AU640400B2 - Tumour necrosis factor binding ligands - Google Patents
Tumour necrosis factor binding ligands Download PDFInfo
- Publication number
- AU640400B2 AU640400B2 AU61454/90A AU6145490A AU640400B2 AU 640400 B2 AU640400 B2 AU 640400B2 AU 61454/90 A AU61454/90 A AU 61454/90A AU 6145490 A AU6145490 A AU 6145490A AU 640400 B2 AU640400 B2 AU 640400B2
- Authority
- AU
- Australia
- Prior art keywords
- tnf
- ligand
- binding
- binds
- residues
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/241—Tumor Necrosis Factors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
- A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
- A61K47/6813—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin the drug being a peptidic cytokine, e.g. an interleukin or interferon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU61454/90A AU640400B2 (en) | 1989-08-07 | 1990-08-07 | Tumour necrosis factor binding ligands |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AUPJ566289 | 1989-08-07 | ||
| AUPJ5662 | 1989-08-07 | ||
| AUPJ757689 | 1989-11-24 | ||
| AUPJ7576 | 1989-11-24 | ||
| AU61454/90A AU640400B2 (en) | 1989-08-07 | 1990-08-07 | Tumour necrosis factor binding ligands |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU6145490A AU6145490A (en) | 1991-03-11 |
| AU640400B2 true AU640400B2 (en) | 1993-08-26 |
Family
ID=25643730
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU61454/90A Expired AU640400B2 (en) | 1989-08-07 | 1990-08-07 | Tumour necrosis factor binding ligands |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US7605233B2 (fr) |
| EP (1) | EP0486526B2 (fr) |
| JP (7) | JP3443119B2 (fr) |
| AU (1) | AU640400B2 (fr) |
| CA (1) | CA2064915C (fr) |
| DE (2) | DE10399036I1 (fr) |
| DK (1) | DK0486526T3 (fr) |
| WO (1) | WO1991002078A1 (fr) |
Families Citing this family (151)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3443119B2 (ja) * | 1989-08-07 | 2003-09-02 | ペプテック リミテッド | 腫瘍壊死因子結合リガンド |
| US20030225254A1 (en) | 1989-08-07 | 2003-12-04 | Rathjen Deborah Ann | Tumour necrosis factor binding ligands |
| US6451983B2 (en) | 1989-08-07 | 2002-09-17 | Peptech Limited | Tumor necrosis factor antibodies |
| US5959087A (en) | 1989-08-07 | 1999-09-28 | Peptide Technology, Ltd. | Tumour necrosis factor binding ligands |
| JPH05501351A (ja) * | 1989-08-16 | 1993-03-18 | カイロン コーポレイション | プロホルモンタンパク質に対する開裂部位阻止抗体及びその使用 |
| EP0939121B2 (fr) | 1989-09-12 | 2007-12-26 | AHP Manufacturing B.V. | Protéines liant le TNF |
| US5587457A (en) * | 1990-03-12 | 1996-12-24 | Peptide Technology Limited | Neutrophil stimulating peptides |
| US6375928B1 (en) | 1990-03-12 | 2002-04-23 | Peptech Limited | Neutrophil stimulating peptides |
| SG46398A1 (en) * | 1990-03-12 | 1998-02-20 | Peptide Technology Ltd | Neutrophil stimulating peptides |
| EP0521918A4 (en) * | 1990-03-19 | 1993-05-05 | Peptide Technology Ltd | Anti-tumour peptides |
| WO1992002822A1 (fr) * | 1990-08-06 | 1992-02-20 | Cetus Corporation | Procedes d'identification d'inhibiteurs de convertase de cytokine |
| AU654501B2 (en) * | 1990-08-27 | 1994-11-10 | Peptide Technology Ltd. | Method of treating viral infection |
| US5919452A (en) * | 1991-03-18 | 1999-07-06 | New York University | Methods of treating TNFα-mediated disease using chimeric anti-TNF antibodies |
| US6277969B1 (en) | 1991-03-18 | 2001-08-21 | New York University | Anti-TNF antibodies and peptides of human tumor necrosis factor |
| US6284471B1 (en) | 1991-03-18 | 2001-09-04 | New York University Medical Center | Anti-TNFa antibodies and assays employing anti-TNFa antibodies |
| US7192584B2 (en) | 1991-03-18 | 2007-03-20 | Centocor, Inc. | Methods of treating psoriasis with anti-TNF antibodies |
| EP1857553A1 (fr) * | 1991-03-18 | 2007-11-21 | New York University | Anticorps monoclonaux et chimériques spécifiques pour le facteur onconécrosant humain |
| US5698195A (en) * | 1991-03-18 | 1997-12-16 | New York University Medical Center | Methods of treating rheumatoid arthritis using chimeric anti-TNF antibodies |
| US5656272A (en) * | 1991-03-18 | 1997-08-12 | New York University Medical Center | Methods of treating TNF-α-mediated Crohn's disease using chimeric anti-TNF antibodies |
| US5795859A (en) * | 1991-07-05 | 1998-08-18 | Peptide Technology Limited | Peptide which abrogates TNF and/or LPS toxicity |
| WO1993004375A1 (fr) * | 1991-08-23 | 1993-03-04 | Nchip, Inc. | Techniques de gravure par le feu destinees a des circuits integres non conditionnes |
| GB2260902A (en) * | 1991-09-12 | 1993-05-05 | Eurocetus Bv | Interleukin-2 and tumour necrosis factor for treating bladder cancer |
| PT1024191E (pt) | 1991-12-02 | 2008-12-22 | Medical Res Council | Produção de auto-anticorpos a partir de reportórios de segmentos de anticorpo e exibidos em fagos |
| US6270766B1 (en) | 1992-10-08 | 2001-08-07 | The Kennedy Institute Of Rheumatology | Anti-TNF antibodies and methotrexate in the treatment of arthritis and crohn's disease |
| US6274552B1 (en) | 1993-03-18 | 2001-08-14 | Cytimmune Sciences, Inc. | Composition and method for delivery of biologically-active factors |
| CA2158475C (fr) * | 1993-03-18 | 2009-06-02 | Lawrence Tamarkin | Composition et methode pour la reduction de facteurs biologiquement actifs |
| ATE183513T1 (de) * | 1993-06-03 | 1999-09-15 | Therapeutic Antibodies Inc | Herstellung von antikörperfragmenten |
| US5958409A (en) * | 1993-07-30 | 1999-09-28 | Kennedy Institute Of Rheumatology | Method for treating multiple sclerosis |
| US20010055581A1 (en) | 1994-03-18 | 2001-12-27 | Lawrence Tamarkin | Composition and method for delivery of biologically-active factors |
| AU2365795A (en) * | 1995-04-20 | 1996-11-07 | Centocor Inc. | Multiple administrations of anti-tnf antibody |
| US7429646B1 (en) | 1995-06-05 | 2008-09-30 | Human Genome Sciences, Inc. | Antibodies to human tumor necrosis factor receptor-like 2 |
| US7427492B1 (en) | 1995-06-05 | 2008-09-23 | Human Genome Sciences, Inc. | Polynucleotides encoding human tumor necrosis factor receptor-like2 |
| US6090382A (en) | 1996-02-09 | 2000-07-18 | Basf Aktiengesellschaft | Human antibodies that bind human TNFα |
| MX336813B (es) | 1996-02-09 | 2016-02-02 | Abbvie Biotechnology Ltd | Anticuerpos humanos que ligan el tnfa humano. |
| US7229841B2 (en) | 2001-04-30 | 2007-06-12 | Cytimmune Sciences, Inc. | Colloidal metal compositions and methods |
| US6407218B1 (en) | 1997-11-10 | 2002-06-18 | Cytimmune Sciences, Inc. | Method and compositions for enhancing immune response and for the production of in vitro mabs |
| WO2000056405A2 (fr) * | 1999-03-22 | 2000-09-28 | Human Genome Sciences, Inc. | Recepteur tr2 du facteur de necrose tumorale chez l'homme |
| US6579522B1 (en) * | 2000-06-27 | 2003-06-17 | Genvec, Inc. | Replication deficient adenoviral TNF vector |
| UA81743C2 (uk) | 2000-08-07 | 2008-02-11 | Центокор, Инк. | МОНОКЛОНАЛЬНЕ АНТИТІЛО ЛЮДИНИ, ЩО СПЕЦИФІЧНО ЗВ'ЯЗУЄТЬСЯ З ФАКТОРОМ НЕКРОЗУ ПУХЛИН АЛЬФА (ФНПα), ФАРМАЦЕВТИЧНА КОМПОЗИЦІЯ, ЩО ЙОГО МІСТИТЬ, ТА СПОСІБ ЛІКУВАННЯ РЕВМАТОЇДНОГО АРТРИТУ |
| US6902734B2 (en) | 2000-08-07 | 2005-06-07 | Centocor, Inc. | Anti-IL-12 antibodies and compositions thereof |
| US7288390B2 (en) | 2000-08-07 | 2007-10-30 | Centocor, Inc. | Anti-dual integrin antibodies, compositions, methods and uses |
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| US8895540B2 (en) | 2003-11-26 | 2014-11-25 | DePuy Synthes Products, LLC | Local intraosseous administration of bone forming agents and anti-resorptive agents, and devices therefor |
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| HUE034269T2 (en) | 2005-12-29 | 2018-02-28 | Janssen Biotech Inc | Human anti-IL-23 antibodies, preparations, methods and applications |
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| HUE048024T2 (hu) | 2006-08-10 | 2020-05-28 | Roy C Levitt | Anakinra bronchiolitis obliterans szindróma kezelésében való alkalmazásra |
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| US8062864B2 (en) | 2007-05-21 | 2011-11-22 | Alderbio Holdings Llc | Nucleic acids encoding antibodies to IL-6, and recombinant production of anti-IL-6 antibodies |
| US8252286B2 (en) | 2007-05-21 | 2012-08-28 | Alderbio Holdings Llc | Antagonists of IL-6 to prevent or treat thrombosis |
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- 1990-08-07 WO PCT/AU1990/000337 patent/WO1991002078A1/fr not_active Ceased
- 1990-08-07 DE DE69027121T patent/DE69027121T3/de not_active Expired - Lifetime
- 1990-08-07 AU AU61454/90A patent/AU640400B2/en not_active Expired
- 1990-08-07 CA CA002064915A patent/CA2064915C/fr not_active Expired - Lifetime
-
2002
- 2002-08-09 JP JP2002234004A patent/JP3717466B2/ja not_active Expired - Lifetime
-
2003
- 2003-01-31 JP JP2003024901A patent/JP2003231699A/ja active Pending
-
2005
- 2005-12-06 JP JP2005352530A patent/JP3977395B2/ja not_active Expired - Lifetime
-
2007
- 2007-04-19 JP JP2007110836A patent/JP2007197458A/ja not_active Withdrawn
- 2007-06-11 US US11/761,228 patent/US7605233B2/en not_active Expired - Fee Related
-
2008
- 2008-01-31 JP JP2008021278A patent/JP2008174559A/ja active Pending
-
2009
- 2009-03-04 JP JP2009051178A patent/JP4469013B2/ja not_active Expired - Lifetime
- 2009-09-10 US US12/557,309 patent/US20100125130A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| JPH04507195A (ja) | 1992-12-17 |
| DK0486526T3 (da) | 1996-06-24 |
| EP0486526B1 (fr) | 1996-05-22 |
| JP2003096096A (ja) | 2003-04-03 |
| US7605233B2 (en) | 2009-10-20 |
| WO1991002078A1 (fr) | 1991-02-21 |
| EP0486526B2 (fr) | 2001-03-07 |
| JP2009114218A (ja) | 2009-05-28 |
| EP0486526A4 (en) | 1993-05-05 |
| EP0486526A1 (fr) | 1992-05-27 |
| DE69027121D1 (de) | 1996-06-27 |
| US20080234469A1 (en) | 2008-09-25 |
| JP4469013B2 (ja) | 2010-05-26 |
| CA2064915A1 (fr) | 1991-02-08 |
| DE10399036I1 (de) | 2004-04-01 |
| JP2008174559A (ja) | 2008-07-31 |
| AU6145490A (en) | 1991-03-11 |
| JP3717466B2 (ja) | 2005-11-16 |
| JP3977395B2 (ja) | 2007-09-19 |
| DE69027121T3 (de) | 2001-08-30 |
| JP2007197458A (ja) | 2007-08-09 |
| US20100125130A1 (en) | 2010-05-20 |
| JP3443119B2 (ja) | 2003-09-02 |
| JP2003231699A (ja) | 2003-08-19 |
| JP2006089503A (ja) | 2006-04-06 |
| CA2064915C (fr) | 2001-05-29 |
| DE69027121T2 (de) | 1996-11-14 |
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