AU693780B2 - Cancer treatment - Google Patents

Cancer treatment Download PDF

Info

Publication number: AU693780B2
Authority: AU; Australia
Prior art keywords: dppe; group; compound; compounds; antagonists
Prior art date: 1993-02-17
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Ceased

Application number

AU60352/94A

Other languages

English (en)

Other versions

AU6035294A (en

Inventor

Lorne J Brandes

Ron Reid

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

University of Manitoba

Original Assignee

University of Manitoba

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-02-17

Filing date

1994-02-17

Publication date

1998-07-09

1994-02-17 Application filed by University of Manitoba filed Critical University of Manitoba

1994-09-14 Publication of AU6035294A publication Critical patent/AU6035294A/en

1998-07-09 Application granted granted Critical

1998-07-09 Publication of AU693780B2 publication Critical patent/AU693780B2/en

2014-02-17 Anticipated expiration legal-status Critical

Status Ceased legal-status Critical Current

Links

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C217/06—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted
- C07C217/14—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring
- C07C217/18—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted
- C07C217/20—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted by halogen atoms, by trihalomethyl, nitro or nitroso groups, or by singly-bound oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C217/06—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted
- C07C217/14—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring
- C07C217/18—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted
- C07C217/22—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted by carbon atoms having at least two bonds to oxygen atoms

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
Organic Chemistry (AREA)
Molecular Biology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

AU60352/94A 1993-02-17 1994-02-17 Cancer treatment Ceased AU693780B2 (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
GB939303210A GB9303210D0 (en)	1993-02-17	1993-02-17	Cancer treatment
GB9303210		1993-02-17
PCT/CA1994/000087 WO1994018961A1 (en)	1993-02-17	1994-02-17	Cancer treatment

Related Child Applications (1)

Application Number	Title	Priority Date	Filing Date
AU14804/97A Division AU1480497A (en)	1993-02-17	1997-02-20	Cancer treatment

Publications (2)

Publication Number	Publication Date
AU6035294A AU6035294A (en)	1994-09-14
AU693780B2 true AU693780B2 (en)	1998-07-09

Family

ID=10730606

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
AU60352/94A Ceased AU693780B2 (en)	1993-02-17	1994-02-17	Cancer treatment
AU14804/97A Abandoned AU1480497A (en)	1993-02-17	1997-02-20	Cancer treatment

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
AU14804/97A Abandoned AU1480497A (en)	1993-02-17	1997-02-20	Cancer treatment

Country Status (6)

Country	Link
EP (1)	EP0684817A1 (ja)
JP (2)	JP2834328B2 (ja)
KR (1)	KR960700698A (ja)
AU (2)	AU693780B2 (ja)
GB (1)	GB9303210D0 (ja)
WO (1)	WO1994018961A1 (ja)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5432168A (en) *	1993-12-27	1995-07-11	University Of Manitoba	Method of treatment of hormone-unresponsive metastatic prostate cancer
US6506876B1 (en) *	1994-10-11	2003-01-14	G.D. Searle & Co.	LTA4 hydrolase inhibitor pharmaceutical compositions and methods of use
US5585492A (en) *	1994-10-11	1996-12-17	G. D. Searle & Co.	LTA4 Hydrolase inhibitors
KR20000029975A (ko) *	1996-08-16	2000-05-25	둘락 노먼 씨.	히스타민수용체길항제의배합물을사용한상부기도알레르기반응의치료
US5869479A (en) *	1997-08-14	1999-02-09	Schering Corporation	Treatment of upper airway allergic responses
ATE278017T1 (de)	1998-04-21	2004-10-15	Max Planck Gesellschaft	Humaner k+ ionenkanal und therapeutische verwendungen davon
IL139975A0 (en) *	2000-11-29	2002-02-10	Univ Ramot	Anti proliferative drugs
US6630454B2 (en) *	2001-09-10	2003-10-07	Ramot At Tel-Aviv University Ltd.	Method and pharmaceutical composition for the treatment of cancer
CA2497180A1 (en) *	2002-09-04	2004-03-18	The University Of Manitoba	Treatment of metastatic breast cancer with anthracyclines, taxanes and an histamine antagonist
US10143686B2 (en)	2010-12-27	2018-12-04	The Curators Of The University Of Missouri	Oxidosqualene cyclase as a protein target for anticancer therapeutics
BR112017015013A2 (pt)	2015-01-19	2018-01-23	Belina Pharma Ab	anti-histamina para uso no tratamento de câncer da mama
KR102312100B1 (ko) *	2020-06-05	2021-10-14	(주)프론트바이오	항바이러스제 및 항우울제를 유효성분으로 함유하는 암 예방 또는 치료용 약학적 조성물
WO2023008921A1 (ko) *	2021-07-29	2023-02-02	(주)프론트바이오	항바이러스제 및 항우울제를 유효성분으로 함유하는 암 예방 또는 치료용 약학적 조성물

Citations (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4618611A (en) *	1982-12-28	1986-10-21	Richter Gedeon Vegyeszeti Gyar Rt	1-(aminoalkoxyphenyl)-1-phenyl-propanols, process for their preparation and pharmaceutical compositions containing them
US4645774A (en) *	1982-12-28	1987-02-24	Richter Gedeon Vegyeszeti Gyar Rt	Aminoethoxybenzylalcohol derivatives, process for their preparation and pharmaceutical compositions containing them
US4645779A (en) *	1982-12-28	1987-02-24	Richter Gedeon Vegyeszeti Gyar Rt	Dialkylaminoalkoxybenzylalcohol derivatives, process for their preparation and pharmaceutical compositions containing them

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3288806A (en) *	1964-03-23	1966-11-29	Parke Davis & Co	Alpha-(aminoethoxyphenyl)-alpha-alkylstilbenes
HU187204B (en) *	1982-12-28	1985-11-28	Richter Gedeon Vegyeszet	Process for producing new diethyl-amino-alkoxy-benzhydrol derivatives, acid additional salts, and quaternary salts and pharmaceutical compositions contatining them
ES2063574T3 (es) *	1990-12-17	1995-01-01	Univ Manitoba	Metodo de tratamiento mejorado para el cancer.

1993
- 1993-02-17 GB GB939303210A patent/GB9303210D0/en active Pending
1994
- 1994-02-17 KR KR1019950703444A patent/KR960700698A/ko not_active Ceased
- 1994-02-17 AU AU60352/94A patent/AU693780B2/en not_active Ceased
- 1994-02-17 EP EP94906813A patent/EP0684817A1/en not_active Withdrawn
- 1994-02-17 JP JP6518508A patent/JP2834328B2/ja not_active Expired - Lifetime
- 1994-02-17 WO PCT/CA1994/000087 patent/WO1994018961A1/en not_active Ceased
1997
- 1997-02-20 AU AU14804/97A patent/AU1480497A/en not_active Abandoned
1998
- 1998-01-05 JP JP10000167A patent/JPH10182490A/ja active Pending

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4618611A (en) *	1982-12-28	1986-10-21	Richter Gedeon Vegyeszeti Gyar Rt	1-(aminoalkoxyphenyl)-1-phenyl-propanols, process for their preparation and pharmaceutical compositions containing them
US4645774A (en) *	1982-12-28	1987-02-24	Richter Gedeon Vegyeszeti Gyar Rt	Aminoethoxybenzylalcohol derivatives, process for their preparation and pharmaceutical compositions containing them
US4645779A (en) *	1982-12-28	1987-02-24	Richter Gedeon Vegyeszeti Gyar Rt	Dialkylaminoalkoxybenzylalcohol derivatives, process for their preparation and pharmaceutical compositions containing them

Also Published As

Publication number	Publication date
EP0684817A1 (en)	1995-12-06
KR960700698A (ko)	1996-02-24
AU1480497A (en)	1997-05-15
AU6035294A (en)	1994-09-14
WO1994018961A1 (en)	1994-09-01
JPH10182490A (ja)	1998-07-07
GB9303210D0 (en)	1993-03-31
JP2834328B2 (ja)	1998-12-09
JPH08506593A (ja)	1996-07-16

Legal Events

Date	Code	Title	Description
2000-09-21	MK14	Patent ceased section 143(a) (annual fees not paid) or expired

Publication	Publication Date	Title
US5798339A (en)	1998-08-25	Treatment method for cancer
AU693780B2 (en)	1998-07-09	Cancer treatment
EP0583665B1 (en)	2003-03-05	Pharmaceutical composition and method for treating hyperlipidemia and arteriosclerosis
US5650425A (en)	1997-07-22	Permanently ionic derivatives of steroid hormones and their antagonists
US7026320B2 (en)	2006-04-11	Serotonergic agents
US5364843A (en)	1994-11-15	Agents for potentiating the effects of antitumor agents and combating multiple drug resistance
US5998467A (en)	1999-12-07	Medicine for oculopathy
IE51551B1 (en)	1987-01-07	Isoquinoline derivatives,process for their preparation and pharmaceutical formulations containing them and their use
US5618846A (en)	1997-04-08	Treatment method for cancer
Bhatnagar et al.	2022	Recent developments of antipsychotic drugs with phenothiazine hybrids: A review.
CA2149691A1 (en)	1995-11-20	Medicament for therapeutic and prophylactic treatment of diseases caused by smooth muscle cell hyperplasia
US5543422A (en)	1996-08-06	Heterocyclic amines
US20100273763A1 (en)	2010-10-28	Organometallic complexes as therapeutic agents
US6284799B1 (en)	2001-09-04	Cancer treatment
AU749157B2 (en)	2002-06-20	Cancer treatment
CA2156162C (en)	2007-07-03	Cancer treatment
AU2017204652B2 (en)	2018-08-16	Treatment of Type I and Type II diabetes
JPS61172864A (ja)	1986-08-04	アルキン誘導体
US20090215794A1 (en)	2009-08-27	Serotonergic agents
KR900006856B1 (ko)	1990-09-22	2, 6-디옥사비시클로[3.3.0]옥타논의 옥심 에테르
SU1398771A3 (ru)	1988-06-15	Способ получени замещенных бензамидов
JP2001523717A (ja)	2001-11-27	異常細胞増殖、下痢および白痢によって特徴付けられる鎌状細胞病、炎症性の疾病を治療または予防するための置換ジフェニルインダノン、インダンおよびインドール化合物の使用
KR820001235B1 (ko)	1982-07-07	알킬티오페녹시프로파놀아민의 제조방법
JP2000505473A (ja)	2000-05-09	医薬化合物
IE47449B1 (en)	1984-03-21	Alkylthiophenoxypropanolamines