AU570724B2 - Preparation of compounds containing carboxamide groups - Google Patents
Preparation of compounds containing carboxamide groupsInfo
- Publication number
- AU570724B2 AU570724B2 AU33073/84A AU3307384A AU570724B2 AU 570724 B2 AU570724 B2 AU 570724B2 AU 33073/84 A AU33073/84 A AU 33073/84A AU 3307384 A AU3307384 A AU 3307384A AU 570724 B2 AU570724 B2 AU 570724B2
- Authority
- AU
- Australia
- Prior art keywords
- preparation
- reaction
- compounds containing
- compounds
- carboxamide groups
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- 125000005392 carboxamide group Chemical group NC(=O)* 0.000 title abstract 2
- 125000003277 amino group Chemical group 0.000 abstract 1
- 150000008064 anhydrides Chemical class 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 125000000524 functional group Chemical group 0.000 abstract 1
- GPRLSGONYQIRFK-UHFFFAOYSA-N hydron Chemical compound [H+] GPRLSGONYQIRFK-UHFFFAOYSA-N 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000011541 reaction mixture Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
- C07K5/0806—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
- C07K1/08—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using activating agents
- C07K1/082—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using activating agents containing phosphorus
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Analytical Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Peptides Or Proteins (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
1. A process for the preparation of compounds containing carboxamide groups by reaction of compounds which contain a carboxyl group, in the presence of dialkylphosphinic anhydrides, with compounds which contain a free amino group, which comprises maintaining the hydrogen ion concentration in the reaction mixture at an almost constant value in a range of 10**-5 to 10**-10 (mol/l) during the reaction and, after the reaction is complete, eliminating radicals which have, where appropriate, been introduced to protect other functional groups.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE3333456 | 1983-09-16 | ||
| DE19833333456 DE3333456A1 (en) | 1983-09-16 | 1983-09-16 | METHOD FOR PRODUCING COMPOUNDS CONTAINING CARBONIC ACID AMIDE, IN PARTICULAR PEPTIDES |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU3307384A AU3307384A (en) | 1985-03-21 |
| AU570724B2 true AU570724B2 (en) | 1988-03-24 |
Family
ID=6209237
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU33073/84A Expired AU570724B2 (en) | 1983-09-16 | 1984-09-14 | Preparation of compounds containing carboxamide groups |
Country Status (13)
| Country | Link |
|---|---|
| EP (1) | EP0135183B1 (en) |
| JP (1) | JPS6084249A (en) |
| AT (1) | ATE33251T1 (en) |
| AU (1) | AU570724B2 (en) |
| CA (1) | CA1285698C (en) |
| DE (2) | DE3333456A1 (en) |
| DK (1) | DK160041C (en) |
| ES (1) | ES535919A0 (en) |
| GR (1) | GR80370B (en) |
| HU (1) | HU189936B (en) |
| IE (1) | IE58082B1 (en) |
| IL (1) | IL72943A (en) |
| PT (1) | PT79195B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3333454A1 (en) * | 1983-09-16 | 1985-04-11 | Hoechst Ag, 6230 Frankfurt | METHOD FOR PRODUCING N-ALKYLATED DIPEPTIDES AND THEIR ESTERS |
| DE3333455A1 (en) * | 1983-09-16 | 1985-04-11 | Hoechst Ag, 6230 Frankfurt | METHOD FOR PRODUCING N-ALKYLATED DIPEPTIDES AND THEIR ESTERS |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU7955682A (en) * | 1981-01-17 | 1982-07-29 | Aventis Pharma Deutschland Gmbh | Prepare amides especially peptides |
| AU3307084A (en) * | 1983-09-16 | 1985-03-21 | Aventis Pharma Deutschland Gmbh | Preparation of n-alkylated dipeptides |
| AU3307184A (en) * | 1983-09-16 | 1985-03-21 | Aventis Pharma Deutschland Gmbh | Preparation of n-alkylated dipeptides |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2901843A1 (en) * | 1979-01-18 | 1980-07-31 | Hoechst Ag | METHOD FOR PRODUCING CARBONIC ACID AMIDES AND PEPTIDES |
-
1983
- 1983-09-16 DE DE19833333456 patent/DE3333456A1/en not_active Withdrawn
-
1984
- 1984-09-07 AT AT84110679T patent/ATE33251T1/en not_active IP Right Cessation
- 1984-09-07 EP EP84110679A patent/EP0135183B1/en not_active Expired
- 1984-09-07 DE DE8484110679T patent/DE3470162D1/en not_active Expired
- 1984-09-10 HU HU843418A patent/HU189936B/en unknown
- 1984-09-13 CA CA000463073A patent/CA1285698C/en not_active Expired - Lifetime
- 1984-09-13 PT PT79195A patent/PT79195B/en active IP Right Revival
- 1984-09-14 IL IL72943A patent/IL72943A/en not_active IP Right Cessation
- 1984-09-14 JP JP59191870A patent/JPS6084249A/en active Granted
- 1984-09-14 GR GR80370A patent/GR80370B/en unknown
- 1984-09-14 DK DK440184A patent/DK160041C/en not_active IP Right Cessation
- 1984-09-14 AU AU33073/84A patent/AU570724B2/en not_active Expired
- 1984-09-14 IE IE235284A patent/IE58082B1/en not_active IP Right Cessation
- 1984-09-14 ES ES535919A patent/ES535919A0/en active Granted
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU7955682A (en) * | 1981-01-17 | 1982-07-29 | Aventis Pharma Deutschland Gmbh | Prepare amides especially peptides |
| AU3307084A (en) * | 1983-09-16 | 1985-03-21 | Aventis Pharma Deutschland Gmbh | Preparation of n-alkylated dipeptides |
| AU3307184A (en) * | 1983-09-16 | 1985-03-21 | Aventis Pharma Deutschland Gmbh | Preparation of n-alkylated dipeptides |
Also Published As
| Publication number | Publication date |
|---|---|
| IE58082B1 (en) | 1993-06-30 |
| DK160041B (en) | 1991-01-21 |
| ES8505939A1 (en) | 1985-06-16 |
| CA1285698C (en) | 1991-07-02 |
| IL72943A (en) | 1988-07-31 |
| IE842352L (en) | 1985-03-16 |
| DE3333456A1 (en) | 1985-04-11 |
| ATE33251T1 (en) | 1988-04-15 |
| HU189936B (en) | 1986-08-28 |
| IL72943A0 (en) | 1984-12-31 |
| JPH0417177B2 (en) | 1992-03-25 |
| DK440184D0 (en) | 1984-09-14 |
| EP0135183A3 (en) | 1986-03-05 |
| DK440184A (en) | 1985-03-17 |
| GR80370B (en) | 1985-01-11 |
| EP0135183A2 (en) | 1985-03-27 |
| DE3470162D1 (en) | 1988-05-05 |
| HUT36083A (en) | 1985-08-28 |
| PT79195B (en) | 1986-09-10 |
| JPS6084249A (en) | 1985-05-13 |
| EP0135183B1 (en) | 1988-03-30 |
| DK160041C (en) | 1991-06-10 |
| PT79195A (en) | 1984-10-01 |
| AU3307384A (en) | 1985-03-21 |
| ES535919A0 (en) | 1985-06-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PC | Assignment registered |
Owner name: AVENTIS PHARMA DEUTSCHLAND GMBH Free format text: FORMER OWNER WAS: HOECHST A.G. |