AU599943B2 - Fusion proteins with a eukaryotic ballast portion - Google Patents
Fusion proteins with a eukaryotic ballast portionInfo
- Publication number
- AU599943B2 AU599943B2 AU66760/86A AU6676086A AU599943B2 AU 599943 B2 AU599943 B2 AU 599943B2 AU 66760/86 A AU66760/86 A AU 66760/86A AU 6676086 A AU6676086 A AU 6676086A AU 599943 B2 AU599943 B2 AU 599943B2
- Authority
- AU
- Australia
- Prior art keywords
- fusion proteins
- eukaryotic
- ballast portion
- amino
- ballast
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 102000037865 fusion proteins Human genes 0.000 title abstract 3
- 108020001507 fusion proteins Proteins 0.000 title abstract 3
- 108010002350 Interleukin-2 Proteins 0.000 abstract 3
- 102000000588 Interleukin-2 Human genes 0.000 abstract 2
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 238000003776 cleavage reaction Methods 0.000 abstract 1
- 238000010276 construction Methods 0.000 abstract 1
- 230000007017 scission Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/53—Colony-stimulating factor [CSF]
- C07K14/535—Granulocyte CSF; Granulocyte-macrophage CSF
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/55—IL-2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
- C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Immunology (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Physics & Mathematics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Plant Pathology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Tropical Medicine & Parasitology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Sampling And Sample Adjustment (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
Suitable as "ballast portion" for fusion proteins is a part of the amino-acid sequence of interleukin-2 (IL-2) which comprises considerably less than 100 amino acids. It is advantageous to start from a synthetic IL-2 gene which is divided by unique cleavage sites into six segments of which up to three can be linked in any desired sequence by the building block principle. Specific constructions allowing the solubility of the fusion protein to be varied are possible.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE3545565 | 1985-12-21 | ||
| DE3545565 | 1985-12-21 | ||
| DE3636903 | 1986-10-30 | ||
| DE19863636903 DE3636903A1 (en) | 1985-12-21 | 1986-10-30 | FUSION PROTEINS WITH EUKARYOTIC BALLASTES |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU6676086A AU6676086A (en) | 1987-06-25 |
| AU599943B2 true AU599943B2 (en) | 1990-08-02 |
Family
ID=25839208
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU66760/86A Expired AU599943B2 (en) | 1985-12-21 | 1986-12-19 | Fusion proteins with a eukaryotic ballast portion |
Country Status (16)
| Country | Link |
|---|---|
| EP (1) | EP0229998B1 (en) |
| JP (2) | JP2553058B2 (en) |
| KR (1) | KR950000301B1 (en) |
| AT (1) | ATE78296T1 (en) |
| AU (1) | AU599943B2 (en) |
| CA (1) | CA1339894C (en) |
| DE (1) | DE3636903A1 (en) |
| DK (1) | DK168823B1 (en) |
| ES (1) | ES2033678T3 (en) |
| FI (1) | FI93734C (en) |
| GR (1) | GR3005985T3 (en) |
| HU (1) | HU209747B (en) |
| IE (1) | IE58935B1 (en) |
| IL (1) | IL81018A (en) |
| NO (1) | NO175003C (en) |
| PT (1) | PT83973B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU637139B2 (en) * | 1985-12-21 | 1993-05-20 | Hoechst Aktiengesellschaft | Gm-csf protein, its derivatives, the preparation of proteins of this type, and their use |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3844211A1 (en) * | 1988-12-29 | 1990-07-05 | Hoechst Ag | NEW INSULINE DERIVATIVES, THE PROCESS FOR THEIR PRODUCTION, THEIR USE AND A PHARMACEUTICAL PREPARATION CONTAINING THEM |
| FR2643646B1 (en) * | 1989-02-27 | 1993-09-17 | Pasteur Institut | EXPRESSION OF NUCLEOTIDES SEQUENCES ENCODING FOR GAS VESICLES |
| CU22222A1 (en) * | 1989-08-03 | 1995-01-31 | Cigb | PROCEDURE FOR THE EXPRESSION OF HETEROLOGICAL PROTEINS PRODUCED IN A FUSION FORM IN ESCHERICHIA COLI, ITS USE, EXPRESSION VECTORS AND RECOMBINANT STRAINS |
| DE3942580A1 (en) * | 1989-12-22 | 1991-06-27 | Basf Ag | METHOD FOR PRODUCING HIRUDINE |
| DE4105480A1 (en) * | 1991-02-21 | 1992-08-27 | Boehringer Mannheim Gmbh | IMPROVED ACTIVATION OF RECOMBINANT PROTEINS |
| PT821006E (en) | 1996-07-26 | 2004-09-30 | Aventis Pharma Gmbh | INSULIN DERIVATIVES WITH ENHANCED ZINC LINK |
| DE19825447A1 (en) | 1998-06-06 | 1999-12-09 | Hoechst Marion Roussel De Gmbh | New insulin analogues with increased zinc formation |
| DE102006031955A1 (en) | 2006-07-11 | 2008-01-17 | Sanofi-Aventis Deutschland Gmbh | Process for the preparation of dibasic B chain end insulin analogs |
| DE102006031962A1 (en) | 2006-07-11 | 2008-01-17 | Sanofi-Aventis Deutschland Gmbh | Amidated insulin glargine |
| RS59913B1 (en) | 2008-10-17 | 2020-03-31 | Sanofi Aventis Deutschland | Combination of an insulin and a glp-1 agonist |
| CN102596175A (en) | 2009-07-06 | 2012-07-18 | 赛诺菲-安万特德国有限公司 | Aqueous insulin preparations containing methionine |
| MY180661A (en) | 2009-11-13 | 2020-12-04 | Sanofi Aventis Deutschland | Pharmaceutical composition comprising a glp-1 agonist, an insulin and methionine |
| PT3345593T (en) | 2009-11-13 | 2023-11-27 | Sanofi Aventis Deutschland | Pharmaceutical composition comprising despro36exendin-4(1-39)-lys6-nh2 and methionine |
| PL2611458T3 (en) | 2010-08-30 | 2017-02-28 | Sanofi-Aventis Deutschland Gmbh | Use of ave0010 for the manufacture of a medicament for the treatment of diabetes mellitus type 2 |
| US9821032B2 (en) | 2011-05-13 | 2017-11-21 | Sanofi-Aventis Deutschland Gmbh | Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin |
| AR087693A1 (en) | 2011-08-29 | 2014-04-09 | Sanofi Aventis Deutschland | PHARMACEUTICAL COMBINATION FOR USE IN GLUCEMIC CONTROL IN PATIENTS WITH TYPE 2 DIABETES |
| TWI559929B (en) | 2011-09-01 | 2016-12-01 | Sanofi Aventis Deutschland | Pharmaceutical composition for use in the treatment of a neurodegenerative disease |
| EP3229828B1 (en) | 2014-12-12 | 2023-04-05 | Sanofi-Aventis Deutschland GmbH | Insulin glargine/lixisenatide fixed ratio formulation |
| TWI748945B (en) | 2015-03-13 | 2021-12-11 | 德商賽諾菲阿凡提斯德意志有限公司 | Treatment type 2 diabetes mellitus patients |
| TW201705975A (en) | 2015-03-18 | 2017-02-16 | 賽諾菲阿凡提斯德意志有限公司 | Treatment of type 2 diabetes mellitus patients |
| KR20200080748A (en) | 2018-12-27 | 2020-07-07 | 주식회사 폴루스 | A Method for Purifying Proinsulin Using Anion Exchange Chromatography |
| KR20200080747A (en) | 2018-12-27 | 2020-07-07 | 주식회사 폴루스 | An Enzymatic Conversion Composition for Producing Insulin from Proinsulin and a Method for Producing Insulin from Proinsulin Using the Same |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK108685A (en) * | 1984-03-19 | 1985-09-20 | Fujisawa Pharmaceutical Co | GROWTH FACTOR I |
| EP0158198A1 (en) * | 1984-03-29 | 1985-10-16 | Takeda Chemical Industries, Ltd. | DNA and use thereof |
| GB8412517D0 (en) * | 1984-05-16 | 1984-06-20 | Nagai K | Recombinant fusion proteins |
-
1986
- 1986-10-30 DE DE19863636903 patent/DE3636903A1/en not_active Withdrawn
- 1986-12-16 ES ES198686117481T patent/ES2033678T3/en not_active Expired - Lifetime
- 1986-12-16 AT AT86117481T patent/ATE78296T1/en not_active IP Right Cessation
- 1986-12-16 EP EP86117481A patent/EP0229998B1/en not_active Expired - Lifetime
- 1986-12-18 FI FI865187A patent/FI93734C/en not_active IP Right Cessation
- 1986-12-18 IL IL81018A patent/IL81018A/en not_active IP Right Cessation
- 1986-12-19 CA CA000525858A patent/CA1339894C/en not_active Expired - Lifetime
- 1986-12-19 PT PT83973A patent/PT83973B/en unknown
- 1986-12-19 NO NO865192A patent/NO175003C/en not_active IP Right Cessation
- 1986-12-19 DK DK619186A patent/DK168823B1/en not_active IP Right Cessation
- 1986-12-19 IE IE333486A patent/IE58935B1/en not_active IP Right Cessation
- 1986-12-19 AU AU66760/86A patent/AU599943B2/en not_active Expired
- 1986-12-19 HU HU865354A patent/HU209747B/en unknown
- 1986-12-20 KR KR1019860011010A patent/KR950000301B1/en not_active Expired - Lifetime
- 1986-12-22 JP JP61306185A patent/JP2553058B2/en not_active Expired - Lifetime
-
1992
- 1992-10-15 GR GR920402187T patent/GR3005985T3/el unknown
-
1995
- 1995-10-11 JP JP7263310A patent/JP2774260B2/en not_active Expired - Lifetime
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU637139B2 (en) * | 1985-12-21 | 1993-05-20 | Hoechst Aktiengesellschaft | Gm-csf protein, its derivatives, the preparation of proteins of this type, and their use |
Also Published As
| Publication number | Publication date |
|---|---|
| CA1339894C (en) | 1998-06-02 |
| FI93734C (en) | 1995-05-26 |
| NO175003B (en) | 1994-05-09 |
| IL81018A (en) | 1992-03-29 |
| EP0229998A2 (en) | 1987-07-29 |
| GR3005985T3 (en) | 1993-06-07 |
| NO175003C (en) | 1994-08-17 |
| JPS62167799A (en) | 1987-07-24 |
| DE3636903A1 (en) | 1987-07-02 |
| ES2033678T3 (en) | 1993-04-01 |
| KR870006187A (en) | 1987-07-09 |
| DK619186A (en) | 1987-06-22 |
| PT83973A (en) | 1987-01-01 |
| JPH08187089A (en) | 1996-07-23 |
| FI865187L (en) | 1987-06-22 |
| DK619186D0 (en) | 1986-12-19 |
| FI93734B (en) | 1995-02-15 |
| FI865187A0 (en) | 1986-12-18 |
| DK168823B1 (en) | 1994-06-20 |
| JP2774260B2 (en) | 1998-07-09 |
| IE863334L (en) | 1987-06-21 |
| KR950000301B1 (en) | 1995-01-13 |
| JP2553058B2 (en) | 1996-11-13 |
| PT83973B (en) | 1989-07-31 |
| HUT44614A (en) | 1988-03-28 |
| EP0229998A3 (en) | 1988-08-03 |
| HU209747B (en) | 1994-10-28 |
| IL81018A0 (en) | 1987-03-31 |
| ATE78296T1 (en) | 1992-08-15 |
| AU6676086A (en) | 1987-06-25 |
| EP0229998B1 (en) | 1992-07-15 |
| IE58935B1 (en) | 1993-12-01 |
| NO865192L (en) | 1987-06-22 |
| NO865192D0 (en) | 1986-12-19 |
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