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AU650074B2 - 9-halogen-11beta -hydroxy prostaglandin derivative, process for producing it and its use as a medicament - Google Patents
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AU650074B2 - 9-halogen-11beta -hydroxy prostaglandin derivative, process for producing it and its use as a medicament - Google Patents

9-halogen-11beta -hydroxy prostaglandin derivative, process for producing it and its use as a medicament

Info

Publication number
AU650074B2
AU650074B2 AU88726/91A AU8872691A AU650074B2 AU 650074 B2 AU650074 B2 AU 650074B2 AU 88726/91 A AU88726/91 A AU 88726/91A AU 8872691 A AU8872691 A AU 8872691A AU 650074 B2 AU650074 B2 AU 650074B2
Authority
AU
Australia
Prior art keywords
radical
halogen
producing
11beta
medicament
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU88726/91A
Other versions
AU8872691A (en
Inventor
Bernd Buchmann
Werner Skuballa
Karl-Heinz Thierauch
Peter Verhallen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering AG filed Critical Schering AG
Publication of AU8872691A publication Critical patent/AU8872691A/en
Application granted granted Critical
Publication of AU650074B2 publication Critical patent/AU650074B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention relates to 9-halogen-11 beta -hydroxy prostaglandin derivatives of formula (I) in which Z is the radical (a) or (b), Hal is an alpha or beta -fixed chlorine or fluorine atom, R<1> is the radical CH2OH or (c), R<2> is a hydrogen atom, an alkyl, cycloalkyl, aryl or heterocyclic radical or R<1> is the radical (d), where R<3> is an acid radical or the radical R<2> and R<4> is a cycloalkyl group, and if R<2> is a hydrogen atom, their salts with physiological acceptable bases and their cyclodextrin clathrates, process for producing them and their pharmaceutical use.
AU88726/91A 1990-11-09 1991-11-08 9-halogen-11beta -hydroxy prostaglandin derivative, process for producing it and its use as a medicament Ceased AU650074B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE4036140 1990-11-09
DE4036140A DE4036140A1 (en) 1990-11-09 1990-11-09 9-HALOGEN-11SS-HYDROXY-PROSTAGLANDIN DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS MEDICINAL PRODUCTS
PCT/DE1991/000881 WO1992008697A2 (en) 1990-11-09 1991-11-08 9-HALOGEN-11β-HYDROXY PROSTAGLANDIN DERIVATIVE, PROCESS FOR PRODUCING IT AND ITS USE AS A MEDICAMENT

Publications (2)

Publication Number Publication Date
AU8872691A AU8872691A (en) 1992-06-11
AU650074B2 true AU650074B2 (en) 1994-06-09

Family

ID=6418184

Family Applications (1)

Application Number Title Priority Date Filing Date
AU88726/91A Ceased AU650074B2 (en) 1990-11-09 1991-11-08 9-halogen-11beta -hydroxy prostaglandin derivative, process for producing it and its use as a medicament

Country Status (8)

Country Link
EP (1) EP0510154B1 (en)
JP (1) JPH05503713A (en)
AT (1) ATE122339T1 (en)
AU (1) AU650074B2 (en)
CA (1) CA2073462A1 (en)
DE (2) DE4036140A1 (en)
HU (1) HUT61726A (en)
WO (1) WO1992008697A2 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4229048A1 (en) * 1992-08-31 1994-03-03 Schering Ag New ester(s) of 9-chloro-prostaglandin(s) - useful in treatment of glaucoma and as diuretic agents
DE4229050A1 (en) * 1992-08-31 1994-03-03 Schering Ag New esters and amides of 9-chloro-prostaglandins - useful, e.g., in treatment of glaucoma and as diuretic agents
WO1994005631A1 (en) * 1992-08-31 1994-03-17 Schering Aktiengesellschaft 9-chloroprostaglandin esters and amides and their use in the preparation of drugs
AU687906B2 (en) * 1993-12-15 1998-03-05 Alcon Laboratories, Inc. Use of certain prostaglandin analogues to treat glaucoma and ocular hypertension
JP3579448B2 (en) * 1993-12-29 2004-10-20 大正製薬株式会社 Prostaglandin derivatives, salts thereof and uses thereof
US5807892A (en) * 1994-09-30 1998-09-15 Alcon Laboratories, Inc. Use of certain prostaglandin analogues to treat glaucoma and ocular hypertension
CA2334355C (en) * 1998-05-25 2009-01-27 Taisho Pharmaceutical Co., Ltd. Prostaglandin derivatives
CA2384718C (en) * 1999-09-10 2009-12-01 Taisho Pharmaceutical Co., Ltd. Prostaglandin derivatives

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU543797B2 (en) * 1979-12-10 1985-05-02 Schering Aktiengesellschaft Pharmaceutically active 9-chloroprostaglandins
AU8221291A (en) * 1990-07-27 1992-03-02 Schering Aktiengesellschaft Berlin Und Bergkamen Cyclopentane derivatives, process for producing them and their pharmaceutical use
AU624078B2 (en) * 1987-07-17 1992-06-04 Schering Aktiengesellschaft Berlin Und Bergkamen 9-halogen-(z)-prostaglandin derivatives, process for manufacturing them, and their use as drugs

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL87116A (en) * 1987-07-17 1993-03-15 Schering Ag 9-halogen-(z)-prostaglandin derivatives and pharmaceutical compositions containing the same
SE8703854D0 (en) * 1987-10-07 1987-10-07 Pharmacia Ab PROSTAGLAND INGREDIENTS FOR TREATMENT OF GLAUCOME OR OCULAR HYPERTENSION

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU543797B2 (en) * 1979-12-10 1985-05-02 Schering Aktiengesellschaft Pharmaceutically active 9-chloroprostaglandins
AU624078B2 (en) * 1987-07-17 1992-06-04 Schering Aktiengesellschaft Berlin Und Bergkamen 9-halogen-(z)-prostaglandin derivatives, process for manufacturing them, and their use as drugs
AU8221291A (en) * 1990-07-27 1992-03-02 Schering Aktiengesellschaft Berlin Und Bergkamen Cyclopentane derivatives, process for producing them and their pharmaceutical use

Also Published As

Publication number Publication date
DE4036140A1 (en) 1992-05-14
EP0510154B1 (en) 1995-05-10
WO1992008697A3 (en) 1992-07-23
HUT61726A (en) 1993-03-01
CA2073462A1 (en) 1992-05-10
AU8872691A (en) 1992-06-11
HU9202260D0 (en) 1992-10-28
JPH05503713A (en) 1993-06-17
ATE122339T1 (en) 1995-05-15
DE59105459D1 (en) 1995-06-14
EP0510154A1 (en) 1992-10-28
WO1992008697A2 (en) 1992-05-29

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Legal Events

Date Code Title Description
MK14 Patent ceased section 143(a) (annual fees not paid) or expired