LOC100133669 10 NT5DC2 11ZSCAN21 10CANT1 10EPG5 10GRN 10 10NTAN1 10 AATF 10 CAPN2 10 ERBB2 10 GSTM4 LOC100134317 10 NTPCR 10 ABLIM2 10 CAPN8 10 ERGIC1 10 GTF3C3 10 10 NYX 10ACRBP 10 CARTPT 10 ERN2 10 GYG2 LOC100499227 10 OGT 10 ADORA2A 10 CBX7 10ESM1 10HADH 10 10 ONECUT3 10 ADRA1B 10 CCDC101 10 ESPNL 10HARS LOC100506274 10 OSBPL9 10 ADRA2A 10 CCDC144NL 10 EZR 10 HIF3A 10 LOC283683 10 P2RX1 10 ADSSL1 10 CCDC172 10 F11R 10 HIST1H31 10 LOC283688 10 P2RX2 10 AGPAT4 10 CCDC19 10 FAM131A 10 HIST1H4L 10 LOC441242 10 PAD14 10 AHCYL2 10 CCDC36 10 FAM136A 10 HMCN1 10 LOC643339 10 PAN2 10 ALMS1P 10 CCDC50 10 FAM157A 10 HNRNPF 10 LOC644669 10 PANX2 10AMN1 10 CCL3 10 FAM176A 10 HORMAD1 10 LOC645212 10 PAX7 10 ANK3 10 CCR1 10 FAM190B 10 HOTAIR 10 LOC727982 10 PC 10 ANKLE 10 CCT4 10 FAM194A 10 HOTAIRM1 10 LPP 1OPCDHAC1 10 ANKRD17 10 CD244 10 FAM208A 10 HOXAl 10LPPR5 10 PCDHB1 10 ANKRD27 10 CD37 10 FAM222A 10 HOXCl1 10 LRRC14B 10 PCDHB15 10ANO2 10 CD4 10 FAM222A-AS1 10 HS3ST3B1 10 LRRC15 10 PCDHB4 10 ARHGAP10 10 CDC42BPB 10 FAM227B 10 HSD11B1L 10LRTOMT 10 PCDHB7 10 ARHGAP26 10 CDK11B 10 FAM27L 10 HSD17B7 10 LTBR 10 PDCL3 10 ARHGAP31 10 CDK19 10 FAM49B 10 HSPA6 10 LUC7L3 10 PDE12 10 ARHGEF9 10 CECR2 10 FAM59B 10 HTR4 10LYPD6 10 PDE1C 10ARIDlA 10 CGGBP1 10FAM5C 10IER3 1OLYPD8 10PDGFD 10 ARNT2 10 CHECK 10 FAM73A 10 IFRD1 10 MAN2B1 10 PDLIM4 10 ARR3 10 CHSY1 10 FAM78A 10 IKBKG 10 MBD5 10 PDZD4 10 ARRB2 10 CLDN2 10FANCG 10 IL17RE 10 MCAT 10PECAM1 10 ARSI 10 CLDN4 10 FAP 10 ILRN 10 MEFV 10 PEX14 10 AS3MT 10 CLIP2 10 FBLIM1 10 IL23A 10 MFSD6 10 PGBD4 10 ASB16 10 CLNK 10 FBLN2 10 IL2RB 10 MFSD7 10 P116 10 ATG16L2 10 CLVS2 10 FBXO17 10INPP4A 10 MGC12916 10 PILRA 10 ATL2 10 CMTM2 10 FBXO4 10 IQCD 10 MIR1297 10 PLCH1 10 ATP5F1 10 CNGB1 10FCER2 10IRF2 10 MIR199A2 10 PLD4 10 ATP6V1H 10CNNM2 10FGD1 10 ISCU 10 MIR2110 10 PLEK 10AUH 10 CNTN4 10 FGF23 10 ITGA11 10 MIR3545 10 PLEKHG4B 10AURKB 10 COA5 10 FIBCD1 10 JAKMIP3 10 MIR369 10 PLVAP 10 B3GNT9 10 COL27A1 10 FIGNL1 10JAZF1 10 MIR409 10 POP7 10BAHCC1 10 COXi0 10 FLJ16171 10 KCNH2 10 MIR410 10 PPIA 10BANP 10 COX10-AS1 10 FLJ25758 10 KCNJ5 10 MIR412 10 PPIG 10 BCL2L1 10 CPT1C 10 FLOT1 10 KHDRBS1 10 MIR541 10 PPP1R13B 10 BCL2L14 10 CPT2 10 FLYWCH2 10 KIAA0930 10 MIR548AA2 10 PPP1R1B 10 BIN1 10 CRB3 10 FMR1NB 10 KIAA1598 10 MIR548AN 10 PPP1R9A 10 BIRC8 10 CSRP3 10FXYD1 10 KIF1B 10 MIR548D2 10 PPP2R2C 10BPGM 10 CTSF 10FXYD7 10 KIF21B 10 MIR656 10 PRAP1 10 ClOorf9O 10 CTTN 10 G6PD 10 KIF6 10 MMP11 10 PRDM15 10 C11orf45 10 CULl 10 GABARAPL1 10 KRT7 10 MMP17 10 PRH1-PRR4 10 Cllorf54 10 CUL3 10 GABRD 10 KRT80 10 MPL 10 PRICKLE1 10 Cllorf67 10 CX3CR1 10 GABRR3 10 LAIR1 10 MRPL23 10 PRL 10 C12orf29 10 CXorf65 10 GALNS 10LEPR 10 MRPL4 10 PRRT3 10 C15orf53 10 CYP20A1 10 GALNT12 10 LG14 10 MRPL52 10 PRRT3-AS1 10 C16orf11 10 CYP27C1 10 GAPDH 10LGR6 10 MRPS2 10 PSMA4 10 C16orf74 10 DAZAP1 10 GAS2L2 10 LHX3 10 MRPS21 10 PTAFR 10 C17orf65 10 DCBLD1 10 GATA2 10 LIMK2 10 MT1A 10 PTPN4 10 C17orf96 10 DD11 10 GATA5 10 LINC00226 10 MT1DP 10 PTPN7 10 C19orf38 10 DDR1 10 GBA 10 LINC00466 10 MT1L 1OPYGO1

10 RAB1lFIP1 10 SPNS2 10 ZNF527 9 CLDN15 9 GD12 9 KRTAP2-1 10 RAB24 10 SRL 10 ZNF589 9 CLEC16A 9 GGA3 9LAMTOR1 10 RAB41 10SRPRB 10 ZXDC 9 CLEC5A 9 GGACT 9 LARS2 10 RA114 10 ST6GAL1 9AARD 9 CLK2 9 GLB1L3 9 LCA5 10 RAPGEFL1 10 ST6GALNAC2 9 ABCA2 9 CLPB 9 GLUD1 9 LEFTY2 10 RASGRF1 10 ST8SIA2 9 ABHD11 9 CMYA5 9GMDS 9 LETMD1 10 RASIP1 10 STARD10 9 ACOXL 9COQ5 9 GP9 9 LIN7A 10 RASSF5 10 STARD3 9 ADAMTS7 9 CORO1C 9 GPR153 9 LINC00475 10 RASSF9 10 STX16 9 ADAMTSL3 9 COTL1 9 GPR21 9 LINC00628 10 RBPJL 10 SULF1 9 ADAP1 9 COX17 9 GPR84 9 LIPT1 10 RCBTB2 10 SULF2 9 ADCY7 9 CPEB3 9 GPSM1 9 LOC100128076 10 RERE 10 SUMF1 9 AIG1 9 CRABP1 9 GPX3 9 LOC100128568 10 RFTN1 10 SVOPL 9 AKAP7 9 CRELD2 9 GPX7 9 LOC100130950 10 RGS9BP 10 SYT14 9 ALDH3A1 9 CRISPLD2 9 GRAMD4 9 LOC100132111 10RHOG 10 TAF1D 9AMACR 9 CRSP8P 9 GRAP2 9 LOC100271702 10 RHPN2 10 TAF4B 9 AMIGO3 9 CSNK1G3 9 GTF2A1 9 LOC100630923 10 RIN1 10TBRG4 9 AMZ1 9 CTAGE11P 9 GTF2H4 9 LOC254312 10 RINL 10 TET1 9 AP1M2 9 CTSO 9 GTF3C4 9 LOC257358 10 RNU6-66 10 THBS1 9 AQP10 9 CXorf2l 9 H2BFWT 9 LOC284276 10RORC 10THEGL 9 ARF4 9 CYB5B 9 HAS2 9 LOC339524 10 RPL36 10THRAP3 9 ARFRP1 9 CYP46A1 9 HAS2-AS1 9 LRAT 10 RPS19BP1 10 THY1 9 ARHGAP4 9 DAAM2 9 HAVCR1 9 LRIG1 10 RPS3A 10 TIAF1 9 ARHGDIA 9 DCDC2 9 HBEGF 9 LRRC27 10 RPS6KA2-IT1 10TMCC1 9 ARHGEF2 9 DDX31 9 HDDC3 9 LRRC32 10 RPS6KA3 10 TMEM108 9 ASCC2 9 DEDD 9HDGF 9LRRC4C 10 RRAGD 10 TMEM176A 9 ATOH8 9 DEPDC7 9 HELLS 9LRRC8C 10 RSF1 10 TMEM176B 9 ATP8B2 9 DERL1 9 HEXB 9LRTM2 10 S1OA1 10 TMEM249 9 AZU1 9 DEXI 9 HIST1H2APS1 9 MAEA 10 S100A13 10 TMEM72 9 B3GAT1 9 DLL4 9 HLA-DMB 9 MAF 10 SAP30BP 10 TNFRSF4 9 BECN1 9 DNA1l 9 HLA-H 9 MAFG 10 SART3 10TNN 9 BST1 9 DPP10 9 HLX 9 MAFG-AS1 10 SCARB1 10 TNNT2 9 BTBD18 9 DSC2 9HNRNPM 9 MAP1LC3B2 10 SCARF1 10 TNS3 9 BTG4 9 DTL 9 HOXC5 9 MAP3K10 10 SCARF2 10 TOR3A 9 ClOorfl07 9 DTX4 9 HOXC6 9 MAP4K2 10 SCNlA 10 TPH1 9 C11orf49 9 EFCAB10 9 HRASLS 9 MAPK81P1 10 SDC4 10 TRIM72 9 C11orf92 9 EFEMP2 9 HRH1 9 MAPK81P3 10 SEC14L1 10 TRIP 9 C11orf93 9 EFR3A 9 HSBP1 9 MDFIC 10 SERBP1 10 TRPV3 9 C16orf91 9 ELL3 9 HTRA3 9 MEGF11 10 SERPINAl 10 TSPAN14 9 C19orf53 9 ELMO1 9 HUS1 9 MEGF6 10 SERPINB9 10 TTC25 9 C22orf13 9 EPHA4 9 ICMT 9 MESP1 10 SESN2 10TUB 9 C2orf18 9 FAM120B 9 IFF02 9 MESP2 10 SIDT2 10 ULK2 9 C2orf27B 9 FAM131B 9 IGF1R 9 MGAT4B 10 SLC11A2 10 UNC50 9 C5orf55 9 FAM155A 9IGFBP1 9 MGC2889 10 SLC17A7 10 UPF2 9 C8orf46 9 FAM183B 9 IGFLR1 9 MGLL 10 SLC22A16 10 USP22 9 C9orf139 9 FAM18B1 9 IL20RB 9 MIR138-2 10 SLC25A18 10 USP9X 9 CA7 9 FAM18B2 91NCA1 9 MIR1468 10 SLC25A25 10 UST 9 CACNA1C-IT3 9 FAM18B2- 9INPP1 9 MIR150 10 SLC25A44 10 VCX 9 CACNA1H CDRT4 9INTS7 9 MIR34B 10 SLC27A1 10VKORC1 9CADM2 9 FAM195A 9IPCEF1 9 MIR34C 10 SLC27A2 10 WDR1 9 CALR 9 FAM219B 9IQGAP3 9 MIR4489 10 SLC2A13 10 WDR67 9 CASKIN1 9 FAM40A 9IRF7 9 MIR615 10 SLC35F3 10 WDR77 9 CCDC112 9 FAM60A 9 ITGA2B 9 MIR618 10 SLC4A7 10 WSCD2 9 CCDC67 9 FAM81A 9 ITGB3 9 MLIP 10 SLC52A2 10 WWOX 9 CCDC81 9 FBXL8 9 ITPK1-AS1 9 MOB3B 10 SLC6A20 10 YY2 9CCM2 9 FCRL6 9 IVNS1ABP 9 MONlA 10 SLC06A1 10 ZBTB43 9 CCNJL 9 FHL3 9 IZUMO4 9MPO 10 SLIT1 10 ZC3H14 9 CCR10 9 FL11 9JUNB 9 MR1 10 SMAD9 10 ZC4H2 9 CD28 9 FLJ27354 9 KCNE1 9 MRGPRF 10 SMTN 10 ZFR 9 CDC25A 9 FOLR3 9 KCNIP3 9 MTL5 10 SMYD4 10 ZG16B 9 CDC42EP4 9 FOXA2 9 KCNMB3 9 MUMi 10 SNORD73A 10 ZNF185 9 CDH1 9 FRMD4B 9 KIAA0319 9 MYH14 10 SNORD93 10 ZNF200 9 CDH2 9 FSDlL 9 KIAA0947 9 MYL9 10 SNRNP27 10 ZNF26 9 CDK20 9 FUT7 9 KIAA1199 9 MYLK2 10 SNX6 10 ZNF280B 9 CEACAM21 9 GABRQ 9 KIF1C 9 MYO1A 10 SORL1 10 ZNF284 9 CHD2 9 GAGE12J 9 KLHL21 9 MYOlC 10 SPi10 10 ZNF343 9 CHD9 9 GALNT14 9 KLHL31 9 MYO3A 10 SP140 10 ZNF44 9 CHST2 9 GCNT2 9 KRT16P3 9 N4BP3 10 SPATA5 10 ZNF507 9 CIAO1 9GCOM1 9 KRT3 9 NAALADL2

9 NACA2 9 RNF216 9 TMX2-CTNND1 8 C11orf95 8FFAR2 8 MINPP1 9 NACAP1 9 RP1-177G6.2 9 TNFAIP2 8 C16orf45 8 FLJ13197 8 MIR3202-2 9 NBEAL2 9 RPF1 9 TNIK 8 Clorf173 8 FNIP2 8 MIR365A 9 NCF2 9 RPL31P11 9 TNN12 8 Clorf98 8 FOXJ2 8 MIR4444-1 9 NCKAP5L 9 RPS6KL1 9TOMM7 8 C2orf7O 8FOXK2 8 MIR4456 9 NCLN 9 RRN3P2 9 TP53BP2 8 C5orf49 8 FTX 8 MIR516B2 9NDRG3 9 RRP12 9 TP73 8 CA5A 8 FXR1 8 MIR52OG 9NDRG4 9 RTN2 9 TPO 8 CA6 8 GARS 8 MK1671P 9 NEK6 9 S100P 9TRADD 8 CABIN1 8 GGT1 8 MKS1 9 NGB 9 SAE1 9 TRAF5 8 CACNA1A 8 GJB1 8 MSRB1 9 NIM1 9 SCD 9 TRANK1 8 CACNA1D 8 GLB1 8 MST1R 9 NIPSNAP1 9 SCIMP 9 TRMT10C 8 CAMKK2 8 GLCC11 8 MT1IP 9NLRC3 9SERF2 9TSGA10 8CAMKMT 8GLRA2 8MTFMT 9 NLRP14 9 SERPINB6 9 UBE2E1 8CASS4 8 GPIHBP1 8 MUCl5 9 NMD3 9 SERPINB8 9 UBE2MP1 8CCAR1 8 GPR114 8 MYO1F 9 NOL4 9 SERTAD2 9 UBXN11 8 CCDC11 8 GRIA4 8 MZB1 9 NPEPL1 9 SETDlA 9 UCHL3 8 CCDC144B 8 GRIN3A 8NECAB2 9NRGN 9SGCB 9 UNC45A 8 CCDC155 8GSDMB 8NEDDl 9 NUB1 9 SH3BP2 9 USPi 8CCDC9 8HENMT1 8 NIT2 9 OR9Q2 9 SIAE 9 UTP23 8 CCL24 8 HK3 8 NOD1 9 OSBPL10 9 SKIL 9 UVRAG 8 CCL25 8 HNFlA-ASl 8 NOLCl 9 OTUD3 9 SLC22A8 9 VARS2 8 CCNBIP1 8HTR3A 8 NOP14 9 OXAlL 9 SLC25A17 9 VGLL3 8 CD22 8 ILl7RC 8NSUN5 9 PACS1 9 SLC26A6 9 VWA3B 8 CD300C 8ISPD 8 OPLAH 9 PARP11 9 SLC2Al 9 WDR90 8 CD33 8 ITGAM 8 ORMDL3 9 PCNXL2 9 SLC2A6 9 XKR6 8CD5 81TK 8OTOF 9 PDE3A 9 SLC35C2 9 YTHDC1 8 CD83 8 IZUMO1 8 OVOLl 9 PDGFB 9 SLC35E2B 9 ZBBX 8 CDC26 8JPX 8 PACRG-ASl 9 PGAM1 9 SLC38A9 9 ZGPAT 8 CDH12 8KCNA3 8 PACSIN2 9PGAM4 9 SLC39A12 9 ZHX1 8 CDK3 8KCNH3 8 PAD13 9 PIEZO1 9 SLC43A3 9 ZNF329 8CDYL 8KCNN3 8PAPSS2 9 PIK3CD 9 SLC8A2 9 ZNF385C 8CFHR5 8 KIAA0895L 8PAQR3 9 PINX1 9 SLFN5 9 ZNF446 8 CHRNA10 8 KIFlA 8PCCA 9 PKIG 9 SOCS3 9 ZNF530 8 CLDN10 8 KLF3 8PCDH9 9PLEKHO2 9SPAl7 9ZNF555 8 CLPSL2 8 KLHL29 8PCDHB9 9PNMA2 9SPAG16 9ZNF564 8CLRN1 8KRT2 8 PCDHGB8P 9 PNMAL2 9 SPG7 9 ZNF578 8CNTD2 8LASP1 8 PDE1B 9 POLR2M 9SPOCD1 9 ZNF672 8 CORO1A 8LDLRAD3 8PGBD5 9 PPFIA1 9SRM 9 ZNF716 8 COX7A1 8 LILRB3 8 PHF8 9 PPM1N 9 SRPK2 9 ZNF747 8 CPM 8 LINC00652 8 PIK3R2 9 PPP5D1 9 STRAP 9 ZNF772 8CRCP 8 LINC00674 8 PITPNA 9 PRIM1 9 STXBP5L 9 ZNRF1 8CROCCP3 8LMO1 8PKP3 9PRKCDBP 9SUSD5 9ZSCAN18 8 CYP26B1 8 LOC100216546 8PLEKHA7 9 PRKRIP1 9 SYN2 9 ZSCAN30 8DBNDD1 8 LOC100270804 8 PLEKHG3 9 PRMT7 9SYNGR3 8ABCG1 8 DEFB1 8 LOC100499489 8 PMS1 9 PRR23A 9SYNPO 8 ACLY 8DEGS2 8 LOC100506207 8PNKD 9 PRRT4 9 TADA3 8 ADAMTS19 8 DGAT2L6 8 LOC255512 8POLR3G 9PSEN2 9TBC1D20 8AGPAT3 8 DNAH14 8 LOC340357 8PPAP2A 9 PSENEN 9 TBR1 8AHNAK 8 DNAJC5 8 LOC348761 8PPP1CA 9PSTK 9TBX22 8AKTIP 8DSE 8 LOC374443 8PPP3R2 9PTP4A2 9TCEAL5 8AMPD2 8 EAF1 8 LOC606724 8PREPL 9 PTPRH 9 TCF7L1 8 ANKLE2 8 EEF1Al 8 LOC641746 8 PROS1 9 R3HCC1L 9 TEAD1 8ANO5 8EFHD2 8 LOC731223 8 PRPF4 9RAB31L1 9TFDP3 8AP2S1 8 EGFL7 8 LPO 8 PRPF8 9RABGAP1 9TGFA 8APOBEC3B 8EHDl 8LRCH1 8PSD4 9 RAD54L2 9 TGFBR2 8APOBEC3H 8 EMID1 8LRG1 8PTH2R 9RANBP3 9TGFBRAP1 8ARHGEF26 8ERBB21P 8LRP6 8PTPLAD1 9 RASGEFlA 9 THSD1 8 ARHGEF26- 8ERBB4 8LRRC73 8PTPN18 9 RASL10A 9 TIMP4 AS1 8 EVL 8LZTFL1 8PTPRO 9 RBMY2EP 9 TM4SF19 8 ARID5A 8 EXOC3L1 8MADCAM1 8PTX4 9 RCSDl 9 TM4SF19- 8AVP 8 EXOC3L2 8 MAP3K1 8 RAD23A 9RFPL2 TCTEX1D2 8BAHD1 8EYS 8 MAP3K14 8 RAD50 9 RGS2 9 TMEM105 8 BCL10 8 FAM63A 8 MAPKAPK3 8RAMP2 9RHOB 9 TMEM127 8 BCL2L10 8FANCA 8 MAST1 8 RAMP2-AS1 9 RIF1 9 TMEM184A 8 BICD2 8FARS2 8 MB21D2 8 RAPGEF4-AS1 9 RNF10 9 TMEM200B 8 BIN3 8FBXO41 8 MBDl 8 RBMXL2 9 RNF123 9 TMEM44-ASl 8BNC2 8FCHO1 8 MBLAC2 8REEP4 9 RNF213 9 TMEM45B 8 C11orf87 8FEM1A 8 MCRSl 8 RFWD3

8 RNASE2 8 VSIG4 7 DNMT3B 7 LINC00629 7 PTCRA 7 VPS18 8 RNF138P1 8 WDR52 7 DNPEP 7 LMAN2L 7 PTPRQ 7 WBSCR17 8 RNF167 8 WNK1 7 DRP2 7 LOC100128881 7 PXMP4 7 WDR26 8 RNF6 8 XCR1 7 DYRK2 7 LOC100130776 7 RAB40C 7 WDR81 8 ROPN1L 8YTHDF2 7 EFCAB9 7 LOC100288748 7 RAB44 7 WNK2 8 RP9P 8 ZCCHC16 7 EIF3G 7 LOC100507443 7 RAD18 7ZCCHC5 8 RPP25 8ZFP36L1 7ESRP1 7 LOC283403 7RBM38 7ZFAND2B 8RRM2 8ZFP42 7 ETV1 7 LOC344967 7 RBM5 7 ZFAT 8 SAMD14 8 ZNF148 7 ETV3L 7 LRIG3 7 REPS2 7 ZNF124 8 SCAF1 8 ZNF239 7 EXOC3L4 7 LRRC20 7 RGL4 7 ZNF204P 8SCAMP2 8 ZNF451 7 EXTL3 7 LRRC43 7 RLF 7 ZNF398 8SCRN1 7ABCG4 7 FAAH 7LSM7 7 RNF126 7 ZNF415 8 SEMA6B 7 AB13 7 FAM129C 7 LURAP1 7 RNF19B 7 ZNF503 8SETDB1 7 ACTN1 7 FAM173A 7 LY6H 7 RPL39L 7 ZNF503-AS2 8 SLC11A1 7 ADCK3 7 FAM173B 7 MAG 7 SAFB 7 ZNF512B 8SLC25A11 7 AMICAl 7 FAM48B2 7 MAP3K14-AS1 7 SEC61A2 7 ZNF548 8SLC25A4 7 ANKIB1 7 FAM71Fl 7 MAPT 7 SEMA7A 6 ACAT2 8 SLC25A42 7 ANKRD44 7 FCGR3B 7 ME1 7 SERPINB13 6 ADAMTS3 8SLC34A1 7 APLP2 7 FERMT2 7 MEIOB 7 SGK110 6 ADARB1 8 SLC35B3 7 ARHGAP9 7 FLT1 7 MFSD6L 7 SHKBP1 6 AD11 8SLC9A3R2 7 ARHGEF1 7FOXN3 7 MGC16121 7 SLAMF8 6 ALOX15P1 8 SLIT3 7 ATF7 7 FRMD6 7 MGC34034 7 SLC1A3 6 APOLD1 8 SMOX 7 ATG2A 7 FSDl 7 MIR1204 7 SLC25A2 6 AQP8 8 SNORA30 7 BACH2 7 FTSJD1 7 MIR182 7SMCHD1 6 ARHGAP6 8 SNRK 7 BDH1 7 GAGE13 7 MIR1915 7SNCG 6 ARL15 8 SNX22 7 BMP8B 7 GAK 7 MIR192 7 SP8 6 ARPC1B 8 SOX15 7 BSCL2 7 GMCL1P1 7 MIR194-2 7 SPPL2B 6 ATP1B1 8SPATA3 7 BTBD8 7 GNG3 7 MIR1973 7 SPTBN1 6 ATP5G2 8 SPO11 7 ClOorfl14 7 GNGT2 7 MIR3124 7 SRD5A2 6 BAIAP3 8SRCAP 7 C15orf52 7 GOLIM4 7 MIR3186 7 STAT3 6 BCL6B 8 SRSF1 7 C16orf7 7 GP1BA 7 MIR4673 7 STK17B 6 BCL7A 8STAC 7 C18orf26 7 GPR128 7 MIR542 7 STON2 6 BFSP2 8STAT5A 7 C19orf71 7 GRM8 7 MIR548N 7 SUGT1P1 6 BIRC7 8 SUV39H1 7 Clorf200 7 GYPC 7 MS4A6A 7SYNGR1 6 C12orf23 8 SUZ12P1 7 C1orf86 7 HAUS5 7 MTHFD1L 7 TAGLN2 6 Cl2orf6O 8 SYNM 7 C20orf201 7 HBS1L 7 MYCL1 7 TDGF1 6 C16orf93 8 TAF2 7 C2orf68 7 HCG11 7 MYL6B 7 TERF1 6 C17orf75 8TBXA2R 7 CAMK2G 7 HCN2 7 MYO3B 7 TESC 6 C18orfl 8TCEA2 7 CARNS1 7 HIST1H2BO 7 MYSM1 7 TEX26 6 C19orf55 8TCEB3C 7 CBX2 7 HIST1H3J 7 NELF 7 TFAP2A 6 Cl9orf6O 8TCERG1L 7 CBX3P2 7 HNRNPUL2- 7 NFKBIL1 7 TINAGL1 6 ClQTNF4 8TCF3 7 CCDC12 BSCL2 7 NOL7 7 TJP2 6 C1QTNF9 8 TCFL5 7 CCDC167 7 HOXAl0 7 NOP14-AS1 7 TMEM169 6 C1orf159 8TCTN3 7 CCDC69 7 HOXAl0- 7 NOTCH 7 TMEM63A 6 C5orf43 8TELO2 7 CCND1 HOXA9 7 NPLOC4 7 TMIGD2 6 C9orf41 8TEN1 7 CCT5 7 HSD17B12 7 NTHL1 7 TMPRSS13 6 CA14 8 TEN1-CDK3 7 CD36 7 HTR6 7 NUDT14 7TNPO2 6CACNG8 8 TEX26-AS1 7 CDC42EP3 7 IGF2BP1 7 OPRL1 7 TONSL 6 CALM 8THBS2 7CDCA3 71GSF9 70R8U8 7TPT1-AS1 6CAPN3 8TLR9 7 CDKN1C 7 IL27 70S9 7 TREML2 6 CARD8 8TM2D3 7 CES1 7 IRF2BP1 7 PAD12 7 TRIM42 6 CASP10 8 TMEM187 7 CHD3 7 ITGA5 7 PAPD5 7 TRPC7 6 CBLC 8 TMEM246 7 CLIC3 7 KAAG1 7 PARVB 7 TSC2 6 CBLL1 8 TOLLIP 7 COAl 7 KANK3 7 PCED1B 7TSNARE1 6 CCDC144A 8 TOM1Ll 7COG8 7 KATNBL1 7 PDF 7 TSPAN9 6 CCDC148 8TRAM2 7 COX16 7 KBTBD13 7PECR 7 TSPO 6 CCDC150 8 TRIM26 7 CPNE2 7 KCNAB2 7 PHCl 7 TSSC1 6 CCDC64B 8TRNT1 7 CPNE9 7 KCNN4 7 PHF15 7TTN 6CCNK 8TRPC5 7 CPZ 7 KIAA0195 7 PIK3R1 7 TTN-AS1 6 CD82 8TRPM5 7 CRYGD 7 KIAA1683 7 PILRB 7 TUBB1 6 CDC14B 8TSHR 7 CUL2 7 KLHDC4 7 PLA2G4D 7 TUSC2 6 CDCA2 8TSPY3 7CUL5 7KLHDC8A 7PLEKHM2 7U2AF2 6CDKALl 8TSPYL1 7DCAF6 7KLHL24 7PNP 7UBE2M 6 CDT1 8TTC7A 7 DECR1 7 KPNAl 7 POMGNT1 7UROC1 6 CHN2 8UBR4 7 DEFB132 7 KRIT1 7 PPP6R2 7 USP20 6 CLDN23 8 UMODLl 7 DHCR24 7 LEFTY 7PRCC 7 USP39 6 CLDND1 8UNCX 7 DHRSl1 7 LINC00324 7 PRKCD 7 USP5 6 CLEC2B 8VAX2 7 DKFZP434A062 7 LINC00592 7 PRKG2 7 VAV2 6 CLEC4A

6 CNR2 6 HNRNPU 6 MYOF 6 SPAM1 5 AQP1 5 CLSTN3 6 COL6A1 6 HSPB6 6 MYOM2 6 SPEN 5 ARHGEF1OL 5 CNGA4 6 COL7A1 6 HSPBP1 6 NAPA 6 SPIN2A 5 ARHGEF12 5 COG2 6 CPSF6 6 IER5 6 NAPA-AS1 6 SPON2 5 ARMCX4 5 COL19A1 6 CPXM2 6 IF130 6 NCAM2 6 SRSF2 5ARRDC1 5 CPNE5 6 CSF1R 6 IL13RA2 6 NCOA2 6 ST18 5 ASB18 5 CPSF1 6 CSNK1D 6 IST1 6 NDE1 6 SUFU 5 ASB2 5 CRIP2 6 CWH43 6 JAK3 6 NFKBIZ 6 TACC1 5 ASGR2 5 CSNK1G2 6 D2HGDH 6 KCNC1 6 NHLRC1 6 TAF1A 5 ASZ1 5 CT47B1 6 DBF4B 6 KCNMB2 6 NLRP1 6 TAS2R40 5 ATAD3C 5 CTBP1-AS1 6 DCHS1 6 KCTD10 6 NPHP4 6 TBC1D15 5 ATP2C2 5 CTBS 6DDX54 6KCTD11 6NQO2 6TBKBP1 5ATP5L2 5CTDNEP1 6DGKA 6KCTD7 6NR4A3 6TCF15 5ATP8B3 5CTGF 6DHRS7 6KCTD9 6NSD1 6TEX10 5ATP9B 5CTSG 6 DHX40 6 KDELR2 6 NTN5 6 TEX11 5 ATPIF1 5 CYP2D7P1 6 DNAJB12 6 KDM3A 6 NUP188 6 TIGD1 5 ATXN7 5 CYP2W1 6 DOK4 6 KIAA1715 6 OGFR 6 TIPRL 5 AVPR2 5 DCAF12L2 6 DOLK 6 KIF13A 6 OPA3 6TMCC3 5 AXDND1 5 DDX50 6 DRD5 6 KIF7 6 OR2L13 6 TMEM131 5 B3GALNT1 5 DHRS9 6 DSCAML1 6 KLHL26 6 OR8H2 6 TMEM135 5 B3GNT7 5 DHX16 6 DUOX2 6 KPTN 6 OXER1 6 TMEM154 5 B4GALT3 5 DHX37 6 DUOXAl 6 KRCC1 6 PAX3 6 TMEM57 5 BCAS3 5 DMKN 6 DUOXA2 6 LAMB3 6 PDZRN3 6 TMEM79 5 BCAT1 5 DNAJC8 6 DYNC112 6LAMTOR3 6 PHKG2 6 TMEM95 5 BMP7 5 DUSP6 6 EFS 6LAMTOR4 6 PKP4 6 TNFAIP8L1 5 BNIP3L 5 DYNC111 6 EIF4E2 6 LARP1B 6 PMF1-BGLAP 6 TNFAIP8L3 5 BPI 5 DYNLL1 6 ELANE 6 LINC00264 6 PNMA3 6TNFRSF19 5 BR13BP 5ECHDC1 6 EML6 6 LINC00441 6PNOC 6 TNFRSF21 5 C11orf58 5EDAR 6 EPHA7 6 LINC00476 6 POMT1 6TOM1 5 C12orf44 5 EEF1D 6 ERCC6L2 6 LINGO3 6 PPAP2B 6TOPORS 5 C15orf55 5 EFHB 6 ERF 6 LIPH 6 PPM1G 6 TPRA1 5 C16orf5 5 ELAVL3 6 ETNK1 6LMAN2 6 PPP2R5C 6 TRIT1 5 C16orf58 5 ELF1 6 EXOC6 6 LOC100128071 6 PRMT6 6 TSSK3 5 Cl9orf10 5 ELP5 6 FAM127B 6 LOC100128338 6PROCR 6 TTYH2 5 C1QL4 5 EML5 6 FAM133B 6 LOC100128770 6 PRSS57 6 TUBA1A 5 C1QTNF8 5 ENTHD1 6 FAM133DP 6 LOC100129250 6 PSMC1 6TYMP 5 Clorfl27 5 EP400 6 FAM159A 6 LOC100129345 6 PTGES 6 UCN2 5 Clorfl74 5 EPAS1 6 FAM174A 6 LOC100129518 6 PTPRG 6UNG 5 C2orf29 5 EPB41 6 FAM18A 6 LOC285696 6 RALA 6 UPP1 5 C7orf26 5 EPCAM 6 FAM83D 6 LOC494141 6 RALGPS2 6 VRK1 5 CAMKK1 5 EPN1 6 FBN3 6 LOC574538 6 RAVER1 6 WBP11 5 CAP2 5 EPN3 6 FBXL6 6LRCH2 6 RBFOX2 6 WRNIP1 5 CARS 5 ERICH1 6FBXO44 6LRRC71 6RBMXL3 6XPO6 5CASP2 5EXD3 6FBXO6 6LRRFIP1 6RFNG 6ZBTB8A 5CAV2 5EXOSC1 6 FER1L4 6 MACF1 6 RGL3 6 ZFAND2A 5 CCDC137 5 EXOSC7 6 FER1L5 6 MANBA 6 RGS22 6 ZFP14 5 CCDC140 5F8 6 FGFR3 6 MAP3K12 6 RHBDL3 6 ZFR2 5 CCDC146 5 F8A1 6 FLJ30403 6 MAP3K13 6 RNF185 6 ZHX2 5CCDC15 5 F8A2 6 FNDC3B 6 MAPKBP1 6 RNF19A 6 ZMYND11 5 CCDC24 5 F8A3 6 FOXD4L1 6 MED12L 6 RNF40 6 ZNF300P1 5 CCDC42 5 FAM169B 6FOXP2 6MED25 6RTDR1 6ZNF7 5CCDC88C 5FAM22F 6 FRRS1L 6 METTL17 6 RTKN 6 ZNF862 5 CCDC92 5 FBXO15 6FUOM 6 METTL9 6SCO2 5 ABCC3 5 CCIN 5 FBXO47 6FUZ 6MFNG 6SCTR 5ABHD3 5CCT3 5FKBP4 6GDNF 6 MFSD11 6SDK1 5ACADS 5 CD300LG 5 FLAD1 6 GEMIN4 6 MGC16275 6 SEC1P 5ACADSB 5 CD44 5 FLT4 6 GFRA2 6 MIAT 6 SEPT4 5 ACOT13 5 CDAN1 5FOXD2 6 GGA1 6 MIR3196 6 SERPINB5 5 ACTL9 5 CDC16 5 FTSJ3 6 GPHN 6 MIR4664 6 SETD3 5 ADAMTS18 5 CDH22 5 FZR1 6 GPR37 6 MIR5001 6 SFTPA1 5 AKNA 5 CDK14 5 GALR2 6 GPR77 6 MIR636 6 SGK1 5 ALG1L 5CDO1 5 GCAT 6 GPS1 6 MLK7-AS1 6 SGSM1 5 ANGEL2 5 CECR5 5 GCFC2 6 GPX1 6 MOGAT3 6 SGTA 5 ANKRD30BP2 5 CECR5-AS1 5 GJB2 6 GRID21P 6 MORF4L2 6 SLAMF1 5 ANKRD33 5 CECR7 5 GJC2 6GRM3 6 MORF4L2-AS1 6 SLC38A2 5 ANXA2R 5 CELF2 5 GLIS1 6 HELZ 6 MRPS7 6SMG5 5 ANXA9 5 CEP170 5 GNPNAT1 6 HEPH 6 MTNR1A 6 SOWAHD 5AOAH 5 CHST13 5 GPR137B 6 HIP1 6 MYBPC3 6 SP1 5 AP1S2 5 CIDEB 5 GPR78

5 GPRC5A 5 MIR4520B 5 SFMBT2 5 ULK4 4 ATP9A 4 CMTM8 5 GRIK3 5 MIR4710 5 SFSWAP 5 VENTX 4 AVP11 4 CNGAl 5 GRIPAP1 5 MIR4801 5 SH2D3A 5 WAC 4 B4GALT1 4 CNR1 5GSG1L 5 MLLT4 5 SH3TC2 5 WDFY3 4 BCAP31 4 COL15Al 5 GSTA4 5 MLLT4-AS1 5SHROOM2 5 WDFY3-AS2 4 BEX4 4 COL25A1 5 H1FO 5 MRVI1 5 SIGLEC9 5 ZAP70 4 BGLAP 4 COL4A5 5 H2AFB1 5 MXRA5 5 SLC1A7 5 ZDHHC16 4 BMP4 4 COL4A6 5 H2AFB3 5 NAA60 5 SLC25A52 5 ZDHHC17 4 BMP6 4COMT 5 HCRTR1 5NAGK 5 SLC35A3 5ZDHHC3 4 BMPER 4 COX19 5 HMGXB3 5 NAP1L6 5 SLC46A1 5 ZIC2 4 BRD4 4 COX412 5HNRNPCL1 5NAT9 5SLC52A3 5ZMAT2 4BTAF1 4CPEB4 5 HNRNPK 5 NCR2 5 SLC5A2 5 ZNF222 4 BTBD16 4CPQ 5 HOXB-AS3 5NDOR1 5 SLC5A8 5 ZNF34 4 BTBD17 4 CPSF4L 5HOXC8 5 NDUFAF4 5 SLC6A19 5 ZNF365 4 BTRC 4 CPT1B 5 HRASLS2 5 NDUFB4 5 SLC9A1 5 ZNF470 4 BUB1B 4 CREB3L1 5 HS3ST2 5 NECAB3 5 SLITRK2 5 ZNF518A 4 C1orf11 4 CREBBP 5 HSPA2 5 NEU4 5 SLX4 5 ZNF536 4 Cl7orf110 4CRK 5 HTR3E 5 NFE2L2 5 SMC2 5 ZNF574 4 C17orf62 4 CRYM 5 ICAM2 5 NFIA 5 SOCS2 5 ZNF615 4 C19orfl2 4 CRYM-AS1 51GDCC4 5 NKAPL 5 SOCS2-AS1 5 ZNF653 4 C19orf47 4 CSDC2 5 IKZF5 5NOM1 5 SOD2 5 ZNF738 4 C1QTNF3 4 CSNK1A1 5 IL11RA 5 NOP10 5 SOX11 5 ZNF80 4 C1QTNF6 4 CSRNP1 5 IL7REL 5 NUDT4 5 SPATS2L 5 ZNHIT1 4 C1orf5O 4 CTNNBIP1 5INTS6 5 NUDT4P1 5 SPDL1 5 ZNRF2 4 C3orf74 4 CTR9 5ISLR2 5 NUPL1 5 SPSB1 5 ZSCAN23 4 C5orf45 4 CUEDC1 5 ITGBL1 5 OLFM2 5 SRCIN1 4 AlBG-AS1 4 C6orfl36 4 CUL4A 5 ITIH3 5 OR5AP2 5 SRP68 4 ABAT 4 C6orfl95 4 CWC25 5JMJD8 5 OR6B2 5 SSTR5 4 ABCB4 4 C6orf89 4 CXCR2 5 KBTBD11 5 ORC2 5 ST8SIA6 4 ABCB9 4 C9orf3 4 CYB561D2 5 KCNE1L 5 OTOP3 5 STAMBP 4 ABCD1 4 C9orf66 4 DAPK3 5 KIAA0754 5 OXLD1 5 STK24 4 ABCF3 4 CACNA1F 4 DARC 5 KIAA0922 5 PAK3 5 STX11 4 ABHD15 4 CALML6 4 DBIL5P 5 KIAA1239 5 PARD6G 5 STXBP2 4 ACIN1 4 CAMK2B 4 DBNL 5 KLRG1 5PCDHGC3 5 SUCLG2 4 ACOT7 4 CAPN1 4 DCAF16 5 KSR1 5 PEAR1 5 SYPL1 4 ACOT9 4 CASP8 4 DCSTAMP 5 LANCL2 5PER1 5TC2N 4ACTL8 4CBY1 4DDC 5 LILRA1 5 PIP5K1A 5 TCF7 4 ACTN4 4 CCBL2 4 DGKI 5 LINCO0511 5 PIR 5 TDP2 4 ADAMTS5 4 CCDC106 4DGKQ 5 LINC00606 5 PIR-FIGF 5TDRD5 4 ADAMTS9 4 CCDC22 4DGUOK 5 LMAN1L 5 PIWIL3 5TDRD9 4 ADCY2 4 CCDC57 4 DIRAS2 5 LOC100128098 5 PKNOX1 5TECPR1 4 AEN 4CCDC8 4 DIRC3 5 LOC100130539 5 PLCG1 5 TEPP 4 AFG3L1P 4CCNG2 4 DNAH6 5 LOC100130872 5 PLOD3 5 TFE3 4 AGBL3 4 CD247 4 DNAJA2 5 LOC100131655 5 PLXNB1 5TGM2 4AGT 4 CD68 4 DNAL11 5 LOC100132077 5 PLXNC1 5 THEMIS2 4 AIFM3 4 CD8A 4 DOCK6 5 LOC100132987 5 PMF1 5 TICRR 4 AK4 4 CDH18 4 DOCK8 5 LOC100498859 5POGZ 5 TLE2 4 ALDH1A3 4 CDH20 4 DPYSL3 5 LOC100505495 5PORCN 5 TMEFF2 4 AMOTL1 4 CDH7 4 DPYSL4 5 LOC100506668 5 POU5F1P3 5 TMEM139 4 ANK2 4 CDK4 4 DRAXIN 5 LOC147670 5 PPARD 5 TMEM171 4 ANKRD34B 4 CDPF1 4 DSCR6 5 LOC150185 5 PPM1B 5 TMEM181 4 ANKRD63 4 CDSN 4 DUSP22 5 LOC220906 5 PSMC5 5 TMEM190 4 ANKS1A 4 CEACAM1 4 DVL1 5 LOC283731 5 RAB36 5 TMEM241 4 ANKS3 4 CEACAM6 4 DYSF 5 LOC339442 5 RASSF1 5 TMEM56- 4 ANXA11 4 CENPBD1 4 ECELlP2 5 LOC643529 5 RBP5 RWDD3 4 APBB3 4 CEP55 4 ECT2L 5 LOC649330 5 REREP3 5 TMPRSS4 4 APC2 4 CES1P1 4 EFCAB4A 5 LOH12CR1 5 RGS19 5 TMPRSS4-AS1 4 ARFIP2 4 CFLAR 4 EFCAB4B 5LRRN4 5 RGS20 5 TMSB15A 4 ARL10 4 CHADL 4 EFCAB5 5 LTB4R 5RHOH 5 TOP1P2 4 ARMCX5- 4CHGA 4 EIF5 5 MAGOHB 5 RHOXF2 5TPM2 GPRASP2 4 CHKB-CPT1B 4 ELOVL4 5 MAP3K9 5 RHOXF2B 5TPM3 4 ASB1 4CHML 4 EME2 5 MAP4K4 5 RM11 5 TRIM16 4 ASIC2 4 CHMP4C 4 EMP3 5 MARCKSL1 5 RNF111 5 TSACC 4 ASPG 4CHRM5 4 ENTPD3 5 MED29 5 RPS15A 5 TSPY8 4 ATAD3B 4 CHRNB2 4 EPHA8 5 MED31 5 RWDD3 5 UBAC2-AS1 4 ATAT1 4 CKB 4 EPM2AIP1 5 MFF 5SAMD4A 5 UBE2D2 4ATP5J2 4CLDN5 4ER11 5 MIER2 5 SELK 5 UBE2E2 4 ATP5J2-PTCD1 4 CLIP1 4 ERO1LB 5 MIR320C1 5 SEPHS2 5 ULK1 4 ATP5S 4 CMBL 4 ESYT3

4 EXOSC2 4 HHAT 4 LOC100130992 4 MIR3917 4 PAFAH1B3 4 RNF11 4 F12 4 HHIPL2 4 LOC100131060 4 MIR4505 4 PARP10 4 RNF13 4 FAIM2 4 HIGDlA 4 LOC100131626 4 MIR4657 4 PAWR 4 RNF212 4 FAM101A 4 HILPDA 4 LOC100131825 4 MIR4727 4 PAXIP1 4 RNF222 4 FAM102B 4 HMG20A 4 LOC100144603 4 MIR4728 4 PCDH11X 4 ROBO4 4 FAM171B 4 HMGA2 4 LOC100188947 4 MIR548F5 4 PCDHB14 4 ROR2 4 FAM200B 4 HOXA11-AS 4 LOC100287944 4 MIR5580 4 PCID2 4 RPL22 4 FAM219A 4 HOXB2 4 4 MIR561 4 PCMT1 4 RPL36A 4 FAM227A 4 HOXB3 LOC100499484- 4 MIR5691 4 PDE2A 4 RPL36A 4 FAM5B 4 HOXB5 C90RF174 4 MIR602 4 PDGFRB HNRNPH2 4 FAM78B 4 HSD3B7 4 LOC100505583 4 MIR609 4 PEAK1 4 RPS15 4 FARP2 4 HSF4 4 LOC100505875 4 MIR675 4 PER2 4 RPS26 4 FBXO25 4 HSPB9 4 LOC100506229 4 MIR935 4 PF4V1 4 RPSAP58 4 FGF14 4 IFITM10 4 LOC100507066 4 MKNK1 4 PGAP2 4 RRAGA 4 FGF14-AS2 4 IFITM4P 4 LOC100507564 4 MKRN9P 4 PHC2 4 RSBN1 4 FGF14-IT1 41FT88 4 LOC100996307 4 MLH1 4 PHKB 4 RSPH3 4 FIGNL2 4IGSF9B 4 LOC150197 4 MOCS1 4 PIPSL 4 RTN4 4 FLJ22184 4 ILl7RD 4 LOC151171 4 MORF4L1 4 PLD3 4 RUSC1 4 FLJ33534 4 IL19 4 LOC202781 4 MPRIP 4 PLEKHM3 4 RUSC1-AS1 4 FLJ35390 4INHBE 4 LOC255130 4 MPZ 4 PLXNB3 4 RYK 4 FLJ46257 4ITFG1 4 LOC283194 4 MRPL16 4 PODNL1 4 SAFB2 4 FLNC 4 ITGA3 4 LOC284837 4 MRPL55 4 PP12613 4SAP18 4 FOXN3-AS1 4 JAKMIP2 4 LOC284865 4 MRPS28 4 PPAN-P2RY11 4 SBK1 4 FXC1 4 JAKMIP2-AS1 4 LOC344887 4 MRPS34 4 PPP1R3D 4 SCAND2 4 FXR2 4JTB 4 LOC348120 4 MS4A15 4 PPP1R3G 4 SCARNA13 4FXYD6 4JUP 4LOC400685 4 MSX2P1 4PPP2CA 4SCN4B 4 FXYD6-FXYD2 4 KALRN 4 LOC401109 4 MTF1 4 PPP2R5A 4 SCN9A 4GABRG3 4KANK4 4LOC440563 4MX2 4PPP3CB 4SCP2 4 GATSL3 4 KAT2A 4 LOC440944 4 MYBPC2 4PRAME 4 SCUBE2 4 GBX1 4 KCNAB1 4 LOC541473 4 MYH1l 4 PREP 4 SDC1 4 GDAP1 4 KCNB1 4 LOC644189 4 MYO1D 4 PRKAR2B 4SDHC 4 GDPD5 4 KCNJ8 4 LOC648691 4 MYO1E 4 PROB1 4 SEC23B 4 GEMIN7 4 KCTD16 4 LOC648809 4 MZT2B 4 PROCAl 4 SENP7 4 GIP 4 KDM1A 4 LOC728392 4 NACC2 4 PRR19 4 SERTM1 4GL13 4KHK 4LONRF2 4NAV3 4PRR23B 4SETD5 4 GLRA1 4 KIAA0247 4LRGUK 4 NCAPG 4 PRRT2 4 SFT2D3 4 GLRX5 4 KIAA1191 4 LRRC14 4 NDST4 4 PRSS16 4SGCD 4 GLS2 4 KIAA1462 4LRRC2 4 NDUFAF5 4 PRSS27 4 SGOL1 4 GLYATL3 4 KIF19 4 LRRC45 4 NEAT1 4PSMG2 4SGSM3 4 GNB1 4 KLF13 4 LRRC8B 4 NEK9 4 PSTPIP2 4 SH2D7 4 GNG11 4 KLF2 4 LTB4R2 4 NEURL 4 PTGIS 4 SH3RF1 4GP6 4KLHDC2 4 LYPLA1 4NEXN 4PTPRC 4SHBG 4GPATCH3 4KLK1 4LYSMD2 4NF1 4PTPRN 4SHE 4 GPD2 4 KLK15 4 LZTR1 4 NFYC 4 PTPRR 4 SHISA6 4 GPN2 4 KLK6 4 MAGEA2 4 NHEJ1 4PURB 4SHROOM4 4 GPR124 4 KNDC1 4 MAGEA2B 4 NKD1 4 PUSL1 4 SIK2 4 GPRASP2 4 KRT17 4 MAG11 4 NME3 4 PXDC1 4 SKAP1 4 GPS2 4 KRT36 4 MAGOH 4NMS 4 PYY 4 SLC16A3 4 GRIN2A 4 KRT8 4 MAL 4 NODAL 4 QSER1 4 SLClA5 4 GRINA 4 KRT86 4 MAOB 4 NOTCH4 4 QSOX2 4 SLC1A6 4GRK4 4KRT8P41 4 MAP3K3 4NPAS3 4RAB12 4SLC23A1 4GRM6 4 L2HGDH 4 MAP4K1 4 NPRL2 4 RAB4A 4 SLC25A23 4 GTF2A1L 4 LAMA5 4 MAP7D2 4 NRL 4 RAC3 4 SLC25A3 4 GTPBP1 4 LAMB2 4 MARCH10 4 NTF3 4 RALGPS1 4 SLC25A30 4 GUCY1B2 4 LDHAL6B 4 MARCH9 4 NUDT1 4 RASA4CP 4 SLC26A10 4 GUCY2C 4LDHC 4 MARCO 4 NUMAl 4 RASALl 4 SLC2A1-AS1 4GULP1 4LEPRE1 4 MARS2 4NUP43 4RBM4B 4SLC35A4 4 GXYLT1 4LEPROT 4 MATR3 4 NUP98 4 RBMXL1 4 SLC35G1 4 H19 4 LGALS3BP 4 MAZ 4 NXF3 4 RBMY1F 4 SLC38A11 4 H3F3B 4 LHX6 4 MBOAT7 4 OAT 4 RELL2 4 SLC38A7 4 HDAC11 4 LIN7B 4 MDM1 4 ODF2L 4 REM1 4 SLC39A11 4 HDAC3 4 LINCO0028 4 MEDAG 4 OPN3 4 REXO2 4 SLC39A14 4 HDAC7 4 LINCO0163 4 METTL10 4 OR7G3 4 RFX4 4 SLC39A4 4 HECTD2 4 LINC00273 4 METTL14 4 ORAOV1 4RGN 4 SLC4Al1 4 HECW2 4 LINCO0523 4 MFAP4 4 OSBPL3 4 RGS6 4 SLC5Al1 4 HEPHL1 4 LMLN 4 MF12-AS1 4 OSR1 4RHCG 4 SLC9A3Rl 4 HEXIM1 4 LOC100129917 4 MGAT1 4 PABPC5 4 RLIM 4 SLCO1Cl 4 HEYL 4 LOC100130557 4 MIR3649 4 PAD11 4 RND2 4 SLMAP

4 SLPI 4 TRIM74 3 ADAMTSL5 3 C19orf26 3 COL20A1 3 FAIM3 4 SMG9 4TRPM8 3 ADCY4 3 C19orf45 3 COL8A1 3 FAM111B 4 SMPD4 4 TSHZ3 3 ADO 3 C19orf6 3 COLQ 3 FAM127C 4 SMPDL3A 4 TSPAN10 3 AFAP1Ll 3 C1QTNF2 3 COMMD3-BMI1 3 FAM134A 4 SNAR-Cl 4 TSPAN15 3 AGXT2L2 3 C1orf123 3COMMD7 3 FAM134B 4 SNAR-C2 4 TTC30B 3 AHCTF1 3 C1orf170 3 COX7C 3 FAM150B 4 SNAR-C5 4 TTC34 3 AKR7L 3 Clorf210 3 CPA2 3 FAM175B 4 SNHG10 4 TTC9B 3 AKT2 3 C1orf52 3 CPNE7 3 FAM176B 4 SNHG16 4 TTLL4 3 ALKBH5 3 C20orf112 3 CPSF3 3 FAM176C 4 SNIP1 4 TTPAL 3 ALPPL2 3 C21orf33 3 CREB3L3 3 FAM182B 4 SNORDlA 4 TUSC3 3 ALS2CR8 3 C22orf26 3 CREB5 3 FAM188B 4 SNORD1B 4 TYR 3AMDHD1 3 C2orf50 3 CRHR1 3 FAM193B 4 SNORDlC 4 UBA7 3 ANGPTL2 3 C3orf62 3 CRX 3 FAM82A1 4 SNRPE 4UCN 3 ANGPTL6 3 C3orf72 3CS 3 FAM83G 4 SNX10 4 UCN3 3ANKH 3 C6orfl 3 CSF3 3 FAM98B 4 SOCS1 4UMOD 3ANKMY1 3 C6orfl20 3 CTDSPL 3 FASTKD3 4SOCS7 4UNK 3ANKRD34A 3 C7orfl0 3 CXADR 3 FBXL14 4 SOX18 4 UNQ6494 3 ANKRD39 3 C7orf4l 3 CXCL12 3 FBXO27 4 SP3 4 UPF3A 3 ANP32C 3 C7orf55- 3 CYB561D1 3 FBXW4 4 SP6 4 UQCRFS1 3 ANXA6 LUC7L2 3 CYCl 3FCHSD1 4 SPAG11A 4 USP19 3 AOX2P 3 C8orf44 3 CYLD 3FERMT1 4 SPAG9 4 USP6 3 AP4E1 3 C8orf48 3 CYP11A1 3 FEZF2 4 SPINK13 4 VAC14 3 AP5S1 3 C9orfl71 3 CYP2D6 3FGD2 4 SPNS1 4 VAT1 3 APOA2 3 C9orfl74 3 DAPK2 3 FGFBP2 4SPNS3 4VCX3A 3APOBEC3A 3CAl1 3DBP 3FHDC1 4 SRY 4 WDR45 3 APOBEC3C 3 CACNA1B 3 DCAF12 3 FIBIN 4 SSR4P1 4 WDR96 3APOF 3 CACNA2D3 3 DCAF12L1 3 FITM1 4 SSX6 4 WIBG 3 AQP2 3 CALHM2 3 DCAF8L2 3 FKBP1A 4 ST6GAL2 4 WISP3 3 AQP5 3 CAPN12 3 DDX1lL10 SDCBP2 4 STARD5 4 WNT5A 3 ARHGAP15 3 CARD10 3 D102 3 FLJ23152 4STMN1 4XK 3 ARHGEF16 3 CASP3 3 D102-AS1 3 FLJ30679 4 STOML1 4 XRCC3 3 ARID5B 3 CASR 3 DISP2 3 FLJ43663 4 STRBP 4 YIF1B 3 ARL3 3 CAV3 3 DLX6-AS1 3 FLJ43860 4 STX1A 4 ZBTB1 3 ARL4A 3 CBFA2T2 3 DMAP1 3 FLVCR2 4SUSD3 4ZBTB25 3ARRDC5 3 CBX5 3 DNAH7 3FOXL2 4SYBU 4ZBTB9 3ASB13 3 CCDC107 3 DNAJC11 3 FSD2 4 SYCN 4 ZEB1 3 ASIC3 3 CCDC111 3 DOC2GP 3 FUCA2 4 SYNE1 4 ZEB1-AS1 3 ASS1 3 CCDC53 3 DOCK5 3 FUT3 4 TAF7L 4 ZFAND4 3 ATL 3 CCDC77 3 DOT1L 3FXYD2 4TARM1 4 ZFP82 3 ATL3 3 CCDC83 3 DSP 3 FYB 4 TBC1D9B 4 ZMIZ2 3 ATP6VOA2 3 CCDC86 3 DUSP14 3 GALNT13 4 TCEB3CL 4 ZNF221 3 ATP6V1B1 3 CCT7 3 DUSP5 3 GAP43 4TDRD10 4ZNF238 3ATP6V1F 3 CD180 3 DUSP8 3GAS2 4TDRKH 4 ZNF280C 3 AXL 3 CD320 3 E2F6 3 GEMIN6 4TFB1M 4ZNF425 3 B3GALTL 3 CD52 3 ECE2 3GFER 4 THAP4 4 ZNF516 3 B3GAT2 3 CD55 3 EDF1 3 GGNBP1 4THG1L 4 ZNF575 3 B3GNT3 3 CD72 3 EHD3 3 GIPC3 4 TIMM13 4 ZNF583 3 B9D1 3 CD79A 3 EIF2B3 3 GLB1L 4 TLK2 4 ZNF586 3 BAK1 3 CDCP2 3 EIF5A2 3 GLI1 4 TLR3 4 ZNF664- 3 BATF2 3 CDHR2 3 ELFN2 3 GLOD5 4 TM9SF1 FAM101A 3 BBX 3 CDK5 3 ELN 3 GNA11 4 TMA16 4 ZNF681 3 BCL2A1 3 CDK5R1 3 ELOVL5 3 GNA13 4TMC4 4 ZNF71 3 BCORL1 3 CDK9 3 EMBP1 3 GNL3 4 TMEM101 4 ZNF728 3 BIK 3CDON 3ENDOG 3 GP1BB 4 TMEM130 4 ZNF850 3 BLOC1S4 3 CEP164 3 ENOSF1 3 GPKOW 4 TMEM155 4 ZNF878 3 BMI1 3 CHAMP 3 EPB41L1 3 GPR142 4 TMEM158 3 A2M-AS1 3BOC 3 CHD5 3 EPB41L3 3 GPR35 4 TMEM177 3 AARS2 3BOD1 3 CHMP2A 3 EPB41L5 3 GPR56 4 TMEM40 3 ABCB7 3 BRD1 3 CHRNA4 3 EPC2 3 GPT2 4TMEM5 3 ABCB8 3 BTBD1 3 CHRNB1 3 EPHAl0 3 GRIK5 4 TMEM51 3 ABI1 3 BTG2 3 CILP 3 EPS15L1 3GRM2 4TMEM61 3ACBD5 3BTLA 3CLCN1 3EPS8L2 3 H3F3A 4TMEM9 3 ACP6 3 C14orf182 3 CLDN6 3 ER13 3 H3F3AP4 4 TMIE 3 ACTB 3 C15orf27 3 CLMP 3 ESPNP 3 H6PD 4 TNFRSF13B 3 ACVR2B 3 C16orf46 3 CMPK1 3 ESR1 3HAMP 4 TPCN2 3 ACVR2B-AS1 3 C17orfl03 3 CMTM4 3 ESRP2 3 HARS2 4 TRAF1 3 ADAM22 3 C17orfl09 3 CNFN 3 EXO1 3 HCAR2 4 TRIM73 3 ADAM33 3 C17orf53 3 COIL 3 EYA4 3 HCG22

3 HDDC2 3 LOC100292680 3 MIXL1 3 PBRM1 3 RPL27A 3 SSPN 3 HEG1 3 LOC100499484 3 MKLN1 3 PCSK9 3 RPL3 3 SSPO 3 HIC2 3 LOC100505549 3 MLF1 3 PCTP 3 RPS20 3 SSTR4 3 HIF1A-AS2 3 LOC100505622 3 MLKL 3 PDLIM5 3 RSPH9 3 ST3GAL1 3 HKR1 3 LOC100506178 3 MLNR 3 PDP2 3 RSPO1 3 ST6GALNAC4 3 HLA-DRB5 3 LOC100506710 3 MMP23A 3 PDYN 3 RSPO3 3 STAP2 3 HLA-F-AS1 3 LOC100507299 3 MORN1 3 PEX11G 3 RUNX3 3 STAT2 3 HNRNPA1 3 LOC100652768 3 MPHOSPH8 3 PEX5 3 RWDD2B 3 STC2 3 HNRNPA1P10 3 LOC150381 3 MPND 3 PHLDA2 3 RXFP4 3 STIP1 3 HS1BP3 3 LOC155060 3 MPP2 3 PIGQ 3 SAMD12 3 STK16 3 HS6ST3 3 LOC255167 3 MPPED2 3 PINLYP 3 SARM1 3 STPG2 3 HSD17B7P2 3 LOC339505 3 MRFAP1 3 PKN3 3 SASH1 3 STUB1 3 HTRA1 3 LOC375295 3 MRPL23-AS1 3 PLA2G3 3 SCMH1 3 STX1B 3 IFITM3 3 LOC389705 3 MRPL28 3 PLXNB2 3 SDCBP2 3 SUB1 3 IKZF2 3 LOC401320 3 MRPS15 3 POLR3GL 3 SDCBP2-AS1 3 SULT1Al 3 ILl7C 3 LOC644248 3 MRRF 3 POM121 3 SDF2 3 SUPT6H 3 ILl8BP 3 LOC644554 3 MS4A3 3 POM121C 3 SEPHS1 3 SYN3 3 IL20RA 3 LOC728175 3 MSH3 3 POU2F2 3 SEPT 3 SYNC 3 IL4R 3 LOC730227 3 MTA3 3 POU5F1B 3 SEPT5-GP1BB 3 SYNCRIP 3 INMT-FAM188B 3 LOC730811 3 MTCH1 3 PPAN 3 SERP2 3SYNGR2 3INPPL1 3 LOC90834 3 MTHFD1 3 PPFIA4 3 SERPINA10 3 SYT17 3ISYNA1 3 LOXL2 3 MTHFD2 3 PPFIBP2 3 SET 3 SYT3 3 ITGB1 3 LPIN2 3 MTHFSD 3 PPIL6 3 SFTA3 3 SYT8 3 ITGB1BP1 3LRFN4 3 MTMR7 3 PPP1R26 3SGMS1 3 SYTL3 3JAM3 3 LRIT1 3 MTPAP 3 PPP1R7 3 SH3BP4 3 TAGLN 3JMJD1C 3 LRRC33 3 MTRR 3 PPP2R5B 3 SIGLEC10 3TARS 3KCNG3 3 LSAMP 3 MUC2 3 PRADC1 3 SIGLEC12 3 TBC1D13 3 KCNG4 3LSM3 3 MUC5B 3 PRDX2 3 SIRT1 3 TBC1D2B 3 KCNK10 3 LTBP2 3 MYF5 3 PRKDC 3 SIRT7 3 TBK1 3 KCP 3 LTK 3 MYO1B 3PROSC 3 SKP1 3 TCEA3 3 KDM5A 3 LUC7L2 3 MYZAP 3 PRR15 3 SLC15A4 3 TCL1A 3 KIAA0226L 3LYPD6B 3 NAV2 3 PSMB2 3 SLCl9A3 3 TCL1B 3 KIAA0284 3 MAB21Li 3 NBEA 3 PSME1 3 SLC26A11 3 TEAD3 3 KIAA1161 3 MAGEC1 3 NCAPH 3 PTCH1 3 SLC26A9 3 TFR2 3 KIAA1217 3 MAGEC3 3 NEBL 3 PTCH2 3 SLC38A8 3THUMPD1 3 KIAA1467 3 MAGT1 3 NEK10 3PTGFRN 3 SLC44A4 3 TIAM2 3 KIAA1671 3 MAL2 3 NEK8 3 RABGAP1L 3 SLC4A2 3 TK2 3 KIAA1804 3 MANEAL 3 NFKB1 3 RABL2B 3 SLC51B 3 TMBIM1 3 KIF2A 3 MAP4K5 3 NHLRC4 3 RABL5 3 SLC5Al0 3 TMBIM6 3 KIF3A 3 MAPK4 3 NISCH 3 RAC2 3 SLC6A12 3 TMEM119 3 KLK11 3 MDFI 3NONO 3 RAD21 3 SLC7A4 3 TMEM179 3 KLK12 3 MEF2A 3NOXO1 3 RAD21-AS1 3 SMAD7 3 TMEM185B 3 KRT77 3 MEF2B 3 NPM2 3 RAMP1 3 SMC5 3 TMEM27 3 L1TD1 3 MEF2BNB- 3 NPTX2 3 RBBP6 3 SMPD2 3 TMEM30B 3LAG3 MEF2B 3 NR2F6 3 RBL1 3SNCA 3 TMEM44 3 LAMC1 3 METTL8 3 NRF1 3 RBL2 3 SNORA21 3 TMEM45A 3LAMC3 3 MFSD1 3 NRP1 3 RBM18 3 SNORA3 3 TMEM53 3 LAMP3 3 MFSD10 3 NRP2 3 RBMY1J 3 SNORA45 3 TMPRSS3 3 LAX1 3 MGC57346 3 NUCKS1 3 RBMY2FP 3 SNORD105 3 TNFRSF12A 3LCN8 3 MICALL2 3 NUP210 3 RFX7 3 SNORD19B 3 TNIP2 3 LCP1 3 MIER1 3 NXNL1 3RGAG4 3 SNORD54 3 TNK2 3 LEF1 3 MIIP 3 OCELl 3RGR 3 SNORD69 3 TNRC6A 3 LEF1-AS1 3 MINA 3 OLFML2B 3 RGS3 3 SNORD83A 3 TNS1 3LENG8 3 MIR1234 3 OMAl 3 RHBDL1 3 SNORD83B 3 TOMM40L 3 LGALS7B 3 MIR1275 3 OR7C1 3RHOF 3 SNRNP48 3 TOR1B 3LGMN 3 MIR2861 3 OSCP1 3RHOU 3 SNRPB2 3 TP53BP1 3 LILRA4 3 MIR3150B 3 OSTCP1 3 RILP 3 SOBP 3 TPTE 3 LINCO0202 3 MIR3607 3 P2RY10 3 RIMS1 3 SOX5 3 TRAF2 3 LINCO0240 3 MIR3615 3 P2RY2 3 RNASEH2A 3 SOX7 3 TRAF4 3 LINCO0265 3 MIR3960 3 PABPC1 3 RNF138 3 SP140L 3 TRAPPC1 3 LINCO0313 3 MIR4285 3 PAEP 3 RNLS 3 SPATA18 3TRDMT1 3 LINCO0319 3 MIR4298 3 PAFAH2 3 RNU5D-1 3 SPATA2 3TREH 3 LINCO0612 3 MIR4520A 3 PAK7 3 RNU5E-1 3 SPIRE1 3 TRIM 3 LIPJ 3 MIR4669 3 PALM 3 RNU6-28 3 SPOCK2 3 TRMT1L 3 LMTK2 3 MIR5187 3PAQR5 3 RPH3A 3 SPTBN2 3TRPM1 3 LMX1B 3 MIR548G 3 PARP12 3 RPL23 3 SQLE 3 TTC7B 3 LOC100009676 3 MIR641 3 PASK 3 RPL23AP53 3SRC 3 TTC9 3 LOC100132354 3 MIR661 3 PAX5 3 RPL23AP82 3SRMS 3 TTLL6

3UBLCP1 2ACVR2A 2ATP6V1G1 2C2CD4B 2CEP85 2CSRNP3 3 UHRF2 2 ACVRL1 2 ATP6V1G2- 2 C2orf4O 2 CERKL 2 CST6 3 UNC119 2 ACYP1 DDX39B 2 C2orf54 2 CES3 2 CTIF 3 UPF1 2 ADAM15 2 ATPAF1 2 C3orfl7 2 CFD 2 CTSC 3 UPK1B 2 ADAMTS14 2 ATPAF1-AS1 2 C3orf27 2 CGB2 2 CTSW 3 UPK2 2 ADAT3 2 AZIN1 2 C3orf32 2 CHAD 2 CTTNBP2NL 3 UQCC 2 ADCK5 2 B3GALT5 2 C3orf36 2 CHD4 2 CTXN1 3 USP16 2 ADD3 2 B3GNT5 2 C3orf37 2 CH13L1 2 CXCL10 3 USP47 2 ADNP 2 BACE2 2 C4orf2l 2 CHIC1 2 CXCL5 3 VAMP8 2 ADORA2B 2 BACH1 2 C4orf27 2 CHRD 2 CXCR1 3 VANGL2 2 ADRA2B 2 BARHL2 2 C5AR1 2 CHRNA5 2 CXCR5 3 VDAC1 2 AGBL2 2 BCAM 2 C5orf24 2 CHRND 2 CYBASC3 3 VOPP1 2 AGK 2 BCDIN3D-AS1 2 C6orfl0 2 CHRNE 2 CYP19A1 3VSTM5 2AGXT 2 BCL9 2 C6orfl5 2 CHST10 2 CYP1B1 3 VTN 2 AK8 2 BCL9L 2 C6orfl64 2 CHST9 2 CYP1B1-AS1 3 VTRNA2-1 2 AKR7A2 2 BEAN1 2 C7orf55 2 CHTF18 2 CYP2F1 3 VWCE 2 ALDH1Li-AS2 2 BEND7 2 C7orf69 2 CKAP2L 2 CYP2S1 3 WBP2NL 2 ALDH1L2 2 BEST 2 C8orf3l 2 CKS1B 2 CYP4F24P 3 WBSCR27 2 ALDH2 2 BET3L 2 C8orf34 2 CLCN4 2 CYTH3 3 WDR12 2 ALG13 2 BEX5 2 C9orfl69 2 CLCN5 2 DAGLA 3 WDR18 2 ALG14 2 BGN 2 C9orf50 2 CLCNKB 2 DAGLB 3 WDR78 2 ALG6 2 BHLHA15 2 C9orf9 2 CLDN7 2 DAP3 3 WDTC1 2 ALPL 2 BHLHE41 2 CA12 2 CLDN8 2 DCAF17 3 WFS1 2 ALS2 2 BLVRA 2 CABLES 2 CLEC12B 2 DCAF5 3 VVHAMM 2 AMN 2 BLZF1 2 CACNA2D2 2 CLEC14A 2 DCDC2B 3 WISP1 2 AMPH 2 BMF 2 CACNB3 2 CLEC1A 2 DCLRE1A 3XAGE5 2ANAPC16 2BMPR1B 2CACYBP 2CLK3 2DCTPP1 3 XPC 2 ANKK1 2 BMPR2 2 CADM1 2 CLN5 2 DDIT3 3 XRCC1 2 ANTXR1 2 BMX 2 CALCOCO2 2 CLTCL1 2 DDX11L2 3YBX2 2ANXA1 2BOP1 2CAMP 2CMC1 2DDX27 3 YEATS2 2 AP1B1 2 BRF2 2 CAPN14 2 CMC2 2 DDX39B 3 YVVHAQ 2 AP1S3 2 BSN 2 CARD6 2 CMSS1 2 DEFA4 3 ZAK 2 AP3M2 2 BTBD3 2 CASKIN2 2 CMTM7 2 DENNDlA 3ZBED3 2 AP4B1-AS1 2 BTC 2 CASP4 2 CNEP1R1 2 DES 3 ZBED3-AS1 2 AP5Z1 2 BTN3A3 2 CBX1 2 CNIH 2 DGKG 3 ZBTB11 2 APBB1IP 2 BUB3 2 CCDC102A 2 CNIH3 2 DHX15 3 ZBTB38 2 APMAP 2 Clorf131 2 CCDC105 2 CNKSR2 2 DHX29 3 ZC3H7A 2 APOL4 2 Cl0orf54 2 CCDC136 2 CNKSR3 2 DHX57 3 ZFP1 2 APP 2 C10orf88 2 CCDC144C 2 CNOT6 2 DID01 3 ZIM3 2 APPL2 2 Cl0orf9l 2 CCDC151 2 CNTFR 2 DIXDC1 3 ZNF169 2 ARC 2 Cl0orf95 2 CCDC28B 2 CNTNAP3 2 DLG5 3 ZNF274 2 ARHGAP18 2 Cl2orfl0 2 CCDC40 2 COBL 2 DLGAP4 3 ZNF292 2 ARHGAP21 2 C12orf65 2 CCDC42B 2 COBRAl 2 DMPK 3 ZNF37A 2 ARHGAP29 2 C14orf64 2 CCDC71 2 COCH 2 DMTF1 3 ZNF395 2 ARHGAP35 2 Cl5orf4l 2 CCDC85C 2 COL12A1 2 DMXL2 3 ZNF496 2 ARHGDIB 2 C15orf56 2 CCDC90A 2 COL21A1 2 DNAH11 3 ZNF513 2 ARHGEF37 2 C16orf55 2 CCNA1 2 COL3A1 2 DNAH17 3 ZNF554 2 ARHGEF7 2 C16orf78 2 CCNDBP1 2 COL8A2 2 DNAJB14 3 ZNF596 2 ARL5C 2 C16orf86 2 CCT2 2 COMMD10 2 DNAJB2 3 ZNF609 2 ARL9 2 Cl7orfl07 2 CD101 2COMMD3 2 DNAJB5 3 ZNF703 2ARMC4 2 C17orf59 2 CD163L1 2COMMD6 2 DNAJC18 3 ZNF704 2 ARMCX2 2 C17orf79 2 CD19 2COMP 2 DNAJC2 3 ZNF706 2 ASB6 2 C18orf63 2 CD248 2COPG1 2DNM1 3 ZXDB 2 ASCC1 2 C19orf24 2 CD300A 2 COX6C 2 DNMBP 2AAMP 2 ASCL4 2 C19orf57 2 CD300LB 2 CPA3 2 DNTTIP1 2 AASDH 2 ASNS 2 C1QTNF1 2 CD34 2 CPVL 2 DNTTIP2 2 ABCA17P 2 ASPA 2 Clorf105 2 CD3G 2 CRB1 2 DOCK11 2 ABCA3 2 ASXL2 2 Clorf151-NBL1 2 CD81 2 CRB2 2 DOCK3 2 ABL1 2 ATAD3A 2 Clorf172 2 CDC42BPG 2 CREB3L2 2 DPM2 2 ABLIM1 2 ATF5 2 Clorf213 2 CDC42EP5 2 CRELD1 2 DPP4 2ACADM 2 ATP10D 2 C1orf229 2 CDCP1 2 CRHBP 2 DPYS 2 ACBD4 2 ATP12A 2 C1orf233 2 CDH15 2 CRISPLD1 2 DPYSL2 2ACD 2 ATP13A1 2 Clorf53 2 CDH4 2 CRYBA2 2 DPYSL5 2 ACOT8 2 ATP1A1OS 2 C20orf94 2 CDS1 2 CRYBA4 2DRG1 2 ACSF2 2 ATP2B2 2 C21orf128 2 CEACAM4 2 CRYBB1 2 DSCR3 2 ACSL6 2 ATP4A 2 C21orf7 2 CENPB 2 CSK 2 DSCR9 2 ACTR1A 2 ATP6AP2 2 C22orf32 2 CENPN 2 CSNK2B 2 DSTN 2 ACTR8 2 ATP6V1E2 2 C22orf39 2 CEP76 2 CSPG4 2 DTNBP1

2 DTX3 2 FAM26D 2 GLTSCR2 2 HMGA1 2 KLHDC9 2 LOC100505761 2 DTYMK 2 FAM26E 2 GLYR1 2 HMGB3P1 2 KLHL12 2 LOC100505933 2 DUS1L 2 FAM45B 2 GMCL1 2 HMSD 2 KLHL15 2 LOC100507433 2 DYNLRB2 2 FAM47E 2 GMIP 2 HN1 2 KLHL2 2 LOC100507557 2 DYNLT3 2 FAM69A 2 GNAQ 2 HNF1B 2 KLHL33 2 LOC100508120 2 DYRK1B 2 FAM89A 2 GNAT1 2 HNRNPAO 2 KLHL35 2 LOC100652739 2 EARS2 2 FARSA 2GNG12 2 HOMER2 2 KLK2 2 LOC100652791 2 EB13 2 FBL 2 GNMT 2 HORMAD2 2 KLK8 2 LOC148709 2 ECHS1 2 FBLN1 2 GNPTAB 2 HOXB-AS5 2 KLK9 2 LOC149086 2 EDN3 2 FBP1 2 GOLGA3 2 HOXC9 2 KPNA5 2 LOC151174 2 EEF1A2 2 FBXL4 2 GOLGA7B 2 HOXD4 2 KPNA6 2 LOC154449 2EFCAB2 2FBXL5 2GOLGA8B 2 HPS1 2KRBA2 2LOC158435 2 EFNA4 2 FBXO22 2 GON4L 2 HSD17B1O 2 KREMEN1 2 LOC202181 2 EFNB1 2 FBXO34 2 GPANK1 2 HSD17B13 2 KRT15 2 LOC254099 2 EGFL6 2 FBXO39 2 GPI 2 HSD17B8 2 KRT25 2 LOC256880 2 EHF 2 FCRL5 2GPR113 2 HSD52 2 KRTAP5-8 2 LOC283335 2 EIF2AK1 2 FEV 2 GPR125 2 HSPA12B 2 KTN1 2 LOC284412 2 EIF2C4 2 FGF9 2 GPR144 2 HSPA9 2 KTN1-AS1 2 LOC284889 2 EIF2S2 2 FGFR2 2 GPR162 2 HTRA4 2 KYNU 2 LOC284950 2 EIF4A2 2 FGGY 2 GPR19 2 HVCN1 2 LACE1 2 LOC285033 2 EIF4E3 2 FHAD1 2 GPRIN3 2 IBSP 2LAMTOR5 2 LOC285484 2 EIF4H 2 FILIP1L 2 GPT 2IBTK 2 LARP4 2 LOC286189 2 ELF3 2 FIS1 2 GRAMD1B 2IGF2 2 LARP4B 2 LOC286190 2 ELK1 2 FLJ12334 2 GRAP 2IGF2BP3 2 LBH 2 LOC338817 2 ELL2 2 FLJ12825 2 GRB14 2IGLON5 2 LCE3A 2 LOC400558 2 ELMO3 2 FLJ14107 2 GRB2 2IKBKE 2 LCLAT1 2 LOC400927 2 ELOVL3 2 FLJ37453 2 GREB1 2IKZF3 2 LCN10 2 LOC402160 2EMB 2 FLOT2 2 GRID1 2 ILlRAP 2 LEKR1 2 LOC440600 2 EMID2 2 FLVCR1 2 GRIK1 2 ILlRL2 2LENG9 2 LOC554223 2ENDOD1 2 FLVCR1-AS1 2 GSC 2 IL6R 2 LEP 2 LOC643387 2 ENGASE 2 FLYWCH1 2 GTDC2 2 IMMT 2 LEPROTL1 2 LOC646626 2 ENPP6 2 FMNL2 2 GTF21RD1P1 IMPACT 2 LETM1 2 LOC646903 2ENPP7 2FN3K 2GTF3C5 21NE2 2LGALS9B 2LOC728024 2ENTPD2 2FN3KRP 2GTPBP4 21NHA 2LHFPL2 2LOC728558 2 ENTPD4 2 FOLR1 2 GUCA1C 2INHBA 2 LIG3 2 LOC729059 2EOGT 2FOS 2 GUCY1A2 2 INHBA-AS1 2 LIMAl 2 LOC729506 2 EPC1 2 FOSL1 2 GUCY1B3 2 INIP 2 LINCO0051 2 LOC729609 2 EPHAl 2 FOXD4L5 2 H2AFY 2 INS-IGF2 2 LINCO0092 2 LOC729732 2 EPHA2 2 FOXE3 2 H2AFY2 21QCC 2 LINCO0189 2 LOC729966 2 EPHB1 2 FOX11 2 HADHA 2IRX4 2 LINCO0307 2 LOC84989 2 EPM2A 2 FOXS1 2 HADHB 2ISCAl 2 LINC00346 2 LOC91450 2 EPS8L1 2 FPR3 2 HAUS4 2 ITCH 2 LINC00467 2 LOH12CR2 2 EPT1 2 FRS2 2 HAUS7 2 ITGB7 2 LINC00469 2LOX 2 ERAS 2 FSCN2 2 HCAR3 2ITPA 2 LINC00488 2 LOXL4 2 ERCC4 2 FSTL4 2 HCFC1 2JOSD1 2 LINCO0605 2 LPP-AS2 2 EREG 2 FUBP1 2HCG4 2JPH2 2 LINCO0620 2 LPXN 2 ERN1 2 FUT2 2HCG9 2 KANSL1L 2 LINC00638 2 LRP11 2 ESR2 2 FYN 2 HDLBP 2 KAT6A 2 LINC00642 2 LRR1 2 EV12A 2 FZD8 2 HEATR6 2 KCNA5 2 LINCO0654 2 LRRC25 2 EXOSC10 2 GABRR1 2 HEATR8 2 KCNC4 2 LIPE 2 LRRC30 2 EXOSC4 2 GAL3ST3 2 HEATR8-TTC4 2 KCNE3 2 LIPN 2 LRRC37A6P 2 EYA2 2 GALM 2 HEPACAM 2 KCNH1 2 LLGL2 2 LRRC40 2F3 2GALNT8 2 HERC1 2KCNJ1 2LMNB1 2LRRC55 2 FABP6 2 GALNTL2 2 HES6 2 KCNJ3 2 LNX1 2LRRC6 2 FAF2 2 GALNTL4 2 HEXA 2 KCNK15 2 LNX1-AS1 2LRRCC1 2 FAM105B 2 GAS2L1 2 HEXA-AS1 2 KCNK9 2 LOC100128593 2LRRTM4 2 FAM114A1 2 GAS2L3 2 HEY1 2 KDM3B 2 LOC100129858 2 LTBP1 2 FAM118A 2 GBE1 2 HINFP 2 KDM8 2 LOC100129924 2 LTN1 2 FAM123B 2 GBX2 2 HIP1R 2 KIAA0586 2 LOC100130238 2 LY6G5B 2 FAM124B 2 GCSAM 2 HIST1H2AC 2 KIAA1586 2 LOC100130700 2 LYN 2 FAM129A 2 GDF5 2 HIST1H2AL 2 KIAA1609 2 LOC100131635 2 LYPD3 2 FAM131C 2 GDPD2 2 HIST1H2BC 2 KIAA1755 2 LOC100134868 2 MAB21L3 2 FAM155B 2 GET4 2 HIST1H2BF 2 KIF12 2 LOC100268168 2 MAD2L2 2 FAM185A 2 GINS2 2 HIST1H2BK 2 KIF25 2 LOC100288974 2 MAG13 2 FAM186A 2 GINS3 2 HIST1H41 2 KIRREL 2 LOC100289019 2 MAMDC4 2 FAM196A 2 GIPC2 2 HLA-C 2 KL 2 LOC100289511 2 MAML2 2 FAM19A3 2 GK5 2 HLA-DQB1 2 KLB 2 LOC100505666 2 MAP2K1 2 FAM19A5 2 GLT8D2 2 HLA-DRB6 2 KLF16 2 LOC100505738 2 MAP2K4P1

2 MAP3K8 2 MIR4736 2 NEFH 2 PCDHB10 2 PPP1R14A 2 RD3 2 MAP6D1 2 MIR4749 2 NEK4 2 PCDHB3 2 PPP1R14B 2 REC8 2 MAPK1 2 MIR4751 2 NEK7 2 PCNXL3 2 PPP1R15A 2 RFX2 2 MAPK6 2 MIR4761 2 NENF 2 PCYT1B 2 PPP1R37 2 RFX8 2 MAPK7 2 MIR4779 2 NEO1 2 PCYT2 2 PPP1R3F 2 RGS5 2 MAPK81P2 2 MIR4786 2 NFE2 2 PDCD1 2 PPP2CB 2 RHBDF2 2 MAPRE2 2 MIR503 2 NHLRC2 2 PDCL2 2 PPP5C 2 RHOD 2 MARCH11 2 MIR5188 2 NHP2L1 2 PDE7A 2 PPP6R1 2 RIMS4 2 MBD6 2 MIR54802 2 NINJ1 2 PDSS1 2 PQLC2 2 RLBP1 2 MBL1P 2 MIR5702 2 NKAIN1 2 PDZK1IP1 2 PRAF2 2 RNASEH2B 2 MBNL2 2 MIR608 2 NLGN4Y 2 PEF1 2 PRDM11 2 RNF126P1 2 MCMBP 2 MKRN1 2 NME1-NME2 2 PEL12 2 PRF1 2 RNF144A 2 MCTP1 2 MKRN3 2 NME2 2 PEX7 2PRHOXNB 2 RNF150 2 MDH2 2 MLLT6 2 NOL12 2 PFDN5 2 PRKCE 2 RNF168 2 ME3 2 MMAB 2 NPAS2 2 PFKFB4 2 PRLHR 2 RNF208 2 MECOM 2 MMEL1 2 NPDC1 2 PFKP 2 PROP1 2 RNF224 2 MED12 2 MMP23B 2 NPFFR1 2 PFN2 2 PRPF40B 2 RNF7 2 MED22 2 MOCOS 2 NPHS2 2PGF 2 PRRG1 2 ROBO3 2 MED7 2 MORN2 2 NPPA-AS1 2PGM3 2 PRSS23 2 RPL11 2 MEF2D 2 MORN4 2 NPSR1 2 PHF20 2 PRSS33 2 RPL13A 2 MEIS2 2 MOS 2 NPTXR 2 PHGR1 2 PRTG 2 RPL13AP5 2 MEIS3 2 MPP5 2 NR4A2 2 PHOSPHOl 2PRUNE 2 RPL26L1 2 MEPCE 2 MRPL35 2 NRBP1 2 PHPT1 2 PSMB8 2 RPL3L 2 METTL24 2 MRPL48 2 NRN1L 2 PHYHD1 2 PSMC2 2 RPL4 2 METTL2A 2 MRPL9 2 NTN1 2 P14KB 2 PSMD12 2 RPL5 2 MFHAS1 2 MSL3 2 NTNG1 2 PIAS2 2 PSMD8 2 RPL7A 2 MFSD3 2 MSRB2 2 NTSR1 2 PIGC 2 PSMF1 2 RPS10 2 MGAT5B 2 MT2A 2 NUAK2 2 PIGU 2 PTCHD2 2 RPS1O-NUDT3 2 MGC23284 2 MTERF 2 NUDT21 2 PIK3R5 2 PTDSS1 2 RPS18 2 MIB2 2 MTERFD1 2 NUP35 2 PKD1L1 2 PTGER1 2 RPS24 2 MIR1182 2 MTMR6 2 NUP62 2 PKD1L2 2 PTGES3L 2 RPS8 2 MIR1184-1 2 MUC21 2 NUPR1L 2 PKDCC 2 PTGES3L- 2 RPUSD1 2 MIR1184-2 2 MULl 2 NUTF2 2 PKMYT1 AARSD1 2 RRM2B 2 MIR1184-3 2 MVK 2 NXF4 2 PLA2G2D 2 PTK2B 2 RSAD2 2 MIR1245A 2 MX1 2 03FAR1 2 PLA2G4A 2 PTOV1 2 RTN4RL1 2 MIR1248 2 MYBPHL 2 OAZ1 2 PLAC9 2 PTOV1-AS1 2 RTP2 2 MIR1284 2 MYCBPAP 2 OAZ3 2 PLBD1 2 PTP4A3 2 RUNDC1 2 MIR135A1 2 MYH16 2 OBSL1 2 PLBD2 2 PTPN11 2 RUNX1-IT1 2 MIR143 2 MYH6 2 OCLN 2 PLCB3 2 PTPN2 2 RWDD2A 2 MIR181C 2 MYLK 2 ODF3L1 2 PLCE1 2 PTPN22 2 RXRB 2 MIR181D 2 MYO5A 2 OGFOD1 2 PLCH2 2 PUS7 2 RXRG 2 MIR199B 2 MYO9A 2 OGFRL1 2 PLEKHN1 2 PVR 2 RYBP 2 MIR200B 2 MYOCD 2 OLIG1 2 PLK2 2 PVRL1 2 SAC3D1 2 MIR205 2 MYOZ1 2 OR10H2 2 PLLP 2 PYCR2 2 SAMD3 2 MIR205HG 2 NAA10 2 OR2T12 2 PLN 2 PYROXD1 2 SASS6 2 MIR208A 2 NACA 2 OXSR1 2 PLS3 2 R3HDML 2 SATB1 2 MIR21 2 NADKD1 2 OXTR 2 PLSCR3 2 RAB20 2 SCAMP4 2 MIR2276 2 NALCN-AS1 2 P2RX5 2 PLXDC1 2 RAB3A 2 SCAND3 2 MIR3154 2NANOGNB 2 P2RX5- 2 PM20D1 2 RAB9B 2 SCGB1D2 2 MIR339 2 NANOS3 TAX1BP3 2 PMAIP1 2 RABEP1 2 SCML2 2 MIR3646 2 NARFL 2 P2RY11 2PMVK 2 RAD51AP2 2SCOC 2 MIR3675 2 NAT8B 2 P2RY12 2 PNLIPRP2 2 RAD9B 2 SCUBE1 2 MIR3913-2 2 NBL1 2 PABPN1L 2 POC5 2 RALGDS 2 SDAD1 2 MIR3944 2 NBN 2 PAK6 2 POLN 2 RAPGEF4 2 SDC2 2 MIR424 2 NBPF3 2 PAMR1 2 POLR3A 2 RARRES2 2 SDK2 2 MIR4258 2 NCKAP1L 2 PANK2 2 POLR3B 2 RASAL2 2 SDS 2 MIR4284 2 NCOA5 2 PAPD7 2 PON 2 RASAL2-AS1 2 SDSL 2 MIR4316 2 NCOA7 2PAQR8 2 POU4F1-AS1 2 RASEF 2 SEC11C 2 MIR4458 2 NCR3 2 PARD6A 2 POU6F1 2 RASGRP4 2 SEC22B 2 MIR4479 2NDN 2 PARD6B 2 POU6F2 2 RASL1OB 2 SEC31A 2 MIR4499 2 NDNL2 2 PARD6G-AS1 2 PPAPDC1B 2 RBM12B 2 SEMA3E 2 MIR4508 2 NDUFA3 2 PARL 2 PPARG 2 RBM15 2 SEMA4A 2 MIR4513 2 NDUFA4 2 PAX1 2 PPARGC1B 2 RBM17 2 SEMA4G 2 MIR4656 2 NDUFB10 2 PAX9 2 PPBPP2 2 RBM26 2 SENP8 2 MIR4667 2 NDUFB2 2 PBX3 2 PPILl 2 RBM28 2 SEPT6 2 MIR4686 2 NDUFB2-AS1 2 PCBP1 2 PPIL2 2 RBMS2 2 SERGEF 2 MIR4707 2 NDUFB8 2 PCBP1-AS1 2 PPM1E 2 RBMX 2 SERINC5 2 MIR4726 2 NDUFS5 2 PCDH20 2 PPM1J 2 RCC2 2 SERPINF2

2 SERPING1 2SNHG6 2 TARBP1 2 TNNT1 2 VPS29 2 ZNF630 2 SERTAD4 2 SNORA74A 2 TARP 2 TNR 2 VPS45 2 ZNF642 2 SERTAD4-AS1 2 SNORA81 2 TBC1D12 2 TNRC6C 2 VPS52 2 ZNF670 2 SETMAR 2 SNORD105B 2 TBC1D24 2 TOM1L2 2 VSTM2L ZNF695 2 SGK494 2 SNORD16 2 TBCA 2 TP53 2 VT11B 2 ZNF671 2 SGSH 2 SNORD18A 2 TBL1X 2 TP53111 2 VWA2 2 ZNF687 2 SH3BGRL3 2 SNORD18B 2 TBX1 2 TP53113 2 VWC2 2 ZNF695 2 SHC1 2 SNORD18C 2 TBX15 2 TPBGL 2 WBP11P1 2 ZNF708 2 SHISA9 2 SNORD2 2 TBX3 2 TPK1 2 WDR5B 2 ZNF75A 2 SIGLEC17P 2 SNORD24 2 TBX5 2 TPST2 2 WDR85 2 ZNF783 2 SIRPA 2 SNORD32A 2 TBXAS1 2 TRA2A 2 WFDC3 2 ZNF790 2 SIRPB1 2 SNORD33 2 TCEAL7 2 TRAK2 2 WFDC5 2 ZNF827 2 SIRT2 2 SNORD34 2 TCF12 2 TRAM1 2 WHSC1L1 2 ZNRF3 2 SIRT6 2 SNORD35A 2 TCF7L2 2 TRH 2 WIPF2 2 ZPBP2 2 SIX4 2 SNORD36A 2 TDH 2 TRIB1 2 WISP2 2 ZRSR2 2 SIX5 2 SNORD36B 2 TEFM 2 TRIB3 2 WNT11 2 ZSCAN12P1 2 SKAP2 2 SNORD36C 2 TENC1 2 TRIM40 2 WNT6 2 ZSWIM6 2 SKIV2L2 2 SNORD38A 2 TESK1 2 TRIM44 2 WRAP53 2 ZUFSP 2 SLC12A5 2 SNORD38B 2 TESPAl 2 TRIM67 2 WRB 2 ZWILCH 2 SLC12A8 2 SNORD46 2 TET2 2 TRIM69 2 WWP2 1 AACSP1 2 SLC16A12 2 SNORD55 2 TEX2 2 TRIP10 2 XKR5 1 AANAT 2 SLC19A2 2 SNORD61 2 TGFBR3 2 TRMT1GB 2 XPA 1 ABCC4 2 SLC22A1 2 SNORD84 2 TGIF1 2 TRMT13 2 XRCC2 1 ABCC8 2 SLC22A23 2 SNORD87 2TH 2 TRPA1 2 YAE1Dl 1 ABHD10 2 SLC23A3 2 SNX21 2 THNSL2 2 TRPC6 2 YAF2 1 ABHD12B 2 SLC25A10 2 SNX9 2 THPO 2 TSC1 2 YlF1A 1 ABL2 2 SLC25A34 2 SORCS1 2 THRA 2 TSC22D3 2 YIPF4 1ACADVL 2SLC25A51 2SOS1 2 THSD4 2 TSLP 2YPEL2 1ACAP2 2 SLC26A5 2 SPAG5-AS1 2 TIGD2 2 TSPAN1 2 YWHAG 1 ACOX1 2 SLC27A5 2 SPATA20 2 TIGD7 2 TSPAN2 2 YY1AP1 1 ACOX2 2 SLC29A3 2 SPATA22 2 TIMM21 2 TSPAN4 2 ZBED6 1 ACP5 2 SLC2A10 2 SPEF1 2 TIMM44 2 TSPAN6 2 ZBP1 1 ACPP 2 SLC2A2 2 SPHK1 2 TIMM9 2 TSPEAR 2 ZBTB40 1 ACSL3 2 SLC30A10 2 SPIB 2 TJP1 2 TSPO2 2 ZBTB41 1 ACSL4 2SLC30A5 2SRRM3 2 TM4SF5 2TTC12 2ZBTB45 1ACTBL2 2SLC34A3 2SRSF11 2 TM9SF4 2TTC14 2ZC2HC1C 1ACTG1 2SLC35D2 2SRSF12 2 TMC7 2TTC17 2ZCCHC6 1ACTL6B 2 SLC35E2 2 SSC5D 2 TMED1 2 TTC32 2ZCWPW1 1ACTR3 2SLC35E4 2ST7 2 TMED9 2TUBGCP3 2ZDHHC2 1ACTR3C 2 SLC36A3 2 ST7-AS1 2 TMEM104 2 TXN2 2 ZDHHC23 1 ADAM12 2 SLC38A5 2 ST7-OT4 2 TMEM106C 2TXNDC5 2 ZDHHC8P1 1 ADAMTS13 2 SLC39A7 2 ST8SIA4 2 TMEM120B 2 TXNL4A 2 ZFP41 1 ADAMTS15 2 SLC41A3 2 STARD7 2 TMEM132B 2 U2AF1L4 2 ZFP91 1 ADCK4 2 SLC43A1 2 STAT5B 2 TMEM134 2 UBC 2 ZFP91-CNTF 1ADM 2 SLC44A3 2 STEAP1B 2 TMEM138 2 UBE2G1 2 ZFYVE27 1ADM2 2 SLC46A2 2 STK111P 2 TMEM145 2 UBE21 2 ZIK1 1 ADPGK-AS1 2 SLC46A3 2 STOX2 2 TMEM168 2 UBE2N 2 ZKSCAN1 1 AGTPBP1 2 SLC4A1AP 2 STRADB 2 TMEM170A 2 UBFD1 2ZKSCAN4 1 AGTR2 2 SLC5A7 2 STX7 2 TMEM178B 2 UBN1 2 ZMAT4 1 AIML 2 SLC6A15 2 STXBP5-AS1 2 TMEM179B 2 UBXN10 2 ZNF135 1 AIM2 2 SLC7A10 2 STYXL1 2 TMEM180 2 UGP2 2 ZNF137P 1 AKAP8 2 SLC7A2 2 SULT1C4 2 TMEM184B 2 ULK3 2 ZNF140 1 AKIRIN1 2 SLCO2B1 2 SULT2B1 2 TMEM194B 2 UNC5CL 2 ZNF167 1 ALAD 2SMAGP 2 SUN2 2TMEM2 2 UPK3B 2 ZNF17 1 ALAS1 2 SMARCAl 2 SUPT7L 2 TMEM200A 2URGCP 2 ZNF184 1ALDH3B2 2SMARCB1 2SYCE3 2 TMEM211 2 URGCP- 2ZNF202 1ALG1 2 SMARCD2 2 SYNDIG1 2 TMEM230 MRPS24 2 ZNF266 1 ALK 2SMG8 2SYNPO2L 2TMEM38B 2USP6NL 2ZNF268 1ALKBH7 2 SMOC1 2 SYT11 2 TMEM62 2 USP8 2 ZNF37BP 1 ALLC 2 SMPD3 2 SYT5 2 TMEM71 2 UTF1 2 ZNF416 1 ALPI 2 SMURF2 2 SYT6 2 TMEM74B 2 UTS2R 2 ZNF436 1 ALX4 2 SMYD5 2 SYT9 2TMOD2 2 VANGL1 2 ZNF469 1 AMBRAl 2 SNA12 2 SZRD1 2TMOD3 2 VAX1 2 ZNF487P 1 AMOT 2 SNA13 2 TAAR6 2 TMPRSS12 2 VCAM1 2 ZNF511 1 AMTN 2 SNAP91 2 TACC2 2 TMSB4Y 2 VCPIP1 2 ZNF518B 1 ANAPC13 2 SNAR-G1 2 TACSTD2 2 TNFAIP3 2 VMP1 2 ZNF540 1 ANAPClP1 2 SNAR-G2 2 TAF6L 2 TNFSF13B 2 VNN1 2 ZNF594 1 ANKDDlA 2SNHG4 2 TANC1 2 TNFSF14 2 VNN2 2 ZNF605 1 ANKDD1B

1 ANKRD10 1 C2orf8l 1 CLPTM1 1 EDN2 1 FOXR2 1 HERC2P2 1 ANKRD20A5P 1 C3orfl8 1 CNGA3 1 EEF2K 1 FSCN1 1 HFE 1 ANKRD53 1 C4orf29 1 CNPY1 1 EFCAB12 1 FSCN3 1 HFE2 1ANKRD6 1 C4orf32 1 CNRIP1 1 EFNA5 1 FSTL5 1 HHIP 1 ANKS1B 1 C5orf27 1 CNTN6 1 EFNB2 1 FTL 1 HHIP-AS1 1 ANXA2P2 1 C6orf62 1 COG1 1 EGR4 1 FUBP3 1 HIST1H1B 1 AP1G2 1 C6orf7 1 COL13A1 1 EIF2C3 1 FUCAl 1 HIST1H2BN 1 APOL1 1 C7orf23 1 COL1A2 1 ELMOD3 1FUNDC2 1 HIST1H4K 1 APOL2 1 C7orf49 1 COLEC11 1 ENAH 1FZD7 1 HIST2H2BF 1APRT 1 C7orf73 1 COMTD1 1 ENOX1 1 GAA 1 HIST4H4 1 AQP12B 1 C8orf37 1 COPS2 1 EPHX2 1 GABBR2 1 HMGA1P7 1AQPEP 1 C8orf74 1 CPOX 1 EPST11 1 GALNT6 1 HMGN4 1 ARF1 1 C9orfl29 1 CR1 1 ERP44 1 GALNT7 1 HNMT 1ARF5 1CA5BP1 1CRADD 1ESYT1 1GALNTL1 1 HNRNPUL1 1 ARFGEF2 1 CAB39L 1 CRIM1 1 ETS2 1GAPDHS 1 HOOK3 1 ARHGAP23 1 CACNA1E 1 CRY2 1 EXT1 1 GAS8 1 HOTTIP 1ARHGAP5 1 CALML4 1CRYGN 1 F2RL2 1 GATAD2B 1 HOXA13 1ARHGEF15 1CATSPER2P1 1CRYZ 1F5 1GBGT1 1 HOXA6 1 ARHGEF3 1 CBLN1 1 CSF2RB 1 FAM104B 1 GBP1 1 HOXD10 1 ARMC1 1 CBLN2 1 CSTA 1 FAM108A1 1 GCFC1 1 HPCAL4 1 ARMC7 1 CC2D1B 1 CTC1 1 FAM123A 1 GDF15 1 HPD 1 ARPP19 1 CCDC124 1 CTDP1 1 FAM129B 1 GDF7 1 HR 1 ARRB1 1 CCDC135 1 CTSA 1 FAM135A 1 GEM 1 HSD17B1 1ARSG 1 CCDC37 1 CX3CL1 1 FAM135B 1 GEMIN2 1 HSPA12A 1 ARX 1 CCDC48 1CXCR4 1 FAM157B 1 GGT5 1 HSPA14 1ASAH2B 1 CCDC60 1 CXorf48 1 FAM162B 1 GHRHR 1HSPBAP1 1 ASAP1-IT1 1 CCDC68 1 CYP26A1 1 FAM168A 1 GIGYF2 1 HTR5A 1 ASRGL1 1CCDC78 1 CYP39A1 1 FAM172BP 1 GIMAP2 1 HUWE1 1 ATF3 1 CCL 1 CYP4F8 1 FAM195B 1 GJD4 1 IDH2 1 ATG10 1 CCL8 1 CYTH2 1 FAM198A 1 GLIS3 1 IF127 1 ATP2B4 1 CCNY 1 DAP 1 FAM198B 1 GLRA4 1 IF144L 1ATP5C1 1 CCR2 1 DCDC1 1 FAM208B 1 GMPS 1 IF16 1 ATP5E 1 CCR7 1 DCHS2 1 FAM210B 1 GNB5 1 IGF2BP2 1 ATP6VOE1 1 CCR9 1 DCLK2 1 FAM211A 1 GPBAR1 1 IGFBP6 1ATP8B5P 1 CD109 1 DCLRE1C 1 FAM49A 1GPC4 1 IGFBP7 1 AVEN 1 CD160 1 DCUN1D3 1 FAM59A 1 GPC5 1 IGFN1 1 AVIL 1 CD164 1 DDX21 1 FAM72A 1 GPR126 1 IGSF21 1 B3GALNT2 1 CD209 1 DDX47 1 FAM76A 1 GPR156 1 IL12RB1 1 B3GALT4 1 CD86 1 DEFB121 1 FAM91A1 1 GPR180 1 ILlA 1 B4GALT2 1 CD8B 1DEFB133 1 FBXL13 1GPR62 1 IL1R 1 BAIAP2L1 1 CD9 1 DENND1B 1 FBXO10 1 GPR85 1 IL1R2 1 BBS7 1 CDC14A 1 DEPTOR 1 FBXO3 1GPR98 1 IL32 1 BCL2 1 CDCA4 1 DGKE 1 FBXO31 1GPX5 1 ILDR2 1 BEST2 1 CDH3 1 DHDH 1 FBXO36 1 GRAMD1C 1 IMMP2L 1 BLNK 1 CDK13 1 DHX36 1 FBXO9 1 GRHL3 1 IN080C 1BPHL 1 CDNF 1 D103 1 FBXW9 1 GRID2 1 INPP5K 1BYSL 1 CDX2 1 DIRC2 1 FEZF1 1 GRM1 1 INTS3 1 C12orf43 1 CDX4 1 DLGAP3 1 FEZF1-AS1 1 GRM7 1 IQCJ-SCHIP1 1 C12orf70 1 CEACAM5 1 DLL1 1 FFAR3 1 GSTA5 1 IQGAP2 1 C14orf23 1 CENPA 1 DNAJC24 1 FGA 1 GSTM3 1 ITGA8 1 C14orf93 1 CEP63 1 DNM2 1 FGF19 1 GTF2E2 1 ITGB4 1 C15orf54 1 CEP70 1 DNMBP-AS1 1 FGF20 1 GUCA2A 1 ITPKC 1 C16orf53 1 CETP 1 DPEP1 1 FGL1 1 GUSBP10 1 JMY 1 C16orf7l 1 CFB 1 DPF1 1 FIBP 1 GUSBP4 1 JPH4 1 C17orf67 1 CFTR 1 DPRXP4 1 FIGN 1 GYLTL1B 1 KANSL3 1 C18orf32 1 CHAT 1 DRD2 1 FIP1Ll 1 H2AFJ 1 KAT5 1 C1QL1 1 CHCHD5 1 DROSHA 1 FLJ21408 1 H3F3C 1 KBTBD7 1 C1QTNF9B- 1 CHERP 1 DSC3 1 FLJ33065 1 HAGHL 1 KCNA6 AS1 1 CHL1 1 DTNB 1 FLJ42351 1 HAVCR2 1 KCNA7 1 Clorf85 1 CHRM1 1 DUSP26 1 FMOD 1 HCG27 1 KCNJ4 1 Clorf94 1 CHRM4 1 DUSP28 1 FNBP1 1 HCRTR2 1 KCNJ9 1 C20orf160 1 CHRNG 1 E2F3 1 FNDC9 1 HCST 1 KCNMB1 1 C20orf166 1 CHST1 1 E2F4 1 FOLR2 1 HEATR5A 1 KCNQ3 1 C21orf49 1 CHUK 1 E2F5 1FOXD4 1 HECTD3 1 KCNS1 1 C21orf56 1 CIB3 1 EBF4 1 FOX12 1 HECTD4 1 KCNS3 1 C21orf62 1 CLDN11 1 ECH1 1 FOXO1 1 HELQ 1 KEL 1 C2orf43 1 CLINT1 1 EDC3 1FOXO3 1 HEMK1 1 KHDC1L 1 C2orf69 1 CLN6 1 EDIL3 1 FOXP3 1 HERC2P10 1 KIAA0232

1 KIAA1324 1 LOC440028 1 MIR55OA1 1 NUDT8 1 POR 1 RNASEH1 1 KIAA1430 1 LOC440461 1 MIR572 1 NUPL2 1 POSTN 1 RND3 1 KIF17 1 LOC442459 1 MIR802 1 NUSAP1 1 PPEF2 1 RNF112 1 KIFC3 1 LOC554206 1 MIR938 1 NWD1 1 PPIEL 1 RNF128 1 KIN 1 LOC643802 1 MIS18BP1 1 NXPH1 1 PPP1R12C 1 RNF135 1 KITLG 1 LOC646329 1 MITF 1 ODF3L2 1 PPP1R27 1 RNF14 1 KLHL32 1 LOC728218 1 MKNK2 1 OIP5 1 PPP1R35 1 RNF145 1 KLRC2 1 LOC728730 1 MN1 1 OIP5-AS1 1 PPP1R3C 1 RNF170 1 KNTC1 1 LOC729852 1 MOBP 1 OPN5 1 PPP1R9B 1 RNF5P1 1 KPNA4 1 LOC730102 1 MOG 1 OPRM1 1 PPP2R1A 1 ROPN1B 1 KRT12 1 LOC93622 1 MORC2-AS1 1 OR1Fl 1 PPP2R2B 1 RPA3 1KRT23 1LPHN3 1 MPP3 10R2J3 1PPP2R3A 1RPL8 1KRT73 1LPPR1 1 MPZL2 10R6K2 1PQLC3 1RPN1 1 KRTAP10-10 1 LRP2 1 MRAP2 1 OR7E2P 1 PRDM12 1 RRAS2 1 KRTAP10-6 1LRP2BP 1 MRAS 1 OSBPL10-AS1 1PRDX6 1 RRBP1 1 KRTAP2-2 1LRPAP1 1MRGPRG 1 OSGIN1 1 PREX1 1 RSAD1 1 KRTAP2-3 1 LRRC17 1 MRGPRX3 1 OTUD7B 1 PRICKLE2 1RSRC2 1 KRTAP5-5 1 LRRC23 1 MRO 1 P2RY13 1 PRICKLE2-AS1 1 RXFP3 1 KY 1 LRRC52 1 MRPL3 1 P2RY14 1 PRICKLE2-AS2 1 SAA1 1 LAMA3 1 LRRC61 1 MRPS10 1 PACSIN3 1 PRICKLE4 1 SAMD13 1 LAMP1 1LRRC8D 1 MRPS18C 1 PAK2 1 PRKCB 1 SAMD9L 1LCN2 1LTV1 1 MS4A4A 1PANK1 1PRKD1 1SAMM50 1 LCN6 1 LY6D 1 MSLN 1 PAPLN 1 PRPF39 1 SAT2 1 LGALS2 1 LYLl 1 MSRB3 1 PAQR7 1 PRR11 1SBSN 1 LGALS4 1 LYPD1 1 MSX1 1 PAX6 1 PRR3 1SBSPON 1LHFP 1LYPD5 1MSX2 1PCDH12 1PRRX1 1SCAI 1 LHFPL3-AS2 1 LYRM1 1 MTA1 1 PCED1B-AS1 1PSCA 1 SCG5 1LHX9 1 MACC 1MTG1 1PCK2 1PSEN1 1SCGB2A2 1 LILRA3 1 MAGED1 1 MTM1 1 PCYOX1L 1PSKH1 1 SCHIP1 1 LILRA6 1 MAP2K2 1 MTMR11 1 PDCD10 1 PSMB6 1 SDHAF1 1 LILRB5 1 MAP2K6 1 MTOR 1 PDIA3 1 PSMD13 1 SEC14L3 1 LIMD1 1 MAP6 1 MVP 1 PDK2 1 PTBP2 1 SEC16A 1 LINC00471 1 MARCH3 1 MYLl0 1 PDPN 1PTGER4 1 SEC22C 1 LINC00521 1 MARCH4 1 MYPOP 1 PEAl5 1PTGFR 1 SELL 1 LINC00617 1 MAST3 1 MYRIP 1 PEX13 1 PTGR1 1 SELO 1 LINC00673 1 MATN1 1 MYT1 1 PEX16 1 PTH1R 1 SELP 1 LINC00675 1 MATN1-AS1 1 NAALAD2 1 PFDN2 1 PTPN5 1 SEMA4C 1 LINGO2 1 MATN2 1NACAD 1 PFKL 1PTPRS 1SENP2 1LMO7 1 MATN3 1NADSYN1 1 PGPEP1 1PTPRT 1 SERINC1 1 LOC100127888 1 MCCD1 1 NAGPA 1 PHF17 1 PURA 1 SERPIN11 1 LOC100128264 1 MCM1o 1 NAGPA-AS1 1 PHF21A 1 RAB17 1SERTAD3 1 LOC100131067 1 MED13L 1 NANOS2 1 PHGDH 1 RAB8A 1 SEZ6 1 LOC100131138 1 MED20 1 NARS 1 PHKG1 1 RALB 1 SF3A3 1 LOC100131289 1 MEF2C 1 NCAPG2 1 PHOX2B 1 RAMP3 1 SF3B4 1 LOC100132078 1 MEIG1 1 NCCRP1 1 PHYH 1 RAP1GAP 1 SF3B5 1 LOC100272217 1 MEOX1 1 NDRG1 1 PIK3R3 1 RARRES3 1 SFXN2 1 LOC100288911 1 METTL20 1 NECAP2 1 PIM2 1 RASD1 1 SGK2 1 LOC100335030 1 METTL3 1 NEURL2 1 PINK 1 RASD2 1 SGPP2 1 LOC100422737 1 MFSD8 1 NF2 1 PITPNB 1 RASSF4 1 SH2D1A 1 LOC100505876 1 MGP 1 NFASC 1 PWIL4 1 RBBP9 1 SH3KBP1 1 LOC100506023 1 MICAL3 1 NFIB 1 PKIB 1 RC3H2 1 SHC2 1 LOC100506054 1 MIDlIP1 1 NFKBIA 1 PKM 1 RCAN3 1 SHC4 1 LOC100506388 1 MIOX 1 NFKBID 1 PLA2G2E 1 RCVRN 1 SHISA5 1 LOC100506804 1 MIPEP 1 NHLH2 1 PLA2G4C 1 RDM1 1 SHISA7 1 LOC100506810 1 MIR1207 1 NIT1 1 PLAT 1 RDX 1 SIAH1 1 LOC100616530 1 MIR1247 1 NKAIN2 1 PLAUR 1 REEP3 1 SIK1 1 LOC146513 1 MIR1250 1 NKPD1 1 PLEKHG4 1 REN 1 SIRPG 1 LOC150622 1 MIR1276 1 NLGN3 1 PLSCR4 1 RESP18 1 SIRT3 1 LOC221122 1 MIR133A2 1 NMNAT2 1 PLXNA4 1 RETSAT 1 SIX3 1 LOC254559 1 MIR135B 1 NR2F2 1 PMS2P4 1 REXO4 1 SKIDAl 1 LOC338963 1 MIR196A2 1 NR4A1 1 PNMT 1RFC3 1 SLC1OA3 1 LOC387647 1 MIR4269 1 NRARP 1 PNPO 1 RFTN2 1 SLC13A3 1 LOC387895 1 MIR4500HG 1 NRCAM 1 POF1B 1 RGCC 1 SLC17A3 1 LOC389906 1 MIR45OA2 1NRG2 1 POGLUT1 1 RHBDD2 1 SLC20Al 1 LOC399708 1 MIR4632 1 NRK 1 POLA1 1RHOA 1 SLC25A27 1 LOC400456 1 MIR4651 1 NRM 1 POLR21 1 RHOJ 1 SLC25A39 1 LOC401127 1 MIR4655 1 NTRK1 1 POLR3H 1 RIMKLA 1 SLC25A5 1 LOC439990 1 MIR548AE2 1 NUDT13 1 POM121LlOP 1 RNASE7 1 SLC25A5-AS1

1 SLC26A7 1 SPATA21 1 TBC1D8 1 TNN13K 1TUBA4A 1 WDR45L 1 SLC2A8 1 SPATS2 1 TBL1XR1 1TNRC6B 1TUBA4B 1 WDR54 1 SLC2A9 1 SPDEF 1 TBL2 1 TOMM6 1TUBB2B 1 WDR72 1 SLC35B1 1 SPG11 1 TBX10 1 TOP3B 1 TULP1 1 WNK4 1 SLC35G2 1 SPICE 1 TBX4 1 TOR2A 1 TXLNG 1 WNT7B 1 SLC37A3 1 SPINT1 1 TCAIM 1 TOX2 1 TXNRD1 1 XIRP1 1 SLC38A3 1 SPRY4 1 TCAP 1 TOX3 1 TYW3 1 ZBTB6 1 SLC38A4 1 SPTLC3 1 TCTA 1 TP5313 1 U2AF1 1ZCCHC8 1 SLC45A3 1 SS18L2 1 TEX33 1 TPD52 1 UBE2C 1ZCCHC9 1SLC45A4 1SSRP1 1TFAP2D 1TPGS1 1UBE2F 1ZDHHC13 1 SLC4A4 1 SSX4 1 THOC2 1 TP11 1 UBE2F-SCLY 1 ZDHHC20 1 SLC4A8 1 SSX4B 1 THOC7 1TPPP 1 UBE3B 1 ZNF107 1SLC4A9 1ST6GALNAC1 1THSD7B 1TPRX1 1UBL4A 1ZNF385D 1 SLC6A1 1 STAG3L4 1 TIMM17A 1TRABD2B 1 UBR5 1 ZNF394 1 SLC6A1-AS1 1 STAMBPL1 1 TM4SF1 1 TRAP 1 UCA1 1 ZNF418 1 SLC6A18 1 STAP1 1 TMEM114 1 TRAK1 1 UGT2B4 1 ZNF445 1 SLC6A4 1 STARD4 1 TMEM132E 1TREX2 1 UNKL 1 ZNF485 1 SLCO2A1 1 STARD4-AS1 1 TMEM170B 1 TRIL 1 UROD 1 ZNF502 1 SLCO4C1 1 STK25 1 TMEM201 1 TRIM22 1 USH1C 1 ZNF541 1 SLFN13 1 STK40 1 TMEM229A 1 TRIM31 1 USP21 1 ZNF569 1 SMPDL3B 1 STXBP6 1 TMEM240 1 TRIM34 1 USP4 1 ZNF570 1 SNAP47 1 STYK1 1 TMEM30A 1 TRIM4 1 USP50 1 ZNF585B 1 SNAR-F 1 SULT1E1 1 TMEM31 1 TRIM59 1 UVSSA 1 ZNF608 1 SNCAIP 1 SUZ12 1 TMEM33 1 TRIM6-TRIM34 1 VAMP5 1 ZNF619 1 SNORD53 1 SVEP1 1 TMEM39A 1 TRIM8 1VARS 1 ZNF740 1 SNTB1 1SYNE3 1 TMEM41A 1 TRMU 1VASH2 1 ZNF776 1SNUPN 1SYT12 1 TMEM65 1 TRO 1VMA21 1ZNRF2P2 1SNX27 1SYT7 1TMEM67 1TRPC4AP 1VPS53 1ZSCAN5B 1SOD3 1TACC3 1TMEM98 1TSPAN18 1 VSX1 1ZXDA 1 SORT 1 TAF11 1 TMPRSS2 1TSTD1 1 VTRNA1-2 1 SOWAHA 1 TAF13 1 TMX1 1 TTBK1 1 VWA5B1 1 SOX17 1 TAF1B 1 TNFAIP8L2 1TTC30A 1 WASF2 1SPAG4 1TAPBPL 1 TNFRSF10C 1 TTF1 1 WDFY2 1 SPATA12 1TBC1D2 1 TNKS1BP1 1 TTTY14 1 WDR34

EXAMPLES

[0080] To further illustrate these embodiments, the following examples are provided. These examples are not intended to limit the scope of the claimed invention, which should be determined solely on the basis of the attached claims. Example 1

[0081] Semen samples were from the University of Utah tissue bank following informed consent according to IRB-approved protocols. Individuals were asked to adhere to general semen collection instructions, which included 2-5 days of abstinence prior to collection. Collected samples were mixed in a 1:1 ratio with Test Yolk Buffer (Irvine Scientific, Santa Ana, CA) and stored in liquid nitrogen prior to utilization herein. Control samples (n = 54) were collected from normozoospermic men with proven fertility. The majority of control samples were composed of whole ejaculate (n = 36), while 12 were prepared by density gradient centrifugation prior to cryopreservation, and the preparation was not recorded for 6 of the samples. In vitro fertilization (IVF) samples were selected from 292 IVF patients based on embryo quality and pregnancy outcome (see Table 4). Table 4: General composition of the study groups including semen parameters and IVF embryo quality.

Good Poor embryos, Poor embryos, embryos, not pregnant pregnant pregnant Mean Std. Mean Std. Mean Std. ANOVA P Dev. Dev. Dev. Male age 33.08 5.97 32.98 4.29 33.15 5.03 0.9913 Sperm concentration (M/ml) 58.58 62.78 69.31 77.13 76.26 71.60 0.4527 Progressively motile sperm (%) 45.00 20.15 42.64 18.29 43.44 24.86 0.8867 Female age 30.93 4.52 32.60 5.12 30.98 4.51 0.242 # eggs retrieved 14.07 5.91 10.47 4.13 12.98 4.72 0.0103 # MII eggs 12.09 5.15 8.87 3.89 11.29 3.83 0.0073 # eggs fertilized normally 10.74 4.82 7.23 3.33 9.26 4.00 0.0019 # embryos cryopreserved 4.21 3.10 0.26 1.16 0.81 1.55 <0.0001 % fertilized eggs level 2- 6-cell on 0.73 0.23 0.37 0.30 0.45 0.30 <0.0001 day 3 % fertilized eggs level 2- early 0.44 0.18 0.07 0.09 0.13 0.15 <0.0001 blast on day 5/6 # embryos transferred 2.04 0.55 2.17 0.80 2.34 0.53 0.0596

[0082] Couples presenting with moderate to severe female factor infertility, including advanced maternal age and severe endometriosis or polycystic ovarian syndrome, were excluded from the study. A total of 55 patients were selected based on a high blastulation rate and confirmed pregnancy. Seventy-two patients were selected that displayed generally poor embryogenesis. Of these, 42 achieved a pregnancy, and 30 did not. A separate experiment was performed on a subset of the samples from IVF patients. For samples that contained > 5 x 106 progressively motile sperm (n = 44), DNA methylation was assessed on the whole ejaculate, and separately a portion of the sample was purified using a 45%/90% discontinuous Isolate gradient, and the 90% fraction was also subjected to methylation analysis.

[0083] Table 5 illustrates the frequency of male factor infertility (defined as being below the WHO threshold in at least one of the semen parameters), female factor infertility, the presence of both male and female factors, and the designation of idiopathic infertility among both partners. Also displayed are the natures of the various mild female factors within each group of IVF patients. The frequencies of all factors are statistically similar between groups (p > 0.05 by chi-squared analysis). Table 5: Frequency of male and mild female factors in 127IVF patient-couples tested (no significant differences were observed between groups).

Factor Good Poor Poor embryogenesis, embryogenesis, embryogenesis, positive pregnancy (n=42) positive negative pregnancy pregnancy (n=31) (n=53) Male Factor Only 15 12 14 Female Factor Only 16 13 17 Male & Female Factor 16 3 6 Idiopathic (Unexplained) 6 3 5 Endometriosis 10 3 10 Diminished Ovarian Reserve 2 5 3 Polycystic Ovary Syndrome 8 3 3

Example 2

[0084] Sperm samples were thawed simultaneously and were subjected to a column-based DNA extraction protocol with sperm-specific modification to the DNeasy kit (Qiagen, Valencia, CA). Prior to DNA extraction, somatic cell lysis was performed by incubation in somatic cell lysis buffer (0.1% SDS, 0.5% Triton X-100 in DEPC H 2 0) for 20 minutes on ice to eliminate white blood cell contamination. Next, somatic cell lysis sperm were pelleted, and a visual inspection of each sample was performed to ensure the absence of all potentially contaminating cells before proceeding. Extracted sperm DNA was bisulfite converted with EZ-96 DNA Methylation-Gold kit (Zymo Research, Irvine, CA) according to the manufacturer's recommendations specifically for use with array platforms. Converted DNA was then delivered to the University of Utah Genomics Core Facility and hybridized to Infinium HumanMethylation450 BeadChip microarrays (Illumina) and analyzed according to Illumina protocols. Example 3

[0085] Following the hybridization protocol, as discussed above, arrays were scanned and p-values were generated for each CpG by using the minfi package (see Aryee MJ et al. Bioinformatics. 2014;30(10):1363-9, which is incorporated by reference herein in its entirety) to extract methylation levels (p-values), which were adjusted using SWAN normalization (see Maksimovic J et al. Genome biology. 2012;13(6):R44, which is incorporated by reference herein in its entirety). Statistical comparisons were made between: 1) all patients versus controls; and 2) IVF patients with good embryogenesis versus patients with poor embryogenesis. Hierarchical clustering was applied using Euclidean distance between methylation profiles. For the construction of discriminative models to differentiate IVF patient samples from fertile donor samples, and good from poor embryo-quality samples, two types of features were explored to describe each sample: the Euclidean distance between the sample and all other samples in the training set, and a subset of the individual CpG methylation values for each sample. In the latter case, to select the subset, the 500 most discriminative loci were first identified using a Wilcoxon rank sum test (i.e., the 500 loci with the lowest p-values).

[0086] All models were constructed (including feature selection steps) and evaluated using ten-fold cross validation. Briefly, the samples are split into 10 stratified folds (10 disjoint sets where the proportion of factor levels in each set approximates, as closely as possible, the proportion in the full dataset). Ten rounds of testing are conducted where, for each round, one of the ten folds is held out of the complete dataset as testing data and the remaining nine folds are used to train the model. After model training is complete, the held-out testing data is classified, and the number of true/false positives and true/false negatives is recorded. This is repeated for all ten folds of the data, such that every sample is tested (classified) exactly once, and every sample is unknown to the model that classifies it.

[0087] For GO analysis, genes were ranked by the number of differentially methylated CpGs (p < 0.05, Wilcoxon rank sum test). For grouping genes into differentially methylated and not differentially methylated sets, individual p-values were combined for the CpGs within the promoter region (+/- 5 kb) of each gene using Stouffer's method (see Stouffer SA et al. Adjustment during Army Life. Princeton:

Princeton University Press; 1949, which is incorporated by reference herein in its entirety). Unless otherwise stated, all p-values are corrected for multiple hypothesis testing using Benjamini and Hochberg's method (see Benjamini Y and Hochberg Y. Journal of the Royal Statistical Society, Series B. 1995;57(1):289-300, which is incorporated by reference herein in its entirety). Example 4

[0088] To establish a baseline for comparison, two non-informative models were used that make no use of the features in each sample: ZeroR and Random. The first of these, ZeroR, always predicts the majority class when classifying samples (the class which appears most often in the training data). The second, Random, assigns a class to each sample based on a Bernoulli trial with success probability of 0.5. Example 5

[0089] For classifying samples based on Euclidean distance to other samples, a decision stump classifier was used. Briefly, this is a rule of the form 'if distance is greater than X, classify the sample as class A else classify it as class B,' where A and B depend on the comparison (for example, good and poor embryo quality). The value of X is learned by exhaustive enumeration of discriminative thresholds, and the one with the lowest relative cost is selected. The trade-off between sensitivity and specificity was modulated in this learning process by adjusting the relative cost of false positives to false negatives. Example 6

[0090] For classifying samples based on the p-values from a subset of selected CpGs, the decision stump classifier, as described above, was used. More complex models and learning algorithms are also explored: a support vector machine (see Platt JC. Sequential Minimal Optimization: A Fast Algorithm for Training Support Vector Machines. Advances in kernel methods - support vector learning. 1998, which is incorporated by reference herein in its entirety), a nearest neighbor classifier, a decision tree, and naive Bayes; WEKA (see Hall M et al. The WEKA Data Mining Software: An Update. SIGKDD Explorations. 2009;11(1), which is incorporated by reference herein in its entirety) was used for its implementation of these, run with default parameters unless specified. Further, a number of these were augmented with adaptive boosting (AdaBoost), with bootstrap aggregating (bagging), and by weighting training data to effect a cost-sensitive training scheme (always favoring high specificity). Example 7

[0091] A hierarchical clustering of all 163 neat samples was performed, based on the methylation level of all 485,000+ CpGs interrogated by the array for each sample. This clustering (see FIG. 1A) revealed an out-group composed exclusively of IVF-patient samples (labeled in FIG. 1A as the patient-only cluster), which contained within it a sub group almost exclusively composed of samples which lead to poor embryo quality (labeled in FIG. 1A as the poor embryo-quality cluster). However, the majority of IVF patient samples and poor embryo-quality samples were distributed evenly amongst fertile donor samples and good embryo-quality samples outside of this group.

[0092] Without being bound by theory, the above results suggest two modalities of infertility: large-scale methylation aberrations that are identifiable at the full-genome resolution employed herein, and subtler methylation changes that might affect a smaller number of critical loci. To assess the predictive power of the genome-scale methylation differences observed from the clustering, a simple decision-stump classifier was trained (as described above) using ten-fold cross-validation wherein each sample was described by the Euclidean distance to each of the samples in the training set. The false positive cost of the training algorithm was adjusted (as described above) from 1 (i.e., a false positive was considered as costly as a false negative when training) to 10 (i.e., a false positive was considered 10 times more costly than a false negative when training). It was observed that with high false-positive costs, the classifier could achieve close to perfect specificity while identifying between a quarter and a third of the IVF-patient or poor embryo-quality samples (see FIGS. 1B and 1C).

[0093] The above-described analysis was replicated on the density gradient-purified samples, and an even more stark separation of good and poor embryo-quality samples was observed, although little discernible separation of IVF-patient and donor samples was observed, possibly due to the small number of purified donor samples (see FIG. 2A). This was reflected in the classification results from these samples, which showed even greater ability to identify poor embryo-quality samples, with just under half of the poor embryo-quality patients recovered with zero false positives, while the ability to differentiate between IVF-patient and donor samples was largely eliminated (see FIGS. 2B and 2C). Example 8

[0094] To assess whether differences in methylation between groups were concentrated at particular individual CpGs or regions, differentially methylated positions (DMPs) were called using a Wilcoxon rank-sum test. As a control, this was repeated with randomly shuffled sample labels. The number of differentially methylated CpGs identified between IVF-patient samples and donor samples (here neat samples were concentrated on, as these generally showed the greater signal), both before and after correction for multiple hypothesis testing is shown in FIG. 3A. The histogram of p-values from all CpGs is displayed in FIG. 3B, and shows a sharp spike in significant p-values for actual labels, with a relatively flat distribution for the shuffled control. The significant CpGs identified when using real labels showed no discernible bias towards particular genomic regions when compared to those from the randomly shuffled control (see FIG. 3C).

[0095] To estimate the reproducibility of the selection, the samples were broken into 10 groups of approximately equal size. For each group, the selection of DMPs was repeated with those samples held out. It was observed that the number of groups for which a CpG was selected in the top 100 most differentially methylated CpGs was generally low when using randomly shuffled labels. In contrast, when using real labels, this followed a U-shaped distribution, with a substantially larger proportion of CpGs always, or generally always, appearing in the top 100 (Table 6 gives the genes which are intersected by these consistently differentially methylated CpGs). The classifier training and evaluation, as described above, were repeated but herein only the top 50, 1,000, 50,000, or 400,000 differentially methylated CpGs were used in the training data to compute Euclidean distances. ROC curves for each are displayed in FIG. 3E, and show an advantage to classification when using fewer features. This was taken a step further by training a range of models using the raw methylation values for the selected CpGs as features (rather than Euclidean distance between samples). Using a bagged cost-sensitive support vector machine (as described above), IVF patient samples with a positive predictive value of 99% and a sensitivity of 82% were identified; ROC curves are shown in FIG. 3F. When the same approach was applied to the purified samples to identify differentially methylated CpGs, no significant CpGs were found after correction for multiple hypothesis testing (see FIG. 6A). Further, the distribution of p-values derived from the real and shuffled labels were largely identical (see FIG. 6B). Table 6: Genes that overlap CpGs consistently in the top 100 most differentially methylated CpGs when comparing unpurified donor and IVF patient samples.

Gene AHDC1 ALOX5AP BTBD17 CXXC11 EEF1A2 FBLN2 FGF18 GRM6 HIST1H4J HIST1H4K INPP5A JAG2 KCNQ1 KIAA0319L LRRC45 MIR4734 MLLT6 MTMR6 MXRA7 NCDN NDUFS6 NDUFS8

Gene OGFOD2 PSTPIP1 RAP1GAP2 SERPINF2 STRA13 SYT8 TCIRG1 TNNI2 USP24

[0096] As with the DMPs in the neat samples for fertility status, there was no bias towards particular regions; however, in contrast, there was also no tendency for any DMPs to consistently appear in the top 100 when using different selections of the data (see FIGS. 6C and 6D). When training distance-based classifiers as described above, it was observed that using more CpGs resulted in higher and more stable specificity and positive predictive value, while no discernible pattern in performance was apparent when attempting to use a reduced set of features (see FIG. 6E). Without being bound by theory, these results may suggest either large-scale whole-genome shifts in DNA methylation in poor embryo-quality samples, or more complex patterns that cannot be isolated by examining single CpGs. Example 9

[0097] To assess biological processes and pathways impacted by the observed changes in DNA methylation, genes were ranked by the number of CpGs that were identified as differentially methylated within their promoter regions (+/- 5 kb around TSS) and GO analysis was performed on the top 1,000 genes. In all cases (both purified and neat samples for IVF patient versus fertile donor samples, and good versus poor embryo quality samples) a significant enrichment for genes involved in cell adhesion, as well as other functions, was observed (see FIG. 4A and Table 7). Additionally, several gene families associated with embryogenesis and development are differentially methylated when comparing the good and poor embryogenesis groups.

Table 7

Embryo quality Embryo quality Source (IVF Source (IVF (good vs. poor) (good vs. poor) patient vs. patient vs. Purified Neat donor) donor) Purified Neat axon guidance NA 0.003784515 NA NA axonogenesis 0.008367064 1.10E-05 NA NA biological adhesion 1.36E-10 8.28E-07 6.41E-12 2.02E-11 cell adhesion 1.74E-10 1.20E-06 9.03E-12 3.86E-11 cell morphogenesis 0.008091845 1.14E-06 0.015385704 0.013289352 cell morphogenesis involved in differentiation 0.002429427 1.37E-06 0.015840977 0.013687946 cell morphogenesis involved in neuron differentiation 0.008267382 1.05E-05 NA 0.034601396 cell motion NA 0.024863785 NA NA cell part morphogenesis 0.037927527 6.36E-06 NA NA cell projection morphogenesis 0.02677415 3.52E-06 NA NA cell projection organization NA 1.02E-06 NA NA cell-cell adhesion 2.67E-11 9.53E-07 7.62E-12 2.61E-11 cellular component morphogenesis 0.008715713 3.86E-06 NA 0.039603502 digestive system development 0.02794709 NA NA NA digestive tract morphogenesis 0.02794709 NA NA NA embryonic morphogenesis 0.026568701 NA 0.014366035 NA embryonic skeletal system development NA NA 0.021136452 NA homophilic cell adhesion 8.48E-17 3.66E-06 4.22E-18 1.91E-18 induction of apoptosis by extracellular signals NA 0.023856862 NA NA intracellular signaling cascade NA 0.045548369 NA NA lung development 0.044371938 NA NA NA negative regulation of biosynthetic process NA NA 0.002233179 NA negative regulation of cellular biosynthetic process NA NA 0.001656261 NA negative regulation of gene expression 0.029000863 NA 0.002005071 NA negative regulation of macromolecule biosynthetic process NA NA 0.0062529 NA negative regulation of NA NA 0.01068737 NA

Embryo quality Embryo quality Source (IVF Source (IVF (good vs. poor) (good vs. poor) patient vs. patient vs. Purified Neat donor) donor) Purified Neat macromolecule metabolic process negative regulation of nitrogen compound metabolic process NA NA 0.008631708 NA negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process NA NA 0.007122006 NA negative regulation of RNA metabolic process 0.029592325 NA 0.006087709 0.033210106 negative regulation of transcription NA NA 0.004287172 NA negative regulation of transcription, DNA dependent 0.029393991 NA 0.005434563 0.028487512 neuron development 0.019683889 3.89E-06 NA 0.030918008 neuron differentiation 0.001351102 1.90E-05 NA NA neuron projection development NA 1.95E-05 NA NA neuron projection morphogenesis 0.018289937 3.82E-06 NA NA positive regulation of biosynthetic process NA NA 0.013869556 NA positive regulation of cellular biosynthetic process NA NA 0.011099844 NA positive regulation of gene expression NA NA 0.018166293 NA positive regulation of macromolecule biosynthetic process NA NA 0.006219076 NA positive regulation of macromolecule metabolic process NA NA 0.006136247 NA positive regulation of nitrogen compound metabolic process NA NA 0.008496523 NA positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process NA NA 0.006010823 NA positive regulation of RNA metabolic process NA NA 0.010851993 NA positive regulation of transcription NA NA 0.012919027 NA

Embryo quality Embryo quality Source (IVF Source (IVF (good vs. poor) (good vs. poor) patient vs. patient vs. Purified Neat donor) donor) Purified Neat positive regulation of transcription from RNA polymerase Il promoter NA NA 0.024169014 NA positive regulation of transcription, DNA dependent NA NA 0.009668106 NA regulation of generation of precursor metabolites and energy NA 0.014145172 NA NA regulation of Ras protein signal transduction 0.020126317 0.000569769 NA 0.001939159 regulation of Rho protein signal transduction NA 0.000342889 NA 0.01927069 regulation of small GTPase mediated signal transduction 0.000122766 0.000206064 0.002639504 3.01E-06 regulation of transcription from RNA polymerase Il promoter 0.01852138 NA 0.004058305 NA respiratory system development 0.026362859 NA NA NA skeletal system development 0.019027616 NA 0.020915396 NA skeletal system morphogenesis 0.015897973 NA NA NA

[0098] p-values within promoter regions for differential methylation between purified good and poor embryo-quality samples were combined to arrive at a single p-value for differential methylation of each gene. It was found that the set of differentially methylated genes identified in this way contained 25 imprinted genes, accounting for close to 10% of known imprinted genes. As a control, the labels on these samples were randomly permuted and the analysis was repeated; only one imprinted gene was identified as differentially methylated following permutation testing (see FIG. 4B).

Example 10

[0099] In predicting embryo quality, the analyses demonstrated that no individual CpG displayed significant differential methylation between the "good" and "poor" embryo groups after correcting for multiple comparisons. Predictive power was generally poor when models were trained based on a small number of CpGs. Generally, as the number of CpGs for the predictive models was increased, predictive power increased (see FIGS. 6A-6E). Without being bound by theory, this may suggest that while poor embryogenesis cannot be attributed to a few consistently altered CpGs, the genome wide methylation profile seems to be inherently different in men in the poor embryo group. Furthermore, when density gradient purified samples were assessed, the predictive power of good versus poor embryo quality was significantly improved. Without being bound by theory, a reason for this observation may be that the purification step reduced background methylation heterogeneity, thus improving the overall methylation signatures of the two groups.

[0100] In contrast to the above-described results, comparison of sperm methylomes between fertile men and IVF patients revealed more than 8,500 significantly differentially methylated CpGs after multiple comparison correction. The same strategy for predictive modeling as was employed to classify good versus poor embryo patients was employed. Herein, it was found that models were most effective at classifying samples when samples were classified using only the most significantly differentially methylated CpGs (see FIG. 3). Comparing controls with IVF patients, whole ejaculate was more effective at classifying samples than the evaluation of methylation in purified samples. Example 11

[0101] The genomic context of methylation alterations and the gene classes affected by differential methylation between groups were evaluated. There did not appear to be any enrichment for differential methylation within a specific genomic context (see FIGS. 3C and 6A-6E). Without being bound by theory, this may suggest that methylation perturbations associated with infertility may not be driven by CpG density or chromatin architecture. GO analysis indicated highly significant enrichment for several functional classes of genes (see FIG. 4). For example, as discussed above, genes involved in cellular adhesion were significantly over-represented among differentially methylated CpGs for all comparisons made. Genes involved in cellular morphogenesis and differentiation were also over-represented in the good versus poor embryogenesis comparison and to a lesser extent in the IVF versus fertile donor comparison. Furthermore, imprinted genes were significantly over-represented among the list of differentially methylated genes when comparing good versus poor embryogenesis samples. This enrichment was not detected when comparing IVF patients and fertile donors. Example 12

[0102] Hierarchical clustering of samples showed that, while there were differences between purified and unpurified samples, purified and unpurified methylomes derived from the same sample always, or generally always, clustered with each other; between sample differences were greater than between purification method differences (see FIGS. 5A and 5B). Example 13

[0103] A fertile reference methylome may be used to identify infertile samples. First, using the fertile reference methylome, aberrantly methylated CpGs can be identified as discussed above (i.e., more than 0.2 different from the maximum/minimum value observed in the reference). This can be done for infertile patient samples, as well as fertile controls (using hold-one-out cross-validation). Second, the number of times each CpG is found to be aberrantly methylated in infertile patients can be counted. Third, all CpGs can be ranked by the number of times they are differentially methylated in patients, and the top ten (10) CpGs can be selected as predictive of patient status. It need not be ten, but ten is the number used in the plot shown in FIG. 7 (described below).

[0104] Fourth, each sample can be given a score between 0 and 10, representing the number of CpGs from the above list which it has aberrantly methylated. Fifth, all of the samples can then be ranked by their score, and an ROC curve can be plotted (see FIG. 7; a "positive" here is considered to be a diagnosis of infertility).

[0105] As depicted in the ROC curve of FIG. 7, samples with high counts of loci showing aberrant methylation (relative to the reference) which are commonly seen in other known-infertile patient samples also tend to be patients themselves (and would be "diagnosed" as infertile using this approach).

[0106] It will be apparent to those having skill in the art that many changes may be made to the details of the above-described embodiments without departing from the underlying principles of the invention.

Claims (29)

Claims

1. A method of identifying a male fertility condition in a subject, comprising: extracting DNA from a semen sample from the subject; identifying a methylation pattern of the extracted DNA; comparing the methylation pattern of the extracted DNA to a control pattern of DNA methylation; and determining if the methylation pattern of the extracted DNA is different from the control pattern of DNA methylation, wherein the difference comprises aberrant methylation associated with the following genes: AHDC1, ALOX5AP, BTBD17, CXXC11, EEF1A2, FBLN2, FGF18, GRM6, HIST1H4J, HIST1H4K, INPP5A, JAG2, KCNQ1, KIAA0319L, LRRC45, MIR4734, MLLT6, MTMR6, MXRA7, NCDN, NDUFS6, NDUFS8, OGFOD2, PSTPIP1, RAP1GAP2, SERPINF2, STRA13, SYT8, TCIRG1, USP24, and TNN12, and wherein a different methylation pattern of the extracted DNA indicates that the subject has a male fertility condition.

2. The method of claim 1, wherein the control pattern of DNA methylation is a fertile reference methylome made by a method comprising: obtaining a plurality of sperm cell samples from fertile sperm donors; determining a fraction of sperm cells in each of the plurality of sperm cell samples that are methylated at each of two or more loci; and defining an expected range of methylation at each of the two or more loci based on the fraction of sperm cells in each of the plurality of sperm cell samples that are methylated at each of the two or more loci.

3. The method of claim 2, wherein the defining the expected range of methylation at each of the two or more loci further comprises: defining a maximum normal methylation level of each of the two or more loci; and defining a minimum normal methylation level of each of the two or more loci.

4. The method of claim 3, wherein the defining the maximum normal methylation level of each of the two or more loci comprises determining a highest remaining value of methylation at each of the two or more loci by discarding the highest "a" percent values of each of the two or more loci, and wherein the maximum normal methylation level at each of the two or more loci is the smaller of one (1) or "b" higher than the highest remaining value.

5. The method of claim 3, wherein the defining the minimum normal methylation level of each of the two or more loci comprises determining a smallest remaining value of methylation at each of the two or more loci by discarding the lowest "a" percent values of each of the two or more loci, and wherein the minimum normal methylation level at each of the two or more loci is the larger of zero (0) or "b" lower than the smallest remaining value.

6. The method of claim 4 or 5, wherein "a" is between about 2 and about 3 and "b" is between about 0.1 and about 0.3 or wherein "a" is about 2.5 and "b" is about 0.2.

7. The method of any one of claims 1-6, wherein the semen sample is a whole ejaculate semen sample.

8. The method of any one of claims 1-7, wherein the method identifies the male fertility condition with a positive predictive value of greater than 60%, 70%, 80%, or 90%.

9. The method of any one of claims 1-8, wherein the methylation pattern is a genome-wide methylation pattern.

10. The method of any one of claims 1-9, wherein the methylation pattern comprises a methylation status of at least 50,000 cytosine-guanine dinucleotides (CpGs) from the extracted DNA.

11. The method of any one of claims 1-10, wherein the methylation pattern comprises a methylation status of at least 50,000 cytosines from the extracted DNA.

12. The method of any one of claims 1-11, wherein the methylation pattern of the extracted DNA is identified by a method selected from at least one of a DNA methylation array, pyrosequencing, reduced representation bisulfite sequencing, targeted bisulfite sequencing, genome-wide bisulfite sequencing, bisulfite patch PCR, or a combination thereof.

13. The method of any one of claims 1-12, wherein the methylation pattern of the extracted DNA is identified by a method comprising: treating a portion of the extracted DNA with bisulfite; amplifying the bisulfite-treated DNA; hybridizing the amplified DNA to a DNA methylation array; and processing the hybridized DNA methylation array to determine the methylation pattern of the extracted DNA.

14. The method of any one of claims 1-13, further comprising: purifying the semen sample.

15. The method of claim 14, wherein the purification is via somatic cell lysis or via density gradient purification.

16. The method of any one of claims 1-15, wherein the subject is human.

17. A method of predicting in vitro fertilization (IVF) embryo quality, comprising: collecting a semen sample from a subject; extracting DNA from a portion of the semen sample; identifying a methylation pattern of the extracted DNA; comparing the methylation pattern of the extracted DNA to a control pattern of DNA methylation; and determining if the methylation pattern of the extracted DNA is different from the control pattern of DNA methylation, wherein the difference comprises aberrant methylation associated with the following genes: AHDC1, ALOX5AP, BTBD17, CXXC11, EEF1A2, FBLN2, FGF18, GRM6, HIST1H4J, HIST1H4K, INPP5A, JAG2, KCNQ1, KIAA0319L, LRRC45, MIR4734, MLLT6, MTMR6, MXRA7, NCDN, NDUFS6, NDUFS8, OGFOD2, PSTPIP1, RAP1GAP2, SERPINF2, STRA13, SYT8, TCIRG1, USP24, and TNN12, and wherein a different methylation pattern of the extracted DNA indicates that an embryo generated via fertilization with the semen sample is at risk of being a poor-qualityIVF embryo.

18. The method of claim 17, wherein the control pattern of DNA methylation is a fertile reference methylome made by a method comprising: obtaining a plurality of sperm cell samples from fertile sperm donors; determining a fraction of sperm cells in each of the plurality of sperm cell samples that are methylated at each of two or more loci; and defining an expected range of methylation at each of the two or more loci based on the fraction of sperm cells in each of the plurality of sperm cell samples that are methylated at each of the two or more loci.

19. The method of claim 18, wherein the defining the expected range of methylation at each of the two or more loci further comprises: defining a maximum normal methylation level of each of the two or more loci; and defining a minimum normal methylation level of each of the two or more loci.

20. The method of claim 19, wherein the defining the maximum normal methylation level of each of the two or more loci comprises determining a highest remaining value of methylation at each of the two or more loci by discarding the highest "a" percent values of each of the two or more loci, and wherein the maximum normal methylation level at each of the two or more loci is the smaller of one (1) or "b" higher than the highest remaining value.

21. The method of claim 19, wherein the defining the minimum normal methylation level of each of the two or more loci comprises determining a smallest remaining value of methylation at each of the two or more loci by discarding the lowest "a" percent values of each of the two or more loci, and wherein the minimum normal methylation level at each of the two or more loci is the larger of zero (0) or "b" lower than the smallest remaining value.

22. The method of claim 20 or 21, wherein "a" is between about 2 and about 3 and "b" is between about 0.1 and about 0.3 or wherein "a" is about 2.5 and "b" is about 0.2.

23. The method of any one of claims 17-22, wherein the semen sample is a whole ejaculate semen sample.

24. The method of any one of claims 17-23, wherein the method predicts embryo quality with a positive predictive value of greater than 60%, 70%, 80%, or 90%.

25. A method of making a fertile reference methylome, the method comprising: obtaining a plurality of sperm cell samples from fertile sperm donors; determining a fraction of sperm cells in each of the plurality of sperm cell samples that are methylated at the following genes: AHDC1, ALOX5AP, BTBD17, CXXC11, EEF1A2,FBLN2,FGF18,GRM6,HIST1H4J,HIST1H4K,INPP5A,JAG2,KCNQ1, KIAA0319L, LRRC45, MIR4734, MLLT6, MTMR6, MXRA7, NCDN, NDUFS6, NDUFS8, OGFOD2, PSTPIP1, RAP1GAP2, SERPINF2, STRA13, SYT8, TCIRG1, USP24, and TNN12; and defining an expected range of methylation at the following genes: AHDC1, ALOX5AP, BTBD17, CXXC11, EEF1A2, FBLN2, FGF18, GRM6, HIST1H4J, HIST1H4K, INPP5A, JAG2, KCNQ1, KIAA0319L, LRRC45, MIR4734, MLLT6, MTMR6, MXRA7, NCDN, NDUFS6, NDUFS8, OGFOD2, PSTPIP1, RAP1GAP2, SERPINF2, STRA13, SYT8, TCIRG1, USP24, and TNN12 based on the fraction of sperm cells in each of the plurality of sperm cell samples that are methylated at the following genes: AHDC1, ALOX5AP, BTBD17, CXXC11, EEF1A2, FBLN2, FGF18, GRM6, HIST1H4J, HIST1H4K, INPP5A, JAG2, KCNQ1, KIAA0319L, LRRC45, MIR4734, MLLT6, MTMR6, MXRA7, NCDN, NDUFS6, NDUFS8, OGFOD2, PSTPIP1, RAP1GAP2, SERPINF2, STRA13, SYT8, TCIRG1, USP24, and TNN12.

26. The method of claim 25, wherein the defining the expected range of methylation at each of the two or more loci further comprises: defining a maximum normal methylation level of each of the two or more loci; and defining a minimum normal methylation level of each of the two or more loci.

27. The method of claim 26, wherein the defining the maximum normal methylation level of each of the two or more loci comprises determining a highest remaining value of methylation at each of the two or more loci by discarding the highest "a" percent values of each of the two or more loci, and wherein the maximum normal methylation level at each of the two or more loci is the smaller of one (1) or "b" higher than the highest remaining value.

28. The method of claim 26, wherein the defining the minimum normal methylation level of each of the two or more loci comprises determining a smallest remaining value of methylation at each of the two or more loci by discarding the lowest "a" percent values of each of the two or more loci, and wherein the minimum normal methylation level at each of the two or more loci is the larger of zero (0) or "b" lower than the smallest remaining value.

29. The method of claim 27 or 28, wherein "a" is between about 2 and about 3 and "b" is between about 0.1 and about 0.3 or wherein "a" is about 2.5 and "b" is about 0.2.

The University of Utah Research Foundation

The University of Southern California Research Foundation

Episona, Inc.

Patent Attorneys for the Applicant/Nominated Person

SPRUSON&FERGUSON