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AU653210B2 - Long-acting biodegradable microparticles and a process for their preparation - Google Patents
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AU653210B2 - Long-acting biodegradable microparticles and a process for their preparation - Google Patents

Long-acting biodegradable microparticles and a process for their preparation

Info

Publication number
AU653210B2
AU653210B2 AU13109/92A AU1310992A AU653210B2 AU 653210 B2 AU653210 B2 AU 653210B2 AU 13109/92 A AU13109/92 A AU 13109/92A AU 1310992 A AU1310992 A AU 1310992A AU 653210 B2 AU653210 B2 AU 653210B2
Authority
AU
Australia
Prior art keywords
long
preparation
biodegradable microparticles
acting
acting biodegradable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
AU13109/92A
Other versions
AU1310992A (en
Inventor
Norbert Lill
Jurgen Sandow
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Publication of AU1310992A publication Critical patent/AU1310992A/en
Application granted granted Critical
Publication of AU653210B2 publication Critical patent/AU653210B2/en
Anticipated expiration legal-status Critical
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Materials For Medical Uses (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)

Abstract

Long-acting biodegradable microparticles containing therapeutically active peptides as active ingredient and poly(lactide-co-glycolide) as vehicle, which are obtained by spray drying at temperatures below 60 DEG C with a spray flow above 500 l(STP), are described.
AU13109/92A 1991-03-25 1992-03-24 Long-acting biodegradable microparticles and a process for their preparation Expired AU653210B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4109746 1991-03-25
DE4109746 1991-03-25

Publications (2)

Publication Number Publication Date
AU1310992A AU1310992A (en) 1992-10-01
AU653210B2 true AU653210B2 (en) 1994-09-22

Family

ID=6428150

Family Applications (1)

Application Number Title Priority Date Filing Date
AU13109/92A Expired AU653210B2 (en) 1991-03-25 1992-03-24 Long-acting biodegradable microparticles and a process for their preparation

Country Status (20)

Country Link
EP (1) EP0505966B1 (en)
JP (1) JP3346789B2 (en)
KR (1) KR100203253B1 (en)
AT (1) ATE124254T1 (en)
AU (1) AU653210B2 (en)
CA (1) CA2063883C (en)
CY (1) CY2032A (en)
CZ (1) CZ284756B6 (en)
DE (1) DE59202649D1 (en)
DK (1) DK0505966T3 (en)
ES (1) ES2076592T3 (en)
FI (1) FI99084C (en)
HR (1) HRP940838B1 (en)
IE (1) IE67555B1 (en)
IL (1) IL101346A0 (en)
MY (1) MY109719A (en)
NO (1) NO302856B1 (en)
NZ (1) NZ242073A (en)
YU (1) YU48420B (en)
ZA (1) ZA922130B (en)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0535937B2 (en) * 1991-10-01 2008-05-21 Takeda Chemical Industries, Ltd. Prolonged release microparticle preparation and production of the same
JP2651320B2 (en) * 1992-07-16 1997-09-10 田辺製薬株式会社 Method for producing sustained-release microsphere preparation
AU4198793A (en) * 1992-07-24 1994-01-27 Takeda Chemical Industries Ltd. Microparticle preparation and production thereof
EP0625069B1 (en) * 1992-10-26 1998-12-30 Schwarz Pharma Ag Method of manufacturing microcapsules
GB9423419D0 (en) * 1994-11-19 1995-01-11 Andaris Ltd Preparation of hollow microcapsules
CA2192782C (en) * 1995-12-15 2008-10-14 Nobuyuki Takechi Production of microspheres
CA2192773C (en) 1995-12-15 2008-09-23 Hiroaki Okada Production of sustained-release preparation for injection
KR100321854B1 (en) * 1998-12-30 2002-08-28 동국제약 주식회사 Long-term sustained-release microspheres containing luteinizing hormone releasing hormone homologues and a method of producing the same
EP1389468A4 (en) 2001-05-23 2007-01-10 Tanabe Seiyaku Co COMPOSITIONS PROMOTING THE GUISON OF A BONE FRACTURE
CN1537018A (en) 2001-05-23 2004-10-13 田边制药株式会社 A composition for regenerative treatment of cartilage diseases
KR101041767B1 (en) * 2002-06-25 2011-06-17 다케다 야쿠힌 고교 가부시키가이샤 Process for preparing sustained release composition
EP1734938B1 (en) 2004-03-26 2012-06-20 Universita' Degli Studi Di Parma Insulin highly respirable microparticles
KR100722607B1 (en) * 2006-05-11 2007-05-28 주식회사 펩트론 Method for producing sustained-release microspheres with improved dispersibility and injection dose
FR2934856B1 (en) * 2008-08-05 2010-08-13 Servier Lab NEW PROCESS FOR OBTAINING THE V-CRYSTALLINE FORM OF AGOMELATIN
BR102012011209A2 (en) * 2012-05-11 2014-03-25 Bioactive Biomateriais Ltda BIODEGRADABLE THREE-DIMENSIONAL MATERIAL AND BIODEGRADABLE THREE-DIMENSIONAL MATERIAL PREPARATION PROCESS
CN105963257B (en) * 2016-04-26 2021-01-22 广州帝奇医药技术有限公司 Preparation method of sustained-release particles
CN105963258B (en) * 2016-04-26 2021-01-22 广州帝奇医药技术有限公司 A kind of preparation method of slow-release microparticles
CN109985585A (en) * 2019-05-13 2019-07-09 苏州岸谷纳米技术有限公司 A kind of fast preparation method of Biodegradable high molecular microballoon

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU600089B2 (en) * 1987-02-12 1990-08-02 Hoechst Aktiengesellschaft Multi-component long-acting medicament formulation for implantation
US4962091A (en) * 1986-05-23 1990-10-09 Syntex (U.S.A.) Inc. Controlled release of macromolecular polypeptides
AU611944B2 (en) * 1987-09-21 1991-06-27 Debio Recherche Pharmaceutique S.A. Water insoluble polypeptides

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ221411A (en) * 1986-08-11 1989-10-27 Innovata Biomed Ltd Pharmaceutical compositions containing microcapsules and a surfactant
DE3738228A1 (en) * 1987-11-11 1989-05-24 Hoechst Ag METHOD FOR PRODUCING BIODEGRADABLE MICRO-CAPSULES OF WATER-SOLUBLE PEPTIDES AND PROTEINS AND MICRO-CAPSULES OBTAINED BY THIS PROCESS
HU221294B1 (en) * 1989-07-07 2002-09-28 Novartis Ag Process for producing retarde compositions containing the active ingredient in a polymeric carrier

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4962091A (en) * 1986-05-23 1990-10-09 Syntex (U.S.A.) Inc. Controlled release of macromolecular polypeptides
AU600089B2 (en) * 1987-02-12 1990-08-02 Hoechst Aktiengesellschaft Multi-component long-acting medicament formulation for implantation
AU611944B2 (en) * 1987-09-21 1991-06-27 Debio Recherche Pharmaceutique S.A. Water insoluble polypeptides

Also Published As

Publication number Publication date
KR100203253B1 (en) 1999-06-15
ES2076592T3 (en) 1995-11-01
FI921248L (en) 1992-09-26
IE67555B1 (en) 1996-04-17
JPH0570363A (en) 1993-03-23
AU1310992A (en) 1992-10-01
CZ284756B6 (en) 1999-02-17
JP3346789B2 (en) 2002-11-18
CA2063883C (en) 2001-12-11
NZ242073A (en) 1993-08-26
MY109719A (en) 1997-05-31
EP0505966A1 (en) 1992-09-30
NO921147L (en) 1992-09-28
EP0505966B1 (en) 1995-06-28
CY2032A (en) 1998-02-20
HRP940838A2 (en) 1997-06-30
IL101346A0 (en) 1992-11-15
NO921147D0 (en) 1992-03-24
HRP940838B1 (en) 2000-12-31
DE59202649D1 (en) 1995-08-03
ATE124254T1 (en) 1995-07-15
CA2063883A1 (en) 1992-09-26
YU48420B (en) 1998-07-10
FI921248A0 (en) 1992-03-23
NO302856B1 (en) 1998-05-04
DK0505966T3 (en) 1995-10-30
CS88792A3 (en) 1992-10-14
FI99084B (en) 1997-06-30
YU26392A (en) 1994-12-28
FI99084C (en) 1997-10-10
IE920956A1 (en) 1992-10-07
ZA922130B (en) 1992-11-25
KR920017645A (en) 1992-10-21

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