AU673742B2 - Composition for reducing hair loss or stimulating hair growth - Google Patents

Abstract

Composition for enhancing hair growth or stopping hair loss, containing, in a hydroalcohol or aqueous medium comprising water and an alkylene glycol or polyalkylene glycol liquid at room temperature: a) at least 0.03 to 0.3 weight percent of fructose; b) at least 0.002 to 0.05 weight percent of glucose; c) at least 0.03 to 0.2 weight percent of one or more cereal spheroproteins or their hydrolysates; d) at least 0.03 to 1 weight percent of a sodium or potassium salt.

Description

I 3I~ RIPIII 1 Composition based on fructose, glucose and cereal globular proteins or their hydrolysates, for decreasing hair loss and/or promoting hair regrowth The invention relates to compositions intended for promoting hair regrowth and/or decreasing hair loss, based on fructose, glucose and cereal globular proteins or their hydrolysates.

A person skilled in the art has known for a long time that natural hair loss in man reflects overall the balance of the hair follicles between the alternating phases of growth (anagen) and phases of loss (telogen) The average ratio of the number of follicles in the anagen phase to that in the telogen phase is of the order of 9 (90:10). It is apparent from this that the percentage of follicles in the rest phase (catagen) is very small.

The "natural loss or shedding of hair may be estimated at a few hundred hairs per day for the normal physiological state.

It is known, moreover, that certain factors such as a hormonal imbalance, a physiological stress or malnutrition can intensify the phenomenon.

In some dermatoses of the scalp in which inflammation is a feature, such as, for example, psoriasis or seborrhoeic dermatitis, hair loss may be strongly intensified or may give rise to greatly disturbed follicle cycles.

Surprisingly, the Applicant has discovered compositions based on fructose, glucose and cereal globular proteins or their hydrolysates that enable the survival of the hair follicle during the anagen phase to be prolonged.

The Applicant discovered that these compositions were especially effective for restoring hair and/or for halting hair loss, in particular in the treatment of disorders of the scalp such as pelade, hair loss, desquamating dermatitis and alopecia.

According to an especially preferred embodiment, r 2 it was established that the use of a hydrating agent in these compositions enabled their efficacy to be improved.

The subject of the invention is hence a new composition for decreasing hair loss and/or for promoting hair regrowth.

Another subject of the invention consists of its application to the treatment of the scalp and hair.

A subject of the invention also consists of the use of the compositions as defined above for the preparation of a medicinal product intended for the treatment of disorders of the scalp such as hair loss, desquamating dermatitis, alopecia and pelade.

Lastly, the subject of the invention is a process for the cosmetic treatment of hair, consisting in applying at least one of the compositions as defined above to the scalp or hair and then, where appropriate, in rinsing the latter with water; the composition essentially having; f6r'-this purpose, an effect of improving the appearance of the head of hair.

Other subjects of the invention will become apparent on reading the description and the examples which follow.

The composition according to the invention is essentially characterized in that it contains, in an aqueous or aqueous-alcoholic medium comprising water and from 0.01 to 0.5 by weight of a alkylene glycol or of a C 2

-C

4 polyalkylene glycol which is liquid at room temperature: a) at least from 0.03 to 0.3 by weight of fructose; b) at least from 0.002 to 0.05 by weight of glucose; c) at least from 0.03 to 0.2 by weight of one or more cereal globular proteins or their hydrolysates; d) at least from 0.03 to 1 by weight of a sodium or potassium salt; the weight percentages being defined relative to the total weight of the composition.

An especially preferred form of composition 1 I A 3 according to the invention consists of a formulation as is defined above containing, in addition, a hydrating agent chosen from urea and a C 3 polyol such as sorbitol or glycerol. The hydrating agent is used in proportions preferably of between 0.005 and 0.5 by weight relative to the total weight of the composition. More especially, urea is used.

Preferred compositions according to the invention contain an organic acid such as lactic acid or citric acid. The final pH of the composition has a value of between 6.5 and 8, and is adjusted with any acidifying and/or alkalinizing agent. More especially, lactic acid is used, for example in concentrations of between 2 x 10-4 and 1 by weight.

The cereal globular proteins used according to the present invention are chosen, in particular, from the globular proteins of wheat, maize, barley, oats, rice and millet: These cereal proteins consist, in particular, of a mixture of prolamine and glutenin.

The prolamine of wheat is gliadin; that of barley is hordein; that of oats, avenin; that of maize, zein; that of rice, orizin; and that of millet, kafirin.

These globular proteins consist mainly of glutamic acid, proline and a small amount of lysine.

The molecular weight of the cereal globular proteins used according to the invention is preferably greater than 20,000.

The molecular weight of the hydrolysates of these proteins is preferably less than 20,000.

The proteins or protein hydrolysates of the invention are preferably used in amounts of between 0.05 and 0.15 by weight.

More especially, wheat globular proteins of molecular weight greater than 30,000 and whose level of protein purity is greater than 90 are used.

The solvents used in the aqueous or aqueousalcoholic medium of the compositions of the invention are chosen, in particular, from polyethylene glycols, in particular polyethylene glycols 300, 400 and. 600, 4 propylene glycol, hexylene glycol and dipropylene glycol.

The alcohols used in the aqueous-alcoholic compositions are C 2 alcohols, in particular ethanol and propanol. They are present in amounts of from 25 to 50 by weight relative to the weight of the water/alcohol mixture.

The salts present in the compositions of the invention are chosen in particular, from sodium chloride and potassium chloride, and more especially sodium chloride. They are preferably used in amounts of between 0.1 and 0.5 by weight.

Fructose and glucose are preferably used in proportions of between 0.05 and 0.2 by weight and between 0.01 and 0.03 by weight, respectively.

The compositions according to the invention may be presented in various dosage forms customarily used in pharmacy or in cosmetics for treatment of the scalp.

They take the form, in particular, of a lotion, thickened or otherwise, which is used in rinsed or unrinsed treatment; gel; rinsed milk or cream; mousse or spray with a directional nozzle.

These compositions can contain thickeners such as cellulose or cellulose derivatives, for instance hydroxyethylcellulose; heterobiopolysaccharides such as xanthan gum; guar gum; polyacrylic acids crosslinked with a polyfunctional agent, such as the products sold under che name CARBOPOL, or crosslinked polymers or copolymers of acrylamide.

These compositions can optionally contain other adjuvants customarily used in cosmetics or in pharmacy, in particular for the scalp, such as surfactants, perfumes, preservatives, colorants, cationic, nonionic, anionic or amphoteric polymers, propellants, foam stabilizers, trace elements, anti-dandruff agents, soothing agents, antibacterial agents, scalp-stimulating agents such as vitamins, for instance calcium pantothenate and anti-grease agents.

The examples which follow serve to illustrate the invention without, however, being limiting in nature.

5 EXAMPLE 1 LOTION FOR COMBATTING HAIR LOSS Wheat protein Fructose Glucose Urea NaCl Polyethylene glycol Lactic acid Potassium hydroxide qs pH Water/eth:yl alcohol at a concentration of 31 by weight EXAMPLE 2 THICKENED LOTION FOR COMBATTING HAIR LOSS Wheat protein Fructose Glucose Urea NaC1 Propylene glycol Lactic acid Potassium hydroxide qs pH Guar gum sold under the name "JAGUAR HP8" by the company MEYHALL Water/ethyl alcohol at a concentration of 31 by weight 0.12 g 0.22 g 0.04 g 0.06 g 0.5 g 0.25 g 0.05 g qs 100 g 0.09 0.15 0.02 0.03 0.3 0.15 0.01 0.4 g qs 100 g

Claims (15)

1. Composition intended for promoting hair regrowth and/or halting hair loss, characterized in that it contains, in an aqueous or aqueous-alcoholic medium comprising water and from 0.01 to 0.5 by weight of a C 3 alkylene glycol or of a C 2 -C 4 polyalkylene glycol which is liquid at room temperature: a) at least from 0.03 to 0.3 by weight of fructose; b) at least from 0.002 to 0.05 by weight of glucose; c) at least from 0.03 to 0.2 by weight of one or more cereal globular proteins or their hydrolysates; d) at least from 0.03 to 1 by weight of a sodium or potassium salt; the weight percentages being defined relative to the total weight of the composition.

2. Composition according to Claim 1, characterized in that it contains, in addition, a hydrating agent chosen from urea and a C 3 -C 6 polyol.

3. Composition according to Claim 1 or 2, character- ized in that it contains, in addition, an organic acid.

4. Composition according to Claim 2, characterized in that the hydrating agent is present in proportions of betwen 0.005 and 0.5 by weight. Composition according to Claim 2 or 4, character- ized in that the hydrating agent is urea.

6. Composition according to Claim 3, characterized in that the organic acid is lactic or citric acid.

7. Composition according to any one of Claims 1 to 6, characterized in that the cereal globular proteins or their hydrolysates are chosen from the globular proteins of wheat, maize, cats, barley, rice or millet, or their hydrolysates.

8. Composition according to Claim 7, characterized in that the globular proteins have a molecular weight of greater than 20,000, and their hydrolysates have a molecular weight of less than 20,000.

9. Composition according to any one of Claims 1 to 7 8, characterized in that it contains wheat globular proteins of molecular weight greater than 30,000. Composition according to any one of Claims 1 to 9, characterized in that the aqueous or aqueous-alcoholic medium contains a solvent chosen from polyethylene glycol, propylene glycol, hexylene glycol and dipropylene glycol.

11. Composition according to any one of Claims 1 to characterized in that the aqueous-alcoholic medium contains from 25 to 50 by weight of alcohol relative to the total weight of the said medium.

12. Composition according to any one of Claims 1 to characterized in that the sodium or potassium salt is sodium or potassium chloride.

13. Composition according to any one of Claims 1 to 12, characterized in that it contains: a) from 0.05 to 0.2 by weight of fructose; from 0.01 to 0.03 by weight of glucose; c) from 0.05 to 0.15 by weight of cereal proteins or of hydrolysate of globular protein; d) from 0.1 to 0.5 by weight of sodium salt or potassium salt.

14. Composition according to any one of Claims 1 to 13, characterized in that it takes the form of a lotion, thickened or otherwise, gel, rinsed milk or cream, mousse or spray with a directional nozzle. Composition according to any one of Claims 1 to 14, characterized in that it contains, in addition, thickeners, surfactants, preservatives, perfumes, colorants, foam stabilizers, propellants, cationic, anionic, nonionic or amphoteric polymers, trace elements, anti-dandruff agents, soothing agents, antibacterial agents, scalp-stimulating agents or anti-grease agents.

16. Process for the cosmetic treatment of hair, characterized in that a composition according to any one of Claims 1 to 15 is applied to the scalp or hair; the said application being followed, where appropriate, by a rinse with water.

17. Use of a composition according to any one of 8 claims 1 to 15, for the treatment of hair eI-. pelade, desquamating dermatitis or alopecia. DATED this 18th ay of September, 1996. L'OREAL WATERMARK PATENT TRADEMARK ATTORNEYS 290 BURWOOD ROAD HAWTHORN VICTORIA 3122 AUSTRALIA SKP:PAK:JL VAX DOC 08 AU6724394 WPC o• S. oe 9 93/872 LM/DD ABSTRACT FR 642 Composition based on fructose, glucose and cereal globular proteins or their hydrolysates, for decreasing hair loss and/or promoting hair regrowth The invention relates to a composition intended for promoting hair regrowth or halting hair loss, con- taining, in an aqueous or aqueous-alcoholic medium comprising water and an alkylene glycol or a polyalkylene glycol which is liquid at room temperature: a) at least from 0.03 to 0.3 by weight of fructose; b) at least from 0.002 to 0.05 by weight of glucose; c) at least from 0.03 to 0.2 by weight of one or more cereal globular proteins or their hydrolysates; at least from 0.03 to 1 by weight of a sodium or potassium salt. INTERNATIONAL SEARCH REPORT n, onIl Applicaton No PCT/FR 94/00527 A. CLASSIFICATION OF SUBJECT MATTER IPC 5 A61K7/06 According to Internatonal Patent Classification (IPC) or to both national classification and [PC B. FIELDS SEARCHED Minimum documentation searched (classification system followed by classification symbols) IPC 5 A61K Documentation searched other than minmum documentation to the extent that such documents are included in the fields searched Electronic data base consulted during the international search (name of data base and, where practical, search terms used) C. DOCUMENTS CONSIDERED TO BE RELEVANT Category Citation of document, with indication, where appropnate, of the relevant passages Relevant to claim No. X US,A,2 383 990 SVERRE QUISLING) 4 1-3,6,7, September 1945 12,14-16 see the whole document A WO,A,92 17153 (HENKEL 1-17 KOMMANDITGESELLSCHAFT) 15 October 1992 see the whole document A EP,A,0 383 467 J. STRYDOM) 22 August 1-17 1990 see the whole document A WO,A,92 21318 (GIVAUDAN-LAVIROTTE) 10 1-17 December 1992 ae the whole document rv Further documents are listed in the continuation of box C. Y Patent family members are listed in annex. SSpecial categones of cited documents 'T later document published after the international filing date or priority date and not in conflict with the application but document defining the general state of the art which is not cited to understand the pnnciple or theory underlying the considered to be of particular relevance invention earlier document but published on or after the international document of particular relevance; the claimed invention filing date cannot be considered novel or cannot be considered to document which may throw doubts on priority claim(s) or involve an inventive step when the document is taken alone which Is cited to establish the publication date of another document of particular relevance; the claimed invention citation or other special reason (as specified) cannot be consir'red to involve an inventive step when the document referring to an oral disclosure, use, exhibition or document is conr., ned with one or more other such docu- other means ments, such combination being obvious to a person skilled document published prior to the international filing date but in the art. later than the priority date claimed document member of the same patent family Date of the actual completion of the international search Date of mailing of the international search report 02.08.94 July 1994 Name and mailing address of the ISA Authorized officer European Patent Office, P.B. 5818 Patentlaan 2 NL 2280 HV Rijswijk Tel. (+31-70) 340-2040,Tx. 31651 cpon, Sierra Gonzalez, M Fax

31-70) 340-3016 Form PCT/ISA/210 (second sheet) (July 1992) page 1 of 2 INTERNATriONAL SEARCH REPORT Int, U1nna ApplICAt)on NO POT/FR 94/00527 C.(Conflnuatton) DOCUMENT'S CONSIDERED TO HE RELEVANT Category Citation of docment, with tadicat:;nr. where appropnate, of the relevant passages [Rlvn ocamNo. FR,A,2 609 393 (LABORATORIES SEROBIOLOGIQUES) 15 July 1988 see the whole document 1-17 I _I __I Form PCT/ISA/210 (continuution of £econd Sheet) (July 1992) page 2 of 2 INTE~RNATIONAL 81rAICII ILIPW'RTp~IcamN lnrormitton on pAtent family inriir fPCI /FR 94/00527 Patent document Pu Laion IPatent family I Publication cited in search report daemember(s) date US-A-2383990 NONE WO-A-9217153 15-10-92 DE-A- 4109999 01-10-92 CA-A- 2107120 28-09-92 EP-A- 0577636 12-01-94 EP-A-0383467 22-08-90 AU-A- 4918790 09-08-90 CA-A- 2009204 06-08-90 WO--9221318 10-12-92 FR-A- 2676922 04-12-92 CA-A- 2110593 10-12-92 EP-A- 0586501 16-03-94 FR-A-2609393 15-07-88 FR-A- 2627385 25-08-89 Form PCT/ISA/210 ipatemt family ane) (July 1992)