Deprecated: The each() function is deprecated. This message will be suppressed on further calls in /home/zhenxiangba/zhenxiangba.com/public_html/phproxy-improved-master/index.php on line 456
AU690588B2 - Novel pyrazine carboxamide derivatives, their production and their use in medicaments - Google Patents
[go: Go Back, main page]

AU690588B2 - Novel pyrazine carboxamide derivatives, their production and their use in medicaments - Google Patents

Novel pyrazine carboxamide derivatives, their production and their use in medicaments

Info

Publication number
AU690588B2
AU690588B2 AU79936/94A AU7993694A AU690588B2 AU 690588 B2 AU690588 B2 AU 690588B2 AU 79936/94 A AU79936/94 A AU 79936/94A AU 7993694 A AU7993694 A AU 7993694A AU 690588 B2 AU690588 B2 AU 690588B2
Authority
AU
Australia
Prior art keywords
medicaments
production
carboxamide derivatives
pyrazine carboxamide
novel pyrazine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU79936/94A
Other versions
AU7993694A (en
Inventor
Dietrich Arndts
Wolf-Dietrich Bechtel
Walter Losel
Otto Roos
Georg Speck
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim International GmbH
Original Assignee
Boehringer Ingelheim International GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim International GmbH filed Critical Boehringer Ingelheim International GmbH
Publication of AU7993694A publication Critical patent/AU7993694A/en
Application granted granted Critical
Publication of AU690588B2 publication Critical patent/AU690588B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/10—Expectorants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

The novel compounds of formula (I), which is explained in the description, can be conventionally produced and used as medical substances.
AU79936/94A 1993-11-04 1994-10-31 Novel pyrazine carboxamide derivatives, their production and their use in medicaments Ceased AU690588B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE4337609A DE4337609A1 (en) 1993-11-04 1993-11-04 Novel pyrazinecarboxamide derivatives, their preparation and their use in medicines
DE4337609 1993-11-04
PCT/EP1994/003580 WO1995012592A1 (en) 1993-11-04 1994-10-31 Novel pyrazine carboxamide derivatives, their production and their use in medicaments

Publications (2)

Publication Number Publication Date
AU7993694A AU7993694A (en) 1995-05-23
AU690588B2 true AU690588B2 (en) 1998-04-30

Family

ID=6501757

Family Applications (1)

Application Number Title Priority Date Filing Date
AU79936/94A Ceased AU690588B2 (en) 1993-11-04 1994-10-31 Novel pyrazine carboxamide derivatives, their production and their use in medicaments

Country Status (17)

Country Link
EP (1) EP0726899B1 (en)
JP (1) JPH09505035A (en)
KR (1) KR960705815A (en)
CN (1) CN1134151A (en)
AT (1) ATE188965T1 (en)
AU (1) AU690588B2 (en)
CA (1) CA2175837A1 (en)
CO (1) CO4290432A1 (en)
DE (2) DE4337609A1 (en)
DK (1) DK0726899T3 (en)
ES (1) ES2140565T3 (en)
GR (1) GR3033034T3 (en)
NZ (1) NZ274848A (en)
PL (1) PL314187A1 (en)
PT (1) PT726899E (en)
WO (1) WO1995012592A1 (en)
ZA (1) ZA948669B (en)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19548812A1 (en) * 1995-12-27 1997-07-03 Hoechst Ag Use of inhibitors of the cellular Na · + · / H · + · exchanger (NHE) for the manufacture of a medicament for respiratory stimulation
DE19738604A1 (en) * 1997-09-04 1999-03-11 Hoechst Marion Roussel De Gmbh Use of Na<+>/H<+> exchange inhibitors
EP1182194A4 (en) 1999-06-03 2004-02-11 Takeda Chemical Industries Ltd Pernasal preparations
US6156758A (en) * 1999-09-08 2000-12-05 Isis Pharmaceuticals, Inc. Antibacterial quinazoline compounds
KR20050008691A (en) 2002-04-19 2005-01-21 셀룰러 지노믹스 아이엔씨 Imidazo[1,2-a]Pyrazin-8-ylamines Method Of Making And Method Of Use Thereof
AU2003270489A1 (en) 2002-09-09 2004-03-29 Cellular Genomics, Inc. 6-ARYL-IMIDAZO(1,2-a)PYRAZIN-8-YLAMINES, METHOD OF MAKING, AND METHOD OF USE THEREOF
WO2004072080A1 (en) 2003-02-10 2004-08-26 Cellular Genomics, Inc. Certain 8-heteroaryl-6-phenyl-imidazo[1,2-a]pyrazines as modulators of hsp90 complex activity
US7405295B2 (en) 2003-06-04 2008-07-29 Cgi Pharmaceuticals, Inc. Certain imidazo[1,2-a]pyrazin-8-ylamines and method of inhibition of Bruton's tyrosine kinase by such compounds
WO2005005429A1 (en) 2003-06-30 2005-01-20 Cellular Genomics, Inc. Certain heterocyclic substituted imidazo[1,2-a]pyrazin-8-ylamines and methods of inhibition of bruton’s tyrosine kinase by such compounds
MXPA05013905A (en) 2003-07-02 2006-02-24 Hoffmann La Roche Arylamine-substituted quinazolinone compounds.
US7259164B2 (en) 2003-08-11 2007-08-21 Cgi Pharmaceuticals, Inc. Certain substituted imidazo[1,2-a]pyrazines, as modulators of kinase activity
JP2007506787A (en) 2003-09-23 2007-03-22 バーテックス　ファーマシューティカルズ　インコーポレイテッド Pyrazolopyrrole derivatives as protein kinase inhibitors
WO2007024294A2 (en) 2005-05-03 2007-03-01 Cgi Pharmaceuticals, Inc. Certain substituted ureas, as modulators of kinase activity
WO2009102468A1 (en) 2008-02-13 2009-08-20 Cgi Pharmaceuticals, Inc. 6-aryl-imidaz0[l, 2-a] pyrazine derivatives, method of making, and method of use thereof
PL2716157T3 (en) 2008-12-08 2017-06-30 Gilead Connecticut, Inc. Imidazopyrazine Syk inhibitors
US8450321B2 (en) 2008-12-08 2013-05-28 Gilead Connecticut, Inc. 6-(1H-indazol-6-yl)-N-[4-(morpholin-4-yl)phenyl]imidazo-[1,2-A]pyrazin-8-amine, or a pharmaceutically acceptable salt thereof, as a SYK inhibitor
PE20120121A1 (en) 2008-12-08 2012-02-20 Gilead Connecticut Inc IMIDAZOPYRAZINE DERIVATIVES AS SYK INHIBITORS
AU2011226689B2 (en) 2010-03-11 2016-09-01 Kronos Bio, Inc. Imidazopyridines Syk inhibitors
EA024099B1 (en) 2010-09-13 2016-08-31 Оцука Фармасьютикал Ко., Лтд. Heterocyclic compounds for treating or preventing disorders caused by reduced neurotransmission of serotonin, norephnephrine or dopamine
KR101810798B1 (en) 2013-07-30 2017-12-19 질레드 코네티컷 인코포레이티드 Polymorph of syk inhibitors
PE20160605A1 (en) 2013-07-30 2016-07-20 Gilead Connecticut Inc SYK INHIBITOR FORMULATIONS
CN103467392B (en) * 2013-10-09 2016-08-17 重庆工商大学 A kind of polyhalo pyrazinecarboxamide derivatives and its esters, preparation method and purposes
KR20160090903A (en) 2013-12-04 2016-08-01 길리애드 사이언시즈, 인코포레이티드 Methods for treating cancers
TWI735853B (en) 2013-12-23 2021-08-11 美商克洛諾斯生技有限公司 Syk inhibitors
US9290505B2 (en) 2013-12-23 2016-03-22 Gilead Sciences, Inc. Substituted imidazo[1,2-a]pyrazines as Syk inhibitors
SG11201610551TA (en) 2014-07-14 2017-01-27 Gilead Sciences Inc Combinations for treating cancers
EP3672974A1 (en) 2017-08-25 2020-07-01 Gilead Sciences, Inc. Polymorphs of syk inhibitors
US11339168B2 (en) 2019-02-22 2022-05-24 Kronos Bio, Inc. Crystalline forms of 6-(6-aminopyrazin-2-yl)-N-(4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)imidazo[1,2-a]pyrazin-8-amine as Syk inhibitors

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3313813A (en) * 1962-10-30 1967-04-11 Merck & Co Inc (3-amino-5, 6-disubstituted-pyrazinoyl) guanidines
WO1993004048A1 (en) * 1991-08-16 1993-03-04 Boehringer Ingelheim Kg New pyrazine derivatives, their preparation and their use

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3313813A (en) * 1962-10-30 1967-04-11 Merck & Co Inc (3-amino-5, 6-disubstituted-pyrazinoyl) guanidines
WO1993004048A1 (en) * 1991-08-16 1993-03-04 Boehringer Ingelheim Kg New pyrazine derivatives, their preparation and their use

Also Published As

Publication number Publication date
CN1134151A (en) 1996-10-23
GR3033034T3 (en) 2000-08-31
EP0726899A1 (en) 1996-08-21
EP0726899B1 (en) 2000-01-19
CA2175837A1 (en) 1995-05-11
DE4337609A1 (en) 1995-05-11
DK0726899T3 (en) 2000-06-26
WO1995012592A1 (en) 1995-05-11
AU7993694A (en) 1995-05-23
ES2140565T3 (en) 2000-03-01
ATE188965T1 (en) 2000-02-15
PT726899E (en) 2000-04-28
JPH09505035A (en) 1997-05-20
PL314187A1 (en) 1996-09-02
KR960705815A (en) 1996-11-08
NZ274848A (en) 1998-03-25
CO4290432A1 (en) 1996-04-17
DE59409094D1 (en) 2000-02-24
ZA948669B (en) 1995-07-04

Similar Documents

Publication Publication Date Title
AU690588B2 (en) Novel pyrazine carboxamide derivatives, their production and their use in medicaments
CA2148928A1 (en) Pharmacologically active pyridine derivatives and processes for the preparation thereof
AU5485698A (en) Oxyiminopregnancarbolactone
AU6194694A (en) Nor-bile acid derivatives, processes for their preparation and the use of these compounds as medicaments
AU5799294A (en) Isoxazole-4-carboxamides and hydroxy-alkylidenecyanoacetamides, pharmaceuticals containing these compounds and their use
GEP20002331B (en) Alkylated Raphamicine Derivatives
MY106280A (en) Novel benzopyrido piperidine, piperidylidene and piperazine compounds, compositions, methods of manufacture and methods of use.
MY109143A (en) Sulfonamido-and sulfonamidocarbonylpyridine 2-carboxamides and their pyridine-n-oxides, process for their preparation and their use as pharmaceuticals
WO1996032003A3 (en) Tetrahydroimidazopyridoindolediones and their use as medicaments
MY129973A (en) Sulphonylbenzyl-substituted pyridones.
AU6542986A (en) Pyridyl-methylthio substituted benzimidazoles
HUT51269A (en) Process for producing benzimidazole derivatives and pharmaceutical compositions comprising same
HRP930239A2 (en) Anti-inflamatory 4-aminophenol derivatives
AU4780397A (en) Nitrate esters of corticoid compounds and pharmaceutical applications thereof
AU1890295A (en) Piperidines and pyrrolidines
MY117090A (en) Substituted benzamidines, their preparation and their use as pharmaceutical compounds
AU669122B2 (en) New pyrazine derivatives, their preparation and their use
AU6697786A (en) New derivatives of 1-sulphonyl 2-oxo-5-alkoxy pyrrolidine, their preparation process, their use as medicaments and the compositions containing them
AU2861389A (en) Disubstituted pyridines
AU646439B2 (en) Novel retinoids
IL97795A0 (en) Cycloalkano(b)dihydroindoles and-indolesulphonamides substituted by heterocycles,their preparation and pharmaceutical compositions containing them
CA2421990A1 (en) .beta.-thioamino acids
AU686955B2 (en) Process to obtain benzoxazines to be used for the synthesis of ofloxazine, levofloxazine and derivatives
MY102270A (en) New furanuronic acid derivatives, process their production and their use.
AU1604592A (en) New 2-amino-5-cyano-1,4-dihydropyridines, processes for their preparation and their use in medicaments

Legal Events

Date Code Title Description
MK14 Patent ceased section 143(a) (annual fees not paid) or expired