AU587739B2 - Derivatives of 3'-azido-3'-deoxythymidine - Google Patents

Derivatives of 3'-azido-3'-deoxythymidine

Info

Publication number: AU587739B2
Authority: AU; Australia
Prior art keywords: deoxythymidine; azido; derivatives
Prior art date: 1985-03-16
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Application number

AU12159/88A

Other versions

AU1215988A (en

Inventor

David Walter Barry

George Andrew Freeman

Phillip Allen Furman

Sandra Nusinoff Lehrman

Janet Lister Rideout

Martha Heider St. Clair

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Wellcome Foundation Ltd

Original Assignee

Wellcome Foundation Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-03-16

Filing date

1988-02-24

Publication date

1989-08-24

1985-03-16 Priority claimed from GB858506869A external-priority patent/GB8506869D0/en

1985-05-09 Priority claimed from GB858511774A external-priority patent/GB8511774D0/en

1985-09-27 Priority claimed from GB858523881A external-priority patent/GB8523881D0/en

1986-02-12 Priority claimed from GB868603450A external-priority patent/GB8603450D0/en

1988-02-24 Application filed by Wellcome Foundation Ltd filed Critical Wellcome Foundation Ltd

1988-06-23 Publication of AU1215988A publication Critical patent/AU1215988A/en

1989-08-24 Application granted granted Critical

1989-08-24 Publication of AU587739B2 publication Critical patent/AU587739B2/en

2006-03-14 Anticipated expiration legal-status Critical

Status Expired legal-status Critical Current

Links

HBOMLICNUCNMMY-XLPZGREQSA-N zidovudine Chemical class O=C1NC(=O)C(C)=CN1[C@@H]1O[C@H](CO)[C@@H](N=[N+]=[N-])C1 HBOMLICNUCNMMY-XLPZGREQSA-N 0.000 title 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
- A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/21—Interferons [IFN]
- A61K38/212—IFN-alpha
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Molecular Biology (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Biotechnology (AREA)
Genetics & Genomics (AREA)
Biochemistry (AREA)
Zoology (AREA)
Gastroenterology & Hepatology (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)

AU12159/88A 1985-03-16 1988-02-24 Derivatives of 3'-azido-3'-deoxythymidine Expired AU587739B2 (en)

Applications Claiming Priority (9)

Application Number	Priority Date	Filing Date	Title
GB858506869A GB8506869D0 (en)	1985-03-16	1985-03-16	Antiviral compound
GB8506869		1985-03-16
GB8511774		1985-05-09
GB858511774A GB8511774D0 (en)	1985-05-09	1985-05-09	Antiviral compounds
US776899		1985-09-17
GB858523881A GB8523881D0 (en)	1985-09-27	1985-09-27	Antiviral compounds
GB8523881		1985-09-27
GB868603450A GB8603450D0 (en)	1986-02-12	1986-02-12	Antiviral compounds
GB8603450		1986-02-12

Related Parent Applications (1)

Application Number	Title	Priority Date	Filing Date
AU54758/86A Division AU572019B2 (en)	1985-03-16	1986-03-14	3'-azido-3'-deoxythymidine

Publications (2)

Publication Number	Publication Date
AU1215988A AU1215988A (en)	1988-06-23
AU587739B2 true AU587739B2 (en)	1989-08-24

Family

ID=27449646

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
AU12158/88A Expired AU574620B1 (en)	1985-03-16	1988-02-24	Use of 3'-azido-3'-deoxythymidine
AU12159/88A Expired AU587739B2 (en)	1985-03-16	1988-02-24	Derivatives of 3'-azido-3'-deoxythymidine

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
AU12158/88A Expired AU574620B1 (en)	1985-03-16	1988-02-24	Use of 3'-azido-3'-deoxythymidine

Country Status (5)

Country	Link
KR (1)	KR860006987A (en)
AU (2)	AU574620B1 (en)
ES (2)	ES8800257A1 (en)
HU (2)	HU197209B (en)
PH (1)	PH27190A (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5276019A (en) *	1987-03-25	1994-01-04	The United States Of America As Represented By The Department Of Health And Human Services	Inhibitors for replication of retroviruses and for the expression of oncogene products

Citations (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU578809B2 (en) *	1985-03-16	1988-11-03	Wellcome Foundation Limited, The	Therapeutic nucleosides

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4852127A (en) *	1985-03-22	1989-07-25	American Telephone And Telegraph Company, At&T Bell Laboratories	Universal protocol data receiver

1986
- 1986-03-14 PH PH33532A patent/PH27190A/en unknown
- 1986-03-14 KR KR1019860001836A patent/KR860006987A/en not_active Ceased
- 1986-03-14 HU HU861079A patent/HU197209B/en unknown
- 1986-03-14 HU HU874087A patent/HU199501B/en not_active IP Right Cessation
- 1986-03-14 ES ES553013A patent/ES8800257A1/en not_active Expired
- 1986-11-18 ES ES557209A patent/ES8802469A1/en not_active Expired
1988
- 1988-02-24 AU AU12158/88A patent/AU574620B1/en not_active Expired
- 1988-02-24 AU AU12159/88A patent/AU587739B2/en not_active Expired

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU578809B2 (en) *	1985-03-16	1988-11-03	Wellcome Foundation Limited, The	Therapeutic nucleosides

Also Published As

Publication number	Publication date
ES553013A0 (en)	1987-11-01
AU574620B1 (en)	1988-07-07
HU197209B (en)	1989-03-28
ES8802469A1 (en)	1988-07-16
HUT40570A (en)	1987-01-28
ES557209A0 (en)	1988-07-16
HU199501B (en)	1990-02-28
ES8800257A1 (en)	1987-11-01
PH27190A (en)	1993-04-16
AU1215988A (en)	1988-06-23
KR860006987A (en)	1986-10-06

Publication	Publication Date	Title
AU572019B2 (en)	1988-04-28	3'-azido-3'-deoxythymidine
AU2516888A (en)	1989-05-25	Novel fluoro cytidine derivatives
AU572402B2 (en)	1988-05-05	25-avermectin derivatives
AU5912086A (en)	1986-12-24	Substituted 3-phenyl-cyanopyrrole derivatives
AU1123388A (en)	1988-08-18	Certain adenosine 5'-carboxamide derivatives
AU5821686A (en)	1986-12-04	3-benzazepine derivatives
AU574911B2 (en)	1988-07-14	4' - demethyl - epipodophyllotoxin derivatives
AU6070086A (en)	1987-02-05	Pyridazinone derivatives
AU604663B2 (en)	1991-01-03	Pyrimidine derivatives
AU6150386A (en)	1987-02-19	Guanine derivatives
AU548712B2 (en)	1986-01-02	2:-deoxy-5-substituted uridine derivatives
AU5638686A (en)	1986-10-23	Cyclohexylamidazole derivatives
AU577883B2 (en)	1988-10-06	Amide derivatives
AU5948186A (en)	1987-01-22	Pyrimidine derivatives
AU562773B2 (en)	1987-06-18	Tetrahydroimidazoquinazolinone derivatives
AU581066B2 (en)	1989-02-09	Cyanoalkanimidamidophenylpyridazinone derivatives
AU2166688A (en)	1989-03-02	3'-demethoxyepipodophyllotoxin glucoside derivatives
AU5511986A (en)	1986-10-13	2-arylbenzothiazine derivatives
AU561320B2 (en)	1987-05-07	Clycoside derivatives
AU587739B2 (en)	1989-08-24	Derivatives of 3'-azido-3'-deoxythymidine
AU6550486A (en)	1987-05-21	Thienylsulphonyl guanidine derivatives
NZ214836A (en)	1988-10-28	Preparation of 4,4-dialkyl-2-azetidinone derivatives and intermediates
IL86670A0 (en)	1988-11-30	Preparation of 3'-azido-3'-deoxythymidine and intermediates therefor
AU5417886A (en)	1986-09-11	Derivatives of 5-fluorouracil
AU584448B2 (en)	1989-05-25	Bis-dioxopiperazine derivatives