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AU651969B2 - Process for the production of aqueous liposome suspensions containing active ingredients - Google Patents
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AU651969B2 - Process for the production of aqueous liposome suspensions containing active ingredients - Google Patents

Process for the production of aqueous liposome suspensions containing active ingredients

Info

Publication number
AU651969B2
AU651969B2 AU75933/91A AU7593391A AU651969B2 AU 651969 B2 AU651969 B2 AU 651969B2 AU 75933/91 A AU75933/91 A AU 75933/91A AU 7593391 A AU7593391 A AU 7593391A AU 651969 B2 AU651969 B2 AU 651969B2
Authority
AU
Australia
Prior art keywords
active ingredients
containing active
suspensions containing
production
aqueous phase
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU75933/91A
Other versions
AU7593391A (en
Inventor
George Rossling
Andreas Sachse
Hans-Joachim Schroter
Claudia Sprenger
Cornelia Wawretschek
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=6405285&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AU651969(B2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Schering AG filed Critical Schering AG
Publication of AU7593391A publication Critical patent/AU7593391A/en
Application granted granted Critical
Publication of AU651969B2 publication Critical patent/AU651969B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1277—Preparation processes; Proliposomes

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Cosmetics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Described is a process for the preparation of aqueous liposome suspensions containing active substances, the suspensions being prepared from a solution of a liposome-forming substance, or mixture of such substances, in a lower alcohol with a maximum of three carbon atoms and an aqueous phase, the active ingredients being dissolved or suspended in the lipid solution and/or the aqueous phase. The process is characterized in that the aqueous phase is incorporated, by mixing, in the alcoholic solution and the lower alcohol removed by vacuum distillation and, if necessary, the liposome suspension freeze-dried.
AU75933/91A 1990-04-24 1991-04-24 Process for the production of aqueous liposome suspensions containing active ingredients Ceased AU651969B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4013580 1990-04-24
DE4013580A DE4013580A1 (en) 1990-04-24 1990-04-24 METHOD FOR THE PRODUCTION OF ACTIVE AQUEOUS LIPOSOME SUSPENSIONS

Publications (2)

Publication Number Publication Date
AU7593391A AU7593391A (en) 1991-11-07
AU651969B2 true AU651969B2 (en) 1994-08-11

Family

ID=6405285

Family Applications (1)

Application Number Title Priority Date Filing Date
AU75933/91A Ceased AU651969B2 (en) 1990-04-24 1991-04-24 Process for the production of aqueous liposome suspensions containing active ingredients

Country Status (15)

Country Link
EP (1) EP0478727B1 (en)
JP (1) JPH04506814A (en)
AT (1) ATE141503T1 (en)
AU (1) AU651969B2 (en)
CA (1) CA2041075A1 (en)
DE (2) DE4013580A1 (en)
DK (1) DK0478727T3 (en)
ES (1) ES2093701T3 (en)
FI (1) FI103178B1 (en)
HU (1) HU215960B (en)
IE (1) IE911350A1 (en)
NO (1) NO303481B1 (en)
PT (1) PT97468B (en)
WO (1) WO1991016039A1 (en)
ZA (1) ZA913091B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003245160B2 (en) * 2002-06-28 2009-09-24 Arbutus Biopharma Corporation Method and apparatus for producing liposomes

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69233119T2 (en) * 1991-06-18 2004-05-13 Imarx Pharmaceutical Corp., Tucson NEW LIPOSOMAL DRUG RELEASE SYSTEMS
EP0713387B1 (en) * 1993-08-06 1998-03-04 Opperbas Holding B.V. A method for preparation of vesicles loaded with biological structures, biopolymers and/or oligomers
DE69527194T2 (en) * 1994-03-28 2003-02-06 Daiichi Pharmaceutical Co., Ltd. LIPOSOME CONTAINING AN X-RAY OR ULTRASONIC CONTRAST
US6120795A (en) * 1996-03-27 2000-09-19 Ortho Pharmaceutical Corp. Manufacture of liposomes and lipid-protein complexes by ethanolic injection and thin film evaporation
RU2134967C1 (en) * 1997-05-30 1999-08-27 Шестаков Константин Алексеевич Method of preparing microcapsulated preparations containing pyrethroid insecticides
JP2002536316A (en) * 1999-02-08 2002-10-29 アルザ・コーポレーション How to control liposome size
CN101267805A (en) 2005-07-27 2008-09-17 普洛体维生物治疗公司 System and method for making liposomes
US12491261B2 (en) 2016-10-26 2025-12-09 Acuitas Therapeutics, Inc. Lipid nanoparticle formulations
ES3054438T3 (en) 2020-07-16 2026-02-03 Acuitas Therapeutics Inc Cationic lipids for use in lipid nanoparticles
CA3242402A1 (en) 2021-12-16 2023-06-22 Acuitas Therapeutics, Inc. Lipids for use in lipid nanoparticle formulations
CN114344291B (en) * 2022-02-16 2023-09-29 中南大学湘雅医院 Application of 4-phenyl-1H-pyrrole-3-carboxylic acid in preparation of medicine for treating osteoporosis and liposome

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0349429A2 (en) * 1988-06-30 1990-01-03 Centre National De La Recherche Scientifique (Cnrs) Process for the preparation of dispersible colloidal systems of amphiphilic lipids in the form of submicronic liposomes

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3416978A1 (en) * 1983-05-12 1984-12-06 Stauffer Chemical Co., Westport, Conn. TRANSFORMATION OF EUKARYOTIC CELLS MEDIATED BY LIPOSOME
JPS607932A (en) * 1983-06-29 1985-01-16 Dai Ichi Seiyaku Co Ltd Preparation of liposome
JPH0753661B2 (en) * 1984-03-08 1995-06-07 フアレス フアーマスーチカル リサーチ エヌブイ Pro-liposome composition and method of making an aqueous dispersion of liposomes
JP2554880B2 (en) * 1987-05-07 1996-11-20 ポーラ化成工業株式会社 Skin cosmetics

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0349429A2 (en) * 1988-06-30 1990-01-03 Centre National De La Recherche Scientifique (Cnrs) Process for the preparation of dispersible colloidal systems of amphiphilic lipids in the form of submicronic liposomes

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003245160B2 (en) * 2002-06-28 2009-09-24 Arbutus Biopharma Corporation Method and apparatus for producing liposomes
AU2009212823B2 (en) * 2002-06-28 2011-09-01 Arbutus Biopharma Corporation Method and apparatus for producing liposomes

Also Published As

Publication number Publication date
NO303481B1 (en) 1998-07-20
NO915012L (en) 1991-12-18
FI103178B (en) 1999-05-14
DE59108097D1 (en) 1996-09-26
HU215960B (en) 1999-03-29
EP0478727B1 (en) 1996-08-21
ZA913091B (en) 1992-12-30
EP0478727A1 (en) 1992-04-08
HU9200235D0 (en) 1992-04-28
JPH04506814A (en) 1992-11-26
PT97468A (en) 1992-01-31
CA2041075A1 (en) 1991-10-25
DK0478727T3 (en) 1997-01-20
FI916120A0 (en) 1991-12-23
WO1991016039A1 (en) 1991-10-31
NO915012D0 (en) 1991-12-18
FI103178B1 (en) 1999-05-14
ES2093701T3 (en) 1997-01-01
ATE141503T1 (en) 1996-09-15
DE4013580A1 (en) 1991-10-31
AU7593391A (en) 1991-11-07
IE911350A1 (en) 1991-11-06
PT97468B (en) 1999-12-31
HUT62457A (en) 1993-05-28

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