AU675433B2 - Benzimidazoles - Google Patents

Benzimidazoles

Info

Publication number: AU675433B2
Authority: AU; Australia
Prior art keywords: benzimidazoles
Prior art date: 1991-02-06
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Application number

AU42094/93A

Other versions

AU4209493A (en

Inventor

Michael Entzeroth

Norbert Hauel

Uwe Ries

Jacques Van Meel

Wolfgang Wienen

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Boehringer Ingelheim Pharma GmbH and Co KG

Original Assignee

Dr Karl Thomae GmbH

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-02-06

Filing date

1993-07-21

Publication date

1997-02-06

1993-07-21 Application filed by Dr Karl Thomae GmbH filed Critical Dr Karl Thomae GmbH

1994-01-27 Publication of AU4209493A publication Critical patent/AU4209493A/en

1997-02-06 Application granted granted Critical

1997-02-06 Publication of AU675433B2 publication Critical patent/AU675433B2/en

2012-02-05 Anticipated expiration legal-status Critical

Status Expired legal-status Critical Current

Links

150000001556 benzimidazoles Chemical class 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D235/08—Radicals containing only hydrogen and carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Ophthalmology & Optometry (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

AU42094/93A 1991-02-06 1993-07-21 Benzimidazoles Expired AU675433B2 (en)

Applications Claiming Priority (5)

Application Number	Priority Date	Filing Date	Title
DE4103492		1991-02-06
DE4117121		1991-05-25
DE4137812		1991-11-16
DE4224133		1992-07-22
DE4224133A DE4224133A1 (en)	1992-07-22	1992-07-22	Benzimidazoles, medicaments containing these compounds and process for their preparation

Related Parent Applications (2)

Application Number	Title	Priority Date	Filing Date
AU10707/92A Addition AU655794C (en)	1991-02-06	1992-02-05	Benzimidazole compounds
AU10707/92A Division AU655794C (en)	1991-02-06	1992-02-05	Benzimidazole compounds

Publications (2)

Publication Number	Publication Date
AU4209493A AU4209493A (en)	1994-01-27
AU675433B2 true AU675433B2 (en)	1997-02-06

Family

ID=6463804

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AU42094/93A Expired AU675433B2 (en)	1991-02-06	1993-07-21	Benzimidazoles

Country Status (20)

Country	Link
EP (1)	EP0581166A1 (en)
JP (1)	JPH06179659A (en)
KR (1)	KR940005584A (en)
CN (1)	CN1050122C (en)
AU (1)	AU675433B2 (en)
CA (1)	CA2100927A1 (en)
CZ (1)	CZ144993A3 (en)
DE (1)	DE4224133A1 (en)
FI (1)	FI933284A7 (en)
HU (1)	HUT64955A (en)
IL (1)	IL106408A (en)
MX (1)	MX9304424A (en)
NO (1)	NO300772B1 (en)
NZ (1)	NZ248217A (en)
PL (1)	PL172929B1 (en)
RU (1)	RU2126401C1 (en)
SG (1)	SG43083A1 (en)
SK (1)	SK73293A3 (en)
TW (1)	TW229207B (en)
ZA (1)	ZA93529B (en)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE4233590A1 (en) *	1992-10-06	1994-04-07	Thomae Gmbh Dr K	Benzimidazoles, medicaments containing these compounds and process for their preparation
DE4304455A1 (en) *	1993-02-15	1994-08-18	Bayer Ag	Heterocyclic substituted phenyl-cyclohexane-carboxylic acid derivatives
DE4324580A1 (en) *	1993-07-22	1995-01-26	Thomae Gmbh Dr K	Bicyclic heterocycles, pharmaceutical compositions containing them and methods for their preparation
DE19503160A1 (en) *	1995-02-01	1996-08-08	Bayer Ag	Use of phenylcyclohexylcarboxylic acid amides
WO1997024334A1 (en) *	1995-12-28	1997-07-10	Fujisawa Pharmaceutical Co., Ltd.	Benzimidazole derivatives
TW453999B (en) *	1997-06-27	2001-09-11	Fujisawa Pharmaceutical Co	Benzimidazole derivatives
RU2185171C2 (en) *	1999-06-25	2002-07-20	Институт нефтехимии и катализа АН РБ и УНЦ РАН	Method for prophylaxis of reocclusions in case of operations conducted upon the main vessels
HU222773B1 (en) *	2000-04-21	2003-10-28	Richter Gedeon Vegyészeti Gyár Rt.	Process for producing a known tetrazole derivative
JPWO2005011736A1 (en) *	2003-07-30	2006-09-14	株式会社東北テクノアーチ	Preventive and / or therapeutic agent for Alzheimer's disease
DE102004060699A1 (en) *	2004-12-16	2006-06-22	Ratiopharm Gmbh	Process for the preparation of candesartan
RU2427574C2 (en) *	2009-07-16	2011-08-27	Государственное образовательное учреждение высшего профессионального образования "Астраханский государственный университет" (АГУ)	Monohydrochlorides and sodium salts of tautomeric 5 (6)-alkoxycarbonylamino-derivatives of 2-aryl-1-hydroxybenzimidazole-3-oxide with high antifungal activity and synthesis method thereof
CN101921265B (en) *	2009-11-25	2012-07-04	北京理工大学	Biphenylacylamine tetrazole compounds, synthetic method and application
CN101891735B (en) *	2009-11-25	2012-07-18	北京理工大学	Biphenyl sulfafurazole compound, synthesis method and application thereof
MX2014005285A (en) *	2011-11-03	2014-05-30	Hoffmann La Roche	Bicyclic piperazine compounds.
CN105820125B (en) *	2015-01-09	2018-12-07	北京中医药大学	A kind of compound and its preparation method and application for treating hypertension
CN105384729B (en) *	2015-07-09	2019-02-19	天津青松华药医药有限公司	Telmisartan ester derivative and the preparation method and application thereof
CN106749220B (en) *	2017-01-18	2019-08-06	东华大学	6 '-substituted benzimidazole -4- substituent methyl indole derivatives of one kind and its preparation and application

Citations (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU5301390A (en) *	1989-04-08	1990-10-11	Dr. Karl Thomae Gmbh	Benzimidazoles
AU8122791A (en) *	1990-07-23	1992-01-30	Dr. Karl Thomae Gmbh	Benzimidazoles
AU4123793A (en) *	1992-06-13	1993-12-23	Merck Patent Gmbh	Benzimidazole derivatives

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPH05504969A (en) *	1990-02-13	1993-07-29	メルク・エンド・カムパニー・インコーポレーテツド	Angiotensin 2 antagonists containing substituted benzyl elements
SI9210098B (en) *	1991-02-06	2000-06-30	Dr. Karl Thomae	Benzimidazoles, drugs with this compounds, and process for their preparation

1992
- 1992-07-22 DE DE4224133A patent/DE4224133A1/en not_active Withdrawn
1993
- 1993-06-12 TW TW082104675A patent/TW229207B/zh active
- 1993-07-12 SK SK732-93A patent/SK73293A3/en unknown
- 1993-07-20 EP EP93111581A patent/EP0581166A1/en not_active Ceased
- 1993-07-20 IL IL10640893A patent/IL106408A/en not_active IP Right Cessation
- 1993-07-20 SG SG1996003403A patent/SG43083A1/en unknown
- 1993-07-20 CN CN93108085A patent/CN1050122C/en not_active Expired - Fee Related
- 1993-07-20 CA CA002100927A patent/CA2100927A1/en not_active Abandoned
- 1993-07-20 CZ CZ931449A patent/CZ144993A3/en unknown
- 1993-07-21 AU AU42094/93A patent/AU675433B2/en not_active Expired
- 1993-07-21 KR KR1019930013764A patent/KR940005584A/en not_active Ceased
- 1993-07-21 HU HU9302115A patent/HUT64955A/en unknown
- 1993-07-21 FI FI933284A patent/FI933284A7/en unknown
- 1993-07-21 PL PL93299754A patent/PL172929B1/en unknown
- 1993-07-21 ZA ZA93529A patent/ZA93529B/en unknown
- 1993-07-21 NZ NZ248217A patent/NZ248217A/en unknown
- 1993-07-21 JP JP5179485A patent/JPH06179659A/en active Pending
- 1993-07-21 NO NO932636A patent/NO300772B1/en not_active IP Right Cessation
- 1993-07-22 MX MX9304424A patent/MX9304424A/en unknown
- 1993-07-22 RU RU93049407A patent/RU2126401C1/en active

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU5301390A (en) *	1989-04-08	1990-10-11	Dr. Karl Thomae Gmbh	Benzimidazoles
AU8122791A (en) *	1990-07-23	1992-01-30	Dr. Karl Thomae Gmbh	Benzimidazoles
AU4123793A (en) *	1992-06-13	1993-12-23	Merck Patent Gmbh	Benzimidazole derivatives

Also Published As

Publication number	Publication date
PL299754A1 (en)	1994-03-21
EP0581166A1 (en)	1994-02-02
CZ144993A3 (en)	1994-03-16
IL106408A0 (en)	1993-11-15
HUT64955A (en)	1994-03-28
NO932636L (en)	1994-01-24
PL172929B1 (en)	1997-12-31
KR940005584A (en)	1994-03-21
NZ248217A (en)	1996-06-25
RU2126401C1 (en)	1999-02-20
CN1083812A (en)	1994-03-16
HU9302115D0 (en)	1993-10-28
NO300772B1 (en)	1997-07-21
SK73293A3 (en)	1994-04-06
TW229207B (en)	1994-09-01
IL106408A (en)	1998-08-16
MX9304424A (en)	1994-01-31
FI933284A0 (en)	1993-07-21
CA2100927A1 (en)	1994-01-23
JPH06179659A (en)	1994-06-28
CN1050122C (en)	2000-03-08
DE4224133A1 (en)	1994-01-27
NO932636D0 (en)	1993-07-21
ZA93529B (en)	1995-01-23
FI933284A7 (en)	1994-01-23
AU4209493A (en)	1994-01-27
SG43083A1 (en)	1997-10-17

Legal Events

Date	Code	Title	Description
2000-04-13	NCW	Application for extension of term withdrawn (under section 73 patents act 1990)	Free format text: PRODUCT NAME: MICARDIS TELMISARTAN

Publication	Publication Date	Title
AU6018194A (en)	1995-08-01	Easy intubator
AU655472B2 (en)	1994-12-22	Imidazodiazepines
AU653847B2 (en)	1994-10-13	Benzodioxanderivate
AU4123793A (en)	1993-12-23	Benzimidazole derivatives
AU1782292A (en)	1992-10-21	Gridbeam
AU675433B2 (en)	1997-02-06	Benzimidazoles
AU654362B2 (en)	1994-11-03	Pyrrolopyrazines
AU2636292A (en)	1993-04-22	Anti-alpha6-integrin-antibodies
AU2135292A (en)	1993-03-04	Cyanophenylpyrroles
AU1556892A (en)	1992-09-15	2-substituted-2-imidazolines
AU3679693A (en)	1993-10-14	Benzimidazoles
AU1080292A (en)	1992-08-13	Ige-receptor-antibodies
AU1033992A (en)	1992-08-06	3-quinuclidine derivatives
AU2586192A (en)	1993-05-03	Imaginograph
AU1752492A (en)	1992-11-17	Diamino-alpha-alkylstilbenes
AU3018192A (en)	1993-06-24	Sulfonimidamides
AU647640B2 (en)	1994-03-24	Quinolin-2-yl-methoxybenzylhydroxyureas
AU1732692A (en)	1992-12-10	Substituted imidazolinylpyrimidines
AU2979992A (en)	1993-06-10	Quinolylmethoxyphenyl-acetamides
AU2279992A (en)	1993-02-23	Benzimidazoles
AU1153892A (en)	1992-09-07	Pyrimidinyl- and triazinylsalicyl- and -picolinylaldehyde derivatives
AU1624092A (en)	1992-11-19	Mopheads
AU2521192A (en)	1993-03-25	Polyolefin-polyamine-N-substituted poly-carbamates
AU1669792A (en)	1992-11-17	Azabicycloheptanone
AU1588892A (en)	1992-11-02	Watch-strap