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AU569072B2 - Ultrasound contrasting agent containing microparticles and gas micro bubbles - Google Patents
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AU569072B2 - Ultrasound contrasting agent containing microparticles and gas micro bubbles - Google Patents

Ultrasound contrasting agent containing microparticles and gas micro bubbles

Info

Publication number
AU569072B2
AU569072B2 AU26806/84A AU2680684A AU569072B2 AU 569072 B2 AU569072 B2 AU 569072B2 AU 26806/84 A AU26806/84 A AU 26806/84A AU 2680684 A AU2680684 A AU 2680684A AU 569072 B2 AU569072 B2 AU 569072B2
Authority
AU
Australia
Prior art keywords
agent containing
containing microparticles
micro bubbles
contrasting agent
gas micro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU26806/84A
Other versions
AU2680684A (en
Inventor
Jurgen Hilmann
Lothar Lange
Ingfried Zimmermann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering AG filed Critical Schering AG
Publication of AU2680684A publication Critical patent/AU2680684A/en
Application granted granted Critical
Publication of AU569072B2 publication Critical patent/AU569072B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasonic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasonic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/22—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for
    • A61B2017/22082—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for after introduction of a substance
    • A61B2017/22089—Gas-bubbles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/39—Markers, e.g. radio-opaque or breast lesions markers
    • A61B2090/3925—Markers, e.g. radio-opaque or breast lesions markers ultrasonic

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Acoustics & Sound (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Cosmetics (AREA)
  • Investigating Or Analyzing Materials By The Use Of Ultrasonic Waves (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

1. Contrast medium containing microparticles and gas bubbles for ultrasound diagnostics, characterised in that it contains microparticles of a mixture of a semi-solid or liquid surface-active substance and a non-surface-active solid in a liquid carrier.
AU26806/84A 1983-04-15 1984-04-13 Ultrasound contrasting agent containing microparticles and gas micro bubbles Ceased AU569072B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3313947 1983-04-15
DE3313947A DE3313947A1 (en) 1983-04-15 1983-04-15 MICROPARTICLES AND GAS BUBBLES CONTAINING ULTRASONIC CONTRASTING AGENTS

Publications (2)

Publication Number Publication Date
AU2680684A AU2680684A (en) 1984-10-18
AU569072B2 true AU569072B2 (en) 1988-01-21

Family

ID=6196666

Family Applications (1)

Application Number Title Priority Date Filing Date
AU26806/84A Ceased AU569072B2 (en) 1983-04-15 1984-04-13 Ultrasound contrasting agent containing microparticles and gas micro bubbles

Country Status (12)

Country Link
EP (1) EP0123235B1 (en)
JP (1) JPS59205329A (en)
AT (1) ATE36959T1 (en)
AU (1) AU569072B2 (en)
CA (1) CA1232837A (en)
DE (2) DE3313947A1 (en)
DK (1) DK165622C (en)
FI (1) FI81265C (en)
IE (1) IE57197B1 (en)
NO (1) NO163669C (en)
NZ (1) NZ207854A (en)
ZA (1) ZA842800B (en)

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DE3834705A1 (en) * 1988-10-07 1990-04-12 Schering Ag ULTRASONIC CONTRASTING AGENTS FROM GAS BUBBLES AND MICROPARTICLES CONTAINING FATTY ACID
US5141738A (en) * 1983-04-15 1992-08-25 Schering Aktiengesellschaft Ultrasonic contrast medium comprising gas bubbles and solid lipophilic surfactant-containing microparticles and use thereof
DE3529195A1 (en) * 1985-08-14 1987-02-26 Max Planck Gesellschaft CONTRAST AGENTS FOR ULTRASONIC EXAMINATIONS AND METHOD FOR THE PRODUCTION THEREOF
DE3637926C1 (en) * 1986-11-05 1987-11-26 Schering Ag Ultrasonic manometry in a liquid using microbubbles
DE3741199A1 (en) * 1987-12-02 1989-08-17 Schering Ag USE OF ULTRASONIC CONTRASTING AGENTS FOR ULTRASONIC LITHOTRIPSY
DE3741201A1 (en) * 1987-12-02 1989-06-15 Schering Ag ULTRASONIC PROCESS AND METHOD FOR IMPLEMENTING IT
US5425366A (en) * 1988-02-05 1995-06-20 Schering Aktiengesellschaft Ultrasonic contrast agents for color Doppler imaging
DE3803971C2 (en) * 1988-02-05 1997-09-18 Schering Ag Ultrasound contrast media
DE58908194D1 (en) * 1988-02-05 1994-09-22 Schering Ag ULTRASONIC CONTRAST AGENTS, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS DIAGNOSTICS AND THERAPEUTICS.
DE3803972A1 (en) * 1988-02-05 1989-08-10 Schering Ag ULTRASONIC CONTRASTING AGENTS
FR2643252B1 (en) * 1989-02-21 1991-06-07 Technomed Int Sa APPARATUS FOR THE SELECTIVE DESTRUCTION OF CELLS INCLUDING SOFT TISSUES AND BONES WITHIN THE BODY OF A LIVING BODY BY IMPLOSION OF GAS BUBBLES
USRE39146E1 (en) 1990-04-02 2006-06-27 Bracco International B.V. Long-lasting aqueous dispersions or suspensions of pressure-resistant gas-filled microvesicles and methods for the preparation thereof
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US6989141B2 (en) 1990-05-18 2006-01-24 Bracco International B.V. Ultrasound contrast agents and methods of making and using them
US6613306B1 (en) 1990-04-02 2003-09-02 Bracco International B.V. Ultrasound contrast agents and methods of making and using them
US7083778B2 (en) 1991-05-03 2006-08-01 Bracco International B.V. Ultrasound contrast agents and methods of making and using them
US5445813A (en) 1992-11-02 1995-08-29 Bracco International B.V. Stable microbubble suspensions as enhancement agents for ultrasound echography
US5578292A (en) 1991-11-20 1996-11-26 Bracco International B.V. Long-lasting aqueous dispersions or suspensions of pressure-resistant gas-filled microvesicles and methods for the preparation thereof
US5205287A (en) * 1990-04-26 1993-04-27 Hoechst Aktiengesellschaft Ultrasonic contrast agents, processes for their preparation and the use thereof as diagnostic and therapeutic agents
US5137928A (en) * 1990-04-26 1992-08-11 Hoechst Aktiengesellschaft Ultrasonic contrast agents, processes for their preparation and the use thereof as diagnostic and therapeutic agents
US5190982A (en) * 1990-04-26 1993-03-02 Hoechst Aktiengesellschaft Ultrasonic contrast agents, processes for their preparation and the use thereof as diagnostic and therapeutic agents
AU636481B2 (en) * 1990-05-18 1993-04-29 Bracco International B.V. Polymeric gas or air filled microballoons usable as suspensions in liquid carriers for ultrasonic echography
CA2068334C (en) * 1990-10-05 1996-09-03 Bracco International B.V. Method for the preparation of stable suspensions of hollow gas-filled microspheres suitable for ultrasonic echography
DK0586524T3 (en) † 1991-06-03 1997-05-20 Nycomed Imaging As
GB9200388D0 (en) * 1992-01-09 1992-02-26 Nycomed As Improvements in or relating to contrast agents
GB9200391D0 (en) * 1992-01-09 1992-02-26 Nycomed As Improvements in or relating to contrast agents
GB9200387D0 (en) * 1992-01-09 1992-02-26 Nycomed As Improvements in or relating to contrast agents
IL104084A (en) 1992-01-24 1996-09-12 Bracco Int Bv Long-lasting aqueous suspensions of pressure-resistant gas-filled microvesicles their preparation and contrast agents consisting of them
ES2068151B1 (en) 1993-06-23 1995-11-16 Cabrera Garrido Juan INJECTABLE MICROS FOAM FOR SCLEROSIS.
US5798091A (en) 1993-07-30 1998-08-25 Alliance Pharmaceutical Corp. Stabilized gas emulsion containing phospholipid for ultrasound contrast enhancement
DK0711179T3 (en) 1993-07-30 2005-02-14 Imcor Pharmaceutical Co Stabilized ultrasound microbubble compositions
PT682530E (en) * 1993-12-15 2003-06-30 Bracco Research Sa UTEIS GAS MIXTURES AS CONTRAST MEANS FOR ULTRASSONS
DE4406474A1 (en) * 1994-02-23 1995-08-24 Schering Ag Gas-containing microparticles, agents containing them, their use in ultrasound diagnostics, and methods for producing the particles and agents
US5540909A (en) * 1994-09-28 1996-07-30 Alliance Pharmaceutical Corp. Harmonic ultrasound imaging with microbubbles
DE19510690A1 (en) * 1995-03-14 1996-09-19 Schering Ag Polymeric nano- and / or microparticles, processes for their production, and use in medical diagnostics and therapy
US5804162A (en) * 1995-06-07 1998-09-08 Alliance Pharmaceutical Corp. Gas emulsions stabilized with fluorinated ethers having low Ostwald coefficients
DE19602930A1 (en) * 1996-01-18 1997-07-24 Schering Ag Porous matrices made of low molecular weight substances for the generation of stable gas bubble suspensions, their use as ultrasound contrast agents and processes for their production
DE19813174A1 (en) * 1998-03-25 1999-05-27 Schering Ag Gas-filled microparticles, used for administering biologically active substances
EP1140211A1 (en) 1998-10-12 2001-10-10 Mallinckrodt Inc. Novel ultrasound contrast agents
GB9912356D0 (en) 1999-05-26 1999-07-28 Btg Int Ltd Generation of microfoam
US7109167B2 (en) 2000-06-02 2006-09-19 Bracco International B.V. Compounds for targeting endothelial cells, compositions containing the same and methods for their use
US6962071B2 (en) 2001-04-06 2005-11-08 Bracco Research S.A. Method for improved measurement of local physical parameters in a fluid-filled cavity
US8512680B2 (en) 2001-08-08 2013-08-20 Btg International Ltd. Injectables in foam, new pharmaceutical applications
US7211240B2 (en) 2002-03-01 2007-05-01 Bracco International B.V. Multivalent constructs for therapeutic and diagnostic applications
US7261876B2 (en) 2002-03-01 2007-08-28 Bracco International Bv Multivalent constructs for therapeutic and diagnostic applications
AU2003278807A1 (en) 2002-03-01 2004-08-13 Bracco International B.V. Kdr and vegf/kdr binding peptides and their use in diagnosis and therapy
US8623822B2 (en) 2002-03-01 2014-01-07 Bracco Suisse Sa KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy
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EP0052575A2 (en) * 1980-11-17 1982-05-26 Schering Aktiengesellschaft Composition generating microbubbles
AU8916382A (en) * 1981-10-16 1983-04-21 Schering Aktiengesellschaft Contrast medium for ultrasonic diagnosis
AU2680584A (en) * 1983-04-15 1984-10-18 Schering Aktiengesellschaft Ultrasound contrast agent containing microparticles and gas micro-bubbles

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EP0052575A2 (en) * 1980-11-17 1982-05-26 Schering Aktiengesellschaft Composition generating microbubbles
AU8916382A (en) * 1981-10-16 1983-04-21 Schering Aktiengesellschaft Contrast medium for ultrasonic diagnosis
AU2680584A (en) * 1983-04-15 1984-10-18 Schering Aktiengesellschaft Ultrasound contrast agent containing microparticles and gas micro-bubbles

Also Published As

Publication number Publication date
DK79084D0 (en) 1984-02-20
DK79084A (en) 1984-10-16
EP0123235A2 (en) 1984-10-31
NO163669C (en) 1990-07-04
NO163669B (en) 1990-03-26
AU2680684A (en) 1984-10-18
FI81265B (en) 1990-06-29
EP0123235A3 (en) 1986-11-20
DE3473829D1 (en) 1988-10-13
DE3313947A1 (en) 1984-10-18
ATE36959T1 (en) 1988-09-15
IE57197B1 (en) 1992-06-03
NO841490L (en) 1984-10-16
IE840836L (en) 1984-10-15
FI81265C (en) 1990-10-10
NZ207854A (en) 1988-01-08
FI841463A0 (en) 1984-04-12
FI841463L (en) 1984-10-16
CA1232837A (en) 1988-02-16
JPH0417164B2 (en) 1992-03-25
DK165622B (en) 1992-12-28
DK165622C (en) 1993-06-01
EP0123235B1 (en) 1988-09-07
JPS59205329A (en) 1984-11-20
ZA842800B (en) 1984-11-28

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Legal Events

Date Code Title Description
MK14 Patent ceased section 143(a) (annual fees not paid) or expired