AU2017223589B2 - Exogenous gene expression in therapeutic adenovirus for minimal impact on viral kinetics - Google Patents

Abstract

Recombinant adenovirus genomes that include an exogenous open reading frame (ORF) and a self-cleaving peptide coding sequence are described. Optimal placement of the exogenous genes for minimal impact on viral kinetics is further disclosed. Therapeutic applications of the recombinant adenoviruses are also described.

Description

EXOGENOUS GENE EXPRESSION IN THERAPEUTIC ADENOVIRUS FOR MINIMAL IMPACT ON VIRAL KINETICS

CROSS REFERENCE TO RELATED APPLICATIONS This application claims the benefit of U.S. Provisional Application No. 62/298,653, filed February 23, 2016, which is herein incorporated by reference in its entirety.

FIELD This disclosure concerns the optimal placement of exogenous open reading frames in recombinant adenovirus constructs and therapeutic applications of the recombinant viruses.

BACKGROUND Adenovirus serotype 5 (Ad5) is the vector of choice in basic research applications, murine lung cancer models, and human gene therapy trials. Adenoviruses have a stable 36 kb double-stranded DNA genome protected by a protein capsid decorated with Ad fiber protein spikes that target infection to receptors on specific cell types. Adenoviruses do not integrate into host DNA, can be produced to high titers using established protocols, and have proven safety in human gene therapy and cancer applications. Thus, Ad-based vectors have enormous promise for cancer diagnostics and therapies.

SUMMARY Disclosed herein are recombinant adenovirus genomes that include a heterologous open reading frame (ORF) and a self-cleaving peptide coding sequence. The heterologous ORF can encode, for example, a therapeutic protein. The recombinant adenovirus genomes and recombinant adenoviruses produced by the disclosed genomes can be used, for example, in therapeutic applications, such as for the treatment of cancer. Accordingly, in one aspect the present invention provides a recombinant adenovirus genome comprising a heterologous ORF and a self-cleaving peptide coding sequence, both operably linked to and in the same reading frame as an endogenous adenovirus ORF, wherein the self-cleaving peptide coding sequence is located between the heterologous ORF and the endogenous ORF, and wherein: the endogenous ORF is E1B-55k and the heterologous ORF is 3'of E1B-55k; the endogenous ORF is DNA polymerase and the heterologous ORF is 5' of DNA polymerase; the endogenous ORF is DNA binding protein (DBP) and the heterologous ORF is 3' of DBP; the endogenous ORF is adenovirus death protein (ADP) and the heterologous ORF is 5' of ADP; the endogenous ORF is E3-14.7k and the heterologous ORF is 3' of E3-14.7k; the endogenous ORF is E4-ORF2 and the heterologous ORF is 5' of E4-ORF2; or the endogenous ORF is fiber and the heterologous ORF is 3' of fiber, wherein the heterologous ORF encodes a therapeutic protein or a fluorescent protein. Further provided herein are recombinant adenoviruses that include a recombinant adenovirus genome disclosed herein. Also provided are compositions that include a recombinant adenovirus genome or recombinant adenovirus disclosed herein and a pharmaceutically acceptable carrier. Also provided is a method of delivering a therapeutic protein to a subject by administering to the subject a recombinant adenovirus genome or a recombinant adenovirus (or composition thereof) disclosed herein. In these methods, the heterologous ORF of the recombinant adenovirus genome or recombinant adenovirus encodes the therapeutic protein. Further provided are methods of inhibiting tumor cell viability, inhibiting tumor cell growth, inhibiting tumor progression, reducing tumor volume and treating a subject with cancer by administering a recombinant adenovirus genome or a recombinant adenovirus (or composition thereof) disclosed herein. In these methods, the heterologous ORF of the recombinant adenovirus genome or recombinant adenovirus encodes a therapeutic protein suitable for the treatment of cancer.

The foregoing and other features of the disclosure will become more apparent from the following detailed description, which proceeds with reference to the accompanying figures.

BRIEF DESCRIPTION OF THE DRAWINGS FIG. 1 is a schematic of an exemplary work-flow for testing adenoviral constructs. Whole virus genome plasmid is produced and transfected into suitable cells, such as 293-E4 cells, in a multi well plate. As transfected cells expand, they are subjected to freeze/thaw to release viral particles, followed by centrifugation to pellet cell debris. The supernatant (containing the viral particles) is transferred to multiple, larger culture plates. Viral particles are harvested from transfected cells, CsC purified and infectious virus titer is measured by ELISA. The cell type of interest is then infected with a known MOI of purified virus. At 48 or 72 hours post-infection, adenovirus late proteins, adenovirus genomes or plaques are measured by Western blot, q-PCR or plaque assay, respectively. FIG. 2 is a schematic showing exponential viral growth. Oncolytic killing of all cells within a tumor requires exponential viral growth. However, in most instances, only a small percentage of tumor cells are initially infected. Thus, a small difference in the number of progeny per round of replication leads to large differences in the total number of particles after just a few rounds of replication. Shown is a comparison between a virus that produces 3 virions per cycle and a virus that produces 5 virions per cycle. As shown in the graph, after 5-6 rounds of replication, viral titers of the two viruses are significantly different. FIG. 3 is a schematic showing an exemplary work-flow of a fluorescence-based viral kinetic (FBVK) assay. Whole virus genome plasmid is produced (such as by Adsembly or AdSLIC) and used to transfect a cell type of interest in a multi-well plate. Alternatively, cells are infected with recombinant adenovirus particles. The adenovirus genome comprises at least one open reading frame (ORF) encoding a fluorescent protein in a location within the viral genome that does not substantially alter viral replication kinetics. Fluorescence is monitored over time to calculate viral replication kinetics. Oncolytic virus candidates are those exhibiting the largest differential in virus kinetics between tumor cells and normal cells. FIGS. 4A-4B outline the kinetic assay setup when starting with adenovirus genome plasmids. This assay does not require accurate knowledge of initial transfection efficiency. Transfection conditions are selected to result in approximately 5-10% of cells initially transfected. Intheexample shown, a 48-well plate is used, which allows for the testing of 14 different virus constructs in triplicate, along with three mock-infected wells and three wells with FLUORESBRITE' beads to compensate for tool sensitivity drift. (FIG. 4A) The wells of the upper half of the 48-well plate contain cells transfected with the genome plasmids of 6 different viruses, mock-infected cells, and blanks ) (FLUORESBRITEm beads), each in triplicate. (FIG. 4B) The wells of the lower half of the 48-well plate contain cells transfected with the genome plasmids of 8 different viruses in triplicate. The multi well plate is placed on a plate reader (such as a TECAN plate reader) for continuous fluorescence monitoring. FIG. 5 outlines the kinetic assay setup when starting with recombinant virus. This assay does not require accurate knowledge of virus titer. Recombinant virus is serially diluted and used to infect cells plated in a multi-well plate. In the example shown, a 96-well plate is used and each virus is diluted 1:100, 1:300, 1:900, 1:2700, 1:8100, 1:24,300, 1:72,900 and 1:218,700, allowing for the testing of 11 viruses simultaneously. Four wells are mock-infected and FLUORESBRITE' beads are placed in four wells to compensate for tool sensitivity and drift. The multi-well plate is placed on a plate ) reader (such as a TECAN plate reader) for continuous fluorescence monitoring. FIGS. 6A-6C provide a schematic overview of the Adsembly and AdSLIC techniques for the combinatorial assembly of recombinant adenoviruses. (FIG. 6A) The adenovirus genome is separated into four modules - El, core, E3 and E4. (FIG. 6B) Adsembly involves genome reassembly using multi-site Gateway reactions. (FIG. 6C) AdSLIC utilizes sequence and ligation independent cloning (SLIC) to assemble adenovirus modules. FIG. 7 is a bar graph showing In-slope values for recombinant adenoviruses encoding a fluorescent protein in the El region. Shown are the values for the direct fusion construct YPet-E1A, and the YPet-P2A-E1A, E1A-P2A-mCherry and E1B-55k-P2A-YPet constructs, which each contain a P2A site. The YPet-P2A-ADP construct is shown for comparison. FIG. 8 is a schematic of kinetic data analysis and interpretation for the fluorescence-based viral kinetic assay. FIGS. 9A-9C are bar graphs showing n-slope values for recombinant adenoviruses derived from Ad5, Ad9 or Ad34 and containing a heterologous ORF 3'of the E3-14.7k ORF (or equivalent thereof in Ad9 and Ad34). Shown are the values for Ad5 (E3-14.7k-P2A-YPet; PCMN-887), Ad9 (E3-15k-P2A-YPet; PCMN-888) and Ad34 (E3-14.8k-P2A-YPet; PCMN-889) in 293 cells (FIG. 9A), A549 cells (FIG. 9B) and U20S cells (FIG. 9C). Also shown in each figure are values for chimeric viruses comprising an Ad5 core (including E3-14.7k-P2A-YPet) and fiber shaft/knob from either Ad9 (Ad5/Ad9) or Ad34 (Ad5/Ad34).

SEQUENCE LISTING The nucleic and amino acid sequences listed in the accompanying sequence listing are shown ) using standard letter abbreviations for nucleotide bases, and three letter code for amino acids, as defined in 37 C.F.R. 1.822. Only one strand of each nucleic acid sequence is shown, but the complementary strand is understood as included by any reference to the displayed strand. The Sequence Listing is submitted as an ASCII text file, created on February 21, 2017, 703 KB, which is incorporated by reference herein. In the accompanying sequence listing: SEQ ID NO: 1 is the nucleotide sequence of synthetic adenovirus genome CMBT-379 (YPet P2A-E1A). SEQ ID NO: 2 is the nucleotide sequence of synthetic adenovirus genome CMBT-432 (E1A P2A-YPet). SEQ ID NO: 3 is the nucleotide sequence of synthetic adenovirus genome CMBT-456 (ElB ) 55k-P2A-YPet). SEQ ID NO: 4 is the nucleotide sequence of synthetic adenovirus genome CMBT-499 (EiB 55k-P2A-mCherry).

SEQ ID NO: 5 is the nucleotide sequence of synthetic adenovirus genome CMBT-530 (YPet P2A-(DNA Poly)). SEQ ID NO: 6 is the nucleotide sequence of synthetic adenovirus genome CMBT-886 (DBP P2A-YPet). SEQ ID NO: 7 is the nucleotide sequence of synthetic adenovirus genome CMBT-403 (YPet P2A-ADP). SEQ ID NO: 8 is the nucleotide sequence of synthetic adenovirus genome CMBT-429 (ADP P2A-YPet). SEQ ID NO: 9 is the nucleotide sequence of synthetic adenovirus genome PCMN-887 (E3 14.7k-P2A-YPet). SEQ ID NO: 10 is the nucleotide sequence of synthetic adenovirus genome CMBT-457 (YPet P2A-E4-ORF2). SEQ ID NO: 11 is the nucleotide sequence of synthetic adenovirus genome CMBT-633 (mCherry-P2A-E4-ORF2). SEQ ID NO: 12 is the nucleotide sequence of synthetic adenovirus genome CMBT-407 (YPet P2A-Fiber).

SEQ ID NO: 13 is the nucleotide sequence of synthetic adenovirus genome CMBT-445 (Fiber P2A-YPet). SEQ ID NO: 14 is the amino acid sequence of P2A. SEQ ID NO: 15 is the amino acid sequence of F2A. SEQ ID NO: 16 is the amino acid sequence of E2A. SEQ ID NO: 17 is the amino acid sequence of T2A. SEQ ID NO: 18 is the amino acid sequence of a modified P2A comprising GSG at the N terminus.

SEQ ID NO: 19 is the amino acid sequence of a modified F2A comprising GSG at the N terminus. SEQ ID NO: 20 is the amino acid sequence of a modified E2A comprising GSG at the N terminus. SEQ ID NO: 21 is the amino acid sequence of a modified T2A comprising GSG at the N ) terminus.

SEQ ID NO: 22 is the nucleotide sequence of synthetic adenovirus genome PCMN-888 (Ad9 E3-15k-P2A-YPet).

SEQ ID NO: 23 is the nucleotide sequence of synthetic adenovirus genome PCMN-889 (Ad34 E3-14.8k-P2A-YPet).

DETAILED DESCRIPTION I. Abbreviations Ad adenovirus ADP adenovirus death protein BFP blue fluorescent protein E2A equine rhinitis A virus 2A ELISA enzyme-linked immunosorbent assay ERAV equine rhinitis A virus F2A foot and mouth disease virus 2A FACS fluorescence activated cells sorting FMDV food and mouth disease virus GFP green fluorescent protein MOI multiplicity of infection

OD optical density ORF open reading frame P2A porcine teschovirus-1 2A pIX protein IX PTV1 porcine teschovirus-1 RFP red fluorescent protein SLIC sequence and ligation independent cloning T2A Thosea asigna virus 2A

TaV Thosea asigna virus YFP yellow fluorescent protein

II. Terms and Methods Unless otherwise noted, technical terms are used according to conventional usage. Definitions ) of common terms in molecular biology may be found in Benjamin Lewin, Genes V, published by Oxford University Press, 1994 (ISBN 0-19-854287-9); Kendrew et al. (eds.), The Encyclopediaof Molecular Biology, published by Blackwell Science Ltd., 1994 (ISBN 0-632-02182-9); and Robert A.

Meyers (ed.), MolecularBiology and Biotechnology: a ComprehensiveDesk Reference, published by VCH Publishers, Inc., 1995 (ISBN 1-56081-569-8). In order to facilitate review of the various embodiments of the disclosure, the following explanations of specific terms are provided: 2A peptide: A type of self-cleaving peptide encoded by some RNA viruses, such as picornaviruses. 2A peptides function by making the ribosome skip the synthesis of a peptide bond at the C-terminus of a 2A element, leading to separation between the end of the 2A sequence and the downstream peptide (Kim etal., PLoS One 6(4):e18556, 2011). The "cleavage" occurs between the glycine and proline residues found on the C-terminus of the 2A peptide. Exemplary 2A peptides include, but are not limited to, the 2A peptides encoded by Thosea asigna virus (TaV), equine rhinitis A virus (ERAV), porcine teschovirus-1 (PTV1) and foot and mouth disease virus (FMDV), which are set forth herein as SEQ ID NOs: 14-17). In some embodiments, the 2A peptide comprises Gly-Ser-Gly at the N-terminus to improve cleavage efficiency (SEQ ID NOs: 18-21). Adenovirus: A non-enveloped virus with a linear, double-stranded DNA genome and an icosahedral capsid. There are currently 68 known serotypes of human adenovirus, which are divided into seven species (species A, B, C, D, E, F and G). Different serotypes of adenovirus are associated with different types of disease, with some serotypes causing respiratory disease (primarily species B and C), conjunctivitis (species B and D) and/or gastroenteritis (species F and G). Adenovirus death protein (ADP): A protein synthesized in the late stages of adenovirus ) infection that mediates lysis of cells and release of adenovirus to infect other cells. ADP is an integral membrane glycoprotein of 101 amino acids that localizes to the nuclear membrane, endoplasmic reticulum and Golgi. ADP was previously named E3-11.6K). Administration: To provide or give a subject an agent, such as a therapeutic agent (e.g. a recombinant virus), by any effective route. Exemplary routes of administration include, but are not limited to, injection (such as subcutaneous, intramuscular, intradermal, intraperitoneal, intratumoral, and intravenous), oral, intraductal, sublingual, rectal, transdermal, intranasal, vaginal and inhalation routes. Chimeric: Composed of at least two parts having different origins. In the context of the present disclosure, a "chimeric adenovirus" is an adenovirus having genetic material and/or proteins ) derived from at least two different serotypes (such as from Ad5 and a second serotype of adenovirus). In this context, a "capsid-swapped" adenovirus refers to a chimeric adenovirus in which the capsid proteins are derived from one serotype of adenovirus and the remaining proteins are derived from another adenovirus serotype. Similarly, a "chimeric fiber" is a fiber protein having amino acid sequence derived from at least two different serotypes of adenovirus. For example, a chimeric fiber can be composed of a fiber shaft from Ad5 and a fiber knob from a second serotype of adenovirus. In another example, a chimeric fiber is composed of an Ad5 tail and a fiber shaft and knob from a second serotype of adenovirus (such as Ad9 or Ad34). Contacting: Placement in direct physical association; includes both in solid and liquid form. Degenerate variant: In the context of the present disclosure, a "degenerate variant" refers to a polynucleotide encoding a peptide that includes a sequence that is degenerate as a result of the genetic code. There are 20 natural amino acids, most of which are specified by more than one codon. Therefore, all degenerate nucleotide sequences encoding a peptide are included as long as the amino acid sequence of the peptide encoded by the nucleotide sequence is unchanged. Deleted: An adenovirus genome encoding a "deleted" protein (such as the E4orfl or E4orf6/7 protein) refers to an adenovirus having a complete deletion of the protein coding sequence, or a partial deletion that results in the absence of protein expression. Deregulation of E2F: Refers to an increase in activity of the E2 transcription factor and downstream target genes, which occurs in nearly all types of human cancer. Deregulation of the E2F pathway activity and transcription can result from a variety of different mutations in any upstream component of the pathway, such as loss of function mutations and deletions in Rb, p107 and p130 tumor suppressors. Rb was the first tumor suppressor to be identified and is absent or mutated in at least one third of human tumors. In addition, p16 mutations and/or epigenetic silencing can activate E2F in tumor cells. Cyclin D and CDK4 mutations, gene amplifications or over-expression can also result in deregulated E2F activity in human tumors. In addition E2F is activated by growth factor receptor pathway mutations including EGFR, RTKs, RAS, RAF, PI-3K, PTEN, RAF, MYC. Mutations in the p1 6 INK4a -Cyclin D:cdk4/6-RB-E2F pathway generally occur in a mutually exclusive fashion, so that one 'hit' (for example, p16) is unaccompanied by others (for example, Rb mutation or cyclin D:cdk over-expression). However, most current chemotherapies are proliferative poisons that inhibit E2F transcriptional targets, but are also toxic to normal cells and have often devastating iatrogenic complications. As disclosed herein, an alternative therapeutic approach is to use a virus that undergoes selective lytic replication in cancer cell lesions that have deregulated the p16-cyclin D:cdk4 RB-E2F pathway.

DNA-binding protein (DBP): This adenovirus protein binds to single-stranded DNA and RNA, as well as double-stranded DNA. DBP, a 72-kilodalton protein, is essential for replication of adenoviral DNA. E1A: The adenovirus early region 1A (E1A) gene and polypeptides expressed from the gene. The ElA protein plays a role in viral genome replication by driving cells into the cell cycle. As used herein, the term "E1A protein" refers to the proteins expressed from the E1A gene and the term includes ElA proteins produced by any adenovirus serotype.

E3-RIDa/RIDS and E3-14.7k: Early-expressed proteins produced from the E3 gene. The

E3-RIDu, E3-RIDP, and E3-14.7k proteins make up the receptor internalization and degradation ) complex (RID), which localizes to the nuclear membrane and causes the endocytosis and degradation of a variety of receptors including CD95 (FasL receptor), and TNFR1 and 2 (TNF/TRAIL receptors) to protect infected cells from host antiviral responses. The E3-RIDa, E3-RID3, and E3-14.7k coding sequences are next to each other, in this order. E4orfl: An adenovirus protein produced from the E4 gene. The term "E4orfl protein" includes E4orfl proteins produced by the E4 gene from any adenovirus serotype. E4orf6/7: A protein encoded by the adenovirus E4 gene. The term "E4orf6/7 protein" includes E4orf6/7 proteins produced by the E4 gene from any adenovirus serotype. Fiber: The adenovirus fiber protein is a trimeric protein that mediates binding to cell surface receptors. The fiber protein is comprised of a long N-terminal shaft and globular C-terminal knob. Fluorescent protein: A protein that emits light of a certain wavelength when exposed to a particular wavelength of light. Fluorescent proteins include, but are not limited to, green fluorescent proteins (such as GFP, EGFP, AcGFP1, Emerald, Superfolder GFP, Azami Green, mWasabi, TagGFP, TurboGFP and ZsGreen), blue fluorescent proteins (such as EBFP, EBFP2, Sapphire, T-Sapphire, Azurite and mTagBFP), cyan fluorescent proteins (such as ECFP, mECFP, Cerulean, CyPet, AmCyanl, Midori-Ishi Cyan, mTurquoise and mTFP1), yellow fluorescent proteins (EYFP, Topaz, Venus, mCitrine, YPet, TagYFP, PhiYFP, ZsYellowl and mBanana), orange fluorescent proteins (Kusabira Orange, Kusabira Orange2, mOrange, mOrange2 and mTangerine), red fluorescent proteins (mRuby, mApple, mStrawberry, AsRed2, mRFP1, JRed, mCherry, HcRedl, mRaspberry, dKeima Tandem, HcRed-Tandem, mPlum, AQ143, tdTomato and E2-Crimson), orange/red fluorescence ) proteins (dTomato, dTomato-Tandem, TagRFP, TagRFP-T, DsRed, DsRed2, DsRed-Express (TI) and DsRed-Monomer) and modified versions thereof.

Fusion protein: A protein containing amino acid sequence from at least two different (heterologous) proteins or peptides. Fusion proteins can be generated, for example, by expression of a nucleic acid sequence engineered from nucleic acid sequences encoding at least a portion of two different (heterologous) proteins. To create a fusion protein, the nucleic acid sequences must be in the same reading frame and contain no internal stop codons. Fusion proteins, particularly short fusion proteins, can also be generated by chemical synthesis. Heterologous: A heterologous protein or polypeptide refers to a protein or polypeptide derived from a different source or species. Hexon: A major adenovirus capsid protein. Immunomodulator: An agent that alters (e.g. activates, enhances or suppresses) the immune system. Immunomodulators include, but are not limited to, cytokines (such as interleukin 2 (IL-2), IL 7, IL-12, GM-CSF, FLT3 ligand, or interferons), chemokines (such as CCL3, CCL26, CXCL7, CXCL9, and CXCL1), T cell activating ligands (such as anti-CD3 Abs or alloantigens), co stimulatory molecules (such as B7.1/B7.2, OX40L, 4-1-BBL or CD40L), checkpoint blockade inhibitors (such as anti-PD-i or anti-CTLA4 Abs), and small molecule immunomodulators. Isolated: An "isolated" biological component (such as a nucleic acid molecule, protein, virus

or cell) has been substantially separated or purified away from other biological components in the cell or tissue of the organism, or the organism itself, in which the component naturally occurs, such as other chromosomal and extra-chromosomal DNA and RNA, proteins and cells. Nucleic acid ) molecules and proteins that have been "isolated" include those purified by standard purification methods. The term also embraces nucleic acid molecules and proteins prepared by recombinant expression in a host cell as well as chemically synthesized nucleic acid molecules and proteins. Modification: A change in the sequence of a nucleic acid or protein sequence. For example, amino acid sequence modifications include, for example, substitutions, insertions and deletions, or

combinations thereof. Insertions include amino and/or carboxyl terminal fusions as well as intrasequence insertions of single or multiple amino acid residues. Deletions are characterized by the removal of one or more amino acid residues from the protein sequence. In some embodiments herein, the modification (such as a substitution, insertion or deletion) results in a change in function, such as a reduction or enhancement of a particular activity of a protein. As used herein, "A" or "delta" refer to a ) deletion. Substitutional modifications are those in which at least one residue has been removed and a different residue inserted in its place. Amino acid substitutions are typically of single residues, but can occur at a number of different locations at once. Substitutions, deletions, insertions or any combination thereof may be combined to arrive at a final mutant sequence. These modifications can be prepared by modification of nucleotides in the DNA encoding the protein, thereby producing DNA encoding the modification. Techniques for making insertion, deletion and substitution mutations at predetermined sites in DNA having a known sequence are well known in the art. A "modified" protein, nucleic acid or virus is one that has one or more modifications as outlined above. Neoplasia, malignancy, cancer and tumor: A neoplasm is an abnormal growth of tissue or cells that results from excessive cell division. Neoplastic growth can produce a tumor. The amount of a tumor in an individual is the "tumor burden" which can be measured as the number, volume, or weight of the tumor. A tumor that does not metastasize is referred to as "benign." A tumor that invades the surrounding tissue and/or can metastasize is referred to as "malignant." Malignant tumors are also referred to as "cancer." Hematologic cancers are cancers of the blood or bone marrow. Examples of hematological (or hematogenous) cancers include leukemias, including acute leukemias (such as acute lymphocytic leukemia, acute myelocytic leukemia, acute myelogenous leukemia and myeloblastic, promyelocytic, myelomonocytic, monocytic and erythroleukemia), chronic leukemias (such as chronic myelocytic (granulocytic) leukemia, chronic myelogenous leukemia, and chronic lymphocytic leukemia), polycythemia vera, lymphoma, Hodgkin's disease, non-Hodgkin's lymphoma (indolent and high grade forms), multiple myeloma, Waldenstrom's macroglobulinemia, heavy chain disease, myelodysplastic syndrome, hairy cell leukemia and myelodysplasia. In some cases, lymphomas are considered solid ) tumors. Solid tumors are abnormal masses of tissue that usually do not contain cysts or liquid areas. Solid tumors can be benign or malignant. Different types of solid tumors are named for the type of cells that form them (such as sarcomas, carcinomas, and lymphomas). Examples of solid tumors, such as sarcomas and carcinomas, include fibrosarcoma, myxosarcoma, liposarcoma, chondrosarcoma, osteosarcoma, and other sarcomas, synovioma, mesothelioma, Ewing's tumor, leiomyosarcoma, rhabdomyosarcoma, colon carcinoma, lymphoid malignancy, pancreatic cancer, breast cancer, lung cancers, ovarian cancer, prostate cancer, hepatocellular carcinoma, squamous cell carcinoma, basal cell carcinoma, adenocarcinoma, sweat gland carcinoma, medullary thyroid carcinoma, papillary thyroid carcinoma, pheochromocytomas sebaceous gland carcinoma, papillary carcinoma, human papilloma ) virus (HPV)-infected neoplasias, papillary adenocarcinomas, medullary carcinoma, bronchogenic carcinoma, renal cell carcinoma, hepatoma, bile duct carcinoma, choriocarcinoma, Wilms'tumor, cervical cancer, testicular tumor, seminoma, bladder carcinoma, melanoma, and CNS tumors (such as a glioma (such as brainstem glioma and mixed gliomas), glioblastoma (also known as glioblastoma multiforme) astrocytoma, CNS lymphoma, germinoma, medulloblastoma, Schwannoma craniopharyogioma, ependymoma, pinealoma, hemangioblastoma, acoustic neuroma, oligodendroglioma, menangioma, neuroblastoma, retinoblastoma and brain metastasis). Oncolytic virus: A virus that selectively kills cells of a proliferative disorder, e.g., cancer/tumor cells. Killing of the cancer cells can be detected by any method established in the art, such as determining viable cell count, or detecting cytopathic effect, apoptosis, or synthesis of viral proteins in the cancer cells (e.g., by metabolic labeling, immunoblot, or RT-PCR of viral genes necessary for replication), or reduction in size of a tumor. Operably linked: A first nucleic acid sequence is operably linked with a second nucleic acid sequence when the first nucleic acid sequence is placed in a functional relationship with the second nucleic acid sequence. For instance, a promoter is operably linked to a coding sequence if the promoter affects the transcription or expression of the coding sequence. Generally, operably linked DNA sequences are contiguous and, where necessary to join two protein-coding regions, in the same reading frame. Pharmaceutically acceptable carrier: The pharmaceutically acceptable carriers (vehicles) useful in this disclosure are conventional. Remington's PharmaceuticalSciences, by E. W. Martin, Mack Publishing Co., Easton, PA, 15th Edition (1975), describes compositions and formulations suitable for pharmaceutical delivery of one or more therapeutic compounds, molecules or agents (e.g. a ) recombinant virus disclosed herein). In general, the nature of the carrier will depend on the particular mode of administration being employed. For instance, parenteral formulations usually comprise injectable fluids that include pharmaceutically and physiologically acceptable fluids such as water, physiological saline, balanced salt solutions, aqueous dextrose, glycerol or the like as a vehicle. For solid compositions (for example, powder, pill, tablet, or capsule forms), conventional non-toxic solid carriers can include, for example, pharmaceutical grades of mannitol, lactose, starch, or magnesium stearate. In addition to biologically neutral carriers, pharmaceutical compositions to be administered can contain minor amounts of non toxic auxiliary substances, such as wetting or emulsifying agents, preservatives, and pH buffering agents and the like, for example sodium acetate or sorbitan monolaurate. Polypeptide, peptide or protein: A polymer in which the monomers are amino acid residues which are joined together through amide bonds. When the amino acids are alpha-amino acids, either the L-optical isomer or the D-optical isomer can be used. The terms "polypeptide," "peptide" and

"protein" are used interchangeably herein. These terms apply to amino acid polymers in which one or more amino acid residue is an artificial chemical mimetic of a corresponding naturally occurring amino acid, as well as to naturally occurring amino acid polymers and non-naturally occurring amino acid polymers. The term "residue" or "amino acid residue" includes reference to an amino acid that is incorporated into a protein, polypeptide, or peptide. A conservative substitution in a polypeptide is a substitution of one amino acid residue in a protein sequence for a different amino acid residue having similar biochemical properties. Typically, conservative substitutions have little to no impact on the activity of a resulting polypeptide. For example, a protein or peptide including one or more conservative substitutions (for example no more than 1, 2, 3, 4 or 5 substitutions) retains the structure and function of the wild-type protein or peptide. A polypeptide can be produced to contain one or more conservative substitutions by manipulating the nucleotide sequence that encodes that polypeptide using, for example, standard procedures such as site directed mutagenesis or PCR. In one example, such variants can be readily selected by testing antibody cross-reactivity or its ability to induce an immune response. Examples of conservative substitutions are shown below.

Original Residue Conservative Substitutions

Ala Ser Arg Lys Asn Gln, His Asp Glu Cys Ser Gln Asn Glu Asp His Asn; Gln Ile Leu, Val Leu Ile; Val Lys Arg; Gln; Glu Met Leu; Ile Phe Met; Leu; Tyr Ser Thr Thr Ser

Trp Tyr Tyr Trp; Phe Val Ile; Leu Conservative substitutions generally maintain (a) the structure of the polypeptide backbone in the area of the substitution, for example, as a sheet or helical conformation, (b) the charge or hydrophobicity of the molecule at the target site, or (c) the bulk of the side chain. The substitutions which in general are expected to produce the greatest changes in protein properties will be non-conservative, for instance changes in which (a) a hydrophilic residue, for example, seryl or threonyl, is substituted for (or by) a hydrophobic residue, for example, leucyl, isoleucyl, phenylalanyl, valyl or alanyl; (b) a cysteine or proline is substituted for (or by) any other residue; (c) a residue having an electropositive side chain, for example, lysyl, arginyl, or histadyl, is substituted for (or by) an electronegative residue, for example, glutamyl or aspartyl; or (d) a residue having a bulky side chain, for example, phenylalanine, is substituted for (or by) one not having a side chain, for example, glycine. Preventing, treating or ameliorating a disease: "Preventing" a disease refers to inhibiting the full development of a disease. "Treating" refers to a therapeutic intervention that ameliorates a

sign or symptom of a disease or pathological condition after it has begun to develop. "Ameliorating" refers to the reduction in the number or severity of signs or symptoms of a disease. Promoter: A region of DNA that directs/initiates transcription of a nucleic acid (e.g. a gene). A promoter includes necessary nucleic acid sequences near the start site of transcription. Typically, promoters are located near the genes they transcribe. A promoter also optionally includes distal enhancer or repressor elements which can be located as much as several thousand base pairs from the start site of transcription. A "constitutive promoter" is a promoter that is continuously active and is not subject to regulation by external signals or molecules. In contrast, the activity of an "inducible

promoter" is regulated by an external signal or molecule (for example, a transcription factor or tetracycline). Protein IX (pIX): A minor component of the adenovirus capsid that associates with the hexon protein. Purified: The term "purified" does not require absolute purity; rather, it is intended as a ) relative term. Thus, for example, a purified peptide, protein, virus, or other active compound is one that is isolated in whole or in part from naturally associated proteins and other contaminants. In certain embodiments, the term "substantially purified" refers to a peptide, protein, virus or other active compound that has been isolated from a cell, cell culture medium, or other crude preparation and subjected to fractionation to remove various components of the initial preparation, such as proteins, cellular debris, and other components. Recombinant: A recombinant nucleic acid molecule, protein or virus is one that has a sequence that is not naturally occurring or has a sequence that is made by an artificial combination of two otherwise separated segments of sequence. This artificial combination can be accomplished by chemical synthesis or by the artificial manipulation of isolated segments of nucleic acid molecules, such as by genetic engineering techniques. The term "recombinant" also includes nucleic acids, proteins and viruses that have been altered solely by addition, substitution, or deletion of a portion of the natural nucleic acid molecule, protein or virus. Replication defects: An adenovirus that exhibits "replication defects" in a non-tumor cell (compared to a tumor cell) refers to an adenovirus that exhibits reduced viral replication in normal cells compared to tumor cells. Replication defects are evidenced by, for example, a lack of viral late protein expression, a reduction in viral DNA synthesis, a reduced ability to induce E2F target genes (e.g. cyclin A and B), a reduced ability to elicit S phase entry and/or a reduced ability to induce cell killing in normal cells compared to tumor cells. Replication deficient virus: A virus that preferentially inhibits cell proliferation, causes cell lysis, or induces apoptosis (collectively considered killing) in a predetermined cell population with a given phenotype (e.g., tumor cells with a deregulated E2F pathway). Such viruses are unable to or are ) limited in the ability to reduce or inhibit cell proliferation, cause cell lysis, induce apoptosis, or otherwise replicate in cells that do not have the predetermined cell phenotype (such as normal, non tumor cells). Self-cleaving peptides: Peptides that induce the ribosome to skip the synthesis of a peptide bond at the C-terminus, leading to separation of the peptide sequence and a downstream polypeptide. Virally encoded 2A peptides are a type of self-cleaving peptide. Virally encoded 2A peptides include, for example, 2A peptides from porcine teschovirus-1 (PTV1), foot and mouth disease virus (FMDV), equine rhinitis A virus (ERAV) and Thosea asigna virus (TaV). Sequence identity: The identity or similarity between two or more nucleic acid sequences, or two or more amino acid sequences, is expressed in terms of the identity or similarity between the ) sequences. Sequence identity can be measured in terms of percentage identity; the higher the percentage, the more identical the sequences are. Sequence similarity can be measured in terms of percentage similarity (which takes into account conservative amino acid substitutions); the higher the percentage, the more similar the sequences are. Homologs or orthologs of nucleic acid or amino acid sequences possess a relatively high degree of sequence identity/similarity when aligned using standard methods. This homology is more significant when the orthologous proteins or cDNAs are derived from species which are more closely related (such as human and mouse sequences), compared to species more distantly related (such as human and C. elegans sequences). Methods of alignment of sequences for comparison are well known in the art. Various programs and alignment algorithms are described in: Smith & Waterman, Adv. Apple. Math. 2:482, 1981; Needleman & Wunsch, J. Mol. Biol. 48:443, 1970; Pearson & Lipman, Proc. Nat. Acad. Sci. USA 85:2444, 1988; Higgins & Sharp, Gene, 73:237-44, 1988; Higgins & Sharp, CABIOS 5:151-3, 1989; Corpet et al., Nuc. Acids Res. 16:10881-90, 1988; Huang et al. Computer Apps. in the Biosciences 8, 155-65, 1992; and Pearson et al., Meth. Mol. Bio. 24:307-31, 1994. Altschul et al., J. Mol. Biol. 215:403-10, 1990, presents a detailed consideration of sequence alignment methods and homology calculations. The NCBI Basic Local Alignment Search Tool (BLAST) (Altschul et al., J. Mol. Biol. 215:403 10, 1990) is available from several sources, including the National Center for Biological Information (NCBI) and on the internet, for use in connection with the sequence analysis programs blastp, blastn, blastx, tblastn and tblastx. Additional information can be found at the NCBI web site. Serotype: A group of closely related microorganisms (such as viruses) distinguished by a characteristic set of antigens. Subject: Living multi-cellular vertebrate organisms, a category that includes human and non human mammals. Synthetic: Produced by artificial means in a laboratory, for example a synthetic nucleic acid or protein can be chemically synthesized in a laboratory. Therapeutic agent: Any agent capable of inducing a desired therapeutic or prophylactic effect when properly administered to a subject. Therapeutic agents include, but are not limited to, chemical compounds, small molecules, recombinant viruses, antisense compounds, antibodies (or antigen binding fragments thereof), peptides or nucleic acid molecules. For example, therapeutic agents for treating cancer include agents that prevent or inhibit tumor growth, tumor development, or tumor metastasis. "Therapeutic proteins" are therapeutic agents that are proteins or peptides, including ) antibodies or antigen-binding fragments thereof. In some embodiments herein, the therapeutic protein is an immunomodulator. In other embodiments, the therapeutic protein comprises a toxin, Fas or FasL, a soluble death factor, a mediator of bystander destruction, a tumor antigen, a neo antigen or an alloantigen. Therapeutically effective amount: A quantity of a specified pharmaceutical or therapeutic agent (e.g. a recombinant virus) sufficient to achieve a desired effect in a subject, or in a cell, being treated with the agent. The effective amount of the agent can be dependent on several factors, including, but not limited to the subject or cells being treated, and the manner of administration of the therapeutic composition. Uexon: An open reading frame located on the/ strand (leftward transcription) between the early E3 region and the fiber gene (Tollefson et al, J Virol 81(23):12918-12926).

Unless otherwise explained, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this disclosure belongs. The singular terms "a," "an," and "the" include plural referents unless context clearly indicates otherwise. "Comprising A or B" means including A, or B, or A and B. It is further to be understood that all base sizes or amino acid sizes, and all molecular weight or molecular mass values, given for nucleic acids or polypeptides are approximate, and are provided for description. Although methods and materials similar or equivalent to those described herein can be used in the practice or testing of the present disclosure, suitable methods and materials are described below. All publications, patent applications, patents, and other references mentioned herein are incorporated by reference in their ) entirety. In case of conflict, the present specification, including explanations of terms, will control. In addition, the materials, methods, and examples are illustrative only and not intended to be limiting.

III. Overview of Embodiments Disclosed herein are recombinant adenovirus genomes that include a heterologous open reading frame (ORF) and a self-cleaving peptide coding sequence. The heterologous ORF can encode, for example, a therapeutic protein (such as an immunomodulator). The recombinant adenovirus genomes and recombinant adenoviruses produced by the disclosed genomes can be used, for example, in a variety of different therapeutic applications, such as the treatment of cancer. Provided herein are recombinant adenovirus genomes that include a heterologous ORF and a ) self-cleaving peptide coding sequence, both operably linked to and in the same reading frame as an endogenous adenovirus ORF. The self-cleaving peptide coding sequence is located between the heterologous ORF and the endogenous ORF. In some embodiments, the endogenous ORF is E1B-55k and the heterologous ORF is 3'of E1B-55k; the endogenous ORF is DNA polymerase and the heterologous ORF is 5' of DNA polymerase; the endogenous ORF is DNA-binding protein (DBP) and the heterologous ORF is 3' of DBP; the endogenous ORF is adenovirus death protein (ADP) and the heterologous ORF is 5'of ADP; the endogenous ORF is E3-14.7k and the heterologous ORF is 3'of E3-14.7k;the endogenous ORF is E4-ORF2 and the heterologous ORF is 5' of E4-ORF2; or the endogenous ORF is fiber and the heterologous ORF is 3' of fiber. In some embodiments, the heterologous ORF encodes a therapeutic protein. In some embodiments, the self-cleaving peptide is a 2A peptide or variant thereof. In some examples, the 2A peptide includes a porcine teschovirus-1 (PTV1) 2A (P2A) peptide, a foot and mouth disease virus (FMDV) 2A (F2A) peptide, an equine rhinitis A virus (ERAV) 2A (E2A) peptide or a Thosea asigna virus (TaV) 2A (T2A) peptide, or a variant thereof In particular examples, the P2A peptide sequence is at least 80%, at least 85%, at least 90%, at least 95%, at least 96%, at least 97%, at least 98% or at least 99% identical to the amino acid sequence of SEQ ID NO: 14 or SEQ ID NO: 18. In some examples, the 2A peptide variant comprises additional amino acid sequence (such as GSG) at the N-terminus. In particular examples, the F2A peptide sequence is at least 80%, at least 85%, at least 90%, at least 95%, at least 96%, at least 97%, at least 98% or at least 99% identical to the amino acid sequence of SEQ ID NO: 15 or SEQ ID NO: 19. In particular examples, the E2A peptide sequence is at least 80%, at least 85%, at least 90%, at least 95%, at least 96%, at least 97%, at least 98% or at least 99% ) identical to the amino acid sequence of SEQ ID NO: 16 or SEQ ID NO: 20. In particular examples, the T2A peptide sequence is at least 80%, at least 85%, at least 90%, at least 95%, at least 96%, at least 97%, at least 98% or at least 99% identical to the amino acid sequence of SEQ ID NO: 17 or SEQ ID NO: 21. In specific non-limiting examples, the self-cleaving peptide comprises or consists of the amino acid sequence of any one of SEQ ID NOs: 14-21. In some embodiments, the adenovirus is an adenovirus type 5 (Ad5). In other embodiments, the adenovirus is an Ad2, Ad3, Ad9, Ad11, Adl2 or Ad34. In yet other embodiments, the adenovirus is a chimeric adenovirus, such as, but not limited to, an Ad5/Ad9 or Ad5/Ad34 chimeric adenovirus. Further provided herein are recombinant adenoviruses that include a recombinant adenovirus genome disclosed herein. The recombinant adenoviruses (and recombinant adenovirus genomes) provided herein optionally include additional modifications, such as to target the virus to specific cell types, to inhibit targeting to and replication in the liver, to allow for selective replication in tumor cells, and to evade pre-existing neutralizing antibodies to common adenovirus serotypes. The additional modifications can vary depending on the desired use of the recombinant adenovirus. Adenovirus modifications are described, for example, in PCT Application No. PCT/US2015/051745 (filed September 23, 2015), WO 2012/024350, WO 2013/138505 and WO 2014/153204, which are herein incorporated by reference in their entirety. Compositions that include a recombinant adenovirus genome, or a recombinant adenovirus, and a pharmaceutically acceptable carrier are also provided by the present disclosure. Also provided herein are methods of delivering a therapeutic protein to a subject. Insome embodiments, the method includes administering to the subject a recombinant adenovirus genome, a recombinant adenovirus, or a composition disclosed herein. In these methods, the heterologous ORF of the recombinant adenovirus or recombinant adenovirus genome encodes the therapeutic protein. Further provided are methods of reducing or inhibiting tumor cell viability and/or tumor cell growth (for example a reduction of at least 10%, at at l20%,atleast 30%, at least 40%, at least 50%, at least 75%, at least 90%, at least 95%, or at least 98%, as compared to an absence of the disclosed therapy). In some embodiments, the method includes contacting the tumor cell with a recombinant adenovirus genome, a recombinant adenovirus, or a composition disclosed herein. In these methods, the heterologous ORF encodes a therapeutic protein. In some examples, the method is an in vitro method. In other examples, the method is an in vivo method and contacting the tumor cell includes administering the recombinant adenovirus genome, recombinant adenovirus, or composition to a ) subject with a tumor. Methods of reducing or inhibiting tumor progression, such as by reducing the number and/or size of a metastasis, or reducing tumor volume in a subject are further provided herein (for example a reduction of at least 10%, at least 20%, at least 30%, at least 40%, at least 50%, at least 75%, at least 90%, at least 9 5 %, or at least 9 8 %, as compared to an absence of the disclosed therapy). In some embodiments, the method includes administering to the subject a therapeutically effective amount of a recombinant adenovirus genome, a recombinant adenovirus, or a composition disclosed herein. In these methods, the heterologous ORF encodes a therapeutic protein. Further provided are methods of treating cancer in a subject. In some embodiments, the method includes administering to the subject a therapeutically effective amount of a recombinant ) adenovirus genome, a recombinant adenovirus, or a composition disclosed herein. In these methods, the heterologous ORF encodes a therapeutic protein.

In some embodiments herein, the method further includes administering an additional therapeutic agent to the subject. For example, the additional therapeutic agent may include an anti cancer agent, such as a chemotherapeutic agent, a biologic (such as an antibody or fragment thereof, such as a monoclonal antibody), or a nucleic acid molecule, such as an inhibitory nucleic acid molecule) or other therapeutic treatment, such as surgical resection of a tumor or irradiation of a tumor. Also provided herein are kits that include a recombinant adenovirus genome, a recombinant adenovirus, or a composition disclosed herein; and one or more additional therapeutic agents and/or one or more diagnostic agents. In some embodiments, the one or more additional therapeutic agents include a chemotherapeutic, biologic, or combinations thereof In some examples, the one or more diagnostic agents include one or more antibodies or nucleic acid molecules specific for a tumor marker, or an imaging probe that can be used to track the virus or tumor cells in vitro or in vivo.

IV. Optimal Placement of Exogenous ORFs The 36kb adenovirus genome is compact, using both the top and bottom strands for coding of various genes. At many locations within the adenovirus genome, both the top and bottom strand are used simultaneously for coding separate genes. The genome size has evolved to be optimal for insertion into its capsid. As a result, the insertion of exogenous genes is limited by the size capacity of the capsid as excessive addition of exogenous nucleic acid leads to incomplete genome loading into the capsid and reduced viral kinetics. A solution to the challenge presented by the limited available space in the adenovirus genome is to locate exogenous open reading frames (ORFs) as fusion products within native adenovirus ORFs. This strategy makes use of adenovirus promoters, 5'UTRs, and polyA tails already encoded in the genome. However, expression of a fusion between a native adenovirus protein and an exogenous protein can be deleterious to one or both protein functions and lead to a significant decrease in adenovirus replication kinetics. The present disclosure provides a solution to this problem by using a self-cleaving peptide sequence placed between the native (endogenous) ORF and the exogenous (heterologous) ORF. When placed between the two ORFs on a single mRNA, the presence of the self-cleaving peptide sequence leads to ribosome skipping and release of the first protein separate from the second protein. In some ) embodiments disclosed herein, the self-cleaving peptide is a 2A peptide (P2A). Also disclosed herein is the identification of optimal placement sites for heterologous ORFs within the adenovirus genome. The combination of the self-cleaving peptide sequence and the judicious placement of the heterologous ORF leads to high expression and minimal to no impact on viral kinetics. As described in Example 1 below, several sites within the adenovirus genome were identified that upon insertion of a heterologous ORF, did not inhibit adenovirus replication kinetics. In particular, it was determined that a heterologous ORF could be inserted C-terminal to the ElB-55k ORF, N-terminal to the DNA polymerase ORF, C-terminal to the DBP ORF, N-terminal to the ADP ORF, C-terminal to the E3-14.7k ORF or N-terminal to E4-ORF2. In each instance, a self-cleaving peptide sequence (P2A site) was inserted between the adenovirus ORF and the heterologous ORF. It is further disclosed herein that insertion of a heterologous ORF C-terminal to fiber produced a replication defective adenovirus; however, the recombinant virus was capable of producing extraordinarily high levels of heterologous protein in infected cells, which could prove useful in a number of therapeutic applications. Therefore, the present disclosure contemplates the use of the following recombinant adenoviruses for therapeutic applications (where "SC" refers to a sequence encoding a self-cleaving peptide, such as P2A): ElB-55k-SC-heterologous ORF heterologous ORF-SC-(DNA polymerase) DBP-SC-heterologous ORF heterologous ORF-SC-ADP E3-14.7k-SC-heterologous ORF heterologous ORF-SC-E4-ORF2 fiber-SC-heterologous ORF

In some embodiments herein, the self-cleaving peptide is a virally encoded 2A peptide, or a modified version thereof as described further below.

V. Self-Cleaving Peptide Sequences Self-cleaving peptides are peptides that induce the ribosome to skip the synthesis of a peptide bond at the C-terminus, leading to separation of the peptide sequence and a downstream polypeptide. ) The use of self-cleaving peptides allows for expression of multiple proteins flanking the self-cleaving peptide from a single ORF. Virally encoded 2A peptides are one type of self-cleaving peptide.

As with other self-cleaving peptides, 2A peptides function by making the ribosome skip the synthesis of a peptide bond at the C-terminus of a 2A element, leading to separation between the end of the 2A sequence and the downstream peptide (Kim et al., PLoS One 6(4):e18556, 2011). The 'cleavage" occurs between the glycine and proline residues found on the C-terminus of the 2A peptide. Exemplary 2A peptides include, but are not limited to, the 2A peptides encoded by Thosea asigna virus (TaV), equine rhinitis A virus (ERAV), porcine teschovirus-1 (PTVI) and foot and mouth disease virus (FMDV), or modified versions thereof In particular examples herein, the 2A peptide comprises PTVI 2A (P2A), FMDV 2A (F2A), ERAV 2A (E2A) or TaV 2A (T2A), the sequences of which are show below and are set forth herein as SEQ ID NOs: 14-17.

P2A: ATNFSLLKQAGDVEENPGP (SEQ ID NO: 14) F2A: VKQTLNFDLLKLAGDVESNPGP (SEQ ID NO: 15) E2A: QCTNYALLKLAGDVESNPGP (SEQ ID NO: 16) T2A: EGRGSLLTCGDVEENPGP (SEQ ID NO: 17)

In some examples, the 2A peptide is modified to include Gly-Ser-Gly at the N-terminus to improve cleavage efficiency. The sequences of modified P2A, F2A, E2A and T2A are shown below and are set forth herein as SEQ ID NOs: 14-17.

Modified P2A: GSGATNFSLLKQAGDVEENPGP (SEQ ID NO: 18) Modified F2A: GSGVKQTLNFDLLKLAGDVESNPGP (SEQ ID NO: 19) Modified E2A: GSGQCTNYALLKLAGDVESNPGP (SEQ ID NO: 20) Modified T2A: GSGEGRGSLLTCGDVEENPGP (SEQ ID NO: 21)

In some embodiments, the 2A polypeptide is a variant of a 2A polypeptide disclosed herein. Variants can include polypeptide sequences having at least 80%, at least 85%, at least 90%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or more, sequence identity to a wild-type or modified 2A polypeptide disclosed herein. Variants can include, for example, a deletion of at least one N-terminal amino acid from the 2A polypeptide of any one of SEQ ID NOs: 14-21, for example a deletion of 1, 2, 3, 4 or 5 amino acids, including ranges between any two of the listed values. Variants can include a deletion of at least one C-terminal amino acid from the 2A polypeptide of any one of

SEQ ID NOs: 14-21, for example a deletion of 1, 2, 3, 4 or 5 amino acids, including ranges between any two of the listed values. Variants can also include, for example, at least 1, 2, 3, 4 or 5 amino acid substitutions, such as conservative amino acid substitutions.

VI. Pharmaceutical Compositions Provided herein are compositions comprising a recombinant adenovirus or a recombinant adenovirus genome. The compositions are, optionally, suitable for formulation and administration in vitro or in vivo. Optionally, the compositions comprise one or more of the provided agents and a pharmaceutically acceptable carrier. Suitable carriers and their formulations are described in Remington: The Science and PracticeofPharmacy, 2 2 ndEdition, Loyd V. Allen et al., editors, Pharmaceutical Press (2012). Pharmaceutically acceptable carriers include materials that are not biologically or otherwise undesirable, i.e., the material is administered to a subject without causing undesirable biological effects or interacting in a deleterious manner with the other components of the pharmaceutical composition in which it is contained. If administered to a subject, the carrier is optionally selected to minimize degradation of the active ingredient and to minimize adverse side effects in the subject.

The recombinant viruses (or one or more nucleic acids or vectors encoding the recombinant adenovirus) are administered in accord with known methods, such as intravenous administration, e.g., as a bolus or by continuous infusion over a period of time, by intramuscular, intraperitoneal, ) intracerobrospinal, subcutaneous, intra-articular, intrasynovial, intrathecal, oral, topical, intratumoral or inhalation routes. The administration may be local or systemic. The compositions can be administered via any of several routes of administration, including topically, orally, parenterally, intravenously, intra-articularly, intraperitoneally, intramuscularly, subcutaneously, intracavity, transdermally, intrahepatically, intracranially, nebulization/inhalation, or by installation via

bronchoscopy. Thus, the compositions are administered in a number of ways depending on whether local or systemic treatment is desired, and on the area to be treated. In some embodiments, the compositions for administration will include a recombinant adenovirus (or recombinant genome) as described herein dissolved in a pharmaceutically acceptable carrier, preferably an aqueous carrier. A variety of aqueous carriers can be used, e.g., buffered saline ) and the like. These solutions are sterile and generally free ofundesirable matter. These compositions may be sterilized by conventional, well known sterilization techniques. The compositions may contain pharmaceutically acceptable auxiliary substances as required to approximate physiological conditions such as pH adjusting and buffering agents, toxicity adjusting agents and the like, for example, sodium acetate, sodium chloride, potassium chloride, calcium chloride, sodium lactate and the like. The concentration of active agent in these formulations can vary widely, and will be selected primarily based on fluid volumes, viscosities, body weight and the like in accordance with the particular mode of administration selected and the subject's needs. Pharmaceutical formulations, particularly, of the recombinant viruses can be prepared by mixing the recombinant adenovirus (or one or more nucleic acids encoding the recombinant adenovirus) having the desired degree of purity with optional pharmaceutically acceptable carriers, excipients or stabilizers. Such formulations can belyophilized formulations or aqueous solutions. Acceptable carriers, excipients, or stabilizers are nontoxic to recipients at the dosages and concentrations used. Acceptable carriers, excipients or stabilizers can be acetate, phosphate, citrate, and other organic acids; antioxidants (e.g., ascorbic acid) preservatives, low molecular weight polypeptides; proteins, such as serum albumin or gelatin, or hydrophilic polymers such as polyvinylpyllolidone; and amino acids, monosaccharides, disaccharides, and other carbohydrates including glucose, mannose, or dextrins; chelating agents; and ionic and non-ionic surfactants (e.g., polysorbate); salt-forming counter-ions such as sodium; metal complexes (e.g. Zn-protein complexes); and/or non-ionic surfactants. The recombinant adenovirus (or one or more nucleic acids encoding the recombinant adenovirus) can be formulated at any appropriate concentration of infectious units. Formulations suitable for oral administration can consist of (a) liquid solutions, such as an ) effective amount of the recombinant adenovirus suspended in diluents, such as water, saline or PEG 400; (b) capsules, sachets or tablets, each containing a predetermined amount of the active ingredient, as liquids, solids, granules or gelatin; (c) suspensions in an appropriate liquid; and (d) suitable emulsions. Tablet forms can include one or more of lactose, sucrose, mannitol, sorbitol, calcium phosphates, corn starch, potato starch, microcrystalline cellulose, gelatin, colloidal silicon dioxide, talc, magnesium stearate, stearic acid, and other excipients, colorants, fillers, binders, diluents, buffering agents, moistening agents, preservatives, flavoring agents, dyes, disintegrating agents, and pharmaceutically compatible carriers. Lozenge forms can comprise the active ingredient in a flavor, e.g., sucrose, as well as pastilles comprising the active ingredient in an inert base, such as gelatin and glycerin or sucrose and acacia emulsions, gels, and the like containing, in addition to the active ) ingredient, carriers known in the art. The recombinant adenovirus (or one or more nucleic acids encoding the recombinant adenovirus), alone or in combination with other suitable components, can be made into aerosol formulations (i.e., they can be "nebulized") to be administered via inhalation. Aerosol formulations can be placed into pressurized acceptable propellants, such as dichlorodifluoromethane, propane, nitrogen, and the like. Formulations suitable for parenteral administration, such as, for example, by intraarticular (in thejoints), intravenous, intramuscular, intratumoral, intradermal, intraperitoneal, and subcutaneous routes, include aqueous and non-aqueous, isotonic sterile injection solutions, which can contain antioxidants, buffers, bacteriostats, and solutes that render the formulation isotonic with the blood of the intended recipient, and aqueous and non-aqueous sterile suspensions that can include suspending agents, solubilizers, thickening agents, stabilizers, and preservatives. In the provided methods, compositions can be administered, for example, by intravenous infusion, orally, topically, intraperitoneally, intravesically intratumorally, or intrathecally. Parenteral administration, intratumoral administration, and intravenous administration are the preferred methods of administration. The formulations of compounds can be presented in unit-dose or multi-dose sealed containers, such as ampules and vials. Injection solutions and suspensions can be prepared from sterile powders, granules, and tablets of the kind previously described. Cells transduced or infected by adenovirus or transfected with nucleic acids for ex vivo therapy can also be administered intravenously or parenterally as described above. In some examples, the pharmaceutical preparation is in unit dosage form. In such form the ) preparation is subdivided into unit doses containing appropriate quantities of the active component. Thus, the pharmaceutical compositions can be administered in a variety of unit dosage forms depending upon the method of administration. For example, unit dosage forms suitable for oral administration include, but are not limited to, powder, tablets, pills, capsules and lozenges.

VII. Methods of Treatment The recombinant adenoviruses, recombinant adenovirus genomes and compositions disclosed herein can be administered for therapeutic or prophylactic treatment. In particular, provided are methods of reducing or inhibiting tumor cell viability or growth in a subject, reducing or inhibiting tumor progression in a subject, reducing the number of metastases, reducing the size and/or volume of a metastasis, reducing tumor size and/or volume in a subject and/or treating cancer in a subject. The methods include administering a therapeutically effective amount of a recombinant adenovirus or recombinant adenovirus genome (or composition thereof) to the subject. As described throughout, the adenovirus or pharmaceutical composition is administered in any number of ways including, but not limited to, intravenously, intravascularly, intrathecally, intramuscularly, subcutaneously, intratumorally, intraperitoneally, or orally. Optionally, the method further comprising administering to the subject one or more additional therapeutic agents, such as a chemotherapeutic agent, biologic, and/or radiation. In some embodiments, the cancer or tumor is a lung, prostate, colorectal, breast, thyroid, renal, pancreas, bone, head and neck, or liver cancer or tumor, or is a type of leukemia. In some cases, the cancer is metastatic. In some examples, the tumor is a tumor of the mammary, pituitary, thyroid, or prostate gland; a tumor of the brain, liver, meninges, bone, ovary, uterus, or cervix; monocytic or myelogenous leukemia; adenocarcinoma, adenoma, astrocytoma, bladder tumor, brain tumor, Burkitt's lymphoma, breast carcinoma, cervical carcinoma, colon carcinoma, kidney carcinoma, liver carcinoma, lung carcinoma, ovarian carcinoma, pancreatic carcinoma, prostate carcinoma, rectal carcinoma, skin carcinoma, stomach carcinoma, testis carcinoma, thyroid carcinoma, chondrosarcoma, choriocarcinoma, fibroma, fibrosarcoma, glioblastoma, glioma, hepatoma, histiocytoma, leiomyoblastoma, leiomyosarcoma, lymphoma, liposarcoma cell, mammary tumor, medulloblastoma, myeloma, plasmacytoma, neuroblastoma, neuroglioma, osteogenic sarcoma, pancreatic tumor, pituitary tumor, retinoblastoma, rhabdomyosarcoma, sarcoma, testicular tumor, thymoma, or Wilms tumor. Tumors include both primary and metastatic solid tumors, including carcinomas of breast, colon, rectum, lung, oropharynx, hypopharynx, esophagus, stomach, pancreas, liver, gallbladder and bile ducts, small intestine, urinary tract (including kidney, bladder and urothelium), female genital tract, (including cervix, uterus, and ovaries as well as choriocarcinoma and gestational trophoblastic disease), male genital tract (including prostate, seminal vesicles, testes and germ cell tumors), endocrine glands (including the thyroid, adrenal, and pituitary glands), and skin, as well as hemangiomas, melanomas, sarcomas (including those arising from bone and soft tissues as well as Kaposi's sarcoma) and tumors of the brain, nerves, eyes, and meninges (including astrocytomas, gliomas, glioblastomas, retinoblastomas, neuromas, neuroblastomas, Schwannomas, and meningiomas). In some aspects, solid tumors may be treated that arise from hematopoietic malignancies such as leukemias (i.e. chloromas, plasmacytomas and the plaques and tumors of mycosis fungoides and cutaneous T-cell lymphoma/leukemia) as well as in the treatment of ) lymphomas (both Hodgkin's and non-Hodgkin's lymphomas). In addition, treatments may be useful in the prevention of metastases from the tumors described herein.

In therapeutic applications, recombinant adenoviruses or compositions thereof are administered to a subject in a therapeutically effective amount or dose. Amounts effective for this use will depend upon the severity of the disease and the general state of the patient's health. Single or multiple administrations of the compositions may be administered depending on the dosage and frequency as required and tolerated by the patient. A "patient" or "subject" includes both humans and other animals, particularly mammals. Thus, the methods are applicable to both human therapy and veterinary applications, such as mice, rats, rabbits, cats, dogs, cows, horses, pigs, chickens, and the like. An effective amount of an adenovirus having a modified sequence is determined on an individual basis and is based, at least in part, on the particular recombinant adenovirus used; the individual's size, age, gender; and the size and other characteristics of the proliferating cells. For example, for treatment of a human, at least 103 plaque forming units (PFU) of a recombinant virus is used, such as at least 104, at least 10 5, at least 106, at least 107, at least 108, at least 10 9, at least 100, at least 101, or at least 1012PFU, for example approximately 10' to 1012 PFU of a recombinant virus is used, depending on the type, size and number of proliferating cells or neoplasms present. The effective amount can be from about 1.0 pfu/kg body weight to about 10" pfu/kg body weight (e.g., from about 102 pfu/kg body weight to about 1013 pfu/kg body weight). A recombinant adenovirus is administered in a single dose or in multiple doses (e.g., two, three, four, six, or more doses). Multiple doses can be administered concurrently or consecutively (e.g., over a period of days or weeks). In some embodiments, the provided methods include administering to the subject one or more additional therapeutic agents, such as an anti-cancer agent or other therapeutic treatment (such as surgical resection of the tumor). Exemplary anti-cancer agents include, but are not limited to, chemotherapeutic agents, such as, for example, mitotic inhibitors, alkylating agents, anti-metabolites, intercalating antibiotics, growth factor inhibitors, cell cycle inhibitors, enzymes, topoisomerase inhibitors, anti-survival agents, biological response modifiers, anti-hormones (e.g. anti-androgens), anti-angiogenesis agents and CDK inhibitors. Other anti-cancer treatments include radiation therapy and other antibodies that specifically target cancer cells. Non-limiting examples of alkylating agents include nitrogen mustards (such as mechlorethamine, cyclophosphamide, melphalan, uracil mustard or chlorambucil), alkyl sulfonates ) (such as busulfan), nitrosoureas (such as carmustine, lomustine, semustine, streptozocin, or dacarbazine).

Non-limiting examples of antimetabolites include folic acid analogs (such as methotrexate), pyrimidine analogs (such as 5-FU or cytarabine), and purine analogs, such as mercaptopurine or thioguanine. Non-limiting examples of natural products include vinca alkaloids (such as vinblastine, vincristine, or vindesine), epipodophyllotoxins (such as etoposide or teniposide), antibiotics (such as dactinomycin, daunorubicin, doxorubicin, bleomycin, plicamycin, or mitomycin C), and enzymes (such as L-asparaginase). Non-limiting examples of miscellaneous agents include platinum coordination complexes (such as cis-diamine-dichloroplatinum II also known as cisplatin), substituted ureas (such as hydroxyurea), methyl hydrazine derivatives (such as procarbazine), and adrenocrotical suppressants (such as mitotane and aminoglutethimide). Non-limiting examples of hormones and antagonists include adrenocorticosteroids (such as prednisone), progestins (such as hydroxyprogesterone caproate, medroxyprogesterone acetate, and magestrol acetate), estrogens (such as diethylstilbestrol and ethinyl estradiol), antiestrogens (such as tamoxifen), and androgens (such as testerone proprionate and fluoxymesterone). Examples of the most commonly used chemotherapy drugs include Adriamycin, Alkeran, Ara C, BiCNU, Busulfan, CCNU, Carboplatinum, Cisplatinum, Cytoxan, Daunorubicin, DTIC, 5-FU, Fludarabine, Hydrea, Idarubicin, Ifosfamide, Methotrexate, Mithramycin, Mitomycin, Mitoxantrone, Nitrogen Mustard, Taxol (or other taxanes, such as docetaxel), Velban, Vincristine, VP-16, while some more newer drugs include Gemcitabine (Gemzar), Herceptin, Irinotecan (Camptosar, CPT-11), Leustatin, Navelbine, Rituxan STI-571, Taxotere, Topotecan (Hycamtin), Xeloda (Capecitabine), Zevelin and calcitriol. Non-limiting examples of immunomodulators that can be used include AS-101 (Wyeth-Ayerst Labs.), bropirimine (Upjohn), gamma interferon (Genentech), GM-CSF (granulocyte macrophage colony stimulating factor; Genetics Institute), IL-2 (Cetus or Hoffman-LaRoche), human immune globulin (Cutter Biological), IMREG (from Imreg of New Orleans, La.), SK&F 106528, and TNF (tumor necrosis factor; Genentech). CDK (Cyclin-dependent kinase) inhibitors are agents that inhibit the function of CDKs. Non limiting examples of CDK inhibitors for use in the provided methods include AG-024322, AT7519, AZD5438, flavopiridol, indisulam, P1446A-05, PD-0332991, and P276-00 (see e.g., Lapenna et al., Nature Reviews, 8:547-566, 2009). Other CDK inhibitors include LY2835219, Palbociclib, LEE011

(Novartis), pan-CDK inhibitor AT7519, seliciclib, CYC065, butyrolactone , hymenialdisine, SU9516, CINK4, PDO183812 or fascaplysin. In some examples, the CDK inhibitor is a broad-range inhibitor (such as flavopiridol, olomoucine, roscovitine, kenpaullone, SNS-032, AT7519, AG-024322, (S)-Roscovitine or R547). In other examples, the CDK inhibitor is a specific inhibitor (such as fascaplysin, ryuvidine, purvalanol A, NU2058, BML-259, SU 9516, PD0332991 or P-276-00). In some embodiments, the provided methods further include administering to the subject a therapeutically effective amount of an immunotherapy. Non-limiting examples of immunomodulators that can be used include AS-101 (Wyeth-Ayerst Labs.), bropirimine (Upjohn), gamma interferon (Genentech), GM-CSF (granulocyte macrophage colony stimulating factor; Genetics Institute), IL-2 (Cetus or Hoffman-LaRoche), human immune globulin (Cutter Biological), IMREG (from Imreg of New Orleans, La.), SK&F 106528, and TNF (tumor necrosis factor; Genentech). The immunotherpautic agent can be a PD-i antagonist or a PD-Li antagonist, such as an antibody that specifically binds PD-i or PD-L, such as Atezolizumab, MPDL3280A, BNS-936558 (Nivolumab), Pembrolizumab, Pidilizumab, CTO11, AMP-224, AMP-514, MEDI-0680, BMS-936559, BMS935559, MEDI-4736, MPDL-3280A, MSB-0010718C. The immunotherpautic agent can also be a CTLA-4, LAG-3, or B7-H3 antagonist, such as Tremelimumab, BMS-986016, and MGA271. In some embodiments, the provided methods further include administering to the subject a therapeutically effective amount of one or more anti-angiogenic agents, such as proteins, enzymes, ) polysaccharides, oligonucleotides, DNA, RNA, and recombinant vectors, and small molecules that function to reduce or even inhibit blood vessel growth. Examples of suitable angiogenesis inhibitors include, without limitation, angiostatin K1-3, staurosporine, genistein, fumagillin, medroxyprogesterone, suramin, interferon-alpha, metalloproteinase inhibitors, platelet factor 4, somatostatin, thromobospondin, endostatin, thalidomide, and derivatives and analogs thereof. For example, in some embodiments the anti-angiogenesis agent is an antibody that specifically binds to VEGF (e.g., AVASTIN@, Roche) or a VEGF receptor (e.g., a VEGFR2 antibody). In one example the anti-angiogenic agent includes a VEGFR2 antibody, or DMXAA (also known as Vadimezan or ASA404; available commercially, e.g., from Sigma Corp., St. Louis, MO) or both. The anti angiogenic agent can be bevacizumab, sunitinib, an anti-angiogenic tyrosine kinase inhibitors (TKI), ) such as sunitinib, xitinib and dasatinib. These can be used individually or in any combination. In some embodiments, the provided methods further include administering to the subject a therapeutically effective amount of one or more kinase inhibitors, such as GLEEVAC@, IRESSA@, and TARCEVA®, sunitinib, sorafenib, anitinib, and dasatinib that prevent phosphorylation and activation of growth factors. Antibodies that can be used include HERCEPTIN@ and AVASTIN@ that block growth factors and the angiogenic pathway. These can be used individually or in combination. In some embodiments, the provided methods further include administering to the subject a therapeutically effective amount of one or more therapeutic monoclonal antibodies, for example, 3F8, Abagovomab, Adecatumumab, Afutuzumab, Alacizumab, Alemtuzumab, Altumomab pentetate, Anatumomab mafenatox, Apolizumab, Arcitumomab, Bavituximab, Bectumomab, Belimumab, Besilesomab, Bevacizumab, Bivatuzumab mertansine, Blinatumomab, Brentuximab vedotin, Cantuzumab mertansine, Capromab pendetide, Catumaxomab, CC49, Cetuximab, Citatuzumab bogatox, Cixutumumab, Clivatuzumab tetraxetan, Conatumumab, Dacetuzumab, Detumomab, Ecromeximab, Eculizumab, Edrecolomab, Epratuzumab, Ertumaxomab, Etaracizumab, Farletuzumab, Figitumumab, Galiximab, Gemtuzumab ozogamicin, Girentuximab, Glembatumumab vedotin, Ibritumomab tiuxetan, Igovomab, Imciromab, Intetumumab, Inotuzumab ozogamicin, Ipilimumab, Iratumumab, Labetuzumab, Lexatumumab, Lintuzumab, Lorvotuzumab mertansine, Lucatumumab, Lumiliximab, Mapatumumab, Matuzumab, Mepolizumab, Metelimumab, Milatuzumab, Mitumomab, Morolimumab, Nacolomab tafenatox, Naptumomab estafenatox, Necitumumab, Nimotuzumab, Nofetumomab merpentan, Ofatumumab, Olaratumab, Oportuzumab monatox, Oregovomab, Panitumumab, Pemtumomab, Pertuzumab, Pintumomab, Pritumumab, Ramucirumab, Rilotumumab, Rituximab, Robatumumab, Satumomab pendetide, Sibrotuzumab, Sonepcizumab, Tacatuzumab tetraxetan, Taplitumomab paptox, Tenatumomab, TGN1412, Ticilimumab (tremelimumab), Tigatuzumab, TNX-650, Trastuzumab, Tremelimumab, Tucotuzumab celmoleukin, Veltuzumab, Volociximab, Votumumab, or Zalutumumab. In some examples, the heterologous ORF encodes one of these therapeutic antibodies. Another common treatment for some types of cancer is surgical treatment, for example surgical resection of the cancer or a portion of it. Another example of a treatment is radiotherapy, for example administration of radioactive material or energy (such as external beam therapy) to the tumor site to help eradicate the tumor or shrink it prior to surgical resection. The choice of agent and dosage can be determined readily by one of skill in the art based on the given disease being treated. Combinations of agents or compositions can be administered either ) concomitantly (e.g., as a mixture), separately but simultaneously (e.g., via separate intravenous lines) or sequentially (e.g., one agent is administered first followed by administration of the second agent).

Thus, the term combination is used to refer to concomitant, simultaneous or sequential administration of two or more agents or compositions. According to the methods disclosed herein, the subject is administered an effective amount of one or more of the agents provided herein. The effective amount is defined as any amount necessary to produce a desired physiologic response (e.g., killing of a cancer cell). Therapeutic agents are typically administered at the initial dosage of about 0.001 mg/kg to about 1000 mg/kg daily. A dose range of about 0.01 mg/kg to about 500 mg/kg, or about 0.1 mg/kg to about 200 mg/kg, or about 1 mg/kg to about 100 mg/kg, or about 10 mg/kg to about 50 mg/kg, can be used. The dosages, however, may be varied depending upon the requirements of the subject, the severity of the condition being treated, and the compound being employed. For example, dosages can be empirically determined considering the type and stage of cancer diagnosed in a particular subject. The dose administered to a subject, in the context of the provided methods should be sufficient to affect a beneficial therapeutic response in the patient over time. Determination of the proper dosage for a particular situation is within the skill of the practitioner. Thus, effective amounts and schedules for administering the agent may be determined empirically by one skilled in the art. The dosage should not be so large as to cause substantial adverse side effects, such as unwanted cross-reactions, anaphylactic reactions, and the like.

The dosage can be adjusted by the individual physician in the event of any contraindications. Guidance can be found in the literature for appropriate dosages for given classes of pharmaceutical products. Provided herein is a method of inhibiting tumor cell viability or growth by contacting the tumor cell with a recombinant adenovirus, a recombinant adenovirus genome, or composition thereof, as disclosed herein. In some embodiments, the method is an in vitro method. In other embodiments, the method is an in vivo method and contacting the tumor cell comprises administering the recombinant adenovirus, recombinant adenovirus genome or composition to a subject with a tumor.

Further provided is a method of inhibiting tumor progression or reducing tumor volume in a subject, by administering to the subject a therapeutically effective amount of a recombinant adenovirus or recombinant adenovirus genome (or composition thereof) disclosed herein. Also provided is a method of treating cancer in a subject, by administering to the subject a therapeutically effective amount of a recombinant adenovirus or recombinant adenovirus genome (or ) composition thereof) disclosed herein.

VIII. Adsembly and AdSLIC The adenovirus genome is organized into several functional groups, labeled El, E2, E3, E4, and Li-5. The El region encodes proteins that control the transcription of all other viral genes and induces S-phase in the host cell. The E2 region encodes proteins that drive viral DNA replication. The E3 region proteins modulate host cell immune response and are dispensable in cell culture. The E4 region contains genes for a disparate set of functions. And the Li-5 region encodes the viral particle structural proteins. Taking advantage of this natural segregation of functionality, the inventors previously developed a method of recombinant adenovirus assembly that allows quick and easy manipulation of the 36kb Ad genome by separating it into 4 plasmids, El, E3, E4, and Core, as shown in FIG. 6A (Adsembly and AdSLIC; see WO 2012/024351, which is incorporated herein by reference). Because of their more reasonable size, manipulation of these smaller plasmids is straightforward using standard techniques. Adsembly and AdSLIC enable the combinatorial in vitro assembly of adenoviruses with novel properties from compatible genomic library parts in 4 hours. Adsembly and AdSLIC provide a common genome design platform that enables synthetic viruses with novel properties to be assembled using four libraries of functional parts (FIG. 6A). These libraries of parts can be re-assembled in all possible combinations using either multi-site specific recombination sites (Adsembly; FIG. 6B) or sequence independent seamless cloning (AdSLIC; FIG. 6C). The Adsembly and AdSLIC technologies enable the modular design and production of adenoviruses with unique capabilities. Developing the capability to design, manufacture, and test viruses in an automated, high-throughput manner will accelerate and expand the development of new viruses for therapeutic, diagnostic, and research studies. While the cloning step was once the bottleneck for producing new viral constructs, the advent of Adsembly and AdSLIC have made it such that the ability to construct viral genomes has outpaced the ability to test them. An equally high throughput kinetics assay is critical to exploit the full potential and high content assembly of synthetic and personalized viral therapies and diagnostics using the Adsembly and AdSLIC methods.

The following examples are provided to illustrate certain particular features and/or embodiments. These examples should not be construed to limit the disclosure to the particular features or embodiments described.

EXAMPLES Example 1: Identification of optimal locations in the adenovirus genome for exogenous ORFs This example describes the identification of specific locations within the adenovirus genome where exogenous ORFs can be inserted, along with a self-cleaving peptide sequence, without disrupting virus kinetics. The insertion of exogenous genes in adenovirus vectors is limited by the size capacity of the adenovirus capsid. Excessive addition of exogenous nucleic acid leads to incomplete genome loading into the capsid and reduced viral kinetics. A solution to the challenge presented by the limited available space in the adenovirus genome is to locate exogenous open reading frames (ORFs) as fusion products within native adenovirus ORFs. This strategy makes use of adenovirus promoters, 5'UTRs, and polyA tails already encoded in the genome. However, expression of a fusion between a native adenovirus protein and an exogenous protein can be deleterious to one or both protein functions and lead to a significant decrease in adenovirus replication kinetics. In fact, studies disclosed herein demonstrate that direct fusion of an exogenous ORF to the adenovirus ElA, DNA polymerase or ADP ORFs significantly inhibits adenovirus replication kinetics. In addition, the inventors previously tried using an internal ribosomal entry site (IRES) to insert exogenous ORFs, which also failed to produce recombinant virus with wild-type kinetics. This example describes a solution to this problem by using a self-cleaving peptide sequence placed between the native adenovirus ORF and the exogenous ORF. When placed between the two ) ORFs on a single mRNA, the presence of the self-cleaving peptide sequence leads to ribosome skipping and release of the first protein separate from the second protein. The adenovirus constructs generated in this example use the self-cleaving peptide P2A and a fluorescent protein (e.g. YPet, mCherry) as the heterologous ORF. The table below provides a list of the constructs that were generated and indicates the expression level of the exogenous ORF (low, medium or high) and the level of virus replication kinetics (low, medium or high) in two different cells lines (293-E4 cells and A549 cells).

Construct Designation SEQ ID Expression Kinetics in Kinetics in NO: Level 293-E4 cells A549 cells YPet-GS-E1A CMBT-352 Low High Low YPet-P2A-E1A CMBT-379 1 High High Medium

Construct Designation SEQ ID Expression Kinetics in Kinetics in NO: Level 293-E4 cells A549 cells E1A-P2A-YPet CMBT-432 2 Medium High Medium ElA-P2A-YPet-PEST CMBT-569 Medium High Medium E1A-P2A-mCherry CMBT-455 Medium High Medium E1B-55k-P2A-YPet CMBT-456 3 High High High E1B-55k-P2A-mCherry CMBT-499 4 High High High YPet-P2A-(DNA Poly) CMBT-530 5 Medium High High YPet-(DNA Poly) CMBT-590 Medium None Not tested DBP-GS-BFP CMBT-612 High High Not tested DBP-P2A-YPet CMBT-886 6 High High High mCherry-GS-ADP CMBT-402 High Medium Not tested AADP[mCherry] CMBT-599 High High Medium YPet-P2A-ADP CMBT-403 7 High High High ADP-P2A-YPet CMBT-429 8 High Low None E3-14.7k-P2A-YPet PCMN-887 9 High High High Fiber-GS-mCherry CMBT-368 High Medium None Fiber-GS-tdTomato CMBT-369 High None Not tested YPet-P2A-Fiber CMBT-407 12 High None Not tested Fiber-P2A-YPet CMBT-445 13 Very High Medium None Fiber-P2A-BFP CMBT-632 Very High Medium None Fiber-GS-P2A-YPet CMBT-446 Very High Medium None YPet-P2A-E4-ORF2 CMBT-457 10 Medium High High mCherry-P2A-E4-ORF2 CMBT-633 11 Medium High High

Constructs exhibiting "high" replication kinetics (i.e. replication kinetics that are comparable to wild-type adenovirus) in both cell types are considered candidates for generating therapeutic adenovirus constructs (show in bold). In addition, the fiber-P2A-heterologous ORF constructs exhibited significant defects in viral replication, but generated extraordinarily high levels of expression of the heterologous protein. Thus, these fiber constructs also can be used in therapeutic applications for production of high levels of a therapeutic protein in the context of a replication defective adenovirus.

Comparison of direct fusion and insertion of a P2A site Several constructs were generated in which a fluorescent protein was fused directly to an adenovirus ORE In particular, the following direct fusions were generated: YPet-EA, YPet-(DNA polymerase) and mCherry-ADP. YPet-E1A adenovirus exhibited a significant impairment in virus kinetics. Insertion of the P2A site between YPet and E1A (YPet-P2A-E1A) improved virus kinetics, but did not restore virus kinetics to wild-type level. Another construct was then generated to test fusion of P2A and YPet to the C terminal end of ElA (E1A-P2A-YPet). This construct further improved virus kinetics, but again did not restore kinetics to the level of wild-type adenovirus. Multiple attempts at transfecting the YPet-(DNA-poly) genome plasmid failed to produce viable virus (no plaques were formed). However, fusion of YPet-P2A to the N-terminus of DNA polymerase (YPet-P2A-(DNA poly)) produced a virus with wild-type kinetics, as shown in the table above. In addition, the direct fusion of mCherry to ADP (mCherry-ADP) produced a virus with significantly impaired kinetics. However, insertion of the P2A site between the mCherry ORF and the ADP ORF resulted in a virus with wild-type kinetics (mCherry-P2A-ADP). The same result was obtained using a different fluorescent protein; the YPet-P2A-ADP construct exhibited wild-type virus kinetics. However, placement of P2A and the heterologous ORF on the C-terminal side of ADP produced a virus that did not replicate. Thus, for ADP, the heterologous ORF must be placed at the N terminus. Both direct fusion to fiber and insertion of a P2A site between fiber and a heterologous ORF produced viruses with significantly impaired replication kinetics. However, the recombinant adenoviruses comprising fiber-P2A-heterologous ORF exhibited extraordinarily high expression levels of the heterologous protein (YPet or blue fluorescent protein (BFP) in this example).

Additional constructs with wild-type virus kinetics FIG. 7 shows a comparison of Ln-Slope of six different constructs: YPet-EA, YPet-P2A-E1A, E1A-P2A-mCherry, E1B-55k-P2A-YPet, YPet-P2A-ADP and Fiber-P2A-YPet. As discussed above, direct fusion of YPet to E1A produced a virus with significantly impaired kinetics, and addition of the

P2A site at either the N-terminus (YPet-P2A-E1A) or the C-terminus (EA-P2A-mCherry) improved virus kinetics but not to wild-type levels. However, inserting the P2A site and a heterologous ORF at the C-terminus of E1B-55k (E1B-55k-P2A-YPet) or the N-terminus of ADP (YPet-P2A-ADP) generated a recombinant virus with wild-type virus kinetics. Evaluation of viral kinetics for constructs having a P2A site and heterologous ORF on the C terminus of DBP (DBP-P2A-YPet) or the C-terminus of E3-14.7k (E3-14.7k-P2A-YPet), or having a P2A site and heterologous ORF on the N-terminus of E4-ORF2 (YPet-P2A-E4-ORF2 and mCherry P2A-E4-ORF2) produced viruses with wild-type replication kinetics. The results of these data demonstrate that at least the following adenovirus genome constructs can be used to develop therapeutic adenovirus constructs: ElB-55k-P2A-heterologous ORF heterologous ORF-P2A-(DNA polymerase) DBP-SC-heterologous ORF heterologous ORF-SC-ADP E3-14.7k-SC-heterologous ORF heterologous ORF-P2A-E4-ORF2 fiber-P2A-heterologous ORF

For therapeutic applications, the heterologous ORF encodes a therapeutic protein.

Other adenovirus serotypes Previously described methods of measuring viral kinetics are all highly dependent upon cell type specific assays and are thus serotype specific due to the divergent tropism of each adenovirus serotype. The adenovirus kinetic assay disclosed herein is not dependent upon any one cell type and so can be extended to serotypes other than Ad5. All adenovirus serotypes contain an ORF equivalent to Ad5 E3-14.7k. Therefore, viruses equivalent to Ad5 E3-14.7k-P2A-YPet (PCMN-887; SEQ ID NO: 9) were generated using Ad9 (containing E3-15k) and Ad34 (containing E3-14.8k): PCMN-888 (Ad9 E3-15k-P2A-YPet; SEQ ID NO: 22) and PCMN-889 (Ad34 E3-14.8k-P2A-YPet; SEQ ID NO: 23). Chimeric viruses containing the Ad5 core and a fiber shaft and knob from either Ad9 or Ad34 were ) also generated. The four recombinant viruses were then tested in the FBVK assay using 293 cells (FIG. 9A), A549 cells (FIG. 9B) and U2OS cells (FIG. 9C). All four recombinant viruses exhibited high levels of YPet expression with minimal impact on viral kinetics resulting from insertion of the exogenous ORF.

Example 2: Methods for evaluating adenovirus replication kinetics The Adsembly and AdSLIC methods for assembling recombinant adenoviruses provide a means for generating large numbers of recombinant virus genomes and viruses in a short period of time. However, a need exists for a rapid and high-throughput method for evaluating replication kinetics of recombinant adenoviruses designed for clinical and therapeutic use. This example describes a fluorescence-based viral kinetics assay that can be used to test virus replication kinetics of recombinant adenoviruses (FIG. 3). The assay can be performed with either recombinant adenovirus genome plasmids or recombinant adenovirus particles as the starting material. When starting with a recombinant adenovirus genome, the assay includes transfecting cells with adenovirus genome plasmids (such as those described above in Example 1) and monitoring fluorophore expression over time (FIGS. 4A-4B). Transfection conditions are selected such that about 5-10% of the cells are initially transfected. Cells that are not initially transfected are available for secondary infection by virus particles produced from the initial transfection. Log-slope is used as a measure of kinetics based on secondary, tertiary, and quarternary (etc.) infections, thus it is not necessary to know the percentage of cells that are initially transfected. FIGS. 4A and 4B show an exemplary virus-based kinetics assay starting with recombinant adenovirus genome plasmids. In this ) example, a 48-well plate is used, which allows for testing of 14 different virus constructs (in triplicate) simultaneously. The upper half of the 48-well plate (FIG. 4A) includes triplicate wells of six different viruses, 3 mock-infected wells and 3 "blank" wells with FLUORESBRITET" beads, which compensate for tool sensitivity drift. The lower half of the 48-well plate (FIG. 4B) includes triplicate wells of eight different virus constructs. Once cells are transfected, the plate is placed in a TECANTM plate reader for continuous fluorescence monitoring. The data collected is used to calculate In-slope for each construct (FIG. 8). The assay can also be carried out by infecting cells with recombinant virus particles. In this version of the assay, cells are infected with recombinant virus particles and fluorophore expression is monitored over time (FIG. 5). As with the genome plasmid version of the assay, it is not necessary to ) know the exact titer of the starting virus stock. Typically, a dilution series is used for initial infection, such as a dilution series ranging from 1:100 to 1:218,700, as shown in FIG. 5. A dilution of 1:100 generally leads to infection of all cells, whereas a dilution of 1:218,700 generally leads to initial infection of very few cells. In this example, a 96-well plate is used and11 different virus constructs are tested simultaneously at eight different dilutions (1:100, 1:300, 1:900, 1:2700, 1:8100, 1:24,300, 1:72,900 and 1:218,700). The plate also includes four wells of mock-infected cells and four wells of FLUORESBRITETM beads. Once the cells are infected, the plate is placed in a TECANTMplatereader for continuous fluorescence monitoring. The data collected is used to calculate In-slope for each construct (FIG. 8). The TECANTM plate readers also provide incubation functions (maintaining an appropriate temperature as well as CO2 and 02 levels). Data points are taken every 15 minutes to calculate the In slope. Using these methods, it is possible to rapidly and efficiently compare the kinetics between a number of different viruses and between different cell types. For example, to evaluate whether particular recombinant adenoviruses could be used therapeutically as oncolytic viruses, this assay could be employed to find viruses that exhibit high replication kinetics in tumor cells, but slow virus kinetics in non-tumor cells. Furthermore, the virus kinetics of the recombinant viruses can be evaluated by infecting or transfecting the tumor cell type of interest in this assay.

Calculating log-slope To measure log-slope, the linear plot of fluorescence intensity versus time is converted to a semi-log plot by taking the natural logarithm of the measured fluorescence intensity at each time point. Since the fluorescence intensity exhibits exponential growth during viral replication, this conversion results in a straight line when plotting ln(fluorescence intensity) vs. time. This straight line is then fit using standard least-squares methods. The resulting slope produced by this fit is the In-slope of the fluorescence vs. time and thus the In-slope of the viral growth vs. time. Equations are shown below.

FI(t) = Foea'-';where F1 is measured fluorescence intensity, t is time, Fo is the initial fluorescence

intensity at time = to, and a is the In-slope.

Take natural logarithm of both sides: 1 ] = ln(Fo) + a(t-to) In[FI(t)] = ln[Foea-(

) The right hand side is now a linear equation with a In-slope of a.

In view of the many possible embodiments to which the principles of the disclosure may be applied, it should be recognized that the illustrated embodiments are only examples of the invention and should not be taken as limiting the scope of the invention. Rather, the scope of the invention is defined by the following claims. We therefore claim as our invention all that comes within the scope and spirit of these claims. Where any or all of the terms "comprise", "comprises", "comprised" or "comprising" are used in this specification (including the claims) they are to be interpreted as specifying the presence of the stated features, integers, steps or components, but not precluding the presence of one or more other features, integers, steps or components. A reference herein to a patent document or any other matter identified as prior art, is not to be taken as an admission that the document or other matter was known or that the information it contains was part of the common general knowledge as at the priority date of any of the claims.

Sequence_Listing.txt SEQUENCE LISTING <110> SALK INSTITUTE FOR BIOLOGICAL STUDIES <120> EXOGENOUS GENE EXPRESSION IN THERAPEUTIC ADENOVIRUS FOR MINIMAL IMPACT ON VIRAL KINETICS

<130> 7158-96335-02 <150> US 62/298,653 <151> 2016-02-23

<160> 23 <170> PatentIn version 3.5

<210> 1 <211> 36791 <212> DNA <213> Artificial Sequence <220> <223> Synthetic adenovirus genome YPet-P2A-E1A <400> 1 catcatcaat aatatacctt attttggatt gaagccaata tgataatgag ggggtggagt 60 ttgtgacgtg gcgcggggcg tgggaacggg gcgggtgacg tagtagtgtg gcggaagtgt 120

gatgttgcaa gtgtggcgga acacatgtaa gcgacggatg tggcaaaagt gacgtttttg 180

gtgtgcgccg gtgtacacag gaagtgacaa ttttcgcgcg gttttaggcg gatgttgtag 240

taaatttggg cgtaaccgag taagatttgg ccattttcgc gggaaaactg aataagagga 300

agtgaaatct gaataatttt gtgttactca tagcgcgtaa tatttgtcta gggccgcggg 360 gactttgacc gtttacgtgg agactcgccc aggtgttttt ctcaggtgtt ttccgcgttc 420

cgggtcaaag ttggcgtttt attattatag tcagctgacg tgtagtgtat ttatacccgg 480

tgagttcctc aagaggccac tcttgagtgc cagcgagtag agttttctcc tccgagccgc 540 tccgacaccg ggactgaaaa tggtgagcaa aggcgaagag ctgttcaccg gcgtggtgcc 600

catcctggtg gagctggacg gcgacgtgaa cggccacaag ttcagcgtga gcggcgaggg 660 cgagggcgac gccacctacg gcaagctgac cctgaagctg ctgtgcacca ccggcaagct 720 gcccgtgccc tggcccaccc tggtgaccac cctgggctac ggcgtgcagt gcttcgcccg 780

gtaccccgac cacatgaagc agcacgactt cttcaagagc gccatgcccg agggctacgt 840 gcaggagcgg accatcttct tcaaggacga cggcaactac aagacccggg ccgaggtgaa 900 gttcgagggc gacaccctgg tgaaccggat cgagctgaag ggcatcgact tcaaggagga 960

cggcaacatc ctgggccaca agctggagta caactacaac agccacaacg tgtacatcac 1020 cgccgacaag cagaagaacg gcatcaaggc caacttcaag atccggcaca acatcgagga 1080

cggcggcgtg cagctggccg accactacca gcagaacacc cccatcggcg acggccccgt 1140 gctgctgccc gacaaccact acctgagcta ccagagcgcc ctgttcaagg accccaacga 1200 gaagcgggac cacatggtgc tgctggagtt cctgaccgcc gccggcatca ccgagggcat 1260

gaacgagctc tataagggaa gcggagctac taacttcagc ctgctgaagc aggctggtga 1320 Page 1

Sequence_Listing.txt cgtcgaggag aatcctggcc caatgagaca tattatctgc cacggaggtg ttattaccga 1380

agaaatggcc gccagtcttt tggaccagct gatcgaagag gtactggctg ataatcttcc 1440 acctcctagc cattttgaac cacctaccct tcacgaactg tatgatttag acgtgacggc 1500

ccccgaagat cccaacgagg aggcggtttc gcagattttt cccgactctg taatgttggc 1560 ggtgcaggaa gggattgact tactcacttt tccgccggcg cccggttctc cggagccgcc 1620 tcacctttcc cggcagcccg agcagccgga gcagagagcc ttgggtccgg tttctatgcc 1680

aaaccttgta ccggaggtga tcgatcttac ctgccacgag gctggctttc cacccagtga 1740 cgacgaggat gaagagggtg aggagtttgt gttagattat gtggagcacc ccgggcacgg 1800 ttgcaggtct tgtcattatc accggaggaa tacgggggac ccagatatta tgtgttcgct 1860

ttgctatatg aggacctgtg gcatgtttgt ctacagtaag tgaaaattat gggcagtggg 1920 tgatagagtg gtgggtttgg tgtggtaatt ttttttttaa tttttacagt tttgtggttt 1980 aaagaatttt gtattgtgat ttttttaaaa ggtcctgtgt ctgaacctga gcctgagccc 2040

gagccagaac cggagcctgc aagacctacc cgccgtccta aaatggcgcc tgctatcctg 2100 agacgcccga catcacctgt gtctagagaa tgcaatagta gtacggatag ctgtgactcc 2160

ggtccttcta acacacctcc tgagatacac ccggtggtcc cgctgtgccc cattaaacca 2220

gttgccgtga gagttggtgg gcgtcgccag gctgtggaat gtatcgagga cttgcttaac 2280

gagcctgggc aacctttgga cttgagctgt aaacgcccca ggccataagg tgtaaacctg 2340

tgattgcgtg tgtggttaac gcctttgttt gctgaatgag ttgatgtaag tttaataaag 2400 ggtgagataa tgtttaactt gcatggcgtg ttaaatgggg cggggcttaa agggtatata 2460

atgcgccgtg ggctaatctt ggttacatct gacctcatgg aggcttggga gtgtttggaa 2520

gatttttctg ctgtgcgtaa cttgctggaa cagagctcta acagtacctc ttggttttgg 2580 aggtttctgt ggggctcatc ccaggcaaag ttagtctgca gaattaagga ggattacaag 2640

tgggaatttg aagagctttt gaaatcctgt ggtgagctgt ttgattcttt gaatctgggt 2700 caccaggcgc ttttccaaga gaaggtcatc aagactttgg atttttccac accggggcgc 2760 gctgcggctg ctgttgcttt tttgagtttt ataaaggata aatggagcga agaaacccat 2820

ctgagcgggg ggtacctgct ggattttctg gccatgcatc tgtggagagc ggttgtgaga 2880 cacaagaatc gcctgctact gttgtcttcc gtccgcccgg cgataatacc gacggaggag 2940 cagcagcagc agcaggagga agccaggcgg cggcggcagg agcagagccc atggaacccg 3000

agagccggcc tggaccctcg ggaatgaatg ttgtacaggt ggctgaactg tatccagaac 3060 tgagacgcat tttgacaatt acagaggatg ggcaggggct aaagggggta aagagggagc 3120

ggggggcttg tgaggctaca gaggaggcta ggaatctagc ttttagctta atgaccagac 3180 accgtcctga gtgtattact tttcaacaga tcaaggataa ttgcgctaat gagcttgatc 3240 tgctggcgca gaagtattcc atagagcagc tgaccactta ctggctgcag ccaggggatg 3300

attttgagga ggctattagg gtatatgcaa aggtggcact taggccagat tgcaagtaca 3360 Page 2

Sequence_Listing.txt agatcagcaa acttgtaaat atcaggaatt gttgctacat ttctgggaac ggggccgagg 3420

tggagataga tacggaggat agggtggcct ttagatgtag catgataaat atgtggccgg 3480 gggtgcttgg catggacggg gtggttatta tgaatgtaag gtttactggc cccaatttta 3540

gcggtacggt tttcctggcc aataccaacc ttatcctaca cggtgtaagc ttctatgggt 3600 ttaacaatac ctgtgtggaa gcctggaccg atgtaagggt tcggggctgt gccttttact 3660 gctgctggaa gggggtggtg tgtcgcccca aaagcagggc ttcaattaag aaatgcctct 3720

ttgaaaggtg taccttgggt atcctgtctg agggtaactc cagggtgcgc cacaatgtgg 3780 cctccgactg tggttgcttc atgctagtga aaagcgtggc tgtgattaag cataacatgg 3840 tatgtggcaa ctgcgaggac agggcctctc agatgctgac ctgctcggac ggcaactgtc 3900

acctgctgaa gaccattcac gtagccagcc actctcgcaa ggcctggcca gtgtttgagc 3960 ataacatact gacccgctgt tccttgcatt tgggtaacag gaggggggtg ttcctacctt 4020 accaatgcaa tttgagtcac actaagatat tgcttgagcc cgagagcatg tccaaggtga 4080

acctgaacgg ggtgtttgac atgaccatga agatctggaa ggtgctgagg tacgatgaga 4140 cccgcaccag gtgcagaccc tgcgagtgtg gcggtaaaca tattaggaac cagcctgtga 4200

tgctggatgt gaccgaggag ctgaggcccg atcacttggt gctggcctgc acccgcgctg 4260

agtttggctc tagcgatgaa gatacagatt gaggtactga aatgtgtggg cgtggcttaa 4320

gggtgggaaa gaatatataa ggtgggggtc ttatgtagtt ttgtatctgt tttgcagcag 4380

ccgccgccgc ccaacttttc tatacaaagt tgtaatgagc accaactcgt ttgatggaag 4440 cattgtgagc tcatatttga caacgcgcat gcccccatgg gccggggtgc gtcagaatgt 4500

gatgggctcc agcattgatg gtcgccccgt cctgcccgca aactctacta ccttgaccta 4560

cgagaccgtg tctggaacgc cgttggagac tgcagcctcc gccgccgctt cagccgctgc 4620 agccaccgcc cgcgggattg tgactgactt tgctttcctg agcccgcttg caagcagtgc 4680

agcttcccgt tcatccgccc gcgatgacaa gttgacggct cttttggcac aattggattc 4740 tttgacccgg gaacttaatg tcgtttctca gcagctgttg gatctgcgcc agcaggtttc 4800 tgccctgaag gcttcctccc ctcccaatgc ggtttaaaac ataaataaaa aaccagactc 4860

tgtttggatt tggatcaagc ataagtgtct tgctgtcttt atttaggggt tttgcgcgcg 4920 cggtaggccc gggaccagcg gtctcggtcg ttgagggtcc tgtgtatttt ttccaggacg 4980 tggtaaaggt gactctggat gttcagatac atgggcataa gcccgtctct ggggtggagg 5040

tagcaccact gcagagcttc atgctgcggg gtggtgttgt agatgatcca gtcgtagcag 5100 gagcgctggg cgtggtgcct aaaaatgtct ttcagtagca agctgattgc caggggcagg 5160

cccttggtgt aagtgtttac aaagcggtta agctgggatg ggtgcatacg tggggatatg 5220 agatgcatct tggactgtat ttttaggttg gctatgttcc cagccatatc cctccgggga 5280 ttcatgttgt gcagaaccac cagcacagtg tatccggtgc acttgggaaa tttgtcatgt 5340

agcttagaag gaaatgcgtg gaagaacttg gagacgccct tgtgacctcc aagattttcc 5400 Page 3

Sequence_Listing.txt atgcattcgt ccataatgat ggcaatgggc ccacgggcgg cggcctgggc gaagatattt 5460

ctgggatcac taacgtcata gttgtgttcc aggatgagat cgtcataggc catttttaca 5520 aagcgcgggc ggagggtgcc agactgcggt ataatggttc catccggccc aggggcgtag 5580

ttaccctcac agatttgcat ttcccacgct ttgagttcag atggggggat catgtctacc 5640 tgcggggcga tgaagaaaac ggtttccggg gtaggggaga tcagctggga agaaagcagg 5700 ttcctgagca gctgcgactt accgcagccg gtgggcccgt aaatcacacc tattaccggg 5760

tgcaactggt agttaagaga gctgcagctg ccgtcatccc tgagcagggg ggccacttcg 5820 ttaagcatgt ccctgactcg catgttttcc ctgaccaaat ccgccagaag gcgctcgccg 5880 cccagcgata gcagttcttg caaggaagca aagtttttca acggtttgag accgtccgcc 5940

gtaggcatgc ttttgagcgt ttgaccaagc agttccaggc ggtcccacag ctcggtcacc 6000 tgctctacgg catctcgatc cagcatatct cctcgtttcg cgggttgggg cggctttcgc 6060 tgtacggcag tagtcggtgc tcgtccagac gggccagggt catgtctttc cacgggcgca 6120

gggtcctcgt cagcgtagtc tgggtcacgg tgaaggggtg cgctccgggc tgcgcgctgg 6180 ccagggtgcg cttgaggctg gtcctgctgg tgctgaagcg ctgccggtct tcgccctgcg 6240

cgtcggccag gtagcatttg accatggtgt catagtccag cccctccgcg gcgtggccct 6300

tggcgcgcag cttgcccttg gaggaggcgc cgcacgaggg gcagtgcaga cttttgaggg 6360

cgtagagctt gggcgcgaga aataccgatt ccggggagta ggcatccgcg ccgcaggccc 6420

cgcagacggt ctcgcattcc acgagccagg tgagctctgg ccgttcgggg tcaaaaacca 6480 ggtttccccc atgctttttg atgcgtttct tacctctggt ttccatgagc cggtgtccac 6540

gctcggtgac gaaaaggctg tccgtgtccc cgtatacaga cttgagaggc ctgtcctcga 6600

gcggtgttcc gcggtcctcc tcgtatagaa actcggacca ctctgagaca aaggctcgcg 6660 tccaggccag cacgaaggag gctaagtggg aggggtagcg gtcgttgtcc actagggggt 6720

ccactcgctc cagggtgtga agacacatgt cgccctcttc ggcatcaagg aaggtgattg 6780 gtttgtaggt gtaggccacg tgaccgggtg ttcctgaagg ggggctataa aagggggtgg 6840 gggcgcgttc gtcctcactc tcttccgcat cgctgtctgc gagggccagc tgttggggtg 6900

agtactccct ctgaaaagcg ggcatgactt ctgcgctaag attgtcagtt tccaaaaacg 6960 aggaggattt gatattcacc tggcccgcgg tgatgccttt gagggtggcc gcatccatct 7020 ggtcagaaaa gacaatcttt ttgttgtcaa gcttggtggc aaacgacccg tagagggcgt 7080

tggacagcaa cttggcgatg gagcgcaggg tttggttttt gtcgcgatcg gcgcgctcct 7140 tggccgcgat gtttagctgc acgtattcgc gcgcaacgca ccgccattcg ggaaagacgg 7200

tggtgcgctc gtcgggcacc aggtgcacgc gccaaccgcg gttgtgcagg gtgacaaggt 7260 caacgctggt ggctacctct ccgcgtaggc gctcgttggt ccagcagagg cggccgccct 7320 tgcgcgagca gaatggcggt agggggtcta gctgcgtctc gtccgggggg tctgcgtcca 7380

cggtaaagac cccgggcagc aggcgcgcgt cgaagtagtc tatcttgcat ccttgcaagt 7440 Page 4

Sequence_Listing.txt ctagcgcctg ctgccatgcg cgggcggcaa gcgcgcgctc gtatgggttg agtgggggac 7500

cccatggcat ggggtgggtg agcgcggagg cgtacatgcc gcaaatgtcg taaacgtaga 7560 ggggctctct gagtattcca agatatgtag ggtagcatct tccaccgcgg atgctggcgc 7620

gcacgtaatc gtatagttcg tgcgagggag cgaggaggtc gggaccgagg ttgctacggg 7680 cgggctgctc tgctcggaag actatctgcc tgaagatggc atgtgagttg gatgatatgg 7740 ttggacgctg gaagacgttg aagctggcgt ctgtgagacc taccgcgtca cgcacgaagg 7800

aggcgtagga gtcgcgcagc ttgttgacca gctcggcggt gacctgcacg tctagggcgc 7860 agtagtccag ggtttccttg atgatgtcat acttatcctg tccctttttt ttccacagct 7920 cgcggttgag gacaaactct tcgcggtctt tccagtactc ttggatcgga aacccgtcgg 7980

cctccgaacg gtaagagcct agcatgtaga actggttgac ggcctggtag gcgcagcatc 8040 ccttttctac gggtagcgcg tatgcctgcg cggccttccg gagcgaggtg tgggtgagcg 8100 caaaggtgtc cctgaccatg actttgaggt actggtattt gaagtcagtg tcgtcgcatc 8160

cgccctgctc ccagagcaaa aagtccgtgc gctttttgga acgcggattt ggcagggcga 8220 aggtgacatc gttgaagagt atctttcccg cgcgaggcat aaagttgcgt gtgatgcgga 8280

agggtcccgg cacctcggaa cggttgttaa ttacctgggc ggcgagcacg atctcgtcaa 8340

agccgttgat gttgtggccc acaatgtaaa gttccaagaa gcgcgggatg cccttgatgg 8400

aaggcaattt tttaagttcc tcgtaggtga gctcttcagg ggagctgagc ccgtgctctg 8460

aaagggccca gtctgcaaga tgagggttgg aagcgacgaa tgagctccac aggtcacggg 8520 ccattagcat ttgcaggtgg tcgcgaaagg tcctaaactg gcgacctatg gccatttttt 8580

ctggggtgat gcagtagaag gtaagcgggt cttgttccca gcggtcccat ccaaggttcg 8640

cggctaggtc tcgcgcggca gtcactagag gctcatctcc gccgaacttc atgaccagca 8700 tgaagggcac gagctgcttc ccaaaggccc ccatccaagt ataggtctct acatcgtagg 8760

tgacaaagag acgctcggtg cgaggatgcg agccgatcgg gaagaactgg atctcccgcc 8820 accaattgga ggagtggcta ttgatgtggt gaaagtagaa gtccctgcga cgggccgaac 8880 actcgtgctg gcttttgtaa aaacgtgcgc agtactggca gcggtgcacg ggctgtacat 8940

cctgcacgag gttgacctga cgaccgcgca caaggaagca gagtgggaat ttgagcccct 9000 cgcctggcgg gtttggctgg tggtcttcta cttcggctgc ttgtccttga ccgtctggct 9060 gctcgagggg agttacggtg gatcggacca ccacgccgcg cgagcccaaa gtccagatgt 9120

ccgcgcgcgg cggtcggagc ttgatgacaa catcgcgcag atgggagctg tccatggtct 9180 ggagctcccg cggcgtcagg tcaggcggga gctcctgcag gtttacctcg catagacggg 9240

tcagggcgcg ggctagatcc aggtgatacc taatttccag gggctggttg gtggcggcgt 9300 cgatggcttg caagaggccg catccccgcg gcgcgactac ggtaccgcgc ggcgggcggt 9360 gggccgcggg ggtgtccttg gatgatgcat ctaaaagcgg tgacgcgggc gagcccccgg 9420

aggtaggggg ggctccggac ccgccgggag agggggcagg ggcacgtcgg cgccgcgcgc 9480 Page 5

Sequence_Listing.txt gggcaggagc tggtgctgcg cgcgtaggtt gctggcgaac gcgacgacgc ggcggttgat 9540

ctcctgaatc tggcgcctct gcgtgaagac gacgggcccg gtgagcttga gcctgaaaga 9600 gagttcgaca gaatcaattt cggtgtcgtt gacggcggcc tggcgcaaaa tctcctgcac 9660

gtctcctgag ttgtcttgat aggcgatctc ggccatgaac tgctcgatct cttcctcctg 9720 gagatctccg cgtccggctc gctccacggt ggcggcgagg tcgttggaaa tgcgggccat 9780 gagctgcgag aaggcgttga ggcctccctc gttccagacg cggctgtaga ccacgccccc 9840

ttcggcatcg cgggcgcgca tgaccacctg cgcgagattg agctccacgt gccgggcgaa 9900 gacggcgtag tttcgcaggc gctgaaagag gtagttgagg gtggtggcgg tgtgttctgc 9960 cacgaagaag tacataaccc agcgtcgcaa cgtggattcg ttgatatccc ccaaggcctc 10020

aaggcgctcc atggcctcgt agaagtccac ggcgaagttg aaaaactggg agttgcgcgc 10080 cgacacggtt aactcctcct ccagaagacg gatgagctcg gcgacagtgt cgcgcacctc 10140 gcgctcaaag gctacagggg cctcttcttc ttcttcaatc tcctcttcca taagggcctc 10200

cccttcttct tcttctggcg gcggtggggg aggggggaca cggcggcgac gacggcgcac 10260 cgggaggcgg tcgacaaagc gctcgatcat ctccccgcgg cgacggcgca tggtctcggt 10320

gacggcgcgg ccgttctcgc gggggcgcag ttggaagacg ccgcccgtca tgtcccggtt 10380

atgggttggc ggggggctgc catgcggcag ggatacggcg ctaacgatgc atctcaacaa 10440

ttgttgtgta ggtactccgc cgccgaggga cctgagcgag tccgcatcga ccggatcgga 10500

aaacctctcg agaaaggcgt ctaaccagtc acagtcgcaa ggtaggctga gcaccgtggc 10560 gggcggcagc gggcggcggt cggggttgtt tctggcggag gtgctgctga tgatgtaatt 10620

aaagtaggcg gtcttgagac ggcggatggt cgacagaagc accatgtcct tgggtccggc 10680

ctgctgaatg cgcaggcggt cggccatgcc ccaggcttcg ttttgacatc ggcgcaggtc 10740 tttgtagtag tcttgcatga gcctttctac cggcacttct tcttctcctt cctcttgtcc 10800

tgcatctctt gcatctatcg ctgcggcggc ggcggagttt ggccgtaggt ggcgccctct 10860 tcctcccatg cgtgtgaccc cgaagcccct catcggctga agcagggcta ggtcggcgac 10920 aacgcgctcg gctaatatgg cctgctgcac ctgcgtgagg gtagactgga agtcatccat 10980

gtccacaaag cggtggtatg cgcccgtgtt gatggtgtaa gtgcagttgg ccataacgga 11040 ccagttaacg gtctggtgac ccggctgcga gagctcggtg tacctgagac gcgagtaagc 11100 cctcgagtca aatacgtagt cgttgcaagt ccgcaccagg tactggtatc ccaccaaaaa 11160

gtgcggcggc ggctggcggt agaggggcca gcgtagggtg gccggggctc cgggggcgag 11220 atcttccaac ataaggcgat gatatccgta gatgtacctg gacatccagg tgatgccggc 11280

ggcggtggtg gaggcgcgcg gaaagtcgcg gacgcggttc cagatgttgc gcagcggcaa 11340 aaagtgctcc atggtcggga cgctctggcc ggtcaggcgc gcgcaatcgt tgacgctcta 11400 gaccgtgcaa aaggagagcc tgtaagcggg cactcttccg tggtctggtg gataaattcg 11460

caagggtatc atggcggacg accggggttc gagccccgta tccggccgtc cgccgtgatc 11520 Page 6

Sequence_Listing.txt catgcggtta ccgcccgcgt gtcgaaccca ggtgtgcgac gtcagacaac gggggagtgc 11580

tccttttggc ttccttccag gcgcggcggc tgctgcgcta gcttttttgg ccactggccg 11640 cgcgcagcgt aagcggttag gctggaaagc gaaagcatta agtggctcgc tccctgtagc 11700

cggagggtta ttttccaagg gttgagtcgc gggacccccg gttcgagtct cggaccggcc 11760 ggactgcggc gaacgggggt ttgcctcccc gtcatgcaag accccgcttg caaattcctc 11820 cggaaacagg gacgagcccc ttttttgctt ttcccagatg catccggtgc tgcggcagat 11880

gcgcccccct cctcagcagc ggcaagagca agagcagcgg cagacatgca gggcaccctc 11940 ccctcctcct accgcgtcag gaggggcgac atccgcggtt gacgcggcag cagatggtga 12000 ttacgaaccc ccgcggcgcc gggcccggca ctacctggac ttggaggagg gcgagggcct 12060

ggcgcggcta ggagcgccct ctcctgagcg gtacccaagg gtgcagctga agcgtgatac 12120 gcgtgaggcg tacgtgccgc ggcagaacct gtttcgcgac cgcgagggag aggagcccga 12180 ggagatgcgg gatcgaaagt tccacgcagg gcgcgagctg cggcatggcc tgaatcgcga 12240

gcggttgctg cgcgaggagg actttgagcc cgacgcgcga accgggatta gtcccgcgcg 12300 cgcacacgtg gcggccgccg acctggtaac cgcatacgag cagacggtga accaggagat 12360

taactttcaa aaaagcttta acaaccacgt gcgtacgctt gtggcgcgcg aggaggtggc 12420

tataggactg atgcatctgt gggactttgt aagcgcgctg gagcaaaacc caaatagcaa 12480

gccgctcatg gcgcagctgt tccttatagt gcagcacagc agggacaacg aggcattcag 12540

ggatgcgctg ctaaacatag tagagcccga gggccgctgg ctgctcgatt tgataaacat 12600 cctgcagagc atagtggtgc aggagcgcag cttgagcctg gctgacaagg tggccgccat 12660

caactattcc atgcttagcc tgggcaagtt ttacgcccgc aagatatacc atacccctta 12720

cgttcccata gacaaggagg taaagatcga ggggttctac atgcgcatgg cgctgaaggt 12780 gcttaccttg agcgacgacc tgggcgttta tcgcaacgag cgcatccaca aggccgtgag 12840

cgtgagccgg cggcgcgagc tcagcgaccg cgagctgatg cacagcctgc aaagggccct 12900 ggctggcacg ggcagcggcg atagagaggc cgagtcctac tttgacgcgg gcgctgacct 12960 gcgctgggcc ccaagccgac gcgccctgga ggcagctggg gccggacctg ggctggcggt 13020

ggcacccgcg cgcgctggca acgtcggcgg cgtggaggaa tatgacgagg acgatgagta 13080 cgagccagag gacggcgagt actaagcggt gatgtttctg atcagatgat gcaagacgca 13140 acggacccgg cggtgcgggc ggcgctgcag agccagccgt ccggccttaa ctccacggac 13200

gactggcgcc aggtcatgga ccgcatcatg tcgctgactg cgcgcaatcc tgacgcgttc 13260 cggcagcagc cgcaggccaa ccggctctcc gcaattctgg aagcggtggt cccggcgcgc 13320

gcaaacccca cgcacgagaa ggtgctggcg atcgtaaacg cgctggccga aaacagggcc 13380 atccggcccg acgaggccgg cctggtctac gacgcgctgc ttcagcgcgt ggctcgttac 13440 aacagcggca acgtgcagac caacctggac cggctggtgg gggatgtgcg cgaggccgtg 13500

gcgcagcgtg agcgcgcgca gcagcagggc aacctgggct ccatggttgc actaaacgcc 13560 Page 7

Sequence_Listing.txt ttcctgagta cacagcccgc caacgtgccg cggggacagg aggactacac caactttgtg 13620

agcgcactgc ggctaatggt gactgagaca ccgcaaagtg aggtgtacca gtctgggcca 13680 gactattttt tccagaccag tagacaaggc ctgcagaccg taaacctgag ccaggctttc 13740

aaaaacttgc aggggctgtg gggggtgcgg gctcccacag gcgaccgcgc gaccgtgtct 13800 agcttgctga cgcccaactc gcgcctgttg ctgctgctaa tagcgccctt cacggacagt 13860 ggcagcgtgt cccgggacac atacctaggt cacttgctga cactgtaccg cgaggccata 13920

ggtcaggcgc atgtggacga gcatactttc caggagatta caagtgtcag ccgcgcgctg 13980 gggcaggagg acacgggcag cctggaggca accctaaact acctgctgac caaccggcgg 14040 cagaagatcc cctcgttgca cagtttaaac agcgaggagg agcgcatttt gcgctacgtg 14100

cagcagagcg tgagccttaa cctgatgcgc gacggggtaa cgcccagcgt ggcgctggac 14160 atgaccgcgc gcaacatgga accgggcatg tatgcctcaa accggccgtt tatcaaccgc 14220 ctaatggact acttgcatcg cgcggccgcc gtgaaccccg agtatttcac caatgccatc 14280

ttgaacccgc actggctacc gccccctggt ttctacaccg ggggattcga ggtgcccgag 14340 ggtaacgatg gattcctctg ggacgacata gacgacagcg tgttttcccc gcaaccgcag 14400

accctgctag agttgcaaca gcgcgagcag gcagaggcgg cgctgcgaaa ggaaagcttc 14460

cgcaggccaa gcagcttgtc cgatctaggc gctgcggccc cgcggtcaga tgctagtagc 14520

ccatttccaa gcttgatagg gtctcttacc agcactcgca ccacccgccc gcgcctgctg 14580

ggcgaggagg agtacctaaa caactcgctg ctgcagccgc agcgcgaaaa aaacctgcct 14640 ccggcatttc ccaacaacgg gatagagagc ctagtggaca agatgagtag atggaagacg 14700

tacgcgcagg agcacaggga cgtgccaggc ccgcgcccgc ccacccgtcg tcaaaggcac 14760

gaccgtcagc ggggtctggt gtgggaggac gatgactcgg cagacgacag cagcgtcctg 14820 gatttgggag ggagtggcaa cccgtttgcg caccttcgcc ccaggctggg gagaatgttt 14880

taaaaaaaaa aaagcatgat gcaaaataaa aaactcacca aggccatggc accgagcgtt 14940 ggttttcttg tattcccctt agtatgcggc gcgcggcgat gtatgaggaa ggtcctcctc 15000 cctcctacga gagtgtggtg agcgcggcgc cagtggcggc ggcgctgggt tctcccttcg 15060

atgctcccct ggacccgccg tttgtgcctc cgcggtacct gcggcctacc ggggggagaa 15120 acagcatccg ttactctgag ttggcacccc tattcgacac cacccgtgtg tacctggtgg 15180 acaacaagtc aacggatgtg gcatccctga actaccagaa cgaccacagc aactttctga 15240

ccacggtcat tcaaaacaat gactacagcc cgggggaggc aagcacacag accatcaatc 15300 ttgacgaccg gtcgcactgg ggcggcgacc tgaaaaccat cctgcatacc aacatgccaa 15360

atgtgaacga gttcatgttt accaataagt ttaaggcgcg ggtgatggtg tcgcgcttgc 15420 ctactaagga caatcaggtg gagctgaaat acgagtgggt ggagttcacg ctgcccgagg 15480 gcaactactc cgagaccatg accatagacc ttatgaacaa cgcgatcgtg gagcactact 15540

tgaaagtggg cagacagaac ggggttctgg aaagcgacat cggggtaaag tttgacaccc 15600 Page 8

Sequence_Listing.txt gcaacttcag actggggttt gaccccgtca ctggtcttgt catgcctggg gtatatacaa 15660

acgaagcctt ccatccagac atcattttgc tgccaggatg cggggtggac ttcacccaca 15720 gccgcctgag caacttgttg ggcatccgca agcggcaacc cttccaggag ggctttagga 15780

tcacctacga tgatctggag ggtggtaaca ttcccgcact gttggatgtg gacgcctacc 15840 aggcgagctt gaaagatgac accgaacagg gcgggggtgg cgcaggcggc agcaacagca 15900 gtggcagcgg cgcggaagag aactccaacg cggcagccgc ggcaatgcag ccggtggagg 15960

acatgaacga tcatgccatt cgcggcgaca cctttgccac acgggctgag gagaagcgcg 16020 ctgaggccga agcagcggcc gaagctgccg cccccgctgc gcaacccgag gtcgagaagc 16080 ctcagaagaa accggtgatc aaacccctga cagaggacag caagaaacgc agttacaacc 16140

taataagcaa tgacagcacc ttcacccagt accgcagctg gtaccttgca tacaactacg 16200 gcgaccctca gaccggaatc cgctcatgga ccctgctttg cactcctgac gtaacctgcg 16260 gctcggagca ggtctactgg tcgttgccag acatgatgca agaccccgtg accttccgct 16320

ccacgcgcca gatcagcaac tttccggtgg tgggcgccga gctgttgccc gtgcactcca 16380 agagcttcta caacgaccag gccgtctact cccaactcat ccgccagttt acctctctga 16440

cccacgtgtt caatcgcttt cccgagaacc agattttggc gcgcccgcca gcccccacca 16500

tcaccaccgt cagtgaaaac gttcctgctc tcacagatca cgggacgcta ccgctgcgca 16560

acagcatcgg aggagtccag cgagtgacca ttactgacgc cagacgccgc acctgcccct 16620

acgtttacaa ggccctgggc atagtctcgc cgcgcgtcct atcgagccgc actttttgag 16680 caagcatgtc catccttata tcgcccagca ataacacagg ctggggcctg cgcttcccaa 16740

gcaagatgtt tggcggggcc aagaagcgct ccgaccaaca cccagtgcgc gtgcgcgggc 16800

actaccgcgc gccctggggc gcgcacaaac gcggccgcac tgggcgcacc accgtcgatg 16860 acgccatcga cgcggtggtg gaggaggcgc gcaactacac gcccacgccg ccaccagtgt 16920

ccacagtgga cgcggccatt cagaccgtgg tgcgcggagc ccggcgctat gctaaaatga 16980 agagacggcg gaggcgcgta gcacgtcgcc accgccgccg acccggcact gccgcccaac 17040 gcgcggcggc ggccctgctt aaccgcgcac gtcgcaccgg ccgacgggcg gccatgcggg 17100

ccgctcgaag gctggccgcg ggtattgtca ctgtgccccc caggtccagg cgacgagcgg 17160 ccgccgcagc agccgcggcc attagtgcta tgactcaggg tcgcaggggc aacgtgtatt 17220 gggtgcgcga ctcggttagc ggcctgcgcg tgcccgtgcg cacccgcccc ccgcgcaact 17280

agattgcaag aaaaaactac ttagactcgt actgttgtat gtatccagcg gcggcggcgc 17340 gcaacgaagc tatgtccaag cgcaaaatca aagaagagat gctccaggtc atcgcgccgg 17400

agatctatgg ccccccgaag aaggaagagc aggattacaa gccccgaaag ctaaagcggg 17460 tcaaaaagaa aaagaaagat gatgatgatg aacttgacga cgaggtggaa ctgctgcacg 17520 ctaccgcgcc caggcgacgg gtacagtgga aaggtcgacg cgtaaaacgt gttttgcgac 17580

ccggcaccac cgtagtcttt acgcccggtg agcgctccac ccgcacctac aagcgcgtgt 17640 Page 9

Sequence_Listing.txt atgatgaggt gtacggcgac gaggacctgc ttgagcaggc caacgagcgc ctcggggagt 17700

ttgcctacgg aaagcggcat aaggacatgc tggcgttgcc gctggacgag ggcaacccaa 17760 cacctagcct aaagcccgta acactgcagc aggtgctgcc cgcgcttgca ccgtccgaag 17820

aaaagcgcgg cctaaagcgc gagtctggtg acttggcacc caccgtgcag ctgatggtac 17880 ccaagcgcca gcgactggaa gatgtcttgg aaaaaatgac cgtggaacct gggctggagc 17940 ccgaggtccg cgtgcggcca atcaagcagg tggcgccggg actgggcgtg cagaccgtgg 18000

acgttcagat acccactacc agtagcacca gtattgccac cgccacagag ggcatggaga 18060 cacaaacgtc cccggttgcc tcagcggtgg cggatgccgc ggtgcaggcg gtcgctgcgg 18120 ccgcgtccaa gacctctacg gaggtgcaaa cggacccgtg gatgtttcgc gtttcagccc 18180

cccggcgccc gcgcggttcg aggaagtacg gcgccgccag cgcgctactg cccgaatatg 18240 ccctacatcc ttccattgcg cctacccccg gctatcgtgg ctacacctac cgccccagaa 18300 gacgagcaac tacccgacgc cgaaccacca ctggaacccg ccgccgccgt cgccgtcgcc 18360

agcccgtgct ggccccgatt tccgtgcgca gggtggctcg cgaaggaggc aggaccctgg 18420 tgctgccaac agcgcgctac caccccagca tcgtttaaaa gccggtcttt gtggttcttg 18480

cagatatggc cctcacctgc cgcctccgtt tcccggtgcc gggattccga ggaagaatgc 18540

accgtaggag gggcatggcc ggccacggcc tgacgggcgg catgcgtcgt gcgcaccacc 18600

ggcggcggcg cgcgtcgcac cgtcgcatgc gcggcggtat cctgcccctc cttattccac 18660

tgatcgccgc ggcgattggc gccgtgcccg gaattgcatc cgtggccttg caggcgcaga 18720 gacactgatt aaaaacaagt tgcatgtgga aaaatcaaaa taaaaagtct ggactctcac 18780

gctcgcttgg tcctgtaact attttgtaga atggaagaca tcaactttgc gtctctggcc 18840

ccgcgacacg gctcgcgccc gttcatggga aactggcaag atatcggcac cagcaatatg 18900 agcggtggcg ccttcagctg gggctcgctg tggagcggca ttaaaaattt cggttccacc 18960

gttaagaact atggcagcaa ggcctggaac agcagcacag gccagatgct gagggataag 19020 ttgaaagagc aaaatttcca acaaaaggtg gtagatggcc tggcctctgg cattagcggg 19080 gtggtggacc tggccaacca ggcagtgcaa aataagatta acagtaagct tgatccccgc 19140

cctcccgtag aggagcctcc accggccgtg gagacagtgt ctccagaggg gcgtggcgaa 19200 aagcgtccgc gccccgacag ggaagaaact ctggtgacgc aaatagacga gcctccctcg 19260 tacgaggagg cactaaagca aggcctgccc accacccgtc ccatcgcgcc catggctacc 19320

ggagtgctgg gccagcacac acccgtaacg ctggacctgc ctccccccgc cgacacccag 19380 cagaaacctg tgctgccagg cccgaccgcc gttgttgtaa cccgtcctag ccgcgcgtcc 19440

ctgcgccgcg ccgccagcgg tccgcgatcg ttgcggcccg tagccagtgg caactggcaa 19500 agcacactga acagcatcgt gggtctgggg gtgcaatccc tgaagcgccg acgatgcttc 19560 tgaatagcta acgtgtcgta tgtgtgtcat gtatgcgtcc atgtcgccgc cagaggagct 19620

gctgagccgc cgcgcgcccg ctttccaaga tggctacccc ttcgatgatg ccgcagtggt 19680 Page 10

Sequence_Listing.txt cttacatgca catctcgggc caggacgcct cggagtacct gagccccggg ctggtgcagt 19740

ttgcccgcgc caccgagacg tacttcagcc tgaataacaa gtttagaaac cccacggtgg 19800 cgcctacgca cgacgtgacc acagaccggt cccagcgttt gacgctgcgg ttcatccctg 19860

tggaccgtga ggatactgcg tactcgtaca aggcgcggtt caccctagct gtgggtgata 19920 accgtgtgct ggacatggct tccacgtact ttgacatccg cggcgtgctg gacaggggcc 19980 ctacttttaa gccctactct ggcactgcct acaacgccct ggctcccaag ggtgccccaa 20040

atccttgcga atgggatgaa gctgctactg ctcttgaaat aaacctagaa gaagaggacg 20100 atgacaacga agacgaagta gacgagcaag ctgagcagca aaaaactcac gtatttgggc 20160 aggcgcctta ttctggtata aatattacaa aggagggtat tcaaataggt gtcgaaggtc 20220

aaacacctaa atatgccgat aaaacatttc aacctgaacc tcaaatagga gaatctcagt 20280 ggtacgaaac tgaaattaat catgcagctg ggagagtcct taaaaagact accccaatga 20340 aaccatgtta cggttcatat gcaaaaccca caaatgaaaa tggagggcaa ggcattcttg 20400

taaagcaaca aaatggaaag ctagaaagtc aagtggaaat gcaatttttc tcaactactg 20460 aggcgaccgc aggcaatggt gataacttga ctcctaaagt ggtattgtac agtgaagatg 20520

tagatataga aaccccagac actcatattt cttacatgcc cactattaag gaaggtaact 20580

cacgagaact aatgggccaa caatctatgc ccaacaggcc taattacatt gcttttaggg 20640

acaattttat tggtctaatg tattacaaca gcacgggtaa tatgggtgtt ctggcgggcc 20700

aagcatcgca gttgaatgct gttgtagatt tgcaagacag aaacacagag ctttcatacc 20760 agcttttgct tgattccatt ggtgatagaa ccaggtactt ttctatgtgg aatcaggctg 20820

ttgacagcta tgatccagat gttagaatta ttgaaaatca tggaactgaa gatgaacttc 20880

caaattactg ctttccactg ggaggtgtga ttaatacaga gactcttacc aaggtaaaac 20940 ctaaaacagg tcaggaaaat ggatgggaaa aagatgctac agaattttca gataaaaatg 21000

aaataagagt tggaaataat tttgccatgg aaatcaatct aaatgccaac ctgtggagaa 21060 atttcctgta ctccaacata gcgctgtatt tgcccgacaa gctaaagtac agtccttcca 21120 acgtaaaaat ttctgataac ccaaacacct acgactacat gaacaagcga gtggtggctc 21180

ccgggttagt ggactgctac attaaccttg gagcacgctg gtcccttgac tatatggaca 21240 acgtcaaccc atttaaccac caccgcaatg ctggcctgcg ctaccgctca atgttgctgg 21300 gcaatggtcg ctatgtgccc ttccacatcc aggtgcctca gaagttcttt gccattaaaa 21360

acctccttct cctgccgggc tcatacacct acgagtggaa cttcaggaag gatgttaaca 21420 tggttctgca gagctcccta ggaaatgacc taagggttga cggagccagc attaagtttg 21480

atagcatttg cctttacgcc accttcttcc ccatggccca caacaccgcc tccacgcttg 21540 aggccatgct tagaaacgac accaacgacc agtcctttaa cgactatctc tccgccgcca 21600 acatgctcta ccctataccc gccaacgcta ccaacgtgcc catatccatc ccctcccgca 21660

actgggcggc tttccgcggc tgggccttca cgcgccttaa gactaaggaa accccatcac 21720 Page 11

Sequence_Listing.txt tgggctcggg ctacgaccct tattacacct actctggctc tataccctac ctagatggaa 21780

ccttttacct caaccacacc tttaagaagg tggccattac ctttgactct tctgtcagct 21840 ggcctggcaa tgaccgcctg cttaccccca acgagtttga aattaagcgc tcagttgacg 21900

gggagggtta caacgttgcc cagtgtaaca tgaccaaaga ctggttcctg gtacaaatgc 21960 tagctaacta caacattggc taccagggct tctatatccc agagagctac aaggaccgca 22020 tgtactcctt ctttagaaac ttccagccca tgagccgtca ggtggtggat gatactaaat 22080

acaaggacta ccaacaggtg ggcatcctac accaacacaa caactctgga tttgttggct 22140 accttgcccc caccatgcgc gaaggacagg cctaccctgc taacttcccc tatccgctta 22200 taggcaagac cgcagttgac agcattaccc agaaaaagtt tctttgcgat cgcacccttt 22260

ggcgcatccc attctccagt aactttatgt ccatgggcgc actcacagac ctgggccaaa 22320 accttctcta cgccaactcc gcccacgcgc tagacatgac ttttgaggtg gatcccatgg 22380 acgagcccac ccttctttat gttttgtttg aagtctttga cgtggtccgt gtgcaccggc 22440

cgcaccgcgg cgtcatcgaa accgtgtacc tgcgcacgcc cttctcggcc ggcaacgcca 22500 caacataaag aagcaagcaa catcaacaac agctgccgcc atgggctcca gtgagcagga 22560

actgaaagcc attgtcaaag atcttggttg tgggccatat tttttgggca cctatgacaa 22620

gcgctttcca ggctttgttt ctccacacaa gctcgcctgc gccatagtca atacggccgg 22680

tcgcgagact gggggcgtac actggatggc ctttgcctgg aacccgcact caaaaacatg 22740

ctacctcttt gagccctttg gcttttctga ccagcgactc aagcaggttt accagtttga 22800 gtacgagtca ctcctgcgcc gtagcgccat tgcttcttcc cccgaccgct gtataacgct 22860

ggaaaagtcc acccaaagcg tacaggggcc caactcggcc gcctgtggac tattctgctg 22920

catgtttctc cacgcctttg ccaactggcc ccaaactccc atggatcaca accccaccat 22980 gaaccttatt accggggtac ccaactccat gctcaacagt ccccaggtac agcccaccct 23040

gcgtcgcaac caggaacagc tctacagctt cctggagcgc cactcgccct acttccgcag 23100 ccacagtgcg cagattagga gcgccacttc tttttgtcac ttgaaaaaca tgtaaaaata 23160 atgtactaga gacactttca ataaaggcaa atgcttttat ttgtacactc tcgggtgatt 23220

atttaccccc acccttgccg tctgcgccgt ttaaaaatca aaggggttct gccgcgcatc 23280 gctatgcgcc actggcaggg acacgttgcg atactggtgt ttagtgctcc acttaaactc 23340 aggcacaacc atccgcggca gctcggtgaa gttttcactc cacaggctgc gcaccatcac 23400

caacgcgttt agcaggtcgg gcgccgatat cttgaagtcg cagttggggc ctccgccctg 23460 cgcgcgcgag ttgcgataca cagggttgca gcactggaac actatcagcg ccgggtggtg 23520

cacgctggcc agcacgctct tgtcggagat cagatccgcg tccaggtcct ccgcgttgct 23580 cagggcgaac ggagtcaact ttggtagctg ccttcccaaa aagggcgcgt gcccaggctt 23640 tgagttgcac tcgcaccgta gtggcatcaa aaggtgaccg tgcccggtct gggcgttagg 23700

atacagcgcc tgcataaaag ccttgatctg cttaaaagcc acctgagcct ttgcgccttc 23760 Page 12

Sequence_Listing.txt agagaagaac atgccgcaag acttgccgga aaactgattg gccggacagg ccgcgtcgtg 23820

cacgcagcac cttgcgtcgg tgttggagat ctgcaccaca tttcggcccc accggttctt 23880 cacgatcttg gccttgctag actgctcctt cagcgcgcgc tgcccgtttt cgctcgtcac 23940

atccatttca atcacgtgct ccttatttat cataatgctt ccgtgtagac acttaagctc 24000 gccttcgatc tcagcgcagc ggtgcagcca caacgcgcag cccgtgggct cgtgatgctt 24060 gtaggtcacc tctgcaaacg actgcaggta cgcctgcagg aatcgcccca tcatcgtcac 24120

aaaggtcttg ttgctggtga aggtcagctg caacccgcgg tgctcctcgt tcagccaggt 24180 cttgcatacg gccgccagag cttccacttg gtcaggcagt agtttgaagt tcgcctttag 24240 atcgttatcc acgtggtact tgtccatcag cgcgcgcgca gcctccatgc ccttctccca 24300

cgcagacacg atcggcacac tcagcgggtt catcaccgta atttcacttt ccgcttcgct 24360 gggctcttcc tcttcctctt gcgtccgcat accacgcgcc actgggtcgt cttcattcag 24420 ccgccgcact gtgcgcttac ctcctttgcc atgcttgatt agcaccggtg ggttgctgaa 24480

acccaccatt tgtagcgcca catcttctct ttcttcctcg ctgtccacga ttacctctgg 24540 tgatggcggg cgctcgggct tgggagaagg gcgcttcttt ttcttcttgg gcgcaatggc 24600

caaatccgcc gccgaggtcg atggccgcgg gctgggtgtg cgcggcacca gcgcgtcttg 24660

tgatgagtct tcctcgtcct cggactcgat acgccgcctc atccgctttt ttgggggcgc 24720

ccggggaggc ggcggcgacg gggacgggga cgacacgtcc tccatggttg ggggacgtcg 24780

cgccgcaccg cgtccgcgct cgggggtggt ttcgcgctgc tcctcttccc gactggccat 24840 ttccttctcc tataggcaga aaaagatcat ggagtcagtc gagaagaagg acagcctaac 24900

cgccccctct gagttcgcca ccaccgcctc caccgatgcc gccaacgcgc ctaccacctt 24960

ccccgtcgag gcacccccgc ttgaggagga ggaagtgatt atcgagcagg acccaggttt 25020 tgtaagcgaa gacgacgagg accgctcagt accaacagag gataaaaagc aagaccagga 25080

caacgcagag gcaaacgagg aacaagtcgg gcggggggac gaaaggcatg gcgactacct 25140 agatgtggga gacgacgtgc tgttgaagca tctgcagcgc cagtgcgcca ttatctgcga 25200 cgcgttgcaa gagcgcagcg atgtgcccct cgccatagcg gatgtcagcc ttgcctacga 25260

acgccaccta ttctcaccgc gcgtaccccc caaacgccaa gaaaacggca catgcgagcc 25320 caacccgcgc ctcaacttct accccgtatt tgccgtgcca gaggtgcttg ccacctatca 25380 catctttttc caaaactgca agatacccct atcctgccgt gccaaccgca gccgagcgga 25440

caagcagctg gccttgcggc agggcgctgt catacctgat atcgcctcgc tcaacgaagt 25500 gccaaaaatc tttgagggtc ttggacgcga cgagaagcgc gcggcaaacg ctctgcaaca 25560

ggaaaacagc gaaaatgaaa gtcactctgg agtgttggtg gaactcgagg gtgacaacgc 25620 gcgcctagcc gtactaaaac gcagcatcga ggtcacccac tttgcctacc cggcacttaa 25680 cctacccccc aaggtcatga gcacagtcat gagtgagctg atcgtgcgcc gtgcgcagcc 25740

cctggagagg gatgcaaatt tgcaagaaca aacagaggag ggcctacccg cagttggcga 25800 Page 13

Sequence_Listing.txt cgagcagcta gcgcgctggc ttcaaacgcg cgagcctgcc gacttggagg agcgacgcaa 25860

actaatgatg gccgcagtgc tcgttaccgt ggagcttgag tgcatgcagc ggttctttgc 25920 tgacccggag atgcagcgca agctagagga aacattgcac tacacctttc gacagggcta 25980

cgtacgccag gcctgcaaga tctccaacgt ggagctctgc aacctggtct cctaccttgg 26040 aattttgcac gaaaaccgcc ttgggcaaaa cgtgcttcat tccacgctca agggcgaggc 26100 gcgccgcgac tacgtccgcg actgcgttta cttatttcta tgctacacct ggcagacggc 26160

catgggcgtt tggcagcagt gcttggagga gtgcaacctc aaggagctgc agaaactgct 26220 aaagcaaaac ttgaaggacc tatggacggc cttcaacgag cgctccgtgg ccgcgcacct 26280 ggcggacatc attttccccg aacgcctgct taaaaccctg caacagggtc tgccagactt 26340

caccagtcaa agcatgttgc agaactttag gaactttatc ctagagcgct caggaatctt 26400 gcccgccacc tgctgtgcac ttcctagcga ctttgtgccc attaagtacc gcgaatgccc 26460 tccgccgctt tggggccact gctaccttct gcagctagcc aactaccttg cctaccactc 26520

tgacataatg gaagacgtga gcggtgacgg tctactggag tgtcactgtc gctgcaacct 26580 atgcaccccg caccgctccc tggtttgcaa ttcgcagctg cttaacgaaa gtcaaattat 26640

cggtaccttt gagctgcagg gtccctcgcc tgacgaaaag tccgcggctc cggggttgaa 26700

actcactccg gggctgtgga cgtcggctta ccttcgcaaa tttgtacctg aggactacca 26760

cgcccacgag attaggttct acgaagacca atcccgcccg ccaaatgcgg agcttaccgc 26820

ctgcgtcatt acccagggcc acattcttgg ccaattgcaa gccatcaaca aagcccgcca 26880 agagtttctg ctacgaaagg gacggggggt ttacttggac ccccagtccg gcgaggagct 26940

caacccaatc cccccgccgc cgcagcccta tcagcagcag ccgcgggccc ttgcttccca 27000

ggatggcacc caaaaagaag ctgcagctgc cgccgccacc cacggacgag gaggaatact 27060 gggacagtca ggcagaggag gttttggacg aggaggagga ggacatgatg gaagactggg 27120

agagcctaga cgaggaagct tccgaggtcg aagaggtgtc agacgaaaca ccgtcaccct 27180 cggtcgcatt cccctcgccg gcgccccaga aatcggcaac cggttccagc atggctacaa 27240 cctccgctcc tcaggcgccg ccggcactgc ccgttcgccg acccaaccgt agatgggaca 27300

ccactggaac cagggccggt aagtccaagc agccgccgcc gttagcccaa gagcaacaac 27360 agcgccaagg ctaccgctca tggcgcgggc acaagaacgc catagttgct tgcttgcaag 27420 actgtggggg caacatctcc ttcgcccgcc gctttcttct ctaccatcac ggcgtggcct 27480

tcccccgtaa catcctgcat tactaccgtc atctctacag cccatactgc accggcggca 27540 gcggcagcgg cagcaacagc agcggccaca cagaagcaaa ggcgaccgga tagcaagact 27600

ctgacaaagc ccaagaaatc cacagcggcg gcagcagcag gaggaggagc gctgcgtctg 27660 gcgcccaacg aacccgtatc gacccgcgag cttagaaaca ggatttttcc cactctgtat 27720 gctatatttc aacagagcag gggccaagaa caagagctga aaataaaaaa caggtctctg 27780

cgatccctca cccgcagctg cctgtatcac aaaagcgaag atcagcttcg gcgcacgctg 27840 Page 14

Sequence_Listing.txt gaagacgcgg aggctctctt cagtaaatac tgcgcgctga ctcttaagga ctagtttcgc 27900

gccctttctc aaatttaagc gcgaaaacta cgtcatctcc agcggccaca cccggcgcca 27960 gcacctgtcg tcagcgccat ttcaactttg tatacaaaag ttgtgatgag caaggaaatt 28020

cccacgccct acatgtggag ttaccagcca caaatgggac ttgcggctgg agctgcccaa 28080 gactactcaa cccgaataaa ctacatgagc gcgggacccc acatgatatc ccgggtcaac 28140 ggaatacgcg cccaccgaaa ccgaattctc ctggaacagg cggctattac caccacacct 28200

cgtaataacc ttaatccccg tagttggccc gctgccctgg tgtaccagga aagtcccgct 28260 cccaccactg tggtacttcc cagagacgcc caggccgaag ttcagatgac taactcaggg 28320 gcgcagcttg cgggcggctt tcgtcacagg gtgcggtcgc ccgggcaggg tataactcac 28380

ctgacaatca gagggcgagg tattcagctc aacgacgagt cggtgagctc ctcgcttggt 28440 ctccgtccgg acgggacatt tcagatcggc ggcgccggcc gctcttcatt cacgcctcgt 28500 caggcaatcc taactctgca gacctcgtcc tctgagccgc gctctggagg cattggaact 28560

ctgcaattta ttgaggagtt tgtgccatcg gtctacttta accccttctc gggacctccc 28620 ggccactatc cggatcaatt tattcctaac tttgacgcgg taaaggactc ggcggacggc 28680

tacgactgaa tgttaagtgg agaggcagag caactgcgcc tgaaacacct ggtccactgt 28740

cgccgccaca agtgctttgc ccgcgactcc ggtgagtttt gctactttga attgcccgag 28800

gatcatatcg agggcccggc gcacggcgtc cggcttaccg cccagggaga gcttgcccgt 28860

agcctgattc gggagtttac ccagcgcccc ctgctagttg agcgggacag gggaccctgt 28920 gttctcactg tgatttgcaa ctgtcctaac cctggattac atcaagatct ttgttgccat 28980

ctctgtgctg agtataataa atacagaaat taaaatatac tggggctcct atcgccatcc 29040

tgtaaacgcc accgtcttca cccgcccaag caaaccaagg cgaaccttac ctggtacttt 29100 taacatctct ccctctgtga tttacaacag tttcaaccca gacggagtga gtctacgaga 29160

gaacctctcc gagctcagct actccatcag aaaaaacacc accctcctta cctgccggga 29220 acgtacgagt gcgtcaccgg ccgctgcacc acacctaccg cctgaccgta aaccagactt 29280 tttccggaca gacctcaata actctgttta ccagaacagg aggtgagctt agaaaaccct 29340

tagggtatta ggccaaaggc gcagctactg tggggtttat gaacaattca agcaactcta 29400 cgggctattc taattcaggt ttctctagaa tcggggttgg ggttattctc tgtcttgtga 29460 ttctctttat tcttatacta acgcttctct gcctaaggct cgccgcctgc tgtgtgcaca 29520

tttgcattta ttgtcagctt tttaaacgct ggggtcgcca cccaagatga ttaggtacat 29580 aatcctaggt ttactcaccc ttgcgtcagc ccacggtacc acccaaaagg tggattttaa 29640

ggagccagcc tgtaatgtta cattcgcagc tgaagctaat gagtgcacca ctcttataaa 29700 atgcaccaca gaacatgaaa agctgcttat tcgccacaaa aacaaaattg gcaagtatgc 29760 tgtttatgct atttggcagc caggtgacac tacagagtat aatgttacag ttttccaggg 29820

taaaagtcat aaaactttta tgtatacttt tccattttat gaaatgtgcg acattaccat 29880 Page 15

Sequence_Listing.txt gtacatgagc aaacagtata agttgtggcc cccacaaaat tgtgtggaaa acactggcac 29940

tttctgctgc actgctatgc taattacagt gctcgctttg gtctgtaccc tactctatat 30000 taaatacaaa agcagacgca gctttattga ggaaaagaaa atgccttaat ttactaagtt 30060

acaaagctaa tgtcaccact aactgcttta ctcgctgctt gcaaaacaaa ttcaaaaagt 30120 tagcattata attagaatag gatttaaacc ccccggtcat ttcctgctca ataccattcc 30180 cctgaacaat tgactctatg tgggatatgc tccagcgcta caaccttgaa gtcaggcttc 30240

ctggatgtca gcatctgact ttggccagca cctgtcccgc ggatttgttc cagtccaact 30300 acagcgaccc accctaacag agatgaccaa cacaaccaac gcggccgccg ctaccggact 30360 tacatctacc acaaatacac cccaagtttc tgcctttgtc aataactggg ataacttggg 30420

catgtggtgg ttctccatag cgcttatgtt tgtatgcctt attattatgt ggctcatctg 30480 ctgcctaaag cgcaaacgcg cccgaccacc catctatagt cccatcattg tgctacaccc 30540 aaacaatgat ggaatccata gattggacgg actgaaacac atgttctttt ctcttacagt 30600

atgattaaat gagacatgat tcctcgagtt tttatattac tgacccttgt tgcgcttttt 30660 tgtgcgtgct ccacattggc tgcggtttct cacatcgaag tagactgcat tccagccttc 30720

acagtctatt tgctttacgg atttgtcacc ctcacgctca tctgcagcct catcactgtg 30780

gtcatcgcct ttatccagtg cattgactgg gtctgtgtgc gctttgcata tctcagacac 30840

catccccagt acagggacag gactatagct gagcttctta gaattcttta attatgaaat 30900

ttactgtgac ttttctgctg attatttgca ccctatctgc gttttgttcc ccgacctcca 30960 agcctcaaag acatatatca tgcagattca ctcgtatatg gaatattcca agttgctaca 31020

atgaaaaaag cgatctttcc gaagcctggt tatatgcaat catctctgtt atggtgttct 31080

gcagtaccat cttagcccta gctatatatc cctaccttga cattggctgg aacgcaatag 31140 atgccatgaa ccacccaact ttccccgcgc ccgctatgct tccactgcaa caagttgttg 31200

ccggcggctt tgtcccagcc aatcagcctc gcccaccttc tcccaccccc actgaaatca 31260 gctactttaa tctaacagga ggagatgact gacaccctag atctagaaat ggacggaatt 31320 attacagagc agcgcctgct agaaagacgc agggcagcgg ccgagcaaca gcgcatgaat 31380

caagagctcc aagacatggt taacttgcac cagtgcaaaa ggggtatctt ttgtctggta 31440 aagcaggcca aagtcaccta cgacagtaat accaccggac accgccttag ctacaagttg 31500 ccaaccaagc gtcagaaatt ggtggtcatg gtgggagaaa agcccattac cataactcag 31560

cactcggtag aaaccgaagg ctgcattcac tcaccttgtc aaggacctga ggatctctgc 31620 acccttatta agaccctgtg cggtctcaaa gatcttattc cctttaacta ataaaaaaaa 31680

ataataaagc atcacttact taaaatcagt tagcaaattt ctgtccagtt tattcagcag 31740 cacctccttg ccctcctccc agctctggta ttgcagcttc ctcctggctg caaactttct 31800 ccacaatcta aatggaatgt cagtttcctc ctgttcctgt ccatccgcac ccactatctt 31860

catgttgttg cagatgaagc gcgcaagacc gtctgaagat accttcaacc ccgtgtatcc 31920 Page 16

Sequence_Listing.txt atatgacacg gaaaccggtc ctccaactgt gccttttctt actcctccct ttgtatcccc 31980

caatgggttt caagagagtc cccctggggt actctctttg cgcctatccg aacctctagt 32040 tacctccaat ggcatgcttg cgctcaaaat gggcaacggc ctctctctgg acgaggccgg 32100

caaccttacc tcccaaaatg taaccactgt gagcccacct ctcaaaaaaa ccaagtcaaa 32160 cataaacctg gaaatatctg cacccctcac agttacctca gaagccctaa ctgtggctgc 32220 cgccgcacct ctaatggtcg cgggcaacac actcaccatg caatcacagg ccccgctaac 32280

cgtgcacgac tccaaactta gcattgccac ccaaggaccc ctcacagtgt cagaaggaaa 32340 gctagccctg caaacatcag gccccctcac caccaccgat agcagtaccc ttactatcac 32400 tgcctcaccc cctctaacta ctgccactgg tagcttgggc attgacttga aagagcccat 32460

ttatacacaa aatggaaaac taggactaaa gtacggggct cctttgcatg taacagacga 32520 cctaaacact ttgaccgtag caactggtcc aggtgtgact attaataata cttccttgca 32580 aactaaagtt actggagcct tgggttttga ttcacaaggc aatatgcaac ttaatgtagc 32640

aggaggacta aggattgatt ctcaaaacag acgccttata cttgatgtta gttatccgtt 32700 tgatgctcaa aaccaactaa atctaagact aggacagggc cctcttttta taaactcagc 32760

ccacaacttg gatattaact acaacaaagg cctttacttg tttacagctt caaacaattc 32820

caaaaagctt gaggttaacc taagcactgc caaggggttg atgtttgacg ctacagccat 32880

agccattaat gcaggagatg ggcttgaatt tggttcacct aatgcaccaa acacaaatcc 32940

cctcaaaaca aaaattggcc atggcctaga atttgattca aacaaggcta tggttcctaa 33000 actaggaact ggccttagtt ttgacagcac aggtgccatt acagtaggaa acaaaaataa 33060

tgataagcta actttgtgga ccacaccagc tccatctcct aactgtagac taaatgcaga 33120

gaaagatgct aaactcactt tggtcttaac aaaatgtggc agtcaaatac ttgctacagt 33180 ttcagttttg gctgttaaag gcagtttggc tccaatatct ggaacagttc aaagtgctca 33240

tcttattata agatttgacg aaaatggagt gctactaaac aattccttcc tggacccaga 33300 atattggaac tttagaaatg gagatcttac tgaaggcaca gcctatacaa acgctgttgg 33360 atttatgcct aacctatcag cttatccaaa atctcacggt aaaactgcca aaagtaacat 33420

tgtcagtcaa gtttacttaa acggagacaa aactaaacct gtaacactaa ccattacact 33480 aaacggtaca caggaaacag gagacacaac tccaagtgca tactctatgt cattttcatg 33540 ggactggtct ggccacaact acattaatga aatatttgcc acatcctctt acactttttc 33600

atacattgcc caagaataaa gaatcgtttg tgttatgttt caacgtgttt atttttcaat 33660 tgcagaaaat ttcaagtcat ttttcattca gtagtatagc cccaccacca catagcttat 33720

acagatcacc gtacctcaac tttgtataat aaagttgtaa tcaaactcac agaaccctag 33780 tattcaacct gccacctccc tcccaacaca cagagtacac agtcctttct ccccggctgg 33840 ccttaaaaag catcatatca tgggtaacag acatattctt aggtgttata ttccacacgg 33900

tttcctgtcg agccaaacgc tcatcagtga tattaataaa ctccccgggc agctcactta 33960 Page 17

Sequence_Listing.txt agttcatgtc gctgtccagc tgctgagcca caggctgctg tccaacttgc ggttgcttaa 34020

cgggcggcga aggagaagtc cacgcctaca tgggggtaga gtcataatcg tgcatcagga 34080 tagggcggtg gtgctgcagc agcgcgcgaa taaactgctg ccgccgccgc tccgtcctgc 34140

aggaatacaa catggcagtg gtctcctcag cgatgattcg caccgcccgc agcataaggc 34200 gccttgtcct ccgggcacag cagcgcaccc tgatctcact taaatcagca cagtaactgc 34260 agcacagcac cacaatattg ttcaaaatcc cacagtgcaa ggcgctgtat ccaaagctca 34320

tggcggggac cacagaaccc acgtggccat cataccacaa gcgcaggtag attaagtggc 34380 gacccctcat aaacacgctg gacataaaca ttacctcttt tggcatgttg taattcacca 34440 cctcccggta ccatataaac ctctgattaa acatggcgcc atccaccacc atcctaaacc 34500

agctggccaa aacctgcccg ccggctatac actgcaggga accgggactg gaacaatgac 34560 agtggagagc ccaggactcg taaccatgga tcatcatgct cgtcatgata tcaatgttgg 34620 cacaacacag gcacacgtgc atacacttcc tcaggattac aagctcctcc cgcgttagaa 34680

ccatatccca gggaacaacc cattcctgaa tcagcgtaaa tcccacactg cagggaagac 34740 ctcgcacgta actcacgttg tgcattgtca aagtgttaca ttcgggcagc agcggatgat 34800

cctccagtat ggtagcgcgg gtttctgtct caaaaggagg tagacgatcc ctactgtacg 34860

gagtgcgccg agacaaccga gatcgtgttg gtcgtagtgt catgccaaat ggaacgccgg 34920

acgtagtcat atttcctgaa gcaaaaccag gtgcgggcgt gacaaacaga tctgcgtctc 34980

cggtctcgcc gcttagatcg ctctgtgtag tagttgtagt atatccactc tctcaaagca 35040 tccaggcgcc ccctggcttc gggttctatg taaactcctt catgcgccgc tgccctgata 35100

acatccacca ccgcagaata agccacaccc agccaaccta cacattcgtt ctgcgagtca 35160

cacacgggag gagcgggaag agctggaaga accatgtttt tttttttatt ccaaaagatt 35220 atccaaaacc tcaaaatgaa gatctattaa gtgaacgcgc tcccctccgg tggcgtggtc 35280

aaactctaca gccaaagaac agataatggc atttgtaaga tgttgcacaa tggcttccaa 35340 aaggcaaacg gccctcacgt ccaagtggac gtaaaggcta aacccttcag ggtgaatctc 35400 ctctataaac attccagcac cttcaaccat gcccaaataa ttctcatctc gccaccttct 35460

caatatatct ctaagcaaat cccgaatatt aagtccggcc attgtaaaaa tctgctccag 35520 agcgccctcc accttcagcc tcaagcagcg aatcatgatt gcaaaaattc aggttcctca 35580 cagacctgta taagattcaa aagcggaaca ttaacaaaaa taccgcgatc ccgtaggtcc 35640

cttcgcaggg ccagctgaac ataatcgtgc aggtctgcac ggaccagcgc ggccacttcc 35700 ccgccaggaa ccatgacaaa agaacccaca ctgattatga cacgcatact cggagctatg 35760

ctaaccagcg tagccccgat gtaagcttgt tgcatgggcg gcgatataaa atgcaaggtg 35820 ctgctcaaaa aatcaggcaa agcctcgcgc aaaaaagaaa gcacatcgta gtcatgctca 35880 tgcagataaa ggcaggtaag ctccggaacc accacagaaa aagacaccat ttttctctca 35940

aacatgtctg cgggtttctg cataaacaca aaataaaata acaaaaaaac atttaaacat 36000 Page 18

Sequence_Listing.txt tagaagcctg tcttacaaca ggaaaaacaa cccttataag cataagacgg actacggcca 36060

tgccggcgtg accgtaaaaa aactggtcac cgtgattaaa aagcaccacc gacagctcct 36120 cggtcatgtc cggagtcata atgtaagact cggtaaacac atcaggttga ttcacatcgg 36180

tcagtgctaa aaagcgaccg aaatagcccg ggggaataca tacccgcagg cgtagagaca 36240 acattacagc ccccatagga ggtataacaa aattaatagg agagaaaaac acataaacac 36300 ctgaaaaacc ctcctgccta ggcaaaatag caccctcccg ctccagaaca acatacagcg 36360

cttccacagc ggcagccata acagtcagcc ttaccagtaa aaaagaaaac ctattaaaaa 36420 aacaccactc gacacggcac cagctcaatc agtcacagtg taaaaaaggg ccaagtgcag 36480 agcgagtata tataggacta aaaaatgacg taacggttaa agtccacaaa aaacacccag 36540

aaaaccgcac gcgaacctac gcccagaaac gaaagccaaa aaacccacaa cttcctcaaa 36600 tcgtcacttc cgttttccca cgttacgtca cttcccattt taagaaaact acaattccca 36660 acacatacaa gttactccgc cctaaaacct acgtcacccg ccccgttccc acgccccgcg 36720

ccacgtcaca aactccaccc cctcattatc atattggctt caatccaaaa taaggtatat 36780 tattgatgat g 36791

<210> 2 <211> 36791 <212> DNA <213> Artificial Sequence

<220> <223> Synthetic adenovirus genome E1A-P2A-YPet

<400> 2 catcatcaat aatatacctt attttggatt gaagccaata tgataatgag ggggtggagt 60

ttgtgacgtg gcgcggggcg tgggaacggg gcgggtgacg tagtagtgtg gcggaagtgt 120 gatgttgcaa gtgtggcgga acacatgtaa gcgacggatg tggcaaaagt gacgtttttg 180

gtgtgcgccg gtgtacacag gaagtgacaa ttttcgcgcg gttttaggcg gatgttgtag 240 taaatttggg cgtaaccgag taagatttgg ccattttcgc gggaaaactg aataagagga 300 agtgaaatct gaataatttt gtgttactca tagcgcgtaa tatttgtcta gggccgcggg 360

gactttgacc gtttacgtgg agactcgccc aggtgttttt ctcaggtgtt ttccgcgttc 420 cgggtcaaag ttggcgtttt attattatag tcagctgacg tgtagtgtat ttatacccgg 480 tgagttcctc aagaggccac tcttgagtgc cagcgagtag agttttctcc tccgagccgc 540

tccgacaccg ggactgaaaa tgagacatat tatctgccac ggaggtgtta ttaccgaaga 600 aatggccgcc agtcttttgg accagctgat cgaagaggta ctggctgata atcttccacc 660

tcctagccat tttgaaccac ctacccttca cgaactgtat gatttagacg tgacggcccc 720 cgaagatccc aacgaggagg cggtttcgca gatttttccc gactctgtaa tgttggcggt 780 gcaggaaggg attgacttac tcacttttcc gccggcgccc ggttctccgg agccgcctca 840

cctttcccgg cagcccgagc agccggagca gagagccttg ggtccggttt ctatgccaaa 900 Page 19

Sequence_Listing.txt ccttgtaccg gaggtgatcg atcttacctg ccacgaggct ggctttccac ccagtgacga 960

cgaggatgaa gagggtgagg agtttgtgtt agattatgtg gagcaccccg ggcacggttg 1020 caggtcttgt cattatcacc ggaggaatac gggggaccca gatattatgt gttcgctttg 1080

ctatatgagg acctgtggca tgtttgtcta cagtaagtga aaattatggg cagtgggtga 1140 tagagtggtg ggtttggtgt ggtaattttt tttttaattt ttacagtttt gtggtttaaa 1200 gaattttgta ttgtgatttt tttaaaaggt cctgtgtctg aacctgagcc tgagcccgag 1260

ccagaaccgg agcctgcaag acctacccgc cgtcctaaaa tggcgcctgc tatcctgaga 1320 cgcccgacat cacctgtgtc tagagaatgc aatagtagta cggatagctg tgactccggt 1380 ccttctaaca cacctcctga gatacacccg gtggtcccgc tgtgccccat taaaccagtt 1440

gccgtgagag ttggtgggcg tcgccaggct gtggaatgta tcgaggactt gcttaacgag 1500 cctgggcaac ctttggactt gagctgtaaa cgccccaggc caggaagcgg agctactaac 1560 ttcagcctgc tgaagcaggc tggtgacgtc gaggagaatc ctggcccaat ggtgagcaaa 1620

ggcgaagagc tgttcaccgg cgtggtgccc atcctggtgg agctggacgg cgacgtgaac 1680 ggccacaagt tcagcgtgag cggcgagggc gagggcgacg ccacctacgg caagctgacc 1740

ctgaagctgc tgtgcaccac cggcaagctg cccgtgccct ggcccaccct ggtgaccacc 1800

ctgggctacg gcgtgcagtg cttcgcccgg taccccgacc acatgaagca gcacgacttc 1860

ttcaagagcg ccatgcccga gggctacgtg caggagcgga ccatcttctt caaggacgac 1920

ggcaactaca agacccgggc cgaggtgaag ttcgagggcg acaccctggt gaaccggatc 1980 gagctgaagg gcatcgactt caaggaggac ggcaacatcc tgggccacaa gctggagtac 2040

aactacaaca gccacaacgt gtacatcacc gccgacaagc agaagaacgg catcaaggcc 2100

aacttcaaga tccggcacaa catcgaggac ggcggcgtgc agctggccga ccactaccag 2160 cagaacaccc ccatcggcga cggccccgtg ctgctgcccg acaaccacta cctgagctac 2220

cagagcgccc tgttcaagga ccccaacgag aagcgggacc acatggtgct gctggagttc 2280 ctgaccgccg ccggcatcac cgagggcatg aacgagctct ataagtaagg tgtaaacctg 2340 tgattgcgtg tgtggttaac gcctttgttt gctgaatgag ttgatgtaag tttaataaag 2400

ggtgagataa tgtttaactt gcatggcgtg ttaaatgggg cggggcttaa agggtatata 2460 atgcgccgtg ggctaatctt ggttacatct gacctcatgg aggcttggga gtgtttggaa 2520 gatttttctg ctgtgcgtaa cttgctggaa cagagctcta acagtacctc ttggttttgg 2580

aggtttctgt ggggctcatc ccaggcaaag ttagtctgca gaattaagga ggattacaag 2640 tgggaatttg aagagctttt gaaatcctgt ggtgagctgt ttgattcttt gaatctgggt 2700

caccaggcgc ttttccaaga gaaggtcatc aagactttgg atttttccac accggggcgc 2760 gctgcggctg ctgttgcttt tttgagtttt ataaaggata aatggagcga agaaacccat 2820 ctgagcgggg ggtacctgct ggattttctg gccatgcatc tgtggagagc ggttgtgaga 2880

cacaagaatc gcctgctact gttgtcttcc gtccgcccgg cgataatacc gacggaggag 2940 Page 20

Sequence_Listing.txt cagcagcagc agcaggagga agccaggcgg cggcggcagg agcagagccc atggaacccg 3000

agagccggcc tggaccctcg ggaatgaatg ttgtacaggt ggctgaactg tatccagaac 3060 tgagacgcat tttgacaatt acagaggatg ggcaggggct aaagggggta aagagggagc 3120

ggggggcttg tgaggctaca gaggaggcta ggaatctagc ttttagctta atgaccagac 3180 accgtcctga gtgtattact tttcaacaga tcaaggataa ttgcgctaat gagcttgatc 3240 tgctggcgca gaagtattcc atagagcagc tgaccactta ctggctgcag ccaggggatg 3300

attttgagga ggctattagg gtatatgcaa aggtggcact taggccagat tgcaagtaca 3360 agatcagcaa acttgtaaat atcaggaatt gttgctacat ttctgggaac ggggccgagg 3420 tggagataga tacggaggat agggtggcct ttagatgtag catgataaat atgtggccgg 3480

gggtgcttgg catggacggg gtggttatta tgaatgtaag gtttactggc cccaatttta 3540 gcggtacggt tttcctggcc aataccaacc ttatcctaca cggtgtaagc ttctatgggt 3600 ttaacaatac ctgtgtggaa gcctggaccg atgtaagggt tcggggctgt gccttttact 3660

gctgctggaa gggggtggtg tgtcgcccca aaagcagggc ttcaattaag aaatgcctct 3720 ttgaaaggtg taccttgggt atcctgtctg agggtaactc cagggtgcgc cacaatgtgg 3780

cctccgactg tggttgcttc atgctagtga aaagcgtggc tgtgattaag cataacatgg 3840

tatgtggcaa ctgcgaggac agggcctctc agatgctgac ctgctcggac ggcaactgtc 3900

acctgctgaa gaccattcac gtagccagcc actctcgcaa ggcctggcca gtgtttgagc 3960

ataacatact gacccgctgt tccttgcatt tgggtaacag gaggggggtg ttcctacctt 4020 accaatgcaa tttgagtcac actaagatat tgcttgagcc cgagagcatg tccaaggtga 4080

acctgaacgg ggtgtttgac atgaccatga agatctggaa ggtgctgagg tacgatgaga 4140

cccgcaccag gtgcagaccc tgcgagtgtg gcggtaaaca tattaggaac cagcctgtga 4200 tgctggatgt gaccgaggag ctgaggcccg atcacttggt gctggcctgc acccgcgctg 4260

agtttggctc tagcgatgaa gatacagatt gaggtactga aatgtgtggg cgtggcttaa 4320 gggtgggaaa gaatatataa ggtgggggtc ttatgtagtt ttgtatctgt tttgcagcag 4380 ccgccgccgc ccaacttttc tatacaaagt tgtaatgagc accaactcgt ttgatggaag 4440

cattgtgagc tcatatttga caacgcgcat gcccccatgg gccggggtgc gtcagaatgt 4500 gatgggctcc agcattgatg gtcgccccgt cctgcccgca aactctacta ccttgaccta 4560 cgagaccgtg tctggaacgc cgttggagac tgcagcctcc gccgccgctt cagccgctgc 4620

agccaccgcc cgcgggattg tgactgactt tgctttcctg agcccgcttg caagcagtgc 4680 agcttcccgt tcatccgccc gcgatgacaa gttgacggct cttttggcac aattggattc 4740

tttgacccgg gaacttaatg tcgtttctca gcagctgttg gatctgcgcc agcaggtttc 4800 tgccctgaag gcttcctccc ctcccaatgc ggtttaaaac ataaataaaa aaccagactc 4860 tgtttggatt tggatcaagc ataagtgtct tgctgtcttt atttaggggt tttgcgcgcg 4920

cggtaggccc gggaccagcg gtctcggtcg ttgagggtcc tgtgtatttt ttccaggacg 4980 Page 21

Sequence_Listing.txt tggtaaaggt gactctggat gttcagatac atgggcataa gcccgtctct ggggtggagg 5040

tagcaccact gcagagcttc atgctgcggg gtggtgttgt agatgatcca gtcgtagcag 5100 gagcgctggg cgtggtgcct aaaaatgtct ttcagtagca agctgattgc caggggcagg 5160

cccttggtgt aagtgtttac aaagcggtta agctgggatg ggtgcatacg tggggatatg 5220 agatgcatct tggactgtat ttttaggttg gctatgttcc cagccatatc cctccgggga 5280 ttcatgttgt gcagaaccac cagcacagtg tatccggtgc acttgggaaa tttgtcatgt 5340

agcttagaag gaaatgcgtg gaagaacttg gagacgccct tgtgacctcc aagattttcc 5400 atgcattcgt ccataatgat ggcaatgggc ccacgggcgg cggcctgggc gaagatattt 5460 ctgggatcac taacgtcata gttgtgttcc aggatgagat cgtcataggc catttttaca 5520

aagcgcgggc ggagggtgcc agactgcggt ataatggttc catccggccc aggggcgtag 5580 ttaccctcac agatttgcat ttcccacgct ttgagttcag atggggggat catgtctacc 5640 tgcggggcga tgaagaaaac ggtttccggg gtaggggaga tcagctggga agaaagcagg 5700

ttcctgagca gctgcgactt accgcagccg gtgggcccgt aaatcacacc tattaccggg 5760 tgcaactggt agttaagaga gctgcagctg ccgtcatccc tgagcagggg ggccacttcg 5820

ttaagcatgt ccctgactcg catgttttcc ctgaccaaat ccgccagaag gcgctcgccg 5880

cccagcgata gcagttcttg caaggaagca aagtttttca acggtttgag accgtccgcc 5940

gtaggcatgc ttttgagcgt ttgaccaagc agttccaggc ggtcccacag ctcggtcacc 6000

tgctctacgg catctcgatc cagcatatct cctcgtttcg cgggttgggg cggctttcgc 6060 tgtacggcag tagtcggtgc tcgtccagac gggccagggt catgtctttc cacgggcgca 6120

gggtcctcgt cagcgtagtc tgggtcacgg tgaaggggtg cgctccgggc tgcgcgctgg 6180

ccagggtgcg cttgaggctg gtcctgctgg tgctgaagcg ctgccggtct tcgccctgcg 6240 cgtcggccag gtagcatttg accatggtgt catagtccag cccctccgcg gcgtggccct 6300

tggcgcgcag cttgcccttg gaggaggcgc cgcacgaggg gcagtgcaga cttttgaggg 6360 cgtagagctt gggcgcgaga aataccgatt ccggggagta ggcatccgcg ccgcaggccc 6420 cgcagacggt ctcgcattcc acgagccagg tgagctctgg ccgttcgggg tcaaaaacca 6480

ggtttccccc atgctttttg atgcgtttct tacctctggt ttccatgagc cggtgtccac 6540 gctcggtgac gaaaaggctg tccgtgtccc cgtatacaga cttgagaggc ctgtcctcga 6600 gcggtgttcc gcggtcctcc tcgtatagaa actcggacca ctctgagaca aaggctcgcg 6660

tccaggccag cacgaaggag gctaagtggg aggggtagcg gtcgttgtcc actagggggt 6720 ccactcgctc cagggtgtga agacacatgt cgccctcttc ggcatcaagg aaggtgattg 6780

gtttgtaggt gtaggccacg tgaccgggtg ttcctgaagg ggggctataa aagggggtgg 6840 gggcgcgttc gtcctcactc tcttccgcat cgctgtctgc gagggccagc tgttggggtg 6900 agtactccct ctgaaaagcg ggcatgactt ctgcgctaag attgtcagtt tccaaaaacg 6960

aggaggattt gatattcacc tggcccgcgg tgatgccttt gagggtggcc gcatccatct 7020 Page 22

Sequence_Listing.txt ggtcagaaaa gacaatcttt ttgttgtcaa gcttggtggc aaacgacccg tagagggcgt 7080

tggacagcaa cttggcgatg gagcgcaggg tttggttttt gtcgcgatcg gcgcgctcct 7140 tggccgcgat gtttagctgc acgtattcgc gcgcaacgca ccgccattcg ggaaagacgg 7200

tggtgcgctc gtcgggcacc aggtgcacgc gccaaccgcg gttgtgcagg gtgacaaggt 7260 caacgctggt ggctacctct ccgcgtaggc gctcgttggt ccagcagagg cggccgccct 7320 tgcgcgagca gaatggcggt agggggtcta gctgcgtctc gtccgggggg tctgcgtcca 7380

cggtaaagac cccgggcagc aggcgcgcgt cgaagtagtc tatcttgcat ccttgcaagt 7440 ctagcgcctg ctgccatgcg cgggcggcaa gcgcgcgctc gtatgggttg agtgggggac 7500 cccatggcat ggggtgggtg agcgcggagg cgtacatgcc gcaaatgtcg taaacgtaga 7560

ggggctctct gagtattcca agatatgtag ggtagcatct tccaccgcgg atgctggcgc 7620 gcacgtaatc gtatagttcg tgcgagggag cgaggaggtc gggaccgagg ttgctacggg 7680 cgggctgctc tgctcggaag actatctgcc tgaagatggc atgtgagttg gatgatatgg 7740

ttggacgctg gaagacgttg aagctggcgt ctgtgagacc taccgcgtca cgcacgaagg 7800 aggcgtagga gtcgcgcagc ttgttgacca gctcggcggt gacctgcacg tctagggcgc 7860

agtagtccag ggtttccttg atgatgtcat acttatcctg tccctttttt ttccacagct 7920

cgcggttgag gacaaactct tcgcggtctt tccagtactc ttggatcgga aacccgtcgg 7980

cctccgaacg gtaagagcct agcatgtaga actggttgac ggcctggtag gcgcagcatc 8040

ccttttctac gggtagcgcg tatgcctgcg cggccttccg gagcgaggtg tgggtgagcg 8100 caaaggtgtc cctgaccatg actttgaggt actggtattt gaagtcagtg tcgtcgcatc 8160

cgccctgctc ccagagcaaa aagtccgtgc gctttttgga acgcggattt ggcagggcga 8220

aggtgacatc gttgaagagt atctttcccg cgcgaggcat aaagttgcgt gtgatgcgga 8280 agggtcccgg cacctcggaa cggttgttaa ttacctgggc ggcgagcacg atctcgtcaa 8340

agccgttgat gttgtggccc acaatgtaaa gttccaagaa gcgcgggatg cccttgatgg 8400 aaggcaattt tttaagttcc tcgtaggtga gctcttcagg ggagctgagc ccgtgctctg 8460 aaagggccca gtctgcaaga tgagggttgg aagcgacgaa tgagctccac aggtcacggg 8520

ccattagcat ttgcaggtgg tcgcgaaagg tcctaaactg gcgacctatg gccatttttt 8580 ctggggtgat gcagtagaag gtaagcgggt cttgttccca gcggtcccat ccaaggttcg 8640 cggctaggtc tcgcgcggca gtcactagag gctcatctcc gccgaacttc atgaccagca 8700

tgaagggcac gagctgcttc ccaaaggccc ccatccaagt ataggtctct acatcgtagg 8760 tgacaaagag acgctcggtg cgaggatgcg agccgatcgg gaagaactgg atctcccgcc 8820

accaattgga ggagtggcta ttgatgtggt gaaagtagaa gtccctgcga cgggccgaac 8880 actcgtgctg gcttttgtaa aaacgtgcgc agtactggca gcggtgcacg ggctgtacat 8940 cctgcacgag gttgacctga cgaccgcgca caaggaagca gagtgggaat ttgagcccct 9000

cgcctggcgg gtttggctgg tggtcttcta cttcggctgc ttgtccttga ccgtctggct 9060 Page 23

Sequence_Listing.txt gctcgagggg agttacggtg gatcggacca ccacgccgcg cgagcccaaa gtccagatgt 9120

ccgcgcgcgg cggtcggagc ttgatgacaa catcgcgcag atgggagctg tccatggtct 9180 ggagctcccg cggcgtcagg tcaggcggga gctcctgcag gtttacctcg catagacggg 9240

tcagggcgcg ggctagatcc aggtgatacc taatttccag gggctggttg gtggcggcgt 9300 cgatggcttg caagaggccg catccccgcg gcgcgactac ggtaccgcgc ggcgggcggt 9360 gggccgcggg ggtgtccttg gatgatgcat ctaaaagcgg tgacgcgggc gagcccccgg 9420

aggtaggggg ggctccggac ccgccgggag agggggcagg ggcacgtcgg cgccgcgcgc 9480 gggcaggagc tggtgctgcg cgcgtaggtt gctggcgaac gcgacgacgc ggcggttgat 9540 ctcctgaatc tggcgcctct gcgtgaagac gacgggcccg gtgagcttga gcctgaaaga 9600

gagttcgaca gaatcaattt cggtgtcgtt gacggcggcc tggcgcaaaa tctcctgcac 9660 gtctcctgag ttgtcttgat aggcgatctc ggccatgaac tgctcgatct cttcctcctg 9720 gagatctccg cgtccggctc gctccacggt ggcggcgagg tcgttggaaa tgcgggccat 9780

gagctgcgag aaggcgttga ggcctccctc gttccagacg cggctgtaga ccacgccccc 9840 ttcggcatcg cgggcgcgca tgaccacctg cgcgagattg agctccacgt gccgggcgaa 9900

gacggcgtag tttcgcaggc gctgaaagag gtagttgagg gtggtggcgg tgtgttctgc 9960

cacgaagaag tacataaccc agcgtcgcaa cgtggattcg ttgatatccc ccaaggcctc 10020

aaggcgctcc atggcctcgt agaagtccac ggcgaagttg aaaaactggg agttgcgcgc 10080

cgacacggtt aactcctcct ccagaagacg gatgagctcg gcgacagtgt cgcgcacctc 10140 gcgctcaaag gctacagggg cctcttcttc ttcttcaatc tcctcttcca taagggcctc 10200

cccttcttct tcttctggcg gcggtggggg aggggggaca cggcggcgac gacggcgcac 10260

cgggaggcgg tcgacaaagc gctcgatcat ctccccgcgg cgacggcgca tggtctcggt 10320 gacggcgcgg ccgttctcgc gggggcgcag ttggaagacg ccgcccgtca tgtcccggtt 10380

atgggttggc ggggggctgc catgcggcag ggatacggcg ctaacgatgc atctcaacaa 10440 ttgttgtgta ggtactccgc cgccgaggga cctgagcgag tccgcatcga ccggatcgga 10500 aaacctctcg agaaaggcgt ctaaccagtc acagtcgcaa ggtaggctga gcaccgtggc 10560

gggcggcagc gggcggcggt cggggttgtt tctggcggag gtgctgctga tgatgtaatt 10620 aaagtaggcg gtcttgagac ggcggatggt cgacagaagc accatgtcct tgggtccggc 10680 ctgctgaatg cgcaggcggt cggccatgcc ccaggcttcg ttttgacatc ggcgcaggtc 10740

tttgtagtag tcttgcatga gcctttctac cggcacttct tcttctcctt cctcttgtcc 10800 tgcatctctt gcatctatcg ctgcggcggc ggcggagttt ggccgtaggt ggcgccctct 10860

tcctcccatg cgtgtgaccc cgaagcccct catcggctga agcagggcta ggtcggcgac 10920 aacgcgctcg gctaatatgg cctgctgcac ctgcgtgagg gtagactgga agtcatccat 10980 gtccacaaag cggtggtatg cgcccgtgtt gatggtgtaa gtgcagttgg ccataacgga 11040

ccagttaacg gtctggtgac ccggctgcga gagctcggtg tacctgagac gcgagtaagc 11100 Page 24

Sequence_Listing.txt cctcgagtca aatacgtagt cgttgcaagt ccgcaccagg tactggtatc ccaccaaaaa 11160

gtgcggcggc ggctggcggt agaggggcca gcgtagggtg gccggggctc cgggggcgag 11220 atcttccaac ataaggcgat gatatccgta gatgtacctg gacatccagg tgatgccggc 11280

ggcggtggtg gaggcgcgcg gaaagtcgcg gacgcggttc cagatgttgc gcagcggcaa 11340 aaagtgctcc atggtcggga cgctctggcc ggtcaggcgc gcgcaatcgt tgacgctcta 11400 gaccgtgcaa aaggagagcc tgtaagcggg cactcttccg tggtctggtg gataaattcg 11460

caagggtatc atggcggacg accggggttc gagccccgta tccggccgtc cgccgtgatc 11520 catgcggtta ccgcccgcgt gtcgaaccca ggtgtgcgac gtcagacaac gggggagtgc 11580 tccttttggc ttccttccag gcgcggcggc tgctgcgcta gcttttttgg ccactggccg 11640

cgcgcagcgt aagcggttag gctggaaagc gaaagcatta agtggctcgc tccctgtagc 11700 cggagggtta ttttccaagg gttgagtcgc gggacccccg gttcgagtct cggaccggcc 11760 ggactgcggc gaacgggggt ttgcctcccc gtcatgcaag accccgcttg caaattcctc 11820

cggaaacagg gacgagcccc ttttttgctt ttcccagatg catccggtgc tgcggcagat 11880 gcgcccccct cctcagcagc ggcaagagca agagcagcgg cagacatgca gggcaccctc 11940

ccctcctcct accgcgtcag gaggggcgac atccgcggtt gacgcggcag cagatggtga 12000

ttacgaaccc ccgcggcgcc gggcccggca ctacctggac ttggaggagg gcgagggcct 12060

ggcgcggcta ggagcgccct ctcctgagcg gtacccaagg gtgcagctga agcgtgatac 12120

gcgtgaggcg tacgtgccgc ggcagaacct gtttcgcgac cgcgagggag aggagcccga 12180 ggagatgcgg gatcgaaagt tccacgcagg gcgcgagctg cggcatggcc tgaatcgcga 12240

gcggttgctg cgcgaggagg actttgagcc cgacgcgcga accgggatta gtcccgcgcg 12300

cgcacacgtg gcggccgccg acctggtaac cgcatacgag cagacggtga accaggagat 12360 taactttcaa aaaagcttta acaaccacgt gcgtacgctt gtggcgcgcg aggaggtggc 12420

tataggactg atgcatctgt gggactttgt aagcgcgctg gagcaaaacc caaatagcaa 12480 gccgctcatg gcgcagctgt tccttatagt gcagcacagc agggacaacg aggcattcag 12540 ggatgcgctg ctaaacatag tagagcccga gggccgctgg ctgctcgatt tgataaacat 12600

cctgcagagc atagtggtgc aggagcgcag cttgagcctg gctgacaagg tggccgccat 12660 caactattcc atgcttagcc tgggcaagtt ttacgcccgc aagatatacc atacccctta 12720 cgttcccata gacaaggagg taaagatcga ggggttctac atgcgcatgg cgctgaaggt 12780

gcttaccttg agcgacgacc tgggcgttta tcgcaacgag cgcatccaca aggccgtgag 12840 cgtgagccgg cggcgcgagc tcagcgaccg cgagctgatg cacagcctgc aaagggccct 12900

ggctggcacg ggcagcggcg atagagaggc cgagtcctac tttgacgcgg gcgctgacct 12960 gcgctgggcc ccaagccgac gcgccctgga ggcagctggg gccggacctg ggctggcggt 13020 ggcacccgcg cgcgctggca acgtcggcgg cgtggaggaa tatgacgagg acgatgagta 13080

cgagccagag gacggcgagt actaagcggt gatgtttctg atcagatgat gcaagacgca 13140 Page 25

Sequence_Listing.txt acggacccgg cggtgcgggc ggcgctgcag agccagccgt ccggccttaa ctccacggac 13200

gactggcgcc aggtcatgga ccgcatcatg tcgctgactg cgcgcaatcc tgacgcgttc 13260 cggcagcagc cgcaggccaa ccggctctcc gcaattctgg aagcggtggt cccggcgcgc 13320

gcaaacccca cgcacgagaa ggtgctggcg atcgtaaacg cgctggccga aaacagggcc 13380 atccggcccg acgaggccgg cctggtctac gacgcgctgc ttcagcgcgt ggctcgttac 13440 aacagcggca acgtgcagac caacctggac cggctggtgg gggatgtgcg cgaggccgtg 13500

gcgcagcgtg agcgcgcgca gcagcagggc aacctgggct ccatggttgc actaaacgcc 13560 ttcctgagta cacagcccgc caacgtgccg cggggacagg aggactacac caactttgtg 13620 agcgcactgc ggctaatggt gactgagaca ccgcaaagtg aggtgtacca gtctgggcca 13680

gactattttt tccagaccag tagacaaggc ctgcagaccg taaacctgag ccaggctttc 13740 aaaaacttgc aggggctgtg gggggtgcgg gctcccacag gcgaccgcgc gaccgtgtct 13800 agcttgctga cgcccaactc gcgcctgttg ctgctgctaa tagcgccctt cacggacagt 13860

ggcagcgtgt cccgggacac atacctaggt cacttgctga cactgtaccg cgaggccata 13920 ggtcaggcgc atgtggacga gcatactttc caggagatta caagtgtcag ccgcgcgctg 13980

gggcaggagg acacgggcag cctggaggca accctaaact acctgctgac caaccggcgg 14040

cagaagatcc cctcgttgca cagtttaaac agcgaggagg agcgcatttt gcgctacgtg 14100

cagcagagcg tgagccttaa cctgatgcgc gacggggtaa cgcccagcgt ggcgctggac 14160

atgaccgcgc gcaacatgga accgggcatg tatgcctcaa accggccgtt tatcaaccgc 14220 ctaatggact acttgcatcg cgcggccgcc gtgaaccccg agtatttcac caatgccatc 14280

ttgaacccgc actggctacc gccccctggt ttctacaccg ggggattcga ggtgcccgag 14340

ggtaacgatg gattcctctg ggacgacata gacgacagcg tgttttcccc gcaaccgcag 14400 accctgctag agttgcaaca gcgcgagcag gcagaggcgg cgctgcgaaa ggaaagcttc 14460

cgcaggccaa gcagcttgtc cgatctaggc gctgcggccc cgcggtcaga tgctagtagc 14520 ccatttccaa gcttgatagg gtctcttacc agcactcgca ccacccgccc gcgcctgctg 14580 ggcgaggagg agtacctaaa caactcgctg ctgcagccgc agcgcgaaaa aaacctgcct 14640

ccggcatttc ccaacaacgg gatagagagc ctagtggaca agatgagtag atggaagacg 14700 tacgcgcagg agcacaggga cgtgccaggc ccgcgcccgc ccacccgtcg tcaaaggcac 14760 gaccgtcagc ggggtctggt gtgggaggac gatgactcgg cagacgacag cagcgtcctg 14820

gatttgggag ggagtggcaa cccgtttgcg caccttcgcc ccaggctggg gagaatgttt 14880 taaaaaaaaa aaagcatgat gcaaaataaa aaactcacca aggccatggc accgagcgtt 14940

ggttttcttg tattcccctt agtatgcggc gcgcggcgat gtatgaggaa ggtcctcctc 15000 cctcctacga gagtgtggtg agcgcggcgc cagtggcggc ggcgctgggt tctcccttcg 15060 atgctcccct ggacccgccg tttgtgcctc cgcggtacct gcggcctacc ggggggagaa 15120

acagcatccg ttactctgag ttggcacccc tattcgacac cacccgtgtg tacctggtgg 15180 Page 26

Sequence_Listing.txt acaacaagtc aacggatgtg gcatccctga actaccagaa cgaccacagc aactttctga 15240

ccacggtcat tcaaaacaat gactacagcc cgggggaggc aagcacacag accatcaatc 15300 ttgacgaccg gtcgcactgg ggcggcgacc tgaaaaccat cctgcatacc aacatgccaa 15360

atgtgaacga gttcatgttt accaataagt ttaaggcgcg ggtgatggtg tcgcgcttgc 15420 ctactaagga caatcaggtg gagctgaaat acgagtgggt ggagttcacg ctgcccgagg 15480 gcaactactc cgagaccatg accatagacc ttatgaacaa cgcgatcgtg gagcactact 15540

tgaaagtggg cagacagaac ggggttctgg aaagcgacat cggggtaaag tttgacaccc 15600 gcaacttcag actggggttt gaccccgtca ctggtcttgt catgcctggg gtatatacaa 15660 acgaagcctt ccatccagac atcattttgc tgccaggatg cggggtggac ttcacccaca 15720

gccgcctgag caacttgttg ggcatccgca agcggcaacc cttccaggag ggctttagga 15780 tcacctacga tgatctggag ggtggtaaca ttcccgcact gttggatgtg gacgcctacc 15840 aggcgagctt gaaagatgac accgaacagg gcgggggtgg cgcaggcggc agcaacagca 15900

gtggcagcgg cgcggaagag aactccaacg cggcagccgc ggcaatgcag ccggtggagg 15960 acatgaacga tcatgccatt cgcggcgaca cctttgccac acgggctgag gagaagcgcg 16020

ctgaggccga agcagcggcc gaagctgccg cccccgctgc gcaacccgag gtcgagaagc 16080

ctcagaagaa accggtgatc aaacccctga cagaggacag caagaaacgc agttacaacc 16140

taataagcaa tgacagcacc ttcacccagt accgcagctg gtaccttgca tacaactacg 16200

gcgaccctca gaccggaatc cgctcatgga ccctgctttg cactcctgac gtaacctgcg 16260 gctcggagca ggtctactgg tcgttgccag acatgatgca agaccccgtg accttccgct 16320

ccacgcgcca gatcagcaac tttccggtgg tgggcgccga gctgttgccc gtgcactcca 16380

agagcttcta caacgaccag gccgtctact cccaactcat ccgccagttt acctctctga 16440 cccacgtgtt caatcgcttt cccgagaacc agattttggc gcgcccgcca gcccccacca 16500

tcaccaccgt cagtgaaaac gttcctgctc tcacagatca cgggacgcta ccgctgcgca 16560 acagcatcgg aggagtccag cgagtgacca ttactgacgc cagacgccgc acctgcccct 16620 acgtttacaa ggccctgggc atagtctcgc cgcgcgtcct atcgagccgc actttttgag 16680

caagcatgtc catccttata tcgcccagca ataacacagg ctggggcctg cgcttcccaa 16740 gcaagatgtt tggcggggcc aagaagcgct ccgaccaaca cccagtgcgc gtgcgcgggc 16800 actaccgcgc gccctggggc gcgcacaaac gcggccgcac tgggcgcacc accgtcgatg 16860

acgccatcga cgcggtggtg gaggaggcgc gcaactacac gcccacgccg ccaccagtgt 16920 ccacagtgga cgcggccatt cagaccgtgg tgcgcggagc ccggcgctat gctaaaatga 16980

agagacggcg gaggcgcgta gcacgtcgcc accgccgccg acccggcact gccgcccaac 17040 gcgcggcggc ggccctgctt aaccgcgcac gtcgcaccgg ccgacgggcg gccatgcggg 17100 ccgctcgaag gctggccgcg ggtattgtca ctgtgccccc caggtccagg cgacgagcgg 17160

ccgccgcagc agccgcggcc attagtgcta tgactcaggg tcgcaggggc aacgtgtatt 17220 Page 27

Sequence_Listing.txt gggtgcgcga ctcggttagc ggcctgcgcg tgcccgtgcg cacccgcccc ccgcgcaact 17280

agattgcaag aaaaaactac ttagactcgt actgttgtat gtatccagcg gcggcggcgc 17340 gcaacgaagc tatgtccaag cgcaaaatca aagaagagat gctccaggtc atcgcgccgg 17400

agatctatgg ccccccgaag aaggaagagc aggattacaa gccccgaaag ctaaagcggg 17460 tcaaaaagaa aaagaaagat gatgatgatg aacttgacga cgaggtggaa ctgctgcacg 17520 ctaccgcgcc caggcgacgg gtacagtgga aaggtcgacg cgtaaaacgt gttttgcgac 17580

ccggcaccac cgtagtcttt acgcccggtg agcgctccac ccgcacctac aagcgcgtgt 17640 atgatgaggt gtacggcgac gaggacctgc ttgagcaggc caacgagcgc ctcggggagt 17700 ttgcctacgg aaagcggcat aaggacatgc tggcgttgcc gctggacgag ggcaacccaa 17760

cacctagcct aaagcccgta acactgcagc aggtgctgcc cgcgcttgca ccgtccgaag 17820 aaaagcgcgg cctaaagcgc gagtctggtg acttggcacc caccgtgcag ctgatggtac 17880 ccaagcgcca gcgactggaa gatgtcttgg aaaaaatgac cgtggaacct gggctggagc 17940

ccgaggtccg cgtgcggcca atcaagcagg tggcgccggg actgggcgtg cagaccgtgg 18000 acgttcagat acccactacc agtagcacca gtattgccac cgccacagag ggcatggaga 18060

cacaaacgtc cccggttgcc tcagcggtgg cggatgccgc ggtgcaggcg gtcgctgcgg 18120

ccgcgtccaa gacctctacg gaggtgcaaa cggacccgtg gatgtttcgc gtttcagccc 18180

cccggcgccc gcgcggttcg aggaagtacg gcgccgccag cgcgctactg cccgaatatg 18240

ccctacatcc ttccattgcg cctacccccg gctatcgtgg ctacacctac cgccccagaa 18300 gacgagcaac tacccgacgc cgaaccacca ctggaacccg ccgccgccgt cgccgtcgcc 18360

agcccgtgct ggccccgatt tccgtgcgca gggtggctcg cgaaggaggc aggaccctgg 18420

tgctgccaac agcgcgctac caccccagca tcgtttaaaa gccggtcttt gtggttcttg 18480 cagatatggc cctcacctgc cgcctccgtt tcccggtgcc gggattccga ggaagaatgc 18540

accgtaggag gggcatggcc ggccacggcc tgacgggcgg catgcgtcgt gcgcaccacc 18600 ggcggcggcg cgcgtcgcac cgtcgcatgc gcggcggtat cctgcccctc cttattccac 18660 tgatcgccgc ggcgattggc gccgtgcccg gaattgcatc cgtggccttg caggcgcaga 18720

gacactgatt aaaaacaagt tgcatgtgga aaaatcaaaa taaaaagtct ggactctcac 18780 gctcgcttgg tcctgtaact attttgtaga atggaagaca tcaactttgc gtctctggcc 18840 ccgcgacacg gctcgcgccc gttcatggga aactggcaag atatcggcac cagcaatatg 18900

agcggtggcg ccttcagctg gggctcgctg tggagcggca ttaaaaattt cggttccacc 18960 gttaagaact atggcagcaa ggcctggaac agcagcacag gccagatgct gagggataag 19020

ttgaaagagc aaaatttcca acaaaaggtg gtagatggcc tggcctctgg cattagcggg 19080 gtggtggacc tggccaacca ggcagtgcaa aataagatta acagtaagct tgatccccgc 19140 cctcccgtag aggagcctcc accggccgtg gagacagtgt ctccagaggg gcgtggcgaa 19200

aagcgtccgc gccccgacag ggaagaaact ctggtgacgc aaatagacga gcctccctcg 19260 Page 28

Sequence_Listing.txt tacgaggagg cactaaagca aggcctgccc accacccgtc ccatcgcgcc catggctacc 19320

ggagtgctgg gccagcacac acccgtaacg ctggacctgc ctccccccgc cgacacccag 19380 cagaaacctg tgctgccagg cccgaccgcc gttgttgtaa cccgtcctag ccgcgcgtcc 19440

ctgcgccgcg ccgccagcgg tccgcgatcg ttgcggcccg tagccagtgg caactggcaa 19500 agcacactga acagcatcgt gggtctgggg gtgcaatccc tgaagcgccg acgatgcttc 19560 tgaatagcta acgtgtcgta tgtgtgtcat gtatgcgtcc atgtcgccgc cagaggagct 19620

gctgagccgc cgcgcgcccg ctttccaaga tggctacccc ttcgatgatg ccgcagtggt 19680 cttacatgca catctcgggc caggacgcct cggagtacct gagccccggg ctggtgcagt 19740 ttgcccgcgc caccgagacg tacttcagcc tgaataacaa gtttagaaac cccacggtgg 19800

cgcctacgca cgacgtgacc acagaccggt cccagcgttt gacgctgcgg ttcatccctg 19860 tggaccgtga ggatactgcg tactcgtaca aggcgcggtt caccctagct gtgggtgata 19920 accgtgtgct ggacatggct tccacgtact ttgacatccg cggcgtgctg gacaggggcc 19980

ctacttttaa gccctactct ggcactgcct acaacgccct ggctcccaag ggtgccccaa 20040 atccttgcga atgggatgaa gctgctactg ctcttgaaat aaacctagaa gaagaggacg 20100

atgacaacga agacgaagta gacgagcaag ctgagcagca aaaaactcac gtatttgggc 20160

aggcgcctta ttctggtata aatattacaa aggagggtat tcaaataggt gtcgaaggtc 20220

aaacacctaa atatgccgat aaaacatttc aacctgaacc tcaaatagga gaatctcagt 20280

ggtacgaaac tgaaattaat catgcagctg ggagagtcct taaaaagact accccaatga 20340 aaccatgtta cggttcatat gcaaaaccca caaatgaaaa tggagggcaa ggcattcttg 20400

taaagcaaca aaatggaaag ctagaaagtc aagtggaaat gcaatttttc tcaactactg 20460

aggcgaccgc aggcaatggt gataacttga ctcctaaagt ggtattgtac agtgaagatg 20520 tagatataga aaccccagac actcatattt cttacatgcc cactattaag gaaggtaact 20580

cacgagaact aatgggccaa caatctatgc ccaacaggcc taattacatt gcttttaggg 20640 acaattttat tggtctaatg tattacaaca gcacgggtaa tatgggtgtt ctggcgggcc 20700 aagcatcgca gttgaatgct gttgtagatt tgcaagacag aaacacagag ctttcatacc 20760

agcttttgct tgattccatt ggtgatagaa ccaggtactt ttctatgtgg aatcaggctg 20820 ttgacagcta tgatccagat gttagaatta ttgaaaatca tggaactgaa gatgaacttc 20880 caaattactg ctttccactg ggaggtgtga ttaatacaga gactcttacc aaggtaaaac 20940

ctaaaacagg tcaggaaaat ggatgggaaa aagatgctac agaattttca gataaaaatg 21000 aaataagagt tggaaataat tttgccatgg aaatcaatct aaatgccaac ctgtggagaa 21060

atttcctgta ctccaacata gcgctgtatt tgcccgacaa gctaaagtac agtccttcca 21120 acgtaaaaat ttctgataac ccaaacacct acgactacat gaacaagcga gtggtggctc 21180 ccgggttagt ggactgctac attaaccttg gagcacgctg gtcccttgac tatatggaca 21240

acgtcaaccc atttaaccac caccgcaatg ctggcctgcg ctaccgctca atgttgctgg 21300 Page 29

Sequence_Listing.txt gcaatggtcg ctatgtgccc ttccacatcc aggtgcctca gaagttcttt gccattaaaa 21360

acctccttct cctgccgggc tcatacacct acgagtggaa cttcaggaag gatgttaaca 21420 tggttctgca gagctcccta ggaaatgacc taagggttga cggagccagc attaagtttg 21480

atagcatttg cctttacgcc accttcttcc ccatggccca caacaccgcc tccacgcttg 21540 aggccatgct tagaaacgac accaacgacc agtcctttaa cgactatctc tccgccgcca 21600 acatgctcta ccctataccc gccaacgcta ccaacgtgcc catatccatc ccctcccgca 21660

actgggcggc tttccgcggc tgggccttca cgcgccttaa gactaaggaa accccatcac 21720 tgggctcggg ctacgaccct tattacacct actctggctc tataccctac ctagatggaa 21780 ccttttacct caaccacacc tttaagaagg tggccattac ctttgactct tctgtcagct 21840

ggcctggcaa tgaccgcctg cttaccccca acgagtttga aattaagcgc tcagttgacg 21900 gggagggtta caacgttgcc cagtgtaaca tgaccaaaga ctggttcctg gtacaaatgc 21960 tagctaacta caacattggc taccagggct tctatatccc agagagctac aaggaccgca 22020

tgtactcctt ctttagaaac ttccagccca tgagccgtca ggtggtggat gatactaaat 22080 acaaggacta ccaacaggtg ggcatcctac accaacacaa caactctgga tttgttggct 22140

accttgcccc caccatgcgc gaaggacagg cctaccctgc taacttcccc tatccgctta 22200

taggcaagac cgcagttgac agcattaccc agaaaaagtt tctttgcgat cgcacccttt 22260

ggcgcatccc attctccagt aactttatgt ccatgggcgc actcacagac ctgggccaaa 22320

accttctcta cgccaactcc gcccacgcgc tagacatgac ttttgaggtg gatcccatgg 22380 acgagcccac ccttctttat gttttgtttg aagtctttga cgtggtccgt gtgcaccggc 22440

cgcaccgcgg cgtcatcgaa accgtgtacc tgcgcacgcc cttctcggcc ggcaacgcca 22500

caacataaag aagcaagcaa catcaacaac agctgccgcc atgggctcca gtgagcagga 22560 actgaaagcc attgtcaaag atcttggttg tgggccatat tttttgggca cctatgacaa 22620

gcgctttcca ggctttgttt ctccacacaa gctcgcctgc gccatagtca atacggccgg 22680 tcgcgagact gggggcgtac actggatggc ctttgcctgg aacccgcact caaaaacatg 22740 ctacctcttt gagccctttg gcttttctga ccagcgactc aagcaggttt accagtttga 22800

gtacgagtca ctcctgcgcc gtagcgccat tgcttcttcc cccgaccgct gtataacgct 22860 ggaaaagtcc acccaaagcg tacaggggcc caactcggcc gcctgtggac tattctgctg 22920 catgtttctc cacgcctttg ccaactggcc ccaaactccc atggatcaca accccaccat 22980

gaaccttatt accggggtac ccaactccat gctcaacagt ccccaggtac agcccaccct 23040 gcgtcgcaac caggaacagc tctacagctt cctggagcgc cactcgccct acttccgcag 23100

ccacagtgcg cagattagga gcgccacttc tttttgtcac ttgaaaaaca tgtaaaaata 23160 atgtactaga gacactttca ataaaggcaa atgcttttat ttgtacactc tcgggtgatt 23220 atttaccccc acccttgccg tctgcgccgt ttaaaaatca aaggggttct gccgcgcatc 23280

gctatgcgcc actggcaggg acacgttgcg atactggtgt ttagtgctcc acttaaactc 23340 Page 30

Sequence_Listing.txt aggcacaacc atccgcggca gctcggtgaa gttttcactc cacaggctgc gcaccatcac 23400

caacgcgttt agcaggtcgg gcgccgatat cttgaagtcg cagttggggc ctccgccctg 23460 cgcgcgcgag ttgcgataca cagggttgca gcactggaac actatcagcg ccgggtggtg 23520

cacgctggcc agcacgctct tgtcggagat cagatccgcg tccaggtcct ccgcgttgct 23580 cagggcgaac ggagtcaact ttggtagctg ccttcccaaa aagggcgcgt gcccaggctt 23640 tgagttgcac tcgcaccgta gtggcatcaa aaggtgaccg tgcccggtct gggcgttagg 23700

atacagcgcc tgcataaaag ccttgatctg cttaaaagcc acctgagcct ttgcgccttc 23760 agagaagaac atgccgcaag acttgccgga aaactgattg gccggacagg ccgcgtcgtg 23820 cacgcagcac cttgcgtcgg tgttggagat ctgcaccaca tttcggcccc accggttctt 23880

cacgatcttg gccttgctag actgctcctt cagcgcgcgc tgcccgtttt cgctcgtcac 23940 atccatttca atcacgtgct ccttatttat cataatgctt ccgtgtagac acttaagctc 24000 gccttcgatc tcagcgcagc ggtgcagcca caacgcgcag cccgtgggct cgtgatgctt 24060

gtaggtcacc tctgcaaacg actgcaggta cgcctgcagg aatcgcccca tcatcgtcac 24120 aaaggtcttg ttgctggtga aggtcagctg caacccgcgg tgctcctcgt tcagccaggt 24180

cttgcatacg gccgccagag cttccacttg gtcaggcagt agtttgaagt tcgcctttag 24240

atcgttatcc acgtggtact tgtccatcag cgcgcgcgca gcctccatgc ccttctccca 24300

cgcagacacg atcggcacac tcagcgggtt catcaccgta atttcacttt ccgcttcgct 24360

gggctcttcc tcttcctctt gcgtccgcat accacgcgcc actgggtcgt cttcattcag 24420 ccgccgcact gtgcgcttac ctcctttgcc atgcttgatt agcaccggtg ggttgctgaa 24480

acccaccatt tgtagcgcca catcttctct ttcttcctcg ctgtccacga ttacctctgg 24540

tgatggcggg cgctcgggct tgggagaagg gcgcttcttt ttcttcttgg gcgcaatggc 24600 caaatccgcc gccgaggtcg atggccgcgg gctgggtgtg cgcggcacca gcgcgtcttg 24660

tgatgagtct tcctcgtcct cggactcgat acgccgcctc atccgctttt ttgggggcgc 24720 ccggggaggc ggcggcgacg gggacgggga cgacacgtcc tccatggttg ggggacgtcg 24780 cgccgcaccg cgtccgcgct cgggggtggt ttcgcgctgc tcctcttccc gactggccat 24840

ttccttctcc tataggcaga aaaagatcat ggagtcagtc gagaagaagg acagcctaac 24900 cgccccctct gagttcgcca ccaccgcctc caccgatgcc gccaacgcgc ctaccacctt 24960 ccccgtcgag gcacccccgc ttgaggagga ggaagtgatt atcgagcagg acccaggttt 25020

tgtaagcgaa gacgacgagg accgctcagt accaacagag gataaaaagc aagaccagga 25080 caacgcagag gcaaacgagg aacaagtcgg gcggggggac gaaaggcatg gcgactacct 25140

agatgtggga gacgacgtgc tgttgaagca tctgcagcgc cagtgcgcca ttatctgcga 25200 cgcgttgcaa gagcgcagcg atgtgcccct cgccatagcg gatgtcagcc ttgcctacga 25260 acgccaccta ttctcaccgc gcgtaccccc caaacgccaa gaaaacggca catgcgagcc 25320

caacccgcgc ctcaacttct accccgtatt tgccgtgcca gaggtgcttg ccacctatca 25380 Page 31

Sequence_Listing.txt catctttttc caaaactgca agatacccct atcctgccgt gccaaccgca gccgagcgga 25440

caagcagctg gccttgcggc agggcgctgt catacctgat atcgcctcgc tcaacgaagt 25500 gccaaaaatc tttgagggtc ttggacgcga cgagaagcgc gcggcaaacg ctctgcaaca 25560

ggaaaacagc gaaaatgaaa gtcactctgg agtgttggtg gaactcgagg gtgacaacgc 25620 gcgcctagcc gtactaaaac gcagcatcga ggtcacccac tttgcctacc cggcacttaa 25680 cctacccccc aaggtcatga gcacagtcat gagtgagctg atcgtgcgcc gtgcgcagcc 25740

cctggagagg gatgcaaatt tgcaagaaca aacagaggag ggcctacccg cagttggcga 25800 cgagcagcta gcgcgctggc ttcaaacgcg cgagcctgcc gacttggagg agcgacgcaa 25860 actaatgatg gccgcagtgc tcgttaccgt ggagcttgag tgcatgcagc ggttctttgc 25920

tgacccggag atgcagcgca agctagagga aacattgcac tacacctttc gacagggcta 25980 cgtacgccag gcctgcaaga tctccaacgt ggagctctgc aacctggtct cctaccttgg 26040 aattttgcac gaaaaccgcc ttgggcaaaa cgtgcttcat tccacgctca agggcgaggc 26100

gcgccgcgac tacgtccgcg actgcgttta cttatttcta tgctacacct ggcagacggc 26160 catgggcgtt tggcagcagt gcttggagga gtgcaacctc aaggagctgc agaaactgct 26220

aaagcaaaac ttgaaggacc tatggacggc cttcaacgag cgctccgtgg ccgcgcacct 26280

ggcggacatc attttccccg aacgcctgct taaaaccctg caacagggtc tgccagactt 26340

caccagtcaa agcatgttgc agaactttag gaactttatc ctagagcgct caggaatctt 26400

gcccgccacc tgctgtgcac ttcctagcga ctttgtgccc attaagtacc gcgaatgccc 26460 tccgccgctt tggggccact gctaccttct gcagctagcc aactaccttg cctaccactc 26520

tgacataatg gaagacgtga gcggtgacgg tctactggag tgtcactgtc gctgcaacct 26580

atgcaccccg caccgctccc tggtttgcaa ttcgcagctg cttaacgaaa gtcaaattat 26640 cggtaccttt gagctgcagg gtccctcgcc tgacgaaaag tccgcggctc cggggttgaa 26700

actcactccg gggctgtgga cgtcggctta ccttcgcaaa tttgtacctg aggactacca 26760 cgcccacgag attaggttct acgaagacca atcccgcccg ccaaatgcgg agcttaccgc 26820 ctgcgtcatt acccagggcc acattcttgg ccaattgcaa gccatcaaca aagcccgcca 26880

agagtttctg ctacgaaagg gacggggggt ttacttggac ccccagtccg gcgaggagct 26940 caacccaatc cccccgccgc cgcagcccta tcagcagcag ccgcgggccc ttgcttccca 27000 ggatggcacc caaaaagaag ctgcagctgc cgccgccacc cacggacgag gaggaatact 27060

gggacagtca ggcagaggag gttttggacg aggaggagga ggacatgatg gaagactggg 27120 agagcctaga cgaggaagct tccgaggtcg aagaggtgtc agacgaaaca ccgtcaccct 27180

cggtcgcatt cccctcgccg gcgccccaga aatcggcaac cggttccagc atggctacaa 27240 cctccgctcc tcaggcgccg ccggcactgc ccgttcgccg acccaaccgt agatgggaca 27300 ccactggaac cagggccggt aagtccaagc agccgccgcc gttagcccaa gagcaacaac 27360

agcgccaagg ctaccgctca tggcgcgggc acaagaacgc catagttgct tgcttgcaag 27420 Page 32

Sequence_Listing.txt actgtggggg caacatctcc ttcgcccgcc gctttcttct ctaccatcac ggcgtggcct 27480

tcccccgtaa catcctgcat tactaccgtc atctctacag cccatactgc accggcggca 27540 gcggcagcgg cagcaacagc agcggccaca cagaagcaaa ggcgaccgga tagcaagact 27600

ctgacaaagc ccaagaaatc cacagcggcg gcagcagcag gaggaggagc gctgcgtctg 27660 gcgcccaacg aacccgtatc gacccgcgag cttagaaaca ggatttttcc cactctgtat 27720 gctatatttc aacagagcag gggccaagaa caagagctga aaataaaaaa caggtctctg 27780

cgatccctca cccgcagctg cctgtatcac aaaagcgaag atcagcttcg gcgcacgctg 27840 gaagacgcgg aggctctctt cagtaaatac tgcgcgctga ctcttaagga ctagtttcgc 27900 gccctttctc aaatttaagc gcgaaaacta cgtcatctcc agcggccaca cccggcgcca 27960

gcacctgtcg tcagcgccat ttcaactttg tatacaaaag ttgtgatgag caaggaaatt 28020 cccacgccct acatgtggag ttaccagcca caaatgggac ttgcggctgg agctgcccaa 28080 gactactcaa cccgaataaa ctacatgagc gcgggacccc acatgatatc ccgggtcaac 28140

ggaatacgcg cccaccgaaa ccgaattctc ctggaacagg cggctattac caccacacct 28200 cgtaataacc ttaatccccg tagttggccc gctgccctgg tgtaccagga aagtcccgct 28260

cccaccactg tggtacttcc cagagacgcc caggccgaag ttcagatgac taactcaggg 28320

gcgcagcttg cgggcggctt tcgtcacagg gtgcggtcgc ccgggcaggg tataactcac 28380

ctgacaatca gagggcgagg tattcagctc aacgacgagt cggtgagctc ctcgcttggt 28440

ctccgtccgg acgggacatt tcagatcggc ggcgccggcc gctcttcatt cacgcctcgt 28500 caggcaatcc taactctgca gacctcgtcc tctgagccgc gctctggagg cattggaact 28560

ctgcaattta ttgaggagtt tgtgccatcg gtctacttta accccttctc gggacctccc 28620

ggccactatc cggatcaatt tattcctaac tttgacgcgg taaaggactc ggcggacggc 28680 tacgactgaa tgttaagtgg agaggcagag caactgcgcc tgaaacacct ggtccactgt 28740

cgccgccaca agtgctttgc ccgcgactcc ggtgagtttt gctactttga attgcccgag 28800 gatcatatcg agggcccggc gcacggcgtc cggcttaccg cccagggaga gcttgcccgt 28860 agcctgattc gggagtttac ccagcgcccc ctgctagttg agcgggacag gggaccctgt 28920

gttctcactg tgatttgcaa ctgtcctaac cctggattac atcaagatct ttgttgccat 28980 ctctgtgctg agtataataa atacagaaat taaaatatac tggggctcct atcgccatcc 29040 tgtaaacgcc accgtcttca cccgcccaag caaaccaagg cgaaccttac ctggtacttt 29100

taacatctct ccctctgtga tttacaacag tttcaaccca gacggagtga gtctacgaga 29160 gaacctctcc gagctcagct actccatcag aaaaaacacc accctcctta cctgccggga 29220

acgtacgagt gcgtcaccgg ccgctgcacc acacctaccg cctgaccgta aaccagactt 29280 tttccggaca gacctcaata actctgttta ccagaacagg aggtgagctt agaaaaccct 29340 tagggtatta ggccaaaggc gcagctactg tggggtttat gaacaattca agcaactcta 29400

cgggctattc taattcaggt ttctctagaa tcggggttgg ggttattctc tgtcttgtga 29460 Page 33

Sequence_Listing.txt ttctctttat tcttatacta acgcttctct gcctaaggct cgccgcctgc tgtgtgcaca 29520

tttgcattta ttgtcagctt tttaaacgct ggggtcgcca cccaagatga ttaggtacat 29580 aatcctaggt ttactcaccc ttgcgtcagc ccacggtacc acccaaaagg tggattttaa 29640

ggagccagcc tgtaatgtta cattcgcagc tgaagctaat gagtgcacca ctcttataaa 29700 atgcaccaca gaacatgaaa agctgcttat tcgccacaaa aacaaaattg gcaagtatgc 29760 tgtttatgct atttggcagc caggtgacac tacagagtat aatgttacag ttttccaggg 29820

taaaagtcat aaaactttta tgtatacttt tccattttat gaaatgtgcg acattaccat 29880 gtacatgagc aaacagtata agttgtggcc cccacaaaat tgtgtggaaa acactggcac 29940 tttctgctgc actgctatgc taattacagt gctcgctttg gtctgtaccc tactctatat 30000

taaatacaaa agcagacgca gctttattga ggaaaagaaa atgccttaat ttactaagtt 30060 acaaagctaa tgtcaccact aactgcttta ctcgctgctt gcaaaacaaa ttcaaaaagt 30120 tagcattata attagaatag gatttaaacc ccccggtcat ttcctgctca ataccattcc 30180

cctgaacaat tgactctatg tgggatatgc tccagcgcta caaccttgaa gtcaggcttc 30240 ctggatgtca gcatctgact ttggccagca cctgtcccgc ggatttgttc cagtccaact 30300

acagcgaccc accctaacag agatgaccaa cacaaccaac gcggccgccg ctaccggact 30360

tacatctacc acaaatacac cccaagtttc tgcctttgtc aataactggg ataacttggg 30420

catgtggtgg ttctccatag cgcttatgtt tgtatgcctt attattatgt ggctcatctg 30480

ctgcctaaag cgcaaacgcg cccgaccacc catctatagt cccatcattg tgctacaccc 30540 aaacaatgat ggaatccata gattggacgg actgaaacac atgttctttt ctcttacagt 30600

atgattaaat gagacatgat tcctcgagtt tttatattac tgacccttgt tgcgcttttt 30660

tgtgcgtgct ccacattggc tgcggtttct cacatcgaag tagactgcat tccagccttc 30720 acagtctatt tgctttacgg atttgtcacc ctcacgctca tctgcagcct catcactgtg 30780

gtcatcgcct ttatccagtg cattgactgg gtctgtgtgc gctttgcata tctcagacac 30840 catccccagt acagggacag gactatagct gagcttctta gaattcttta attatgaaat 30900 ttactgtgac ttttctgctg attatttgca ccctatctgc gttttgttcc ccgacctcca 30960

agcctcaaag acatatatca tgcagattca ctcgtatatg gaatattcca agttgctaca 31020 atgaaaaaag cgatctttcc gaagcctggt tatatgcaat catctctgtt atggtgttct 31080 gcagtaccat cttagcccta gctatatatc cctaccttga cattggctgg aacgcaatag 31140

atgccatgaa ccacccaact ttccccgcgc ccgctatgct tccactgcaa caagttgttg 31200 ccggcggctt tgtcccagcc aatcagcctc gcccaccttc tcccaccccc actgaaatca 31260

gctactttaa tctaacagga ggagatgact gacaccctag atctagaaat ggacggaatt 31320 attacagagc agcgcctgct agaaagacgc agggcagcgg ccgagcaaca gcgcatgaat 31380 caagagctcc aagacatggt taacttgcac cagtgcaaaa ggggtatctt ttgtctggta 31440

aagcaggcca aagtcaccta cgacagtaat accaccggac accgccttag ctacaagttg 31500 Page 34

Sequence_Listing.txt ccaaccaagc gtcagaaatt ggtggtcatg gtgggagaaa agcccattac cataactcag 31560

cactcggtag aaaccgaagg ctgcattcac tcaccttgtc aaggacctga ggatctctgc 31620 acccttatta agaccctgtg cggtctcaaa gatcttattc cctttaacta ataaaaaaaa 31680

ataataaagc atcacttact taaaatcagt tagcaaattt ctgtccagtt tattcagcag 31740 cacctccttg ccctcctccc agctctggta ttgcagcttc ctcctggctg caaactttct 31800 ccacaatcta aatggaatgt cagtttcctc ctgttcctgt ccatccgcac ccactatctt 31860

catgttgttg cagatgaagc gcgcaagacc gtctgaagat accttcaacc ccgtgtatcc 31920 atatgacacg gaaaccggtc ctccaactgt gccttttctt actcctccct ttgtatcccc 31980 caatgggttt caagagagtc cccctggggt actctctttg cgcctatccg aacctctagt 32040

tacctccaat ggcatgcttg cgctcaaaat gggcaacggc ctctctctgg acgaggccgg 32100 caaccttacc tcccaaaatg taaccactgt gagcccacct ctcaaaaaaa ccaagtcaaa 32160 cataaacctg gaaatatctg cacccctcac agttacctca gaagccctaa ctgtggctgc 32220

cgccgcacct ctaatggtcg cgggcaacac actcaccatg caatcacagg ccccgctaac 32280 cgtgcacgac tccaaactta gcattgccac ccaaggaccc ctcacagtgt cagaaggaaa 32340

gctagccctg caaacatcag gccccctcac caccaccgat agcagtaccc ttactatcac 32400

tgcctcaccc cctctaacta ctgccactgg tagcttgggc attgacttga aagagcccat 32460

ttatacacaa aatggaaaac taggactaaa gtacggggct cctttgcatg taacagacga 32520

cctaaacact ttgaccgtag caactggtcc aggtgtgact attaataata cttccttgca 32580 aactaaagtt actggagcct tgggttttga ttcacaaggc aatatgcaac ttaatgtagc 32640

aggaggacta aggattgatt ctcaaaacag acgccttata cttgatgtta gttatccgtt 32700

tgatgctcaa aaccaactaa atctaagact aggacagggc cctcttttta taaactcagc 32760 ccacaacttg gatattaact acaacaaagg cctttacttg tttacagctt caaacaattc 32820

caaaaagctt gaggttaacc taagcactgc caaggggttg atgtttgacg ctacagccat 32880 agccattaat gcaggagatg ggcttgaatt tggttcacct aatgcaccaa acacaaatcc 32940 cctcaaaaca aaaattggcc atggcctaga atttgattca aacaaggcta tggttcctaa 33000

actaggaact ggccttagtt ttgacagcac aggtgccatt acagtaggaa acaaaaataa 33060 tgataagcta actttgtgga ccacaccagc tccatctcct aactgtagac taaatgcaga 33120 gaaagatgct aaactcactt tggtcttaac aaaatgtggc agtcaaatac ttgctacagt 33180

ttcagttttg gctgttaaag gcagtttggc tccaatatct ggaacagttc aaagtgctca 33240 tcttattata agatttgacg aaaatggagt gctactaaac aattccttcc tggacccaga 33300

atattggaac tttagaaatg gagatcttac tgaaggcaca gcctatacaa acgctgttgg 33360 atttatgcct aacctatcag cttatccaaa atctcacggt aaaactgcca aaagtaacat 33420 tgtcagtcaa gtttacttaa acggagacaa aactaaacct gtaacactaa ccattacact 33480

aaacggtaca caggaaacag gagacacaac tccaagtgca tactctatgt cattttcatg 33540 Page 35

Sequence_Listing.txt ggactggtct ggccacaact acattaatga aatatttgcc acatcctctt acactttttc 33600

atacattgcc caagaataaa gaatcgtttg tgttatgttt caacgtgttt atttttcaat 33660 tgcagaaaat ttcaagtcat ttttcattca gtagtatagc cccaccacca catagcttat 33720

acagatcacc gtacctcaac tttgtataat aaagttgtaa tcaaactcac agaaccctag 33780 tattcaacct gccacctccc tcccaacaca cagagtacac agtcctttct ccccggctgg 33840 ccttaaaaag catcatatca tgggtaacag acatattctt aggtgttata ttccacacgg 33900

tttcctgtcg agccaaacgc tcatcagtga tattaataaa ctccccgggc agctcactta 33960 agttcatgtc gctgtccagc tgctgagcca caggctgctg tccaacttgc ggttgcttaa 34020 cgggcggcga aggagaagtc cacgcctaca tgggggtaga gtcataatcg tgcatcagga 34080

tagggcggtg gtgctgcagc agcgcgcgaa taaactgctg ccgccgccgc tccgtcctgc 34140 aggaatacaa catggcagtg gtctcctcag cgatgattcg caccgcccgc agcataaggc 34200 gccttgtcct ccgggcacag cagcgcaccc tgatctcact taaatcagca cagtaactgc 34260

agcacagcac cacaatattg ttcaaaatcc cacagtgcaa ggcgctgtat ccaaagctca 34320 tggcggggac cacagaaccc acgtggccat cataccacaa gcgcaggtag attaagtggc 34380

gacccctcat aaacacgctg gacataaaca ttacctcttt tggcatgttg taattcacca 34440

cctcccggta ccatataaac ctctgattaa acatggcgcc atccaccacc atcctaaacc 34500

agctggccaa aacctgcccg ccggctatac actgcaggga accgggactg gaacaatgac 34560

agtggagagc ccaggactcg taaccatgga tcatcatgct cgtcatgata tcaatgttgg 34620 cacaacacag gcacacgtgc atacacttcc tcaggattac aagctcctcc cgcgttagaa 34680

ccatatccca gggaacaacc cattcctgaa tcagcgtaaa tcccacactg cagggaagac 34740

ctcgcacgta actcacgttg tgcattgtca aagtgttaca ttcgggcagc agcggatgat 34800 cctccagtat ggtagcgcgg gtttctgtct caaaaggagg tagacgatcc ctactgtacg 34860

gagtgcgccg agacaaccga gatcgtgttg gtcgtagtgt catgccaaat ggaacgccgg 34920 acgtagtcat atttcctgaa gcaaaaccag gtgcgggcgt gacaaacaga tctgcgtctc 34980 cggtctcgcc gcttagatcg ctctgtgtag tagttgtagt atatccactc tctcaaagca 35040

tccaggcgcc ccctggcttc gggttctatg taaactcctt catgcgccgc tgccctgata 35100 acatccacca ccgcagaata agccacaccc agccaaccta cacattcgtt ctgcgagtca 35160 cacacgggag gagcgggaag agctggaaga accatgtttt tttttttatt ccaaaagatt 35220

atccaaaacc tcaaaatgaa gatctattaa gtgaacgcgc tcccctccgg tggcgtggtc 35280 aaactctaca gccaaagaac agataatggc atttgtaaga tgttgcacaa tggcttccaa 35340

aaggcaaacg gccctcacgt ccaagtggac gtaaaggcta aacccttcag ggtgaatctc 35400 ctctataaac attccagcac cttcaaccat gcccaaataa ttctcatctc gccaccttct 35460 caatatatct ctaagcaaat cccgaatatt aagtccggcc attgtaaaaa tctgctccag 35520

agcgccctcc accttcagcc tcaagcagcg aatcatgatt gcaaaaattc aggttcctca 35580 Page 36

Sequence_Listing.txt cagacctgta taagattcaa aagcggaaca ttaacaaaaa taccgcgatc ccgtaggtcc 35640

cttcgcaggg ccagctgaac ataatcgtgc aggtctgcac ggaccagcgc ggccacttcc 35700 ccgccaggaa ccatgacaaa agaacccaca ctgattatga cacgcatact cggagctatg 35760

ctaaccagcg tagccccgat gtaagcttgt tgcatgggcg gcgatataaa atgcaaggtg 35820 ctgctcaaaa aatcaggcaa agcctcgcgc aaaaaagaaa gcacatcgta gtcatgctca 35880 tgcagataaa ggcaggtaag ctccggaacc accacagaaa aagacaccat ttttctctca 35940

aacatgtctg cgggtttctg cataaacaca aaataaaata acaaaaaaac atttaaacat 36000 tagaagcctg tcttacaaca ggaaaaacaa cccttataag cataagacgg actacggcca 36060 tgccggcgtg accgtaaaaa aactggtcac cgtgattaaa aagcaccacc gacagctcct 36120

cggtcatgtc cggagtcata atgtaagact cggtaaacac atcaggttga ttcacatcgg 36180 tcagtgctaa aaagcgaccg aaatagcccg ggggaataca tacccgcagg cgtagagaca 36240 acattacagc ccccatagga ggtataacaa aattaatagg agagaaaaac acataaacac 36300

ctgaaaaacc ctcctgccta ggcaaaatag caccctcccg ctccagaaca acatacagcg 36360 cttccacagc ggcagccata acagtcagcc ttaccagtaa aaaagaaaac ctattaaaaa 36420

aacaccactc gacacggcac cagctcaatc agtcacagtg taaaaaaggg ccaagtgcag 36480

agcgagtata tataggacta aaaaatgacg taacggttaa agtccacaaa aaacacccag 36540

aaaaccgcac gcgaacctac gcccagaaac gaaagccaaa aaacccacaa cttcctcaaa 36600

tcgtcacttc cgttttccca cgttacgtca cttcccattt taagaaaact acaattccca 36660 acacatacaa gttactccgc cctaaaacct acgtcacccg ccccgttccc acgccccgcg 36720

ccacgtcaca aactccaccc cctcattatc atattggctt caatccaaaa taaggtatat 36780

tattgatgat g 36791

<210> 3 <211> 36791 <212> DNA <213> Artificial Sequence <220> <223> Synthetic adenovirus genome E1B-55k-P2A-YPet <400> 3 catcatcaat aatatacctt attttggatt gaagccaata tgataatgag ggggtggagt 60 ttgtgacgtg gcgcggggcg tgggaacggg gcgggtgacg tagtagtgtg gcggaagtgt 120

gatgttgcaa gtgtggcgga acacatgtaa gcgacggatg tggcaaaagt gacgtttttg 180 gtgtgcgccg gtgtacacag gaagtgacaa ttttcgcgcg gttttaggcg gatgttgtag 240

taaatttggg cgtaaccgag taagatttgg ccattttcgc gggaaaactg aataagagga 300 agtgaaatct gaataatttt gtgttactca tagcgcgtaa tatttgtcta gggccgcggg 360 gactttgacc gtttacgtgg agactcgccc aggtgttttt ctcaggtgtt ttccgcgttc 420

cgggtcaaag ttggcgtttt attattatag tcagctgacg tgtagtgtat ttatacccgg 480 Page 37

Sequence_Listing.txt tgagttcctc aagaggccac tcttgagtgc cagcgagtag agttttctcc tccgagccgc 540

tccgacaccg ggactgaaaa tgagacatat tatctgccac ggaggtgtta ttaccgaaga 600 aatggccgcc agtcttttgg accagctgat cgaagaggta ctggctgata atcttccacc 660

tcctagccat tttgaaccac ctacccttca cgaactgtat gatttagacg tgacggcccc 720 cgaagatccc aacgaggagg cggtttcgca gatttttccc gactctgtaa tgttggcggt 780 gcaggaaggg attgacttac tcacttttcc gccggcgccc ggttctccgg agccgcctca 840

cctttcccgg cagcccgagc agccggagca gagagccttg ggtccggttt ctatgccaaa 900 ccttgtaccg gaggtgatcg atcttacctg ccacgaggct ggctttccac ccagtgacga 960 cgaggatgaa gagggtgagg agtttgtgtt agattatgtg gagcaccccg ggcacggttg 1020

caggtcttgt cattatcacc ggaggaatac gggggaccca gatattatgt gttcgctttg 1080 ctatatgagg acctgtggca tgtttgtcta cagtaagtga aaattatggg cagtgggtga 1140 tagagtggtg ggtttggtgt ggtaattttt tttttaattt ttacagtttt gtggtttaaa 1200

gaattttgta ttgtgatttt tttaaaaggt cctgtgtctg aacctgagcc tgagcccgag 1260 ccagaaccgg agcctgcaag acctacccgc cgtcctaaaa tggcgcctgc tatcctgaga 1320

cgcccgacat cacctgtgtc tagagaatgc aatagtagta cggatagctg tgactccggt 1380

ccttctaaca cacctcctga gatacacccg gtggtcccgc tgtgccccat taaaccagtt 1440

gccgtgagag ttggtgggcg tcgccaggct gtggaatgta tcgaggactt gcttaacgag 1500

cctgggcaac ctttggactt gagctgtaaa cgccccaggc cataaggtgt aaacctgtga 1560 ttgcgtgtgt ggttaacgcc tttgtttgct gaatgagttg atgtaagttt aataaagggt 1620

gagataatgt ttaacttgca tggcgtgtta aatggggcgg ggcttaaagg gtatataatg 1680

cgccgtgggc taatcttggt tacatctgac ctcatggagg cttgggagtg tttggaagat 1740 ttttctgctg tgcgtaactt gctggaacag agctctaaca gtacctcttg gttttggagg 1800

tttctgtggg gctcatccca ggcaaagtta gtctgcagaa ttaaggagga ttacaagtgg 1860 gaatttgaag agcttttgaa atcctgtggt gagctgtttg attctttgaa tctgggtcac 1920 caggcgcttt tccaagagaa ggtcatcaag actttggatt tttccacacc ggggcgcgct 1980

gcggctgctg ttgctttttt gagttttata aaggataaat ggagcgaaga aacccatctg 2040 agcggggggt acctgctgga ttttctggcc atgcatctgt ggagagcggt tgtgagacac 2100 aagaatcgcc tgctactgtt gtcttccgtc cgcccggcga taataccgac ggaggagcag 2160

cagcagcagc aggaggaagc caggcggcgg cggcaggagc agagcccatg gaacccgaga 2220 gccggcctgg accctcggga atgaatgttg tacaggtggc tgaactgtat ccagaactga 2280

gacgcatttt gacaattaca gaggatgggc aggggctaaa gggggtaaag agggagcggg 2340 gggcttgtga ggctacagag gaggctagga atctagcttt tagcttaatg accagacacc 2400 gtcctgagtg tattactttt caacagatca aggataattg cgctaatgag cttgatctgc 2460

tggcgcagaa gtattccata gagcagctga ccacttactg gctgcagcca ggggatgatt 2520 Page 38

Sequence_Listing.txt ttgaggaggc tattagggta tatgcaaagg tggcacttag gccagattgc aagtacaaga 2580

tcagcaaact tgtaaatatc aggaattgtt gctacatttc tgggaacggg gccgaggtgg 2640 agatagatac ggaggatagg gtggccttta gatgtagcat gataaatatg tggccggggg 2700

tgcttggcat ggacggggtg gttattatga atgtaaggtt tactggcccc aattttagcg 2760 gtacggtttt cctggccaat accaacctta tcctacacgg tgtaagcttc tatgggttta 2820 acaatacctg tgtggaagcc tggaccgatg taagggttcg gggctgtgcc ttttactgct 2880

gctggaaggg ggtggtgtgt cgccccaaaa gcagggcttc aattaagaaa tgcctctttg 2940 aaaggtgtac cttgggtatc ctgtctgagg gtaactccag ggtgcgccac aatgtggcct 3000 ccgactgtgg ttgcttcatg ctagtgaaaa gcgtggctgt gattaagcat aacatggtat 3060

gtggcaactg cgaggacagg gcctctcaga tgctgacctg ctcggacggc aactgtcacc 3120 tgctgaagac cattcacgta gccagccact ctcgcaaggc ctggccagtg tttgagcata 3180 acatactgac ccgctgttcc ttgcatttgg gtaacaggag gggggtgttc ctaccttacc 3240

aatgcaattt gagtcacact aagatattgc ttgagcccga gagcatgtcc aaggtgaacc 3300 tgaacggggt gtttgacatg accatgaaga tctggaaggt gctgaggtac gatgagaccc 3360

gcaccaggtg cagaccctgc gagtgtggcg gtaaacatat taggaaccag cctgtgatgc 3420

tggatgtgac cgaggagctg aggcccgatc acttggtgct ggcctgcacc cgcgctgagt 3480

ttggctctag cgatgaagat acagatggaa gcggagctac taacttcagc ctgctgaagc 3540

aggctggtga cgtcgaggag aatcctggcc caatggtgag caaaggcgaa gagctgttca 3600 ccggcgtggt gcccatcctg gtggagctgg acggcgacgt gaacggccac aagttcagcg 3660

tgagcggcga gggcgagggc gacgccacct acggcaagct gaccctgaag ctgctgtgca 3720

ccaccggcaa gctgcccgtg ccctggccca ccctggtgac caccctgggc tacggcgtgc 3780 agtgcttcgc ccggtacccc gaccacatga agcagcacga cttcttcaag agcgccatgc 3840

ccgagggcta cgtgcaggag cggaccatct tcttcaagga cgacggcaac tacaagaccc 3900 gggccgaggt gaagttcgag ggcgacaccc tggtgaaccg gatcgagctg aagggcatcg 3960 acttcaagga ggacggcaac atcctgggcc acaagctgga gtacaactac aacagccaca 4020

acgtgtacat caccgccgac aagcagaaga acggcatcaa ggccaacttc aagatccggc 4080 acaacatcga ggacggcggc gtgcagctgg ccgaccacta ccagcagaac acccccatcg 4140 gcgacggccc cgtgctgctg cccgacaacc actacctgag ctaccagagc gccctgttca 4200

aggaccccaa cgagaagcgg gaccacatgg tgctgctgga gttcctgacc gccgccggca 4260 tcaccgaggg catgaacgag ctctataagt gaggtactga aatgtgtggg cgtggcttaa 4320

gggtgggaaa gaatatataa ggtgggggtc ttatgtagtt ttgtatctgt tttgcagcag 4380 ccgccgccgc ccaacttttc tatacaaagt tgtaatgagc accaactcgt ttgatggaag 4440 cattgtgagc tcatatttga caacgcgcat gcccccatgg gccggggtgc gtcagaatgt 4500

gatgggctcc agcattgatg gtcgccccgt cctgcccgca aactctacta ccttgaccta 4560 Page 39

Sequence_Listing.txt cgagaccgtg tctggaacgc cgttggagac tgcagcctcc gccgccgctt cagccgctgc 4620

agccaccgcc cgcgggattg tgactgactt tgctttcctg agcccgcttg caagcagtgc 4680 agcttcccgt tcatccgccc gcgatgacaa gttgacggct cttttggcac aattggattc 4740

tttgacccgg gaacttaatg tcgtttctca gcagctgttg gatctgcgcc agcaggtttc 4800 tgccctgaag gcttcctccc ctcccaatgc ggtttaaaac ataaataaaa aaccagactc 4860 tgtttggatt tggatcaagc ataagtgtct tgctgtcttt atttaggggt tttgcgcgcg 4920

cggtaggccc gggaccagcg gtctcggtcg ttgagggtcc tgtgtatttt ttccaggacg 4980 tggtaaaggt gactctggat gttcagatac atgggcataa gcccgtctct ggggtggagg 5040 tagcaccact gcagagcttc atgctgcggg gtggtgttgt agatgatcca gtcgtagcag 5100

gagcgctggg cgtggtgcct aaaaatgtct ttcagtagca agctgattgc caggggcagg 5160 cccttggtgt aagtgtttac aaagcggtta agctgggatg ggtgcatacg tggggatatg 5220 agatgcatct tggactgtat ttttaggttg gctatgttcc cagccatatc cctccgggga 5280

ttcatgttgt gcagaaccac cagcacagtg tatccggtgc acttgggaaa tttgtcatgt 5340 agcttagaag gaaatgcgtg gaagaacttg gagacgccct tgtgacctcc aagattttcc 5400

atgcattcgt ccataatgat ggcaatgggc ccacgggcgg cggcctgggc gaagatattt 5460

ctgggatcac taacgtcata gttgtgttcc aggatgagat cgtcataggc catttttaca 5520

aagcgcgggc ggagggtgcc agactgcggt ataatggttc catccggccc aggggcgtag 5580

ttaccctcac agatttgcat ttcccacgct ttgagttcag atggggggat catgtctacc 5640 tgcggggcga tgaagaaaac ggtttccggg gtaggggaga tcagctggga agaaagcagg 5700

ttcctgagca gctgcgactt accgcagccg gtgggcccgt aaatcacacc tattaccggg 5760

tgcaactggt agttaagaga gctgcagctg ccgtcatccc tgagcagggg ggccacttcg 5820 ttaagcatgt ccctgactcg catgttttcc ctgaccaaat ccgccagaag gcgctcgccg 5880

cccagcgata gcagttcttg caaggaagca aagtttttca acggtttgag accgtccgcc 5940 gtaggcatgc ttttgagcgt ttgaccaagc agttccaggc ggtcccacag ctcggtcacc 6000 tgctctacgg catctcgatc cagcatatct cctcgtttcg cgggttgggg cggctttcgc 6060

tgtacggcag tagtcggtgc tcgtccagac gggccagggt catgtctttc cacgggcgca 6120 gggtcctcgt cagcgtagtc tgggtcacgg tgaaggggtg cgctccgggc tgcgcgctgg 6180 ccagggtgcg cttgaggctg gtcctgctgg tgctgaagcg ctgccggtct tcgccctgcg 6240

cgtcggccag gtagcatttg accatggtgt catagtccag cccctccgcg gcgtggccct 6300 tggcgcgcag cttgcccttg gaggaggcgc cgcacgaggg gcagtgcaga cttttgaggg 6360

cgtagagctt gggcgcgaga aataccgatt ccggggagta ggcatccgcg ccgcaggccc 6420 cgcagacggt ctcgcattcc acgagccagg tgagctctgg ccgttcgggg tcaaaaacca 6480 ggtttccccc atgctttttg atgcgtttct tacctctggt ttccatgagc cggtgtccac 6540

gctcggtgac gaaaaggctg tccgtgtccc cgtatacaga cttgagaggc ctgtcctcga 6600 Page 40

Sequence_Listing.txt gcggtgttcc gcggtcctcc tcgtatagaa actcggacca ctctgagaca aaggctcgcg 6660

tccaggccag cacgaaggag gctaagtggg aggggtagcg gtcgttgtcc actagggggt 6720 ccactcgctc cagggtgtga agacacatgt cgccctcttc ggcatcaagg aaggtgattg 6780

gtttgtaggt gtaggccacg tgaccgggtg ttcctgaagg ggggctataa aagggggtgg 6840 gggcgcgttc gtcctcactc tcttccgcat cgctgtctgc gagggccagc tgttggggtg 6900 agtactccct ctgaaaagcg ggcatgactt ctgcgctaag attgtcagtt tccaaaaacg 6960

aggaggattt gatattcacc tggcccgcgg tgatgccttt gagggtggcc gcatccatct 7020 ggtcagaaaa gacaatcttt ttgttgtcaa gcttggtggc aaacgacccg tagagggcgt 7080 tggacagcaa cttggcgatg gagcgcaggg tttggttttt gtcgcgatcg gcgcgctcct 7140

tggccgcgat gtttagctgc acgtattcgc gcgcaacgca ccgccattcg ggaaagacgg 7200 tggtgcgctc gtcgggcacc aggtgcacgc gccaaccgcg gttgtgcagg gtgacaaggt 7260 caacgctggt ggctacctct ccgcgtaggc gctcgttggt ccagcagagg cggccgccct 7320

tgcgcgagca gaatggcggt agggggtcta gctgcgtctc gtccgggggg tctgcgtcca 7380 cggtaaagac cccgggcagc aggcgcgcgt cgaagtagtc tatcttgcat ccttgcaagt 7440

ctagcgcctg ctgccatgcg cgggcggcaa gcgcgcgctc gtatgggttg agtgggggac 7500

cccatggcat ggggtgggtg agcgcggagg cgtacatgcc gcaaatgtcg taaacgtaga 7560

ggggctctct gagtattcca agatatgtag ggtagcatct tccaccgcgg atgctggcgc 7620

gcacgtaatc gtatagttcg tgcgagggag cgaggaggtc gggaccgagg ttgctacggg 7680 cgggctgctc tgctcggaag actatctgcc tgaagatggc atgtgagttg gatgatatgg 7740

ttggacgctg gaagacgttg aagctggcgt ctgtgagacc taccgcgtca cgcacgaagg 7800

aggcgtagga gtcgcgcagc ttgttgacca gctcggcggt gacctgcacg tctagggcgc 7860 agtagtccag ggtttccttg atgatgtcat acttatcctg tccctttttt ttccacagct 7920

cgcggttgag gacaaactct tcgcggtctt tccagtactc ttggatcgga aacccgtcgg 7980 cctccgaacg gtaagagcct agcatgtaga actggttgac ggcctggtag gcgcagcatc 8040 ccttttctac gggtagcgcg tatgcctgcg cggccttccg gagcgaggtg tgggtgagcg 8100

caaaggtgtc cctgaccatg actttgaggt actggtattt gaagtcagtg tcgtcgcatc 8160 cgccctgctc ccagagcaaa aagtccgtgc gctttttgga acgcggattt ggcagggcga 8220 aggtgacatc gttgaagagt atctttcccg cgcgaggcat aaagttgcgt gtgatgcgga 8280

agggtcccgg cacctcggaa cggttgttaa ttacctgggc ggcgagcacg atctcgtcaa 8340 agccgttgat gttgtggccc acaatgtaaa gttccaagaa gcgcgggatg cccttgatgg 8400

aaggcaattt tttaagttcc tcgtaggtga gctcttcagg ggagctgagc ccgtgctctg 8460 aaagggccca gtctgcaaga tgagggttgg aagcgacgaa tgagctccac aggtcacggg 8520 ccattagcat ttgcaggtgg tcgcgaaagg tcctaaactg gcgacctatg gccatttttt 8580

ctggggtgat gcagtagaag gtaagcgggt cttgttccca gcggtcccat ccaaggttcg 8640 Page 41

Sequence_Listing.txt cggctaggtc tcgcgcggca gtcactagag gctcatctcc gccgaacttc atgaccagca 8700

tgaagggcac gagctgcttc ccaaaggccc ccatccaagt ataggtctct acatcgtagg 8760 tgacaaagag acgctcggtg cgaggatgcg agccgatcgg gaagaactgg atctcccgcc 8820

accaattgga ggagtggcta ttgatgtggt gaaagtagaa gtccctgcga cgggccgaac 8880 actcgtgctg gcttttgtaa aaacgtgcgc agtactggca gcggtgcacg ggctgtacat 8940 cctgcacgag gttgacctga cgaccgcgca caaggaagca gagtgggaat ttgagcccct 9000

cgcctggcgg gtttggctgg tggtcttcta cttcggctgc ttgtccttga ccgtctggct 9060 gctcgagggg agttacggtg gatcggacca ccacgccgcg cgagcccaaa gtccagatgt 9120 ccgcgcgcgg cggtcggagc ttgatgacaa catcgcgcag atgggagctg tccatggtct 9180

ggagctcccg cggcgtcagg tcaggcggga gctcctgcag gtttacctcg catagacggg 9240 tcagggcgcg ggctagatcc aggtgatacc taatttccag gggctggttg gtggcggcgt 9300 cgatggcttg caagaggccg catccccgcg gcgcgactac ggtaccgcgc ggcgggcggt 9360

gggccgcggg ggtgtccttg gatgatgcat ctaaaagcgg tgacgcgggc gagcccccgg 9420 aggtaggggg ggctccggac ccgccgggag agggggcagg ggcacgtcgg cgccgcgcgc 9480

gggcaggagc tggtgctgcg cgcgtaggtt gctggcgaac gcgacgacgc ggcggttgat 9540

ctcctgaatc tggcgcctct gcgtgaagac gacgggcccg gtgagcttga gcctgaaaga 9600

gagttcgaca gaatcaattt cggtgtcgtt gacggcggcc tggcgcaaaa tctcctgcac 9660

gtctcctgag ttgtcttgat aggcgatctc ggccatgaac tgctcgatct cttcctcctg 9720 gagatctccg cgtccggctc gctccacggt ggcggcgagg tcgttggaaa tgcgggccat 9780

gagctgcgag aaggcgttga ggcctccctc gttccagacg cggctgtaga ccacgccccc 9840

ttcggcatcg cgggcgcgca tgaccacctg cgcgagattg agctccacgt gccgggcgaa 9900 gacggcgtag tttcgcaggc gctgaaagag gtagttgagg gtggtggcgg tgtgttctgc 9960

cacgaagaag tacataaccc agcgtcgcaa cgtggattcg ttgatatccc ccaaggcctc 10020 aaggcgctcc atggcctcgt agaagtccac ggcgaagttg aaaaactggg agttgcgcgc 10080 cgacacggtt aactcctcct ccagaagacg gatgagctcg gcgacagtgt cgcgcacctc 10140

gcgctcaaag gctacagggg cctcttcttc ttcttcaatc tcctcttcca taagggcctc 10200 cccttcttct tcttctggcg gcggtggggg aggggggaca cggcggcgac gacggcgcac 10260 cgggaggcgg tcgacaaagc gctcgatcat ctccccgcgg cgacggcgca tggtctcggt 10320

gacggcgcgg ccgttctcgc gggggcgcag ttggaagacg ccgcccgtca tgtcccggtt 10380 atgggttggc ggggggctgc catgcggcag ggatacggcg ctaacgatgc atctcaacaa 10440

ttgttgtgta ggtactccgc cgccgaggga cctgagcgag tccgcatcga ccggatcgga 10500 aaacctctcg agaaaggcgt ctaaccagtc acagtcgcaa ggtaggctga gcaccgtggc 10560 gggcggcagc gggcggcggt cggggttgtt tctggcggag gtgctgctga tgatgtaatt 10620

aaagtaggcg gtcttgagac ggcggatggt cgacagaagc accatgtcct tgggtccggc 10680 Page 42

Sequence_Listing.txt ctgctgaatg cgcaggcggt cggccatgcc ccaggcttcg ttttgacatc ggcgcaggtc 10740

tttgtagtag tcttgcatga gcctttctac cggcacttct tcttctcctt cctcttgtcc 10800 tgcatctctt gcatctatcg ctgcggcggc ggcggagttt ggccgtaggt ggcgccctct 10860

tcctcccatg cgtgtgaccc cgaagcccct catcggctga agcagggcta ggtcggcgac 10920 aacgcgctcg gctaatatgg cctgctgcac ctgcgtgagg gtagactgga agtcatccat 10980 gtccacaaag cggtggtatg cgcccgtgtt gatggtgtaa gtgcagttgg ccataacgga 11040

ccagttaacg gtctggtgac ccggctgcga gagctcggtg tacctgagac gcgagtaagc 11100 cctcgagtca aatacgtagt cgttgcaagt ccgcaccagg tactggtatc ccaccaaaaa 11160 gtgcggcggc ggctggcggt agaggggcca gcgtagggtg gccggggctc cgggggcgag 11220

atcttccaac ataaggcgat gatatccgta gatgtacctg gacatccagg tgatgccggc 11280 ggcggtggtg gaggcgcgcg gaaagtcgcg gacgcggttc cagatgttgc gcagcggcaa 11340 aaagtgctcc atggtcggga cgctctggcc ggtcaggcgc gcgcaatcgt tgacgctcta 11400

gaccgtgcaa aaggagagcc tgtaagcggg cactcttccg tggtctggtg gataaattcg 11460 caagggtatc atggcggacg accggggttc gagccccgta tccggccgtc cgccgtgatc 11520

catgcggtta ccgcccgcgt gtcgaaccca ggtgtgcgac gtcagacaac gggggagtgc 11580

tccttttggc ttccttccag gcgcggcggc tgctgcgcta gcttttttgg ccactggccg 11640

cgcgcagcgt aagcggttag gctggaaagc gaaagcatta agtggctcgc tccctgtagc 11700

cggagggtta ttttccaagg gttgagtcgc gggacccccg gttcgagtct cggaccggcc 11760 ggactgcggc gaacgggggt ttgcctcccc gtcatgcaag accccgcttg caaattcctc 11820

cggaaacagg gacgagcccc ttttttgctt ttcccagatg catccggtgc tgcggcagat 11880

gcgcccccct cctcagcagc ggcaagagca agagcagcgg cagacatgca gggcaccctc 11940 ccctcctcct accgcgtcag gaggggcgac atccgcggtt gacgcggcag cagatggtga 12000

ttacgaaccc ccgcggcgcc gggcccggca ctacctggac ttggaggagg gcgagggcct 12060 ggcgcggcta ggagcgccct ctcctgagcg gtacccaagg gtgcagctga agcgtgatac 12120 gcgtgaggcg tacgtgccgc ggcagaacct gtttcgcgac cgcgagggag aggagcccga 12180

ggagatgcgg gatcgaaagt tccacgcagg gcgcgagctg cggcatggcc tgaatcgcga 12240 gcggttgctg cgcgaggagg actttgagcc cgacgcgcga accgggatta gtcccgcgcg 12300 cgcacacgtg gcggccgccg acctggtaac cgcatacgag cagacggtga accaggagat 12360

taactttcaa aaaagcttta acaaccacgt gcgtacgctt gtggcgcgcg aggaggtggc 12420 tataggactg atgcatctgt gggactttgt aagcgcgctg gagcaaaacc caaatagcaa 12480

gccgctcatg gcgcagctgt tccttatagt gcagcacagc agggacaacg aggcattcag 12540 ggatgcgctg ctaaacatag tagagcccga gggccgctgg ctgctcgatt tgataaacat 12600 cctgcagagc atagtggtgc aggagcgcag cttgagcctg gctgacaagg tggccgccat 12660

caactattcc atgcttagcc tgggcaagtt ttacgcccgc aagatatacc atacccctta 12720 Page 43

Sequence_Listing.txt cgttcccata gacaaggagg taaagatcga ggggttctac atgcgcatgg cgctgaaggt 12780

gcttaccttg agcgacgacc tgggcgttta tcgcaacgag cgcatccaca aggccgtgag 12840 cgtgagccgg cggcgcgagc tcagcgaccg cgagctgatg cacagcctgc aaagggccct 12900

ggctggcacg ggcagcggcg atagagaggc cgagtcctac tttgacgcgg gcgctgacct 12960 gcgctgggcc ccaagccgac gcgccctgga ggcagctggg gccggacctg ggctggcggt 13020 ggcacccgcg cgcgctggca acgtcggcgg cgtggaggaa tatgacgagg acgatgagta 13080

cgagccagag gacggcgagt actaagcggt gatgtttctg atcagatgat gcaagacgca 13140 acggacccgg cggtgcgggc ggcgctgcag agccagccgt ccggccttaa ctccacggac 13200 gactggcgcc aggtcatgga ccgcatcatg tcgctgactg cgcgcaatcc tgacgcgttc 13260

cggcagcagc cgcaggccaa ccggctctcc gcaattctgg aagcggtggt cccggcgcgc 13320 gcaaacccca cgcacgagaa ggtgctggcg atcgtaaacg cgctggccga aaacagggcc 13380 atccggcccg acgaggccgg cctggtctac gacgcgctgc ttcagcgcgt ggctcgttac 13440

aacagcggca acgtgcagac caacctggac cggctggtgg gggatgtgcg cgaggccgtg 13500 gcgcagcgtg agcgcgcgca gcagcagggc aacctgggct ccatggttgc actaaacgcc 13560

ttcctgagta cacagcccgc caacgtgccg cggggacagg aggactacac caactttgtg 13620

agcgcactgc ggctaatggt gactgagaca ccgcaaagtg aggtgtacca gtctgggcca 13680

gactattttt tccagaccag tagacaaggc ctgcagaccg taaacctgag ccaggctttc 13740

aaaaacttgc aggggctgtg gggggtgcgg gctcccacag gcgaccgcgc gaccgtgtct 13800 agcttgctga cgcccaactc gcgcctgttg ctgctgctaa tagcgccctt cacggacagt 13860

ggcagcgtgt cccgggacac atacctaggt cacttgctga cactgtaccg cgaggccata 13920

ggtcaggcgc atgtggacga gcatactttc caggagatta caagtgtcag ccgcgcgctg 13980 gggcaggagg acacgggcag cctggaggca accctaaact acctgctgac caaccggcgg 14040

cagaagatcc cctcgttgca cagtttaaac agcgaggagg agcgcatttt gcgctacgtg 14100 cagcagagcg tgagccttaa cctgatgcgc gacggggtaa cgcccagcgt ggcgctggac 14160 atgaccgcgc gcaacatgga accgggcatg tatgcctcaa accggccgtt tatcaaccgc 14220

ctaatggact acttgcatcg cgcggccgcc gtgaaccccg agtatttcac caatgccatc 14280 ttgaacccgc actggctacc gccccctggt ttctacaccg ggggattcga ggtgcccgag 14340 ggtaacgatg gattcctctg ggacgacata gacgacagcg tgttttcccc gcaaccgcag 14400

accctgctag agttgcaaca gcgcgagcag gcagaggcgg cgctgcgaaa ggaaagcttc 14460 cgcaggccaa gcagcttgtc cgatctaggc gctgcggccc cgcggtcaga tgctagtagc 14520

ccatttccaa gcttgatagg gtctcttacc agcactcgca ccacccgccc gcgcctgctg 14580 ggcgaggagg agtacctaaa caactcgctg ctgcagccgc agcgcgaaaa aaacctgcct 14640 ccggcatttc ccaacaacgg gatagagagc ctagtggaca agatgagtag atggaagacg 14700

tacgcgcagg agcacaggga cgtgccaggc ccgcgcccgc ccacccgtcg tcaaaggcac 14760 Page 44

Sequence_Listing.txt gaccgtcagc ggggtctggt gtgggaggac gatgactcgg cagacgacag cagcgtcctg 14820

gatttgggag ggagtggcaa cccgtttgcg caccttcgcc ccaggctggg gagaatgttt 14880 taaaaaaaaa aaagcatgat gcaaaataaa aaactcacca aggccatggc accgagcgtt 14940

ggttttcttg tattcccctt agtatgcggc gcgcggcgat gtatgaggaa ggtcctcctc 15000 cctcctacga gagtgtggtg agcgcggcgc cagtggcggc ggcgctgggt tctcccttcg 15060 atgctcccct ggacccgccg tttgtgcctc cgcggtacct gcggcctacc ggggggagaa 15120

acagcatccg ttactctgag ttggcacccc tattcgacac cacccgtgtg tacctggtgg 15180 acaacaagtc aacggatgtg gcatccctga actaccagaa cgaccacagc aactttctga 15240 ccacggtcat tcaaaacaat gactacagcc cgggggaggc aagcacacag accatcaatc 15300

ttgacgaccg gtcgcactgg ggcggcgacc tgaaaaccat cctgcatacc aacatgccaa 15360 atgtgaacga gttcatgttt accaataagt ttaaggcgcg ggtgatggtg tcgcgcttgc 15420 ctactaagga caatcaggtg gagctgaaat acgagtgggt ggagttcacg ctgcccgagg 15480

gcaactactc cgagaccatg accatagacc ttatgaacaa cgcgatcgtg gagcactact 15540 tgaaagtggg cagacagaac ggggttctgg aaagcgacat cggggtaaag tttgacaccc 15600

gcaacttcag actggggttt gaccccgtca ctggtcttgt catgcctggg gtatatacaa 15660

acgaagcctt ccatccagac atcattttgc tgccaggatg cggggtggac ttcacccaca 15720

gccgcctgag caacttgttg ggcatccgca agcggcaacc cttccaggag ggctttagga 15780

tcacctacga tgatctggag ggtggtaaca ttcccgcact gttggatgtg gacgcctacc 15840 aggcgagctt gaaagatgac accgaacagg gcgggggtgg cgcaggcggc agcaacagca 15900

gtggcagcgg cgcggaagag aactccaacg cggcagccgc ggcaatgcag ccggtggagg 15960

acatgaacga tcatgccatt cgcggcgaca cctttgccac acgggctgag gagaagcgcg 16020 ctgaggccga agcagcggcc gaagctgccg cccccgctgc gcaacccgag gtcgagaagc 16080

ctcagaagaa accggtgatc aaacccctga cagaggacag caagaaacgc agttacaacc 16140 taataagcaa tgacagcacc ttcacccagt accgcagctg gtaccttgca tacaactacg 16200 gcgaccctca gaccggaatc cgctcatgga ccctgctttg cactcctgac gtaacctgcg 16260

gctcggagca ggtctactgg tcgttgccag acatgatgca agaccccgtg accttccgct 16320 ccacgcgcca gatcagcaac tttccggtgg tgggcgccga gctgttgccc gtgcactcca 16380 agagcttcta caacgaccag gccgtctact cccaactcat ccgccagttt acctctctga 16440

cccacgtgtt caatcgcttt cccgagaacc agattttggc gcgcccgcca gcccccacca 16500 tcaccaccgt cagtgaaaac gttcctgctc tcacagatca cgggacgcta ccgctgcgca 16560

acagcatcgg aggagtccag cgagtgacca ttactgacgc cagacgccgc acctgcccct 16620 acgtttacaa ggccctgggc atagtctcgc cgcgcgtcct atcgagccgc actttttgag 16680 caagcatgtc catccttata tcgcccagca ataacacagg ctggggcctg cgcttcccaa 16740

gcaagatgtt tggcggggcc aagaagcgct ccgaccaaca cccagtgcgc gtgcgcgggc 16800 Page 45

Sequence_Listing.txt actaccgcgc gccctggggc gcgcacaaac gcggccgcac tgggcgcacc accgtcgatg 16860

acgccatcga cgcggtggtg gaggaggcgc gcaactacac gcccacgccg ccaccagtgt 16920 ccacagtgga cgcggccatt cagaccgtgg tgcgcggagc ccggcgctat gctaaaatga 16980

agagacggcg gaggcgcgta gcacgtcgcc accgccgccg acccggcact gccgcccaac 17040 gcgcggcggc ggccctgctt aaccgcgcac gtcgcaccgg ccgacgggcg gccatgcggg 17100 ccgctcgaag gctggccgcg ggtattgtca ctgtgccccc caggtccagg cgacgagcgg 17160

ccgccgcagc agccgcggcc attagtgcta tgactcaggg tcgcaggggc aacgtgtatt 17220 gggtgcgcga ctcggttagc ggcctgcgcg tgcccgtgcg cacccgcccc ccgcgcaact 17280 agattgcaag aaaaaactac ttagactcgt actgttgtat gtatccagcg gcggcggcgc 17340

gcaacgaagc tatgtccaag cgcaaaatca aagaagagat gctccaggtc atcgcgccgg 17400 agatctatgg ccccccgaag aaggaagagc aggattacaa gccccgaaag ctaaagcggg 17460 tcaaaaagaa aaagaaagat gatgatgatg aacttgacga cgaggtggaa ctgctgcacg 17520

ctaccgcgcc caggcgacgg gtacagtgga aaggtcgacg cgtaaaacgt gttttgcgac 17580 ccggcaccac cgtagtcttt acgcccggtg agcgctccac ccgcacctac aagcgcgtgt 17640

atgatgaggt gtacggcgac gaggacctgc ttgagcaggc caacgagcgc ctcggggagt 17700

ttgcctacgg aaagcggcat aaggacatgc tggcgttgcc gctggacgag ggcaacccaa 17760

cacctagcct aaagcccgta acactgcagc aggtgctgcc cgcgcttgca ccgtccgaag 17820

aaaagcgcgg cctaaagcgc gagtctggtg acttggcacc caccgtgcag ctgatggtac 17880 ccaagcgcca gcgactggaa gatgtcttgg aaaaaatgac cgtggaacct gggctggagc 17940

ccgaggtccg cgtgcggcca atcaagcagg tggcgccggg actgggcgtg cagaccgtgg 18000

acgttcagat acccactacc agtagcacca gtattgccac cgccacagag ggcatggaga 18060 cacaaacgtc cccggttgcc tcagcggtgg cggatgccgc ggtgcaggcg gtcgctgcgg 18120

ccgcgtccaa gacctctacg gaggtgcaaa cggacccgtg gatgtttcgc gtttcagccc 18180 cccggcgccc gcgcggttcg aggaagtacg gcgccgccag cgcgctactg cccgaatatg 18240 ccctacatcc ttccattgcg cctacccccg gctatcgtgg ctacacctac cgccccagaa 18300

gacgagcaac tacccgacgc cgaaccacca ctggaacccg ccgccgccgt cgccgtcgcc 18360 agcccgtgct ggccccgatt tccgtgcgca gggtggctcg cgaaggaggc aggaccctgg 18420 tgctgccaac agcgcgctac caccccagca tcgtttaaaa gccggtcttt gtggttcttg 18480

cagatatggc cctcacctgc cgcctccgtt tcccggtgcc gggattccga ggaagaatgc 18540 accgtaggag gggcatggcc ggccacggcc tgacgggcgg catgcgtcgt gcgcaccacc 18600

ggcggcggcg cgcgtcgcac cgtcgcatgc gcggcggtat cctgcccctc cttattccac 18660 tgatcgccgc ggcgattggc gccgtgcccg gaattgcatc cgtggccttg caggcgcaga 18720 gacactgatt aaaaacaagt tgcatgtgga aaaatcaaaa taaaaagtct ggactctcac 18780

gctcgcttgg tcctgtaact attttgtaga atggaagaca tcaactttgc gtctctggcc 18840 Page 46

Sequence_Listing.txt ccgcgacacg gctcgcgccc gttcatggga aactggcaag atatcggcac cagcaatatg 18900

agcggtggcg ccttcagctg gggctcgctg tggagcggca ttaaaaattt cggttccacc 18960 gttaagaact atggcagcaa ggcctggaac agcagcacag gccagatgct gagggataag 19020

ttgaaagagc aaaatttcca acaaaaggtg gtagatggcc tggcctctgg cattagcggg 19080 gtggtggacc tggccaacca ggcagtgcaa aataagatta acagtaagct tgatccccgc 19140 cctcccgtag aggagcctcc accggccgtg gagacagtgt ctccagaggg gcgtggcgaa 19200

aagcgtccgc gccccgacag ggaagaaact ctggtgacgc aaatagacga gcctccctcg 19260 tacgaggagg cactaaagca aggcctgccc accacccgtc ccatcgcgcc catggctacc 19320 ggagtgctgg gccagcacac acccgtaacg ctggacctgc ctccccccgc cgacacccag 19380

cagaaacctg tgctgccagg cccgaccgcc gttgttgtaa cccgtcctag ccgcgcgtcc 19440 ctgcgccgcg ccgccagcgg tccgcgatcg ttgcggcccg tagccagtgg caactggcaa 19500 agcacactga acagcatcgt gggtctgggg gtgcaatccc tgaagcgccg acgatgcttc 19560

tgaatagcta acgtgtcgta tgtgtgtcat gtatgcgtcc atgtcgccgc cagaggagct 19620 gctgagccgc cgcgcgcccg ctttccaaga tggctacccc ttcgatgatg ccgcagtggt 19680

cttacatgca catctcgggc caggacgcct cggagtacct gagccccggg ctggtgcagt 19740

ttgcccgcgc caccgagacg tacttcagcc tgaataacaa gtttagaaac cccacggtgg 19800

cgcctacgca cgacgtgacc acagaccggt cccagcgttt gacgctgcgg ttcatccctg 19860

tggaccgtga ggatactgcg tactcgtaca aggcgcggtt caccctagct gtgggtgata 19920 accgtgtgct ggacatggct tccacgtact ttgacatccg cggcgtgctg gacaggggcc 19980

ctacttttaa gccctactct ggcactgcct acaacgccct ggctcccaag ggtgccccaa 20040

atccttgcga atgggatgaa gctgctactg ctcttgaaat aaacctagaa gaagaggacg 20100 atgacaacga agacgaagta gacgagcaag ctgagcagca aaaaactcac gtatttgggc 20160

aggcgcctta ttctggtata aatattacaa aggagggtat tcaaataggt gtcgaaggtc 20220 aaacacctaa atatgccgat aaaacatttc aacctgaacc tcaaatagga gaatctcagt 20280 ggtacgaaac tgaaattaat catgcagctg ggagagtcct taaaaagact accccaatga 20340

aaccatgtta cggttcatat gcaaaaccca caaatgaaaa tggagggcaa ggcattcttg 20400 taaagcaaca aaatggaaag ctagaaagtc aagtggaaat gcaatttttc tcaactactg 20460 aggcgaccgc aggcaatggt gataacttga ctcctaaagt ggtattgtac agtgaagatg 20520

tagatataga aaccccagac actcatattt cttacatgcc cactattaag gaaggtaact 20580 cacgagaact aatgggccaa caatctatgc ccaacaggcc taattacatt gcttttaggg 20640

acaattttat tggtctaatg tattacaaca gcacgggtaa tatgggtgtt ctggcgggcc 20700 aagcatcgca gttgaatgct gttgtagatt tgcaagacag aaacacagag ctttcatacc 20760 agcttttgct tgattccatt ggtgatagaa ccaggtactt ttctatgtgg aatcaggctg 20820

ttgacagcta tgatccagat gttagaatta ttgaaaatca tggaactgaa gatgaacttc 20880 Page 47

Sequence_Listing.txt caaattactg ctttccactg ggaggtgtga ttaatacaga gactcttacc aaggtaaaac 20940

ctaaaacagg tcaggaaaat ggatgggaaa aagatgctac agaattttca gataaaaatg 21000 aaataagagt tggaaataat tttgccatgg aaatcaatct aaatgccaac ctgtggagaa 21060

atttcctgta ctccaacata gcgctgtatt tgcccgacaa gctaaagtac agtccttcca 21120 acgtaaaaat ttctgataac ccaaacacct acgactacat gaacaagcga gtggtggctc 21180 ccgggttagt ggactgctac attaaccttg gagcacgctg gtcccttgac tatatggaca 21240

acgtcaaccc atttaaccac caccgcaatg ctggcctgcg ctaccgctca atgttgctgg 21300 gcaatggtcg ctatgtgccc ttccacatcc aggtgcctca gaagttcttt gccattaaaa 21360 acctccttct cctgccgggc tcatacacct acgagtggaa cttcaggaag gatgttaaca 21420

tggttctgca gagctcccta ggaaatgacc taagggttga cggagccagc attaagtttg 21480 atagcatttg cctttacgcc accttcttcc ccatggccca caacaccgcc tccacgcttg 21540 aggccatgct tagaaacgac accaacgacc agtcctttaa cgactatctc tccgccgcca 21600

acatgctcta ccctataccc gccaacgcta ccaacgtgcc catatccatc ccctcccgca 21660 actgggcggc tttccgcggc tgggccttca cgcgccttaa gactaaggaa accccatcac 21720

tgggctcggg ctacgaccct tattacacct actctggctc tataccctac ctagatggaa 21780

ccttttacct caaccacacc tttaagaagg tggccattac ctttgactct tctgtcagct 21840

ggcctggcaa tgaccgcctg cttaccccca acgagtttga aattaagcgc tcagttgacg 21900

gggagggtta caacgttgcc cagtgtaaca tgaccaaaga ctggttcctg gtacaaatgc 21960 tagctaacta caacattggc taccagggct tctatatccc agagagctac aaggaccgca 22020

tgtactcctt ctttagaaac ttccagccca tgagccgtca ggtggtggat gatactaaat 22080

acaaggacta ccaacaggtg ggcatcctac accaacacaa caactctgga tttgttggct 22140 accttgcccc caccatgcgc gaaggacagg cctaccctgc taacttcccc tatccgctta 22200

taggcaagac cgcagttgac agcattaccc agaaaaagtt tctttgcgat cgcacccttt 22260 ggcgcatccc attctccagt aactttatgt ccatgggcgc actcacagac ctgggccaaa 22320 accttctcta cgccaactcc gcccacgcgc tagacatgac ttttgaggtg gatcccatgg 22380

acgagcccac ccttctttat gttttgtttg aagtctttga cgtggtccgt gtgcaccggc 22440 cgcaccgcgg cgtcatcgaa accgtgtacc tgcgcacgcc cttctcggcc ggcaacgcca 22500 caacataaag aagcaagcaa catcaacaac agctgccgcc atgggctcca gtgagcagga 22560

actgaaagcc attgtcaaag atcttggttg tgggccatat tttttgggca cctatgacaa 22620 gcgctttcca ggctttgttt ctccacacaa gctcgcctgc gccatagtca atacggccgg 22680

tcgcgagact gggggcgtac actggatggc ctttgcctgg aacccgcact caaaaacatg 22740 ctacctcttt gagccctttg gcttttctga ccagcgactc aagcaggttt accagtttga 22800 gtacgagtca ctcctgcgcc gtagcgccat tgcttcttcc cccgaccgct gtataacgct 22860

ggaaaagtcc acccaaagcg tacaggggcc caactcggcc gcctgtggac tattctgctg 22920 Page 48

Sequence_Listing.txt catgtttctc cacgcctttg ccaactggcc ccaaactccc atggatcaca accccaccat 22980

gaaccttatt accggggtac ccaactccat gctcaacagt ccccaggtac agcccaccct 23040 gcgtcgcaac caggaacagc tctacagctt cctggagcgc cactcgccct acttccgcag 23100

ccacagtgcg cagattagga gcgccacttc tttttgtcac ttgaaaaaca tgtaaaaata 23160 atgtactaga gacactttca ataaaggcaa atgcttttat ttgtacactc tcgggtgatt 23220 atttaccccc acccttgccg tctgcgccgt ttaaaaatca aaggggttct gccgcgcatc 23280

gctatgcgcc actggcaggg acacgttgcg atactggtgt ttagtgctcc acttaaactc 23340 aggcacaacc atccgcggca gctcggtgaa gttttcactc cacaggctgc gcaccatcac 23400 caacgcgttt agcaggtcgg gcgccgatat cttgaagtcg cagttggggc ctccgccctg 23460

cgcgcgcgag ttgcgataca cagggttgca gcactggaac actatcagcg ccgggtggtg 23520 cacgctggcc agcacgctct tgtcggagat cagatccgcg tccaggtcct ccgcgttgct 23580 cagggcgaac ggagtcaact ttggtagctg ccttcccaaa aagggcgcgt gcccaggctt 23640

tgagttgcac tcgcaccgta gtggcatcaa aaggtgaccg tgcccggtct gggcgttagg 23700 atacagcgcc tgcataaaag ccttgatctg cttaaaagcc acctgagcct ttgcgccttc 23760

agagaagaac atgccgcaag acttgccgga aaactgattg gccggacagg ccgcgtcgtg 23820

cacgcagcac cttgcgtcgg tgttggagat ctgcaccaca tttcggcccc accggttctt 23880

cacgatcttg gccttgctag actgctcctt cagcgcgcgc tgcccgtttt cgctcgtcac 23940

atccatttca atcacgtgct ccttatttat cataatgctt ccgtgtagac acttaagctc 24000 gccttcgatc tcagcgcagc ggtgcagcca caacgcgcag cccgtgggct cgtgatgctt 24060

gtaggtcacc tctgcaaacg actgcaggta cgcctgcagg aatcgcccca tcatcgtcac 24120

aaaggtcttg ttgctggtga aggtcagctg caacccgcgg tgctcctcgt tcagccaggt 24180 cttgcatacg gccgccagag cttccacttg gtcaggcagt agtttgaagt tcgcctttag 24240

atcgttatcc acgtggtact tgtccatcag cgcgcgcgca gcctccatgc ccttctccca 24300 cgcagacacg atcggcacac tcagcgggtt catcaccgta atttcacttt ccgcttcgct 24360 gggctcttcc tcttcctctt gcgtccgcat accacgcgcc actgggtcgt cttcattcag 24420

ccgccgcact gtgcgcttac ctcctttgcc atgcttgatt agcaccggtg ggttgctgaa 24480 acccaccatt tgtagcgcca catcttctct ttcttcctcg ctgtccacga ttacctctgg 24540 tgatggcggg cgctcgggct tgggagaagg gcgcttcttt ttcttcttgg gcgcaatggc 24600

caaatccgcc gccgaggtcg atggccgcgg gctgggtgtg cgcggcacca gcgcgtcttg 24660 tgatgagtct tcctcgtcct cggactcgat acgccgcctc atccgctttt ttgggggcgc 24720

ccggggaggc ggcggcgacg gggacgggga cgacacgtcc tccatggttg ggggacgtcg 24780 cgccgcaccg cgtccgcgct cgggggtggt ttcgcgctgc tcctcttccc gactggccat 24840 ttccttctcc tataggcaga aaaagatcat ggagtcagtc gagaagaagg acagcctaac 24900

cgccccctct gagttcgcca ccaccgcctc caccgatgcc gccaacgcgc ctaccacctt 24960 Page 49

Sequence_Listing.txt ccccgtcgag gcacccccgc ttgaggagga ggaagtgatt atcgagcagg acccaggttt 25020

tgtaagcgaa gacgacgagg accgctcagt accaacagag gataaaaagc aagaccagga 25080 caacgcagag gcaaacgagg aacaagtcgg gcggggggac gaaaggcatg gcgactacct 25140

agatgtggga gacgacgtgc tgttgaagca tctgcagcgc cagtgcgcca ttatctgcga 25200 cgcgttgcaa gagcgcagcg atgtgcccct cgccatagcg gatgtcagcc ttgcctacga 25260 acgccaccta ttctcaccgc gcgtaccccc caaacgccaa gaaaacggca catgcgagcc 25320

caacccgcgc ctcaacttct accccgtatt tgccgtgcca gaggtgcttg ccacctatca 25380 catctttttc caaaactgca agatacccct atcctgccgt gccaaccgca gccgagcgga 25440 caagcagctg gccttgcggc agggcgctgt catacctgat atcgcctcgc tcaacgaagt 25500

gccaaaaatc tttgagggtc ttggacgcga cgagaagcgc gcggcaaacg ctctgcaaca 25560 ggaaaacagc gaaaatgaaa gtcactctgg agtgttggtg gaactcgagg gtgacaacgc 25620 gcgcctagcc gtactaaaac gcagcatcga ggtcacccac tttgcctacc cggcacttaa 25680

cctacccccc aaggtcatga gcacagtcat gagtgagctg atcgtgcgcc gtgcgcagcc 25740 cctggagagg gatgcaaatt tgcaagaaca aacagaggag ggcctacccg cagttggcga 25800

cgagcagcta gcgcgctggc ttcaaacgcg cgagcctgcc gacttggagg agcgacgcaa 25860

actaatgatg gccgcagtgc tcgttaccgt ggagcttgag tgcatgcagc ggttctttgc 25920

tgacccggag atgcagcgca agctagagga aacattgcac tacacctttc gacagggcta 25980

cgtacgccag gcctgcaaga tctccaacgt ggagctctgc aacctggtct cctaccttgg 26040 aattttgcac gaaaaccgcc ttgggcaaaa cgtgcttcat tccacgctca agggcgaggc 26100

gcgccgcgac tacgtccgcg actgcgttta cttatttcta tgctacacct ggcagacggc 26160

catgggcgtt tggcagcagt gcttggagga gtgcaacctc aaggagctgc agaaactgct 26220 aaagcaaaac ttgaaggacc tatggacggc cttcaacgag cgctccgtgg ccgcgcacct 26280

ggcggacatc attttccccg aacgcctgct taaaaccctg caacagggtc tgccagactt 26340 caccagtcaa agcatgttgc agaactttag gaactttatc ctagagcgct caggaatctt 26400 gcccgccacc tgctgtgcac ttcctagcga ctttgtgccc attaagtacc gcgaatgccc 26460

tccgccgctt tggggccact gctaccttct gcagctagcc aactaccttg cctaccactc 26520 tgacataatg gaagacgtga gcggtgacgg tctactggag tgtcactgtc gctgcaacct 26580 atgcaccccg caccgctccc tggtttgcaa ttcgcagctg cttaacgaaa gtcaaattat 26640

cggtaccttt gagctgcagg gtccctcgcc tgacgaaaag tccgcggctc cggggttgaa 26700 actcactccg gggctgtgga cgtcggctta ccttcgcaaa tttgtacctg aggactacca 26760

cgcccacgag attaggttct acgaagacca atcccgcccg ccaaatgcgg agcttaccgc 26820 ctgcgtcatt acccagggcc acattcttgg ccaattgcaa gccatcaaca aagcccgcca 26880 agagtttctg ctacgaaagg gacggggggt ttacttggac ccccagtccg gcgaggagct 26940

caacccaatc cccccgccgc cgcagcccta tcagcagcag ccgcgggccc ttgcttccca 27000 Page 50

Sequence_Listing.txt ggatggcacc caaaaagaag ctgcagctgc cgccgccacc cacggacgag gaggaatact 27060

gggacagtca ggcagaggag gttttggacg aggaggagga ggacatgatg gaagactggg 27120 agagcctaga cgaggaagct tccgaggtcg aagaggtgtc agacgaaaca ccgtcaccct 27180

cggtcgcatt cccctcgccg gcgccccaga aatcggcaac cggttccagc atggctacaa 27240 cctccgctcc tcaggcgccg ccggcactgc ccgttcgccg acccaaccgt agatgggaca 27300 ccactggaac cagggccggt aagtccaagc agccgccgcc gttagcccaa gagcaacaac 27360

agcgccaagg ctaccgctca tggcgcgggc acaagaacgc catagttgct tgcttgcaag 27420 actgtggggg caacatctcc ttcgcccgcc gctttcttct ctaccatcac ggcgtggcct 27480 tcccccgtaa catcctgcat tactaccgtc atctctacag cccatactgc accggcggca 27540

gcggcagcgg cagcaacagc agcggccaca cagaagcaaa ggcgaccgga tagcaagact 27600 ctgacaaagc ccaagaaatc cacagcggcg gcagcagcag gaggaggagc gctgcgtctg 27660 gcgcccaacg aacccgtatc gacccgcgag cttagaaaca ggatttttcc cactctgtat 27720

gctatatttc aacagagcag gggccaagaa caagagctga aaataaaaaa caggtctctg 27780 cgatccctca cccgcagctg cctgtatcac aaaagcgaag atcagcttcg gcgcacgctg 27840

gaagacgcgg aggctctctt cagtaaatac tgcgcgctga ctcttaagga ctagtttcgc 27900

gccctttctc aaatttaagc gcgaaaacta cgtcatctcc agcggccaca cccggcgcca 27960

gcacctgtcg tcagcgccat ttcaactttg tatacaaaag ttgtgatgag caaggaaatt 28020

cccacgccct acatgtggag ttaccagcca caaatgggac ttgcggctgg agctgcccaa 28080 gactactcaa cccgaataaa ctacatgagc gcgggacccc acatgatatc ccgggtcaac 28140

ggaatacgcg cccaccgaaa ccgaattctc ctggaacagg cggctattac caccacacct 28200

cgtaataacc ttaatccccg tagttggccc gctgccctgg tgtaccagga aagtcccgct 28260 cccaccactg tggtacttcc cagagacgcc caggccgaag ttcagatgac taactcaggg 28320

gcgcagcttg cgggcggctt tcgtcacagg gtgcggtcgc ccgggcaggg tataactcac 28380 ctgacaatca gagggcgagg tattcagctc aacgacgagt cggtgagctc ctcgcttggt 28440 ctccgtccgg acgggacatt tcagatcggc ggcgccggcc gctcttcatt cacgcctcgt 28500

caggcaatcc taactctgca gacctcgtcc tctgagccgc gctctggagg cattggaact 28560 ctgcaattta ttgaggagtt tgtgccatcg gtctacttta accccttctc gggacctccc 28620 ggccactatc cggatcaatt tattcctaac tttgacgcgg taaaggactc ggcggacggc 28680

tacgactgaa tgttaagtgg agaggcagag caactgcgcc tgaaacacct ggtccactgt 28740 cgccgccaca agtgctttgc ccgcgactcc ggtgagtttt gctactttga attgcccgag 28800

gatcatatcg agggcccggc gcacggcgtc cggcttaccg cccagggaga gcttgcccgt 28860 agcctgattc gggagtttac ccagcgcccc ctgctagttg agcgggacag gggaccctgt 28920 gttctcactg tgatttgcaa ctgtcctaac cctggattac atcaagatct ttgttgccat 28980

ctctgtgctg agtataataa atacagaaat taaaatatac tggggctcct atcgccatcc 29040 Page 51

Sequence_Listing.txt tgtaaacgcc accgtcttca cccgcccaag caaaccaagg cgaaccttac ctggtacttt 29100

taacatctct ccctctgtga tttacaacag tttcaaccca gacggagtga gtctacgaga 29160 gaacctctcc gagctcagct actccatcag aaaaaacacc accctcctta cctgccggga 29220

acgtacgagt gcgtcaccgg ccgctgcacc acacctaccg cctgaccgta aaccagactt 29280 tttccggaca gacctcaata actctgttta ccagaacagg aggtgagctt agaaaaccct 29340 tagggtatta ggccaaaggc gcagctactg tggggtttat gaacaattca agcaactcta 29400

cgggctattc taattcaggt ttctctagaa tcggggttgg ggttattctc tgtcttgtga 29460 ttctctttat tcttatacta acgcttctct gcctaaggct cgccgcctgc tgtgtgcaca 29520 tttgcattta ttgtcagctt tttaaacgct ggggtcgcca cccaagatga ttaggtacat 29580

aatcctaggt ttactcaccc ttgcgtcagc ccacggtacc acccaaaagg tggattttaa 29640 ggagccagcc tgtaatgtta cattcgcagc tgaagctaat gagtgcacca ctcttataaa 29700 atgcaccaca gaacatgaaa agctgcttat tcgccacaaa aacaaaattg gcaagtatgc 29760

tgtttatgct atttggcagc caggtgacac tacagagtat aatgttacag ttttccaggg 29820 taaaagtcat aaaactttta tgtatacttt tccattttat gaaatgtgcg acattaccat 29880

gtacatgagc aaacagtata agttgtggcc cccacaaaat tgtgtggaaa acactggcac 29940

tttctgctgc actgctatgc taattacagt gctcgctttg gtctgtaccc tactctatat 30000

taaatacaaa agcagacgca gctttattga ggaaaagaaa atgccttaat ttactaagtt 30060

acaaagctaa tgtcaccact aactgcttta ctcgctgctt gcaaaacaaa ttcaaaaagt 30120 tagcattata attagaatag gatttaaacc ccccggtcat ttcctgctca ataccattcc 30180

cctgaacaat tgactctatg tgggatatgc tccagcgcta caaccttgaa gtcaggcttc 30240

ctggatgtca gcatctgact ttggccagca cctgtcccgc ggatttgttc cagtccaact 30300 acagcgaccc accctaacag agatgaccaa cacaaccaac gcggccgccg ctaccggact 30360

tacatctacc acaaatacac cccaagtttc tgcctttgtc aataactggg ataacttggg 30420 catgtggtgg ttctccatag cgcttatgtt tgtatgcctt attattatgt ggctcatctg 30480 ctgcctaaag cgcaaacgcg cccgaccacc catctatagt cccatcattg tgctacaccc 30540

aaacaatgat ggaatccata gattggacgg actgaaacac atgttctttt ctcttacagt 30600 atgattaaat gagacatgat tcctcgagtt tttatattac tgacccttgt tgcgcttttt 30660 tgtgcgtgct ccacattggc tgcggtttct cacatcgaag tagactgcat tccagccttc 30720

acagtctatt tgctttacgg atttgtcacc ctcacgctca tctgcagcct catcactgtg 30780 gtcatcgcct ttatccagtg cattgactgg gtctgtgtgc gctttgcata tctcagacac 30840

catccccagt acagggacag gactatagct gagcttctta gaattcttta attatgaaat 30900 ttactgtgac ttttctgctg attatttgca ccctatctgc gttttgttcc ccgacctcca 30960 agcctcaaag acatatatca tgcagattca ctcgtatatg gaatattcca agttgctaca 31020

atgaaaaaag cgatctttcc gaagcctggt tatatgcaat catctctgtt atggtgttct 31080 Page 52

Sequence_Listing.txt gcagtaccat cttagcccta gctatatatc cctaccttga cattggctgg aacgcaatag 31140

atgccatgaa ccacccaact ttccccgcgc ccgctatgct tccactgcaa caagttgttg 31200 ccggcggctt tgtcccagcc aatcagcctc gcccaccttc tcccaccccc actgaaatca 31260

gctactttaa tctaacagga ggagatgact gacaccctag atctagaaat ggacggaatt 31320 attacagagc agcgcctgct agaaagacgc agggcagcgg ccgagcaaca gcgcatgaat 31380 caagagctcc aagacatggt taacttgcac cagtgcaaaa ggggtatctt ttgtctggta 31440

aagcaggcca aagtcaccta cgacagtaat accaccggac accgccttag ctacaagttg 31500 ccaaccaagc gtcagaaatt ggtggtcatg gtgggagaaa agcccattac cataactcag 31560 cactcggtag aaaccgaagg ctgcattcac tcaccttgtc aaggacctga ggatctctgc 31620

acccttatta agaccctgtg cggtctcaaa gatcttattc cctttaacta ataaaaaaaa 31680 ataataaagc atcacttact taaaatcagt tagcaaattt ctgtccagtt tattcagcag 31740 cacctccttg ccctcctccc agctctggta ttgcagcttc ctcctggctg caaactttct 31800

ccacaatcta aatggaatgt cagtttcctc ctgttcctgt ccatccgcac ccactatctt 31860 catgttgttg cagatgaagc gcgcaagacc gtctgaagat accttcaacc ccgtgtatcc 31920

atatgacacg gaaaccggtc ctccaactgt gccttttctt actcctccct ttgtatcccc 31980

caatgggttt caagagagtc cccctggggt actctctttg cgcctatccg aacctctagt 32040

tacctccaat ggcatgcttg cgctcaaaat gggcaacggc ctctctctgg acgaggccgg 32100

caaccttacc tcccaaaatg taaccactgt gagcccacct ctcaaaaaaa ccaagtcaaa 32160 cataaacctg gaaatatctg cacccctcac agttacctca gaagccctaa ctgtggctgc 32220

cgccgcacct ctaatggtcg cgggcaacac actcaccatg caatcacagg ccccgctaac 32280

cgtgcacgac tccaaactta gcattgccac ccaaggaccc ctcacagtgt cagaaggaaa 32340 gctagccctg caaacatcag gccccctcac caccaccgat agcagtaccc ttactatcac 32400

tgcctcaccc cctctaacta ctgccactgg tagcttgggc attgacttga aagagcccat 32460 ttatacacaa aatggaaaac taggactaaa gtacggggct cctttgcatg taacagacga 32520 cctaaacact ttgaccgtag caactggtcc aggtgtgact attaataata cttccttgca 32580

aactaaagtt actggagcct tgggttttga ttcacaaggc aatatgcaac ttaatgtagc 32640 aggaggacta aggattgatt ctcaaaacag acgccttata cttgatgtta gttatccgtt 32700 tgatgctcaa aaccaactaa atctaagact aggacagggc cctcttttta taaactcagc 32760

ccacaacttg gatattaact acaacaaagg cctttacttg tttacagctt caaacaattc 32820 caaaaagctt gaggttaacc taagcactgc caaggggttg atgtttgacg ctacagccat 32880

agccattaat gcaggagatg ggcttgaatt tggttcacct aatgcaccaa acacaaatcc 32940 cctcaaaaca aaaattggcc atggcctaga atttgattca aacaaggcta tggttcctaa 33000 actaggaact ggccttagtt ttgacagcac aggtgccatt acagtaggaa acaaaaataa 33060

tgataagcta actttgtgga ccacaccagc tccatctcct aactgtagac taaatgcaga 33120 Page 53

Sequence_Listing.txt gaaagatgct aaactcactt tggtcttaac aaaatgtggc agtcaaatac ttgctacagt 33180

ttcagttttg gctgttaaag gcagtttggc tccaatatct ggaacagttc aaagtgctca 33240 tcttattata agatttgacg aaaatggagt gctactaaac aattccttcc tggacccaga 33300

atattggaac tttagaaatg gagatcttac tgaaggcaca gcctatacaa acgctgttgg 33360 atttatgcct aacctatcag cttatccaaa atctcacggt aaaactgcca aaagtaacat 33420 tgtcagtcaa gtttacttaa acggagacaa aactaaacct gtaacactaa ccattacact 33480

aaacggtaca caggaaacag gagacacaac tccaagtgca tactctatgt cattttcatg 33540 ggactggtct ggccacaact acattaatga aatatttgcc acatcctctt acactttttc 33600 atacattgcc caagaataaa gaatcgtttg tgttatgttt caacgtgttt atttttcaat 33660

tgcagaaaat ttcaagtcat ttttcattca gtagtatagc cccaccacca catagcttat 33720 acagatcacc gtacctcaac tttgtataat aaagttgtaa tcaaactcac agaaccctag 33780 tattcaacct gccacctccc tcccaacaca cagagtacac agtcctttct ccccggctgg 33840

ccttaaaaag catcatatca tgggtaacag acatattctt aggtgttata ttccacacgg 33900 tttcctgtcg agccaaacgc tcatcagtga tattaataaa ctccccgggc agctcactta 33960

agttcatgtc gctgtccagc tgctgagcca caggctgctg tccaacttgc ggttgcttaa 34020

cgggcggcga aggagaagtc cacgcctaca tgggggtaga gtcataatcg tgcatcagga 34080

tagggcggtg gtgctgcagc agcgcgcgaa taaactgctg ccgccgccgc tccgtcctgc 34140

aggaatacaa catggcagtg gtctcctcag cgatgattcg caccgcccgc agcataaggc 34200 gccttgtcct ccgggcacag cagcgcaccc tgatctcact taaatcagca cagtaactgc 34260

agcacagcac cacaatattg ttcaaaatcc cacagtgcaa ggcgctgtat ccaaagctca 34320

tggcggggac cacagaaccc acgtggccat cataccacaa gcgcaggtag attaagtggc 34380 gacccctcat aaacacgctg gacataaaca ttacctcttt tggcatgttg taattcacca 34440

cctcccggta ccatataaac ctctgattaa acatggcgcc atccaccacc atcctaaacc 34500 agctggccaa aacctgcccg ccggctatac actgcaggga accgggactg gaacaatgac 34560 agtggagagc ccaggactcg taaccatgga tcatcatgct cgtcatgata tcaatgttgg 34620

cacaacacag gcacacgtgc atacacttcc tcaggattac aagctcctcc cgcgttagaa 34680 ccatatccca gggaacaacc cattcctgaa tcagcgtaaa tcccacactg cagggaagac 34740 ctcgcacgta actcacgttg tgcattgtca aagtgttaca ttcgggcagc agcggatgat 34800

cctccagtat ggtagcgcgg gtttctgtct caaaaggagg tagacgatcc ctactgtacg 34860 gagtgcgccg agacaaccga gatcgtgttg gtcgtagtgt catgccaaat ggaacgccgg 34920

acgtagtcat atttcctgaa gcaaaaccag gtgcgggcgt gacaaacaga tctgcgtctc 34980 cggtctcgcc gcttagatcg ctctgtgtag tagttgtagt atatccactc tctcaaagca 35040 tccaggcgcc ccctggcttc gggttctatg taaactcctt catgcgccgc tgccctgata 35100

acatccacca ccgcagaata agccacaccc agccaaccta cacattcgtt ctgcgagtca 35160 Page 54

Sequence_Listing.txt cacacgggag gagcgggaag agctggaaga accatgtttt tttttttatt ccaaaagatt 35220

atccaaaacc tcaaaatgaa gatctattaa gtgaacgcgc tcccctccgg tggcgtggtc 35280 aaactctaca gccaaagaac agataatggc atttgtaaga tgttgcacaa tggcttccaa 35340

aaggcaaacg gccctcacgt ccaagtggac gtaaaggcta aacccttcag ggtgaatctc 35400 ctctataaac attccagcac cttcaaccat gcccaaataa ttctcatctc gccaccttct 35460 caatatatct ctaagcaaat cccgaatatt aagtccggcc attgtaaaaa tctgctccag 35520

agcgccctcc accttcagcc tcaagcagcg aatcatgatt gcaaaaattc aggttcctca 35580 cagacctgta taagattcaa aagcggaaca ttaacaaaaa taccgcgatc ccgtaggtcc 35640 cttcgcaggg ccagctgaac ataatcgtgc aggtctgcac ggaccagcgc ggccacttcc 35700

ccgccaggaa ccatgacaaa agaacccaca ctgattatga cacgcatact cggagctatg 35760 ctaaccagcg tagccccgat gtaagcttgt tgcatgggcg gcgatataaa atgcaaggtg 35820 ctgctcaaaa aatcaggcaa agcctcgcgc aaaaaagaaa gcacatcgta gtcatgctca 35880

tgcagataaa ggcaggtaag ctccggaacc accacagaaa aagacaccat ttttctctca 35940 aacatgtctg cgggtttctg cataaacaca aaataaaata acaaaaaaac atttaaacat 36000

tagaagcctg tcttacaaca ggaaaaacaa cccttataag cataagacgg actacggcca 36060

tgccggcgtg accgtaaaaa aactggtcac cgtgattaaa aagcaccacc gacagctcct 36120

cggtcatgtc cggagtcata atgtaagact cggtaaacac atcaggttga ttcacatcgg 36180

tcagtgctaa aaagcgaccg aaatagcccg ggggaataca tacccgcagg cgtagagaca 36240 acattacagc ccccatagga ggtataacaa aattaatagg agagaaaaac acataaacac 36300

ctgaaaaacc ctcctgccta ggcaaaatag caccctcccg ctccagaaca acatacagcg 36360

cttccacagc ggcagccata acagtcagcc ttaccagtaa aaaagaaaac ctattaaaaa 36420 aacaccactc gacacggcac cagctcaatc agtcacagtg taaaaaaggg ccaagtgcag 36480

agcgagtata tataggacta aaaaatgacg taacggttaa agtccacaaa aaacacccag 36540 aaaaccgcac gcgaacctac gcccagaaac gaaagccaaa aaacccacaa cttcctcaaa 36600 tcgtcacttc cgttttccca cgttacgtca cttcccattt taagaaaact acaattccca 36660

acacatacaa gttactccgc cctaaaacct acgtcacccg ccccgttccc acgccccgcg 36720 ccacgtcaca aactccaccc cctcattatc atattggctt caatccaaaa taaggtatat 36780 tattgatgat g 36791

<210> 4 <211> 36782 <212> DNA <213> Artificial Sequence <220> <223> Synthetic adenovirus genome E1B-55k-P2A-mCherry <400> 4 catcatcaat aatatacctt attttggatt gaagccaata tgataatgag ggggtggagt 60 Page 55

Sequence_Listing.txt ttgtgacgtg gcgcggggcg tgggaacggg gcgggtgacg tagtagtgtg gcggaagtgt 120

gatgttgcaa gtgtggcgga acacatgtaa gcgacggatg tggcaaaagt gacgtttttg 180 gtgtgcgccg gtgtacacag gaagtgacaa ttttcgcgcg gttttaggcg gatgttgtag 240

taaatttggg cgtaaccgag taagatttgg ccattttcgc gggaaaactg aataagagga 300 agtgaaatct gaataatttt gtgttactca tagcgcgtaa tatttgtcta gggccgcggg 360 gactttgacc gtttacgtgg agactcgccc aggtgttttt ctcaggtgtt ttccgcgttc 420

cgggtcaaag ttggcgtttt attattatag tcagctgacg tgtagtgtat ttatacccgg 480 tgagttcctc aagaggccac tcttgagtgc cagcgagtag agttttctcc tccgagccgc 540 tccgacaccg ggactgaaaa tgagacatat tatctgccac ggaggtgtta ttaccgaaga 600

aatggccgcc agtcttttgg accagctgat cgaagaggta ctggctgata atcttccacc 660 tcctagccat tttgaaccac ctacccttca cgaactgtat gatttagacg tgacggcccc 720 cgaagatccc aacgaggagg cggtttcgca gatttttccc gactctgtaa tgttggcggt 780

gcaggaaggg attgacttac tcacttttcc gccggcgccc ggttctccgg agccgcctca 840 cctttcccgg cagcccgagc agccggagca gagagccttg ggtccggttt ctatgccaaa 900

ccttgtaccg gaggtgatcg atcttacctg ccacgaggct ggctttccac ccagtgacga 960

cgaggatgaa gagggtgagg agtttgtgtt agattatgtg gagcaccccg ggcacggttg 1020

caggtcttgt cattatcacc ggaggaatac gggggaccca gatattatgt gttcgctttg 1080

ctatatgagg acctgtggca tgtttgtcta cagtaagtga aaattatggg cagtgggtga 1140 tagagtggtg ggtttggtgt ggtaattttt tttttaattt ttacagtttt gtggtttaaa 1200

gaattttgta ttgtgatttt tttaaaaggt cctgtgtctg aacctgagcc tgagcccgag 1260

ccagaaccgg agcctgcaag acctacccgc cgtcctaaaa tggcgcctgc tatcctgaga 1320 cgcccgacat cacctgtgtc tagagaatgc aatagtagta cggatagctg tgactccggt 1380

ccttctaaca cacctcctga gatacacccg gtggtcccgc tgtgccccat taaaccagtt 1440 gccgtgagag ttggtgggcg tcgccaggct gtggaatgta tcgaggactt gcttaacgag 1500 cctgggcaac ctttggactt gagctgtaaa cgccccaggc cataaggtgt aaacctgtga 1560

ttgcgtgtgt ggttaacgcc tttgtttgct gaatgagttg atgtaagttt aataaagggt 1620 gagataatgt ttaacttgca tggcgtgtta aatggggcgg ggcttaaagg gtatataatg 1680 cgccgtgggc taatcttggt tacatctgac ctcatggagg cttgggagtg tttggaagat 1740

ttttctgctg tgcgtaactt gctggaacag agctctaaca gtacctcttg gttttggagg 1800 tttctgtggg gctcatccca ggcaaagtta gtctgcagaa ttaaggagga ttacaagtgg 1860

gaatttgaag agcttttgaa atcctgtggt gagctgtttg attctttgaa tctgggtcac 1920 caggcgcttt tccaagagaa ggtcatcaag actttggatt tttccacacc ggggcgcgct 1980 gcggctgctg ttgctttttt gagttttata aaggataaat ggagcgaaga aacccatctg 2040

agcggggggt acctgctgga ttttctggcc atgcatctgt ggagagcggt tgtgagacac 2100 Page 56

Sequence_Listing.txt aagaatcgcc tgctactgtt gtcttccgtc cgcccggcga taataccgac ggaggagcag 2160

cagcagcagc aggaggaagc caggcggcgg cggcaggagc agagcccatg gaacccgaga 2220 gccggcctgg accctcggga atgaatgttg tacaggtggc tgaactgtat ccagaactga 2280

gacgcatttt gacaattaca gaggatgggc aggggctaaa gggggtaaag agggagcggg 2340 gggcttgtga ggctacagag gaggctagga atctagcttt tagcttaatg accagacacc 2400 gtcctgagtg tattactttt caacagatca aggataattg cgctaatgag cttgatctgc 2460

tggcgcagaa gtattccata gagcagctga ccacttactg gctgcagcca ggggatgatt 2520 ttgaggaggc tattagggta tatgcaaagg tggcacttag gccagattgc aagtacaaga 2580 tcagcaaact tgtaaatatc aggaattgtt gctacatttc tgggaacggg gccgaggtgg 2640

agatagatac ggaggatagg gtggccttta gatgtagcat gataaatatg tggccggggg 2700 tgcttggcat ggacggggtg gttattatga atgtaaggtt tactggcccc aattttagcg 2760 gtacggtttt cctggccaat accaacctta tcctacacgg tgtaagcttc tatgggttta 2820

acaatacctg tgtggaagcc tggaccgatg taagggttcg gggctgtgcc ttttactgct 2880 gctggaaggg ggtggtgtgt cgccccaaaa gcagggcttc aattaagaaa tgcctctttg 2940

aaaggtgtac cttgggtatc ctgtctgagg gtaactccag ggtgcgccac aatgtggcct 3000

ccgactgtgg ttgcttcatg ctagtgaaaa gcgtggctgt gattaagcat aacatggtat 3060

gtggcaactg cgaggacagg gcctctcaga tgctgacctg ctcggacggc aactgtcacc 3120

tgctgaagac cattcacgta gccagccact ctcgcaaggc ctggccagtg tttgagcata 3180 acatactgac ccgctgttcc ttgcatttgg gtaacaggag gggggtgttc ctaccttacc 3240

aatgcaattt gagtcacact aagatattgc ttgagcccga gagcatgtcc aaggtgaacc 3300

tgaacggggt gtttgacatg accatgaaga tctggaaggt gctgaggtac gatgagaccc 3360 gcaccaggtg cagaccctgc gagtgtggcg gtaaacatat taggaaccag cctgtgatgc 3420

tggatgtgac cgaggagctg aggcccgatc acttggtgct ggcctgcacc cgcgctgagt 3480 ttggctctag cgatgaagat acagatggaa gcggagctac taacttcagc ctgctgaagc 3540 aggctggtga cgtcgaggag aatcctggcc caatggtgag caagggcgag gaggataaca 3600

tggccatcat caaggagttc atgcgcttca aggtgcacat ggagggctcc gtgaacggcc 3660 acgagttcga gatcgagggc gagggcgagg gccgccccta cgagggcacc cagaccgcca 3720 agctgaaggt gaccaagggt ggccccctgc ccttcgcctg ggacatcctg tcccctcagt 3780

tcatgtacgg ctccaaggcc tacgtgaagc accccgccga catccccgac tacttgaagc 3840 tgtccttccc cgagggcttc aagtgggagc gcgtgatgaa cttcgaggac ggcggcgtgg 3900

tgaccgtgac ccaggactcc tccctgcagg acggcgagtt catctacaag gtgaagctgc 3960 gcggcaccaa cttcccctcc gacggccccg taatgcagaa gaagaccatg ggctgggagg 4020 cctcctccga gcggatgtac cccgaggacg gcgccctgaa gggcgagatc aagcagaggc 4080

tgaagctgaa ggacggcggc cactacgacg ctgaggtcaa gaccacctac aaggccaaga 4140 Page 57

Sequence_Listing.txt agcccgtgca gctgcccggc gcctacaacg tcaacatcaa gttggacatc acctcccaca 4200

acgaggacta caccatcgtg gaacagtacg aacgcgccga gggccgccac tccaccggcg 4260 gcatggacga gctgtacaag tgaggtactg aaatgtgtgg gcgtggctta agggtgggaa 4320

agaatatata aggtgggggt cttatgtagt tttgtatctg ttttgcagca gccgccgccg 4380 cccaactttt ctatacaaag ttgtaatgag caccaactcg tttgatggaa gcattgtgag 4440 ctcatatttg acaacgcgca tgcccccatg ggccggggtg cgtcagaatg tgatgggctc 4500

cagcattgat ggtcgccccg tcctgcccgc aaactctact accttgacct acgagaccgt 4560 gtctggaacg ccgttggaga ctgcagcctc cgccgccgct tcagccgctg cagccaccgc 4620 ccgcgggatt gtgactgact ttgctttcct gagcccgctt gcaagcagtg cagcttcccg 4680

ttcatccgcc cgcgatgaca agttgacggc tcttttggca caattggatt ctttgacccg 4740 ggaacttaat gtcgtttctc agcagctgtt ggatctgcgc cagcaggttt ctgccctgaa 4800 ggcttcctcc cctcccaatg cggtttaaaa cataaataaa aaaccagact ctgtttggat 4860

ttggatcaag cataagtgtc ttgctgtctt tatttagggg ttttgcgcgc gcggtaggcc 4920 cgggaccagc ggtctcggtc gttgagggtc ctgtgtattt tttccaggac gtggtaaagg 4980

tgactctgga tgttcagata catgggcata agcccgtctc tggggtggag gtagcaccac 5040

tgcagagctt catgctgcgg ggtggtgttg tagatgatcc agtcgtagca ggagcgctgg 5100

gcgtggtgcc taaaaatgtc tttcagtagc aagctgattg ccaggggcag gcccttggtg 5160

taagtgttta caaagcggtt aagctgggat gggtgcatac gtggggatat gagatgcatc 5220 ttggactgta tttttaggtt ggctatgttc ccagccatat ccctccgggg attcatgttg 5280

tgcagaacca ccagcacagt gtatccggtg cacttgggaa atttgtcatg tagcttagaa 5340

ggaaatgcgt ggaagaactt ggagacgccc ttgtgacctc caagattttc catgcattcg 5400 tccataatga tggcaatggg cccacgggcg gcggcctggg cgaagatatt tctgggatca 5460

ctaacgtcat agttgtgttc caggatgaga tcgtcatagg ccatttttac aaagcgcggg 5520 cggagggtgc cagactgcgg tataatggtt ccatccggcc caggggcgta gttaccctca 5580 cagatttgca tttcccacgc tttgagttca gatgggggga tcatgtctac ctgcggggcg 5640

atgaagaaaa cggtttccgg ggtaggggag atcagctggg aagaaagcag gttcctgagc 5700 agctgcgact taccgcagcc ggtgggcccg taaatcacac ctattaccgg gtgcaactgg 5760 tagttaagag agctgcagct gccgtcatcc ctgagcaggg gggccacttc gttaagcatg 5820

tccctgactc gcatgttttc cctgaccaaa tccgccagaa ggcgctcgcc gcccagcgat 5880 agcagttctt gcaaggaagc aaagtttttc aacggtttga gaccgtccgc cgtaggcatg 5940

cttttgagcg tttgaccaag cagttccagg cggtcccaca gctcggtcac ctgctctacg 6000 gcatctcgat ccagcatatc tcctcgtttc gcgggttggg gcggctttcg ctgtacggca 6060 gtagtcggtg ctcgtccaga cgggccaggg tcatgtcttt ccacgggcgc agggtcctcg 6120

tcagcgtagt ctgggtcacg gtgaaggggt gcgctccggg ctgcgcgctg gccagggtgc 6180 Page 58

Sequence_Listing.txt gcttgaggct ggtcctgctg gtgctgaagc gctgccggtc ttcgccctgc gcgtcggcca 6240

ggtagcattt gaccatggtg tcatagtcca gcccctccgc ggcgtggccc ttggcgcgca 6300 gcttgccctt ggaggaggcg ccgcacgagg ggcagtgcag acttttgagg gcgtagagct 6360

tgggcgcgag aaataccgat tccggggagt aggcatccgc gccgcaggcc ccgcagacgg 6420 tctcgcattc cacgagccag gtgagctctg gccgttcggg gtcaaaaacc aggtttcccc 6480 catgcttttt gatgcgtttc ttacctctgg tttccatgag ccggtgtcca cgctcggtga 6540

cgaaaaggct gtccgtgtcc ccgtatacag acttgagagg cctgtcctcg agcggtgttc 6600 cgcggtcctc ctcgtataga aactcggacc actctgagac aaaggctcgc gtccaggcca 6660 gcacgaagga ggctaagtgg gaggggtagc ggtcgttgtc cactaggggg tccactcgct 6720

ccagggtgtg aagacacatg tcgccctctt cggcatcaag gaaggtgatt ggtttgtagg 6780 tgtaggccac gtgaccgggt gttcctgaag gggggctata aaagggggtg ggggcgcgtt 6840 cgtcctcact ctcttccgca tcgctgtctg cgagggccag ctgttggggt gagtactccc 6900

tctgaaaagc gggcatgact tctgcgctaa gattgtcagt ttccaaaaac gaggaggatt 6960 tgatattcac ctggcccgcg gtgatgcctt tgagggtggc cgcatccatc tggtcagaaa 7020

agacaatctt tttgttgtca agcttggtgg caaacgaccc gtagagggcg ttggacagca 7080

acttggcgat ggagcgcagg gtttggtttt tgtcgcgatc ggcgcgctcc ttggccgcga 7140

tgtttagctg cacgtattcg cgcgcaacgc accgccattc gggaaagacg gtggtgcgct 7200

cgtcgggcac caggtgcacg cgccaaccgc ggttgtgcag ggtgacaagg tcaacgctgg 7260 tggctacctc tccgcgtagg cgctcgttgg tccagcagag gcggccgccc ttgcgcgagc 7320

agaatggcgg tagggggtct agctgcgtct cgtccggggg gtctgcgtcc acggtaaaga 7380

ccccgggcag caggcgcgcg tcgaagtagt ctatcttgca tccttgcaag tctagcgcct 7440 gctgccatgc gcgggcggca agcgcgcgct cgtatgggtt gagtggggga ccccatggca 7500

tggggtgggt gagcgcggag gcgtacatgc cgcaaatgtc gtaaacgtag aggggctctc 7560 tgagtattcc aagatatgta gggtagcatc ttccaccgcg gatgctggcg cgcacgtaat 7620 cgtatagttc gtgcgaggga gcgaggaggt cgggaccgag gttgctacgg gcgggctgct 7680

ctgctcggaa gactatctgc ctgaagatgg catgtgagtt ggatgatatg gttggacgct 7740 ggaagacgtt gaagctggcg tctgtgagac ctaccgcgtc acgcacgaag gaggcgtagg 7800 agtcgcgcag cttgttgacc agctcggcgg tgacctgcac gtctagggcg cagtagtcca 7860

gggtttcctt gatgatgtca tacttatcct gtcccttttt tttccacagc tcgcggttga 7920 ggacaaactc ttcgcggtct ttccagtact cttggatcgg aaacccgtcg gcctccgaac 7980

ggtaagagcc tagcatgtag aactggttga cggcctggta ggcgcagcat cccttttcta 8040 cgggtagcgc gtatgcctgc gcggccttcc ggagcgaggt gtgggtgagc gcaaaggtgt 8100 ccctgaccat gactttgagg tactggtatt tgaagtcagt gtcgtcgcat ccgccctgct 8160

cccagagcaa aaagtccgtg cgctttttgg aacgcggatt tggcagggcg aaggtgacat 8220 Page 59

Sequence_Listing.txt cgttgaagag tatctttccc gcgcgaggca taaagttgcg tgtgatgcgg aagggtcccg 8280

gcacctcgga acggttgtta attacctggg cggcgagcac gatctcgtca aagccgttga 8340 tgttgtggcc cacaatgtaa agttccaaga agcgcgggat gcccttgatg gaaggcaatt 8400

ttttaagttc ctcgtaggtg agctcttcag gggagctgag cccgtgctct gaaagggccc 8460 agtctgcaag atgagggttg gaagcgacga atgagctcca caggtcacgg gccattagca 8520 tttgcaggtg gtcgcgaaag gtcctaaact ggcgacctat ggccattttt tctggggtga 8580

tgcagtagaa ggtaagcggg tcttgttccc agcggtccca tccaaggttc gcggctaggt 8640 ctcgcgcggc agtcactaga ggctcatctc cgccgaactt catgaccagc atgaagggca 8700 cgagctgctt cccaaaggcc cccatccaag tataggtctc tacatcgtag gtgacaaaga 8760

gacgctcggt gcgaggatgc gagccgatcg ggaagaactg gatctcccgc caccaattgg 8820 aggagtggct attgatgtgg tgaaagtaga agtccctgcg acgggccgaa cactcgtgct 8880 ggcttttgta aaaacgtgcg cagtactggc agcggtgcac gggctgtaca tcctgcacga 8940

ggttgacctg acgaccgcgc acaaggaagc agagtgggaa tttgagcccc tcgcctggcg 9000 ggtttggctg gtggtcttct acttcggctg cttgtccttg accgtctggc tgctcgaggg 9060

gagttacggt ggatcggacc accacgccgc gcgagcccaa agtccagatg tccgcgcgcg 9120

gcggtcggag cttgatgaca acatcgcgca gatgggagct gtccatggtc tggagctccc 9180

gcggcgtcag gtcaggcggg agctcctgca ggtttacctc gcatagacgg gtcagggcgc 9240

gggctagatc caggtgatac ctaatttcca ggggctggtt ggtggcggcg tcgatggctt 9300 gcaagaggcc gcatccccgc ggcgcgacta cggtaccgcg cggcgggcgg tgggccgcgg 9360

gggtgtcctt ggatgatgca tctaaaagcg gtgacgcggg cgagcccccg gaggtagggg 9420

gggctccgga cccgccggga gagggggcag gggcacgtcg gcgccgcgcg cgggcaggag 9480 ctggtgctgc gcgcgtaggt tgctggcgaa cgcgacgacg cggcggttga tctcctgaat 9540

ctggcgcctc tgcgtgaaga cgacgggccc ggtgagcttg agcctgaaag agagttcgac 9600 agaatcaatt tcggtgtcgt tgacggcggc ctggcgcaaa atctcctgca cgtctcctga 9660 gttgtcttga taggcgatct cggccatgaa ctgctcgatc tcttcctcct ggagatctcc 9720

gcgtccggct cgctccacgg tggcggcgag gtcgttggaa atgcgggcca tgagctgcga 9780 gaaggcgttg aggcctccct cgttccagac gcggctgtag accacgcccc cttcggcatc 9840 gcgggcgcgc atgaccacct gcgcgagatt gagctccacg tgccgggcga agacggcgta 9900

gtttcgcagg cgctgaaaga ggtagttgag ggtggtggcg gtgtgttctg ccacgaagaa 9960 gtacataacc cagcgtcgca acgtggattc gttgatatcc cccaaggcct caaggcgctc 10020

catggcctcg tagaagtcca cggcgaagtt gaaaaactgg gagttgcgcg ccgacacggt 10080 taactcctcc tccagaagac ggatgagctc ggcgacagtg tcgcgcacct cgcgctcaaa 10140 ggctacaggg gcctcttctt cttcttcaat ctcctcttcc ataagggcct ccccttcttc 10200

ttcttctggc ggcggtgggg gaggggggac acggcggcga cgacggcgca ccgggaggcg 10260 Page 60

Sequence_Listing.txt gtcgacaaag cgctcgatca tctccccgcg gcgacggcgc atggtctcgg tgacggcgcg 10320

gccgttctcg cgggggcgca gttggaagac gccgcccgtc atgtcccggt tatgggttgg 10380 cggggggctg ccatgcggca gggatacggc gctaacgatg catctcaaca attgttgtgt 10440

aggtactccg ccgccgaggg acctgagcga gtccgcatcg accggatcgg aaaacctctc 10500 gagaaaggcg tctaaccagt cacagtcgca aggtaggctg agcaccgtgg cgggcggcag 10560 cgggcggcgg tcggggttgt ttctggcgga ggtgctgctg atgatgtaat taaagtaggc 10620

ggtcttgaga cggcggatgg tcgacagaag caccatgtcc ttgggtccgg cctgctgaat 10680 gcgcaggcgg tcggccatgc cccaggcttc gttttgacat cggcgcaggt ctttgtagta 10740 gtcttgcatg agcctttcta ccggcacttc ttcttctcct tcctcttgtc ctgcatctct 10800

tgcatctatc gctgcggcgg cggcggagtt tggccgtagg tggcgccctc ttcctcccat 10860 gcgtgtgacc ccgaagcccc tcatcggctg aagcagggct aggtcggcga caacgcgctc 10920 ggctaatatg gcctgctgca cctgcgtgag ggtagactgg aagtcatcca tgtccacaaa 10980

gcggtggtat gcgcccgtgt tgatggtgta agtgcagttg gccataacgg accagttaac 11040 ggtctggtga cccggctgcg agagctcggt gtacctgaga cgcgagtaag ccctcgagtc 11100

aaatacgtag tcgttgcaag tccgcaccag gtactggtat cccaccaaaa agtgcggcgg 11160

cggctggcgg tagaggggcc agcgtagggt ggccggggct ccgggggcga gatcttccaa 11220

cataaggcga tgatatccgt agatgtacct ggacatccag gtgatgccgg cggcggtggt 11280

ggaggcgcgc ggaaagtcgc ggacgcggtt ccagatgttg cgcagcggca aaaagtgctc 11340 catggtcggg acgctctggc cggtcaggcg cgcgcaatcg ttgacgctct agaccgtgca 11400

aaaggagagc ctgtaagcgg gcactcttcc gtggtctggt ggataaattc gcaagggtat 11460

catggcggac gaccggggtt cgagccccgt atccggccgt ccgccgtgat ccatgcggtt 11520 accgcccgcg tgtcgaaccc aggtgtgcga cgtcagacaa cgggggagtg ctccttttgg 11580

cttccttcca ggcgcggcgg ctgctgcgct agcttttttg gccactggcc gcgcgcagcg 11640 taagcggtta ggctggaaag cgaaagcatt aagtggctcg ctccctgtag ccggagggtt 11700 attttccaag ggttgagtcg cgggaccccc ggttcgagtc tcggaccggc cggactgcgg 11760

cgaacggggg tttgcctccc cgtcatgcaa gaccccgctt gcaaattcct ccggaaacag 11820 ggacgagccc cttttttgct tttcccagat gcatccggtg ctgcggcaga tgcgcccccc 11880 tcctcagcag cggcaagagc aagagcagcg gcagacatgc agggcaccct cccctcctcc 11940

taccgcgtca ggaggggcga catccgcggt tgacgcggca gcagatggtg attacgaacc 12000 cccgcggcgc cgggcccggc actacctgga cttggaggag ggcgagggcc tggcgcggct 12060

aggagcgccc tctcctgagc ggtacccaag ggtgcagctg aagcgtgata cgcgtgaggc 12120 gtacgtgccg cggcagaacc tgtttcgcga ccgcgaggga gaggagcccg aggagatgcg 12180 ggatcgaaag ttccacgcag ggcgcgagct gcggcatggc ctgaatcgcg agcggttgct 12240

gcgcgaggag gactttgagc ccgacgcgcg aaccgggatt agtcccgcgc gcgcacacgt 12300 Page 61

Sequence_Listing.txt ggcggccgcc gacctggtaa ccgcatacga gcagacggtg aaccaggaga ttaactttca 12360

aaaaagcttt aacaaccacg tgcgtacgct tgtggcgcgc gaggaggtgg ctataggact 12420 gatgcatctg tgggactttg taagcgcgct ggagcaaaac ccaaatagca agccgctcat 12480

ggcgcagctg ttccttatag tgcagcacag cagggacaac gaggcattca gggatgcgct 12540 gctaaacata gtagagcccg agggccgctg gctgctcgat ttgataaaca tcctgcagag 12600 catagtggtg caggagcgca gcttgagcct ggctgacaag gtggccgcca tcaactattc 12660

catgcttagc ctgggcaagt tttacgcccg caagatatac catacccctt acgttcccat 12720 agacaaggag gtaaagatcg aggggttcta catgcgcatg gcgctgaagg tgcttacctt 12780 gagcgacgac ctgggcgttt atcgcaacga gcgcatccac aaggccgtga gcgtgagccg 12840

gcggcgcgag ctcagcgacc gcgagctgat gcacagcctg caaagggccc tggctggcac 12900 gggcagcggc gatagagagg ccgagtccta ctttgacgcg ggcgctgacc tgcgctgggc 12960 cccaagccga cgcgccctgg aggcagctgg ggccggacct gggctggcgg tggcacccgc 13020

gcgcgctggc aacgtcggcg gcgtggagga atatgacgag gacgatgagt acgagccaga 13080 ggacggcgag tactaagcgg tgatgtttct gatcagatga tgcaagacgc aacggacccg 13140

gcggtgcggg cggcgctgca gagccagccg tccggcctta actccacgga cgactggcgc 13200

caggtcatgg accgcatcat gtcgctgact gcgcgcaatc ctgacgcgtt ccggcagcag 13260

ccgcaggcca accggctctc cgcaattctg gaagcggtgg tcccggcgcg cgcaaacccc 13320

acgcacgaga aggtgctggc gatcgtaaac gcgctggccg aaaacagggc catccggccc 13380 gacgaggccg gcctggtcta cgacgcgctg cttcagcgcg tggctcgtta caacagcggc 13440

aacgtgcaga ccaacctgga ccggctggtg ggggatgtgc gcgaggccgt ggcgcagcgt 13500

gagcgcgcgc agcagcaggg caacctgggc tccatggttg cactaaacgc cttcctgagt 13560 acacagcccg ccaacgtgcc gcggggacag gaggactaca ccaactttgt gagcgcactg 13620

cggctaatgg tgactgagac accgcaaagt gaggtgtacc agtctgggcc agactatttt 13680 ttccagacca gtagacaagg cctgcagacc gtaaacctga gccaggcttt caaaaacttg 13740 caggggctgt ggggggtgcg ggctcccaca ggcgaccgcg cgaccgtgtc tagcttgctg 13800

acgcccaact cgcgcctgtt gctgctgcta atagcgccct tcacggacag tggcagcgtg 13860 tcccgggaca catacctagg tcacttgctg acactgtacc gcgaggccat aggtcaggcg 13920 catgtggacg agcatacttt ccaggagatt acaagtgtca gccgcgcgct ggggcaggag 13980

gacacgggca gcctggaggc aaccctaaac tacctgctga ccaaccggcg gcagaagatc 14040 ccctcgttgc acagtttaaa cagcgaggag gagcgcattt tgcgctacgt gcagcagagc 14100

gtgagcctta acctgatgcg cgacggggta acgcccagcg tggcgctgga catgaccgcg 14160 cgcaacatgg aaccgggcat gtatgcctca aaccggccgt ttatcaaccg cctaatggac 14220 tacttgcatc gcgcggccgc cgtgaacccc gagtatttca ccaatgccat cttgaacccg 14280

cactggctac cgccccctgg tttctacacc gggggattcg aggtgcccga gggtaacgat 14340 Page 62

Sequence_Listing.txt ggattcctct gggacgacat agacgacagc gtgttttccc cgcaaccgca gaccctgcta 14400

gagttgcaac agcgcgagca ggcagaggcg gcgctgcgaa aggaaagctt ccgcaggcca 14460 agcagcttgt ccgatctagg cgctgcggcc ccgcggtcag atgctagtag cccatttcca 14520

agcttgatag ggtctcttac cagcactcgc accacccgcc cgcgcctgct gggcgaggag 14580 gagtacctaa acaactcgct gctgcagccg cagcgcgaaa aaaacctgcc tccggcattt 14640 cccaacaacg ggatagagag cctagtggac aagatgagta gatggaagac gtacgcgcag 14700

gagcacaggg acgtgccagg cccgcgcccg cccacccgtc gtcaaaggca cgaccgtcag 14760 cggggtctgg tgtgggagga cgatgactcg gcagacgaca gcagcgtcct ggatttggga 14820 gggagtggca acccgtttgc gcaccttcgc cccaggctgg ggagaatgtt ttaaaaaaaa 14880

aaaagcatga tgcaaaataa aaaactcacc aaggccatgg caccgagcgt tggttttctt 14940 gtattcccct tagtatgcgg cgcgcggcga tgtatgagga aggtcctcct ccctcctacg 15000 agagtgtggt gagcgcggcg ccagtggcgg cggcgctggg ttctcccttc gatgctcccc 15060

tggacccgcc gtttgtgcct ccgcggtacc tgcggcctac cggggggaga aacagcatcc 15120 gttactctga gttggcaccc ctattcgaca ccacccgtgt gtacctggtg gacaacaagt 15180

caacggatgt ggcatccctg aactaccaga acgaccacag caactttctg accacggtca 15240

ttcaaaacaa tgactacagc ccgggggagg caagcacaca gaccatcaat cttgacgacc 15300

ggtcgcactg gggcggcgac ctgaaaacca tcctgcatac caacatgcca aatgtgaacg 15360

agttcatgtt taccaataag tttaaggcgc gggtgatggt gtcgcgcttg cctactaagg 15420 acaatcaggt ggagctgaaa tacgagtggg tggagttcac gctgcccgag ggcaactact 15480

ccgagaccat gaccatagac cttatgaaca acgcgatcgt ggagcactac ttgaaagtgg 15540

gcagacagaa cggggttctg gaaagcgaca tcggggtaaa gtttgacacc cgcaacttca 15600 gactggggtt tgaccccgtc actggtcttg tcatgcctgg ggtatataca aacgaagcct 15660

tccatccaga catcattttg ctgccaggat gcggggtgga cttcacccac agccgcctga 15720 gcaacttgtt gggcatccgc aagcggcaac ccttccagga gggctttagg atcacctacg 15780 atgatctgga gggtggtaac attcccgcac tgttggatgt ggacgcctac caggcgagct 15840

tgaaagatga caccgaacag ggcgggggtg gcgcaggcgg cagcaacagc agtggcagcg 15900 gcgcggaaga gaactccaac gcggcagccg cggcaatgca gccggtggag gacatgaacg 15960 atcatgccat tcgcggcgac acctttgcca cacgggctga ggagaagcgc gctgaggccg 16020

aagcagcggc cgaagctgcc gcccccgctg cgcaacccga ggtcgagaag cctcagaaga 16080 aaccggtgat caaacccctg acagaggaca gcaagaaacg cagttacaac ctaataagca 16140

atgacagcac cttcacccag taccgcagct ggtaccttgc atacaactac ggcgaccctc 16200 agaccggaat ccgctcatgg accctgcttt gcactcctga cgtaacctgc ggctcggagc 16260 aggtctactg gtcgttgcca gacatgatgc aagaccccgt gaccttccgc tccacgcgcc 16320

agatcagcaa ctttccggtg gtgggcgccg agctgttgcc cgtgcactcc aagagcttct 16380 Page 63

Sequence_Listing.txt acaacgacca ggccgtctac tcccaactca tccgccagtt tacctctctg acccacgtgt 16440

tcaatcgctt tcccgagaac cagattttgg cgcgcccgcc agcccccacc atcaccaccg 16500 tcagtgaaaa cgttcctgct ctcacagatc acgggacgct accgctgcgc aacagcatcg 16560

gaggagtcca gcgagtgacc attactgacg ccagacgccg cacctgcccc tacgtttaca 16620 aggccctggg catagtctcg ccgcgcgtcc tatcgagccg cactttttga gcaagcatgt 16680 ccatccttat atcgcccagc aataacacag gctggggcct gcgcttccca agcaagatgt 16740

ttggcggggc caagaagcgc tccgaccaac acccagtgcg cgtgcgcggg cactaccgcg 16800 cgccctgggg cgcgcacaaa cgcggccgca ctgggcgcac caccgtcgat gacgccatcg 16860 acgcggtggt ggaggaggcg cgcaactaca cgcccacgcc gccaccagtg tccacagtgg 16920

acgcggccat tcagaccgtg gtgcgcggag cccggcgcta tgctaaaatg aagagacggc 16980 ggaggcgcgt agcacgtcgc caccgccgcc gacccggcac tgccgcccaa cgcgcggcgg 17040 cggccctgct taaccgcgca cgtcgcaccg gccgacgggc ggccatgcgg gccgctcgaa 17100

ggctggccgc gggtattgtc actgtgcccc ccaggtccag gcgacgagcg gccgccgcag 17160 cagccgcggc cattagtgct atgactcagg gtcgcagggg caacgtgtat tgggtgcgcg 17220

actcggttag cggcctgcgc gtgcccgtgc gcacccgccc cccgcgcaac tagattgcaa 17280

gaaaaaacta cttagactcg tactgttgta tgtatccagc ggcggcggcg cgcaacgaag 17340

ctatgtccaa gcgcaaaatc aaagaagaga tgctccaggt catcgcgccg gagatctatg 17400

gccccccgaa gaaggaagag caggattaca agccccgaaa gctaaagcgg gtcaaaaaga 17460 aaaagaaaga tgatgatgat gaacttgacg acgaggtgga actgctgcac gctaccgcgc 17520

ccaggcgacg ggtacagtgg aaaggtcgac gcgtaaaacg tgttttgcga cccggcacca 17580

ccgtagtctt tacgcccggt gagcgctcca cccgcaccta caagcgcgtg tatgatgagg 17640 tgtacggcga cgaggacctg cttgagcagg ccaacgagcg cctcggggag tttgcctacg 17700

gaaagcggca taaggacatg ctggcgttgc cgctggacga gggcaaccca acacctagcc 17760 taaagcccgt aacactgcag caggtgctgc ccgcgcttgc accgtccgaa gaaaagcgcg 17820 gcctaaagcg cgagtctggt gacttggcac ccaccgtgca gctgatggta cccaagcgcc 17880

agcgactgga agatgtcttg gaaaaaatga ccgtggaacc tgggctggag cccgaggtcc 17940 gcgtgcggcc aatcaagcag gtggcgccgg gactgggcgt gcagaccgtg gacgttcaga 18000 tacccactac cagtagcacc agtattgcca ccgccacaga gggcatggag acacaaacgt 18060

ccccggttgc ctcagcggtg gcggatgccg cggtgcaggc ggtcgctgcg gccgcgtcca 18120 agacctctac ggaggtgcaa acggacccgt ggatgtttcg cgtttcagcc ccccggcgcc 18180

cgcgcggttc gaggaagtac ggcgccgcca gcgcgctact gcccgaatat gccctacatc 18240 cttccattgc gcctaccccc ggctatcgtg gctacaccta ccgccccaga agacgagcaa 18300 ctacccgacg ccgaaccacc actggaaccc gccgccgccg tcgccgtcgc cagcccgtgc 18360

tggccccgat ttccgtgcgc agggtggctc gcgaaggagg caggaccctg gtgctgccaa 18420 Page 64

Sequence_Listing.txt cagcgcgcta ccaccccagc atcgtttaaa agccggtctt tgtggttctt gcagatatgg 18480

ccctcacctg ccgcctccgt ttcccggtgc cgggattccg aggaagaatg caccgtagga 18540 ggggcatggc cggccacggc ctgacgggcg gcatgcgtcg tgcgcaccac cggcggcggc 18600

gcgcgtcgca ccgtcgcatg cgcggcggta tcctgcccct ccttattcca ctgatcgccg 18660 cggcgattgg cgccgtgccc ggaattgcat ccgtggcctt gcaggcgcag agacactgat 18720 taaaaacaag ttgcatgtgg aaaaatcaaa ataaaaagtc tggactctca cgctcgcttg 18780

gtcctgtaac tattttgtag aatggaagac atcaactttg cgtctctggc cccgcgacac 18840 ggctcgcgcc cgttcatggg aaactggcaa gatatcggca ccagcaatat gagcggtggc 18900 gccttcagct ggggctcgct gtggagcggc attaaaaatt tcggttccac cgttaagaac 18960

tatggcagca aggcctggaa cagcagcaca ggccagatgc tgagggataa gttgaaagag 19020 caaaatttcc aacaaaaggt ggtagatggc ctggcctctg gcattagcgg ggtggtggac 19080 ctggccaacc aggcagtgca aaataagatt aacagtaagc ttgatccccg ccctcccgta 19140

gaggagcctc caccggccgt ggagacagtg tctccagagg ggcgtggcga aaagcgtccg 19200 cgccccgaca gggaagaaac tctggtgacg caaatagacg agcctccctc gtacgaggag 19260

gcactaaagc aaggcctgcc caccacccgt cccatcgcgc ccatggctac cggagtgctg 19320

ggccagcaca cacccgtaac gctggacctg cctccccccg ccgacaccca gcagaaacct 19380

gtgctgccag gcccgaccgc cgttgttgta acccgtccta gccgcgcgtc cctgcgccgc 19440

gccgccagcg gtccgcgatc gttgcggccc gtagccagtg gcaactggca aagcacactg 19500 aacagcatcg tgggtctggg ggtgcaatcc ctgaagcgcc gacgatgctt ctgaatagct 19560

aacgtgtcgt atgtgtgtca tgtatgcgtc catgtcgccg ccagaggagc tgctgagccg 19620

ccgcgcgccc gctttccaag atggctaccc cttcgatgat gccgcagtgg tcttacatgc 19680 acatctcggg ccaggacgcc tcggagtacc tgagccccgg gctggtgcag tttgcccgcg 19740

ccaccgagac gtacttcagc ctgaataaca agtttagaaa ccccacggtg gcgcctacgc 19800 acgacgtgac cacagaccgg tcccagcgtt tgacgctgcg gttcatccct gtggaccgtg 19860 aggatactgc gtactcgtac aaggcgcggt tcaccctagc tgtgggtgat aaccgtgtgc 19920

tggacatggc ttccacgtac tttgacatcc gcggcgtgct ggacaggggc cctactttta 19980 agccctactc tggcactgcc tacaacgccc tggctcccaa gggtgcccca aatccttgcg 20040 aatgggatga agctgctact gctcttgaaa taaacctaga agaagaggac gatgacaacg 20100

aagacgaagt agacgagcaa gctgagcagc aaaaaactca cgtatttggg caggcgcctt 20160 attctggtat aaatattaca aaggagggta ttcaaatagg tgtcgaaggt caaacaccta 20220

aatatgccga taaaacattt caacctgaac ctcaaatagg agaatctcag tggtacgaaa 20280 ctgaaattaa tcatgcagct gggagagtcc ttaaaaagac taccccaatg aaaccatgtt 20340 acggttcata tgcaaaaccc acaaatgaaa atggagggca aggcattctt gtaaagcaac 20400

aaaatggaaa gctagaaagt caagtggaaa tgcaattttt ctcaactact gaggcgaccg 20460 Page 65

Sequence_Listing.txt caggcaatgg tgataacttg actcctaaag tggtattgta cagtgaagat gtagatatag 20520

aaaccccaga cactcatatt tcttacatgc ccactattaa ggaaggtaac tcacgagaac 20580 taatgggcca acaatctatg cccaacaggc ctaattacat tgcttttagg gacaatttta 20640

ttggtctaat gtattacaac agcacgggta atatgggtgt tctggcgggc caagcatcgc 20700 agttgaatgc tgttgtagat ttgcaagaca gaaacacaga gctttcatac cagcttttgc 20760 ttgattccat tggtgataga accaggtact tttctatgtg gaatcaggct gttgacagct 20820

atgatccaga tgttagaatt attgaaaatc atggaactga agatgaactt ccaaattact 20880 gctttccact gggaggtgtg attaatacag agactcttac caaggtaaaa cctaaaacag 20940 gtcaggaaaa tggatgggaa aaagatgcta cagaattttc agataaaaat gaaataagag 21000

ttggaaataa ttttgccatg gaaatcaatc taaatgccaa cctgtggaga aatttcctgt 21060 actccaacat agcgctgtat ttgcccgaca agctaaagta cagtccttcc aacgtaaaaa 21120 tttctgataa cccaaacacc tacgactaca tgaacaagcg agtggtggct cccgggttag 21180

tggactgcta cattaacctt ggagcacgct ggtcccttga ctatatggac aacgtcaacc 21240 catttaacca ccaccgcaat gctggcctgc gctaccgctc aatgttgctg ggcaatggtc 21300

gctatgtgcc cttccacatc caggtgcctc agaagttctt tgccattaaa aacctccttc 21360

tcctgccggg ctcatacacc tacgagtgga acttcaggaa ggatgttaac atggttctgc 21420

agagctccct aggaaatgac ctaagggttg acggagccag cattaagttt gatagcattt 21480

gcctttacgc caccttcttc cccatggccc acaacaccgc ctccacgctt gaggccatgc 21540 ttagaaacga caccaacgac cagtccttta acgactatct ctccgccgcc aacatgctct 21600

accctatacc cgccaacgct accaacgtgc ccatatccat cccctcccgc aactgggcgg 21660

ctttccgcgg ctgggccttc acgcgcctta agactaagga aaccccatca ctgggctcgg 21720 gctacgaccc ttattacacc tactctggct ctatacccta cctagatgga accttttacc 21780

tcaaccacac ctttaagaag gtggccatta cctttgactc ttctgtcagc tggcctggca 21840 atgaccgcct gcttaccccc aacgagtttg aaattaagcg ctcagttgac ggggagggtt 21900 acaacgttgc ccagtgtaac atgaccaaag actggttcct ggtacaaatg ctagctaact 21960

acaacattgg ctaccagggc ttctatatcc cagagagcta caaggaccgc atgtactcct 22020 tctttagaaa cttccagccc atgagccgtc aggtggtgga tgatactaaa tacaaggact 22080 accaacaggt gggcatccta caccaacaca acaactctgg atttgttggc taccttgccc 22140

ccaccatgcg cgaaggacag gcctaccctg ctaacttccc ctatccgctt ataggcaaga 22200 ccgcagttga cagcattacc cagaaaaagt ttctttgcga tcgcaccctt tggcgcatcc 22260

cattctccag taactttatg tccatgggcg cactcacaga cctgggccaa aaccttctct 22320 acgccaactc cgcccacgcg ctagacatga cttttgaggt ggatcccatg gacgagccca 22380 cccttcttta tgttttgttt gaagtctttg acgtggtccg tgtgcaccgg ccgcaccgcg 22440

gcgtcatcga aaccgtgtac ctgcgcacgc ccttctcggc cggcaacgcc acaacataaa 22500 Page 66

Sequence_Listing.txt gaagcaagca acatcaacaa cagctgccgc catgggctcc agtgagcagg aactgaaagc 22560

cattgtcaaa gatcttggtt gtgggccata ttttttgggc acctatgaca agcgctttcc 22620 aggctttgtt tctccacaca agctcgcctg cgccatagtc aatacggccg gtcgcgagac 22680

tgggggcgta cactggatgg cctttgcctg gaacccgcac tcaaaaacat gctacctctt 22740 tgagcccttt ggcttttctg accagcgact caagcaggtt taccagtttg agtacgagtc 22800 actcctgcgc cgtagcgcca ttgcttcttc ccccgaccgc tgtataacgc tggaaaagtc 22860

cacccaaagc gtacaggggc ccaactcggc cgcctgtgga ctattctgct gcatgtttct 22920 ccacgccttt gccaactggc cccaaactcc catggatcac aaccccacca tgaaccttat 22980 taccggggta cccaactcca tgctcaacag tccccaggta cagcccaccc tgcgtcgcaa 23040

ccaggaacag ctctacagct tcctggagcg ccactcgccc tacttccgca gccacagtgc 23100 gcagattagg agcgccactt ctttttgtca cttgaaaaac atgtaaaaat aatgtactag 23160 agacactttc aataaaggca aatgctttta tttgtacact ctcgggtgat tatttacccc 23220

cacccttgcc gtctgcgccg tttaaaaatc aaaggggttc tgccgcgcat cgctatgcgc 23280 cactggcagg gacacgttgc gatactggtg tttagtgctc cacttaaact caggcacaac 23340

catccgcggc agctcggtga agttttcact ccacaggctg cgcaccatca ccaacgcgtt 23400

tagcaggtcg ggcgccgata tcttgaagtc gcagttgggg cctccgccct gcgcgcgcga 23460

gttgcgatac acagggttgc agcactggaa cactatcagc gccgggtggt gcacgctggc 23520

cagcacgctc ttgtcggaga tcagatccgc gtccaggtcc tccgcgttgc tcagggcgaa 23580 cggagtcaac tttggtagct gccttcccaa aaagggcgcg tgcccaggct ttgagttgca 23640

ctcgcaccgt agtggcatca aaaggtgacc gtgcccggtc tgggcgttag gatacagcgc 23700

ctgcataaaa gccttgatct gcttaaaagc cacctgagcc tttgcgcctt cagagaagaa 23760 catgccgcaa gacttgccgg aaaactgatt ggccggacag gccgcgtcgt gcacgcagca 23820

ccttgcgtcg gtgttggaga tctgcaccac atttcggccc caccggttct tcacgatctt 23880 ggccttgcta gactgctcct tcagcgcgcg ctgcccgttt tcgctcgtca catccatttc 23940 aatcacgtgc tccttattta tcataatgct tccgtgtaga cacttaagct cgccttcgat 24000

ctcagcgcag cggtgcagcc acaacgcgca gcccgtgggc tcgtgatgct tgtaggtcac 24060 ctctgcaaac gactgcaggt acgcctgcag gaatcgcccc atcatcgtca caaaggtctt 24120 gttgctggtg aaggtcagct gcaacccgcg gtgctcctcg ttcagccagg tcttgcatac 24180

ggccgccaga gcttccactt ggtcaggcag tagtttgaag ttcgccttta gatcgttatc 24240 cacgtggtac ttgtccatca gcgcgcgcgc agcctccatg cccttctccc acgcagacac 24300

gatcggcaca ctcagcgggt tcatcaccgt aatttcactt tccgcttcgc tgggctcttc 24360 ctcttcctct tgcgtccgca taccacgcgc cactgggtcg tcttcattca gccgccgcac 24420 tgtgcgctta cctcctttgc catgcttgat tagcaccggt gggttgctga aacccaccat 24480

ttgtagcgcc acatcttctc tttcttcctc gctgtccacg attacctctg gtgatggcgg 24540 Page 67

Sequence_Listing.txt gcgctcgggc ttgggagaag ggcgcttctt tttcttcttg ggcgcaatgg ccaaatccgc 24600

cgccgaggtc gatggccgcg ggctgggtgt gcgcggcacc agcgcgtctt gtgatgagtc 24660 ttcctcgtcc tcggactcga tacgccgcct catccgcttt tttgggggcg cccggggagg 24720

cggcggcgac ggggacgggg acgacacgtc ctccatggtt gggggacgtc gcgccgcacc 24780 gcgtccgcgc tcgggggtgg tttcgcgctg ctcctcttcc cgactggcca tttccttctc 24840 ctataggcag aaaaagatca tggagtcagt cgagaagaag gacagcctaa ccgccccctc 24900

tgagttcgcc accaccgcct ccaccgatgc cgccaacgcg cctaccacct tccccgtcga 24960 ggcacccccg cttgaggagg aggaagtgat tatcgagcag gacccaggtt ttgtaagcga 25020 agacgacgag gaccgctcag taccaacaga ggataaaaag caagaccagg acaacgcaga 25080

ggcaaacgag gaacaagtcg ggcgggggga cgaaaggcat ggcgactacc tagatgtggg 25140 agacgacgtg ctgttgaagc atctgcagcg ccagtgcgcc attatctgcg acgcgttgca 25200 agagcgcagc gatgtgcccc tcgccatagc ggatgtcagc cttgcctacg aacgccacct 25260

attctcaccg cgcgtacccc ccaaacgcca agaaaacggc acatgcgagc ccaacccgcg 25320 cctcaacttc taccccgtat ttgccgtgcc agaggtgctt gccacctatc acatcttttt 25380

ccaaaactgc aagatacccc tatcctgccg tgccaaccgc agccgagcgg acaagcagct 25440

ggccttgcgg cagggcgctg tcatacctga tatcgcctcg ctcaacgaag tgccaaaaat 25500

ctttgagggt cttggacgcg acgagaagcg cgcggcaaac gctctgcaac aggaaaacag 25560

cgaaaatgaa agtcactctg gagtgttggt ggaactcgag ggtgacaacg cgcgcctagc 25620 cgtactaaaa cgcagcatcg aggtcaccca ctttgcctac ccggcactta acctaccccc 25680

caaggtcatg agcacagtca tgagtgagct gatcgtgcgc cgtgcgcagc ccctggagag 25740

ggatgcaaat ttgcaagaac aaacagagga gggcctaccc gcagttggcg acgagcagct 25800 agcgcgctgg cttcaaacgc gcgagcctgc cgacttggag gagcgacgca aactaatgat 25860

ggccgcagtg ctcgttaccg tggagcttga gtgcatgcag cggttctttg ctgacccgga 25920 gatgcagcgc aagctagagg aaacattgca ctacaccttt cgacagggct acgtacgcca 25980 ggcctgcaag atctccaacg tggagctctg caacctggtc tcctaccttg gaattttgca 26040

cgaaaaccgc cttgggcaaa acgtgcttca ttccacgctc aagggcgagg cgcgccgcga 26100 ctacgtccgc gactgcgttt acttatttct atgctacacc tggcagacgg ccatgggcgt 26160 ttggcagcag tgcttggagg agtgcaacct caaggagctg cagaaactgc taaagcaaaa 26220

cttgaaggac ctatggacgg ccttcaacga gcgctccgtg gccgcgcacc tggcggacat 26280 cattttcccc gaacgcctgc ttaaaaccct gcaacagggt ctgccagact tcaccagtca 26340

aagcatgttg cagaacttta ggaactttat cctagagcgc tcaggaatct tgcccgccac 26400 ctgctgtgca cttcctagcg actttgtgcc cattaagtac cgcgaatgcc ctccgccgct 26460 ttggggccac tgctaccttc tgcagctagc caactacctt gcctaccact ctgacataat 26520

ggaagacgtg agcggtgacg gtctactgga gtgtcactgt cgctgcaacc tatgcacccc 26580 Page 68

Sequence_Listing.txt gcaccgctcc ctggtttgca attcgcagct gcttaacgaa agtcaaatta tcggtacctt 26640

tgagctgcag ggtccctcgc ctgacgaaaa gtccgcggct ccggggttga aactcactcc 26700 ggggctgtgg acgtcggctt accttcgcaa atttgtacct gaggactacc acgcccacga 26760

gattaggttc tacgaagacc aatcccgccc gccaaatgcg gagcttaccg cctgcgtcat 26820 tacccagggc cacattcttg gccaattgca agccatcaac aaagcccgcc aagagtttct 26880 gctacgaaag ggacgggggg tttacttgga cccccagtcc ggcgaggagc tcaacccaat 26940

ccccccgccg ccgcagccct atcagcagca gccgcgggcc cttgcttccc aggatggcac 27000 ccaaaaagaa gctgcagctg ccgccgccac ccacggacga ggaggaatac tgggacagtc 27060 aggcagagga ggttttggac gaggaggagg aggacatgat ggaagactgg gagagcctag 27120

acgaggaagc ttccgaggtc gaagaggtgt cagacgaaac accgtcaccc tcggtcgcat 27180 tcccctcgcc ggcgccccag aaatcggcaa ccggttccag catggctaca acctccgctc 27240 ctcaggcgcc gccggcactg cccgttcgcc gacccaaccg tagatgggac accactggaa 27300

ccagggccgg taagtccaag cagccgccgc cgttagccca agagcaacaa cagcgccaag 27360 gctaccgctc atggcgcggg cacaagaacg ccatagttgc ttgcttgcaa gactgtgggg 27420

gcaacatctc cttcgcccgc cgctttcttc tctaccatca cggcgtggcc ttcccccgta 27480

acatcctgca ttactaccgt catctctaca gcccatactg caccggcggc agcggcagcg 27540

gcagcaacag cagcggccac acagaagcaa aggcgaccgg atagcaagac tctgacaaag 27600

cccaagaaat ccacagcggc ggcagcagca ggaggaggag cgctgcgtct ggcgcccaac 27660 gaacccgtat cgacccgcga gcttagaaac aggatttttc ccactctgta tgctatattt 27720

caacagagca ggggccaaga acaagagctg aaaataaaaa acaggtctct gcgatccctc 27780

acccgcagct gcctgtatca caaaagcgaa gatcagcttc ggcgcacgct ggaagacgcg 27840 gaggctctct tcagtaaata ctgcgcgctg actcttaagg actagtttcg cgccctttct 27900

caaatttaag cgcgaaaact acgtcatctc cagcggccac acccggcgcc agcacctgtc 27960 gtcagcgcca tttcaacttt gtatacaaaa gttgtgatga gcaaggaaat tcccacgccc 28020 tacatgtgga gttaccagcc acaaatggga cttgcggctg gagctgccca agactactca 28080

acccgaataa actacatgag cgcgggaccc cacatgatat cccgggtcaa cggaatacgc 28140 gcccaccgaa accgaattct cctggaacag gcggctatta ccaccacacc tcgtaataac 28200 cttaatcccc gtagttggcc cgctgccctg gtgtaccagg aaagtcccgc tcccaccact 28260

gtggtacttc ccagagacgc ccaggccgaa gttcagatga ctaactcagg ggcgcagctt 28320 gcgggcggct ttcgtcacag ggtgcggtcg cccgggcagg gtataactca cctgacaatc 28380

agagggcgag gtattcagct caacgacgag tcggtgagct cctcgcttgg tctccgtccg 28440 gacgggacat ttcagatcgg cggcgccggc cgctcttcat tcacgcctcg tcaggcaatc 28500 ctaactctgc agacctcgtc ctctgagccg cgctctggag gcattggaac tctgcaattt 28560

attgaggagt ttgtgccatc ggtctacttt aaccccttct cgggacctcc cggccactat 28620 Page 69

Sequence_Listing.txt ccggatcaat ttattcctaa ctttgacgcg gtaaaggact cggcggacgg ctacgactga 28680

atgttaagtg gagaggcaga gcaactgcgc ctgaaacacc tggtccactg tcgccgccac 28740 aagtgctttg cccgcgactc cggtgagttt tgctactttg aattgcccga ggatcatatc 28800

gagggcccgg cgcacggcgt ccggcttacc gcccagggag agcttgcccg tagcctgatt 28860 cgggagttta cccagcgccc cctgctagtt gagcgggaca ggggaccctg tgttctcact 28920 gtgatttgca actgtcctaa ccctggatta catcaagatc tttgttgcca tctctgtgct 28980

gagtataata aatacagaaa ttaaaatata ctggggctcc tatcgccatc ctgtaaacgc 29040 caccgtcttc acccgcccaa gcaaaccaag gcgaacctta cctggtactt ttaacatctc 29100 tccctctgtg atttacaaca gtttcaaccc agacggagtg agtctacgag agaacctctc 29160

cgagctcagc tactccatca gaaaaaacac caccctcctt acctgccggg aacgtacgag 29220 tgcgtcaccg gccgctgcac cacacctacc gcctgaccgt aaaccagact ttttccggac 29280 agacctcaat aactctgttt accagaacag gaggtgagct tagaaaaccc ttagggtatt 29340

aggccaaagg cgcagctact gtggggttta tgaacaattc aagcaactct acgggctatt 29400 ctaattcagg tttctctaga atcggggttg gggttattct ctgtcttgtg attctcttta 29460

ttcttatact aacgcttctc tgcctaaggc tcgccgcctg ctgtgtgcac atttgcattt 29520

attgtcagct ttttaaacgc tggggtcgcc acccaagatg attaggtaca taatcctagg 29580

tttactcacc cttgcgtcag cccacggtac cacccaaaag gtggatttta aggagccagc 29640

ctgtaatgtt acattcgcag ctgaagctaa tgagtgcacc actcttataa aatgcaccac 29700 agaacatgaa aagctgctta ttcgccacaa aaacaaaatt ggcaagtatg ctgtttatgc 29760

tatttggcag ccaggtgaca ctacagagta taatgttaca gttttccagg gtaaaagtca 29820

taaaactttt atgtatactt ttccatttta tgaaatgtgc gacattacca tgtacatgag 29880 caaacagtat aagttgtggc ccccacaaaa ttgtgtggaa aacactggca ctttctgctg 29940

cactgctatg ctaattacag tgctcgcttt ggtctgtacc ctactctata ttaaatacaa 30000 aagcagacgc agctttattg aggaaaagaa aatgccttaa tttactaagt tacaaagcta 30060 atgtcaccac taactgcttt actcgctgct tgcaaaacaa attcaaaaag ttagcattat 30120

aattagaata ggatttaaac cccccggtca tttcctgctc aataccattc ccctgaacaa 30180 ttgactctat gtgggatatg ctccagcgct acaaccttga agtcaggctt cctggatgtc 30240 agcatctgac tttggccagc acctgtcccg cggatttgtt ccagtccaac tacagcgacc 30300

caccctaaca gagatgacca acacaaccaa cgcggccgcc gctaccggac ttacatctac 30360 cacaaataca ccccaagttt ctgcctttgt caataactgg gataacttgg gcatgtggtg 30420

gttctccata gcgcttatgt ttgtatgcct tattattatg tggctcatct gctgcctaaa 30480 gcgcaaacgc gcccgaccac ccatctatag tcccatcatt gtgctacacc caaacaatga 30540 tggaatccat agattggacg gactgaaaca catgttcttt tctcttacag tatgattaaa 30600

tgagacatga ttcctcgagt ttttatatta ctgacccttg ttgcgctttt ttgtgcgtgc 30660 Page 70

Sequence_Listing.txt tccacattgg ctgcggtttc tcacatcgaa gtagactgca ttccagcctt cacagtctat 30720

ttgctttacg gatttgtcac cctcacgctc atctgcagcc tcatcactgt ggtcatcgcc 30780 tttatccagt gcattgactg ggtctgtgtg cgctttgcat atctcagaca ccatccccag 30840

tacagggaca ggactatagc tgagcttctt agaattcttt aattatgaaa tttactgtga 30900 cttttctgct gattatttgc accctatctg cgttttgttc cccgacctcc aagcctcaaa 30960 gacatatatc atgcagattc actcgtatat ggaatattcc aagttgctac aatgaaaaaa 31020

gcgatctttc cgaagcctgg ttatatgcaa tcatctctgt tatggtgttc tgcagtacca 31080 tcttagccct agctatatat ccctaccttg acattggctg gaacgcaata gatgccatga 31140 accacccaac tttccccgcg cccgctatgc ttccactgca acaagttgtt gccggcggct 31200

ttgtcccagc caatcagcct cgcccacctt ctcccacccc cactgaaatc agctacttta 31260 atctaacagg aggagatgac tgacacccta gatctagaaa tggacggaat tattacagag 31320 cagcgcctgc tagaaagacg cagggcagcg gccgagcaac agcgcatgaa tcaagagctc 31380

caagacatgg ttaacttgca ccagtgcaaa aggggtatct tttgtctggt aaagcaggcc 31440 aaagtcacct acgacagtaa taccaccgga caccgcctta gctacaagtt gccaaccaag 31500

cgtcagaaat tggtggtcat ggtgggagaa aagcccatta ccataactca gcactcggta 31560

gaaaccgaag gctgcattca ctcaccttgt caaggacctg aggatctctg cacccttatt 31620

aagaccctgt gcggtctcaa agatcttatt ccctttaact aataaaaaaa aataataaag 31680

catcacttac ttaaaatcag ttagcaaatt tctgtccagt ttattcagca gcacctcctt 31740 gccctcctcc cagctctggt attgcagctt cctcctggct gcaaactttc tccacaatct 31800

aaatggaatg tcagtttcct cctgttcctg tccatccgca cccactatct tcatgttgtt 31860

gcagatgaag cgcgcaagac cgtctgaaga taccttcaac cccgtgtatc catatgacac 31920 ggaaaccggt cctccaactg tgccttttct tactcctccc tttgtatccc ccaatgggtt 31980

tcaagagagt ccccctgggg tactctcttt gcgcctatcc gaacctctag ttacctccaa 32040 tggcatgctt gcgctcaaaa tgggcaacgg cctctctctg gacgaggccg gcaaccttac 32100 ctcccaaaat gtaaccactg tgagcccacc tctcaaaaaa accaagtcaa acataaacct 32160

ggaaatatct gcacccctca cagttacctc agaagcccta actgtggctg ccgccgcacc 32220 tctaatggtc gcgggcaaca cactcaccat gcaatcacag gccccgctaa ccgtgcacga 32280 ctccaaactt agcattgcca cccaaggacc cctcacagtg tcagaaggaa agctagccct 32340

gcaaacatca ggccccctca ccaccaccga tagcagtacc cttactatca ctgcctcacc 32400 ccctctaact actgccactg gtagcttggg cattgacttg aaagagccca tttatacaca 32460

aaatggaaaa ctaggactaa agtacggggc tcctttgcat gtaacagacg acctaaacac 32520 tttgaccgta gcaactggtc caggtgtgac tattaataat acttccttgc aaactaaagt 32580 tactggagcc ttgggttttg attcacaagg caatatgcaa cttaatgtag caggaggact 32640

aaggattgat tctcaaaaca gacgccttat acttgatgtt agttatccgt ttgatgctca 32700 Page 71

Sequence_Listing.txt aaaccaacta aatctaagac taggacaggg ccctcttttt ataaactcag cccacaactt 32760

ggatattaac tacaacaaag gcctttactt gtttacagct tcaaacaatt ccaaaaagct 32820 tgaggttaac ctaagcactg ccaaggggtt gatgtttgac gctacagcca tagccattaa 32880

tgcaggagat gggcttgaat ttggttcacc taatgcacca aacacaaatc ccctcaaaac 32940 aaaaattggc catggcctag aatttgattc aaacaaggct atggttccta aactaggaac 33000 tggccttagt tttgacagca caggtgccat tacagtagga aacaaaaata atgataagct 33060

aactttgtgg accacaccag ctccatctcc taactgtaga ctaaatgcag agaaagatgc 33120 taaactcact ttggtcttaa caaaatgtgg cagtcaaata cttgctacag tttcagtttt 33180 ggctgttaaa ggcagtttgg ctccaatatc tggaacagtt caaagtgctc atcttattat 33240

aagatttgac gaaaatggag tgctactaaa caattccttc ctggacccag aatattggaa 33300 ctttagaaat ggagatctta ctgaaggcac agcctataca aacgctgttg gatttatgcc 33360 taacctatca gcttatccaa aatctcacgg taaaactgcc aaaagtaaca ttgtcagtca 33420

agtttactta aacggagaca aaactaaacc tgtaacacta accattacac taaacggtac 33480 acaggaaaca ggagacacaa ctccaagtgc atactctatg tcattttcat gggactggtc 33540

tggccacaac tacattaatg aaatatttgc cacatcctct tacacttttt catacattgc 33600

ccaagaataa agaatcgttt gtgttatgtt tcaacgtgtt tatttttcaa ttgcagaaaa 33660

tttcaagtca tttttcattc agtagtatag ccccaccacc acatagctta tacagatcac 33720

cgtacctcaa ctttgtataa taaagttgta atcaaactca cagaacccta gtattcaacc 33780 tgccacctcc ctcccaacac acagagtaca cagtcctttc tccccggctg gccttaaaaa 33840

gcatcatatc atgggtaaca gacatattct taggtgttat attccacacg gtttcctgtc 33900

gagccaaacg ctcatcagtg atattaataa actccccggg cagctcactt aagttcatgt 33960 cgctgtccag ctgctgagcc acaggctgct gtccaacttg cggttgctta acgggcggcg 34020

aaggagaagt ccacgcctac atgggggtag agtcataatc gtgcatcagg atagggcggt 34080 ggtgctgcag cagcgcgcga ataaactgct gccgccgccg ctccgtcctg caggaataca 34140 acatggcagt ggtctcctca gcgatgattc gcaccgcccg cagcataagg cgccttgtcc 34200

tccgggcaca gcagcgcacc ctgatctcac ttaaatcagc acagtaactg cagcacagca 34260 ccacaatatt gttcaaaatc ccacagtgca aggcgctgta tccaaagctc atggcgggga 34320 ccacagaacc cacgtggcca tcataccaca agcgcaggta gattaagtgg cgacccctca 34380

taaacacgct ggacataaac attacctctt ttggcatgtt gtaattcacc acctcccggt 34440 accatataaa cctctgatta aacatggcgc catccaccac catcctaaac cagctggcca 34500

aaacctgccc gccggctata cactgcaggg aaccgggact ggaacaatga cagtggagag 34560 cccaggactc gtaaccatgg atcatcatgc tcgtcatgat atcaatgttg gcacaacaca 34620 ggcacacgtg catacacttc ctcaggatta caagctcctc ccgcgttaga accatatccc 34680

agggaacaac ccattcctga atcagcgtaa atcccacact gcagggaaga cctcgcacgt 34740 Page 72

Sequence_Listing.txt aactcacgtt gtgcattgtc aaagtgttac attcgggcag cagcggatga tcctccagta 34800

tggtagcgcg ggtttctgtc tcaaaaggag gtagacgatc cctactgtac ggagtgcgcc 34860 gagacaaccg agatcgtgtt ggtcgtagtg tcatgccaaa tggaacgccg gacgtagtca 34920

tatttcctga agcaaaacca ggtgcgggcg tgacaaacag atctgcgtct ccggtctcgc 34980 cgcttagatc gctctgtgta gtagttgtag tatatccact ctctcaaagc atccaggcgc 35040 cccctggctt cgggttctat gtaaactcct tcatgcgccg ctgccctgat aacatccacc 35100

accgcagaat aagccacacc cagccaacct acacattcgt tctgcgagtc acacacggga 35160 ggagcgggaa gagctggaag aaccatgttt ttttttttat tccaaaagat tatccaaaac 35220 ctcaaaatga agatctatta agtgaacgcg ctcccctccg gtggcgtggt caaactctac 35280

agccaaagaa cagataatgg catttgtaag atgttgcaca atggcttcca aaaggcaaac 35340 ggccctcacg tccaagtgga cgtaaaggct aaacccttca gggtgaatct cctctataaa 35400 cattccagca ccttcaacca tgcccaaata attctcatct cgccaccttc tcaatatatc 35460

tctaagcaaa tcccgaatat taagtccggc cattgtaaaa atctgctcca gagcgccctc 35520 caccttcagc ctcaagcagc gaatcatgat tgcaaaaatt caggttcctc acagacctgt 35580

ataagattca aaagcggaac attaacaaaa ataccgcgat cccgtaggtc ccttcgcagg 35640

gccagctgaa cataatcgtg caggtctgca cggaccagcg cggccacttc cccgccagga 35700

accatgacaa aagaacccac actgattatg acacgcatac tcggagctat gctaaccagc 35760

gtagccccga tgtaagcttg ttgcatgggc ggcgatataa aatgcaaggt gctgctcaaa 35820 aaatcaggca aagcctcgcg caaaaaagaa agcacatcgt agtcatgctc atgcagataa 35880

aggcaggtaa gctccggaac caccacagaa aaagacacca tttttctctc aaacatgtct 35940

gcgggtttct gcataaacac aaaataaaat aacaaaaaaa catttaaaca ttagaagcct 36000 gtcttacaac aggaaaaaca acccttataa gcataagacg gactacggcc atgccggcgt 36060

gaccgtaaaa aaactggtca ccgtgattaa aaagcaccac cgacagctcc tcggtcatgt 36120 ccggagtcat aatgtaagac tcggtaaaca catcaggttg attcacatcg gtcagtgcta 36180 aaaagcgacc gaaatagccc gggggaatac atacccgcag gcgtagagac aacattacag 36240

cccccatagg aggtataaca aaattaatag gagagaaaaa cacataaaca cctgaaaaac 36300 cctcctgcct aggcaaaata gcaccctccc gctccagaac aacatacagc gcttccacag 36360 cggcagccat aacagtcagc cttaccagta aaaaagaaaa cctattaaaa aaacaccact 36420

cgacacggca ccagctcaat cagtcacagt gtaaaaaagg gccaagtgca gagcgagtat 36480 atataggact aaaaaatgac gtaacggtta aagtccacaa aaaacaccca gaaaaccgca 36540

cgcgaaccta cgcccagaaa cgaaagccaa aaaacccaca acttcctcaa atcgtcactt 36600 ccgttttccc acgttacgtc acttcccatt ttaagaaaac tacaattccc aacacataca 36660 agttactccg ccctaaaacc tacgtcaccc gccccgttcc cacgccccgc gccacgtcac 36720

aaactccacc ccctcattat catattggct tcaatccaaa ataaggtata ttattgatga 36780 Page 73

Sequence_Listing.txt tg 36782

<210> 5 <211> 36794 <212> DNA <213> Artificial Sequence <220> <223> Synthetic adenovirus genome YPet-P2A-(DNA Poly)

<400> 5 catcatcaat aatatacctt attttggatt gaagccaata tgataatgag ggggtggagt 60 ttgtgacgtg gcgcggggcg tgggaacggg gcgggtgacg tagtagtgtg gcggaagtgt 120 gatgttgcaa gtgtggcgga acacatgtaa gcgacggatg tggcaaaagt gacgtttttg 180

gtgtgcgccg gtgtacacag gaagtgacaa ttttcgcgcg gttttaggcg gatgttgtag 240 taaatttggg cgtaaccgag taagatttgg ccattttcgc gggaaaactg aataagagga 300 agtgaaatct gaataatttt gtgttactca tagcgcgtaa tatttgtcta gggccgcggg 360

gactttgacc gtttacgtgg agactcgccc aggtgttttt ctcaggtgtt ttccgcgttc 420 cgggtcaaag ttggcgtttt attattatag tcagctgacg tgtagtgtat ttatacccgg 480

tgagttcctc aagaggccac tcttgagtgc cagcgagtag agttttctcc tccgagccgc 540

tccgacaccg ggactgaaaa tgagacatat tatctgccac ggaggtgtta ttaccgaaga 600

aatggccgcc agtcttttgg accagctgat cgaagaggta ctggctgata atcttccacc 660

tcctagccat tttgaaccac ctacccttca cgaactgtat gatttagacg tgacggcccc 720 cgaagatccc aacgaggagg cggtttcgca gatttttccc gactctgtaa tgttggcggt 780

gcaggaaggg attgacttac tcacttttcc gccggcgccc ggttctccgg agccgcctca 840

cctttcccgg cagcccgagc agccggagca gagagccttg ggtccggttt ctatgccaaa 900 ccttgtaccg gaggtgatcg atcttacctg ccacgaggct ggctttccac ccagtgacga 960

cgaggatgaa gagggtgagg agtttgtgtt agattatgtg gagcaccccg ggcacggttg 1020 caggtcttgt cattatcacc ggaggaatac gggggaccca gatattatgt gttcgctttg 1080 ctatatgagg acctgtggca tgtttgtcta cagtaagtga aaattatggg cagtgggtga 1140

tagagtggtg ggtttggtgt ggtaattttt tttttaattt ttacagtttt gtggtttaaa 1200 gaattttgta ttgtgatttt tttaaaaggt cctgtgtctg aacctgagcc tgagcccgag 1260 ccagaaccgg agcctgcaag acctacccgc cgtcctaaaa tggcgcctgc tatcctgaga 1320

cgcccgacat cacctgtgtc tagagaatgc aatagtagta cggatagctg tgactccggt 1380 ccttctaaca cacctcctga gatacacccg gtggtcccgc tgtgccccat taaaccagtt 1440

gccgtgagag ttggtgggcg tcgccaggct gtggaatgta tcgaggactt gcttaacgag 1500 cctgggcaac ctttggactt gagctgtaaa cgccccaggc cataaggtgt aaacctgtga 1560 ttgcgtgtgt ggttaacgcc tttgtttgct gaatgagttg atgtaagttt aataaagggt 1620

gagataatgt ttaacttgca tggcgtgtta aatggggcgg ggcttaaagg gtatataatg 1680 Page 74

Sequence_Listing.txt cgccgtgggc taatcttggt tacatctgac ctcatggagg cttgggagtg tttggaagat 1740

ttttctgctg tgcgtaactt gctggaacag agctctaaca gtacctcttg gttttggagg 1800 tttctgtggg gctcatccca ggcaaagtta gtctgcagaa ttaaggagga ttacaagtgg 1860

gaatttgaag agcttttgaa atcctgtggt gagctgtttg attctttgaa tctgggtcac 1920 caggcgcttt tccaagagaa ggtcatcaag actttggatt tttccacacc ggggcgcgct 1980 gcggctgctg ttgctttttt gagttttata aaggataaat ggagcgaaga aacccatctg 2040

agcggggggt acctgctgga ttttctggcc atgcatctgt ggagagcggt tgtgagacac 2100 aagaatcgcc tgctactgtt gtcttccgtc cgcccggcga taataccgac ggaggagcag 2160 cagcagcagc aggaggaagc caggcggcgg cggcaggagc agagcccatg gaacccgaga 2220

gccggcctgg accctcggga atgaatgttg tacaggtggc tgaactgtat ccagaactga 2280 gacgcatttt gacaattaca gaggatgggc aggggctaaa gggggtaaag agggagcggg 2340 gggcttgtga ggctacagag gaggctagga atctagcttt tagcttaatg accagacacc 2400

gtcctgagtg tattactttt caacagatca aggataattg cgctaatgag cttgatctgc 2460 tggcgcagaa gtattccata gagcagctga ccacttactg gctgcagcca ggggatgatt 2520

ttgaggaggc tattagggta tatgcaaagg tggcacttag gccagattgc aagtacaaga 2580

tcagcaaact tgtaaatatc aggaattgtt gctacatttc tgggaacggg gccgaggtgg 2640

agatagatac ggaggatagg gtggccttta gatgtagcat gataaatatg tggccggggg 2700

tgcttggcat ggacggggtg gttattatga atgtaaggtt tactggcccc aattttagcg 2760 gtacggtttt cctggccaat accaacctta tcctacacgg tgtaagcttc tatgggttta 2820

acaatacctg tgtggaagcc tggaccgatg taagggttcg gggctgtgcc ttttactgct 2880

gctggaaggg ggtggtgtgt cgccccaaaa gcagggcttc aattaagaaa tgcctctttg 2940 aaaggtgtac cttgggtatc ctgtctgagg gtaactccag ggtgcgccac aatgtggcct 3000

ccgactgtgg ttgcttcatg ctagtgaaaa gcgtggctgt gattaagcat aacatggtat 3060 gtggcaactg cgaggacagg gcctctcaga tgctgacctg ctcggacggc aactgtcacc 3120 tgctgaagac cattcacgta gccagccact ctcgcaaggc ctggccagtg tttgagcata 3180

acatactgac ccgctgttcc ttgcatttgg gtaacaggag gggggtgttc ctaccttacc 3240 aatgcaattt gagtcacact aagatattgc ttgagcccga gagcatgtcc aaggtgaacc 3300 tgaacggggt gtttgacatg accatgaaga tctggaaggt gctgaggtac gatgagaccc 3360

gcaccaggtg cagaccctgc gagtgtggcg gtaaacatat taggaaccag cctgtgatgc 3420 tggatgtgac cgaggagctg aggcccgatc acttggtgct ggcctgcacc cgcgctgagt 3480

ttggctctag cgatgaagat acagattgag gtactgaaat gtgtgggcgt ggcttaaggg 3540 tgggaaagaa tatataaggt gggggtctta tgtagttttg tatctgtttt gcagcagccg 3600 ccgccgccca acttttctat acaaagttgt aatgagcacc aactcgtttg atggaagcat 3660

tgtgagctca tatttgacaa cgcgcatgcc cccatgggcc ggggtgcgtc agaatgtgat 3720 Page 75

Sequence_Listing.txt gggctccagc attgatggtc gccccgtcct gcccgcaaac tctactacct tgacctacga 3780

gaccgtgtct ggaacgccgt tggagactgc agcctccgcc gccgcttcag ccgctgcagc 3840 caccgcccgc gggattgtga ctgactttgc tttcctgagc ccgcttgcaa gcagtgcagc 3900

ttcccgttca tccgcccgcg atgacaagtt gacggctctt ttggcacaat tggattcttt 3960 gacccgggaa cttaatgtcg tttctcagca gctgttggat ctgcgccagc aggtttctgc 4020 cctgaaggct tcctcccctc ccaatgcggt ttaaaacata aataaaaaac cagactctgt 4080

ttggatttgg atcaagcata agtgtcttgc tgtctttatt taggggtttt gcgcgcgcgg 4140 taggcccggg accagcggtc tcggtcgttg agggtcctgt gtattttttc caggacgtgg 4200 taaaggtgac tctggatgtt cagatacatg ggcataagcc cgtctctggg gtggaggtag 4260

caccactgca gagcttcatg ctgcggggtg gtgttgtaga tgatccagtc gtagcaggag 4320 cgctgggcgt ggtgcctaaa aatgtctttc agtagcaagc tgattgccag gggcaggccc 4380 ttggtgtaag tgtttacaaa gcggttaagc tgggatgggt gcatacgtgg ggatatgaga 4440

tgcatcttgg actgtatttt taggttggct atgttcccag ccatatccct ccggggattc 4500 atgttgtgca gaaccaccag cacagtgtat ccggtgcact tgggaaattt gtcatgtagc 4560

ttagaaggaa atgcgtggaa gaacttggag acgcccttgt gacctccaag attttccatg 4620

cattcgtcca taatgatggc aatgggccca cgggcggcgg cctgggcgaa gatatttctg 4680

ggatcactaa cgtcatagtt gtgttccagg atgagatcgt cataggccat ttttacaaag 4740

cgcgggcgga gggtgccaga ctgcggtata atggttccat ccggcccagg ggcgtagtta 4800 ccctcacaga tttgcatttc ccacgctttg agttcagatg gggggatcat gtctacctgc 4860

ggggcgatga agaaaacggt ttccggggta ggggagatca gctgggaaga aagcaggttc 4920

ctgagcagct gcgacttacc gcagccggtg ggcccgtaaa tcacacctat taccgggtgc 4980 aactggtagt taagagagct gcagctgccg tcatccctga gcaggggggc cacttcgtta 5040

agcatgtccc tgactcgcat gttttccctg accaaatccg ccagaaggcg ctcgccgccc 5100 agcgatagca gttcttgcaa ggaagcaaag tttttcaacg gtttgagacc gtccgccgta 5160 ggcatgcttt tgagcgtttg accaagcagt tccaggcggt cccacagctc ggtcacctgc 5220

tctacggcat ctcgatccag catatctcct cgtttcgcgg gttggggcgg ctttcgctgt 5280 acggcagtag tcggtgctcg tccagacggg ccagggtcat gtctttccac gggcgcaggg 5340 tcctcgtcag cgtagtctgg gtcacggtga aggggtgcgc tccgggctgc gcgctggcca 5400

gggtgcgctt gaggctggtc ctgctggtgc tgaagcgctg ccggtcttcg ccctgcgcgt 5460 cggccaggta gcatttgacc atggtgtcat agtccagccc ctccgcggcg tggcccttgg 5520

cgcgcagctt gcccttggag gaggcgccgc acgaggggca gtgcagactt ttgagggcgt 5580 agagcttggg cgcgagaaat accgattccg gggagtaggc atccgcgccg caggccccgc 5640 agacggtctc gcattccacg agccaggtga gctctggccg ttcggggtca aaaaccaggt 5700

ttcccccatg ctttttgatg cgtttcttac ctctggtttc catgagccgg tgtccacgct 5760 Page 76

Sequence_Listing.txt cggtgacgaa aaggctgtcc gtgtccccgt atacagactt gagaggcctg tcctcgagcg 5820

gtgttccgcg gtcctcctcg tatagaaact cggaccactc tgagacaaag gctcgcgtcc 5880 aggccagcac gaaggaggct aagtgggagg ggtagcggtc gttgtccact agggggtcca 5940

ctcgctccag ggtgtgaaga cacatgtcgc cctcttcggc atcaaggaag gtgattggtt 6000 tgtaggtgta ggccacgtga ccgggtgttc ctgaaggggg gctataaaag ggggtggggg 6060 cgcgttcgtc ctcactctct tccgcatcgc tgtctgcgag ggccagctgt tggggtgagt 6120

actccctctg aaaagcgggc atgacttctg cgctaagatt gtcagtttcc aaaaacgagg 6180 aggatttgat attcacctgg cccgcggtga tgcctttgag ggtggccgca tccatctggt 6240 cagaaaagac aatctttttg ttgtcaagct tggtggcaaa cgacccgtag agggcgttgg 6300

acagcaactt ggcgatggag cgcagggttt ggtttttgtc gcgatcggcg cgctccttgg 6360 ccgcgatgtt tagctgcacg tattcgcgcg caacgcaccg ccattcggga aagacggtgg 6420 tgcgctcgtc gggcaccagg tgcacgcgcc aaccgcggtt gtgcagggtg acaaggtcaa 6480

cgctggtggc tacctctccg cgtaggcgct cgttggtcca gcagaggcgg ccgcccttgc 6540 gcgagcagaa tggcggtagg gggtctagct gcgtctcgtc cggggggtct gcgtccacgg 6600

taaagacccc gggcagcagg cgcgcgtcga agtagtctat cttgcatcct tgcaagtcta 6660

gcgcctgctg ccatgcgcgg gcggcaagcg cgcgctcgta tgggttgagt gggggacccc 6720

atggcatggg gtgggtgagc gcggaggcgt acatgccgca aatgtcgtaa acgtagaggg 6780

gctctctgag tattccaaga tatgtagggt agcatcttcc accgcggatg ctggcgcgca 6840 cgtaatcgta tagttcgtgc gagggagcga ggaggtcggg accgaggttg ctacgggcgg 6900

gctgctctgc tcggaagact atctgcctga agatggcatg tgagttggat gatatggttg 6960

gacgctggaa gacgttgaag ctggcgtctg tgagacctac cgcgtcacgc acgaaggagg 7020 cgtaggagtc gcgcagcttg ttgaccagct cggcggtgac ctgcacgtct agggcgcagt 7080

agtccagggt ttccttgatg atgtcatact tatcctgtcc cttttttttc cacagctcgc 7140 ggttgaggac aaactcttcg cggtctttcc agtactcttg gatcggaaac ccgtcggcct 7200 ccgaacggta agagcctagc atgtagaact ggttgacggc ctggtaggcg cagcatccct 7260

tttctacggg tagcgcgtat gcctgcgcgg ccttccggag cgaggtgtgg gtgagcgcaa 7320 aggtgtccct gaccatgact ttgaggtact ggtatttgaa gtcagtgtcg tcgcatccgc 7380 cctgctccca gagcaaaaag tccgtgcgct ttttggaacg cggatttggc agggcgaagg 7440

tgacatcgtt gaagagtatc tttcccgcgc gaggcataaa gttgcgtgtg atgcggaagg 7500 gtcccggcac ctcggaacgg ttgttaatta cctgggcggc gagcacgatc tcgtcaaagc 7560

cgttgatgtt gtggcccaca atgtaaagtt ccaagaagcg cgggatgccc ttgatggaag 7620 gcaatttttt aagttcctcg taggtgagct cttcagggga gctgagcccg tgctctgaaa 7680 gggcccagtc tgcaagatga gggttggaag cgacgaatga gctccacagg tcacgggcca 7740

ttagcatttg caggtggtcg cgaaaggtcc taaactggcg acctatggcc attttttctg 7800 Page 77

Sequence_Listing.txt gggtgatgca gtagaaggta agcgggtctt gttcccagcg gtcccatcca aggttcgcgg 7860

ctaggtctcg cgcggcagtc actagaggct catctccgcc gaacttcatg accagcatga 7920 agggcacgag ctgcttccca aaggccccca tccaagtata ggtctctaca tcgtaggtga 7980

caaagagacg ctcggtgcga ggatgcgagc cgatcgggaa gaactggatc tcccgccacc 8040 aattggagga gtggctattg atgtggtgaa agtagaagtc cctgcgacgg gccgaacact 8100 cgtgctggct tttgtaaaaa cgtgcgcagt actggcagcg gtgcacgggc tgtacatcct 8160

gcacgaggtt gacctgacga ccgcgcacaa ggaagcagag tgggaatttg agcccctcgc 8220 ctggcgggtt tggctggtgg tcttctactt cggctgcttg tccttgaccg tctggctgct 8280 cgaggggagt tacggtggat cggaccacca cgccgcgcga gcccaaagtc cagatgtccg 8340

cgcgcggcgg tcggagcttg atgacaacat cgcgcagatg ggagctgtcc atggtctgga 8400 gctcccgcgg cgtcaggtca ggcgggagct cctgcaggtt tacctcgcat agacgggtca 8460 gggcgcgggc tagatccagg tgatacctaa tttccagggg ctggttggtg gcggcgtcga 8520

tggcttgcaa gaggccgcat ccccgcggcg cgactacggt accgcgcggc gggcggtggg 8580 ccgcgggggt gtccttggat gatgcatcta aaagcggtga cgcgggcgag cccccggagg 8640

tagggggggc tccggacccg ccgggagagg gggcaggggc acgtcggcgc cgcgcgcggg 8700

caggagctgg tgctgcgcgc gtaggttgct ggcgaacgcg acgacgcggc ggttgatctc 8760

ctgaatctgg cgcctctgcg tgaagacgac gggcccggtg agcttgagcc tgaaagagag 8820

ttcgacagaa tcaatttcgg tgtcgttgac ggcggcctgg cgcaaaatct cctgcacgtc 8880 tcctgagttg tcttgatagg cgatctcggc catgaactgc tcgatctctt cctcctggag 8940

atctccgcgt ccggctcgct ccacggtggc ggcgaggtcg ttggaaatgc gggccatgag 9000

ctgcgagaag gcgttgaggc ctccctcgtt ccagacgcgg ctgtagacca cgcccccttc 9060 ggcatcgcgg gcgcgcatga ccacctgcgc gagattgagc tccacgtgcc gggcgaagac 9120

ggcgtagttt cgcaggcgct gaaagaggta gttgagggtg gtggcggtgt gttctgccac 9180 gaagaagtac ataacccagc gtcgcaacgt ggattcgttg atatccccca aggcctcaag 9240 gcgctccatg gcctcgtaga agtccacggc gaagttgaaa aactgggagt tgcgcgccga 9300

cacggttaac tcctcctcca gaagacggat gagctcggcg acagtgtcgc gcacctcgcg 9360 ctcaaaggct acaggggcct cttcttcttc ttcaatctcc tcttccataa gggcctcccc 9420 ttcttcttct tctggcggcg gtgggggagg ggggacacgg cggcgacgac ggcgcaccgg 9480

gaggcggtcg acaaagcgct cgatcatctc cccgcggcga cggcgcatgg tctcggtgac 9540 ggcgcggccg ttctcgcggg ggcgcagttg gaagacgccg cccgtcatgt cccggttatg 9600

ggttggcggg gggctgccat gcggcaggga tacggcgcta acgatgcatc tcaacaattg 9660 ttgtgtaggt actccgccgc cgagggacct gagcgagtcc gcatcgaccg gatcggaaaa 9720 cctctcgaga aaggcgtcta accagtcaca gtcgcaaggt aggctgagca ccgtggcggg 9780

cggcagcggg cggcggtcgg ggttgtttct ggcggaggtg ctgctgatga tgtaattaaa 9840 Page 78

Sequence_Listing.txt gtaggcggtc ttgagacggc ggatggtcga cagaagcacc atgtccttgg gtccggcctg 9900

ctgaatgcgc aggcggtcgg ccatgcccca ggcttcgttt tgacatcggc gcaggtcttt 9960 gtagtagtct tgcatgagcc tttctaccgg cacttcttct tctccttcct cttgtcctgc 10020

atctcttgca tctatcgctg cggcggcggc ggagtttggc cgtaggtggc gccctcttcc 10080 tcccatgcgt gtgaccccga agcccctcat cggctgaagc agggctaggt cggcgacaac 10140 gcgctcggct aatatggcct gctgcacctg cgtgagggta gactggaagt catccatgtc 10200

cacaaagcgg tggtatgcgc ccgtgttgat ggtgtaagtg cagttggcca taacggacca 10260 gttaacggtc tggtgacccg gctgcgagag ctcggtgtac ctgagacgcg agtaagccct 10320 cgagtcaaat acgtagtcgt tgcaagtccg caccaggtac tggtatccca ccaaaaagtg 10380

cggcggcggc tggcggtaga ggggccagcg tagggtggcc ggggctccgg gggcgagatc 10440 ttccaacata aggcgatgat atccgtagat gtacctggac atccaggtga tgccggcggc 10500 ggtggtggag gcgcgcggaa agtcgcggac gcggttccag atgttgcgca gcggcaaaaa 10560

gtgctccatg gtcgggacgc tctggccggt caggcgcgcg caatcgttga cgctctagac 10620 cgtgcaaaag gagagcctgt aagcgggcac tcttccgtgg tctggtggat aaattcgcaa 10680

gggtatcatg gcggacgacc ggggttcgag ccccgtatcc ggccgtccgc cgtgatccat 10740

gcggttaccg cccgcgtgtc gaacccaggt gtgcgacgtc agacaacggg ggagtgctcc 10800

ttttggcttc cttccaggcg cggcggctgc tgcgctagct tttttggcca ctggccgcgc 10860

gcagcgtaag cggttaggct ggaaagcgaa agcattaagt ggctcgctcc ctgtagccgg 10920 agggttattt tccaagggtt gagtcgcggg acccccggtt cgagtctcgg accggccgga 10980

ctgcggcgaa cgggggtttg cctccccgtc atgcaagacc ccgcttgcaa attcctccgg 11040

aaacagggac gagccccttt tttgcttttc ccagatgcat ccggtgctgc ggcagatgcg 11100 cccccctcct cagcagcggc aagagcaaga gcagcggcag acatgcaggg caccctcccc 11160

tcctcctacc gcgtcaggag gggcgacatc cgcggttgac gcggcagcag atggtgatta 11220 cgaacccccg cggcgccggg cccggcacta cctggacttg gaggagggcg agggcctggc 11280 gcggctagga gcgccctctc ctgagcggca cccaagggtg cagctgaagc gtgatacgcg 11340

tgaggcgtac gtgccgcggc agaacctgtt tcgcgaccgc gagggagagg agcccgagga 11400 gatgcgggat cgaaagttcc acgcagggcg cgagctgcgg catggcctga atcgcgagcg 11460 gttgctgcgc gaggaggact ttgagcccga cgcgcgaacc gggattagtc ccgcgcgcgc 11520

acacgtggcg gccgccgacc tggtaaccgc atacgagcag acggtgaacc aggagattaa 11580 ctttcaaaaa agctttaaca accacgtgcg tacgcttgtg gcgcgcgagg aggtggctat 11640

aggactgatg catctgtggg actttgtaag cgcgctggag caaaacccaa atagcaagcc 11700 gctcatggcg cagctgttcc ttatagtgca gcacagcagg gacaacgagg cattcaggga 11760 tgcgctgcta aacatagtag agcccgaggg ccgctggctg ctcgatttga taaacatcct 11820

gcagagcata gtggtgcagg agcgcagctt gagcctggct gacaaggtgg ccgccatcaa 11880 Page 79

Sequence_Listing.txt ctattccatg cttagcctgg gcaagtttta cgcccgcaag atataccata ccccttacgt 11940

tcccatagac aaggaggtaa agatcgaggg gttctacatg cgcatggcgc tgaaggtgct 12000 taccttgagc gacgacctgg gcgtttatcg caacgagcgc atccacaagg ccgtgagcgt 12060

gagccggcgg cgcgagctca gcgaccgcga gctgatgcac agcctgcaaa gggccctggc 12120 tggcacgggc agcggcgata gagaggccga gtcctacttt gacgcgggcg ctgacctgcg 12180 ctgggcccca agccgacgcg ccctggaggc agctggggcc ggacctgggc tggcggtggc 12240

acccgcgcgc gctggcaacg tcggcggcgt ggaggaatat gacgaggacg atgagtacga 12300 gccagaggac ggcgagtact aagcggtgat gtttctgatc agatgatgca agacgcaacg 12360 gacccggcgg tgcgggcggc gctgcagagc cagccgtccg gccttaactc cacggacgac 12420

tggcgccagg tcatggaccg catcatgtcg ctgactgcgc gcaatcctga cgcgttccgg 12480 cagcagccgc aggccaaccg gctctccgca attctggaag cggtggtccc ggcgcgcgca 12540 aaccccacgc acgagaaggt gctggcgatc gtaaacgcgc tggccgaaaa cagggccatc 12600

cggcccgacg aggccggcct ggtctacgac gcgctgcttc agcgcgtggc tcgttacaac 12660 agcggcaacg tgcagaccaa cctggaccgg ctggtggggg atgtgcgcga ggccgtggcg 12720

cagcgtgagc gcgcgcagca gcagggcaac ctgggctcca tggttgcact aaacgccttc 12780

ctgagtacac agcccgccaa cgtgccgcgg ggacaggagg actacaccaa ctttgtgagc 12840

gcactgcggc taatggtgac tgagacaccg caaagtgagg tgtaccagtc tgggccagac 12900

tattttttcc agaccagtag acaaggcctg cagaccgtaa acctgagcca ggctttcaaa 12960 aacttgcagg ggctgtgggg ggtgcgggct cccacaggcg accgcgcgac cgtgtctagc 13020

ttgctgacgc ccaactcgcg cctgttgctg ctgctaatag cgcccttcac ggacagtggc 13080

agcgtgtccc gggacacata cctaggtcac ttgctgacac tgtaccgcga ggccataggt 13140 caggcgcatg tggacgagca tactttccag gagattacaa gtgtcagccg cgcgctgggg 13200

caggaggaca cgggcagcct ggaggcaacc ctaaactacc tgctgaccaa ccggcggcag 13260 aagatcccct cgttgcacag tttaaacagc gaggaggagc gcattttgcg ctacgtgcag 13320 cagagcgtga gccttaacct gatgcgcgac ggggtaacgc ccagcgtggc gctggacatg 13380

accgcgcgca acatggaacc gggcatgtat gcctcaaacc ggccgtttat caaccgccta 13440 atggactact tgcatcgcgc ggccgccgtg aaccccgagt atttcaccaa tgccatcttg 13500 aacccgcact ggctaccgcc ccctggtttc tacaccgggg gattcgaggt gcccgagggt 13560

aacgatggat tcctctggga cgacatagac gacagcgtgt tttccccgca accgcagacc 13620 ctgctagagt tgcaacagcg cgagcaggca gaggcggcgc tgcgaaagga aagcttccgc 13680

aggccaagca gcttgtccga tctaggcgct gcggccccgc ggtcagatgc tagtagccca 13740 tttccaagct tgatagggtc tcttaccagc actcgcacca cccgcccgcg cctgctgggc 13800 gaggaggagt acctaaacaa ctcgctgctg cagccgcagc gcgaaaaaaa cctgcctccg 13860

gcatttccca acaacgggat agagagccta gtggacaaga tgagtagatg gaagacgtac 13920 Page 80

Sequence_Listing.txt gcgcaggagc acagggacgt gccaggcccg cgcccgccca cccgtcgtca aaggcacgac 13980

cgtcagcggg gtctggtgtg ggaggacgat gactcggcag acgacagcag cgtcctggat 14040 ttgggaggga gtggcaaccc gtttgcgcac cttcgcccca ggctggggag aatgttttaa 14100

aaaaaaaaaa aaagcatgat gcaaaataaa aaactcacca aggccattgg gccaggattc 14160 tcctcgacgt caccagcctg cttcagcagg ctgaagttag tagctccgct tcccttatag 14220 agctcgttca tgccctcggt gatgccggcg gcggtcagga actccagcag caccatgtgg 14280

tcccgcttct cgttggggtc cttgaacagg gcgctctggt agctcaggta gtggttgtcg 14340 ggcagcagca cggggccgtc gccgatgggg gtgttctgct ggtagtggtc ggccagctgc 14400 acgccgccgt cctcgatgtt gtgccggatc ttgaagttgg ccttgatgcc gttcttctgc 14460

ttgtcggcgg tgatgtacac gttgtggctg ttgtagttgt actccagctt gtggcccagg 14520 atgttgccgt cctccttgaa gtcgatgccc ttcagctcga tccggttcac cagggtgtcg 14580 ccctcgaact tcacctcggc ccgggtcttg tagttgccgt cgtccttgaa gaagatggtc 14640

cgctcctgca cgtagccctc gggcatggcg ctcttgaaga agtcgtgctg cttcatgtgg 14700 tcggggtacc gggcgaagca ctgcacgccg tagcccaggg tggtcaccag ggtgggccag 14760

ggcacgggca gcttgccggt ggtgcacagc agcttcaggg tcagcttgcc gtaggtggcg 14820

tcgccctcgc cctcgccgct cacgctgaac ttgtggccgt tcacgtcgcc gtccagctcc 14880

accaggatgg gcaccacgcc ggtgaacagc tcttcgcctt tgctcaccat ggcaccgagc 14940

gttggttttc ttgtattccc cttagtatgc ggcgcgcggc gatgtatgag gaaggtcctc 15000 ctccctccta cgagagtgtg gtgagcgcgg cgccagtggc ggcggcgctg ggttctccct 15060

tcgatgctcc cctggacccg ccgtttgtgc ctccgcggta cctgcggcct accgggggga 15120

gaaacagcat ccgttactct gagttggcac ccctattcga caccacccgt gtgtacctgg 15180 tggacaacaa gtcaacggat gtggcatccc tgaactacca gaacgaccac agcaactttc 15240

tgaccacggt cattcaaaac aatgactaca gcccggggga ggcaagcaca cagaccatca 15300 atcttgacga ccggtcgcac tggggcggcg acctgaaaac catcctgcat accaacatgc 15360 caaatgtgaa cgagttcatg tttaccaata agtttaaggc gcgggtgatg gtgtcgcgct 15420

tgcctactaa ggacaatcag gtggagctga aatacgagtg ggtggagttc acgctgcccg 15480 agggcaacta ctccgagacc atgaccatag accttatgaa caacgcgatc gtggagcact 15540 acttgaaagt gggcagacag aacggggttc tggaaagcga catcggggta aagtttgaca 15600

cccgcaactt cagactgggg tttgaccccg tcactggtct tgtcatgcct ggggtatata 15660 caaacgaagc cttccatcca gacatcattt tgctgccagg atgcggggtg gacttcaccc 15720

acagccgcct gagcaacttg ttgggcatcc gcaagcggca acccttccag gagggcttta 15780 ggatcaccta cgatgatctg gagggtggta acattcccgc actgttggat gtggacgcct 15840 accaggcgag cttgaaagat gacaccgaac agggcggggg tggcgcaggc ggcagcaaca 15900

gcagtggcag cggcgcggaa gagaactcca acgcggcagc cgcggcaatg cagccggtgg 15960 Page 81

Sequence_Listing.txt aggacatgaa cgatcatgcc attcgcggcg acacctttgc cacacgggct gaggagaagc 16020

gcgctgaggc cgaagcagcg gccgaagctg ccgcccccgc tgcgcaaccc gaggtcgaga 16080 agcctcagaa gaaaccggtg atcaaacccc tgacagagga cagcaagaaa cgcagttaca 16140

acctaataag caatgacagc accttcaccc agtaccgcag ctggtacctt gcatacaact 16200 acggcgaccc tcagaccgga atccgctcat ggaccctgct ttgcactcct gacgtaacct 16260 gcggctcgga gcaggtctac tggtcgttgc cagacatgat gcaagacccc gtgaccttcc 16320

gctccacgcg ccagatcagc aactttccgg tggtgggcgc cgagctgttg cccgtgcact 16380 ccaagagctt ctacaacgac caggccgtct actcccaact catccgccag tttacctctc 16440 tgacccacgt gttcaatcgc tttcccgaga accagatttt ggcgcgcccg ccagccccca 16500

ccatcaccac cgtcagtgaa aacgttcctg ctctcacaga tcacgggacg ctaccgctgc 16560 gcaacagcat cggaggagtc cagcgagtga ccattactga cgccagacgc cgcacctgcc 16620 cctacgttta caaggccctg ggcatagtct cgccgcgcgt cctatcgagc cgcacttttt 16680

gagcaagcat gtccatcctt atatcgccca gcaataacac aggctggggc ctgcgcttcc 16740 caagcaagat gtttggcggg gccaagaagc gctccgacca acacccagtg cgcgtgcgcg 16800

ggcactaccg cgcgccctgg ggcgcgcaca aacgcggccg cactgggcgc accaccgtcg 16860

atgacgccat cgacgcggtg gtggaggagg cgcgcaacta cacgcccacg ccgccaccag 16920

tgtccacagt ggacgcggcc attcagaccg tggtgcgcgg agcccggcgc tatgctaaaa 16980

tgaagagacg gcggaggcgc gtagcacgtc gccaccgccg ccgacccggc actgccgccc 17040 aacgcgcggc ggcggccctg cttaaccgcg cacgtcgcac cggccgacgg gcggccatgc 17100

gggccgctcg aaggctggcc gcgggtattg tcactgtgcc ccccaggtcc aggcgacgag 17160

cggccgccgc agcagccgcg gccattagtg ctatgactca gggtcgcagg ggcaacgtgt 17220 attgggtgcg cgactcggtt agcggcctgc gcgtgcccgt gcgcacccgc cccccgcgca 17280

actagattgc aagaaaaaac tacttagact cgtactgttg tatgtatcca gcggcggcgg 17340 cgcgcaacga agctatgtcc aagcgcaaaa tcaaagaaga gatgctccag gtcatcgcgc 17400 cggagatcta tggccccccg aagaaggaag agcaggatta caagccccga aagctaaagc 17460

gggtcaaaaa gaaaaagaaa gatgatgatg atgaacttga cgacgaggtg gaactgctgc 17520 acgctaccgc gcccaggcga cgggtacagt ggaaaggtcg acgcgtaaaa cgtgttttgc 17580 gacccggcac caccgtagtc tttacgcccg gtgagcgctc cacccgcacc tacaagcgcg 17640

tgtatgatga ggtgtacggc gacgaggacc tgcttgagca ggccaacgag cgcctcgggg 17700 agtttgccta cggaaagcgg cataaggaca tgctggcgtt gccgctggac gagggcaacc 17760

caacacctag cctaaagccc gtaacactgc agcaggtgct gcccgcgctt gcaccgtccg 17820 aagaaaagcg cggcctaaag cgcgagtctg gtgacttggc acccaccgtg cagctgatgg 17880 tacccaagcg ccagcgactg gaagatgtct tggaaaaaat gaccgtggaa cctgggctgg 17940

agcccgaggt ccgcgtgcgg ccaatcaagc aggtggcgcc gggactgggc gtgcagaccg 18000 Page 82

Sequence_Listing.txt tggacgttca gatacccact accagtagca ccagtattgc caccgccaca gagggcatgg 18060

agacacaaac gtccccggtt gcctcagcgg tggcggatgc cgcggtgcag gcggtcgctg 18120 cggccgcgtc caagacctct acggaggtgc aaacggaccc gtggatgttt cgcgtttcag 18180

ccccccggcg cccgcgccgt tcgaggaagt acggcgccgc cagcgcgcta ctgcccgaat 18240 atgccctaca tccttccatt gcgcctaccc ccggctatcg tggctacacc taccgcccca 18300 gaagacgagc aactacccga cgccgaacca ccactggaac ccgccgccgc cgtcgccgtc 18360

gccagcccgt gctggccccg atttccgtgc gcagggtggc tcgcgaagga ggcaggaccc 18420 tggtgctgcc aacagcgcgc taccacccca gcatcgttta aaagccggtc tttgtggttc 18480 ttgcagatat ggccctcacc tgccgcctcc gtttcccggt gccgggattc cgaggaagaa 18540

tgcaccgtag gaggggcatg gccggccacg gcctgacggg cggcatgcgt cgtgcgcacc 18600 accggcggcg gcgcgcgtcg caccgtcgca tgcgcggcgg tatcctgccc ctccttattc 18660 cactgatcgc cgcggcgatt ggcgccgtgc ccggaattgc atccgtggcc ttgcaggcgc 18720

agagacactg attaaaaaca agttgcatgt ggaaaaatca aaataaaaag tctggactct 18780 cacgctcgct tggtcctgta actattttgt agaatggaag acatcaactt tgcgtctctg 18840

gccccgcgac acggctcgcg cccgttcatg ggaaactggc aagatatcgg caccagcaat 18900

atgagcggtg gcgccttcag ctggggctcg ctgtggagcg gcattaaaaa tttcggttcc 18960

accgttaaga actatggcag caaggcctgg aacagcagca caggccagat gctgagggat 19020

aagttgaaag agcaaaattt ccaacaaaag gtggtagatg gcctggcctc tggcattagc 19080 ggggtggtgg acctggccaa ccaggcagtg caaaataaga ttaacagtaa gcttgatccc 19140

cgccctcccg tagaggagcc tccaccggcc gtggagacag tgtctccaga ggggcgtggc 19200

gaaaagcgtc cgcgccccga cagggaagaa actctggtga cgcaaataga cgagcctccc 19260 tcgtacgagg aggcactaaa gcaaggcctg cccaccaccc gtcccatcgc gcccatggct 19320

accggagtgc tgggccagca cacacccgta acgctggacc tgcctccccc cgccgacacc 19380 cagcagaaac ctgtgctgcc aggcccgacc gccgttgttg taacccgtcc tagccgcgcg 19440 tccctgcgcc gcgccgccag cggtccgcga tcgttgcggc ccgtagccag tggcaactgg 19500

caaagcacac tgaacagcat cgtgggtctg ggggtgcaat ccctgaagcg ccgacgatgc 19560 ttctgaatag ctaacgtgtc gtatgtgtgt catgtatgcg tccatgtcgc cgccagagga 19620 gctgctgagc cgccgcgcgc ccgctttcca agatggctac cccttcgatg atgccgcagt 19680

ggtcttacat gcacatctcg ggccaggacg cctcggagta cctgagcccc gggctggtgc 19740 agtttgcccg cgccaccgag acgtacttca gcctgaataa caagtttaga aaccccacgg 19800

tggcgcctac gcacgacgtg accacagacc ggtcccagcg tttgacgctg cggttcatcc 19860 ctgtggaccg tgaggatact gcgtactcgt acaaggcgcg gttcacccta gctgtgggtg 19920 ataaccgtgt gctggacatg gcttccacgt actttgacat ccgcggcgtg ctggacaggg 19980

gccctacttt taagccctac tctggcactg cctacaacgc cctggctccc aagggtgccc 20040 Page 83

Sequence_Listing.txt caaatccttg cgaatgggat gaagctgcta ctgctcttga aataaaccta gaagaagagg 20100

acgatgacaa cgaagacgaa gtagacgagc aagctgagca gcaaaaaact cacgtatttg 20160 ggcaggcgcc ttattctggt ataaatatta caaaggaggg tattcaaata ggtgtcgaag 20220

gtcaaacacc taaatatgcc gataaaacat ttcaacctga acctcaaata ggagaatctc 20280 agtggtacga aactgaaatt aatcatgcag ctgggagagt ccttaaaaag actaccccaa 20340 tgaaaccatg ttacggttca tatgcaaaac ccacaaatga aaatggaggg caaggcattc 20400

ttgtaaagca acaaaatgga aagctagaaa gtcaagtgga aatgcaattt ttctcaacta 20460 ctgaggcgac cgcaggcaat ggtgataact tgactcctaa agtggtattg tacagtgaag 20520 atgtagatat agaaacccca gacactcata tttcttacat gcccactatt aaggaaggta 20580

actcacgaga actaatgggc caacaatcta tgcccaacag gcctaattac attgctttta 20640 gggacaattt tattggtcta atgtattaca acagcacggg taatatgggt gttctggcgg 20700 gccaagcatc gcagttgaat gctgttgtag atttgcaaga cagaaacaca gagctttcat 20760

accagctttt gcttgattcc attggtgata gaaccaggta cttttctatg tggaatcagg 20820 ctgttgacag ctatgatcca gatgttagaa ttattgaaaa tcatggaact gaagatgaac 20880

ttccaaatta ctgctttcca ctgggaggtg tgattaatac agagactctt accaaggtaa 20940

aacctaaaac aggtcaggaa aatggatggg aaaaagatgc tacagaattt tcagataaaa 21000

atgaaataag agttggaaat aattttgcca tggaaatcaa tctaaatgcc aacctgtgga 21060

gaaatttcct gtactccaac atagcgctgt atttgcccga caagctaaag tacagtcctt 21120 ccaacgtaaa aatttctgat aacccaaaca cctacgacta catgaacaag cgagtggtgg 21180

ctcccgggtt agtggactgc tacattaacc ttggagcacg ctggtccctt gactatatgg 21240

acaacgtcaa cccatttaac caccaccgca atgctggcct gcgctaccgc tcaatgttgc 21300 tgggcaatgg tcgctatgtg cccttccaca tccaggtgcc tcagaagttc tttgccatta 21360

aaaacctcct tctcctgccg ggctcataca cctacgagtg gaacttcagg aaggatgtta 21420 acatggttct gcagagctcc ctaggaaatg acctaagggt tgacggagcc agcattaagt 21480 ttgatagcat ttgcctttac gccaccttct tccccatggc ccacaacacc gcctccacgc 21540

ttgaggccat gcttagaaac gacaccaacg accagtcctt taacgactat ctctccgccg 21600 ccaacatgct ctaccctata cccgccaacg ctaccaacgt gcccatatcc atcccctccc 21660 gcaactgggc ggctttccgc ggctgggcct tcacgcgcct taagactaag gaaaccccat 21720

cactgggctc gggctacgac ccttattaca cctactctgg ctctataccc tacctagatg 21780 gaacctttta cctcaaccac acctttaaga aggtggccat tacctttgac tcttctgtca 21840

gctggcctgg caatgaccgc ctgcttaccc ccaacgagtt tgaaattaag cgctcagttg 21900 acggggaggg ttacaacgtt gcccagtgta acatgaccaa agactggttc ctggtacaaa 21960 tgctagctaa ctacaacatt ggctaccagg gcttctatat cccagagagc tacaaggacc 22020

gcatgtactc cttctttaga aacttccagc ccatgagccg tcaggtggtg gatgatacta 22080 Page 84

Sequence_Listing.txt aatacaagga ctaccaacag gtgggcatcc tacaccaaca caacaactct ggatttgttg 22140

gctaccttgc ccccaccatg cgcgaaggac aggcctaccc tgctaacttc ccctatccgc 22200 ttataggcaa gaccgcagtt gacagcatta cccagaaaaa gtttctttgc gatcgcaccc 22260

tttggcgcat cccattctcc agtaacttta tgtccatggg cgcactcaca gacctgggcc 22320 aaaaccttct ctacgccaac tccgcccacg cgctagacat gacttttgag gtggatccca 22380 tggacgagcc cacccttctt tatgttttgt ttgaagtctt tgacgtggtc cgtgtgcacc 22440

ggccgcaccg cggcgtcatc gaaaccgtgt acctgcgcac gcccttctcg gccggcaacg 22500 ccacaacata aagaagcaag caacatcaac aacagctgcc gccatgggct ccagtgagca 22560 ggaactgaaa gccattgtca aagatcttgg ttgtgggcca tattttttgg gcacctatga 22620

caagcgcttt ccaggctttg tttctccaca caagctcgcc tgcgccatag tcaatacggc 22680 cggtcgcgag actgggggcg tacactggat ggcctttgcc tggaacccgc actcaaaaac 22740 atgctacctc tttgagccct ttggcttttc tgaccagcga ctcaagcagg tttaccagtt 22800

tgagtacgag tcactcctgc gccgtagcgc cattgcttct tcccccgacc gctgtataac 22860 gctggaaaag tccacccaaa gcgtacaggg gcccaactcg gccgcctgtg gactattctg 22920

ctgcatgttt ctccacgcct ttgccaactg gccccaaact cccatggatc acaaccccac 22980

catgaacctt attaccgggg tacccaactc catgctcaac agtccccagg tacagcccac 23040

cctgcgtcgc aaccaggaac agctctacag cttcctggag cgccactcgc cctacttccg 23100

cagccacagt gcgcagatta ggagcgccac ttctttttgt cacttgaaaa acatgtaaaa 23160 ataatgtact agagacactt tcaataaagg caaatgcttt tatttgtaca ctctcgggtg 23220

attatttacc cccacccttg ccgtctgcgc cgtttaaaaa tcaaaggggt tctgccgcgc 23280

atcgctatgc gccactggca gggacacgtt gcgatactgg tgtttagtgc tccacttaaa 23340 ctcaggcaca accatccgcg gcagctcggt gaagttttca ctccacaggc tgcgcaccat 23400

caccaacgcg tttagcaggt cgggcgccga tatcttgaag tcgcagttgg ggcctccgcc 23460 ctgcgcgcgc gagttgcgat acacagggtt gcagcactgg aacactatca gcgccgggtg 23520 gtgcacgctg gccagcacgc tcttgtcgga gatcagatcc gcgtccaggt cctccgcgtt 23580

gctcagggcg aacggagtca actttggtag ctgccttccc aaaaagggcg cgtgcccagg 23640 ctttgagttg cactcgcacc gtagtggcat caaaaggtga ccgtgcccgg tctgggcgtt 23700 aggatacagc gcctgcataa aagccttgat ctgcttaaaa gccacctgag cctttgcgcc 23760

ttcagagaag aacatgccgc aagacttgcc ggaaaactga ttggccggac aggccgcgtc 23820 gtgcacgcag caccttgcgt cggtgttgga gatctgcacc acatttcggc cccaccggtt 23880

cttcacgatc ttggccttgc tagactgctc cttcagcgcg cgctgcccgt tttcgctcgt 23940 cacatccatt tcaatcacgt gctccttatt tatcataatg cttccgtgta gacacttaag 24000 ctcgccttcg atctcagcgc agcggtgcag ccacaacgcg cagcccgtgg gctcgtgatg 24060

cttgtaggtc acctctgcaa acgactgcag gtacgcctgc aggaatcgcc ccatcatcgt 24120 Page 85

Sequence_Listing.txt cacaaaggtc ttgttgctgg tgaaggtcag ctgcaacccg cggtgctcct cgttcagcca 24180

ggtcttgcat acggccgcca gagcttccac ttggtcaggc agtagtttga agttcgcctt 24240 tagatcgtta tccacgtggt acttgtccat cagcgcgcgc gcagcctcca tgcccttctc 24300

ccacgcagac acgatcggca cactcagcgg gttcatcacc gtaatttcac tttccgcttc 24360 gctgggctct tcctcttcct cttgcgtccg cataccacgc gccactgggt cgtcttcatt 24420 cagccgccgc actgtgcgct tacctccttt gccatgcttg attagcaccg gtgggttgct 24480

gaaacccacc atttgtagcg ccacatcttc tctttcttcc tcgctgtcca cgattacctc 24540 tggtgatggc gggcgctcgg gcttgggaga agggcgcttc tttttcttct tgggcgcaat 24600 ggccaaatcc gccgccgagg tcgatggccg cgggctgggt gtgcgcggca ccagcgcgtc 24660

ttgtgatgag tcttcctcgt cctcggactc gatacgccgc ctcatccgct tttttggggg 24720 cgcccgggga ggcggcggcg acggggacgg ggacgacacg tcctccatgg ttgggggacg 24780 tcgcgccgca ccgcgtccgc gctcgggggt ggtttcgcgc tgctcctctt cccgactggc 24840

catttccttc tcctataggc agaaaaagat catggagtca gtcgagaaga aggacagcct 24900 aaccgccccc tctgagttcg ccaccaccgc ctccaccgat gccgccaacg cgcctaccac 24960

cttccccgtc gaggcacccc cgcttgagga ggaggaagtg attatcgagc aggacccagg 25020

ttttgtaagc gaagacgacg aggaccgctc agtaccaaca gaggataaaa agcaagacca 25080

ggacaacgca gaggcaaacg aggaacaagt cgggcggggg gacgaaaggc atggcgacta 25140

cctagatgtg ggagacgacg tgctgttgaa gcatctgcag cgccagtgcg ccattatctg 25200 cgacgcgttg caagagcgca gcgatgtgcc cctcgccata gcggatgtca gccttgccta 25260

cgaacgccac ctattctcac cgcgcgtacc ccccaaacgc caagaaaacg gcacatgcga 25320

gcccaacccg cgcctcaact tctaccccgt atttgccgtg ccagaggtgc ttgccaccta 25380 tcacatcttt ttccaaaact gcaagatacc cctatcctgc cgtgccaacc gcagccgagc 25440

ggacaagcag ctggccttgc ggcagggcgc tgtcatacct gatatcgcct cgctcaacga 25500 agtgccaaaa atctttgagg gtcttggacg cgacgagaag cgcgcggcaa acgctctgca 25560 acaggaaaac agcgaaaatg aaagtcactc tggagtgttg gtggaactcg agggtgacaa 25620

cgcgcgccta gccgtactaa aacgcagcat cgaggtcacc cactttgcct acccggcact 25680 taacctaccc cccaaggtca tgagcacagt catgagtgag ctgatcgtgc gccgtgcgca 25740 gcccctggag agggatgcaa atttgcaaga acaaacagag gagggcctac ccgcagttgg 25800

cgacgagcag ctagcgcgct ggcttcaaac gcgcgagcct gccgacttgg aggagcgacg 25860 caaactaatg atggccgcag tgctcgttac cgtggagctt gagtgcatgc agcggttctt 25920

tgctgacccg gagatgcagc gcaagctaga ggaaacattg cactacacct ttcgacaggg 25980 ctacgtacgc caggcctgca agatctccaa cgtggagctc tgcaacctgg tctcctacct 26040 tggaattttg cacgaaaacc gccttgggca aaacgtgctt cattccacgc tcaagggcga 26100

ggcgcgccgc gactacgtcc gcgactgcgt ttacttattt ctatgctaca cctggcagac 26160 Page 86

Sequence_Listing.txt ggccatgggc gtttggcagc agtgcttgga ggagtgcaac ctcaaggagc tgcagaaact 26220

gctaaagcaa aacttgaagg acctatggac ggccttcaac gagcgctccg tggccgcgca 26280 cctggcggac atcattttcc ccgaacgcct gcttaaaacc ctgcaacagg gtctgccaga 26340

cttcaccagt caaagcatgt tgcagaactt taggaacttt atcctagagc gctcaggaat 26400 cttgcccgcc acctgctgtg cacttcctag cgactttgtg cccattaagt accgcgaatg 26460 ccctccgccg ctttggggcc actgctacct tctgcagcta gccaactacc ttgcctacca 26520

ctctgacata atggaagacg tgagcggtga cggtctactg gagtgtcact gtcgctgcaa 26580 cctatgcacc ccgcaccgct ccctggtttg caattcgcag ctgcttaacg aaagtcaaat 26640 tatcggtacc tttgagctgc agggtccctc gcctgacgaa aagtccgcgg ctccggggtt 26700

gaaactcact ccggggctgt ggacgtcggc ttaccttcgc aaatttgtac ctgaggacta 26760 ccacgcccac gagattaggt tctacgaaga ccaatcccgc ccgccaaatg cggagcttac 26820 cgcctgcgtc attacccagg gccacattct tggccaattg caagccatca acaaagcccg 26880

ccaagagttt ctgctacgaa agggacgggg ggtttacttg gacccccagt ccggcgagga 26940 gctcaaccca atccccccgc cgccgcagcc ctatcagcag cagccgcggg cccttgcttc 27000

ccaggatggc acccaaaaag aagctgcagc tgccgccgcc acccacggac gaggaggaat 27060

actgggacag tcaggcagag gaggttttgg acgaggagga ggaggacatg atggaagact 27120

gggagagcct agacgaggaa gcttccgagg tcgaagaggt gtcagacgaa acaccgtcac 27180

cctcggtcgc attcccctcg ccggcgcccc agaaatcggc aaccggttcc agcatggcta 27240 caacctccgc tcctcaggcg ccgccggcac tgcccgttcg ccgacccaac cgtagatggg 27300

acaccactgg aaccagggcc ggtaagtcca agcagccgcc gccgttagcc caagagcaac 27360

aacagcgcca aggctaccgc tcatggcgcg ggcacaagaa cgccatagtt gcttgcttgc 27420 aagactgtgg gggcaacatc tccttcgccc gccgctttct tctctaccat cacggcgtgg 27480

ccttcccccg taacatcctg cattactacc gtcatctcta cagcccatac tgcaccggcg 27540 gcagcggcag cggcagcaac agcagcggcc acacagaagc aaaggcgacc ggatagcaag 27600 actctgacaa agcccaagaa atccacagcg gcggcagcag caggaggagg agcgctgcgt 27660

ctggcgccca acgaacccgt atcgacccgc gagcttagaa acaggatttt tcccactctg 27720 tatgctatat ttcaacagag caggggccaa gaacaagagc tgaaaataaa aaacaggtct 27780 ctgcgatccc tcacccgcag ctgcctgtat cacaaaagcg aagatcagct tcggcgcacg 27840

ctggaagacg cggaggctct cttcagtaaa tactgcgcgc tgactcttaa ggactagttt 27900 cgcgcccttt ctcaaattta agcgcgaaaa ctacgtcatc tccagcggcc acacccggcg 27960

ccagcacctg tcgtcagcgc catttcaact ttgtatacaa aagttgtgat gagcaaggaa 28020 attcccacgc cctacatgtg gagttaccag ccacaaatgg gacttgcggc tggagctgcc 28080 caagactact caacccgaat aaactacatg agcgcgggac cccacatgat atcccgggtc 28140

aacggaatac gcgcccaccg aaaccgaatt ctcctggaac aggcggctat taccaccaca 28200 Page 87

Sequence_Listing.txt cctcgtaata accttaatcc ccgtagttgg cccgctgccc tggtgtacca ggaaagtccc 28260

gctcccacca ctgtggtact tcccagagac gcccaggccg aagttcagat gactaactca 28320 ggggcgcagc ttgcgggcgg ctttcgtcac agggtgcggt cgcccgggca gggtataact 28380

cacctgacaa tcagagggcg aggtattcag ctcaacgacg agtcggtgag ctcctcgctt 28440 ggtctccgtc cggacgggac atttcagatc ggcggcgccg gccgctcttc attcacgcct 28500 cgtcaggcaa tcctaactct gcagacctcg tcctctgagc cgcgctctgg aggcattgga 28560

actctgcaat ttattgagga gtttgtgcca tcggtctact ttaacccctt ctcgggacct 28620 cccggccact atccggatca atttattcct aactttgacg cggtaaagga ctcggcggac 28680 ggctacgact gaatgttaag tggagaggca gagcaactgc gcctgaaaca cctggtccac 28740

tgtcgccgcc acaagtgctt tgcccgcgac tccggtgagt tttgctactt tgaattgccc 28800 gaggatcata tcgagggccc ggcgcacggc gtccggctta ccgcccaggg agagcttgcc 28860 cgtagcctga ttcgggagtt tacccagcgc cccctgctag ttgagcggga caggggaccc 28920

tgtgttctca ctgtgatttg caactgtcct aaccctggat tacatcaaga tctttgttgc 28980 catctctgtg ctgagtataa taaatacaga aattaaaata tactggggct cctatcgcca 29040

tcctgtaaac gccaccgtct tcacccgccc aagcaaacca aggcgaacct tacctggtac 29100

ttttaacatc tctccctctg tgatttacaa cagtttcaac ccagacggag tgagtctacg 29160

agagaacctc tccgagctca gctactccat cagaaaaaac accaccctcc ttacctgccg 29220

ggaacgtacg agtgcgtcac cggccgctgc accacaccta ccgcctgacc gtaaaccaga 29280 ctttttccgg acagacctca ataactctgt ttaccagaac aggaggtgag cttagaaaac 29340

ccttagggta ttaggccaaa ggcgcagcta ctgtggggtt tatgaacaat tcaagcaact 29400

ctacgggcta ttctaattca ggtttctcta gaatcggggt tggggttatt ctctgtcttg 29460 tgattctctt tattcttata ctaacgcttc tctgcctaag gctcgccgcc tgctgtgtgc 29520

acatttgcat ttattgtcag ctttttaaac gctggggtcg ccacccaaga tgattaggta 29580 cataatccta ggtttactca cccttgcgtc agcccacggt accacccaaa aggtggattt 29640 taaggagcca gcctgtaatg ttacattcgc agctgaagct aatgagtgca ccactcttat 29700

aaaatgcacc acagaacatg aaaagctgct tattcgccac aaaaacaaaa ttggcaagta 29760 tgctgtttat gctatttggc agccaggtga cactacagag tataatgtta cagttttcca 29820 gggtaaaagt cataaaactt ttatgtatac ttttccattt tatgaaatgt gcgacattac 29880

catgtacatg agcaaacagt ataagttgtg gcccccacaa aattgtgtgg aaaacactgg 29940 cactttctgc tgcactgcta tgctaattac agtgctcgct ttggtctgta ccctactcta 30000

tattaaatac aaaagcagac gcagctttat tgaggaaaag aaaatgcctt aatttactaa 30060 gttacaaagc taatgtcacc actaactgct ttactcgctg cttgcaaaac aaattcaaaa 30120 agttagcatt ataattagaa taggatttaa accccccggt catttcctgc tcaataccat 30180

tcccctgaac aattgactct atgtgggata tgctccagcg ctacaacctt gaagtcaggc 30240 Page 88

Sequence_Listing.txt ttcctggatg tcagcatctg actttggcca gcacctgtcc cgcggatttg ttccagtcca 30300

actacagcga cccaccctaa cagagatgac caacacaacc aacgcggccg ccgctaccgg 30360 acttacatct accacaaata caccccaagt ttctgccttt gtcaataact gggataactt 30420

gggcatgtgg tggttctcca tagcgcttat gtttgtatgc cttattatta tgtggctcat 30480 ctgctgccta aagcgcaaac gcgcccgacc acccatctat agtcccatca ttgtgctaca 30540 cccaaacaat gatggaatcc atagattgga cggactgaaa cacatgttct tttctcttac 30600

agtatgatta aatgagacat gattcctcga gtttttatat tactgaccct tgttgcgctt 30660 ttttgtgcgt gctccacatt ggctgcggtt tctcacatcg aagtagactg cattccagcc 30720 ttcacagtct atttgcttta cggatttgtc accctcacgc tcatctgcag cctcatcact 30780

gtggtcatcg cctttatcca gtgcattgac tgggtctgtg tgcgctttgc atatctcaga 30840 caccatcccc agtacaggga caggactata gctgagcttc ttagaattct ttaattatga 30900 aatttactgt gacttttctg ctgattattt gcaccctatc tgcgttttgt tccccgacct 30960

ccaagcctca aagacatata tcatgcagat tcactcgtat atggaatatt ccaagttgct 31020 acaatgaaaa aagcgatctt tccgaagcct ggttatatgc aatcatctct gttatggtgt 31080

tctgcagtac catcttagcc ctagctatat atccctacct tgacattggc tggaacgcaa 31140

tagatgccat gaaccaccca actttccccg cgcccgctat gcttccactg caacaagttg 31200

ttgccggcgg ctttgtccca gccaatcagc ctcgcccacc ttctcccacc cccactgaaa 31260

tcagctactt taatctaaca ggaggagatg actgacaccc tagatctaga aatggacgga 31320 attattacag agcagcgcct gctagaaaga cgcagggcag cggccgagca acagcgcatg 31380

aatcaagagc tccaagacat ggttaacttg caccagtgca aaaggggtat cttttgtctg 31440

gtaaagcagg ccaaagtcac ctacgacagt aataccaccg gacaccgcct tagctacaag 31500 ttgccaacca agcgtcagaa attggtggtc atggtgggag aaaagcccat taccataact 31560

cagcactcgg tagaaaccga aggctgcatt cactcacctt gtcaaggacc tgaggatctc 31620 tgcaccctta ttaagaccct gtgcggtctc aaagatctta ttccctttaa ctaataaaaa 31680 aaaataataa agcatcactt acttaaaatc agttagcaaa tttctgtcca gtttattcag 31740

cagcacctcc ttgccctcct cccagctctg gtattgcagc ttcctcctgg ctgcaaactt 31800 tctccacaat ctaaatggaa tgtcagtttc ctcctgttcc tgtccatccg cacccactat 31860 cttcatgttg ttgcagatga agcgcgcaag accgtctgaa gataccttca accccgtgta 31920

tccatatgac acggaaaccg gtcctccaac tgtgcctttt cttactcctc cctttgtatc 31980 ccccaatggg tttcaagaga gtccccctgg ggtactctct ttgcgcctat ccgaacctct 32040

agttacctcc aatggcatgc ttgcgctcaa aatgggcaac ggcctctctc tggacgaggc 32100 cggcaacctt acctcccaaa atgtaaccac tgtgagccca cctctcaaaa aaaccaagtc 32160 aaacataaac ctggaaatat ctgcacccct cacagttacc tcagaagccc taactgtggc 32220

tgccgccgca cctctaatgg tcgcgggcaa cacactcacc atgcaatcac aggccccgct 32280 Page 89

Sequence_Listing.txt aaccgtgcac gactccaaac ttagcattgc cacccaagga cccctcacag tgtcagaagg 32340

aaagctagcc ctgcaaacat caggccccct caccaccacc gatagcagta cccttactat 32400 cactgcctca ccccctctaa ctactgccac tggtagcttg ggcattgact tgaaagagcc 32460

catttataca caaaatggaa aactaggact aaagtacggg gctcctttgc atgtaacaga 32520 cgacctaaac actttgaccg tagcaactgg tccaggtgtg actattaata atacttcctt 32580 gcaaactaaa gttactggag ccttgggttt tgattcacaa ggcaatatgc aacttaatgt 32640

agcaggagga ctaaggattg attctcaaaa cagacgcctt atacttgatg ttagttatcc 32700 gtttgatgct caaaaccaac taaatctaag actaggacag ggccctcttt ttataaactc 32760 agcccacaac ttggatatta actacaacaa aggcctttac ttgtttacag cttcaaacaa 32820

ttccaaaaag cttgaggtta acctaagcac tgccaagggg ttgatgtttg acgctacagc 32880 catagccatt aatgcaggag atgggcttga atttggttca cctaatgcac caaacacaaa 32940 tcccctcaaa acaaaaattg gccatggcct agaatttgat tcaaacaagg ctatggttcc 33000

taaactagga actggcctta gttttgacag cacaggtgcc attacagtag gaaacaaaaa 33060 taatgataag ctaactttgt ggaccacacc agctccatct cctaactgta gactaaatgc 33120

agagaaagat gctaaactca ctttggtctt aacaaaatgt ggcagtcaaa tacttgctac 33180

agtttcagtt ttggctgtta aaggcagttt ggctccaata tctggaacag ttcaaagtgc 33240

tcatcttatt ataagatttg acgaaaatgg agtgctacta aacaattcct tcctggaccc 33300

agaatattgg aactttagaa atggagatct tactgaaggc acagcctata caaacgctgt 33360 tggatttatg cctaacctat cagcttatcc aaaatctcac ggtaaaactg ccaaaagtaa 33420

cattgtcagt caagtttact taaacggaga caaaactaaa cctgtaacac taaccattac 33480

actaaacggt acacaggaaa caggagacac aactccaagt gcatactcta tgtcattttc 33540 atgggactgg tctggccaca actacattaa tgaaatattt gccacatcct cttacacttt 33600

ttcatacatt gcccaagaat aaagaatcgt ttgtgttatg tttcaacgtg tttatttttc 33660 aattgcagaa aatttcgaat catttttcat tcagtagtat agccccacca ccacatagct 33720 tatacagatc accgtacctc aactttgtat aataaagttg taatcaaact cacagaaccc 33780

tagtattcaa cctgccacct ccctcccaac acacagagta cacagtcctt tctccccggc 33840 tggccttaaa aagcatcata tcatgggtaa cagacatatt cttaggtgtt atattccaca 33900 cggtttcctg tcgagccaaa cgctcatcag tgatattaat aaactccccg ggcagctcac 33960

ttaagttcat gtcgctgtcc agctgctgag ccacaggctg ctgtccaact tgcggttgct 34020 taacgggcgg cgaaggagaa gtccacgcct acatgggggt agagtcataa tcgtgcatca 34080

ggatagggcg gtggtgctgc agcagcgcgc gaataaactg ctgccgccgc cgctccgtcc 34140 tgcaggaata caacatggca gtggtctcct cagcgatgat tcgcaccgcc cgcagcataa 34200 ggcgccttgt cctccgggca cagcagcgca ccctgatctc acttaaatca gcacagtaac 34260

tgcagcacag caccacaata ttgttcaaaa tcccacagtg caaggcgctg tatccaaagc 34320 Page 90

Sequence_Listing.txt tcatggcggg gaccacagaa cccacgtggc catcatacca caagcgcagg tagattaagt 34380

ggcgacccct cataaacacg ctggacataa acattacctc ttttggcatg ttgtaattca 34440 ccacctcccg gtaccatata aacctctgat taaacatggc gccatccacc accatcctaa 34500

accagctggc caaaacctgc ccgccggcta tacactgcag ggaaccggga ctggaacaat 34560 gacagtggag agcccaggac tcgtaaccat ggatcatcat gctcgtcatg atatcaatgt 34620 tggcacaaca caggcacacg tgcatacact tcctcaggat tacaagctcc tcccgcgtta 34680

gaaccatatc ccagggaaca acccattcct gaatcagcgt aaatcccaca ctgcagggaa 34740 gacctcgcac gtaactcacg ttgtgcattg tcaaagtgtt acattcgggc agcagcggat 34800 gatcctccag tatggtagcg cgggtttctg tctcaaaagg aggtagacga tccctactgt 34860

acggagtgcg ccgagacaac cgagatcgtg ttggtcgtag tgtcatgcca aatggaacgc 34920 cggacgtagt catatttcct gaagcaaaac caggtgcggg cgtgacaaac agatctgcgt 34980 ctccggtctc gccgcttaga tcgctctgtg tagtagttgt agtatatcca ctctctcaaa 35040

gcatccaggc gccccctggc ttcgggttct atgtaaactc cttcatgcgc cgctgccctg 35100 ataacatcca ccaccgcaga ataagccaca cccagccaac ctacacattc gttctgcgag 35160

tcacacacgg gaggagcggg aagagctgga agaaccatgt tttttttttt attccaaaag 35220

attatccaaa acctcaaaat gaagatctat taagtgaacg cgctcccctc cggtggcgtg 35280

gtcaaactct acagccaaag aacagataat ggcatttgta agatgttgca caatggcttc 35340

caaaaggcaa acggccctca cgtccaagtg gacgtaaagg ctaaaccctt cagggtgaat 35400 ctcctctata aacattccag caccttcaac catgcccaaa taattctcat ctcgccacct 35460

tctcaatata tctctaagca aatcccgaat attaagtccg gccattgtaa aaatctgctc 35520

cagagcgccc tccaccttca gcctcaagca gcgaatcatg attgcaaaaa ttcaggttcc 35580 tcacagacct gtataagatt caaaagcgga acattaacaa aaataccgcg atcccgtagg 35640

tcccttcgca gggccagctg aacataatcg tgcaggtctg cacggaccag cgcggccact 35700 tccccgccag gaaccatgac aaaagaaccc acactgatta tgacacgcat actcggagct 35760 atgctaacca gcgtagcccc gatgtaagct tgttgcatgg gcggcgatat aaaatgcaag 35820

gtgctgctca aaaaatcagg caaagcctcg cgcaaaaaag aaagcacatc gtagtcatgc 35880 tcatgcagat aaaggcaggt aagctccgga accaccacag aaaaagacac catttttctc 35940 tcaaacatgt ctgcgggttt ctgcataaac acaaaataaa ataacaaaaa aacatttaaa 36000

cattagaagc ctgtcttaca acaggaaaaa caacccttat aagcataaga cggactacgg 36060 ccatgccggc gtgaccgtaa aaaaactggt caccgtgatt aaaaagcacc accgacagct 36120

cctcggtcat gtccggagtc ataatgtaag actcggtaaa cacatcaggt tgattcacat 36180 cggtcagtgc taaaaagcga ccgaaatagc ccgggggaat acatacccgc aggcgtagag 36240 acaacattac agcccccata ggaggtataa caaaattaat aggagagaaa aacacataaa 36300

cacctgaaaa accctcctgc ctaggcaaaa tagcaccctc ccgctccaga acaacataca 36360 Page 91

Sequence_Listing.txt gcgcttccac agcggcagcc ataacagtca gccttaccag taaaaaagaa aacctattaa 36420

aaaaacacca ctcgacacgg caccagctca atcagtcaca gtgtaaaaaa gggccaagtg 36480 cagagcgagt atatatagga ctaaaaaatg acgtaacggt taaagtccac aaaaaacacc 36540

cagaaaaccg cacgcgaacc tacgcccaga aacgaaagcc aaaaaaccca caacttcctc 36600 aaatcgtcac ttccgttttc ccacgttacg tcacttccca ttttaagaaa actacaattc 36660 ccaacacata caagttactc cgccctaaaa cctacgtcac ccgccccgtt cccacgcccc 36720

gcgccacgtc acaaactcca ccccctcatt atcatattgg cttcaatcca aaataaggta 36780 tattattgat gatg 36794

<210> 6 <211> 36785 <212> DNA <213> Artificial Sequence <220> <223> Synthetic adenovirus genome DBP-P2A-YPet

<400> 6 catcatcaat aatatacctt attttggatt gaagccaata tgataatgag ggggtggagt 60

ttgtgacgtg gcgcggggcg tgggaacggg gcgggtgacg tagtagtgtg gcggaagtgt 120

gatgttgcaa gtgtggcgga acacatgtaa gcgacggatg tggcaaaagt gacgtttttg 180

gtgtgcgccg gtgtacacag gaagtgacaa ttttcgcgcg gttttaggcg gatgttgtag 240

taaatttggg cgtaaccgag taagatttgg ccattttcgc gggaaaactg aataagagga 300 agtgaaatct gaataatttt gtgttactca tagcgcgtaa tatttgtcta gggccgcggg 360

gactttgacc gtttacgtgg agactcgccc aggtgttttt ctcaggtgtt ttccgcgttc 420

cgggtcaaag ttggcgtttt attattatag tcagctgacg tgtagtgtat ttatacccgg 480 tgagttcctc aagaggccac tcttgagtgc cagcgagtag agttttctcc tccgagccgc 540

tccgacaccg ggactgaaaa tgagacatat tatctgccac ggaggtgtta ttaccgaaga 600 aatggccgcc agtcttttgg accagctgat cgaagaggta ctggctgata atcttccacc 660 tcctagccat tttgaaccac ctacccttca cgaactgtat gatttagacg tgacggcccc 720

cgaagatccc aacgaggagg cggtttcgca gatttttccc gactctgtaa tgttggcggt 780 gcaggaaggg attgacttac tcacttttcc gccggcgccc ggttctccgg agccgcctca 840 cctttcccgg cagcccgagc agccggagca gagagccttg ggtccggttt ctatgccaaa 900

ccttgtaccg gaggtgatcg atcttacctg ccacgaggct ggctttccac ccagtgacga 960 cgaggatgaa gagggtgagg agtttgtgtt agattatgtg gagcaccccg ggcacggttg 1020

caggtcttgt cattatcacc ggaggaatac gggggaccca gatattatgt gttcgctttg 1080 ctatatgagg acctgtggca tgtttgtcta cagtaagtga aaattatggg cagtgggtga 1140 tagagtggtg ggtttggtgt ggtaattttt tttttaattt ttacagtttt gtggtttaaa 1200

gaattttgta ttgtgatttt tttaaaaggt cctgtgtctg aacctgagcc tgagcccgag 1260 Page 92

Sequence_Listing.txt ccagaaccgg agcctgcaag acctacccgc cgtcctaaaa tggcgcctgc tatcctgaga 1320

cgcccgacat cacctgtgtc tagagaatgc aatagtagta cggatagctg tgactccggt 1380 ccttctaaca cacctcctga gatacacccg gtggtcccgc tgtgccccat taaaccagtt 1440

gccgtgagag ttggtgggcg tcgccaggct gtggaatgta tcgaggactt gcttaacgag 1500 cctgggcaac ctttggactt gagctgtaaa cgccccaggc cataaggtgt aaacctgtga 1560 ttgcgtgtgt ggttaacgcc tttgtttgct gaatgagttg atgtaagttt aataaagggt 1620

gagataatgt ttaacttgca tggcgtgtta aatggggcgg ggcttaaagg gtatataatg 1680 cgccgtgggc taatcttggt tacatctgac ctcatggagg cttgggagtg tttggaagat 1740 ttttctgctg tgcgtaactt gctggaacag agctctaaca gtacctcttg gttttggagg 1800

tttctgtggg gctcatccca ggcaaagtta gtctgcagaa ttaaggagga ttacaagtgg 1860 gaatttgaag agcttttgaa atcctgtggt gagctgtttg attctttgaa tctgggtcac 1920 caggcgcttt tccaagagaa ggtcatcaag actttggatt tttccacacc ggggcgcgct 1980

gcggctgctg ttgctttttt gagttttata aaggataaat ggagcgaaga aacccatctg 2040 agcggggggt acctgctgga ttttctggcc atgcatctgt ggagagcggt tgtgagacac 2100

aagaatcgcc tgctactgtt gtcttccgtc cgcccggcga taataccgac ggaggagcag 2160

cagcagcagc aggaggaagc caggcggcgg cggcaggagc agagcccatg gaacccgaga 2220

gccggcctgg accctcggga atgaatgttg tacaggtggc tgaactgtat ccagaactga 2280

gacgcatttt gacaattaca gaggatgggc aggggctaaa gggggtaaag agggagcggg 2340 gggcttgtga ggctacagag gaggctagga atctagcttt tagcttaatg accagacacc 2400

gtcctgagtg tattactttt caacagatca aggataattg cgctaatgag cttgatctgc 2460

tggcgcagaa gtattccata gagcagctga ccacttactg gctgcagcca ggggatgatt 2520 ttgaggaggc tattagggta tatgcaaagg tggcacttag gccagattgc aagtacaaga 2580

tcagcaaact tgtaaatatc aggaattgtt gctacatttc tgggaacggg gccgaggtgg 2640 agatagatac ggaggatagg gtggccttta gatgtagcat gataaatatg tggccggggg 2700 tgcttggcat ggacggggtg gttattatga atgtaaggtt tactggcccc aattttagcg 2760

gtacggtttt cctggccaat accaacctta tcctacacgg tgtaagcttc tatgggttta 2820 acaatacctg tgtggaagcc tggaccgatg taagggttcg gggctgtgcc ttttactgct 2880 gctggaaggg ggtggtgtgt cgccccaaaa gcagggcttc aattaagaaa tgcctctttg 2940

aaaggtgtac cttgggtatc ctgtctgagg gtaactccag ggtgcgccac aatgtggcct 3000 ccgactgtgg ttgcttcatg ctagtgaaaa gcgtggctgt gattaagcat aacatggtat 3060

gtggcaactg cgaggacagg gcctctcaga tgctgacctg ctcggacggc aactgtcacc 3120 tgctgaagac cattcacgta gccagccact ctcgcaaggc ctggccagtg tttgagcata 3180 acatactgac ccgctgttcc ttgcatttgg gtaacaggag gggggtgttc ctaccttacc 3240

aatgcaattt gagtcacact aagatattgc ttgagcccga gagcatgtcc aaggtgaacc 3300 Page 93

Sequence_Listing.txt tgaacggggt gtttgacatg accatgaaga tctggaaggt gctgaggtac gatgagaccc 3360

gcaccaggtg cagaccctgc gagtgtggcg gtaaacatat taggaaccag cctgtgatgc 3420 tggatgtgac cgaggagctg aggcccgatc acttggtgct ggcctgcacc cgcgctgagt 3480

ttggctctag cgatgaagat acagattgag gtactgaaat gtgtgggcgt ggcttaaggg 3540 tgggaaagaa tatataaggt gggggtctta tgtagttttg tatctgtttt gcagcagccg 3600 ccgccgccca acttttctat acaaagttgt aatgagcacc aactcgtttg atggaagcat 3660

tgtgagctca tatttgacaa cgcgcatgcc cccatgggcc ggggtgcgtc agaatgtgat 3720 gggctccagc attgatggtc gccccgtcct gcccgcaaac tctactacct tgacctacga 3780 gaccgtgtct ggaacgccgt tggagactgc agcctccgcc gccgcttcag ccgctgcagc 3840

caccgcccgc gggattgtga ctgactttgc tttcctgagc ccgcttgcaa gcagtgcagc 3900 ttcccgttca tccgcccgcg atgacaagtt gacggctctt ttggcacaat tggattcttt 3960 gacccgggaa cttaatgtcg tttctcagca gctgttggat ctgcgccagc aggtttctgc 4020

cctgaaggct tcctcccctc ccaatgcggt ttaaaacata aataaaaaac cagactctgt 4080 ttggatttgg atcaagcata agtgtcttgc tgtctttatt taggggtttt gcgcgcgcgg 4140

taggcccggg accagcggtc tcggtcgttg agggtcctgt gtattttttc caggacgtgg 4200

taaaggtgac tctggatgtt cagatacatg ggcataagcc cgtctctggg gtggaggtag 4260

caccactgca gagcttcatg ctgcggggtg gtgttgtaga tgatccagtc gtagcaggag 4320

cgctgggcgt ggtgcctaaa aatgtctttc agtagcaagc tgattgccag gggcaggccc 4380 ttggtgtaag tgtttacaaa gcggttaagc tgggatgggt gcatacgtgg ggatatgaga 4440

tgcatcttgg actgtatttt taggttggct atgttcccag ccatatccct ccggggattc 4500

atgttgtgca gaaccaccag cacagtgtat ccggtgcact tgggaaattt gtcatgtagc 4560 ttagaaggaa atgcgtggaa gaacttggag acgcccttgt gacctccaag attttccatg 4620

cattcgtcca taatgatggc aatgggccca cgggcggcgg cctgggcgaa gatatttctg 4680 ggatcactaa cgtcatagtt gtgttccagg atgagatcgt cataggccat ttttacaaag 4740 cgcgggcgga gggtgccaga ctgcggtata atggttccat ccggcccagg ggcgtagtta 4800

ccctcacaga tttgcatttc ccacgctttg agttcagatg gggggatcat gtctacctgc 4860 ggggcgatga agaaaacggt ttccggggta ggggagatca gctgggaaga aagcaggttc 4920 ctgagcagct gcgacttacc gcagccggtg ggcccgtaaa tcacacctat taccgggtgc 4980

aactggtagt taagagagct gcagctgccg tcatccctga gcaggggggc cacttcgtta 5040 agcatgtccc tgactcgcat gttttccctg accaaatccg ccagaaggcg ctcgccgccc 5100

agcgatagca gttcttgcaa ggaagcaaag tttttcaacg gtttgagacc gtccgccgta 5160 ggcatgcttt tgagcgtttg accaagcagt tccaggcggt cccacagctc ggtcacctgc 5220 tctacggcat ctcgatccag catatctcct cgtttcgcgg gttggggcgg ctttcgctgt 5280

acggcagtag tcggtgctcg tccagacggg ccagggtcat gtctttccac gggcgcaggg 5340 Page 94

Sequence_Listing.txt tcctcgtcag cgtagtctgg gtcacggtga aggggtgcgc tccgggctgc gcgctggcca 5400

gggtgcgctt gaggctggtc ctgctggtgc tgaagcgctg ccggtcttcg ccctgcgcgt 5460 cggccaggta gcatttgacc atggtgtcat agtccagccc ctccgcggcg tggcccttgg 5520

cgcgcagctt gcccttggag gaggcgccgc acgaggggca gtgcagactt ttgagggcgt 5580 agagcttggg cgcgagaaat accgattccg gggagtaggc atccgcgccg caggccccgc 5640 agacggtctc gcattccacg agccaggtga gctctggccg ttcggggtca aaaaccaggt 5700

ttcccccatg ctttttgatg cgtttcttac ctctggtttc catgagccgg tgtccacgct 5760 cggtgacgaa aaggctgtcc gtgtccccgt atacagactt gagaggcctg tcctcgagcg 5820 gtgttccgcg gtcctcctcg tatagaaact cggaccactc tgagacaaag gctcgcgtcc 5880

aggccagcac gaaggaggct aagtgggagg ggtagcggtc gttgtccact agggggtcca 5940 ctcgctccag ggtgtgaaga cacatgtcgc cctcttcggc atcaaggaag gtgattggtt 6000 tgtaggtgta ggccacgtga ccgggtgttc ctgaaggggg gctataaaag ggggtggggg 6060

cgcgttcgtc ctcactctct tccgcatcgc tgtctgcgag ggccagctgt tggggtgagt 6120 actccctctg aaaagcgggc atgacttctg cgctaagatt gtcagtttcc aaaaacgagg 6180

aggatttgat attcacctgg cccgcggtga tgcctttgag ggtggccgca tccatctggt 6240

cagaaaagac aatctttttg ttgtcaagct tggtggcaaa cgacccgtag agggcgttgg 6300

acagcaactt ggcgatggag cgcagggttt ggtttttgtc gcgatcggcg cgctccttgg 6360

ccgcgatgtt tagctgcacg tattcgcgcg caacgcaccg ccattcggga aagacggtgg 6420 tgcgctcgtc gggcaccagg tgcacgcgcc aaccgcggtt gtgcagggtg acaaggtcaa 6480

cgctggtggc tacctctccg cgtaggcgct cgttggtcca gcagaggcgg ccgcccttgc 6540

gcgagcagaa tggcggtagg gggtctagct gcgtctcgtc cggggggtct gcgtccacgg 6600 taaagacccc gggcagcagg cgcgcgtcga agtagtctat cttgcatcct tgcaagtcta 6660

gcgcctgctg ccatgcgcgg gcggcaagcg cgcgctcgta tgggttgagt gggggacccc 6720 atggcatggg gtgggtgagc gcggaggcgt acatgccgca aatgtcgtaa acgtagaggg 6780 gctctctgag tattccaaga tatgtagggt agcatcttcc accgcggatg ctggcgcgca 6840

cgtaatcgta tagttcgtgc gagggagcga ggaggtcggg accgaggttg ctacgggcgg 6900 gctgctctgc tcggaagact atctgcctga agatggcatg tgagttggat gatatggttg 6960 gacgctggaa gacgttgaag ctggcgtctg tgagacctac cgcgtcacgc acgaaggagg 7020

cgtaggagtc gcgcagcttg ttgaccagct cggcggtgac ctgcacgtct agggcgcagt 7080 agtccagggt ttccttgatg atgtcatact tatcctgtcc cttttttttc cacagctcgc 7140

ggttgaggac aaactcttcg cggtctttcc agtactcttg gatcggaaac ccgtcggcct 7200 ccgaacggta agagcctagc atgtagaact ggttgacggc ctggtaggcg cagcatccct 7260 tttctacggg tagcgcgtat gcctgcgcgg ccttccggag cgaggtgtgg gtgagcgcaa 7320

aggtgtccct gaccatgact ttgaggtact ggtatttgaa gtcagtgtcg tcgcatccgc 7380 Page 95

Sequence_Listing.txt cctgctccca gagcaaaaag tccgtgcgct ttttggaacg cggatttggc agggcgaagg 7440

tgacatcgtt gaagagtatc tttcccgcgc gaggcataaa gttgcgtgtg atgcggaagg 7500 gtcccggcac ctcggaacgg ttgttaatta cctgggcggc gagcacgatc tcgtcaaagc 7560

cgttgatgtt gtggcccaca atgtaaagtt ccaagaagcg cgggatgccc ttgatggaag 7620 gcaatttttt aagttcctcg taggtgagct cttcagggga gctgagcccg tgctctgaaa 7680 gggcccagtc tgcaagatga gggttggaag cgacgaatga gctccacagg tcacgggcca 7740

ttagcatttg caggtggtcg cgaaaggtcc taaactggcg acctatggcc attttttctg 7800 gggtgatgca gtagaaggta agcgggtctt gttcccagcg gtcccatcca aggttcgcgg 7860 ctaggtctcg cgcggcagtc actagaggct catctccgcc gaacttcatg accagcatga 7920

agggcacgag ctgcttccca aaggccccca tccaagtata ggtctctaca tcgtaggtga 7980 caaagagacg ctcggtgcga ggatgcgagc cgatcgggaa gaactggatc tcccgccacc 8040 aattggagga gtggctattg atgtggtgaa agtagaagtc cctgcgacgg gccgaacact 8100

cgtgctggct tttgtaaaaa cgtgcgcagt actggcagcg gtgcacgggc tgtacatcct 8160 gcacgaggtt gacctgacga ccgcgcacaa ggaagcagag tgggaatttg agcccctcgc 8220

ctggcgggtt tggctggtgg tcttctactt cggctgcttg tccttgaccg tctggctgct 8280

cgaggggagt tacggtggat cggaccacca cgccgcgcga gcccaaagtc cagatgtccg 8340

cgcgcggcgg tcggagcttg atgacaacat cgcgcagatg ggagctgtcc atggtctgga 8400

gctcccgcgg cgtcaggtca ggcgggagct cctgcaggtt tacctcgcat agacgggtca 8460 gggcgcgggc tagatccagg tgatacctaa tttccagggg ctggttggtg gcggcgtcga 8520

tggcttgcaa gaggccgcat ccccgcggcg cgactacggt accgcgcggc gggcggtggg 8580

ccgcgggggt gtccttggat gatgcatcta aaagcggtga cgcgggcgag cccccggagg 8640 tagggggggc tccggacccg ccgggagagg gggcaggggc acgtcggcgc cgcgcgcggg 8700

caggagctgg tgctgcgcgc gtaggttgct ggcgaacgcg acgacgcggc ggttgatctc 8760 ctgaatctgg cgcctctgcg tgaagacgac gggcccggtg agcttgagcc tgaaagagag 8820 ttcgacagaa tcaatttcgg tgtcgttgac ggcggcctgg cgcaaaatct cctgcacgtc 8880

tcctgagttg tcttgatagg cgatctcggc catgaactgc tcgatctctt cctcctggag 8940 atctccgcgt ccggctcgct ccacggtggc ggcgaggtcg ttggaaatgc gggccatgag 9000 ctgcgagaag gcgttgaggc ctccctcgtt ccagacgcgg ctgtagacca cgcccccttc 9060

ggcatcgcgg gcgcgcatga ccacctgcgc gagattgagc tccacgtgcc gggcgaagac 9120 ggcgtagttt cgcaggcgct gaaagaggta gttgagggtg gtggcggtgt gttctgccac 9180

gaagaagtac ataacccagc gtcgcaacgt ggattcgttg atatccccca aggcctcaag 9240 gcgctccatg gcctcgtaga agtccacggc gaagttgaaa aactgggagt tgcgcgccga 9300 cacggttaac tcctcctcca gaagacggat gagctcggcg acagtgtcgc gcacctcgcg 9360

ctcaaaggct acaggggcct cttcttcttc ttcaatctcc tcttccataa gggcctcccc 9420 Page 96

Sequence_Listing.txt ttcttcttct tctggcggcg gtgggggagg ggggacacgg cggcgacgac ggcgcaccgg 9480

gaggcggtcg acaaagcgct cgatcatctc cccgcggcga cggcgcatgg tctcggtgac 9540 ggcgcggccg ttctcgcggg ggcgcagttg gaagacgccg cccgtcatgt cccggttatg 9600

ggttggcggg gggctgccat gcggcaggga tacggcgcta acgatgcatc tcaacaattg 9660 ttgtgtaggt actccgccgc cgagggacct gagcgagtcc gcatcgaccg gatcggaaaa 9720 cctctcgaga aaggcgtcta accagtcaca gtcgcaaggt aggctgagca ccgtggcggg 9780

cggcagcggg cggcggtcgg ggttgtttct ggcggaggtg ctgctgatga tgtaattaaa 9840 gtaggcggtc ttgagacggc ggatggtcga cagaagcacc atgtccttgg gtccggcctg 9900 ctgaatgcgc aggcggtcgg ccatgcccca ggcttcgttt tgacatcggc gcaggtcttt 9960

gtagtagtct tgcatgagcc tttctaccgg cacttcttct tctccttcct cttgtcctgc 10020 atctcttgca tctatcgctg cggcggcggc ggagtttggc cgtaggtggc gccctcttcc 10080 tcccatgcgt gtgaccccga agcccctcat cggctgaagc agggctaggt cggcgacaac 10140

gcgctcggct aatatggcct gctgcacctg cgtgagggta gactggaagt catccatgtc 10200 cacaaagcgg tggtatgcgc ccgtgttgat ggtgtaagtg cagttggcca taacggacca 10260

gttaacggtc tggtgacccg gctgcgagag ctcggtgtac ctgagacgcg agtaagccct 10320

cgagtcaaat acgtagtcgt tgcaagtccg caccaggtac tggtatccca ccaaaaagtg 10380

cggcggcggc tggcggtaga ggggccagcg tagggtggcc ggggctccgg gggcgagatc 10440

ttccaacata aggcgatgat atccgtagat gtacctggac atccaggtga tgccggcggc 10500 ggtggtggag gcgcgcggaa agtcgcggac gcggttccag atgttgcgca gcggcaaaaa 10560

gtgctccatg gtcgggacgc tctggccggt caggcgcgcg caatcgttga cgctctagac 10620

cgtgcaaaag gagagcctgt aagcgggcac tcttccgtgg tctggtggat aaattcgcaa 10680 gggtatcatg gcggacgacc ggggttcgag ccccgtatcc ggccgtccgc cgtgatccat 10740

gcggttaccg cccgcgtgtc gaacccaggt gtgcgacgtc agacaacggg ggagtgctcc 10800 ttttggcttc cttccaggcg cggcggctgc tgcgctagct tttttggcca ctggccgcgc 10860 gcagcgtaag cggttaggct ggaaagcgaa agcattaagt ggctcgctcc ctgtagccgg 10920

agggttattt tccaagggtt gagtcgcggg acccccggtt cgagtctcgg accggccgga 10980 ctgcggcgaa cgggggtttg cctccccgtc atgcaagacc ccgcttgcaa attcctccgg 11040 aaacagggac gagccccttt tttgcttttc ccagatgcat ccggtgctgc ggcagatgcg 11100

cccccctcct cagcagcggc aagagcaaga gcagcggcag acatgcaggg caccctcccc 11160 tcctcctacc gcgtcaggag gggcgacatc cgcggttgac gcggcagcag atggtgatta 11220

cgaacccccg cggcgccggg cccggcacta cctggacttg gaggagggcg agggcctggc 11280 gcggctagga gcgccctctc ctgagcggta cccaagggtg cagctgaagc gtgatacgcg 11340 tgaggcgtac gtgccgcggc agaacctgtt tcgcgaccgc gagggagagg agcccgagga 11400

gatgcgggat cgaaagttcc acgcagggcg cgagctgcgg catggcctga atcgcgagcg 11460 Page 97

Sequence_Listing.txt gttgctgcgc gaggaggact ttgagcccga cgcgcgaacc gggattagtc ccgcgcgcgc 11520

acacgtggcg gccgccgacc tggtaaccgc atacgagcag acggtgaacc aggagattaa 11580 ctttcaaaaa agctttaaca accacgtgcg tacgcttgtg gcgcgcgagg aggtggctat 11640

aggactgatg catctgtggg actttgtaag cgcgctggag caaaacccaa atagcaagcc 11700 gctcatggcg cagctgttcc ttatagtgca gcacagcagg gacaacgagg cattcaggga 11760 tgcgctgcta aacatagtag agcccgaggg ccgctggctg ctcgatttga taaacatcct 11820

gcagagcata gtggtgcagg agcgcagctt gagcctggct gacaaggtgg ccgccatcaa 11880 ctattccatg cttagcctgg gcaagtttta cgcccgcaag atataccata ccccttacgt 11940 tcccatagac aaggaggtaa agatcgaggg gttctacatg cgcatggcgc tgaaggtgct 12000

taccttgagc gacgacctgg gcgtttatcg caacgagcgc atccacaagg ccgtgagcgt 12060 gagccggcgg cgcgagctca gcgaccgcga gctgatgcac agcctgcaaa gggccctggc 12120 tggcacgggc agcggcgata gagaggccga gtcctacttt gacgcgggcg ctgacctgcg 12180

ctgggcccca agccgacgcg ccctggaggc agctggggcc ggacctgggc tggcggtggc 12240 acccgcgcgc gctggcaacg tcggcggcgt ggaggaatat gacgaggacg atgagtacga 12300

gccagaggac ggcgagtact aagcggtgat gtttctgatc agatgatgca agacgcaacg 12360

gacccggcgg tgcgggcggc gctgcagagc cagccgtccg gccttaactc cacggacgac 12420

tggcgccagg tcatggaccg catcatgtcg ctgactgcgc gcaatcctga cgcgttccgg 12480

cagcagccgc aggccaaccg gctctccgca attctggaag cggtggtccc ggcgcgcgca 12540 aaccccacgc acgagaaggt gctggcgatc gtaaacgcgc tggccgaaaa cagggccatc 12600

cggcccgacg aggccggcct ggtctacgac gcgctgcttc agcgcgtggc tcgttacaac 12660

agcggcaacg tgcagaccaa cctggaccgg ctggtggggg atgtgcgcga ggccgtggcg 12720 cagcgtgagc gcgcgcagca gcagggcaac ctgggctcca tggttgcact aaacgccttc 12780

ctgagtacac agcccgccaa cgtgccgcgg ggacaggagg actacaccaa ctttgtgagc 12840 gcactgcggc taatggtgac tgagacaccg caaagtgagg tgtaccagtc tgggccagac 12900 tattttttcc agaccagtag acaaggcctg cagaccgtaa acctgagcca ggctttcaaa 12960

aacttgcagg ggctgtgggg ggtgcgggct cccacaggcg accgcgcgac cgtgtctagc 13020 ttgctgacgc ccaactcgcg cctgttgctg ctgctaatag cgcccttcac ggacagtggc 13080 agcgtgtccc gggacacata cctaggtcac ttgctgacac tgtaccgcga ggccataggt 13140

caggcgcatg tggacgagca tactttccag gagattacaa gtgtcagccg cgcgctgggg 13200 caggaggaca cgggcagcct ggaggcaacc ctaaactacc tgctgaccaa ccggcggcag 13260

aagatcccct cgttgcacag tttaaacagc gaggaggagc gcattttgcg ctacgtgcag 13320 cagagcgtga gccttaacct gatgcgcgac ggggtaacgc ccagcgtggc gctggacatg 13380 accgcgcgca acatggaacc gggcatgtat gcctcaaacc ggccgtttat caaccgccta 13440

atggactact tgcatcgcgc ggccgccgtg aaccccgagt atttcaccaa tgccatcttg 13500 Page 98

Sequence_Listing.txt aacccgcact ggctaccgcc ccctggtttc tacaccgggg gattcgaggt gcccgagggt 13560

aacgatggat tcctctggga cgacatagac gacagcgtgt tttccccgca accgcagacc 13620 ctgctagagt tgcaacagcg cgagcaggca gaggcggcgc tgcgaaagga aagcttccgc 13680

aggccaagca gcttgtccga tctaggcgct gcggccccgc ggtcagatgc tagtagccca 13740 tttccaagct tgatagggtc tcttaccagc actcgcacca cccgcccgcg cctgctgggc 13800 gaggaggagt acctaaacaa ctcgctgctg cagccgcagc gcgaaaaaaa cctgcctccg 13860

gcatttccca acaacgggat agagagccta gtggacaaga tgagtagatg gaagacgtac 13920 gcgcaggagc acagggacgt gccaggcccg cgcccgccca cccgtcgtca aaggcacgac 13980 cgtcagcggg gtctggtgtg ggaggacgat gactcggcag acgacagcag cgtcctggat 14040

ttgggaggga gtggcaaccc gtttgcgcac cttcgcccca ggctggggag aatgttttaa 14100 aaaaaaaaaa gcatgatgca aaataaaaaa ctcaccaagg ccatggcacc gagcgttggt 14160 tttcttgtat tccccttagt atgcggcgcg cggcgatgta tgaggaaggt cctcctccct 14220

cctacgagag tgtggtgagc gcggcgccag tggcggcggc gctgggttct cccttcgatg 14280 ctcccctgga cccgccgttt gtgcctccgc ggtacctgcg gcctaccggg gggagaaaca 14340

gcatccgtta ctctgagttg gcacccctat tcgacaccac ccgtgtgtac ctggtggaca 14400

acaagtcaac ggatgtggca tccctgaact accagaacga ccacagcaac tttctgacca 14460

cggtcattca aaacaatgac tacagcccgg gggaggcaag cacacagacc atcaatcttg 14520

acgaccggtc gcactggggc ggcgacctga aaaccatcct gcataccaac atgccaaatg 14580 tgaacgagtt catgtttacc aataagttta aggcgcgggt gatggtgtcg cgcttgccta 14640

ctaaggacaa tcaggtggag ctgaaatacg agtgggtgga gttcacgctg cccgagggca 14700

actactccga gaccatgacc atagacctta tgaacaacgc gatcgtggag cactacttga 14760 aagtgggcag acagaacggg gttctggaaa gcgacatcgg ggtaaagttt gacacccgca 14820

acttcagact ggggtttgac cccgtcactg gtcttgtcat gcctggggta tatacaaacg 14880 aagccttcca tccagacatc attttgctgc caggatgcgg ggtggacttc acccacagcc 14940 gcctgagcaa cttgttgggc atccgcaagc ggcaaccctt ccaggagggc tttaggatca 15000

cctacgatga tctggagggt ggtaacattc ccgcactgtt ggatgtggac gcctaccagg 15060 cgagcttgaa agatgacacc gaacagggcg ggggtggcgc aggcggcagc aacagcagtg 15120 gcagcggcgc ggaagagaac tccaacgcgg cagccgcggc aatgcagccg gtggaggaca 15180

tgaacgatca tgccattcgc ggcgacacct ttgccacacg ggctgaggag aagcgcgctg 15240 aggccgaagc agcggccgaa gctgccgccc ccgctgcgca acccgaggtc gagaagcctc 15300

agaagaaacc ggtgatcaaa cccctgacag aggacagcaa gaaacgcagt tacaacctaa 15360 taagcaatga cagcaccttc acccagtacc gcagctggta ccttgcatac aactacggcg 15420 accctcagac cggaatccgc tcatggaccc tgctttgcac tcctgacgta acctgcggct 15480

cggagcaggt ctactggtcg ttgccagaca tgatgcaaga ccccgtgacc ttccgctcca 15540 Page 99

Sequence_Listing.txt cgcgccagat cagcaacttt ccggtggtgg gcgccgagct gttgcccgtg cactccaaga 15600

gcttctacaa cgaccaggcc gtctactccc aactcatccg ccagtttacc tctctgaccc 15660 acgtgttcaa tcgctttccc gagaaccaga ttttggcgcg cccgccagcc cccaccatca 15720

ccaccgtcag tgaaaacgtt cctgctctca cagatcacgg gacgctaccg ctgcgcaaca 15780 gcatcggagg agtccagcga gtgaccatta ctgacgccag acgccgcacc tgcccctacg 15840 tttacaaggc cctgggcata gtctcgccgc gcgtcctatc gagccgcact ttttgagcaa 15900

gcatgtccat ccttatatcg cccagcaata acacaggctg gggcctgcgc ttcccaagca 15960 agatgtttgg cggggccaag aagcgctccg accaacaccc agtgcgcgtg cgcgggcact 16020 accgcgcgcc ctggggcgcg cacaaacgcg gccgcactgg gcgcaccacc gtcgatgacg 16080

ccatcgacgc ggtggtggag gaggcgcgca actacacgcc cacgccgcca ccagtgtcca 16140 cagtggacgc ggccattcag accgtggtgc gcggagcccg gcgctatgct aaaatgaaga 16200 gacggcggag gcgcgtagca cgtcgccacc gccgccgacc cggcactgcc gcccaacgcg 16260

cggcggcggc cctgcttaac cgcgcacgtc gcaccggccg acgggcggcc atgcgggccg 16320 ctcgaaggct ggccgcgggt attgtcactg tgccccccag gtccaggcga cgagcggccg 16380

ccgcagcagc cgcggccatt agtgctatga ctcagggtcg caggggcaac gtgtattggg 16440

tgcgcgactc ggttagcggc ctgcgcgtgc ccgtgcgcac ccgccccccg cgcaactaga 16500

ttgcaagaaa aaactactta gactcgtact gttgtatgta tccagcggcg gcggcgcgca 16560

acgaagctat gtccaagcgc aaaatcaaag aagagatgct ccaggtcatc gcgccggaga 16620 tctatggccc cccgaagaag gaagagcagg attacaagcc ccgaaagcta aagcgggtca 16680

aaaagaaaaa gaaagatgat gatgatgaac ttgacgacga ggtggaactg ctgcacgcta 16740

ccgcgcccag gcgacgggta cagtggaaag gtcgacgcgt aaaacgtgtt ttgcgacccg 16800 gcaccaccgt agtctttacg cccggtgagc gctccacccg cacctacaag cgcgtgtatg 16860

atgaggtgta cggcgacgag gacctgcttg agcaggccaa cgagcgcctc ggggagtttg 16920 cctacggaaa gcggcataag gacatgctgg cgttgccgct ggacgagggc aacccaacac 16980 ctagcctaaa gcccgtaaca ctgcagcagg tgctgcccgc gcttgcaccg tccgaagaaa 17040

agcgcggcct aaagcgcgag tctggtgact tggcacccac cgtgcagctg atggtaccca 17100 agcgccagcg actggaagat gtcttggaaa aaatgaccgt ggaacctggg ctggagcccg 17160 aggtccgcgt gcggccaatc aagcaggtgg cgccgggact gggcgtgcag accgtggacg 17220

ttcagatacc cactaccagt agcaccagta ttgccaccgc cacagagggc atggagacac 17280 aaacgtcccc ggttgcctca gcggtggcgg atgccgcggt gcaggcggtc gctgcggccg 17340

cgtccaagac ctctacggag gtgcaaacgg acccgtggat gtttcgcgtt tcagcccccc 17400 ggcgcccgcg cggttcgagg aagtacggcg ccgccagcgc gctactgccc gaatatgccc 17460 tacatccttc cattgcgcct acccccggct atcgtggcta cacctaccgc cccagaagac 17520

gagcaactac ccgacgccga accaccactg gaacccgccg ccgccgtcgc cgtcgccagc 17580 Page 100

Sequence_Listing.txt ccgtgctggc cccgatttcc gtgcgcaggg tggctcgcga aggaggcagg accctggtgc 17640

tgccaacagc gcgctaccac cccagcatcg tttaaaagcc ggtctttgtg gttcttgcag 17700 atatggccct cacctgccgc ctccgtttcc cggtgccggg attccgagga agaatgcacc 17760

gtaggagggg catggccggc cacggcctga cgggcggcat gcgtcgtgcg caccaccggc 17820 ggcggcgcgc gtcgcaccgt cgcatgcgcg gcggtatcct gcccctcctt attccactga 17880 tcgccgcggc gattggcgcc gtgcccggaa ttgcatccgt ggccttgcag gcgcagagac 17940

actgattaaa aacaagttgc atgtggaaaa atcaaaataa aaagtctgga ctctcacgct 18000 cgcttggtcc tgtaactatt ttgtagaatg gaagacatca actttgcgtc tctggccccg 18060 cgacacggct cgcgcccgtt catgggaaac tggcaagata tcggcaccag caatatgagc 18120

ggtggcgcct tcagctgggg ctcgctgtgg agcggcatta aaaatttcgg ttccaccgtt 18180 aagaactatg gcagcaaggc ctggaacagc agcacaggcc agatgctgag ggataagttg 18240 aaagagcaaa atttccaaca aaaggtggta gatggcctgg cctctggcat tagcggggtg 18300

gtggacctgg ccaaccaggc agtgcaaaat aagattaaca gtaagcttga tccccgccct 18360 cccgtagagg agcctccacc ggccgtggag acagtgtctc cagaggggcg tggcgaaaag 18420

cgtccgcgcc ccgacaggga agaaactctg gtgacgcaaa tagacgagcc tccctcgtac 18480

gaggaggcac taaagcaagg cctgcccacc acccgtccca tcgcgcccat ggctaccgga 18540

gtgctgggcc agcacacacc cgtaacgctg gacctgcctc cccccgccga cacccagcag 18600

aaacctgtgc tgccaggccc gaccgccgtt gttgtaaccc gtcctagccg cgcgtccctg 18660 cgccgcgccg ccagcggtcc gcgatcgttg cggcccgtag ccagtggcaa ctggcaaagc 18720

acactgaaca gcatcgtggg tctgggggtg caatccctga agcgccgacg atgcttctga 18780

atagctaacg tgtcgtatgt gtgtcatgta tgcgtccatg tcgccgccag aggagctgct 18840 gagccgccgc gcgcccgctt tccaagatgg ctaccccttc gatgatgccg cagtggtctt 18900

acatgcacat ctcgggccag gacgcctcgg agtacctgag ccccgggctg gtgcagtttg 18960 cccgcgccac cgagacgtac ttcagcctga ataacaagtt tagaaacccc acggtggcgc 19020 ctacgcacga cgtgaccaca gaccggtccc agcgtttgac gctgcggttc atccctgtgg 19080

accgtgagga tactgcgtac tcgtacaagg cgcggttcac cctagctgtg ggtgataacc 19140 gtgtgctgga catggcttcc acgtactttg acatccgcgg cgtgctggac aggggcccta 19200 cttttaagcc ctactctggc actgcctaca acgccctggc tcccaagggt gccccaaatc 19260

cttgcgaatg ggatgaagct gctactgctc ttgaaataaa cctagaagaa gaggacgatg 19320 acaacgaaga cgaagtagac gagcaagctg agcagcaaaa aactcacgta tttgggcagg 19380

cgccttattc tggtataaat attacaaagg agggtattca aataggtgtc gaaggtcaaa 19440 cacctaaata tgccgataaa acatttcaac ctgaacctca aataggagaa tctcagtggt 19500 acgaaactga aattaatcat gcagctggga gagtccttaa aaagactacc ccaatgaaac 19560

catgttacgg ttcatatgca aaacccacaa atgaaaatgg agggcaaggc attcttgtaa 19620 Page 101

Sequence_Listing.txt agcaacaaaa tggaaagcta gaaagtcaag tggaaatgca atttttctca actactgagg 19680

cgaccgcagg caatggtgat aacttgactc ctaaagtggt attgtacagt gaagatgtag 19740 atatagaaac cccagacact catatttctt acatgcccac tattaaggaa ggtaactcac 19800

gagaactaat gggccaacaa tctatgccca acaggcctaa ttacattgct tttagggaca 19860 attttattgg tctaatgtat tacaacagca cgggtaatat gggtgttctg gcgggccaag 19920 catcgcagtt gaatgctgtt gtagatttgc aagacagaaa cacagagctt tcataccagc 19980

ttttgcttga ttccattggt gatagaacca ggtacttttc tatgtggaat caggctgttg 20040 acagctatga tccagatgtt agaattattg aaaatcatgg aactgaagat gaacttccaa 20100 attactgctt tccactggga ggtgtgatta atacagagac tcttaccaag gtaaaaccta 20160

aaacaggtca ggaaaatgga tgggaaaaag atgctacaga attttcagat aaaaatgaaa 20220 taagagttgg aaataatttt gccatggaaa tcaatctaaa tgccaacctg tggagaaatt 20280 tcctgtactc caacatagcg ctgtatttgc ccgacaagct aaagtacagt ccttccaacg 20340

taaaaatttc tgataaccca aacacctacg actacatgaa caagcgagtg gtggctcccg 20400 ggttagtgga ctgctacatt aaccttggag cacgctggtc ccttgactat atggacaacg 20460

tcaacccatt taaccaccac cgcaatgctg gcctgcgcta ccgctcaatg ttgctgggca 20520

atggtcgcta tgtgcccttc cacatccagg tgcctcagaa gttctttgcc attaaaaacc 20580

tccttctcct gccgggctca tacacctacg agtggaactt caggaaggat gttaacatgg 20640

ttctgcagag ctccctagga aatgacctaa gggttgacgg agccagcatt aagtttgata 20700 gcatttgcct ttacgccacc ttcttcccca tggcccacaa caccgcctcc acgcttgagg 20760

ccatgcttag aaacgacacc aacgaccagt cctttaacga ctatctctcc gccgccaaca 20820

tgctctaccc tatacccgcc aacgctacca acgtgcccat atccatcccc tcccgcaact 20880 gggcggcttt ccgcggctgg gccttcacgc gccttaagac taaggaaacc ccatcactgg 20940

gctcgggcta cgacccttat tacacctact ctggctctat accctaccta gatggaacct 21000 tttacctcaa ccacaccttt aagaaggtgg ccattacctt tgactcttct gtcagctggc 21060 ctggcaatga ccgcctgctt acccccaacg agtttgaaat taagcgctca gttgacgggg 21120

agggttacaa cgttgcccag tgtaacatga ccaaagactg gttcctggta caaatgctag 21180 ctaactataa cattggctac cagggcttct atatcccaga gagctacaag gaccgcatgt 21240 actccttctt tagaaacttc cagcccatga gccgtcaggt ggtggatgat actaaataca 21300

aggactacca acaggtgggc atcctacacc aacacaacaa ctctggattt gttggctacc 21360 ttgcccccac catgcgcgaa ggacaggcct accctgctaa cttcccctat ccgcttatag 21420

gcaagaccgc agttgacagc attacccaga aaaagtttct ttgcgatcgc accctttggc 21480 gcatcccatt ctccagtaac tttatgtcca tgggcgcact cacagacctg ggccaaaacc 21540 ttctctacgc caactccgcc cacgcgctag acatgacttt tgaggtggat cccatggacg 21600

agcccaccct tctttatgtt ttgtttgaag tctttgacgt ggtccgtgtg caccagccgc 21660 Page 102

Sequence_Listing.txt accgcggcgt catcgaaacc gtgtacctgc gcacgccctt ctcggccggc aacgccacaa 21720

cataaagaag caagcaacat caacaacagc tgccgccatg ggctccagtg agcaggaact 21780 gaaagccatt gtcaaagatc ttggttgtgg gccatatttt ttgggcacct atgacaagcg 21840

ctttccaggc tttgtttctc cacacaagct cgcctgcgcc atagtcaata cggccggtcg 21900 cgagactggg ggcgtacact ggatggcctt tgcctggaac ccgcactcaa aaacatgcta 21960 cctctttgag ccctttggct tttctgacca gcgactcaag caggtttacc agtttgagta 22020

cgagtcactc ctgcgccgta gcgccattgc ttcttccccc gaccgctgta taacgctgga 22080 aaagtccacc caaagcgtac aggggcccaa ctcggccgcc tgtggactat tctgctgcat 22140 gtttctccac gcctttgcca actggcccca aactcccatg gatcacaacc ccaccatgaa 22200

ccttattacc ggggtaccca actccatgct caacagtccc caggtacagc ccaccctgcg 22260 tcgcaaccag gaacagctct acagcttcct ggagcgccac tcgccctact tccgcagcca 22320 cagtgcgcag attaggagcg ccacttcttt ttgtcacttg aaaaacatgt aaaaataatg 22380

tactagagac actttcaata aaggcaaatg cttttatttg tacactctcg ggtgattatt 22440 tacccccacc cttgccgtct gcgccgttta cttatagagc tcgttcatgc cctcggtgat 22500

gccggcggcg gtcaggaact ccagcagcac catgtggtcc cgcttctcgt tggggtcctt 22560

gaacagggcg ctctggtagc tcaggtagtg gttgtcgggc agcagcacgg ggccgtcgcc 22620

gatgggggtg ttctgctggt agtggtcggc cagctgcacg ccgccgtcct cgatgttgtg 22680

ccggatcttg aagttggcct tgatgccgtt cttctgcttg tcggcggtga tgtacacgtt 22740 gtggctgttg tagttgtact ccagcttgtg gcccaggatg ttgccgtcct ccttgaagtc 22800

gatgcccttc agctcgatcc ggttcaccag ggtgtcgccc tcgaacttca cctcggcccg 22860

ggtcttgtag ttgccgtcgt ccttgaagaa gatggtccgc tcctgcacgt agccctcggg 22920 catggcgctc ttgaagaagt cgtgctgctt catgtggtcg gggtaccggg cgaagcactg 22980

cacgccgtag cccagggtgg tcaccagggt gggccagggc acgggcagct tgccggtggt 23040 gcacagcagc ttcagggtca gcttgccgta ggtggcgtcg ccctcgccct cgccgctcac 23100 gctgaacttg tggccgttca cgtcgccgtc cagctccacc aggatgggca ccacgccggt 23160

gaacagctct tcgcctttgc tcaccattgg gccaggattc tcctcgacgt caccagcctg 23220 cttcagcagg ctgaagttag tagctccgct tccaaaatca aaggggttct gccgcgcatc 23280 gctatgcgcc actggcaggg acacgttgcg atactggtgt ttagtgctcc acttaaactc 23340

aggcacaacc atccgcggca gctcggtgaa gttttcactc cacaggctgc gcaccatcac 23400 caacgcgttt agcaggtcgg gcgccgatat cttgaagtcg cagttggggc ctccgccctg 23460

cgcgcgcgag ttgcgataca cagggttgca gcactggaac actatcagcg ccgggtggtg 23520 cacgctggcc agcacgctct tgtcggagat cagatccgcg tccaggtcct ccgcgttgct 23580 cagggcgaac ggagtcaact ttggtagctg ccttcccaaa aagggcgcgt gcccaggctt 23640

tgagttgcac tcgcaccgta gtggcatcaa aaggtgaccg tgcccggtct gggcgttagg 23700 Page 103

Sequence_Listing.txt atacagcgcc tgcataaaag ccttgatctg cttaaaagcc acctgagcct ttgcgccttc 23760

agagaagaac atgccgcaag acttgccgga aaactgattg gccggacagg ccgcgtcgtg 23820 cacgcagcac cttgcgtcgg tgttggagat ctgcaccaca tttcggcccc accggttctt 23880

cacgatcttg gccttgctag actgctcctt cagcgcgcgc tgcccgtttt cgctcgtcac 23940 atccatttca atcacgtgct ccttatttat cataatgctt ccgtgtagac acttaagctc 24000 gccttcgatc tcagcgcagc ggtgcagcca caacgcgcag cccgtgggct cgtgatgctt 24060

gtaggtcacc tctgcaaacg actgcaggta cgcctgcagg aatcgcccca tcatcgtcac 24120 aaaggtcttg ttgctggtga aggtcagctg caacccgcgg tgctcctcgt tcagccaggt 24180 cttgcatacg gccgccagag cttccacttg gtcaggcagt agtttgaagt tcgcctttag 24240

atcgttatcc acgtggtact tgtccatcag cgcgcgcgca gcctccatgc ccttctccca 24300 cgcagacacg atcggcacac tcagcgggtt catcaccgta atttcacttt ccgcttcgct 24360 gggctcttcc tcttcctctt gcgtccgcat accacgcgcc actgggtcgt cttcattcag 24420

ccgccgcact gtgcgcttac ctcctttgcc atgcttgatt agcaccggtg ggttgctgaa 24480 acccaccatt tgtagcgcca catcttctct ttcttcctcg ctgtccacga ttacctctgg 24540

tgatggcggg cgctcgggct tgggagaagg gcgcttcttt ttcttcttgg gcgcaatggc 24600

caaatccgcc gccgaggtcg atggccgcgg gctgggtgtg cgcggcacca gcgcgtcttg 24660

tgatgagtct tcctcgtcct cggactcgat acgccgcctc atccgctttt ttgggggcgc 24720

ccggggaggc ggcggcgacg gggacgggga cgacacgtcc tccatggttg ggggacgtcg 24780 cgccgcaccg cgtccgcgct cgggggtggt ttcgcgctgc tcctcttccc gactggccat 24840

ttccttctcc tataggcaga aaaagatcat ggagtcagtc gagaagaagg acagcctaac 24900

cgccccctct gagttcgcca ccaccgcctc caccgatgcc gccaacgcgc ctaccacctt 24960 ccccgtcgag gcacccccgc ttgaggagga ggaagtgatt atcgagcagg acccaggttt 25020

tgtaagcgaa gacgacgagg accgctcagt accaacagag gataaaaagc aagaccagga 25080 caacgcagag gcaaacgagg aacaagtcgg gcggggggac gaaaggcatg gcgactacct 25140 agatgtggga gacgacgtgc tgttgaagca tctgcagcgc cagtgcgcca ttatctgcga 25200

cgcgttgcaa gagcgcagcg atgtgcccct cgccatagcg gatgtcagcc ttgcctacga 25260 acgccaccta ttctcaccgc gcgtaccccc caaacgccaa gaaaacggca catgcgagcc 25320 caacccgcgc ctcaacttct accccgtatt tgccgtgcca gaggtgcttg ccacctatca 25380

catctttttc caaaactgca agatacccct atcctgccgt gccaaccgca gccgagcgga 25440 caagcagctg gccttgcggc agggcgctgt catacctgat atcgcctcgc tcaacgaagt 25500

gccaaaaatc tttgagggtc ttggacgcga cgagaagcgc gcggcaaacg ctctgcaaca 25560 ggaaaacagc gaaaatgaaa gtcactctgg agtgttggtg gaactcgagg gtgacaacgc 25620 gcgcctagcc gtactaaaac gcagcatcga ggtcacccac tttgcctacc cggcacttaa 25680

cctacccccc aaggtcatga gcacagtcat gagtgagctg atcgtgcgcc gtgcgcagcc 25740 Page 104

Sequence_Listing.txt cctggagagg gatgcaaatt tgcaagaaca aacagaggag ggcctacccg cagttggcga 25800

cgagcagcta gcgcgctggc ttcaaacgcg cgagcctgcc gacttggagg agcgacgcaa 25860 actaatgatg gccgcagtgc tcgttaccgt ggagcttgag tgcatgcagc ggttctttgc 25920

tgacccggag atgcagcgca agctagagga aacattgcac tacacctttc gacagggcta 25980 cgtacgccag gcctgcaaga tctccaacgt ggagctctgc aacctggtct cctaccttgg 26040 aattttgcac gaaaaccgcc ttgggcaaaa cgtgcttcat tccacgctca agggcgaggc 26100

gcgccgcgac tacgtccgcg actgcgttta cttatttcta tgctacacct ggcagacggc 26160 catgggcgtt tggcagcagt gcttggagga gtgcaacctc aaggagctgc agaaactgct 26220 aaagcaaaac ttgaaggacc tatggacggc cttcaacgag cgctccgtgg ccgcgcacct 26280

ggcggacatc attttccccg aacgcctgct taaaaccctg caacagggtc tgccagactt 26340 caccagtcaa agcatgttgc agaactttag gaactttatc ctagagcgct caggaatctt 26400 gcccgccacc tgctgtgcac ttcctagcga ctttgtgccc attaagtacc gcgaatgccc 26460

tccgccgctt tggggccact gctaccttct gcagctagcc aactaccttg cctaccactc 26520 tgacataatg gaagacgtga gcggtgacgg tctactggag tgtcactgtc gctgcaacct 26580

atgcaccccg caccgctccc tggtttgcaa ttcgcagctg cttaacgaaa gtcaaattat 26640

cggtaccttt gagctgcagg gtccctcgcc tgacgaaaag tccgcggctc cggggttgaa 26700

actcactccg gggctgtgga cgtcggctta ccttcgcaaa tttgtacctg aggactacca 26760

cgcccacgag attaggttct acgaagacca atcccgcccg cctaatgcgg agcttaccgc 26820 ctgcgtcatt acccagggcc acattcttgg ccaattgcaa gccatcaaca aagcccgcca 26880

agagtttctg ctacgaaagg gacggggggt ttacttggac ccccagtccg gcgaggagct 26940

caacccaatc cccccgccgc cgcagcccta tcagcagcag ccgcgggccc ttgcttccca 27000 ggatggcacc caaaaagaag ctgcagctgc cgccgccacc cacggacgag gaggaatact 27060

gggacagtca ggcagaggag gttttggacg aggaggagga ggacatgatg gaagactggg 27120 agagcctaga cgaggaagct tccgaggtcg aagaggtgtc agacgaaaca ccgtcaccct 27180 cggtcgcatt cccctcgccg gcgccccaga aatcggcaac cggttccagc atggctacaa 27240

cctccgctcc tcaggcgccg ccggcactgc ccgttcgccg acccaaccgt agatgggaca 27300 ccactggaac cagggccggt aagtccaagc agccgccgcc gttagcccaa gagcaacaac 27360 agcgccaagg ctaccgctca tggcgcgggc acaagaacgc catagttgct tgcttgcaag 27420

actgtggggg caacatctcc ttcgcccgcc gctttcttct ctaccatcac ggcgtggcct 27480 tcccccgtaa catcctgcat tactaccgtc atctctacag cccatactgc accggcggca 27540

gcggcagcaa cagcagcggc cacacagaag caaaggcgac cggatagcaa gactctgaca 27600 aagcccaaga aatccacagc ggcggcagca gcaggaggag gagcgctgcg tctggcgccc 27660 aacgaacccg tatcgacccg cgagcttaga aacaggattt ttcccactct gtatgctata 27720

tttcaacaga gcaggggcca agaacaagag ctgaaaataa aaaacaggtc tctgcgatcc 27780 Page 105

Sequence_Listing.txt ctcacccgca gctgcctgta tcacaaaagc gaagatcagc ttcggcgcac gctggaagac 27840

gcggaggctc tcttcagtaa atactgcgcg ctgactctta aggactagtt tcgcgccctt 27900 tctcaaattt aagcgcgaaa actacgtcat ctccagcggc cacacccggc gccagcacct 27960

gtcgtcagcg ccatttcaac tttgtataca aaagttgtga tgagcaagga aattcccacg 28020 ccctacatgt ggagttacca gccacaaatg ggacttgcgg ctggagctgc ccaagactac 28080 tcaacccgaa taaactacat gagcgcggga ccccacatga tatcccgggt caacggaata 28140

cgcgcccacc gaaaccgaat tctcctggaa caggcggcta ttaccaccac acctcgtaat 28200 aaccttaatc cccgtagttg gcccgctgcc ctggtgtacc aggaaagtcc cgctcccacc 28260 actgtggtac ttcccagaga cgcccaggcc gaagttcaga tgactaactc aggggcgcag 28320

cttgcgggcg gctttcgtca cagggtgcgg tcgcccgggc agggtataac tcacctgaca 28380 atcagagggc gaggtattca gctcaacgac gagtcggtga gctcctcgct tggtctccgt 28440 ccggacggga catttcagat cggcggcgcc ggccgctctt cattcacgcc tcgtcaggca 28500

atcctaactc tgcagacctc gtcctctgag ccgcgctctg gaggcattgg aactctgcaa 28560 tttattgagg agtttgtgcc atcggtctac tttaacccct tctcgggacc tcccggccac 28620

tatccggatc aatttattcc taactttgac gcggtaaagg actcggcgga cggctacgac 28680

tgaatgttaa gtggagaggc agagcaactg cgcctgaaac acctggtcca ctgtcgccgc 28740

cacaagtgct ttgcccgcga ctccggtgag ttttgctact ttgaattgcc cgaggatcat 28800

atcgagggcc cggcgcacgg cgtccggctt accgcccagg gagagcttgc ccgtagcctg 28860 attcgggagt ttacccagcg ccccctgcta gttgagcggg acaggggacc ctgtgttctc 28920

actgtgattt gcaactgtcc taaccctgga ttacatcaag atctttgttg ccatctctgt 28980

gctgagtata ataaatacag aaattaaaat atactggggc tcctatcgcc atcctgtaaa 29040 cgccaccgtc ttcacccgcc caagcaaacc aaggcgaacc ttacctggta cttttaacat 29100

ctctccctct gtgatttaca acagtttcaa cccagacgga gtgagtctac gagagaacct 29160 ctccgagctc agctactcca tcagaaaaaa caccaccctc cttacctgcc gggaacgtac 29220 gagtgcgtca ccggccgctg caccacacct accgcctgac cgtaaaccag actttttccg 29280

gacagacctc aataactctg tttaccagaa caggaggtga gcttagaaaa cccttagggt 29340 attaggccaa aggcgcagct actgtggggt ttatgaacaa ttcaagcaac tctacgggct 29400 attctaattc aggtttctct agaatcgggg ttggggttat tctctgtctt gtgattctct 29460

ttattcttat actaacgctt ctctgcctaa ggctcgccgc ctgctgtgtg cacatttgca 29520 tttattgtca gctttttaaa cgctggggtc gccacccaag atgattaggt acataatcct 29580

aggtttactc acccttgcgt cagcccacgg taccacccaa aaggtggatt ttaaggagcc 29640 agcctgtaat gttacattcg cagctgaagc taatgagtgc accactctta taaaatgcac 29700 cacagaacat gaaaagctgc ttattcgcca caaaaacaaa attggcaagt atgctgttta 29760

tgctatttgg cagccaggtg acactacaga gtataatgtt acagttttcc agggtaaaag 29820 Page 106

Sequence_Listing.txt tcataaaact tttatgtata cttttccatt ttatgaaatg tgcgacatta ccatgtacat 29880

gagcaaacag tataagttgt ggcccccaca aaattgtgtg gaaaacactg gcactttctg 29940 ctgcactgct atgctaatta cagtgctcgc tttggtctgt accctactct atattaaata 30000

caaaagcaga cgcagcttta ttgaggaaaa gaaaatgcct taatttacta agttacaaag 30060 ctaatgtcac cactaactgc tttactcgct gcttgcaaaa caaattcaaa aagttagcat 30120 tataattaga ataggattta aaccccccgg tcatttcctg ctcaatacca ttcccctgaa 30180

caattgactc tatgtgggat atgctccagc gctacaacct tgaagtcagg cttcctggat 30240 gtcagcatct gactttggcc agcacctgtc ccgcggattt gttccagtcc aactacagcg 30300 acccacccta acagagatga ccaacacaac caacgcggcc gccgctaccg gacttacatc 30360

taccacaaat acaccccaag tttctgcctt tgtcaataac tgggataact tgggcatgtg 30420 gtggttctcc atagcgctta tgtttgtatg ccttattatt atgtggctca tctgctgcct 30480 aaagcgcaaa cgcgcccgac cacccatcta tagtcccatc attgtgctac acccaaacaa 30540

tgatggaatc catagattgg acggactgaa acacatgttc ttttctctta cagtatgatt 30600 aaatgagaca tgattcctcg agtttttata ttactgaccc ttgttgcgct tttttgtgcg 30660

tgctccacat tggctgcggt ttctcacatc gaagtagact gcattccagc cttcacagtc 30720

tatttgcttt acggatttgt caccctcacg ctcatctgca gcctcatcac tgtggtcatc 30780

gcctttatcc agtgcattga ctgggtctgt gtgcgctttg catatctcag acaccatccc 30840

cagtacaggg acaggactat agctgagctt cttagaattc tttaattatg aaatttactg 30900 tgacttttct gctgattatt tgcaccctat ctgcgttttg ttccccgacc tccaagcctc 30960

aaagacatat atcatgcaga ttcactcgta tatggaatat tccaagttgc tacaatgaaa 31020

aaagcgatct ttccgaagcc tggttatatg caatcatctc tgttatggtg ttctgcagta 31080 ccatcttagc cctagctata tatccctacc ttgacattgg ctggaacgca atagatgcca 31140

tgaaccaccc aactttcccc gcgcccgcta tgcttccact gcaacaagtt gttgccggcg 31200 gctttgtccc agccaatcag cctcgcccac cttctcccac ccccactgaa atcagctact 31260 ttaatctaac aggaggagat gactgacacc ctagatctag aaatggacgg aattattaca 31320

gagcagcgcc tgctagaaag acgcagggca gcggccgagc aacagcgcat gaatcaagag 31380 ctccaagaca tggttaactt gcaccagtgc aaaaggggta tcttttgtct ggtaaagcag 31440 gccaaagtca cctacgacag taataccacc ggacaccgcc ttagctacaa gttgccaacc 31500

aagcgtcaga aattggtggt catggtggga gaaaagccca ttaccataac tcagcactcg 31560 gtagaaaccg aaggctgcat tcactcacct tgtcaaggac ctgaggatct ctgcaccctt 31620

attaagaccc tgtgcggtct caaagatctt attcccttta actaataaaa aaaaataata 31680 aagcatcact tacttaaaat cagttagcaa atttctgtcc agtttattca gcagcacctc 31740 cttgccctcc tcccagctct ggtattgcag cttcctcctg gctgcaaact ttctccacaa 31800

tctaaatgga atgtcagttt cctcctgttc ctgtccatcc gcacccacta tcttcatgtt 31860 Page 107

Sequence_Listing.txt gttgcagatg aagcgcgcaa gaccgtctga agataccttc aaccccgtgt atccatatga 31920

cacggaaacc ggtcctccaa ctgtgccttt tcttactcct ccctttgtat cccccaatgg 31980 gtttcaagag agtccccctg gggtactctc tttgcgccta tccgaacctc tagttacctc 32040

caatggcatg cttgcgctca aaatgggcaa cggcctctct ctggacgagg ccggcaacct 32100 tacctcccaa aatgtaacca ctgtgagccc acctctcaaa aaaaccaagt caaacataaa 32160 cctggaaata tctgcacccc tcacagttac ctcagaagcc ctaactgtgg ctgccgccgc 32220

acctctaatg gtcgcgggca acacactcac catgcaatca caggccccgc taaccgtgca 32280 cgactccaaa cttagcattg ccacccaagg acccctcaca gtgtcagaag gaaagctagc 32340 cctgcaaaca tcaggccccc tcaccaccac cgatagcagt acccttacta tcactgcctc 32400

accccctcta actactgcca ctggtagctt gggcattgac ttgaaagagc ccatttatac 32460 acaaaatgga aaactaggac taaagtacgg ggctcctttg catgtaacag acgacctaaa 32520 cactttgacc gtagcaactg gtccaggtgt gactattaat aatacttcct tgcaaactaa 32580

agttactgga gccttgggtt ttgattcaca aggcaatatg caacttaatg tagcaggagg 32640 actaaggatt gattctcaaa acagacgcct tatacttgat gttagttatc cgtttgatgc 32700

tcaaaaccaa ctaaatctaa gactaggaca gggccctctt tttataaact cagcccacaa 32760

cttggatatt aactacaaca aaggccttta cttgtttaca gcttcaaaca attccaaaaa 32820

gcttgaggtt aacctaagca ctgccaaggg gttgatgttt gacgctacag ccatagccat 32880

taatgcagga gatgggcttg aatttggttc acctaatgca ccaaacacaa atcccctcaa 32940 aacaaaaatt ggccatggcc tagaatttga ttcaaacaag gctatggttc ctaaactagg 33000

aactggcctt agttttgaca gcacaggtgc cattacagta ggaaacaaaa ataatgataa 33060

gctaactttg tggaccacac cagctccatc tcctaactgt agactaaatg cagagaaaga 33120 tgctaaactc actttggtct taacaaaatg tggcagtcaa atacttgcta cagtttcagt 33180

tttggctgtt aaaggcagtt tggctccaat atctggaaca gttcaaagtg ctcatcttat 33240 tataagattt gacgaaaatg gagtgctact aaacaattcc ttcctggacc cagaatattg 33300 gaactttaga aatggagatc ttactgaagg cacagcctat acaaacgctg ttggatttat 33360

gcctaaccta tcagcttatc caaaatctca cggtaaaact gccaaaagta acattgtcag 33420 tcaagtttac ttaaacggag acaaaactaa acctgtaaca ctaaccatta cactaaacgg 33480 tacacaggaa acaggagaca caactccaag tgcatactct atgtcatttt catgggactg 33540

gtctggccac aactacatta atgaaatatt tgccacatcc tcttacactt tttcatacat 33600 tgcccaagaa taaagaatcg tttgtgttat gtttcaacgt gtttattttt caattgcaga 33660

aaatttcgaa tcatttttca ttcagtagta tagccccacc accacatagc ttatacagat 33720 caccgtacct caactttgta taataaagtt gtaatcaaac tcacagaacc ctagtattca 33780 acctgccacc tccctcccaa cacacagagt acacagtcct ttctccccgg ctggccttaa 33840

aaagcatcat atcatgggta acagacatat tcttaggtgt tatattccac acggtttcct 33900 Page 108

Sequence_Listing.txt gtcgagccaa acgctcatca gtgatattaa taaactcccc gggcagctca cttaagttca 33960

tgtcgctgtc cagctgctga gccacaggct gctgtccaac ttgcggttgc ttaacgggcg 34020 gcgaaggaga agtccacgcc tacatggggg tagagtcata atcgtgcatc aggatagggc 34080

ggtggtgctg cagcagcgcg cgaataaact gctgccgccg ccgctccgtc ctgcaggaat 34140 acaacatggc agtggtctcc tcagcgatga ttcgcaccgc ccgcagcata aggcgccttg 34200 tcctccgggc acagcagcgc accctgatct cacttaaatc agcacagtaa ctgcagcaca 34260

gcaccacaat attgttcaaa atcccacagt gcaaggcgct gtatccaaag ctcatggcgg 34320 ggaccacaga acccacgtgg ccatcatacc acaagcgcag gtagattaag tggcgacccc 34380 tcataaacac gctggacata aacattacct cttttggcat gttgtaattc accacctccc 34440

ggtaccatat aaacctctga ttaaacatgg cgccatccac caccatccta aaccagctgg 34500 ccaaaacctg cccgccggct atacactgca gggaaccggg actggaacaa tgacagtgga 34560 gagcccagga ctcgtaacca tggatcatca tgctcgtcat gatatcaatg ttggcacaac 34620

acaggcacac gtgcatacac ttcctcagga ttacaagctc ctcccgcgtt agaaccatat 34680 cccagggaac aacccattcc tgaatcagcg taaatcccac actgcaggga agacctcgca 34740

cgtaactcac gttgtgcatt gtcaaagtgt tacattcggg cagcagcgga tgatcctcca 34800

gtatggtagc gcgggtttct gtctcaaaag gaggtagacg atccctactg tacggagtgc 34860

gccgagacaa ccgagatcgt gttggtcgta gtgtcatgcc aaatggaacg ccggacgtag 34920

tcatatttcc tgaagcaaaa ccaggtgcgg gcgtgacaaa cagatctgcg tctccggtct 34980 cgccgcttag atcgctctgt gtagtagttg tagtatatcc actctctcaa agcatccagg 35040

cgccccctgg cttcgggttc tatgtaaact ccttcatgcg ccgctgccct gataacatcc 35100

accaccgcag aataagccac acccagccaa cctacacatt cgttctgcga gtcacacacg 35160 ggaggagcgg gaagagctgg aagaaccatg tttttttttt tattccaaaa gattatccaa 35220

aacctcaaaa tgaagatcta ttaagtgaac gcgctcccct ccggtggcgt ggtcaaactc 35280 tacagccaaa gaacagataa tggcatttgt aagatgttgc acaatggctt ccaaaaggca 35340 aacggccctc acgtccaagt ggacgtaaag gctaaaccct tcagggtgaa tctcctctat 35400

aaacattcca gcaccttcaa ccatgcccaa ataattctca tctcgccacc ttctcaatat 35460 atctctaagc aaatcccgaa tattaagtcc ggccattgta aaaatctgct ccagagcgcc 35520 ctccaccttc agcctcaagc agcgaatcat gattgcaaaa attcaggttc ctcacagacc 35580

tgtataagat tcaaaagcgg aacattaaca aaaataccgc gatcccgtag gtcccttcgc 35640 agggccagct gaacataatc gtgcaggtct gcacggacca gcgcggccac ttccccgcca 35700

ggaaccatga caaaagaacc cacactgatt atgacacgca tactcggagc tatgctaacc 35760 agcgtagccc cgatgtaagc ttgttgcatg ggcggcgata taaaatgcaa ggtgctgctc 35820 aaaaaatcag gcaaagcctc gcgcaaaaaa gaaagcacat cgtagtcatg ctcatgcaga 35880

taaaggcagg taagctccgg aaccaccaca gaaaaagaca ccatttttct ctcaaacatg 35940 Page 109

Sequence_Listing.txt tctgcgggtt tctgcataaa cacaaaataa aataacaaaa aaacatttaa acattagaag 36000

cctgtcttac aacaggaaaa acaaccctta taagcataag acggactacg gccatgccgg 36060 cgtgaccgta aaaaaactgg tcaccgtgat taaaaagcac caccgacagc tcctcggtca 36120

tgtccggagt cataatgtaa gactcggtaa acacatcagg ttgattcaca tcggtcagtg 36180 ctaaaaagcg accgaaatag cccgggggaa tacatacccg caggcgtaga gacaacatta 36240 cagcccccat aggaggtata acaaaattaa taggagagaa aaacacataa acacctgaaa 36300

aaccctcctg cctaggcaaa atagcaccct cccgctccag aacaacatac agcgcttcca 36360 cagcggcagc cataacagtc agccttacca gtaaaaaaga aaacctatta aaaaaacacc 36420 actcgacacg gcaccagctc aatcagtcac agtgtaaaaa agggccaagt gcagagcgag 36480

tatatatagg actaaaaaat gacgtaacgg ttaaagtcca caaaaaacac ccagaaaacc 36540 gcacgcgaac ctacgcccag aaacgaaagc caaaaaaccc acaacttcct caaatcgtca 36600 cttccgtttt cccacgttac gtcacttccc attttaagaa aactacaatt cccaacacat 36660

acaagttact ccgccctaaa acctacgtca cccgccccgt tcccacgccc cgcgccacgt 36720 cacaaactcc accccctcat tatcatattg gcttcaatcc aaaataaggt atattattga 36780

tgatg 36785

<210> 7 <211> 36797 <212> DNA <213> Artificial Sequence <220> <223> Synthetic adenovirus genome YPet-P2A-ADP <400> 7 catcatcaat aatatacctt attttggatt gaagccaata tgataatgag ggggtggagt 60 ttgtgacgtg gcgcggggcg tgggaacggg gcgggtgacg tagtagtgtg gcggaagtgt 120

gatgttgcaa gtgtggcgga acacatgtaa gcgacggatg tggcaaaagt gacgtttttg 180 gtgtgcgccg gtgtacacag gaagtgacaa ttttcgcgcg gttttaggcg gatgttgtag 240 taaatttggg cgtaaccgag taagatttgg ccattttcgc gggaaaactg aataagagga 300

agtgaaatct gaataatttt gtgttactca tagcgcgtaa tatttgtcta gggccgcggg 360 gactttgacc gtttacgtgg agactcgccc aggtgttttt ctcaggtgtt ttccgcgttc 420 cgggtcaaag ttggcgtttt attattatag tcagctgacg tgtagtgtat ttatacccgg 480

tgagttcctc aagaggccac tcttgagtgc cagcgagtag agttttctcc tccgagccgc 540 tccgacaccg ggactgaaaa tgagacatat tatctgccac ggaggtgtta ttaccgaaga 600

aatggccgcc agtcttttgg accagctgat cgaagaggta ctggctgata atcttccacc 660 tcctagccat tttgaaccac ctacccttca cgaactgtat gatttagacg tgacggcccc 720 cgaagatccc aacgaggagg cggtttcgca gatttttccc gactctgtaa tgttggcggt 780

gcaggaaggg attgacttac tcacttttcc gccggcgccc ggttctccgg agccgcctca 840 Page 110

Sequence_Listing.txt cctttcccgg cagcccgagc agccggagca gagagccttg ggtccggttt ctatgccaaa 900

ccttgtaccg gaggtgatcg atcttacctg ccacgaggct ggctttccac ccagtgacga 960 cgaggatgaa gagggtgagg agtttgtgtt agattatgtg gagcaccccg ggcacggttg 1020

caggtcttgt cattatcacc ggaggaatac gggggaccca gatattatgt gttcgctttg 1080 ctatatgagg acctgtggca tgtttgtcta cagtaagtga aaattatggg cagtgggtga 1140 tagagtggtg ggtttggtgt ggtaattttt tttttaattt ttacagtttt gtggtttaaa 1200

gaattttgta ttgtgatttt tttaaaaggt cctgtgtctg aacctgagcc tgagcccgag 1260 ccagaaccgg agcctgcaag acctacccgc cgtcctaaaa tggcgcctgc tatcctgaga 1320 cgcccgacat cacctgtgtc tagagaatgc aatagtagta cggatagctg tgactccggt 1380

ccttctaaca cacctcctga gatacacccg gtggtcccgc tgtgccccat taaaccagtt 1440 gccgtgagag ttggtgggcg tcgccaggct gtggaatgta tcgaggactt gcttaacgag 1500 cctgggcaac ctttggactt gagctgtaaa cgccccaggc cataaggtgt aaacctgtga 1560

ttgcgtgtgt ggttaacgcc tttgtttgct gaatgagttg atgtaagttt aataaagggt 1620 gagataatgt ttaacttgca tggcgtgtta aatggggcgg ggcttaaagg gtatataatg 1680

cgccgtgggc taatcttggt tacatctgac ctcatggagg cttgggagtg tttggaagat 1740

ttttctgctg tgcgtaactt gctggaacag agctctaaca gtacctcttg gttttggagg 1800

tttctgtggg gctcatccca ggcaaagtta gtctgcagaa ttaaggagga ttacaagtgg 1860

gaatttgaag agcttttgaa atcctgtggt gagctgtttg attctttgaa tctgggtcac 1920 caggcgcttt tccaagagaa ggtcatcaag actttggatt tttccacacc ggggcgcgct 1980

gcggctgctg ttgctttttt gagttttata aaggataaat ggagcgaaga aacccatctg 2040

agcggggggt acctgctgga ttttctggcc atgcatctgt ggagagcggt tgtgagacac 2100 aagaatcgcc tgctactgtt gtcttccgtc cgcccggcga taataccgac ggaggagcag 2160

cagcagcagc aggaggaagc caggcggcgg cggcaggagc agagcccatg gaacccgaga 2220 gccggcctgg accctcggga atgaatgttg tacaggtggc tgaactgtat ccagaactga 2280 gacgcatttt gacaattaca gaggatgggc aggggctaaa gggggtaaag agggagcggg 2340

gggcttgtga ggctacagag gaggctagga atctagcttt tagcttaatg accagacacc 2400 gtcctgagtg tattactttt caacagatca aggataattg cgctaatgag cttgatctgc 2460 tggcgcagaa gtattccata gagcagctga ccacttactg gctgcagcca ggggatgatt 2520

ttgaggaggc tattagggta tatgcaaagg tggcacttag gccagattgc aagtacaaga 2580 tcagcaaact tgtaaatatc aggaattgtt gctacatttc tgggaacggg gccgaggtgg 2640

agatagatac ggaggatagg gtggccttta gatgtagcat gataaatatg tggccggggg 2700 tgcttggcat ggacggggtg gttattatga atgtaaggtt tactggcccc aattttagcg 2760 gtacggtttt cctggccaat accaacctta tcctacacgg tgtaagcttc tatgggttta 2820

acaatacctg tgtggaagcc tggaccgatg taagggttcg gggctgtgcc ttttactgct 2880 Page 111

Sequence_Listing.txt gctggaaggg ggtggtgtgt cgccccaaaa gcagggcttc aattaagaaa tgcctctttg 2940

aaaggtgtac cttgggtatc ctgtctgagg gtaactccag ggtgcgccac aatgtggcct 3000 ccgactgtgg ttgcttcatg ctagtgaaaa gcgtggctgt gattaagcat aacatggtat 3060

gtggcaactg cgaggacagg gcctctcaga tgctgacctg ctcggacggc aactgtcacc 3120 tgctgaagac cattcacgta gccagccact ctcgcaaggc ctggccagtg tttgagcata 3180 acatactgac ccgctgttcc ttgcatttgg gtaacaggag gggggtgttc ctaccttacc 3240

aatgcaattt gagtcacact aagatattgc ttgagcccga gagcatgtcc aaggtgaacc 3300 tgaacggggt gtttgacatg accatgaaga tctggaaggt gctgaggtac gatgagaccc 3360 gcaccaggtg cagaccctgc gagtgtggcg gtaaacatat taggaaccag cctgtgatgc 3420

tggatgtgac cgaggagctg aggcccgatc acttggtgct ggcctgcacc cgcgctgagt 3480 ttggctctag cgatgaagat acagattgag gtactgaaat gtgtgggcgt ggcttaaggg 3540 tgggaaagaa tatataaggt gggggtctta tgtagttttg tatctgtttt gcagcagccg 3600

ccgccgccca acttttctat acaaagttgt aatgagcacc aactcgtttg atggaagcat 3660 tgtgagctca tatttgacaa cgcgcatgcc cccatgggcc ggggtgcgtc agaatgtgat 3720

gggctccagc attgatggtc gccccgtcct gcccgcaaac tctactacct tgacctacga 3780

gaccgtgtct ggaacgccgt tggagactgc agcctccgcc gccgcttcag ccgctgcagc 3840

caccgcccgc gggattgtga ctgactttgc tttcctgagc ccgcttgcaa gcagtgcagc 3900

ttcccgttca tccgcccgcg atgacaagtt gacggctctt ttggcacaat tggattcttt 3960 gacccgggaa cttaatgtcg tttctcagca gctgttggat ctgcgccagc aggtttctgc 4020

cctgaaggct tcctcccctc ccaatgcggt ttaaaacata aataaaaaac cagactctgt 4080

ttggatttgg atcaagcata agtgtcttgc tgtctttatt taggggtttt gcgcgcgcgg 4140 taggcccggg accagcggtc tcggtcgttg agggtcctgt gtattttttc caggacgtgg 4200

taaaggtgac tctggatgtt cagatacatg ggcataagcc cgtctctggg gtggaggtag 4260 caccactgca gagcttcatg ctgcggggtg gtgttgtaga tgatccagtc gtagcaggag 4320 cgctgggcgt ggtgcctaaa aatgtctttc agtagcaagc tgattgccag gggcaggccc 4380

ttggtgtaag tgtttacaaa gcggttaagc tgggatgggt gcatacgtgg ggatatgaga 4440 tgcatcttgg actgtatttt taggttggct atgttcccag ccatatccct ccggggattc 4500 atgttgtgca gaaccaccag cacagtgtat ccggtgcact tgggaaattt gtcatgtagc 4560

ttagaaggaa atgcgtggaa gaacttggag acgcccttgt gacctccaag attttccatg 4620 cattcgtcca taatgatggc aatgggccca cgggcggcgg cctgggcgaa gatatttctg 4680

ggatcactaa cgtcatagtt gtgttccagg atgagatcgt cataggccat ttttacaaag 4740 cgcgggcgga gggtgccaga ctgcggtata atggttccat ccggcccagg ggcgtagtta 4800 ccctcacaga tttgcatttc ccacgctttg agttcagatg gggggatcat gtctacctgc 4860

ggggcgatga agaaaacggt ttccggggta ggggagatca gctgggaaga aagcaggttc 4920 Page 112

Sequence_Listing.txt ctgagcagct gcgacttacc gcagccggtg ggcccgtaaa tcacacctat taccgggtgc 4980

aactggtagt taagagagct gcagctgccg tcatccctga gcaggggggc cacttcgtta 5040 agcatgtccc tgactcgcat gttttccctg accaaatccg ccagaaggcg ctcgccgccc 5100

agcgatagca gttcttgcaa ggaagcaaag tttttcaacg gtttgagacc gtccgccgta 5160 ggcatgcttt tgagcgtttg accaagcagt tccaggcggt cccacagctc ggtcacctgc 5220 tctacggcat ctcgatccag catatctcct cgtttcgcgg gttggggcgg ctttcgctgt 5280

acggcagtag tcggtgctcg tccagacggg ccagggtcat gtctttccac gggcgcaggg 5340 tcctcgtcag cgtagtctgg gtcacggtga aggggtgcgc tccgggctgc gcgctggcca 5400 gggtgcgctt gaggctggtc ctgctggtgc tgaagcgctg ccggtcttcg ccctgcgcgt 5460

cggccaggta gcatttgacc atggtgtcat agtccagccc ctccgcggcg tggcccttgg 5520 cgcgcagctt gcccttggag gaggcgccgc acgaggggca gtgcagactt ttgagggcgt 5580 agagcttggg cgcgagaaat accgattccg gggagtaggc atccgcgccg caggccccgc 5640

agacggtctc gcattccacg agccaggtga gctctggccg ttcggggtca aaaaccaggt 5700 ttcccccatg ctttttgatg cgtttcttac ctctggtttc catgagccgg tgtccacgct 5760

cggtgacgaa aaggctgtcc gtgtccccgt atacagactt gagaggcctg tcctcgagcg 5820

gtgttccgcg gtcctcctcg tatagaaact cggaccactc tgagacaaag gctcgcgtcc 5880

aggccagcac gaaggaggct aagtgggagg ggtagcggtc gttgtccact agggggtcca 5940

ctcgctccag ggtgtgaaga cacatgtcgc cctcttcggc atcaaggaag gtgattggtt 6000 tgtaggtgta ggccacgtga ccgggtgttc ctgaaggggg gctataaaag ggggtggggg 6060

cgcgttcgtc ctcactctct tccgcatcgc tgtctgcgag ggccagctgt tggggtgagt 6120

actccctctg aaaagcgggc atgacttctg cgctaagatt gtcagtttcc aaaaacgagg 6180 aggatttgat attcacctgg cccgcggtga tgcctttgag ggtggccgca tccatctggt 6240

cagaaaagac aatctttttg ttgtcaagct tggtggcaaa cgacccgtag agggcgttgg 6300 acagcaactt ggcgatggag cgcagggttt ggtttttgtc gcgatcggcg cgctccttgg 6360 ccgcgatgtt tagctgcacg tattcgcgcg caacgcaccg ccattcggga aagacggtgg 6420

tgcgctcgtc gggcaccagg tgcacgcgcc aaccgcggtt gtgcagggtg acaaggtcaa 6480 cgctggtggc tacctctccg cgtaggcgct cgttggtcca gcagaggcgg ccgcccttgc 6540 gcgagcagaa tggcggtagg gggtctagct gcgtctcgtc cggggggtct gcgtccacgg 6600

taaagacccc gggcagcagg cgcgcgtcga agtagtctat cttgcatcct tgcaagtcta 6660 gcgcctgctg ccatgcgcgg gcggcaagcg cgcgctcgta tgggttgagt gggggacccc 6720

atggcatggg gtgggtgagc gcggaggcgt acatgccgca aatgtcgtaa acgtagaggg 6780 gctctctgag tattccaaga tatgtagggt agcatcttcc accgcggatg ctggcgcgca 6840 cgtaatcgta tagttcgtgc gagggagcga ggaggtcggg accgaggttg ctacgggcgg 6900

gctgctctgc tcggaagact atctgcctga agatggcatg tgagttggat gatatggttg 6960 Page 113

Sequence_Listing.txt gacgctggaa gacgttgaag ctggcgtctg tgagacctac cgcgtcacgc acgaaggagg 7020

cgtaggagtc gcgcagcttg ttgaccagct cggcggtgac ctgcacgtct agggcgcagt 7080 agtccagggt ttccttgatg atgtcatact tatcctgtcc cttttttttc cacagctcgc 7140

ggttgaggac aaactcttcg cggtctttcc agtactcttg gatcggaaac ccgtcggcct 7200 ccgaacggta agagcctagc atgtagaact ggttgacggc ctggtaggcg cagcatccct 7260 tttctacggg tagcgcgtat gcctgcgcgg ccttccggag cgaggtgtgg gtgagcgcaa 7320

aggtgtccct gaccatgact ttgaggtact ggtatttgaa gtcagtgtcg tcgcatccgc 7380 cctgctccca gagcaaaaag tccgtgcgct ttttggaacg cggatttggc agggcgaagg 7440 tgacatcgtt gaagagtatc tttcccgcgc gaggcataaa gttgcgtgtg atgcggaagg 7500

gtcccggcac ctcggaacgg ttgttaatta cctgggcggc gagcacgatc tcgtcaaagc 7560 cgttgatgtt gtggcccaca atgtaaagtt ccaagaagcg cgggatgccc ttgatggaag 7620 gcaatttttt aagttcctcg taggtgagct cttcagggga gctgagcccg tgctctgaaa 7680

gggcccagtc tgcaagatga gggttggaag cgacgaatga gctccacagg tcacgggcca 7740 ttagcatttg caggtggtcg cgaaaggtcc taaactggcg acctatggcc attttttctg 7800

gggtgatgca gtagaaggta agcgggtctt gttcccagcg gtcccatcca aggttcgcgg 7860

ctaggtctcg cgcggcagtc actagaggct catctccgcc gaacttcatg accagcatga 7920

agggcacgag ctgcttccca aaggccccca tccaagtata ggtctctaca tcgtaggtga 7980

caaagagacg ctcggtgcga ggatgcgagc cgatcgggaa gaactggatc tcccgccacc 8040 aattggagga gtggctattg atgtggtgaa agtagaagtc cctgcgacgg gccgaacact 8100

cgtgctggct tttgtaaaaa cgtgcgcagt actggcagcg gtgcacgggc tgtacatcct 8160

gcacgaggtt gacctgacga ccgcgcacaa ggaagcagag tgggaatttg agcccctcgc 8220 ctggcgggtt tggctggtgg tcttctactt cggctgcttg tccttgaccg tctggctgct 8280

cgaggggagt tacggtggat cggaccacca cgccgcgcga gcccaaagtc cagatgtccg 8340 cgcgcggcgg tcggagcttg atgacaacat cgcgcagatg ggagctgtcc atggtctgga 8400 gctcccgcgg cgtcaggtca ggcgggagct cctgcaggtt tacctcgcat agacgggtca 8460

gggcgcgggc tagatccagg tgatacctaa tttccagggg ctggttggtg gcggcgtcga 8520 tggcttgcaa gaggccgcat ccccgcggcg cgactacggt accgcgcggc gggcggtggg 8580 ccgcgggggt gtccttggat gatgcatcta aaagcggtga cgcgggcgag cccccggagg 8640

tagggggggc tccggacccg ccgggagagg gggcaggggc acgtcggcgc cgcgcgcggg 8700 caggagctgg tgctgcgcgc gtaggttgct ggcgaacgcg acgacgcggc ggttgatctc 8760

ctgaatctgg cgcctctgcg tgaagacgac gggcccggtg agcttgagcc tgaaagagag 8820 ttcgacagaa tcaatttcgg tgtcgttgac ggcggcctgg cgcaaaatct cctgcacgtc 8880 tcctgagttg tcttgatagg cgatctcggc catgaactgc tcgatctctt cctcctggag 8940

atctccgcgt ccggctcgct ccacggtggc ggcgaggtcg ttggaaatgc gggccatgag 9000 Page 114

Sequence_Listing.txt ctgcgagaag gcgttgaggc ctccctcgtt ccagacgcgg ctgtagacca cgcccccttc 9060

ggcatcgcgg gcgcgcatga ccacctgcgc gagattgagc tccacgtgcc gggcgaagac 9120 ggcgtagttt cgcaggcgct gaaagaggta gttgagggtg gtggcggtgt gttctgccac 9180

gaagaagtac ataacccagc gtcgcaacgt ggattcgttg atatccccca aggcctcaag 9240 gcgctccatg gcctcgtaga agtccacggc gaagttgaaa aactgggagt tgcgcgccga 9300 cacggttaac tcctcctcca gaagacggat gagctcggcg acagtgtcgc gcacctcgcg 9360

ctcaaaggct acaggggcct cttcttcttc ttcaatctcc tcttccataa gggcctcccc 9420 ttcttcttct tctggcggcg gtgggggagg ggggacacgg cggcgacgac ggcgcaccgg 9480 gaggcggtcg acaaagcgct cgatcatctc cccgcggcga cggcgcatgg tctcggtgac 9540

ggcgcggccg ttctcgcggg ggcgcagttg gaagacgccg cccgtcatgt cccggttatg 9600 ggttggcggg gggctgccat gcggcaggga tacggcgcta acgatgcatc tcaacaattg 9660 ttgtgtaggt actccgccgc cgagggacct gagcgagtcc gcatcgaccg gatcggaaaa 9720

cctctcgaga aaggcgtcta accagtcaca gtcgcaaggt aggctgagca ccgtggcggg 9780 cggcagcggg cggcggtcgg ggttgtttct ggcggaggtg ctgctgatga tgtaattaaa 9840

gtaggcggtc ttgagacggc ggatggtcga cagaagcacc atgtccttgg gtccggcctg 9900

ctgaatgcgc aggcggtcgg ccatgcccca ggcttcgttt tgacatcggc gcaggtcttt 9960

gtagtagtct tgcatgagcc tttctaccgg cacttcttct tctccttcct cttgtcctgc 10020

atctcttgca tctatcgctg cggcggcggc ggagtttggc cgtaggtggc gccctcttcc 10080 tcccatgcgt gtgaccccga agcccctcat cggctgaagc agggctaggt cggcgacaac 10140

gcgctcggct aatatggcct gctgcacctg cgtgagggta gactggaagt catccatgtc 10200

cacaaagcgg tggtatgcgc ccgtgttgat ggtgtaagtg cagttggcca taacggacca 10260 gttaacggtc tggtgacccg gctgcgagag ctcggtgtac ctgagacgcg agtaagccct 10320

cgagtcaaat acgtagtcgt tgcaagtccg caccaggtac tggtatccca ccaaaaagtg 10380 cggcggcggc tggcggtaga ggggccagcg tagggtggcc ggggctccgg gggcgagatc 10440 ttccaacata aggcgatgat atccgtagat gtacctggac atccaggtga tgccggcggc 10500

ggtggtggag gcgcgcggaa agtcgcggac gcggttccag atgttgcgca gcggcaaaaa 10560 gtgctccatg gtcgggacgc tctggccggt caggcgcgcg caatcgttga cgctctagac 10620 cgtgcaaaag gagagcctgt aagcgggcac tcttccgtgg tctggtggat aaattcgcaa 10680

gggtatcatg gcggacgacc ggggttcgag ccccgtatcc ggccgtccgc cgtgatccat 10740 gcggttaccg cccgcgtgtc gaacccaggt gtgcgacgtc agacaacggg ggagtgctcc 10800

ttttggcttc cttccaggcg cggcggctgc tgcgctagct tttttggcca ctggccgcgc 10860 gcagcgtaag cggttaggct ggaaagcgaa agcattaagt ggctcgctcc ctgtagccgg 10920 agggttattt tccaagggtt gagtcgcggg acccccggtt cgagtctcgg accggccgga 10980

ctgcggcgaa cgggggtttg cctccccgtc atgcaagacc ccgcttgcaa attcctccgg 11040 Page 115

Sequence_Listing.txt aaacagggac gagccccttt tttgcttttc ccagatgcat ccggtgctgc ggcagatgcg 11100

cccccctcct cagcagcggc aagagcaaga gcagcggcag acatgcaggg caccctcccc 11160 tcctcctacc gcgtcaggag gggcgacatc cgcggttgac gcggcagcag atggtgatta 11220

cgaacccccg cggcgccggg cccggcacta cctggacttg gaggagggcg agggcctggc 11280 gcggctagga gcgccctctc ctgagcggta cccaagggtg cagctgaagc gtgatacgcg 11340 tgaggcgtac gtgccgcggc agaacctgtt tcgcgaccgc gagggagagg agcccgagga 11400

gatgcgggat cgaaagttcc acgcagggcg cgagctgcgg catggcctga atcgcgagcg 11460 gttgctgcgc gaggaggact ttgagcccga cgcgcgaacc gggattagtc ccgcgcgcgc 11520 acacgtggcg gccgccgacc tggtaaccgc atacgagcag acggtgaacc aggagattaa 11580

ctttcaaaaa agctttaaca accacgtgcg tacgcttgtg gcgcgcgagg aggtggctat 11640 aggactgatg catctgtggg actttgtaag cgcgctggag caaaacccaa atagcaagcc 11700 gctcatggcg cagctgttcc ttatagtgca gcacagcagg gacaacgagg cattcaggga 11760

tgcgctgcta aacatagtag agcccgaggg ccgctggctg ctcgatttga taaacatcct 11820 gcagagcata gtggtgcagg agcgcagctt gagcctggct gacaaggtgg ccgccatcaa 11880

ctattccatg cttagcctgg gcaagtttta cgcccgcaag atataccata ccccttacgt 11940

tcccatagac aaggaggtaa agatcgaggg gttctacatg cgcatggcgc tgaaggtgct 12000

taccttgagc gacgacctgg gcgtttatcg caacgagcgc atccacaagg ccgtgagcgt 12060

gagccggcgg cgcgagctca gcgaccgcga gctgatgcac agcctgcaaa gggccctggc 12120 tggcacgggc agcggcgata gagaggccga gtcctacttt gacgcgggcg ctgacctgcg 12180

ctgggcccca agccgacgcg ccctggaggc agctggggcc ggacctgggc tggcggtggc 12240

acccgcgcgc gctggcaacg tcggcggcgt ggaggaatat gacgaggacg atgagtacga 12300 gccagaggac ggcgagtact aagcggtgat gtttctgatc agatgatgca agacgcaacg 12360

gacccggcgg tgcgggcggc gctgcagagc cagccgtccg gccttaactc cacggacgac 12420 tggcgccagg tcatggaccg catcatgtcg ctgactgcgc gcaatcctga cgcgttccgg 12480 cagcagccgc aggccaaccg gctctccgca attctggaag cggtggtccc ggcgcgcgca 12540

aaccccacgc acgagaaggt gctggcgatc gtaaacgcgc tggccgaaaa cagggccatc 12600 cggcccgacg aggccggcct ggtctacgac gcgctgcttc agcgcgtggc tcgttacaac 12660 agcggcaacg tgcagaccaa cctggaccgg ctggtggggg atgtgcgcga ggccgtggcg 12720

cagcgtgagc gcgcgcagca gcagggcaac ctgggctcca tggttgcact aaacgccttc 12780 ctgagtacac agcccgccaa cgtgccgcgg ggacaggagg actacaccaa ctttgtgagc 12840

gcactgcggc taatggtgac tgagacaccg caaagtgagg tgtaccagtc tgggccagac 12900 tattttttcc agaccagtag acaaggcctg cagaccgtaa acctgagcca ggctttcaaa 12960 aacttgcagg ggctgtgggg ggtgcgggct cccacaggcg accgcgcgac cgtgtctagc 13020

ttgctgacgc ccaactcgcg cctgttgctg ctgctaatag cgcccttcac ggacagtggc 13080 Page 116

Sequence_Listing.txt agcgtgtccc gggacacata cctaggtcac ttgctgacac tgtaccgcga ggccataggt 13140

caggcgcatg tggacgagca tactttccag gagattacaa gtgtcagccg cgcgctgggg 13200 caggaggaca cgggcagcct ggaggcaacc ctaaactacc tgctgaccaa ccggcggcag 13260

aagatcccct cgttgcacag tttaaacagc gaggaggagc gcattttgcg ctacgtgcag 13320 cagagcgtga gccttaacct gatgcgcgac ggggtaacgc ccagcgtggc gctggacatg 13380 accgcgcgca acatggaacc gggcatgtat gcctcaaacc ggccgtttat caaccgccta 13440

atggactact tgcatcgcgc ggccgccgtg aaccccgagt atttcaccaa tgccatcttg 13500 aacccgcact ggctaccgcc ccctggtttc tacaccgggg gattcgaggt gcccgagggt 13560 aacgatggat tcctctggga cgacatagac gacagcgtgt tttccccgca accgcagacc 13620

ctgctagagt tgcaacagcg cgagcaggca gaggcggcgc tgcgaaagga aagcttccgc 13680 aggccaagca gcttgtccga tctaggcgct gcggccccgc ggtcagatgc tagtagccca 13740 tttccaagct tgatagggtc tcttaccagc actcgcacca cccgcccgcg cctgctgggc 13800

gaggaggagt acctaaacaa ctcgctgctg cagccgcagc gcgaaaaaaa cctgcctccg 13860 gcatttccca acaacgggat agagagccta gtggacaaga tgagtagatg gaagacgtac 13920

gcgcaggagc acagggacgt gccaggcccg cgcccgccca cccgtcgtca aaggcacgac 13980

cgtcagcggg gtctggtgtg ggaggacgat gactcggcag acgacagcag cgtcctggat 14040

ttgggaggga gtggcaaccc gtttgcgcac cttcgcccca ggctggggag aatgttttaa 14100

aaaaaaaaaa gcatgatgca aaataaaaaa ctcaccaagg ccatggcacc gagcgttggt 14160 tttcttgtat tccccttagt atgcggcgcg cggcgatgta tgaggaaggt cctcctccct 14220

cctacgagag tgtggtgagc gcggcgccag tggcggcggc gctgggttct cccttcgatg 14280

ctcccctgga cccgccgttt gtgcctccgc ggtacctgcg gcctaccggg gggagaaaca 14340 gcatccgtta ctctgagttg gcacccctat tcgacaccac ccgtgtgtac ctggtggaca 14400

acaagtcaac ggatgtggca tccctgaact accagaacga ccacagcaac tttctgacca 14460 cggtcattca aaacaatgac tacagcccgg gggaggcaag cacacagacc atcaatcttg 14520 acgaccggtc gcactggggc ggcgacctga aaaccatcct gcataccaac atgccaaatg 14580

tgaacgagtt catgtttacc aataagttta aggcgcgggt gatggtgtcg cgcttgccta 14640 ctaaggacaa tcaggtggag ctgaaatacg agtgggtgga gttcacgctg cccgagggca 14700 actactccga gaccatgacc atagacctta tgaacaacgc gatcgtggag cactacttga 14760

aagtgggcag acagaacggg gttctggaaa gcgacatcgg ggtaaagttt gacacccgca 14820 acttcagact ggggtttgac cccgtcactg gtcttgtcat gcctggggta tatacaaacg 14880

aagccttcca tccagacatc attttgctgc caggatgcgg ggtggacttc acccacagcc 14940 gcctgagcaa cttgttgggc atccgcaagc ggcaaccctt ccaggagggc tttaggatca 15000 cctacgatga tctggagggt ggtaacattc ccgcactgtt ggatgtggac gcctaccagg 15060

cgagcttgaa agatgacacc gaacagggcg ggggtggcgc aggcggcagc aacagcagtg 15120 Page 117

Sequence_Listing.txt gcagcggcgc ggaagagaac tccaacgcgg cagccgcggc aatgcagccg gtggaggaca 15180

tgaacgatca tgccattcgc ggcgacacct ttgccacacg ggctgaggag aagcgcgctg 15240 aggccgaagc agcggccgaa gctgccgccc ccgctgcgca acccgaggtc gagaagcctc 15300

agaagaaacc ggtgatcaaa cccctgacag aggacagcaa gaaacgcagt tacaacctaa 15360 taagcaatga cagcaccttc acccagtacc gcagctggta ccttgcatac aactacggcg 15420 accctcagac cggaatccgc tcatggaccc tgctttgcac tcctgacgta acctgcggct 15480

cggagcaggt ctactggtcg ttgccagaca tgatgcaaga ccccgtgacc ttccgctcca 15540 cgcgccagat cagcaacttt ccggtggtgg gcgccgagct gttgcccgtg cactccaaga 15600 gcttctacaa cgaccaggcc gtctactccc aactcatccg ccagtttacc tctctgaccc 15660

acgtgttcaa tcgctttccc gagaaccaga ttttggcgcg cccgccagcc cccaccatca 15720 ccaccgtcag tgaaaacgtt cctgctctca cagatcacgg gacgctaccg ctgcgcaaca 15780 gcatcggagg agtccagcga gtgaccatta ctgacgccag acgccgcacc tgcccctacg 15840

tttacaaggc cctgggcata gtctcgccgc gcgtcctatc gagccgcact ttttgagcaa 15900 gcatgtccat ccttatatcg cccagcaata acacaggctg gggcctgcgc ttcccaagca 15960

agatgtttgg cggggccaag aagcgctccg accaacaccc agtgcgcgtg cgcgggcact 16020

accgcgcgcc ctggggcgcg cacaaacgcg gccgcactgg gcgcaccacc gtcgatgacg 16080

ccatcgacgc ggtggtggag gaggcgcgca actacacgcc cacgccgcca ccagtgtcca 16140

cagtggacgc ggccattcag accgtggtgc gcggagcccg gcgctatgct aaaatgaaga 16200 gacggcggag gcgcgtagca cgtcgccacc gccgccgacc cggcactgcc gcccaacgcg 16260

cggcggcggc cctgcttaac cgcgcacgtc gcaccggccg acgggcggcc atgcgggccg 16320

ctcgaaggct ggccgcgggt attgtcactg tgccccccag gtccaggcga cgagcggccg 16380 ccgcagcagc cgcggccatt agtgctatga ctcagggtcg caggggcaac gtgtattggg 16440

tgcgcgactc ggttagcggc ctgcgcgtgc ccgtgcgcac ccgccccccg cgcaactaga 16500 ttgcaagaaa aaactactta gactcgtact gttgtatgta tccagcggcg gcggcgcgca 16560 acgaagctat gtccaagcgc aaaatcaaag aagagatgct ccaggtcatc gcgccggaga 16620

tctatggccc cccgaagaag gaagagcagg attacaagcc ccgaaagcta aagcgggtca 16680 aaaagaaaaa gaaagatgat gatgatgaac ttgacgacga ggtggaactg ctgcacgcta 16740 ccgcgcccag gcgacgggta cagtggaaag gtcgacgcgt aaaacgtgtt ttgcgacccg 16800

gcaccaccgt agtctttacg cccggtgagc gctccacccg cacctacaag cgcgtgtatg 16860 atgaggtgta cggcgacgag gacctgcttg agcaggccaa cgagcgcctc ggggagtttg 16920

cctacggaaa gcggcataag gacatgctgg cgttgccgct ggacgagggc aacccaacac 16980 ctagcctaaa gcccgtaaca ctgcagcagg tgctgcccgc gcttgcaccg tccgaagaaa 17040 agcgcggcct aaagcgcgag tctggtgact tggcacccac cgtgcagctg atggtaccca 17100

agcgccagcg actggaagat gtcttggaaa aaatgaccgt ggaacctggg ctggagcccg 17160 Page 118

Sequence_Listing.txt aggtccgcgt gcggccaatc aagcaggtgg cgccgggact gggcgtgcag accgtggacg 17220

ttcagatacc cactaccagt agcaccagta ttgccaccgc cacagagggc atggagacac 17280 aaacgtcccc ggttgcctca gcggtggcgg atgccgcggt gcaggcggtc gctgcggccg 17340

cgtccaagac ctctacggag gtgcaaacgg acccgtggat gtttcgcgtt tcagcccccc 17400 ggcgcccgcg cggttcgagg aagtacggcg ccgccagcgc gctactgccc gaatatgccc 17460 tacatccttc cattgcgcct acccccggct atcgtggcta cacctaccgc cccagaagac 17520

gagcaactac ccgacgccga accaccactg gaacccgccg ccgccgtcgc cgtcgccagc 17580 ccgtgctggc cccgatttcc gtgcgcaggg tggctcgcga aggaggcagg accctggtgc 17640 tgccaacagc gcgctaccac cccagcatcg tttaaaagcc ggtctttgtg gttcttgcag 17700

atatggccct cacctgccgc ctccgtttcc cggtgccggg attccgagga agaatgcacc 17760 gtaggagggg catggccggc cacggcctga cgggcggcat gcgtcgtgcg caccaccggc 17820 ggcggcgcgc gtcgcaccgt cgcatgcgcg gcggtatcct gcccctcctt attccactga 17880

tcgccgcggc gattggcgcc gtgcccggaa ttgcatccgt ggccttgcag gcgcagagac 17940 actgattaaa aacaagttgc atgtggaaaa atcaaaataa aaagtctgga ctctcacgct 18000

cgcttggtcc tgtaactatt ttgtagaatg gaagacatca actttgcgtc tctggccccg 18060

cgacacggct cgcgcccgtt catgggaaac tggcaagata tcggcaccag caatatgagc 18120

ggtggcgcct tcagctgggg ctcgctgtgg agcggcatta aaaatttcgg ttccaccgtt 18180

aagaactatg gcagcaaggc ctggaacagc agcacaggcc agatgctgag ggataagttg 18240 aaagagcaaa atttccaaca aaaggtggta gatggcctgg cctctggcat tagcggggtg 18300

gtggacctgg ccaaccaggc agtgcaaaat aagattaaca gtaagcttga tccccgccct 18360

cccgtagagg agcctccacc ggccgtggag acagtgtctc cagaggggcg tggcgaaaag 18420 cgtccgcgcc ccgacaggga agaaactctg gtgacgcaaa tagacgagcc tccctcgtac 18480

gaggaggcac taaagcaagg cctgcccacc acccgtccca tcgcgcccat ggctaccgga 18540 gtgctgggcc agcacacacc cgtaacgctg gacctgcctc cccccgccga cacccagcag 18600 aaacctgtgc tgccaggccc gaccgccgtt gttgtaaccc gtcctagccg cgcgtccctg 18660

cgccgcgccg ccagcggtcc gcgatcgttg cggcccgtag ccagtggcaa ctggcaaagc 18720 acactgaaca gcatcgtggg tctgggggtg caatccctga agcgccgacg atgcttctga 18780 atagctaacg tgtcgtatgt gtgtcatgta tgcgtccatg tcgccgccag aggagctgct 18840

gagccgccgc gcgcccgctt tccaagatgg ctaccccttc gatgatgccg cagtggtctt 18900 acatgcacat ctcgggccag gacgcctcgg agtacctgag ccccgggctg gtgcagtttg 18960

cccgcgccac cgagacgtac ttcagcctga ataacaagtt tagaaacccc acggtggcgc 19020 ctacgcacga cgtgaccaca gaccggtccc agcgtttgac gctgcggttc atccctgtgg 19080 accgtgagga tactgcgtac tcgtacaagg cgcggttcac cctagctgtg ggtgataacc 19140

gtgtgctgga catggcttcc acgtactttg acatccgcgg cgtgctggac aggggcccta 19200 Page 119

Sequence_Listing.txt cttttaagcc ctactctggc actgcctaca acgccctggc tcccaagggt gccccaaatc 19260

cttgcgaatg ggatgaagct gctactgctc ttgaaataaa cctagaagaa gaggacgatg 19320 acaacgaaga cgaagtagac gagcaagctg agcagcaaaa aactcacgta tttgggcagg 19380

cgccttattc tggtataaat attacaaagg agggtattca aataggtgtc gaaggtcaaa 19440 cacctaaata tgccgataaa acatttcaac ctgaacctca aataggagaa tctcagtggt 19500 acgaaactga aattaatcat gcagctggga gagtccttaa aaagactacc ccaatgaaac 19560

catgttacgg ttcatatgca aaacccacaa atgaaaatgg agggcaaggc attcttgtaa 19620 agcaacaaaa tggaaagcta gaaagtcaag tggaaatgca atttttctca actactgagg 19680 cgaccgcagg caatggtgat aacttgactc ctaaagtggt attgtacagt gaagatgtag 19740

atatagaaac cccagacact catatttctt acatgcccac tattaaggaa ggtaactcac 19800 gagaactaat gggccaacaa tctatgccca acaggcctaa ttacattgct tttagggaca 19860 attttattgg tctaatgtat tacaacagca cgggtaatat gggtgttctg gcgggccaag 19920

catcgcagtt gaatgctgtt gtagatttgc aagacagaaa cacagagctt tcataccagc 19980 ttttgcttga ttccattggt gatagaacca ggtacttttc tatgtggaat caggctgttg 20040

acagctatga tccagatgtt agaattattg aaaatcatgg aactgaagat gaacttccaa 20100

attactgctt tccactggga ggtgtgatta atacagagac tcttaccaag gtaaaaccta 20160

aaacaggtca ggaaaatgga tgggaaaaag atgctacaga attttcagat aaaaatgaaa 20220

taagagttgg aaataatttt gccatggaaa tcaatctaaa tgccaacctg tggagaaatt 20280 tcctgtactc caacatagcg ctgtatttgc ccgacaagct aaagtacagt ccttccaacg 20340

taaaaatttc tgataaccca aacacctacg actacatgaa caagcgagtg gtggctcccg 20400

ggttagtgga ctgctacatt aaccttggag cacgctggtc ccttgactat atggacaacg 20460 tcaacccatt taaccaccac cgcaatgctg gcctgcgcta ccgctcaatg ttgctgggca 20520

atggtcgcta tgtgcccttc cacatccagg tgcctcagaa gttctttgcc attaaaaacc 20580 tccttctcct gccgggctca tacacctacg agtggaactt caggaaggat gttaacatgg 20640 ttctgcagag ctccctagga aatgacctaa gggttgacgg agccagcatt aagtttgata 20700

gcatttgcct ttacgccacc ttcttcccca tggcccacaa caccgcctcc acgcttgagg 20760 ccatgcttag aaacgacacc aacgaccagt cctttaacga ctatctctcc gccgccaaca 20820 tgctctaccc tatacccgcc aacgctacca acgtgcccat atccatcccc tcccgcaact 20880

gggcggcttt ccgcggctgg gccttcacgc gccttaagac taaggaaacc ccatcactgg 20940 gctcgggcta cgacccttat tacacctact ctggctctat accctaccta gatggaacct 21000

tttacctcaa ccacaccttt aagaaggtgg ccattacctt tgactcttct gtcagctggc 21060 ctggcaatga ccgcctgctt acccccaacg agtttgaaat taagcgctca gttgacgggg 21120 agggttacaa cgttgcccag tgtaacatga ccaaagactg gttcctggta caaatgctag 21180

ctaactacaa cattggctac cagggcttct atatcccaga gagctacaag gaccgcatgt 21240 Page 120

Sequence_Listing.txt actccttctt tagaaacttc cagcccatga gccgtcaggt ggtggatgat actaaataca 21300

aggactacca acaggtgggc atcctacacc aacacaacaa ctctggattt gttggctacc 21360 ttgcccccac catgcgcgaa ggacaggcct accctgctaa cttcccctat ccgcttatag 21420

gcaagaccgc agttgacagc attacccaga aaaagtttct ttgcgatcgc accctttggc 21480 gcatcccatt ctccagtaac tttatgtcca tgggcgcact cacagacctg ggccaaaacc 21540 ttctctacgc caactccgcc cacgcgctag acatgacttt tgaggtggat cccatggacg 21600

agcccaccct tctttatgtt ttgtttgaag tctttgacgt ggtccgtgtg caccggccgc 21660 accgcggcgt catcgaaacc gtgtacctgc gcacgccctt ctcggccggc aacgccacaa 21720 cataaagaag caagcaacat caacaacagc tgccgccatg ggctccagtg agcaggaact 21780

gaaagccatt gtcaaagatc ttggttgtgg gccatatttt ttgggcacct atgacaagcg 21840 ctttccaggc tttgtttctc cacacaagct cgcctgcgcc atagtcaata cggccggtcg 21900 cgagactggg ggcgtacact ggatggcctt tgcctggaac ccgcactcaa aaacatgcta 21960

cctctttgag ccctttggct tttctgacca gcgactcaag caggtttacc agtttgagta 22020 cgagtcactc ctgcgccgta gcgccattgc ttcttccccc gaccgctgta taacgctgga 22080

aaagtccacc caaagcgtac aggggcccaa ctcggccgcc tgtggactat tctgctgcat 22140

gtttctccac gcctttgcca actggcccca aactcccatg gatcacaacc ccaccatgaa 22200

ccttattacc ggggtaccca actccatgct caacagtccc caggtacagc ccaccctgcg 22260

tcgcaaccag gaacagctct acagcttcct ggagcgccac tcgccctact tccgcagcca 22320 cagtgcgcag attaggagcg ccacttcttt ttgtcacttg aaaaacatgt aaaaataatg 22380

tactagagac actttcaata aaggcaaatg cttttatttg tacactctcg ggtgattatt 22440

tacccccacc cttgccgtct gcgccgttta aaaatcaaag gggttctgcc gcgcatcgct 22500 atgcgccact ggcagggaca cgttgcgata ctggtgttta gtgctccact taaactcagg 22560

cacaaccatc cgcggcagct cggtgaagtt ttcactccac aggctgcgca ccatcaccaa 22620 cgcgtttagc aggtcgggcg ccgatatctt gaagtcgcag ttggggcctc cgccctgcgc 22680 gcgcgagttg cgatacacag ggttgcagca ctggaacact atcagcgccg ggtggtgcac 22740

gctggccagc acgctcttgt cggagatcag atccgcgtcc aggtcctccg cgttgctcag 22800 ggcgaacgga gtcaactttg gtagctgcct tcccaaaaag ggcgcgtgcc caggctttga 22860 gttgcactcg caccgtagtg gcatcaaaag gtgaccgtgc ccggtctggg cgttaggata 22920

cagcgcctgc ataaaagcct tgatctgctt aaaagccacc tgagcctttg cgccttcaga 22980 gaagaacatg ccgcaagact tgccggaaaa ctgattggcc ggacaggccg cgtcgtgcac 23040

gcagcacctt gcgtcggtgt tggagatctg caccacattt cggccccacc ggttcttcac 23100 gatcttggcc ttgctagact gctccttcag cgcgcgctgc ccgttttcgc tcgtcacatc 23160 catttcaatc acgtgctcct tatttatcat aatgcttccg tgtagacact taagctcgcc 23220

ttcgatctca gcgcagcggt gcagccacaa cgcgcagccc gtgggctcgt gatgcttgta 23280 Page 121

Sequence_Listing.txt ggtcacctct gcaaacgact gcaggtacgc ctgcaggaat cgccccatca tcgtcacaaa 23340

ggtcttgttg ctggtgaagg tcagctgcaa cccgcggtgc tcctcgttca gccaggtctt 23400 gcatacggcc gccagagctt ccacttggtc aggcagtagt ttgaagttcg cctttagatc 23460

gttatccacg tggtacttgt ccatcagcgc gcgcgcagcc tccatgccct tctcccacgc 23520 agacacgatc ggcacactca gcgggttcat caccgtaatt tcactttccg cttcgctggg 23580 ctcttcctct tcctcttgcg tccgcatacc acgcgccact gggtcgtctt cattcagccg 23640

ccgcactgtg cgcttacctc ctttgccatg cttgattagc accggtgggt tgctgaaacc 23700 caccatttgt agcgccacat cttctctttc ttcctcgctg tccacgatta cctctggtga 23760 tggcgggcgc tcgggcttgg gagaagggcg cttctttttc ttcttgggcg caatggccaa 23820

atccgccgcc gaggtcgatg gccgcgggct gggtgtgcgc ggcaccagcg cgtcttgtga 23880 tgagtcttcc tcgtcctcgg actcgatacg ccgcctcatc cgcttttttg ggggcgcccg 23940 gggaggcggc ggcgacgggg acggggacga cacgtcctcc atggttgggg gacgtcgcgc 24000

cgcaccgcgt ccgcgctcgg gggtggtttc gcgctgctcc tcttcccgac tggccatttc 24060 cttctcctat aggcagaaaa agatcatgga gtcagtcgag aagaaggaca gcctaaccgc 24120

cccctctgag ttcgccacca ccgcctccac cgatgccgcc aacgcgccta ccaccttccc 24180

cgtcgaggca cccccgcttg aggaggagga agtgattatc gagcaggacc caggttttgt 24240

aagcgaagac gacgaggacc gctcagtacc aacagaggat aaaaagcaag accaggacaa 24300

cgcagaggca aacgaggaac aagtcgggcg gggggacgaa aggcatggcg actacctaga 24360 tgtgggagac gacgtgctgt tgaagcatct gcagcgccag tgcgccatta tctgcgacgc 24420

gttgcaagag cgcagcgatg tgcccctcgc catagcggat gtcagccttg cctacgaacg 24480

ccacctattc tcaccgcgcg taccccccaa acgccaagaa aacggcacat gcgagcccaa 24540 cccgcgcctc aacttctacc ccgtatttgc cgtgccagag gtgcttgcca cctatcacat 24600

ctttttccaa aactgcaaga tacccctatc ctgccgtgcc aaccgcagcc gagcggacaa 24660 gcagctggcc ttgcggcagg gcgctgtcat acctgatatc gcctcgctca acgaagtgcc 24720 aaaaatcttt gagggtcttg gacgcgacga gaagcgcgcg gcaaacgctc tgcaacagga 24780

aaacagcgaa aatgaaagtc actctggagt gttggtggaa ctcgagggtg acaacgcgcg 24840 cctagccgta ctaaaacgca gcatcgaggt cacccacttt gcctacccgg cacttaacct 24900 accccccaag gtcatgagca cagtcatgag tgagctgatc gtgcgccgtg cgcagcccct 24960

ggagagggat gcaaatttgc aagaacaaac agaggagggc ctacccgcag ttggcgacga 25020 gcagctagcg cgctggcttc aaacgcgcga gcctgccgac ttggaggagc gacgcaaact 25080

aatgatggcc gcagtgctcg ttaccgtgga gcttgagtgc atgcagcggt tctttgctga 25140 cccggagatg cagcgcaagc tagaggaaac attgcactac acctttcgac agggctacgt 25200 acgccaggcc tgcaagatct ccaacgtgga gctctgcaac ctggtctcct accttggaat 25260

tttgcacgaa aaccgccttg ggcaaaacgt gcttcattcc acgctcaagg gcgaggcgcg 25320 Page 122

Sequence_Listing.txt ccgcgactac gtccgcgact gcgtttactt atttctatgc tacacctggc agacggccat 25380

gggcgtttgg cagcagtgct tggaggagtg caacctcaag gagctgcaga aactgctaaa 25440 gcaaaacttg aaggacctat ggacggcctt caacgagcgc tccgtggccg cgcacctggc 25500

ggacatcatt ttccccgaac gcctgcttaa aaccctgcaa cagggtctgc cagacttcac 25560 cagtcaaagc atgttgcaga actttaggaa ctttatccta gagcgctcag gaatcttgcc 25620 cgccacctgc tgtgcacttc ctagcgactt tgtgcccatt aagtaccgcg aatgccctcc 25680

gccgctttgg ggccactgct accttctgca gctagccaac taccttgcct accactctga 25740 cataatggaa gacgtgagcg gtgacggtct actggagtgt cactgtcgct gcaacctatg 25800 caccccgcac cgctccctgg tttgcaattc gcagctgctt aacgaaagtc aaattatcgg 25860

tacctttgag ctgcagggtc cctcgcctga cgaaaagtcc gcggctccgg ggttgaaact 25920 cactccgggg ctgtggacgt cggcttacct tcgcaaattt gtacctgagg actaccacgc 25980 ccacgagatt aggttctacg aagaccaatc ccgcccgcca aatgcggagc ttaccgcctg 26040

cgtcattacc cagggccaca ttcttggcca attgcaagcc atcaacaaag cccgccaaga 26100 gtttctgcta cgaaagggac ggggggttta cttggacccc cagtccggcg aggagctcaa 26160

cccaatcccc ccgccgccgc agccctatca gcagcagccg cgggcccttg cttcccagga 26220

tggcacccaa aaagaagctg cagctgccgc cgccacccac ggacgaggag gaatactggg 26280

acagtcaggc agaggaggtt ttggacgagg aggaggagga catgatggaa gactgggaga 26340

gcctagacga ggaagcttcc gaggtcgaag aggtgtcaga cgaaacaccg tcaccctcgg 26400 tcgcattccc ctcgccggcg ccccagaaat cggcaaccgg ttccagcatg gctacaacct 26460

ccgctcctca ggcgccgccg gcactgcccg ttcgccgacc caaccgtaga tgggacacca 26520

ctggaaccag ggccggtaag tccaagcagc cgccgccgtt agcccaagag caacaacagc 26580 gccaaggcta ccgctcatgg cgcgggcaca agaacgccat agttgcttgc ttgcaagact 26640

gtgggggcaa catctccttc gcccgccgct ttcttctcta ccatcacggc gtggccttcc 26700 cccgtaacat cctgcattac taccgtcatc tctacagccc atactgcacc ggcggcagcg 26760 gcagcggcag caacagcagc ggccacacag aagcaaaggc gaccggatag caagactctg 26820

acaaagccca agaaatccac agcggcggca gcagcaggag gaggagcgct gcgtctggcg 26880 cccaacgaac ccgtatcgac ccgcgagctt agaaacagga tttttcccac tctgtatgct 26940 atatttcaac agagcagggg ccaagaacaa gagctgaaaa taaaaaacag gtctctgcga 27000

tccctcaccc gcagctgcct gtatcacaaa agcgaagatc agcttcggcg cacgctggaa 27060 gacgcggagg ctctcttcag taaatactgc gcgctgactc ttaaggacta gtttcgcgcc 27120

ctttctcaaa tttaagcgcg aaaactacgt catctccagc ggccacaccc ggcgccagca 27180 cctgtcgtca gcgccatttc aactttgtat acaaaagttg tgatgagcaa ggaaattccc 27240 acgccctaca tgtggagtta ccagccacaa atgggacttg cggctggagc tgcccaagac 27300

tactcaaccc gaataaacta catgagcgcg ggaccccaca tgatatcccg ggtcaacgga 27360 Page 123

Sequence_Listing.txt atacgcgccc accgaaaccg aattctcctg gaacaggcgg ctattaccac cacacctcgt 27420

aataacctta atccccgtag ttggcccgct gccctggtgt accaggaaag tcccgctccc 27480 accactgtgg tacttcccag agacgcccag gccgaagttc agatgactaa ctcaggggcg 27540

cagcttgcgg gcggctttcg tcacagggtg cggtcgcccg ggcagggtat aactcacctg 27600 acaatcagag ggcgaggtat tcagctcaac gacgagtcgg tgagctcctc gcttggtctc 27660 cgtccggacg ggacatttca gatcggcggc gccggccgct cttcattcac gcctcgtcag 27720

gcaatcctaa ctctgcagac ctcgtcctct gagccgcgct ctggaggcat tggaactctg 27780 caatttattg aggagtttgt gccatcggtc tactttaacc ccttctcggg acctcccggc 27840 cactatccgg atcaatttat tcctaacttt gacgcggtaa aggactcggc ggacggctac 27900

gactgaatgt taagtggaga ggcagagcaa ctgcgcctga aacacctggt ccactgtcgc 27960 cgccacaagt gctttgcccg cgactccggt gagttttgct actttgaatt gcccgaggat 28020 catatcgagg gcccggcgca cggcgtccgg cttaccgccc agggagagct tgcccgtagc 28080

ctgattcggg agtttaccca gcgccccctg ctagttgagc gggacagggg accctgtgtt 28140 ctcactgtga tttgcaactg tcctaaccct ggattacatc aagatctttg ttgccatctc 28200

tgtgctgagt ataataaata cagaaattaa aatatactgg ggctcctatc gccatcctgt 28260

aaacgccacc gtcttcaccc gcccaagcaa accaaggcga accttacctg gtacttttaa 28320

catctctccc tctgtgattt acaacagttt caacccagac ggagtgagtc tacgagagaa 28380

cctctccgag ctcagctact ccatcagaaa aaacaccacc ctccttacct gccgggaacg 28440 tacgagtgcg tcaccggccg ctgcaccaca cctaccgcct gaccgtaaac cagacttttt 28500

ccggacagac ctcaataact ctgtttacca gaacaggagg tgagcttaga aaacccttag 28560

ggtattaggc caaaggcgca gctactgtgg ggtttatgaa caattcaagc aactctacgg 28620 gctattctaa ttcaggtttc tctagaatcg gggttggggt tattctctgt cttgtgattc 28680

tctttattct tatactaacg cttctctgcc taaggctcgc cgcctgctgt gtgcacattt 28740 gcatttattg tcagcttttt aaacgctggg gtcgccaccc aagatgatta ggtacataat 28800 cctaggttta ctcacccttg cgtcagccca cggtaccacc caaaaggtgg attttaagga 28860

gccagcctgt aatgttacat tcgcagctga agctaatgag tgcaccactc ttataaaatg 28920 caccacagaa catgaaaagc tgcttattcg ccacaaaaac aaaattggca agtatgctgt 28980 ttatgctatt tggcagccag gtgacactac agagtataat gttacagttt tccagggtaa 29040

aagtcataaa acttttatgt atacttttcc attttatgaa atgtgcgaca ttaccatgta 29100 catgagcaaa cagtataagt tgtggccccc acaaaattgt gtggaaaaca ctggcacttt 29160

ctgctgcact gctatgctaa ttacagtgct cgctttggtc tgtaccctac tctatattaa 29220 atacaaaagc agacgcagct ttattgagga aaagaaaatg ccttaattta ctaagttaca 29280 aagctaatgt caccactaac tgctttactc gctgcttgca aaacaaattc aaaaagttag 29340

cattataatt agaataggat ttaaaccccc cggtcatttc ctgctcaata ccattcccct 29400 Page 124

Sequence_Listing.txt gaacaattga ctctatgtgg gatatgctcc agcgctacaa ccttgaagtc aggcttcctg 29460

gatgtcagca tctgactttg gccagcacct gtcccgcgga tttgttccag tccaactaca 29520 gcgacccacc ctaacagaga tggtgagcaa aggcgaagag ctgttcaccg gcgtggtgcc 29580

catcctggtg gagctggacg gcgacgtgaa cggccacaag ttcagcgtga gcggcgaggg 29640 cgagggcgac gccacctacg gcaagctgac cctgaagctg ctgtgcacca ccggcaagct 29700 gcccgtgccc tggcccaccc tggtgaccac cctgggctac ggcgtgcagt gcttcgcccg 29760

gtaccccgac cacatgaagc agcacgactt cttcaagagc gccatgcccg agggctacgt 29820 gcaggagcgg accatcttct tcaaggacga cggcaactac aagacccggg ccgaggtgaa 29880 gttcgagggc gacaccctgg tgaaccggat cgagctgaag ggcatcgact tcaaggagga 29940

cggcaacatc ctgggccaca agctggagta caactacaac agccacaacg tgtacatcac 30000 cgccgacaag cagaagaacg gcatcaaggc caacttcaag atccggcaca acatcgagga 30060 cggcggcgtg cagctggccg accactacca gcagaacacc cccatcggcg acggccccgt 30120

gctgctgccc gacaaccact acctgagcta ccagagcgcc ctgttcaagg accccaacga 30180 gaagcgggac cacatggtgc tgctggagtt cctgaccgcc gccggcatca ccgagggcat 30240

gaacgagctc tataagggaa gcggagctac taacttcagc ctgctgaagc aggctggtga 30300

cgtcgaggag aatcctggcc caatggtgat gaccaacaca accaacgcgg ccgccgctac 30360

cggacttaca tctaccacaa atacacccca agtttctgcc tttgtcaata actgggataa 30420

cttgggcatg tggtggttct ccatagcgct tatgtttgta tgccttatta ttatgtggct 30480 catctgctgc ctaaagcgca aacgcgcccg accacccatc tatagtccca tcattgtgct 30540

acacccaaac aatgatggaa tccatagatt ggacggactg aaacacatgt tcttttctct 30600

tacagtatga ttaaatgaga catgattcct cgagttttta tattactgac ccttgttgcg 30660 cttttttgtg cgtgctccac attggctgcg gtttctcaca tcgaagtaga ctgcattcca 30720

gccttcacag tctatttgct ttacggattt gtcaccctca cgctcatctg cagcctcatc 30780 actgtggtca tcgcctttat ccagtgcatt gactgggtct gtgtgcgctt tgcatatctc 30840 agacaccatc cccagtacag ggacaggact atagctgagc ttcttagaat tctttaatta 30900

tgaaatttac tgtgactttt ctgctgatta tttgcaccct atctgcgttt tgttccccga 30960 cctccaagcc tcaaagacat atatcatgca gattcactcg tatatggaat attccaagtt 31020 gctacaatga aaaaagcgat ctttccgaag cctggttata tgcaatcatc tctgttatgg 31080

tgttctgcag taccatctta gccctagcta tatatcccta ccttgacatt ggctggaacg 31140 caatagatgc catgaaccac ccaactttcc ccgcgcccgc tatgcttcca ctgcaacaag 31200

ttgttgccgg cggctttgtc ccagccaatc agcctcgccc accttctccc acccccactg 31260 aaatcagcta ctttaatcta acaggaggag atgactgaca ccctagatct agaaatggac 31320 ggaattatta cagagcagcg cctgctagaa agacgcaggg cagcggccga gcaacagcgc 31380

atgaatcaag agctccaaga catggttaac ttgcaccagt gcaaaagggg tatcttttgt 31440 Page 125

Sequence_Listing.txt ctggtaaagc aggccaaagt cacctacgac agtaatacca ccggacaccg ccttagctac 31500

aagttgccaa ccaagcgtca gaaattggtg gtcatggtgg gagaaaagcc cattaccata 31560 actcagcact cggtagaaac cgaaggctgc attcactcac cttgtcaagg acctgaggat 31620

ctctgcaccc ttattaagac cctgtgcggt ctcaaagatc ttattccctt taactaataa 31680 aaaaaaataa taaagcatca cttacttaaa atcagttagc aaatttctgt ccagtttatt 31740 cagcagcacc tccttgccct cctcccagct ctggtattgc agcttcctcc tggctgcaaa 31800

ctttctccac aatctaaatg gaatgtcagt ttcctcctgt tcctgtccat ccgcacccac 31860 tatcttcatg ttgttgcaga tgaagcgcgc aagaccgtct gaagatacct tcaaccccgt 31920 gtatccatat gacacggaaa ccggtcctcc aactgtgcct tttcttactc ctccctttgt 31980

atcccccaat gggtttcaag agagtccccc tggggtactc tctttgcgcc tatccgaacc 32040 tctagttacc tccaatggca tgcttgcgct caaaatgggc aacggcctct ctctggacga 32100 ggccggcaac cttacctccc aaaatgtaac cactgtgagc ccacctctca aaaaaaccaa 32160

gtcaaacata aacctggaaa tatctgcacc cctcacagtt acctcagaag ccctaactgt 32220 ggctgccgcc gcacctctaa tggtcgcggg caacacactc accatgcaat cacaggcccc 32280

gctaaccgtg cacgactcca aacttagcat tgccacccaa ggacccctca cagtgtcaga 32340

aggaaagcta gccctgcaaa catcaggccc cctcaccacc accgatagca gtacccttac 32400

tatcactgcc tcaccccctc taactactgc cactggtagc ttgggcattg acttgaaaga 32460

gcccatttat acacaaaatg gaaaactagg actaaagtac ggggctcctt tgcatgtaac 32520 agacgaccta aacactttga ccgtagcaac tggtccaggt gtgactatta ataatacttc 32580

cttgcaaact aaagttactg gagccttggg ttttgattca caaggcaata tgcaacttaa 32640

tgtagcagga ggactaagga ttgattctca aaacagacgc cttatacttg atgttagtta 32700 tccgtttgat gctcaaaacc aactaaatct aagactagga cagggccctc tttttataaa 32760

ctcagcccac aacttggata ttaactacaa caaaggcctt tacttgttta cagcttcaaa 32820 caattccaaa aagcttgagg ttaacctaag cactgccaag gggttgatgt ttgacgctac 32880 agccatagcc attaatgcag gagatgggct tgaatttggt tcacctaatg caccaaacac 32940

aaatcccctc aaaacaaaaa ttggccatgg cctagaattt gattcaaaca aggctatggt 33000 tcctaaacta ggaactggcc ttagttttga cagcacaggt gccattacag taggaaacaa 33060 aaataatgat aagctaactt tgtggaccac accagctcca tctcctaact gtagactaaa 33120

tgcagagaaa gatgctaaac tcactttggt cttaacaaaa tgtggcagtc aaatacttgc 33180 tacagtttca gttttggctg ttaaaggcag tttggctcca atatctggaa cagttcaaag 33240

tgctcatctt attataagat ttgacgaaaa tggagtgcta ctaaacaatt ccttcctgga 33300 cccagaatat tggaacttta gaaatggaga tcttactgaa ggcacagcct atacaaacgc 33360 tgttggattt atgcctaacc tatcagctta tccaaaatct cacggtaaaa ctgccaaaag 33420

taacattgtc agtcaagttt acttaaacgg agacaaaact aaacctgtaa cactaaccat 33480 Page 126

Sequence_Listing.txt tacactaaac ggtacacagg aaacaggaga cacaactcca agtgcatact ctatgtcatt 33540

ttcatgggac tggtctggcc acaactacat taatgaaata tttgccacat cctcttacac 33600 tttttcatac attgcccaag aataaagaat cgtttgtgtt atgtttcaac gtgtttattt 33660

ttcaattgca gaaaatttca agtcattttt cattcagtag tatagcccca ccaccacata 33720 gcttatacag atcaccgtac ctcaactttg tataataaag ttgtaatcaa actcacagaa 33780 ccctagtatt caacctgcca cctccctccc aacacacaga gtacacagtc ctttctcccc 33840

ggctggcctt aaaaagcatc atatcatggg taacagacat attcttaggt gttatattcc 33900 acacggtttc ctgtcgagcc aaacgctcat cagtgatatt aataaactcc ccgggcagct 33960 cacttaagtt catgtcgctg tccagctgct gagccacagg ctgctgtcca acttgcggtt 34020

gcttaacggg cggcgaagga gaagtccacg cctacatggg ggtagagtca taatcgtgca 34080 tcaggatagg gcggtggtgc tgcagcagcg cgcgaataaa ctgctgccgc cgccgctccg 34140 tcctgcagga atacaacatg gcagtggtct cctcagcgat gattcgcacc gcccgcagca 34200

taaggcgcct tgtcctccgg gcacagcagc gcaccctgat ctcacttaaa tcagcacagt 34260 aactgcagca cagcaccaca atattgttca aaatcccaca gtgcaaggcg ctgtatccaa 34320

agctcatggc ggggaccaca gaacccacgt ggccatcata ccacaagcgc aggtagatta 34380

agtggcgacc cctcataaac acgctggaca taaacattac ctcttttggc atgttgtaat 34440

tcaccacctc ccggtaccat ataaacctct gattaaacat ggcgccatcc accaccatcc 34500

taaaccagct ggccaaaacc tgcccgccgg ctatacactg cagggaaccg ggactggaac 34560 aatgacagtg gagagcccag gactcgtaac catggatcat catgctcgtc atgatatcaa 34620

tgttggcaca acacaggcac acgtgcatac acttcctcag gattacaagc tcctcccgcg 34680

ttagaaccat atcccaggga acaacccatt cctgaatcag cgtaaatccc acactgcagg 34740 gaagacctcg cacgtaactc acgttgtgca ttgtcaaagt gttacattcg ggcagcagcg 34800

gatgatcctc cagtatggta gcgcgggttt ctgtctcaaa aggaggtaga cgatccctac 34860 tgtacggagt gcgccgagac aaccgagatc gtgttggtcg tagtgtcatg ccaaatggaa 34920 cgccggacgt agtcatattt cctgaagcaa aaccaggtgc gggcgtgaca aacagatctg 34980

cgtctccggt ctcgccgctt agatcgctct gtgtagtagt tgtagtatat ccactctctc 35040 aaagcatcca ggcgccccct ggcttcgggt tctatgtaaa ctccttcatg cgccgctgcc 35100 ctgataacat ccaccaccgc agaataagcc acacccagcc aacctacaca ttcgttctgc 35160

gagtcacaca cgggaggagc gggaagagct ggaagaacca tgtttttttt tttattccaa 35220 aagattatcc aaaacctcaa aatgaagatc tattaagtga acgcgctccc ctccggtggc 35280

gtggtcaaac tctacagcca aagaacagat aatggcattt gtaagatgtt gcacaatggc 35340 ttccaaaagg caaacggccc tcacgtccaa gtggacgtaa aggctaaacc cttcagggtg 35400 aatctcctct ataaacattc cagcaccttc aaccatgccc aaataattct catctcgcca 35460

ccttctcaat atatctctaa gcaaatcccg aatattaagt ccggccattg taaaaatctg 35520 Page 127

Sequence_Listing.txt ctccagagcg ccctccacct tcagcctcaa gcagcgaatc atgattgcaa aaattcaggt 35580

tcctcacaga cctgtataag attcaaaagc ggaacattaa caaaaatacc gcgatcccgt 35640 aggtcccttc gcagggccag ctgaacataa tcgtgcaggt ctgcacggac cagcgcggcc 35700

acttccccgc caggaaccat gacaaaagaa cccacactga ttatgacacg catactcgga 35760 gctatgctaa ccagcgtagc cccgatgtaa gcttgttgca tgggcggcga tataaaatgc 35820 aaggtgctgc tcaaaaaatc aggcaaagcc tcgcgcaaaa aagaaagcac atcgtagtca 35880

tgctcatgca gataaaggca ggtaagctcc ggaaccacca cagaaaaaga caccattttt 35940 ctctcaaaca tgtctgcggg tttctgcata aacacaaaat aaaataacaa aaaaacattt 36000 aaacattaga agcctgtctt acaacaggaa aaacaaccct tataagcata agacggacta 36060

cggccatgcc ggcgtgaccg taaaaaaact ggtcaccgtg attaaaaagc accaccgaca 36120 gctcctcggt catgtccgga gtcataatgt aagactcggt aaacacatca ggttgattca 36180 catcggtcag tgctaaaaag cgaccgaaat agcccggggg aatacatacc cgcaggcgta 36240

gagacaacat tacagccccc ataggaggta taacaaaatt aataggagag aaaaacacat 36300 aaacacctga aaaaccctcc tgcctaggca aaatagcacc ctcccgctcc agaacaacat 36360

acagcgcttc cacagcggca gccataacag tcagccttac cagtaaaaaa gaaaacctat 36420

taaaaaaaca ccactcgaca cggcaccagc tcaatcagtc acagtgtaaa aaagggccaa 36480

gtgcagagcg agtatatata ggactaaaaa atgacgtaac ggttaaagtc cacaaaaaac 36540

acccagaaaa ccgcacgcga acctacgccc agaaacgaaa gccaaaaaac ccacaacttc 36600 ctcaaatcgt cacttccgtt ttcccacgtt acgtcacttc ccattttaag aaaactacaa 36660

ttcccaacac atacaagtta ctccgcccta aaacctacgt cacccgcccc gttcccacgc 36720

cccgcgccac gtcacaaact ccaccccctc attatcatat tggcttcaat ccaaaataag 36780 gtatattatt gatgatg 36797

<210> 8 <211> 36791 <212> DNA <213> Artificial Sequence

<220> <223> Synthetic adenovirus genome ADP-P2A-YPet

<400> 8 catcatcaat aatatacctt attttggatt gaagccaata tgataatgag ggggtggagt 60

ttgtgacgtg gcgcggggcg tgggaacggg gcgggtgacg tagtagtgtg gcggaagtgt 120 gatgttgcaa gtgtggcgga acacatgtaa gcgacggatg tggcaaaagt gacgtttttg 180

gtgtgcgccg gtgtacacag gaagtgacaa ttttcgcgcg gttttaggcg gatgttgtag 240 taaatttggg cgtaaccgag taagatttgg ccattttcgc gggaaaactg aataagagga 300 agtgaaatct gaataatttt gtgttactca tagcgcgtaa tatttgtcta gggccgcggg 360

gactttgacc gtttacgtgg agactcgccc aggtgttttt ctcaggtgtt ttccgcgttc 420 Page 128

Sequence_Listing.txt cgggtcaaag ttggcgtttt attattatag tcagctgacg tgtagtgtat ttatacccgg 480

tgagttcctc aagaggccac tcttgagtgc cagcgagtag agttttctcc tccgagccgc 540 tccgacaccg ggactgaaaa tgagacatat tatctgccac ggaggtgtta ttaccgaaga 600

aatggccgcc agtcttttgg accagctgat cgaagaggta ctggctgata atcttccacc 660 tcctagccat tttgaaccac ctacccttca cgaactgtat gatttagacg tgacggcccc 720 cgaagatccc aacgaggagg cggtttcgca gatttttccc gactctgtaa tgttggcggt 780

gcaggaaggg attgacttac tcacttttcc gccggcgccc ggttctccgg agccgcctca 840 cctttcccgg cagcccgagc agccggagca gagagccttg ggtccggttt ctatgccaaa 900 ccttgtaccg gaggtgatcg atcttacctg ccacgaggct ggctttccac ccagtgacga 960

cgaggatgaa gagggtgagg agtttgtgtt agattatgtg gagcaccccg ggcacggttg 1020 caggtcttgt cattatcacc ggaggaatac gggggaccca gatattatgt gttcgctttg 1080 ctatatgagg acctgtggca tgtttgtcta cagtaagtga aaattatggg cagtgggtga 1140

tagagtggtg ggtttggtgt ggtaattttt tttttaattt ttacagtttt gtggtttaaa 1200 gaattttgta ttgtgatttt tttaaaaggt cctgtgtctg aacctgagcc tgagcccgag 1260

ccagaaccgg agcctgcaag acctacccgc cgtcctaaaa tggcgcctgc tatcctgaga 1320

cgcccgacat cacctgtgtc tagagaatgc aatagtagta cggatagctg tgactccggt 1380

ccttctaaca cacctcctga gatacacccg gtggtcccgc tgtgccccat taaaccagtt 1440

gccgtgagag ttggtgggcg tcgccaggct gtggaatgta tcgaggactt gcttaacgag 1500 cctgggcaac ctttggactt gagctgtaaa cgccccaggc cataaggtgt aaacctgtga 1560

ttgcgtgtgt ggttaacgcc tttgtttgct gaatgagttg atgtaagttt aataaagggt 1620

gagataatgt ttaacttgca tggcgtgtta aatggggcgg ggcttaaagg gtatataatg 1680 cgccgtgggc taatcttggt tacatctgac ctcatggagg cttgggagtg tttggaagat 1740

ttttctgctg tgcgtaactt gctggaacag agctctaaca gtacctcttg gttttggagg 1800 tttctgtggg gctcatccca ggcaaagtta gtctgcagaa ttaaggagga ttacaagtgg 1860 gaatttgaag agcttttgaa atcctgtggt gagctgtttg attctttgaa tctgggtcac 1920

caggcgcttt tccaagagaa ggtcatcaag actttggatt tttccacacc ggggcgcgct 1980 gcggctgctg ttgctttttt gagttttata aaggataaat ggagcgaaga aacccatctg 2040 agcggggggt acctgctgga ttttctggcc atgcatctgt ggagagcggt tgtgagacac 2100

aagaatcgcc tgctactgtt gtcttccgtc cgcccggcga taataccgac ggaggagcag 2160 cagcagcagc aggaggaagc caggcggcgg cggcaggagc agagcccatg gaacccgaga 2220

gccggcctgg accctcggga atgaatgttg tacaggtggc tgaactgtat ccagaactga 2280 gacgcatttt gacaattaca gaggatgggc aggggctaaa gggggtaaag agggagcggg 2340 gggcttgtga ggctacagag gaggctagga atctagcttt tagcttaatg accagacacc 2400

gtcctgagtg tattactttt caacagatca aggataattg cgctaatgag cttgatctgc 2460 Page 129

Sequence_Listing.txt tggcgcagaa gtattccata gagcagctga ccacttactg gctgcagcca ggggatgatt 2520

ttgaggaggc tattagggta tatgcaaagg tggcacttag gccagattgc aagtacaaga 2580 tcagcaaact tgtaaatatc aggaattgtt gctacatttc tgggaacggg gccgaggtgg 2640

agatagatac ggaggatagg gtggccttta gatgtagcat gataaatatg tggccggggg 2700 tgcttggcat ggacggggtg gttattatga atgtaaggtt tactggcccc aattttagcg 2760 gtacggtttt cctggccaat accaacctta tcctacacgg tgtaagcttc tatgggttta 2820

acaatacctg tgtggaagcc tggaccgatg taagggttcg gggctgtgcc ttttactgct 2880 gctggaaggg ggtggtgtgt cgccccaaaa gcagggcttc aattaagaaa tgcctctttg 2940 aaaggtgtac cttgggtatc ctgtctgagg gtaactccag ggtgcgccac aatgtggcct 3000

ccgactgtgg ttgcttcatg ctagtgaaaa gcgtggctgt gattaagcat aacatggtat 3060 gtggcaactg cgaggacagg gcctctcaga tgctgacctg ctcggacggc aactgtcacc 3120 tgctgaagac cattcacgta gccagccact ctcgcaaggc ctggccagtg tttgagcata 3180

acatactgac ccgctgttcc ttgcatttgg gtaacaggag gggggtgttc ctaccttacc 3240 aatgcaattt gagtcacact aagatattgc ttgagcccga gagcatgtcc aaggtgaacc 3300

tgaacggggt gtttgacatg accatgaaga tctggaaggt gctgaggtac gatgagaccc 3360

gcaccaggtg cagaccctgc gagtgtggcg gtaaacatat taggaaccag cctgtgatgc 3420

tggatgtgac cgaggagctg aggcccgatc acttggtgct ggcctgcacc cgcgctgagt 3480

ttggctctag cgatgaagat acagattgag gtactgaaat gtgtgggcgt ggcttaaggg 3540 tgggaaagaa tatataaggt gggggtctta tgtagttttg tatctgtttt gcagcagccg 3600

ccgccgccca acttttctat acaaagttgt aatgagcacc aactcgtttg atggaagcat 3660

tgtgagctca tatttgacaa cgcgcatgcc cccatgggcc ggggtgcgtc agaatgtgat 3720 gggctccagc attgatggtc gccccgtcct gcccgcaaac tctactacct tgacctacga 3780

gaccgtgtct ggaacgccgt tggagactgc agcctccgcc gccgcttcag ccgctgcagc 3840 caccgcccgc gggattgtga ctgactttgc tttcctgagc ccgcttgcaa gcagtgcagc 3900 ttcccgttca tccgcccgcg atgacaagtt gacggctctt ttggcacaat tggattcttt 3960

gacccgggaa cttaatgtcg tttctcagca gctgttggat ctgcgccagc aggtttctgc 4020 cctgaaggct tcctcccctc ccaatgcggt ttaaaacata aataaaaaac cagactctgt 4080 ttggatttgg atcaagcata agtgtcttgc tgtctttatt taggggtttt gcgcgcgcgg 4140

taggcccggg accagcggtc tcggtcgttg agggtcctgt gtattttttc caggacgtgg 4200 taaaggtgac tctggatgtt cagatacatg ggcataagcc cgtctctggg gtggaggtag 4260

caccactgca gagcttcatg ctgcggggtg gtgttgtaga tgatccagtc gtagcaggag 4320 cgctgggcgt ggtgcctaaa aatgtctttc agtagcaagc tgattgccag gggcaggccc 4380 ttggtgtaag tgtttacaaa gcggttaagc tgggatgggt gcatacgtgg ggatatgaga 4440

tgcatcttgg actgtatttt taggttggct atgttcccag ccatatccct ccggggattc 4500 Page 130

Sequence_Listing.txt atgttgtgca gaaccaccag cacagtgtat ccggtgcact tgggaaattt gtcatgtagc 4560

ttagaaggaa atgcgtggaa gaacttggag acgcccttgt gacctccaag attttccatg 4620 cattcgtcca taatgatggc aatgggccca cgggcggcgg cctgggcgaa gatatttctg 4680

ggatcactaa cgtcatagtt gtgttccagg atgagatcgt cataggccat ttttacaaag 4740 cgcgggcgga gggtgccaga ctgcggtata atggttccat ccggcccagg ggcgtagtta 4800 ccctcacaga tttgcatttc ccacgctttg agttcagatg gggggatcat gtctacctgc 4860

ggggcgatga agaaaacggt ttccggggta ggggagatca gctgggaaga aagcaggttc 4920 ctgagcagct gcgacttacc gcagccggtg ggcccgtaaa tcacacctat taccgggtgc 4980 aactggtagt taagagagct gcagctgccg tcatccctga gcaggggggc cacttcgtta 5040

agcatgtccc tgactcgcat gttttccctg accaaatccg ccagaaggcg ctcgccgccc 5100 agcgatagca gttcttgcaa ggaagcaaag tttttcaacg gtttgagacc gtccgccgta 5160 ggcatgcttt tgagcgtttg accaagcagt tccaggcggt cccacagctc ggtcacctgc 5220

tctacggcat ctcgatccag catatctcct cgtttcgcgg gttggggcgg ctttcgctgt 5280 acggcagtag tcggtgctcg tccagacggg ccagggtcat gtctttccac gggcgcaggg 5340

tcctcgtcag cgtagtctgg gtcacggtga aggggtgcgc tccgggctgc gcgctggcca 5400

gggtgcgctt gaggctggtc ctgctggtgc tgaagcgctg ccggtcttcg ccctgcgcgt 5460

cggccaggta gcatttgacc atggtgtcat agtccagccc ctccgcggcg tggcccttgg 5520

cgcgcagctt gcccttggag gaggcgccgc acgaggggca gtgcagactt ttgagggcgt 5580 agagcttggg cgcgagaaat accgattccg gggagtaggc atccgcgccg caggccccgc 5640

agacggtctc gcattccacg agccaggtga gctctggccg ttcggggtca aaaaccaggt 5700

ttcccccatg ctttttgatg cgtttcttac ctctggtttc catgagccgg tgtccacgct 5760 cggtgacgaa aaggctgtcc gtgtccccgt atacagactt gagaggcctg tcctcgagcg 5820

gtgttccgcg gtcctcctcg tatagaaact cggaccactc tgagacaaag gctcgcgtcc 5880 aggccagcac gaaggaggct aagtgggagg ggtagcggtc gttgtccact agggggtcca 5940 ctcgctccag ggtgtgaaga cacatgtcgc cctcttcggc atcaaggaag gtgattggtt 6000

tgtaggtgta ggccacgtga ccgggtgttc ctgaaggggg gctataaaag ggggtggggg 6060 cgcgttcgtc ctcactctct tccgcatcgc tgtctgcgag ggccagctgt tggggtgagt 6120 actccctctg aaaagcgggc atgacttctg cgctaagatt gtcagtttcc aaaaacgagg 6180

aggatttgat attcacctgg cccgcggtga tgcctttgag ggtggccgca tccatctggt 6240 cagaaaagac aatctttttg ttgtcaagct tggtggcaaa cgacccgtag agggcgttgg 6300

acagcaactt ggcgatggag cgcagggttt ggtttttgtc gcgatcggcg cgctccttgg 6360 ccgcgatgtt tagctgcacg tattcgcgcg caacgcaccg ccattcggga aagacggtgg 6420 tgcgctcgtc gggcaccagg tgcacgcgcc aaccgcggtt gtgcagggtg acaaggtcaa 6480

cgctggtggc tacctctccg cgtaggcgct cgttggtcca gcagaggcgg ccgcccttgc 6540 Page 131

Sequence_Listing.txt gcgagcagaa tggcggtagg gggtctagct gcgtctcgtc cggggggtct gcgtccacgg 6600

taaagacccc gggcagcagg cgcgcgtcga agtagtctat cttgcatcct tgcaagtcta 6660 gcgcctgctg ccatgcgcgg gcggcaagcg cgcgctcgta tgggttgagt gggggacccc 6720

atggcatggg gtgggtgagc gcggaggcgt acatgccgca aatgtcgtaa acgtagaggg 6780 gctctctgag tattccaaga tatgtagggt agcatcttcc accgcggatg ctggcgcgca 6840 cgtaatcgta tagttcgtgc gagggagcga ggaggtcggg accgaggttg ctacgggcgg 6900

gctgctctgc tcggaagact atctgcctga agatggcatg tgagttggat gatatggttg 6960 gacgctggaa gacgttgaag ctggcgtctg tgagacctac cgcgtcacgc acgaaggagg 7020 cgtaggagtc gcgcagcttg ttgaccagct cggcggtgac ctgcacgtct agggcgcagt 7080

agtccagggt ttccttgatg atgtcatact tatcctgtcc cttttttttc cacagctcgc 7140 ggttgaggac aaactcttcg cggtctttcc agtactcttg gatcggaaac ccgtcggcct 7200 ccgaacggta agagcctagc atgtagaact ggttgacggc ctggtaggcg cagcatccct 7260

tttctacggg tagcgcgtat gcctgcgcgg ccttccggag cgaggtgtgg gtgagcgcaa 7320 aggtgtccct gaccatgact ttgaggtact ggtatttgaa gtcagtgtcg tcgcatccgc 7380

cctgctccca gagcaaaaag tccgtgcgct ttttggaacg cggatttggc agggcgaagg 7440

tgacatcgtt gaagagtatc tttcccgcgc gaggcataaa gttgcgtgtg atgcggaagg 7500

gtcccggcac ctcggaacgg ttgttaatta cctgggcggc gagcacgatc tcgtcaaagc 7560

cgttgatgtt gtggcccaca atgtaaagtt ccaagaagcg cgggatgccc ttgatggaag 7620 gcaatttttt aagttcctcg taggtgagct cttcagggga gctgagcccg tgctctgaaa 7680

gggcccagtc tgcaagatga gggttggaag cgacgaatga gctccacagg tcacgggcca 7740

ttagcatttg caggtggtcg cgaaaggtcc taaactggcg acctatggcc attttttctg 7800 gggtgatgca gtagaaggta agcgggtctt gttcccagcg gtcccatcca aggttcgcgg 7860

ctaggtctcg cgcggcagtc actagaggct catctccgcc gaacttcatg accagcatga 7920 agggcacgag ctgcttccca aaggccccca tccaagtata ggtctctaca tcgtaggtga 7980 caaagagacg ctcggtgcga ggatgcgagc cgatcgggaa gaactggatc tcccgccacc 8040

aattggagga gtggctattg atgtggtgaa agtagaagtc cctgcgacgg gccgaacact 8100 cgtgctggct tttgtaaaaa cgtgcgcagt actggcagcg gtgcacgggc tgtacatcct 8160 gcacgaggtt gacctgacga ccgcgcacaa ggaagcagag tgggaatttg agcccctcgc 8220

ctggcgggtt tggctggtgg tcttctactt cggctgcttg tccttgaccg tctggctgct 8280 cgaggggagt tacggtggat cggaccacca cgccgcgcga gcccaaagtc cagatgtccg 8340

cgcgcggcgg tcggagcttg atgacaacat cgcgcagatg ggagctgtcc atggtctgga 8400 gctcccgcgg cgtcaggtca ggcgggagct cctgcaggtt tacctcgcat agacgggtca 8460 gggcgcgggc tagatccagg tgatacctaa tttccagggg ctggttggtg gcggcgtcga 8520

tggcttgcaa gaggccgcat ccccgcggcg cgactacggt accgcgcggc gggcggtggg 8580 Page 132

Sequence_Listing.txt ccgcgggggt gtccttggat gatgcatcta aaagcggtga cgcgggcgag cccccggagg 8640

tagggggggc tccggacccg ccgggagagg gggcaggggc acgtcggcgc cgcgcgcggg 8700 caggagctgg tgctgcgcgc gtaggttgct ggcgaacgcg acgacgcggc ggttgatctc 8760

ctgaatctgg cgcctctgcg tgaagacgac gggcccggtg agcttgagcc tgaaagagag 8820 ttcgacagaa tcaatttcgg tgtcgttgac ggcggcctgg cgcaaaatct cctgcacgtc 8880 tcctgagttg tcttgatagg cgatctcggc catgaactgc tcgatctctt cctcctggag 8940

atctccgcgt ccggctcgct ccacggtggc ggcgaggtcg ttggaaatgc gggccatgag 9000 ctgcgagaag gcgttgaggc ctccctcgtt ccagacgcgg ctgtagacca cgcccccttc 9060 ggcatcgcgg gcgcgcatga ccacctgcgc gagattgagc tccacgtgcc gggcgaagac 9120

ggcgtagttt cgcaggcgct gaaagaggta gttgagggtg gtggcggtgt gttctgccac 9180 gaagaagtac ataacccagc gtcgcaacgt ggattcgttg atatccccca aggcctcaag 9240 gcgctccatg gcctcgtaga agtccacggc gaagttgaaa aactgggagt tgcgcgccga 9300

cacggttaac tcctcctcca gaagacggat gagctcggcg acagtgtcgc gcacctcgcg 9360 ctcaaaggct acaggggcct cttcttcttc ttcaatctcc tcttccataa gggcctcccc 9420

ttcttcttct tctggcggcg gtgggggagg ggggacacgg cggcgacgac ggcgcaccgg 9480

gaggcggtcg acaaagcgct cgatcatctc cccgcggcga cggcgcatgg tctcggtgac 9540

ggcgcggccg ttctcgcggg ggcgcagttg gaagacgccg cccgtcatgt cccggttatg 9600

ggttggcggg gggctgccat gcggcaggga tacggcgcta acgatgcatc tcaacaattg 9660 ttgtgtaggt actccgccgc cgagggacct gagcgagtcc gcatcgaccg gatcggaaaa 9720

cctctcgaga aaggcgtcta accagtcaca gtcgcaaggt aggctgagca ccgtggcggg 9780

cggcagcggg cggcggtcgg ggttgtttct ggcggaggtg ctgctgatga tgtaattaaa 9840 gtaggcggtc ttgagacggc ggatggtcga cagaagcacc atgtccttgg gtccggcctg 9900

ctgaatgcgc aggcggtcgg ccatgcccca ggcttcgttt tgacatcggc gcaggtcttt 9960 gtagtagtct tgcatgagcc tttctaccgg cacttcttct tctccttcct cttgtcctgc 10020 atctcttgca tctatcgctg cggcggcggc ggagtttggc cgtaggtggc gccctcttcc 10080

tcccatgcgt gtgaccccga agcccctcat cggctgaagc agggctaggt cggcgacaac 10140 gcgctcggct aatatggcct gctgcacctg cgtgagggta gactggaagt catccatgtc 10200 cacaaagcgg tggtatgcgc ccgtgttgat ggtgtaagtg cagttggcca taacggacca 10260

gttaacggtc tggtgacccg gctgcgagag ctcggtgtac ctgagacgcg agtaagccct 10320 cgagtcaaat acgtagtcgt tgcaagtccg caccaggtac tggtatccca ccaaaaagtg 10380

cggcggcggc tggcggtaga ggggccagcg tagggtggcc ggggctccgg gggcgagatc 10440 ttccaacata aggcgatgat atccgtagat gtacctggac atccaggtga tgccggcggc 10500 ggtggtggag gcgcgcggaa agtcgcggac gcggttccag atgttgcgca gcggcaaaaa 10560

gtgctccatg gtcgggacgc tctggccggt caggcgcgcg caatcgttga cgctctagac 10620 Page 133

Sequence_Listing.txt cgtgcaaaag gagagcctgt aagcgggcac tcttccgtgg tctggtggat aaattcgcaa 10680

gggtatcatg gcggacgacc ggggttcgag ccccgtatcc ggccgtccgc cgtgatccat 10740 gcggttaccg cccgcgtgtc gaacccaggt gtgcgacgtc agacaacggg ggagtgctcc 10800

ttttggcttc cttccaggcg cggcggctgc tgcgctagct tttttggcca ctggccgcgc 10860 gcagcgtaag cggttaggct ggaaagcgaa agcattaagt ggctcgctcc ctgtagccgg 10920 agggttattt tccaagggtt gagtcgcggg acccccggtt cgagtctcgg accggccgga 10980

ctgcggcgaa cgggggtttg cctccccgtc atgcaagacc ccgcttgcaa attcctccgg 11040 aaacagggac gagccccttt tttgcttttc ccagatgcat ccggtgctgc ggcagatgcg 11100 cccccctcct cagcagcggc aagagcaaga gcagcggcag acatgcaggg caccctcccc 11160

tcctcctacc gcgtcaggag gggcgacatc cgcggttgac gcggcagcag atggtgatta 11220 cgaacccccg cggcgccggg cccggcacta cctggacttg gaggagggcg agggcctggc 11280 gcggctagga gcgccctctc ctgagcggta cccaagggtg cagctgaagc gtgatacgcg 11340

tgaggcgtac gtgccgcggc agaacctgtt tcgcgaccgc gagggagagg agcccgagga 11400 gatgcgggat cgaaagttcc acgcagggcg cgagctgcgg catggcctga atcgcgagcg 11460

gttgctgcgc gaggaggact ttgagcccga cgcgcgaacc gggattagtc ccgcgcgcgc 11520

acacgtggcg gccgccgacc tggtaaccgc atacgagcag acggtgaacc aggagattaa 11580

ctttcaaaaa agctttaaca accacgtgcg tacgcttgtg gcgcgcgagg aggtggctat 11640

aggactgatg catctgtggg actttgtaag cgcgctggag caaaacccaa atagcaagcc 11700 gctcatggcg cagctgttcc ttatagtgca gcacagcagg gacaacgagg cattcaggga 11760

tgcgctgcta aacatagtag agcccgaggg ccgctggctg ctcgatttga taaacatcct 11820

gcagagcata gtggtgcagg agcgcagctt gagcctggct gacaaggtgg ccgccatcaa 11880 ctattccatg cttagcctgg gcaagtttta cgcccgcaag atataccata ccccttacgt 11940

tcccatagac aaggaggtaa agatcgaggg gttctacatg cgcatggcgc tgaaggtgct 12000 taccttgagc gacgacctgg gcgtttatcg caacgagcgc atccacaagg ccgtgagcgt 12060 gagccggcgg cgcgagctca gcgaccgcga gctgatgcac agcctgcaaa gggccctggc 12120

tggcacgggc agcggcgata gagaggccga gtcctacttt gacgcgggcg ctgacctgcg 12180 ctgggcccca agccgacgcg ccctggaggc agctggggcc ggacctgggc tggcggtggc 12240 acccgcgcgc gctggcaacg tcggcggcgt ggaggaatat gacgaggacg atgagtacga 12300

gccagaggac ggcgagtact aagcggtgat gtttctgatc agatgatgca agacgcaacg 12360 gacccggcgg tgcgggcggc gctgcagagc cagccgtccg gccttaactc cacggacgac 12420

tggcgccagg tcatggaccg catcatgtcg ctgactgcgc gcaatcctga cgcgttccgg 12480 cagcagccgc aggccaaccg gctctccgca attctggaag cggtggtccc ggcgcgcgca 12540 aaccccacgc acgagaaggt gctggcgatc gtaaacgcgc tggccgaaaa cagggccatc 12600

cggcccgacg aggccggcct ggtctacgac gcgctgcttc agcgcgtggc tcgttacaac 12660 Page 134

Sequence_Listing.txt agcggcaacg tgcagaccaa cctggaccgg ctggtggggg atgtgcgcga ggccgtggcg 12720

cagcgtgagc gcgcgcagca gcagggcaac ctgggctcca tggttgcact aaacgccttc 12780 ctgagtacac agcccgccaa cgtgccgcgg ggacaggagg actacaccaa ctttgtgagc 12840

gcactgcggc taatggtgac tgagacaccg caaagtgagg tgtaccagtc tgggccagac 12900 tattttttcc agaccagtag acaaggcctg cagaccgtaa acctgagcca ggctttcaaa 12960 aacttgcagg ggctgtgggg ggtgcgggct cccacaggcg accgcgcgac cgtgtctagc 13020

ttgctgacgc ccaactcgcg cctgttgctg ctgctaatag cgcccttcac ggacagtggc 13080 agcgtgtccc gggacacata cctaggtcac ttgctgacac tgtaccgcga ggccataggt 13140 caggcgcatg tggacgagca tactttccag gagattacaa gtgtcagccg cgcgctgggg 13200

caggaggaca cgggcagcct ggaggcaacc ctaaactacc tgctgaccaa ccggcggcag 13260 aagatcccct cgttgcacag tttaaacagc gaggaggagc gcattttgcg ctacgtgcag 13320 cagagcgtga gccttaacct gatgcgcgac ggggtaacgc ccagcgtggc gctggacatg 13380

accgcgcgca acatggaacc gggcatgtat gcctcaaacc ggccgtttat caaccgccta 13440 atggactact tgcatcgcgc ggccgccgtg aaccccgagt atttcaccaa tgccatcttg 13500

aacccgcact ggctaccgcc ccctggtttc tacaccgggg gattcgaggt gcccgagggt 13560

aacgatggat tcctctggga cgacatagac gacagcgtgt tttccccgca accgcagacc 13620

ctgctagagt tgcaacagcg cgagcaggca gaggcggcgc tgcgaaagga aagcttccgc 13680

aggccaagca gcttgtccga tctaggcgct gcggccccgc ggtcagatgc tagtagccca 13740 tttccaagct tgatagggtc tcttaccagc actcgcacca cccgcccgcg cctgctgggc 13800

gaggaggagt acctaaacaa ctcgctgctg cagccgcagc gcgaaaaaaa cctgcctccg 13860

gcatttccca acaacgggat agagagccta gtggacaaga tgagtagatg gaagacgtac 13920 gcgcaggagc acagggacgt gccaggcccg cgcccgccca cccgtcgtca aaggcacgac 13980

cgtcagcggg gtctggtgtg ggaggacgat gactcggcag acgacagcag cgtcctggat 14040 ttgggaggga gtggcaaccc gtttgcgcac cttcgcccca ggctggggag aatgttttaa 14100 aaaaaaaaaa gcatgatgca aaataaaaaa ctcaccaagg ccatggcacc gagcgttggt 14160

tttcttgtat tccccttagt atgcggcgcg cggcgatgta tgaggaaggt cctcctccct 14220 cctacgagag tgtggtgagc gcggcgccag tggcggcggc gctgggttct cccttcgatg 14280 ctcccctgga cccgccgttt gtgcctccgc ggtacctgcg gcctaccggg gggagaaaca 14340

gcatccgtta ctctgagttg gcacccctat tcgacaccac ccgtgtgtac ctggtggaca 14400 acaagtcaac ggatgtggca tccctgaact accagaacga ccacagcaac tttctgacca 14460

cggtcattca aaacaatgac tacagcccgg gggaggcaag cacacagacc atcaatcttg 14520 acgaccggtc gcactggggc ggcgacctga aaaccatcct gcataccaac atgccaaatg 14580 tgaacgagtt catgtttacc aataagttta aggcgcgggt gatggtgtcg cgcttgccta 14640

ctaaggacaa tcaggtggag ctgaaatacg agtgggtgga gttcacgctg cccgagggca 14700 Page 135

Sequence_Listing.txt actactccga gaccatgacc atagacctta tgaacaacgc gatcgtggag cactacttga 14760

aagtgggcag acagaacggg gttctggaaa gcgacatcgg ggtaaagttt gacacccgca 14820 acttcagact ggggtttgac cccgtcactg gtcttgtcat gcctggggta tatacaaacg 14880

aagccttcca tccagacatc attttgctgc caggatgcgg ggtggacttc acccacagcc 14940 gcctgagcaa cttgttgggc atccgcaagc ggcaaccctt ccaggagggc tttaggatca 15000 cctacgatga tctggagggt ggtaacattc ccgcactgtt ggatgtggac gcctaccagg 15060

cgagcttgaa agatgacacc gaacagggcg ggggtggcgc aggcggcagc aacagcagtg 15120 gcagcggcgc ggaagagaac tccaacgcgg cagccgcggc aatgcagccg gtggaggaca 15180 tgaacgatca tgccattcgc ggcgacacct ttgccacacg ggctgaggag aagcgcgctg 15240

aggccgaagc agcggccgaa gctgccgccc ccgctgcgca acccgaggtc gagaagcctc 15300 agaagaaacc ggtgatcaaa cccctgacag aggacagcaa gaaacgcagt tacaacctaa 15360 taagcaatga cagcaccttc acccagtacc gcagctggta ccttgcatac aactacggcg 15420

accctcagac cggaatccgc tcatggaccc tgctttgcac tcctgacgta acctgcggct 15480 cggagcaggt ctactggtcg ttgccagaca tgatgcaaga ccccgtgacc ttccgctcca 15540

cgcgccagat cagcaacttt ccggtggtgg gcgccgagct gttgcccgtg cactccaaga 15600

gcttctacaa cgaccaggcc gtctactccc aactcatccg ccagtttacc tctctgaccc 15660

acgtgttcaa tcgctttccc gagaaccaga ttttggcgcg cccgccagcc cccaccatca 15720

ccaccgtcag tgaaaacgtt cctgctctca cagatcacgg gacgctaccg ctgcgcaaca 15780 gcatcggagg agtccagcga gtgaccatta ctgacgccag acgccgcacc tgcccctacg 15840

tttacaaggc cctgggcata gtctcgccgc gcgtcctatc gagccgcact ttttgagcaa 15900

gcatgtccat ccttatatcg cccagcaata acacaggctg gggcctgcgc ttcccaagca 15960 agatgtttgg cggggccaag aagcgctccg accaacaccc agtgcgcgtg cgcgggcact 16020

accgcgcgcc ctggggcgcg cacaaacgcg gccgcactgg gcgcaccacc gtcgatgacg 16080 ccatcgacgc ggtggtggag gaggcgcgca actacacgcc cacgccgcca ccagtgtcca 16140 cagtggacgc ggccattcag accgtggtgc gcggagcccg gcgctatgct aaaatgaaga 16200

gacggcggag gcgcgtagca cgtcgccacc gccgccgacc cggcactgcc gcccaacgcg 16260 cggcggcggc cctgcttaac cgcgcacgtc gcaccggccg acgggcggcc atgcgggccg 16320 ctcgaaggct ggccgcgggt attgtcactg tgccccccag gtccaggcga cgagcggccg 16380

ccgcagcagc cgcggccatt agtgctatga ctcagggtcg caggggcaac gtgtattggg 16440 tgcgcgactc ggttagcggc ctgcgcgtgc ccgtgcgcac ccgccccccg cgcaactaga 16500

ttgcaagaaa aaactactta gactcgtact gttgtatgta tccagcggcg gcggcgcgca 16560 acgaagctat gtccaagcgc aaaatcaaag aagagatgct ccaggtcatc gcgccggaga 16620 tctatggccc cccgaagaag gaagagcagg attacaagcc ccgaaagcta aagcgggtca 16680

aaaagaaaaa gaaagatgat gatgatgaac ttgacgacga ggtggaactg ctgcacgcta 16740 Page 136

Sequence_Listing.txt ccgcgcccag gcgacgggta cagtggaaag gtcgacgcgt aaaacgtgtt ttgcgacccg 16800

gcaccaccgt agtctttacg cccggtgagc gctccacccg cacctacaag cgcgtgtatg 16860 atgaggtgta cggcgacgag gacctgcttg agcaggccaa cgagcgcctc ggggagtttg 16920

cctacggaaa gcggcataag gacatgctgg cgttgccgct ggacgagggc aacccaacac 16980 ctagcctaaa gcccgtaaca ctgcagcagg tgctgcccgc gcttgcaccg tccgaagaaa 17040 agcgcggcct aaagcgcgag tctggtgact tggcacccac cgtgcagctg atggtaccca 17100

agcgccagcg actggaagat gtcttggaaa aaatgaccgt ggaacctggg ctggagcccg 17160 aggtccgcgt gcggccaatc aagcaggtgg cgccgggact gggcgtgcag accgtggacg 17220 ttcagatacc cactaccagt agcaccagta ttgccaccgc cacagagggc atggagacac 17280

aaacgtcccc ggttgcctca gcggtggcgg atgccgcggt gcaggcggtc gctgcggccg 17340 cgtccaagac ctctacggag gtgcaaacgg acccgtggat gtttcgcgtt tcagcccccc 17400 ggcgcccgcg cggttcgagg aagtacggcg ccgccagcgc gctactgccc gaatatgccc 17460

tacatccttc cattgcgcct acccccggct atcgtggcta cacctaccgc cccagaagac 17520 gagcaactac ccgacgccga accaccactg gaacccgccg ccgccgtcgc cgtcgccagc 17580

ccgtgctggc cccgatttcc gtgcgcaggg tggctcgcga aggaggcagg accctggtgc 17640

tgccaacagc gcgctaccac cccagcatcg tttaaaagcc ggtctttgtg gttcttgcag 17700

atatggccct cacctgccgc ctccgtttcc cggtgccggg attccgagga agaatgcacc 17760

gtaggagggg catggccggc cacggcctga cgggcggcat gcgtcgtgcg caccaccggc 17820 ggcggcgcgc gtcgcaccgt cgcatgcgcg gcggtatcct gcccctcctt attccactga 17880

tcgccgcggc gattggcgcc gtgcccggaa ttgcatccgt ggccttgcag gcgcagagac 17940

actgattaaa aacaagttgc atgtggaaaa atcaaaataa aaagtctgga ctctcacgct 18000 cgcttggtcc tgtaactatt ttgtagaatg gaagacatca actttgcgtc tctggccccg 18060

cgacacggct cgcgcccgtt catgggaaac tggcaagata tcggcaccag caatatgagc 18120 ggtggcgcct tcagctgggg ctcgctgtgg agcggcatta aaaatttcgg ttccaccgtt 18180 aagaactatg gcagcaaggc ctggaacagc agcacaggcc agatgctgag ggataagttg 18240

aaagagcaaa atttccaaca aaaggtggta gatggcctgg cctctggcat tagcggggtg 18300 gtggacctgg ccaaccaggc agtgcaaaat aagattaaca gtaagcttga tccccgccct 18360 cccgtagagg agcctccacc ggccgtggag acagtgtctc cagaggggcg tggcgaaaag 18420

cgtccgcgcc ccgacaggga agaaactctg gtgacgcaaa tagacgagcc tccctcgtac 18480 gaggaggcac taaagcaagg cctgcccacc acccgtccca tcgcgcccat ggctaccgga 18540

gtgctgggcc agcacacacc cgtaacgctg gacctgcctc cccccgccga cacccagcag 18600 aaacctgtgc tgccaggccc gaccgccgtt gttgtaaccc gtcctagccg cgcgtccctg 18660 cgccgcgccg ccagcggtcc gcgatcgttg cggcccgtag ccagtggcaa ctggcaaagc 18720

acactgaaca gcatcgtggg tctgggggtg caatccctga agcgccgacg atgcttctga 18780 Page 137

Sequence_Listing.txt atagctaacg tgtcgtatgt gtgtcatgta tgcgtccatg tcgccgccag aggagctgct 18840

gagccgccgc gcgcccgctt tccaagatgg ctaccccttc gatgatgccg cagtggtctt 18900 acatgcacat ctcgggccag gacgcctcgg agtacctgag ccccgggctg gtgcagtttg 18960

cccgcgccac cgagacgtac ttcagcctga ataacaagtt tagaaacccc acggtggcgc 19020 ctacgcacga cgtgaccaca gaccggtccc agcgtttgac gctgcggttc atccctgtgg 19080 accgtgagga tactgcgtac tcgtacaagg cgcggttcac cctagctgtg ggtgataacc 19140

gtgtgctgga catggcttcc acgtactttg acatccgcgg cgtgctggac aggggcccta 19200 cttttaagcc ctactctggc actgcctaca acgccctggc tcccaagggt gccccaaatc 19260 cttgcgaatg ggatgaagct gctactgctc ttgaaataaa cctagaagaa gaggacgatg 19320

acaacgaaga cgaagtagac gagcaagctg agcagcaaaa aactcacgta tttgggcagg 19380 cgccttattc tggtataaat attacaaagg agggtattca aataggtgtc gaaggtcaaa 19440 cacctaaata tgccgataaa acatttcaac ctgaacctca aataggagaa tctcagtggt 19500

acgaaactga aattaatcat gcagctggga gagtccttaa aaagactacc ccaatgaaac 19560 catgttacgg ttcatatgca aaacccacaa atgaaaatgg agggcaaggc attcttgtaa 19620

agcaacaaaa tggaaagcta gaaagtcaag tggaaatgca atttttctca actactgagg 19680

cgaccgcagg caatggtgat aacttgactc ctaaagtggt attgtacagt gaagatgtag 19740

atatagaaac cccagacact catatttctt acatgcccac tattaaggaa ggtaactcac 19800

gagaactaat gggccaacaa tctatgccca acaggcctaa ttacattgct tttagggaca 19860 attttattgg tctaatgtat tacaacagca cgggtaatat gggtgttctg gcgggccaag 19920

catcgcagtt gaatgctgtt gtagatttgc aagacagaaa cacagagctt tcataccagc 19980

ttttgcttga ttccattggt gatagaacca ggtacttttc tatgtggaat caggctgttg 20040 acagctatga tccagatgtt agaattattg aaaatcatgg aactgaagat gaacttccaa 20100

attactgctt tccactggga ggtgtgatta atacagagac tcttaccaag gtaaaaccta 20160 aaacaggtca ggaaaatgga tgggaaaaag atgctacaga attttcagat aaaaatgaaa 20220 taagagttgg aaataatttt gccatggaaa tcaatctaaa tgccaacctg tggagaaatt 20280

tcctgtactc caacatagcg ctgtatttgc ccgacaagct aaagtacagt ccttccaacg 20340 taaaaatttc tgataaccca aacacctacg actacatgaa caagcgagtg gtggctcccg 20400 ggttagtgga ctgctacatt aaccttggag cacgctggtc ccttgactat atggacaacg 20460

tcaacccatt taaccaccac cgcaatgctg gcctgcgcta ccgctcaatg ttgctgggca 20520 atggtcgcta tgtgcccttc cacatccagg tgcctcagaa gttctttgcc attaaaaacc 20580

tccttctcct gccgggctca tacacctacg agtggaactt caggaaggat gttaacatgg 20640 ttctgcagag ctccctagga aatgacctaa gggttgacgg agccagcatt aagtttgata 20700 gcatttgcct ttacgccacc ttcttcccca tggcccacaa caccgcctcc acgcttgagg 20760

ccatgcttag aaacgacacc aacgaccagt cctttaacga ctatctctcc gccgccaaca 20820 Page 138

Sequence_Listing.txt tgctctaccc tatacccgcc aacgctacca acgtgcccat atccatcccc tcccgcaact 20880

gggcggcttt ccgcggctgg gccttcacgc gccttaagac taaggaaacc ccatcactgg 20940 gctcgggcta cgacccttat tacacctact ctggctctat accctaccta gatggaacct 21000

tttacctcaa ccacaccttt aagaaggtgg ccattacctt tgactcttct gtcagctggc 21060 ctggcaatga ccgcctgctt acccccaacg agtttgaaat taagcgctca gttgacgggg 21120 agggttacaa cgttgcccag tgtaacatga ccaaagactg gttcctggta caaatgctag 21180

ctaactacaa cattggctac cagggcttct atatcccaga gagctacaag gaccgcatgt 21240 actccttctt tagaaacttc cagcccatga gccgtcaggt ggtggatgat actaaataca 21300 aggactacca acaggtgggc atcctacacc aacacaacaa ctctggattt gttggctacc 21360

ttgcccccac catgcgcgaa ggacaggcct accctgctaa cttcccctat ccgcttatag 21420 gcaagaccgc agttgacagc attacccaga aaaagtttct ttgcgatcgc accctttggc 21480 gcatcccatt ctccagtaac tttatgtcca tgggcgcact cacagacctg ggccaaaacc 21540

ttctctacgc caactccgcc cacgcgctag acatgacttt tgaggtggat cccatggacg 21600 agcccaccct tctttatgtt ttgtttgaag tctttgacgt ggtccgtgtg caccggccgc 21660

accgcggcgt catcgaaacc gtgtacctgc gcacgccctt ctcggccggc aacgccacaa 21720

cataaagaag caagcaacat caacaacagc tgccgccatg ggctccagtg agcaggaact 21780

gaaagccatt gtcaaagatc ttggttgtgg gccatatttt ttgggcacct atgacaagcg 21840

ctttccaggc tttgtttctc cacacaagct cgcctgcgcc atagtcaata cggccggtcg 21900 cgagactggg ggcgtacact ggatggcctt tgcctggaac ccgcactcaa aaacatgcta 21960

cctctttgag ccctttggct tttctgacca gcgactcaag caggtttacc agtttgagta 22020

cgagtcactc ctgcgccgta gcgccattgc ttcttccccc gaccgctgta taacgctgga 22080 aaagtccacc caaagcgtac aggggcccaa ctcggccgcc tgtggactat tctgctgcat 22140

gtttctccac gcctttgcca actggcccca aactcccatg gatcacaacc ccaccatgaa 22200 ccttattacc ggggtaccca actccatgct caacagtccc caggtacagc ccaccctgcg 22260 tcgcaaccag gaacagctct acagcttcct ggagcgccac tcgccctact tccgcagcca 22320

cagtgcgcag attaggagcg ccacttcttt ttgtcacttg aaaaacatgt aaaaataatg 22380 tactagagac actttcaata aaggcaaatg cttttatttg tacactctcg ggtgattatt 22440 tacccccacc cttgccgtct gcgccgttta aaaatcaaag gggttctgcc gcgcatcgct 22500

atgcgccact ggcagggaca cgttgcgata ctggtgttta gtgctccact taaactcagg 22560 cacaaccatc cgcggcagct cggtgaagtt ttcactccac aggctgcgca ccatcaccaa 22620

cgcgtttagc aggtcgggcg ccgatatctt gaagtcgcag ttggggcctc cgccctgcgc 22680 gcgcgagttg cgatacacag ggttgcagca ctggaacact atcagcgccg ggtggtgcac 22740 gctggccagc acgctcttgt cggagatcag atccgcgtcc aggtcctccg cgttgctcag 22800

ggcgaacgga gtcaactttg gtagctgcct tcccaaaaag ggcgcgtgcc caggctttga 22860 Page 139

Sequence_Listing.txt gttgcactcg caccgtagtg gcatcaaaag gtgaccgtgc ccggtctggg cgttaggata 22920

cagcgcctgc ataaaagcct tgatctgctt aaaagccacc tgagcctttg cgccttcaga 22980 gaagaacatg ccgcaagact tgccggaaaa ctgattggcc ggacaggccg cgtcgtgcac 23040

gcagcacctt gcgtcggtgt tggagatctg caccacattt cggccccacc ggttcttcac 23100 gatcttggcc ttgctagact gctccttcag cgcgcgctgc ccgttttcgc tcgtcacatc 23160 catttcaatc acgtgctcct tatttatcat aatgcttccg tgtagacact taagctcgcc 23220

ttcgatctca gcgcagcggt gcagccacaa cgcgcagccc gtgggctcgt gatgcttgta 23280 ggtcacctct gcaaacgact gcaggtacgc ctgcaggaat cgccccatca tcgtcacaaa 23340 ggtcttgttg ctggtgaagg tcagctgcaa cccgcggtgc tcctcgttca gccaggtctt 23400

gcatacggcc gccagagctt ccacttggtc aggcagtagt ttgaagttcg cctttagatc 23460 gttatccacg tggtacttgt ccatcagcgc gcgcgcagcc tccatgccct tctcccacgc 23520 agacacgatc ggcacactca gcgggttcat caccgtaatt tcactttccg cttcgctggg 23580

ctcttcctct tcctcttgcg tccgcatacc acgcgccact gggtcgtctt cattcagccg 23640 ccgcactgtg cgcttacctc ctttgccatg cttgattagc accggtgggt tgctgaaacc 23700

caccatttgt agcgccacat cttctctttc ttcctcgctg tccacgatta cctctggtga 23760

tggcgggcgc tcgggcttgg gagaagggcg cttctttttc ttcttgggcg caatggccaa 23820

atccgccgcc gaggtcgatg gccgcgggct gggtgtgcgc ggcaccagcg cgtcttgtga 23880

tgagtcttcc tcgtcctcgg actcgatacg ccgcctcatc cgcttttttg ggggcgcccg 23940 gggaggcggc ggcgacgggg acggggacga cacgtcctcc atggttgggg gacgtcgcgc 24000

cgcaccgcgt ccgcgctcgg gggtggtttc gcgctgctcc tcttcccgac tggccatttc 24060

cttctcctat aggcagaaaa agatcatgga gtcagtcgag aagaaggaca gcctaaccgc 24120 cccctctgag ttcgccacca ccgcctccac cgatgccgcc aacgcgccta ccaccttccc 24180

cgtcgaggca cccccgcttg aggaggagga agtgattatc gagcaggacc caggttttgt 24240 aagcgaagac gacgaggacc gctcagtacc aacagaggat aaaaagcaag accaggacaa 24300 cgcagaggca aacgaggaac aagtcgggcg gggggacgaa aggcatggcg actacctaga 24360

tgtgggagac gacgtgctgt tgaagcatct gcagcgccag tgcgccatta tctgcgacgc 24420 gttgcaagag cgcagcgatg tgcccctcgc catagcggat gtcagccttg cctacgaacg 24480 ccacctattc tcaccgcgcg taccccccaa acgccaagaa aacggcacat gcgagcccaa 24540

cccgcgcctc aacttctacc ccgtatttgc cgtgccagag gtgcttgcca cctatcacat 24600 ctttttccaa aactgcaaga tacccctatc ctgccgtgcc aaccgcagcc gagcggacaa 24660

gcagctggcc ttgcggcagg gcgctgtcat acctgatatc gcctcgctca acgaagtgcc 24720 aaaaatcttt gagggtcttg gacgcgacga gaagcgcgcg gcaaacgctc tgcaacagga 24780 aaacagcgaa aatgaaagtc actctggagt gttggtggaa ctcgagggtg acaacgcgcg 24840

cctagccgta ctaaaacgca gcatcgaggt cacccacttt gcctacccgg cacttaacct 24900 Page 140

Sequence_Listing.txt accccccaag gtcatgagca cagtcatgag tgagctgatc gtgcgccgtg cgcagcccct 24960

ggagagggat gcaaatttgc aagaacaaac agaggagggc ctacccgcag ttggcgacga 25020 gcagctagcg cgctggcttc aaacgcgcga gcctgccgac ttggaggagc gacgcaaact 25080

aatgatggcc gcagtgctcg ttaccgtgga gcttgagtgc atgcagcggt tctttgctga 25140 cccggagatg cagcgcaagc tagaggaaac attgcactac acctttcgac agggctacgt 25200 acgccaggcc tgcaagatct ccaacgtgga gctctgcaac ctggtctcct accttggaat 25260

tttgcacgaa aaccgccttg ggcaaaacgt gcttcattcc acgctcaagg gcgaggcgcg 25320 ccgcgactac gtccgcgact gcgtttactt atttctatgc tacacctggc agacggccat 25380 gggcgtttgg cagcagtgct tggaggagtg caacctcaag gagctgcaga aactgctaaa 25440

gcaaaacttg aaggacctat ggacggcctt caacgagcgc tccgtggccg cgcacctggc 25500 ggacatcatt ttccccgaac gcctgcttaa aaccctgcaa cagggtctgc cagacttcac 25560 cagtcaaagc atgttgcaga actttaggaa ctttatccta gagcgctcag gaatcttgcc 25620

cgccacctgc tgtgcacttc ctagcgactt tgtgcccatt aagtaccgcg aatgccctcc 25680 gccgctttgg ggccactgct accttctgca gctagccaac taccttgcct accactctga 25740

cataatggaa gacgtgagcg gtgacggtct actggagtgt cactgtcgct gcaacctatg 25800

caccccgcac cgctccctgg tttgcaattc gcagctgctt aacgaaagtc aaattatcgg 25860

tacctttgag ctgcagggtc cctcgcctga cgaaaagtcc gcggctccgg ggttgaaact 25920

cactccgggg ctgtggacgt cggcttacct tcgcaaattt gtacctgagg actaccacgc 25980 ccacgagatt aggttctacg aagaccaatc ccgcccgcca aatgcggagc ttaccgcctg 26040

cgtcattacc cagggccaca ttcttggcca attgcaagcc atcaacaaag cccgccaaga 26100

gtttctgcta cgaaagggac ggggggttta cttggacccc cagtccggcg aggagctcaa 26160 cccaatcccc ccgccgccgc agccctatca gcagcagccg cgggcccttg cttcccagga 26220

tggcacccaa aaagaagctg cagctgccgc cgccacccac ggacgaggag gaatactggg 26280 acagtcaggc agaggaggtt ttggacgagg aggaggagga catgatggaa gactgggaga 26340 gcctagacga ggaagcttcc gaggtcgaag aggtgtcaga cgaaacaccg tcaccctcgg 26400

tcgcattccc ctcgccggcg ccccagaaat cggcaaccgg ttccagcatg gctacaacct 26460 ccgctcctca ggcgccgccg gcactgcccg ttcgccgacc caaccgtaga tgggacacca 26520 ctggaaccag ggccggtaag tccaagcagc cgccgccgtt agcccaagag caacaacagc 26580

gccaaggcta ccgctcatgg cgcgggcaca agaacgccat agttgcttgc ttgcaagact 26640 gtgggggcaa catctccttc gcccgccgct ttcttctcta ccatcacggc gtggccttcc 26700

cccgtaacat cctgcattac taccgtcatc tctacagccc atactgcacc ggcggcagcg 26760 gcagcggcag caacagcagc ggccacacag aagcaaaggc gaccggatag caagactctg 26820 acaaagccca agaaatccac agcggcggca gcagcaggag gaggagcgct gcgtctggcg 26880

cccaacgaac ccgtatcgac ccgcgagctt agaaacagga tttttcccac tctgtatgct 26940 Page 141

Sequence_Listing.txt atatttcaac agagcagggg ccaagaacaa gagctgaaaa taaaaaacag gtctctgcga 27000

tccctcaccc gcagctgcct gtatcacaaa agcgaagatc agcttcggcg cacgctggaa 27060 gacgcggagg ctctcttcag taaatactgc gcgctgactc ttaaggacta gtttcgcgcc 27120

ctttctcaaa tttaagcgcg aaaactacgt catctccagc ggccacaccc ggcgccagca 27180 cctgtcgtca gcgccatttc aactttgtat acaaaagttg tgatgagcaa ggaaattccc 27240 acgccctaca tgtggagtta ccagccacaa atgggacttg cggctggagc tgcccaagac 27300

tactcaaccc gaataaacta catgagcgcg ggaccccaca tgatatcccg ggtcaacgga 27360 atacgcgccc accgaaaccg aattctcctg gaacaggcgg ctattaccac cacacctcgt 27420 aataacctta atccccgtag ttggcccgct gccctggtgt accaggaaag tcccgctccc 27480

accactgtgg tacttcccag agacgcccag gccgaagttc agatgactaa ctcaggggcg 27540 cagcttgcgg gcggctttcg tcacagggtg cggtcgcccg ggcagggtat aactcacctg 27600 acaatcagag ggcgaggtat tcagctcaac gacgagtcgg tgagctcctc gcttggtctc 27660

cgtccggacg ggacatttca gatcggcggc gccggccgct cttcattcac gcctcgtcag 27720 gcaatcctaa ctctgcagac ctcgtcctct gagccgcgct ctggaggcat tggaactctg 27780

caatttattg aggagtttgt gccatcggtc tactttaacc ccttctcggg acctcccggc 27840

cactatccgg atcaatttat tcctaacttt gacgcggtaa aggactcggc ggacggctac 27900

gactgaatgt taagtggaga ggcagagcaa ctgcgcctga aacacctggt ccactgtcgc 27960

cgccacaagt gctttgcccg cgactccggt gagttttgct actttgaatt gcccgaggat 28020 catatcgagg gcccggcgca cggcgtccgg cttaccgccc agggagagct tgcccgtagc 28080

ctgattcggg agtttaccca gcgccccctg ctagttgagc gggacagggg accctgtgtt 28140

ctcactgtga tttgcaactg tcctaaccct ggattacatc aagatctttg ttgccatctc 28200 tgtgctgagt ataataaata cagaaattaa aatatactgg ggctcctatc gccatcctgt 28260

aaacgccacc gtcttcaccc gcccaagcaa accaaggcga accttacctg gtacttttaa 28320 catctctccc tctgtgattt acaacagttt caacccagac ggagtgagtc tacgagagaa 28380 cctctccgag ctcagctact ccatcagaaa aaacaccacc ctccttacct gccgggaacg 28440

tacgagtgcg tcaccggccg ctgcaccaca cctaccgcct gaccgtaaac cagacttttt 28500 ccggacagac ctcaataact ctgtttacca gaacaggagg tgagcttaga aaacccttag 28560 ggtattaggc caaaggcgca gctactgtgg ggtttatgaa caattcaagc aactctacgg 28620

gctattctaa ttcaggtttc tctagaatcg gggttggggt tattctctgt cttgtgattc 28680 tctttattct tatactaacg cttctctgcc taaggctcgc cgcctgctgt gtgcacattt 28740

gcatttattg tcagcttttt aaacgctggg gtcgccaccc aagatgatta ggtacataat 28800 cctaggttta ctcacccttg cgtcagccca cggtaccacc caaaaggtgg attttaagga 28860 gccagcctgt aatgttacat tcgcagctga agctaatgag tgcaccactc ttataaaatg 28920

caccacagaa catgaaaagc tgcttattcg ccacaaaaac aaaattggca agtatgctgt 28980 Page 142

Sequence_Listing.txt ttatgctatt tggcagccag gtgacactac agagtataat gttacagttt tccagggtaa 29040

aagtcataaa acttttatgt atacttttcc attttatgaa atgtgcgaca ttaccatgta 29100 catgagcaaa cagtataagt tgtggccccc acaaaattgt gtggaaaaca ctggcacttt 29160

ctgctgcact gctatgctaa ttacagtgct cgctttggtc tgtaccctac tctatattaa 29220 atacaaaagc agacgcagct ttattgagga aaagaaaatg ccttaattta ctaagttaca 29280 aagctaatgt caccactaac tgctttactc gctgcttgca aaacaaattc aaaaagttag 29340

cattataatt agaataggat ttaaaccccc cggtcatttc ctgctcaata ccattcccct 29400 gaacaattga ctctatgtgg gatatgctcc agcgctacaa ccttgaagtc aggcttcctg 29460 gatgtcagca tctgactttg gccagcacct gtcccgcgga tttgttccag tccaactaca 29520

gcgacccacc ctaacagaga tgaccaacac aaccaacgcg gccgccgcta ccggacttac 29580 atctaccaca aatacacccc aagtttctgc ctttgtcaat aactgggata acttgggcat 29640 gtggtggttc tccatagcgc ttatgtttgt atgccttatt attatgtggc tcatctgctg 29700

cctaaagcgc aaacgcgccc gaccacccat ctatagtccc atcattgtgc tacacccaaa 29760 caatgatgga atccatagat tggacggact gaaacacatg ttcttttctc ttacagtagg 29820

aagcggagct actaacttca gcctgctgaa gcaggctggt gacgtcgagg agaatcctgg 29880

cccaatggtg agcaaaggcg aagagctgtt caccggcgtg gtgcccatcc tggtggagct 29940

ggacggcgac gtgaacggcc acaagttcag cgtgagcggc gagggcgagg gcgacgccac 30000

ctacggcaag ctgaccctga agctgctgtg caccaccggc aagctgcccg tgccctggcc 30060 caccctggtg accaccctgg gctacggcgt gcagtgcttc gcccggtacc ccgaccacat 30120

gaagcagcac gacttcttca agagcgccat gcccgagggc tacgtgcagg agcggaccat 30180

cttcttcaag gacgacggca actacaagac ccgggccgag gtgaagttcg agggcgacac 30240 cctggtgaac cggatcgagc tgaagggcat cgacttcaag gaggacggca acatcctggg 30300

ccacaagctg gagtacaact acaacagcca caacgtgtac atcaccgccg acaagcagaa 30360 gaacggcatc aaggccaact tcaagatccg gcacaacatc gaggacggcg gcgtgcagct 30420 ggccgaccac taccagcaga acacccccat cggcgacggc cccgtgctgc tgcccgacaa 30480

ccactacctg agctaccaga gcgccctgtt caaggacccc aacgagaagc gggaccacat 30540 ggtgctgctg gagttcctga ccgccgccgg catcaccgag ggcatgaacg agctctataa 30600 gtgattaaat gagacatgat tcctcgagtt tttatattac tgacccttgt tgcgcttttt 30660

tgtgcgtgct ccacattggc tgcggtttct cacatcgaag tagactgcat tccagccttc 30720 acagtctatt tgctttacgg atttgtcacc ctcacgctca tctgcagcct catcactgtg 30780

gtcatcgcct ttatccagtg cattgactgg gtctgtgtgc gctttgcata tctcagacac 30840 catccccagt acagggacag gactatagct gagcttctta gaattcttta attatgaaat 30900 ttactgtgac ttttctgctg attatttgca ccctatctgc gttttgttcc ccgacctcca 30960

agcctcaaag acatatatca tgcagattca ctcgtatatg gaatattcca agttgctaca 31020 Page 143

Sequence_Listing.txt atgaaaaaag cgatctttcc gaagcctggt tatatgcaat catctctgtt atggtgttct 31080

gcagtaccat cttagcccta gctatatatc cctaccttga cattggctgg aacgcaatag 31140 atgccatgaa ccacccaact ttccccgcgc ccgctatgct tccactgcaa caagttgttg 31200

ccggcggctt tgtcccagcc aatcagcctc gcccaccttc tcccaccccc actgaaatca 31260 gctactttaa tctaacagga ggagatgact gacaccctag atctagaaat ggacggaatt 31320 attacagagc agcgcctgct agaaagacgc agggcagcgg ccgagcaaca gcgcatgaat 31380

caagagctcc aagacatggt taacttgcac cagtgcaaaa ggggtatctt ttgtctggta 31440 aagcaggcca aagtcaccta cgacagtaat accaccggac accgccttag ctacaagttg 31500 ccaaccaagc gtcagaaatt ggtggtcatg gtgggagaaa agcccattac cataactcag 31560

cactcggtag aaaccgaagg ctgcattcac tcaccttgtc aaggacctga ggatctctgc 31620 acccttatta agaccctgtg cggtctcaaa gatcttattc cctttaacta ataaaaaaaa 31680 ataataaagc atcacttact taaaatcagt tagcaaattt ctgtccagtt tattcagcag 31740

cacctccttg ccctcctccc agctctggta ttgcagcttc ctcctggctg caaactttct 31800 ccacaatcta aatggaatgt cagtttcctc ctgttcctgt ccatccgcac ccactatctt 31860

catgttgttg cagatgaagc gcgcaagacc gtctgaagat accttcaacc ccgtgtatcc 31920

atatgacacg gaaaccggtc ctccaactgt gccttttctt actcctccct ttgtatcccc 31980

caatgggttt caagagagtc cccctggggt actctctttg cgcctatccg aacctctagt 32040

tacctccaat ggcatgcttg cgctcaaaat gggcaacggc ctctctctgg acgaggccgg 32100 caaccttacc tcccaaaatg taaccactgt gagcccacct ctcaaaaaaa ccaagtcaaa 32160

cataaacctg gaaatatctg cacccctcac agttacctca gaagccctaa ctgtggctgc 32220

cgccgcacct ctaatggtcg cgggcaacac actcaccatg caatcacagg ccccgctaac 32280 cgtgcacgac tccaaactta gcattgccac ccaaggaccc ctcacagtgt cagaaggaaa 32340

gctagccctg caaacatcag gccccctcac caccaccgat agcagtaccc ttactatcac 32400 tgcctcaccc cctctaacta ctgccactgg tagcttgggc attgacttga aagagcccat 32460 ttatacacaa aatggaaaac taggactaaa gtacggggct cctttgcatg taacagacga 32520

cctaaacact ttgaccgtag caactggtcc aggtgtgact attaataata cttccttgca 32580 aactaaagtt actggagcct tgggttttga ttcacaaggc aatatgcaac ttaatgtagc 32640 aggaggacta aggattgatt ctcaaaacag acgccttata cttgatgtta gttatccgtt 32700

tgatgctcaa aaccaactaa atctaagact aggacagggc cctcttttta taaactcagc 32760 ccacaacttg gatattaact acaacaaagg cctttacttg tttacagctt caaacaattc 32820

caaaaagctt gaggttaacc taagcactgc caaggggttg atgtttgacg ctacagccat 32880 agccattaat gcaggagatg ggcttgaatt tggttcacct aatgcaccaa acacaaatcc 32940 cctcaaaaca aaaattggcc atggcctaga atttgattca aacaaggcta tggttcctaa 33000

actaggaact ggccttagtt ttgacagcac aggtgccatt acagtaggaa acaaaaataa 33060 Page 144

Sequence_Listing.txt tgataagcta actttgtgga ccacaccagc tccatctcct aactgtagac taaatgcaga 33120

gaaagatgct aaactcactt tggtcttaac aaaatgtggc agtcaaatac ttgctacagt 33180 ttcagttttg gctgttaaag gcagtttggc tccaatatct ggaacagttc aaagtgctca 33240

tcttattata agatttgacg aaaatggagt gctactaaac aattccttcc tggacccaga 33300 atattggaac tttagaaatg gagatcttac tgaaggcaca gcctatacaa acgctgttgg 33360 atttatgcct aacctatcag cttatccaaa atctcacggt aaaactgcca aaagtaacat 33420

tgtcagtcaa gtttacttaa acggagacaa aactaaacct gtaacactaa ccattacact 33480 aaacggtaca caggaaacag gagacacaac tccaagtgca tactctatgt cattttcatg 33540 ggactggtct ggccacaact acattaatga aatatttgcc acatcctctt acactttttc 33600

atacattgcc caagaataaa gaatcgtttg tgttatgttt caacgtgttt atttttcaat 33660 tgcagaaaat ttcgaatcat ttttcattca gtagtatagc cccaccacca catagcttat 33720 acagatcacc gtacctcaac tttgtataat aaagttgtaa tcaaactcac agaaccctag 33780

tattcaacct gccacctccc tcccaacaca cagagtacac agtcctttct ccccggctgg 33840 ccttaaaaag catcatatca tgggtaacag acatattctt aggtgttata ttccacacgg 33900

tttcctgtcg agccaaacgc tcatcagtga tattaataaa ctccccgggc agctcactta 33960

agttcatgtc gctgtccagc tgctgagcca caggctgctg tccaacttgc ggttgcttaa 34020

cgggcggcga aggagaagtc cacgcctaca tgggggtaga gtcataatcg tgcatcagga 34080

tagggcggtg gtgctgcagc agcgcgcgaa taaactgctg ccgccgccgc tccgtcctgc 34140 aggaatacaa catggcagtg gtctcctcag cgatgattcg caccgcccgc agcataaggc 34200

gccttgtcct ccgggcacag cagcgcaccc tgatctcact taaatcagca cagtaactgc 34260

agcacagcac cacaatattg ttcaaaatcc cacagtgcaa ggcgctgtat ccaaagctca 34320 tggcggggac cacagaaccc acgtggccat cataccacaa gcgcaggtag attaagtggc 34380

gacccctcat aaacacgctg gacataaaca ttacctcttt tggcatgttg taattcacca 34440 cctcccggta ccatataaac ctctgattaa acatggcgcc atccaccacc atcctaaacc 34500 agctggccaa aacctgcccg ccggctatac actgcaggga accgggactg gaacaatgac 34560

agtggagagc ccaggactcg taaccatgga tcatcatgct cgtcatgata tcaatgttgg 34620 cacaacacag gcacacgtgc atacacttcc tcaggattac aagctcctcc cgcgttagaa 34680 ccatatccca gggaacaacc cattcctgaa tcagcgtaaa tcccacactg cagggaagac 34740

ctcgcacgta actcacgttg tgcattgtca aagtgttaca ttcgggcagc agcggatgat 34800 cctccagtat ggtagcgcgg gtttctgtct caaaaggagg tagacgatcc ctactgtacg 34860

gagtgcgccg agacaaccga gatcgtgttg gtcgtagtgt catgccaaat ggaacgccgg 34920 acgtagtcat atttcctgaa gcaaaaccag gtgcgggcgt gacaaacaga tctgcgtctc 34980 cggtctcgcc gcttagatcg ctctgtgtag tagttgtagt atatccactc tctcaaagca 35040

tccaggcgcc ccctggcttc gggttctatg taaactcctt catgcgccgc tgccctgata 35100 Page 145

Sequence_Listing.txt acatccacca ccgcagaata agccacaccc agccaaccta cacattcgtt ctgcgagtca 35160

cacacgggag gagcgggaag agctggaaga accatgtttt tttttttatt ccaaaagatt 35220 atccaaaacc tcaaaatgaa gatctattaa gtgaacgcgc tcccctccgg tggcgtggtc 35280

aaactctaca gccaaagaac agataatggc atttgtaaga tgttgcacaa tggcttccaa 35340 aaggcaaacg gccctcacgt ccaagtggac gtaaaggcta aacccttcag ggtgaatctc 35400 ctctataaac attccagcac cttcaaccat gcccaaataa ttctcatctc gccaccttct 35460

caatatatct ctaagcaaat cccgaatatt aagtccggcc attgtaaaaa tctgctccag 35520 agcgccctcc accttcagcc tcaagcagcg aatcatgatt gcaaaaattc aggttcctca 35580 cagacctgta taagattcaa aagcggaaca ttaacaaaaa taccgcgatc ccgtaggtcc 35640

cttcgcaggg ccagctgaac ataatcgtgc aggtctgcac ggaccagcgc ggccacttcc 35700 ccgccaggaa ccatgacaaa agaacccaca ctgattatga cacgcatact cggagctatg 35760 ctaaccagcg tagccccgat gtaagcttgt tgcatgggcg gcgatataaa atgcaaggtg 35820

ctgctcaaaa aatcaggcaa agcctcgcgc aaaaaagaaa gcacatcgta gtcatgctca 35880 tgcagataaa ggcaggtaag ctccggaacc accacagaaa aagacaccat ttttctctca 35940

aacatgtctg cgggtttctg cataaacaca aaataaaata acaaaaaaac atttaaacat 36000

tagaagcctg tcttacaaca ggaaaaacaa cccttataag cataagacgg actacggcca 36060

tgccggcgtg accgtaaaaa aactggtcac cgtgattaaa aagcaccacc gacagctcct 36120

cggtcatgtc cggagtcata atgtaagact cggtaaacac atcaggttga ttcacatcgg 36180 tcagtgctaa aaagcgaccg aaatagcccg ggggaataca tacccgcagg cgtagagaca 36240

acattacagc ccccatagga ggtataacaa aattaatagg agagaaaaac acataaacac 36300

ctgaaaaacc ctcctgccta ggcaaaatag caccctcccg ctccagaaca acatacagcg 36360 cttccacagc ggcagccata acagtcagcc ttaccagtaa aaaagaaaac ctattaaaaa 36420

aacaccactc gacacggcac cagctcaatc agtcacagtg taaaaaaggg ccaagtgcag 36480 agcgagtata tataggacta aaaaatgacg taacggttaa agtccacaaa aaacacccag 36540 aaaaccgcac gcgaacctac gcccagaaac gaaagccaaa aaacccacaa cttcctcaaa 36600

tcgtcacttc cgttttccca cgttacgtca cttcccattt taagaaaact acaattccca 36660 acacatacaa gttactccgc cctaaaacct acgtcacccg ccccgttccc acgccccgcg 36720 ccacgtcaca aactccaccc cctcattatc atattggctt caatccaaaa taaggtatat 36780

tattgatgat g 36791

<210> 9 <211> 36720 <212> DNA <213> Artificial Sequence <220> <223> Synthetic adenovirus genome E3-14.7k-P2A-YPet

Page 146

Sequence_Listing.txt <400> 9 catcatcaat aatatacctt attttggatt gaagccaata tgataatgag ggggtggagt 60

ttgtgacgtg gcgcggggcg tgggaacggg gcgggtgacg tagtagtgtg gcggaagtgt 120 gatgttgcaa gtgtggcgga acacatgtaa gcgacggatg tggcaaaagt gacgtttttg 180

gtgtgcgccg gtgtacacag gaagtgacaa ttttcgcgcg gttttaggcg gatgttgtag 240 taaatttggg cgtaaccgag taagatttgg ccattttcgc gggaaaactg aataagagga 300 agtgaaatct gaataatttt gtgttactca tagcgcgtaa tatttgtcta gggccgcggg 360

gactttgacc gtttacgtgg agactcgccc aggtgttttt ctcaggtgtt ttccgcgttc 420 cgggtcaaag ttggcgtttt attattatag tcagctgacg tgtagtgtat ttatacccgg 480 tgagttcctc aagaggccac tcttgagtgc cagcgagtag agttttctcc tccgagccgc 540

tccgacaccg ggactgaaaa tgagacatat tatctgccac ggaggtgtta ttaccgaaga 600 aatggccgcc agtcttttgg accagctgat cgaagaggta ctggctgata atcttccacc 660 tcctagccat tttgaaccac ctacccttca cgaactgtat gatttagacg tgacggcccc 720

cgaagatccc aacgaggagg cggtttcgca gatttttccc gactctgtaa tgttggcggt 780 gcaggaaggg attgacttac tcacttttcc gccggcgccc ggttctccgg agccgcctca 840

cctttcccgg cagcccgagc agccggagca gagagccttg ggtccggttt ctatgccaaa 900

ccttgtaccg gaggtgatcg atcttacctg ccacgaggct ggctttccac ccagtgacga 960

cgaggatgaa gagggtgagg agtttgtgtt agattatgtg gagcaccccg ggcacggttg 1020

caggtcttgt cattatcacc ggaggaatac gggggaccca gatattatgt gttcgctttg 1080 ctatatgagg acctgtggca tgtttgtcta cagtaagtga aaattatggg cagtgggtga 1140

tagagtggtg ggtttggtgt ggtaattttt tttttaattt ttacagtttt gtggtttaaa 1200

gaattttgta ttgtgatttt tttaaaaggt cctgtgtctg aacctgagcc tgagcccgag 1260 ccagaaccgg agcctgcaag acctacccgc cgtcctaaaa tggcgcctgc tatcctgaga 1320

cgcccgacat cacctgtgtc tagagaatgc aatagtagta cggatagctg tgactccggt 1380 ccttctaaca cacctcctga gatacacccg gtggtcccgc tgtgccccat taaaccagtt 1440 gccgtgagag ttggtgggcg tcgccaggct gtggaatgta tcgaggactt gcttaacgag 1500

cctgggcaac ctttggactt gagctgtaaa cgccccaggc cataaggtgt aaacctgtga 1560 ttgcgtgtgt ggttaacgcc tttgtttgct gaatgagttg atgtaagttt aataaagggt 1620 gagataatgt ttaacttgca tggcgtgtta aatggggcgg ggcttaaagg gtatataatg 1680

cgccgtgggc taatcttggt tacatctgac ctcatggagg cttgggagtg tttggaagat 1740 ttttctgctg tgcgtaactt gctggaacag agctctaaca gtacctcttg gttttggagg 1800

tttctgtggg gctcatccca ggcaaagtta gtctgcagaa ttaaggagga ttacaagtgg 1860 gaatttgaag agcttttgaa atcctgtggt gagctgtttg attctttgaa tctgggtcac 1920 caggcgcttt tccaagagaa ggtcatcaag actttggatt tttccacacc ggggcgcgct 1980

gcggctgctg ttgctttttt gagttttata aaggataaat ggagcgaaga aacccatctg 2040 Page 147

Sequence_Listing.txt agcggggggt acctgctgga ttttctggcc atgcatctgt ggagagcggt tgtgagacac 2100

aagaatcgcc tgctactgtt gtcttccgtc cgcccggcga taataccgac ggaggagcag 2160 cagcagcagc aggaggaagc caggcggcgg cggcaggagc agagcccatg gaacccgaga 2220

gccggcctgg accctcggga atgaatgttg tacaggtggc tgaactgtat ccagaactga 2280 gacgcatttt gacaattaca gaggatgggc aggggctaaa gggggtaaag agggagcggg 2340 gggcttgtga ggctacagag gaggctagga atctagcttt tagcttaatg accagacacc 2400

gtcctgagtg tattactttt caacagatca aggataattg cgctaatgag cttgatctgc 2460 tggcgcagaa gtattccata gagcagctga ccacttactg gctgcagcca ggggatgatt 2520 ttgaggaggc tattagggta tatgcaaagg tggcacttag gccagattgc aagtacaaga 2580

tcagcaaact tgtaaatatc aggaattgtt gctacatttc tgggaacggg gccgaggtgg 2640 agatagatac ggaggatagg gtggccttta gatgtagcat gataaatatg tggccggggg 2700 tgcttggcat ggacggggtg gttattatga atgtaaggtt tactggcccc aattttagcg 2760

gtacggtttt cctggccaat accaacctta tcctacacgg tgtaagcttc tatgggttta 2820 acaatacctg tgtggaagcc tggaccgatg taagggttcg gggctgtgcc ttttactgct 2880

gctggaaggg ggtggtgtgt cgccccaaaa gcagggcttc aattaagaaa tgcctctttg 2940

aaaggtgtac cttgggtatc ctgtctgagg gtaactccag ggtgcgccac aatgtggcct 3000

ccgactgtgg ttgcttcatg ctagtgaaaa gcgtggctgt gattaagcat aacatggtat 3060

gtggcaactg cgaggacagg gcctctcaga tgctgacctg ctcggacggc aactgtcacc 3120 tgctgaagac cattcacgta gccagccact ctcgcaaggc ctggccagtg tttgagcata 3180

acatactgac ccgctgttcc ttgcatttgg gtaacaggag gggggtgttc ctaccttacc 3240

aatgcaattt gagtcacact aagatattgc ttgagcccga gagcatgtcc aaggtgaacc 3300 tgaacggggt gtttgacatg accatgaaga tctggaaggt gctgaggtac gatgagaccc 3360

gcaccaggtg cagaccctgc gagtgtggcg gtaaacatat taggaaccag cctgtgatgc 3420 tggatgtgac cgaggagctg aggcccgatc acttggtgct ggcctgcacc cgcgctgagt 3480 ttggctctag cgatgaagat acagattgag gtactgaaat gtgtgggcgt ggcttaaggg 3540

tgggaaagaa tatataaggt gggggtctta tgtagttttg tatctgtttt gcagcagccg 3600 ccgccgccat gagcaccaac tcgtttgatg gaagcattgt gagctcatat ttgacaacgc 3660 gcatgccccc atgggccggg gtgcgtcaga atgtgatggg ctccagcatt gatggtcgcc 3720

ccgtcctgcc cgcaaactct actaccttga cctacgagac cgtgtctgga acgccgttgg 3780 agactgcagc ctccgccgcc gcttcagccg ctgcagccac cgcccgcggg attgtgactg 3840

actttgcttt cctgagcccg cttgcaagca gtgcagcttc ccgttcatcc gcccgcgatg 3900 acaagttgac ggctcttttg gcacaattgg attctttgac ccgggaactt aatgtcgttt 3960 ctcagcagct gttggatctg cgccagcagg tttctgccct gaaggcttcc tcccctccca 4020

atgcggttta aaacataaat aaaaaaccag actctgtttg gatttggatc aagcataagt 4080 Page 148

Sequence_Listing.txt gtcttgctgt ctttatttag gggttttgcg cgcgcggtag gcccgggacc agcggtctcg 4140

gtcgttgagg gtcctgtgta ttttttccag gacgtggtaa aggtgactct ggatgttcag 4200 atacatgggc ataagcccgt ctctggggtg gaggtagcac cactgcagag cttcatgctg 4260

cggggtggtg ttgtagatga tccagtcgta gcaggagcgc tgggcgtggt gcctaaaaat 4320 gtctttcagt agcaagctga ttgccagggg caggcccttg gtgtaagtgt ttacaaagcg 4380 gttaagctgg gatgggtgca tacgtgggga tatgagatgc atcttggact gtatttttag 4440

gttggctatg ttcccagcca tatccctccg gggattcatg ttgtgcagaa ccaccagcac 4500 agtgtatccg gtgcacttgg gaaatttgtc atgtagctta gaaggaaatg cgtggaagaa 4560 cttggagacg cccttgtgac ctccaagatt ttccatgcat tcgtccataa tgatggcaat 4620

gggcccacgg gcggcggcct gggcgaagat atttctggga tcactaacgt catagttgtg 4680 ttccaggatg agatcgtcat aggccatttt tacaaagcgc gggcggaggg tgccagactg 4740 cggtataatg gttccatccg gcccaggggc gtagttaccc tcacagattt gcatttccca 4800

cgctttgagt tcagatgggg ggatcatgtc tacctgcggg gcgatgaaga aaacggtttc 4860 cggggtaggg gagatcagct gggaagaaag caggttcctg agcagctgcg acttaccgca 4920

gccggtgggc ccgtaaatca cacctattac cggctgcaac tggtagttaa gagagctgca 4980

gctgccgtca tccctgagca ggggggccac ttcgttaagc atgtccctga ctcgcatgtt 5040

ttccctgacc aaatccgcca gaaggcgctc gccgcccagc gatagcagtt cttgcaagga 5100

agcaaagttt ttcaacggtt tgagaccgtc cgccgtaggc atgcttttga gcgtttgacc 5160 aagcagttcc aggcggtccc acagctcggt cacctgctct acggcatctc gatccagcat 5220

atctcctcgt ttcgcgggtt ggggcggctt tcgctgtacg gcagtagtcg gtgctcgtcc 5280

agacgggcca gggtcatgtc tttccacggg cgcagggtcc tcgtcagcgt agtctgggtc 5340 acggtgaagg ggtgcgctcc gggctgcgcg ctggccaggg tgcgcttgag gctggtcctg 5400

ctggtgctga agcgctgccg gtcttcgccc tgcgcgtcgg ccaggtagca tttgaccatg 5460 gtgtcatagt ccagcccctc cgcggcgtgg cccttggcgc gcagcttgcc cttggaggag 5520 gcgccgcacg aggggcagtg cagacttttg agggcgtaga gcttgggcgc gagaaatacc 5580

gattccgggg agtaggcatc cgcgccgcag gccccgcaga cggtctcgca ttccacgagc 5640 caggtgagct ctggccgttc ggggtcaaaa accaggtttc ccccatgctt tttgatgcgt 5700 ttcttacctc tggtttccat gagccggtgt ccacgctcgg tgacgaaaag gctgtccgtg 5760

tccccgtata cagacttgag aggcctgtcc tcgagcggtg ttccgcggtc ctcctcgtat 5820 agaaactcgg accactctga gacaaaggct cgcgtccagg ccagcacgaa ggaggctaag 5880

tgggaggggt agcggtcgtt gtccactagg gggtccactc gctccagggt gtgaagacac 5940 atgtcgccct cttcggcatc aaggaaggtg attggtttgt aggtgtaggc cacgtgaccg 6000 ggtgttcctg aaggggggct ataaaagggg gtgggggcgc gttcgtcctc actctcttcc 6060

gcatcgctgt ctgcgagggc cagctgttgg ggtgagtact ccctctgaaa agcgggcatg 6120 Page 149

Sequence_Listing.txt acttctgcgc taagattgtc agtttccaaa aacgaggagg atttgatatt cacctggccc 6180

gcggtgatgc ctttgagggt ggccgcatcc atctggtcag aaaagacaat ctttttgttg 6240 tcaagcttgg tggcaaacga cccgtagagg gcgttggaca gcaacttggc gatggagcgc 6300

agggtttggt ttttgtcgcg atcggcgcgc tccttggccg cgatgtttag ctgcacgtat 6360 tcgcgcgcaa cgcaccgcca ttcgggaaag acggtggtgc gctcgtcggg caccaggtgc 6420 acgcgccaac cgcggttgtg cagggtgaca aggtcaacgc tggtggctac ctctccgcgt 6480

aggcgctcgt tggtccagca gaggcggccg cccttgcgcg agcagaatgg cggtaggggg 6540 tctagctgcg tctcgtccgg ggggtctgcg tccacggtaa agaccccggg cagcaggcgc 6600 gcgtcgaagt agtctatctt gcatccttgc aagtctagcg cctgctgcca tgcgcgggcg 6660

gcaagcgcgc gctcgtatgg gttgagtggg ggaccccatg gcatggggtg ggtgagcgcg 6720 gaggcgtaca tgccgcaaat gtcgtaaacg tagaggggct ctctgagtat tccaagatat 6780 gtagggtagc atcttccacc gcggatgctg gcgcgcacgt aatcgtatag ttcgtgcgag 6840

ggagcgagga ggtcgggacc gaggttgcta cgggcgggct gctctgctcg gaagactatc 6900 tgcctgaaga tggcatgtga gttggatgat atggttggac gctggaagac gttgaagctg 6960

gcgtctgtga gacctaccgc gtcacgcacg aaggaggcgt aggagtcgcg cagcttgttg 7020

accagctcgg cggtgacctg cacgtctagg gcgcagtagt ccagggtttc cttgatgatg 7080

tcatacttat cctgtccctt ttttttccac agctcgcggt tgaggacaaa ctcttcgcgg 7140

tctttccagt actcttggat cggaaacccg tcggcctccg aacggtaaga gcctagcatg 7200 tagaactggt tgacggcctg gtaggcgcag catccctttt ctacgggtag cgcgtatgcc 7260

tgcgcggcct tccggagcga ggtgtgggtg agcgcaaagg tgtccctgac catgactttg 7320

aggtactggt atttgaagtc agtgtcgtcg catccgccct gctcccagag caaaaagtcc 7380 gtgcgctttt tggaacgcgg atttggcagg gcgaaggtga catcgttgaa gagtatcttt 7440

cccgcgcgag gcataaagtt gcgtgtgatg cggaagggtc ccggcacctc ggaacggttg 7500 ttaattacct gggcggcgag cacgatctcg tcaaagccgt tgatgttgtg gcccacaatg 7560 taaagttcca agaagcgcgg gatgcccttg atggaaggca attttttaag ttcctcgtag 7620

gtgagctctt caggggagct gagcccgtgc tctgaaaggg cccagtctgc aagatgaggg 7680 ttggaagcga cgaatgagct ccacaggtca cgggccatta gcatttgcag gtggtcgcga 7740 aaggtcctaa actggcgacc tatggccatt ttttctgggg tgatgcagta gaaggtaagc 7800

gggtcttgtt cccagcggtc ccatccaagg ttcgcggcta ggtctcgcgc ggcagtcact 7860 agaggctcat ctccgccgaa cttcatgacc agcatgaagg gcacgagctg cttcccaaag 7920

gcccccatcc aagtataggt ctctacatcg taggtgacaa agagacgctc ggtgcgagga 7980 tgcgagccga tcgggaagaa ctggatctcc cgccaccaat tggaggagtg gctattgatg 8040 tggtgaaagt agaagtccct gcgacgggcc gaacactcgt gctggctttt gtaaaaacgt 8100

gcgcagtact ggcagcggtg cacgggctgt acatcctgca cgaggttgac ctgacgaccg 8160 Page 150

Sequence_Listing.txt cgcacaagga agcagagtgg gaatttgagc ccctcgcctg gcgggtttgg ctggtggtct 8220

tctacttcgg ctgcttgtcc ttgaccgtct ggctgctcga ggggagttac ggtggatcgg 8280 accaccacgc cgcgcgagcc caaagtccag atgtccgcgc gcggcggtcg gagcttgatg 8340

acaacatcgc gcagatggga gctgtccatg gtctggagct cccgcggcgt caggtcaggc 8400 gggagctcct gcaggtttac ctcgcataga cgggtcaggg cgcgggctag atccaggtga 8460 tacctaattt ccaggggctg gttggtggcg gcgtcgatgg cttgcaagag gccgcatccc 8520

cgcggcgcga ctacggtacc gcgcggcggg cggtgggccg cgggggtgtc cttggatgat 8580 gcatctaaaa gcggtgacgc gggcgagccc ccggaggtag ggggggctcc ggacccgccg 8640 ggagaggggg caggggcacg tcggcgccgc gcgcgggcag gagctggtgc tgcgcgcgta 8700

ggttgctggc gaacgcgacg acgcggcggt tgatctcctg aatctggcgc ctctgcgtga 8760 agacgacggg cccggtgagc ttgaacctga aagagagttc gacagaatca atttcggtgt 8820 cgttgacggc ggcctggcgc aaaatctcct gcacgtctcc tgagttgtct tgataggcga 8880

tctcggccat gaactgctcg atctcttcct cctggagatc tccgcgtccg gctcgctcca 8940 cggtggcggc gaggtcgttg gaaatgcggg ccatgagctg cgagaaggcg ttgaggcctc 9000

cctcgttcca gacgcggctg tagaccacgc ccccttcggc atcgcgggcg cgcatgacca 9060

cctgcgcgag attgagctcc acgtgccggg cgaagacggc gtagtttcgc aggcgctgaa 9120

agaggtagtt gagggtggtg gcggtgtgtt ctgccacgaa gaagtacata acccagcgtc 9180

gcaacgtgga ttcgttgata tcccccaagg cctcaaggcg ctccatggcc tcgtagaagt 9240 ccacggcgaa gttgaaaaac tgggagttgc gcgccgacac ggttaactcc tcctccagaa 9300

gacggatgag ctcggcgaca gtgtcgcgca cctcgcgctc aaaggctaca ggggcctctt 9360

cttcttcttc aatctcctct tccataaggg cctccccttc ttcttcttct ggcggcggtg 9420 ggggaggggg gacacggcgg cgacgacggc gcaccgggag gcggtcgaca aagcgctcga 9480

tcatctcccc gcggcgacgg cgcatggtct cggtgacggc gcggccgttc tcgcgggggc 9540 gcagttggaa gacgccgccc gtcatgtccc ggttatgggt tggcgggggg ctgccatgcg 9600 gcagggatac ggcgctaacg atgcatctca acaattgttg tgtaggtact ccgccgccga 9660

gggacctgag cgagtccgca tcgaccggat cggaaaacct ctcgagaaag gcgtctaacc 9720 agtcacagtc gcaaggtagg ctgagcaccg tggcgggcgg cagcgggcgg cggtcggggt 9780 tgtttctggc ggaggtgctg ctgatgatgt aattaaagta ggcggtcttg agacggcgga 9840

tggtcgacag aagcaccatg tccttgggtc cggcctgctg aatgcgcagg cggtcggcca 9900 tgccccaggc ttcgttttga catcggcgca ggtctttgta gtagtcttgc atgagccttt 9960

ctaccggcac ttcttcttct ccttcctctt gtcctgcatc tcttgcatct atcgctgcgg 10020 cggcggcgga gtttggccgt aggtggcgcc ctcttcctcc catgcgtgtg accccgaagc 10080 ccctcatcgg ctgaagcagg gctaggtcgg cgacaacgcg ctcggctaat atggcctgct 10140

gcacctgcgt gagggtagac tggaagtcat ccatgtccac aaagcggtgg tatgcgcccg 10200 Page 151

Sequence_Listing.txt tgttgatggt gtaagtgcag ttggccataa cggaccagtt aacggtctgg tgacccggct 10260

gcgagagctc ggtgtacctg agacgcgagt aagccctcga gtcaaatacg tagtcgttgc 10320 aagtccgcac caggtactgg tatcccacca aaaagtgcgg cggcggctgg cggtagaggg 10380

gccagcgtag ggtggccggg gctccggggg cgagatcttc caacataagg cgatgatatc 10440 cgtagatgta cctggacatc caggtgatgc cggcggcggt ggtggaggcg cgcggaaagt 10500 cgcggacgcg gttccagatg ttgcgcagcg gcaaaaagtg ctccatggtc gggacgctct 10560

ggccggtcag gcgcgcgcaa tcgttgacgc tctagaccgt gcaaaaggag agcctgtaag 10620 cgggcactct tccgtggtct ggtggataaa ttcgcaaggg tatcatggcg gacgaccggg 10680 gttcgagccc cgtatccggc cgtccgccgt gatccatgcg gttaccgccc gcgtgtcgaa 10740

cccaggtgtg cgacgtcaga caacggggga gtgctccttt tggcttcctt ccaggcgcgg 10800 cggctgctgc gctagctttt ttggccactg gccgcgcgca gcgtaagcgg ttaggctgga 10860 aagcgaaagc attaagtggc tcgctccctg tagccggagg gttattttcc aagggttgag 10920

tcgcgggacc cccggttcga gtctcggacc ggccggactg cggcgaacgg gggtttgcct 10980 ccccgtcatg caagaccccg cttgcaaatt cctccggaaa cagggacgag cccctttttt 11040

gcttttccca gatgcatccg gtgctgcggc agatgcgccc ccctcctcag cagcggcaag 11100

agcaagagca gcggcagaca tgcagggcac cctcccctcc tcctaccgcg tcaggagggg 11160

cgacatccgc ggttgacgcg gcagcagatg gtgattacga acccccgcgg cgccgggccc 11220

ggcactacct ggacttggag gagggcgagg gcctggcgcg gctaggagcg ccctctcctg 11280 agcggcaccc aagggtgcag ctgaagcgtg atacgcgtga ggcgtacgtg ccgcggcaga 11340

acctgtttcg cgaccgcgag ggagaggagc ccgaggagat gcgggatcga aagttccacg 11400

cagggcgcga gctgcggcat ggcctgaatc gcgagcggtt gctgcgcgag gaggactttg 11460 agcccgacgc gcgaaccggg attagtcccg cgcgcgcaca cgtggcggcc gccgacctgg 11520

taaccgcata cgagcagacg gtgaaccagg agattaactt tcaaaaaagc tttaacaacc 11580 acgtgcgtac gcttgtggcg cgcgaggagg tggctatagg actgatgcat ctgtgggact 11640 ttgtaagcgc gctggagcaa aacccaaata gcaagccgct catggcgcag ctgttcctta 11700

tagtgcagca cagcagggac aacgaggcat tcagggatgc gctgctaaac atagtagagc 11760 ccgagggccg ctggctgctc gatttgataa acatcctgca gagcatagtg gtgcaggagc 11820 gcagcttgag cctggctgac aaggtggccg ccatcaacta ttccatgctt agcctgggca 11880

agttttacgc ccgcaagata taccataccc cttacgttcc catagacaag gaggtaaaga 11940 tcgaggggtt ctacatgcgc atggcgctga aggtgcttac cttgagcgac gacctgggcg 12000

tttatcgcaa cgagcgcatc cacaaggccg tgagcgtgag ccggcggcgc gagctcagcg 12060 accgcgagct gatgcacagc ctgcaaaggg ccctggctgg cacgggcagc ggcgatagag 12120 aggccgagtc ctactttgac gcgggcgctg acctgcgctg ggccccaagc cgacgcgccc 12180

tggaggcagc tggggccgga cctgggctgg cggtggcacc cgcgcgcgct ggcaacgtcg 12240 Page 152

Sequence_Listing.txt gcggcgtgga ggaatatgac gaggacgatg agtacgagcc agaggacggc gagtactaag 12300

cggtgatgtt tctgatcaga tgatgcaaga cgcaacggac ccggcggtgc gggcggcgct 12360 gcagagccag ccgtccggcc ttaactccac ggacgactgg cgccaggtca tggaccgcat 12420

catgtcgctg actgcgcgca atcctgacgc gttccggcag cagccgcagg ccaaccggct 12480 ctccgcaatt ctggaagcgg tggtcccggc gcgcgcaaac cccacgcacg agaaggtgct 12540 ggcgatcgta aacgcgctgg ccgaaaacag ggccatccgg cccgacgagg ccggcctggt 12600

ctacgacgcg ctgcttcagc gcgtggctcg ttacaacagc ggcaacgtgc agaccaacct 12660 ggaccggctg gtgggggatg tgcgcgaggc cgtggcgcag cgtgagcgcg cgcagcagca 12720 gggcaacctg ggctccatgg ttgcactaaa cgccttcctg agtacacagc ccgccaacgt 12780

gccgcgggga caggaggact acaccaactt tgtgagcgca ctgcggctaa tggtgactga 12840 gacaccgcaa agtgaggtgt accagtctgg gccagactat tttttccaga ccagtagaca 12900 aggcctgcag accgtaaacc tgagccaggc tttcaaaaac ttgcaggggc tgtggggggt 12960

gcgggctccc acaggcgacc gcgcgaccgt gtctagcttg ctgacgccca actcgcgcct 13020 gttgctgctg ctaatagcgc ccttcacgga cagtggcagc gtgtcccggg acacatacct 13080

aggtcacttg ctgacactgt accgcgaggc cataggtcag gcgcatgtgg acgagcatac 13140

tttccaggag attacaagtg tcagccgcgc gctggggcag gaggacacgg gcagcctgga 13200

ggcaacccta aactacctgc tgaccaaccg gcggcagaag atcccctcgt tgcacagttt 13260

aaacagcgag gaggagcgca ttttgcgcta cgtgcagcag agcgtgagcc ttaacctgat 13320 gcgcgacggg gtaacgccca gcgtggcgct ggacatgacc gcgcgcaaca tggaaccggg 13380

catgtatgcc tcaaaccggc cgtttatcaa ccgcctaatg gactacttgc atcgcgcggc 13440

cgccgtgaac cccgagtatt tcaccaatgc catcttgaac ccgcactggc taccgccccc 13500 tggtttctac accgggggat tcgaggtgcc cgagggtaac gatggattcc tctgggacga 13560

catagacgac agcgtgtttt ccccgcaacc gcagaccctg ctagagttgc aacagcgcga 13620 gcaggcagag gcggcgctgc gaaaggaaag cttccgcagg ccaagcagct tgtccgatct 13680 aggcgctgcg gccccgcggt cagatgctag tagcccattt ccaagcttga tagggtctct 13740

taccagcact cgcaccaccc gcccgcgcct gctgggcgag gaggagtacc taaacaactc 13800 gctgctgcag ccgcagcgcg aaaaaaacct gcctccggca tttcccaaca acgggataga 13860 gagcctagtg gacaagatga gtagatggaa gacgtacgcg caggagcaca gggacgtgcc 13920

aggcccgcgc ccgcccaccc gtcgtcaaag gcacgaccgt cagcggggtc tggtgtggga 13980 ggacgatgac tcggcagacg acagcagcgt cctggatttg ggagggagtg gcaacccgtt 14040

tgcgcacctt cgccccaggc tggggagaat gttttaaaaa aaaaaaaaaa gcatgatgca 14100 aaataaaaaa ctcaccaagg ccatggcacc gagcgttggt tttcttgtat tccccttagt 14160 atgcggcgcg cggcgatgta tgaggaaggt cctcctccct cctacgagag tgtggtgagc 14220

gcggcgccag tggcggcggc gctgggttct cccttcgatg ctcccctgga cccgccgttt 14280 Page 153

Sequence_Listing.txt gtgcctccgc ggtacctgcg gcctaccggg gggagaaaca gcatccgtta ctctgagttg 14340

gcacccctat tcgacaccac ccgtgtgtac ctggtggaca acaagtcaac ggatgtggca 14400 tccctgaact accagaacga ccacagcaac tttctgacca cggtcattca aaacaatgac 14460

tacagcccgg gggaggcaag cacacagacc atcaatcttg acgaccggtc gcactggggc 14520 ggcgacctga aaaccatcct gcataccaac atgccaaatg tgaacgagtt catgtttacc 14580 aataagttta aggcgcgggt gatggtgtcg cgcttgccta ctaaggacaa tcaggtggag 14640

ctgaaatacg agtgggtgga gttcacgctg cccgagggca actactccga gaccatgacc 14700 atagacctta tgaacaacgc gatcgtggag cactacttga aagtgggcag acagaacggg 14760 gttctggaaa gcgacatcgg ggtaaagttt gacacccgca acttcagact ggggtttgac 14820

cccgtcactg gtcttgtcat gcctggggta tatacaaacg aagccttcca tccagacatc 14880 attttgctgc caggatgcgg ggtggacttc acccacagcc gcctgagcaa cttgttgggc 14940 atccgcaagc ggcaaccctt ccaggagggc tttaggatca cctacgatga tctggagggt 15000

ggtaacattc ccgcactgtt ggatgtggac gcctaccagg cgagcttgaa agatgacacc 15060 gaacagggcg ggggtggcgc aggcggcagc aacagcagtg gcagcggcgc ggaagagaac 15120

tccaacgcgg cagccgcggc aatgcagccg gtggaggaca tgaacgatca tgccattcgc 15180

ggcgacacct ttgccacacg ggctgaggag aagcgcgctg aggccgaagc agcggccgaa 15240

gctgccgccc ccgctgcgca acccgaggtc gagaagcctc agaagaaacc ggtgatcaaa 15300

cccctgacag aggacagcaa gaaacgcagt tacaacctaa taagcaatga cagcaccttc 15360 acccagtacc gcagctggta ccttgcatac aactacggcg accctcagac cggaatccgc 15420

tcatggaccc tgctttgcac tcctgacgta acctgcggct cggagcaggt ctactggtcg 15480

ttgccagaca tgatgcaaga ccccgtgacc ttccgctcca cgcgccagat cagcaacttt 15540 ccggtggtgg gcgccgagct gttgcccgtg cactccaaga gcttctacaa cgaccaggcc 15600

gtctactccc aactcatccg ccagtttacc tctctgaccc acgtgttcaa tcgctttccc 15660 gagaaccaga ttttggcgcg cccgccagcc cccaccatca ccaccgtcag tgaaaacgtt 15720 cctgctctca cagatcacgg gacgctaccg ctgcgcaaca gcatcggagg agtccagcga 15780

gtgaccatta ctgacgccag acgccgcacc tgcccctacg tttacaaggc cctgggcata 15840 gtctcgccgc gcgtcctatc gagccgcact ttttgagcaa gcatgtccat ccttatatcg 15900 cccagcaata acacaggctg gggcctgcgc ttcccaagca agatgtttgg cggggccaag 15960

aagcgctccg accaacaccc agtgcgcgtg cgcgggcact accgcgcgcc ctggggcgcg 16020 cacaaacgcg gccgcactgg gcgcaccacc gtcgatgacg ccatcgacgc ggtggtggag 16080

gaggcgcgca actacacgcc cacgccgcca ccagtgtcca cagtggacgc ggccattcag 16140 accgtggtgc gcggagcccg gcgctatgct aaaatgaaga gacggcggag gcgcgtagca 16200 cgtcgccacc gccgccgacc cggcactgcc gcccaacgcg cggcggcggc cctgcttaac 16260

cgcgcacgtc gcaccggccg acgggcggcc atgcgggccg ctcgaaggct ggccgcgggt 16320 Page 154

Sequence_Listing.txt attgtcactg tgccccccag gtccaggcga cgagcggccg ccgcagcagc cgcggccatt 16380

agtgctatga ctcagggtcg caggggcaac gtgtattggg tgcgcgactc ggttagcggc 16440 ctgcgcgtgc ccgtgcgcac ccgccccccg cgcaactaga ttgcaagaaa aaactactta 16500

gactcgtact gttgtatgta tccagcggcg gcggcgcgca acgaagctat gtccaagcgc 16560 aaaatcaaag aagagatgct ccaggtcatc gcgccggaga tctatggccc cccgaagaag 16620 gaagagcagg attacaagcc ccgaaagcta aagcgggtca aaaagaaaaa gaaagatgat 16680

gatgatgaac ttgacgacga ggtggaactg ctgcacgcta ccgcgcccag gcgacgggta 16740 cagtggaaag gtcgacgcgt aaaacgtgtt ttgcgacccg gcaccaccgt agtctttacg 16800 cccggtgagc gctccacccg cacctacaag cgcgtgtatg atgaggtgta cggcgacgag 16860

gacctgcttg agcaggccaa cgagcgcctc ggggagtttg cctacggaaa gcggcataag 16920 gacatgctgg cgttgccgct ggacgagggc aacccaacac ctagcctaaa gcccgtaaca 16980 ctgcagcagg tgctgcccgc gcttgcaccg tccgaagaaa agcgcggcct aaagcgcgag 17040

tctggtgact tggcacccac cgtgcagctg atggtaccca agcgccagcg actggaagat 17100 gtcttggaaa aaatgaccgt ggaacctggg ctggagcccg aggtccgcgt gcggccaatc 17160

aagcaggtgg cgccgggact gggcgtgcag accgtggacg ttcagatacc cactaccagt 17220

agcaccagta ttgccaccgc cacagagggc atggagacac aaacgtcccc ggttgcctca 17280

gcggtggcgg atgccgcggt gcaggcggtc gctgcggccg cgtccaagac ctctacggag 17340

gtgcaaacgg acccgtggat gtttcgcgtt tcagcccccc ggcgcccgcg ccgttcgagg 17400 aagtacggcg ccgccagcgc gctactgccc gaatatgccc tacatccttc cattgcgcct 17460

acccccggct atcgtggcta cacctaccgc cccagaagac gagcaactac ccgacgccga 17520

accaccactg gaacccgccg ccgccgtcgc cgtcgccagc ccgtgctggc cccgatttcc 17580 gtgcgcaggg tggctcgcga aggaggcagg accctggtgc tgccaacagc gcgctaccac 17640

cccagcatcg tttaaaagcc ggtctttgtg gttcttgcag atatggccct cacctgccgc 17700 ctccgtttcc cggtgccggg attccgagga agaatgcacc gtaggagggg catggccggc 17760 cacggcctga cgggcggcat gcgtcgtgcg caccaccggc ggcggcgcgc gtcgcaccgt 17820

cgcatgcgcg gcggtatcct gcccctcctt attccactga tcgccgcggc gattggcgcc 17880 gtgcccggaa ttgcatccgt ggccttgcag gcgcagagac actgattaaa aacaagttgc 17940 atgtggaaaa atcaaaataa aaagtctgga ctctcacgct cgcttggtcc tgtaactatt 18000

ttgtagaatg gaagacatca actttgcgtc tctggccccg cgacacggct cgcgcccgtt 18060 catgggaaac tggcaagata tcggcaccag caatatgagc ggtggcgcct tcagctgggg 18120

ctcgctgtgg agcggcatta aaaatttcgg ttccaccgtt aagaactatg gcagcaaggc 18180 ctggaacagc agcacaggcc agatgctgag ggataagttg aaagagcaaa atttccaaca 18240 aaaggtggta gatggcctgg cctctggcat tagcggggtg gtggacctgg ccaaccaggc 18300

agtgcaaaat aagattaaca gtaagcttga tccccgccct cccgtagagg agcctccacc 18360 Page 155

Sequence_Listing.txt ggccgtggag acagtgtctc cagaggggcg tggcgaaaag cgtccgcgcc ccgacaggga 18420

agaaactctg gtgacgcaaa tagacgagcc tccctcgtac gaggaggcac taaagcaagg 18480 cctgcccacc acccgtccca tcgcgcccat ggctaccgga gtgctgggcc agcacacacc 18540

cgtaacgctg gacctgcctc cccccgccga cacccagcag aaacctgtgc tgccaggccc 18600 gaccgccgtt gttgtaaccc gtcctagccg cgcgtccctg cgccgcgccg ccagcggtcc 18660 gcgatcgttg cggcccgtag ccagtggcaa ctggcaaagc acactgaaca gcatcgtggg 18720

tctgggggtg caatccctga agcgccgacg atgcttctga tagctaacgt gtcgtatgtg 18780 tgtcatgtat gcgtccatgt cgccgccaga ggagctgctg agccgccgcg cgcccgcttt 18840 ccaagatggc taccccttcg atgatgccgc agtggtctta catgcacatc tcgggccagg 18900

acgcctcgga gtacctgagc cccgggctgg tgcagtttgc ccgcgccacc gagacgtact 18960 tcagcctgaa taacaagttt agaaacccca cggtggcgcc tacgcacgac gtgaccacag 19020 accggtccca gcgtttgacg ctgcggttca tccctgtgga ccgtgaggat actgcgtact 19080

cgtacaaggc gcggttcacc ctagctgtgg gtgataaccg tgtgctggac atggcttcca 19140 cgtactttga catccgcggc gtgctggaca ggggccctac ttttaagccc tactctggca 19200

ctgcctacaa cgccctggct cccaagggtg ccccaaatcc ttgcgaatgg gatgaagctg 19260

ctactgctct tgaaataaac ctagaagaag aggacgatga caacgaagac gaagtagacg 19320

agcaagctga gcagcaaaaa actcacgtat ttgggcaggc gccttattct ggtataaata 19380

ttacaaagga gggtattcaa ataggtgtcg aaggtcaaac acctaaatat gccgataaaa 19440 catttcaacc tgaacctcaa ataggagaat ctcagtggta cgaaacagaa attaatcatg 19500

cagctgggag agtcctaaaa aagactaccc caatgaaacc atgttacggt tcatatgcaa 19560

aacccacaaa tgaaaatgga gggcaaggca ttcttgtaaa gcaacaaaat ggaaagctag 19620 aaagtcaagt ggaaatgcaa tttttctcaa ctactgaggc agccgcaggc aatggtgata 19680

acttgactcc taaagtggta ttgtacagtg aagatgtaga tatagaaacc ccagacactc 19740 atatttctta catgcccact attaaggaag gtaactcacg agaactaatg ggccaacaat 19800 ctatgcccaa caggcctaat tacattgctt ttagggacaa ttttattggt ctaatgtatt 19860

acaacagcac gggtaatatg ggtgttctgg cgggccaagc atcgcagttg aatgctgttg 19920 tagatttgca agacagaaac acagagcttt cataccagct tttgcttgat tccattggtg 19980 atagaaccag gtacttttct atgtggaatc aggctgttga cagctatgat ccagatgtta 20040

gaattattga aaatcatgga actgaagatg aacttccaaa ttactgcttt ccactgggag 20100 gtgtgattaa tacagagact cttaccaagg taaaacctaa aacaggtcag gaaaatggat 20160

gggaaaaaga tgctacagaa ttttcagata aaaatgaaat aagagttgga aataattttg 20220 ccatggaaat caatctaaat gccaacctgt ggagaaattt cctgtactcc aacatagcgc 20280 tgtatttgcc cgacaagcta aagtacagtc cttccaacgt aaaaatttct gataacccaa 20340

acacctacga ctacatgaac aagcgagtgg tggctcccgg gctagtggac tgctacatta 20400 Page 156

Sequence_Listing.txt accttggagc acgctggtcc cttgactata tggacaacgt caacccattt aaccaccacc 20460

gcaatgctgg cctgcgctac cgctcaatgt tgctgggcaa tggtcgctat gtgcccttcc 20520 acatccaggt gcctcagaag ttctttgcca ttaaaaacct ccttctcctg ccgggctcat 20580

acacctacga gtggaacttc aggaaggatg ttaacatggt tctgcagagc tccctaggaa 20640 atgacctaag ggttgacgga gccagcatta agtttgatag catttgcctt tacgccacct 20700 tcttccccat ggcccacaac accgcctcca cgcttgaggc catgcttaga aacgacacca 20760

acgaccagtc ctttaacgac tatctctccg ccgccaacat gctctaccct atacccgcca 20820 acgctaccaa cgtgcccata tccatcccct cccgcaactg ggcggctttc cgcggctggg 20880 ccttcacgcg ccttaagact aaggaaaccc catcactggg ctcgggctac gacccttatt 20940

acacctactc tggctctata ccctacctag atggaacctt ttacctcaac cacaccttta 21000 agaaggtggc cattaccttt gactcttctg tcagctggcc tggcaatgac cgcctgctta 21060 cccccaacga gtttgaaatt aagcgctcag ttgacgggga gggttacaac gttgcccagt 21120

gtaacatgac caaagactgg ttcctggtac aaatgctagc taactataac attggctacc 21180 agggcttcta tatcccagag agctacaagg accgcatgta ctccttcttt agaaacttcc 21240

agcccatgag ccgtcaggtg gtggatgata ctaaatacaa ggactaccaa caggtgggca 21300

tcctacacca acacaacaac tctggatttg ttggctacct tgcccccacc atgcgcgaag 21360

gacaggccta ccctgctaac ttcccctatc cgcttatagg caagaccgca gttgacagca 21420

ttacccagaa aaagtttctt tgcgatcgca ccctttggcg catcccattc tccagtaact 21480 ttatgtccat gggcgcactc acagacctgg gccaaaacct tctctacgcc aactccgccc 21540

acgcgctaga catgactttt gaggtggatc ccatggacga gcccaccctt ctttatgttt 21600

tgtttgaagt ctttgacgtg gtccgtgtgc accagccgca ccgcggcgtc atcgaaaccg 21660 tgtacctgcg cacgcccttc tcggccggca acgccacaac ataaagaagc aagcaacatc 21720

aacaacagct gccgccatgg gctccagtga gcaggaactg aaagccattg tcaaagatct 21780 tggttgtggg ccatattttt tgggcaccta tgacaagcgc tttccaggct ttgtttctcc 21840 acacaagctc gcctgcgcca tagtcaatac ggccggtcgc gagactgggg gcgtacactg 21900

gatggccttt gcctggaacc cgcactcaaa aacatgctac ctctttgagc cctttggctt 21960 ttctgaccag cgactcaagc aggtttacca gtttgagtac gagtcactcc tgcgccgtag 22020 cgccattgct tcttcccccg accgctgtat aacgctggaa aagtccaccc aaagcgtaca 22080

ggggcccaac tcggccgcct gtggactatt ctgctgcatg tttctccacg cctttgccaa 22140 ctggccccaa actcccatgg atcacaaccc caccatgaac cttattaccg gggtacccaa 22200

ctccatgctc aacagtcccc aggtacagcc caccctgcgt cgcaaccagg aacagctcta 22260 cagcttcctg gagcgccact cgccctactt ccgcagccac agtgcgcaga ttaggagcgc 22320 cacttctttt tgtcacttga aaaacatgta aaaataatgt actagagaca ctttcaataa 22380

aggcaaatgc ttttatttgt acactctcgg gtgattattt acccccaccc ttgccgtctg 22440 Page 157

Sequence_Listing.txt cgccgtttaa aaatcaaagg ggttctgccg cgcatcgcta tgcgccactg gcagggacac 22500

gttgcgatac tggtgtttag tgctccactt aaactcaggc acaaccatcc gcggcagctc 22560 ggtgaagttt tcactccaca ggctgcgcac catcaccaac gcgtttagca ggtcgggcgc 22620

cgatatcttg aagtcgcagt tggggcctcc gccctgcgcg cgcgagttgc gatacacagg 22680 gttgcagcac tggaacacta tcagcgccgg gtggtgcacg ctggccagca cgctcttgtc 22740 ggagatcaga tccgcgtcca ggtcctccgc gttgctcagg gcgaacggag tcaactttgg 22800

tagctgcctt cccaaaaagg gcgcgtgccc aggctttgag ttgcactcgc accgtagtgg 22860 catcaaaagg tgaccgtgcc cggtctgggc gttaggatac agcgcctgca taaaagcctt 22920 gatctgctta aaagccacct gagcctttgc gccttcagag aagaacatgc cgcaagactt 22980

gccggaaaac tgattggccg gacaggccgc gtcgtgcacg cagcaccttg cgtcggtgtt 23040 ggagatctgc accacatttc ggccccaccg gttcttcacg atcttggcct tgctagactg 23100 ctccttcagc gcgcgctgcc cgttttcgct cgtcacatcc atttcaatca cgtgctcctt 23160

atttatcata atgcttccgt gtagacactt aagctcgcct tcgatctcag cgcagcggtg 23220 cagccacaac gcgcagcccg tgggctcgtg atgcttgtag gtcacctctg caaacgactg 23280

caggtacgcc tgcaggaatc gccccatcat cgtcacaaag gtcttgttgc tggtgaaggt 23340

cagctgcaac ccgcggtgct cctcgttcag ccaggtcttg catacggccg ccagagcttc 23400

cacttggtca ggcagtagtt tgaagttcgc ctttagatcg ttatccacgt ggtacttgtc 23460

catcagcgcg cgcgcagcct ccatgccctt ctcccacgca gacacgatcg gcacactcag 23520 cgggttcatc accgtaattt cactttccgc ttcgctgggc tcttcctctt cctcttgcgt 23580

ccgcatacca cgcgccactg ggtcgtcttc attcagccgc cgcactgtgc gcttacctcc 23640

tttgccatgc ttgattagca ccggtgggtt gctgaaaccc accatttgta gcgccacatc 23700 ttctctttct tcctcgctgt ccacgattac ctctggtgat ggcgggcgct cgggcttggg 23760

agaagggcgc ttctttttct tcttgggcgc aatggccaaa tccgccgccg aggtcgatgg 23820 ccgcgggctg ggtgtgcgcg gcaccagcgc gtcttgtgat gagtcttcct cgtcctcgga 23880 ctcgatacgc cgcctcatcc gcttttttgg gggcgcccgg ggaggcggcg gcgacgggga 23940

cggggacgac acgtcctcca tggttggggg acgtcgcgcc gcaccgcgtc cgcgctcggg 24000 ggtggtttcg cgctgctcct cttcccgact ggccatttcc ttctcctata ggcagaaaaa 24060 gatcatggag tcagtcgaga agaaggacag cctaaccgcc ccctctgagt tcgccaccac 24120

cgcctccacc gatgccgcca acgcgcctac caccttcccc gtcgaggcac ccccgcttga 24180 ggaggaggaa gtgattatcg agcaggaccc aggttttgta agcgaagacg acgaggaccg 24240

ctcagtacca acagaggata aaaagcaaga ccaggacaac gcagaggcaa acgaggaaca 24300 agtcgggcgg ggggacgaaa ggcatggcga ctacctagat gtgggagacg acgtgctgtt 24360 gaagcatctg cagcgccagt gcgccattat ctgcgacgcg ttgcaagagc gcagcgatgt 24420

gcccctcgcc atagcggatg tcagccttgc ctacgaacgc cacctattct caccgcgcgt 24480 Page 158

Sequence_Listing.txt accccccaaa cgccaagaaa acggcacatg cgagcccaac ccgcgcctca acttctaccc 24540

cgtatttgcc gtgccagagg tgcttgccac ctatcacatc tttttccaaa actgcaagat 24600 acccctatcc tgccgtgcca accgcagccg agcggacaag cagctggcct tgcggcaggg 24660

cgctgtcata cctgatatcg cctcgctcaa cgaagtgcca aaaatctttg agggtcttgg 24720 acgcgacgag aagcgcgcgg caaacgctct gcaacaggaa aacagcgaaa atgaaagtca 24780 ctctggagtg ttggtggaac tcgagggtga caacgcgcgc ctagccgtac taaaacgcag 24840

catcgaggtc acccactttg cctacccggc acttaaccta ccccccaagg tcatgagcac 24900 agtcatgagt gagctgatcg tgcgccgtgc gcagcccctg gagagggatg caaatttgca 24960 agaacaaaca gaggagggcc tacccgcagt tggcgacgag cagctagcgc gctggcttca 25020

aacgcgcgag cctgccgact tggaggagcg acgcaaacta atgatggccg cagtgctcgt 25080 taccgtggag cttgagtgca tgcagcggtt ctttgctgac ccggagatgc agcgcaagct 25140 agaggaaaca ttgcactaca cctttcgaca gggctacgta cgccaggcct gcaagatctc 25200

caacgtggag ctctgcaacc tggtctccta ccttggaatt ttgcacgaaa accgccttgg 25260 gcaaaacgtg cttcattcca cgctcaaggg cgaggcgcgc cgcgactacg tccgcgactg 25320

cgtttactta tttctatgct acacctggca gacggccatg ggcgtttggc agcagtgctt 25380

ggaggagtgc aacctcaagg agctgcagaa actgctaaag caaaacttga aggacctatg 25440

gacggccttc aacgagcgct ccgtggccgc gcacctggcg gacatcattt tccccgaacg 25500

cctgcttaaa accctgcaac agggtctgcc agacttcacc agtcaaagca tgttgcagaa 25560 ctttaggaac tttatcctag agcgctcagg aatcttgccc gccacctgct gtgcacttcc 25620

tagcgacttt gtgcccatta agtaccgcga atgccctccg ccgctttggg gccactgcta 25680

ccttctgcag ctagccaact accttgccta ccactctgac ataatggaag acgtgagcgg 25740 tgacggtcta ctggagtgtc actgtcgctg caacctatgc accccgcacc gctccctggt 25800

ttgcaattcg cagctgctta acgaaagtca aattatcggt acctttgagc tgcagggtcc 25860 ctcgcctgac gaaaagtccg cggctccggg gttgaaactc actccggggc tgtggacgtc 25920 ggcttacctt cgcaaatttg tacctgagga ctaccacgcc cacgagatta ggttctacga 25980

agaccaatcc cgcccgccta atgcggagct taccgcctgc gtcattaccc agggccacat 26040 tcttggccaa ttgcaagcca tcaacaaagc ccgccaagag tttctgctac gaaagggacg 26100 gggggtttac ttggaccccc agtccggcga ggagctcaac ccaatccccc cgccgccgca 26160

gccctatcag cagcagccgc gggcccttgc ttcccaggat ggcacccaaa aagaagctgc 26220 agctgccgcc gccacccacg gacgaggagg aatactggga cagtcaggca gaggaggttt 26280

tggacgagga ggaggaggac atgatggaag actgggagag cctagacgag gaagcttccg 26340 aggtcgaaga ggtgtcagac gaaacaccgt caccctcggt cgcattcccc tcgccggcgc 26400 cccagaaatc ggcaaccggt tccagcatgg ctacaacctc cgctcctcag gcgccgccgg 26460

cactgcccgt tcgccgaccc aaccgtagat gggacaccac tggaaccagg gccggtaagt 26520 Page 159

Sequence_Listing.txt ccaagcagcc gccgccgtta gcccaagagc aacaacagcg ccaaggctac cgctcatggc 26580

gcgggcacaa gaacgccata gttgcttgct tgcaagactg tgggggcaac atctccttcg 26640 cccgccgctt tcttctctac catcacggcg tggccttccc ccgtaacatc ctgcattact 26700

accgtcatct ctacagccca tactgcaccg gcggcagcgg cagcaacagc agcggccaca 26760 cagaagcaaa ggcgaccgga tagcaagact ctgacaaagc ccaagaaatc cacagcggcg 26820 gcagcagcag gaggaggagc gctgcgtctg gcgcccaacg aacccgtatc gacccgcgag 26880

cttagaaaca ggatttttcc cactctgtat gctatatttc aacagagcag gggccaagaa 26940 caagagctga aaataaaaaa caggtctctg cgatccctca cccgcagctg cctgtatcac 27000 aaaagcgaag atcagcttcg gcgcacgctg gaagacgcgg aggctctctt cagtaaatac 27060

tgcgcgctga ctcttaagga ctagtttcgc gccctttctc aaatttaagc gcgaaaacta 27120 cgtcatctcc agcggccaca cccggcgcca gcacctgtcg tcagcgccat ttatgagcaa 27180 ggaaattccc acgccctaca tgtggagtta ccagccacaa atgggacttg cggctggagc 27240

tgcccaagac tactcaaccc gaataaacta catgagcgcg ggaccccaca tgatatcccg 27300 ggtcaacgga atacgcgccc accgaaaccg aattctcctg gaacaggcgg ctattaccac 27360

cacacctcgt aataacctta atccccgtag ttggcccgct gccctggtgt accaggaaag 27420

tcccgctccc accactgtgg tacttcccag agacgcccag gccgaagttc agatgactaa 27480

ctcaggggcg cagcttgcgg gcggctttcg tcacagggtg cggtcgcccg ggcagggtat 27540

aactcacctg acaatcagag ggcgaggtat tcagctcaac gacgagtcgg tgagctcctc 27600 gcttggtctc cgtccggacg ggacatttca gatcggcggc gccggccgct cttcattcac 27660

gcctcgtcag gcaatcctaa ctctgcagac ctcgtcctct gagccgcgct ctggaggcat 27720

tggaactctg caatttattg aggagtttgt gccatcggtc tactttaacc ccttctcggg 27780 acctcccggc cactatccgg atcaatttat tcctaacttt gacgcggtaa aggactcggc 27840

ggacggctac gactgaatgt taagtggaga ggcagagcaa ctgcgcctga aacacctggt 27900 ccactgtcgc cgccacaagt gctttgcccg cgactccggt gagttttgct actttgaatt 27960 gcccgaggat catatcgagg gcccggcgca cggcgtccgg cttaccgccc agggagagct 28020

tgcccgtagc ctgattcggg agtttaccca gcgccccctg ctagttgagc gggacagggg 28080 accctgtgtt ctcactgtga tttgcaactg tcctaaccct ggattacatc aagatctttg 28140 ttgccatctc tgtgctgagt ataataaata cagaaattaa aatatactgg ggctcctatc 28200

gccatcctgt aaacgccacc gtcttcaccc gcccaagcaa accaaggcga accttacctg 28260 gtacttttaa catctctccc tctgtgattt acaacagttt caacccagac ggagtgagtc 28320

tacgagagaa cctctccgag ctcagctact ccatcagaaa aaacaccacc ctccttacct 28380 gccgggaacg tacgagtgcg tcaccggccg ctgcaccaca cctaccgcct gaccgtaaac 28440 cagacttttt ccggacagac ctcaataact ctgtttacca gaacaggagg tgagcttaga 28500

aaacccttag ggtattaggc caaaggcgca gctactgtgg ggtttatgaa caattcaagc 28560 Page 160

Sequence_Listing.txt aactctacgg gctattctaa ttcaggtttc tctagaatcg gggttggggt tattctctgt 28620

cttgtgattc tctttattct tatactaacg cttctctgcc taaggctcgc cgcctgctgt 28680 gtgcacattt gcatttattg tcagcttttt aaacgctggg gtcgccaccc aagatgatta 28740

ggtacataat cctaggttta ctcacccttg cgtcagccca cggtaccacc caaaaggtgg 28800 attttaagga gccagcctgt aatgttacat tcgcagctga agctaatgag tgcaccactc 28860 ttataaaatg caccacagaa catgaaaagc tgcttattcg ccacaaaaac aaaattggca 28920

agtatgctgt ttatgctatt tggcagccag gtgacactac agagtataat gttacagttt 28980 tccagggtaa aagtcataaa acttttatgt atacttttcc attttatgaa atgtgcgaca 29040 ttaccatgta catgagcaaa cagtataagt tgtggccccc acaaaattgt gtggaaaaca 29100

ctggcacttt ctgctgcact gctatgctaa ttacagtgct cgctttggtc tgtaccctac 29160 tctatattaa atacaaaagc agacgcagct ttattgagga aaagaaaatg ccttaattta 29220 ctaagttaca aagctaatgt caccactaac tgctttactc gctgcttgca aaacaaattc 29280

aaaaagttag cattataatt agaataggat ttaaaccccc cggtcatttc ctgctcaata 29340 ccattcccct gaacaattga ctctatgtgg gatatgctcc agcgctacaa ccttgaagtc 29400

aggcttcctg gatgtcagca tctgactttg gccagcacct gtcccgcgga tttgttccag 29460

tccaactaca gcgacccacc ctaacagaga tgaccaacac aaccaacgcg gccgccgcta 29520

ccggacttac atctaccaca aatacacccc aagtttctgc ctttgtcaat aactgggata 29580

acttgggcat gtggtggttc tccatagcgc ttatgtttgt atgccttatt attatgtggc 29640 tcatctgctg cctaaagcgc aaacgcgccc gaccacccat ctatagtccc atcattgtgc 29700

tacacccaaa caatgatgga atccatagat tggacggact gaaacacatg ttcttttctc 29760

ttacagtatg attaaatgag acatgattcc tcgagttttt atattactga cccttgttgc 29820 gcttttttgt gcgtgctcca cattggctgc ggtttctcac atcgaagtag actgcattcc 29880

agccttcaca gtctatttgc tttacggatt tgtcaccctc acgctcatct gcagcctcat 29940 cactgtggtc atcgccttta tccagtgcat tgactgggtc tgtgtgcgct ttgcatatct 30000 cagacaccat ccccagtaca gggacaggac tatagctgag cttcttagaa ttctttaatt 30060

atgaaattta ctgtgacttt tctgctgatt atttgcaccc tatctgcgtt ttgttccccg 30120 acctccaagc ctcaaagaca tatatcatgc agattcactc gtatatggaa tattccaagt 30180 tgctacaatg aaaaaagcga tctttccgaa gcctggttat atgcaatcat ctctgttatg 30240

gtgttctgca gtaccatctt agccctagct atatatccct accttgacat tggctggaac 30300 gcaatagatg ccatgaacca cccaactttc cccgcgcccg ctatgcttcc actgcaacaa 30360

gttgttgccg gcggctttgt cccagccaat cagcctcgcc caccttctcc cacccccact 30420 gaaatcagct actttaatct aacaggagga gatgactgac accctagatc tagaaatgga 30480 cggaattatt acagagcagc gcctgctaga aagacgcagg gcagcggccg agcaacagcg 30540

catgaatcaa gagctccaag acatggttaa cttgcaccag tgcaaaaggg gtatcttttg 30600 Page 161

Sequence_Listing.txt tctggtaaag caggccaaag tcacctacga cagtaatacc accggacacc gccttagcta 30660

caagttgcca accaagcgtc agaaattggt ggtcatggtg ggagaaaagc ccattaccat 30720 aactcagcac tcggtagaaa ccgaaggctg cattcactca ccttgtcaag gacctgagga 30780

tctctgcacc cttattaaga ccctgtgcgg tctcaaagat cttattccct ttaacggaag 30840 cggagctact aacttcagcc tgctgaagca ggctggtgac gtcgaggaga atcctggccc 30900 aatggtgagc aaaggcgaag agctgttcac cggcgtggtg cccatcctgg tggagctgga 30960

cggcgacgtg aacggccaca agttcagcgt gagcggcgag ggcgagggcg acgccaccta 31020 cggcaagctg accctgaagc tgctgtgcac caccggcaag ctgcccgtgc cctggcccac 31080 cctggtgacc accctgggct acggcgtgca gtgcttcgcc cggtaccccg accacatgaa 31140

gcagcacgac ttcttcaaga gcgccatgcc cgagggctac gtgcaggagc ggaccatctt 31200 cttcaaggac gacggcaact acaagacccg ggccgaggtg aagttcgagg gcgacaccct 31260 ggtgaaccgg atcgagctga agggcatcga cttcaaggag gacggcaaca tcctgggcca 31320

caagctggag tacaactaca acagccacaa cgtgtacatc accgccgaca agcagaagaa 31380 cggcatcaag gccaacttca agatccggca caacatcgag gacggcggcg tgcagctggc 31440

cgaccactac cagcagaaca cccccatcgg cgacggcccc gtgctgctgc ccgacaacca 31500

ctacctgagc taccagagcg ccctgttcaa ggaccccaac gagaagcggg accacatggt 31560

gctgctggag ttcctgaccg ccgccggcat caccgagggc atgaacgagc tctataagta 31620

ataaaaaaaa ataataaagc atcacttact taaaatcagt tagcaaattt ctgtccagtt 31680 tattcagcag cacctccttg ccctcctccc agctctggta ttgcagcttc ctcctggctg 31740

caaactttct ccacaatcta aatggaatgt cagtttcctc ctgttcctgt ccatccgcac 31800

ccactatctt catgttgttg cagatgaagc gcgcaagacc gtctgaagat accttcaacc 31860 ccgtgtatcc atatgacacg gaaaccggtc ctccaactgt gccttttctt actcctccct 31920

ttgtatcccc caatgggttt caagagagtc cccctggggt actctctttg cgcctatccg 31980 aacctctagt tacctccaat ggcatgcttg cgctcaaaat gggcaacggc ctctctctgg 32040 acgaggccgg caaccttacc tcccaaaatg taaccactgt gagcccacct ctcaaaaaaa 32100

ccaagtcaaa cataaacctg gaaatatctg cacccctcac agttacctca gaagccctaa 32160 ctgtggctgc cgccgcacct ctaatggtcg cgggcaacac actcaccatg caatcacagg 32220 ccccgctaac cgtgcacgac tccaaactta gcattgccac ccaaggaccc ctcacagtgt 32280

cagaaggaaa gctagccctg caaacatcag gccccctcac caccaccgat agcagtaccc 32340 ttactatcac tgcctcaccc cctctaacta ctgccactgg tagcttgggc attgacttga 32400

aagagcccat ttatacacaa aatggaaaac taggactaaa gtacggggct cctttgcatg 32460 taacagacga cctaaacact ttgaccgtag caactggtcc aggtgtgact attaataata 32520 cttccttgca aactaaagtt actggagcct tgggttttga ttcacaaggc aatatgcaac 32580

ttaatgtagc aggaggacta aggattgatt ctcaaaacag acgccttata cttgatgtta 32640 Page 162

Sequence_Listing.txt gttatccgtt tgatgctcaa aaccaactaa atctaagact aggacagggc cctcttttta 32700

taaactcagc ccacaacttg gatattaact acaacaaagg cctttacttg tttacagctt 32760 caaacaattc caaaaagctt gaggttaacc taagcactgc caaggggttg atgtttgacg 32820

ctacagccat agccattaat gcaggagatg ggcttgaatt tggttcacct aatgcaccaa 32880 acacaaatcc cctcaaaaca aaaattggcc atggcctaga atttgattca aacaaggcta 32940 tggttcctaa actaggaact ggccttagtt ttgacagcac aggtgccatt acagtaggaa 33000

acaaaaataa tgataagcta actttgtgga ccacaccagc tccatctcct aactgtagac 33060 taaatgcaga gaaagatgct aaactcactt tggtcttaac aaaatgtggc agtcaaatac 33120 ttgctacagt ttcagttttg gctgttaaag gcagtttggc tccaatatct ggaacagttc 33180

aaagtgctca tcttattata agatttgacg aaaatggagt gctactaaac aattccttcc 33240 tggacccaga atattggaac tttagaaatg gagatcttac tgaaggcaca gcctatacaa 33300 acgctgttgg atttatgcct aacctatcag cttatccaaa atctcacggt aaaactgcca 33360

aaagtaacat tgtcagtcaa gtttacttaa acggagacaa aactaaacct gtaacactaa 33420 ccattacact aaacggtaca caggaaacag gagacacaac tccaagtgca tactctatgt 33480

cattttcatg ggactggtct ggccacaact acattaatga aatatttgcc acatcctctt 33540

acactttttc atacattgcc caagaataaa gaatcgtttg tgttatgttt caacgtgttt 33600

atttttcaat tgcagaaaat ttcgaatcat ttttcattca gtagtatagc cccaccacca 33660

catagcttat acagatcacc gtacctaaat caaactcaca gaaccctagt attcaacctg 33720 ccacctccct cccaacacac agagtacaca gtcctttctc cccggctggc cttaaaaagc 33780

atcatatcat gggtaacaga catattctta ggtgttatat tccacacggt ttcctgtcga 33840

gccaaacgct catcagtgat attaataaac tccccgggca gctcacttaa gttcatgtcg 33900 ctgtccagct gctgagccac aggctgctgt ccaacttgcg gttgcttaac gggcggcgaa 33960

ggagaagtcc acgcctacat gggggtagag tcataatcgt gcatcaggat agggcggtgg 34020 tgctgcagca gcgcgcgaat aaactgctgc cgccgccgct ccgtcctgca ggaatacaac 34080 atggcagtgg tctcctcagc gatgattcgc accgcccgca gcataaggcg ccttgtcctc 34140

cgggcacagc agcgcaccct gatctcactt aaatcagcac agtaactgca gcacagcacc 34200 acaatattgt tcaaaatccc acagtgcaag gcgctgtatc caaagctcat ggcggggacc 34260 acagaaccca cgtggccatc ataccacaag cgcaggtaga ttaagtggcg acccctcata 34320

aacacgctgg acataaacat tacctctttt ggcatgttgt aattcaccac ctcccggtac 34380 catataaacc tctgattaaa catggcgcca tccaccacca tcctaaacca gctggccaaa 34440

acctgcccgc cggctataca ctgcagggaa ccgggactgg aacaatgaca gtggagagcc 34500 caggactcgt aaccatggat catcatgctc gtcatgatat caatgttggc acaacacagg 34560 cacacgtgca tacacttcct caggattaca agctcctccc gcgttagaac catatcccag 34620

ggaacaaccc attcctgaat cagcgtaaat cccacactgc agggaagacc tcgcacgtaa 34680 Page 163

Sequence_Listing.txt ctcacgttgt gcattgtcaa agtgttacat tcgggcagca gcggatgatc ctccagtatg 34740

gtagcgcggg tttctgtctc aaaaggaggt agacgatccc tactgtacgg agtgcgccga 34800 gacaaccgag atcgtgttgg tcgtagtgtc atgccaaatg gaacgccgga cgtagtcata 34860

tttcctgaag caaaaccagg tgcgggcgtg acaaacagat ctgcgtctcc ggtctcgccg 34920 cttagatcgc tctgtgtagt agttgtagta tatccactct ctcaaagcat ccaggcgccc 34980 cctggcttcg ggttctatgt aaactccttc atgcgccgct gccctgataa catccaccac 35040

cgcagaataa gccacaccca gccaacctac acattcgttc tgcgagtcac acacgggagg 35100 agcgggaaga gctggaagaa ccatgttttt ttttttattc caaaagatta tccaaaacct 35160 caaaatgaag atctattaag tgaacgcgct cccctccggt ggcgtggtca aactctacag 35220

ccaaagaaca gataatggca tttgtaagat gttgcacaat ggcttccaaa aggcaaacgg 35280 ccctcacgtc caagtggacg taaaggctaa acccttcagg gtgaatctcc tctataaaca 35340 ttccagcacc ttcaaccatg cccaaataat tctcatctcg ccaccttctc aatatatctc 35400

taagcaaatc ccgaatatta agtccggcca ttgtaaaaat ctgctccaga gcgccctcca 35460 ccttcagcct caagcagcga atcatgattg caaaaattca ggttcctcac agacctgtat 35520

aagattcaaa agcggaacat taacaaaaat accgcgatcc cgtaggtccc ttcgcagggc 35580

cagctgaaca taatcgtgca ggtctgcacg gaccagcgcg gccacttccc cgccaggaac 35640

catgacaaaa gaacccacac tgattatgac acgcatactc ggagctatgc taaccagcgt 35700

agccccgatg taagcttgtt gcatgggcgg cgatataaaa tgcaaggtgc tgctcaaaaa 35760 atcaggcaaa gcctcgcgca aaaaagaaag cacatcgtag tcatgctcat gcagataaag 35820

gcaggtaagc tccggaacca ccacagaaaa agacaccatt tttctctcaa acatgtctgc 35880

gggtttctgc ataaacacaa aataaaataa caaaaaaaca tttaaacatt agaagcctgt 35940 cttacaacag gaaaaacaac ccttataagc ataagacgga ctacggccat gccggcgtga 36000

ccgtaaaaaa actggtcacc gtgattaaaa agcaccaccg acagctcctc ggtcatgtcc 36060 ggagtcataa tgtaagactc ggtaaacaca tcaggttgat tcacatcggt cagtgctaaa 36120 aagcgaccga aatagcccgg gggaatacat acccgcaggc gtagagacaa cattacagcc 36180

cccataggag gtataacaaa attaatagga gagaaaaaca cataaacacc tgaaaaaccc 36240 tcctgcctag gcaaaatagc accctcccgc tccagaacaa catacagcgc ttccacagcg 36300 gcagccataa cagtcagcct taccagtaaa aaagaaaacc tattaaaaaa acaccactcg 36360

acacggcacc agctcaatca gtcacagtgt aaaaaagggc caagtgcaga gcgagtatat 36420 ataggactaa aaaatgacgt aacggttaaa gtccacaaaa aacacccaga aaaccgcacg 36480

cgaacctacg cccagaaacg aaagccaaaa aacccacaac ttcctcaaat cgtcacttcc 36540 gttttcccac gttacgtcac ttcccatttt aagaaaacta caattcccaa cacatacaag 36600 ttactccgcc ctaaaaccta cgtcacccgc cccgttccca cgccccgcgc cacgtcacaa 36660

actccacccc ctcattatca tattggcttc aatccaaaat aaggtatatt attgatgatg 36720 Page 164

Sequence_Listing.txt

<210> 10 <211> 36790 <212> DNA <213> Artificial Sequence

<220> <223> Synthetic adenovirus genome YPet-P2A-E4-ORF2 <400> 10 catcatcaat aatatacctt attttggatt gaagccaata tgataatgag ggggtggagt 60

ttgtgacgtg gcgcggggcg tgggaacggg gcgggtgacg tagtagtgtg gcggaagtgt 120 gatgttgcaa gtgtggcgga acacatgtaa gcgacggatg tggcaaaagt gacgtttttg 180 gtgtgcgccg gtgtacacag gaagtgacaa ttttcgcgcg gttttaggcg gatgttgtag 240

taaatttggg cgtaaccgag taagatttgg ccattttcgc gggaaaactg aataagagga 300 agtgaaatct gaataatttt gtgttactca tagcgcgtaa tatttgtcta gggccgcggg 360 gactttgacc gtttacgtgg agactcgccc aggtgttttt ctcaggtgtt ttccgcgttc 420

cgggtcaaag ttggcgtttt attattatag tcagctgacg tgtagtgtat ttatacccgg 480 tgagttcctc aagaggccac tcttgagtgc cagcgagtag agttttctcc tccgagccgc 540

tccgacaccg ggactgaaaa tgagacatat tatctgccac ggaggtgtta ttaccgaaga 600

aatggccgcc agtcttttgg accagctgat cgaagaggta ctggctgata atcttccacc 660

tcctagccat tttgaaccac ctacccttca cgaactgtat gatttagacg tgacggcccc 720

cgaagatccc aacgaggagg cggtttcgca gatttttccc gactctgtaa tgttggcggt 780 gcaggaaggg attgacttac tcacttttcc gccggcgccc ggttctccgg agccgcctca 840

cctttcccgg cagcccgagc agccggagca gagagccttg ggtccggttt ctatgccaaa 900

ccttgtaccg gaggtgatcg atcttacctg ccacgaggct ggctttccac ccagtgacga 960 cgaggatgaa gagggtgagg agtttgtgtt agattatgtg gagcaccccg ggcacggttg 1020

caggtcttgt cattatcacc ggaggaatac gggggaccca gatattatgt gttcgctttg 1080 ctatatgagg acctgtggca tgtttgtcta cagtaagtga aaattatggg cagtgggtga 1140 tagagtggtg ggtttggtgt ggtaattttt tttttaattt ttacagtttt gtggtttaaa 1200

gaattttgta ttgtgatttt tttaaaaggt cctgtgtctg aacctgagcc tgagcccgag 1260 ccagaaccgg agcctgcaag acctacccgc cgtcctaaaa tggcgcctgc tatcctgaga 1320 cgcccgacat cacctgtgtc tagagaatgc aatagtagta cggatagctg tgactccggt 1380

ccttctaaca cacctcctga gatacacccg gtggtcccgc tgtgccccat taaaccagtt 1440 gccgtgagag ttggtgggcg tcgccaggct gtggaatgta tcgaggactt gcttaacgag 1500

cctgggcaac ctttggactt gagctgtaaa cgccccaggc cataaggtgt aaacctgtga 1560 ttgcgtgtgt ggttaacgcc tttgtttgct gaatgagttg atgtaagttt aataaagggt 1620 gagataatgt ttaacttgca tggcgtgtta aatggggcgg ggcttaaagg gtatataatg 1680

cgccgtgggc taatcttggt tacatctgac ctcatggagg cttgggagtg tttggaagat 1740 Page 165

Sequence_Listing.txt ttttctgctg tgcgtaactt gctggaacag agctctaaca gtacctcttg gttttggagg 1800

tttctgtggg gctcatccca ggcaaagtta gtctgcagaa ttaaggagga ttacaagtgg 1860 gaatttgaag agcttttgaa atcctgtggt gagctgtttg attctttgaa tctgggtcac 1920

caggcgcttt tccaagagaa ggtcatcaag actttggatt tttccacacc ggggcgcgct 1980 gcggctgctg ttgctttttt gagttttata aaggataaat ggagcgaaga aacccatctg 2040 agcggggggt acctgctgga ttttctggcc atgcatctgt ggagagcggt tgtgagacac 2100

aagaatcgcc tgctactgtt gtcttccgtc cgcccggcga taataccgac ggaggagcag 2160 cagcagcagc aggaggaagc caggcggcgg cggcaggagc agagcccatg gaacccgaga 2220 gccggcctgg accctcggga atgaatgttg tacaggtggc tgaactgtat ccagaactga 2280

gacgcatttt gacaattaca gaggatgggc aggggctaaa gggggtaaag agggagcggg 2340 gggcttgtga ggctacagag gaggctagga atctagcttt tagcttaatg accagacacc 2400 gtcctgagtg tattactttt caacagatca aggataattg cgctaatgag cttgatctgc 2460

tggcgcagaa gtattccata gagcagctga ccacttactg gctgcagcca ggggatgatt 2520 ttgaggaggc tattagggta tatgcaaagg tggcacttag gccagattgc aagtacaaga 2580

tcagcaaact tgtaaatatc aggaattgtt gctacatttc tgggaacggg gccgaggtgg 2640

agatagatac ggaggatagg gtggccttta gatgtagcat gataaatatg tggccggggg 2700

tgcttggcat ggacggggtg gttattatga atgtaaggtt tactggcccc aattttagcg 2760

gtacggtttt cctggccaat accaacctta tcctacacgg tgtaagcttc tatgggttta 2820 acaatacctg tgtggaagcc tggaccgatg taagggttcg gggctgtgcc ttttactgct 2880

gctggaaggg ggtggtgtgt cgccccaaaa gcagggcttc aattaagaaa tgcctctttg 2940

aaaggtgtac cttgggtatc ctgtctgagg gtaactccag ggtgcgccac aatgtggcct 3000 ccgactgtgg ttgcttcatg ctagtgaaaa gcgtggctgt gattaagcat aacatggtat 3060

gtggcaactg cgaggacagg gcctctcaga tgctgacctg ctcggacggc aactgtcacc 3120 tgctgaagac cattcacgta gccagccact ctcgcaaggc ctggccagtg tttgagcata 3180 acatactgac ccgctgttcc ttgcatttgg gtaacaggag gggggtgttc ctaccttacc 3240

aatgcaattt gagtcacact aagatattgc ttgagcccga gagcatgtcc aaggtgaacc 3300 tgaacggggt gtttgacatg accatgaaga tctggaaggt gctgaggtac gatgagaccc 3360 gcaccaggtg cagaccctgc gagtgtggcg gtaaacatat taggaaccag cctgtgatgc 3420

tggatgtgac cgaggagctg aggcccgatc acttggtgct ggcctgcacc cgcgctgagt 3480 ttggctctag cgatgaagat acagattgag gtactgaaat gtgtgggcgt ggcttaaggg 3540

tgggaaagaa tatataaggt gggggtctta tgtagttttg tatctgtttt gcagcagccg 3600 ccgccgccca acttttctat acaaagttgt aatgagcacc aactcgtttg atggaagcat 3660 tgtgagctca tatttgacaa cgcgcatgcc cccatgggcc ggggtgcgtc agaatgtgat 3720

gggctccagc attgatggtc gccccgtcct gcccgcaaac tctactacct tgacctacga 3780 Page 166

Sequence_Listing.txt gaccgtgtct ggaacgccgt tggagactgc agcctccgcc gccgcttcag ccgctgcagc 3840

caccgcccgc gggattgtga ctgactttgc tttcctgagc ccgcttgcaa gcagtgcagc 3900 ttcccgttca tccgcccgcg atgacaagtt gacggctctt ttggcacaat tggattcttt 3960

gacccgggaa cttaatgtcg tttctcagca gctgttggat ctgcgccagc aggtttctgc 4020 cctgaaggct tcctcccctc ccaatgcggt ttaaaacata aataaaaaac cagactctgt 4080 ttggatttgg atcaagcata agtgtcttgc tgtctttatt taggggtttt gcgcgcgcgg 4140

taggcccggg accagcggtc tcggtcgttg agggtcctgt gtattttttc caggacgtgg 4200 taaaggtgac tctggatgtt cagatacatg ggcataagcc cgtctctggg gtggaggtag 4260 caccactgca gagcttcatg ctgcggggtg gtgttgtaga tgatccagtc gtagcaggag 4320

cgctgggcgt ggtgcctaaa aatgtctttc agtagcaagc tgattgccag gggcaggccc 4380 ttggtgtaag tgtttacaaa gcggttaagc tgggatgggt gcatacgtgg ggatatgaga 4440 tgcatcttgg actgtatttt taggttggct atgttcccag ccatatccct ccggggattc 4500

atgttgtgca gaaccaccag cacagtgtat ccggtgcact tgggaaattt gtcatgtagc 4560 ttagaaggaa atgcgtggaa gaacttggag acgcccttgt gacctccaag attttccatg 4620

cattcgtcca taatgatggc aatgggccca cgggcggcgg cctgggcgaa gatatttctg 4680

ggatcactaa cgtcatagtt gtgttccagg atgagatcgt cataggccat ttttacaaag 4740

cgcgggcgga gggtgccaga ctgcggtata atggttccat ccggcccagg ggcgtagtta 4800

ccctcacaga tttgcatttc ccacgctttg agttcagatg gggggatcat gtctacctgc 4860 ggggcgatga agaaaacggt ttccggggta ggggagatca gctgggaaga aagcaggttc 4920

ctgagcagct gcgacttacc gcagccggtg ggcccgtaaa tcacacctat taccgggtgc 4980

aactggtagt taagagagct gcagctgccg tcatccctga gcaggggggc cacttcgtta 5040 agcatgtccc tgactcgcat gttttccctg accaaatccg ccagaaggcg ctcgccgccc 5100

agcgatagca gttcttgcaa ggaagcaaag tttttcaacg gtttgagacc gtccgccgta 5160 ggcatgcttt tgagcgtttg accaagcagt tccaggcggt cccacagctc ggtcacctgc 5220 tctacggcat ctcgatccag catatctcct cgtttcgcgg gttggggcgg ctttcgctgt 5280

acggcagtag tcggtgctcg tccagacggg ccagggtcat gtctttccac gggcgcaggg 5340 tcctcgtcag cgtagtctgg gtcacggtga aggggtgcgc tccgggctgc gcgctggcca 5400 gggtgcgctt gaggctggtc ctgctggtgc tgaagcgctg ccggtcttcg ccctgcgcgt 5460

cggccaggta gcatttgacc atggtgtcat agtccagccc ctccgcggcg tggcccttgg 5520 cgcgcagctt gcccttggag gaggcgccgc acgaggggca gtgcagactt ttgagggcgt 5580

agagcttggg cgcgagaaat accgattccg gggagtaggc atccgcgccg caggccccgc 5640 agacggtctc gcattccacg agccaggtga gctctggccg ttcggggtca aaaaccaggt 5700 ttcccccatg ctttttgatg cgtttcttac ctctggtttc catgagccgg tgtccacgct 5760

cggtgacgaa aaggctgtcc gtgtccccgt atacagactt gagaggcctg tcctcgagcg 5820 Page 167

Sequence_Listing.txt gtgttccgcg gtcctcctcg tatagaaact cggaccactc tgagacaaag gctcgcgtcc 5880

aggccagcac gaaggaggct aagtgggagg ggtagcggtc gttgtccact agggggtcca 5940 ctcgctccag ggtgtgaaga cacatgtcgc cctcttcggc atcaaggaag gtgattggtt 6000

tgtaggtgta ggccacgtga ccgggtgttc ctgaaggggg gctataaaag ggggtggggg 6060 cgcgttcgtc ctcactctct tccgcatcgc tgtctgcgag ggccagctgt tggggtgagt 6120 actccctctg aaaagcgggc atgacttctg cgctaagatt gtcagtttcc aaaaacgagg 6180

aggatttgat attcacctgg cccgcggtga tgcctttgag ggtggccgca tccatctggt 6240 cagaaaagac aatctttttg ttgtcaagct tggtggcaaa cgacccgtag agggcgttgg 6300 acagcaactt ggcgatggag cgcagggttt ggtttttgtc gcgatcggcg cgctccttgg 6360

ccgcgatgtt tagctgcacg tattcgcgcg caacgcaccg ccattcggga aagacggtgg 6420 tgcgctcgtc gggcaccagg tgcacgcgcc aaccgcggtt gtgcagggtg acaaggtcaa 6480 cgctggtggc tacctctccg cgtaggcgct cgttggtcca gcagaggcgg ccgcccttgc 6540

gcgagcagaa tggcggtagg gggtctagct gcgtctcgtc cggggggtct gcgtccacgg 6600 taaagacccc gggcagcagg cgcgcgtcga agtagtctat cttgcatcct tgcaagtcta 6660

gcgcctgctg ccatgcgcgg gcggcaagcg cgcgctcgta tgggttgagt gggggacccc 6720

atggcatggg gtgggtgagc gcggaggcgt acatgccgca aatgtcgtaa acgtagaggg 6780

gctctctgag tattccaaga tatgtagggt agcatcttcc accgcggatg ctggcgcgca 6840

cgtaatcgta tagttcgtgc gagggagcga ggaggtcggg accgaggttg ctacgggcgg 6900 gctgctctgc tcggaagact atctgcctga agatggcatg tgagttggat gatatggttg 6960

gacgctggaa gacgttgaag ctggcgtctg tgagacctac cgcgtcacgc acgaaggagg 7020

cgtaggagtc gcgcagcttg ttgaccagct cggcggtgac ctgcacgtct agggcgcagt 7080 agtccagggt ttccttgatg atgtcatact tatcctgtcc cttttttttc cacagctcgc 7140

ggttgaggac aaactcttcg cggtctttcc agtactcttg gatcggaaac ccgtcggcct 7200 ccgaacggta agagcctagc atgtagaact ggttgacggc ctggtaggcg cagcatccct 7260 tttctacggg tagcgcgtat gcctgcgcgg ccttccggag cgaggtgtgg gtgagcgcaa 7320

aggtgtccct gaccatgact ttgaggtact ggtatttgaa gtcagtgtcg tcgcatccgc 7380 cctgctccca gagcaaaaag tccgtgcgct ttttggaacg cggatttggc agggcgaagg 7440 tgacatcgtt gaagagtatc tttcccgcgc gaggcataaa gttgcgtgtg atgcggaagg 7500

gtcccggcac ctcggaacgg ttgttaatta cctgggcggc gagcacgatc tcgtcaaagc 7560 cgttgatgtt gtggcccaca atgtaaagtt ccaagaagcg cgggatgccc ttgatggaag 7620

gcaatttttt aagttcctcg taggtgagct cttcagggga gctgagcccg tgctctgaaa 7680 gggcccagtc tgcaagatga gggttggaag cgacgaatga gctccacagg tcacgggcca 7740 ttagcatttg caggtggtcg cgaaaggtcc taaactggcg acctatggcc attttttctg 7800

gggtgatgca gtagaaggta agcgggtctt gttcccagcg gtcccatcca aggttcgcgg 7860 Page 168

Sequence_Listing.txt ctaggtctcg cgcggcagtc actagaggct catctccgcc gaacttcatg accagcatga 7920

agggcacgag ctgcttccca aaggccccca tccaagtata ggtctctaca tcgtaggtga 7980 caaagagacg ctcggtgcga ggatgcgagc cgatcgggaa gaactggatc tcccgccacc 8040

aattggagga gtggctattg atgtggtgaa agtagaagtc cctgcgacgg gccgaacact 8100 cgtgctggct tttgtaaaaa cgtgcgcagt actggcagcg gtgcacgggc tgtacatcct 8160 gcacgaggtt gacctgacga ccgcgcacaa ggaagcagag tgggaatttg agcccctcgc 8220

ctggcgggtt tggctggtgg tcttctactt cggctgcttg tccttgaccg tctggctgct 8280 cgaggggagt tacggtggat cggaccacca cgccgcgcga gcccaaagtc cagatgtccg 8340 cgcgcggcgg tcggagcttg atgacaacat cgcgcagatg ggagctgtcc atggtctgga 8400

gctcccgcgg cgtcaggtca ggcgggagct cctgcaggtt tacctcgcat agacgggtca 8460 gggcgcgggc tagatccagg tgatacctaa tttccagggg ctggttggtg gcggcgtcga 8520 tggcttgcaa gaggccgcat ccccgcggcg cgactacggt accgcgcggc gggcggtggg 8580

ccgcgggggt gtccttggat gatgcatcta aaagcggtga cgcgggcgag cccccggagg 8640 tagggggggc tccggacccg ccgggagagg gggcaggggc acgtcggcgc cgcgcgcggg 8700

caggagctgg tgctgcgcgc gtaggttgct ggcgaacgcg acgacgcggc ggttgatctc 8760

ctgaatctgg cgcctctgcg tgaagacgac gggcccggtg agcttgagcc tgaaagagag 8820

ttcgacagaa tcaatttcgg tgtcgttgac ggcggcctgg cgcaaaatct cctgcacgtc 8880

tcctgagttg tcttgatagg cgatctcggc catgaactgc tcgatctctt cctcctggag 8940 atctccgcgt ccggctcgct ccacggtggc ggcgaggtcg ttggaaatgc gggccatgag 9000

ctgcgagaag gcgttgaggc ctccctcgtt ccagacgcgg ctgtagacca cgcccccttc 9060

ggcatcgcgg gcgcgcatga ccacctgcgc gagattgagc tccacgtgcc gggcgaagac 9120 ggcgtagttt cgcaggcgct gaaagaggta gttgagggtg gtggcggtgt gttctgccac 9180

gaagaagtac ataacccagc gtcgcaacgt ggattcgttg atatccccca aggcctcaag 9240 gcgctccatg gcctcgtaga agtccacggc gaagttgaaa aactgggagt tgcgcgccga 9300 cacggttaac tcctcctcca gaagacggat gagctcggcg acagtgtcgc gcacctcgcg 9360

ctcaaaggct acaggggcct cttcttcttc ttcaatctcc tcttccataa gggcctcccc 9420 ttcttcttct tctggcggcg gtgggggagg ggggacacgg cggcgacgac ggcgcaccgg 9480 gaggcggtcg acaaagcgct cgatcatctc cccgcggcga cggcgcatgg tctcggtgac 9540

ggcgcggccg ttctcgcggg ggcgcagttg gaagacgccg cccgtcatgt cccggttatg 9600 ggttggcggg gggctgccat gcggcaggga tacggcgcta acgatgcatc tcaacaattg 9660

ttgtgtaggt actccgccgc cgagggacct gagcgagtcc gcatcgaccg gatcggaaaa 9720 cctctcgaga aaggcgtcta accagtcaca gtcgcaaggt aggctgagca ccgtggcggg 9780 cggcagcggg cggcggtcgg ggttgtttct ggcggaggtg ctgctgatga tgtaattaaa 9840

gtaggcggtc ttgagacggc ggatggtcga cagaagcacc atgtccttgg gtccggcctg 9900 Page 169

Sequence_Listing.txt ctgaatgcgc aggcggtcgg ccatgcccca ggcttcgttt tgacatcggc gcaggtcttt 9960

gtagtagtct tgcatgagcc tttctaccgg cacttcttct tctccttcct cttgtcctgc 10020 atctcttgca tctatcgctg cggcggcggc ggagtttggc cgtaggtggc gccctcttcc 10080

tcccatgcgt gtgaccccga agcccctcat cggctgaagc agggctaggt cggcgacaac 10140 gcgctcggct aatatggcct gctgcacctg cgtgagggta gactggaagt catccatgtc 10200 cacaaagcgg tggtatgcgc ccgtgttgat ggtgtaagtg cagttggcca taacggacca 10260

gttaacggtc tggtgacccg gctgcgagag ctcggtgtac ctgagacgcg agtaagccct 10320 cgagtcaaat acgtagtcgt tgcaagtccg caccaggtac tggtatccca ccaaaaagtg 10380 cggcggcggc tggcggtaga ggggccagcg tagggtggcc ggggctccgg gggcgagatc 10440

ttccaacata aggcgatgat atccgtagat gtacctggac atccaggtga tgccggcggc 10500 ggtggtggag gcgcgcggaa agtcgcggac gcggttccag atgttgcgca gcggcaaaaa 10560 gtgctccatg gtcgggacgc tctggccggt caggcgcgcg caatcgttga cgctctagac 10620

cgtgcaaaag gagagcctgt aagcgggcac tcttccgtgg tctggtggat aaattcgcaa 10680 gggtatcatg gcggacgacc ggggttcgag ccccgtatcc ggccgtccgc cgtgatccat 10740

gcggttaccg cccgcgtgtc gaacccaggt gtgcgacgtc agacaacggg ggagtgctcc 10800

ttttggcttc cttccaggcg cggcggctgc tgcgctagct tttttggcca ctggccgcgc 10860

gcagcgtaag cggttaggct ggaaagcgaa agcattaagt ggctcgctcc ctgtagccgg 10920

agggttattt tccaagggtt gagtcgcggg acccccggtt cgagtctcgg accggccgga 10980 ctgcggcgaa cgggggtttg cctccccgtc atgcaagacc ccgcttgcaa attcctccgg 11040

aaacagggac gagccccttt tttgcttttc ccagatgcat ccggtgctgc ggcagatgcg 11100

cccccctcct cagcagcggc aagagcaaga gcagcggcag acatgcaggg caccctcccc 11160 tcctcctacc gcgtcaggag gggcgacatc cgcggttgac gcggcagcag atggtgatta 11220

cgaacccccg cggcgccggg cccggcacta cctggacttg gaggagggcg agggcctggc 11280 gcggctagga gcgccctctc ctgagcggta cccaagggtg cagctgaagc gtgatacgcg 11340 tgaggcgtac gtgccgcggc agaacctgtt tcgcgaccgc gagggagagg agcccgagga 11400

gatgcgggat cgaaagttcc acgcagggcg cgagctgcgg catggcctga atcgcgagcg 11460 gttgctgcgc gaggaggact ttgagcccga cgcgcgaacc gggattagtc ccgcgcgcgc 11520 acacgtggcg gccgccgacc tggtaaccgc atacgagcag acggtgaacc aggagattaa 11580

ctttcaaaaa agctttaaca accacgtgcg tacgcttgtg gcgcgcgagg aggtggctat 11640 aggactgatg catctgtggg actttgtaag cgcgctggag caaaacccaa atagcaagcc 11700

gctcatggcg cagctgttcc ttatagtgca gcacagcagg gacaacgagg cattcaggga 11760 tgcgctgcta aacatagtag agcccgaggg ccgctggctg ctcgatttga taaacatcct 11820 gcagagcata gtggtgcagg agcgcagctt gagcctggct gacaaggtgg ccgccatcaa 11880

ctattccatg cttagcctgg gcaagtttta cgcccgcaag atataccata ccccttacgt 11940 Page 170

Sequence_Listing.txt tcccatagac aaggaggtaa agatcgaggg gttctacatg cgcatggcgc tgaaggtgct 12000

taccttgagc gacgacctgg gcgtttatcg caacgagcgc atccacaagg ccgtgagcgt 12060 gagccggcgg cgcgagctca gcgaccgcga gctgatgcac agcctgcaaa gggccctggc 12120

tggcacgggc agcggcgata gagaggccga gtcctacttt gacgcgggcg ctgacctgcg 12180 ctgggcccca agccgacgcg ccctggaggc agctggggcc ggacctgggc tggcggtggc 12240 acccgcgcgc gctggcaacg tcggcggcgt ggaggaatat gacgaggacg atgagtacga 12300

gccagaggac ggcgagtact aagcggtgat gtttctgatc agatgatgca agacgcaacg 12360 gacccggcgg tgcgggcggc gctgcagagc cagccgtccg gccttaactc cacggacgac 12420 tggcgccagg tcatggaccg catcatgtcg ctgactgcgc gcaatcctga cgcgttccgg 12480

cagcagccgc aggccaaccg gctctccgca attctggaag cggtggtccc ggcgcgcgca 12540 aaccccacgc acgagaaggt gctggcgatc gtaaacgcgc tggccgaaaa cagggccatc 12600 cggcccgacg aggccggcct ggtctacgac gcgctgcttc agcgcgtggc tcgttacaac 12660

agcggcaacg tgcagaccaa cctggaccgg ctggtggggg atgtgcgcga ggccgtggcg 12720 cagcgtgagc gcgcgcagca gcagggcaac ctgggctcca tggttgcact aaacgccttc 12780

ctgagtacac agcccgccaa cgtgccgcgg ggacaggagg actacaccaa ctttgtgagc 12840

gcactgcggc taatggtgac tgagacaccg caaagtgagg tgtaccagtc tgggccagac 12900

tattttttcc agaccagtag acaaggcctg cagaccgtaa acctgagcca ggctttcaaa 12960

aacttgcagg ggctgtgggg ggtgcgggct cccacaggcg accgcgcgac cgtgtctagc 13020 ttgctgacgc ccaactcgcg cctgttgctg ctgctaatag cgcccttcac ggacagtggc 13080

agcgtgtccc gggacacata cctaggtcac ttgctgacac tgtaccgcga ggccataggt 13140

caggcgcatg tggacgagca tactttccag gagattacaa gtgtcagccg cgcgctgggg 13200 caggaggaca cgggcagcct ggaggcaacc ctaaactacc tgctgaccaa ccggcggcag 13260

aagatcccct cgttgcacag tttaaacagc gaggaggagc gcattttgcg ctacgtgcag 13320 cagagcgtga gccttaacct gatgcgcgac ggggtaacgc ccagcgtggc gctggacatg 13380 accgcgcgca acatggaacc gggcatgtat gcctcaaacc ggccgtttat caaccgccta 13440

atggactact tgcatcgcgc ggccgccgtg aaccccgagt atttcaccaa tgccatcttg 13500 aacccgcact ggctaccgcc ccctggtttc tacaccgggg gattcgaggt gcccgagggt 13560 aacgatggat tcctctggga cgacatagac gacagcgtgt tttccccgca accgcagacc 13620

ctgctagagt tgcaacagcg cgagcaggca gaggcggcgc tgcgaaagga aagcttccgc 13680 aggccaagca gcttgtccga tctaggcgct gcggccccgc ggtcagatgc tagtagccca 13740

tttccaagct tgatagggtc tcttaccagc actcgcacca cccgcccgcg cctgctgggc 13800 gaggaggagt acctaaacaa ctcgctgctg cagccgcagc gcgaaaaaaa cctgcctccg 13860 gcatttccca acaacgggat agagagccta gtggacaaga tgagtagatg gaagacgtac 13920

gcgcaggagc acagggacgt gccaggcccg cgcccgccca cccgtcgtca aaggcacgac 13980 Page 171

Sequence_Listing.txt cgtcagcggg gtctggtgtg ggaggacgat gactcggcag acgacagcag cgtcctggat 14040

ttgggaggga gtggcaaccc gtttgcgcac cttcgcccca ggctggggag aatgttttaa 14100 aaaaaaaaaa gcatgatgca aaataaaaaa ctcaccaagg ccatggcacc gagcgttggt 14160

tttcttgtat tccccttagt atgcggcgcg cggcgatgta tgaggaaggt cctcctccct 14220 cctacgagag tgtggtgagc gcggcgccag tggcggcggc gctgggttct cccttcgatg 14280 ctcccctgga cccgccgttt gtgcctccgc ggtacctgcg gcctaccggg gggagaaaca 14340

gcatccgtta ctctgagttg gcacccctat tcgacaccac ccgtgtgtac ctggtggaca 14400 acaagtcaac ggatgtggca tccctgaact accagaacga ccacagcaac tttctgacca 14460 cggtcattca aaacaatgac tacagcccgg gggaggcaag cacacagacc atcaatcttg 14520

acgaccggtc gcactggggc ggcgacctga aaaccatcct gcataccaac atgccaaatg 14580 tgaacgagtt catgtttacc aataagttta aggcgcgggt gatggtgtcg cgcttgccta 14640 ctaaggacaa tcaggtggag ctgaaatacg agtgggtgga gttcacgctg cccgagggca 14700

actactccga gaccatgacc atagacctta tgaacaacgc gatcgtggag cactacttga 14760 aagtgggcag acagaacggg gttctggaaa gcgacatcgg ggtaaagttt gacacccgca 14820

acttcagact ggggtttgac cccgtcactg gtcttgtcat gcctggggta tatacaaacg 14880

aagccttcca tccagacatc attttgctgc caggatgcgg ggtggacttc acccacagcc 14940

gcctgagcaa cttgttgggc atccgcaagc ggcaaccctt ccaggagggc tttaggatca 15000

cctacgatga tctggagggt ggtaacattc ccgcactgtt ggatgtggac gcctaccagg 15060 cgagcttgaa agatgacacc gaacagggcg ggggtggcgc aggcggcagc aacagcagtg 15120

gcagcggcgc ggaagagaac tccaacgcgg cagccgcggc aatgcagccg gtggaggaca 15180

tgaacgatca tgccattcgc ggcgacacct ttgccacacg ggctgaggag aagcgcgctg 15240 aggccgaagc agcggccgaa gctgccgccc ccgctgcgca acccgaggtc gagaagcctc 15300

agaagaaacc ggtgatcaaa cccctgacag aggacagcaa gaaacgcagt tacaacctaa 15360 taagcaatga cagcaccttc acccagtacc gcagctggta ccttgcatac aactacggcg 15420 accctcagac cggaatccgc tcatggaccc tgctttgcac tcctgacgta acctgcggct 15480

cggagcaggt ctactggtcg ttgccagaca tgatgcaaga ccccgtgacc ttccgctcca 15540 cgcgccagat cagcaacttt ccggtggtgg gcgccgagct gttgcccgtg cactccaaga 15600 gcttctacaa cgaccaggcc gtctactccc aactcatccg ccagtttacc tctctgaccc 15660

acgtgttcaa tcgctttccc gagaaccaga ttttggcgcg cccgccagcc cccaccatca 15720 ccaccgtcag tgaaaacgtt cctgctctca cagatcacgg gacgctaccg ctgcgcaaca 15780

gcatcggagg agtccagcga gtgaccatta ctgacgccag acgccgcacc tgcccctacg 15840 tttacaaggc cctgggcata gtctcgccgc gcgtcctatc gagccgcact ttttgagcaa 15900 gcatgtccat ccttatatcg cccagcaata acacaggctg gggcctgcgc ttcccaagca 15960

agatgtttgg cggggccaag aagcgctccg accaacaccc agtgcgcgtg cgcgggcact 16020 Page 172

Sequence_Listing.txt accgcgcgcc ctggggcgcg cacaaacgcg gccgcactgg gcgcaccacc gtcgatgacg 16080

ccatcgacgc ggtggtggag gaggcgcgca actacacgcc cacgccgcca ccagtgtcca 16140 cagtggacgc ggccattcag accgtggtgc gcggagcccg gcgctatgct aaaatgaaga 16200

gacggcggag gcgcgtagca cgtcgccacc gccgccgacc cggcactgcc gcccaacgcg 16260 cggcggcggc cctgcttaac cgcgcacgtc gcaccggccg acgggcggcc atgcgggccg 16320 ctcgaaggct ggccgcgggt attgtcactg tgccccccag gtccaggcga cgagcggccg 16380

ccgcagcagc cgcggccatt agtgctatga ctcagggtcg caggggcaac gtgtattggg 16440 tgcgcgactc ggttagcggc ctgcgcgtgc ccgtgcgcac ccgccccccg cgcaactaga 16500 ttgcaagaaa aaactactta gactcgtact gttgtatgta tccagcggcg gcggcgcgca 16560

acgaagctat gtccaagcgc aaaatcaaag aagagatgct ccaggtcatc gcgccggaga 16620 tctatggccc cccgaagaag gaagagcagg attacaagcc ccgaaagcta aagcgggtca 16680 aaaagaaaaa gaaagatgat gatgatgaac ttgacgacga ggtggaactg ctgcacgcta 16740

ccgcgcccag gcgacgggta cagtggaaag gtcgacgcgt aaaacgtgtt ttgcgacccg 16800 gcaccaccgt agtctttacg cccggtgagc gctccacccg cacctacaag cgcgtgtatg 16860

atgaggtgta cggcgacgag gacctgcttg agcaggccaa cgagcgcctc ggggagtttg 16920

cctacggaaa gcggcataag gacatgctgg cgttgccgct ggacgagggc aacccaacac 16980

ctagcctaaa gcccgtaaca ctgcagcagg tgctgcccgc gcttgcaccg tccgaagaaa 17040

agcgcggcct aaagcgcgag tctggtgact tggcacccac cgtgcagctg atggtaccca 17100 agcgccagcg actggaagat gtcttggaaa aaatgaccgt ggaacctggg ctggagcccg 17160

aggtccgcgt gcggccaatc aagcaggtgg cgccgggact gggcgtgcag accgtggacg 17220

ttcagatacc cactaccagt agcaccagta ttgccaccgc cacagagggc atggagacac 17280 aaacgtcccc ggttgcctca gcggtggcgg atgccgcggt gcaggcggtc gctgcggccg 17340

cgtccaagac ctctacggag gtgcaaacgg acccgtggat gtttcgcgtt tcagcccccc 17400 ggcgcccgcg cggttcgagg aagtacggcg ccgccagcgc gctactgccc gaatatgccc 17460 tacatccttc cattgcgcct acccccggct atcgtggcta cacctaccgc cccagaagac 17520

gagcaactac ccgacgccga accaccactg gaacccgccg ccgccgtcgc cgtcgccagc 17580 ccgtgctggc cccgatttcc gtgcgcaggg tggctcgcga aggaggcagg accctggtgc 17640 tgccaacagc gcgctaccac cccagcatcg tttaaaagcc ggtctttgtg gttcttgcag 17700

atatggccct cacctgccgc ctccgtttcc cggtgccggg attccgagga agaatgcacc 17760 gtaggagggg catggccggc cacggcctga cgggcggcat gcgtcgtgcg caccaccggc 17820

ggcggcgcgc gtcgcaccgt cgcatgcgcg gcggtatcct gcccctcctt attccactga 17880 tcgccgcggc gattggcgcc gtgcccggaa ttgcatccgt ggccttgcag gcgcagagac 17940 actgattaaa aacaagttgc atgtggaaaa atcaaaataa aaagtctgga ctctcacgct 18000

cgcttggtcc tgtaactatt ttgtagaatg gaagacatca actttgcgtc tctggccccg 18060 Page 173

Sequence_Listing.txt cgacacggct cgcgcccgtt catgggaaac tggcaagata tcggcaccag caatatgagc 18120

ggtggcgcct tcagctgggg ctcgctgtgg agcggcatta aaaatttcgg ttccaccgtt 18180 aagaactatg gcagcaaggc ctggaacagc agcacaggcc agatgctgag ggataagttg 18240

aaagagcaaa atttccaaca aaaggtggta gatggcctgg cctctggcat tagcggggtg 18300 gtggacctgg ccaaccaggc agtgcaaaat aagattaaca gtaagcttga tccccgccct 18360 cccgtagagg agcctccacc ggccgtggag acagtgtctc cagaggggcg tggcgaaaag 18420

cgtccgcgcc ccgacaggga agaaactctg gtgacgcaaa tagacgagcc tccctcgtac 18480 gaggaggcac taaagcaagg cctgcccacc acccgtccca tcgcgcccat ggctaccgga 18540 gtgctgggcc agcacacacc cgtaacgctg gacctgcctc cccccgccga cacccagcag 18600

aaacctgtgc tgccaggccc gaccgccgtt gttgtaaccc gtcctagccg cgcgtccctg 18660 cgccgcgccg ccagcggtcc gcgatcgttg cggcccgtag ccagtggcaa ctggcaaagc 18720 acactgaaca gcatcgtggg tctgggggtg caatccctga agcgccgacg atgcttctga 18780

atagctaacg tgtcgtatgt gtgtcatgta tgcgtccatg tcgccgccag aggagctgct 18840 gagccgccgc gcgcccgctt tccaagatgg ctaccccttc gatgatgccg cagtggtctt 18900

acatgcacat ctcgggccag gacgcctcgg agtacctgag ccccgggctg gtgcagtttg 18960

cccgcgccac cgagacgtac ttcagcctga ataacaagtt tagaaacccc acggtggcgc 19020

ctacgcacga cgtgaccaca gaccggtccc agcgtttgac gctgcggttc atccctgtgg 19080

accgtgagga tactgcgtac tcgtacaagg cgcggttcac cctagctgtg ggtgataacc 19140 gtgtgctgga catggcttcc acgtactttg acatccgcgg cgtgctggac aggggcccta 19200

cttttaagcc ctactctggc actgcctaca acgccctggc tcccaagggt gccccaaatc 19260

cttgcgaatg ggatgaagct gctactgctc ttgaaataaa cctagaagaa gaggacgatg 19320 acaacgaaga cgaagtagac gagcaagctg agcagcaaaa aactcacgta tttgggcagg 19380

cgccttattc tggtataaat attacaaagg agggtattca aataggtgtc gaaggtcaaa 19440 cacctaaata tgccgataaa acatttcaac ctgaacctca aataggagaa tctcagtggt 19500 acgaaactga aattaatcat gcagctggga gagtccttaa aaagactacc ccaatgaaac 19560

catgttacgg ttcatatgca aaacccacaa atgaaaatgg agggcaaggc attcttgtaa 19620 agcaacaaaa tggaaagcta gaaagtcaag tggaaatgca atttttctca actactgagg 19680 cgaccgcagg caatggtgat aacttgactc ctaaagtggt attgtacagt gaagatgtag 19740

atatagaaac cccagacact catatttctt acatgcccac tattaaggaa ggtaactcac 19800 gagaactaat gggccaacaa tctatgccca acaggcctaa ttacattgct tttagggaca 19860

attttattgg tctaatgtat tacaacagca cgggtaatat gggtgttctg gcgggccaag 19920 catcgcagtt gaatgctgtt gtagatttgc aagacagaaa cacagagctt tcataccagc 19980 ttttgcttga ttccattggt gatagaacca ggtacttttc tatgtggaat caggctgttg 20040

acagctatga tccagatgtt agaattattg aaaatcatgg aactgaagat gaacttccaa 20100 Page 174

Sequence_Listing.txt attactgctt tccactggga ggtgtgatta atacagagac tcttaccaag gtaaaaccta 20160

aaacaggtca ggaaaatgga tgggaaaaag atgctacaga attttcagat aaaaatgaaa 20220 taagagttgg aaataatttt gccatggaaa tcaatctaaa tgccaacctg tggagaaatt 20280

tcctgtactc caacatagcg ctgtatttgc ccgacaagct aaagtacagt ccttccaacg 20340 taaaaatttc tgataaccca aacacctacg actacatgaa caagcgagtg gtggctcccg 20400 ggttagtgga ctgctacatt aaccttggag cacgctggtc ccttgactat atggacaacg 20460

tcaacccatt taaccaccac cgcaatgctg gcctgcgcta ccgctcaatg ttgctgggca 20520 atggtcgcta tgtgcccttc cacatccagg tgcctcagaa gttctttgcc attaaaaacc 20580 tccttctcct gccgggctca tacacctacg agtggaactt caggaaggat gttaacatgg 20640

ttctgcagag ctccctagga aatgacctaa gggttgacgg agccagcatt aagtttgata 20700 gcatttgcct ttacgccacc ttcttcccca tggcccacaa caccgcctcc acgcttgagg 20760 ccatgcttag aaacgacacc aacgaccagt cctttaacga ctatctctcc gccgccaaca 20820

tgctctaccc tatacccgcc aacgctacca acgtgcccat atccatcccc tcccgcaact 20880 gggcggcttt ccgcggctgg gccttcacgc gccttaagac taaggaaacc ccatcactgg 20940

gctcgggcta cgacccttat tacacctact ctggctctat accctaccta gatggaacct 21000

tttacctcaa ccacaccttt aagaaggtgg ccattacctt tgactcttct gtcagctggc 21060

ctggcaatga ccgcctgctt acccccaacg agtttgaaat taagcgctca gttgacgggg 21120

agggttacaa cgttgcccag tgtaacatga ccaaagactg gttcctggta caaatgctag 21180 ctaactacaa cattggctac cagggcttct atatcccaga gagctacaag gaccgcatgt 21240

actccttctt tagaaacttc cagcccatga gccgtcaggt ggtggatgat actaaataca 21300

aggactacca acaggtgggc atcctacacc aacacaacaa ctctggattt gttggctacc 21360 ttgcccccac catgcgcgaa ggacaggcct accctgctaa cttcccctat ccgcttatag 21420

gcaagaccgc agttgacagc attacccaga aaaagtttct ttgcgatcgc accctttggc 21480 gcatcccatt ctccagtaac tttatgtcca tgggcgcact cacagacctg ggccaaaacc 21540 ttctctacgc caactccgcc cacgcgctag acatgacttt tgaggtggat cccatggacg 21600

agcccaccct tctttatgtt ttgtttgaag tctttgacgt ggtccgtgtg caccggccgc 21660 accgcggcgt catcgaaacc gtgtacctgc gcacgccctt ctcggccggc aacgccacaa 21720 cataaagaag caagcaacat caacaacagc tgccgccatg ggctccagtg agcaggaact 21780

gaaagccatt gtcaaagatc ttggttgtgg gccatatttt ttgggcacct atgacaagcg 21840 ctttccaggc tttgtttctc cacacaagct cgcctgcgcc atagtcaata cggccggtcg 21900

cgagactggg ggcgtacact ggatggcctt tgcctggaac ccgcactcaa aaacatgcta 21960 cctctttgag ccctttggct tttctgacca gcgactcaag caggtttacc agtttgagta 22020 cgagtcactc ctgcgccgta gcgccattgc ttcttccccc gaccgctgta taacgctgga 22080

aaagtccacc caaagcgtac aggggcccaa ctcggccgcc tgtggactat tctgctgcat 22140 Page 175

Sequence_Listing.txt gtttctccac gcctttgcca actggcccca aactcccatg gatcacaacc ccaccatgaa 22200

ccttattacc ggggtaccca actccatgct caacagtccc caggtacagc ccaccctgcg 22260 tcgcaaccag gaacagctct acagcttcct ggagcgccac tcgccctact tccgcagcca 22320

cagtgcgcag attaggagcg ccacttcttt ttgtcacttg aaaaacatgt aaaaataatg 22380 tactagagac actttcaata aaggcaaatg cttttatttg tacactctcg ggtgattatt 22440 tacccccacc cttgccgtct gcgccgttta aaaatcaaag gggttctgcc gcgcatcgct 22500

atgcgccact ggcagggaca cgttgcgata ctggtgttta gtgctccact taaactcagg 22560 cacaaccatc cgcggcagct cggtgaagtt ttcactccac aggctgcgca ccatcaccaa 22620 cgcgtttagc aggtcgggcg ccgatatctt gaagtcgcag ttggggcctc cgccctgcgc 22680

gcgcgagttg cgatacacag ggttgcagca ctggaacact atcagcgccg ggtggtgcac 22740 gctggccagc acgctcttgt cggagatcag atccgcgtcc aggtcctccg cgttgctcag 22800 ggcgaacgga gtcaactttg gtagctgcct tcccaaaaag ggcgcgtgcc caggctttga 22860

gttgcactcg caccgtagtg gcatcaaaag gtgaccgtgc ccggtctggg cgttaggata 22920 cagcgcctgc ataaaagcct tgatctgctt aaaagccacc tgagcctttg cgccttcaga 22980

gaagaacatg ccgcaagact tgccggaaaa ctgattggcc ggacaggccg cgtcgtgcac 23040

gcagcacctt gcgtcggtgt tggagatctg caccacattt cggccccacc ggttcttcac 23100

gatcttggcc ttgctagact gctccttcag cgcgcgctgc ccgttttcgc tcgtcacatc 23160

catttcaatc acgtgctcct tatttatcat aatgcttccg tgtagacact taagctcgcc 23220 ttcgatctca gcgcagcggt gcagccacaa cgcgcagccc gtgggctcgt gatgcttgta 23280

ggtcacctct gcaaacgact gcaggtacgc ctgcaggaat cgccccatca tcgtcacaaa 23340

ggtcttgttg ctggtgaagg tcagctgcaa cccgcggtgc tcctcgttca gccaggtctt 23400 gcatacggcc gccagagctt ccacttggtc aggcagtagt ttgaagttcg cctttagatc 23460

gttatccacg tggtacttgt ccatcagcgc gcgcgcagcc tccatgccct tctcccacgc 23520 agacacgatc ggcacactca gcgggttcat caccgtaatt tcactttccg cttcgctggg 23580 ctcttcctct tcctcttgcg tccgcatacc acgcgccact gggtcgtctt cattcagccg 23640

ccgcactgtg cgcttacctc ctttgccatg cttgattagc accggtgggt tgctgaaacc 23700 caccatttgt agcgccacat cttctctttc ttcctcgctg tccacgatta cctctggtga 23760 tggcgggcgc tcgggcttgg gagaagggcg cttctttttc ttcttgggcg caatggccaa 23820

atccgccgcc gaggtcgatg gccgcgggct gggtgtgcgc ggcaccagcg cgtcttgtga 23880 tgagtcttcc tcgtcctcgg actcgatacg ccgcctcatc cgcttttttg ggggcgcccg 23940

gggaggcggc ggcgacgggg acggggacga cacgtcctcc atggttgggg gacgtcgcgc 24000 cgcaccgcgt ccgcgctcgg gggtggtttc gcgctgctcc tcttcccgac tggccatttc 24060 cttctcctat aggcagaaaa agatcatgga gtcagtcgag aagaaggaca gcctaaccgc 24120

cccctctgag ttcgccacca ccgcctccac cgatgccgcc aacgcgccta ccaccttccc 24180 Page 176

Sequence_Listing.txt cgtcgaggca cccccgcttg aggaggagga agtgattatc gagcaggacc caggttttgt 24240

aagcgaagac gacgaggacc gctcagtacc aacagaggat aaaaagcaag accaggacaa 24300 cgcagaggca aacgaggaac aagtcgggcg gggggacgaa aggcatggcg actacctaga 24360

tgtgggagac gacgtgctgt tgaagcatct gcagcgccag tgcgccatta tctgcgacgc 24420 gttgcaagag cgcagcgatg tgcccctcgc catagcggat gtcagccttg cctacgaacg 24480 ccacctattc tcaccgcgcg taccccccaa acgccaagaa aacggcacat gcgagcccaa 24540

cccgcgcctc aacttctacc ccgtatttgc cgtgccagag gtgcttgcca cctatcacat 24600 ctttttccaa aactgcaaga tacccctatc ctgccgtgcc aaccgcagcc gagcggacaa 24660 gcagctggcc ttgcggcagg gcgctgtcat acctgatatc gcctcgctca acgaagtgcc 24720

aaaaatcttt gagggtcttg gacgcgacga gaagcgcgcg gcaaacgctc tgcaacagga 24780 aaacagcgaa aatgaaagtc actctggagt gttggtggaa ctcgagggtg acaacgcgcg 24840 cctagccgta ctaaaacgca gcatcgaggt cacccacttt gcctacccgg cacttaacct 24900

accccccaag gtcatgagca cagtcatgag tgagctgatc gtgcgccgtg cgcagcccct 24960 ggagagggat gcaaatttgc aagaacaaac agaggagggc ctacccgcag ttggcgacga 25020

gcagctagcg cgctggcttc aaacgcgcga gcctgccgac ttggaggagc gacgcaaact 25080

aatgatggcc gcagtgctcg ttaccgtgga gcttgagtgc atgcagcggt tctttgctga 25140

cccggagatg cagcgcaagc tagaggaaac attgcactac acctttcgac agggctacgt 25200

acgccaggcc tgcaagatct ccaacgtgga gctctgcaac ctggtctcct accttggaat 25260 tttgcacgaa aaccgccttg ggcaaaacgt gcttcattcc acgctcaagg gcgaggcgcg 25320

ccgcgactac gtccgcgact gcgtttactt atttctatgc tacacctggc agacggccat 25380

gggcgtttgg cagcagtgct tggaggagtg caacctcaag gagctgcaga aactgctaaa 25440 gcaaaacttg aaggacctat ggacggcctt caacgagcgc tccgtggccg cgcacctggc 25500

ggacatcatt ttccccgaac gcctgcttaa aaccctgcaa cagggtctgc cagacttcac 25560 cagtcaaagc atgttgcaga actttaggaa ctttatccta gagcgctcag gaatcttgcc 25620 cgccacctgc tgtgcacttc ctagcgactt tgtgcccatt aagtaccgcg aatgccctcc 25680

gccgctttgg ggccactgct accttctgca gctagccaac taccttgcct accactctga 25740 cataatggaa gacgtgagcg gtgacggtct actggagtgt cactgtcgct gcaacctatg 25800 caccccgcac cgctccctgg tttgcaattc gcagctgctt aacgaaagtc aaattatcgg 25860

tacctttgag ctgcagggtc cctcgcctga cgaaaagtcc gcggctccgg ggttgaaact 25920 cactccgggg ctgtggacgt cggcttacct tcgcaaattt gtacctgagg actaccacgc 25980

ccacgagatt aggttctacg aagaccaatc ccgcccgcca aatgcggagc ttaccgcctg 26040 cgtcattacc cagggccaca ttcttggcca attgcaagcc atcaacaaag cccgccaaga 26100 gtttctgcta cgaaagggac ggggggttta cttggacccc cagtccggcg aggagctcaa 26160

cccaatcccc ccgccgccgc agccctatca gcagcagccg cgggcccttg cttcccagga 26220 Page 177

Sequence_Listing.txt tggcacccaa aaagaagctg cagctgccgc cgccacccac ggacgaggag gaatactggg 26280

acagtcaggc agaggaggtt ttggacgagg aggaggagga catgatggaa gactgggaga 26340 gcctagacga ggaagcttcc gaggtcgaag aggtgtcaga cgaaacaccg tcaccctcgg 26400

tcgcattccc ctcgccggcg ccccagaaat cggcaaccgg ttccagcatg gctacaacct 26460 ccgctcctca ggcgccgccg gcactgcccg ttcgccgacc caaccgtaga tgggacacca 26520 ctggaaccag ggccggtaag tccaagcagc cgccgccgtt agcccaagag caacaacagc 26580

gccaaggcta ccgctcatgg cgcgggcaca agaacgccat agttgcttgc ttgcaagact 26640 gtgggggcaa catctccttc gcccgccgct ttcttctcta ccatcacggc gtggccttcc 26700 cccgtaacat cctgcattac taccgtcatc tctacagccc atactgcacc ggcggcagcg 26760

gcagcggcag caacagcagc ggccacacag aagcaaaggc gaccggatag caagactctg 26820 acaaagccca agaaatccac agcggcggca gcagcaggag gaggagcgct gcgtctggcg 26880 cccaacgaac ccgtatcgac ccgcgagctt agaaacagga tttttcccac tctgtatgct 26940

atatttcaac agagcagggg ccaagaacaa gagctgaaaa taaaaaacag gtctctgcga 27000 tccctcaccc gcagctgcct gtatcacaaa agcgaagatc agcttcggcg cacgctggaa 27060

gacgcggagg ctctcttcag taaatactgc gcgctgactc ttaaggacta gtttcgcgcc 27120

ctttctcaaa tttaagcgcg aaaactacgt catctccagc ggccacaccc ggcgccagca 27180

cctgtcgtca gcgccatttc aactttgtat acaaaagttg tgatgagcaa ggaaattccc 27240

acgccctaca tgtggagtta ccagccacaa atgggacttg cggctggagc tgcccaagac 27300 tactcaaccc gaataaacta catgagcgcg ggaccccaca tgatatcccg ggtcaacgga 27360

atacgcgccc accgaaaccg aattctcctg gaacaggcgg ctattaccac cacacctcgt 27420

aataacctta atccccgtag ttggcccgct gccctggtgt accaggaaag tcccgctccc 27480 accactgtgg tacttcccag agacgcccag gccgaagttc agatgactaa ctcaggggcg 27540

cagcttgcgg gcggctttcg tcacagggtg cggtcgcccg ggcagggtat aactcacctg 27600 acaatcagag ggcgaggtat tcagctcaac gacgagtcgg tgagctcctc gcttggtctc 27660 cgtccggacg ggacatttca gatcggcggc gccggccgct cttcattcac gcctcgtcag 27720

gcaatcctaa ctctgcagac ctcgtcctct gagccgcgct ctggaggcat tggaactctg 27780 caatttattg aggagtttgt gccatcggtc tactttaacc ccttctcggg acctcccggc 27840 cactatccgg atcaatttat tcctaacttt gacgcggtaa aggactcggc ggacggctac 27900

gactgaatgt taagtggaga ggcagagcaa ctgcgcctga aacacctggt ccactgtcgc 27960 cgccacaagt gctttgcccg cgactccggt gagttttgct actttgaatt gcccgaggat 28020

catatcgagg gcccggcgca cggcgtccgg cttaccgccc agggagagct tgcccgtagc 28080 ctgattcggg agtttaccca gcgccccctg ctagttgagc gggacagggg accctgtgtt 28140 ctcactgtga tttgcaactg tcctaaccct ggattacatc aagatctttg ttgccatctc 28200

tgtgctgagt ataataaata cagaaattaa aatatactgg ggctcctatc gccatcctgt 28260 Page 178

Sequence_Listing.txt aaacgccacc gtcttcaccc gcccaagcaa accaaggcga accttacctg gtacttttaa 28320

catctctccc tctgtgattt acaacagttt caacccagac ggagtgagtc tacgagagaa 28380 cctctccgag ctcagctact ccatcagaaa aaacaccacc ctccttacct gccgggaacg 28440

tacgagtgcg tcaccggccg ctgcaccaca cctaccgcct gaccgtaaac cagacttttt 28500 ccggacagac ctcaataact ctgtttacca gaacaggagg tgagcttaga aaacccttag 28560 ggtattaggc caaaggcgca gctactgtgg ggtttatgaa caattcaagc aactctacgg 28620

gctattctaa ttcaggtttc tctagaatcg gggttggggt tattctctgt cttgtgattc 28680 tctttattct tatactaacg cttctctgcc taaggctcgc cgcctgctgt gtgcacattt 28740 gcatttattg tcagcttttt aaacgctggg gtcgccaccc aagatgatta ggtacataat 28800

cctaggttta ctcacccttg cgtcagccca cggtaccacc caaaaggtgg attttaagga 28860 gccagcctgt aatgttacat tcgcagctga agctaatgag tgcaccactc ttataaaatg 28920 caccacagaa catgaaaagc tgcttattcg ccacaaaaac aaaattggca agtatgctgt 28980

ttatgctatt tggcagccag gtgacactac agagtataat gttacagttt tccagggtaa 29040 aagtcataaa acttttatgt atacttttcc attttatgaa atgtgcgaca ttaccatgta 29100

catgagcaaa cagtataagt tgtggccccc acaaaattgt gtggaaaaca ctggcacttt 29160

ctgctgcact gctatgctaa ttacagtgct cgctttggtc tgtaccctac tctatattaa 29220

atacaaaagc agacgcagct ttattgagga aaagaaaatg ccttaattta ctaagttaca 29280

aagctaatgt caccactaac tgctttactc gctgcttgca aaacaaattc aaaaagttag 29340 cattataatt agaataggat ttaaaccccc cggtcatttc ctgctcaata ccattcccct 29400

gaacaattga ctctatgtgg gatatgctcc agcgctacaa ccttgaagtc aggcttcctg 29460

gatgtcagca tctgactttg gccagcacct gtcccgcgga tttgttccag tccaactaca 29520 gcgacccacc ctaacagaga tgaccaacac aaccaacgcg gccgccgcta ccggacttac 29580

atctaccaca aatacacccc aagtttctgc ctttgtcaat aactgggata acttgggcat 29640 gtggtggttc tccatagcgc ttatgtttgt atgccttatt attatgtggc tcatctgctg 29700 cctaaagcgc aaacgcgccc gaccacccat ctatagtccc atcattgtgc tacacccaaa 29760

caatgatgga atccatagat tggacggact gaaacacatg ttcttttctc ttacagtatg 29820 attaaatgag acatgattcc tcgagttttt atattactga cccttgttgc gcttttttgt 29880 gcgtgctcca cattggctgc ggtttctcac atcgaagtag actgcattcc agccttcaca 29940

gtctatttgc tttacggatt tgtcaccctc acgctcatct gcagcctcat cactgtggtc 30000 atcgccttta tccagtgcat tgactgggtc tgtgtgcgct ttgcatatct cagacaccat 30060

ccccagtaca gggacaggac tatagctgag cttcttagaa ttctttaatt atgaaattta 30120 ctgtgacttt tctgctgatt atttgcaccc tatctgcgtt ttgttccccg acctccaagc 30180 ctcaaagaca tatatcatgc agattcactc gtatatggaa tattccaagt tgctacaatg 30240

aaaaaagcga tctttccgaa gcctggttat atgcaatcat ctctgttatg gtgttctgca 30300 Page 179

Sequence_Listing.txt gtaccatctt agccctagct atatatccct accttgacat tggctggaac gcaatagatg 30360

ccatgaacca cccaactttc cccgcgcccg ctatgcttcc actgcaacaa gttgttgccg 30420 gcggctttgt cccagccaat cagcctcgcc caccttctcc cacccccact gaaatcagct 30480

actttaatct aacaggagga gatgactgac accctagatc tagaaatgga cggaattatt 30540 acagagcagc gcctgctaga aagacgcagg gcagcggccg agcaacagcg catgaatcaa 30600 gagctccaag acatggttaa cttgcaccag tgcaaaaggg gtatcttttg tctggtaaag 30660

caggccaaag tcacctacga cagtaatacc accggacacc gccttagcta caagttgcca 30720 accaagcgtc agaaattggt ggtcatggtg ggagaaaagc ccattaccat aactcagcac 30780 tcggtagaaa ccgaaggctg cattcactca ccttgtcaag gacctgagga tctctgcacc 30840

cttattaaga ccctgtgcgg tctcaaagat cttattccct ttaactaata aaaaaaaata 30900 ataaagcatc acttacttaa aatcagttag caaatttctg tccagtttat tcagcagcac 30960 ctccttgccc tcctcccagc tctggtattg cagcttcctc ctggctgcaa actttctcca 31020

caatctaaat ggaatgtcag tttcctcctg ttcctgtcca tccgcaccca ctatcttcat 31080 gttgttgcag atgaagcgcg caagaccgtc tgaagatacc ttcaaccccg tgtatccata 31140

tgacacggaa accggtcctc caactgtgcc ttttcttact cctccctttg tatcccccaa 31200

tgggtttcaa gagagtcccc ctggggtact ctctttgcgc ctatccgaac ctctagttac 31260

ctccaatggc atgcttgcgc tcaaaatggg caacggcctc tctctggacg aggccggcaa 31320

ccttacctcc caaaatgtaa ccactgtgag cccacctctc aaaaaaacca agtcaaacat 31380 aaacctggaa atatctgcac ccctcacagt tacctcagaa gccctaactg tggctgccgc 31440

cgcacctcta atggtcgcgg gcaacacact caccatgcaa tcacaggccc cgctaaccgt 31500

gcacgactcc aaacttagca ttgccaccca aggacccctc acagtgtcag aaggaaagct 31560 agccctgcaa acatcaggcc ccctcaccac caccgatagc agtaccctta ctatcactgc 31620

ctcaccccct ctaactactg ccactggtag cttgggcatt gacttgaaag agcccattta 31680 tacacaaaat ggaaaactag gactaaagta cggggctcct ttgcatgtaa cagacgacct 31740 aaacactttg accgtagcaa ctggtccagg tgtgactatt aataatactt ccttgcaaac 31800

taaagttact ggagccttgg gttttgattc acaaggcaat atgcaactta atgtagcagg 31860 aggactaagg attgattctc aaaacagacg ccttatactt gatgttagtt atccgtttga 31920 tgctcaaaac caactaaatc taagactagg acagggccct ctttttataa actcagccca 31980

caacttggat attaactaca acaaaggcct ttacttgttt acagcttcaa acaattccaa 32040 aaagcttgag gttaacctaa gcactgccaa ggggttgatg tttgacgcta cagccatagc 32100

cattaatgca ggagatgggc ttgaatttgg ttcacctaat gcaccaaaca caaatcccct 32160 caaaacaaaa attggccatg gcctagaatt tgattcaaac aaggctatgg ttcctaaact 32220 aggaactggc cttagttttg acagcacagg tgccattaca gtaggaaaca aaaataatga 32280

taagctaact ttgtggacca caccagctcc atctcctaac tgtagactaa atgcagagaa 32340 Page 180

Sequence_Listing.txt agatgctaaa ctcactttgg tcttaacaaa atgtggcagt caaatacttg ctacagtttc 32400

agttttggct gttaaaggca gtttggctcc aatatctgga acagttcaaa gtgctcatct 32460 tattataaga tttgacgaaa atggagtgct actaaacaat tccttcctgg acccagaata 32520

ttggaacttt agaaatggag atcttactga aggcacagcc tatacaaacg ctgttggatt 32580 tatgcctaac ctatcagctt atccaaaatc tcacggtaaa actgccaaaa gtaacattgt 32640 cagtcaagtt tacttaaacg gagacaaaac taaacctgta acactaacca ttacactaaa 32700

cggtacacag gaaacaggag acacaactcc aagtgcatac tctatgtcat tttcatggga 32760 ctggtctggc cacaactaca ttaatgaaat atttgccaca tcctcttaca ctttttcata 32820 cattgcccaa gaataaagaa tcgtttgtgt tatgtttcaa cgtgtttatt tttcaattgc 32880

agaaaatttc aagtcatttt tcattcagta gtatagcccc accaccacat agcttataca 32940 gatcaccgta cctcaacttt gtataataaa gttgaatcaa actcacagaa ccctagtatt 33000 caacctgcca cctccctccc aacacacaga gtacacagtc ctttctcccc ggctggcctt 33060

aaaaagcatc atatcatggg taacagacat attcttaggt gttatattcc acacggtttc 33120 ctgtcgagcc aaacgctcat cagtgatatt aataaactcc ccgggcagct cacttaagtt 33180

catgtcgctg tccagctgct gagccacagg ctgctgtcca acttgcggtt gcttaacggg 33240

cggcgaagga gaagtccacg cctacatggg ggtagagtca taatcgtgca tcaggatagg 33300

gcggtggtgc tgcagcagcg cgcgaataaa ctgctgccgc cgccgctccg tcctgcagga 33360

atacaacatg gcagtggtct cctcagcgat gattcgcacc gcccgcagca taaggcgcct 33420 tgtcctccgg gcacagcagc gcaccctgat ctcacttaaa tcagcacagt aactgcagca 33480

cagcaccaca atattgttca aaatcccaca gtgcaaggcg ctgtatccaa agctcatggc 33540

ggggaccaca gaacccacgt ggccatcata ccacaagcgc aggtagatta agtggcgacc 33600 cctcataaac acgctggaca taaacattac ctcttttggc atgttgtaat tcaccacctc 33660

ccggtaccat ataaacctct gattaaacat ggcgccatcc accaccatcc taaaccagct 33720 ggccaaaacc tgcccgccgg ctatacactg cagggaaccg ggactggaac aatgacagtg 33780 gagagcccag gactcgtaac catggatcat catgctcgtc atgatatcaa tgttggcaca 33840

acacaggcac acgtgcatac acttcctcag gattacaagc tcctcccgcg ttagaaccat 33900 atcccaggga acaacccatt cctgaatcag cgtaaatccc acactgcagg gaagacctcg 33960 cacgtaactc acgttgtgca ttgtcaaagt gttacattcg ggcagcagcg gatgatcctc 34020

cagtatggta gcgcgggttt ctgtctcaaa aggaggtaga cgatccctac tgtacggagt 34080 gcgccgagac aaccgagatc gtgttggtcg tagtgtcatg ccaaatggaa cgccggacgt 34140

agtcatattt cctgaagcaa aaccaggtgc gggcgtgaca aacagatctg cgtctccggt 34200 ctcgccgctt agatcgctct gtgtagtagt tgtagtatat ccactctctc aaagcatcca 34260 ggcgccccct ggcttcgggt tctatgtaaa ctccttcatg cgccgctgcc ctgataacat 34320

ccaccaccgc agaataagcc acacccagcc aacctacaca ttcgttctgc gagtcacaca 34380 Page 181

Sequence_Listing.txt cgggaggagc gggaagagct ggaagaacca tgtttttttt tttattccaa aagattatcc 34440

aaaacctcaa aatgaagatc tattaagtga acgcgctccc ctccggtggc gtggtcaaac 34500 tctacagcca aagaacagat aatggcattt gtaagatgtt gcacaatggc ttccaaaagg 34560

caaacggccc tcacgtccaa gtggacgtaa aggctaaacc cttcagggtg aatctcctct 34620 ataaacattc cagcaccttc aaccatgccc aaataattct catctcgcca ccttctcaat 34680 atatctctaa gcaaatcccg aatattaagt ccggccattg taaaaatctg ctccagagcg 34740

ccctccacct tcagcctcaa gcagcgaatc atgattgcaa aaattcaggt tcctcacaga 34800 cctgtataag attcaaaagc ggaacattaa caaaaatacc gcgatcccgt aggtcccttc 34860 gcagggccag ctgaacataa tcgtgcaggt ctgcacggac cagcgcggcc acttccccgc 34920

caggaaccat gacaaaagaa cccacactga ttatgacacg catactcgga gctatgctaa 34980 ccagcgtagc cccgatgtaa gcttgttgca tgggcggcga tataaaatgc aaggtgctgc 35040 tcaaaaaatc aggcaaagcc tcgcgcaaaa aagaaagcac atcgtagtca tgctcatgca 35100

gataaaggca ggtaagctcc ggaaccacca cagaaaaaga caccattttt ctctcaaaca 35160 ttgggccagg attctcctcg acgtcaccag cctgcttcag caggctgaag ttagtagctc 35220

cgcttccctt atagagctcg ttcatgccct cggtgatgcc ggcggcggtc aggaactcca 35280

gcagcaccat gtggtcccgc ttctcgttgg ggtccttgaa cagggcgctc tggtagctca 35340

ggtagtggtt gtcgggcagc agcacggggc cgtcgccgat gggggtgttc tgctggtagt 35400

ggtcggccag ctgcacgccg ccgtcctcga tgttgtgccg gatcttgaag ttggccttga 35460 tgccgttctt ctgcttgtcg gcggtgatgt acacgttgtg gctgttgtag ttgtactcca 35520

gcttgtggcc caggatgttg ccgtcctcct tgaagtcgat gcccttcagc tcgatccggt 35580

tcaccagggt gtcgccctcg aacttcacct cggcccgggt cttgtagttg ccgtcgtcct 35640 tgaagaagat ggtccgctcc tgcacgtagc cctcgggcat ggcgctcttg aagaagtcgt 35700

gctgcttcat gtggtcgggg taccgggcga agcactgcac gccgtagccc agggtggtca 35760 ccagggtggg ccagggcacg ggcagcttgc cggtggtgca cagcagcttc agggtcagct 35820 tgccgtaggt ggcgtcgccc tcgccctcgc cgctcacgct gaacttgtgg ccgttcacgt 35880

cgccgtccag ctccaccagg atgggcacca cgccggtgaa cagctcttcg cctttgctca 35940 ccatgtctgc gggtttctgc ataaacacaa aataaaataa caaaaaaaca tttaaacatt 36000 agaagcctgt cttacaacag gaaaaacaac ccttataagc ataagacgga ctacggccat 36060

gccggcgtga ccgtaaaaaa actggtcacc gtgattaaaa agcaccaccg acagctcctc 36120 ggtcatgtcc ggagtcataa tgtaagactc ggtaaacaca tcaggttgat tcacatcggt 36180

cagtgctaaa aagcgaccga aatagcccgg gggaatacat acccgcaggc gtagagacaa 36240 cattacagcc cccataggag gtataacaaa attaatagga gagaaaaaca cataaacacc 36300 tgaaaaaccc tcctgcctag gcaaaatagc accctcccgc tccagaacaa catacagcgc 36360

ttccacagcg gcagccataa cagtcagcct taccagtaaa aaagaaaacc tattaaaaaa 36420 Page 182

Sequence_Listing.txt acaccactcg acacggcacc agctcaatca gtcacagtgt aaaaaagggc caagtgcaga 36480

gcgagtatat ataggactaa aaaatgacgt aacggttaaa gtccacaaaa aacacccaga 36540 aaaccgcacg cgaacctacg cccagaaacg aaagccaaaa aacccacaac ttcctcaaat 36600

cgtcacttcc gttttcccac gttacgtcac ttcccatttt aagaaaacta caattcccaa 36660 cacatacaag ttactccgcc ctaaaaccta cgtcacccgc cccgttccca cgccccgcgc 36720 cacgtcacaa actccacccc ctcattatca tattggcttc aatccaaaat aaggtatatt 36780

attgatgatg 36790

<210> 11 <211> 36781 <212> DNA <213> Artificial Sequence <220> <223> Synthetic adenovirus genome mCherry-P2A-E4-ORF2 <400> 11 catcatcaat aatatacctt attttggatt gaagccaata tgataatgag ggggtggagt 60 ttgtgacgtg gcgcggggcg tgggaacggg gcgggtgacg tagtagtgtg gcggaagtgt 120

gatgttgcaa gtgtggcgga acacatgtaa gcgacggatg tggcaaaagt gacgtttttg 180

gtgtgcgccg gtgtacacag gaagtgacaa ttttcgcgcg gttttaggcg gatgttgtag 240

taaatttggg cgtaaccgag taagatttgg ccattttcgc gggaaaactg aataagagga 300

agtgaaatct gaataatttt gtgttactca tagcgcgtaa tatttgtcta gggccgcggg 360 gactttgacc gtttacgtgg agactcgccc aggtgttttt ctcaggtgtt ttccgcgttc 420

cgggtcaaag ttggcgtttt attattatag tcagctgacg tgtagtgtat ttatacccgg 480

tgagttcctc aagaggccac tcttgagtgc cagcgagtag agttttctcc tccgagccgc 540 tccgacaccg ggactgaaaa tgagacatat tatctgccac ggaggtgtta ttaccgaaga 600

aatggccgcc agtcttttgg accagctgat cgaagaggta ctggctgata atcttccacc 660 tcctagccat tttgaaccac ctacccttca cgaactgtat gatttagacg tgacggcccc 720 cgaagatccc aacgaggagg cggtttcgca gatttttccc gactctgtaa tgttggcggt 780

gcaggaaggg attgacttac tcacttttcc gccggcgccc ggttctccgg agccgcctca 840 cctttcccgg cagcccgagc agccggagca gagagccttg ggtccggttt ctatgccaaa 900 ccttgtaccg gaggtgatcg atcttacctg ccacgaggct ggctttccac ccagtgacga 960

cgaggatgaa gagggtgagg agtttgtgtt agattatgtg gagcaccccg ggcacggttg 1020 caggtcttgt cattatcacc ggaggaatac gggggaccca gatattatgt gttcgctttg 1080

ctatatgagg acctgtggca tgtttgtcta cagtaagtga aaattatggg cagtgggtga 1140 tagagtggtg ggtttggtgt ggtaattttt tttttaattt ttacagtttt gtggtttaaa 1200 gaattttgta ttgtgatttt tttaaaaggt cctgtgtctg aacctgagcc tgagcccgag 1260

ccagaaccgg agcctgcaag acctacccgc cgtcctaaaa tggcgcctgc tatcctgaga 1320 Page 183

Sequence_Listing.txt cgcccgacat cacctgtgtc tagagaatgc aatagtagta cggatagctg tgactccggt 1380

ccttctaaca cacctcctga gatacacccg gtggtcccgc tgtgccccat taaaccagtt 1440 gccgtgagag ttggtgggcg tcgccaggct gtggaatgta tcgaggactt gcttaacgag 1500

cctgggcaac ctttggactt gagctgtaaa cgccccaggc cataaggtgt aaacctgtga 1560 ttgcgtgtgt ggttaacgcc tttgtttgct gaatgagttg atgtaagttt aataaagggt 1620 gagataatgt ttaacttgca tggcgtgtta aatggggcgg ggcttaaagg gtatataatg 1680

cgccgtgggc taatcttggt tacatctgac ctcatggagg cttgggagtg tttggaagat 1740 ttttctgctg tgcgtaactt gctggaacag agctctaaca gtacctcttg gttttggagg 1800 tttctgtggg gctcatccca ggcaaagtta gtctgcagaa ttaaggagga ttacaagtgg 1860

gaatttgaag agcttttgaa atcctgtggt gagctgtttg attctttgaa tctgggtcac 1920 caggcgcttt tccaagagaa ggtcatcaag actttggatt tttccacacc ggggcgcgct 1980 gcggctgctg ttgctttttt gagttttata aaggataaat ggagcgaaga aacccatctg 2040

agcggggggt acctgctgga ttttctggcc atgcatctgt ggagagcggt tgtgagacac 2100 aagaatcgcc tgctactgtt gtcttccgtc cgcccggcga taataccgac ggaggagcag 2160

cagcagcagc aggaggaagc caggcggcgg cggcaggagc agagcccatg gaacccgaga 2220

gccggcctgg accctcggga atgaatgttg tacaggtggc tgaactgtat ccagaactga 2280

gacgcatttt gacaattaca gaggatgggc aggggctaaa gggggtaaag agggagcggg 2340

gggcttgtga ggctacagag gaggctagga atctagcttt tagcttaatg accagacacc 2400 gtcctgagtg tattactttt caacagatca aggataattg cgctaatgag cttgatctgc 2460

tggcgcagaa gtattccata gagcagctga ccacttactg gctgcagcca ggggatgatt 2520

ttgaggaggc tattagggta tatgcaaagg tggcacttag gccagattgc aagtacaaga 2580 tcagcaaact tgtaaatatc aggaattgtt gctacatttc tgggaacggg gccgaggtgg 2640

agatagatac ggaggatagg gtggccttta gatgtagcat gataaatatg tggccggggg 2700 tgcttggcat ggacggggtg gttattatga atgtaaggtt tactggcccc aattttagcg 2760 gtacggtttt cctggccaat accaacctta tcctacacgg tgtaagcttc tatgggttta 2820

acaatacctg tgtggaagcc tggaccgatg taagggttcg gggctgtgcc ttttactgct 2880 gctggaaggg ggtggtgtgt cgccccaaaa gcagggcttc aattaagaaa tgcctctttg 2940 aaaggtgtac cttgggtatc ctgtctgagg gtaactccag ggtgcgccac aatgtggcct 3000

ccgactgtgg ttgcttcatg ctagtgaaaa gcgtggctgt gattaagcat aacatggtat 3060 gtggcaactg cgaggacagg gcctctcaga tgctgacctg ctcggacggc aactgtcacc 3120

tgctgaagac cattcacgta gccagccact ctcgcaaggc ctggccagtg tttgagcata 3180 acatactgac ccgctgttcc ttgcatttgg gtaacaggag gggggtgttc ctaccttacc 3240 aatgcaattt gagtcacact aagatattgc ttgagcccga gagcatgtcc aaggtgaacc 3300

tgaacggggt gtttgacatg accatgaaga tctggaaggt gctgaggtac gatgagaccc 3360 Page 184

Sequence_Listing.txt gcaccaggtg cagaccctgc gagtgtggcg gtaaacatat taggaaccag cctgtgatgc 3420

tggatgtgac cgaggagctg aggcccgatc acttggtgct ggcctgcacc cgcgctgagt 3480 ttggctctag cgatgaagat acagattgag gtactgaaat gtgtgggcgt ggcttaaggg 3540

tgggaaagaa tatataaggt gggggtctta tgtagttttg tatctgtttt gcagcagccg 3600 ccgccgccca acttttctat acaaagttgt aatgagcacc aactcgtttg atggaagcat 3660 tgtgagctca tatttgacaa cgcgcatgcc cccatgggcc ggggtgcgtc agaatgtgat 3720

gggctccagc attgatggtc gccccgtcct gcccgcaaac tctactacct tgacctacga 3780 gaccgtgtct ggaacgccgt tggagactgc agcctccgcc gccgcttcag ccgctgcagc 3840 caccgcccgc gggattgtga ctgactttgc tttcctgagc ccgcttgcaa gcagtgcagc 3900

ttcccgttca tccgcccgcg atgacaagtt gacggctctt ttggcacaat tggattcttt 3960 gacccgggaa cttaatgtcg tttctcagca gctgttggat ctgcgccagc aggtttctgc 4020 cctgaaggct tcctcccctc ccaatgcggt ttaaaacata aataaaaaac cagactctgt 4080

ttggatttgg atcaagcata agtgtcttgc tgtctttatt taggggtttt gcgcgcgcgg 4140 taggcccggg accagcggtc tcggtcgttg agggtcctgt gtattttttc caggacgtgg 4200

taaaggtgac tctggatgtt cagatacatg ggcataagcc cgtctctggg gtggaggtag 4260

caccactgca gagcttcatg ctgcggggtg gtgttgtaga tgatccagtc gtagcaggag 4320

cgctgggcgt ggtgcctaaa aatgtctttc agtagcaagc tgattgccag gggcaggccc 4380

ttggtgtaag tgtttacaaa gcggttaagc tgggatgggt gcatacgtgg ggatatgaga 4440 tgcatcttgg actgtatttt taggttggct atgttcccag ccatatccct ccggggattc 4500

atgttgtgca gaaccaccag cacagtgtat ccggtgcact tgggaaattt gtcatgtagc 4560

ttagaaggaa atgcgtggaa gaacttggag acgcccttgt gacctccaag attttccatg 4620 cattcgtcca taatgatggc aatgggccca cgggcggcgg cctgggcgaa gatatttctg 4680

ggatcactaa cgtcatagtt gtgttccagg atgagatcgt cataggccat ttttacaaag 4740 cgcgggcgga gggtgccaga ctgcggtata atggttccat ccggcccagg ggcgtagtta 4800 ccctcacaga tttgcatttc ccacgctttg agttcagatg gggggatcat gtctacctgc 4860

ggggcgatga agaaaacggt ttccggggta ggggagatca gctgggaaga aagcaggttc 4920 ctgagcagct gcgacttacc gcagccggtg ggcccgtaaa tcacacctat taccgggtgc 4980 aactggtagt taagagagct gcagctgccg tcatccctga gcaggggggc cacttcgtta 5040

agcatgtccc tgactcgcat gttttccctg accaaatccg ccagaaggcg ctcgccgccc 5100 agcgatagca gttcttgcaa ggaagcaaag tttttcaacg gtttgagacc gtccgccgta 5160

ggcatgcttt tgagcgtttg accaagcagt tccaggcggt cccacagctc ggtcacctgc 5220 tctacggcat ctcgatccag catatctcct cgtttcgcgg gttggggcgg ctttcgctgt 5280 acggcagtag tcggtgctcg tccagacggg ccagggtcat gtctttccac gggcgcaggg 5340

tcctcgtcag cgtagtctgg gtcacggtga aggggtgcgc tccgggctgc gcgctggcca 5400 Page 185

Sequence_Listing.txt gggtgcgctt gaggctggtc ctgctggtgc tgaagcgctg ccggtcttcg ccctgcgcgt 5460

cggccaggta gcatttgacc atggtgtcat agtccagccc ctccgcggcg tggcccttgg 5520 cgcgcagctt gcccttggag gaggcgccgc acgaggggca gtgcagactt ttgagggcgt 5580

agagcttggg cgcgagaaat accgattccg gggagtaggc atccgcgccg caggccccgc 5640 agacggtctc gcattccacg agccaggtga gctctggccg ttcggggtca aaaaccaggt 5700 ttcccccatg ctttttgatg cgtttcttac ctctggtttc catgagccgg tgtccacgct 5760

cggtgacgaa aaggctgtcc gtgtccccgt atacagactt gagaggcctg tcctcgagcg 5820 gtgttccgcg gtcctcctcg tatagaaact cggaccactc tgagacaaag gctcgcgtcc 5880 aggccagcac gaaggaggct aagtgggagg ggtagcggtc gttgtccact agggggtcca 5940

ctcgctccag ggtgtgaaga cacatgtcgc cctcttcggc atcaaggaag gtgattggtt 6000 tgtaggtgta ggccacgtga ccgggtgttc ctgaaggggg gctataaaag ggggtggggg 6060 cgcgttcgtc ctcactctct tccgcatcgc tgtctgcgag ggccagctgt tggggtgagt 6120

actccctctg aaaagcgggc atgacttctg cgctaagatt gtcagtttcc aaaaacgagg 6180 aggatttgat attcacctgg cccgcggtga tgcctttgag ggtggccgca tccatctggt 6240

cagaaaagac aatctttttg ttgtcaagct tggtggcaaa cgacccgtag agggcgttgg 6300

acagcaactt ggcgatggag cgcagggttt ggtttttgtc gcgatcggcg cgctccttgg 6360

ccgcgatgtt tagctgcacg tattcgcgcg caacgcaccg ccattcggga aagacggtgg 6420

tgcgctcgtc gggcaccagg tgcacgcgcc aaccgcggtt gtgcagggtg acaaggtcaa 6480 cgctggtggc tacctctccg cgtaggcgct cgttggtcca gcagaggcgg ccgcccttgc 6540

gcgagcagaa tggcggtagg gggtctagct gcgtctcgtc cggggggtct gcgtccacgg 6600

taaagacccc gggcagcagg cgcgcgtcga agtagtctat cttgcatcct tgcaagtcta 6660 gcgcctgctg ccatgcgcgg gcggcaagcg cgcgctcgta tgggttgagt gggggacccc 6720

atggcatggg gtgggtgagc gcggaggcgt acatgccgca aatgtcgtaa acgtagaggg 6780 gctctctgag tattccaaga tatgtagggt agcatcttcc accgcggatg ctggcgcgca 6840 cgtaatcgta tagttcgtgc gagggagcga ggaggtcggg accgaggttg ctacgggcgg 6900

gctgctctgc tcggaagact atctgcctga agatggcatg tgagttggat gatatggttg 6960 gacgctggaa gacgttgaag ctggcgtctg tgagacctac cgcgtcacgc acgaaggagg 7020 cgtaggagtc gcgcagcttg ttgaccagct cggcggtgac ctgcacgtct agggcgcagt 7080

agtccagggt ttccttgatg atgtcatact tatcctgtcc cttttttttc cacagctcgc 7140 ggttgaggac aaactcttcg cggtctttcc agtactcttg gatcggaaac ccgtcggcct 7200

ccgaacggta agagcctagc atgtagaact ggttgacggc ctggtaggcg cagcatccct 7260 tttctacggg tagcgcgtat gcctgcgcgg ccttccggag cgaggtgtgg gtgagcgcaa 7320 aggtgtccct gaccatgact ttgaggtact ggtatttgaa gtcagtgtcg tcgcatccgc 7380

cctgctccca gagcaaaaag tccgtgcgct ttttggaacg cggatttggc agggcgaagg 7440 Page 186

Sequence_Listing.txt tgacatcgtt gaagagtatc tttcccgcgc gaggcataaa gttgcgtgtg atgcggaagg 7500

gtcccggcac ctcggaacgg ttgttaatta cctgggcggc gagcacgatc tcgtcaaagc 7560 cgttgatgtt gtggcccaca atgtaaagtt ccaagaagcg cgggatgccc ttgatggaag 7620

gcaatttttt aagttcctcg taggtgagct cttcagggga gctgagcccg tgctctgaaa 7680 gggcccagtc tgcaagatga gggttggaag cgacgaatga gctccacagg tcacgggcca 7740 ttagcatttg caggtggtcg cgaaaggtcc taaactggcg acctatggcc attttttctg 7800

gggtgatgca gtagaaggta agcgggtctt gttcccagcg gtcccatcca aggttcgcgg 7860 ctaggtctcg cgcggcagtc actagaggct catctccgcc gaacttcatg accagcatga 7920 agggcacgag ctgcttccca aaggccccca tccaagtata ggtctctaca tcgtaggtga 7980

caaagagacg ctcggtgcga ggatgcgagc cgatcgggaa gaactggatc tcccgccacc 8040 aattggagga gtggctattg atgtggtgaa agtagaagtc cctgcgacgg gccgaacact 8100 cgtgctggct tttgtaaaaa cgtgcgcagt actggcagcg gtgcacgggc tgtacatcct 8160

gcacgaggtt gacctgacga ccgcgcacaa ggaagcagag tgggaatttg agcccctcgc 8220 ctggcgggtt tggctggtgg tcttctactt cggctgcttg tccttgaccg tctggctgct 8280

cgaggggagt tacggtggat cggaccacca cgccgcgcga gcccaaagtc cagatgtccg 8340

cgcgcggcgg tcggagcttg atgacaacat cgcgcagatg ggagctgtcc atggtctgga 8400

gctcccgcgg cgtcaggtca ggcgggagct cctgcaggtt tacctcgcat agacgggtca 8460

gggcgcgggc tagatccagg tgatacctaa tttccagggg ctggttggtg gcggcgtcga 8520 tggcttgcaa gaggccgcat ccccgcggcg cgactacggt accgcgcggc gggcggtggg 8580

ccgcgggggt gtccttggat gatgcatcta aaagcggtga cgcgggcgag cccccggagg 8640

tagggggggc tccggacccg ccgggagagg gggcaggggc acgtcggcgc cgcgcgcggg 8700 caggagctgg tgctgcgcgc gtaggttgct ggcgaacgcg acgacgcggc ggttgatctc 8760

ctgaatctgg cgcctctgcg tgaagacgac gggcccggtg agcttgagcc tgaaagagag 8820 ttcgacagaa tcaatttcgg tgtcgttgac ggcggcctgg cgcaaaatct cctgcacgtc 8880 tcctgagttg tcttgatagg cgatctcggc catgaactgc tcgatctctt cctcctggag 8940

atctccgcgt ccggctcgct ccacggtggc ggcgaggtcg ttggaaatgc gggccatgag 9000 ctgcgagaag gcgttgaggc ctccctcgtt ccagacgcgg ctgtagacca cgcccccttc 9060 ggcatcgcgg gcgcgcatga ccacctgcgc gagattgagc tccacgtgcc gggcgaagac 9120

ggcgtagttt cgcaggcgct gaaagaggta gttgagggtg gtggcggtgt gttctgccac 9180 gaagaagtac ataacccagc gtcgcaacgt ggattcgttg atatccccca aggcctcaag 9240

gcgctccatg gcctcgtaga agtccacggc gaagttgaaa aactgggagt tgcgcgccga 9300 cacggttaac tcctcctcca gaagacggat gagctcggcg acagtgtcgc gcacctcgcg 9360 ctcaaaggct acaggggcct cttcttcttc ttcaatctcc tcttccataa gggcctcccc 9420

ttcttcttct tctggcggcg gtgggggagg ggggacacgg cggcgacgac ggcgcaccgg 9480 Page 187

Sequence_Listing.txt gaggcggtcg acaaagcgct cgatcatctc cccgcggcga cggcgcatgg tctcggtgac 9540

ggcgcggccg ttctcgcggg ggcgcagttg gaagacgccg cccgtcatgt cccggttatg 9600 ggttggcggg gggctgccat gcggcaggga tacggcgcta acgatgcatc tcaacaattg 9660

ttgtgtaggt actccgccgc cgagggacct gagcgagtcc gcatcgaccg gatcggaaaa 9720 cctctcgaga aaggcgtcta accagtcaca gtcgcaaggt aggctgagca ccgtggcggg 9780 cggcagcggg cggcggtcgg ggttgtttct ggcggaggtg ctgctgatga tgtaattaaa 9840

gtaggcggtc ttgagacggc ggatggtcga cagaagcacc atgtccttgg gtccggcctg 9900 ctgaatgcgc aggcggtcgg ccatgcccca ggcttcgttt tgacatcggc gcaggtcttt 9960 gtagtagtct tgcatgagcc tttctaccgg cacttcttct tctccttcct cttgtcctgc 10020

atctcttgca tctatcgctg cggcggcggc ggagtttggc cgtaggtggc gccctcttcc 10080 tcccatgcgt gtgaccccga agcccctcat cggctgaagc agggctaggt cggcgacaac 10140 gcgctcggct aatatggcct gctgcacctg cgtgagggta gactggaagt catccatgtc 10200

cacaaagcgg tggtatgcgc ccgtgttgat ggtgtaagtg cagttggcca taacggacca 10260 gttaacggtc tggtgacccg gctgcgagag ctcggtgtac ctgagacgcg agtaagccct 10320

cgagtcaaat acgtagtcgt tgcaagtccg caccaggtac tggtatccca ccaaaaagtg 10380

cggcggcggc tggcggtaga ggggccagcg tagggtggcc ggggctccgg gggcgagatc 10440

ttccaacata aggcgatgat atccgtagat gtacctggac atccaggtga tgccggcggc 10500

ggtggtggag gcgcgcggaa agtcgcggac gcggttccag atgttgcgca gcggcaaaaa 10560 gtgctccatg gtcgggacgc tctggccggt caggcgcgcg caatcgttga cgctctagac 10620

cgtgcaaaag gagagcctgt aagcgggcac tcttccgtgg tctggtggat aaattcgcaa 10680

gggtatcatg gcggacgacc ggggttcgag ccccgtatcc ggccgtccgc cgtgatccat 10740 gcggttaccg cccgcgtgtc gaacccaggt gtgcgacgtc agacaacggg ggagtgctcc 10800

ttttggcttc cttccaggcg cggcggctgc tgcgctagct tttttggcca ctggccgcgc 10860 gcagcgtaag cggttaggct ggaaagcgaa agcattaagt ggctcgctcc ctgtagccgg 10920 agggttattt tccaagggtt gagtcgcggg acccccggtt cgagtctcgg accggccgga 10980

ctgcggcgaa cgggggtttg cctccccgtc atgcaagacc ccgcttgcaa attcctccgg 11040 aaacagggac gagccccttt tttgcttttc ccagatgcat ccggtgctgc ggcagatgcg 11100 cccccctcct cagcagcggc aagagcaaga gcagcggcag acatgcaggg caccctcccc 11160

tcctcctacc gcgtcaggag gggcgacatc cgcggttgac gcggcagcag atggtgatta 11220 cgaacccccg cggcgccggg cccggcacta cctggacttg gaggagggcg agggcctggc 11280

gcggctagga gcgccctctc ctgagcggta cccaagggtg cagctgaagc gtgatacgcg 11340 tgaggcgtac gtgccgcggc agaacctgtt tcgcgaccgc gagggagagg agcccgagga 11400 gatgcgggat cgaaagttcc acgcagggcg cgagctgcgg catggcctga atcgcgagcg 11460

gttgctgcgc gaggaggact ttgagcccga cgcgcgaacc gggattagtc ccgcgcgcgc 11520 Page 188

Sequence_Listing.txt acacgtggcg gccgccgacc tggtaaccgc atacgagcag acggtgaacc aggagattaa 11580

ctttcaaaaa agctttaaca accacgtgcg tacgcttgtg gcgcgcgagg aggtggctat 11640 aggactgatg catctgtggg actttgtaag cgcgctggag caaaacccaa atagcaagcc 11700

gctcatggcg cagctgttcc ttatagtgca gcacagcagg gacaacgagg cattcaggga 11760 tgcgctgcta aacatagtag agcccgaggg ccgctggctg ctcgatttga taaacatcct 11820 gcagagcata gtggtgcagg agcgcagctt gagcctggct gacaaggtgg ccgccatcaa 11880

ctattccatg cttagcctgg gcaagtttta cgcccgcaag atataccata ccccttacgt 11940 tcccatagac aaggaggtaa agatcgaggg gttctacatg cgcatggcgc tgaaggtgct 12000 taccttgagc gacgacctgg gcgtttatcg caacgagcgc atccacaagg ccgtgagcgt 12060

gagccggcgg cgcgagctca gcgaccgcga gctgatgcac agcctgcaaa gggccctggc 12120 tggcacgggc agcggcgata gagaggccga gtcctacttt gacgcgggcg ctgacctgcg 12180 ctgggcccca agccgacgcg ccctggaggc agctggggcc ggacctgggc tggcggtggc 12240

acccgcgcgc gctggcaacg tcggcggcgt ggaggaatat gacgaggacg atgagtacga 12300 gccagaggac ggcgagtact aagcggtgat gtttctgatc agatgatgca agacgcaacg 12360

gacccggcgg tgcgggcggc gctgcagagc cagccgtccg gccttaactc cacggacgac 12420

tggcgccagg tcatggaccg catcatgtcg ctgactgcgc gcaatcctga cgcgttccgg 12480

cagcagccgc aggccaaccg gctctccgca attctggaag cggtggtccc ggcgcgcgca 12540

aaccccacgc acgagaaggt gctggcgatc gtaaacgcgc tggccgaaaa cagggccatc 12600 cggcccgacg aggccggcct ggtctacgac gcgctgcttc agcgcgtggc tcgttacaac 12660

agcggcaacg tgcagaccaa cctggaccgg ctggtggggg atgtgcgcga ggccgtggcg 12720

cagcgtgagc gcgcgcagca gcagggcaac ctgggctcca tggttgcact aaacgccttc 12780 ctgagtacac agcccgccaa cgtgccgcgg ggacaggagg actacaccaa ctttgtgagc 12840

gcactgcggc taatggtgac tgagacaccg caaagtgagg tgtaccagtc tgggccagac 12900 tattttttcc agaccagtag acaaggcctg cagaccgtaa acctgagcca ggctttcaaa 12960 aacttgcagg ggctgtgggg ggtgcgggct cccacaggcg accgcgcgac cgtgtctagc 13020

ttgctgacgc ccaactcgcg cctgttgctg ctgctaatag cgcccttcac ggacagtggc 13080 agcgtgtccc gggacacata cctaggtcac ttgctgacac tgtaccgcga ggccataggt 13140 caggcgcatg tggacgagca tactttccag gagattacaa gtgtcagccg cgcgctgggg 13200

caggaggaca cgggcagcct ggaggcaacc ctaaactacc tgctgaccaa ccggcggcag 13260 aagatcccct cgttgcacag tttaaacagc gaggaggagc gcattttgcg ctacgtgcag 13320

cagagcgtga gccttaacct gatgcgcgac ggggtaacgc ccagcgtggc gctggacatg 13380 accgcgcgca acatggaacc gggcatgtat gcctcaaacc ggccgtttat caaccgccta 13440 atggactact tgcatcgcgc ggccgccgtg aaccccgagt atttcaccaa tgccatcttg 13500

aacccgcact ggctaccgcc ccctggtttc tacaccgggg gattcgaggt gcccgagggt 13560 Page 189

Sequence_Listing.txt aacgatggat tcctctggga cgacatagac gacagcgtgt tttccccgca accgcagacc 13620

ctgctagagt tgcaacagcg cgagcaggca gaggcggcgc tgcgaaagga aagcttccgc 13680 aggccaagca gcttgtccga tctaggcgct gcggccccgc ggtcagatgc tagtagccca 13740

tttccaagct tgatagggtc tcttaccagc actcgcacca cccgcccgcg cctgctgggc 13800 gaggaggagt acctaaacaa ctcgctgctg cagccgcagc gcgaaaaaaa cctgcctccg 13860 gcatttccca acaacgggat agagagccta gtggacaaga tgagtagatg gaagacgtac 13920

gcgcaggagc acagggacgt gccaggcccg cgcccgccca cccgtcgtca aaggcacgac 13980 cgtcagcggg gtctggtgtg ggaggacgat gactcggcag acgacagcag cgtcctggat 14040 ttgggaggga gtggcaaccc gtttgcgcac cttcgcccca ggctggggag aatgttttaa 14100

aaaaaaaaaa gcatgatgca aaataaaaaa ctcaccaagg ccatggcacc gagcgttggt 14160 tttcttgtat tccccttagt atgcggcgcg cggcgatgta tgaggaaggt cctcctccct 14220 cctacgagag tgtggtgagc gcggcgccag tggcggcggc gctgggttct cccttcgatg 14280

ctcccctgga cccgccgttt gtgcctccgc ggtacctgcg gcctaccggg gggagaaaca 14340 gcatccgtta ctctgagttg gcacccctat tcgacaccac ccgtgtgtac ctggtggaca 14400

acaagtcaac ggatgtggca tccctgaact accagaacga ccacagcaac tttctgacca 14460

cggtcattca aaacaatgac tacagcccgg gggaggcaag cacacagacc atcaatcttg 14520

acgaccggtc gcactggggc ggcgacctga aaaccatcct gcataccaac atgccaaatg 14580

tgaacgagtt catgtttacc aataagttta aggcgcgggt gatggtgtcg cgcttgccta 14640 ctaaggacaa tcaggtggag ctgaaatacg agtgggtgga gttcacgctg cccgagggca 14700

actactccga gaccatgacc atagacctta tgaacaacgc gatcgtggag cactacttga 14760

aagtgggcag acagaacggg gttctggaaa gcgacatcgg ggtaaagttt gacacccgca 14820 acttcagact ggggtttgac cccgtcactg gtcttgtcat gcctggggta tatacaaacg 14880

aagccttcca tccagacatc attttgctgc caggatgcgg ggtggacttc acccacagcc 14940 gcctgagcaa cttgttgggc atccgcaagc ggcaaccctt ccaggagggc tttaggatca 15000 cctacgatga tctggagggt ggtaacattc ccgcactgtt ggatgtggac gcctaccagg 15060

cgagcttgaa agatgacacc gaacagggcg ggggtggcgc aggcggcagc aacagcagtg 15120 gcagcggcgc ggaagagaac tccaacgcgg cagccgcggc aatgcagccg gtggaggaca 15180 tgaacgatca tgccattcgc ggcgacacct ttgccacacg ggctgaggag aagcgcgctg 15240

aggccgaagc agcggccgaa gctgccgccc ccgctgcgca acccgaggtc gagaagcctc 15300 agaagaaacc ggtgatcaaa cccctgacag aggacagcaa gaaacgcagt tacaacctaa 15360

taagcaatga cagcaccttc acccagtacc gcagctggta ccttgcatac aactacggcg 15420 accctcagac cggaatccgc tcatggaccc tgctttgcac tcctgacgta acctgcggct 15480 cggagcaggt ctactggtcg ttgccagaca tgatgcaaga ccccgtgacc ttccgctcca 15540

cgcgccagat cagcaacttt ccggtggtgg gcgccgagct gttgcccgtg cactccaaga 15600 Page 190

Sequence_Listing.txt gcttctacaa cgaccaggcc gtctactccc aactcatccg ccagtttacc tctctgaccc 15660

acgtgttcaa tcgctttccc gagaaccaga ttttggcgcg cccgccagcc cccaccatca 15720 ccaccgtcag tgaaaacgtt cctgctctca cagatcacgg gacgctaccg ctgcgcaaca 15780

gcatcggagg agtccagcga gtgaccatta ctgacgccag acgccgcacc tgcccctacg 15840 tttacaaggc cctgggcata gtctcgccgc gcgtcctatc gagccgcact ttttgagcaa 15900 gcatgtccat ccttatatcg cccagcaata acacaggctg gggcctgcgc ttcccaagca 15960

agatgtttgg cggggccaag aagcgctccg accaacaccc agtgcgcgtg cgcgggcact 16020 accgcgcgcc ctggggcgcg cacaaacgcg gccgcactgg gcgcaccacc gtcgatgacg 16080 ccatcgacgc ggtggtggag gaggcgcgca actacacgcc cacgccgcca ccagtgtcca 16140

cagtggacgc ggccattcag accgtggtgc gcggagcccg gcgctatgct aaaatgaaga 16200 gacggcggag gcgcgtagca cgtcgccacc gccgccgacc cggcactgcc gcccaacgcg 16260 cggcggcggc cctgcttaac cgcgcacgtc gcaccggccg acgggcggcc atgcgggccg 16320

ctcgaaggct ggccgcgggt attgtcactg tgccccccag gtccaggcga cgagcggccg 16380 ccgcagcagc cgcggccatt agtgctatga ctcagggtcg caggggcaac gtgtattggg 16440

tgcgcgactc ggttagcggc ctgcgcgtgc ccgtgcgcac ccgccccccg cgcaactaga 16500

ttgcaagaaa aaactactta gactcgtact gttgtatgta tccagcggcg gcggcgcgca 16560

acgaagctat gtccaagcgc aaaatcaaag aagagatgct ccaggtcatc gcgccggaga 16620

tctatggccc cccgaagaag gaagagcagg attacaagcc ccgaaagcta aagcgggtca 16680 aaaagaaaaa gaaagatgat gatgatgaac ttgacgacga ggtggaactg ctgcacgcta 16740

ccgcgcccag gcgacgggta cagtggaaag gtcgacgcgt aaaacgtgtt ttgcgacccg 16800

gcaccaccgt agtctttacg cccggtgagc gctccacccg cacctacaag cgcgtgtatg 16860 atgaggtgta cggcgacgag gacctgcttg agcaggccaa cgagcgcctc ggggagtttg 16920

cctacggaaa gcggcataag gacatgctgg cgttgccgct ggacgagggc aacccaacac 16980 ctagcctaaa gcccgtaaca ctgcagcagg tgctgcccgc gcttgcaccg tccgaagaaa 17040 agcgcggcct aaagcgcgag tctggtgact tggcacccac cgtgcagctg atggtaccca 17100

agcgccagcg actggaagat gtcttggaaa aaatgaccgt ggaacctggg ctggagcccg 17160 aggtccgcgt gcggccaatc aagcaggtgg cgccgggact gggcgtgcag accgtggacg 17220 ttcagatacc cactaccagt agcaccagta ttgccaccgc cacagagggc atggagacac 17280

aaacgtcccc ggttgcctca gcggtggcgg atgccgcggt gcaggcggtc gctgcggccg 17340 cgtccaagac ctctacggag gtgcaaacgg acccgtggat gtttcgcgtt tcagcccccc 17400

ggcgcccgcg cggttcgagg aagtacggcg ccgccagcgc gctactgccc gaatatgccc 17460 tacatccttc cattgcgcct acccccggct atcgtggcta cacctaccgc cccagaagac 17520 gagcaactac ccgacgccga accaccactg gaacccgccg ccgccgtcgc cgtcgccagc 17580

ccgtgctggc cccgatttcc gtgcgcaggg tggctcgcga aggaggcagg accctggtgc 17640 Page 191

Sequence_Listing.txt tgccaacagc gcgctaccac cccagcatcg tttaaaagcc ggtctttgtg gttcttgcag 17700

atatggccct cacctgccgc ctccgtttcc cggtgccggg attccgagga agaatgcacc 17760 gtaggagggg catggccggc cacggcctga cgggcggcat gcgtcgtgcg caccaccggc 17820

ggcggcgcgc gtcgcaccgt cgcatgcgcg gcggtatcct gcccctcctt attccactga 17880 tcgccgcggc gattggcgcc gtgcccggaa ttgcatccgt ggccttgcag gcgcagagac 17940 actgattaaa aacaagttgc atgtggaaaa atcaaaataa aaagtctgga ctctcacgct 18000

cgcttggtcc tgtaactatt ttgtagaatg gaagacatca actttgcgtc tctggccccg 18060 cgacacggct cgcgcccgtt catgggaaac tggcaagata tcggcaccag caatatgagc 18120 ggtggcgcct tcagctgggg ctcgctgtgg agcggcatta aaaatttcgg ttccaccgtt 18180

aagaactatg gcagcaaggc ctggaacagc agcacaggcc agatgctgag ggataagttg 18240 aaagagcaaa atttccaaca aaaggtggta gatggcctgg cctctggcat tagcggggtg 18300 gtggacctgg ccaaccaggc agtgcaaaat aagattaaca gtaagcttga tccccgccct 18360

cccgtagagg agcctccacc ggccgtggag acagtgtctc cagaggggcg tggcgaaaag 18420 cgtccgcgcc ccgacaggga agaaactctg gtgacgcaaa tagacgagcc tccctcgtac 18480

gaggaggcac taaagcaagg cctgcccacc acccgtccca tcgcgcccat ggctaccgga 18540

gtgctgggcc agcacacacc cgtaacgctg gacctgcctc cccccgccga cacccagcag 18600

aaacctgtgc tgccaggccc gaccgccgtt gttgtaaccc gtcctagccg cgcgtccctg 18660

cgccgcgccg ccagcggtcc gcgatcgttg cggcccgtag ccagtggcaa ctggcaaagc 18720 acactgaaca gcatcgtggg tctgggggtg caatccctga agcgccgacg atgcttctga 18780

atagctaacg tgtcgtatgt gtgtcatgta tgcgtccatg tcgccgccag aggagctgct 18840

gagccgccgc gcgcccgctt tccaagatgg ctaccccttc gatgatgccg cagtggtctt 18900 acatgcacat ctcgggccag gacgcctcgg agtacctgag ccccgggctg gtgcagtttg 18960

cccgcgccac cgagacgtac ttcagcctga ataacaagtt tagaaacccc acggtggcgc 19020 ctacgcacga cgtgaccaca gaccggtccc agcgtttgac gctgcggttc atccctgtgg 19080 accgtgagga tactgcgtac tcgtacaagg cgcggttcac cctagctgtg ggtgataacc 19140

gtgtgctgga catggcttcc acgtactttg acatccgcgg cgtgctggac aggggcccta 19200 cttttaagcc ctactctggc actgcctaca acgccctggc tcccaagggt gccccaaatc 19260 cttgcgaatg ggatgaagct gctactgctc ttgaaataaa cctagaagaa gaggacgatg 19320

acaacgaaga cgaagtagac gagcaagctg agcagcaaaa aactcacgta tttgggcagg 19380 cgccttattc tggtataaat attacaaagg agggtattca aataggtgtc gaaggtcaaa 19440

cacctaaata tgccgataaa acatttcaac ctgaacctca aataggagaa tctcagtggt 19500 acgaaactga aattaatcat gcagctggga gagtccttaa aaagactacc ccaatgaaac 19560 catgttacgg ttcatatgca aaacccacaa atgaaaatgg agggcaaggc attcttgtaa 19620

agcaacaaaa tggaaagcta gaaagtcaag tggaaatgca atttttctca actactgagg 19680 Page 192

Sequence_Listing.txt cgaccgcagg caatggtgat aacttgactc ctaaagtggt attgtacagt gaagatgtag 19740

atatagaaac cccagacact catatttctt acatgcccac tattaaggaa ggtaactcac 19800 gagaactaat gggccaacaa tctatgccca acaggcctaa ttacattgct tttagggaca 19860

attttattgg tctaatgtat tacaacagca cgggtaatat gggtgttctg gcgggccaag 19920 catcgcagtt gaatgctgtt gtagatttgc aagacagaaa cacagagctt tcataccagc 19980 ttttgcttga ttccattggt gatagaacca ggtacttttc tatgtggaat caggctgttg 20040

acagctatga tccagatgtt agaattattg aaaatcatgg aactgaagat gaacttccaa 20100 attactgctt tccactggga ggtgtgatta atacagagac tcttaccaag gtaaaaccta 20160 aaacaggtca ggaaaatgga tgggaaaaag atgctacaga attttcagat aaaaatgaaa 20220

taagagttgg aaataatttt gccatggaaa tcaatctaaa tgccaacctg tggagaaatt 20280 tcctgtactc caacatagcg ctgtatttgc ccgacaagct aaagtacagt ccttccaacg 20340 taaaaatttc tgataaccca aacacctacg actacatgaa caagcgagtg gtggctcccg 20400

ggttagtgga ctgctacatt aaccttggag cacgctggtc ccttgactat atggacaacg 20460 tcaacccatt taaccaccac cgcaatgctg gcctgcgcta ccgctcaatg ttgctgggca 20520

atggtcgcta tgtgcccttc cacatccagg tgcctcagaa gttctttgcc attaaaaacc 20580

tccttctcct gccgggctca tacacctacg agtggaactt caggaaggat gttaacatgg 20640

ttctgcagag ctccctagga aatgacctaa gggttgacgg agccagcatt aagtttgata 20700

gcatttgcct ttacgccacc ttcttcccca tggcccacaa caccgcctcc acgcttgagg 20760 ccatgcttag aaacgacacc aacgaccagt cctttaacga ctatctctcc gccgccaaca 20820

tgctctaccc tatacccgcc aacgctacca acgtgcccat atccatcccc tcccgcaact 20880

gggcggcttt ccgcggctgg gccttcacgc gccttaagac taaggaaacc ccatcactgg 20940 gctcgggcta cgacccttat tacacctact ctggctctat accctaccta gatggaacct 21000

tttacctcaa ccacaccttt aagaaggtgg ccattacctt tgactcttct gtcagctggc 21060 ctggcaatga ccgcctgctt acccccaacg agtttgaaat taagcgctca gttgacgggg 21120 agggttacaa cgttgcccag tgtaacatga ccaaagactg gttcctggta caaatgctag 21180

ctaactacaa cattggctac cagggcttct atatcccaga gagctacaag gaccgcatgt 21240 actccttctt tagaaacttc cagcccatga gccgtcaggt ggtggatgat actaaataca 21300 aggactacca acaggtgggc atcctacacc aacacaacaa ctctggattt gttggctacc 21360

ttgcccccac catgcgcgaa ggacaggcct accctgctaa cttcccctat ccgcttatag 21420 gcaagaccgc agttgacagc attacccaga aaaagtttct ttgcgatcgc accctttggc 21480

gcatcccatt ctccagtaac tttatgtcca tgggcgcact cacagacctg ggccaaaacc 21540 ttctctacgc caactccgcc cacgcgctag acatgacttt tgaggtggat cccatggacg 21600 agcccaccct tctttatgtt ttgtttgaag tctttgacgt ggtccgtgtg caccggccgc 21660

accgcggcgt catcgaaacc gtgtacctgc gcacgccctt ctcggccggc aacgccacaa 21720 Page 193

Sequence_Listing.txt cataaagaag caagcaacat caacaacagc tgccgccatg ggctccagtg agcaggaact 21780

gaaagccatt gtcaaagatc ttggttgtgg gccatatttt ttgggcacct atgacaagcg 21840 ctttccaggc tttgtttctc cacacaagct cgcctgcgcc atagtcaata cggccggtcg 21900

cgagactggg ggcgtacact ggatggcctt tgcctggaac ccgcactcaa aaacatgcta 21960 cctctttgag ccctttggct tttctgacca gcgactcaag caggtttacc agtttgagta 22020 cgagtcactc ctgcgccgta gcgccattgc ttcttccccc gaccgctgta taacgctgga 22080

aaagtccacc caaagcgtac aggggcccaa ctcggccgcc tgtggactat tctgctgcat 22140 gtttctccac gcctttgcca actggcccca aactcccatg gatcacaacc ccaccatgaa 22200 ccttattacc ggggtaccca actccatgct caacagtccc caggtacagc ccaccctgcg 22260

tcgcaaccag gaacagctct acagcttcct ggagcgccac tcgccctact tccgcagcca 22320 cagtgcgcag attaggagcg ccacttcttt ttgtcacttg aaaaacatgt aaaaataatg 22380 tactagagac actttcaata aaggcaaatg cttttatttg tacactctcg ggtgattatt 22440

tacccccacc cttgccgtct gcgccgttta aaaatcaaag gggttctgcc gcgcatcgct 22500 atgcgccact ggcagggaca cgttgcgata ctggtgttta gtgctccact taaactcagg 22560

cacaaccatc cgcggcagct cggtgaagtt ttcactccac aggctgcgca ccatcaccaa 22620

cgcgtttagc aggtcgggcg ccgatatctt gaagtcgcag ttggggcctc cgccctgcgc 22680

gcgcgagttg cgatacacag ggttgcagca ctggaacact atcagcgccg ggtggtgcac 22740

gctggccagc acgctcttgt cggagatcag atccgcgtcc aggtcctccg cgttgctcag 22800 ggcgaacgga gtcaactttg gtagctgcct tcccaaaaag ggcgcgtgcc caggctttga 22860

gttgcactcg caccgtagtg gcatcaaaag gtgaccgtgc ccggtctggg cgttaggata 22920

cagcgcctgc ataaaagcct tgatctgctt aaaagccacc tgagcctttg cgccttcaga 22980 gaagaacatg ccgcaagact tgccggaaaa ctgattggcc ggacaggccg cgtcgtgcac 23040

gcagcacctt gcgtcggtgt tggagatctg caccacattt cggccccacc ggttcttcac 23100 gatcttggcc ttgctagact gctccttcag cgcgcgctgc ccgttttcgc tcgtcacatc 23160 catttcaatc acgtgctcct tatttatcat aatgcttccg tgtagacact taagctcgcc 23220

ttcgatctca gcgcagcggt gcagccacaa cgcgcagccc gtgggctcgt gatgcttgta 23280 ggtcacctct gcaaacgact gcaggtacgc ctgcaggaat cgccccatca tcgtcacaaa 23340 ggtcttgttg ctggtgaagg tcagctgcaa cccgcggtgc tcctcgttca gccaggtctt 23400

gcatacggcc gccagagctt ccacttggtc aggcagtagt ttgaagttcg cctttagatc 23460 gttatccacg tggtacttgt ccatcagcgc gcgcgcagcc tccatgccct tctcccacgc 23520

agacacgatc ggcacactca gcgggttcat caccgtaatt tcactttccg cttcgctggg 23580 ctcttcctct tcctcttgcg tccgcatacc acgcgccact gggtcgtctt cattcagccg 23640 ccgcactgtg cgcttacctc ctttgccatg cttgattagc accggtgggt tgctgaaacc 23700

caccatttgt agcgccacat cttctctttc ttcctcgctg tccacgatta cctctggtga 23760 Page 194

Sequence_Listing.txt tggcgggcgc tcgggcttgg gagaagggcg cttctttttc ttcttgggcg caatggccaa 23820

atccgccgcc gaggtcgatg gccgcgggct gggtgtgcgc ggcaccagcg cgtcttgtga 23880 tgagtcttcc tcgtcctcgg actcgatacg ccgcctcatc cgcttttttg ggggcgcccg 23940

gggaggcggc ggcgacgggg acggggacga cacgtcctcc atggttgggg gacgtcgcgc 24000 cgcaccgcgt ccgcgctcgg gggtggtttc gcgctgctcc tcttcccgac tggccatttc 24060 cttctcctat aggcagaaaa agatcatgga gtcagtcgag aagaaggaca gcctaaccgc 24120

cccctctgag ttcgccacca ccgcctccac cgatgccgcc aacgcgccta ccaccttccc 24180 cgtcgaggca cccccgcttg aggaggagga agtgattatc gagcaggacc caggttttgt 24240 aagcgaagac gacgaggacc gctcagtacc aacagaggat aaaaagcaag accaggacaa 24300

cgcagaggca aacgaggaac aagtcgggcg gggggacgaa aggcatggcg actacctaga 24360 tgtgggagac gacgtgctgt tgaagcatct gcagcgccag tgcgccatta tctgcgacgc 24420 gttgcaagag cgcagcgatg tgcccctcgc catagcggat gtcagccttg cctacgaacg 24480

ccacctattc tcaccgcgcg taccccccaa acgccaagaa aacggcacat gcgagcccaa 24540 cccgcgcctc aacttctacc ccgtatttgc cgtgccagag gtgcttgcca cctatcacat 24600

ctttttccaa aactgcaaga tacccctatc ctgccgtgcc aaccgcagcc gagcggacaa 24660

gcagctggcc ttgcggcagg gcgctgtcat acctgatatc gcctcgctca acgaagtgcc 24720

aaaaatcttt gagggtcttg gacgcgacga gaagcgcgcg gcaaacgctc tgcaacagga 24780

aaacagcgaa aatgaaagtc actctggagt gttggtggaa ctcgagggtg acaacgcgcg 24840 cctagccgta ctaaaacgca gcatcgaggt cacccacttt gcctacccgg cacttaacct 24900

accccccaag gtcatgagca cagtcatgag tgagctgatc gtgcgccgtg cgcagcccct 24960

ggagagggat gcaaatttgc aagaacaaac agaggagggc ctacccgcag ttggcgacga 25020 gcagctagcg cgctggcttc aaacgcgcga gcctgccgac ttggaggagc gacgcaaact 25080

aatgatggcc gcagtgctcg ttaccgtgga gcttgagtgc atgcagcggt tctttgctga 25140 cccggagatg cagcgcaagc tagaggaaac attgcactac acctttcgac agggctacgt 25200 acgccaggcc tgcaagatct ccaacgtgga gctctgcaac ctggtctcct accttggaat 25260

tttgcacgaa aaccgccttg ggcaaaacgt gcttcattcc acgctcaagg gcgaggcgcg 25320 ccgcgactac gtccgcgact gcgtttactt atttctatgc tacacctggc agacggccat 25380 gggcgtttgg cagcagtgct tggaggagtg caacctcaag gagctgcaga aactgctaaa 25440

gcaaaacttg aaggacctat ggacggcctt caacgagcgc tccgtggccg cgcacctggc 25500 ggacatcatt ttccccgaac gcctgcttaa aaccctgcaa cagggtctgc cagacttcac 25560

cagtcaaagc atgttgcaga actttaggaa ctttatccta gagcgctcag gaatcttgcc 25620 cgccacctgc tgtgcacttc ctagcgactt tgtgcccatt aagtaccgcg aatgccctcc 25680 gccgctttgg ggccactgct accttctgca gctagccaac taccttgcct accactctga 25740

cataatggaa gacgtgagcg gtgacggtct actggagtgt cactgtcgct gcaacctatg 25800 Page 195

Sequence_Listing.txt caccccgcac cgctccctgg tttgcaattc gcagctgctt aacgaaagtc aaattatcgg 25860

tacctttgag ctgcagggtc cctcgcctga cgaaaagtcc gcggctccgg ggttgaaact 25920 cactccgggg ctgtggacgt cggcttacct tcgcaaattt gtacctgagg actaccacgc 25980

ccacgagatt aggttctacg aagaccaatc ccgcccgcca aatgcggagc ttaccgcctg 26040 cgtcattacc cagggccaca ttcttggcca attgcaagcc atcaacaaag cccgccaaga 26100 gtttctgcta cgaaagggac ggggggttta cttggacccc cagtccggcg aggagctcaa 26160

cccaatcccc ccgccgccgc agccctatca gcagcagccg cgggcccttg cttcccagga 26220 tggcacccaa aaagaagctg cagctgccgc cgccacccac ggacgaggag gaatactggg 26280 acagtcaggc agaggaggtt ttggacgagg aggaggagga catgatggaa gactgggaga 26340

gcctagacga ggaagcttcc gaggtcgaag aggtgtcaga cgaaacaccg tcaccctcgg 26400 tcgcattccc ctcgccggcg ccccagaaat cggcaaccgg ttccagcatg gctacaacct 26460 ccgctcctca ggcgccgccg gcactgcccg ttcgccgacc caaccgtaga tgggacacca 26520

ctggaaccag ggccggtaag tccaagcagc cgccgccgtt agcccaagag caacaacagc 26580 gccaaggcta ccgctcatgg cgcgggcaca agaacgccat agttgcttgc ttgcaagact 26640

gtgggggcaa catctccttc gcccgccgct ttcttctcta ccatcacggc gtggccttcc 26700

cccgtaacat cctgcattac taccgtcatc tctacagccc atactgcacc ggcggcagcg 26760

gcagcggcag caacagcagc ggccacacag aagcaaaggc gaccggatag caagactctg 26820

acaaagccca agaaatccac agcggcggca gcagcaggag gaggagcgct gcgtctggcg 26880 cccaacgaac ccgtatcgac ccgcgagctt agaaacagga tttttcccac tctgtatgct 26940

atatttcaac agagcagggg ccaagaacaa gagctgaaaa taaaaaacag gtctctgcga 27000

tccctcaccc gcagctgcct gtatcacaaa agcgaagatc agcttcggcg cacgctggaa 27060 gacgcggagg ctctcttcag taaatactgc gcgctgactc ttaaggacta gtttcgcgcc 27120

ctttctcaaa tttaagcgcg aaaactacgt catctccagc ggccacaccc ggcgccagca 27180 cctgtcgtca gcgccatttc aactttgtat acaaaagttg tgatgagcaa ggaaattccc 27240 acgccctaca tgtggagtta ccagccacaa atgggacttg cggctggagc tgcccaagac 27300

tactcaaccc gaataaacta catgagcgcg ggaccccaca tgatatcccg ggtcaacgga 27360 atacgcgccc accgaaaccg aattctcctg gaacaggcgg ctattaccac cacacctcgt 27420 aataacctta atccccgtag ttggcccgct gccctggtgt accaggaaag tcccgctccc 27480

accactgtgg tacttcccag agacgcccag gccgaagttc agatgactaa ctcaggggcg 27540 cagcttgcgg gcggctttcg tcacagggtg cggtcgcccg ggcagggtat aactcacctg 27600

acaatcagag ggcgaggtat tcagctcaac gacgagtcgg tgagctcctc gcttggtctc 27660 cgtccggacg ggacatttca gatcggcggc gccggccgct cttcattcac gcctcgtcag 27720 gcaatcctaa ctctgcagac ctcgtcctct gagccgcgct ctggaggcat tggaactctg 27780

caatttattg aggagtttgt gccatcggtc tactttaacc ccttctcggg acctcccggc 27840 Page 196

Sequence_Listing.txt cactatccgg atcaatttat tcctaacttt gacgcggtaa aggactcggc ggacggctac 27900

gactgaatgt taagtggaga ggcagagcaa ctgcgcctga aacacctggt ccactgtcgc 27960 cgccacaagt gctttgcccg cgactccggt gagttttgct actttgaatt gcccgaggat 28020

catatcgagg gcccggcgca cggcgtccgg cttaccgccc agggagagct tgcccgtagc 28080 ctgattcggg agtttaccca gcgccccctg ctagttgagc gggacagggg accctgtgtt 28140 ctcactgtga tttgcaactg tcctaaccct ggattacatc aagatctttg ttgccatctc 28200

tgtgctgagt ataataaata cagaaattaa aatatactgg ggctcctatc gccatcctgt 28260 aaacgccacc gtcttcaccc gcccaagcaa accaaggcga accttacctg gtacttttaa 28320 catctctccc tctgtgattt acaacagttt caacccagac ggagtgagtc tacgagagaa 28380

cctctccgag ctcagctact ccatcagaaa aaacaccacc ctccttacct gccgggaacg 28440 tacgagtgcg tcaccggccg ctgcaccaca cctaccgcct gaccgtaaac cagacttttt 28500 ccggacagac ctcaataact ctgtttacca gaacaggagg tgagcttaga aaacccttag 28560

ggtattaggc caaaggcgca gctactgtgg ggtttatgaa caattcaagc aactctacgg 28620 gctattctaa ttcaggtttc tctagaatcg gggttggggt tattctctgt cttgtgattc 28680

tctttattct tatactaacg cttctctgcc taaggctcgc cgcctgctgt gtgcacattt 28740

gcatttattg tcagcttttt aaacgctggg gtcgccaccc aagatgatta ggtacataat 28800

cctaggttta ctcacccttg cgtcagccca cggtaccacc caaaaggtgg attttaagga 28860

gccagcctgt aatgttacat tcgcagctga agctaatgag tgcaccactc ttataaaatg 28920 caccacagaa catgaaaagc tgcttattcg ccacaaaaac aaaattggca agtatgctgt 28980

ttatgctatt tggcagccag gtgacactac agagtataat gttacagttt tccagggtaa 29040

aagtcataaa acttttatgt atacttttcc attttatgaa atgtgcgaca ttaccatgta 29100 catgagcaaa cagtataagt tgtggccccc acaaaattgt gtggaaaaca ctggcacttt 29160

ctgctgcact gctatgctaa ttacagtgct cgctttggtc tgtaccctac tctatattaa 29220 atacaaaagc agacgcagct ttattgagga aaagaaaatg ccttaattta ctaagttaca 29280 aagctaatgt caccactaac tgctttactc gctgcttgca aaacaaattc aaaaagttag 29340

cattataatt agaataggat ttaaaccccc cggtcatttc ctgctcaata ccattcccct 29400 gaacaattga ctctatgtgg gatatgctcc agcgctacaa ccttgaagtc aggcttcctg 29460 gatgtcagca tctgactttg gccagcacct gtcccgcgga tttgttccag tccaactaca 29520

gcgacccacc ctaacagaga tgaccaacac aaccaacgcg gccgccgcta ccggacttac 29580 atctaccaca aatacacccc aagtttctgc ctttgtcaat aactgggata acttgggcat 29640

gtggtggttc tccatagcgc ttatgtttgt atgccttatt attatgtggc tcatctgctg 29700 cctaaagcgc aaacgcgccc gaccacccat ctatagtccc atcattgtgc tacacccaaa 29760 caatgatgga atccatagat tggacggact gaaacacatg ttcttttctc ttacagtatg 29820

attaaatgag acatgattcc tcgagttttt atattactga cccttgttgc gcttttttgt 29880 Page 197

Sequence_Listing.txt gcgtgctcca cattggctgc ggtttctcac atcgaagtag actgcattcc agccttcaca 29940

gtctatttgc tttacggatt tgtcaccctc acgctcatct gcagcctcat cactgtggtc 30000 atcgccttta tccagtgcat tgactgggtc tgtgtgcgct ttgcatatct cagacaccat 30060

ccccagtaca gggacaggac tatagctgag cttcttagaa ttctttaatt atgaaattta 30120 ctgtgacttt tctgctgatt atttgcaccc tatctgcgtt ttgttccccg acctccaagc 30180 ctcaaagaca tatatcatgc agattcactc gtatatggaa tattccaagt tgctacaatg 30240

aaaaaagcga tctttccgaa gcctggttat atgcaatcat ctctgttatg gtgttctgca 30300 gtaccatctt agccctagct atatatccct accttgacat tggctggaac gcaatagatg 30360 ccatgaacca cccaactttc cccgcgcccg ctatgcttcc actgcaacaa gttgttgccg 30420

gcggctttgt cccagccaat cagcctcgcc caccttctcc cacccccact gaaatcagct 30480 actttaatct aacaggagga gatgactgac accctagatc tagaaatgga cggaattatt 30540 acagagcagc gcctgctaga aagacgcagg gcagcggccg agcaacagcg catgaatcaa 30600

gagctccaag acatggttaa cttgcaccag tgcaaaaggg gtatcttttg tctggtaaag 30660 caggccaaag tcacctacga cagtaatacc accggacacc gccttagcta caagttgcca 30720

accaagcgtc agaaattggt ggtcatggtg ggagaaaagc ccattaccat aactcagcac 30780

tcggtagaaa ccgaaggctg cattcactca ccttgtcaag gacctgagga tctctgcacc 30840

cttattaaga ccctgtgcgg tctcaaagat cttattccct ttaactaata aaaaaaaata 30900

ataaagcatc acttacttaa aatcagttag caaatttctg tccagtttat tcagcagcac 30960 ctccttgccc tcctcccagc tctggtattg cagcttcctc ctggctgcaa actttctcca 31020

caatctaaat ggaatgtcag tttcctcctg ttcctgtcca tccgcaccca ctatcttcat 31080

gttgttgcag atgaagcgcg caagaccgtc tgaagatacc ttcaaccccg tgtatccata 31140 tgacacggaa accggtcctc caactgtgcc ttttcttact cctccctttg tatcccccaa 31200

tgggtttcaa gagagtcccc ctggggtact ctctttgcgc ctatccgaac ctctagttac 31260 ctccaatggc atgcttgcgc tcaaaatggg caacggcctc tctctggacg aggccggcaa 31320 ccttacctcc caaaatgtaa ccactgtgag cccacctctc aaaaaaacca agtcaaacat 31380

aaacctggaa atatctgcac ccctcacagt tacctcagaa gccctaactg tggctgccgc 31440 cgcacctcta atggtcgcgg gcaacacact caccatgcaa tcacaggccc cgctaaccgt 31500 gcacgactcc aaacttagca ttgccaccca aggacccctc acagtgtcag aaggaaagct 31560

agccctgcaa acatcaggcc ccctcaccac caccgatagc agtaccctta ctatcactgc 31620 ctcaccccct ctaactactg ccactggtag cttgggcatt gacttgaaag agcccattta 31680

tacacaaaat ggaaaactag gactaaagta cggggctcct ttgcatgtaa cagacgacct 31740 aaacactttg accgtagcaa ctggtccagg tgtgactatt aataatactt ccttgcaaac 31800 taaagttact ggagccttgg gttttgattc acaaggcaat atgcaactta atgtagcagg 31860

aggactaagg attgattctc aaaacagacg ccttatactt gatgttagtt atccgtttga 31920 Page 198

Sequence_Listing.txt tgctcaaaac caactaaatc taagactagg acagggccct ctttttataa actcagccca 31980

caacttggat attaactaca acaaaggcct ttacttgttt acagcttcaa acaattccaa 32040 aaagcttgag gttaacctaa gcactgccaa ggggttgatg tttgacgcta cagccatagc 32100

cattaatgca ggagatgggc ttgaatttgg ttcacctaat gcaccaaaca caaatcccct 32160 caaaacaaaa attggccatg gcctagaatt tgattcaaac aaggctatgg ttcctaaact 32220 aggaactggc cttagttttg acagcacagg tgccattaca gtaggaaaca aaaataatga 32280

taagctaact ttgtggacca caccagctcc atctcctaac tgtagactaa atgcagagaa 32340 agatgctaaa ctcactttgg tcttaacaaa atgtggcagt caaatacttg ctacagtttc 32400 agttttggct gttaaaggca gtttggctcc aatatctgga acagttcaaa gtgctcatct 32460

tattataaga tttgacgaaa atggagtgct actaaacaat tccttcctgg acccagaata 32520 ttggaacttt agaaatggag atcttactga aggcacagcc tatacaaacg ctgttggatt 32580 tatgcctaac ctatcagctt atccaaaatc tcacggtaaa actgccaaaa gtaacattgt 32640

cagtcaagtt tacttaaacg gagacaaaac taaacctgta acactaacca ttacactaaa 32700 cggtacacag gaaacaggag acacaactcc aagtgcatac tctatgtcat tttcatggga 32760

ctggtctggc cacaactaca ttaatgaaat atttgccaca tcctcttaca ctttttcata 32820

cattgcccaa gaataaagaa tcgtttgtgt tatgtttcaa cgtgtttatt tttcaattgc 32880

agaaaatttc aagtcatttt tcattcagta gtatagcccc accaccacat agcttataca 32940

gatcaccgta cctcaacttt gtataataaa gttgaatcaa actcacagaa ccctagtatt 33000 caacctgcca cctccctccc aacacacaga gtacacagtc ctttctcccc ggctggcctt 33060

aaaaagcatc atatcatggg taacagacat attcttaggt gttatattcc acacggtttc 33120

ctgtcgagcc aaacgctcat cagtgatatt aataaactcc ccgggcagct cacttaagtt 33180 catgtcgctg tccagctgct gagccacagg ctgctgtcca acttgcggtt gcttaacggg 33240

cggcgaagga gaagtccacg cctacatggg ggtagagtca taatcgtgca tcaggatagg 33300 gcggtggtgc tgcagcagcg cgcgaataaa ctgctgccgc cgccgctccg tcctgcagga 33360 atacaacatg gcagtggtct cctcagcgat gattcgcacc gcccgcagca taaggcgcct 33420

tgtcctccgg gcacagcagc gcaccctgat ctcacttaaa tcagcacagt aactgcagca 33480 cagcaccaca atattgttca aaatcccaca gtgcaaggcg ctgtatccaa agctcatggc 33540 ggggaccaca gaacccacgt ggccatcata ccacaagcgc aggtagatta agtggcgacc 33600

cctcataaac acgctggaca taaacattac ctcttttggc atgttgtaat tcaccacctc 33660 ccggtaccat ataaacctct gattaaacat ggcgccatcc accaccatcc taaaccagct 33720

ggccaaaacc tgcccgccgg ctatacactg cagggaaccg ggactggaac aatgacagtg 33780 gagagcccag gactcgtaac catggatcat catgctcgtc atgatatcaa tgttggcaca 33840 acacaggcac acgtgcatac acttcctcag gattacaagc tcctcccgcg ttagaaccat 33900

atcccaggga acaacccatt cctgaatcag cgtaaatccc acactgcagg gaagacctcg 33960 Page 199

Sequence_Listing.txt cacgtaactc acgttgtgca ttgtcaaagt gttacattcg ggcagcagcg gatgatcctc 34020

cagtatggta gcgcgggttt ctgtctcaaa aggaggtaga cgatccctac tgtacggagt 34080 gcgccgagac aaccgagatc gtgttggtcg tagtgtcatg ccaaatggaa cgccggacgt 34140

agtcatattt cctgaagcaa aaccaggtgc gggcgtgaca aacagatctg cgtctccggt 34200 ctcgccgctt agatcgctct gtgtagtagt tgtagtatat ccactctctc aaagcatcca 34260 ggcgccccct ggcttcgggt tctatgtaaa ctccttcatg cgccgctgcc ctgataacat 34320

ccaccaccgc agaataagcc acacccagcc aacctacaca ttcgttctgc gagtcacaca 34380 cgggaggagc gggaagagct ggaagaacca tgtttttttt tttattccaa aagattatcc 34440 aaaacctcaa aatgaagatc tattaagtga acgcgctccc ctccggtggc gtggtcaaac 34500

tctacagcca aagaacagat aatggcattt gtaagatgtt gcacaatggc ttccaaaagg 34560 caaacggccc tcacgtccaa gtggacgtaa aggctaaacc cttcagggtg aatctcctct 34620 ataaacattc cagcaccttc aaccatgccc aaataattct catctcgcca ccttctcaat 34680

atatctctaa gcaaatcccg aatattaagt ccggccattg taaaaatctg ctccagagcg 34740 ccctccacct tcagcctcaa gcagcgaatc atgattgcaa aaattcaggt tcctcacaga 34800

cctgtataag attcaaaagc ggaacattaa caaaaatacc gcgatcccgt aggtcccttc 34860

gcagggccag ctgaacataa tcgtgcaggt ctgcacggac cagcgcggcc acttccccgc 34920

caggaaccat gacaaaagaa cccacactga ttatgacacg catactcgga gctatgctaa 34980

ccagcgtagc cccgatgtaa gcttgttgca tgggcggcga tataaaatgc aaggtgctgc 35040 tcaaaaaatc aggcaaagcc tcgcgcaaaa aagaaagcac atcgtagtca tgctcatgca 35100

gataaaggca ggtaagctcc ggaaccacca cagaaaaaga caccattttt ctctcaaaca 35160

ttgggccagg attctcctcg acgtcaccag cctgcttcag caggctgaag ttagtagctc 35220 cgcttccctt gtacagctcg tccatgccgc cggtggagtg gcggccctcg gcgcgttcgt 35280

actgttccac gatggtgtag tcctcgttgt gggaggtgat gtccaacttg atgttgacgt 35340 tgtaggcgcc gggcagctgc acgggcttct tggccttgta ggtggtcttg acctcagcgt 35400 cgtagtggcc gccgtccttc agcttcagcc tctgcttgat ctcgcccttc agggcgccgt 35460

cctcggggta catccgctcg gaggaggcct cccagcccat ggtcttcttc tgcattacgg 35520 ggccgtcgga ggggaagttg gtgccgcgca gcttcacctt gtagatgaac tcgccgtcct 35580 gcagggagga gtcctgggtc acggtcacca cgccgccgtc ctcgaagttc atcacgcgct 35640

cccacttgaa gccctcgggg aaggacagct tcaagtagtc ggggatgtcg gcggggtgct 35700 tcacgtaggc cttggagccg tacatgaact gaggggacag gatgtcccag gcgaagggca 35760

gggggccacc cttggtcacc ttcagcttgg cggtctgggt gccctcgtag gggcggccct 35820 cgccctcgcc ctcgatctcg aactcgtggc cgttcacgga gccctccatg tgcaccttga 35880 agcgcatgaa ctccttgatg atggccatgt tatcctcctc gcccttgctc accatgtctg 35940

cgggtttctg cataaacaca aaataaaata acaaaaaaac atttaaacat tagaagcctg 36000 Page 200

Sequence_Listing.txt tcttacaaca ggaaaaacaa cccttataag cataagacgg actacggcca tgccggcgtg 36060

accgtaaaaa aactggtcac cgtgattaaa aagcaccacc gacagctcct cggtcatgtc 36120 cggagtcata atgtaagact cggtaaacac atcaggttga ttcacatcgg tcagtgctaa 36180

aaagcgaccg aaatagcccg ggggaataca tacccgcagg cgtagagaca acattacagc 36240 ccccatagga ggtataacaa aattaatagg agagaaaaac acataaacac ctgaaaaacc 36300 ctcctgccta ggcaaaatag caccctcccg ctccagaaca acatacagcg cttccacagc 36360

ggcagccata acagtcagcc ttaccagtaa aaaagaaaac ctattaaaaa aacaccactc 36420 gacacggcac cagctcaatc agtcacagtg taaaaaaggg ccaagtgcag agcgagtata 36480 tataggacta aaaaatgacg taacggttaa agtccacaaa aaacacccag aaaaccgcac 36540

gcgaacctac gcccagaaac gaaagccaaa aaacccacaa cttcctcaaa tcgtcacttc 36600 cgttttccca cgttacgtca cttcccattt taagaaaact acaattccca acacatacaa 36660 gttactccgc cctaaaacct acgtcacccg ccccgttccc acgccccgcg ccacgtcaca 36720

aactccaccc cctcattatc atattggctt caatccaaaa taaggtatat tattgatgat 36780 g 36781

<210> 12 <211> 36899 <212> DNA <213> Artificial Sequence

<220> <223> Synthetic adenovirus genome YPet-P2A-Fiber

<400> 12 attaccctgt tatccctaca tcatcaataa tataccttat tttggattga agccaatatg 60

ataatgaggg ggtggagttt gtgacgtggc gcggggcgtg ggaacggggc gggtgacgta 120 gtagtgtggc ggaagtgtga tgttgcaagt gtggcggaac acatgtaagc gacggatgtg 180

gcaaaagtga cgtttttggt gtgcgccggt gtacacagga agtgacaatt ttcgcgcggt 240 tttaggcgga tgttgtagta aatttgggcg taaccgagta agatttggcc attttcgcgg 300 gaaaactgaa taagaggaag tgaaatctga ataattttgt gttactcata gcgcgtaata 360

tttgtctagg gccgcgggga ctttgaccgt ttacgtggag actcgcccag gtgtttttct 420 caggtgtttt ccgcgttccg ggtcaaagtt ggcgttttat tattatagtc agctgacgtg 480 tagtgtattt atacccggtg agttcctcaa gaggccactc ttgagtgcca gcgagtagag 540

ttttctcctc cgagccgctc cgacaccggg actgaaaatg agacatatta tctgccacgg 600 aggtgttatt accgaagaaa tggccgccag tcttttggac cagctgatcg aagaggtact 660

ggctgataat cttccacctc ctagccattt tgaaccacct acccttcacg aactgtatga 720 tttagacgtg acggcccccg aagatcccaa cgaggaggcg gtttcgcaga tttttcccga 780 ctctgtaatg ttggcggtgc aggaagggat tgacttactc acttttccgc cggcgcccgg 840

ttctccggag ccgcctcacc tttcccggca gcccgagcag ccggagcaga gagccttggg 900 Page 201

Sequence_Listing.txt tccggtttct atgccaaacc ttgtaccgga ggtgatcgat cttacctgcc acgaggctgg 960

ctttccaccc agtgacgacg aggatgaaga gggtgaggag tttgtgttag attatgtgga 1020 gcaccccggg cacggttgca ggtcttgtca ttatcaccgg aggaatacgg gggacccaga 1080

tattatgtgt tcgctttgct atatgaggac ctgtggcatg tttgtctaca gtaagtgaaa 1140 attatgggca gtgggtgata gagtggtggg tttggtgtgg taattttttt tttaattttt 1200 acagttttgt ggtttaaaga attttgtatt gtgatttttt taaaaggtcc tgtgtctgaa 1260

cctgagcctg agcccgagcc agaaccggag cctgcaagac ctacccgccg tcctaaaatg 1320 gcgcctgcta tcctgagacg cccgacatca cctgtgtcta gagaatgcaa tagtagtacg 1380 gatagctgtg actccggtcc ttctaacaca cctcctgaga tacacccggt ggtcccgctg 1440

tgccccatta aaccagttgc cgtgagagtt ggtgggcgtc gccaggctgt ggaatgtatc 1500 gaggacttgc ttaacgagcc tgggcaacct ttggacttga gctgtaaacg ccccaggcca 1560 taaggtgtaa acctgtgatt gcgtgtgtgg ttaacgcctt tgtttgctga atgagttgat 1620

gtaagtttaa taaagggtga gataatgttt aacttgcatg gcgtgttaaa tggggcgggg 1680 cttaaagggt atataatgcg ccgtgggcta atcttggtta catctgacct catggaggct 1740

tgggagtgtt tggaagattt ttctgctgtg cgtaacttgc tggaacagag ctctaacagt 1800

acctcttggt tttggaggtt tctgtggggc tcatcccagg caaagttagt ctgcagaatt 1860

aaggaggatt acaagtggga atttgaagag cttttgaaat cctgtggtga gctgtttgat 1920

tctttgaatc tgggtcacca ggcgcttttc caagagaagg tcatcaagac tttggatttt 1980 tccacaccgg ggcgcgctgc ggctgctgtt gcttttttga gttttataaa ggataaatgg 2040

agcgaagaaa cccatctgag cggggggtac ctgctggatt ttctggccat gcatctgtgg 2100

agagcggttg tgagacacaa gaatcgcctg ctactgttgt cttccgtccg cccggcgata 2160 ataccgacgg aggagcagca gcagcagcag gaggaagcca ggcggcggcg gcaggagcag 2220

agcccatgga acccgagagc cggcctggac cctcgggaat gaatgttgta caggtggctg 2280 aactgtatcc agaactgaga cgcattttga caattacaga ggatgggcag gggctaaagg 2340 gggtaaagag ggagcggggg gcttgtgagg ctacagagga ggctaggaat ctagctttta 2400

gcttaatgac cagacaccgt cctgagtgta ttacttttca acagatcaag gataattgcg 2460 ctaatgagct tgatctgctg gcgcagaagt attccataga gcagctgacc acttactggc 2520 tgcagccagg ggatgatttt gaggaggcta ttagggtata tgcaaaggtg gcacttaggc 2580

cagattgcaa gtacaagatc agcaaacttg taaatatcag gaattgttgc tacatttctg 2640 ggaacggggc cgaggtggag atagatacgg aggatagggt ggcctttaga tgtagcatga 2700

taaatatgtg gccgggggtg cttggcatgg acggggtggt tattatgaat gtaaggttta 2760 ctggccccaa ttttagcggt acggttttcc tggccaatac caaccttatc ctacacggtg 2820 taagcttcta tgggtttaac aatacctgtg tggaagcctg gaccgatgta agggttcggg 2880

gctgtgcctt ttactgctgc tggaaggggg tggtgtgtcg ccccaaaagc agggcttcaa 2940 Page 202

Sequence_Listing.txt ttaagaaatg cctctttgaa aggtgtacct tgggtatcct gtctgagggt aactccaggg 3000

tgcgccacaa tgtggcctcc gactgtggtt gcttcatgct agtgaaaagc gtggctgtga 3060 ttaagcataa catggtatgt ggcaactgcg aggacagggc ctctcagatg ctgacctgct 3120

cggacggcaa ctgtcacctg ctgaagacca ttcacgtagc cagccactct cgcaaggcct 3180 ggccagtgtt tgagcataac atactgaccc gctgttcctt gcatttgggt aacaggaggg 3240 gggtgttcct accttaccaa tgcaatttga gtcacactaa gatattgctt gagcccgaga 3300

gcatgtccaa ggtgaacctg aacggggtgt ttgacatgac catgaagatc tggaaggtgc 3360 tgaggtacga tgagacccgc accaggtgca gaccctgcga gtgtggcggt aaacatatta 3420 ggaaccagcc tgtgatgctg gatgtgaccg aggagctgag gcccgatcac ttggtgctgg 3480

cctgcacccg cgctgagttt ggctctagcg atgaagatac agattgaggt actgaaatgt 3540 gtgggcgtgg cttaagggtg ggaaagaata tataaggtgg gggtcttatg tagttttgta 3600 tctgttttgc agcagccgcc gccgcccaac ttttctatac aaagttgtaa tgagcaccaa 3660

ctcgtttgat ggaagcattg tgagctcata tttgacaacg cgcatgcccc catgggccgg 3720 ggtgcgtcag aatgtgatgg gctccagcat tgatggtcgc cccgtcctgc ccgcaaactc 3780

tactaccttg acctacgaga ccgtgtctgg aacgccgttg gagactgcag cctccgccgc 3840

cgcttcagcc gctgcagcca ccgcccgcgg gattgtgact gactttgctt tcctgagccc 3900

gcttgcaagc agtgcagctt cccgttcatc cgcccgcgat gacaagttga cggctctttt 3960

ggcacaattg gattctttga cccgggaact taatgtcgtt tctcagcagc tgttggatct 4020 gcgccagcag gtttctgccc tgaaggcttc ctcccctccc aatgcggttt aaaacataaa 4080

taaaaaacca gactctgttt ggatttggat caagcataag tgtcttgctg tctttattta 4140

ggggttttgc gcgcgcggta ggcccgggac cagcggtctc ggtcgttgag ggtcctgtgt 4200 attttttcca ggacgtggta aaggtgactc tggatgttca gatacatggg cataagcccg 4260

tctctggggt ggaggtagca ccactgcaga gcttcatgct gcggggtggt gttgtagatg 4320 atccagtcgt agcaggagcg ctgggcgtgg tgcctaaaaa tgtctttcag tagcaagctg 4380 attgccaggg gcaggccctt ggtgtaagtg tttacaaagc ggttaagctg ggatgggtgc 4440

atacgtgggg atatgagatg catcttggac tgtattttta ggttggctat gttcccagcc 4500 atatccctcc ggggattcat gttgtgcaga accaccagca cagtgtatcc ggtgcacttg 4560 ggaaatttgt catgtagctt agaaggaaat gcgtggaaga acttggagac gcccttgtga 4620

cctccaagat tttccatgca ttcgtccata atgatggcaa tgggcccacg ggcggcggcc 4680 tgggcgaaga tatttctggg atcactaacg tcatagttgt gttccaggat gagatcgtca 4740

taggccattt ttacaaagcg cgggcggagg gtgccagact gcggtataat ggttccatcc 4800 ggcccagggg cgtagttacc ctcacagatt tgcatttccc acgctttgag ttcagatggg 4860 gggatcatgt ctacctgcgg ggcgatgaag aaaacggttt ccggggtagg ggagatcagc 4920

tgggaagaaa gcaggttcct gagcagctgc gacttaccgc agccggtggg cccgtaaatc 4980 Page 203

Sequence_Listing.txt acacctatta ccgggtgcaa ctggtagtta agagagctgc agctgccgtc atccctgagc 5040

aggggggcca cttcgttaag catgtccctg actcgcatgt tttccctgac caaatccgcc 5100 agaaggcgct cgccgcccag cgatagcagt tcttgcaagg aagcaaagtt tttcaacggt 5160

ttgagaccgt ccgccgtagg catgcttttg agcgtttgac caagcagttc caggcggtcc 5220 cacagctcgg tcacctgctc tacggcatct cgatccagca tatctcctcg tttcgcgggt 5280 tggggcggct ttcgctgtac ggcagtagtc ggtgctcgtc cagacgggcc agggtcatgt 5340

ctttccacgg gcgcagggtc ctcgtcagcg tagtctgggt cacggtgaag gggtgcgctc 5400 cgggctgcgc gctggccagg gtgcgcttga ggctggtcct gctggtgctg aagcgctgcc 5460 ggtcttcgcc ctgcgcgtcg gccaggtagc atttgaccat ggtgtcatag tccagcccct 5520

ccgcggcgtg gcccttggcg cgcagcttgc ccttggagga ggcgccgcac gaggggcagt 5580 gcagactttt gagggcgtag agcttgggcg cgagaaatac cgattccggg gagtaggcat 5640 ccgcgccgca ggccccgcag acggtctcgc attccacgag ccaggtgagc tctggccgtt 5700

cggggtcaaa aaccaggttt cccccatgct ttttgatgcg tttcttacct ctggtttcca 5760 tgagccggtg tccacgctcg gtgacgaaaa ggctgtccgt gtccccgtat acagacttga 5820

gaggcctgtc ctcgagcggt gttccgcggt cctcctcgta tagaaactcg gaccactctg 5880

agacaaaggc tcgcgtccag gccagcacga aggaggctaa gtgggagggg tagcggtcgt 5940

tgtccactag ggggtccact cgctccaggg tgtgaagaca catgtcgccc tcttcggcat 6000

caaggaaggt gattggtttg taggtgtagg ccacgtgacc gggtgttcct gaaggggggc 6060 tataaaaggg ggtgggggcg cgttcgtcct cactctcttc cgcatcgctg tctgcgaggg 6120

ccagctgttg gggtgagtac tccctctgaa aagcgggcat gacttctgcg ctaagattgt 6180

cagtttccaa aaacgaggag gatttgatat tcacctggcc cgcggtgatg cctttgaggg 6240 tggccgcatc catctggtca gaaaagacaa tctttttgtt gtcaagcttg gtggcaaacg 6300

acccgtagag ggcgttggac agcaacttgg cgatggagcg cagggtttgg tttttgtcgc 6360 gatcggcgcg ctccttggcc gcgatgttta gctgcacgta ttcgcgcgca acgcaccgcc 6420 attcgggaaa gacggtggtg cgctcgtcgg gcaccaggtg cacgcgccaa ccgcggttgt 6480

gcagggtgac aaggtcaacg ctggtggcta cctctccgcg taggcgctcg ttggtccagc 6540 agaggcggcc gcccttgcgc gagcagaatg gcggtagggg gtctagctgc gtctcgtccg 6600 gggggtctgc gtccacggta aagaccccgg gcagcaggcg cgcgtcgaag tagtctatct 6660

tgcatccttg caagtctagc gcctgctgcc atgcgcgggc ggcaagcgcg cgctcgtatg 6720 ggttgagtgg gggaccccat ggcatggggt gggtgagcgc ggaggcgtac atgccgcaaa 6780

tgtcgtaaac gtagaggggc tctctgagta ttccaagata tgtagggtag catcttccac 6840 cgcggatgct ggcgcgcacg taatcgtata gttcgtgcga gggagcgagg aggtcgggac 6900 cgaggttgct acgggcgggc tgctctgctc ggaagactat ctgcctgaag atggcatgtg 6960

agttggatga tatggttgga cgctggaaga cgttgaagct ggcgtctgtg agacctaccg 7020 Page 204

Sequence_Listing.txt cgtcacgcac gaaggaggcg taggagtcgc gcagcttgtt gaccagctcg gcggtgacct 7080

gcacgtctag ggcgcagtag tccagggttt ccttgatgat gtcatactta tcctgtccct 7140 tttttttcca cagctcgcgg ttgaggacaa actcttcgcg gtctttccag tactcttgga 7200

tcggaaaccc gtcggcctcc gaacggtaag agcctagcat gtagaactgg ttgacggcct 7260 ggtaggcgca gcatcccttt tctacgggta gcgcgtatgc ctgcgcggcc ttccggagcg 7320 aggtgtgggt gagcgcaaag gtgtccctga ccatgacttt gaggtactgg tatttgaagt 7380

cagtgtcgtc gcatccgccc tgctcccaga gcaaaaagtc cgtgcgcttt ttggaacgcg 7440 gatttggcag ggcgaaggtg acatcgttga agagtatctt tcccgcgcga ggcataaagt 7500 tgcgtgtgat gcggaagggt cccggcacct cggaacggtt gttaattacc tgggcggcga 7560

gcacgatctc gtcaaagccg ttgatgttgt ggcccacaat gtaaagttcc aagaagcgcg 7620 ggatgccctt gatggaaggc aattttttaa gttcctcgta ggtgagctct tcaggggagc 7680 tgagcccgtg ctctgaaagg gcccagtctg caagatgagg gttggaagcg acgaatgagc 7740

tccacaggtc acgggccatt agcatttgca ggtggtcgcg aaaggtccta aactggcgac 7800 ctatggccat tttttctggg gtgatgcagt agaaggtaag cgggtcttgt tcccagcggt 7860

cccatccaag gttcgcggct aggtctcgcg cggcagtcac tagaggctca tctccgccga 7920

acttcatgac cagcatgaag ggcacgagct gcttcccaaa ggcccccatc caagtatagg 7980

tctctacatc gtaggtgaca aagagacgct cggtgcgagg atgcgagccg atcgggaaga 8040

actggatctc ccgccaccaa ttggaggagt ggctattgat gtggtgaaag tagaagtccc 8100 tgcgacgggc cgaacactcg tgctggcttt tgtaaaaacg tgcgcagtac tggcagcggt 8160

gcacgggctg tacatcctgc acgaggttga cctgacgacc gcgcacaagg aagcagagtg 8220

ggaatttgag cccctcgcct ggcgggtttg gctggtggtc ttctacttcg gctgcttgtc 8280 cttgaccgtc tggctgctcg aggggagtta cggtggatcg gaccaccacg ccgcgcgagc 8340

ccaaagtcca gatgtccgcg cgcggcggtc ggagcttgat gacaacatcg cgcagatggg 8400 agctgtccat ggtctggagc tcccgcggcg tcaggtcagg cgggagctcc tgcaggttta 8460 cctcgcatag acgggtcagg gcgcgggcta gatccaggtg atacctaatt tccaggggct 8520

ggttggtggc ggcgtcgatg gcttgcaaga ggccgcatcc ccgcggcgcg actacggtac 8580 cgcgcggcgg gcggtgggcc gcgggggtgt ccttggatga tgcatctaaa agcggtgacg 8640 cgggcgagcc cccggaggta gggggggctc cggacccgcc gggagagggg gcaggggcac 8700

gtcggcgccg cgcgcgggca ggagctggtg ctgcgcgcgt aggttgctgg cgaacgcgac 8760 gacgcggcgg ttgatctcct gaatctggcg cctctgcgtg aagacgacgg gcccggtgag 8820

cttgagcctg aaagagagtt cgacagaatc aatttcggtg tcgttgacgg cggcctggcg 8880 caaaatctcc tgcacgtctc ctgagttgtc ttgataggcg atctcggcca tgaactgctc 8940 gatctcttcc tcctggagat ctccgcgtcc ggctcgctcc acggtggcgg cgaggtcgtt 9000

ggaaatgcgg gccatgagct gcgagaaggc gttgaggcct ccctcgttcc agacgcggct 9060 Page 205

Sequence_Listing.txt gtagaccacg cccccttcgg catcgcgggc gcgcatgacc acctgcgcga gattgagctc 9120

cacgtgccgg gcgaagacgg cgtagtttcg caggcgctga aagaggtagt tgagggtggt 9180 ggcggtgtgt tctgccacga agaagtacat aacccagcgt cgcaacgtgg attcgttgat 9240

atcccccaag gcctcaaggc gctccatggc ctcgtagaag tccacggcga agttgaaaaa 9300 ctgggagttg cgcgccgaca cggttaactc ctcctccaga agacggatga gctcggcgac 9360 agtgtcgcgc acctcgcgct caaaggctac aggggcctct tcttcttctt caatctcctc 9420

ttccataagg gcctcccctt cttcttcttc tggcggcggt gggggagggg ggacacggcg 9480 gcgacgacgg cgcaccggga ggcggtcgac aaagcgctcg atcatctccc cgcggcgacg 9540 gcgcatggtc tcggtgacgg cgcggccgtt ctcgcggggg cgcagttgga agacgccgcc 9600

cgtcatgtcc cggttatggg ttggcggggg gctgccatgc ggcagggata cggcgctaac 9660 gatgcatctc aacaattgtt gtgtaggtac tccgccgccg agggacctga gcgagtccgc 9720 atcgaccgga tcggaaaacc tctcgagaaa ggcgtctaac cagtcacagt cgcaaggtag 9780

gctgagcacc gtggcgggcg gcagcgggcg gcggtcgggg ttgtttctgg cggaggtgct 9840 gctgatgatg taattaaagt aggcggtctt gagacggcgg atggtcgaca gaagcaccat 9900

gtccttgggt ccggcctgct gaatgcgcag gcggtcggcc atgccccagg cttcgttttg 9960

acatcggcgc aggtctttgt agtagtcttg catgagcctt tctaccggca cttcttcttc 10020

tccttcctct tgtcctgcat ctcttgcatc tatcgctgcg gcggcggcgg agtttggccg 10080

taggtggcgc cctcttcctc ccatgcgtgt gaccccgaag cccctcatcg gctgaagcag 10140 ggctaggtcg gcgacaacgc gctcggctaa tatggcctgc tgcacctgcg tgagggtaga 10200

ctggaagtca tccatgtcca caaagcggtg gtatgcgccc gtgttgatgg tgtaagtgca 10260

gttggccata acggaccagt taacggtctg gtgacccggc tgcgagagct cggtgtacct 10320 gagacgcgag taagccctcg agtcaaatac gtagtcgttg caagtccgca ccaggtactg 10380

gtatcccacc aaaaagtgcg gcggcggctg gcggtagagg ggccagcgta gggtggccgg 10440 ggctccgggg gcgagatctt ccaacataag gcgatgatat ccgtagatgt acctggacat 10500 ccaggtgatg ccggcggcgg tggtggaggc gcgcggaaag tcgcggacgc ggttccagat 10560

gttgcgcagc ggcaaaaagt gctccatggt cgggacgctc tggccggtca ggcgcgcgca 10620 atcgttgacg ctctagaccg tgcaaaagga gagcctgtaa gcgggcactc ttccgtggtc 10680 tggtggataa attcgcaagg gtatcatggc ggacgaccgg ggttcgagcc ccgtatccgg 10740

ccgtccgccg tgatccatgc ggttaccgcc cgcgtgtcga acccaggtgt gcgacgtcag 10800 acaacggggg agtgctcctt ttggcttcct tccaggcgcg gcggctgctg cgctagcttt 10860

tttggccact ggccgcgcgc agcgtaagcg gttaggctgg aaagcgaaag cattaagtgg 10920 ctcgctccct gtagccggag ggttattttc caagggttga gtcgcgggac ccccggttcg 10980 agtctcggac cggccggact gcggcgaacg ggggtttgcc tccccgtcat gcaagacccc 11040

gcttgcaaat tcctccggaa acagggacga gccccttttt tgcttttccc agatgcatcc 11100 Page 206

Sequence_Listing.txt ggtgctgcgg cagatgcgcc cccctcctca gcagcggcaa gagcaagagc agcggcagac 11160

atgcagggca ccctcccctc ctcctaccgc gtcaggaggg gcgacatccg cggttgacgc 11220 ggcagcagat ggtgattacg aacccccgcg gcgccgggcc cggcactacc tggacttgga 11280

ggagggcgag ggcctggcgc ggctaggagc gccctctcct gagcggtacc caagggtgca 11340 gctgaagcgt gatacgcgtg aggcgtacgt gccgcggcag aacctgtttc gcgaccgcga 11400 gggagaggag cccgaggaga tgcgggatcg aaagttccac gcagggcgcg agctgcggca 11460

tggcctgaat cgcgagcggt tgctgcgcga ggaggacttt gagcccgacg cgcgaaccgg 11520 gattagtccc gcgcgcgcac acgtggcggc cgccgacctg gtaaccgcat acgagcagac 11580 ggtgaaccag gagattaact ttcaaaaaag ctttaacaac cacgtgcgta cgcttgtggc 11640

gcgcgaggag gtggctatag gactgatgca tctgtgggac tttgtaagcg cgctggagca 11700 aaacccaaat agcaagccgc tcatggcgca gctgttcctt atagtgcagc acagcaggga 11760 caacgaggca ttcagggatg cgctgctaaa catagtagag cccgagggcc gctggctgct 11820

cgatttgata aacatcctgc agagcatagt ggtgcaggag cgcagcttga gcctggctga 11880 caaggtggcc gccatcaact attccatgct tagcctgggc aagttttacg cccgcaagat 11940

ataccatacc ccttacgttc ccatagacaa ggaggtaaag atcgaggggt tctacatgcg 12000

catggcgctg aaggtgctta ccttgagcga cgacctgggc gtttatcgca acgagcgcat 12060

ccacaaggcc gtgagcgtga gccggcggcg cgagctcagc gaccgcgagc tgatgcacag 12120

cctgcaaagg gccctggctg gcacgggcag cggcgataga gaggccgagt cctactttga 12180 cgcgggcgct gacctgcgct gggccccaag ccgacgcgcc ctggaggcag ctggggccgg 12240

acctgggctg gcggtggcac ccgcgcgcgc tggcaacgtc ggcggcgtgg aggaatatga 12300

cgaggacgat gagtacgagc cagaggacgg cgagtactaa gcggtgatgt ttctgatcag 12360 atgatgcaag acgcaacgga cccggcggtg cgggcggcgc tgcagagcca gccgtccggc 12420

cttaactcca cggacgactg gcgccaggtc atggaccgca tcatgtcgct gactgcgcgc 12480 aatcctgacg cgttccggca gcagccgcag gccaaccggc tctccgcaat tctggaagcg 12540 gtggtcccgg cgcgcgcaaa ccccacgcac gagaaggtgc tggcgatcgt aaacgcgctg 12600

gccgaaaaca gggccatccg gcccgacgag gccggcctgg tctacgacgc gctgcttcag 12660 cgcgtggctc gttacaacag cggcaacgtg cagaccaacc tggaccggct ggtgggggat 12720 gtgcgcgagg ccgtggcgca gcgtgagcgc gcgcagcagc agggcaacct gggctccatg 12780

gttgcactaa acgccttcct gagtacacag cccgccaacg tgccgcgggg acaggaggac 12840 tacaccaact ttgtgagcgc actgcggcta atggtgactg agacaccgca aagtgaggtg 12900

taccagtctg ggccagacta ttttttccag accagtagac aaggcctgca gaccgtaaac 12960 ctgagccagg ctttcaaaaa cttgcagggg ctgtgggggg tgcgggctcc cacaggcgac 13020 cgcgcgaccg tgtctagctt gctgacgccc aactcgcgcc tgttgctgct gctaatagcg 13080

cccttcacgg acagtggcag cgtgtcccgg gacacatacc taggtcactt gctgacactg 13140 Page 207

Sequence_Listing.txt taccgcgagg ccataggtca ggcgcatgtg gacgagcata ctttccagga gattacaagt 13200

gtcagccgcg cgctggggca ggaggacacg ggcagcctgg aggcaaccct aaactacctg 13260 ctgaccaacc ggcggcagaa gatcccctcg ttgcacagtt taaacagcga ggaggagcgc 13320

attttgcgct acgtgcagca gagcgtgagc cttaacctga tgcgcgacgg ggtaacgccc 13380 agcgtggcgc tggacatgac cgcgcgcaac atggaaccgg gcatgtatgc ctcaaaccgg 13440 ccgtttatca accgcctaat ggactacttg catcgcgcgg ccgccgtgaa ccccgagtat 13500

ttcaccaatg ccatcttgaa cccgcactgg ctaccgcccc ctggtttcta caccggggga 13560 ttcgaggtgc ccgagggtaa cgatggattc ctctgggacg acatagacga cagcgtgttt 13620 tccccgcaac cgcagaccct gctagagttg caacagcgcg agcaggcaga ggcggcgctg 13680

cgaaaggaaa gcttccgcag gccaagcagc ttgtccgatc taggcgctgc ggccccgcgg 13740 tcagatgcta gtagcccatt tccaagcttg atagggtctc ttaccagcac tcgcaccacc 13800 cgcccgcgcc tgctgggcga ggaggagtac ctaaacaact cgctgctgca gccgcagcgc 13860

gaaaaaaacc tgcctccggc atttcccaac aacgggatag agagcctagt ggacaagatg 13920 agtagatgga agacgtacgc gcaggagcac agggacgtgc caggcccgcg cccgcccacc 13980

cgtcgtcaaa ggcacgaccg tcagcggggt ctggtgtggg aggacgatga ctcggcagac 14040

gacagcagcg tcctggattt gggagggagt ggcaacccgt ttgcgcacct tcgccccagg 14100

ctggggagaa tgttttaaaa aaaaaaaagc atgatgcaaa ataaaaaact caccaaggcc 14160

atggcaccga gcgttggttt tcttgtattc cccttagtat gcggcgcgcg gcgatgtatg 14220 aggaaggtcc tcctccctcc tacgagagtg tggtgagcgc ggcgccagtg gcggcggcgc 14280

tgggttctcc cttcgatgct cccctggacc cgccgtttgt gcctccgcgg tacctgcggc 14340

ctaccggggg gagaaacagc atccgttact ctgagttggc acccctattc gacaccaccc 14400 gtgtgtacct ggtggacaac aagtcaacgg atgtggcatc cctgaactac cagaacgacc 14460

acagcaactt tctgaccacg gtcattcaaa acaatgacta cagcccgggg gaggcaagca 14520 cacagaccat caatcttgac gaccggtcgc actggggcgg cgacctgaaa accatcctgc 14580 ataccaacat gccaaatgtg aacgagttca tgtttaccaa taagtttaag gcgcgggtga 14640

tggtgtcgcg cttgcctact aaggacaatc aggtggagct gaaatacgag tgggtggagt 14700 tcacgctgcc cgagggcaac tactccgaga ccatgaccat agaccttatg aacaacgcga 14760 tcgtggagca ctacttgaaa gtgggcagac agaacggggt tctggaaagc gacatcgggg 14820

taaagtttga cacccgcaac ttcagactgg ggtttgaccc cgtcactggt cttgtcatgc 14880 ctggggtata tacaaacgaa gccttccatc cagacatcat tttgctgcca ggatgcgggg 14940

tggacttcac ccacagccgc ctgagcaact tgttgggcat ccgcaagcgg caacccttcc 15000 aggagggctt taggatcacc tacgatgatc tggagggtgg taacattccc gcactgttgg 15060 atgtggacgc ctaccaggcg agcttgaaag atgacaccga acagggcggg ggtggcgcag 15120

gcggcagcaa cagcagtggc agcggcgcgg aagagaactc caacgcggca gccgcggcaa 15180 Page 208

Sequence_Listing.txt tgcagccggt ggaggacatg aacgatcatg ccattcgcgg cgacaccttt gccacacggg 15240

ctgaggagaa gcgcgctgag gccgaagcag cggccgaagc tgccgccccc gctgcgcaac 15300 ccgaggtcga gaagcctcag aagaaaccgg tgatcaaacc cctgacagag gacagcaaga 15360

aacgcagtta caacctaata agcaatgaca gcaccttcac ccagtaccgc agctggtacc 15420 ttgcatacaa ctacggcgac cctcagaccg gaatccgctc atggaccctg ctttgcactc 15480 ctgacgtaac ctgcggctcg gagcaggtct actggtcgtt gccagacatg atgcaagacc 15540

ccgtgacctt ccgctccacg cgccagatca gcaactttcc ggtggtgggc gccgagctgt 15600 tgcccgtgca ctccaagagc ttctacaacg accaggccgt ctactcccaa ctcatccgcc 15660 agtttacctc tctgacccac gtgttcaatc gctttcccga gaaccagatt ttggcgcgcc 15720

cgccagcccc caccatcacc accgtcagtg aaaacgttcc tgctctcaca gatcacggga 15780 cgctaccgct gcgcaacagc atcggaggag tccagcgagt gaccattact gacgccagac 15840 gccgcacctg cccctacgtt tacaaggccc tgggcatagt ctcgccgcgc gtcctatcga 15900

gccgcacttt ttgagcaagc atgtccatcc ttatatcgcc cagcaataac acaggctggg 15960 gcctgcgctt cccaagcaag atgtttggcg gggccaagaa gcgctccgac caacacccag 16020

tgcgcgtgcg cgggcactac cgcgcgccct ggggcgcgca caaacgcggc cgcactgggc 16080

gcaccaccgt cgatgacgcc atcgacgcgg tggtggagga ggcgcgcaac tacacgccca 16140

cgccgccacc agtgtccaca gtggacgcgg ccattcagac cgtggtgcgc ggagcccggc 16200

gctatgctaa aatgaagaga cggcggaggc gcgtagcacg tcgccaccgc cgccgacccg 16260 gcactgccgc ccaacgcgcg gcggcggccc tgcttaaccg cgcacgtcgc accggccgac 16320

gggcggccat gcgggccgct cgaaggctgg ccgcgggtat tgtcactgtg ccccccaggt 16380

ccaggcgacg agcggccgcc gcagcagccg cggccattag tgctatgact cagggtcgca 16440 ggggcaacgt gtattgggtg cgcgactcgg ttagcggcct gcgcgtgccc gtgcgcaccc 16500

gccccccgcg caactagatt gcaagaaaaa actacttaga ctcgtactgt tgtatgtatc 16560 cagcggcggc ggcgcgcaac gaagctatgt ccaagcgcaa aatcaaagaa gagatgctcc 16620 aggtcatcgc gccggagatc tatggccccc cgaagaagga agagcaggat tacaagcccc 16680

gaaagctaaa gcgggtcaaa aagaaaaaga aagatgatga tgatgaactt gacgacgagg 16740 tggaactgct gcacgctacc gcgcccaggc gacgggtaca gtggaaaggt cgacgcgtaa 16800 aacgtgtttt gcgacccggc accaccgtag tctttacgcc cggtgagcgc tccacccgca 16860

cctacaagcg cgtgtatgat gaggtgtacg gcgacgagga cctgcttgag caggccaacg 16920 agcgcctcgg ggagtttgcc tacggaaagc ggcataagga catgctggcg ttgccgctgg 16980

acgagggcaa cccaacacct agcctaaagc ccgtaacact gcagcaggtg ctgcccgcgc 17040 ttgcaccgtc cgaagaaaag cgcggcctaa agcgcgagtc tggtgacttg gcacccaccg 17100 tgcagctgat ggtacccaag cgccagcgac tggaagatgt cttggaaaaa atgaccgtgg 17160

aacctgggct ggagcccgag gtccgcgtgc ggccaatcaa gcaggtggcg ccgggactgg 17220 Page 209

Sequence_Listing.txt gcgtgcagac cgtggacgtt cagataccca ctaccagtag caccagtatt gccaccgcca 17280

cagagggcat ggagacacaa acgtccccgg ttgcctcagc ggtggcggat gccgcggtgc 17340 aggcggtcgc tgcggccgcg tccaagacct ctacggaggt gcaaacggac ccgtggatgt 17400

ttcgcgtttc agccccccgg cgcccgcgcg gttcgaggaa gtacggcgcc gccagcgcgc 17460 tactgcccga atatgcccta catccttcca ttgcgcctac ccccggctat cgtggctaca 17520 cctaccgccc cagaagacga gcaactaccc gacgccgaac caccactgga acccgccgcc 17580

gccgtcgccg tcgccagccc gtgctggccc cgatttccgt gcgcagggtg gctcgcgaag 17640 gaggcaggac cctggtgctg ccaacagcgc gctaccaccc cagcatcgtt taaaagccgg 17700 tctttgtggt tcttgcagat atggccctca cctgccgcct ccgtttcccg gtgccgggat 17760

tccgaggaag aatgcaccgt aggaggggca tggccggcca cggcctgacg ggcggcatgc 17820 gtcgtgcgca ccaccggcgg cggcgcgcgt cgcaccgtcg catgcgcggc ggtatcctgc 17880 ccctccttat tccactgatc gccgcggcga ttggcgccgt gcccggaatt gcatccgtgg 17940

ccttgcaggc gcagagacac tgattaaaaa caagttgcat gtggaaaaat caaaataaaa 18000 agtctggact ctcacgctcg cttggtcctg taactatttt gtagaatgga agacatcaac 18060

tttgcgtctc tggccccgcg acacggctcg cgcccgttca tgggaaactg gcaagatatc 18120

ggcaccagca atatgagcgg tggcgccttc agctggggct cgctgtggag cggcattaaa 18180

aatttcggtt ccaccgttaa gaactatggc agcaaggcct ggaacagcag cacaggccag 18240

atgctgaggg ataagttgaa agagcaaaat ttccaacaaa aggtggtaga tggcctggcc 18300 tctggcatta gcggggtggt ggacctggcc aaccaggcag tgcaaaataa gattaacagt 18360

aagcttgatc cccgccctcc cgtagaggag cctccaccgg ccgtggagac agtgtctcca 18420

gaggggcgtg gcgaaaagcg tccgcgcccc gacagggaag aaactctggt gacgcaaata 18480 gacgagcctc cctcgtacga ggaggcacta aagcaaggcc tgcccaccac ccgtcccatc 18540

gcgcccatgg ctaccggagt gctgggccag cacacacccg taacgctgga cctgcctccc 18600 cccgccgaca cccagcagaa acctgtgctg ccaggcccga ccgccgttgt tgtaacccgt 18660 cctagccgcg cgtccctgcg ccgcgccgcc agcggtccgc gatcgttgcg gcccgtagcc 18720

agtggcaact ggcaaagcac actgaacagc atcgtgggtc tgggggtgca atccctgaag 18780 cgccgacgat gcttctgaat agctaacgtg tcgtatgtgt gtcatgtatg cgtccatgtc 18840 gccgccagag gagctgctga gccgccgcgc gcccgctttc caagatggct accccttcga 18900

tgatgccgca gtggtcttac atgcacatct cgggccagga cgcctcggag tacctgagcc 18960 ccgggctggt gcagtttgcc cgcgccaccg agacgtactt cagcctgaat aacaagttta 19020

gaaaccccac ggtggcgcct acgcacgacg tgaccacaga ccggtcccag cgtttgacgc 19080 tgcggttcat ccctgtggac cgtgaggata ctgcgtactc gtacaaggcg cggttcaccc 19140 tagctgtggg tgataaccgt gtgctggaca tggcttccac gtactttgac atccgcggcg 19200

tgctggacag gggccctact tttaagccct actctggcac tgcctacaac gccctggctc 19260 Page 210

Sequence_Listing.txt ccaagggtgc cccaaatcct tgcgaatggg atgaagctgc tactgctctt gaaataaacc 19320

tagaagaaga ggacgatgac aacgaagacg aagtagacga gcaagctgag cagcaaaaaa 19380 ctcacgtatt tgggcaggcg ccttattctg gtataaatat tacaaaggag ggtattcaaa 19440

taggtgtcga aggtcaaaca cctaaatatg ccgataaaac atttcaacct gaacctcaaa 19500 taggagaatc tcagtggtac gaaactgaaa ttaatcatgc agctgggaga gtccttaaaa 19560 agactacccc aatgaaacca tgttacggtt catatgcaaa acccacaaat gaaaatggag 19620

ggcaaggcat tcttgtaaag caacaaaatg gaaagctaga aagtcaagtg gaaatgcaat 19680 ttttctcaac tactgaggcg accgcaggca atggtgataa cttgactcct aaagtggtat 19740 tgtacagtga agatgtagat atagaaaccc cagacactca tatttcttac atgcccacta 19800

ttaaggaagg taactcacga gaactaatgg gccaacaatc tatgcccaac aggcctaatt 19860 acattgcttt tagggacaat tttattggtc taatgtatta caacagcacg ggtaatatgg 19920 gtgttctggc gggccaagca tcgcagttga atgctgttgt agatttgcaa gacagaaaca 19980

cagagctttc ataccagctt ttgcttgatt ccattggtga tagaaccagg tacttttcta 20040 tgtggaatca ggctgttgac agctatgatc cagatgttag aattattgaa aatcatggaa 20100

ctgaagatga acttccaaat tactgctttc cactgggagg tgtgattaat acagagactc 20160

ttaccaaggt aaaacctaaa acaggtcagg aaaatggatg ggaaaaagat gctacagaat 20220

tttcagataa aaatgaaata agagttggaa ataattttgc catggaaatc aatctaaatg 20280

ccaacctgtg gagaaatttc ctgtactcca acatagcgct gtatttgccc gacaagctaa 20340 agtacagtcc ttccaacgta aaaatttctg ataacccaaa cacctacgac tacatgaaca 20400

agcgagtggt ggctcccggg ttagtggact gctacattaa ccttggagca cgctggtccc 20460

ttgactatat ggacaacgtc aacccattta accaccaccg caatgctggc ctgcgctacc 20520 gctcaatgtt gctgggcaat ggtcgctatg tgcccttcca catccaggtg cctcagaagt 20580

tctttgccat taaaaacctc cttctcctgc cgggctcata cacctacgag tggaacttca 20640 ggaaggatgt taacatggtt ctgcagagct ccctaggaaa tgacctaagg gttgacggag 20700 ccagcattaa gtttgatagc atttgccttt acgccacctt cttccccatg gcccacaaca 20760

ccgcctccac gcttgaggcc atgcttagaa acgacaccaa cgaccagtcc tttaacgact 20820 atctctccgc cgccaacatg ctctacccta tacccgccaa cgctaccaac gtgcccatat 20880 ccatcccctc ccgcaactgg gcggctttcc gcggctgggc cttcacgcgc cttaagacta 20940

aggaaacccc atcactgggc tcgggctacg acccttatta cacctactct ggctctatac 21000 cctacctaga tggaaccttt tacctcaacc acacctttaa gaaggtggcc attacctttg 21060

actcttctgt cagctggcct ggcaatgacc gcctgcttac ccccaacgag tttgaaatta 21120 agcgctcagt tgacggggag ggttacaacg ttgcccagtg taacatgacc aaagactggt 21180 tcctggtaca aatgctagct aactacaaca ttggctacca gggcttctat atcccagaga 21240

gctacaagga ccgcatgtac tccttcttta gaaacttcca gcccatgagc cgtcaggtgg 21300 Page 211

Sequence_Listing.txt tggatgatac taaatacaag gactaccaac aggtgggcat cctacaccaa cacaacaact 21360

ctggatttgt tggctacctt gcccccacca tgcgcgaagg acaggcctac cctgctaact 21420 tcccctatcc gcttataggc aagaccgcag ttgacagcat tacccagaaa aagtttcttt 21480

gcgatcgcac cctttggcgc atcccattct ccagtaactt tatgtccatg ggcgcactca 21540 cagacctggg ccaaaacctt ctctacgcca actccgccca cgcgctagac atgacttttg 21600 aggtggatcc catggacgag cccacccttc tttatgtttt gtttgaagtc tttgacgtgg 21660

tccgtgtgca ccggccgcac cgcggcgtca tcgaaaccgt gtacctgcgc acgcccttct 21720 cggccggcaa cgccacaaca taaagaagca agcaacatca acaacagctg ccgccatggg 21780 ctccagtgag caggaactga aagccattgt caaagatctt ggttgtgggc catatttttt 21840

gggcacctat gacaagcgct ttccaggctt tgtttctcca cacaagctcg cctgcgccat 21900 agtcaatacg gccggtcgcg agactggggg cgtacactgg atggcctttg cctggaaccc 21960 gcactcaaaa acatgctacc tctttgagcc ctttggcttt tctgaccagc gactcaagca 22020

ggtttaccag tttgagtacg agtcactcct gcgccgtagc gccattgctt cttcccccga 22080 ccgctgtata acgctggaaa agtccaccca aagcgtacag gggcccaact cggccgcctg 22140

tggactattc tgctgcatgt ttctccacgc ctttgccaac tggccccaaa ctcccatgga 22200

tcacaacccc accatgaacc ttattaccgg ggtacccaac tccatgctca acagtcccca 22260

ggtacagccc accctgcgtc gcaaccagga acagctctac agcttcctgg agcgccactc 22320

gccctacttc cgcagccaca gtgcgcagat taggagcgcc acttcttttt gtcacttgaa 22380 aaacatgtaa aaataatgta ctagagacac tttcaataaa ggcaaatgct tttatttgta 22440

cactctcggg tgattattta cccccaccct tgccgtctgc gccgtttaaa aatcaaaggg 22500

gttctgccgc gcatcgctat gcgccactgg cagggacacg ttgcgatact ggtgtttagt 22560 gctccactta aactcaggca caaccatccg cggcagctcg gtgaagtttt cactccacag 22620

gctgcgcacc atcaccaacg cgtttagcag gtcgggcgcc gatatcttga agtcgcagtt 22680 ggggcctccg ccctgcgcgc gcgagttgcg atacacaggg ttgcagcact ggaacactat 22740 cagcgccggg tggtgcacgc tggccagcac gctcttgtcg gagatcagat ccgcgtccag 22800

gtcctccgcg ttgctcaggg cgaacggagt caactttggt agctgccttc ccaaaaaggg 22860 cgcgtgccca ggctttgagt tgcactcgca ccgtagtggc atcaaaaggt gaccgtgccc 22920 ggtctgggcg ttaggataca gcgcctgcat aaaagccttg atctgcttaa aagccacctg 22980

agcctttgcg ccttcagaga agaacatgcc gcaagacttg ccggaaaact gattggccgg 23040 acaggccgcg tcgtgcacgc agcaccttgc gtcggtgttg gagatctgca ccacatttcg 23100

gccccaccgg ttcttcacga tcttggcctt gctagactgc tccttcagcg cgcgctgccc 23160 gttttcgctc gtcacatcca tttcaatcac gtgctcctta tttatcataa tgcttccgtg 23220 tagacactta agctcgcctt cgatctcagc gcagcggtgc agccacaacg cgcagcccgt 23280

gggctcgtga tgcttgtagg tcacctctgc aaacgactgc aggtacgcct gcaggaatcg 23340 Page 212

Sequence_Listing.txt ccccatcatc gtcacaaagg tcttgttgct ggtgaaggtc agctgcaacc cgcggtgctc 23400

ctcgttcagc caggtcttgc atacggccgc cagagcttcc acttggtcag gcagtagttt 23460 gaagttcgcc tttagatcgt tatccacgtg gtacttgtcc atcagcgcgc gcgcagcctc 23520

catgcccttc tcccacgcag acacgatcgg cacactcagc gggttcatca ccgtaatttc 23580 actttccgct tcgctgggct cttcctcttc ctcttgcgtc cgcataccac gcgccactgg 23640 gtcgtcttca ttcagccgcc gcactgtgcg cttacctcct ttgccatgct tgattagcac 23700

cggtgggttg ctgaaaccca ccatttgtag cgccacatct tctctttctt cctcgctgtc 23760 cacgattacc tctggtgatg gcgggcgctc gggcttggga gaagggcgct tctttttctt 23820 cttgggcgca atggccaaat ccgccgccga ggtcgatggc cgcgggctgg gtgtgcgcgg 23880

caccagcgcg tcttgtgatg agtcttcctc gtcctcggac tcgatacgcc gcctcatccg 23940 cttttttggg ggcgcccggg gaggcggcgg cgacggggac ggggacgaca cgtcctccat 24000 ggttggggga cgtcgcgccg caccgcgtcc gcgctcgggg gtggtttcgc gctgctcctc 24060

ttcccgactg gccatttcct tctcctatag gcagaaaaag atcatggagt cagtcgagaa 24120 gaaggacagc ctaaccgccc cctctgagtt cgccaccacc gcctccaccg atgccgccaa 24180

cgcgcctacc accttccccg tcgaggcacc cccgcttgag gaggaggaag tgattatcga 24240

gcaggaccca ggttttgtaa gcgaagacga cgaggaccgc tcagtaccaa cagaggataa 24300

aaagcaagac caggacaacg cagaggcaaa cgaggaacaa gtcgggcggg gggacgaaag 24360

gcatggcgac tacctagatg tgggagacga cgtgctgttg aagcatctgc agcgccagtg 24420 cgccattatc tgcgacgcgt tgcaagagcg cagcgatgtg cccctcgcca tagcggatgt 24480

cagccttgcc tacgaacgcc acctattctc accgcgcgta ccccccaaac gccaagaaaa 24540

cggcacatgc gagcccaacc cgcgcctcaa cttctacccc gtatttgccg tgccagaggt 24600 gcttgccacc tatcacatct ttttccaaaa ctgcaagata cccctatcct gccgtgccaa 24660

ccgcagccga gcggacaagc agctggcctt gcggcagggc gctgtcatac ctgatatcgc 24720 ctcgctcaac gaagtgccaa aaatctttga gggtcttgga cgcgacgaga agcgcgcggc 24780 aaacgctctg caacaggaaa acagcgaaaa tgaaagtcac tctggagtgt tggtggaact 24840

cgagggtgac aacgcgcgcc tagccgtact aaaacgcagc atcgaggtca cccactttgc 24900 ctacccggca cttaacctac cccccaaggt catgagcaca gtcatgagtg agctgatcgt 24960 gcgccgtgcg cagcccctgg agagggatgc aaatttgcaa gaacaaacag aggagggcct 25020

acccgcagtt ggcgacgagc agctagcgcg ctggcttcaa acgcgcgagc ctgccgactt 25080 ggaggagcga cgcaaactaa tgatggccgc agtgctcgtt accgtggagc ttgagtgcat 25140

gcagcggttc tttgctgacc cggagatgca gcgcaagcta gaggaaacat tgcactacac 25200 ctttcgacag ggctacgtac gccaggcctg caagatctcc aacgtggagc tctgcaacct 25260 ggtctcctac cttggaattt tgcacgaaaa ccgccttggg caaaacgtgc ttcattccac 25320

gctcaagggc gaggcgcgcc gcgactacgt ccgcgactgc gtttacttat ttctatgcta 25380 Page 213

Sequence_Listing.txt cacctggcag acggccatgg gcgtttggca gcagtgcttg gaggagtgca acctcaagga 25440

gctgcagaaa ctgctaaagc aaaacttgaa ggacctatgg acggccttca acgagcgctc 25500 cgtggccgcg cacctggcgg acatcatttt ccccgaacgc ctgcttaaaa ccctgcaaca 25560

gggtctgcca gacttcacca gtcaaagcat gttgcagaac tttaggaact ttatcctaga 25620 gcgctcagga atcttgcccg ccacctgctg tgcacttcct agcgactttg tgcccattaa 25680 gtaccgcgaa tgccctccgc cgctttgggg ccactgctac cttctgcagc tagccaacta 25740

ccttgcctac cactctgaca taatggaaga cgtgagcggt gacggtctac tggagtgtca 25800 ctgtcgctgc aacctatgca ccccgcaccg ctccctggtt tgcaattcgc agctgcttaa 25860 cgaaagtcaa attatcggta cctttgagct gcagggtccc tcgcctgacg aaaagtccgc 25920

ggctccgggg ttgaaactca ctccggggct gtggacgtcg gcttaccttc gcaaatttgt 25980 acctgaggac taccacgccc acgagattag gttctacgaa gaccaatccc gcccgccaaa 26040 tgcggagctt accgcctgcg tcattaccca gggccacatt cttggccaat tgcaagccat 26100

caacaaagcc cgccaagagt ttctgctacg aaagggacgg ggggtttact tggaccccca 26160 gtccggcgag gagctcaacc caatcccccc gccgccgcag ccctatcagc agcagccgcg 26220

ggcccttgct tcccaggatg gcacccaaaa agaagctgca gctgccgccg ccacccacgg 26280

acgaggagga atactgggac agtcaggcag aggaggtttt ggacgaggag gaggaggaca 26340

tgatggaaga ctgggagagc ctagacgagg aagcttccga ggtcgaagag gtgtcagacg 26400

aaacaccgtc accctcggtc gcattcccct cgccggcgcc ccagaaatcg gcaaccggtt 26460 ccagcatggc tacaacctcc gctcctcagg cgccgccggc actgcccgtt cgccgaccca 26520

accgtagatg ggacaccact ggaaccaggg ccggtaagtc caagcagccg ccgccgttag 26580

cccaagagca acaacagcgc caaggctacc gctcatggcg cgggcacaag aacgccatag 26640 ttgcttgctt gcaagactgt gggggcaaca tctccttcgc ccgccgcttt cttctctacc 26700

atcacggcgt ggccttcccc cgtaacatcc tgcattacta ccgtcatctc tacagcccat 26760 actgcaccgg cggcagcggc agcggcagca acagcagcgg ccacacagaa gcaaaggcga 26820 ccggatagca agactctgac aaagcccaag aaatccacag cggcggcagc agcaggagga 26880

ggagcgctgc gtctggcgcc caacgaaccc gtatcgaccc gcgagcttag aaacaggatt 26940 tttcccactc tgtatgctat atttcaacag agcaggggcc aagaacaaga gctgaaaata 27000 aaaaacaggt ctctgcgatc cctcacccgc agctgcctgt atcacaaaag cgaagatcag 27060

cttcggcgca cgctggaaga cgcggaggct ctcttcagta aatactgcgc gctgactctt 27120 aaggactagt ttcgcgccct ttctcaaatt taagcgcgaa aactacgtca tctccagcgg 27180

ccacacccgg cgccagcacc tgtcgtcagc gccatttcaa ctttgtatac aaaagttgtg 27240 atgagcaagg aaattcccac gccctacatg tggagttacc agccacaaat gggacttgcg 27300 gctggagctg cccaagacta ctcaacccga ataaactaca tgagcgcggg accccacatg 27360

atatcccggg tcaacggaat acgcgcccac cgaaaccgaa ttctcctgga acaggcggct 27420 Page 214

Sequence_Listing.txt attaccacca cacctcgtaa taaccttaat ccccgtagtt ggcccgctgc cctggtgtac 27480

caggaaagtc ccgctcccac cactgtggta cttcccagag acgcccaggc cgaagttcag 27540 atgactaact caggggcgca gcttgcgggc ggctttcgtc acagggtgcg gtcgcccggg 27600

cagggtataa ctcacctgac aatcagaggg cgaggtattc agctcaacga cgagtcggtg 27660 agctcctcgc ttggtctccg tccggacggg acatttcaga tcggcggcgc cggccgctct 27720 tcattcacgc ctcgtcaggc aatcctaact ctgcagacct cgtcctctga gccgcgctct 27780

ggaggcattg gaactctgca atttattgag gagtttgtgc catcggtcta ctttaacccc 27840 ttctcgggac ctcccggcca ctatccggat caatttattc ctaactttga cgcggtaaag 27900 gactcggcgg acggctacga ctgaatgtta agtggagagg cagagcaact gcgcctgaaa 27960

cacctggtcc actgtcgccg ccacaagtgc tttgcccgcg actccggtga gttttgctac 28020 tttgaattgc ccgaggatca tatcgagggc ccggcgcacg gcgtccggct taccgcccag 28080 ggagagcttg cccgtagcct gattcgggag tttacccagc gccccctgct agttgagcgg 28140

gacaggggac cctgtgttct cactgtgatt tgcaactgtc ctaaccctgg attacatcaa 28200 gatctttgtt gccatctctg tgctgagtat aataaataca gaaattaaaa tatactgggg 28260

ctcctatcgc catcctgtaa acgccaccgt cttcacccgc ccaagcaaac caaggcgaac 28320

cttacctggt acttttaaca tctctccctc tgtgatttac aacagtttca acccagacgg 28380

agtgagtcta cgagagaacc tctccgagct cagctactcc atcagaaaaa acaccaccct 28440

ccttacctgc cgggaacgta cgagtgcgtc accggccgct gcaccacacc taccgcctga 28500 ccgtaaacca gactttttcc ggacagacct caataactct gtttaccaga acaggaggtg 28560

agcttagaaa acccttaggg tattaggcca aaggcgcagc tactgtgggg tttatgaaca 28620

attcaagcaa ctctacgggc tattctaatt caggtttctc tagaatcggg gttggggtta 28680 ttctctgtct tgtgattctc tttattctta tactaacgct tctctgccta aggctcgccg 28740

cctgctgtgt gcacatttgc atttattgtc agctttttaa acgctggggt cgccacccaa 28800 gatgattagg tacataatcc taggtttact cacccttgcg tcagcccacg gtaccaccca 28860 aaaggtggat tttaaggagc cagcctgtaa tgttacattc gcagctgaag ctaatgagtg 28920

caccactctt ataaaatgca ccacagaaca tgaaaagctg cttattcgcc acaaaaacaa 28980 aattggcaag tatgctgttt atgctatttg gcagccaggt gacactacag agtataatgt 29040 tacagttttc cagggtaaaa gtcataaaac ttttatgtat acttttccat tttatgaaat 29100

gtgcgacatt accatgtaca tgagcaaaca gtataagttg tggcccccac aaaattgtgt 29160 ggaaaacact ggcactttct gctgcactgc tatgctaatt acagtgctcg ctttggtctg 29220

taccctactc tatattaaat acaaaagcag acgcagcttt attgaggaaa agaaaatgcc 29280 ttaatttact aagttacaaa gctaatgtca ccactaactg ctttactcgc tgcttgcaaa 29340 acaaattcaa aaagttagca ttataattag aataggattt aaaccccccg gtcatttcct 29400

gctcaatacc attcccctga acaattgact ctatgtggga tatgctccag cgctacaacc 29460 Page 215

Sequence_Listing.txt ttgaagtcag gcttcctgga tgtcagcatc tgactttggc cagcacctgt cccgcggatt 29520

tgttccagtc caactacagc gacccaccct aacagagatg accaacacaa ccaacgcggc 29580 cgccgctacc ggacttacat ctaccacaaa tacaccccaa gtttctgcct ttgtcaataa 29640

ctgggataac ttgggcatgt ggtggttctc catagcgctt atgtttgtat gccttattat 29700 tatgtggctc atctgctgcc taaagcgcaa acgcgcccga ccacccatct atagtcccat 29760 cattgtgcta cacccaaaca atgatggaat ccatagattg gacggactga aacacatgtt 29820

cttttctctt acagtatgat taaatgagac atgattcctc gagtttttat attactgacc 29880 cttgttgcgc ttttttgtgc gtgctccaca ttggctgcgg tttctcacat cgaagtagac 29940 tgcattccag ccttcacagt ctatttgctt tacggatttg tcaccctcac gctcatctgc 30000

agcctcatca ctgtggtcat cgcctttatc cagtgcattg actgggtctg tgtgcgcttt 30060 gcatatctca gacaccatcc ccagtacagg gacaggacta tagctgagct tcttagaatt 30120 ctttaattat gaaatttact gtgacttttc tgctgattat ttgcacccta tctgcgtttt 30180

gttccccgac ctccaagcct caaagacata tatcatgcag attcactcgt atatggaata 30240 ttccaagttg ctacaatgaa aaaagcgatc tttccgaagc ctggttatat gcaatcatct 30300

ctgttatggt gttctgcagt accatcttag ccctagctat atatccctac cttgacattg 30360

gctggaacgc aatagatgcc atgaaccacc caactttccc cgcgcccgct atgcttccac 30420

tgcaacaagt tgttgccggc ggctttgtcc cagccaatca gcctcgccca ccttctccca 30480

cccccactga aatcagctac tttaatctaa caggaggaga tgactgacac cctagatcta 30540 gaaatggacg gaattattac agagcagcgc ctgctagaaa gacgcagggc agcggccgag 30600

caacagcgca tgaatcaaga gctccaagac atggttaact tgcaccagtg caaaaggggt 30660

atcttttgtc tggtaaagca ggccaaagtc acctacgaca gtaataccac cggacaccgc 30720 cttagctaca agttgccaac caagcgtcag aaattggtgg tcatggtggg agaaaagccc 30780

attaccataa ctcagcactc ggtagaaacc gaaggctgca ttcactcacc ttgtcaagga 30840 cctgaggatc tctgcaccct tattaagacc ctgtgcggtc tcaaagatct tattcccttt 30900 aactaataaa aaaaaataat aaagcatcac ttacttaaaa tcagttagca aatttctgtc 30960

cagtttattc agcagcacct ccttgccctc ctcccagctc tggtattgca gcttcctcct 31020 ggctgcaaac tttctccaca atctaaatgg aatgtcagtt tcctcctgtt cctgtccatc 31080 cgcacccact atcttcatgt tgttgcagat ggtgagcaaa ggcgaagagc tgttcaccgg 31140

cgtggtgccc atcctggtgg agctggacgg cgacgtgaac ggccacaagt tcagcgtgag 31200 cggcgagggc gagggcgacg ccacctacgg caagctgacc ctgaagctgc tgtgcaccac 31260

cggcaagctg cccgtgccct ggcccaccct ggtgaccacc ctgggctacg gcgtgcagtg 31320 cttcgcccgg taccccgacc acatgaagca gcacgacttc ttcaagagcg ccatgcccga 31380 gggctacgtg caggagcgga ccatcttctt caaggacgac ggcaactaca agacccgggc 31440

cgaggtgaag ttcgagggcg acaccctggt gaaccggatc gagctgaagg gcatcgactt 31500 Page 216

Sequence_Listing.txt caaggaggac ggcaacatcc tgggccacaa gctggagtac aactacaaca gccacaacgt 31560

gtacatcacc gccgacaagc agaagaacgg catcaaggcc aacttcaaga tccggcacaa 31620 catcgaggac ggcggcgtgc agctggccga ccactaccag cagaacaccc ccatcggcga 31680

cggccccgtg ctgctgcccg acaaccacta cctgagctac cagagcgccc tgttcaagga 31740 ccccaacgag aagcgggacc acatggtgct gctggagttc ctgaccgccg ccggcatcac 31800 cgagggcatg aacgagctct ataagggaag cggagctact aacttcagcc tgctgaagca 31860

ggctggtgac gtcgaggaga atcctggccc aatgaagcgc gcaagaccgt ctgaagatac 31920 cttcaacccc gtgtatccat atgacacgga aaccggtcct ccaactgtgc cttttcttac 31980 tcctcccttt gtatccccca atgggtttca agagagtccc cctggggtac tctctttgcg 32040

cctatccgaa cctctagtta cctccaatgg catgcttgcg ctcaaaatgg gcaacggcct 32100 ctctctggac gaggccggca accttacctc ccaaaatgta accactgtga gcccacctct 32160 caaaaaaacc aagtcaaaca taaacctgga aatatctgca cccctcacag ttacctcaga 32220

agccctaact gtggctgccg ccgcacctct aatggtcgcg ggcaacacac tcaccatgca 32280 atcacaggcc ccgctaaccg tgcacgactc caaacttagc attgccaccc aaggacccct 32340

cacagtgtca gaaggaaagc tagccctgca aacatcaggc cccctcacca ccaccgatag 32400

cagtaccctt actatcactg cctcaccccc tctaactact gccactggta gcttgggcat 32460

tgacttgaaa gagcccattt atacacaaaa tggaaaacta ggactaaagt acggggctcc 32520

tttgcatgta acagacgacc taaacacttt gaccgtagca actggtccag gtgtgactat 32580 taataatact tccttgcaaa ctaaagttac tggagccttg ggttttgatt cacaaggcaa 32640

tatgcaactt aatgtagcag gaggactaag gattgattct caaaacagac gccttatact 32700

tgatgttagt tatccgtttg atgctcaaaa ccaactaaat ctaagactag gacagggccc 32760 tctttttata aactcagccc acaacttgga tattaactac aacaaaggcc tttacttgtt 32820

tacagcttca aacaattcca aaaagcttga ggttaaccta agcactgcca aggggttgat 32880 gtttgacgct acagccatag ccattaatgc aggagatggg cttgaatttg gttcacctaa 32940 tgcaccaaac acaaatcccc tcaaaacaaa aattggccat ggcctagaat ttgattcaaa 33000

caaggctatg gttcctaaac taggaactgg ccttagtttt gacagcacag gtgccattac 33060 agtaggaaac aaaaataatg ataagctaac tttgtggacc acaccagctc catctcctaa 33120 ctgtagacta aatgcagaga aagatgctaa actcactttg gtcttaacaa aatgtggcag 33180

tcaaatactt gctacagttt cagttttggc tgttaaaggc agtttggctc caatatctgg 33240 aacagttcaa agtgctcatc ttattataag atttgacgaa aatggagtgc tactaaacaa 33300

ttccttcctg gacccagaat attggaactt tagaaatgga gatcttactg aaggcacagc 33360 ctatacaaac gctgttggat ttatgcctaa cctatcagct tatccaaaat ctcacggtaa 33420 aactgccaaa agtaacattg tcagtcaagt ttacttaaac ggagacaaaa ctaaacctgt 33480

aacactaacc attacactaa acggtacaca ggaaacagga gacacaactc caagtgcata 33540 Page 217

Sequence_Listing.txt ctctatgtca ttttcatggg actggtctgg ccacaactac attaatgaaa tatttgccac 33600

atcctcttac actttttcat acattgccca agaataaaga atcgtttgtg ttatgtttca 33660 acgtgtttat ttttcaattg cagaaaattt cgaatcattt ttcattcagt agtatagccc 33720

caccaccaca tagcttatac agatcaccgt acctctttat ttttcaattg cagaaaattt 33780 caagtcattt ttcattcagt agtatagccc caccaccaca tagcttatac agatcaccgt 33840 acctcaactt tgtataataa agttgtaatc aaactcacag aaccctagta ttcaacctgc 33900

cacctccctc ccaacacaca gagtacacag tcctttctcc ccggctggcc ttaaaaagca 33960 tcatatcatg ggtaacagac atattcttag gtgttatatt ccacacggtt tcctgtcgag 34020 ccaaacgctc atcagtgata ttaataaact ccccgggcag ctcacttaag ttcatgtcgc 34080

tgtccagctg ctgagccaca ggctgctgtc caacttgcgg ttgcttaacg ggcggcgaag 34140 gagaagtcca cgcctacatg ggggtagagt cataatcgtg catcaggata gggcggtggt 34200 gctgcagcag cgcgcgaata aactgctgcc gccgccgctc cgtcctgcag gaatacaaca 34260

tggcagtggt ctcctcagcg atgattcgca ccgcccgcag cataaggcgc cttgtcctcc 34320 gggcacagca gcgcaccctg atctcactta aatcagcaca gtaactgcag cacagcacca 34380

caatattgtt caaaatccca cagtgcaagg cgctgtatcc aaagctcatg gcggggacca 34440

cagaacccac gtggccatca taccacaagc gcaggtagat taagtggcga cccctcataa 34500

acacgctgga cataaacatt acctcttttg gcatgttgta attcaccacc tcccggtacc 34560

atataaacct ctgattaaac atggcgccat ccaccaccat cctaaaccag ctggccaaaa 34620 cctgcccgcc ggctatacac tgcagggaac cgggactgga acaatgacag tggagagccc 34680

aggactcgta accatggatc atcatgctcg tcatgatatc aatgttggca caacacaggc 34740

acacgtgcat acacttcctc aggattacaa gctcctcccg cgttagaacc atatcccagg 34800 gaacaaccca ttcctgaatc agcgtaaatc ccacactgca gggaagacct cgcacgtaac 34860

tcacgttgtg cattgtcaaa gtgttacatt cgggcagcag cggatgatcc tccagtatgg 34920 tagcgcgggt ttctgtctca aaaggaggta gacgatccct actgtacgga gtgcgccgag 34980 acaaccgaga tcgtgttggt cgtagtgtca tgccaaatgg aacgccggac gtagtcatat 35040

ttcctgaagc aaaaccaggt gcgggcgtga caaacagatc tgcgtctccg gtctcgccgc 35100 ttagatcgct ctgtgtagta gttgtagtat atccactctc tcaaagcatc caggcgcccc 35160 ctggcttcgg gttctatgta aactccttca tgcgccgctg ccctgataac atccaccacc 35220

gcagaataag ccacacccag ccaacctaca cattcgttct gcgagtcaca cacgggagga 35280 gcgggaagag ctggaagaac catgtttttt tttttattcc aaaagattat ccaaaacctc 35340

aaaatgaaga tctattaagt gaacgcgctc ccctccggtg gcgtggtcaa actctacagc 35400 caaagaacag ataatggcat ttgtaagatg ttgcacaatg gcttccaaaa ggcaaacggc 35460 cctcacgtcc aagtggacgt aaaggctaaa cccttcaggg tgaatctcct ctataaacat 35520

tccagcacct tcaaccatgc ccaaataatt ctcatctcgc caccttctca atatatctct 35580 Page 218

Sequence_Listing.txt aagcaaatcc cgaatattaa gtccggccat tgtaaaaatc tgctccagag cgccctccac 35640

cttcagcctc aagcagcgaa tcatgattgc aaaaattcag gttcctcaca gacctgtata 35700 agattcaaaa gcggaacatt aacaaaaata ccgcgatccc gtaggtccct tcgcagggcc 35760

agctgaacat aatcgtgcag gtctgcacgg accagcgcgg ccacttcccc gccaggaacc 35820 atgacaaaag aacccacact gattatgaca cgcatactcg gagctatgct aaccagcgta 35880 gccccgatgt aagcttgttg catgggcggc gatataaaat gcaaggtgct gctcaaaaaa 35940

tcaggcaaag cctcgcgcaa aaaagaaagc acatcgtagt catgctcatg cagataaagg 36000 caggtaagct ccggaaccac cacagaaaaa gacaccattt ttctctcaaa catgtctgcg 36060 ggtttctgca taaacacaaa ataaaataac aaaaaaacat ttaaacatta gaagcctgtc 36120

ttacaacagg aaaaacaacc cttataagca taagacggac tacggccatg ccggcgtgac 36180 cgtaaaaaaa ctggtcaccg tgattaaaaa gcaccaccga cagctcctcg gtcatgtccg 36240 gagtcataat gtaagactcg gtaaacacat caggttgatt cacatcggtc agtgctaaaa 36300

agcgaccgaa atagcccggg ggaatacata cccgcaggcg tagagacaac attacagccc 36360 ccataggagg tataacaaaa ttaataggag agaaaaacac ataaacacct gaaaaaccct 36420

cctgcctagg caaaatagca ccctcccgct ccagaacaac atacagcgct tccacagcgg 36480

cagccataac agtcagcctt accagtaaaa aagaaaacct attaaaaaaa caccactcga 36540

cacggcacca gctcaatcag tcacagtgta aaaaagggcc aagtgcagag cgagtatata 36600

taggactaaa aaatgacgta acggttaaag tccacaaaaa acacccagaa aaccgcacgc 36660 gaacctacgc ccagaaacga aagccaaaaa acccacaact tcctcaaatc gtcacttccg 36720

ttttcccacg ttacgtcact tcccatttta agaaaactac aattcccaac acatacaagt 36780

tactccgccc taaaacctac gtcacccgcc ccgttcccac gccccgcgcc acgtcacaaa 36840 ctccaccccc tcattatcat attggcttca atccaaaata aggtatatta ttgatgatg 36899

<210> 13 <211> 36794 <212> DNA <213> Artificial Sequence

<220> <223> Synthetic adenovirus genome Fiber-P2A-YPet

<400> 13 catcatcaat aatatacctt attttggatt gaagccaata tgataatgag ggggtggagt 60

ttgtgacgtg gcgcggggcg tgggaacggg gcgggtgacg tagtagtgtg gcggaagtgt 120 gatgttgcaa gtgtggcgga acacatgtaa gcgacggatg tggcaaaagt gacgtttttg 180

gtgtgcgccg gtgtacacag gaagtgacaa ttttcgcgcg gttttaggcg gatgttgtag 240 taaatttggg cgtaaccgag taagatttgg ccattttcgc gggaaaactg aataagagga 300 agtgaaatct gaataatttt gtgttactca tagcgcgtaa tatttgtcta gggccgcggg 360

gactttgacc gtttacgtgg agactcgccc aggtgttttt ctcaggtgtt ttccgcgttc 420 Page 219

Sequence_Listing.txt cgggtcaaag ttggcgtttt attattatag tcagctgacg tgtagtgtat ttatacccgg 480

tgagttcctc aagaggccac tcttgagtgc cagcgagtag agttttctcc tccgagccgc 540 tccgacaccg ggactgaaaa tgagacatat tatctgccac ggaggtgtta ttaccgaaga 600

aatggccgcc agtcttttgg accagctgat cgaagaggta ctggctgata atcttccacc 660 tcctagccat tttgaaccac ctacccttca cgaactgtat gatttagacg tgacggcccc 720 cgaagatccc aacgaggagg cggtttcgca gatttttccc gactctgtaa tgttggcggt 780

gcaggaaggg attgacttac tcacttttcc gccggcgccc ggttctccgg agccgcctca 840 cctttcccgg cagcccgagc agccggagca gagagccttg ggtccggttt ctatgccaaa 900 ccttgtaccg gaggtgatcg atcttacctg ccacgaggct ggctttccac ccagtgacga 960

cgaggatgaa gagggtgagg agtttgtgtt agattatgtg gagcaccccg ggcacggttg 1020 caggtcttgt cattatcacc ggaggaatac gggggaccca gatattatgt gttcgctttg 1080 ctatatgagg acctgtggca tgtttgtcta cagtaagtga aaattatggg cagtgggtga 1140

tagagtggtg ggtttggtgt ggtaattttt tttttaattt ttacagtttt gtggtttaaa 1200 gaattttgta ttgtgatttt tttaaaaggt cctgtgtctg aacctgagcc tgagcccgag 1260

ccagaaccgg agcctgcaag acctacccgc cgtcctaaaa tggcgcctgc tatcctgaga 1320

cgcccgacat cacctgtgtc tagagaatgc aatagtagta cggatagctg tgactccggt 1380

ccttctaaca cacctcctga gatacacccg gtggtcccgc tgtgccccat taaaccagtt 1440

gccgtgagag ttggtgggcg tcgccaggct gtggaatgta tcgaggactt gcttaacgag 1500 cctgggcaac ctttggactt gagctgtaaa cgccccaggc cataaggtgt aaacctgtga 1560

ttgcgtgtgt ggttaacgcc tttgtttgct gaatgagttg atgtaagttt aataaagggt 1620

gagataatgt ttaacttgca tggcgtgtta aatggggcgg ggcttaaagg gtatataatg 1680 cgccgtgggc taatcttggt tacatctgac ctcatggagg cttgggagtg tttggaagat 1740

ttttctgctg tgcgtaactt gctggaacag agctctaaca gtacctcttg gttttggagg 1800 tttctgtggg gctcatccca ggcaaagtta gtctgcagaa ttaaggagga ttacaagtgg 1860 gaatttgaag agcttttgaa atcctgtggt gagctgtttg attctttgaa tctgggtcac 1920

caggcgcttt tccaagagaa ggtcatcaag actttggatt tttccacacc ggggcgcgct 1980 gcggctgctg ttgctttttt gagttttata aaggataaat ggagcgaaga aacccatctg 2040 agcggggggt acctgctgga ttttctggcc atgcatctgt ggagagcggt tgtgagacac 2100

aagaatcgcc tgctactgtt gtcttccgtc cgcccggcga taataccgac ggaggagcag 2160 cagcagcagc aggaggaagc caggcggcgg cggcaggagc agagcccatg gaacccgaga 2220

gccggcctgg accctcggga atgaatgttg tacaggtggc tgaactgtat ccagaactga 2280 gacgcatttt gacaattaca gaggatgggc aggggctaaa gggggtaaag agggagcggg 2340 gggcttgtga ggctacagag gaggctagga atctagcttt tagcttaatg accagacacc 2400

gtcctgagtg tattactttt caacagatca aggataattg cgctaatgag cttgatctgc 2460 Page 220

Sequence_Listing.txt tggcgcagaa gtattccata gagcagctga ccacttactg gctgcagcca ggggatgatt 2520

ttgaggaggc tattagggta tatgcaaagg tggcacttag gccagattgc aagtacaaga 2580 tcagcaaact tgtaaatatc aggaattgtt gctacatttc tgggaacggg gccgaggtgg 2640

agatagatac ggaggatagg gtggccttta gatgtagcat gataaatatg tggccggggg 2700 tgcttggcat ggacggggtg gttattatga atgtaaggtt tactggcccc aattttagcg 2760 gtacggtttt cctggccaat accaacctta tcctacacgg tgtaagcttc tatgggttta 2820

acaatacctg tgtggaagcc tggaccgatg taagggttcg gggctgtgcc ttttactgct 2880 gctggaaggg ggtggtgtgt cgccccaaaa gcagggcttc aattaagaaa tgcctctttg 2940 aaaggtgtac cttgggtatc ctgtctgagg gtaactccag ggtgcgccac aatgtggcct 3000

ccgactgtgg ttgcttcatg ctagtgaaaa gcgtggctgt gattaagcat aacatggtat 3060 gtggcaactg cgaggacagg gcctctcaga tgctgacctg ctcggacggc aactgtcacc 3120 tgctgaagac cattcacgta gccagccact ctcgcaaggc ctggccagtg tttgagcata 3180

acatactgac ccgctgttcc ttgcatttgg gtaacaggag gggggtgttc ctaccttacc 3240 aatgcaattt gagtcacact aagatattgc ttgagcccga gagcatgtcc aaggtgaacc 3300

tgaacggggt gtttgacatg accatgaaga tctggaaggt gctgaggtac gatgagaccc 3360

gcaccaggtg cagaccctgc gagtgtggcg gtaaacatat taggaaccag cctgtgatgc 3420

tggatgtgac cgaggagctg aggcccgatc acttggtgct ggcctgcacc cgcgctgagt 3480

ttggctctag cgatgaagat acagattgag gtactgaaat gtgtgggcgt ggcttaaggg 3540 tgggaaagaa tatataaggt gggggtctta tgtagttttg tatctgtttt gcagcagccg 3600

ccgccgccca acttttctat acaaagttgt aatgagcacc aactcgtttg atggaagcat 3660

tgtgagctca tatttgacaa cgcgcatgcc cccatgggcc ggggtgcgtc agaatgtgat 3720 gggctccagc attgatggtc gccccgtcct gcccgcaaac tctactacct tgacctacga 3780

gaccgtgtct ggaacgccgt tggagactgc agcctccgcc gccgcttcag ccgctgcagc 3840 caccgcccgc gggattgtga ctgactttgc tttcctgagc ccgcttgcaa gcagtgcagc 3900 ttcccgttca tccgcccgcg atgacaagtt gacggctctt ttggcacaat tggattcttt 3960

gacccgggaa cttaatgtcg tttctcagca gctgttggat ctgcgccagc aggtttctgc 4020 cctgaaggct tcctcccctc ccaatgcggt ttaaaacata aataaaaaac cagactctgt 4080 ttggatttgg atcaagcata agtgtcttgc tgtctttatt taggggtttt gcgcgcgcgg 4140

taggcccggg accagcggtc tcggtcgttg agggtcctgt gtattttttc caggacgtgg 4200 taaaggtgac tctggatgtt cagatacatg ggcataagcc cgtctctggg gtggaggtag 4260

caccactgca gagcttcatg ctgcggggtg gtgttgtaga tgatccagtc gtagcaggag 4320 cgctgggcgt ggtgcctaaa aatgtctttc agtagcaagc tgattgccag gggcaggccc 4380 ttggtgtaag tgtttacaaa gcggttaagc tgggatgggt gcatacgtgg ggatatgaga 4440

tgcatcttgg actgtatttt taggttggct atgttcccag ccatatccct ccggggattc 4500 Page 221

Sequence_Listing.txt atgttgtgca gaaccaccag cacagtgtat ccggtgcact tgggaaattt gtcatgtagc 4560

ttagaaggaa atgcgtggaa gaacttggag acgcccttgt gacctccaag attttccatg 4620 cattcgtcca taatgatggc aatgggccca cgggcggcgg cctgggcgaa gatatttctg 4680

ggatcactaa cgtcatagtt gtgttccagg atgagatcgt cataggccat ttttacaaag 4740 cgcgggcgga gggtgccaga ctgcggtata atggttccat ccggcccagg ggcgtagtta 4800 ccctcacaga tttgcatttc ccacgctttg agttcagatg gggggatcat gtctacctgc 4860

ggggcgatga agaaaacggt ttccggggta ggggagatca gctgggaaga aagcaggttc 4920 ctgagcagct gcgacttacc gcagccggtg ggcccgtaaa tcacacctat taccgggtgc 4980 aactggtagt taagagagct gcagctgccg tcatccctga gcaggggggc cacttcgtta 5040

agcatgtccc tgactcgcat gttttccctg accaaatccg ccagaaggcg ctcgccgccc 5100 agcgatagca gttcttgcaa ggaagcaaag tttttcaacg gtttgagacc gtccgccgta 5160 ggcatgcttt tgagcgtttg accaagcagt tccaggcggt cccacagctc ggtcacctgc 5220

tctacggcat ctcgatccag catatctcct cgtttcgcgg gttggggcgg ctttcgctgt 5280 acggcagtag tcggtgctcg tccagacggg ccagggtcat gtctttccac gggcgcaggg 5340

tcctcgtcag cgtagtctgg gtcacggtga aggggtgcgc tccgggctgc gcgctggcca 5400

gggtgcgctt gaggctggtc ctgctggtgc tgaagcgctg ccggtcttcg ccctgcgcgt 5460

cggccaggta gcatttgacc atggtgtcat agtccagccc ctccgcggcg tggcccttgg 5520

cgcgcagctt gcccttggag gaggcgccgc acgaggggca gtgcagactt ttgagggcgt 5580 agagcttggg cgcgagaaat accgattccg gggagtaggc atccgcgccg caggccccgc 5640

agacggtctc gcattccacg agccaggtga gctctggccg ttcggggtca aaaaccaggt 5700

ttcccccatg ctttttgatg cgtttcttac ctctggtttc catgagccgg tgtccacgct 5760 cggtgacgaa aaggctgtcc gtgtccccgt atacagactt gagaggcctg tcctcgagcg 5820

gtgttccgcg gtcctcctcg tatagaaact cggaccactc tgagacaaag gctcgcgtcc 5880 aggccagcac gaaggaggct aagtgggagg ggtagcggtc gttgtccact agggggtcca 5940 ctcgctccag ggtgtgaaga cacatgtcgc cctcttcggc atcaaggaag gtgattggtt 6000

tgtaggtgta ggccacgtga ccgggtgttc ctgaaggggg gctataaaag ggggtggggg 6060 cgcgttcgtc ctcactctct tccgcatcgc tgtctgcgag ggccagctgt tggggtgagt 6120 actccctctg aaaagcgggc atgacttctg cgctaagatt gtcagtttcc aaaaacgagg 6180

aggatttgat attcacctgg cccgcggtga tgcctttgag ggtggccgca tccatctggt 6240 cagaaaagac aatctttttg ttgtcaagct tggtggcaaa cgacccgtag agggcgttgg 6300

acagcaactt ggcgatggag cgcagggttt ggtttttgtc gcgatcggcg cgctccttgg 6360 ccgcgatgtt tagctgcacg tattcgcgcg caacgcaccg ccattcggga aagacggtgg 6420 tgcgctcgtc gggcaccagg tgcacgcgcc aaccgcggtt gtgcagggtg acaaggtcaa 6480

cgctggtggc tacctctccg cgtaggcgct cgttggtcca gcagaggcgg ccgcccttgc 6540 Page 222

Sequence_Listing.txt gcgagcagaa tggcggtagg gggtctagct gcgtctcgtc cggggggtct gcgtccacgg 6600

taaagacccc gggcagcagg cgcgcgtcga agtagtctat cttgcatcct tgcaagtcta 6660 gcgcctgctg ccatgcgcgg gcggcaagcg cgcgctcgta tgggttgagt gggggacccc 6720

atggcatggg gtgggtgagc gcggaggcgt acatgccgca aatgtcgtaa acgtagaggg 6780 gctctctgag tattccaaga tatgtagggt agcatcttcc accgcggatg ctggcgcgca 6840 cgtaatcgta tagttcgtgc gagggagcga ggaggtcggg accgaggttg ctacgggcgg 6900

gctgctctgc tcggaagact atctgcctga agatggcatg tgagttggat gatatggttg 6960 gacgctggaa gacgttgaag ctggcgtctg tgagacctac cgcgtcacgc acgaaggagg 7020 cgtaggagtc gcgcagcttg ttgaccagct cggcggtgac ctgcacgtct agggcgcagt 7080

agtccagggt ttccttgatg atgtcatact tatcctgtcc cttttttttc cacagctcgc 7140 ggttgaggac aaactcttcg cggtctttcc agtactcttg gatcggaaac ccgtcggcct 7200 ccgaacggta agagcctagc atgtagaact ggttgacggc ctggtaggcg cagcatccct 7260

tttctacggg tagcgcgtat gcctgcgcgg ccttccggag cgaggtgtgg gtgagcgcaa 7320 aggtgtccct gaccatgact ttgaggtact ggtatttgaa gtcagtgtcg tcgcatccgc 7380

cctgctccca gagcaaaaag tccgtgcgct ttttggaacg cggatttggc agggcgaagg 7440

tgacatcgtt gaagagtatc tttcccgcgc gaggcataaa gttgcgtgtg atgcggaagg 7500

gtcccggcac ctcggaacgg ttgttaatta cctgggcggc gagcacgatc tcgtcaaagc 7560

cgttgatgtt gtggcccaca atgtaaagtt ccaagaagcg cgggatgccc ttgatggaag 7620 gcaatttttt aagttcctcg taggtgagct cttcagggga gctgagcccg tgctctgaaa 7680

gggcccagtc tgcaagatga gggttggaag cgacgaatga gctccacagg tcacgggcca 7740

ttagcatttg caggtggtcg cgaaaggtcc taaactggcg acctatggcc attttttctg 7800 gggtgatgca gtagaaggta agcgggtctt gttcccagcg gtcccatcca aggttcgcgg 7860

ctaggtctcg cgcggcagtc actagaggct catctccgcc gaacttcatg accagcatga 7920 agggcacgag ctgcttccca aaggccccca tccaagtata ggtctctaca tcgtaggtga 7980 caaagagacg ctcggtgcga ggatgcgagc cgatcgggaa gaactggatc tcccgccacc 8040

aattggagga gtggctattg atgtggtgaa agtagaagtc cctgcgacgg gccgaacact 8100 cgtgctggct tttgtaaaaa cgtgcgcagt actggcagcg gtgcacgggc tgtacatcct 8160 gcacgaggtt gacctgacga ccgcgcacaa ggaagcagag tgggaatttg agcccctcgc 8220

ctggcgggtt tggctggtgg tcttctactt cggctgcttg tccttgaccg tctggctgct 8280 cgaggggagt tacggtggat cggaccacca cgccgcgcga gcccaaagtc cagatgtccg 8340

cgcgcggcgg tcggagcttg atgacaacat cgcgcagatg ggagctgtcc atggtctgga 8400 gctcccgcgg cgtcaggtca ggcgggagct cctgcaggtt tacctcgcat agacgggtca 8460 gggcgcgggc tagatccagg tgatacctaa tttccagggg ctggttggtg gcggcgtcga 8520

tggcttgcaa gaggccgcat ccccgcggcg cgactacggt accgcgcggc gggcggtggg 8580 Page 223

Sequence_Listing.txt ccgcgggggt gtccttggat gatgcatcta aaagcggtga cgcgggcgag cccccggagg 8640

tagggggggc tccggacccg ccgggagagg gggcaggggc acgtcggcgc cgcgcgcggg 8700 caggagctgg tgctgcgcgc gtaggttgct ggcgaacgcg acgacgcggc ggttgatctc 8760

ctgaatctgg cgcctctgcg tgaagacgac gggcccggtg agcttgagcc tgaaagagag 8820 ttcgacagaa tcaatttcgg tgtcgttgac ggcggcctgg cgcaaaatct cctgcacgtc 8880 tcctgagttg tcttgatagg cgatctcggc catgaactgc tcgatctctt cctcctggag 8940

atctccgcgt ccggctcgct ccacggtggc ggcgaggtcg ttggaaatgc gggccatgag 9000 ctgcgagaag gcgttgaggc ctccctcgtt ccagacgcgg ctgtagacca cgcccccttc 9060 ggcatcgcgg gcgcgcatga ccacctgcgc gagattgagc tccacgtgcc gggcgaagac 9120

ggcgtagttt cgcaggcgct gaaagaggta gttgagggtg gtggcggtgt gttctgccac 9180 gaagaagtac ataacccagc gtcgcaacgt ggattcgttg atatccccca aggcctcaag 9240 gcgctccatg gcctcgtaga agtccacggc gaagttgaaa aactgggagt tgcgcgccga 9300

cacggttaac tcctcctcca gaagacggat gagctcggcg acagtgtcgc gcacctcgcg 9360 ctcaaaggct acaggggcct cttcttcttc ttcaatctcc tcttccataa gggcctcccc 9420

ttcttcttct tctggcggcg gtgggggagg ggggacacgg cggcgacgac ggcgcaccgg 9480

gaggcggtcg acaaagcgct cgatcatctc cccgcggcga cggcgcatgg tctcggtgac 9540

ggcgcggccg ttctcgcggg ggcgcagttg gaagacgccg cccgtcatgt cccggttatg 9600

ggttggcggg gggctgccat gcggcaggga tacggcgcta acgatgcatc tcaacaattg 9660 ttgtgtaggt actccgccgc cgagggacct gagcgagtcc gcatcgaccg gatcggaaaa 9720

cctctcgaga aaggcgtcta accagtcaca gtcgcaaggt aggctgagca ccgtggcggg 9780

cggcagcggg cggcggtcgg ggttgtttct ggcggaggtg ctgctgatga tgtaattaaa 9840 gtaggcggtc ttgagacggc ggatggtcga cagaagcacc atgtccttgg gtccggcctg 9900

ctgaatgcgc aggcggtcgg ccatgcccca ggcttcgttt tgacatcggc gcaggtcttt 9960 gtagtagtct tgcatgagcc tttctaccgg cacttcttct tctccttcct cttgtcctgc 10020 atctcttgca tctatcgctg cggcggcggc ggagtttggc cgtaggtggc gccctcttcc 10080

tcccatgcgt gtgaccccga agcccctcat cggctgaagc agggctaggt cggcgacaac 10140 gcgctcggct aatatggcct gctgcacctg cgtgagggta gactggaagt catccatgtc 10200 cacaaagcgg tggtatgcgc ccgtgttgat ggtgtaagtg cagttggcca taacggacca 10260

gttaacggtc tggtgacccg gctgcgagag ctcggtgtac ctgagacgcg agtaagccct 10320 cgagtcaaat acgtagtcgt tgcaagtccg caccaggtac tggtatccca ccaaaaagtg 10380

cggcggcggc tggcggtaga ggggccagcg tagggtggcc ggggctccgg gggcgagatc 10440 ttccaacata aggcgatgat atccgtagat gtacctggac atccaggtga tgccggcggc 10500 ggtggtggag gcgcgcggaa agtcgcggac gcggttccag atgttgcgca gcggcaaaaa 10560

gtgctccatg gtcgggacgc tctggccggt caggcgcgcg caatcgttga cgctctagac 10620 Page 224

Sequence_Listing.txt cgtgcaaaag gagagcctgt aagcgggcac tcttccgtgg tctggtggat aaattcgcaa 10680

gggtatcatg gcggacgacc ggggttcgag ccccgtatcc ggccgtccgc cgtgatccat 10740 gcggttaccg cccgcgtgtc gaacccaggt gtgcgacgtc agacaacggg ggagtgctcc 10800

ttttggcttc cttccaggcg cggcggctgc tgcgctagct tttttggcca ctggccgcgc 10860 gcagcgtaag cggttaggct ggaaagcgaa agcattaagt ggctcgctcc ctgtagccgg 10920 agggttattt tccaagggtt gagtcgcggg acccccggtt cgagtctcgg accggccgga 10980

ctgcggcgaa cgggggtttg cctccccgtc atgcaagacc ccgcttgcaa attcctccgg 11040 aaacagggac gagccccttt tttgcttttc ccagatgcat ccggtgctgc ggcagatgcg 11100 cccccctcct cagcagcggc aagagcaaga gcagcggcag acatgcaggg caccctcccc 11160

tcctcctacc gcgtcaggag gggcgacatc cgcggttgac gcggcagcag atggtgatta 11220 cgaacccccg cggcgccggg cccggcacta cctggacttg gaggagggcg agggcctggc 11280 gcggctagga gcgccctctc ctgagcggta cccaagggtg cagctgaagc gtgatacgcg 11340

tgaggcgtac gtgccgcggc agaacctgtt tcgcgaccgc gagggagagg agcccgagga 11400 gatgcgggat cgaaagttcc acgcagggcg cgagctgcgg catggcctga atcgcgagcg 11460

gttgctgcgc gaggaggact ttgagcccga cgcgcgaacc gggattagtc ccgcgcgcgc 11520

acacgtggcg gccgccgacc tggtaaccgc atacgagcag acggtgaacc aggagattaa 11580

ctttcaaaaa agctttaaca accacgtgcg tacgcttgtg gcgcgcgagg aggtggctat 11640

aggactgatg catctgtggg actttgtaag cgcgctggag caaaacccaa atagcaagcc 11700 gctcatggcg cagctgttcc ttatagtgca gcacagcagg gacaacgagg cattcaggga 11760

tgcgctgcta aacatagtag agcccgaggg ccgctggctg ctcgatttga taaacatcct 11820

gcagagcata gtggtgcagg agcgcagctt gagcctggct gacaaggtgg ccgccatcaa 11880 ctattccatg cttagcctgg gcaagtttta cgcccgcaag atataccata ccccttacgt 11940

tcccatagac aaggaggtaa agatcgaggg gttctacatg cgcatggcgc tgaaggtgct 12000 taccttgagc gacgacctgg gcgtttatcg caacgagcgc atccacaagg ccgtgagcgt 12060 gagccggcgg cgcgagctca gcgaccgcga gctgatgcac agcctgcaaa gggccctggc 12120

tggcacgggc agcggcgata gagaggccga gtcctacttt gacgcgggcg ctgacctgcg 12180 ctgggcccca agccgacgcg ccctggaggc agctggggcc ggacctgggc tggcggtggc 12240 acccgcgcgc gctggcaacg tcggcggcgt ggaggaatat gacgaggacg atgagtacga 12300

gccagaggac ggcgagtact aagcggtgat gtttctgatc agatgatgca agacgcaacg 12360 gacccggcgg tgcgggcggc gctgcagagc cagccgtccg gccttaactc cacggacgac 12420

tggcgccagg tcatggaccg catcatgtcg ctgactgcgc gcaatcctga cgcgttccgg 12480 cagcagccgc aggccaaccg gctctccgca attctggaag cggtggtccc ggcgcgcgca 12540 aaccccacgc acgagaaggt gctggcgatc gtaaacgcgc tggccgaaaa cagggccatc 12600

cggcccgacg aggccggcct ggtctacgac gcgctgcttc agcgcgtggc tcgttacaac 12660 Page 225

Sequence_Listing.txt agcggcaacg tgcagaccaa cctggaccgg ctggtggggg atgtgcgcga ggccgtggcg 12720

cagcgtgagc gcgcgcagca gcagggcaac ctgggctcca tggttgcact aaacgccttc 12780 ctgagtacac agcccgccaa cgtgccgcgg ggacaggagg actacaccaa ctttgtgagc 12840

gcactgcggc taatggtgac tgagacaccg caaagtgagg tgtaccagtc tgggccagac 12900 tattttttcc agaccagtag acaaggcctg cagaccgtaa acctgagcca ggctttcaaa 12960 aacttgcagg ggctgtgggg ggtgcgggct cccacaggcg accgcgcgac cgtgtctagc 13020

ttgctgacgc ccaactcgcg cctgttgctg ctgctaatag cgcccttcac ggacagtggc 13080 agcgtgtccc gggacacata cctaggtcac ttgctgacac tgtaccgcga ggccataggt 13140 caggcgcatg tggacgagca tactttccag gagattacaa gtgtcagccg cgcgctgggg 13200

caggaggaca cgggcagcct ggaggcaacc ctaaactacc tgctgaccaa ccggcggcag 13260 aagatcccct cgttgcacag tttaaacagc gaggaggagc gcattttgcg ctacgtgcag 13320 cagagcgtga gccttaacct gatgcgcgac ggggtaacgc ccagcgtggc gctggacatg 13380

accgcgcgca acatggaacc gggcatgtat gcctcaaacc ggccgtttat caaccgccta 13440 atggactact tgcatcgcgc ggccgccgtg aaccccgagt atttcaccaa tgccatcttg 13500

aacccgcact ggctaccgcc ccctggtttc tacaccgggg gattcgaggt gcccgagggt 13560

aacgatggat tcctctggga cgacatagac gacagcgtgt tttccccgca accgcagacc 13620

ctgctagagt tgcaacagcg cgagcaggca gaggcggcgc tgcgaaagga aagcttccgc 13680

aggccaagca gcttgtccga tctaggcgct gcggccccgc ggtcagatgc tagtagccca 13740 tttccaagct tgatagggtc tcttaccagc actcgcacca cccgcccgcg cctgctgggc 13800

gaggaggagt acctaaacaa ctcgctgctg cagccgcagc gcgaaaaaaa cctgcctccg 13860

gcatttccca acaacgggat agagagccta gtggacaaga tgagtagatg gaagacgtac 13920 gcgcaggagc acagggacgt gccaggcccg cgcccgccca cccgtcgtca aaggcacgac 13980

cgtcagcggg gtctggtgtg ggaggacgat gactcggcag acgacagcag cgtcctggat 14040 ttgggaggga gtggcaaccc gtttgcgcac cttcgcccca ggctggggag aatgttttaa 14100 aaaaaaaaaa gcatgatgca aaataaaaaa ctcaccaagg ccatggcacc gagcgttggt 14160

tttcttgtat tccccttagt atgcggcgcg cggcgatgta tgaggaaggt cctcctccct 14220 cctacgagag tgtggtgagc gcggcgccag tggcggcggc gctgggttct cccttcgatg 14280 ctcccctgga cccgccgttt gtgcctccgc ggtacctgcg gcctaccggg gggagaaaca 14340

gcatccgtta ctctgagttg gcacccctat tcgacaccac ccgtgtgtac ctggtggaca 14400 acaagtcaac ggatgtggca tccctgaact accagaacga ccacagcaac tttctgacca 14460

cggtcattca aaacaatgac tacagcccgg gggaggcaag cacacagacc atcaatcttg 14520 acgaccggtc gcactggggc ggcgacctga aaaccatcct gcataccaac atgccaaatg 14580 tgaacgagtt catgtttacc aataagttta aggcgcgggt gatggtgtcg cgcttgccta 14640

ctaaggacaa tcaggtggag ctgaaatacg agtgggtgga gttcacgctg cccgagggca 14700 Page 226

Sequence_Listing.txt actactccga gaccatgacc atagacctta tgaacaacgc gatcgtggag cactacttga 14760

aagtgggcag acagaacggg gttctggaaa gcgacatcgg ggtaaagttt gacacccgca 14820 acttcagact ggggtttgac cccgtcactg gtcttgtcat gcctggggta tatacaaacg 14880

aagccttcca tccagacatc attttgctgc caggatgcgg ggtggacttc acccacagcc 14940 gcctgagcaa cttgttgggc atccgcaagc ggcaaccctt ccaggagggc tttaggatca 15000 cctacgatga tctggagggt ggtaacattc ccgcactgtt ggatgtggac gcctaccagg 15060

cgagcttgaa agatgacacc gaacagggcg ggggtggcgc aggcggcagc aacagcagtg 15120 gcagcggcgc ggaagagaac tccaacgcgg cagccgcggc aatgcagccg gtggaggaca 15180 tgaacgatca tgccattcgc ggcgacacct ttgccacacg ggctgaggag aagcgcgctg 15240

aggccgaagc agcggccgaa gctgccgccc ccgctgcgca acccgaggtc gagaagcctc 15300 agaagaaacc ggtgatcaaa cccctgacag aggacagcaa gaaacgcagt tacaacctaa 15360 taagcaatga cagcaccttc acccagtacc gcagctggta ccttgcatac aactacggcg 15420

accctcagac cggaatccgc tcatggaccc tgctttgcac tcctgacgta acctgcggct 15480 cggagcaggt ctactggtcg ttgccagaca tgatgcaaga ccccgtgacc ttccgctcca 15540

cgcgccagat cagcaacttt ccggtggtgg gcgccgagct gttgcccgtg cactccaaga 15600

gcttctacaa cgaccaggcc gtctactccc aactcatccg ccagtttacc tctctgaccc 15660

acgtgttcaa tcgctttccc gagaaccaga ttttggcgcg cccgccagcc cccaccatca 15720

ccaccgtcag tgaaaacgtt cctgctctca cagatcacgg gacgctaccg ctgcgcaaca 15780 gcatcggagg agtccagcga gtgaccatta ctgacgccag acgccgcacc tgcccctacg 15840

tttacaaggc cctgggcata gtctcgccgc gcgtcctatc gagccgcact ttttgagcaa 15900

gcatgtccat ccttatatcg cccagcaata acacaggctg gggcctgcgc ttcccaagca 15960 agatgtttgg cggggccaag aagcgctccg accaacaccc agtgcgcgtg cgcgggcact 16020

accgcgcgcc ctggggcgcg cacaaacgcg gccgcactgg gcgcaccacc gtcgatgacg 16080 ccatcgacgc ggtggtggag gaggcgcgca actacacgcc cacgccgcca ccagtgtcca 16140 cagtggacgc ggccattcag accgtggtgc gcggagcccg gcgctatgct aaaatgaaga 16200

gacggcggag gcgcgtagca cgtcgccacc gccgccgacc cggcactgcc gcccaacgcg 16260 cggcggcggc cctgcttaac cgcgcacgtc gcaccggccg acgggcggcc atgcgggccg 16320 ctcgaaggct ggccgcgggt attgtcactg tgccccccag gtccaggcga cgagcggccg 16380

ccgcagcagc cgcggccatt agtgctatga ctcagggtcg caggggcaac gtgtattggg 16440 tgcgcgactc ggttagcggc ctgcgcgtgc ccgtgcgcac ccgccccccg cgcaactaga 16500

ttgcaagaaa aaactactta gactcgtact gttgtatgta tccagcggcg gcggcgcgca 16560 acgaagctat gtccaagcgc aaaatcaaag aagagatgct ccaggtcatc gcgccggaga 16620 tctatggccc cccgaagaag gaagagcagg attacaagcc ccgaaagcta aagcgggtca 16680

aaaagaaaaa gaaagatgat gatgatgaac ttgacgacga ggtggaactg ctgcacgcta 16740 Page 227

Sequence_Listing.txt ccgcgcccag gcgacgggta cagtggaaag gtcgacgcgt aaaacgtgtt ttgcgacccg 16800

gcaccaccgt agtctttacg cccggtgagc gctccacccg cacctacaag cgcgtgtatg 16860 atgaggtgta cggcgacgag gacctgcttg agcaggccaa cgagcgcctc ggggagtttg 16920

cctacggaaa gcggcataag gacatgctgg cgttgccgct ggacgagggc aacccaacac 16980 ctagcctaaa gcccgtaaca ctgcagcagg tgctgcccgc gcttgcaccg tccgaagaaa 17040 agcgcggcct aaagcgcgag tctggtgact tggcacccac cgtgcagctg atggtaccca 17100

agcgccagcg actggaagat gtcttggaaa aaatgaccgt ggaacctggg ctggagcccg 17160 aggtccgcgt gcggccaatc aagcaggtgg cgccgggact gggcgtgcag accgtggacg 17220 ttcagatacc cactaccagt agcaccagta ttgccaccgc cacagagggc atggagacac 17280

aaacgtcccc ggttgcctca gcggtggcgg atgccgcggt gcaggcggtc gctgcggccg 17340 cgtccaagac ctctacggag gtgcaaacgg acccgtggat gtttcgcgtt tcagcccccc 17400 ggcgcccgcg cggttcgagg aagtacggcg ccgccagcgc gctactgccc gaatatgccc 17460

tacatccttc cattgcgcct acccccggct atcgtggcta cacctaccgc cccagaagac 17520 gagcaactac ccgacgccga accaccactg gaacccgccg ccgccgtcgc cgtcgccagc 17580

ccgtgctggc cccgatttcc gtgcgcaggg tggctcgcga aggaggcagg accctggtgc 17640

tgccaacagc gcgctaccac cccagcatcg tttaaaagcc ggtctttgtg gttcttgcag 17700

atatggccct cacctgccgc ctccgtttcc cggtgccggg attccgagga agaatgcacc 17760

gtaggagggg catggccggc cacggcctga cgggcggcat gcgtcgtgcg caccaccggc 17820 ggcggcgcgc gtcgcaccgt cgcatgcgcg gcggtatcct gcccctcctt attccactga 17880

tcgccgcggc gattggcgcc gtgcccggaa ttgcatccgt ggccttgcag gcgcagagac 17940

actgattaaa aacaagttgc atgtggaaaa atcaaaataa aaagtctgga ctctcacgct 18000 cgcttggtcc tgtaactatt ttgtagaatg gaagacatca actttgcgtc tctggccccg 18060

cgacacggct cgcgcccgtt catgggaaac tggcaagata tcggcaccag caatatgagc 18120 ggtggcgcct tcagctgggg ctcgctgtgg agcggcatta aaaatttcgg ttccaccgtt 18180 aagaactatg gcagcaaggc ctggaacagc agcacaggcc agatgctgag ggataagttg 18240

aaagagcaaa atttccaaca aaaggtggta gatggcctgg cctctggcat tagcggggtg 18300 gtggacctgg ccaaccaggc agtgcaaaat aagattaaca gtaagcttga tccccgccct 18360 cccgtagagg agcctccacc ggccgtggag acagtgtctc cagaggggcg tggcgaaaag 18420

cgtccgcgcc ccgacaggga agaaactctg gtgacgcaaa tagacgagcc tccctcgtac 18480 gaggaggcac taaagcaagg cctgcccacc acccgtccca tcgcgcccat ggctaccgga 18540

gtgctgggcc agcacacacc cgtaacgctg gacctgcctc cccccgccga cacccagcag 18600 aaacctgtgc tgccaggccc gaccgccgtt gttgtaaccc gtcctagccg cgcgtccctg 18660 cgccgcgccg ccagcggtcc gcgatcgttg cggcccgtag ccagtggcaa ctggcaaagc 18720

acactgaaca gcatcgtggg tctgggggtg caatccctga agcgccgacg atgcttctga 18780 Page 228

Sequence_Listing.txt atagctaacg tgtcgtatgt gtgtcatgta tgcgtccatg tcgccgccag aggagctgct 18840

gagccgccgc gcgcccgctt tccaagatgg ctaccccttc gatgatgccg cagtggtctt 18900 acatgcacat ctcgggccag gacgcctcgg agtacctgag ccccgggctg gtgcagtttg 18960

cccgcgccac cgagacgtac ttcagcctga ataacaagtt tagaaacccc acggtggcgc 19020 ctacgcacga cgtgaccaca gaccggtccc agcgtttgac gctgcggttc atccctgtgg 19080 accgtgagga tactgcgtac tcgtacaagg cgcggttcac cctagctgtg ggtgataacc 19140

gtgtgctgga catggcttcc acgtactttg acatccgcgg cgtgctggac aggggcccta 19200 cttttaagcc ctactctggc actgcctaca acgccctggc tcccaagggt gccccaaatc 19260 cttgcgaatg ggatgaagct gctactgctc ttgaaataaa cctagaagaa gaggacgatg 19320

acaacgaaga cgaagtagac gagcaagctg agcagcaaaa aactcacgta tttgggcagg 19380 cgccttattc tggtataaat attacaaagg agggtattca aataggtgtc gaaggtcaaa 19440 cacctaaata tgccgataaa acatttcaac ctgaacctca aataggagaa tctcagtggt 19500

acgaaactga aattaatcat gcagctggga gagtccttaa aaagactacc ccaatgaaac 19560 catgttacgg ttcatatgca aaacccacaa atgaaaatgg agggcaaggc attcttgtaa 19620

agcaacaaaa tggaaagcta gaaagtcaag tggaaatgca atttttctca actactgagg 19680

cgaccgcagg caatggtgat aacttgactc ctaaagtggt attgtacagt gaagatgtag 19740

atatagaaac cccagacact catatttctt acatgcccac tattaaggaa ggtaactcac 19800

gagaactaat gggccaacaa tctatgccca acaggcctaa ttacattgct tttagggaca 19860 attttattgg tctaatgtat tacaacagca cgggtaatat gggtgttctg gcgggccaag 19920

catcgcagtt gaatgctgtt gtagatttgc aagacagaaa cacagagctt tcataccagc 19980

ttttgcttga ttccattggt gatagaacca ggtacttttc tatgtggaat caggctgttg 20040 acagctatga tccagatgtt agaattattg aaaatcatgg aactgaagat gaacttccaa 20100

attactgctt tccactggga ggtgtgatta atacagagac tcttaccaag gtaaaaccta 20160 aaacaggtca ggaaaatgga tgggaaaaag atgctacaga attttcagat aaaaatgaaa 20220 taagagttgg aaataatttt gccatggaaa tcaatctaaa tgccaacctg tggagaaatt 20280

tcctgtactc caacatagcg ctgtatttgc ccgacaagct aaagtacagt ccttccaacg 20340 taaaaatttc tgataaccca aacacctacg actacatgaa caagcgagtg gtggctcccg 20400 ggttagtgga ctgctacatt aaccttggag cacgctggtc ccttgactat atggacaacg 20460

tcaacccatt taaccaccac cgcaatgctg gcctgcgcta ccgctcaatg ttgctgggca 20520 atggtcgcta tgtgcccttc cacatccagg tgcctcagaa gttctttgcc attaaaaacc 20580

tccttctcct gccgggctca tacacctacg agtggaactt caggaaggat gttaacatgg 20640 ttctgcagag ctccctagga aatgacctaa gggttgacgg agccagcatt aagtttgata 20700 gcatttgcct ttacgccacc ttcttcccca tggcccacaa caccgcctcc acgcttgagg 20760

ccatgcttag aaacgacacc aacgaccagt cctttaacga ctatctctcc gccgccaaca 20820 Page 229

Sequence_Listing.txt tgctctaccc tatacccgcc aacgctacca acgtgcccat atccatcccc tcccgcaact 20880

gggcggcttt ccgcggctgg gccttcacgc gccttaagac taaggaaacc ccatcactgg 20940 gctcgggcta cgacccttat tacacctact ctggctctat accctaccta gatggaacct 21000

tttacctcaa ccacaccttt aagaaggtgg ccattacctt tgactcttct gtcagctggc 21060 ctggcaatga ccgcctgctt acccccaacg agtttgaaat taagcgctca gttgacgggg 21120 agggttacaa cgttgcccag tgtaacatga ccaaagactg gttcctggta caaatgctag 21180

ctaactacaa cattggctac cagggcttct atatcccaga gagctacaag gaccgcatgt 21240 actccttctt tagaaacttc cagcccatga gccgtcaggt ggtggatgat actaaataca 21300 aggactacca acaggtgggc atcctacacc aacacaacaa ctctggattt gttggctacc 21360

ttgcccccac catgcgcgaa ggacaggcct accctgctaa cttcccctat ccgcttatag 21420 gcaagaccgc agttgacagc attacccaga aaaagtttct ttgcgatcgc accctttggc 21480 gcatcccatt ctccagtaac tttatgtcca tgggcgcact cacagacctg ggccaaaacc 21540

ttctctacgc caactccgcc cacgcgctag acatgacttt tgaggtggat cccatggacg 21600 agcccaccct tctttatgtt ttgtttgaag tctttgacgt ggtccgtgtg caccggccgc 21660

accgcggcgt catcgaaacc gtgtacctgc gcacgccctt ctcggccggc aacgccacaa 21720

cataaagaag caagcaacat caacaacagc tgccgccatg ggctccagtg agcaggaact 21780

gaaagccatt gtcaaagatc ttggttgtgg gccatatttt ttgggcacct atgacaagcg 21840

ctttccaggc tttgtttctc cacacaagct cgcctgcgcc atagtcaata cggccggtcg 21900 cgagactggg ggcgtacact ggatggcctt tgcctggaac ccgcactcaa aaacatgcta 21960

cctctttgag ccctttggct tttctgacca gcgactcaag caggtttacc agtttgagta 22020

cgagtcactc ctgcgccgta gcgccattgc ttcttccccc gaccgctgta taacgctgga 22080 aaagtccacc caaagcgtac aggggcccaa ctcggccgcc tgtggactat tctgctgcat 22140

gtttctccac gcctttgcca actggcccca aactcccatg gatcacaacc ccaccatgaa 22200 ccttattacc ggggtaccca actccatgct caacagtccc caggtacagc ccaccctgcg 22260 tcgcaaccag gaacagctct acagcttcct ggagcgccac tcgccctact tccgcagcca 22320

cagtgcgcag attaggagcg ccacttcttt ttgtcacttg aaaaacatgt aaaaataatg 22380 tactagagac actttcaata aaggcaaatg cttttatttg tacactctcg ggtgattatt 22440 tacccccacc cttgccgtct gcgccgttta aaaatcaaag gggttctgcc gcgcatcgct 22500

atgcgccact ggcagggaca cgttgcgata ctggtgttta gtgctccact taaactcagg 22560 cacaaccatc cgcggcagct cggtgaagtt ttcactccac aggctgcgca ccatcaccaa 22620

cgcgtttagc aggtcgggcg ccgatatctt gaagtcgcag ttggggcctc cgccctgcgc 22680 gcgcgagttg cgatacacag ggttgcagca ctggaacact atcagcgccg ggtggtgcac 22740 gctggccagc acgctcttgt cggagatcag atccgcgtcc aggtcctccg cgttgctcag 22800

ggcgaacgga gtcaactttg gtagctgcct tcccaaaaag ggcgcgtgcc caggctttga 22860 Page 230

Sequence_Listing.txt gttgcactcg caccgtagtg gcatcaaaag gtgaccgtgc ccggtctggg cgttaggata 22920

cagcgcctgc ataaaagcct tgatctgctt aaaagccacc tgagcctttg cgccttcaga 22980 gaagaacatg ccgcaagact tgccggaaaa ctgattggcc ggacaggccg cgtcgtgcac 23040

gcagcacctt gcgtcggtgt tggagatctg caccacattt cggccccacc ggttcttcac 23100 gatcttggcc ttgctagact gctccttcag cgcgcgctgc ccgttttcgc tcgtcacatc 23160 catttcaatc acgtgctcct tatttatcat aatgcttccg tgtagacact taagctcgcc 23220

ttcgatctca gcgcagcggt gcagccacaa cgcgcagccc gtgggctcgt gatgcttgta 23280 ggtcacctct gcaaacgact gcaggtacgc ctgcaggaat cgccccatca tcgtcacaaa 23340 ggtcttgttg ctggtgaagg tcagctgcaa cccgcggtgc tcctcgttca gccaggtctt 23400

gcatacggcc gccagagctt ccacttggtc aggcagtagt ttgaagttcg cctttagatc 23460 gttatccacg tggtacttgt ccatcagcgc gcgcgcagcc tccatgccct tctcccacgc 23520 agacacgatc ggcacactca gcgggttcat caccgtaatt tcactttccg cttcgctggg 23580

ctcttcctct tcctcttgcg tccgcatacc acgcgccact gggtcgtctt cattcagccg 23640 ccgcactgtg cgcttacctc ctttgccatg cttgattagc accggtgggt tgctgaaacc 23700

caccatttgt agcgccacat cttctctttc ttcctcgctg tccacgatta cctctggtga 23760

tggcgggcgc tcgggcttgg gagaagggcg cttctttttc ttcttgggcg caatggccaa 23820

atccgccgcc gaggtcgatg gccgcgggct gggtgtgcgc ggcaccagcg cgtcttgtga 23880

tgagtcttcc tcgtcctcgg actcgatacg ccgcctcatc cgcttttttg ggggcgcccg 23940 gggaggcggc ggcgacgggg acggggacga cacgtcctcc atggttgggg gacgtcgcgc 24000

cgcaccgcgt ccgcgctcgg gggtggtttc gcgctgctcc tcttcccgac tggccatttc 24060

cttctcctat aggcagaaaa agatcatgga gtcagtcgag aagaaggaca gcctaaccgc 24120 cccctctgag ttcgccacca ccgcctccac cgatgccgcc aacgcgccta ccaccttccc 24180

cgtcgaggca cccccgcttg aggaggagga agtgattatc gagcaggacc caggttttgt 24240 aagcgaagac gacgaggacc gctcagtacc aacagaggat aaaaagcaag accaggacaa 24300 cgcagaggca aacgaggaac aagtcgggcg gggggacgaa aggcatggcg actacctaga 24360

tgtgggagac gacgtgctgt tgaagcatct gcagcgccag tgcgccatta tctgcgacgc 24420 gttgcaagag cgcagcgatg tgcccctcgc catagcggat gtcagccttg cctacgaacg 24480 ccacctattc tcaccgcgcg taccccccaa acgccaagaa aacggcacat gcgagcccaa 24540

cccgcgcctc aacttctacc ccgtatttgc cgtgccagag gtgcttgcca cctatcacat 24600 ctttttccaa aactgcaaga tacccctatc ctgccgtgcc aaccgcagcc gagcggacaa 24660

gcagctggcc ttgcggcagg gcgctgtcat acctgatatc gcctcgctca acgaagtgcc 24720 aaaaatcttt gagggtcttg gacgcgacga gaagcgcgcg gcaaacgctc tgcaacagga 24780 aaacagcgaa aatgaaagtc actctggagt gttggtggaa ctcgagggtg acaacgcgcg 24840

cctagccgta ctaaaacgca gcatcgaggt cacccacttt gcctacccgg cacttaacct 24900 Page 231

Sequence_Listing.txt accccccaag gtcatgagca cagtcatgag tgagctgatc gtgcgccgtg cgcagcccct 24960

ggagagggat gcaaatttgc aagaacaaac agaggagggc ctacccgcag ttggcgacga 25020 gcagctagcg cgctggcttc aaacgcgcga gcctgccgac ttggaggagc gacgcaaact 25080

aatgatggcc gcagtgctcg ttaccgtgga gcttgagtgc atgcagcggt tctttgctga 25140 cccggagatg cagcgcaagc tagaggaaac attgcactac acctttcgac agggctacgt 25200 acgccaggcc tgcaagatct ccaacgtgga gctctgcaac ctggtctcct accttggaat 25260

tttgcacgaa aaccgccttg ggcaaaacgt gcttcattcc acgctcaagg gcgaggcgcg 25320 ccgcgactac gtccgcgact gcgtttactt atttctatgc tacacctggc agacggccat 25380 gggcgtttgg cagcagtgct tggaggagtg caacctcaag gagctgcaga aactgctaaa 25440

gcaaaacttg aaggacctat ggacggcctt caacgagcgc tccgtggccg cgcacctggc 25500 ggacatcatt ttccccgaac gcctgcttaa aaccctgcaa cagggtctgc cagacttcac 25560 cagtcaaagc atgttgcaga actttaggaa ctttatccta gagcgctcag gaatcttgcc 25620

cgccacctgc tgtgcacttc ctagcgactt tgtgcccatt aagtaccgcg aatgccctcc 25680 gccgctttgg ggccactgct accttctgca gctagccaac taccttgcct accactctga 25740

cataatggaa gacgtgagcg gtgacggtct actggagtgt cactgtcgct gcaacctatg 25800

caccccgcac cgctccctgg tttgcaattc gcagctgctt aacgaaagtc aaattatcgg 25860

tacctttgag ctgcagggtc cctcgcctga cgaaaagtcc gcggctccgg ggttgaaact 25920

cactccgggg ctgtggacgt cggcttacct tcgcaaattt gtacctgagg actaccacgc 25980 ccacgagatt aggttctacg aagaccaatc ccgcccgcca aatgcggagc ttaccgcctg 26040

cgtcattacc cagggccaca ttcttggcca attgcaagcc atcaacaaag cccgccaaga 26100

gtttctgcta cgaaagggac ggggggttta cttggacccc cagtccggcg aggagctcaa 26160 cccaatcccc ccgccgccgc agccctatca gcagcagccg cgggcccttg cttcccagga 26220

tggcacccaa aaagaagctg cagctgccgc cgccacccac ggacgaggag gaatactggg 26280 acagtcaggc agaggaggtt ttggacgagg aggaggagga catgatggaa gactgggaga 26340 gcctagacga ggaagcttcc gaggtcgaag aggtgtcaga cgaaacaccg tcaccctcgg 26400

tcgcattccc ctcgccggcg ccccagaaat cggcaaccgg ttccagcatg gctacaacct 26460 ccgctcctca ggcgccgccg gcactgcccg ttcgccgacc caaccgtaga tgggacacca 26520 ctggaaccag ggccggtaag tccaagcagc cgccgccgtt agcccaagag caacaacagc 26580

gccaaggcta ccgctcatgg cgcgggcaca agaacgccat agttgcttgc ttgcaagact 26640 gtgggggcaa catctccttc gcccgccgct ttcttctcta ccatcacggc gtggccttcc 26700

cccgtaacat cctgcattac taccgtcatc tctacagccc atactgcacc ggcggcagcg 26760 gcagcggcag caacagcagc ggccacacag aagcaaaggc gaccggatag caagactctg 26820 acaaagccca agaaatccac agcggcggca gcagcaggag gaggagcgct gcgtctggcg 26880

cccaacgaac ccgtatcgac ccgcgagctt agaaacagga tttttcccac tctgtatgct 26940 Page 232

Sequence_Listing.txt atatttcaac agagcagggg ccaagaacaa gagctgaaaa taaaaaacag gtctctgcga 27000

tccctcaccc gcagctgcct gtatcacaaa agcgaagatc agcttcggcg cacgctggaa 27060 gacgcggagg ctctcttcag taaatactgc gcgctgactc ttaaggacta gtttcgcgcc 27120

ctttctcaaa tttaagcgcg aaaactacgt catctccagc ggccacaccc ggcgccagca 27180 cctgtcgtca gcgccatttc aactttgtat acaaaagttg tgatgagcaa ggaaattccc 27240 acgccctaca tgtggagtta ccagccacaa atgggacttg cggctggagc tgcccaagac 27300

tactcaaccc gaataaacta catgagcgcg ggaccccaca tgatatcccg ggtcaacgga 27360 atacgcgccc accgaaaccg aattctcctg gaacaggcgg ctattaccac cacacctcgt 27420 aataacctta atccccgtag ttggcccgct gccctggtgt accaggaaag tcccgctccc 27480

accactgtgg tacttcccag agacgcccag gccgaagttc agatgactaa ctcaggggcg 27540 cagcttgcgg gcggctttcg tcacagggtg cggtcgcccg ggcagggtat aactcacctg 27600 acaatcagag ggcgaggtat tcagctcaac gacgagtcgg tgagctcctc gcttggtctc 27660

cgtccggacg ggacatttca gatcggcggc gccggccgct cttcattcac gcctcgtcag 27720 gcaatcctaa ctctgcagac ctcgtcctct gagccgcgct ctggaggcat tggaactctg 27780

caatttattg aggagtttgt gccatcggtc tactttaacc ccttctcggg acctcccggc 27840

cactatccgg atcaatttat tcctaacttt gacgcggtaa aggactcggc ggacggctac 27900

gactgaatgt taagtggaga ggcagagcaa ctgcgcctga aacacctggt ccactgtcgc 27960

cgccacaagt gctttgcccg cgactccggt gagttttgct actttgaatt gcccgaggat 28020 catatcgagg gcccggcgca cggcgtccgg cttaccgccc agggagagct tgcccgtagc 28080

ctgattcggg agtttaccca gcgccccctg ctagttgagc gggacagggg accctgtgtt 28140

ctcactgtga tttgcaactg tcctaaccct ggattacatc aagatctttg ttgccatctc 28200 tgtgctgagt ataataaata cagaaattaa aatatactgg ggctcctatc gccatcctgt 28260

aaacgccacc gtcttcaccc gcccaagcaa accaaggcga accttacctg gtacttttaa 28320 catctctccc tctgtgattt acaacagttt caacccagac ggagtgagtc tacgagagaa 28380 cctctccgag ctcagctact ccatcagaaa aaacaccacc ctccttacct gccgggaacg 28440

tacgagtgcg tcaccggccg ctgcaccaca cctaccgcct gaccgtaaac cagacttttt 28500 ccggacagac ctcaataact ctgtttacca gaacaggagg tgagcttaga aaacccttag 28560 ggtattaggc caaaggcgca gctactgtgg ggtttatgaa caattcaagc aactctacgg 28620

gctattctaa ttcaggtttc tctagaatcg gggttggggt tattctctgt cttgtgattc 28680 tctttattct tatactaacg cttctctgcc taaggctcgc cgcctgctgt gtgcacattt 28740

gcatttattg tcagcttttt aaacgctggg gtcgccaccc aagatgatta ggtacataat 28800 cctaggttta ctcacccttg cgtcagccca cggtaccacc caaaaggtgg attttaagga 28860 gccagcctgt aatgttacat tcgcagctga agctaatgag tgcaccactc ttataaaatg 28920

caccacagaa catgaaaagc tgcttattcg ccacaaaaac aaaattggca agtatgctgt 28980 Page 233

Sequence_Listing.txt ttatgctatt tggcagccag gtgacactac agagtataat gttacagttt tccagggtaa 29040

aagtcataaa acttttatgt atacttttcc attttatgaa atgtgcgaca ttaccatgta 29100 catgagcaaa cagtataagt tgtggccccc acaaaattgt gtggaaaaca ctggcacttt 29160

ctgctgcact gctatgctaa ttacagtgct cgctttggtc tgtaccctac tctatattaa 29220 atacaaaagc agacgcagct ttattgagga aaagaaaatg ccttaattta ctaagttaca 29280 aagctaatgt caccactaac tgctttactc gctgcttgca aaacaaattc aaaaagttag 29340

cattataatt agaataggat ttaaaccccc cggtcatttc ctgctcaata ccattcccct 29400 gaacaattga ctctatgtgg gatatgctcc agcgctacaa ccttgaagtc aggcttcctg 29460 gatgtcagca tctgactttg gccagcacct gtcccgcgga tttgttccag tccaactaca 29520

gcgacccacc ctaacagaga tgaccaacac aaccaacgcg gccgccgcta ccggacttac 29580 atctaccaca aatacacccc aagtttctgc ctttgtcaat aactgggata acttgggcat 29640 gtggtggttc tccatagcgc ttatgtttgt atgccttatt attatgtggc tcatctgctg 29700

cctaaagcgc aaacgcgccc gaccacccat ctatagtccc atcattgtgc tacacccaaa 29760 caatgatgga atccatagat tggacggact gaaacacatg ttcttttctc ttacagtatg 29820

attaaatgag acatgattcc tcgagttttt atattactga cccttgttgc gcttttttgt 29880

gcgtgctcca cattggctgc ggtttctcac atcgaagtag actgcattcc agccttcaca 29940

gtctatttgc tttacggatt tgtcaccctc acgctcatct gcagcctcat cactgtggtc 30000

atcgccttta tccagtgcat tgactgggtc tgtgtgcgct ttgcatatct cagacaccat 30060 ccccagtaca gggacaggac tatagctgag cttcttagaa ttctttaatt atgaaattta 30120

ctgtgacttt tctgctgatt atttgcaccc tatctgcgtt ttgttccccg acctccaagc 30180

ctcaaagaca tatatcatgc agattcactc gtatatggaa tattccaagt tgctacaatg 30240 aaaaaagcga tctttccgaa gcctggttat atgcaatcat ctctgttatg gtgttctgca 30300

gtaccatctt agccctagct atatatccct accttgacat tggctggaac gcaatagatg 30360 ccatgaacca cccaactttc cccgcgcccg ctatgcttcc actgcaacaa gttgttgccg 30420 gcggctttgt cccagccaat cagcctcgcc caccttctcc cacccccact gaaatcagct 30480

actttaatct aacaggagga gatgactgac accctagatc tagaaatgga cggaattatt 30540 acagagcagc gcctgctaga aagacgcagg gcagcggccg agcaacagcg catgaatcaa 30600 gagctccaag acatggttaa cttgcaccag tgcaaaaggg gtatcttttg tctggtaaag 30660

caggccaaag tcacctacga cagtaatacc accggacacc gccttagcta caagttgcca 30720 accaagcgtc agaaattggt ggtcatggtg ggagaaaagc ccattaccat aactcagcac 30780

tcggtagaaa ccgaaggctg cattcactca ccttgtcaag gacctgagga tctctgcacc 30840 cttattaaga ccctgtgcgg tctcaaagat cttattccct ttaactaata aaaaaaaata 30900 ataaagcatc acttacttaa aatcagttag caaatttctg tccagtttat tcagcagcac 30960

ctccttgccc tcctcccagc tctggtattg cagcttcctc ctggctgcaa actttctcca 31020 Page 234

Sequence_Listing.txt caatctaaat ggaatgtcag tttcctcctg ttcctgtcca tccgcaccca ctatcttcat 31080

gttgttgcag atgaagcgcg caagaccgtc tgaagatacc ttcaaccccg tgtatccata 31140 tgacacggaa accggtcctc caactgtgcc ttttcttact cctccctttg tatcccccaa 31200

tgggtttcaa gagagtcccc ctggggtact ctctttgcgc ctatccgaac ctctagttac 31260 ctccaatggc atgcttgcgc tcaaaatggg caacggcctc tctctggacg aggccggcaa 31320 ccttacctcc caaaatgtaa ccactgtgag cccacctctc aaaaaaacca agtcaaacat 31380

aaacctggaa atatctgcac ccctcacagt tacctcagaa gccctaactg tggctgccgc 31440 cgcacctcta atggtcgcgg gcaacacact caccatgcaa tcacaggccc cgctaaccgt 31500 gcacgactcc aaacttagca ttgccaccca aggacccctc acagtgtcag aaggaaagct 31560

agccctgcaa acatcaggcc ccctcaccac caccgatagc agtaccctta ctatcactgc 31620 ctcaccccct ctaactactg ccactggtag cttgggcatt gacttgaaag agcccattta 31680 tacacaaaat ggaaaactag gactaaagta cggggctcct ttgcatgtaa cagacgacct 31740

aaacactttg accgtagcaa ctggtccagg tgtgactatt aataatactt ccttgcaaac 31800 taaagttact ggagccttgg gttttgattc acaaggcaat atgcaactta atgtagcagg 31860

aggactaagg attgattctc aaaacagacg ccttatactt gatgttagtt atccgtttga 31920

tgctcaaaac caactaaatc taagactagg acagggccct ctttttataa actcagccca 31980

caacttggat attaactaca acaaaggcct ttacttgttt acagcttcaa acaattccaa 32040

aaagcttgag gttaacctaa gcactgccaa ggggttgatg tttgacgcta cagccatagc 32100 cattaatgca ggagatgggc ttgaatttgg ttcacctaat gcaccaaaca caaatcccct 32160

caaaacaaaa attggccatg gcctagaatt tgattcaaac aaggctatgg ttcctaaact 32220

aggaactggc cttagttttg acagcacagg tgccattaca gtaggaaaca aaaataatga 32280 taagctaact ttgtggacca caccagctcc atctcctaac tgtagactaa atgcagagaa 32340

agatgctaaa ctcactttgg tcttaacaaa atgtggcagt caaatacttg ctacagtttc 32400 agttttggct gttaaaggca gtttggctcc aatatctgga acagttcaaa gtgctcatct 32460 tattataaga tttgacgaaa atggagtgct actaaacaat tccttcctgg acccagaata 32520

ttggaacttt agaaatggag atcttactga aggcacagcc tatacaaacg ctgttggatt 32580 tatgcctaac ctatcagctt atccaaaatc tcacggtaaa actgccaaaa gtaacattgt 32640 cagtcaagtt tacttaaacg gagacaaaac taaacctgta acactaacca ttacactaaa 32700

cggtacacag gaaacaggag acacaactcc aagtgcatac tctatgtcat tttcatggga 32760 ctggtctggc cacaactaca ttaatgaaat atttgccaca tcctcttaca ctttttcata 32820

cattgcccaa gaaggaagcg gagctactaa cttcagcctg ctgaagcagg ctggtgacgt 32880 cgaggagaat cctggcccaa tggtgagcaa aggcgaagag ctgttcaccg gcgtggtgcc 32940 catcctggtg gagctggacg gcgacgtgaa cggccacaag ttcagcgtga gcggcgaggg 33000

cgagggcgac gccacctacg gcaagctgac cctgaagctg ctgtgcacca ccggcaagct 33060 Page 235

Sequence_Listing.txt gcccgtgccc tggcccaccc tggtgaccac cctgggctac ggcgtgcagt gcttcgcccg 33120

gtaccccgac cacatgaagc agcacgactt cttcaagagc gccatgcccg agggctacgt 33180 gcaggagcgg accatcttct tcaaggacga cggcaactac aagacccggg ccgaggtgaa 33240

gttcgagggc gacaccctgg tgaaccggat cgagctgaag ggcatcgact tcaaggagga 33300 cggcaacatc ctgggccaca agctggagta caactacaac agccacaacg tgtacatcac 33360 cgccgacaag cagaagaacg gcatcaaggc caacttcaag atccggcaca acatcgagga 33420

cggcggcgtg cagctggccg accactacca gcagaacacc cccatcggcg acggccccgt 33480 gctgctgccc gacaaccact acctgagcta ccagagcgcc ctgttcaagg accccaacga 33540 gaagcgggac cacatggtgc tgctggagtt cctgaccgcc gccggcatca ccgagggcat 33600

gaacgagctc tataagtaat aaagaatcgt ttgtgttatg tttcaacgtg tttatttttc 33660 aattgcagaa aatttcgaat catttttcat tcagtagtat agccccacca ccacatagct 33720 tatacagatc accgtacctc aactttgtat aataaagttg taatcaaact cacagaaccc 33780

tagtattcaa cctgccacct ccctcccaac acacagagta cacagtcctt tctccccggc 33840 tggccttaaa aagcatcata tcatgggtaa cagacatatt cttaggtgtt atattccaca 33900

cggtttcctg tcgagccaaa cgctcatcag tgatattaat aaactccccg ggcagctcac 33960

ttaagttcat gtcgctgtcc agctgctgag ccacaggctg ctgtccaact tgcggttgct 34020

taacgggcgg cgaaggagaa gtccacgcct acatgggggt agagtcataa tcgtgcatca 34080

ggatagggcg gtggtgctgc agcagcgcgc gaataaactg ctgccgccgc cgctccgtcc 34140 tgcaggaata caacatggca gtggtctcct cagcgatgat tcgcaccgcc cgcagcataa 34200

ggcgccttgt cctccgggca cagcagcgca ccctgatctc acttaaatca gcacagtaac 34260

tgcagcacag caccacaata ttgttcaaaa tcccacagtg caaggcgctg tatccaaagc 34320 tcatggcggg gaccacagaa cccacgtggc catcatacca caagcgcagg tagattaagt 34380

ggcgacccct cataaacacg ctggacataa acattacctc ttttggcatg ttgtaattca 34440 ccacctcccg gtaccatata aacctctgat taaacatggc gccatccacc accatcctaa 34500 accagctggc caaaacctgc ccgccggcta tacactgcag ggaaccggga ctggaacaat 34560

gacagtggag agcccaggac tcgtaaccat ggatcatcat gctcgtcatg atatcaatgt 34620 tggcacaaca caggcacacg tgcatacact tcctcaggat tacaagctcc tcccgcgtta 34680 gaaccatatc ccagggaaca acccattcct gaatcagcgt aaatcccaca ctgcagggaa 34740

gacctcgcac gtaactcacg ttgtgcattg tcaaagtgtt acattcgggc agcagcggat 34800 gatcctccag tatggtagcg cgggtttctg tctcaaaagg aggtagacga tccctactgt 34860

acggagtgcg ccgagacaac cgagatcgtg ttggtcgtag tgtcatgcca aatggaacgc 34920 cggacgtagt catatttcct gaagcaaaac caggtgcggg cgtgacaaac agatctgcgt 34980 ctccggtctc gccgcttaga tcgctctgtg tagtagttgt agtatatcca ctctctcaaa 35040

gcatccaggc gccccctggc ttcgggttct atgtaaactc cttcatgcgc cgctgccctg 35100 Page 236

Sequence_Listing.txt ataacatcca ccaccgcaga ataagccaca cccagccaac ctacacattc gttctgcgag 35160

tcacacacgg gaggagcggg aagagctgga agaaccatgt tttttttttt attccaaaag 35220 attatccaaa acctcaaaat gaagatctat taagtgaacg cgctcccctc cggtggcgtg 35280

gtcaaactct acagccaaag aacagataat ggcatttgta agatgttgca caatggcttc 35340 caaaaggcaa acggccctca cgtccaagtg gacgtaaagg ctaaaccctt cagggtgaat 35400 ctcctctata aacattccag caccttcaac catgcccaaa taattctcat ctcgccacct 35460

tctcaatata tctctaagca aatcccgaat attaagtccg gccattgtaa aaatctgctc 35520 cagagcgccc tccaccttca gcctcaagca gcgaatcatg attgcaaaaa ttcaggttcc 35580 tcacagacct gtataagatt caaaagcgga acattaacaa aaataccgcg atcccgtagg 35640

tcccttcgca gggccagctg aacataatcg tgcaggtctg cacggaccag cgcggccact 35700 tccccgccag gaaccatgac aaaagaaccc acactgatta tgacacgcat actcggagct 35760 atgctaacca gcgtagcccc gatgtaagct tgttgcatgg gcggcgatat aaaatgcaag 35820

gtgctgctca aaaaatcagg caaagcctcg cgcaaaaaag aaagcacatc gtagtcatgc 35880 tcatgcagat aaaggcaggt aagctccgga accaccacag aaaaagacac catttttctc 35940

tcaaacatgt ctgcgggttt ctgcataaac acaaaataaa ataacaaaaa aacatttaaa 36000

cattagaagc ctgtcttaca acaggaaaaa caacccttat aagcataaga cggactacgg 36060

ccatgccggc gtgaccgtaa aaaaactggt caccgtgatt aaaaagcacc accgacagct 36120

cctcggtcat gtccggagtc ataatgtaag actcggtaaa cacatcaggt tgattcacat 36180 cggtcagtgc taaaaagcga ccgaaatagc ccgggggaat acatacccgc aggcgtagag 36240

acaacattac agcccccata ggaggtataa caaaattaat aggagagaaa aacacataaa 36300

cacctgaaaa accctcctgc ctaggcaaaa tagcaccctc ccgctccaga acaacataca 36360 gcgcttccac agcggcagcc ataacagtca gccttaccag taaaaaagaa aacctattaa 36420

aaaaacacca ctcgacacgg caccagctca atcagtcaca gtgtaaaaaa gggccaagtg 36480 cagagcgagt atatatagga ctaaaaaatg acgtaacggt taaagtccac aaaaaacacc 36540 cagaaaaccg cacgcgaacc tacgcccaga aacgaaagcc aaaaaaccca caacttcctc 36600

aaatcgtcac ttccgttttc ccacgttacg tcacttccca ttttaagaaa actacaattc 36660 ccaacacata caagttactc cgccctaaaa cctacgtcac ccgccccgtt cccacgcccc 36720 gcgccacgtc acaaactcca ccccctcatt atcatattgg cttcaatcca aaataaggta 36780

tattattgat gatg 36794

<210> 14 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide

Page 237

Sequence_Listing.txt <400> 14 Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn 1 5 10 15

Pro Gly Pro

<210> 15 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <400> 15

Val Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val 1 5 10 15

Glu Ser Asn Pro Gly Pro 20

<210> 16 <211> 20 <212> PRT <213> Artificial Sequence

<220> <223> Synthetic peptide

<400> 16

Gln Cys Thr Asn Tyr Ala Leu Leu Lys Leu Ala Gly Asp Val Glu Ser 1 5 10 15

Asn Pro Gly Pro 20

<210> 17 <211> 18 <212> PRT <213> Artificial Sequence

<220> <223> Synthetic peptide

<400> 17 Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro 1 5 10 15

Gly Pro

<210> 18 <211> 22 <212> PRT <213> Artificial Sequence Page 238

Sequence_Listing.txt <220> <223> Synthetic peptide <400> 18

Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val 1 5 10 15

Glu Glu Asn Pro Gly Pro 20

<210> 19 <211> 25 <212> PRT <213> Artificial Sequence

<220> <223> Synthetic peptide <400> 19 Gly Ser Gly Val Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala 1 5 10 15

Gly Asp Val Glu Ser Asn Pro Gly Pro 20 25

<210> 20 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <400> 20

Gly Ser Gly Gln Cys Thr Asn Tyr Ala Leu Leu Lys Leu Ala Gly Asp 1 5 10 15

Val Glu Ser Asn Pro Gly Pro 20

<210> 21 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide

<400> 21 Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu 1 5 10 15

Glu Asn Pro Gly Pro 20

Page 239

Sequence_Listing.txt <210> 22 <211> 35876 <212> DNA <213> Artificial Sequence <220> <223> Synthetic adenovirus genome Ad9 E3-15k-P2A-YPet <400> 22 ctatctatat aatatacccc acaaagtaaa caaaagttaa tatgcaaatg agcttttgaa 60 ttttaacggt ttcggggcgg agccaacgct gattggacga gagaagacga tgcaaatgac 120

gtcacgacgc acggctaacg gtcgccgcgg aggcgtggcc tagcccggaa gcaagtcgcg 180 gggctgatga cgtataaaaa agcggacttt agacccggaa acggccgatt ttcccgcggc 240 cacgcccgga tatgaggtaa ttctgggcgg atgcaagtga aattaggtca ttttggcgcg 300

aaaactgaat gaggaagtga aaagcgaaaa ataccggtcc ctcccagggc ggaatattta 360 ccgagggccg agagactttg accgattacg tgggggtttc gattgcggtg tttttttcgc 420 gaatttccgc gtccgtgtca aagtccggtg tttatgtcac agatcagctg atccgcaggg 480

tatttaaacc agtcgagtcc gtcaagaggc cactcttgag tgccagcgag tagagatttc 540 tctgagctcc gctcccagag accgagaaaa atgagacacc tgcgcctcct gccttcaact 600

gtgcccggtg agctggctgt gcttatgctg gaggactttg tggatacagt attggaggac 660

gaactgcatc caagtccgtt cgagctggga cccacacttc aggatctcta tgatctggag 720

gtagatgccc atgatgacga ccctaacgag gaggctgtga atttaatatt tccagaatct 780

atgattcttc aggctgacat agccaacgaa tctactccac ttcatacacc gactctgtca 840 cccatacctg aattggaaga ggaggacgaa ctagacctcc ggtgttatga ggaaggtttt 900

cctcccagcg attcagagga tgaacggggt gagcagacca tggctctgat ctcagactat 960

gcttgtgtga ttgtggagga gcaagatgtg attgaaaaat ctactgagcc agtacaaggc 1020 tgtaggaact gccagtacca ccgggataag tccggagatg tgaacgcctc ctgcgctttg 1080

tgctatatga aacagacttt cagctttatt tacagtaagt ggagtgaatg tgagagaggc 1140 tgagtgctta acacataact gtaatgcttg aacagctgtg ctaagtgtgg tttattttgt 1200 tactaggtcc ggtgtcagag gatgagttat caccctcaga agaagaccac ccgtctcccc 1260

ctgagctgtc aggcgaaacg cccctgcaag tgttcagacc caccccagtc agacccagtg 1320 gcgagaggcg agcggctgtt gacaaaattg aggacttgtt gcaggacatg ggtggggatg 1380 aacctttgga cctgagcttg aaacgcccca ggaactagac gcagctgcgc ttagtcatgt 1440

gtaaataaag ttgtacaata aaagtctatg tgacgcatgc aaggtgtggt ttatgactca 1500 tgggcggggc ttagtcctat ataagtggca acacctgggc acttgggcac agaccttcag 1560

ggagttcctg atggatgtgt ggactatcct tgcagacttt agcaagacac gccggcttgt 1620 agaggatagt tcagacgggt gctccgggtt ctggagacac tggtttggaa ctcctctatc 1680 tcgcctggtg tacacagtta agaaggatta taaagaggaa tttgaaaata tttttgctga 1740

ctgctctggc ctgctagatt ctctgaatct tggccaccag tcccttttcc aggaaagggt 1800 Page 240

Sequence_Listing.txt actccacagc cttgattttt ccagcccagg gcgcactaca gccggggttg cttttgtggt 1860

ttttctggtt gacaaatgga gccaggacac ccaactgagc aggggctaca tcctggactt 1920 cgcagccatg cacctgtgga gggcctggat caggcagcgg ggacagagaa tcttgaatta 1980

ctggcttcta cagccagcag ctccgggtct tcttcgtcta cacagacaaa catccatgtt 2040 ggaggaagaa atgaggcagg ccatggacga gaacccgagg agcggcctgg accctccgtc 2100 ggaagaggag ctggattgaa tcaggtatcc agcctgtacc cagagcttag caaggtgctg 2160

acatccatgg ccaggggagt taagagggag aggagcgatg ggggtaatac cgggatgatg 2220 accgagctga cggccagcct gatgaatcgg aagcgcccag agcgccttac ctggtacgag 2280 ctacagcagg agtgcaggga tgagttgggc ctgatgcagg ataaatatgg cctggagcag 2340

ataaaaaccc attggttgaa cccagatgag gattgggagg aggctattaa gaagtatgcc 2400 aagatagccc tgcgcccaga ttgcaagtac atagtgacca agaccgtgaa tatcagacat 2460 gcctgctaca tctcggggaa cggggcagag gtggtcatcg ataccctgga caaggccgcc 2520

ttcaggtgtt gcatgatggg aatgagagca ggagtgatga atatgaattc catgatcttc 2580 atgaacatga agttcaatgg agagaagttt aatggggtgc tgttcatggc caacagccac 2640

atgaccctgc atggctgcag tttcttcggc ttcaacaata tgtgcgcaga ggtctggggc 2700

gcttccaaga tcaggggatg taagttttat ggctgctgga tgggcgtggt cggaagaccc 2760

aagagcgaga tgtctgtgaa gcagtgtgtg tttgagaaat gctacctggg agtctctacc 2820

gagggcaatg ctagagtgag acactgctct tccctggaga cgggctgctt ctgcctggtg 2880 aagggcacag cctctctgaa gcataatatg gtgaagggct gcacggatga gcgcatgtac 2940

aacatgctga cctgcgattc gggggtctgc catatcctga agaacatcca tgtgacctcc 3000

caccccagaa agaagtggcc agtgtttgag aataacctgc tgatcaagtg ccatatgcac 3060 ctgggagcca gaaggggcac cttccagccg taccagtgca actttagcca gaccaagctg 3120

ctgttggaga acgatgcctt ctccagggtg aacctgaacg gcatctttga catggatgtc 3180 tcggtgtaca agatcctgag atacgatgag accaagtcca gggtgcgcgc ttgcgagtgc 3240 gggggcagac acaccaggat gcagccagtg gccctggatg tgaccgagga gctgagacca 3300

gaccacctgg tgatggcctg taccgggacc gagttcagct ccagtgggga ggacacagat 3360 tagaggtagg tcgagtgagt agtgggcgtg gctaaggtga ctataaaggc gggtgtctta 3420 cgagggtctt tttgcttttc tgcagacatc atgaacggga ccggcggggc cttcgaaggg 3480

gggcttttta gcccttattt gacaacccgc ctgccgggat gggccggagt tcgtcagaat 3540 gtgatgggat cgacggtgga tgggcgccca gtgcttccag caaattcctc gaccatgacc 3600

tacgcgaccg tggggagctc gtcgctcgac agcaccgccg cagccgcggc agccgcagct 3660 gccatgacag cgacgagact ggcctcgagc tacatgccca gcagcggcag cagcccctct 3720 gtgcccagtt ccatcatcgc cgaggagaaa ctgctggccc tgctggccga gctggaagcc 3780

ctgagccgcc agctggccgc cctgacccag caggtgtccg agctccgcga gcagcaacag 3840 Page 241

Sequence_Listing.txt cagcaaaata aatgaaaact tcaataaaca cagattctga ttcaaacagc aaagcatctt 3900

tattatttat tttttcgcgc gcggtaggcc ctggtccacc tctcccgatc attgagagtg 3960 cggtggattt tttccaggac ccggtagagg tgggattgga tgttgaggta catgggcatg 4020

agcccgtccc gggggtggag gtagcaccac tgcatggcct cgtgctctgg ggtcgtgttg 4080 tagatgatcc agtcatagca ggggcgctgg gcgtggtgct ggatgatgtc tttgagaagg 4140 agactgatgg ccacggggag ccccttggtg taggtattgg cgaagcggtt gagctgggag 4200

ggatgcatgc ggggggagat gatgtgcagt ttggcctgga tcttgaggtt ggcgatgttg 4260 ccacccagat cccgccgggg gttcatgttg tgcaggacca ccaggacggt gtagcccgtg 4320 cacttgggga acttgtcatg caacttggaa gggaatgcgt ggaagaattt ggagacgccc 4380

ttgtgcccgc ccaggttttc catgcattca tccatgatga tggcgatggg cccgtgggct 4440 gcggctttgg caaagacgtt tctggggtca gatacatcat aattatgctc ctgggtgaga 4500 tcatcataag acattttaat gaatttgggg cggagggtgc cagattgggg gacgatggtt 4560

ccctcgggcc ccggggcgaa gttcccctca cagatctgca tctcccaggc tttcatctcg 4620 gaggggggga tcatgtccac ctgcggggcg atgaaaaaaa cggtttccgg ggctggggtg 4680

atgagctgcg aagagagcag gtttctcaac agctgggact tgccgcaccc ggtcgggccg 4740

tagatgaccc cgatgacggg ttgcaggtgg tagttcaagg acatgcagct gccgtcgtcc 4800

cggaggaggg gggccacctc gttgagcatg tctctgactt ggaggttttc ccgaacgagc 4860

tcgccgagga ggcggtcccc gcccagcgag aggagctctt gcagggaagc aaagtttttc 4920 aggggcttga gtccgtcggc catgggcatc ttggcgaggg tctgcgagag gagctccagg 4980

cggtcccaga gctcggtgac gtgctctacg gcatctcgat ccagcagact tcctcgtttc 5040

gggggttggg acgactgcga ctgtagggca cgagacgatg ggcgtccagc gcggccagcg 5100 tcatgtcctt ccagggtctc agggtccgag tgagggtggt ctccgtcacg gtgaaggggt 5160

gggcccctgg ctgggcgctt gcaagggtgc gcttgagact catcctgctg gtgctgaaac 5220 gggcacggtc ttcgccctgc gagtcggcga gatagcagtt gaccatgagc tcgtagttga 5280 gggcctcggc ggcgtggccc ttggcgcgga gcttgccctt ggaagagcgc ccgcaggcgg 5340

gacagaggag ggattgcagg gcgtagagct tgggggcgag aaagacggac tcgggagcga 5400 aagcgtccgc tccgcagtgg gcgcagacgg tctcgcactc gacgagccag gtgagctctg 5460 gctgctcggg gtcaaaaacc agttttcccc cgttcttttt gatgcgcttc ttacctcgcg 5520

tctccatgag tctgtgtccg cgctcggtga caaacaggct gtcggtgtcc ccgtagacgg 5580 acttgattgg cctgtcctgc aggggcgtcc cgcggtcctc ctcgtagaga aactcggacc 5640

actctgagac aaaggcgcgc gtccacgcca agacaaagga ggccacgtgc gaggggtagc 5700 ggtcgttgtc cactaggggg tccacctttt ccaccgtgtg cagacacatg tccccctcct 5760 ccgcatccaa gaaggtgatt ggcttgtagg tgtaggccac gtgaccgggg gtccccgacg 5820

ggggggtata aaagggggcg ggtctgtgct cgtcctcact ctcttccgcg tcgctgtcca 5880 Page 242

Sequence_Listing.txt cgagcgccag ctgttggggt aggtattccc tctcgagagc gggcatgacc tcggcactca 5940

ggttgtcagt ttctagaaac gaggaggatt tgatgttggc ttgccctgcc gcgatgcttt 6000 ttaggagact ttcatccatc tggtcagaaa agactatttt tttattgtca agcttggtgg 6060

cgaaggagcc atagagggcg ttggatagaa gcttggcgat ggatctcatg gtctgatttt 6120 tgtcacggtc ggcgcgctcc ttggccgcga tgtttagctg gacatactcg cgcgcgacgc 6180 acttccattc ggggaagacg gtggtgcgct cgtcgggcac gatcctgacg cgccagccgc 6240

ggttatgcag ggtgaccagg tccacgctgg tggccacctc gccgcgcagg ggctcgttgg 6300 tccagcagag tctgccgccc ttgcgcgagc agaacggggg cagcacatca agcagatgct 6360 cgtcaggggg gtccgcatcg atggtgaaga tgcccggaca gagttccttg tcaaaataat 6420

cgatttttga ggatgcatca tccaaggcca tctgccactc gcgggcggcc agcgctcgct 6480 cgtaggggtt gaggggcgga ccccagggca tgggatgagt gagggcggag gcgtacatgc 6540 cgcagatgtc gtagacatag atgggctccg agaggatgcc gatgtaggtg ggataacagc 6600

gccccccgcg gatgctggcg cgcacgtagt catacaactc gtgcgagggg gccaagaagg 6660 cggggccgag attggtgcgc tggggctgct cggcgcggaa gacgatctgg cgaaagatgg 6720

cgtgcgagtt ggaggagatg gtgggccgtt ggaagatgtt aaagtgggcg tggggcaagc 6780

ggaccgagtc gcggatgaag tgcgcgtagg agtcttgcag cttggcgacg agctcggcgg 6840

tgacgaggac gtccatggcg cagtagtcca gcgtttcgcg gatgatgtca taacccgcct 6900

ctcctttctt ctcccacagc tcgcggttga gggcgtactc ctcgtcatcc ttccagtact 6960 cccggagcgg gaatcctcga tcgtccgcac ggtaagagcc cagcatgtag aaatggttca 7020

cggccttgta gggacagcag cccttctcca cggggagggc gtaagcttga gcggccttgc 7080

ggagcgaggt gtgcgtcagg gcgaaggtgt ccctgaccat gactttcaag aactggtact 7140 tgaaatccga gtcgtcgcag ccgccgtgct cccagagctc gaaatcggtg cgcttcttcg 7200

agagggggtt aggcagagcg aaagtgacgt cattgaagag aatcttgcct gctcgcggca 7260 tgaaattgcg ggtgatgcgg aaagggcccg ggacggaggc tcggttgttg atcacctggg 7320 cggcaaggac gatctcgtcg aagccgttga tgttgtgccc gacgatgtag agttccatga 7380

atcgcgggcg gcctttgatg tgcggcagct ttttgagctc ctcgtaggtg aggtcctcgg 7440 ggcattgcag gccgtgctgc tctagcgccc actcctggag atgtgggttg gcttgcatga 7500 aggaagccca gagctcgcgg gccatgaggg tctggagctc gtcgcgaaag aggcggaact 7560

gctggcccac ggccatcttt tctggggtga cgcagtagaa ggtgaggggg tcccgctccc 7620 agcgatccca gcgtaagcgc acggcgagat cgcgagcgag ggcgaccagc tcgggttccc 7680

ccgagaattt catgaccagc atgaagggga cgagctgctt gccgaaggac cccatccagg 7740 tgtaggtttc tacatcgtag gtgacaaaga gccgctccgt gcgaggatga gagccgattg 7800 ggaagaactg gatttcctgc caccagttgg acgagtggct gttgatgtga tgaaagtaga 7860

aatcccgccg gcgaaccgag cactcgtgct gatgcttgta aaagcgtccg cagtactcgc 7920 Page 243

Sequence_Listing.txt agcgctgcac gggctgtacc tcatccacga gatacacagc gcgtcccttg aggaggaact 7980

tcaggagtgg cggccctggc tggtggcttt catgttcgcc tgcgtgggac tcaccctggg 8040 gctcctcgag gacggagagg ctgacgagcc cgcgcgggag ccaggtccag atctcggcgc 8100

ggcgggggcg gagagcgaag acgagggcgc gcagttggga gctgtccatg gtgtcgcgga 8160 gatccaggtc cgggggcagg gttctgaggt tgacctcgta gaggcgggtg agggcgtgct 8220 tgagatgcag atggtacttg atctccacgg gtgagttggt ggtcgtgtcc acgcattgca 8280

tgagcccgta gctgcgcggg gccacgaccg tgccgcggtg cgcttttaga agcggtgtcg 8340 cgggcgtgct cccggcggca gcggcggttc tggccccgcg ggcaggggcg gcagaggcac 8400 gtcggcgtgg cgctcgggca ggtcccggtg ctgcgccctg agagcgctgg cgtgcgcgac 8460

gacgcggcgg ttgacatcct ggatctgccg cctctgcgtg aagaccacgg gccccgtgac 8520 tttgaacctg aaagacagtt caacagaatc aatctctgcg tcattgacgg cggcctgacg 8580 caggatctct tgcacgtcgc ccgagttgtc ctggtaggcg atctcggtca tgaactgttc 8640

gatctcctcc tcctggagat cgccgcggcc cgcgcgctcc acggtggcgg cgaggtcatt 8700 ggagatgcgg cccatgagct gcgagaaggc gcccaggccg ctctcgttcc agacgcggct 8760

gtagaccacg tccccgtcgg cgtcgcgtgc gcgcatgacc acctgcgcga ggttgagctc 8820

cacgtgccgc gtgaagacgg cgtagttgcg caggcgctgg aagaggtagt tgagggtggt 8880

ggcgatgtgc tcggtgacga agaagtacat gatccagcgg cgcaggggca tctcgctgat 8940

gtcgccgatg gcctccagcc tttccatggc ctcgtagaaa tccacggcga agttgaaaaa 9000 ctgggcattg cgggccgaga ccgtgagctc gtcttccagg agccggatga gctcggcgat 9060

ggtggcgcgc acctcgcgct cgaaatcccc gggggcctcc tcttcttcct cttcttccat 9120

gacgacctct tcttctattt cttcctctgg gggcggtggt ggtggcgggg cccgacgacg 9180 acggcgacgc accgggagac ggtcgacgaa gcgctcgatc atctccccgc ggcggcgacg 9240

catggtttcg gtgacggcgc gaccccgttc gcgaggacgc agcgtgaaga cgccgccggt 9300 catctcccgg taatggggcg ggtccccgtt gggcagcgat agggcgctga cgatgcatct 9360 tatcaattgc ggtgtagggg acgtgagcgc gtcgagatcg accggatcgg agaatctttc 9420

gaggaaagcg tctagccaat cgcagtcgca aggtaagctc aaacacgtag cagccctgtg 9480 gacgctgtta gaattgcggt tgctgatgat gtaattgaag taggcgtttt tgaggcggcg 9540 gatggtggcg aggaggacca ggtccttggg tcccgcttgc tggatgcgga gccgctcggc 9600

catgccccag gcctggccct gacaccggct caggttcttg tagtagtcat gcatgagcct 9660 ctcgatgtca tcactggcgg aggcggagtc ttccatgcgg gtgaccccga cgcccctgag 9720

cggctgcacg agcgccaggt cggcgacgac gcgctcggcg aggatggcct gttgcacgcg 9780 ggtgagggtg tcctggaagt cgtccatgtc gacaaagcgg tggtaggccc cggtgttgat 9840 ggtgtaggtg cagttggcca tgagcgacca gttgacggtc tgcaggccgg gttgcacgac 9900

ctcggagtac ctgagccgcg agaaggcgcg cgagtcgaag acgtagtcat tgcaggtgcg 9960 Page 244

Sequence_Listing.txt cacgaggtac tggtagccga ctaggaagtg cggcggcggc tggcggtaga gcggccagcg 10020

ctgggtggcc ggcgcgcccg gggccaggtc ctcgagcatg aggcggtggt agccgtagag 10080 gtagcgggac atccaggtga tgccggcggc ggtggtggag gcgcgcggga actcgcggac 10140

gcggttccag atgttgcgca gcggcaggaa atagtccatg gtcggcacgg tctggccggt 10200 gagacgcgcg cagtcattga cgctctagag gcaaaaacga aagcggttga gcgggctctt 10260 cctccgtagc ctggcggaac gcaaacgggt taggccgcgt gtgtaccccg gttcgagtcc 10320

ccttgaatca ggctggagcc gcgactaacg tggtattggc actcccgtct cgacccgagc 10380 ccgatagccg ccaggatacg gcggagagtc ctttttgccg gccaaggggg gtcgctagac 10440 ttgaaagcga ccgaaaaccc tgccgggtag tggctcgcgc ccgtagtctg gagaagcatc 10500

gccagggttg agtcgcggca gaacccggtt cgcggacggc cgcggcgagc gggacttggt 10560 caccccgccg atttaaagac ccacagccag ccgacttctc cagttacggg agcgagcccc 10620 cttttttctt tttgccagat gcatcccgtc ctgcgccaaa tgcgtcccac ccccccggcg 10680

accaccgcga ccgcggccgt agcaggcgcc ggcgctagcc agccacagcc acagacagag 10740 atggacttgg aagagggcga agggctggcg agactggggg cgccgtcccc ggagcgacac 10800

ccccgcgtgc agctgcagaa ggacgtgcgc ccggcgtacg tgcctgcgca gaacctgttc 10860

agggaccgca gcggggagga gcccgaggag atgcgcgact gccggtttcg ggcgggcagg 10920

gagctgcgcg agggcctgga ccgccagcgc gtgctgcgcg acgaggattt cgagccgaac 10980

gagcagacgg ggatcagccc cgcgcgcgct cacgtggcgg cggccaacct ggtgacggcc 11040 tacgagcaga cggtgaagca ggagcgcaac ttccaaaaga gtttcaacaa ccacgtgcgc 11100

accctgatcg cgcgcgagga ggtggccctg ggcctgatgc acctgtggga cctggcggag 11160

gccatcgtgc agaacccgga cagcaagcct ctgacggcgc agctgttcct ggtggtgcag 11220 cacagcaggg acaacgaggc gttcagggag gcactgctga acatcgccga gcccgagggt 11280

cgctggctgc tggagctgat caacatcttg cagagcatcg tagtgcagga gcgcagcctg 11340 agcttggccg agaaggtggc ggcgatcaac tactcggtgc tgagcctggg caagttttac 11400 gcgcgcaaga tttacaagac gccgtacgtg cccatagaca aggaggtgaa gatagacagc 11460

ttttacatgc gcatggcgct caaggtgctg acgctgagcg acgacctggg cgtgtaccgc 11520 aacgaccgca tccacaaggc cgtgagcacg agccggcggc gcgagctaag cgaccgcgag 11580 ctgatgctga gcctgcgccg ggcgctggta gggggcgctg ccggcggcga ggagtcctac 11640

ttcgacatgg gggcggacct gcattggcag ccgagccggc gcgccttgga ggccgcctac 11700 ggtccagagg acttggatga ggaagaggaa gaggaggagg atgcacccgc tgcggggtac 11760

tgacgcctcc gtgatgtgtt tttagatgca gcaagccccg gaccccgcca taagggcggc 11820 gctgcaaagc cagccgtccg gtctagcatc ggacgactgg gaggccgcga tgcaacgcat 11880 catggccctg acgacccgca accccgagtc ctttagacaa cagccgcagg ccaacagact 11940

ctcggccatt ctggaggcgg tggtcccctc tcggaccaac cccacgcacg agaaggtgct 12000 Page 245

Sequence_Listing.txt ggcgatcgtg aacgcgctgg cggagaacaa ggccatccgt cccgacgagg ccgggctggt 12060

gtacaacgcc ctgctggagc gcgtgggccg ctacaacagc acgaacgtgc agtccaacct 12120 ggaccggctg gtgacggacg tgcgcgaggc cgtggcgcag cgcgagcggt tcaagaacga 12180

gggcctgggc tcgctggtgg cgctgaacgc cttcctggcg acgcagccgg cgaacgtgcc 12240 gcgcgggcag gacgattaca ccaactttat cagcgcgctg cggctgatgg tgaccgaggt 12300 tccccagagc gaggtgtacc agtcgggccc ggactacttt ttccagacga gccggcaggg 12360

cttgcagacg gtgaacctga gccaggcttt caagaacctg cgagggctgt ggggcgtgca 12420 ggcgcccgtg ggcgaccggt cgacggtgag cagcttgctg acgcccaact cgcggctgct 12480 gctgctgctg atcgcgccct tcaccgacag cggcagcgtg aaccgcaact cgtacctggg 12540

ccatctgctg acgctgtacc gcgaggccat aggccaggcg caggtggacg agcagacctt 12600 ccaggagatc actagcgtga gccgcgcgct ggggcagaac gacaccgaca gtctgagggc 12660 caccctgaac ttcttgctga ccaatagaca gcagaagatc ccggcgcaat atgcgctgtc 12720

ggccgaggag gaaaggatcc tgagatatgt gcagcagagc gtagggctgt tcctgatgca 12780 ggagggggcc acccccagcg ccgcgctgga catgaccgcg cgcaacatgg aacctagcat 12840

gtacgccgcc aaccggccgt tcatcaataa gctgatggac tacctgcacc gcgcggcggt 12900

catgaacacg gactacttta caaacgccat cctgaacccg cactggctcc cgccgccggg 12960

gttctacacg ggcgagtacg acatgcccga ccccaacgac gggttcctgt gggacgacgt 13020

ggacagcgtg gtgttctcgc cgacctttca aaagcgccag gaggcgccgc cgagcgaggg 13080 cgcggtgggg aggagcccct ttcctagctt agggagtttg catagcttgc cgggctcggt 13140

gaacagcggc agggtgagcc ggccgcgctt gctgggcgag gacgagtacc tgaacgactc 13200

gctgctgcag ccgccgcggg ccaagaacgc catggccaat aacgggatag agagtctggt 13260 ggacaaactg aaccgttgga agacctacgc tcaggaccat agggatgcgc ccgcgccgcg 13320

gcgacagcgc cacgaccggc agcggggcct ggtgtgggac gacgaggact cggccgacga 13380 tagcagcgtg ttggacttgg gcgggagcgg tggggtcaac ccgttcgcgc atctgcagcc 13440 caaactgggg cgacggatgt tttgaaatgc aaaataaaac tcaccaaggc catagcgtgc 13500

gttctcttcc ttgttagaga tgaggcgtgc ggtggtgtct tcctctcctc ctccctcgta 13560 cgagagcgtg atggcgcagg cgaccctgga ggttccgttt gtgcctccgc ggtatatggc 13620 tcctacggag ggcagaaaca gcattcgtta ctcggagctg gctccgcagt acgacaccac 13680

tcgcgtgtac ttggtggaca acaagtcggc ggacatcgct tccctgaact accaaaacga 13740 ccacagcaac ttcctgacca cggtggtgca gaacaacgat ttcacccccg ccgaggccag 13800

cacgcagacg ataaattttg acgagcggtc gcggtggggc ggtgatctga agaccattct 13860 gcacactaac atgcccaatg tgaacgagta catgttcacc agcaagttta aggcgcgggt 13920 gatggtggct aggaagcatc cagagggggt agttgaaaca gatttgagtc aggataagct 13980

tgaatatgag tggtttgagt ttaccctgcc cgagggaaac ttttccgaga ccatgaccat 14040 Page 246

Sequence_Listing.txt agacctgatg aacaacgcca tcttggaaaa ctacttgcaa gtggggcggc aaaatggcgt 14100

gctggagagc gatatcggag tcaagtttga cagcagaaat ttcaagctgg gctgggaccc 14160 ggtgaccaag ctggtgatgc caggggtcta cacctacgag gccttccacc cggacgtggt 14220

gctgctgccg ggctgcgggg tggacttcac cgagagccgc ctgagcaacc tcctgggcat 14280 tcgcaagaag caacctttcc aagagggctt cagaatcatg tatgaggatc tagaaggtgg 14340 caacatcccc gccctccttg atgtgcccaa gtacttggaa agcaagaaga aagttgaaga 14400

cgaaactaaa aatgcagctg cggctacagc cgatacaacc actaggggtg atacatttgc 14460 aactccagcg caagagacag cagctgataa gaaggtagaa gtcttgccca ttgaaaagga 14520 tgagagtggt agaagttaca acctgatcca ggggacccac gacacgctgt accgcagttg 14580

gtacctgtcc tatacctacg gggaccccga gaagggggtg cagtcgtgga cgctgctcac 14640 caccccggac gtcacctgcg gcgcggagca agtctactgg tcgctgccgg acctcatgca 14700 agacccagtc accttccgct ctacccagca agtcagcaac taccccgtgg tcggcgccga 14760

gctcatgccc ttccgcgcca agagctttta caacgacctc gccgtctact cccagctcat 14820 ccgcagctac acctccctca cccacgtctt caaccgcttc cccgacaacc agatcctctg 14880

ccgcccgccc gcgcccacca tcaccaccgt cagtgaaaac gtgcctgctc tcacagatca 14940

cgggacgcta ccgctgcgca gcagtatccg cggagtccag cgagtgaccg tcactgacgc 15000

ccgtcgccgc acctgtccct acgtctacaa ggccctgggc atagtcgcgc cgcgcgtgct 15060

ttccagtcgc accttctaaa aaaatgtcta ttctcatctc gcccagcaat aacaccggct 15120 ggggtcttac tagacccagc accatgtacg gaggagccaa gaagcgctcc cagcagcacc 15180

ccgtccgcgt ccgcggccac ttccgcgctc cctggggcgc ttacaagcgc gggcggactt 15240

ccaccgccgt gcgcaccacc gtcgacgacg tcatcgactc ggtggtcgcc gacgcgcgca 15300 actatacccc cgccccctcc accgtggacg cggtcatcga cagcgtggtg gccgacgcgc 15360

gcgactatgc cagacgcaag agccggcggc gacggatcgc caggcgccac cggagcacgc 15420 ccgccatgcg cgccgcccgg gctctgctgc gccgcgccag acgcacgggc cgccgggcca 15480 tgatgcgagc cgcgcgccgc gctgccactg cacccacccc cgcaggcagg actcgcagac 15540

gagcggccgc cgccgccgcc gcggccatct ctagcatgac cagacccagg cgcggaaacg 15600 tgtactgggt gcgcgactcc gtcacgggcg tgcgcgtgcc cgtgcgcacc cgtcctcctc 15660 gtccctgatc taatgcttgt gtcctccccc gcaagcgacg atgtcaaagc gcaaaatcaa 15720

ggaggagatg ctccaggtcg tcgccccgga gatttacgga ccaccccagg cggaccagaa 15780 accccgcaaa atcaagcggg ttaaaaaaaa ggatgaggtg gacgaggggg cagtagagtt 15840

tgtgcgcgag ttcgctccgc ggcggcgcgt aaattggaag gggcgcaggg tgcagcgcgt 15900 gttgcggccc ggcacggcgg tggtgttcac gcccggcgag cggtcctcag tcaggagcaa 15960 gcgtagctat gacgaggtgt acggcgacga cgacatcctg gaccaggcgg cggagcgggc 16020

gggcgagttc gcctacggga agcggtcgcg cgaagaggag ctgatctcgc tgccgctgga 16080 Page 247

Sequence_Listing.txt cgaaagcaac cccacgccga gcctgaagcc cgtgaccctg cagcaggtgc tgccccaggc 16140

ggtgctgctg ccgagccgcg gggtcaagcg cgagggcgag agcatgtacc cgaccatgca 16200 gatcatggtg cccaagcgcc ggcgcgtgga ggacgtgctg gacaccgtga aaatggatgt 16260

ggagcccgag gtcaaggtgc gccccatcaa gcaggtggcg ccgggcctgg gcgtgcagac 16320 cgtggacatt cagatcccca ccgacatgga tgtcgacaaa aaaccctcga ccagcatcga 16380 ggtgcagacc gacccctggc tcccagcctc cactgctacc gtctccactt ctaccgccgc 16440

cacggctacc gagcctccca ggaggcgaag atggggcgcc gccagccggc tgatgcccaa 16500 ctacgtggtg catccttcca tcatcccgac gccgggctac cgcggcaccc ggtactacgc 16560 cagccgccgg cgcccagcca gcaaacgccg ccgccgcacc gccacccgcc gccgtctggc 16620

ccccgcccgc gtgcgccgcg tgaccacgcg ccggggccgc tcgctcgttc tgcccaccgt 16680 gcgctaccac cccagcatcc tttaattcgt gtgctgtgat actgttgcag agagatggct 16740 ctcacttgcc gcctgcgcat ccccgtcccg aattaccgag gaagatcccg ccgcaggaga 16800

ggcatggcag gcagcggcct gaaccgccgc cggcggcggg ccatgcgcag gcgcctgagt 16860 ggcggctttc tgcccgcgct catccccata atcgccgcgg ccatcggcac gatcccgggc 16920

atagcttccg ttgcgctgca ggcgtcgcag cgccgttgat gtgcgaataa aagcctcttt 16980

agactctgac acacctggtc ctgtatattt ttagaatgga agacatcaat tttgcgtccc 17040

tggctccgcg gcacggcacg cggccgttca tgggcacctg gaacgagatc ggcaccagcc 17100

agctgaacgg gggcgccttc aattggagca gtgtctggag cgggcttaaa aatttcggct 17160 cgacgctccg gacctatggg aacaaggcct ggaatagtag cacggggcag ttgctaaggg 17220

aaaagctcaa agaccagaac tttcagcaga aggtggtgga cgggctggcc tcgggcatta 17280

acggggtggt ggacatcgcg aaccaggccg tgcagcgcga gataaacagc cgcctggacc 17340 cgcggccgcc cacggtggtg gagatggaag atgcaactct tccgccgccc aaaggcgaga 17400

agcggccgcg gcccgacgcg gaggagacga tcctgcaggt ggacgagccg ccctcgtacg 17460 aggaggccgt caaggccggc atgcccacca cgcgcatcat cgcgccgctg gccacgggtg 17520 taatgaaacc cgccaccctt gacctgcctc caccacccgc gcccgctcca ccgaaggcag 17580

ctcccgcggt cgtgcaggcc cccccggtgg cgaccgccgt gcgccgcgtc cccgcccgcc 17640 gccaggccca gaactggcag agcacgttgc acagtatcgt aggcctggga gtgaaaagtc 17700 tgaagcgccg ccgatgctat tgaaagagag gaaagaggac actaaaggga gagcttaact 17760

tgtatgtgcc ttaccgccag agaacgcgcg aagatggcca ccccctcgat gatgccgcag 17820 tgggcgtaca tgcacatcgc cgggcaggac gcctcggagt acctgagccc gggtctggtg 17880

cagtttgccc gcgccaccga cacgtacttc agcctgggca acaagtttag gaaccccacg 17940 gtggccccga cccacgatgt gaccacggac cggtcccagc gtctgacgct gcgcttcgtg 18000 cccgtggatc gcgaggacac cacgtactcg tacaaggcgc gcttcactct ggccgtgggc 18060

gacaaccggg tgctagacat ggccagcact tactttgaca tccgcggcgt cctggaccgc 18120 Page 248

Sequence_Listing.txt ggtcccagct tcaaacccta ctcgggcaca gcttacaaca gtctggcccc caagggtgcc 18180

cccaactcca gccagtggct tgcaaaagac accaatgctg gcgatcaagc attaaaaacc 18240 cacacacatg gcgtagctgc tatgggggga acagatatca cagcaaaggg tttgcaaatt 18300

ggtgttgaca cgactgaaaa caagaatgag cctatttatg caaatgaaat ataccagcca 18360 gaacctcagg taggagagga aaacttgcaa gatgttgaaa acttttatgg aggcagagct 18420 cttaaaaaag aaaccaaaat gaaaccttgc tatggctcgt ttgccagacc cacaaatgaa 18480

aaaggcggtc aagccaaatt tttaactgac ggcgatggtc agctaactaa aaatcatgat 18540 atcacaatga atttctttga cactcctgga ggaacagttg gtcaggatac tgaacttgaa 18600 gcagacattg ttatgtatgc tgagaatgtg catctggaaa ctccagacac gcatgtggtg 18660

tacaaaccag gaacttctga tgagagttca gaagcaaatt tggttcagca gtccatgcca 18720 aacaggccca actacatcgg cttcagggac aactttgtgg gtctcatgta ctataacagc 18780 actggcaaca tgggtgtgct ggctggtcaa gcatctcagt tgaatgctgt ggtcgacttg 18840

caagacagaa acacagagct gtcttaccag ctcttgctag attctctggg tgacagaacc 18900 agatacttta gcatgtggaa ctctgcagtg gacagttatg atcctgatgt caggattatt 18960

gaaaatcacg gtgtggaaga tgaacttcca aactattgct tcccattgga tggagctggc 19020

actaatgcta cctaccaagg tgtaaaagtt aaaaatggcc aagatggaga tgtaaacgca 19080

gattgggaaa aagatccaaa tcttgcttca cgaaaccaaa tatgcaaggg taacatcttc 19140

gccatggaga tcaacctcca ggccaacctg tggaagagtt ttctgtactc gaatgtggcc 19200 ctgtacctgc ccgactcata caagtacacg ccggccaacg tcacgctgcc cgccaatacc 19260

aacacctacg agtacatgaa cggccgcgtg gtagccccct cgctggtgga cgcctacatc 19320

aacatcggcg cccggtggtc gctggacccc atggacaacg tcaacccatt caaccaccac 19380 cgcaacgcgg gcctgcgtta ccgctccatg cttctgggca acggccgcta cgtgcccttc 19440

cacatccaag tgccccaaaa gttctttgcc atcaagaacc tgctcctgct ccccggctcc 19500 tacacctacg agtggaactt ccgcaaggat gtcaacatga tcctgcagag ttccctcgga 19560 aacgacctgc gcgtcgacgg cgcctccgtc cgcttcgaca gcgtcaacct ctacgccaca 19620

ttcttcccca tggcgcacaa caccgcctcc accctggaag ccatgctgcg caacgacacc 19680 aacgaccagt ccttcaacga ctacctctcg gccgccaaca tgctctaccc catcccggcc 19740 aaggccacca acgtgcccat ctccatcccc tcgcgcaact gggccgcctt ccgcggctgg 19800

agtttcaccc ggctcaagac caaagaaact ccctccctcg gctcgggttt cgatccctac 19860 tttgtatact cgggttccat cccctacctc gacgggacct tctacctcaa ccacaccttc 19920

aagaaggtct ccatcatgtt cgactcctcg gtcagctggc ccggcaacga ccggctgctc 19980 acgccgaacg agttcgagat caagcgcagt gtcgacgggg agggctacaa tgtggcccaa 20040 tgcaacatga ccaaggactg gttcctcgtc cagatgctct cccactacaa catcggctac 20100

cagggcttcc acgtgcccga gggctacaag gaccgcatgt actccttctt ccgcaacttc 20160 Page 249

Sequence_Listing.txt cagcccatga gcaggcaggt ggtcgatgag atcaactaca aggactacaa ggccgtcacc 20220

ctgcccttcc agcacaacaa ctcgggcttc accggctacc ttgcacccac catgcgtcag 20280 gggcagccct accccgccaa cttcccctat cctctcatcg gccagacagc cgtgccctct 20340

gtcacccaga aaaagttcct ctgcgacagg gtcatgtggc gcatcccctt ctccagcaac 20400 ttcatgtcca tgggcgccct caccgacctg ggtcagaaca tgctctatgc caactcggcc 20460 cacgcgctcg acatgacctt cgaggtggac cccatggatg agcccaccct cctctatctt 20520

ctcttcgaag ttttcgacgt ggtcagagtg caccagccgc accgcggcgt catcgaggcc 20580 gtctacctgc gcacgccctt ctccgccggc aacgccacca cctaagcatg agcggctcca 20640 gcgaacgaga gctcgcggcc atcgtgcgcg acctgggctg cgggccctac tttttgggca 20700

cccacgacaa gcgcttcccg ggcttcctcg ccggcgacaa gctggcctgc gccattgtca 20760 acacggccgg ccgcgagacc ggaggcgtgc actggctcgc cttcggctgg aacccgcgct 20820 cgcgcacctg ctacatgttc gacccatttg ggttctcgga ccgccggctc aagcagattt 20880

acagcttcga gtacgaggct atgttgcgcc gaagcgccct ggcttcctcg cccgaccgct 20940 gtctcagcct cgagcagtcc acccagaccg tgcaggggcc cgactccgcc gcctgcggac 21000

ttttctgttg catgttcttg catgccttcg tgcactggcc cgaccgaccc atggacggga 21060

accccaccat gaacttgctg acgggggtgc ccaacggcat gctacaatcg ccacaggtgc 21120

tgcccaccct ccggcgcaac caggaggagc tctaccgctt cctcgcgcgc cactcccctt 21180

actttcgctc ccaccgcgcc gccatcgaac acgccaccgc ttttgacaaa atgaaacaac 21240 tgcgtgtatc tcaataaaca gcacttttat tttacatgta ctggagtata tgcaagttat 21300

ttaaaagtcg aaggggttct cgcgctcgtc gttgtgcgcc gcgctgggga gggccacgtt 21360

gcggtactgg aacttgggct gccacttgaa ctcggggatc accagtttgg gcactggggt 21420 ctcggggaag gtctcgctcc acatgcgccg gctcatctgc agggcgccca gtatgtccgg 21480

ggcggagatc ttgaaatcgc agttggggcc ggtgctctgc gcgcgcgagt tgcggtacac 21540 ggggttgcag cactggaaca ccatcagact ggggtacttc acactggcca gcacgctctt 21600 gtcgctgatc tgatccttgt ccaggtcctc ggcgttgctc aggccgaacg gggtcatctt 21660

gcacagctgg cggcccagga agggcacgct ctgaggcttg tggttacact cgcagtgcac 21720 gggcatcagc atcatccccg cgccgcgctg catattcggg tagagggcct tgacaaaggc 21780 cgagatctgc ttgaaagctt gctgggcctt ggccccctcg ctgaaaaaca ggccgcagct 21840

cttcccgctg aactggttat tcccgcaccc ggcatcatgc acgcagcagc gcgcgtcatg 21900 gctggtcagt tgcaccacgc tccgtcccca gcggttctgg gtcaccttgg ccttgctagg 21960

ctgctccttc aacgcgcgct ggccgttctc gctggtcaca tccatctcca ccacgtggtc 22020 cttgtggatc atcaccgtcc cgtgcaaaca cttgagctgg ccttccacct cggtgcagcc 22080 gtgatcccac agggcgcagc cggtgcactc ccaattcttg tgtgcgatcc cgctgtggct 22140

gaagatgtaa ccttgcaaca ggcgacccat gacggtgcta aatgatttac tggtgctgaa 22200 Page 250

Sequence_Listing.txt ggtcagttgc agaccgcggg cctcctcgtt catccaggtc tggcacatct tttggaagat 22260

ctcggtctgc tcgggcatga gcttgtaagc atcgcgcagg ccgctgtcga cgcggtagcg 22320 ttccataagc acgttcatgg tatccatgcc cttctcccag gacgagacca gaggcagact 22380

cagggggttg cgcacgttca gaataccggg ggtcgcgggc tcgacgatgc gttttccgtc 22440 cttgccttcc ttcaacagaa ccggcggctg gctgaatccc actcccacga tcacggcatc 22500 ttcctggggc atctcttcgt cggggtctac cttggtcaca tgcttggtct ttctggcttg 22560

cttctttttt ggagggctgt ccacggggac cacgtcctcc tcggaagacc cggagcccac 22620 ccgctgatac tttcggcgct tggtgggcag aggaggtgga ggcgaggggc tcctctcctg 22680 ctccggcgga tagcgcgccg acccgtggcc ccggggcgga gtggcctctc gctccatgaa 22740

ccggcgcacg tcctgactgc cgccggccat tgtttcctag gggaagatgg aggagcagcc 22800 gcgtaagcag gagcaggagg aggacttaac cacccacgag caacccaaaa tcgagcagga 22860 cctgggcttc gaagagccgg ctcgtctaga acccccacag gatgaacagg agcacgagca 22920

agacgcaggc caggaggaga ccgacgctgg gctcgagcat ggctacctgg gaggagagga 22980 ggatgtgctg ctgaaacact tgcagcgcca gtccctcatc ctccgggacg ccctggccga 23040

ccggagcgaa acccccctca gcgtcgagga gctgtgtcgg gcctacgagc tcaacctctt 23100

ctcgccgcgc gtgcccccca aacgccagcc caacggcacc tgcgagccca acccgcgtct 23160

caacttctat cccgttttcg cggtccccga ggcccttgcc acctatcaca tttttttcaa 23220

gaaccaaaag atccccgtct cctgccgcgc caaccgcacc cgcgccgacg cgctcctcgc 23280 tctggggccc ggcgcgcgca tacctgatat cgcttccctg gaagaggtgc ccaagatctt 23340

cgaagggctc ggtcgggacg agacgcgcgc ggcgaacgct ctgaaagaaa cagcagagga 23400

agagggtcac actagcgccc tggtagagtt ggaaggcgac aacgccaggc tggccgtgct 23460 caagcgcagc gtcgagctca cccactttgc ctaccccgcc gtcaacctcc cgcccaaggt 23520

catgcgtcac atcatggatc agctcatcat gccccacatc gaagccctcg atgaaagtca 23580 ggagcagcgc cccgaggacg cccgacccgt ggtcagcgac gagatgctcg cgcgctggct 23640 cgggacccgc gagccccagg ctttggaaca gcggcgcaag ctcatgctgg ccgtggtcct 23700

ggtcaccctc gagctcgaat gcatgcgccg cttcttcagc gaccccgaga ccctgcgcaa 23760 agtcgaggag accctgcact acactttcag acacggtttc gtcaggcagg cctgcaagat 23820 ttccaacgtg gagctgacca acctggtctc ctgcctgggg atcctgcatg agaaccgcct 23880

gggacagacc gtactccact ctaccctgaa gggcgaggcg cggagggact atgtccgcga 23940 ctgcgtcttt ctctttctct gccacacatg gcaagcagcc atgggcgtgt ggcagcagtg 24000

tctcgaggac gagaacctga aggagctgga caagcttctt gctagaaacc ttaaaaagct 24060 ttggacgggc ttcgacgagc gcaccgtcgc ctcggacctg gccgagatcg tcttccccga 24120 gcgcctgagg cagacgctga aaggcgggct gcccgacttc atgagccaga gcatgttgca 24180

aaactaccgc actttcattc tcgagcgatc ggggatgctg cccgccacct gcaacgcttt 24240 Page 251

Sequence_Listing.txt cccctccgac tttgtcccgc tgagctaccg cgagtgtccc ccgccgctgt ggagccactg 24300

ctacctcttg cagctggcca actacatcgc ctaccactcg gacgtgatcg aggacgtgag 24360 cggcgagggg ctgctcgagt gccactgccg ctgcaacctg tgctccccgc accgctccct 24420

ggtctgcaac ccccagctcc ttagcgagac ccaggtcatc ggtaccttcg agctgcaagg 24480 tccgcaggag tccaccgctc cgctgaaact cacgccgggg ttgtggactt ccgcgtacct 24540 gcgcaaattt gtacccgagg actaccacgc ccatgagata aagttcttcg aggaccaatc 24600

gcggccgcag cacgcggatc tcacggcctg cgtcatcacc cagggcgcga tcctcgccca 24660 attgcacgcc atccaaaaat cccgccaaga gtttcttctg aaaaagggta gaggggtcta 24720 cctggacccc cagacgggcg aggtgctcaa cacgggtctc ccccagcatg ccgaggaaga 24780

agcaggagcc gctagtggag gagatggaag aagaatggga cagccaggca gaggaggacg 24840 aatgggagga ggagacagag gaggaagaat tggaagaggt ggaagaggag caggcaacag 24900 agcagcccgt cgccgcacca tccgcgccgg cagccccggc ggtcacggat acaacctccg 24960

cagctccggc caagcctcct cgtagatggg atcgagtgaa gggcgacggt aagcacgagc 25020 ggcagggcta ccgatcatgg agggcccaca aagccgcgat catcgcctgc ttgcaagact 25080

gcggggggaa catcgctttc gcccgccgct acctgctctt ccaccgcggg gtgaacatcc 25140

cccgcaacgt gttgcattac taccgtcacc ttcacagcta agaaaaagca agtaagagaa 25200

gtcgccggag gaggcctgag gatcgcggcg aacgagccct tgaccaccag ggagctgagg 25260

aaccggatct tccccactct ttatgccatt tttcagcaga gtcgaggtca gcagcaagag 25320 ctcaaagtaa aaaaccggtc tctgcgctcg ctcacccgca gttgcttgta ccacaaaaac 25380

gaagatcagc tgcagcgcac tctcgaagac gccgaggctc tgttccacaa gtactgcgcg 25440

ctcactctta aagactaagg cgcgcccacc cggaaaaaag gcgggaatta cctcatcgcc 25500 accttaatga gcaaggagat tcccacccct tacatgtgga gctatcagcc ccagatgggc 25560

ctggccgcgg gcgcctccca agactactcc acacgcatga actggctcag tgccggcccc 25620 tcgatgatat cacgggtcaa cggggtccgc agtcatcgaa accagatatt gttggagcag 25680 gcggcggtca cctccacgcc cagggcaaag ctcaacccgc gtaattggcc ctccaccctg 25740

gtgtatcagg aaatccccgg gccgactacc gtactacttc cgcgtgacgc actggccgaa 25800 gtccgcatga ctaactcagg tgtccagctg gccggcggcg cttcccggtg cccgctccgc 25860 ccacaatcgg gtataaaaac cctggtgatc cgaggcagag gcacacagct caacgacgag 25920

ttggtgagct cttcgatcgg tctgcgaccg gacggagtgt tccaactagc cggagccggg 25980 agatcgtcct tcactcccaa ccaggcctac ctgaccttgc agagcagctc ttcggagcct 26040

cgctcgggag gcatcggaac cctccagttc gtggaggagt ttgtgccctc ggtctacttc 26100 aaccccttct cgggatcgcc aggcctctac ccggacgagt tcataccgaa cttcgacgca 26160 gtgagagaag cggtggacgg ctacgactga atgtcccatg gtgactctgc tgagctcgct 26220

cggttgaggc atctggacca ctgccgccgc ctgcgctgct tcgcccggga gagctgcgga 26280 Page 252

Sequence_Listing.txt ctcatctact ttgagtttcc cgaggagcac cccaacggtc ctgcacacgg agtgcggatc 26340

accgtagagg gcaccaccga gtctcacctg gtcaggttct tcacccagca acccttcctg 26400 gtcgagcggg accggggcgc caccacctac accgtctact gcatctgtcc gaccccgaag 26460

ttgcatgaga atttttgctg tactctttgt ggtgagttta ataaaagcta aactcttgca 26520 atactctgga ccttgtcgtc atcaactcaa cgagaccgtc tacctcacca accagactga 26580 ggtaaaactc acctgcagac cacacaagac ctatatcatc tggttcttcg agaacacctc 26640

atttgcagtc tcaaacactc actgcaacga cggtgttgaa cttccaaaca acctttccag 26700 tggactgagt tacgatacac atagagctaa gctcgtcctc tacaatcctt tcgtagaggg 26760 aacctaccac tgccagagcg gaccttgctt ccacagtttt actttggtga acgttaccgg 26820

cagcagcaca gccgctccag aacctaacct tccttctgat actatcaaac ctcgtttcgg 26880 aggtgagcta aggcttcccc cttctgagga gggggttagc ccatacgaag tggtcgggta 26940 tttgatttta ggggtggtcc tgggtgggtg catagcggtg ctagctcagc tgccttgctg 27000

ggtagaaatc aaaatcttta tatgctgggt cagacattgt ggggaggaac tatgaagggg 27060 ctcttgctga ttatcctttc cctggtgggg ggtgtgctgt catgccacga acagccacga 27120

tgtaacatca ccacaggcaa tgagaggagt gtcatatgca cagtagtcat caaatgcgag 27180

catgaatgcc ctctcaacat cacattcaaa aaccgtacca tggggaatgc atgggtgggc 27240

gactgggaac caggagatga gcagaactac acggtcactg tccatggtag cgatggaaat 27300

cacactttcg gtttcaaatt catttttgaa gtcatgtgtg atatcacact gcatgtggct 27360 agacttcatg gcttgtggcc ccctaccaag gaaaacatgg ttgggttttc tttggctttt 27420

gtgatcatgg cctgctttat gtcaggtctg ctggtaggag ctctagtgtg gttcctgaaa 27480

cgcaagccca ggtatggaaa tgaggagaag gaaaaattgc tataaattct ttttcttttc 27540 acagcaccat gaatactttg accagtgtcg tgctgctctc tcttcttgta gcttttagtc 27600

aggcaggaat tattaactta aatgtatcat ggggaatgaa tctaacttta gtgggaccct 27660 cagacctgcc agttacatgg tatgatggaa agggaatgca gttttgtgat ggaaatacaa 27720 ttaagaaccc acaaatcaag catagctgta atcaacagaa tctaacttta cttaatgctg 27780

acaagtctca tgaaagaact tacctaggtt acagacatga cagtaaggga aaagtagact 27840 ataaggttac agtcatacca cctcctccag ccactcgcaa gcctttgtca gagcctcatt 27900 atgttactgt gactatgggc gataacataa ctttagtggg accctcagac ctgccagtta 27960

catggtatga tggagaagga aataaattct gcgatggaga aaaagttgaa catgcagaat 28020 ttaatcatac atgtaacatc cagaacctga cactgctctt tgtcaactta acgcataatg 28080

gagcatacat tggttataac aaagacggtt ctgatagaga attatatgag gtgtcagtca 28140 aaaccttgtt tcagaacggg gctggacaaa gtaaggttga acaaggtaat aaagggaaac 28200 ctaatactgc tcaaagtggt ggtaaaaaaa ccaaaacaga acatagaaac cagagtccaa 28260

aaagaaaatc aacaaataac cttcagccaa cacaattgta tgttaggcct tttactaatg 28320 Page 253

Sequence_Listing.txt ttagtttaac tggacctcca aatggcaagg ttacttggta tgatggcgaa cttaatgatc 28380

catgtgaaca aaagtacaaa ctcagaactt tttgcaatca gcaaaatcta actttaatta 28440 atgtaagcag cacttatgat ggcatctatt atggcactga tgaaaaagat aaggcaaatc 28500

gttacagaat aaaagtaaat actacaaatc acaaaactgt taaaattaag ccacatacca 28560 gagaacctcc tgctgtacaa gaaaaacagt ttgaattaca agatgcagaa actgatgaaa 28620 acgaatcaaa aattccctca gctactgtgg caatcgtggt gggagtgatt gcgggctttg 28680

taactctgat cattgtcttc atatgctaca tctgctgccg caagcgtccc aggtcataca 28740 atcatatggt agacccacta ctcagcttct cttactgaaa ctcagtcact ctcatttcag 28800 aaccatgaag gctttcacag cttgcgttct gattagcata gtcacactta gttcagctgc 28860

aatgattaat gttaatgtca ctagaggtgg taaaattaca ttgaatggga cttatccaca 28920 aactacatgg acaagatatc ataaagatgg atggaaaaat atctgtgaat ggaatgttac 28980 tgcatataaa tgcttcaata atggaagcat tactattact gccactgcca acattacttc 29040

tggcacatac aaagctgaaa gctataaaaa tgaaatcaaa aaactaacct ataaaaacaa 29100 caaaaccaca tttgaagatt ctggaaatta tgaacatcaa aaattatctt tttatatgtt 29160

gacaataatt gaactgccta caactaaggc tcccaccaca accagtacaa ctattaagac 29220

cactactcac actacagtgc aaaatactac tttattgatt gggtttttac tgagagagaa 29280

tgaaagtact actgaacaga cagaggctac ctcaagtgcc ttcagcagca ctgcaaattt 29340

aacttcgctt gcttggacta atgaaaccgg agtatcattg atgcatggcc agccttactc 29400 aggtttggat attcaaatta cttttctggt tgtctgtggg atctttattc ttgtggttct 29460

tctgtacttt gtctgctgca aagccagaga gaaatctagg aggcccatct acaggccagt 29520

gattggggaa cctcagccac tccaagtgga tggaggctta aggaatcttc tcttctcttt 29580 tacagtatgg tgatcagcca tgattcctag gttcttccta tttaacatcc tcttttgtct 29640

cttcaacatc tgtgctgcct tcgcggccgt ctcgcacgcc tcgcccgact gtctagggcc 29700 tttccccacc tacctcctct ttgccctgct cacctgcacc tgcgtctgca gcattgtctg 29760 cgtggtcatc accttcctgc agctcatcga ctggtgctgc gcgcgctata attatctcca 29820

ccacagtccc gaatacaggg acgagaacgt agccagaatc ttaaggctca tctgaccatg 29880 cagactctgc tcatgctgct atccctccta tcccctgccc tcgccacttc tgctgactct 29940 aaatgcaaat tcgcggagat atggaatttc ttagattgct atcaggagaa aattgatatg 30000

ccctcctatt acttggtgat tgtgggaata gtcatggtct gctcctgcac tttctttgcc 30060 atcatgatct acccctgttt tgatctcggc tggaactctg ttgaggcatt cacatacaca 30120

ctagaaagca gttcactagc ctccacgcca ccgcccacac cgcctccccg cagaaatcag 30180 ttcccactga ttcagtactt agaagagccc cctccccggc ccccttccac tgttagctac 30240 tttcacataa ccggcggcga tgactgacca ccacctggac ctcgagatgg acggccaggc 30300

ctccgagcag cgcatcctgc aactgcgcgt ccgtcagcag caggagcggg ccgccaagga 30360 Page 254

Sequence_Listing.txt gctcctcgat gccatcaaca tccaccagtg caagaagggc atcttctgcc ttgtcaaaca 30420

ggcaaagatc acctacgagc tcgtgtccgg cggcaagcag catcgcctca cctatgagct 30480 gccccagcag aagcagaagt tcacctgcat ggtgggcgtc aaccccatag tcatcaccca 30540

gcagtcgggc gagaccaacg gctgcatcca ctgctcctgc gaaagccccg agtgcatata 30600 ctccctcctc aagacccttt gcggactccg cgacctcctc cccatgaacg gaagcggagc 30660 tactaacttc agcctgctga agcaggctgg tgacgtcgag gagaatcctg gcccaatggt 30720

gagcaaaggc gaagagctgt tcaccggcgt ggtgcccatc ctggtggagc tggacggcga 30780 cgtgaacggc cacaagttca gcgtgagcgg cgagggcgag ggcgacgcca cctacggcaa 30840 gctgaccctg aagctgctgt gcaccaccgg caagctgccc gtgccctggc ccaccctggt 30900

gaccaccctg ggctacggcg tgcagtgctt cgcccggtac cccgaccaca tgaagcagca 30960 cgacttcttc aagagcgcca tgcccgaggg ctacgtgcag gagcggacca tcttcttcaa 31020 ggacgacggc aactacaaga cccgggccga ggtgaagttc gagggcgaca ccctggtgaa 31080

ccggatcgag ctgaagggca tcgacttcaa ggaggacggc aacatcctgg gccacaagct 31140 ggagtacaac tacaacagcc acaacgtgta catcaccgcc gacaagcaga agaacggcat 31200

caaggccaac ttcaagatcc ggcacaacat cgaggacggc ggcgtgcagc tggccgacca 31260

ctaccagcag aacaccccca tcggcgacgg ccccgtgctg ctgcccgaca accactacct 31320

gagctaccag agcgccctgt tcaaggaccc caacgagaag cgggaccaca tggtgctgct 31380

ggagttcctg accgccgccg gcatcaccga gggcatgaac gagctctata agtgatgttg 31440 attaaaagca cgaaaaccaa tcagaccctt cccccatttc cccattccca attactcata 31500

aaataaatca ttggaattaa tcattcaata aaaatcactt acttgaaatc tgaaagtatg 31560

tctctggtgt agttgttcag cagcacctcg ttaccctcct cccagctctg gtattccagt 31620 ccccggcggg cggcgaactt cctccacacc ttgaaaggga tgtcaaattc ctggtccaca 31680

attttcattg tcttccctct cagatgtcaa agaggctccg ggtggaagat gacttcaacc 31740 ccgtctaccc ctatggctac gcgcggaatc agaatatccc cttcctcact cccccctttg 31800 tctcctccga tggattccaa aacttccccc ctggggtcct gtcactcaaa ctggctgacc 31860

caatagccat cgtcaatggg aatgtctcac tcaaagtggg agggggtctc actttgcaag 31920 atggaactgg aaaactaaca gtcaatgctg atccaccttt gcaacttaca aacaacaaat 31980 tagggattgc tttggacgct ccatttgatg ttatagacaa taaactcaca ttgttagcgg 32040

gccatggctt gtctattata acaaaagaaa catcaacact gcctggcttg attaatactc 32100 ttgtagtatt aactggaaag ggtattggaa cagaatcaac agataatggc ggaagcgtat 32160

gtgttagagt tggagaaggt ggcggcttat catttaataa tgatggagac ttggtagcat 32220 ttaataaaaa agaagataag cgcaccctat ggacaactcc agacacatct ccaaattgca 32280 agattgatca agataaggac tctaagttaa ctctggtcct tacaaagtgt ggaagtcaaa 32340

tattggctaa tgtgtcatta attgtcgtag ctggtaagta caaaattatc aataacaata 32400 Page 255

Sequence_Listing.txt ctcaaccagc tctcaaagga tttaccatta aattattgtt tgatgaaaat ggagtactta 32460

tggaatcttc aaatcttggt aaatcatatt ggaactttag aaatgaaaat tcaattatgt 32520 caacagctta tgaaaaagct attggattca tgcctaattt ggtagcctat ccaaaaccta 32580

ccgctggctc taaaaaatat gcaagagata tagtttatgg aaacatctac cttggtggaa 32640 agccagatca accagtaacc attaaaacta cctttaatca ggaaactgga tgtgaatatt 32700 ctatcacatt tgattttagt tgggccaaga cttatgtaaa tgttgaattt gaaacaacct 32760

cttttacctt ttcctatatc gcccaagaat gaaagaccaa taaacgtgtt tttcatttca 32820 aaattttaat catgtatctt tattgatttt tacaccagca cgggtagtca gtctcccacc 32880 accagcccat ttcacagtgt acactgttct ctcagcacgg gtggccttaa atagggaaat 32940

gttctcatta gtgcgggaac tggacttggg gtctataatc cacacagttt cctggcgagc 33000 caaacggggg tcggtgattg agatgaagcc gtcctctgaa aagtcatcca agcgagcctc 33060 acagtccaag gtcacagtct ggtggaatga gaagaacgca cagattcata ctcggaaaac 33120

aggatgggtc tgtgcctctc catcagcgcc ctcagcagtc tctgccgccg gggctcggtg 33180 cggctgctgc agattggatc gggatcgcaa gtctctctga ctataatccc cacagccttc 33240

agcatcagtc tcctggtgcg tcgggcacag caccgcatcc tgatctctgc catgttctca 33300

cagtaagtgc agcacataat caccatgtta ttcagcagcc cataattcag ggcgctccag 33360

ccaaagctca tgttggggat gatggaaccc acgtgaccat cgtaccagat gcggcagtat 33420

atcaggtgcc tgcccctcat aaacacactg cccatataca tgatctcttt gggcatgttt 33480 ctgttcacaa tctgacggta ccaggggaag cgctggttga acatgcaccc gtaaatgact 33540

ctcctgaacc acacggccag cagggtgcct cccgcccgac actgcaggga gcccggggat 33600

gaacagtggc aatgcaggat ccagcgctcg tacccgctca ccatctgagc tctcaccaag 33660 tccagggtag cagggcacag gcacactgac atacatcttt ttaaaatttt tatttcctct 33720

ggggtcagga tcatatccca ggggactgga aactcttgga gcagggtaaa gccagcagca 33780 catggtaatc cacggacaga acttacatta tgataatctg catgatcaca atcgggcaac 33840 aggggatgtt gttcagtcag tgaagccctg gtttcctcat cagatcgtgg taaacgggcc 33900

ctgcgatatg gatgatggcg gagcgagctg gattgaatct cggtttgcat tgtagtggat 33960 tctcttgcgt accttgtcgt acttctgcca gcagaaatgg gcccttgaac agcagatacc 34020 cctcctgcgg ccgtcctttc gctgctgccg ctcagtcatc caactgaagt acatccattc 34080

tcgaagattc tggagaagtt cctctgcatc tgatgaaata aaaaacccgt ccatgcgaat 34140 tcccctcatc acatcagcca ggactctgta ggccatcccc atccagttaa tgctgccttg 34200

tctatcattc agagggggcg gtggcaggat tggaagaacc atttttattc caaacggtct 34260 cgaaggacga taaagtgcaa gtcacgcagg tgacagcgtt cccctccgct gtgctggtgg 34320 aaacagacag ccaggtcaaa acccactcta ttttcaaggt gctcgaccgt ggcttcgagc 34380

agtggctcta cgcgtacatc cagcataaga atcacattaa aggctggccc tccatcgatt 34440 Page 256

Sequence_Listing.txt tcatcaatca tcaggttaca ttcctgcacc atccccaggt aattctcatt tttccagcct 34500

tgaattatct ctacaaattg ttggtgtaag tccactccgc acatgtggaa aagctcccac 34560 agtgccccct ccactttcat aatcaggcag accttcataa tagaaacaga tcctgctgct 34620

ccaccacctg cagcgtgttc aaaacaacaa gattcaataa ggttctgccc tccgccctga 34680 gctcgcgcct caatgtcagc tgcaaaaagt cacttaagtc ctgggccact acagctgaca 34740 attcagagcc agggctaagc gtgggactgg caagcgtaag ggaaaacttt aatgctccaa 34800

agctagcacc caaaaactgc atgctggaat aagctctctt tgtgtctccg gtgatgcctt 34860 ccaaaatgtg agtgataaag cgtggtagtt tttctttaat catttgcgta atagaaaagt 34920 cctctaaata agtcactagg accccaggga ccacaatgtg gtagcttaca ccgcgtcgct 34980

gaagcatggt tagtagagat gagagtctga aaaacagaaa gcatgcacta aactaaggtg 35040 gctattttta ctgaaggaaa aatcactctc tccagcaaca gggtacccac tgggtggccc 35100 ttgcggacat acaaaaatcg gtccgtgtga ttaaaaagca gcacagtaag ttcctgtctt 35160

cttccggcaa aaatcacatc ggactgggtt agtatgtccc tggcatggta gtcattcaag 35220 gccataaatc tgccctgata tccagtagga accagcacac tcacttttag gtgaagcaat 35280

accaccccat gcggaggaat gtggaaagat tcagggcaaa agaaggtata tctattgcta 35340

gtcccttcct ggacgggagc gatccctcca ggactatcta tgaaagcata cagagattca 35400

gccatagctc agcccgctta ccagtagaca gagagcacag cagtacaagc gccaacagca 35460

gcgactgact acccactaac ccagctccct atttaaaggc accttacact gacgtaatga 35520 ccaaaggtct aaaaaccccg ccaaaaaaac acacacgccc tgggtgtttt ttcgcgaaaa 35580

cacttccgcg ttctcacttc ctcgtatcga tttcgtgact caacttccgg gttcccacgt 35640

tacgtcactt ctgcccttac atgtaactca gtcgtagggc gccatgttgc ccacgtccaa 35700 aatggtttcc atgtccagcc acgcctccgc ggcgaccgtt agccgtgcgt cgtgacgtca 35760

tttgcatcgt cttctctcgt ccaatcagcg ttggctccgc cccgaaaccg ttaaaattca 35820 aaagctcatt tgcatattaa cttttgttta ctttgtgggg tatattatat agatag 35876

<210> 23 <211> 35563 <212> DNA <213> Artificial Sequence <220> <223> Synthetic adenovirus genome Ad34 E3-14.8k-P2A-YPet

<400> 23 catcatcaat aatatacctt atagatggaa tggtgccaat atgtaaatga ggtgatttta 60

aaaattgtgg ggtgtgtggt gattggctgt ggggttaacg gctaaacggg gcggcgcggc 120 cgtgggaaaa tgacgttttg tgggggtgga gtttttttgc aagttgtcgc gggaaatgtg 180 acgcataaaa aggctttttt tctcacggaa ctactgactt ttcccacggt atttaacagg 240

aaatgaggta gttttgaccg gatgcaagtg aaaattgctg atttgcgcgc gaaaactgaa 300 Page 257

Sequence_Listing.txt tgaggaagtg tttttctgaa taatgtggta tttatggcag ggtggagtat ttgttcaggg 360

ccaggtagac tttgacccat tacgtggagg tttcgattac cgtgtttttt acctgaattt 420 ccgcgtaccg tgtcaaagtc ttctgttttt acgtaggtgt cagctgatcg ctacggtatt 480

tatacctcag ggtttgtgtc aagaggccac tcttgagtgc cagcgagaag agttttctcc 540 tctgcgccgg cagtttaata ataaaaaaat gagagatttg cgatttctgc ctcaggaaat 600 aatttctgct gagactggaa atgaaatact ggagcttgtg gtgcacgccc tgatgggaga 660

cgatccggag ccacctgtgc agctttttga gcctcctacg cttcaggaac tgtatgattt 720 agaggtagag ggatcggagg attctaatga ggaagctgtg aatggctttt ttaccgattc 780 tatgctttta gctgctaatg aaggattaga attagatccg cctttggaca ctttcgatac 840

tccaggggtg attgtggaaa gcggtacagg tgtaagaaaa ttacctgatt tgggttccgt 900 ggactgtgat ttgcactgct atgaagacgg gtttcctccg agtgatgagg aggaccatga 960 aaaggagcag tctatgcaga ctgcagcggg tgagggagtg aaggctgcca gtgttggttt 1020

tcagttggat tgcccggagc ttcctggaca tggctgtaag tcttgtgaat ttcacaggaa 1080 aaatactgga gtaaaggaac tgttatgttc gctttgttat atgagagcgc actgccactt 1140

tatttacagt aagtgtgttt aagttaaaat ttaaaggaat atgctgtttt tcacatgtat 1200

attgagtggg agttttgtgc ttcttattat aggtcctgtg tctgatgctg atgagtcacc 1260

atctcctgat tctactacct cacctcctga gattcaagca cctgttcctg tggacgtgcg 1320

caagcccatt cctgtgaagc ttaagcctgg gaaacgtcca gcagtggaaa aacttgagga 1380 cttgttacag ggtggggacg gacctttgga cttgagtaca cggaaacggc caagacaata 1440

agtgttccat atccgtgttt acttaaggtg acgtcaatat ttgtgtgaga gtgcaatgta 1500

ataaaaatat gttaactgtt cactggtttt tattgctttt tgggcgggga ctcaggtata 1560 taagtagaag cagacctgta tggttagctc ataggagctg gctttcatcc atggaggttt 1620

gggccatttt ggaagacctt agaaagacta ggcaactgtt agaggacgct tcggacggag 1680 tctccggttt ttggagattc tggttcgcta gtgaattagc tagggtagtt tttaggataa 1740 aacaggacta taaagaagaa tttgaaaagt tgttggtaga ttgcccagga ctttttgaag 1800

ctcttaattt gggccatcaa gttcacttta aagaaaaagt tttatcagtt ttagactttt 1860 caaccccagg tagaactgcc gctgctgtgg cttttcttac ttttatatta gataaatgga 1920 tcccgcagac tcatttcagc aggggatacg ttttggattt cgtagccaca gcattgtgga 1980

gaacatggaa ggttcgcaag atgaggacaa tcttaggtta ctggccagtg cagcctttgg 2040 gtgtagcggg aatcctgagg catccaccgg tcatgccagc ggttctggag gaggaacagc 2100

aagaggacaa cccgagagcc ggcctggacc ctccagtgga ggaggcggag tagctgactt 2160 gtctcctgaa ctgcaacggg tgcttactgg atctacgtcc actggacggg ataggggcgt 2220 taagagggag agggcatcta gtggtactga tgctagatct gagttggctt taagtttaat 2280

gagtcgcaga cgtcctgaaa ccatttggtg gcatgaggtc cagaaagagg gaagggatga 2340 Page 258

Sequence_Listing.txt agtttctgta ttgcaggaga aatattcact ggaacaggtg aaaacatgtt ggttggagcc 2400

tgaggatgat tgggaggtgg ccattaaaaa ttatgccaag atagctttga ggcctgataa 2460 acagtataag attactagac ggattaatat ccggaatgct tgttacatat ctggaaatgg 2520

ggctgaggtg gtaatagata ctcaagacaa ggcagttatt agatgctgca tgatggatat 2580 gtggcctgga gtagtcggta tggaagcagt aacttttgta aatgttaagt ttaggggaga 2640 tggttataat ggaatagtgt ttatggccaa taccaaactt atattgcatg gttgtagctt 2700

ttttggtttc aacaatacct gtgtagatgc ctggggacag gttagtgtac ggggatgtag 2760 tttctatgcg tgttggattg ccacagctgg cagaaccaag agtcaattgt ctctgaagaa 2820 atgcatattc caaagatgta acctgggcat tctgaatgaa ggcgaagcaa gggtccgcca 2880

ctgcgcttct acagatactg gatgttttat tttaattaag ggcaatgcca gcgtaaagca 2940 taacatgatt tgcggtgctt ccgatgagag gccttatcaa atgctcactt gtgccggtgg 3000 gcattgtaat atgctggcta ctgtgcatat tgtttcccat caacgcaaaa aatggcctgt 3060

ttttgatcac aatgtgttga ccaagtgtac catgcatgca ggtgggcgta gaggaatgtt 3120 tatgccttac cagtgtaaca tgaatcatgt gaaagtgttg ttggaaccag atgccttttc 3180

cagaatgagc ctaacaggaa tctttgacat gaacatgcaa atctggaaga tcctgaggta 3240

tgatgatacg agatcgaggg tgcgcgcatg cgaatgcgga ggcaagcatg ccaggttcca 3300

gccggtgtgt gtagatgtga ctgaagatct gagaccggat catttggtta ttgcccgcac 3360

tggagcagag ttcggatcca gtggagaaga aactgactaa ggtgagtatt gggaaaactt 3420 ggggtggggt tttcagatgg acagattgag taaaaatttg ttttttctgt ctttcagctg 3480

tcatgagtgg aaacgcttct tttaaggggg gagtcttcag cccttatctg acagggcgtc 3540

tcccatcctg ggcaggagtt cgtcagaatg ttatgggatc tactgtggat ggaagacccg 3600 tccaacccgc caattcttca acgctgacct atgctacttt aagttcttca cctttggacg 3660

cagctgcagc cgccgccgcc gcctctgttg ccgctaacac tgtgcttgga atgggttact 3720 atggaagtat cgtggctaat tccacttcct ctaataaccc ttctaccctg actcaggaca 3780 agttacttgt ccttttggcc cagctggagg ctttgaccca acgtctgggt gaactttatc 3840

agcaggtggc cgagttgcga gtacaaactg agtctgctgt cggcacggca aagtctaaat 3900 aaaaaaaaat tccacaatca atgaataaat aaacgagctt gttgttgatt taaaatcaag 3960 tgtttttatt tcatttttcg cgcacggtat gccctagacc accgatctcg atcattgaga 4020

acacggtgga ttttttccag aatcctatag aggtgggatt gaatgtttag atacatgggc 4080 attaggccat ctttggggtg gagatagctc cattgaaggg attcatgctc cggggtagtg 4140

ttgtaaatca cccagtcata acaaggtcgc agtgcatggt gttgcacaat atcttttaga 4200 agtaggctga ttgccacaga taagcccttg gtgtaggtgt ttacaaaccg gttgagctgg 4260 gaggggtgca ttcggggtga aattatgtgc attttggatt ggatttttaa gttggcaata 4320

ttgccgccaa gatctcgtct tgggttcatg ttatgaagga ccaccaagac ggtgtatccg 4380 Page 259

Sequence_Listing.txt gtacatttag gaaatttatc gtgtagcttg gatggaaaag cgtggaaaaa tttggagaca 4440

cccttgtgtc ctccgagatt ttccatgcac tcatccatga taatagcaat ggggccgtgg 4500 gcagcagcgc gggcaaacac gttccgtggg tctgacacat catagttatg ttcctgagtt 4560

aaatcatcat aagccatttt aatgaatttg gggcggagag tacccgattg gggtatgaat 4620 gttccttcgg gccccggagc atagttcccc tcacagattt gcatttccca agctttcagt 4680 tccgatggtg gaatcatgtc cacctggggg gctatgaaga acaccgtttc tggggcgggg 4740

gtgattagtt gggatgatag caagtttctg agcaattgag atttgccaca tccggtgggg 4800 ccataaatga ttccgattac aggttgcagg tggtagttta gggaacggca actgccgtct 4860 tctcgaagca agggggccac ctcgttcatc atttccctta catgcatatt ttcccgcacc 4920

aaatccatta ggaggcgctc tcctcctagt gatagaagtt cttgtagtga ggaaaagttt 4980 ttcagcggtt ttagaccgtc agccatgggc attttggaga gagtttgctg caaaagttct 5040 agtctgttcc acagttcagt gatgtgttct atggcatctc gatccagcag acctcctcgt 5100

ttcgcgggtt tggacggctc ctggagtagg gtatgagacg atgggcgtcc agcgctgcca 5160 gggttcggtc cttccagggt ctcagtgttc gagtcagggt tgtttccgtc acagtgaagg 5220

ggtgtgcgcc tgcttgggcg cttgccaggg tgcgcttcag actcattctg ctggtggaga 5280

acttctgtcg cttggcgccc tgtatgtcgg ccaagtagca gtttaccatg agttcgtagt 5340

tgagcgcctc ggctgcgtgg cctttggcgc ggagcttacc tttggaagtt ttcttgcata 5400

ccgggcagta taggcatttc agcgcataca gcttgggcgc aaggaaaatg gattctgggg 5460 agtatgcatc tgcgccgcag gaggcgcaaa cagtttcaca ttccaccagc caggttaaat 5520

ccggttcatt ggggtcaaaa acaagttttc cgccatattt tttgatgcgt ttcttacctt 5580

tggtctccat gagttcgtgt cctcgttgag tgacaaacag gctgtccgta tccccgtaga 5640 ctgattttac aggcctcttc tccagtggag tgcctcggtc ttcttcgtac aggaactctg 5700

accactctga tacaaaggcg cgcgtccagg ccagcacaaa ggaggctatg tgggaggggt 5760 agcgatcgtt gtcaaccagg gggtccacct tttccaaagt atgcaaacac atgtcaccct 5820 cttcaacatc caggaatgtg attggcttgt aggtgtattt cacgtgacct ggggtccccg 5880

ctgggggggt ataaaagggg gcggttcttt gctcttcctc actgtcttcc ggatcgctgt 5940 ccaggaacgt cagctgttgg ggtaggtatt ccctctcgaa ggcgggcatg acctctgcac 6000 tcaggttgtc agtttctaag aacgaggagg atttgatatt gacagtgccg gttgagatgc 6060

ctttcatgag gttttcgtcc atttggtcag aaaacacaat ttttttattg tcaagtttgg 6120 tggcaaatga tccatacagg gcgttggata aaagtttggc aatggatcgc atggtttggt 6180

tcttttcctt gtccgcgcgc tctttggcag cgatgttgag ttggacatac tcgcgtgcta 6240 ggcacttcca ttcggggaag atagttgtca attcatctgg cacgattctc acttgccacc 6300 ctcgattatg caaggtaatt aaatccacac tggtggccac ctcgcctcga aggggttcgt 6360

tggtccaaca gagcctacct cctttcctag aacagaaagg gggaagtggg tctagcataa 6420 Page 260

Sequence_Listing.txt gttcatcggg agggtctgca tccatggtaa agattcccgg aagtaaatcc ttatcaaaat 6480

agctgatggg agtggggtca tctaaggcca tttgccattc tcgagctgcc agtgcacgct 6540 catatgggtt aaggggactg ccccagggca tgggatgggt gagtgcagag gcatacatgc 6600

cacagatgtc atagacgtag atgggatcct caaagatgcc tatataggtt ggatagcatc 6660 gcccccctct gatacttgct cgcacatagt catatagttc atgtgatggc gctagcaacc 6720 ccggacccaa gttggtgcga ttgggttttt ctgttctgta gacaatctgg cgaaagatgg 6780

cgtgagaatt ggaagagatg gtgggtcttt gaaaaatgtt gaaatgggca tgaggtagac 6840 ctacagagtc tctgacaaag tgggcataag attcttgaag cttggttacc agttcggcgg 6900 tgacaagtac gtctagggcg cagtagtcaa gtgtttcttg aatgatgtca taacctggtt 6960

ggtttttctt ttcccacagt tcgcggttga gaaggtattc ttcgcgatcc ttccagtact 7020 cttctagcgg aaacccgtct ttgtctgcac ggtaagatcc tagcatgtag aactgattaa 7080 ctgccttgta agggcagcag cccttctcta cgggtagaga gtatgcttga gcagcttttc 7140

gcagcgaagc gtgagtaagg gcgaaggtgt ctctgaccat gactttgaga aattggtatt 7200 tgaagtccat gtcgtcacag gctccctgtt cccagagttg gaagtctacc cgtttcttgt 7260

aggcggggtt gggcaaagcg aaagtaacat cgttgaagag aatcttaccg gctctgggca 7320

taaaattgcg agtgatgcgg aaaggctgtg gtacttccgc tcgattgttg atcacctggg 7380

cagctaggac gatctcgtcg aaaccgttga tgttgtgtcc tacgatgtat aattctatga 7440

aacgcggcgt gcctttgacg tgaggtagct tattgagctc atcaaaggtt aggtctgtag 7500 ggtcagataa ggcgtagtgt tcgagagccc attcgtgcag gtgaggattt gcatgtagga 7560

atgatgacca aagatccacc gccagtgctg tttgtaactg gtcccgatac tgacgaaaat 7620

gctggccaat tgccattttt tctggagtga cacagtagaa ggttctgggg tcttgttgcc 7680 atcgatccca ctttagttta atggctagat cgtgggccat gttgacgaga cgctcttctc 7740

ctgagagttt catgaccagc atgaaaggaa ctagttgttt gccaaaggac cccatccagg 7800 tgtaagtttc cacatcgtag gtcaggaaga gtctttctgt gcgaggatga gagccgatcg 7860 ggaagaactg gatttcctgc caccagttgg aggattggct gttgatgtga tggaagtaga 7920

agtttctgcg gcgcgccgag cattcgtgtt tgtgcttgta cagacggccg cagtagtcgc 7980 agcgttgcac gggttgtatc tcgtgaatga gctgtacctg gcttcccttg acgagaaatt 8040 tcagtgggaa gccgaggcct ggcgattgta tctcgtgctc ttctatattc gctgtatcgg 8100

cctgttcatc ttctgtttcg gtggtggtca tgctgacgag cccccgcggg aggcaagtcc 8160 agacctcggc gcgggagggg cggagctgaa ggaccagagc gcgcaggctg gagctgtcca 8220

gagtcctgag acgctgcgga ctcaggttag taggtaggga cagaagatta acttgcatga 8280 tcttttccag ggcgtgcggg aggttcagat ggtacttgat ttccacaggt tcgtttgtag 8340 agatgtcaat ggcttgcagg gttccgtgtc ctttgggcgc cactaccgta cctttgtttt 8400

ttcttttgat cggtggtggc tctcttgctt cttgcatgct cagaagcgat gacggggacg 8460 Page 261

Sequence_Listing.txt cgcgccgggc ggaagcggtt gttccggacc cggaggcatg gctggtagtg gcacgtcggc 8520

gccgcgcacg ggcaggttct ggtactgcgc tctgagaaga cttgcgtgcg ccaccacgcg 8580 tcgattgacg tcttgtatct gacgtctctg ggtgaaagct accggccccg tgagcttgaa 8640

cctgaaagag agttcaacag aatcaatttc ggtatcgtta acggcagctt gtctcagtat 8700 ttcttgtacg tcaccagagt tgtcctggta ggcgatctcc gccatgaact gctcgatttc 8760 ttcctcctga agatctccgc gacccgctct ctcgacggtg gccgcgaggt cattggagat 8820

acggcccatg agttgggaga atgcagtcat gcccgcctcg ttccagacgc ggctgtaaac 8880 cacggccccc tcggagtctc ttgcgcgcat caccacctga gcgaggttaa gctccacgtg 8940 tctggtgaag accgcatagt tgcataggcg ctgaaaaagg tagttgagtg tggtggcaat 9000

gtgttcggcg acgaagaaat acatgatcca tcgtctcagc ggcatttcgc tgacatcgcc 9060 cagagcttcc aagcgctcca tggcctcgta gaagtccacg gcaaaattaa aaaactggga 9120 gtttcgcgcg gacacggtca attcctcctc gagaagacgg atgagttcgg ctatggtggc 9180

ccgtacttcg cgttcgaagg ctcccgggat ctcttcttcc tcttctatct cttcttccac 9240 taacatctct tcttcgtctt caggcggggg cggagggggc acacggcgac gtcgacggcg 9300

cacgggcaaa cggtcgatga atcgttcaat gacctctccg cggcggcggc gcatggtttc 9360

agtgacggcg cggccgttct cgcgcggtcg cagagtaaaa acaccgccgc gcatctcctt 9420

aaagtggtga ctgggaggtt ctccgtttgg gagggagagg gcgctgatta tacattttat 9480

taattggccc gtagggactg cgcgcagaga tctgatcgtg tcaagatcca cgggatctga 9540 aaacctttcg acgaaagcgt ctaaccagtc acagtcacaa ggtaggctga gtacggcttc 9600

ttgtgggcgg gggtggttat gtgttcggtc tgggtcttct gtttcttctt catctcggga 9660

aggtgagacg atgctgctgg tgatgaaatt aaagtaggca gttctaagac ggcggatggt 9720 ggcgaggagc accaggtctt tgggtccggc ttgctggata cgcaggcgat tggccattcc 9780

ccaagcatta tcctgacatc tagcaagatc tttgtagtag tcttgcatga gccgttctac 9840 gggcacttct tcctcacccg ttctgccatg catacgtgtg agtccaaacc cgcgcattgg 9900 ttgtaccagt gccaagtcag ctacgactct ttcggcgagg atggcttgct gtacttgggt 9960

gagggtggct tgaaagtcat caaaatccac aaagcggtgg taagccccgg tattaatggt 10020 gtaagcacag ttggccatga ctgaccagtt aactgtctgg tgaccagggc gcacgagctc 10080 ggtgtattta aggcgcgaat aggcgcgggt gtcaaagatg taatcgttgc aggtgcgcac 10140

cagatactgg taacctataa gaaaatgcgg cggtggttgg cggtagagag gccatcgttc 10200 tgtagctgga gcgccggggg cgaggtcttc caacataagg cggtgatagc cgtagatgta 10260

cctggacatc caggtgattc ctgcggcggt agtagaagcc cgaggaaact cgcgtacgcg 10320 gttccaaatg ttgcgtagcg gcatgaagta gttcattgta ggcacggttt gaccagtgag 10380 gcgcgcgcag tcattgatgc tctatagaca cggagaaaat gaaagcgttc agcgactcga 10440

ctccgtagcc tggaggaacg tgaacgggtt gggtcgcggt gtaccccggt tcgagacttg 10500 Page 262

Sequence_Listing.txt tactcgagcc ggccggagcc gcggctaacg tggtattggc actcccgtct cgacccagcc 10560

tacaaaaatc caggatacgg aatcgagtcg ttttgctggt tgccgaatgg cagggaagtg 10620 agtcctattt tttttttttg ccgctcagat gcatcccgtg ctgcgacaga tgcgtcccca 10680

acaacagccc ccctcgcagc agcagcaacc acaaaaggct gtccctgcaa ctactgcaac 10740 tgccgctgtg agcggtgcgg gacagcccgc ctatgatctg gacttggaag agggcgaagg 10800 actggcacgt ctaggtgcgc cttcgcccga gcggcatccg cgagttcaac tgaaaaaaga 10860

ttctcgcgag gcgtatgtgc cccaacagaa cctatttaga gacagaagcg gcgaggagcc 10920 ggaggagatg cgagcttccc gctttaacgc gggtcgtgag ctgcgtcacg gtttggacag 10980 aagacgagtg ttgcgggacg aggatttcga agttgatgaa gtgacaggga tcagtcctgc 11040

cagggcacac gtggctgcag ccaaccttgt atcggcttac gaacagacag taaaggaaga 11100 gcgtaatttc caaaagtctt ttaataatca tgtgcgaacc ctcattgccc gcgaagaagt 11160 cacccttggt ttgatgcatt tgtgggattt gatggaagct atcattcaga accctactag 11220

caaacctctg accgcacagc tgtttctggt ggtgcaacac agcagagaca atgaggcttt 11280 cagagaggcg ctgctcaaca tcaccgaacc cgaggggaga tggttgtatg atcttatcaa 11340

cattctacag agtatcatag tgcaggagcg gagcctgggc ctggccgaga aggtggctgc 11400

catcaattac tcggttttga gcttgggaaa gtattacgct cgcaagatct acaagactcc 11460

atacgttccc atagacaagg aggtgaagat agatgggttc tacatgcgca tgacgctgaa 11520

ggtgttgacc ctgagcgatg atcttggggt gtaccgcaat gacagaatgc atcgcgcggt 11580 gagcgccagc aggaggcgcg agttaagcga cagggaactg atgcacagtt tgcaaagagc 11640

tctaactgga gctggaaccg agggtgagaa ttactttgat atgggagctg acttgcagtg 11700

gcagcctagt cgcagggctc tgaacgccgc gacggcagga tgtgagcttc cttacataga 11760 agaggcggat gaaggcgagg aggaagaggg cgagtacttg gaagactgat ggcacaaccc 11820

gtgttttttg ctagatggaa cagcaagcac cggatcccgc aatgcgggcg gcgctgcaga 11880 gccagccgtc cggcattaac tcctcggacg attggaccca ggccatgcaa cgtatcatgg 11940 cgttgacgac tcgcaacccc gaagccttta gacagcaacc ccaggccaac cgtctatcgg 12000

ccatcatgga agctgtagtg ccttcccgct ctaatcccac tcatgagaag gtcctggcca 12060 tcgtgaacgc gttggtggag aacaaagcta ttcgtccaga tgaggccgga ctggtataca 12120 acgctctctt agaacgcgtg gctcgctaca acagtagcaa tgtgcaaacc aatttggacc 12180

gtatgataac agatgtacgc gaagccgtgt ctcagcgcga aaggttccag cgcgatgcca 12240 acctgggttc gctggtggcg ttaaatgctt tcttgagtac tcagcctgct aatgtgccgc 12300

gtggtcaaca ggattatact aactttttaa gtgctttgag actgatggta tcagaagtac 12360 ctcagagcga agtatatcag tccggtcctg attacttctt tcagactagc agacagggct 12420 tgcagacggt aaatctgagc caagctttta aaaaccttaa aggtttgtgg ggagtgcatg 12480

ccccggtagg agaaagagca accgtgtcta gcttgttaac tccgaactcc cgcctattat 12540 Page 263

Sequence_Listing.txt tactgttggt agctcctttc accgacagcg gtagcatcga ccgtaattcc tatttgggtt 12600

acctactaaa cctgtatcgc gaagccatag ggcaaagtca ggtggacgag cagacctatc 12660 aagaaattac ccaagtcagt cgcgctttgg gacaggaaga cactggcagt ttggaagcca 12720

ctctgaactt cttgcttacc aatcggtctc aaaagatccc tcctcaatat gctcttactg 12780 cggaggagga gaggatcctt agatatgtgc agcagagcgt gggattgttt ctgatgcaag 12840 agggggcaac tccgactgca gcactggaca tgacagcgcg aaatatggag cccagcatgt 12900

atgccagtaa ccgacctttc attaacaaac tgctggacta cttgcacaga gctgccgcta 12960 tgaactctga ttatttcacc aatgccatct taaacccgca ctggctgccc ccacctggtt 13020 tctacacggg cgaatatgac atgcccgacc ctaatgacgg atttctgtgg gacgacgtgg 13080

acagcgatgt tttttcacct ctttctgatc atcgcacgtg gaaaaaggaa ggcggcgata 13140 gaatgcattc ttctgcatcg ctgtccgggg tcattggtgc taccgcggct gagcccgagt 13200 ctgcaagtcc ttttcctagt ctaccctttt ctctacacag tgtacgtagc agcgaagtgg 13260

gtagaataag tcgcccgagt ttaatgggcg aagaggagta cctaaacgat tccttgctca 13320 gaccggcaag agaaaaaaat ttcccaaaca atggaataga aagtttggtg gataaaatga 13380

gtagatggaa gacttatgct caggatcaca gagacgagcc tgggatcatg gggactacaa 13440

gtagagcgag ccgtagacgc cagcgccatg acagacagag gggtcttgtg tgggacgatg 13500

aggattcggc cgatgatagc agcgtattgg acttgggtgg gagaggaagg ggcaacccgt 13560

ttgctcattt gcgccctcgc ttgggtggta tgttgtaaaa aaaaataaaa aagaaaaaac 13620 tcaccaaggc catggcgacg agcgtacgtt cgttcttctt tattatctgt gtctagtata 13680

atgaggcgag tcgtgctagg cggagcggtg gtgtatccgg agggtcctcc tccttcgtac 13740

gagagcgtga tgcagcagca gcaggcgacg gcggtgatgc aatccccact ggaggctccc 13800 tttgtgcctc cgcgatacct ggcacctacg gagggcagaa acagcattcg ttactcggaa 13860

ctggcacctc agtacgatac caccaggttg tatctggtgg acaacaagtc ggcggacatt 13920 gcttctctga actatcagaa tgaccacagc aacttcttga ccacggtggt gcaaaacaat 13980 gactttaccc ctacggaagc cagcacccag accattaact ttgatgaacg atcgcggtgg 14040

ggcggtcagc taaaaaccat catgcatact aacatgccca acgtgaacga gtatatgttt 14100 agtaacaagt tcaaagcgcg tgtgatggtg tccagaaaac ctcctgaggg tgttagagta 14160 gacgataatt atgatcataa gcaagatatt ctaaaatacg agtggttcga gtttactttg 14220

ccagaaggca acttttcggt cactatgact atcgacttga tgaacaatgc catcatagac 14280 aattacttga aagtgggcag acagaatgga gtgttggaaa gtgacattgg tgttaagttc 14340

gacactagga acttcaagtt gggatgggat ccagaaacta agttgatcat gcctggggtt 14400 tacacctatg aggccttcca tcctgacatc gtattgctgc ctggctgcgg agtggacttt 14460 accgaaagcc gtctgagcaa ccttcttggc attagaaaga aacacccatt ccaagagggt 14520

tttaagatct tgtatgagga tttagaagga ggaaatattc cagccctttt ggatgtagat 14580 Page 264

Sequence_Listing.txt gcttatgaga acagcaagaa agatcaaaaa gccaaaatag aagctgctgc agaagctaaa 14640

gcaaacatag ttgccaacga tccggtaagg gtggctaacg ctagtgaaat caggggagac 14700 agttttgccg caacatccgt tccgactaaa gaatcattat tggatgatgt gtctcaaaac 14760

atagagttaa aactcactat taagcctgtg gaaaaagatg gcaaaaacag aagttacaat 14820 gtgttggaag ataaaatcaa cacggcctat cgcagttggt acctttcgta caattatggc 14880 gaccccgaaa aaggagtgcg ttcctggaca ttgctcacca cctcagatgt cacctgcgga 14940

gcggagcagg tctactggtc gcttccagac atgatgcagg atcctgtcac tttccgctcc 15000 actagacaag tcagtaacta ccctgtggtg ggtgcagagc ttatgcccgt cttttcaaag 15060 agcttctaca acgaacaagc tgtgtactcc cagcagctcc gccagtccac ctcgcttacg 15120

cacgtcttca accgctttcc tgagaaccag attttaatcc gtccgccggc gcccacaatt 15180 accaccgtca gtgaaaacgt tcctgctctc acagatcacg ggaccctgcc gttgcgcagc 15240 agtatccggg gagtccaacg tgtgaccgtt actgacgcca gacgccgcac ctgtccctac 15300

gtgtacaagg cactgggcat agtcgcaccg cgcgtccttt caagccgcac tttctaaaaa 15360 aaaaaaaaaa atgtccgttc ttatctcgcc cagtaataac accggttggg gtctgcgcgc 15420

tcccagcaag atgtacggag gcgcacgcaa acgttctacc caacatcccg tgcgtgttcg 15480

cgggcatttt cgcgctccat ggggtgccct caagggccgc actcgcgttc gaaccaccgt 15540

cgatgatgta atcgatcagg tggttgccga cgcccgtaat tatactccta ctgcgcctac 15600

atctactgtg gacgcagtta ttgacagtgt agtggctgac gctcgcaact atgctcgacg 15660 taagagccgg cgaaggcgca ttgccagacg tcaccgagct accactgcca tgcgagcagc 15720

aagagctctg ctacgaagag ctagacgcgt ggggcgaaga gccatgctta gggcggccag 15780

acgtgcagct tcgggcgcca gcgccggcag gtcccgcagg caagcagccg ctgtcgcagc 15840 ggcgactatt gccgacatgg cccaatcgcg aagaggcaat gtatactggg tgcgtgacgc 15900

tgccaccggt caacgtgtac ccgtgcgcac ccgtccccct cgcacttaga agatactgag 15960 cagtctccga tgttgtgtcc cagcggcgag gatgtccaag cgcaaataca aggaagaaat 16020 gctgcaggtt atcgcacctg aagtctacgg ccaaccgttg aaggatgaaa aaaaaccccg 16080

caaaatcaag cgggtaaaaa aggacaaaaa agaagaggaa gatggcgatg atgggctggc 16140 ggagtttgtg cgcgagtttg ccccacggcg acgcgtgcaa tggcgtgggc gcaaagttcg 16200 acatgtgttg agacctggaa cttcggtggt ctttacaccc ggcgagcgtt caagcgctac 16260

ttttaagcgt tcctatgatg aggtgtacgg ggatgatgat attcttgagc aggcagctga 16320 ccgattaggc gagtttgctt atggcaagcg tagtagaata aatcccaagg atgaaacagt 16380

gtccataccc ttggatcatg gaaatcccac ccctagtctt aaaccggtca ctttgcagca 16440 agtgttaccc gtaactccgc gaacaggtgt taaacgcgaa ggtgaagatt tgtatcccac 16500 tatgcaactg atggtgccca aacgccagaa gttggaggac gttttggaga aagtaaaagt 16560

ggatccagat attcaacctg aggttaaagt gagacccatt aagcaggtag cgcctggtct 16620 Page 265

Sequence_Listing.txt gggagtacaa actgtagaca ttaaaattcc cactgaaagt atggaagtgc aaactgaacc 16680

cgcaaagcct actgccacct ccactgaagt gcaaacggac ccatggatgc ccatgcctat 16740 tacaactgac gccgtcggtc ccactcgaag atcccgacga aagtacggtc cagcaagtct 16800

gttgatgccc aactatgtcg tacacccatc tattattcct actcctggtt accgaggcac 16860 tcgctactat cgcagccgaa acagtacttc ccgccgtcgc cgcaagacac ctgcaaatcg 16920 cagtcgtcgc cgtagacgca caagcaaacc gattcccggc gccctggtgc ggcaagtgta 16980

ccgcaatggt agtgcggaac ctttgacact gccgcgtgcg cgttaccatc ctagtatcat 17040 cacttaatca atgttgccgc tgcctccttg cagatatggc cctcacttgt cgccttcgcg 17100 ttcccatcac tggttaccga ggaagaaact cgcgccgtag aagagggatg ttggggcgcg 17160

gaatgcgacg ctacaggcga cggcgtgcta tccgcaagca attgcggggt ggttttttgc 17220 cagccttaat tccaattatc gctgctgcga ttggcgcaat accaggcata gcttccgtgg 17280 cggttcaggc ctcgcaacga cattgacatt ggaaaaaaaa aaaacgtata aataaaaaat 17340

acaatggact ctgacactcc tggtactgtg actatgtttt cttagagatg gaagacatca 17400 atttttcatc cttggctccg cgacacggca cgaagccgta catgggcacc tggagcgaca 17460

tcggcacgag ccaactgaac gggggcgcct tcaattggag cagtatctgg agcgggctta 17520

aaaattttgg ctcaaccata aaaacatacg ggaacaaagc ttggaacagc agtacaggac 17580

aggcgcttag aaataaactt aaagaccaga acttccaaca aaaagtagtc gatgggatag 17640

cttccggtat caatggagtg gtagatttgg ctaaccaggc tgtgcagaaa aagataaaca 17700 gtcgtttgga cccgccgcca gcaaccccag gtgaaatgca agtggaggaa gaaattcctc 17760

cgccagaaaa acgaggcgac aagcgtccgc gtcccgattt ggaagagacg ctggtgacgc 17820

gcgtagatga accgccttct tatgaggaag caacgaagct tggaatgccc accactagac 17880 cgatagcccc tatggccacc ggggtgatga aaccttctca gttgcatcga cccgtcacct 17940

tggatttgcc ccctcctcct gctgctactg ctgtacccgc ttctaagcct gtcgctgccc 18000 cgaaaccagt cgccgtagcc aggtcacgtc ccgggggcgc tcctcgtcca aatgcacact 18060 ggcaaaatac tctgaacagc atcgtgggtc taggcgtgca aagtgtaaaa cgccgtcgct 18120

gcttttaatt aaatatggag tagcgcttaa cttgcctatc tgtgtatatg tgtcattaca 18180 cgccgtcaca gcatcagagg aaaaaaggaa gaggtcgtgc gtcgacgctg agttactttc 18240 aagatggcca ccccatcgat gctgccccaa tgggcataca tgcacatcgc cggacaggat 18300

gcttcggagt acctgagtcc gggtctggtg cagttcgccc gcgccacaga cacctacttc 18360 aatctgggaa ataagtttag aaatcctacc gtagcgccga cccacgatgt gaccaccgat 18420

cgtagccagc ggctcatgtt gcgcttcgtg cccgttgacc gggaggacaa tacatactct 18480 tacaaagtgc ggtacaccct ggccgtgggc gacaacagag tgctggatat ggccagcacg 18540 ttctttgaca ttaggggcgt gttggacaga ggtcccagtt ttaaacccta ttctggtacg 18600

gcttacaact ccctggctcc taaaggcgct ccaaatgcat ctcagtggtt ggataaggga 18660 Page 266

Sequence_Listing.txt gttacaagca ctggcctagt ggacgacggc aatactgatg atggggaaga agccaaaaaa 18720

gcaacataca cttttggtaa tgctccagta aaagccgagg ctgaaatcac aaaagacgga 18780 ttgccggtgg gcttggaagt ttcaactgaa ggtcctaaac caatctatgc tgataagctt 18840

tatcagccag aacctcaagt gggagacgaa acttggactg acctagacgg aaaaaccgaa 18900 gagtatggag ggagggttct taaacctgaa actaaaatga aaccctgcta cggatctttt 18960 gctaaaccta ctaatattaa aggaggtcag gcaaaggtaa aaccaaaaga agacgatggc 19020

actaacaaca tcgagtatga cattgacatg aacttctttg acttaagatc acaaagatca 19080 gaactcaaac ctaaaattgt aatgtatgca gaaaatgtgg acctggaatg tccagatact 19140 catgttgtgt acaaacctgg agtttcagat gctagttctg agaccaatct tggacaacag 19200

tctatgccca acagacccaa ctacattggc ttcagagata acttcatcgg acttatgtac 19260 tataacagta ctggcaacat gggggtactg gctggccaag cgtctcagtt gaatgcagtg 19320 gttgacttgc aggacagaaa cacagaactg tcttaccaac tcttgcttga ctctctgggc 19380

gacagaacca gatactttag catgtggaat caggctgtgg acagttatga tcctgatgta 19440 cgtgttattg aaaatcatgg tgtggaagat gaacttccca actattgttt tccgttggat 19500

ggtgtcggtc cgcgaacaga tagttacaag gagattaagc caaatggaga ccaatctact 19560

tggacaaatg tagacccaac tggcagcagt gaacttgcta agggaaatcc atttgccatg 19620

gaaattaacc ttcaagccaa tctatggcga agtttccttt attccaatgt ggctctatat 19680

ctcccagact cgtacaaata caccccgtcc aatgtcactc ttccagaaaa caaaaacacc 19740 tacgactaca tgaacgggcg ggtggtgccg ccatctctag tagacaccta tgtgaacatt 19800

ggtgccaggt ggtctctgga tgccatggac aatgtcaacc cattcaacca ccaccgtaac 19860

gctggcttgc gttaccgatc catgcttctg ggtaacggac gttatgtgcc tttccacata 19920 caagtgcctc aaaaattctt cgctgttaaa aacctgctgc ttctcccagg ctcctacact 19980

tatgagtgga actttaggaa ggatgtaaac atggttctac agagttccct cggtaacgac 20040 ctacgggtag atggcgccag catcagtttt acgagcatca acctctatgc tacttttttc 20100 cccatggctc acaacaccgc ttccaccctt gaagccatgc tgcggaatga caccaatgat 20160

cagtcattca acgactacct atctgcagct aacatgctct accccattcc tgccaatgca 20220 accaatattc ccatttccat tccttctcgc aactgggcgg ctttcagagg ctggtcattt 20280 accagactga aaaccaaaga aactccctct ttggggtctg gatttgaccc ctacttcgtc 20340

tattctggtt ctattcccta cctggatggt accttctacc tgaaccacac ttttaagaag 20400 gtttccatca tgtttgactc ttcagtgagc tggcctggaa atgacaggtt actatctcct 20460

aacgaatttg aaataaagcg cactgtggat ggcgaaggct acaacgtagc ccaatgcaac 20520 atgaccaaag actggttctt ggtacagatg ctcgccaact acaacatcgg ctatcagggc 20580 ttctacattc cagaaggata caaagatcgc atgtattcat ttttcagaaa cttccagccc 20640

atgagcaggc aggtggttga tgaggtcaat tacaaagact tcaaggccgt cgccataccc 20700 Page 267

Sequence_Listing.txt taccaacaca acaactctgg ctttgtgggt tacatggctc cgaccatgcg tcaaggtcaa 20760

ccctatcccg ctaactatcc ctatccactc attggaacaa ctgccgtaaa tagtgttacg 20820 cagaaaaagt tcttgtgtga cagaaccatg tggcgcatac cgttctcaag caacttcatg 20880

tctatgggag cccttacaga cttgggacag aacatgctct atgccaactc agctcatgct 20940 ctggacatga cctttgaggt ggatcccatg gatgagccca ccctgcttta tcttctcttc 21000 gaagttttcg acgtggtcag agtgcatcag ccacaccgcg gcatcatcga ggcagtctac 21060

ctgcgtacac cgttctcggc cggtaacgct accacgtaag aagcttcttg cttcttgcaa 21120 acagcagctg caaccatggc ctgcggatcc caaaacggct ccagcgagca agagctcaga 21180 gccattgtcc aagacctggg ttgcggacca tattttttgg gaacctttga taagcgcttc 21240

ccggggttca tggcccccga taagctcgcc tgtgccattg taaatacggc cggacgtgag 21300 acggggggag agcactggtt ggctttcggt tggaacccac gttctaacac ctgctacctt 21360 tttgatcctt ttggattctc ggatgatcgt ctcaaacaga tttaccagtt tgaatatgag 21420

ggtctcctgc gccgcagcgc tcttgctacc aaggaccggt gtattacgct ggaaaaatct 21480 acccagaccg tgcagggccc ccgttctgcc gcctgcggac ttttctgctg catgttcctt 21540

catgcctttg tgcactggcc tgaccgtccc atggacggaa accccaccat gaaattgcta 21600

actggagtgc caaacaacat gcttcattct cctaaagtcc agcccaccct gtgtgacaat 21660

caaaaagcac tctaccattt tctcaatacc cattcgcctt attttcgctc tcatcgtaca 21720

cacatcgaaa gggccactgc gttcgaccgt atggatgtgc aataatgatt catgtaaaca 21780 acgtgttcaa taaacagcac tttatttttt acatgtatcg aggctctgga ttacttattt 21840

atttacaagt cgaatgggtt ctgacgagaa tcagaatgac ccgcaggcag tgatacgttg 21900

cggaactgat acttgggttg ccacttgaat tcgggaatca ccaacttggg aaccggtata 21960 tcgggcagga tgtcactcca cagctttctg gtcagctgca aagctcccag caggtcagga 22020

gccgaaatct tgaaatcaca attaggacca gtgctctgag cgcgagagtt gcggtacacc 22080 ggattgcagc actgaaacac catcagcgac ggatgtctta cgcttgccag cacggtggga 22140 tctgcaatca tgcccacatc cagatcttca gcattggcaa tgctgaacgg ggtcatcttg 22200

caggtctgcc tacccatggc gggcacccaa ttaggcttgt ggttacaatc gcagtgcagg 22260 gggatcagta tcatcttggc ctgatcctgt ctgattcctg gatacacggc tctcatgaaa 22320 gcatcatatt gcttgaaagc ctgctgggct ttactaccct cggtataaaa catcccgcag 22380

gacctgctcg aaaactggtt agctgcgcag ccggcatcat tcacacagca gcgggcgtca 22440 ttgttggcta tttgcaccac acttctgccc cagcggtttt gggtgatttt ggttcgctcg 22500

ggattctcct tcaaggctcg ttgtccgttc tcgctggcca catccatctc gataatctgc 22560 tccttctgaa tcataatatt gccatgcaag cacttcagct tgccctcata atcattgcag 22620 ccatgaggcc acaacgcaca gcctgtacat tcccaattat ggtgggcgat ctgagaaaaa 22680

gaatgtatca ttccctgcag aaatcttccc atcatcgtgc tcagtgtctt gtgactagtg 22740 Page 268

Sequence_Listing.txt aaagttaact ggatgcctcg gtgctcctcg ttcacgtact ggtgacagat gcgcttgtat 22800

tgttcgtgct gctcaggcat tagtttaaaa gaggttctaa gttcgttatc cagcctgtac 22860 ttctccatca gcagacacat cacttccatg cctttctccc aagcagacac caggggcaag 22920

ctaatcggat tcttaacagt gcaggcagca gctcctttag ccagagggtc atctttggcg 22980 atcttctcaa tgcttctttt gccatccttc tcaacgatgc gcacgggcgg gtagctgaaa 23040 cccactgcta caagttgcgc ctcttctctt tcttcttcgc tgtcttgact gatgtcttgc 23100

atggggacat gtttggtctt ccttggcttc tttttcgggg gtatcggagg aggaggactg 23160 tcgctccgtt ccggagacag ggaggattgt gacgtttcgc tcaccattac caactgactg 23220 tcggtagaag aacctgaccc cacacggcga caggtgtttc tcttcggggg cagaggtgga 23280

ggcgattgcg aagggctgcg gtccgacctg gaaggcggat gactggcaga accccttccg 23340 cgttcggggg tgtgctccct gtggcggtcg cttaactgat ttccttcgcg gctggccatt 23400 gtgttctcct aggcagagaa acaacagaca tggaaactca gccattgctg tcaacatcgc 23460

cacgagtgcc atcacatctc gtcctcagcg acgaggaaaa ggagcagagc ttaagcattc 23520 caccgcccag tcctgccacc acctctaccc tagaagataa ggaggtcgac gcatctcatg 23580

acatgcagaa taaaaaagcg aaagagtctg agccagacat cgaacaagac ccgggctatg 23640

tgacaccggt ggaacacgag gaagagttga aacgctttct agagagagag gatgaaaact 23700

gcccaaaaca gcaagcggat aactatcacc aagatgctgg aaatagggat cagaacaccg 23760

actacctcat agggcttgac ggggaagacg cgctccttaa acatctagca agacagtcac 23820 tcatagtcaa ggatgcatta ttggacagaa ctgaagtgcc catcagtgtc gaagagctca 23880

gccgcgccta cgagcttaac ctattttcac ctcgtactcc ccccaaacgt cagccaaacg 23940

gcacctgcga gccaaatcct cgcttaaact tttatccagc ttttgctgtg ccagaagtac 24000 tggctaccta tcacatcttt tttaaaaatc aaaaaattcc agtctcctgc cgcgctaatc 24060

gcacccgcgc cgatgcccta ctcaatctgg gacctggttc acgcttacct gatatagctt 24120 ccttggaaga ggttccaaag atcttcgagg gtctgggcaa taatgagact cgggccgcaa 24180 atgctctgca aaagggagaa aatggcatgg atgagcatca cagcgttctg gtggaattgg 24240

aaggcgataa tgccagactc gcagtactca agcgaagcgt cgaggtcaca cactttgcat 24300 accccgctgt caacctgccc cctaaagtca tgacggccgt catggaccag ttactcatta 24360 agcgcgcaag tcccctttca gaagacatgc atgacccaga tgcctgtgat gagggtaaac 24420

cagtggtcag tgatgagcag ctaacccgat ggctgggcac cgactctccc cgggatttgg 24480 aagagcgtcg caagcttatg atggccgtgg tgctggttac cgtagaacta gagtgtcttc 24540

ggcgtttctt taccgattca gaaaccttgc gcaaactcga agagaatctg cactacactt 24600 ttagacacgg ctttgtgcgg caggcatgca agatatctaa cgtggaactc accaacctgg 24660 tttcctacat gggtattctg catgagaatc gcctaggaca aagcgtgctg cacagcaccc 24720

ttaaggggga agcccgccgt gattacatcc gcgattgtgt ttatctctac ctgtgccaca 24780 Page 269

Sequence_Listing.txt cgtggcaaac cggcatgggt gtatggcagc aatgtttaga agaacagaac ctgaaagagc 24840

taaacaagct cttacagaaa tctcttaagg ttctgtggac agggttcgac gagcgcaccg 24900 tcgcttccga cctggcagac ctcatcttcc cagagcgtct cagggttact ttgcgaaacg 24960

gactgcctga ctttatgagc cagagcatgc ttaacaattt tcgctctttc atcctggaac 25020 gctccggtat cctgcccgcc acctgctgcg cactgccctc cgactttgtg cctctcacct 25080 accgcgaatg ccccccgccg ctatggagtc actgctacct gttccgtctg gccaactacc 25140

tctcctacca ctcggatgtg atcgaggatg tgagcggaga cggcttgctg gagtgtcact 25200 gccgctgcaa tctgtgcacg ccccaccggt ccctagcttg caacccccag ttgatgagcg 25260 aaacccagat aataggcacc tttgaattgc aaggccccag cagccaaggc gatgggtctt 25320

ctcctgggca aagtttaaaa ctgaccccgg gactgtggac ctccgcctac ttgcgcaagt 25380 ttgccccgga agattaccac ccctatgaaa tcaagttcta tgaggaccaa tcacagcctc 25440 cgaaagccga actttcggcc tgcgtcatca cccagggggc aattctggcc caattgcaag 25500

ccatccaaaa atcccgccaa gaatttctac tgaaaaaggg taagggggtc taccttgacc 25560 cccagaccgg cgaggaactc aacacaaggt tccctcagga tgtcccaacg acgagaaagc 25620

aagaagttga aggtgcagcc gccgccccca gaagatatgg aggaagattg ggacagtcag 25680

gcagaggaag cggaggagga ggacagtctg gaggacagtc tggaggaaga cagtttggag 25740

gaggaaaacg aggaggcaga ggaggtggaa gaagtaaccg ccgacaaaca gttatcctcg 25800

gctgcggaga caagcaacag cgctaccatc tccgctccga gtcgaggaac ccggcggcgt 25860 cccagcagta gatgggacga gaccggacgc ttcccgaacc caaccagcgc ttccaagacc 25920

ggtaagaagg atcggcaggg atacaagtcc tggcgggggc ataagaatgc catcatctcc 25980

tgcttgcatg agtgcggggg caacatatcc ttcacgcggc gctacttgct attccaccat 26040 ggggtgaact ttccgcgcaa tgttttgcat tactaccgtc acctccacag cccctactat 26100

agccagcaaa tcccggcagt ctcgacagat aaagacagcg gcggcgacct ccaacagaaa 26160 accagcagcg gcagttagaa aatacacaac aagtgcagca acaggaggat taaagattac 26220 agccaacgag ccagcgcaaa cccgagagtt aagaaatcgg atctttccaa ccctgtatgc 26280

catcttccag cagagtcggg gccaagagca ggaactgaaa ataaaaaacc gatctctgcg 26340 ttcgctcacc agaagttgtt tgtatcacaa gagcgaagat caacttcagc gcactctcga 26400 ggacgccgag gctctcttca acaagtactg cgcgctgact cttaaagagt aggcagcgac 26460

cgcgcttatt caaaaaaggc gggaattaca tcatcctcga cgtttatgag taaagaaatt 26520 cccacgcctt acatgtggag ttatcagccc caaatgggat tggcggcagg cgcctcccag 26580

gactactcca cccgcatgaa ttggctcagc gccgggcctt ctatgatttc tcgagttaat 26640 gatatacgcg cctaccgaaa ccaaatactt ttggaacagt cagctcttac caccacgccc 26700 cgccaacacc ttaatcccag aaattggccc gccgccctag tgtaccagga aagtcccgct 26760

cccaccactg tattacttcc tcgagacgcc caggccgaag tccaaatgac taatgcaggt 26820 Page 270

Sequence_Listing.txt gcgcagttag cgggcggctc caccctatgt cgtcacaggc ctcggcataa tataaaacgc 26880

ctgatgatca gaggccgagg tatccagctc aacgacgagt cggtgagctc tccgcttggt 26940 ctacgaccag acggaatctt tcagattgcc ggctgcggga gatcttcctt cacccctcgt 27000

caggctgttc tgactttgga aagttcgtct tcgcaacccc gctcgggcgg aatcgggacc 27060 gttcaatttg tggaggagtt tactccctct gtctacttca accccttctc cggatctcct 27120 gggcactacc cggacgagtt cataccgaac ttcgacgcga ttagcgagtc agtggacggc 27180

tacgattgat gtctggtgac gcggctgagc tatctcggct gcgacatcta gaccactgcc 27240 gccgctttcg ctgctttgcc cgggaactca ttgagttcat ctacttcgaa ctccccaagg 27300 atcaccctca aggtccggcc cacggagtgc ggattactat cgaaggcaaa atacactctc 27360

gcctgcaacg aattttctcc cagcggcccg tgctgatcga gcgagaccag ggaaacacca 27420 cggtttccat ctactgcatt tgtaatcacc ccggattgca tgaaagcctt tgctgtctta 27480 tgtgtactga gtttaataaa aactgaatta agactctcct acggactgcc gcttcttcaa 27540

cccggatttt acaaccagaa gaacgaaact tttcctgtcg tccaggactc tgttaacttc 27600 acctttccta ctcacaaact agaagctcaa cgactacacc gcttttccag aagcattttc 27660

cctactaata ctactttcaa aaccggaggt gagctccaag gtcttcctac agaaaaccct 27720

tgggtggaag cgggccttgt agtgctagga attcttgcgg gtgggcttgt gattattctt 27780

tgctacctat acacaccttg cttcactttc ctagtggtgt tgtggtattg gtttaaaaaa 27840

tggggcccat actagtcttg cttgttttac tttcgctttt ggaaccgggt tctgccaatt 27900 acgatccatg tctagacttc gacccagaaa actgcacact tacttttgca cccgacacaa 27960

gccgcatctg tggagttctt attaagtgcg gatgggaatg caggtccgtt gaaattacac 28020

acaataacaa aacctggaac aataccttat ccaccacatg ggagccagga gttcccgagt 28080 ggtacactgt ctctgtccga ggtcctgacg gttccatccg cattagtaac aacactttca 28140

ttttttctga aatgtgcgat ctggccatgt tcatgagcaa acagtattct ctatggcctc 28200 ctagcaagga caacatcgta acgttctcca ttgcttattg cttgtgcgct tgccttctta 28260 ctgctttact gtgcgtatgc atacacctgc ttgtaaccac tcgcatcaaa aacgccaata 28320

acaaagaaaa aatgccttaa cctctttctg tttacagaca tggcttctct tacatctctc 28380 atatttgtca gcattgtcac tgccgctcac ggacaaacag tcgtctctat ccctctagga 28440 cataattaca ctctcatagg acccccaatc acttcagagg tcatctggac caaactggga 28500

agcgttgatt actttgatat aatctgcaac aaaacaaaac caataatagt aacttgcaac 28560 atacaaaatc ttacattgat taatgttagc aaagtttaca gcggttacta ttatggttat 28620

gacagataca gtagtcaata tagaaattac ttggttcgtg ttacccagtt aaaaaccacg 28680 aaaatgccaa atatggcaaa gattcgatcc gatgacaatt ctctagaaac ttttacatct 28740 cccaccacac ccgacgaaaa aaacatccca gattcaatga ttgcaattgt tgcagcggtg 28800

gcagtggtga tggcactaat aataatatgc atgcttttat atgcttgtcg ctacaaaaag 28860 Page 271

Sequence_Listing.txt tttcatccta aaaaacaaga tctcctacta aggcttaaca tttaatttct ttttatacag 28920

ccatggtttc cactaccaca ttccttatgc ttactagtct tgcaactctg acttctgctc 28980 gctcacacct cactgtaact ataggctcaa actgcacact aaaaggacct caaggtggtc 29040

atgtcttttg gtggagaata tatgacaatg gatggtttac aaaaccatgt gaccaacctg 29100 gtagattttt ctgcaacggc agagacctaa ccattatcaa cgtgacagca aatgacaaag 29160 gcttctatta tggaaccgac tataaaagta gtttagatta taacattatt gtactgccat 29220

ctaccactcc agcaccccgc acaactactt tctctagcag cagtgtcgct aacaatacaa 29280 tttccaatcc aacctttgcc gcgcttttaa aacgcactgt gaataattct acaacttcac 29340 atacaacaat ttccacttca acaatcagca ttatcgctgc agtgacaatt ggaatatcta 29400

ttcttgtttt taccataacc tactacgcct gctgctatag aaaagacaaa cataaaggtg 29460 atccattact tagatttgat atttaatttg ttcttttttt ttttatttac agtatggtga 29520 acaccaatca tggtacctag aaatttcttc ttcaccatac tcatttgtgc atttaatgtt 29580

tgcgctactt tcacagcagt agccacagca accccagact gtataggagc atttgcttcc 29640 tatgcacttt ttgcttttgt tacttgcatc tgcgtatgta gcatagtctg cctggttatt 29700

aattttttcc aacttctaga ctggatcctt gtgcgaattg cctacctgcg ccaccatccc 29760

gaataccgca accaaaatat cgcggcactt cttagactca tctaaaacca tgcaggctat 29820

actaccaata tttttgcttc tattgcttcc ctacgctgtc tcaaccccag ctgcctatag 29880

tactccacca gaacacctta gaaaatgcaa attccaacaa ccgtggtcat ttcttgcttg 29940 ctatcgagaa aaatcagaaa ttcccccaaa tttaataatg attgctggaa taattaatat 30000

aatctgttgc accataattt catttttgat atacccccta tttgattttg gctggaatgc 30060

tcccaatgca catgatcatc cacaagaccc agaggaacac attcccctac aaaacatgca 30120 acatccaata gcgctaatag attacgaaag tgaaccacaa cccccactac tccctgctat 30180

tagttacttc aacctaaccg gcggagatga ctgaaacact caccacctcc aattccgccg 30240 aggatctgct cgatatggac ggccgcgtct cagaacagcg acttgcccaa ctacgcatcc 30300 gccagcagca ggaacgcgcg gccaaagagc tcagagatgt catccaaatt caccaatgca 30360

aaaaaggcat attctgtttg gtaaaacaag ccaagatatc ctacgagatc accgctactg 30420 accatcgcct ctcttacgaa cttggccccc aacgacaaaa atttacctgc atggtgggaa 30480 tcaaccccat agttatcacc cagcaaagtg gagatactaa gggttgcatt cactgctcct 30540

gcgattccat cgagtgcacc tacaccctgc tgaagaccct atgcggccta agagacctgc 30600 taccaatgaa tggaagcgga gctactaact tcagcctgct gaagcaggct ggtgacgtcg 30660

aggagaatcc tggcccaatg gtgagcaaag gcgaagagct gttcaccggc gtggtgccca 30720 tcctggtgga gctggacggc gacgtgaacg gccacaagtt cagcgtgagc ggcgagggcg 30780 agggcgacgc cacctacggc aagctgaccc tgaagctgct gtgcaccacc ggcaagctgc 30840

ccgtgccctg gcccaccctg gtgaccaccc tgggctacgg cgtgcagtgc ttcgcccggt 30900 Page 272

Sequence_Listing.txt accccgacca catgaagcag cacgacttct tcaagagcgc catgcccgag ggctacgtgc 30960

aggagcggac catcttcttc aaggacgacg gcaactacaa gacccgggcc gaggtgaagt 31020 tcgagggcga caccctggtg aaccggatcg agctgaaggg catcgacttc aaggaggacg 31080

gcaacatcct gggccacaag ctggagtaca actacaacag ccacaacgtg tacatcaccg 31140 ccgacaagca gaagaacggc atcaaggcca acttcaagat ccggcacaac atcgaggacg 31200 gcggcgtgca gctggccgac cactaccagc agaacacccc catcggcgac ggccccgtgc 31260

tgctgcccga caaccactac ctgagctacc agagcgccct gttcaaggac cccaacgaga 31320 agcgggacca catggtgctg ctggagttcc tgaccgccgc cggcatcacc gagggcatga 31380 acgagctcta taagtaaaaa atgattaata aaaaatcact tacttgaaat cagcaataag 31440

gtctctgttg aaattttctc ccagcagcac ctcacttccc tcttcccaac tctggtattc 31500 taaaccccgt tcagcggcat actttctcca tactttaaag gggatgtcaa attttagctc 31560 ctctcctgta cccacaatct tcatgtcttt cttcccagat gaccaagaga gtccggctca 31620

gtgactcctt caaccctgtc tacccctatg aagatgaaag cacctcccaa caccccttta 31680 taaacccagg gtttatttcc ccaaatggct tcacacaaag cccagacgga gttcttactt 31740

taaaatgttt aaccccacta acaaccacag gcggatctct acagctaaaa gtgggagggg 31800

gacttacagt ggatgacact gatggtacct tacaagaaaa catacgtgct acagcaccca 31860

ttactaaaaa taatcactct gtagaactat ccattggaaa tggattagaa actcaaaaca 31920

ataaactatg tgccaaattg ggaaatgggt taaaatttaa caacggtgac atttgtataa 31980 aggatagtat taacacctta tggactggaa taaaccctcc acctaactgt caaattgtgg 32040

aaaacactaa tacaaatgat ggcaaactta ctttagtatt agtaaaaaac ggagggcttg 32100

ttaatggcta cgtgtctcta gttggtgtat cagacactgt gaaccaaatg ttcacacaaa 32160 agacagcaaa catccaatta agattatatt ttgactcttc tggaaatcta ttaactgatg 32220

aatcagactt aaaaattcca cttaaaaata aatcttctac agcgaccagt gaaactgtag 32280 ccagcagcaa agcctttatg ccaagtacta cagcttatcc cttcaacacc actactaggg 32340 atagtgaaaa ctacattcat ggaatatgtt actacatgac tagttatgat agaagtctat 32400

ttcccttgaa catttctata atgctaaaca gccgtatgat ttcttccaat gttgcctatg 32460 ccatacaatt tgaatggaat ctaaatgcaa gtgaatctcc agaaagcaac atagctacgc 32520 tgaccacatc cccctttttc ttttcttaca ttacagaaga cgacaactaa aataaagttt 32580

aagtgttttt atttaaaact cacaaaattc gagtagttat tttgcctcca ccttcccatt 32640 tgacagaata caccaatctc tccccacgca cagctttaaa catttggata ccattagaga 32700

tagacattgt tttagattcc acattccaaa cagtttcaga gcgagccaat ctggggtcag 32760 tgatagataa aaatccatcg cgatagtctt ttaaagcgct ttcacagtcc aactgctgcg 32820 gatgcgaatc cggagtctgg atcacggtca tctggaagaa gaacgatggg aatcataatc 32880

cgaaaacggt atcggacgat tgtgtctcat caaacccaca agcagccgct gtctgcgtcg 32940 Page 273

Sequence_Listing.txt ctccgtgcaa ctgctgttta tgggatcagg gtccacagtg tcctgaagca tgattttaat 33000

agcccttaac atcaactttc tggtgcgatg cgcgcagcaa cgcattctga tttcactcaa 33060 atctttgcag taggtacaac acattattac aatattgttt aataaaccat aattaaaagc 33120

gctccagcca aaactcatat ctgatataat cgcccctgca tgaccatcat accaaagttt 33180 aatataaatt aaatgacgtt ccctcaaaaa cacactaccc acatacatga tctcttttgg 33240 catgtgcata ttaacaatct gtctgtacca tggacaacgt tggttaatca tgcaacccaa 33300

tataaccttc cggaaccaca ctgccaacac cgctccccca gccatgcatt gaagtgaacc 33360 ctgctgatta caatgacaat gaagaaccca attctctcga ccgtgaatca cttgagaatg 33420 aaaaatatct atagtggcac aacatagaca taaatgcatg catcttctca taatttttaa 33480

ctcctcagga tttagaaaca tatcccaggg aataggaagc tcttgcagaa cagtaaagct 33540 ggcagaacaa ggaagaccac gaacacaact tacactatgc atagtcatag tatcacaatc 33600 tggcaacagc gggtggtctt cagtcataga agctcgggtt tcattttcct cacaacgtgg 33660

taactgggct ctggtgtaag ggtgatgtct ggcgcatgat gtcgagcgtg cgcgcaacct 33720 tgtcataatg gagttgcttc ctgacattct cgtattttgt atagcaaaac gcggccctgg 33780

cagaacacac tcttcttcgc cttctatcct gccgcttagc gtgttccgtg tgatagttca 33840

agtacagcca cactcttaag ttggtcaaaa gaatgctggc ttcagttgta atcaaaactc 33900

catcgcatct aattgttctg aggaaatcat ccacggtagc atatgcaaat cccaaccaag 33960

caatgcaact ggattgcgtt tcaagcagga gaggagaggg aagagacgga agaaccatgt 34020 taatttttat tccaaacgat ctcgcagtac ttcaaattgt agatcgcgca gatggcatct 34080

ctcgccccca ctgtgttggt gaaaaagcac agctaaatca aaagaaatgc gattttcaag 34140

gtgctcaacg gtggcttcca acaaagcctc cacgcgcaca tccaagaaca aaagaatacc 34200 aaaagaagga gcattttcta actcctcaat catcatatta cattcctgca ccattcccag 34260

ataattttca gctttccagc cttgaattat tcgtgtcagt tcttgtggta aatccaatcc 34320 acacattaca aacaggtccc ggagggcgcc ctccaccacc attcttaaac acaccctcat 34380 aatgacaaaa tatcttgctc ctgtgtcacc tgtagcgaat tgagaatggc aacatcaatt 34440

gacatgccct tggctctaag ttcttcttta agttctagtt gtaaaaactc tctcatatta 34500 tcaccaaact gcttagccag aagccccccg ggaacaagag caggggacgc tacagtgcag 34560 tacaagcgca gacctcccca attggctcca gcaaaaacaa gattggaata agcatattgg 34620

gaaccgccag taatatcatc gaagttgctg gaaatataat caggcagagt ttcttgtaaa 34680 aattgaataa aagaaaaatt tgccaaaaaa acattcaaaa cctctgggat gcaaatgcaa 34740

taggttaccg cgctgcgctc caacattgtt agttttgaat tagtctgcaa aaataaaaaa 34800 aaaaacaagc gtcatatcat agtagcctga cgaacaggtg gataaatcag tctttccatc 34860 acaagacaag ccacagggtc tccagctcga ccctcgtaaa acctgtcatg gtgattaaac 34920

aacagcaccg aaagttcctc gcggtgacca gcatgaataa ttcttgatga agcatacaat 34980 Page 274

Sequence_Listing.txt ccagacatgt tagcatcagt taacgagaaa aaacagccaa catagccttt gggtataatt 35040

atgcttaatc gtaagtatag caaagccacc cctcgcggat acaaagtaaa aggcacagga 35100 gaataaaaaa tataattatt tctctgctgc tgttcaggca acgtcgcccc cggtccctct 35160

aaatacacat acaaagcctc atcagccatg gcttaccaga caaagtacag cgggcacgca 35220 caagctctaa agtcactctc caacctctcc acaatatata tacacaagcc ctaaactgac 35280 gtaatgggag taaagtgtaa aaaatcccgc caaacccaac acacaccccg aaactgcgtc 35340

accagggaaa agtacagttt cacttccgca atcccaacaa gcgtcacttc ctctttctca 35400 cggtacgtca catcccatta acttgcaacg tcattttccc acggccgcgc cgccccgttt 35460 agccgttaac cccacagcca atcaccacac accccacaat ttttaaaatc acctcattta 35520

catattggca ccattccatc tataaggtat attattgatg atg 35563

Page 275

Claims (35)

THE CLAIMS DEFINING THE INVENTION ARE AS FOLLOWS

1. A recombinant adenovirus genome, comprising a heterologous open reading frame (ORF) and a self-cleaving peptide coding sequence, both operably linked to and in the same reading frame as an endogenous adenovirus ORF, wherein the self-cleaving peptide coding sequence is located between the heterologous ORF and the endogenous ORF, and wherein: the endogenous ORF is E1B-55k and the heterologous ORF is 3' of E1B-55k; the endogenous ORF is DNA polymerase and the heterologous ORF is 5' of DNA polymerase; the endogenous ORF is DNA-binding protein (DBP) and the heterologous ORF is 3' of DBP; the endogenous ORF is adenovirus death protein (ADP) and the heterologous ORF is 5' of ADP; the endogenous ORF is E3-14.7k and the heterologous ORF is 3'of E3-14.7k; the endogenous ORF is E4-ORF2 and the heterologous ORF is 5' of E4-ORF2; or the endogenous ORF is fiber and the heterologous ORF is 3' of fiber, wherein the heterologous ORF encodes a therapeutic protein or a fluorescent protein.

2. The recombinant adenovirus genome of claim 1, wherein the self-cleaving peptide is a 2A peptide or variant thereof.

3. The recombinant adenovirus genome of claim 2, wherein the 2A peptide comprises a porcine teschovirus-1 (PTV1) 2A (P2A) peptide, a foot and mouth disease virus (FMDV) 2A (F2A) peptide, an equine rhinitis A virus (ERAV) 2A (E2A) peptide or a Thosea asigna virus (TaV) 2A (T2A) peptide, or a variant thereof.

4. The recombinant adenovirus genome of claim 3, wherein the 2A peptides is a modified 2A peptide comprising Gly-Ser-Gly at the N-terminus.

5. The recombinant adenovirus genome of claim 3, wherein the amino acid sequence of the self-cleaving peptide is at least 80%, at least 85%, at least 90% or at least 95% identical to the amino acid sequence of any one of SEQ ID NOs: 14-21.

6. The recombinant adenovirus genome of claim 3, wherein the self-cleaving peptide comprises the amino acid sequence of any one of SEQ ID NOs: 14-21.

7. The recombinant adenovirus genome of any one of claims 1-6, wherein the heterologous ORF encodes a therapeutic protein, and wherein the therapeutic protein comprises an immunomodulator.

8. The recombinant adenovirus genome of any one of claims 1-6, wherein the heterologous ORF encodes a fluorescent protein.

9. The recombinant adenovirus genome of claim 8, wherein the fluorescent protein is a green fluorescent protein (GFP), a yellow fluorescent protein (YFP), a red fluorescent protein (RFP), or a blue fluorescent protein (BFP).

10. The recombinant adenovirus genome of claim 9, wherein the YFP is YPet or the RFP is mCherry.

11. The recombinant adenovirus genome of claim 8, comprising in the 5' to 3' direction: ElB-55K-P2A-YPet; ElB-55K-P2A-mCherry; YPet-P2A-(DNA polymerase); DBP-P2A-YPet; YPet-P2A-ADP; E3-14.7k-P2A-YPet; YPet-P2A-E4-ORF2; or mCherry- P2A-E4-ORF2.

12. The recombinant adenovirus genome of claim 11, comprising in the 5' to 3': E1B-55K-P2A-YPet sequence of adenovirus CMBT-456, wherein adenovirus CMBT 456 has a genome of SEQ ID NO: 3; EIB-55K-P2A-mCherry sequence of adenovirus CMBT-499, wherein adenovirus CMBT-499 has a genome of SEQ ID NO: 4;

YPet-P2A-DNA polymerase sequence of adenovirus CMBT-530, wherein adenovirus CMBT-530 has a genome of SEQ ID NO: 5; DBP-P2A-YPet sequence of adenovirus CMBT-886, wherein adenovirus CMBT-886 has a genome of SEQ ID NO: 6; YPet-P2A-ADP sequence of adenovirus CMBT-403, wherein adenovirus CMBT-403 has a genome of SEQ ID NO: 7; E3-14.7k-P2A-YPet sequence of adenovirus PCMN-887, wherein adenovirus PCMN 887 has a genome of SEQ ID NO: 9; YPet-P2A-E4-ORF2 sequence of adenovirus CMBT-457, wherein adenovirus CMBT 457 has a genome of SEQ ID NO: 10; mCherry- P2A-E4-ORF2 sequence of adenovirus CMBT-633, wherein adenovirus CMBT-633 has a genome of SEQ ID NO: 11; or E3-14.7k-P2A-YPet sequence of adenovirus PCMN-889, wherein adenovirus PCMN 889 has a genome of SEQ ID NO: 23.

13. The recombinant adenovirus genome of any one of claims 1-12, wherein the genome codes for a chimeric fiber protein comprising a fiber shaft from Ad5 and a fiber knob from a second serotype of adenovirus.

14. The recombinant adenovirus genome of claim 13, wherein the second serotype of adenovirus is Ad9 or Ad34.

15. The recombinant adenovirus genome of any one of claims 1-14, whereinthe E4orf6/7 protein coding sequence is deleted.

16. The recombinant adenovirus genome of any one of claims 1-15, whereinthe recombinant adenovirus genome is an Ad5 genome.

17. The recombinant adenovirus genome of any one of claims 1-16, wherein the recombinant adenovirus is an oncolytic adenovirus that exhibits replication defects and/or is replication deficient in a non-tumor cell as compared to a tumor cell.

18. The recombinant adenovirus genome of claim 17, whereinthe recombinant adenovirus genome comprises in the 5' to 3' direction YPet-P2A-ADP.

19. The recombinant adenovirus genome of claim 17 or claim 18, wherein the genome codes for a chimeric fiber protein comprising a fiber shaft from Ad5 and a fiber knob from Ad9 or Ad34, and wherein the E4orf6/7 protein coding sequence is deleted.

20. The recombinant adenovirus genome of claim 18 or claim 19, wherein the recombinant adenovirus genome comprises the YPet-P2A-ADP sequence of adenovirus CMBT-403, wherein adenovirus CMBT-403 has a genome of SEQ ID NO: 7.

21. The recombinant adenovirus genome of any one of claims 1-20, wherein the recombinant adenovirus genome is a chimeric adenovirus genome.

22. The recombinant adenovirus genome of claim 21, wherein the recombinant adenovirus genome is a capsid-swapped adenovirus genome having capsid proteins derived from Ad34 and the remaining proteins derived from Ad5.

23. A recombinant adenovirus comprising the recombinant adenovirus genome of any one of claims 1-22.

24. The recombinant adenovirus of claim 23, wherein the recombinant adenovirus is an oncolytic adenovirus that exhibits replication defects and/or is replication deficient in a non-tumor cell as compared to a tumor cell.

25. A composition comprising the recombinant adenovirus genome of any one of claims 1 22, or the recombinant adenovirus of claim 23 or claim 24, and a pharmaceutically acceptable carrier.

26. A method of delivering a therapeutic protein or a fluorescent protein to a subject, comprising administering to the subject the recombinant adenovirus genome of any one of claims 1-22, the recombinant adenovirus of claim 23 or claim 24, or the composition of claim 25.

27. A method of inhibiting tumor cell viability and/or tumor cell growth, comprising contacting the tumor cell with the recombinant adenovirus genome of any one of claims 1-22, the recombinant adenovirus of claim 23 or claim 24, or the composition of claim 25.

28. The method of claim 27, wherein the method is an in vitro method.

29. The method of claim 27, wherein the method is an in vivo method and contacting the tumor cell comprises administering the recombinant adenovirus genome, recombinant adenovirus, or composition to a subject with a tumor.

30. A method of inhibiting tumor progression or reducing tumor volume in a subject, comprising administering to the subject a therapeutically effective amount of the recombinant adenovirus genome of any one of claims 1-22, the recombinant adenovirus of claim 23 or claim 24, or the composition of claim 25, thereby inhibiting tumor progression or reducing tumor volume in the subject.

31. A method of treating cancer in a subject, comprising administering to the subject a therapeutically effective amount of the recombinant adenovirus genome of any one of claims 1-22, the recombinant adenovirus of claim 23 or claim 24, or the composition of claim 25, thereby treating cancer in the subject.

32. The method of any one of claims 29-31, further comprising administering an additional therapeutic agent to the subject.

33. Use of the recombinant adenovirus genome of any one of claims 1-22, the recombinant adenovirus of claim 23 or claim 24, or the composition of claim 25, in the preparation of a medicament for inhibiting tumor cell viability and/or tumor cell growth in a subject.

34. Use of the recombinant adenovirus genome of any one of claims 1-22, the recombinant adenovirus of claim 23 or claim 24, or the composition of claim 25, in the preparation of a medicament for inhibiting tumor progression or reducing tumor volume in a subject.

35. Use of the recombinant adenovirus genome of any one of claims 1-22, the recombinant adenovirus of claim 23 or claim 24, or the composition of claim 25, in the preparation of a medicament for treating cancer in a subject.