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AU579196B2 - 4-Oxo-piridol(2,3-d)pyrimidine derivatives, process for their preparation and pharmaceutical compositions containing them - Google Patents
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AU579196B2 - 4-Oxo-piridol(2,3-d)pyrimidine derivatives, process for their preparation and pharmaceutical compositions containing them - Google Patents

4-Oxo-piridol(2,3-d)pyrimidine derivatives, process for their preparation and pharmaceutical compositions containing them

Info

Publication number
AU579196B2
AU579196B2 AU48857/85A AU4885785A AU579196B2 AU 579196 B2 AU579196 B2 AU 579196B2 AU 48857/85 A AU48857/85 A AU 48857/85A AU 4885785 A AU4885785 A AU 4885785A AU 579196 B2 AU579196 B2 AU 579196B2
Authority
AU
Australia
Prior art keywords
oxo
preparation
pyrimidine derivatives
piridol
pharmaceutical compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU48857/85A
Other versions
AU4885785A (en
Inventor
Edgar Dr. Fritschi
Johannes Dr. Hartenstein
Jurgen DR. Kleinschroth
Karl Dr. Mannhardt
Hartmut Dr. Osswald
Gerhard Dr. Satzinger
Gunter Dr. Weinheimer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Goedecke GmbH
Original Assignee
Goedecke GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Goedecke GmbH filed Critical Goedecke GmbH
Publication of AU4885785A publication Critical patent/AU4885785A/en
Application granted granted Critical
Publication of AU579196B2 publication Critical patent/AU579196B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

4-Oxo-pyrido[2,3-d]pyrimidine derivatives are herein described as well as processes for their preparation. These compounds possess valuable pharmacological properties. As calcium antagonists they exert vasospasmolytic, vasodilatory, and antihypertensive activities. Surprisingly some of the compounds also have the effect of increasing contractility. They are therefore particularly suited for the treatment of vascular diseases.
AU48857/85A 1984-10-19 1985-10-18 4-Oxo-piridol(2,3-d)pyrimidine derivatives, process for their preparation and pharmaceutical compositions containing them Ceased AU579196B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19843438350 DE3438350A1 (en) 1984-10-19 1984-10-19 4-OXO-PYRIDO (2,3-D) PYRIMIDINE DERIVATIVES, METHOD FOR THE PRODUCTION AND USE THEREOF
DE3438350 1984-10-19

Publications (2)

Publication Number Publication Date
AU4885785A AU4885785A (en) 1986-04-24
AU579196B2 true AU579196B2 (en) 1988-11-17

Family

ID=6248307

Family Applications (1)

Application Number Title Priority Date Filing Date
AU48857/85A Ceased AU579196B2 (en) 1984-10-19 1985-10-18 4-Oxo-piridol(2,3-d)pyrimidine derivatives, process for their preparation and pharmaceutical compositions containing them

Country Status (14)

Country Link
US (1) US4677108A (en)
EP (1) EP0180833B1 (en)
JP (1) JPS61100581A (en)
CN (1) CN85107634B (en)
AT (1) ATE44743T1 (en)
AU (1) AU579196B2 (en)
CA (1) CA1260936A (en)
DD (1) DD242406A5 (en)
DE (2) DE3438350A1 (en)
DK (1) DK478485A (en)
ES (1) ES8605518A1 (en)
GR (1) GR852525B (en)
HU (1) HU192728B (en)
ZA (1) ZA857990B (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3438351A1 (en) * 1984-10-19 1986-04-24 Gödecke AG, 1000 Berlin 4-ALKOXY-PYRIDO (2,3-D) PYRIMIDINE DERIVATIVES, METHOD FOR THE PRODUCTION AND USE THEREOF
DE3501696A1 (en) * 1985-01-19 1986-07-24 Bayer Ag, 5090 Leverkusen PYRIDOPYRIMIDINE, SEVERAL PROCESS FOR THEIR PRODUCTION AND THEIR USE AS MEDICINAL PRODUCT
IT1229118B (en) * 1988-07-29 1991-07-22 Simes ACTIVE COMPOUNDS ON THE CARDIOVASCULAR SYSTEM THAT PRESENT BOTH THE STRUCTURE OF BETA-LOCKERS AND A FOOTBALL-ANTAGONIST PORTION
WO2004063195A1 (en) * 2003-01-03 2004-07-29 Sloan-Kettering Institute For Cancer Research Pyridopyrimidine kinase inhibitors
CN109824675A (en) * 2019-04-09 2019-05-31 唐山师范学院 A kind of synthetic method of 4-chloropyrrolopyrimidine

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU4885685A (en) * 1984-10-19 1986-04-24 Godecke Aktiengesellschaft 4-Alkoxy-pyrido (2,3-d) pyrimidine derivatives, process for their preparation and pharmaceutical compositions containing them

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE525394A (en) *
US3673184A (en) * 1970-09-02 1972-06-27 Dainippon Pharmaceutical Co Certain 2-substituted-5,8-dihydro-5-oxopyrido{8 2,3-d{9 pyrimidine-6-carboxylic acid derivatives
US4271164A (en) * 1979-04-16 1981-06-02 Warner-Lambert Company 6-Substituted-arylpyrido[2,3-d]pyrimidin-7-amines and derivatives
US4361700A (en) * 1980-05-20 1982-11-30 James S. Waldron Pyridopyrimidinone derivatives
US4432981A (en) * 1982-11-05 1984-02-21 Sterling Drug Inc. 2-(Pyridinyl or hydroxyphenyl)-8-substituted pyrido[2,3-d]pyrimidin-5(8H)-ones
US4560753A (en) * 1982-11-05 1985-12-24 Sterling Drug Inc. 2-Substituted-pyrido[2,3-d]pyrimidin-5(8H)-ones

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU4885685A (en) * 1984-10-19 1986-04-24 Godecke Aktiengesellschaft 4-Alkoxy-pyrido (2,3-d) pyrimidine derivatives, process for their preparation and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
ATE44743T1 (en) 1989-08-15
DE3438350A1 (en) 1986-04-24
EP0180833A1 (en) 1986-05-14
DE3571619D1 (en) 1989-08-24
CA1260936A (en) 1989-09-26
DD242406A5 (en) 1987-01-28
DK478485A (en) 1986-04-20
CN85107634B (en) 1988-07-06
DK478485D0 (en) 1985-10-18
US4677108A (en) 1987-06-30
AU4885785A (en) 1986-04-24
EP0180833B1 (en) 1989-07-19
ZA857990B (en) 1986-06-25
ES548007A0 (en) 1986-03-16
HUT39180A (en) 1986-08-28
HU192728B (en) 1987-06-29
ES8605518A1 (en) 1986-03-16
JPS61100581A (en) 1986-05-19
CN85107634A (en) 1987-05-13
GR852525B (en) 1986-02-19

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