Deprecated: The each() function is deprecated. This message will be suppressed on further calls in /home/zhenxiangba/zhenxiangba.com/public_html/phproxy-improved-master/index.php on line 456
AU513579B2 - 11b-amino-alkanoyloxy or aralkanoyloxy pregnenes and androstanes - Google Patents
[go: Go Back, main page]

AU513579B2 - 11b-amino-alkanoyloxy or aralkanoyloxy pregnenes and androstanes - Google Patents

11b-amino-alkanoyloxy or aralkanoyloxy pregnenes and androstanes

Info

Publication number
AU513579B2
AU513579B2 AU21065/77A AU2106577A AU513579B2 AU 513579 B2 AU513579 B2 AU 513579B2 AU 21065/77 A AU21065/77 A AU 21065/77A AU 2106577 A AU2106577 A AU 2106577A AU 513579 B2 AU513579 B2 AU 513579B2
Authority
AU
Australia
Prior art keywords
aralkanoyloxy
pregnenes
androstanes
alkanoyloxy
amino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
AU21065/77A
Other versions
AU2106577A (en
Inventor
G. H. May P. J. and Ayres BE Phillipps
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Laboratories Ltd
Original Assignee
Glaxo Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Laboratories Ltd filed Critical Glaxo Laboratories Ltd
Publication of AU2106577A publication Critical patent/AU2106577A/en
Application granted granted Critical
Publication of AU513579B2 publication Critical patent/AU513579B2/en
Expired legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J43/00Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00Anaesthetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00Anaesthetics
    • A61P23/02Local anaesthetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/02Drugs for disorders of the nervous system for peripheral neuropathies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J13/00Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17
    • C07J13/005Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17 with double bond in position 16 (17)
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J17/00Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J3/00Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
    • C07J3/005Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom the carbon atom being part of a carboxylic function
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J31/00Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J41/00Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0088Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing unsubstituted amino radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J41/00Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0094Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing nitrile radicals, including thiocyanide radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J5/00Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0007Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond not substituted in position 17 alfa
    • C07J5/0015Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond not substituted in position 17 alfa not substituted in position 16
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J63/00Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
    • C07J63/008Expansion of ring D by one atom, e.g. D homo steroids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J7/00Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/0005Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
    • C07J7/001Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group
    • C07J7/0015Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group not substituted in position 17 alfa
    • C07J7/0025Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group not substituted in position 17 alfa substituted in position 16
    • C07J7/003Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group not substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J71/00Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005Oxygen-containing hetero ring
    • C07J71/001Oxiranes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Anesthesiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Toxicology (AREA)
  • Neurology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AU21065/77A 1976-01-06 1977-01-05 11b-amino-alkanoyloxy or aralkanoyloxy pregnenes and androstanes Expired AU513579B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB357/76A GB1570394A (en) 1976-01-06 1976-01-06 11-acyloxy-3-hydroxy steroids
GBGB357/76 1976-01-06

Publications (2)

Publication Number Publication Date
AU2106577A AU2106577A (en) 1978-07-13
AU513579B2 true AU513579B2 (en) 1980-12-11

Family

ID=9702974

Family Applications (1)

Application Number Title Priority Date Filing Date
AU21065/77A Expired AU513579B2 (en) 1976-01-06 1977-01-05 11b-amino-alkanoyloxy or aralkanoyloxy pregnenes and androstanes

Country Status (12)

Country Link
JP (1) JPS5285159A (en)
AU (1) AU513579B2 (en)
BE (1) BE850108A (en)
CA (1) CA1084903A (en)
DE (1) DE2700267A1 (en)
DK (1) DK3577A (en)
FR (1) FR2361419A1 (en)
GB (1) GB1570394A (en)
NL (1) NL7700054A (en)
NZ (1) NZ183004A (en)
SE (1) SE7700098L (en)
ZA (1) ZA7759B (en)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ300694A3 (en) * 1993-12-02 1996-05-15 Akzo Nobel Nv Substituted 2beta-morpholinandrostane derivatives, process of their preparation, their use for preparing pharmaceutical preparations and pharmaceutical compositions containing thereof
GB0105772D0 (en) * 2001-03-08 2001-04-25 Sterix Ltd Use
EP3572417B1 (en) 2011-10-14 2025-12-17 Sage Therapeutics, LLC 3,3 disubstituted 19-nor pregnane compounds, compositions, and uses thereof
EP2806877B2 (en) 2012-01-23 2025-01-29 Sage Therapeutics, Inc. Neuroactive steroid formulations comprising a complex of allopregnanolone and sulfobutyl ether beta-cyclodextrin
CA2882708A1 (en) 2012-08-21 2014-02-27 Sage Therapeutics, Inc. Methods of treating epilepsy or status epilepticus
KR102396328B1 (en) 2013-04-17 2022-05-10 세이지 테라퓨틱스, 인크. 19-nor c3,3-disubstituted c21-n-pyrazolyl steroids and methods of use thereof
US9725481B2 (en) 2013-04-17 2017-08-08 Sage Therapeutics, Inc. 19-nor C3, 3-disubstituted C21-C-bound heteroaryl steroids and methods of use thereof
EP2986624B1 (en) 2013-04-17 2020-03-25 Sage Therapeutics, Inc. 19-nor neuroactive steroids for methods of treatment
US20160068563A1 (en) 2013-04-17 2016-03-10 Boyd L. Harrison 19-nor neuroactive steroids and methods of use thereof
SI3021852T1 (en) * 2013-07-19 2021-07-30 Sage Therapeutics, Inc. Neuroactive steroids, compositions, and uses thereof
AU2014308621C1 (en) 2013-08-23 2022-01-06 Sage Therapeutics, Inc. Neuroactive steroids, compositions, and uses thereof
US10246482B2 (en) 2014-06-18 2019-04-02 Sage Therapeutics, Inc. Neuroactive steroids, compositions, and uses thereof
JOP20200195A1 (en) 2014-09-08 2017-06-16 Sage Therapeutics Inc Neuroactive steroids and formulations, and their uses
CN117024501A (en) 2014-10-16 2023-11-10 萨奇治疗股份有限公司 Compositions and methods targeting CNS disorders
ME03809B (en) 2014-10-16 2021-04-20 Sage Therapeutics Inc COMPOSITIONS AND METHODS OF TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS
WO2016082789A1 (en) 2014-11-27 2016-06-02 Sage Therapeutics, Inc. Compositions and methods for treating cns disorders
RS61530B1 (en) 2015-01-26 2021-04-29 Sage Therapeutics Inc Compositions and methods for treating cns disorders
EP4155314A1 (en) 2015-02-20 2023-03-29 Sage Therapeutics, Inc. Neuroactive steroids, compositions, and uses thereof
WO2016201092A1 (en) 2015-06-10 2016-12-15 Boston Scientific Scimed, Inc. Bodily substance detection by evaluating photoluminescent response to excitation radiation
KR20240157128A (en) 2016-03-08 2024-10-31 세이지 테라퓨틱스, 인크. Neuroactive steroids, compositions, and uses thereof
WO2018013615A1 (en) 2016-07-11 2018-01-18 Sage Therapeutics, Inc. C7, c12, and c16 substituted neuroactive steroids and their methods of use
MA45599A (en) 2016-07-11 2019-05-15 Sage Therapeutics Inc NEUROACTIVE STEROIDS SUBSTITUTED FOR C17, C20 AND C21 AND THEIR USE PROCEDURES
BR112020012761A2 (en) * 2017-12-22 2021-02-17 Sage Therapeutics, Inc. compositions and methods for the treatment of snc disorders
KR20250174100A (en) 2018-12-05 2025-12-11 세이지 테라퓨틱스, 인크. Neuroactive steroids and their methods of use
SG11202112391UA (en) 2019-05-31 2021-12-30 Sage Therapeutics Inc Neuroactive steroids and compositions thereof
JP7754725B2 (en) * 2019-06-27 2025-10-15 セージ セラピューティクス, インコーポレイテッド Compositions and methods for treating CNS disorders
CA3143509A1 (en) 2019-06-27 2020-12-30 Sage Therapeutics, Inc. Compositions and methods for treating cns disorders
CN114729000A (en) * 2019-06-27 2022-07-08 萨奇治疗股份有限公司 Compounds for the treatment of CNS disorders

Also Published As

Publication number Publication date
FR2361419B1 (en) 1980-04-04
NZ183004A (en) 1980-03-05
SE7700098L (en) 1977-07-07
DK3577A (en) 1977-07-07
BE850108A (en) 1977-07-05
FR2361419A1 (en) 1978-03-10
GB1570394A (en) 1980-07-02
NL7700054A (en) 1977-07-08
AU2106577A (en) 1978-07-13
ZA7759B (en) 1978-02-22
CA1084903A (en) 1980-09-02
DE2700267A1 (en) 1977-07-14
JPS5285159A (en) 1977-07-15

Similar Documents

Publication Publication Date Title
AU513579B2 (en) 11b-amino-alkanoyloxy or aralkanoyloxy pregnenes and androstanes
AU527944B2 (en) Bag clip and manufacture
AU501715B2 (en) Reinforcement joint
AU514849B2 (en) Composition and process
AU513665B2 (en) Lidocaine antigens and antibodies
AU501685B2 (en) D-homo-20-keto pregnanes
AU511157B2 (en) Clip
AU513232B2 (en) Goods-transport vehicle
AU2957277A (en) Antiinflammatory steroids
AU496163B2 (en) Composite pipeline
SU694609A1 (en) Reinforcement and form assembly
AU2545777A (en) Tailgate
JPS5322216A (en) Dredging and dehydrating vehicle
AU503505B2 (en) 13-ethynyl and 13-halovinyl steroids
AU2136277A (en) Imidazothiazoles and thiazolopyrmideines
SU676804A1 (en) Pipeline connection
AU497882B2 (en) B-phenyl-4-piperidinores and dihydropyridinones
AU3469178A (en) 19-nor pregnatetraenes
AU2888377A (en) Borosilicate and germania-silicate material
AU2711477A (en) Construction bracket
AU499237B2 (en) Aminomethyl-methoxy-penams and cephems
AU510187B2 (en) Steroid intermediates
AU517326B2 (en) 7-HALO-3, 20-DIOXO-l, 4-PREGNADIENES AND 4 PREGNENES AND THEIR PREPARATION
AU482216B2 (en) Composition and process
AU513176B2 (en) Combined document and envelope