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AU614489B2 - Compositions and methods for clones containing dna sequences associated with multidrug resistance in human cells - Google Patents
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AU614489B2 - Compositions and methods for clones containing dna sequences associated with multidrug resistance in human cells - Google Patents

Compositions and methods for clones containing dna sequences associated with multidrug resistance in human cells

Info

Publication number
AU614489B2
AU614489B2 AU72861/87A AU7286187A AU614489B2 AU 614489 B2 AU614489 B2 AU 614489B2 AU 72861/87 A AU72861/87 A AU 72861/87A AU 7286187 A AU7286187 A AU 7286187A AU 614489 B2 AU614489 B2 AU 614489B2
Authority
AU
Australia
Prior art keywords
compositions
methods
dna sequences
human cells
containing dna
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
AU72861/87A
Other versions
AU7286187A (en
Inventor
Michael M. Gottesman
Ira H. Pastan
Igor B. Roninson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Illinois System
Original Assignee
University of Illinois at Urbana Champaign
University of Illinois System
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27126587&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AU614489(B2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by University of Illinois at Urbana Champaign, University of Illinois System filed Critical University of Illinois at Urbana Champaign
Publication of AU7286187A publication Critical patent/AU7286187A/en
Application granted granted Critical
Publication of AU614489B2 publication Critical patent/AU614489B2/en
Anticipated expiration legal-status Critical
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Genomic and cDNA clones of human genes which are selectively amplified or overexpressed in multidrugresistant human tumor cells were isolated. Such clones may be used as probes in diagnostic tests to detect chemotherapy-resistant tumor cells and to predict tumor response to chemotherapy. The complete nucleotide sequence of the coding region of the human mdr1 gene and the complete corresponding amino acid sequence are disclosed.
AU72861/87A 1986-03-28 1987-03-26 Compositions and methods for clones containing dna sequences associated with multidrug resistance in human cells Expired AU614489B2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US84561086A 1986-03-28 1986-03-28
US845610 1986-03-28
US89257586A 1986-08-01 1986-08-01
US892575 1986-08-01

Publications (2)

Publication Number Publication Date
AU7286187A AU7286187A (en) 1987-10-20
AU614489B2 true AU614489B2 (en) 1991-09-05

Family

ID=27126587

Family Applications (1)

Application Number Title Priority Date Filing Date
AU72861/87A Expired AU614489B2 (en) 1986-03-28 1987-03-26 Compositions and methods for clones containing dna sequences associated with multidrug resistance in human cells

Country Status (7)

Country Link
EP (1) EP0274482B2 (en)
JP (1) JP2634833B2 (en)
AT (1) ATE122727T1 (en)
AU (1) AU614489B2 (en)
CA (1) CA1341013C (en)
DE (1) DE3751307T2 (en)
WO (1) WO1987005943A1 (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4837306A (en) * 1985-02-25 1989-06-06 The Ontario Cancer Institute Method for selecting hybridomas producing antibodies specific to the P-glycoprotein cell suface antigen and a cDNA clone encoding the C-terminal portion of the antigen
US5085983A (en) * 1988-08-19 1992-02-04 City Of Hope Detection of human tumor progression and drug resistance
US5399483A (en) * 1989-03-30 1995-03-21 Suntory Limited Expression of MDR-related gene in yeast cell
WO1992001811A1 (en) * 1990-07-25 1992-02-06 Imperial Cancer Research Technology Limited Assay for ctp-synthetase mutations which cause multidrug resistance
WO1992008802A1 (en) * 1990-10-29 1992-05-29 Cetus Oncology Corporation Bispecific antibodies, method of production, and uses thereof
US6130059A (en) * 1992-03-02 2000-10-10 Covacci; Antonello Helicobacter pylori proteins useful for vaccines and diagnostics
DE69333110T2 (en) 1992-03-02 2004-05-06 Chiron S.P.A. WITH THE CYTOTOXIN OF HELICOBACTER PYLORI ASSOCIATED, IMMUNODOMINANT ANTIGEN USED IN VACCINE AND FOR DIAGNOSIS
US7141244B1 (en) 1992-03-02 2006-11-28 Chiron Srl Helicobacter pylori proteins useful for vaccines and diagnostics
US5489519A (en) * 1992-10-27 1996-02-06 Queen's University At Kingston Multidrug resistance protein
AU5420494A (en) * 1992-11-02 1994-05-24 Yves Claude Nicolau Method of reducing multidrug resistance in cells and tissues
FR2729295A1 (en) 1995-01-17 1996-07-19 Rhone Poulenc Rorer Sa COMBINED THERAPEUTIC TREATMENT OF HYPERPROLIFERATIVE CONDITIONS
GB2324093A (en) 1996-01-04 1998-10-14 Rican Limited Helicobacter pylori bacterioferritin
EP1220917A1 (en) * 1999-09-28 2002-07-10 Gentest Corporation P-glycoproteins from macaca fascicularis and uses thereof
EP1421101A4 (en) 2001-03-19 2005-01-19 Gentest Corp P-glycoproteins and uses thereof
WO2003025174A2 (en) * 2001-09-06 2003-03-27 Bayer Healthcare Ag Regulation of human mrp1-like protein

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0174870A2 (en) * 1984-09-13 1986-03-19 Globe Products Inc. Flat coil dynamoelectric device, preform therefor, and method and apparatus for use in their manufacture

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0174810B1 (en) * 1984-09-10 1993-07-21 HSC Research Development Corporation Multidrug resistance in mammalian cell lines and isolation of determinant glycoprotein dna

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0174870A2 (en) * 1984-09-13 1986-03-19 Globe Products Inc. Flat coil dynamoelectric device, preform therefor, and method and apparatus for use in their manufacture

Also Published As

Publication number Publication date
AU7286187A (en) 1987-10-20
JPH01500480A (en) 1989-02-23
EP0274482A1 (en) 1988-07-20
JP2634833B2 (en) 1997-07-30
EP0274482B1 (en) 1995-05-17
CA1341013C (en) 2000-06-06
DE3751307T2 (en) 1995-09-21
DE3751307D1 (en) 1995-06-22
EP0274482A4 (en) 1989-05-23
EP0274482B2 (en) 2003-03-12
ATE122727T1 (en) 1995-06-15
WO1987005943A1 (en) 1987-10-08

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