AU607772B2 - Disinfectant compositions - Google Patents

Description

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0 1.25 1. I16 1.2521 4 COMMONWEALTH OF AUSTRAOW7 7 7Frm1 PATENTS ACT 1952-62 COMPLETE SPECIFICATION

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FOR OFFICE USE: Application Number: Lodged: Class Int. Class Complete Specification Lodged: Accepted: Published: R;LV'e-Art: 'liis d'mcntcontains thic anc~h: -~';made nr edton 9> al is correct fol.

priiiting Napnepf Applicant: 0 0 TO BE COMPLETED BY APPLICANT EVTANS VANODINE INTERNATIONAL LIMITED Address of Applicant: 0 .11 00 0' Brierley Road, Walton Summit Centre, Bamber Bridge, Preston, Lancashire, 8AH, England Actual Inventors: Derek Anthony EVANS, Gordon William GRIMSHAW and Valerie Joyce Christine PURDY I I

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Ac4dr~e,s for Service: R K Maddern Associates, 345 King William Street, Adelaide, State of South Australia, Commonwealth of Australia Complete Specification for the invention entitled: "DISINFECTANT COMPOSITIONS" The following statement is a full description of this invention, including the best method of performing it known to PA& us.

1- May be signed by Australian Patent Attorney.

My/Our address for service is care of R. K. MADDERN and ASSOCIATES, Patent Attorneys.

King William Street, Adelaide, South Australia 5000.

345 Dated this 15th day of Ju 19 88.

EVANS VANODINE INTERNATIONAL LI ITED By its Patent Attorneys R K MADDERN ASSOCIATES R S CATT j: 1~ i? j ::y 7

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ABSTRACT

DISINFECTANT COMPOSITIONS A disinfectant composition comprises a mixture with water of glutaraldehyde, a cationic -ntibacterial compound such as a quaternary ammonium compound, a surfactant particularly of a non-ionic kind, and an acid such as phosphoric acid to give an acidic ?H prticularly in the range 1.5 to 2.5 for the concentrated composition. The composition may be stored in concentrated form and diluted prior to use, or may be stored in a partially or completely ready-for-use) diluted form.

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Lr- 1 iH 'c Paragraph 4-strike out Declared at WALTON SUMMIT this SIXTH day of NOVEMBER 19 applicable.

Paragraph 4 aus zustreichen wenn Rueckseite zutrifft, Signature(s) of declarant(s).

Unterschrift(en) des/dr Deklaranten.

(Note. No attestation or other signature is DEREK ANTHONY EVANS required).

Bemerkung. Beglaubigung der Unterschrift ist nicht benoetigt.

To: The Commissioner of Patents, Commonwealth of Australia.

R. K. MADDERN and ASSOCIATES, Citicorp House 345 King William S et, Adelaide South Australia 5000, i it I *r Ia.

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C- (C DISINFECTANT COMPOSITIONS This invention relates to disinfectant compositions. The compositions of the invention are especially useful in an agricultural context for disinfecting animal accommodation, such as poultry cages and cattle sheds, to prevent spread of diseases. However, the compositions may also be useful for other purposes.

For use in disinfecting poultry cages and cattle sheds a disinfectant is required which has a wide-ranging powerful action against bacteria, viruses and fungi. Iodophors, that is, solutions of iodine in aqueous 10. surfactant are particularly effective but can give rise to staining and/or corrosion problems.

An object of the present invention is to provide an effective agricultural disinfectant with which staining and corrosion problems can be avoided or at least minimised and which is a relatively inexpensive 15. and convenient formulation.

According to the invention therefore there is provided a disinfectant composition comprising an aqueous mixture, of glutaraldehyde, a cationic anti-bacterial compound, a surfactant and an acid.

Glutaraldehyde has known disinfectant properties. In particular it has been used for sterilising instruments in hospitals. However, in this known application the practice has been to use glutaraldehyde as the sole disinfectant substance in an aqueous alkaline medium. More specifically, a disinfectant composition .is made up immediately prior to use by mixing slightly acidified glutaraldehyde with water and an alkali, the reason for this procedure being that glutaraldehyde is i S 2 2storage stable when slightly acidified but is considered to have better disinfectant action at neutral or alkaline pH.

In accordance with the present invention it has been found that excellent disinfectant activity can be achieved in aqueous acidic conditions if the glutaraldehyde is formulated with a surfactant and a cationic anti-bacterial compound. Accordingly, the invention provides an effective, storage stable disinfectant composition which can be Goof, formulated in a convenient and relatively inexpensive manner and which, 0 S' having regard to the relatively innocuous nature of the glutaraldehyde, need not give rise to staining or corrosion problems.

The storage stable composition may be prepared as a fully made-up ready-for-use disinfectant. Alternatively it may be made up as a i OD.. concentrate to be diluted by addition of water prior to use e.g. at a q. dilution in the range 1:20 or 1:50 to 1:200 (concentrate:water by

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volume) depending on the intended use. Dilution assists storage stability and at least partial dilution may be desirable the concentrate may be stored diluted to half the ready-for-use dilution).

With reference to a concentrate intended to be diluted prior to S' use, the proportions by weight may be Glutaraldehyde particularly 8% to 16% preferably 12% Cationic compound preferably 4% Surfactant 4%-12% preferably 8% Acid up to 3% preferably 0.5 to particularly 0.8%.

With regard to the cationic compound this may be any suitablei substance although preferably a quaternary ammonium compound is used, particularly didecyl dimethyl ammonium chloride because this r 1 -3chloride.

The surfactant is preferably a non-ionic surfactant. Preferably the surfactant is of the biodegradable fatty alcohol ethoxylate kind 999 .4 particularly having an HLB of 11 to 14. Alternatively, the surfactant may be of the alkyl phenol ethoxylate kind particularly a nonyl phenol *o 10. 6 to 12 mole ethoxylate having an HLB of 11 to 14 (especially nonyl phenol 8 mole ethoxylate of HLB 12.2.

With regard to the acid, this is preferably such as to give a pH in the range 1.5 to 2.5 in the concentrate thereby to ensure that an *O acidic pH is maintained even when the concentrate is diluted with S 15. hard (alkaline) water. Accordingly, a relatively strong acid is preferred oo o and phosphoric acid is particularly preferred. Other acids, such as citric acid and sulphuric acid could be used but phosphoric acid is advantageous because it does not give rise to undue problems of corrosion of metal surfaces.

Other minor ingredients may be incorporated as desired e.g.

I isopropyl alcohol to assist in dissolving the cationic compound, colouring substances etc.

The invention will now be described further in the following example.

Example The following ingredients were mixed with stirring in the stated -4 proportions (of active ingredients) by weight: Glutaraldehyde 12% Didecyl dimethyl ammonium chloride 4% Synperonic A7 (ICI Limited) 8% Phosphoric acid 0.8% Water (de-ionised) to 100% Synperonic A7 is a biodegradable surfactant of C 1 3

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1 5 fatty alcohol 7 mole ethylene oxide of HLB value 12.2 and cloud point 0000 o 46-480C.

S 10. The resulting mixture was a clear low viscosity yellow liquid 0o having a pH of approximately 1.9 and a specific gravity of 1.035 at *00090 0

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0 This mixture is storage stable and is suitable for use, after dilution with water, at a dilution level in the range 1:20 to 1:200, for example for disinfecting farm buildings for animals such as poultry houses and calf sheds and structures and equipment within such buildings such as poultry cages, tubing, feeding and drinking apparatus whether made from wood, metal or plastics. The diluted mixture may be used as a wash for manual application, for dipping/soaking equipment, and for spray application. By way of example, a dilution of 1:200 may be appropriate for disinfection of pre-cleaned equipment i and 1:50 for disinfection of buildings after removal of litter and precleaning with detergent. Particularly (although not necessarily) at a ready-for-use dilution of 1:50, the mixture may be suitable for use in hospitals for disinfecting implements or for other uses in a human context.

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A(4IIr Moreover, the mixture can be used in a veterinary context for example for disinfecting examination tables, small animal cages and associated implements and apparatus.

The mixture has good bactericidal activity against a range of bacteria commonly encountered in animal houses (such as Escherichia coli). It also has good virucidal activity against canine parvovirus and other members of the genus such as porcine parvovirus and parvovirus of mink). It is also fungicidal being effective for example against Trichophyton mentagrophytes and Microsporum canis. The 10. mixture also has wide spectrum activity against human and animal bacteria, viruses and fungi.

The mixture is an acceptable clear liquid which has little tendency to cause staining or corrosion.

The pH of the diluted mixture will depend on the hardness of the water used for dilution purposes. With soft water it is possible that the pH may not change appreciably from the pH of the concentrate.

With hard water the pH may rise perhaps to a value in the range 3 to However, in general, the diluted mixture will always have an acid pH and excellent disinfectant properties are attained as a consequence of the formulation of the glutaraldehyde with the surfactant and the quaternary ammonium compound in such acid conditions.

It is of course to be understood that the invention is not intended to be restricted to the details of the above Example.

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Claims (9)

1. A disinfectant composition having a pH of 1.5 to 2.5, and comprising an aqueous mixture of glutaraldehyde, a cationic anti-bacterial compound, a surfactant and an acid.

2. A composition according to claim 1, wherein the cationic compound is a quaternary ammonium compound.

3. A composition according to claim 2, wherein the quaternary ammonium compound is didecyl dimethyl ammonium chloride.

4. A composition according to any one of claims 1 to 3, wherein the surfactant is an alkyl phenol ethoxylate of HLB 11 to 14. A composition according to claim 4, wherein the alkyl phenol ethoxylate is a nonyl phenol 6 to 12 mole ethoxylate.

6. A composition according to claim 5, wherein the surfactant is nonyl phenol 8 mole ethoxylate.

7. A composition according to any one of claims 1 to 3, wherein the surfactant is a fatty alcohol ethoxylate having an HLB of 11 to 14.

8. A composition according to claim 7, wherein the surfactant is a C 13 -C 15 fatty alcohol 7 mole ethoxylate.

9. A composition according to any one of claims 1 to 8, wherein the acid comprises phosphoric acid. A composition according to claim 1, comprising with water: Glutaraldehye 5 to 20% by weight Cationic compound 2 to 6% by weight Surfactar' 4 to 12% by weight Acid 0.5 to 3% by weight 1: i! :,i i 1 ;f ii .1 B I; ii i: e ii i y iiL

11. A composition according to claim 1, substantially as hereinbefore described in the Example. Dated this 6th day of December, 1990. EVANS VANODINE INTERNATIONAL LIMITED, By its Patent Attorneys, R.K. MADDERN ASSOCIATES. 0 0*00 0 9~ 0 o 0 00 0* o 0 0 0 0 0 o 008 'A 0 Wee C 0 @0 I 4 0 0401 0 4 I- f* I: 4