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AU710880B2 - Nucleic acid and amino acid sequences relating to helicobacter pylori for diagnostics and therapeutics - Google Patents
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AU710880B2 - Nucleic acid and amino acid sequences relating to helicobacter pylori for diagnostics and therapeutics - Google Patents

Nucleic acid and amino acid sequences relating to helicobacter pylori for diagnostics and therapeutics Download PDF

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AU710880B2
AU710880B2 AU63278/96A AU6327896A AU710880B2 AU 710880 B2 AU710880 B2 AU 710880B2 AU 63278/96 A AU63278/96 A AU 63278/96A AU 6327896 A AU6327896 A AU 6327896A AU 710880 B2 AU710880 B2 AU 710880B2
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pylori
polypeptide
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AU6327896A (en
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O. Thomas Berglindh
Bjorn L. Mellgard
Douglas Smith
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AstraZeneca AB
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Priority claimed from PCT/US1996/009122 external-priority patent/WO1996040893A1/en
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Priority to AU37956/99A priority Critical patent/AU713692B2/en
Priority to AU37960/99A priority patent/AU3796099A/en
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
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    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
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Description

WO 96/40893 PCT/US96/09122 -1- NUCLEIC ACID AND AMINO ACID SEQUENCES RELATING TO HELICOBACTER PYLORI FOR DIAGNOSTICS AND THERAPEUTICS Background of the Invention Helicobacter pylori is a gram-negative, S-shaped, microaerophilic bacterium that was discovered and cultured from a human gastric biopsy specimen. (Warren, J.R. and B.
Marshall, (1983) Lancet 1: 1273-1275; and Marshall et al., (1984) Microbios Lett. 25: 83- 88). H. pylori has been strongly linked to chronic gastritis and duodenal ulcer disease.
(Rathbone et. al., (1986) Gut 27: 635-641). Moreover, evidence is accumulating for an etiologic role of H. pylori in nonulcer dyspepsia, gastric ulcer disease, and gastric adenocarcinoma. (Blaser M. (1993) Trends Microbiol. 1: 255-260). Transmission of the bacteria occurs via the oral route, and the risk of infection increases with age. (Taylor, D.N. and M. J. Blaser, (1991) Epidemiol. Rev 13: 42-50). H. pylori colonizes the human gastric mucosa, establishing an infection that usually persists for decades. Infection by H.
pylori is prevalent worldwide. Developed countries have infection rates over 50% of the adult population, while developing countries have infection rates reaching 90% of the adults over the age of 20. (Hopkins R. J. and J. G. Morris (1994) Am. J. Med. 97: 265-277).
The bacterial factors necessary for colonization of the gastric environment, and for virulence of this pathogen, are poorly understood. Examples of the putative virulence factors include the following: urease, an enzyme that may play a role in neutralizing gastric t acid pH (Eaton et al., (1991) Infect. Immunol. 59: 2470-2475; Ferrero, R.L. and A. Lee (1991) Microb. Ecol. Hlth. Dis. 4: 121-134; Labigne et al., (1991) J. Bacteriol. 173: 1920- 1931); the bacterial flagellar proteins responsible for motility across the mucous layer.
(Hazell et al., (1986) J. Inf Dis. 153: 658-663; Leying et al., (1992) Mol. Microbiol. 6: 2863-2874; and Haas et al., (1993) Mol. Microbiol. 8: 753-760); Vac A. a bacterial toxin that induces the formation of intracellular vacuoles in epithelial cells (Schmitt, W. and R.
Haas, (1994) Molecular Microbiol. 12(2): 307-319); and several gastric tissue-specific adhesins. (Boren et al., (1993) Science 262: 1892-1895; Evans et al., (1993) J. Bacteriol.
175: 674-683; and Falk et al., (1993) Proc. Natl. Acad. Sci. USA 90: 2035-203).
Numerous therapeutic agents are currently available that eradicate H. pylori infections in vitro. (Huesca et. al., (1993) Zbl. Bakt. 280: 244-252; Hopkins, R. J. and J. G.
Morris, supra). However, many of these treatments are suboptimally effective in vivo because of bacterial resistance, altered drug distribution, patient non-compliance or poor drug availabilty. (Hopkins, R. J. and J. G. Morris, supra). Treatment with antibiotics combined with bismuth are part of the standard regime used to treat H. pylori infection.
(Malfertheiner, P. and J. E. Dominguez-Munoz (1993) Clinical Therapeutics 1.5 Supp. B: 37-48). Recently, combinations of a proton pump inhibitors and a single antibiotic have been shown to ameliorate duodenal ulcer disease. (Malfertheiner, P. and J. E. Dominguez- Munoz supra). However, methods employing antibiotic agents can have the problem of the SUBSTITUTE SHEET (RULE 26)
A
2 emergence of bacterial strains which are resistant to these agents. (Hopkins, R.J. and J.G.
Morris, supra). These limitations demonstrate that new more effective methods are needed to combat H. pylori infections in vivo. In particular, the design of new vaccines that may prevent infection by this bacterium is highly desirable.
Summary of the Invention In a first aspect, the present invention provides an isolated nucleic acid comprising a nucleotide sequence encoding an H pylori polypeptide or a fragment thereof, said nucleotide sequence being at least 60% homologous to a nucleotide sequence selected from SEQ ID NO: 17, SEQ ID NO: 297, SEQ ID NO: 963, SEQ ID NO: 975, SEQ ID 10 NO: 977, SEQ ID NO: 981, SEQ ID NO: 1086, SEQ ID NO: 1203, SEQ ID NO: 1278, SEQ ID NO: 1341, SEQ ID NO: 1351 and SEQ ID NO: 1405.
In a second aspect, the present invention provides a recombinant expression vector comprising the nucleic acid of the first aspect of the invention, wherein the nucleic acid includes a transcription regulatory element operably linked to the nucleotide sequence 15 that is comprised by the nucleic acid.
In a third aspect, the present invention provides a cell comprising the recombinant expression vector of the second aspect of the invention.
In a fourth aspect, the present invention provides a method for producing an H.
pylori polypeptide comprising culturing the cell of the third aspect of the invention under conditions that permit expression of the polypeptide.
In a fifth aspect, the present invention provides a purified polypeptide comprising an amino acid sequence of an H pylori polypeptide or a fragment thereof, wherein said amino acid sequence is at lest 60% homologous to an amino acid sequence selected from SEQ ID NO: 403, SEQ ID NO: 764, SEQ ID NO: 767, SEQ ID NO: 797, SEQ ID NO: 812, SEQ ID NO: 83,3, SEQ ID NO: 1537, SEQ ID NO.: 1654, SEQ ID NO: 1729, SEQ ID NO: 1792, SEQ ID NO: 1802 and SEQ ID NO: 1856.
In a sixth aspect, the present invention provides a vaccine composition suitable for prophylactic or therapeutic treatment of an H. pylori infection, comprising an effective amount of a nucleic acid according to the first aspect of the invention.
In a seventh aspect, the present invention provides a vaccine composition suitable for prophylactic or therapeutic treatment of an H pylori infection, comprising an effective amount of a purified polypeptide of the fifth aspect of the invention.
In an eighth aspect, the present invention provides a method of treating a subject for H pylori infection comprising administering to the subject a vaccine composition of the sixth or seventh aspect of the invention, such that treatment for H pylori infection occurs.
In a ninth aspect, the present invention provides the use of a nucleic acid according to the first aspect of the invention in the manufacture of a vaccine, suitable for prophylactic or therapeutic treatment of an H pylori infection in a patient administered with the vaccine.
In a tenth aspect, the present invention provides the use of a purified polypeptide according to the fifth aspect of the invention in the manufacture of a vaccine, suitable for prophylactic or therapeutic treatment of an H pylori infection in a patient administered 15 with the vaccine.
In an eleventh aspect, the present invention provides a method for detecting the °:***presence of a Helicobacter nucleic acid in a sample comprising: contacting a sample with a nucleic acid according to the first aspect of the invention under conditions in which a hybrid can form between said nucleic acid and a Helicobacter nucleic acid in the sample; and detecting the hybrid formed in step wherein detection of a hybrid indicates the presence of a Helicobacter nucleic acid in the sample.
In preferred embodiments of the first aspect of the invention, the isolated nucleic acid is characterized in that: said nucleotide sequence encodes an H pylori cell envelope polypeptide or a fragment thereof and is at least 60% homologous to a nucleotide sequence selected from SEQ ID NO: 963, SEQ ID NO: 977, SEQ ID NO: 981, SEQ ID NO: 1086, SEQ ID NO: 1278 and SEQ ID NO: 1405; or said nucleotide sequence encodes an H pylori outer membrane polypeptide or a fragment thereof; or 2B said nucleotide sequence encodes an H pylori secreted or periplasmic polypeptide or a fragment thereof and is at lest 60% homologous to a nucleotide sequence selected from SEQ ID NO: 17, SEQ ID NO: 297, SEQ ID NO: 975, SEQ ID NO: 1203, SEQ ID NO: 1341 and SEQ ID NO: 1351; or said nucleotide sequence comprised by the nucleic acid is at least 70%, 80%, 98% or 99% homologous to the selected nucleotide sequence, or identical to the selected nucleotide sequence.
In preferred embodiments of the fifth aspect of the present invention, the purified 0. polypeptide is characterized in that: said H. pylori polypeptide or fragment thereof is an H. pylori cell envelope polypeptide or a fragment thereof and said amino acid sequence comprised by the purified polypeptide is at least 60% homologous to an amino acid sequence selected from SEQ ID NO: 764, SEQ ID NO: 812, SEQ ID NO: 833, SEQ ID NO: 1537, SEQ ID NO: 1729 and SEQ ID NO: 1856; or :15 said H. pylori cell envelope polypeptide or a fragment thereof is an H. pylori outer membrane polypeptide or a fragment thereof; or said H. pylori polypeptide or fragment thereof is an H pylori secreted or periplasmic polypeptide or a fragment thereof and said amino acid sequence comprised by the purified polypeptide is at least 60% homologous to an amino acid sequence selected from SEQ ID NO: 403, SEQ ID NO: 767, SEQ ID NO: 797, SEQ ID NO: 1654, SEQ ID NO: 1792 and SEQ ID NO: 1802, or said amino acid sequence comprised by the purified polypeptide is at least 90% 95%, 98% or 99% homologous to the selected amino acid sequence, or identical to the selected amino acid sequence.
In preferred embodiments of the sixth and seventh aspects of the present invention, the vaccine is characterized in that: the composition further comprises a pharmaceutically acceptable carrier, more preferably, the pharmaceutically acceptable carrier is an adjuvant, or the composition includes a substance selected from non-toxic derivatives of cholera toxin, procholeragenoid, fungal polysaccharides, phorbol esters, labile toxin of E.
coli, non-H.pylori bacterial lysates, block polymers, saponins, biodegradable microcapsules, ISCOMs, cochleates, liposomes and genetically engineered attenuated live viruses or bacteria.
Thus, the present invention relates to novel genes, genes encoding polypeptides such as bacterial surface proteins, from the organism Helicobacter pylori pylori), and other related genes, their products, and uses thereof. The nucleic acids and peptides of the present invention have utility for diagnostic and therapeutics for H.
pylori and other Helicobacter species. They can also be used to detect the present of H.
pylori and other Helicobacter species in a sample; and for use in screening compounds for the ability to interfere with the H. pylori life cycle or to inhibit H. pylori infection.
*10 More specifically, this invention features compositions of nucleic acids corresponding to entire coding sequences of H pylori proteins, including surface or secreted proteins or parts thereof, nucleic acids capable of binding mRNA from H pylori proteins to block protein translation, and methods for producing H. pylori proteins or parts thereof using peptide synthesis and recombinant DNA techniques. This invention also features 15 antibodies and nucleic acids useful as probes to detect H. pylori infection. In addition, S. vaccine compositions and methods for the protection or treatment of infection by H.
pylori are within the scope of this invention.
Detailed Description of the Drawings Figure I is a bar graph that depicts the antibody titer in serum of mice following immunization with specific H. pylori antigens.
Figure 2 is a bar graph that depicts the antibody titer in mucous of mice following immunization with specific H. pylori antigens. Figure 3 is a bar graph that depicts therapeutic immunization of H. pylori infected mice with specific antigens dissolved in HEPES buffer.
Figure 4 is a bar graph that depicts therapeutic immunization of H. pylori infected mice with specific antigens dissolved in buffer containing DOC.
Detailed Description of the Invention In one aspect, the invention features a recombinant or substantially pure preparation of H. pylori polypeptide of SEQ ID NO: 384. The invention also includes substantially pure nucleic acid encoding an H. pylori polypeptide of SEQ ID NO: 384, such nucleic acid WO 96/40893 PCT/US96/09122 is contained in SEQ ID NO: 1. The H. pylori polypeptide sequences of the invention described herein are contained in the Sequence Listing, and the nucleic acids encoding H.
pylori polypeptides of the invention are contained in the Sequence Listing.
In another aspect, the invention features a recombinant or substantially pure preparation of an H. pylori polypeptide selected from the group consisting of H. pylori polypeptides of SEQ ID NO: 384 through SEQ ID NO: 389, SEQ ID NO: 391 through SEQ ID NO: 400, SEQ ID NO: 402 through SEQ ID NO: 406, SEQ ID NO: 408, SEQ ID NO: 411 through SEQ ID NO: 412, SEQ ID NO: 414 through SEQ ID NO: 430, SEQ ID NO: 432 through SEQ ID NO: 434, SEQ ID NO: 436 through SEQ ID NO: 441, and SEQ ID NO: 443. The invention also includes substantially pure nucleic acid encoding an H. pylori polypeptide selected from the group consisting of H. pylori polypeptides SEQ ID NO: 384 through SEQ ID NO: 389, SEQ ID NO: 391 through SEQ ID NO: 400, SEQ ID NO: 402 through SEQ ID NO: 406, SEQ ID NO: 408, SEQ ID NO: 411 through SEQ ID NO: 412, SEQ ID NO: 414 through SEQ ID NO: 430, SEQ ID NO: 432 through SEQ ID NO: 434, SEQ ID NO: 436 through SEQ ID NO: 441, and SEQ ID NO: 443, such nucleic acids are contained in SEQ ID NO: 1 through SEQ ID NO: In another aspect, the invention features a recombinant or substantially pure preparation of an H. pylori polypeptide selected from the group consisting of H. pylori polypeptides of SEQ ID NO: 444, SEQ ID NO: 446 through SEQ ID NO: 448, SEQ ID NO: 450 through SEQ ID NO: 462, SEQ ID NO: 465 through SEQ ID NO: 466, SEQ ID NO: 468 through SEQ ID NO: 469, SEQ ID NO: 471 through SEQ ID NO: 473, SEQ ID NO: 475, SEQ ID NO: 478 through SEQ ID NO: 479, SEQ ID NO: 481 through SEQ ID NO: 484, SEQ ID NO: 486, SEQ ID NO: 488 through SEQ ID NO: 501, and SEQ ID NO: 503 through SEQ ID NO: 506. The invention also includes substantially pure nucleic acid encoding an H. pylori polypeptide selected from the group consisting of H pylori polypeptides of SEQ ID NO: 444, SEQ ID NO: 446 through SEQ ID NO: 448, SEQ ID NO: 450 through SEQ ID NO: 462, SEQ ID NO: 465 through SEQ ID NO: 466, SEQ ID NO: 468 through SEQ ID NO: 469, SEQ ID NO: 471 through SEQ ID NO: 473, SEQ ID NO: 475, SEQ ID NO: 478 through SEQ ID NO: 479, SEQ ID NO: 481 through SEQ ID NO: 484, SEQ ID NO: 486, SEQ ID NO: 488 through SEQ ID NO: 501, and SEQ ID NO: 503 through SEQ ID NO: 506, such nucleic acids are contained in SEQ ID NO: 51 through SEQ ID NO: 100.
In another aspect, the invention features a recombinant or substantially pure preparation of an H pylori polypeptide selected from the group consisting of H. pylori polypeptides of SEQ ID NO: 509 through SEQ ID NO: 510, SEQ ID NO: 512 through SEQ ID NO: 514, SEQ ID NO: 516, SEQ ID NO: 518 through SEQ ID NO: 520, SEQ ID NO: 522 through SEQ ID NO: 525, SEQ ID NO: 527 through SEQ ID NO: 533, SEQ ID NO: 535 through SEQ ID NO: 537, SEQ ID NO: 539 through SEQ ID NO: 540, SEQ ID NO: 542 through SEQ ID NO: 544, SEQ ID NO: 546 through SEQ ID NO: 548, SEQ ID NO: SUBSTITUTE SHEET (RULE 26) a WO 96/40893 PCT/US96/09122 -4- 550, SEQ ID NO: 553 through SEQ ID NO: 556, SEQ ID NO: 558, SEQ ID NO: 560, SEQ ID NO: 562 through SEQ ID NO: 568, SEQ ID NO: 570, and SEQ ID NO: 572 through SEQ ID NO: 575. The invention also includes substantially pure nucleic acid encoding an H. pylori polypeptide selected from the group consisting of H. pylori polypeptides of SEQ ID NO: 509 through SEQ ID NO: 510, SEQ ID NO: 512 through SEQ ID NO: 514, SEQ ID NO: 516, SEQ ID NO: 518 through SEQ ID NO: 520, SEQ ID NO: 522 through SEQ ID NO: 525, SEQ ID NO: 527 through SEQ ID NO: 533, SEQ ID NO: 535 through SEQ ID NO: 537, SEQ ID NO: 539 through SEQ ID NO: 540, SEQ ID NO: 542 through SEQ ID NO: 544, SEQ ID NO: 546 through SEQ ID NO: 548, SEQ ID NO: 550, SEQ ID NO: 553 through SEQ ID NO: 556, SEQ ID NO: 558, SEQ ID NO: 560, SEQ ID NO: 562 through SEQ ID NO: 568, SEQ ID NO: 570, and SEQ ID NO: 572 through SEQ ID NO: 575, such nucleic acids are contained in SEQ ID NO: 101 through SEQ ID NO: 150.
In another aspect, the invention features a recombinant or substantially pure preparation of an H. pylori polypeptide selected from the group consisting of H. pylori polypeptides of SEQ ID NO: 576 through SEQ ID NO: 579, SEQ ID NO: 581 through SEQ ID NO: 583, SEQ ID NO: 585 through SEQ ID NO: 593, SEQ ID NO: 596 through SEQ ID NO: 614, SEQ ID NO: 617 through SEQ ID NO: 623, SEQ ID NO: 625, SEQ ID NO: 627, SEQ ID NO: 629 through SEQ ID NO: 631, SEQ ID NO: 633, and SEQ ID NO: 635 through SEQ ID NO: 636. The invention also includes substantially pure nucleic acid encoding an H. pylori polypeptide selected from the group consisting of H. pylori polypeptides of SEQ ID NO: 576 through SEQ ID NO: 579, SEQ ID NO: 581 through SEQ ID NO: 583, SEQ ID NO: 585 through SEQ ID NO: 593, SEQ ID NO: 596 through SEQ ID NO: 614, SEQ ID NO: 617 through SEQ ID NO: 623, SEQ ID NO: 625, SEQ ID NO: 627, SEQ ID NO: 629 through SEQ ID NO: 631, SEQ ID NO: 633, and SEQ ID NO: 635 through SEQ ID NO: 636, such nucleic acids are contained in SEQ ID NO: 151 through SEQ ID NO: 200.
In another aspect, the invention features a recombinant or substantially pure preparation of an H. pylori polypeptide selected from the group consisting of H. pylori polypeptides of SEQ ID NO: 638 through SEQ ID NO: 640, SEQ ID NO: 642 through SEQ ID NO: 643, SEQ ID NO: 647, SEQ ID NO: 649 through SEQ ID NO: 651, SEQ ID NO: 653 through SEQ ID NO: 661, SEQ ID NO: 663 through SEQ ID NO: 670, SEQ ID NO: 673 through SEQ ID NO: 674, SEQ ID NO: 676, SEQ ID NO: 678 through SEQ ID NO: 683, SEQ ID NO: 687 through SEQ ID NO: 692, and SEQ ID NO: 694 through SEQ ID NO: 702. The invention also includes substantially pure nucleic acid encoding an H. pylori polypeptide selected from the group consisting of H. pylori polypeptides of SEQ ID NO: 638 through SEQ ID NO: 640, SEQ ID NO: 642 through SEQ ID NO: 643, SEQ ID NO: 647, SEQ ID NO: 649 through SEQ ID NO: 651, SEQ ID NO: 653 through SEQ ID NO: 661, SEQ ID NO: 663 through SEQ ID NO: 670, SEQ ID NO: 673 through SEQ ID NO: 674, SEQ ID NO: 676, SEQ ID NO: 678 through SEQ ID NO: 683, SEQ ID NO: 687 SUBSTITUTE SHEET (RULE 26) WO 96/40893 PCT/US96/09122 through SEQ ID NO: 692, and SEQ ID NO: 694 through SEQ ID NO: 702, such nucleic acids are contained in SEQ ID NO: 201 through SEQ ID NO: 250.
In another aspect, the invention features a recombinant or substantially pure preparation of an H pylori polypeptide selected from the group consisting of H. pylori polypeptides of SEQ ID NO: 705 through SEQ ID NO: 708, SEQ ID NO: 712 through SEQ ID NO: 714, SEQ ID NO: 716 through SEQ ID NO: 722, SEQ ID NO: 725 through SEQ ID NO: 730, SEQ ID NO: 732 through SEQ ID NO: 733, SEQ ID NO: 735 through SEQ ID NO: 744, SEQ ID NO: 746 through SEQ ID NO: 752, SEQ ID NO: 755 through SEQ ID NO: 757, SEQ ID NO: 759, SEQ ID NO: 761 through SEQ ID NO: 763, and SEQ ID NO: 767 through SEQ ID NO: 770. The invention also includes substantially pure nucleic acid encoding an H. pylori polypeptide selected from the group consisting of H. pylori polypeptides of SEQ ID NO: 705 through SEQ ID NO: 708, SEQ ID NO: 712 through SEQ ID NO: 714, SEQ ID NO: 716 through SEQ ID NO: 722, SEQ ID NO: 725 through SEQ ID NO: 730, SEQ ID NO: 732 through SEQ ID NO: 733, SEQ ID NO: 735 through SEQ ID NO: 744, SEQ ID NO: 746 through SEQ ID NO: 752, SEQ ID NO: 755 through SEQ ID NO: 757, SEQ ID NO: 759, SEQ ID NO: 761 through SEQ ID NO: 763, and SEQ ID NO: 767 through SEQ ID NO: 770, such nucleic acids are contained in SEQ ID NO: 251 through SEQ ID NO: 300.
In another aspect, the invention features a recombinant or substantially pure preparation of an H. pylori polypeptide selected from the group consisting of H. pylori polypeptides of SEQ ID NO: 771 through SEQ ID NO: 773, SEQ ID NO: 775, SEQ ID NO: 777, SEQ ID NO: 779 through SEQ ID NO: 784, SEQ ID NO: 786 through SEQ ID NO: 787, SEQ ID NO: 789 through SEQ ID NO: 792, SEQ ID NO: 794, SEQ ID NO: 796, SEQ ID NO: 798 through SEQ ID NO: 805, SEQ ID NO: 807 through SEQ ID NO: 811, SEQ ID NO: 813 through SEQ ID NO: 819, SEQ ID NO: 821 through SEQ ID NO: 822, SEQ ID NO: 824 through SEQ ID NO: 826, SEQ ID NO: 828 through SEQ ID NO: 832, and SEQ ID NO: 835. The invention also includes substantially pure nucleic acid encoding an H. pylori polypeptide selected from the group consisting of H. pylori polypeptides of SEQ ID NO: 771 through SEQ ID NO: 773, SEQ ID NO: 775, SEQ ID NO: 777, SEQ ID NO: 779 through SEQ ID NO: 784, SEQ ID NO: 786 through SEQ ID NO: 787, SEQ ID NO: 789 through SEQ ID NO: 792, SEQ ID NO: 794, SEQ ID NO: 796, SEQ ID NO: 798 through SEQ ID NO: 805, SEQ ID NO: 807 through SEQ ID NO: 811, SEQ ID NO: 813 through SEQ ID NO: 819, SEQ ID NO: 821 through SEQ ID NO: 822, SEQ ID NO: 824 through SEQ ID NO: 826, SEQ ID NO: 828 through SEQ ID NO: 832, and SEQ ID NO: 835, such nucleic acids are contained in SEQ ID NO: 301 through SEQ ID NO: 350.
In another aspect, the invention features a recombinant or substantially pure preparation of an H pylori polypeptide selected from the group consisting of H. pylori polypeptides of SEQ ID NO: 836 through SEQ ID NO: 841, SEQ ID NO: 843 through SEQ ID NO: 851, SEQ ID NO: 853, SEQ ID NO: 855 through SEQ ID NO: 857, SEQ ID NO: SUBSTITUTE SHEET (RULE 26) WO 96/40893 PCT/US96/09122 -6- 859 through SEQ ID NO: 862, SEQ ID NO: 866, SEQ ID NO: 868 through SEQ ID NO: 871, SEQ ID NO: 873 through SEQ ID NO: 876, and SEQ ID NO: 879. The invention also includes substantially pure nucleic acid encoding an H pylori polypeptide selected from the group consisting of H. pylori polypeptides of SEQ ID NO: 836 through SEQ ID NO: 841, SEQ ID NO: 843 through SEQ ID NO: 851, SEQ ID NO: 853, SEQ ID NO: 855 through SEQ ID NO: 857, SEQ ID NO: 859 through SEQ ID NO: 862, SEQ ID NO: 866, SEQ ID NO: 868 through SEQ ID NO: 871, SEQ ID NO: 873 through SEQ ID NO: 876, and SEQ ID NO: 879, such nucleic acids are contained in SEQ ID NO: 351 through SEQ ID NO: 383.
In another aspect, the invention features a recombinant or substantially pure preparation of an H. pylori polypeptide selected from the group consisting of H pylori polypeptides of SEQ ID NO: 385, SEQ ID NO: 390, SEQ ID NO: 401, SEQ ID NO: 407, SEQ ID NO: 409 through SEQ ID NO: 410, SEQ ID NO: 413, SEQ ID NO: 431, SEQ ID NO: 435, SEQ ID NO: 442, SEQ ID NO: 445, SEQ ID NO: 449, SEQ ID NO: 463 through SEQ ID NO: 464, SEQ ID NO: 467, SEQ ID NO: 470, SEQ ID NO: 474, SEQ ID NO: 476 through SEQ ID NO: 477, SEQ ID NO: 480, SEQ ID NO: 485, SEQ ID NO: 487, SEQ ID NO: 502, SEQ ID NO: 507 through SEQ ID NO: 508, SEQ ID NO: 511, SEQ ID NO: 515, SEQ ID NO: 517, SEQ ID NO: 521, SEQ ID NO: 526, SEQ ID NO: 534, SEQ ID NO: 538, SEQ ID NO: 541, SEQ ID NO: 545, SEQ ID NO: 549, SEQ ID NO: 551 through SEQ ID NO: 552, SEQ ID NO: 557, SEQ ID NO: 559, SEQ ID NO: 561, SEQ ID NO: 569, SEQ ID NO: 571, SEQ ID NO: 580, SEQ ID NO: 584, SEQ ID NO: 594 through SEQ ID NO: 595, SEQ ID NO: 615 through SEQ ID NO: 616, SEQ ID NO: 624, and SEQ ID NO: 626. The invention also includes substantially pure nucleic acid encoding an H pylori polypeptide selected from the group consisting of H. pylori polypeptides of SEQ ID NO: 385, SEQ ID NO: 390, SEQ ID NO: 401, SEQ ID NO: 407, SEQ ID NO: 409 through SEQ ID NO: 410, SEQ ID NO: 413, SEQ ID NO: 431, SEQ ID NO: 435, SEQ ID NO: 442, SEQ ID NO: 445, SEQ ID NO: 449, SEQ ID NO: 463 through SEQ ID NO: 464, SEQ ID NO: 467, SEQ ID NO: 470, SEQ ID NO: 474, SEQ ID NO: 476 through SEQ ID NO: 477, SEQ ID NO: 480, SEQ ID NO: 485, SEQ ID NO: 487, SEQ ID NO: 502, SEQ ID NO: 507 through SEQ ID NO: 508, SEQ ID NO: 511, SEQ ID NO: 515, SEQ ID NO: 517, SEQ ID NO: 521, SEQ ID NO: 526, SEQ ID NO: 534, SEQ ID NO: 538, SEQ ID NO: 541, SEQ ID NO: 545, SEQ ID NO: 549, SEQ ID NO: 551 through SEQ ID NO: 552, SEQ ID NO: 557, SEQ ID NO: 559, SEQ ID NO: 561, SEQ ID NO: 569, SEQ ID NO: 571, SEQ ID NO: 580, SEQ ID NO: 584, SEQ ID NO: 594 through SEQ ID NO: 595, SEQ ID NO: 615 through SEQ ID NO: 616, SEQ ID NO: 624, and SEQ ID NO: 626, such nucleic acids are contained in SEQ ID NO: 881 through SEQ ID NO: 930.
In another aspect, the invention features a recombinant or substantially pure preparation of an H. pylori polypeptide selected from the group consisting of H pylori polypeptides of SEQ ID NO: 628, SEQ ID NO: 632, SEQ ID NO: 634, SEQ ID NO: 637, SUBSTITUTE SHEET (RULE 26) WO 96/40893 PCT/US96/09122 -7- SEQ ID NO: 641, SEQ ID NO: 644 through SEQ ID NO: 646, SEQ ID NO: 648, SEQ ID NO: 652, SEQ ID NO: 662, SEQ ID NO: 671 through SEQ ID NO: 672, SEQ ID NO: 675, SEQ ID NO: 677, SEQ ID NO: 684 through SEQ ID NO: 686, SEQ ID NO: 693, SEQ ID NO: 703 through SEQ ID NO: 704, SEQ ID NO: 709 through SEQ ID NO: 711, SEQ ID NO: 715, SEQ ID NO: 723 through SEQ ID NO: 724, SEQ ID NO: 731, SEQ ID NO: 734, SEQ ID NO: 745, SEQ ID NO: 753 through SEQ ID NO: 754, SEQ ID NO: 758, SEQ ID NO: 760, SEQ ID NO: 764 through SEQ ID NO: 766, SEQ ID NO: 774, SEQ ID NO: 776, SEQ ID NO: 778, SEQ ID NO: 785, SEQ ID NO: 788, SEQ ID NO: 793, SEQ ID NO: 795, SEQ ID NO: 797, SEQ ID NO: 806, SEQ ID NO: 812, SEQ ID NO: 820, SEQ ID NO: 823, and SEQ ID NO: 827. The invention also includes substantially pure nucleic acid encoding an H pylori polypeptide selected from the group consisting of H pylori polypeptides of SEQ ID NO: 628, SEQ ID NO: 632, SEQ ID NO: 634, SEQ ID NO: 637, SEQ ID NO: 641, SEQ ID NO: 644 through SEQ ID NO: 646, SEQ ID NO: 648, SEQ ID NO: 652, SEQ ID NO: 662, SEQ ID NO: 671 through SEQ ID NO: 672, SEQ ID NO: 675, SEQ ID NO: 677, SEQ ID NO: 684 through SEQ ID NO: 686, SEQ ID NO: 693, SEQ ID NO: 703 through SEQ ID NO: 704, SEQ ID NO: 709 through SEQ ID NO: 711, SEQ ID NO: 715, SEQ ID NO: 723 through SEQ ID NO: 724, SEQ ID NO: 731, SEQ ID NO: 734, SEQ ID NO: 745, SEQ ID NO: 753 through SEQ ID NO: 754, SEQ ID NO: 758, SEQ ID NO: 760, SEQ ID NO: 764 through SEQ ID NO: 766, SEQ ID NO: 774, SEQ ID NO: 776, SEQ ID NO: 778, SEQ ID NO: 785, SEQ ID NO: 788, SEQ ID NO: 793, SEQ ID NO: 795, SEQ ID NO: 797, SEQ ID NO: 806, SEQ ID NO: 812, SEQ ID NO: 820, SEQ ID NO: 823, and SEQ ID NO: 827, such nucleic acids are contained in SEQ ID NO: 931 through SEQ ID NO: 980.
In another aspect, the invention features a recombinant or substantially pure preparation of an H. pylori polypeptide selected from the group consisting of H. pylori polypeptides of SEQ ID NO: 833 through SEQ ID NO: 834, SEQ ID NO: 842, SEQ ID NO: 852, SEQ ID NO: 854, SEQ ID NO: 858, SEQ ID NO: 863, SEQ ID NO: 864 through SEQ ID NO: 865, SEQ ID NO: 867, SEQ ID NO: 872, SEQ ID NO: 877 through SEQ ID NO: 878, and SEQ ID NO: 880. The invention also includes substantially pure nucleic acid encoding an H pylori polypeptide selected from the group consisting of H. pylori polypeptides of SEQ ID NO: 833 through SEQ ID NO: 834, SEQ ID NO: 842, SEQ ID NO: 852, SEQ ID NO: 854, SEQ ID NO: 858, SEQ ID NO: 863, SEQ ID NO: 864 through SEQ ID NO: 865, SEQ ID NO: 867, SEQ ID NO: 872, SEQ ID NO: 877 through SEQ ID NO: 878, and SEQ ID NO: 880, such nucleic acids are contained in SEQ ID NO: 981 through SEQ ID NO: 994.
In another aspect, the invention features a recombinant or substantially pure preparation of an H. pylori polypeptide selected from the group consisting of H. pylori polypeptides of SEQ ID NO: 1446 through SEQ ID NO: 1461, SEQ ID NO: 1463, and SEQ ID NO: 1465 through SEQ ID NO: 1495. The invention also includes substantially SUBSTITUTE SHEET (RULE 26) WO 96/40893 PCT/US96/09122 -8pure nucleic acid encoding an H. pylori polypeptide selected from the group consisting of H. pylori polypeptides SEQ ID NO: 1446 through SEQ ID NO: 1461, SEQ ID NO: 1463, and SEQ ID NO: 1465 through SEQ ID NO: 1495, such nucleic acids are contained in SEQ ID NO: 995 through SEQ ID NO: SEQ ID NO: 1010, SEQ ID NO: 1012, and SEQ ID NO: 1014 through SEQ ID NO: 1044.
In another aspect, the invention features a recombinant or substantially pure preparation of an H. pylori polypeptide selected from the group consisting of H. pylori polypeptides of SEQ ID NO: 1497 through SEQ ID NO: 1515, and SEQ ID NO: 1517 through SEQ ID NO: 1545. The invention also includes substantially pure nucleic acid encoding an H. pylori polypeptide selected from the group consisting of H. pylori polypeptides SEQ ID NO: 1497 through SEQ ID NO: 1515, and SEQ ID NO: 1517 through SEQ ID NO: 1545, such nucleic acids are contained in SEQ ID NO: 1046 through SEQ ID NO: 1064, and SEQ ID NO: 1066 through SEQ ID NO: 1094.
In another aspect, the invention features a recombinant or substantially pure preparation of an H. pylori polypeptide selected from the group consisting of H. pylori polypeptides of SEQ ID NO: 1546 through SEQ ID NO: 1595. The invention also includes substantially pure nucleic acid encoding an H. pylori polypeptide selected from the group consisting of H pylori polypeptides SEQ ID NO: 1546 through SEQ ID NO: 1595, such nucleic acids are contained in SEQ ID NO: 1095 through SEQ ID NO: 1144.
In another aspect, the invention features a recombinant or substantially pure preparation of an H. pylori polypeptide selected from the group consisting of H. pylori polypeptides of SEQ ID NO: 1596 through SEQ ID NO: 1617, SEQ ID NO: 1620 through SEQ ID NO: 1645. The invention also includes substantially pure nucleic acid encoding an H. pylori polypeptide selected from the group consisting of H. pylori polypeptides SEQ ID NO: 1596 through SEQ ID NO: 1617, SEQ ID NO: 1620 through SEQ ID NO: 1645, such nucleic acids are contained in SEQ ID NO: 1145 through SEQ ID NO: 1166, and SEQ ID NO: 1169 through SEQ ID NO: 1194.
In another aspect, the invention features a recombinant or substantially pure preparation of an H. pylori polypeptide selected from the group consisting of H. pylori polypeptides of SEQ ID NO: 1646 through SEQ ID NO: 1681, and SEQ ID NO: 1683 through SEQ ID NO: 1695. The invention also includes substantially pure nucleic acid encoding an H. pylori polypeptide selected from the group consisting of H. pylori polypeptides SEQ ID NO: 1646 through SEQ ID NO: 1681, and SEQ ID NO: 1683 through SEQ ID NO: 1695, such nucleic acids are contained in SEQ ID NO: 1195 through SEQ ID NO: 1230, and SEQ ID NO: 1232 through SEQ ID NO: 1244.
In another aspect, the invention features a recombinant or substantially pure preparation of an H. pylori polypeptide selected from the group consisting of H. pylori polypeptides of SEQ ID NO: 1696 through SEQ ID NO: 1745. The invention also includes substantially pure nucleic acid encoding an H pylori polypeptide selected from the group SUBSTITUTE SHEET (RULE 26) WO 96/40893 PCT/US96/09122 -9consisting of H pylori polypeptides SEQ ID NO: 1696 through SEQ ID NO: 1745, such nucleic acids are contained in SEQ ID NO: 1245 through SEQ ID NO: 1294.
In another aspect, the invention features a recombinant or substantially pure preparation of an H. pylori polypeptide selected from the group consisting of H pylori polypeptides of SEQ ID NO: 1746 through SEQ ID NO: 1783, and SEQ ID NO: 1786 through SEQ ID NO: 1795. The invention also includes substantially pure nucleic acid encoding an H. pylori polypeptide selected from the group consisting of H. pylori polypeptides SEQ ID NO: 1746 through SEQ ID NO: 1783, and SEQ ID NO: 1786 through SEQ ID NO: 1795, such nucleic acids are contained in SEQ ID NO: 1295 through SEQ ID NO: 1332, and SEQ ID NO: 1335 through SEQ ID NO: 1344.
In another aspect, the invention features a recombinant or substantially pure preparation of an H. pylori polypeptide selected from the group consisting of H pylori polypeptides of SEQ ID NO: 1796 through SEQ ID NO: 1817, SEQ ID NO: 1819, SEQ ID NO: 1821, SEQ ID NO: 1823 through SEQ ID NO: 1836, and SEQ ID NO: 1838 through SEQ ID NO: 1845. The invention also includes substantially pure nucleic acid encoding an H pylori polypeptide selected from the group consisting of H. pylori polypeptides SEQ ID NO: 1796 through SEQ ID NO: 1817, SEQ ID NO: 1819, SEQ ID NO: 1821, SEQ ID NO: 1823 through SEQ ID NO: 1836, and SEQ ID NO: 1838 through SEQ ID NO: 1845, such nucleic acids are contained in SEQ ID NO: 1345 through SEQ ID NO: 1366, SEQ ID NO: 1368, SEQ ID NO: 1370, SEQ ID NO: 1372 through SEQ ID NO: 1385, and SEQ ID NO: 1387 through SEQ ID NO: 1394.
In another aspect, the invention features a recombinant or substantially pure preparation of an H. pylori polypeptide selected from the group consisting of H. pylori polypeptides of SEQ ID NO: 1846 through SEQ ID NO: 1896. The invention also includes substantially pure nucleic acid encoding an H. pylori polypeptide selected from the group consisting of H. pylori polypeptides SEQ ID NO: 1846 through SEQ ID NO: 1896, such nucleic acids are contained in SEQ ID NO: 1395 through SEQ ID NO: 1445.
In another aspect, the invention features a recombinant or substantially pure preparation of an H. pylori polypeptide selected from the group consisting of H. pylori polypeptides of the invention as set forth in the Sequence Listing. The invention also includes substantially pure nucleic acid encoding an H. pylori polypeptide selected from the group consisting of H. pylori polypeptides of the invention as set forth in the Sequence Listing. It should be understood that this invention encompasses each of the H. pylori polypeptides and nucleic acids encoding such polypeptides as identified in the Sequence Listing by a given sequence identification number. For example, a representative H pylori polypeptide is contained in SEQ ID NO: 1450. Therefore, this invention encompasses a recombinant or substantially pure preparation of an H. pylori polypeptide of SEQ ID NO: 1450. The invention also includes substantially pure nucleic acid encoding an H. pylori polypeptide of SEQ ID NO: 1450.
SUBSTITUTE SHEET (RULE 26) WO 96/40893 PCT/US96/09122 In another aspect, the invention pertains to any individual H. pylori polypeptide member or nucleic acid encoding such member from the above-identified groups of H pylori polypeptides SEQ ID NO: 1546 through SEQ ID NO: 1595) or nucleic acids SEQ ID NO: 1095-SEQ ID NO: 1144), as well as any subgroups from within the above-identified groups. Furthermore, the subgroups can preferably consists of 1, 3, 5, 20, 30 or 40 members of any of the groups identified above, as well as any combinations thereof. For example, the group consisting of H. pylori polypeptides SEQ ID NO: 1846 through SEQ ID NO: 1896 can be divided into one or more subgroups as follows: SEQ ID NO: 1846-SEQ ID NO: 1860; SEQ ID NO: 1861-SEQ ID NO: 1875; SEQ ID NO: 1876-SEQ ID NO: 1885; SEQ ID NO: 1886-SEQ ID NO: 1896; or any combinations thereof.
Particularly perferred is an isolated nucleic acid comprising a nucleotide sequence encoding an H. pylori cell envelope polypeptide or a fragment thereof. Such nucleic acid is selected from the group consisting of SEQ ID NO: 1020, SEQ ID NO: 1021, SEQ ID NO: 1036, SEQ ID NO: 1050, SEQ ID NO: 1071, SEQ ID NO: 1101, SEQ ID NO: 1135, SEQ ID NO: 1276, SEQ ID NO: 1150, SEQ ID NO: 1187, SEQ ID NO: 1192, SEQ ID NO: 1361, SEQ ID NO: 1379, SEQ ID NO: 1399, SEQ ID NO: 1403, SEQ ID NO: 1400, SEQ ID NO: 1189, SEQ ID NO: 1002, SEQ ID NO: 1213, SEQ ID NO: 1214, SEQ ID NO: 1215, SEQ ID NO: 1234, SEQ ID NO: 1236, SEQ ID NO: 1237, SEQ ID NO: 1224, SEQ ID NO: 1251, SEQ ID NO: 1262, SEQ ID NO: 1149, SEQ ID NO: 1220, SEQ ID NO: 1240, SEQ ID NO: 1164, SEQ ID NO: 1165, SEQ ID NO: 1404, SEQ ID NO: 1144, SEQ ID NO: 1182, SEQ ID NO: 1157, SEQ ID NO: 1160, SEQ ID NO: 1300, SEQ ID NO: 1321, SEQ ID NO: 1323, SEQ ID NO: 1329, SEQ ID NO: 1332, SEQ ID NO: 1345, SEQ ID NO: 1358, SEQ ID NO: 1375, SEQ ID NO: 1417, SEQ ID NO: 1283, SEQ ID NO: 1335, SEQ ID NO: 1368, SEQ ID NO: 1179, SEQ ID NO: 1255, SEQ ID NO: 1258, SEQ ID NO: 1044, SEQ ID NO: 1273, SEQ ID NO: 1219, SEQ ID NO: 1274, SEQ ID NO: 1210, SEQ ID NO: 1422, SEQ ID NO: 1302, SEQ ID NO: 1308, SEQ ID NO: 1310, SEQ ID NO: 1331, SEQ ID NO: 1432, SEQ ID NO: 1052, SEQ ID NO: 1091, SEQ ID NO: 1421, SEQ ID NO: 1069, SEQ ID NO: 1005, SEQ ID NO: 1007, SEQ ID NO: 1166, SEQ ID NO: 1177, SEQ ID NO: 1193, SEQ ID NO: 1206, SEQ ID NO: 1207, SEQ ID NO: 1304, SEQ ID NO: 1305, SEQ ID NO: 1346, SEQ ID NO: 1348, SEQ ID NO: 1350, SEQ ID NO: 1032, SEQ ID NO: 1053, SEQ ID NO: 1081, SEQ ID NO: 1124, SEQ ID NO: 1382, SEQ ID NO: 1437, SEQ ID NO: 1263, SEQ ID NO: 1173, SEQ ID NO: 1405, SEQ ID NO: 1406, SEQ ID NO: 1410, SEQ ID NO: 1086, SEQ ID NO: 1322, SEQ ID NO: 1266, SEQ ID NO: 1282, SEQ ID NO: 1271, SEQ ID NO: 1208, SEQ ID NO: 1126, SEQ ID NO: 1270, SEQ ID NO: 1278, SEQ ID NO: 1419, SEQ ID NO: 1125, SEQ ID NO: 1181, SEQ ID NO: 1416, SEQ ID NO: 1096, SEQ ID NO: 1082, SEQ ID NO: 1146, SEQ ID NO: 1145, SEQ ID NO: 1108, SEQ ID NO: 1148, SEQ ID NO: 1337, SEQ ID NO: 1338, SEQ ID NO: 1424, SEQ ID NO: 1000, SEQ ID NO: 1027, SEQ ID NO: 1175, SEQ SUBSTITUTE SHEET (RULE 26) WO 96/40893 PCT/US96/09122 -11- ID NO: 1330, SEQ ID NO: 217, SEQ ID NO: 217, SEQ ID NO: 367, SEQ ID NO: 91 1,SEQ ID NO: 944, SEQ ID NO: 18, SEQ ID NO: 107, SEQ ID NO: 894, SEQ ID NO: 943, SEQ ID NO: 203, SEQ ID NO: 85, SEQ ID NO: 290, SEQ ID NO: 5, SEQ ID NO: 199, SEQ ID NO: 992, SEQ ID NO: 934, SEQ ID NO: 899, SEQ ID NO: 302, SEQ ID NO: 215, SEQ ID NO: 893, SEQ ID NO: 984, SEQ ID NO: 97,SEQ ID NO: 22, SEQ ID NO: 49, SEQ ID NO: 309, SEQ ID NO: 150, SEQ ID NO: 240, SEQ ID NO: 957, SEQ ID NO: 57, SEQ ID NO: 2, SEQ ID NO: 92, SEQ ID NO: 255, SEQ ID NO: 164, SEQ ID NO: 201, SEQ ID NO: 278, SEQ ID NO: 245, SEQ ID NO: 921, SEQ ID NO: 896, SEQ ID NO: 248, SEQ ID NO: 159, SEQ ID NO: 979, SEQ ID NO: 194, SEQ ID NO: 194, SEQ ID NO: 946, SEQ ID NO: 916, SEQ ID NO: 76, SEQ ID NO: 905, SEQ ID NO: 914, SEQ ID NO: 931, SEQ ID NO: 50, SEQ ID NO: 250, SEQ ID NO: 969, SEQ ID NO: 66,SEQ ID NO: 275, SEQ ID NO: 330, SEQ ID NO: 204, SEQ ID NO: 383, SEQ ID NO: 303, SEQ ID NO: 70, SEQ ID NO: 983, SEQ ID NO: 972, SEQ ID NO: 929, SEQ ID NO: 972, SEQ ID NO: 936, SEQ ID NO: 267, SEQ ID NO: 197, SEQ ID NO: 55, SEQ ID NO: 54, SEQ ID NO: 210, SEQ ID NO: 90, SEQ ID NO: 15, SEQ ID NO: 913, SEQ ID NO: 227, SEQ ID NO: 79, SEQ ID NO: 191, SEQ ID NO: 238, SEQ ID NO: 274, SEQ ID NO: 27, SEQ ID NO: 258, SEQ ID NO: 295, SEQ ID NO: 10, SEQ ID NO: 160, SEQ ID NO: 225, SEQ ID NO: 964, SEQ ID NO: 166, SEQ ID NO: 56, SEQ ID NO: 980,SEQ ID NO: 903, SEQ ID NO: 261, SEQ ID NO: 71, SEQ ID NO: 955, SEQ ID NO: 361, SEQ ID NO: 58, SEQ ID NO: 114, SEQ ID NO: 940, SEQ ID NO: 960, SEQ ID NO: 144, SEQ ID NO: 362, SEQ ID NO: 40, SEQ ID NO: 285, SEQ ID NO: 11, SEQ ID NO: 161, SEQ ID NO: 974, SEQ ID NO: 111, SEQ ID NO: 316, SEQ ID NO: 257, SEQ ID NO: 78, SEQ ID NO: 966, SEQ ID NO: 352, SEQ ID NO: 981, SEQ ID NO: 158, SEQ ID NO: 989, SEQ ID NO: 963, SEQ ID NO: 48, SEQ ID NO: 68, SEQ ID NO: 135, SEQ ID NO: 910, SEQ ID NO: 236, SEQ ID NO: 241, SEQ ID NO: 949, SEQ ID NO: 945, SEQ ID NO: 207, SEQ ID NO: 977, SEQ ID NO: 978, SEQ ID NO: 994, SEQ ID NO: 163, SEQ ID NO: 256, SEQ ID NO: 287, SEQ ID NO: 184, SEQ ID NO: 45, SEQ ID NO: 136, SEQ ID NO: 214, SEQ ID NO: 16, SEQ ID NO: 192, SEQ ID NO: 373, SEQ ID NO: 892, SEQ ID NO: 239, SEQ ID NO: 34, SEQ ID NO: 340, SEQ ID NO: 41, SEQ ID NO: 332, SEQ ID NO: 134, and SEQ ID NO: 330.
In one embodiment, the H. pylori cell envelope polypeptide or a fragment thereof is an H. pylori flagella-associated polypeptide or a fragment thereof encoded by the nucleic acid selected from the group consisting of SEQ ID NO: 1020, SEQ ID NO: 1021, SEQ ID NO: 1036, SEQ ID NO: 1050, SEQ ID NO: 1071, SEQ ID NO: 1101, SEQ ID NO: 1135, SEQ ID NO: 1276, SEQ ID NO: 1150, SEQ ID NO: 1187, SEQ ID NO: 1192, SEQ ID NO: 1361, SEQ ID NO: 1379, SEQ ID NO: 1399, SEQ ID NO: 1403, SEQ ID NO: 1400, SEQ ID NO: 1189, SEQ ID NO: 217, SEQ ID NO: 367, SEQ ID NO: 91 1,SEQ ID NO: 944, SEQ ID NO: 18, SEQ ID NO: 107, SEQ ID NO: 894, SEQ ID NO: 943, SEQ ID NO: SUBSTITUTE SHEET (RULE 26) WO 96/40893 PCTIUS96/09122 -12- 203, SEQ ID NO: 85, SEQ ID NO: 290, SEQ ID NO: 5, SEQ ID NO: 199, SEQ ID NO: 992, SEQ ID NO: 934, SEQ ID NO: 899, SEQ ID NO: 302, and SEQ ID NO: 215.
In another embodiment, the H. pylori cell envelope polypeptide or a fragment thereof is an H. pylori inner membrane polypeptide or a fragment thereof encoded by the nucleic acid selected from the group consisting of SEQ ID NO: 1002, SEQ ID NO: 1213, SEQ ID NO: 1214, SEQ ID NO: 1215, SEQ ID NO: 1234, SEQ ID NO: 1236, SEQ ID NO: 1237, SEQ ID NO: 1224, SEQ ID NO: 1251, SEQ ID NO: 1262, SEQ ID NO: 1149, SEQ ID NO: 1220, SEQ ID NO: 1240, SEQ ID NO: 1164, SEQ ID NO: 1165, SEQ ID NO: 1404, SEQ ID NO: 1144, SEQ ID NO: 1182, SEQ ID NO: 1157, SEQ ID NO: 1160, SEQ ID NO: 1300, SEQ ID NO: 1321, SEQ ID NO: 1323, SEQ ID NO: 1329, SEQ ID NO: 1332, SEQ ID NO: 1345, SEQ ID NO: 1358, SEQ ID NO: 1375, SEQ ID NO: 1417, SEQ ID NO: 1283, SEQ ID NO: 1335, SEQ ID NO: 1368, SEQ ID NO: 1179, SEQ ID NO: 1255, SEQ ID NO: 1258, SEQ ID NO: 1044, SEQ ID NO: 1273, SEQ ID NO: 893, SEQ ID NO: 984, SEQ ID NO: 97,SEQ ID NO: 22, SEQ ID NO: 49, SEQ ID NO: 309, SEQ ID NO: 150, SEQ ID NO: 240, SEQ ID NO: 957, SEQ ID NO: 57, SEQ ID NO: 2, SEQ ID NO: 92, SEQ ID NO: 255, SEQ ID NO: 164, SEQ ID NO: 201, SEQ ID NO: 278, SEQ ID NO: 245, SEQ ID NO: 921, SEQ ID NO: 896, SEQ ID NO: 248, SEQ ID NO: 159, SEQ ID NO: 979, SEQ ID NO: 194, SEQ ID NO: 194, SEQ ID NO: 946, SEQ ID NO: 916, SEQ ID NO: 76, SEQ ID NO: 905, SEQ ID NO: 914, SEQ ID NO: 931, SEQ ID NO: 50, SEQ ID NO: 250, SEQ ID NO: 969, SEQ ID NO: 66,SEQ ID NO: 275, SEQ ID NO: 330, SEQ ID NO: 204, SEQ ID NO: 383, SEQ ID NO: 303, SEQ ID NO: 70, SEQ ID NO: 983, SEQ ID NO: 972, SEQ ID NO: 929, SEQ ID NO: 972, SEQ ID NO: 936, SEQ ID NO: 267, SEQ ID NO: 197, SEQ ID NO: 55, SEQ ID NO: 54, and SEQ ID NO: 210.
In yet another embodiment, the H pylori cell envelope polypeptide or a fragment thereof is an H. pylori transporter polypeptide or a fragment thereof encoded by the nucleic acid selected from the group consisting of SEQ ID NO: 1219, SEQ ID NO: 1274, SEQ ID NO: 1210, SEQ ID NO: 1422, SEQ ID NO: 1302, SEQ ID NO: 1308, SEQ ID NO: 1310, SEQ ID NO: 1331, SEQ ID NO: 1432, SEQ ID NO: 1052, SEQ ID NO: 1091, SEQ ID NO: 1421, SEQ ID NO: 1069, SEQ ID NO: 1005, SEQ ID NO: 1007, SEQ ID NO: 1166, SEQ ID NO: 1177, SEQ ID NO: 1193, SEQ ID NO: 1206, SEQ ID NO: 1207, SEQ ID NO: 1304, SEQ ID NO: 1305, SEQ ID NO: 1346, SEQ ID NO: 1348, SEQ ID NO: 1350, SEQ ID NO: 1032, SEQ ID NO: 1053, SEQ ID NO: 1081, SEQ ID NO: 1124, SEQ ID NO: 1382, SEQ ID NO: 1437, SEQ ID NO: 1263, SEQ ID NO: 90, SEQ ID NO: 15, SEQ ID NO: 913, SEQ ID NO: 227, SEQ ID NO: 79, SEQ ID NO: 191, SEQ ID NO: 238, SEQ ID NO: 274, SEQ ID NO: 27, SEQ ID NO: 258, SEQ ID NO: 295, SEQ ID NO: 10, SEQ ID NO: 160, SEQ ID NO: 225, SEQ ID NO: 964, SEQ ID NO: 166, SEQ ID NO: 56, SEQ ID NO: 980,SEQ ID NO: 903, SEQ ID NO: 261, SEQ ID NO: 71, SEQ ID NO: 955, SEQ ID NO: 361, SEQ ID NO: 58, SEQ ID NO: 114, SEQ ID NO: 940, SEQ ID NO: 960, SEQ ID NO: 144, SEQ ID NO: 362, SEQ ID NO: 40, SEQ ID NO: 285, SEQ ID NO: 11, SEQ SUBSTITUTE SHEET (RULE 26) WO 96/40893 PCT/US96/09122 -13- ID NO: 161, SEQ ID NO: 974, SEQ ID NO: 111, SEQ ID NO: 316, SEQ ID NO: 257, SEQ ID NO: 78, and SEQ ID NO: 966.
In yet a further embodiment, the H. pylori cell envelope polypeptide or a fragment thereof is an H. pylori outer membrane polypeptide or a fragment thereof encoded by the nucleic acid selected from the group consisting of SEQ ID NO: 1173, SEQ ID NO: 1405, SEQ ID NO: 1406, SEQ ID NO: 1410, SEQ ID NO: 1086, SEQ ID NO: 1322. SEQ ID NO: 1266, SEQ ID NO: 1282, SEQ ID NO: 1271, SEQ ID NO: 1208, SEQ ID NO: 1126, SEQ ID NO: 1270, SEQ ID NO: 1278, SEQ ID NO: 1419, SEQ ID NO: 1125, SEQ ID NO: 1181, SEQ ID NO: 1416, SEQ ID NO: 1096, SEQ ID NO: 1082, SEQ ID NO: 1146, SEQ ID NO: 1145, SEQ ID NO: 1108, SEQ ID NO: 1148, SEQ ID NO: 1337, SEQ ID NO: 1338, SEQ ID NO: 1424, SEQ ID NO: 1000, SEQ ID NO: 1027, SEQ ID NO: 1175, SEQ ID NO: 1330, SEQ ID NO: 352, SEQ ID NO: 981, SEQ ID NO: 158, SEQ ID NO: 989, SEQ ID NO: 963, SEQ ID NO: 48, SEQ ID NO: 68, SEQ ID NO: 135, SEQ ID NO: 910, SEQ ID NO: 236, SEQ ID NO: 241, SEQ ID NO: 949, SEQ ID NO: 945, SEQ ID NO: 207, and SEQ ID NO: 977.
Particularly preferred is an isolated nucleic acid comprising a nucleotide sequence encoding an H. pylori cytoplasmic polypeptide or a fragment thereof. Such nucleic acid is selected from the group consisting of SEQ ID NO: 1147, SEQ ID NO: 1288, SEQ ID NO: 1324, SEQ ID NO: 1363, SEQ ID NO: 997, SEQ ID NO: 1015, SEQ ID NO: 1084, SEQ ID NO: 1094, SEQ ID NO: 1099, SEQ ID NO: 1229, SEQ ID NO: 1250, SEQ ID NO: 1268, SEQ ID NO: 1293, SEQ ID NO: 1339, SEQ ID NO: 1408, SEQ ID NO: 1429, SEQ ID NO: 1434, SEQ ID NO: 1228, SEQ ID NO: 1031, SEQ ID NO: 1034, SEQ ID NO: 1008, SEQ ID NO: 1061, SEQ ID NO: 1064, SEQ ID NO: 1191, SEQ ID NO: 1217, SEQ ID NO: 1365, SEQ ID NO: 1394, SEQ ID NO: 1414, SEQ ID NO: 1415, SEQ ID NO: 1435, SEQ ID NO: 1058, SEQ ID NO: 1059, SEQ ID NO: 1080, SEQ ID NO: 1128, SEQ ID NO: 1133, SEQ ID NO: 1211, SEQ ID NO: 1252, SEQ ID NO: 1253, SEQ ID NO: 1286, SEQ ID NO: 1289, SEQ ID NO: 1291, SEQ ID NO: 1303, SEQ ID NO: 1396, SEQ ID NO: 996, SEQ ID NO: 1095, SEQ ID NO: 1156, SEQ ID NO: 1158, SEQ ID NO: 1159, SEQ ID NO: 1277, SEQ ID NO: 1038, SEQ ID NO: 1257, SEQ ID NO: 1357, SEQ ID NO: 1436, SEQ ID NO: 1047, SEQ ID NO: 1055, SEQ ID NO: SEQ ID NO: 1141, SEQ ID NO: 1227, SEQ ID NO: 1327, SEQ ID NO: 1412, SEQ ID NO: 1003, SEQ ID NO: 1087, SEQ ID NO: 1116, SEQ ID NO: 1130, SEQ ID NO: 1132, SEQ ID NO: 1185, SEQ ID NO: 1188, SEQ ID NO: 1198, SEQ ID NO: 1218, SEQ ID NO: 1244, SEQ ID NO: 1306, SEQ ID NO: 1325, SEQ ID NO: 1397, SEQ ID NO: 1398, SEQ ID NO: 1407, SEQ ID NO: 1433, SEQ ID NO: 1216, SEQ ID NO: 1239, SEQ ID NO: 1362, SEQ ID NO: 1017, SEQ ID NO: 1019, SEQ ID NO: 1360, SEQ ID NO: 1423, SEQ ID NO: 1425, SEQ ID NO: 1374, SEQ ID NO: 1028, SEQ ID NO: 1037, SEQ ID NO: 1077, SEQ ID NO: 1115, SEQ ID NO: 1232, SEQ ID NO: 1241, SEQ ID NO: 1267, SEQ ID NO: 1163, SEQ ID NO: 1068, SEQ ID NO: 1025, SEQ ID NO: 1042, SEQ ID NO: 1046, SEQ ID NO: SUBSTITUTE SHEET (RULE 26) WO 96/40893 PCT/US96/09122 -14- 1056, SEQ ID NO: 1039, SEQ ID NO: 1072, SEQ ID NO: 1073, SEQ ID NO: 1092, SEQ ID NO: 1100, SEQ ID NO: 1102, SEQ ID NO: 1103, SEQ ID NO: 1104, SEQ ID NO: 1111, SEQ ID NO: 1119, SEQ ID NO: 1136, SEQ ID NO: 1137, SEQ ID NO: 1140, SEQ ID NO: 1142, SEQ ID NO: 1233, SEQ ID NO: 1238, SEQ ID NO: 1243, SEQ ID NO: 1245, SEQ ID NO: 1247, SEQ ID NO: 1249, SEQ ID NO: 1261, SEQ ID NO: 1269, SEQ ID NO: 1279, SEQ ID NO: 1284, SEQ ID NO: 1290, SEQ ID NO: 1297, SEQ ID NO: 1328, SEQ ID NO: 1370, SEQ ID NO: 1372, SEQ ID NO: 1377, SEQ ID NO: 1383, SEQ ID NO: 1384, SEQ ID NO: 1385, SEQ ID NO: 1388, SEQ ID NO: 1401, SEQ ID NO: 1402, SEQ ID NO: 1418, SEQ ID NO: 1420, SEQ ID NO: 1427, SEQ ID NO: 1070, SEQ ID NO: 1151, SEQ ID NO: 1176, SEQ ID NO: 999, SEQ ID NO: 1006, SEQ ID NO: 1012, SEQ ID NO: 1018, SEQ ID NO: 1030, SEQ ID NO: 1033, SEQ ID NO: 1041, SEQ ID NO: 1049, SEQ ID NO: 1054, SEQ ID NO: 1057, SEQ ID NO: 1090, SEQ ID NO: 1097, SEQ ID NO: 1129, SEQ ID NO: 1139, SEQ ID NO: 1143, SEQ ID NO: 1152, SEQ ID NO: 1153, SEQ ID NO: 1155, SEQ ID NO: 1161, SEQ ID NO: 1162, SEQ ID NO: 1169, SEQ ID NO: 1170, SEQ ID NO: 1171, SEQ ID NO: 1180, SEQ ID NO: 1194, SEQ ID NO: 1195, SEQ ID NO: 1199, SEQ ID NO: 1200, SEQ ID NO: 1201, SEQ ID NO: 1202, SEQ ID NO: 1205, SEQ ID NO: 1312, SEQ ID NO: 1336, SEQ ID NO: 1349, SEQ ID NO: 1355, SEQ ID NO: 1359, SEQ ID NO: 1413, SEQ ID NO: 1426, SEQ ID NO: 1430, SEQ ID NO: 882, SEQ ID NO: 382, SEQ ID NO: 130, SEQ ID NO: 230, SEQ ID NO: 269, SEQ ID NO: 312, SEQ ID NO: 211, SEQ ID NO: 959, SEQ ID NO: 938, SEQ ID NO: 110, SEQ ID NO: 244, SEQ ID NO: 328, SEQ ID NO: 235, SEQ ID NO: 315, SEQ ID NO: 296, SEQ ID NO: 976, SEQ ID NO: 321, SEQ ID NO: 43, SEQ ID NO: 281, SEQ ID NO: 326, SEQ ID NO: 272, SEQ ID NO: 344, SEQ ID NO: 139, SEQ ID NO: 30, SEQ ID NO: 220, SEQ ID NO: 364, SEQ ID NO: 369, SEQ ID NO: 372, SEQ ID NO: 991, SEQ ID NO: 128, SEQ ID NO: 347, SEQ ID NO: 52, SEQ ID NO: 12, SEQ ID NO: 247, SEQ ID NO: 64, SEQ ID NO: 101, SEQ ID NO: 338, SEQ ID NO: 83, SEQ ID NO: 46, SEQ ID NO: 348, SEQ ID NO: 223, SEQ ID NO: 39, SEQ ID NO: 232, SEQ ID NO: 168, SEQ ID NO: 65, SEQ ID NO: 952, SEQ ID NO: 341, SEQ ID NO: 69, SEQ ID NO: 924, SEQ ID NO: 4, SEQ ID NO: 197, SEQ ID NO: 313, SEQ ID NO: 119, SEQ ID NO: 188, SEQ ID NO: 956, SEQ ID NO: 935, SEQ ID NO: 246, SEQ ID NO: 196, SEQ ID NO: 376, SEQ ID NO: 172, SEQ ID NO: 25, SEQ ID NO: 126, SEQ ID NO: 951, SEQ ID NO: 147, SEQ ID NO: 895, SEQ ID NO: 14, SEQ ID NO: 154, SEQ ID NO: 277, SEQ ID NO: 363, SEQ ID NO: 342, SEQ ID NO: 378, SEQ ID NO: 130, SEQ ID NO: 198, SEQ ID NO: 243, SEQ ID NO: 19, SEQ ID NO: 9, SEQ ID NO: 149, SEQ ID NO: 167, SEQ ID NO: 349, SEQ ID NO: 209, SEQ ID NO: 990, SEQ ID NO: 185, SEQ ID NO: 883, SEQ ID NO: 8, SEQ ID NO: 887, SEQ ID NO: 350, SEQ ID NO: 987, SEQ ID NO: 63, SEQ ID NO: 249, SEQ ID NO: 118, SEQ ID NO: 132, SEQ ID NO: 47, SEQ ID NO: 106, SEQ ID NO: 324, SEQ ID NO: 155, SEQ ID NO: 121, SEQ ID NO: 153, SEQ ID NO: 87, SEQ ID NO: 986, SEQ ID NO: 262, SEQ ID NO: 333, SEQ ID NO: 36, SEQ ID NO: 982, SEQ ID SUBSTITUTE SHEET (RULE 26) WO 96/40893 PCT/US96/09122 NO: 180, SEQ ID NO: 84, SEQ ID NO: 900, SEQ ID NO: 20, SEQ ID NO: 7, SEQ ID NO: 61, SEQ ID NO: 253, SEQ ID NO: 120, SEQ ID NO: 268, SEQ ID NO: 299, SEQ ID NO: 942, SEQ ID NO: 173, SEQ ID NO: 187, SEQ ID NO: 187, SEQ ID NO: 234, SEQ ID NO: 112, SEQ ID NO: 324, SEQ ID NO: 971, SEQ ID NO: 62, SEQ ID NO: 308, SEQ ID NO: 74, SEQ ID NO: 1, SEQ ID NO: 266, SEQ ID NO: 337, SEQ ID NO: 93, SEQ ID NO: 44, SEQ ID NO: 335, SEQ ID NO: 368, SEQ ID NO: 208, SEQ ID NO: 358, SEQ ID NO: 923, SEQ ID NO: 310, SEQ ID NO: 26, SEQ ID NO: 279, SEQ ID NO: 890, SEQ ID NO: 325, SEQ ID NO: 109, SEQ ID NO: 143, SEQ ID NO: 918, SEQ ID NO: 252, SEQ ID NO: 953, SEQ ID NO: 902, SEQ ID NO: 174, SEQ ID NO: 73, SEQ ID NO: 898, SEQ ID NO: 300, SEQ ID NO: 356, SEQ ID NO: 298, SEQ ID NO: 354, SEQ ID NO: 138, SEQ ID NO: 319, SEQ ID NO: 80, SEQ ID NO: 933, SEQ ID NO: 891, SEQ ID NO: 366, SEQ ID NO: 113, SEQ ID NO: 320, SEQ ID NO: 915, SEQ ID NO: 351, SEQ ID NO: 162, SEQ ID NO: 965, SEQ ID NO: 67, SEQ ID NO: 314, SEQ ID NO: 904, SEQ ID NO: 345, SEQ ID NO: 374, SEQ ID NO: 962, SEQ ID NO: 270, SEQ ID NO: 186, SEQ ID NO: SEQ ID NO: 379, SEQ ID NO: 889, SEQ ID NO: 967, SEQ ID NO: 973, SEQ ID NO: 280, SEQ ID NO: 170, SEQ ID NO: 985, and SEQ ID NO: 932.
In one embodiment, the H. pylori cytoplasmic polypeptide or a fragment thereof is an H. pylori polypeptide or a fragment thereof involved in energy conversion encoded by the nucleic acid selected from the group consisting of SEQ ID NO: 1147, SEQ ID NO: 1288, SEQ ID NO: 1324, SEQ ID NO: 1363, SEQ ID NO: 882, SEQ ID NO: 382, SEQ ID NO: 130, and SEQ ID NO: 230.
In another embodiment, the H. pylori cytoplasmic polypeptide or a fragment thereof is an H. pylori polypeptide or a fragment thereof involved in amino acid metabolism encoded by the nucleic acid selected from the group consisting of SEQ ID NO: 997, SEQ ID NO: 1015, SEQ ID NO: 1084, SEQ ID NO: 1094, SEQ ID NO: 1099, SEQ ID NO: 1229, SEQ ID NO: 1250, SEQ ID NO: 1268, SEQ ID NO: 1293, SEQ ID NO: 1339, SEQ ID NO: 1408, SEQ ID NO: 1429, SEQ ID NO: 1434, SEQ ID NO: 1228, SEQ ID NO: 1031, SEQ ID NO: 1034, SEQ ID NO: 1008, SEQ ID NO: 269, SEQ ID NO: 312, SEQ ID NO: 211, SEQ ID NO: 959, SEQ ID NO: 938, SEQ ID NO: 110, SEQ ID NO: 244, SEQ ID NO: 328, SEQ ID NO: 235, SEQ ID NO: 315, SEQ ID NO: 296, SEQ ID NO: 976, SEQ ID NO: 321, SEQ ID NO: 43, SEQ ID NO: 281, SEQ ID NO: 326, and SEQ ID NO: 272.
In yet another embodiment, the H. pylori cytoplasmic polypeptide or a fragment thereof is an H. pylori polypeptide or a fragment thereof involved in nucleotide metabolism encoded by the nucleic acid selected from the group consisting of SEQ ID NO: 1061, SEQ ID NO: 1064, SEQ ID NO: 1191, SEQ ID NO: 1217, SEQ ID NO: 1365, SEQ ID NO: 1394, SEQ ID NO: 1414, SEQ ID NO: 1415, SEQ ID NO: 1435, SEQ ID NO: 1058, SEQ ID NO: 1059, SEQ ID NO: 344, SEQ ID NO: 139, SEQ ID NO: 30, SEQ ID NO: 220, SUBSTITUTE SHEET (RULE 26) WO 96/40893 PCT/US96/09122 -16- SEQ ID NO: 364, SEQ ID NO: 369, SEQ ID NO: 372, SEQ ID NO: 991, SEQ ID NO: 128, SEQ ID NO: 347, and SEQ ID NO: 52.
In yet a further embodiment, the H pylori cytoplasmic polypeptide or a fragment thereof is an H. pylori polypeptide or a fragment thereof involved in carbohydrate metabolism encoded by the nucleic acid selected from the group consisting of SEQ ID NO: 1080, SEQ ID NO: 1128, SEQ ID NO: 1133, SEQ ID NO: 1211, SEQ ID NO: 1252, SEQ ID NO: 1253, SEQ ID NO: 1286, SEQ ID NO: 1289, SEQ ID NO: 1291, SEQ ID NO: 1303, SEQ ID NO: 1396, SEQ ID NO: 996, SEQ ID NO: 12, SEQ ID NO: 247, SEQ ID NO: 64, SEQ ID NO: 101, SEQ ID NO: 338, SEQ ID NO: 83, SEQ ID NO: 46, SEQ ID NO: 348, SEQ ID NO: 223, SEQ ID NO: 39, SEQ ID NO: 232, and SEQ ID NO: 168.
In another embodiment, the H. pylori cytoplasmic polypeptide or a fragment thereof is an H. pylori polypeptide or a fragment thereof involved in cofactor metabolism encoded by the nucleic acid selected from the group consisting of SEQ ID NO: 1095, SEQ ID NO: 1156, SEQ ID NO: 1158, SEQ ID NO: 1159, SEQ ID NO: 1277, SEQ ID NO: 1038, SEQ ID NO: 65, SEQ ID NO: 952, SEQ ID NO: 341, SEQ ID NO: 69, SEQ ID NO: 924, and SEQ ID NO: 4.
In another embodiment, the H. pylori cytoplasmic polypeptide or a fragment thereof is an H. pylori polypeptide or a fragment thereof involved in lipid metabolism encoded by the nucleic acid selected from the group consisting of SEQ ID NO: 1257, SEQ ID NO: 1357, SEQ ID NO: 1436, SEQ ID NO: 197, SEQ ID NO: 313, and SEQ ID NO: 119.
In another embodiment, the H. pylori cytoplasmic polypeptide or a fragment thereof is an H. pylori polypeptide or a fragment thereof involved in mRNA translation and ribosome biogenesis encoded by the nucleic acid selected from the group consisting of SEQ ID NO: 1047, SEQ ID NO: 1055, SEQ ID NO: SEQ ID NO: 1141, SEQ ID NO: 1227, SEQ ID NO: 1327, SEQ ID NO: 1412, SEQ ID NO: 188, SEQ ID NO: 956, SEQ ID NO: 935, SEQ ID NO: 246, SEQ ID NO: 196, and SEQ ID NO: 376.
In another embodiment, the H. pylori cytoplasmic polypeptide or a fragment thereof is an H. pylori polypeptide or a fragment thereof involved in genome replication, transcription, recombination and repair encoded by the nucleic acid selected from the group consisting of SEQ ID NO: 1003, SEQ ID NO: 1087, SEQ ID NO: 1116, SEQ ID NO: 1130, SEQ ID NO: 1132, SEQ ID NO: 1185, SEQ ID NO: 1188, SEQ ID NO: 1198, SEQ ID NO: 1218, SEQ ID NO: 1244, SEQ ID NO: 1306, SEQ ID NO: 1325, SEQ ID NO: 1397, SEQ ID NO: 1398, SEQ ID NO: 1407, SEQ ID NO: 1433, SEQ ID NO: 172, SEQ ID NO: SEQ ID NO: 126, SEQ ID NO: 951, SEQ ID NO: 147, SEQ ID NO: 895, SEQ ID NO: 14, SEQ ID NO: 154, SEQ ID NO: 277, SEQ ID NO: 363, SEQ ID NO: 342, SEQ ID NO: 378, SEQ ID NO: 130, SEQ ID NO: 198, SEQ ID NO: 243, SEQ ID NO: 19, and SEQ ID NO: 9.
In another embodiment, the H. pylori cytoplasmic polypeptide or a fragment thereof is an H. pylori polypeptide or a fragment thereof involved in outer membrane or cell wall SUBSTITUTE SHEET (RULE 26) WO 96/40893 PCT/US96/09122 -17biosynthesis encoded by the nucleic acid selected from the group consisting of SEQ ID NO: 1216, SEQ ID NO: 1239, SEQ ID NO: 1362, SEQ ID NO: 1017, SEQ ID NO: 1019, SEQ ID NO: 1360, SEQ ID NO: 149, SEQ ID NO: 167, SEQ ID NO: 349, SEQ ID NO: 209, SEQ ID NO: 990, SEQ ID NO: 185, SEQ ID NO: 883, and SEQ ID NO: 8.
In yet another embodiment, the H pylori cytoplasmic polypeptide is an H pylori chaperone polypeptide or a fragment thereof encoded by the nucleic acid selected from the group consisting of SEQ ID NO: 1423, SEQ ID NO: 1425, SEQ ID NO: 1374, SEQ ID NO: 887, SEQ ID NO: 350, and SEQ ID NO: 987.
Particularly preferred is an isolated nucleic acid comprising a nucleotide sequence encoding an H pylori secreted or periplasmic polypeptide or a fragment thereof. Such nucleic acid is selected from the group consisting of SEQ ID NO: 1004, SEQ ID NO: 1138, SEQ ID NO: 1067, SEQ ID NO: 1078, SEQ ID NO: 1314, SEQ ID NO: 1319, SEQ ID NO: 1378, SEQ ID NO: 1105, SEQ ID NO: 1114, SEQ ID NO: 1118, SEQ ID NO: 1120, SEQ ID NO: 1123, SEQ ID NO: 1127, SEQ ID NO: 1212, SEQ ID NO: 1223, SEQ ID NO: 1225, SEQ ID NO: 1246, SEQ ID NO: 1248, SEQ ID NO: 1259, SEQ ID NO: 1264, SEQ ID NO: 1265, SEQ ID NO: 1281, SEQ ID NO: 1285, SEQ ID NO: 1294, SEQ ID NO: 1298, SEQ ID NO: 1299, SEQ ID NO: 1315, SEQ ID NO: 1316, SEQ ID NO: 1317, SEQ ID NO: 1318, SEQ ID NO: 1344, SEQ ID NO: 1351, SEQ ID NO: 1353, SEQ ID NO: 1373, SEQ ID NO: 1380, SEQ ID NO: 1387, SEQ ID NO: 1389, SEQ ID NO: 1393, SEQ ID NO: 1411, SEQ ID NO: 1428, SEQ ID NO: 1431, SEQ ID NO: 1439, SEQ ID NO: 1043, SEQ ID NO: 1183, SEQ ID NO: 1184, SEQ ID NO: 1196, SEQ ID NO: 1197, SEQ ID NO: 1203, SEQ ID NO: 995, SEQ ID NO: 998, SEQ ID NO: 1001, SEQ ID NO: 1022, SEQ ID NO: 1023, SEQ ID NO: 1029, SEQ ID NO: 1040, SEQ ID NO: 1051, SEQ ID NO: 1062, SEQ ID NO: 1154, SEQ ID NO: 1320, SEQ ID NO: 1075, SEQ ID NO: 1106, SEQ ID NO: 1109, SEQ ID NO: 1134, SEQ ID NO: 1221, SEQ ID NO: 1226, SEQ ID NO: 1235, SEQ ID NO: 1301, SEQ ID NO: 1311, SEQ ID NO: 1326, SEQ ID NO: 1341, SEQ ID NO: 1354, SEQ ID NO: 1364, SEQ ID NO: 1366, SEQ ID NO: 1376, SEQ ID NO: 1391, SEQ ID NO: 1395, SEQ ID NO: 1445, SEQ ID NO: 1079, SEQ ID NO: 1186, SEQ ID NO: 1010, SEQ ID NO: 1016, SEQ ID NO: 1172, SEQ ID NO: 1174, SEQ ID NO: 117, SEQ ID NO: 254, SEQ ID NO: 24, SEQ ID NO: 242, SEQ ID NO: 950, SEQ ID NO: 263, SEQ ID NO: 286, SEQ ID NO: 947, SEQ ID NO: 51, SEQ ID NO: 177, SEQ ID NO: 156, SEQ ID NO: 190, SEQ ID NO: 375, SEQ ID NO: 222, SEQ ID NO: 21, SEQ ID NO: 912, SEQ ID NO: 148, SEQ ID NO: 202, SEQ ID NO: 224, SEQ ID NO: 112, SEQ ID NO: 32, SEQ ID NO: 339, SEQ ID NO: 182, SEQ ID NO: 228, SEQ ID NO: 152, SEQ ID NO: 219, SEQ ID NO: 137, SEQ ID NO: 318, SEQ ID NO: 141, SEQ ID NO: 165, SEQ ID NO: 334, SEQ ID NO: 13, SEQ ID NO: 297, SEQ ID NO: 35, SEQ ID NO: 216, SEQ ID NO: 908, SEQ ID NO: 124, SEQ ID NO: 75, SEQ ID NO: 927, SEQ ID NO: 221, SEQ ID NO: 178, SEQ ID NO: 169, SEQ ID NO: 293, SEQ ID NO: 289, SEQ ID NO: 926, SEQ ID NO: 948, SEQ ID NO: 115, SEQ ID NO: 251, SEQ ID NO: 345, SEQ SUBSTITUTE SHEET (RULE 26) WO 96/40893 PCT/US96/09122 -18- ID NO: 17, SEQ ID NO: 920, SEQ ID NO: 95, SEQ ID NO: 86, SEQ ID NO: 360, SEQ ID NO: 271, SEQ ID NO: 970, SEQ ID NO: 288, SEQ ID NO: 282, SEQ ID NO: 98, SEQ ID NO: 29, SEQ ID NO: 317, SEQ ID NO: 343, SEQ ID NO: 291, SEQ ID NO: 108, SEQ ID NO: 377, SEQ ID NO: 305, SEQ ID NO: 305, SEQ ID NO: 100, SEQ ID NO: 988, SEQ ID NO: 212, SEQ ID NO: 884, SEQ ID NO: 37, SEQ ID NO: 968, SEQ ID NO: 975, SEQ ID NO: 237, SEQ ID NO: 335, SEQ ID NO: 260, SEQ ID NO: 370, SEQ ID NO: 91, SEQ ID NO: 276, SEQ ID NO: 311, SEQ ID NO: 173, SEQ ID NO: 102, SEQ ID NO: 304, SEQ ID NO: 380, SEQ ID NO: 127, SEQ ID NO: 993, SEQ ID NO: 925, SEQ ID NO: 181, and SEQ ID NO: 171.
Particularly preferred is an isolated nucleic acid comprising a nucleotide sequence encoding an H. pylori surface or membrane polypeptide or a fragment thereof. Such nucleic acid is selected from the group consisting of SEQ ID NO: 1060, SEQ ID NO: 1110, SEQ ID NO: 1112, SEQ ID NO: 1230, SEQ ID NO: 1260, SEQ ID NO: 1280, SEQ ID NO: 1292, SEQ ID NO: 1296, SEQ ID NO: 1307, SEQ ID NO: 1442, SEQ ID NO: 1444, SEQ ID NO: 1122, SEQ ID NO: 1254, SEQ ID NO: 1256, SEQ ID NO: 1272, SEQ ID NO: 1275, SEQ ID NO: 1309, SEQ ID NO: 1313, SEQ ID NO: 1347, SEQ ID NO: 1352, SEQ ID NO: 1356, SEQ ID NO: 1438, SEQ ID NO: 1441, SEQ ID NO: 1009, SEQ ID NO: 1026, SEQ ID NO: 1048, SEQ ID NO: 1063, SEQ ID NO: 1190, SEQ ID NO: 1083, SEQ ID NO: 1113, SEQ ID NO: 1222, SEQ ID NO: 1295, SEQ ID NO: 1343, SEQ ID NO: 1392, SEQ ID NO: 1443, SEQ ID NO: 1085, SEQ ID NO: 1093, SEQ ID NO: 1117, SEQ ID NO: 1121, SEQ ID NO: 1131, SEQ ID NO: 1287, SEQ ID NO: 1440, SEQ ID NO: 1209, SEQ ID NO: 1342, SEQ ID NO: 1381, SEQ ID NO: 1390, SEQ ID NO: 1409, SEQ ID NO: 1035, SEQ ID NO: 1014, SEQ ID NO: 1088, SEQ ID NO: 1242, SEQ ID NO: 1178, SEQ ID NO: 1089, SEQ ID NO: 1340, SEQ ID NO: 1074, SEQ ID NO: 1107, SEQ ID NO: 1204, SEQ ID NO: 1066, SEQ ID NO: 381, SEQ ID NO: 229, SEQ ID NO: 323, SEQ ID NO: 371, SEQ ID NO: 284, SEQ ID NO: 116, SEQ ID NO: 3, SEQ ID NO: 6, SEQ ID NO: 907, SEQ ID NO: 193, SEQ ID NO: 145, SEQ ID NO: 59, SEQ ID NO: 322, SEQ ID NO: 94, SEQ ID NO: 306, SEQ ID NO: 939, SEQ ID NO: 205, SEQ ID NO: 123, SEQ ID NO: 906, SEQ ID NO: 928, SEQ ID NO: 346, SEQ ID NO: 129, SEQ ID NO: 307, SEQ ID NO: 133, SEQ ID NO: 131, SEQ ID NO: 886, SEQ ID NO: 179, SEQ ID NO: 104, SEQ ID NO: 213, SEQ ID NO: 359, SEQ ID NO: 140, SEQ ID NO: 146, SEQ ID NO: 327, SEQ ID NO: 365, SEQ ID NO: 33, SEQ ID NO: 331, SEQ ID NO: 175, SEQ ID NO: 200, SEQ ID NO: 292, SEQ ID NO: 23, SEQ ID NO: 336, SEQ ID NO: 301, SEQ ID NO: 28, SEQ ID NO: 941, SEQ ID NO: 103, SEQ ID NO: 231, SEQ ID NO: 176, SEQ ID NO: 31, SEQ ID NO: 917, SEQ ID NO: 151, SEQ ID NO: 922, SEQ ID NO: 265, SEQ ID NO: 142, SEQ ID NO: 259, SEQ ID NO: 122, SEQ ID NO: 206, SEQ ID NO: 96, SEQ ID NO: 353, SEQ ID NO: 38, SEQ ID NO: 89, SEQ ID NO: 77, SEQ ID NO: 954, SEQ ID NO: 264, SEQ ID NO: 937, SEQ ID NO: 226, SEQ ID NO: 283, SEQ ID NO: 88, SUBSTITUTE SHEET (RULE 26) WO 96/40893 PCT/US96/09122 -19- SEQ ID NO: 125, SEQ ID NO: 183, SEQ ID NO: 195, SEQ ID NO: 81, SEQ ID NO: 901, SEQ ID NO: 82, SEQ ID NO: 42, SEQ ID NO: 881, and SEQ ID NO: 885.
In one embodiment, the H. pylori surface or membrane polypeptide or a fragment thereof is an H pylori polypeptide or a fragment thereof having at least one membrane spanning region encoded by the nucleic acid selected from the group consisting of SEQ ID NO: 1060, SEQ ID NO: 1110, SEQ ID NO: 1112, SEQ ID NO: 1230, SEQ ID NO: 1260, SEQ ID NO: 1280, SEQ ID NO: 1292, SEQ ID NO: 1296, SEQ ID NO: 1307, SEQ ID NO: 1442, SEQ ID NO: 1444, SEQ ID NO: 381, SEQ ID NO: 229, SEQ ID NO: 323, SEQ ID NO: 371, SEQ ID NO: 284, SEQ ID NO: 116, SEQ ID NO: 3, SEQ ID NO: 6, SEQ ID NO: 907, SEQ ID NO: 193, SEQ ID NO: 145, SEQ ID NO: 59, SEQ ID NO: 322, SEQ ID NO: 94, SEQ ID NO: 306, and SEQ ID NO: 881.
In another embodiment, the H. pylori surface or membrane polypeptide or a fragment thereof is an H. pylori polypeptide or a fragment thereof having at least two membrane spanning regions encoded by the nucleic acid selected from the group consisting of SEQ ID NO: 1122, SEQ ID NO: 1254, SEQ ID NO: 1256, SEQ ID NO: 1272, SEQ ID NO: 1275, SEQ ID NO: 1309, SEQ ID NO: 1313, SEQ ID NO: 1347, SEQ ID NO: 1352, SEQ ID NO: 1356, SEQ ID NO: 1438, SEQ ID NO: 1441, SEQ ID NO: 1009, SEQ ID NO: 1026, SEQ ID NO: 1048, SEQ ID NO: 1063, SEQ ID NO: 1190, SEQ ID NO: 939, SEQ ID NO: 205, SEQ ID NO: 123, SEQ ID NO: 906, SEQ ID NO: 928, SEQ ID NO: 346, SEQ ID NO: 129, SEQ ID NO: 307, SEQ ID NO: 133, SEQ ID NO: 131, SEQ ID NO: 886, SEQ ID NO: 179, SEQ ID NO: 104, SEQ ID NO: 213, SEQ ID NO: 359, SEQ ID NO: 140, SEQ ID NO: 146, SEQ ID NO: 327, and SEQ ID NO: 365.
In yet another embodiment, the H pylori surface or membrane polypeptide or a fragment thereof is an H pylori polypeptide or a fragment thereof having at least three membrane spanning regions encoded by the nucleic acid selected from the group consisting of SEQ ID NO: 1083, SEQ ID NO: 1113, SEQ ID NO: 1222, SEQ ID NO: 1295, SEQ ID NO: 1343, SEQ ID NO: 1392, SEQ ID NO: 1443, SEQ ID NO: 33, SEQ ID NO: 331, SEQ ID NO: 175, SEQ ID NO: 200, SEQ ID NO: 292, SEQ ID NO: 23, and SEQ ID NO: 336.
In yet a further embodiment, the H. pylori surface or membrane polypeptide or a fragment thereof is an H. pylori polypeptide or a fragment thereof having at least four membrane spanning regions encoded by the nucleic acid selected from the group consisting of SEQ ID NO: 1085, SEQ ID NO: 1093, SEQ ID NO: 1117, SEQ ID NO: 1121, SEQ ID NO: 1131, SEQ ID NO: 1287, SEQ ID NO: 1440, SEQ ID NO: 1209, SEQ ID NO: 301, SEQ ID NO: 28, SEQ ID NO: 941, SEQ ID NO: 103, SEQ ID NO: 231, SEQ ID NO: 176, SEQ ID NO: 31, SEQ ID NO: 917, SEQ ID NO: 151, and SEQ ID NO: 922.
In another embodiment, the H. pylori surface or membrane polypeptide or a fragment thereof is an H. pylori polypeptide or a fragment thereof having at least five membrane spanning regions encoded by the nucleic acid selected from the group consisting of SEQ ID NO: 1342, SEQ ID NO: 1381, SEQ ID NO: 1390, SEQ ID NO: 1409, SEQ ID SUBSTITUTE SHEET (RULE 26) WO 96/40893 PCT/US96/09122 NO: 1035, SEQ ID NO: 265, SEQ ID NO: 142, SEQ ID NO: 259, SEQ ID NO: 122, SEQ ID NO: 206, and SEQ ID NO: 885.
In another embodiment, the H. pylori surface or membrane polypeptide or a fragment thereof is an H. pylori polypeptide or a fragment thereof having at least six membrane spanning regions encoded by the nucleic acid selected from the group consisting of SEQ ID NO: 1014, SEQ ID NO: 1088, SEQ ID NO: 1242, SEQ ID NO: 1178, SEQ ID NO: 96, SEQ ID NO: 353, SEQ ID NO: 38, SEQ ID NO: 89, SEQ ID NO: 77, SEQ ID NO: 954, SEQ ID NO: 264.
In another embodiment, the H pylori surface or membrane polypeptide or a fragment thereof is an H. pylori polypeptide or a fragment thereof having at least seven membrane spanning regions encoded by the nucleic acid selected from the group consisting of SEQ ID NO: 1089, SEQ ID NO: 1340, SEQ ID NO: 1074, SEQ ID NO: 1107, SEQ ID NO: 1204, SEQ ID NO: 1066, SEQ ID NO: 937, SEQ ID NO: 226, SEQ ID NO: 283, SEQ ID NO: 88, SEQ ID NO: 125, SEQ ID NO: 183, SEQ ID NO: 195, SEQ ID NO: 81, SEQ ID NO: 901, SEQ ID NO: 82, and SEQ ID NO: 42.
Particularly preferred is a purified or isolated H. pylori cell envelope polypeptide or a fragment thereof, wherein the polypeptide is selected from the group consisting of SEQ ID NO: 1471, SEQ ID NO: 1472, SEQ ID NO: 1487, SEQ ID NO: 1501, SEQ ID NO: 1522, SEQ ID NO: 1552, SEQ ID NO: 1586, SEQ ID NO: 1727, SEQ ID NO: 1601, SEQ ID NO: 1638, SEQ ID NO: 1643, SEQ ID NO: 1812, SEQ ID NO: 1830, SEQ ID NO: 1850, SEQ ID NO: 1854, SEQ ID NO: 1851, SEQ ID NO: 1640, SEQ ID NO: 1453, SEQ ID NO: 1664, SEQ ID NO: 1665, SEQ ID NO: 1666, SEQ ID NO: 1685, SEQ ID NO: 1687, SEQ ID NO: 1688, SEQ ID NO: 1675, SEQ ID NO: 1702, SEQ ID NO: 1713, SEQ ID NO: 1600, SEQ ID NO: 1671, SEQ ID NO: 1691, SEQ ID NO: 1615, SEQ ID NO: 1616, SEQ ID NO: 1855, SEQ ID NO: 1595, SEQ ID NO: 1633, SEQ ID NO: 1608, SEQ ID NO: 1611, SEQ ID NO: 1751, SEQ ID NO: 1772, SEQ ID NO: 1774, SEQ ID NO: 1780, SEQ ID NO: 1783, SEQ ID NO: 1796, SEQ ID NO: 1809, SEQ ID NO: 1826, SEQ ID NO: 1868, SEQ ID NO: 1734, SEQ ID NO: 1786, SEQ ID NO: 1819, SEQ ID NO: 1630, SEQ ID NO: 1706, SEQ ID NO: 1709, SEQ ID NO: 1495, SEQ ID NO: 1724, SEQ ID NO: 1670, SEQ ID NO: 1725, SEQ ID NO: 1661, SEQ ID NO: 1873, SEQ ID NO: 1753, SEQ ID NO: 1759, SEQ ID NO: 1761, SEQ ID NO: 1782, SEQ ID NO: 1883, SEQ ID NO: 1503, SEQ ID NO: 1542, SEQ ID NO: 1872, SEQ ID NO: 1520, SEQ ID NO: 1456, SEQ ID NO: 1458, SEQ ID NO: 1617, SEQ ID NO: 1628, SEQ ID NO: 1644, SEQ ID NO: 1657, SEQ ID NO: 1658, SEQ ID NO: 1755, SEQ ID NO: 1756, SEQ ID NO: 1797, SEQ ID NO: 1799, SEQ ID NO: 1801, SEQ ID NO: 1483, SEQ ID NO: 1504, SEQ ID NO: 1532, SEQ ID NO: 1575, SEQ ID NO: 1833, SEQ ID NO: 1888, SEQ ID NO: 1714, SEQ ID NO: 1624, SEQ ID NO: 1856, SEQ ID NO: 1857, SEQ ID NO: 1861, SEQ ID NO: 1537, SEQ ID NO: 1773, SEQ ID NO: 1717, SEQ ID NO: 1733, SEQ ID NO: 1722, SEQ ID NO: 1659, SEQ ID NO: 1577, SEQ ID NO: 1721, SEQ ID NO: 1729, SEQ SUBSTITUTE SHEET (RULE 26) WO 96/40893 PCT/US96/09122 -21- ID NO: 1870, SEQ ID NO: 1576, SEQ ID NO: 1632, SEQ ID NO: 1867, SEQ ID NO: 1547, SEQ ID NO: 1533, SEQ ID NO: 1597, SEQ ID NO: 1596, SEQ ID NO: 1559, SEQ ID NO: 1599, SEQ ID NO: 1788, SEQ ID NO: 1789, SEQ ID NO: 1875, SEQ ID NO: 1451, SEQ ID NO: 1478, SEQ ID NO: 1626, SEQ ID NO: 1781, SEQ ID NO: 660, SEQ ID NO: 660, SEQ ID NO: 855, SEQ ID NO: 534, SEQ ID NO: 675, SEQ ID NO: 404, SEQ ID NO: 518, SEQ ID NO: 464, SEQ ID NO: 672, SEQ ID NO: 640, SEQ ID NO: 490, SEQ ID NO: 755, SEQ ID NO: 389, SEQ ID NO: 635, SEQ ID NO: 877, SEQ ID NO: 637, SEQ ID NO: 477, SEQ ID NO: 772, SEQ ID NO: 658, SEQ ID NO: 463, SEQ ID NO: 852, SEQ ID NO: 503, SEQ ID NO: 411, SEQ ID NO: 441, SEQ ID NO: 782, SEQ ID NO: 575, SEQ ID NO: 691, SEQ ID NO: 724, SEQ ID NO: 452, SEQ ID NO: 386, SEQ ID NO: 497, SEQ ID NO: 712, SEQ ID NO: 591, SEQ ID NO: 638, SEQ ID NO: 740, SEQ ID NO: 697, SEQ ID NO: 569, SEQ ID NO: 470, SEQ ID NO: 700, SEQ ID NO: 586, SEQ ID NO: 823, SEQ ID NO: 627, SEQ ID NO: 627, SEQ ID NO: 684, SEQ ID NO: 551, SEQ ID NO: 478, SEQ ID NO: 508, SEQ ID NO: 545, SEQ ID NO: 628, SEQ ID NO: 443, SEQ ID NO: 702, SEQ ID NO: 776, SEQ ID NO: 461, SEQ ID NO: 737, SEQ ID NO: 809, SEQ ID NO: 642, SEQ ID NO: 879, SEQ ID NO: 773, SEQ ID NO: 468, SEQ ID NO: 842, SEQ ID NO: 788, SEQ ID NO: 624, SEQ ID NO: 788, SEQ ID NO: 644, SEQ ID NO: 727, SEQ ID NO: 631, SEQ ID NO: 450, SEQ ID NO: 448, SEQ ID NO: 653, SEQ ID NO: 495, SEQ ID NO: 400, SEQ ID NO: 541, SEQ ID NO: 673, SEQ ID NO: 482, SEQ ID NO: 622, SEQ ID NO: 689, SEQ ID NO: 736, SEQ ID NO: 417, SEQ ID NO: 716, SEQ ID NO: 762, SEQ ID NO: 395, SEQ ID NO: 587, SEQ ID NO: 669, SEQ ID NO: 758, SEQ ID NO: 593, SEQ ID NO: 451, SEQ ID NO: 827, SEQ ID NO: 502, SEQ ID NO: 719, SEQ ID NO: 469, SEQ ID NO: 715, SEQ ID NO: 847, SEQ ID NO: 453, SEQ ID NO: 527, SEQ ID NO: 652, SEQ ID NO: 745, SEQ ID NO: 567, SEQ ID NO: 848, SEQ ID NO: 430, SEQ ID NO: 748, SEQ ID NO: 396, SEQ ID NO: 588, SEQ ID NO: 795, SEQ ID NO: 523, SEQ ID NO: 791, SEQ ID NO: 714, SEQ ID NO: 481, SEQ ID NO: 765, SEQ ID NO: 837, SEQ ID NO: 833, SEQ ID NO: 585, SEQ ID NO: 865, SEQ ID NO: 764, SEQ ID NO: 440, SEQ ID NO: 465, SEQ ID NO: 555, SEQ ID NO: 526, SEQ ID NO: 687, SEQ ID NO: 692, SEQ ID NO: 693, SEQ ID NO: 677, SEQ ID NO: 649, SEQ ID NO: 812, SEQ ID NO: 820, SEQ ID NO: 880, SEQ ID NO: 590, SEQ ID NO:713, SEQ ID NO.750, SEQ ID NO:613, SEQ ID NO: 437, SEQ ID NO: 556, SEQ ID NO: 657, SEQ ID NO: 402, SEQ ID NO: 623, SEQ ID NO: 862, SEQ ID NO: 449, SEQ ID NO: 690, SEQ ID NO: 424, SEQ ID NO: 821, SEQ ID NO: 432, SEQ ID NO: 811, SEQ ID NO: 554, and SEQ ID NO: 809.
In one embodiment, the H. pylori cell envelope polypeptide or a fragment thereof is an H. pylori flagella-associated polypeptide or a fragment thereof selected from the group consisting of SEQ ID NO: 1471, SEQ ID NO: 1472, SEQ ID NO: 1487, SEQ ID NO: 1501, SEQ ID NO: 1522, SEQ ID NO: 1552, SEQ ID NO: 1586, SEQ ID NO: 1727, SEQ ID NO: 1601, SEQ ID NO: 1638, SEQ ID NO: 1643, SEQ ID NO: 1812, SEQ ID NO: 1830, SUBSTITUTE SHEET (RULE 26) WO 96/40893 PCT/US96/09122 -22- SEQ ID NO: 1850, SEQ ID NO: 1854, SEQ ID NO: 1851, SEQ ID NO: 1640. SEQ ID NO: 660, SEQ ID NO: 660, SEQ ID NO: 855, SEQ ID NO: 534, SEQ ID NO: 675, SEQ ID NO: 404, SEQ ID NO: 518, SEQ ID NO: 464, SEQ ID NO: 672, SEQ ID NO: 640, SEQ ID NO: 490, SEQ ID NO: 755, SEQ ID NO: 389, SEQ ID NO: 635, SEQ ID NO: 877, SEQ ID NO: 637, SEQ ID NO: 477, SEQ ID NO: 772, and SEQ ID NO: 658.
In another embodiment, the H. pylori cell envelope polypeptide or a fragment thereof is an H. pylori inner membrane polypeptide or a fragment thereof selected from the group consisting of SEQ ID NO: 1453, SEQ ID NO: 1664, SEQ ID NO: 1665, SEQ ID NO: 1666, SEQ ID NO: 1685, SEQ ID NO: 1687, SEQ ID NO: 1688, SEQ ID NO: 1675, SEQ ID NO: 1702, SEQ ID NO: 1713, SEQ ID NO: 1600, SEQ ID NO: 1671, SEQ ID NO: 1691, SEQ ID NO: 1615, SEQ ID NO: 1616, SEQ ID NO: 1855, SEQ ID NO: 1595, SEQ ID NO: 1633, SEQ ID NO: 1608, SEQ ID NO: 1611, SEQ ID NO: 1751, SEQ ID NO: 1772, SEQ ID NO: 1774, SEQ ID NO: 1780, SEQ ID NO: 1783, SEQ ID NO: 1796, SEQ ID NO: 1809, SEQ ID NO: 1826, SEQ ID NO: 1868, SEQ ID NO: 1734, SEQ ID NO: 1786, SEQ ID NO: 1819, SEQ ID NO: 1630, SEQ ID NO: 1706, SEQ ID NO: 1709, SEQ ID NO: 1495, SEQ ID NO: 1724, SEQ ID NO: 463, SEQ ID NO: 852, SEQ ID NO: 503, SEQ ID NO: 411, SEQ ID NO: 441, SEQ ID NO: 782, SEQ ID NO: 575, SEQ ID NO: 691, SEQ ID NO: 724, SEQ ID NO: 452, SEQ ID NO: 386, SEQ ID NO: 497, SEQ ID NO: 712, SEQ ID NO: 591, SEQ ID NO: 638, SEQ ID NO: 740, SEQ ID NO: 697, SEQ ID NO: 569, SEQ ID NO: 470, SEQ ID NO: 700, SEQ ID NO: 586, SEQ ID NO: 823, SEQ ID NO: 627, SEQ ID NO: 627, SEQ ID NO: 684, SEQ ID NO: 551, SEQ ID NO: 478, SEQ ID NO: 508, SEQ ID NO: 545, SEQ ID NO: 628, SEQ ID NO: 443, SEQ ID NO: 702, SEQ ID NO: 776, SEQ ID NO: 461, SEQ ID NO: 737, SEQ ID NO: 809, SEQ ID NO: 642, SEQ ID NO: 879, SEQ ID NO: 773, SEQ ID NO: 468, SEQ ID NO: 842, SEQ ID NO: 788, SEQ ID NO: 624, SEQ ID NO: 788, SEQ ID NO: 644, SEQ ID NO: 727, SEQ ID NO: 631, SEQ ID NO: 450, SEQ ID NO: 448, and SEQ ID NO: 653.
In yet another embodiment, the H. pylori cell envelope polypeptide or a fragment thereof is an H. pylori transporter polypeptide or a fragment thereof selected from the group consisting of SEQ ID NO: 1670, SEQ ID NO: 1725, SEQ ID NO: 1661, SEQ ID NO: 1873, SEQ ID NO: 1753, SEQ ID NO: 1759, SEQ ID NO: 1761, SEQ ID NO: 1782, SEQ ID NO: 1883, SEQ ID NO: 1503, SEQ ID NO: 1542, SEQ ID NO: 1872, SEQ ID NO: 1520, SEQ ID NO: 1456, SEQ ID NO: 1458, SEQ ID NO: 1617, SEQ ID NO: 1628, SEQ ID NO: 1644, SEQ ID NO: 1657, SEQ ID NO: 1658, SEQ ID NO: 1755, SEQ ID NO: 1756, SEQ ID NO: 1797, SEQ ID NO: 1799, SEQ ID NO: 1801, SEQ ID NO: 1483, SEQ ID NO: 1504, SEQ ID NO: 1532, SEQ ID NO: 1575, SEQ ID NO: 1833, SEQ ID NO: 1888, SEQ ID NO: 1714, SEQ ID NO: 495, SEQ ID NO: 400, SEQ ID NO: 541, SEQ ID NO: 673, SEQ ID NO: 482, SEQ ID NO: 622, SEQ ID NO: 689, SEQ ID NO: 736, SEQ ID NO: 417, SEQ ID NO: 716, SEQ ID NO: 762, SEQ ID NO: 395, SEQ ID NO: 587, SEQ ID NO: 669, SEQ ID NO: 758, SEQ ID NO: 593, SEQ ID NO: 451, SEQ ID NO: 827, SUBSTITUTE SHEET (RULE 26) WO 96/40893 PCT/US96/09122 -23- SEQ ID NO: 502, SEQ ID NO: 719, SEQ ID NO: 469, SEQ ID NO: 715, SEQ ID NO: 847, SEQ ID NO: 453, SEQ ID NO: 527, SEQ ID NO: 652, SEQ ID NO: 745, SEQ ID NO: 567, SEQ ID NO: 848, SEQ ID NO: 430, SEQ ID NO: 748, SEQ ID NO: 396, SEQ ID NO: 588, SEQ ID NO: 795, SEQ ID NO: 523, SEQ ID NO: 791, SEQ ID NO: 714, SEQ ID NO: 481, and SEQ ID NO: 765.
In another embodiment, the H. pylori cell envelope polypeptide or a fragment thereof is an H. pylori outer membrane polypeptide or a fragment thereof selected from the group consisting of SEQ ID NO: 1624, SEQ ID NO: 1856, SEQ ID NO: 1857, SEQ ID NO: 1861, SEQ ID NO: 1537, SEQ ID NO: 1773, SEQ ID NO: 1717, SEQ ID NO: 1733, SEQ ID NO: 1722, SEQ ID NO: 1659, SEQ ID NO: 1577, SEQ ID NO: 1721, SEQ ID NO: 1729, SEQ ID NO: 1870, SEQ ID NO: 1576, SEQ ID NO: 1632, SEQ ID NO: 1867, SEQ ID NO: 1547, SEQ ID NO: 1533, SEQ ID NO: 1597, SEQ ID NO: 1596, SEQ ID NO: 1559, SEQ ID NO: 1599, SEQ ID NO: 1788, SEQ ID NO: 1789, SEQ ID NO: 1875, SEQ ID NO: 1451, SEQ ID NO: 1478, SEQ ID NO: 1626, SEQ ID NO: 1781, SEQ ID NO: 837, SEQ ID NO: 833, SEQ ID NO: 585, SEQ ID NO: 865, SEQ ID NO: 764, SEQ ID NO: 440, SEQ ID NO: 465, SEQ ID NO: 555, SEQ ID NO: 526, SEQ ID NO: 687, SEQ ID NO: 692, SEQ ID NO: 693, SEQ ID NO: 677, SEQ ID NO: 649, and SEQ ID NO: 812.
Particularly preferred is a purified or isolated H. pylori cytoplasmic polypeptide or a fragment thereof, wherein the polypeptide is selected from the group consisting of SEQ ID NO: 1598, SEQ ID NO: 1739, SEQ ID NO: 1775, SEQ ID NO: 1814, SEQ ID NO: 1448, SEQ ID NO: 1466, SEQ ID NO: 1535, SEQ ID NO: 1545, SEQ ID NO: 1550, SEQ ID NO: 1680, SEQ ID NO: 1701, SEQ ID NO: 1719, SEQ ID NO: 1744, SEQ ID NO: 1790, SEQ ID NO: 1859, SEQ ID NO: 1880, SEQ ID NO: 1885, SEQ ID NO: 1679, SEQ ID NO: 1482, SEQ ID NO: 1485, SEQ ID NO: 1459, SEQ ID NO: 1512, SEQ ID NO: 1515, SEQ ID NO: 1642, SEQ ID NO: 1668, SEQ ID NO: 1816, SEQ ID NO: 1845, SEQ ID NO: 1865, SEQ ID NO: 1866, SEQ ID NO: 1886, SEQ ID NO: 1509, SEQ ID NO: 1510, SEQ ID NO: 1531, SEQ ID NO: 1579, SEQ ID NO: 1584, SEQ ID NO: 1662, SEQ ID NO: 1703, SEQ ID NO: 1704, SEQ ID NO: 1737, SEQ ID NO: 1740, SEQ ID NO: 1742, SEQ ID NO: 1754, SEQ ID NO: 1847, SEQ ID NO: 1447, SEQ ID NO: 1546, SEQ ID NO: 1607, SEQ ID NO: 1609, SEQ ID NO: 1610, SEQ ID NO: 1728, SEQ ID NO: 1489, SEQ ID NO: 1708, SEQ ID NO: 1808, SEQ ID NO: 1887, SEQ ID NO: 1498, SEQ ID NO: 1506, SEQ ID NO: 1592, SEQ ID NO: 1678, SEQ ID NO: 1778, SEQ ID NO: 1863, SEQ ID NO: 1454, SEQ ID NO: 1538, SEQ ID NO: 1567, SEQ ID NO: 1581, SEQ ID NO: 1583, SEQ ID NO: 1636, SEQ ID NO: 1639, SEQ ID NO: 1649, SEQ ID NO: 1669, SEQ ID NO: 1695, SEQ ID NO: 1757, SEQ ID NO: 1776, SEQ ID NO: 1848, SEQ ID NO: 1849, SEQ ID NO: 1858, SEQ ID NO: 1884, SEQ ID NO: 1667, SEQ ID NO: 1690, SEQ ID NO: 1813, SEQ ID NO: 1468, SEQ ID NO: 1470, SEQ ID NO: 1811, SEQ ID NO: 1874, SEQ ID NO: 1876, SEQ ID NO: 1825, SEQ ID NO: 1479, SEQ ID NO: 1488, SUBSTITUTE SHEET (RULE 26) WO 96/40893 PCT/US96/09122 -24- SEQ ID NO: 1528, SEQ ID NO: 1566, SEQ ID NO: 1683, SEQ ID NO: 1692, SEQ ID NO: 1718, SEQ ID NO: 1614, SEQ ID NO: 1519, SEQ ID NO: 1476, SEQ ID NO: 1493, SEQ ID NO: 1497, SEQ ID NO: 1507, SEQ ID NO: 1490, SEQ ID NO: 1523. SEQ ID NO: 1524, SEQ ID NO: 1543, SEQ ID NO: 1551, SEQ ID NO: 1553, SEQ ID NO: 1554, SEQ ID NO: 1555, SEQ ID NO: 1562, SEQ ID NO: 1570, SEQ ID NO: 1587, SEQ ID NO: 1588, SEQ ID NO: 1591, SEQ ID NO: 1593, SEQ ID NO: 1684, SEQ ID NO: 1689, SEQ ID NO: 1694, SEQ ID NO: 1696, SEQ ID NO: 1698, SEQ ID NO: 1700, SEQ ID NO: 1712, SEQ ID NO: 1720, SEQ ID NO: 1730, SEQ ID NO: 1735, SEQ ID NO: 1741, SEQ ID NO: 1748, SEQ ID NO: 1779, SEQ ID NO: 1821, SEQ ID NO: 1823, SEQ ID NO: 1828, SEQ ID NO: 1834, SEQ ID NO: 1835, SEQ ID NO: 1836, SEQ ID NO: 1839, SEQ ID NO: 1852, SEQ ID NO: 1853, SEQ ID NO: 1869, SEQ ID NO: 1871, SEQ ID NO: 1878, SEQ ID NO: 1521, SEQ ID NO: 1602, SEQ ID NO: 1627, SEQ ID NO: 1450, SEQ ID NO: 1457, SEQ ID NO: 1463, SEQ ID NO: 1469, SEQ ID NO: 1481, SEQ ID NO: 1484, SEQ ID NO: 1492, SEQ ID NO: 1500, SEQ ID NO: 1505, SEQ ID NO: 1508, SEQ ID NO: 1541, SEQ ID NO: 1548, SEQ ID NO: 1580, SEQ ID NO: 1590, SEQ ID NO: 1594, SEQ ID NO: 1603, SEQ ID NO: 1604, SEQ ID NO: 1606, SEQ ID NO: 1612, SEQ ID NO: 1613, SEQ ID NO: 1620, SEQ ID NO: 1621, SEQ ID NO: 1622, SEQ ID NO: 1631, SEQ ID NO: 1645, SEQ ID NO: 1646, SEQ ID NO: 1650, SEQ ID NO: 1651, SEQ ID NO: 1652, SEQ ID NO: 1653, SEQ ID NO: 1656, SEQ ID NO: 1763, SEQ ID NO: 1787, SEQ ID NO: 1800, SEQ ID NO: 1806, SEQ ID NO: 1810, SEQ ID NO: 1864, SEQ ID NO: 1877, SEQ ID NO: 1881, SEQ ID NO: 390, SEQ ID NO: 876, SEQ ID NO: 547, SEQ ID NO: 678, SEQ ID NO: 729, SEQ ID NO: 786, SEQ ID NO: 654, SEQ ID NO: 734, SEQ ID NO: 646, SEQ ID NO: 522, SEQ ID NO: 696, SEQ ID NO: 807, SEQ ID NO: 683, SEQ ID NO: 790, SEQ ID NO: 763, SEQ ID NO: 806, SEQ ID NO: 799, SEQ ID NO: 434, SEQ ID NO: 743, SEQ ID NO: 804, SEQ ID NO: 733, SEQ ID NO: 826, SEQ ID NO: 562, SEQ ID NO: 420, SEQ ID NO: 664, SEQ ID NO: 850, SEQ ID NO: 857, SEQ ID NO: 861, SEQ ID NO: 872, SEQ ID NO: 544, SEQ ID NO: 830, SEQ ID NO: 446, SEQ ID NO: 397, SEQ ID NO: 699, SEQ ID NO: 459, SEQ ID NO: 509, SEQ ID NO: 818, SEQ ID NO: 488, SEQ ID NO: 438, SEQ ID NO: 831, SEQ ID NO: 667, SEQ ID NO: 429, SEQ ID NO: 680, SEQ ID NO: 597, SEQ ID NO: 460, SEQ ID NO: 709, SEQ ID NO: 822, SEQ ID NO: 466, SEQ ID NO: 584, SEQ ID NO: 388, SEQ ID NO: 631, SEQ ID NO: 787, SEQ ID NO: 532, SEQ ID NO: 619, SEQ ID NO: 723, SEQ ID NO: 641, SEQ ID NO: 698, SEQ ID NO: 630, SEQ ID NO: 869, SEQ ID NO: 601, SEQ ID NO: 415, SEQ ID NO: 542, SEQ ID NO: 704, SEQ ID NO: 572, SEQ ID NO: 467, SEQ ID NO: 399, SEQ ID NO: 579, SEQ ID NO: 739, SEQ ID NO: 849, SEQ ID NO: 824, SEQ ID NO: 871, SEQ ID NO: 547, SEQ ID NO: 633, SEQ ID NO: 695, SEQ ID NO: 405, SEQ ID NO: 394, SEQ ID NO: 761, SEQ ID NO: 574, SEQ ID NO: 596, SEQ ID NO: 832, SEQ ID NO: 651, SEQ ID NO: 867, SEQ ID NO: 614, SEQ ID NO: 401, SEQ ID NO: 393, SEQ ID NO: 413, SEQ ID NO: 835, SEQ ID NO: 863, SEQ SUBSTITUTE SHEET (RULE 26) WO 96/40893 PCT/US96/09122 ID NO: 458, SEQ ID NO: 701, SEQ ID NO: 531, SEQ ID NO: 550, SEQ ID NO: 439, SEQ ID NO: 516, SEQ ID NO: 802, SEQ ID NO: 581, SEQ ID NO: 535, SEQ ID NO: 578, SEQ ID NO: 492, SEQ ID NO: 858, SEQ ID NO: 720, SEQ ID NO: 813, SEQ ID NO: 426, SEQ ID NO: 834, SEQ ID NO: 609, SEQ ID NO: 489, SEQ ID NO: 480, SEQ ID NO: 406, SEQ ID NO: 392, SEQ ID NO: 456, SEQ ID NO: 707, SEQ ID NO: 533, SEQ ID NO: 728, SEQ ID NO: 769, SEQ ID NO: 671, SEQ ID NO: 602, SEQ ID NO: 618, SEQ ID NO: 618, SEQ ID NO: 682, SEQ ID NO: 524, SEQ ID NO: 802, SEQ ID NO: 785, SEQ ID NO: 457, SEQ ID NO: 781, SEQ ID NO: 473, SEQ ID NO: 384, SEQ ID NO: 726, SEQ ID NO: 817, SEQ ID NO: 498, SEQ ID NO: 436, SEQ ID NO: 815, SEQ ID NO: 856, SEQ ID NO: 650, SEQ ID NO: 844, SEQ ID NO: 580, SEQ ID NO: 783, SEQ ID NO: 416, SEQ ID NO: 741, SEQ ID NO: 442, SEQ ID NO: 803, SEQ ID NO: 520, SEQ ID NO: 566, SEQ ID NO: 557, SEQ ID NO: 706, SEQ ID NO: 710, SEQ ID NO: 487, SEQ ID NO: 603, SEQ ID NO: 472, SEQ ID NO: 476, SEQ ID NO: 770, SEQ ID NO: 841, SEQ ID NO: 768, SEQ ID NO: 839, SEQ ID NO: 560, SEQ ID NO: 796, SEQ ID NO: 483, SEQ ID NO: 634, SEQ ID NO: 445, SEQ ID NO: 853, SEQ ID NO: 525, SEQ ID NO: 798, SEQ ID NO: 549, SEQ ID NO: 836, SEQ ID NO: 589, SEQ ID NO: 760, SEQ ID NO: 462, SEQ ID NO: 789, SEQ ID NO: 507, SEQ ID NO: 828, SEQ ID NO: 866, SEQ ID NO: 754, SEQ ID NO: 730, SEQ ID NO: 617, SEQ ID NO: 455, SEQ ID NO: 873, SEQ ID NO: 435, SEQ ID NO: 766, SEQ ID NO: 793, SEQ ID NO: 742, SEQ ID NO: 599, SEQ ID NO: 854, and SEQ ID NO: 632.
In one embodiment, the H. pylori cytoplasmic polypeptide or a fragment thereof is an H. pylori polypeptide or a fragment thereof involved in energy conversion selected from the group consisting of SEQ ID NO: 1598, SEQ ID NO: 1739, SEQ ID NO: 1775, SEQ ID NO: 1814, SEQ ID NO: 390, SEQ ID NO: 876, SEQ ID NO: 547, and SEQ ID NO: 678.
In another embodiment, the H. pylori cytoplasmic polypeptide or a fragment thereof is an H. pylori polypeptide or a fragment thereof involved in amino acid metabolism selected from the group consisting of SEQ ID NO: 1448, SEQ ID NO: 1466, SEQ ID NO: 1535, SEQ ID NO: 1545, SEQ ID NO: 1550, SEQ ID NO: 1680, SEQ ID NO: 1701, SEQ ID NO: 1719, SEQ ID NO: 1744, SEQ ID NO: 1790, SEQ ID NO: 1859, SEQ ID NO: 1880, SEQ ID NO: 1885, SEQ ID NO: 1679, SEQ ID NO: 1482, SEQ ID NO: 1485, SEQ ID NO: 1459, SEQ ID NO: 729, SEQ ID NO: 786, SEQ ID NO: 654, SEQ ID NO: 734, SEQ ID NO: 646, SEQ ID NO: 522, SEQ ID NO: 696, SEQ ID NO: 807, SEQ ID NO: 683, SEQ ID NO: 790, SEQ ID NO: 763, SEQ ID NO: 806, SEQ ID NO: 799, SEQ ID NO: 434, SEQ ID NO: 743, SEQ ID NO: 804, and SEQ ID NO: 733.
In yet another embodiment, the H. pylori cytoplasmic polypeptide or a fragment thereof is an H. pylori polypeptide or a fragment thereof involved in nucleotide metabolism selected from the group consisting of SEQ ID NO: 1512, SEQ ID NO: 1515, SEQ ID NO: 1642, SEQ ID NO: 1668, SEQ ID NO: 1816, SEQ ID NO: 1845, SEQ ID NO: 1865, SEQ ID NO: 1866, SEQ ID NO: 1886, SEQ ID NO: 1509, SEQ ID NO: 1510, SEQ ID NO: 826, SUBSTITUTE SHEET (RULE 26) WO 96/40893 PCT/US96/09122 -26- SEQ ID NO: 562, SEQ ID NO: 420, SEQ ID NO: 664, SEQ ID NO: 850, SEQ ID NO: 857, SEQ ID NO: 861, SEQ ID NO: 872, SEQ ID NO: 544, SEQ ID NO: 830, and SEQ ID NO: 446.
In yet a further embodiment, the H pylori cytoplasmic polypeptide or a fragment thereof is an H. pylori polypeptide or a fragment thereof involved in carbohydrate metabolism selected from the group consisting of SEQ ID NO: 1531, SEQ ID NO: 1579, SEQ ID NO: 1584, SEQ ID NO: 1662, SEQ ID NO: 1703, SEQ ID NO: 1704, SEQ ID NO: 1737, SEQ ID NO: 1740, SEQ ID NO: 1742, SEQ ID NO: 1754, SEQ ID NO: 1847, SEQ ID NO: 1447, SEQ ID NO: 397, SEQ ID NO: 699, SEQ ID NO: 459, SEQ ID NO: 509, SEQ ID NO: 818, SEQ ID NO: 488, SEQ ID NO: 438, SEQ ID NO: 831, SEQ ID NO: 667, SEQ ID NO: 429, SEQ ID NO: 680, and SEQ ID NO: 597.
In another embodiment, the H. pylori cytoplasmic polypeptide or a fragment thereof is an H. pylori polypeptide or a fragment thereof involved in cofactor metabolism selected from the group consisting of SEQ ID NO: 1546, SEQ ID NO: 1607, SEQ ID NO: 1609, SEQ ID NO: 1610, SEQ ID NO: 1728, SEQ ID NO: 1489, SEQ ID NO: 460, SEQ ID NO: 709, SEQ ID NO: 822, SEQ ID NO: 466, SEQ ID NO: 584, and SEQ ID NO: 388.
In another embodiment, the H. pylori cytoplasmic polypeptide or a fragment thereof is an H. pylori polypeptide or a fragment thereof involved in lipid metabolism selected from the group consisting of SEQ ID NO: 1708, SEQ ID NO: 1808, SEQ ID NO: 1887, SEQ ID NO: 631, SEQ ID NO: 787, and SEQ ID NO: 532.
In another embodiment, the H pylori cytoplasmic polypeptide or a fragment thereof is an H. pylori polypeptide or a fragment thereof involved in mRNA translation and ribosome biogenesis selected from the group consisting of SEQ ID NO: 1498, SEQ ID NO: 1506, SEQ ID NO: 1592, SEQ ID NO: 1678, SEQ ID NO: 1778, SEQ ID NO: 1863, SEQ ID NO: 619, SEQ ID NO: 723, SEQ ID NO: 641, SEQ ID NO: 698, SEQ ID NO: 630, and SEQ ID NO: 869.
In another embodiment, the H. pylori cytoplasmic polypeptide or a fragment thereof is an H. pylori polypeptide or a fragment thereof involved in genome replication, transcription, recombination and repair selected from the group consisting of SEQ ID NO: 1454, SEQ ID NO: 1538, SEQ ID NO: 1567, SEQ ID NO: 1581, SEQ ID NO: 1583, SEQ ID NO: 1636, SEQ ID NO: 1639, SEQ ID NO: 1649, SEQ ID NO: 1669, SEQ ID NO: 1695, SEQ ID NO: 1757, SEQ ID NO: 1776, SEQ ID NO: 1848, SEQ ID NO: 1849, SEQ ID NO: 1858, SEQ ID NO: 1884, SEQ ID NO: 601, SEQ ID NO: 415, SEQ ID NO: 542, SEQ ID NO: 704, SEQ ID NO: 572, SEQ ID NO: 467, SEQ ID NO: 399, SEQ ID NO: 579, SEQ ID NO: 739, SEQ ID NO: 849, SEQ ID NO: 824, SEQ ID NO: 871, SEQ ID NO: 547, SEQ ID NO: 633, SEQ ID NO: 695, SEQ ID NO: 405, SEQ ID NO: 394, and SEQ ID NO: 761.
In another embodiment, the H pylori cytoplasmic polypeptide or a fragment thereof is an H pylori polypeptide or a fragment thereof involved in outer membrane or cell wall SUBSTITUTE SHEET (RULE 26) WO 96/40893 PCT/US96/09122 -27biosynthesis selected from the group consisting of SEQ ID NO: 1667, SEQ ID NO: 1690, SEQ ID NO: 1813, SEQ ID NO: 1468, SEQ ID NO: 1470, SEQ ID NO: 1811, SEQ ID NO: 574, SEQ ID NO: 596, SEQ ID NO: 832, SEQ ID NO: 651, SEQ ID NO: 867, SEQ ID NO: 614, SEQ ID NO: 401, and SEQ ID NO: 393.
In yet another embodiment, the H pylori cytoplasmic polypeptide or a fragment thereof is an H pylori chaperone polypeptide or a fragment thereof selected from the group consisting of SEQ ID NO: 1874, SEQ ID NO: 1876, SEQ ID NO: 1825, SEQ ID NO: 413, SEQ ID NO: 835, and SEQ ID NO: 863.
Particularly preferred is a purified or isolated H pylori secreted or periplasmic polypeptide or a fragment thereof, wherein the polypeptide is selected from the group consisting of SEQ ID NO: 1455, SEQ ID NO: 1589, SEQ ID NO: 1518, SEQ ID NO: 1529, SEQ ID NO: 1765, SEQ ID NO: 1770, SEQ ID NO: 1829, SEQ ID NO: 1556, SEQ ID NO: 1565, SEQ ID NO: 1569, SEQ ID NO: 1571, SEQ ID NO: 1574, SEQ ID NO: 1578, SEQ ID NO: 1663, SEQ ID NO: 1674, SEQ ID NO: 1676, SEQ ID NO: 1697, SEQ ID NO: 1699, SEQ ID NO: 1710, SEQ ID NO: 1715, SEQ ID NO: 1716, SEQ IDNO: 1732, SEQ ID NO: 1736, SEQ ID NO: 1745, SEQ ID NO: 1749, SEQ ID NO: 1750, SEQ ID NO: 1766, SEQ ID NO: 1767, SEQ ID NO: 1768, SEQ ID NO: 1769, SEQ ID NO: 1795, SEQ ID NO: 1802, SEQ ID NO: 1804, SEQ ID NO: 1824, SEQ ID NO: 1831, SEQ ID NO: 1838, SEQ ID NO: 1840, SEQ ID NO: 1844, SEQ ID NO: 1862, SEQ ID NO: 1879, SEQ ID NO: 1882, SEQ ID NO: 1890, SEQ ID NO: 1494, SEQ ID NO: 1634, SEQ ID NO: 1635, SEQ ID NO: 1647, SEQ ID NO: 1648, SEQ ID NO: 1654, SEQ ID NO: 1446, SEQ ID NO: 1449, SEQ ID NO: 1452, SEQ ID NO: 1473, SEQ ID NO: 1474, SEQ ID NO: 1480, SEQ ID NO: 1491, SEQ ID NO: 1502, SEQ ID NO: 1513, SEQ ID NO: 1605, SEQ ID NO: 1771, SEQ ID NO: 1526, SEQ ID NO: 1557, SEQ ID NO: 1560, SEQ ID NO: 1585, SEQ ID NO: 1672, SEQ ID NO: 1677, SEQ ID NO: 1686, SEQ ID NO: 1752, SEQ ID NO: 1762, SEQ ID NO: 1777, SEQ ID NO: 1792, SEQ ID NO: 1805, SEQ ID NO: 1815, SEQ ID NO: 1817, SEQ ID NO: 1827, SEQ ID NO: 1842, SEQ ID NO: 1846, SEQ ID NO: 1896, SEQ ID NO: 1530, SEQ ID NO: 1637, SEQ ID NO: 1461, SEQ ID NO: 1467, SEQ ID NO: 1623, SEQ ID NO: 1625, SEQ ID NO: 530, SEQ ID NO: 708, SEQ ID NO: 414, SEQ ID NO: 694, SEQ ID NO: 703, SEQ ID NO: 721, SEQ ID NO: 749, SEQ ID NO: 685, SEQ ID NO: 444, SEQ ID NO: 606, SEQ ID NO: 582, SEQ ID NO: 621, SEQ ID NO: 868, SEQ ID NO: 666, SEQ ID NO: 408, SEQ ID NO: 538, SEQ ID NO: 573, SEQ ID NO: 639, SEQ ID NO: 668, SEQ ID NO: 524, SEQ ID NO: 422, SEQ ID NO: 819, SEQ ID NO: 611, SEQ ID NO: 674, SEQ ID NO: 577, SEQ ID NO: 663, SEQ ID NO: 558, SEQ ID NO: 794, SEQ ID NO: 564, SEQ ID NO: 592, SEQ ID NO: 814, SEQ ID NO: 398, SEQ ID NO: 767, SEQ ID NO: 425, SEQ ID NO: 659, SEQ ID NO: 517, SEQ ID NO: 539, SEQ ID NO: 475, SEQ ID NO: 615, SEQ ID NO: 665, SEQ ID NO: 607, SEQ ID NO: 598, SEQ ID NO: 759, SEQ ID NO: 752, SEQ ID NO: 595, SEQ ID NO: 686, SEQ ID NO: 528, SEQ ID NO: 705, SEQ ID NO: 828, SEQ ID SUBSTITUTE SHEET (RULE 26) WO 96/40893 PCT/US96/09122 -28- NO: 403, SEQ ID NO: 561, SEQ ID NO: 500, SEQ ID NO: 491, SEQ ID NO: 846, SEQ ID NO: 732, SEQ ID NO: 778, SEQ ID NO: 751, SEQ ID NO: 744, SEQ ID NO: 504, SEQ ID NO: 419, SEQ ID NO: 792, SEQ ID NO: 825, SEQ ID NO: 756, SEQ ID NO: 519, SEQ ID NO: 870, SEQ ID NO: 777, SEQ ID NO: 808, SEQ ID NO: 506, SEQ ID NO: 864, SEQ ID NO: 655, SEQ ID NO: 407, SEQ ID NO: 427, SEQ ID NO: 774, SEQ ID NO: 797, SEQ ID NO: 688, SEQ ID NO: 815, SEQ ID NO: 718, SEQ ID NO: 859, SEQ ID NO: 775, SEQ ID NO: 874, SEQ ID NO: 543, SEQ ID NO: 878, SEQ ID NO: 594, SEQ ID NO: 610, and SEQ ID NO: 600.
Particularly preferred is a purified or isolated H. pylori surface or membrane polypeptide or a fragment thereof, wherein the polypeptide is selected from the group consisting of SEQ ID NO: 1511, SEQ ID NO: 1561, SEQ ID NO: 1563, SEQ ID NO: 1681, SEQ ID NO: 1711, SEQ ID NO: 1731, SEQ ID NO: 1743, SEQ ID NO: 1747, SEQ ID NO: 1758, SEQ ID NO: 1893, SEQ ID NO: 1895, SEQ ID NO: 1573, SEQ ID NO: 1705, SEQ ID NO: 1707, SEQ ID NO: 1723, SEQ ID NO: 1726, SEQ ID NO: 1760, SEQ ID NO: 1764, SEQ ID NO: 1798, SEQ ID NO: 1803, SEQ ID NO: 1807, SEQ ID NO: 1889, SEQ ID NO: 1892, SEQ ID NO: 1460, SEQ ID NO: 1477, SEQ ID NO: 1499, SEQ ID NO: 1514, SEQ ID NO: 1641, SEQ ID NO: 1534, SEQ ID NO: 1564, SEQ ID NO: 1673, SEQ ID NO: 1746, SEQ ID NO: 1794, SEQ ID NO: 1843, SEQ ID NO: 1894, SEQ ID NO: 1536, SEQ ID NO: 1544, SEQ ID NO: 1568, SEQ ID NO: 1572, SEQ ID NO: 1582, SEQ ID NO: 1738, SEQ ID NO: 1891, SEQ ID NO: 1660, SEQ ID NO: 1793, SEQ ID NO: 1832, SEQ ID NO: 1841, SEQ ID NO: 1860, SEQ ID NO: 1486, SEQ ID NO: 1465, SEQ ID NO: 1539, SEQ ID NO: 1693, SEQ ID NO: 1629, SEQ ID NO: 1540, SEQ ID NO: 1791, SEQ ID NO: 1525, SEQ ID NO: 1558, SEQ ID NO: 1655, SEQ ID NO: 1517, SEQ ID NO: 875, SEQ ID NO: 676, SEQ ID NO: 801, SEQ ID NO: 860, SEQ ID NO: 747, SEQ ID NO: 529, SEQ ID NO: 387, SEQ ID NO: 391, SEQ ID NO: 515, SEQ ID NO: 625, SEQ ID NO: 568, SEQ ID NO: 454, SEQ ID NO: 800, SEQ ID NO: 499, SEQ ID NO: 779, SEQ ID NO: 648, SEQ ID NO: 643, SEQ ID NO: 537, SEQ ID NO: 511, SEQ ID NO: 616, SEQ ID NO: 829, SEQ ID NO: 546, SEQ ID NO: 780, SEQ ID NO: 553, SEQ ID NO: 549, SEQ ID NO: 410, SEQ ID NO: 608, SEQ ID NO: 513, SEQ ID NO: 656, SEQ ID NO: 845, SEQ ID NO: 563, SEQ ID NO: 570, SEQ ID NO: 805, SEQ ID NO: 851, SEQ ID NO: 423, SEQ ID NO: 810, SEQ ID NO: 604, SEQ ID NO: 636, SEQ ID NO: 757, SEQ ID NO: 412, SEQ ID NO: 816, SEQ ID NO: 771, SEQ ID NO: 418, SEQ ID NO: 662, SEQ ID NO: 512, SEQ ID NO: 679, SEQ ID NO: 605, SEQ ID NO: 421, SEQ ID NO: 552, SEQ ID NO: 576, SEQ ID NO: 571, SEQ ID NO: 725, SEQ ID NO: 565, SEQ ID NO: 717, SEQ ID NO: 536, SEQ ID NO: 647, SEQ ID NO: 501, SEQ ID NO: 838, SEQ ID NO: 428, SEQ ID NO: 494, SEQ ID NO: 479, SEQ ID NO: 711, SEQ ID NO: 722 ,SEQ ID NO: 645, SEQ ID NO: 670, SEQ ID NO: 746, SEQ ID NO: 493, SEQ ID NO: 540, SEQ ID NO: 612, SEQ ID NO: 629, SEQ ID NO: 484, SEQ ID NO: 485, SEQ ID NO: 486, SEQ ID NO: 433, SEQ ID NO: 385, and SEQ ID NO: 409.
SUBSTITUTE SHEET (RULE 26) WO 96/40893 PCT/US96/09122 -29- In one embodiment, the H pylori surface or membrane polypeptide or a fragment thereof is an H pylori polypeptide or a fragment thereof having at least one membrane spanning region selected from the group consisting of SEQ ID NO: 1511, SEQ ID NO: 1561, SEQ IDNO: 1563, SEQ ID NO: 1681, SEQ ID NO: 1711, SEQ ID NO: 1731, SEQ ID NO: 1743, SEQ ID NO: 1747, SEQ ID NO: 1758, SEQ ID NO: 1893, SEQ ID NO: 1895, SEQ ID NO: 875, SEQ ID NO: 676, SEQ ID NO: 801, SEQ ID NO: 860, SEQ ID NO: 747, SEQ ID NO: 529, SEQ ID NO: 387, SEQ ID NO: 391, SEQ ID NO: 515, SEQ ID NO: 625, SEQ ID NO: 568, SEQ ID NO: 454, SEQ ID NO: 800, SEQ ID NO: 499, SEQ ID NO: 779, and SEQ ID NO: 385.
In another embodiment, the H. pylori surface or membrane polypeptide or a fragment thereof is an H. pylori polypeptide or a fragment thereof having at least two membrane spanning regions selected from the group consisting of SEQ ID NO: 1573, SEQ ID NO: 1705, SEQ ID NO: 1707, SEQ ID NO: 1723, SEQ ID NO: 1726, SEQ ID NO: 1760, SEQ ID NO: 1764, SEQ ID NO: 1798, SEQ ID NO: 1803, SEQ ID NO: 1807, SEQ ID NO: 1889, SEQ ID NO: 1892, SEQ ID NO: 1460, SEQ ID NO: 1477, SEQ ID NO: 1499, SEQ ID NO: 1514, SEQ ID NO: 1641, SEQ ID NO: 648, SEQ ID NO: 643, SEQ ID NO: 537, SEQ ID NO: 511, SEQ ID NO: 616, SEQ ID NO: 829, SEQ ID NO: 546, SEQ ID NO: 780, SEQ ID NO: 553, SEQ ID NO: 549, SEQ ID NO: 410, SEQ ID NO: 608, SEQ ID NO: 513, SEQ ID NO: 656, SEQ ID NO: 845, SEQ ID NO: 563, SEQ ID NO: 570, SEQ ID NO: 805, and SEQ ID NO: 851.
In yet another embodiment, the H. pylori surface or membrane polypeptide or a fragment thereof is an H. pylori polypeptide or a fragment thereof having at least three membrane spanning regions selected from the group consisting of SEQ ID NO: 1534, SEQ ID NO: 1564, SEQ ID NO: 1673, SEQ ID NO: 1746, SEQ ID NO: 1794, SEQ ID NO: 1843, SEQ ID NO: 1894, SEQ ID NO: 423, SEQ ID NO: 810, SEQ ID NO: 604, SEQ ID NO: 636, SEQ ID NO: 757, SEQ ID NO: 412, and SEQ ID NO: 816.
In yet a further embodiment, the H pylori surface or membrane polypeptide or a fragment thereof is an H. pylori polypeptide or a fragment thereof having at least four membrane spanning regions selected from the group consisting of SEQ ID NO: 1536, SEQ ID NO: 1544, SEQ ID NO: 1568, SEQ ID NO: 1572, SEQ ID NO: 1582, SEQ ID NO: 1738, SEQ ID NO: 1891, SEQ ID NO: 1660, SEQ ID NO: 771, SEQ ID NO: 418, SEQ ID NO: 662, SEQ ID NO: 512, SEQ ID NO: 679, SEQ ID NO: 605, SEQ ID NO: 421, SEQ ID NO: 552, SEQ ID NO: 576, SEQ ID NO: 571.
In another embodiment, the H. pylori surface or membrane polypeptide or a fragment thereof is an H. pylori polypeptide or a fragment thereof having at least five membrane spanning regions selected from the group consisting of SEQ ID NO: 1793, SEQ ID NO: 1832, SEQ ID NO: 1841, SEQ ID NO: 1860, SEQ ID NO: 1486, SEQ ID NO: 725, SEQ ID NO: 565, SEQ ID NO: 717, SEQ ID NO: 536, SEQ ID NO: 647, and SEQ ID NO: 409.
SUBSTITUTE SHEET (RULE 26) WO 96/40893 PCT/US96/09122 In another embodiment, the H pylori surface or membrane polypeptide or a fragment thereof is an H pylori polypeptide or a fragment thereof having at least six membrane spanning regions selected from the group consisting of SEQ ID NO: 1465, SEQ ID NO: 1539, SEQ ID NO: 1693, SEQ ID NO: 1629, SEQ ID NO: 501, SEQ ID NO: 838, SEQ ID NO: 428, SEQ ID NO: 494, SEQ ID NO: 479, SEQ ID NO: 711, and SEQ ID NO: 722.
In yet another embodiment, the H pylori surface or membrane polypeptide or a fragment thereof is an H. pylori polypeptide or a fragment thereof having at least seven membrane spanning regions selected from the group consisting of SEQ ID NO: 1540, SEQ ID NO: 1791, SEQ ID NO: 1525, SEQ ID NO: 1558, SEQ ID NO: 1655, SEQ ID NO: 1517, SEQ ID NO: 645, SEQ ID NO: 670, SEQ ID NO: 746, SEQ ID NO: 493, SEQ ID NO: 540, SEQ ID NO: 612, SEQ ID NO: 629, SEQ ID NO: 484, SEQ ID NO: 485, SEQ ID NO: 486, and SEQ ID NO: 433.
In another aspect, the invention pertains to any individual H. pylori polypeptide member or nucleic acid encoding such a member from the above-identified groups of H.
pylori polypeptides.
In another aspect, the invention features nucleic acids capable of binding mRNA of H. pylori. Such nucleic acid is capable of acting as antisense nucleic acid to control the translation of mRNA of H pylori. A further aspect features a nucleic acid which is capable of binding specifically to an H pylori nucleic acid. These nucleic acids are also referred to herein as complements and have utility as probes and as capture reagents.
In another aspect, the invention features an expression system comprising an open reading frame corresponding to H. pylori nucleic acid. The nucleic acid further comprises a control sequence compatible with an intended host. The expression system is useful for making polypeptides corresponding to H pylori nucleic acid.
In another aspect, the invention features a cell transformed with the expression system to produce H pylori polypeptides.
In another aspect, the invention features a method of generating antibodies against H. pylori polypeptides which are capable of binding specifically to H. pylori polypeptides.
Such antibodies have utility as reagents for immunoassays to evaluate the abundance and distribution ofH. pylori-specific antigens.
In another aspect, the invention features a method of generating vaccines for immunizing an individual against H. pylori. The method includes: immunizing a subject with an H. pylori polypeptide, a surface or secreted polypeptide, or active portion thereof, and a pharmaceutically acceptable carrier. Such vaccines have therapeutic and prophylactic utilities.
In another aspect, the invention provides a method for generating a vaccine comprising a modified immunogenic H. pylori polypeptide, a surface or secreted polypeptide, or active portion thereof, and a pharmacologically acceptable carrier.
SUBSTITUTE SHEET (RULE 26) WO 96/40893 PCT/US96/09122 -31- In another aspect, the invention features a method of evaluating a compound, e.g. a polypeptide, a fragment of a host cell polypeptide, for the ability to bind an H pylori polypeptide. The method includes: contacting the candidate compound with an H pylori polypeptide and determining if the compound binds or otherwise interacts with an H pylori polypeptide. Compounds which bind H pylori are candidates as activators or inhibitors of the bacterial life cycle. These assays can be performed in vitro or in vivo.
In another aspect, the invention features a method of evaluating a compound, e.g. a polypeptide, a fragment of a host cell polypeptide, for the ability to bind an H pylori nucleic acid, DNA or RNA. The method includes: contacting the candidate compound with an H pylori nucleic acid and determining if the compound binds or otherwise interacts with an H. pylori polypeptide. Compounds which bind H pylori are candidates as activators or inhibitors of the bacterial life cycle. These assays can be performed in vitro or in vivo.
The invention features H pylori polypeptides, preferably a substantially pure preparation of an H pylori polypeptide, or a recombinant H pylori polypeptide. In preferred embodiments: the polypeptide has biological activity; the polypeptide has an amino acid sequence at least 60%, 70%, 80%, 90%, 95%, 98%, or 99% identical to an amino acid sequence of the invention contained in the Sequence Listing, preferably it has about 65% sequence identity with an amino acid sequence of the invention contained in the Sequence Listing, and most preferably it has about 92% to about 99% sequence identity with an amino acid sequence of the invention contained in the Sequence Listing; the polypeptide has an amino acid sequence essentially the same as an amino acid sequence of the invention contained in the Sequence Listing; the polypeptide is at least 5, 10, 20, 100, or 150 amino acid residues in length; the polypeptide includes at least 5, preferably at least 10, more preferably at least 20, more preferably at least 50, 100, or 150 contiguous amino acid residues of the invention contained in the Sequence Listing. In yet another preferred embodiment, the amino acid sequence which differs in sequence identity by about 7% to about 8% from the H pylori amino acid sequences of the invention contained in the Sequence Listing is also encompassed by the invention.
In preferred embodiments: the H pylori polypeptide is encoded by a nucleic acid of the invention contained in the Sequence Listing, or by a nucleic acid having at least 80%, 90%, 95%, 98%, or 99% homology with a nucleic acid of the invention contained in the Sequence Listing.
In a preferred embodiment, the subject H pylori polypeptide differs in amino acid sequence at 1, 2, 3, 5, 10 or more residues from a sequence of the invention contained in the Sequence Listing. The differences, however, are such that the H pylori polypeptide exhibits an H pylori biological activity, the H. pylori polypeptide retains a biological activity of a naturally occurring H pylori enzyme.
SUBSTITUTE SHEET (RULE 26) WO 96/40893 PCT/US96/09122 -32- In preferred embodiments, the polypeptide includes all or a fragment of an amino acid sequence of the invention contained in the Sequence Listing; fused, in reading frame, to additional amino acid residues, preferably to residues encoded by genomic DNA 5' or 3' to the genomic DNA which encodes a sequence of the invention contained in the Sequence Listing.
In yet other preferred embodiments, the H pylori polypeptide is a recombinant fusion protein having a first H. pylori polypeptide portion and a second polypeptide portion, a second polypeptide portion having an amino acid sequence unrelated to H pylori. The second polypeptide portion can be, any of glutathione-S-transferase, a DNA binding domain, or a polymerase activating domain. In preferred embodiment the fusion protein can be used in a two-hybrid assay.
Polypeptides of the invention include those which arise as a result of alternative transcription events, alternative RNA splicing events, and alternative translational and postranslational events.
The invention also encompasses an immunogenic component which includes an H pylori polypeptide in an immunogenic preparation; the immunogenic component being capable of eliciting an immune response specific for the H pylori polypeptide, a humoral response, an antibody response, or a cellular response. In preferred embodiments, the immunogenic component comprises at least one antigenic determinant from a polypeptide of the invention contained in the Sequence Listing.
In another aspect, the invention provides a substantially pure nucleic acid having a nucleotide sequence which encodes an H. pylori polypeptide. In preferred embodiments: the encoded polypeptide has biological activity; the encoded polypeptide has an amino acid sequence at least 60%, 70%, 80%, 90%, 95%, 98%, or 99% homologous to an amino acid sequence of the invention contained in the Sequence Listing; the encoded polypeptide has an amino acid sequence essentially the same as an amino acid sequence of the invention contained in the Sequence Listing; the encoded polypeptide is at least 5, 10, 20, 50, 100, or 150 amino acids in length; the encoded polypeptide comprises at least 5, preferably at least more preferably at least 20, more preferably at least 50, 100, or 150 contiguous amino acids of the invention contained in the Sequence Listing.
In preferred embodiments: the nucleic acid of the invention is that contained in the Sequence Listing; the nucleic acid is at least 60%, 70%, 80%, 90%, 95%, 98%, or 99% homologous with a nucleic acid sequence of the invention contained in the Sequence Listing.
In a preferred embodiment, the encoded H pylori polypeptide differs by amino acid substitution, addition or deletion of at least one amino acid residue) in amino acid sequence at 1, 2, 3, 5, 10 or more residues, from a sequence of the invention contained in the Sequence Listing. The differences, however, are such that: the H pylori encoded SUBSTITUTE SHEET (RULE 26) WO 96/40893 PCT/US96/09122 -33polypeptide exhibits a H pylori biological activity, the encoded H pylori enzyme retains a biological activity of a naturally occurring H pylori.
In preferred embodiments, the encoded polypeptide includes all or a fragment of an amino acid sequence of the invention contained in the Sequence Listing; fused, in reading frame, to additional amino acid residues, preferably to residues encoded by genomic DNA or 3' to the genomic DNA which encodes a sequence of the invention contained in the Sequence Listing.
In preferred embodiments, the subject H pylori nucleic acid will include a transcriptional regulatory sequence, e.g. at least one of a transcriptional promoter or transcriptional enhancer sequence, operably linked to the H pylori gene sequence, to render the H pylori gene sequence suitable for expression in a recombinant host cell.
In yet a further preferred embodiment, the nucleic acid which encodes an H pylori polypeptide of the invention, hybridizes under stringent conditions to a nucleic acid probe corresponding to at least 8 consecutive nucleotides of the invention contained in the Sequence Listing; more preferably to at least 12 consecutive nucleotides of the invention contained in the Sequence Listing; more preferably to at least 20 consecutive nucleotides of the invention contained in the Sequence Listing; more preferably to at least 40 consecutive nucleotides of the invention contained in the Sequence Listing.
In a preferred embodiment, the nucleic acid encodes a peptide which differs by at least one amino acid residue from the sequences of the invention contained in the Sequence Listing.
In a preferred embodiment, the nucleic acid differs by at least one nucleotide from a nucleotide sequence of the invention contained in the Sequence Listing which encodes amino acids of the invention contained in the Sequence Listing.
In another aspect, the invention encompasses: a vector including a nucleic acid which encodes an H pylori polypeptide or an H pylori polypeptide variant as described herein; a host cell transfected with the vector; and a method of producing a recombinant H.
pylori polypeptide or H pylori polypeptide variant; including culturing the cell, in a cell culture medium, and isolating the H. pylori or H pylori polypeptide variant, from the cell or from the cell culture medium.
In another aspect, the invention features, a purified recombinant nucleic acid having at least 50%, 60%, 70%, 80%, 90%, 95%, 98%, or 99% homology with a sequence of the invention contained in the Sequence Listing.
The invention also provides a probe or primer which includes a substantially purified oligonucleotide. The oligonucleotide includes a region of nucleotide sequence which hybridizes under stringent conditions to at least 10 consecutive nucleotides of sense or antisense sequence of the invention contained in the Sequence Listing, or naturally occurring mutants thereof. In preferred embodiments, the probe or primer further includes a label group attached thereto. The label group can be, a radioisotope, a fluorescent SUBSTITUTE SHEET (RULE 26) WO 96/40893 PCT/US96/09122 -34compound, an enzyme, and/or an enzyme co-factor. Preferably the oligonucleotide is at least 10 and less than 20, 30, 50, 100, or 150 nucleotides in length.
The invention further provides nucleic acids, RNA or DNA, encoding a polypeptide of the invention. This includes double stranded nucleic acids as well as coding and antisense single strands.
The H. pylori strain, from which genomic sequences have been sequenced, has been deposited in the American Type Culture Collection(ATCC 55679) as strain HP-J99.
Included in the invention are: allelic variations; natural mutants; induced mutants; proteins encoded by DNA that hybridizes under high or low stringency conditions to a nucleic acid which encodes a polypeptide of the invention contained in the Sequence Listing (for definitions of high and low stringency see Current Protocols in Molecular Biology, John Wiley Sons, New York, 1989, 6.3.1 6.3.6, hereby incorporated by reference); and, polypeptides specifically bound by antisera to H. pylori polypeptides, especially by antisera to an active site or binding domain of H. pylori polypeptide. The invention also includes fragments, preferably biologically active fragments. These and other polypeptides are also referred to herein as H. pylori polypeptide analogs or variants.
Putative functions have been determined for several of the H. pylori polypeptides of the invention, as shown in Table 1.
Accordingly, uses of the claimed H pylori polypeptides in these identified functions are also within the scope of the invention.
In addition, the present invention encompasses H pylori polypeptides characterized as shown in Table 1 below, including: H. pylori cell envelope proteins, H pylori periplasmic/secreted proteins, H. pylori cytoplasmic proteins, and other H. pylori surface and membrane proteins. Members of these groups were identified by BLAST homology searches and by searches for secretion signal or transmembrane protein motifs.
(Polypeptides in the same row of Table 1, rows 1 and 3, or rows 2 and 4, are related to one another as described in Table 3 below.) SUBSTITUTE SHEET (RULE 26) WO 96/40893 PCT/US96/09122 TABLE 1 TABLE OF FUNCTIONAL GROUPS nt aa nt aa ORF Name SeqID SeqID ORF Name SeqID SeqID Row 1 2 3 4 A. CELL ENVELOPE A. 1. Flagella-associated OlgplO4Olorfl 1020 1471 26588588.aa 217 660 OlgplO4OlorfS 1021 1472 26588588.aa 217 660 02ae1I1612orf2l 1036 1487 6288949.aa 367 855 O2celO2l3orf7 1050 1501 22692187.aa 911 534 02ge20116orf34 1071 1522 29454837.aa 944 675 O4gell17l3orfS 1101 1552 11 71928.aa, 18 404 O4gell1713orfS 1101 1552 21699087.aa 107 518 05ep20322orf1 1 1135 1586 16219090.aa 894 464 l2ge2O3O~orfll1 1276 1727 29298130.aa 943 672 06cp20302orf12 1150 1601 25525277.aa 203 640 07ge20415orf27 1187 1638 19557055.aa 85 490 07ge20415orf27 1187 1638 36111066.aa 290 755 07ge31107orf2 1192 1643 104792.aa 5 389 29zp10241orf6 1361 1812 24882763.aa 199 635 hp2e10911orf5 1379 1830 917152.aa 992 877 hp3el11l22orfl 1399 1850 25478375.aa 934 637 hp3ell1l68orf2 1403 1854 16984442.aa 899 477 hpel11l22orf5 1400 1851 3942217.aa 302 772 07ge20415orf34 1189 1640 26380318.aa 215 658 A.2. Inner membrane proteins Olcell10l6orfl 1002 1453 O9aplI4O6orfI4 1213 1664 16131887.aa 893 463 O9aplIl4O6orfl 5 1214 1665 6093906.aa 984 852 O9aplIl4O6orf5 1215 1666 2082012.aa 97 503 1lIcelIl6O3orfl 6 1234 1685 1204418.aa 22 411 1lIcelIl6O3orfl 6 1234 1685 14455461.aa 49 441 11lcell16O3orf25 1236 1687 4035783.aa 309 782 1lIcelIl6O3orf6 1237 1688 23915877.aa. 150 575 09cp10502orf22 1224 1675 30730068.aa 240 691 09cp10502orf22 1224 1675 3385833.aa 957 724 11lgplIO9O4orf29 1251 1702 14713512.aa 57 452 12ap10324orf2 1262 1713 10353192.aa 2 386 O6cp2O3O2orflO 1149 1600 203192.aa. 92 497 09ap20802orf5 1220 1671 32704686.aa 255 712 11lgel0309orfl 4 1240 1691 24222885.aa. 164 591 IlIgelIO3O9orfl 4 1240 1691 2548562.aa 201 638 O6gplO4O9orf7 1164 1615 34666680.aa. 278 740 06gp10409orf8 1165 1616 3203142.aa 245 697 SUBSTITUTE SHEET (RULE 26) WO 96/40893 PCTIUS96/09122 -36hp3elll68orf29 1404 1855 23853165.aa 921 569 06cplI18orf6 1144 1595 16412593.aa 896 470 06cpI1118orf6 1144 1595 32236462.aa 248 700 07ee20513orf28 1182 1633 24132293.aa 159 586 07ee20513orf28 1182 1633 486075.aa 979 823 06epl0306orf12 1157 1608 24651083.aa 194 627 06epl0306orf3 1160 1611 24651083.aa 194 627 06eplO306orf3 1160 1611 30089217.aa 946 684 13epl2003orf2O 1300 1751 23493756.aa 916 551 14gel0705orfl1 1321 1772 17086587.aa 76 478 14gel0705orfl1 1321 1772 21486677.aa 905 508 14gel0705orfl1 1321 1772 23468781.aa 914 545 14gel0705orfl1 1321 1772 24708129.aa 931 628 14gpI1820orfl3 1323 1774 14494077.aa 50 443 14gpI1820orfl3 1323 1774 3242337.aa 250 702 14gpl1820orf13 1323 1774 3962777.aa 969 776 14gpl2Ol5orfl2 1329 1780 15824052.aa 66 461 14gpl2Ol5orfl2 1329 1780 34489543.aa 275 737 14gpl2Ol5orfl6 1332 1783 4698838.aa 330 809 27zel0351orfl7 1345 1796 25605166.aa 204 642 29zp10241orfl4 1358 1809 9776562.aa 383 879 hplpl3947orf2 1375 1826 3953143.aa 303 773 hp4pl1352orf4 1417 1868 16406265.aa 70 468 13apl1517orf2O 1283 1734 5267037.aa 983 842 16ae10113orfl 1335 1786 423131.aa 972 788 hplpl3922orf22 1368 1819 24611590.aa 929 624 07eel l620orf2 1179 1630 423131.aa 972 788 12ael0622orf9 1255 1706 259665.aa 936 644 12ael0622orf9 1255 1706 34097707.aa 267 727 12aell404orfl5 1258 1709 24806290.aa 197 631 02celO213orfl4 1044 1495 14645905.aa 55 450 12gelO305orflS 1273 1724 14642202.aa 54 448 Olxe2l7l7orfl8 1024 1475 26261040.aa 210 653 A.3. Transporters 09ap20802orf27 1219 1670 20032561.aa 90 495 12gelO305orfl6 1274 1725 11132778.aa 15 400 09ael l601orfl4 1210 1661 23439633.aa 913 541 09aell601orfl4 1210 1661 29302003.aa 227 673 hp5ell726orf7 1422 1873 179677.aa 79 482 14ceI1113orfl 1302 1753 24609593.aa 191 622 14cpl0119orfl2 1308 1759 30662792.aa 238 689 14cpl0119orfl5 1310 1761 34427317.aa 274 736 14gpl2Ol5orfl4 1331 1782 12617677.aa 27 417 hp5el5440orfl6 1432 1883 33203192.aa 258 716 hp5el5440orfl6 1432 1883 36573502.aa 295 762 02ce1022orf7 1052 1503 1071890.aa 10 395 04ep10811orf4 1091 1542 24215.aa 160 587 SUBSTITUTE SHEET (RULE 26) WO 96/40893 PCTIUS96/09122 -37- 04ep10811orf4 1091 1542 289711.aa 225 669 hp5ell726orf4 1421 1872 36203402.aa 964 758 02ge20116orf28 1069 1520 24238762.aa 166 593 Olcell513orf2l 1005 1456 1464715.aa 56 451 Ocell513orf2l 1005 1456 4882763.aa 980 827 01cel l618orfl0 1007 1458 207817.aa 903 502 06gpll202orf7 1166 1617 33399142.aa 261 719 07cp21714orfl3 1177 1628 16406581.aa 71 469 07gpl1807orf25 1193 1644 3319687.aa 955 715 07gpl1807orf8 1206 1657 5875152.aa 361 847 07gpl1807orf9 1207 1658 14714687.aa 58 453 14ce20219orfl 1304 1755 22441050.aa 114 527 14ce20219orf2 1305 1756 26258562.aa 940 652 27zelO351orfl8 1346 1797 35345228.aa 960 745 27zel0351orf24 1348 1799 23728388.aa 144 567 27zel0351orf29 1350 1801 5878208.aa 362 848 02aell611orfl1 1032 1483 13726562.aa 40 430 02aell611orfll 1032 1483 35428912.aa 285 748 02cell022orf8 1053 1504 10723412.aa 11 396 02cell022orf8 1053 1504 24218968.aa 161 588 02cell022orf8 1053 1504 4455467.aa 974 795 03ee1215orf29 1081 1532 22265691.aa 111 523 05cpll911orf4l 1124 1575 4338438.aa 316 791 hp2pl0625orf28 1382 1833 32952.aa 257 714 hp5pl5641orfi2 1437 1888 17787558.aa 78 481 12apl0324orf3 1263 1714 3906712.aa 966 765 A.4. Outer membrane proteins 07ap8O6OIorf8 1173 1624 5083193.aa 352 837 hp3elll68orf3O 1405 1856 4960952.aa 981 833 hp3plO156orfl2 1406 1857 24104558.aa 158 585 hp4e13394orf2 1410 1861 7116626.aa 989 865 04cell617orf2 1086 1537 36126938.aa 963 764 14gel0705orf5 1322 1773 1431462.aa 48 440 14geIO705orf5 1322 1773 16225006.aa 68 465 12apl0324orf7 1266 1717 23531562.aa 135 555 13aelO712orf9 1282 1733 22379952.aa 910 526 12gelO305orfl 1271 1722 30478562.aa 236 687 12gelO305orfl 1271 1722 31250333.aa 241 692 07gp31516orf4 1208 1659 31262.aa 949 693 05cp20518orf33 1126 1577 29479681.aa 945 677 12apll614orf8 1270 1721 26054702.aa 207 649 12ge2O3O5orf2 1278 1729 4721061.aa 977 812 Other cell envelope proteins hp4pll1352orf9 1419 1870 4821082.ana 978 820 05cp20518orfD 1125 1576 978477.aa 994 880 07ee20513orfl4 1181 1632 24220627.aa 163 590 hp4pl 1352orf2 1416 1867 32705252.aa 256 713 SUBSTITUTE SHEET (RULE 26) WO 96/40893 WO 9640893PCTIUS96/09122 -38hp4p113 52orf2 1416 1867 35445843.aa 287 750 04gelIl7l3orfll1 1096 1547 24427340.aa 184 613 O3eell12l5orf3O 1082 1533 1416312.aa 45 437 06cp1I1I722orfl 5 1146 1597 23535937.aa 136 556 O6cplIl722orfl 5 1146 1597 26366312.aa 214 657 06cp1I1722orf12 1145 1596 114505.aa 16 402 05ae20220orf32 1108 1559 2461062.aa 192 623 06cp1I1722orf21 1148 1599 6828218.aa 373 862 l6aelO5O8orfl3 1337 1788 14642217.aa 892 449 16ae10508orfl4 1338 1789 30703183.aa 239 690 hp5e12982orfl4 1424 1875 1365943.aa 34 424 0 1ae2200l orf2 1000 1451 4826401.aa 340 821 Olxe2l7l7orfS 1027 1478 1385937.aa 41 432 Olxe2l7l7orfS 1027 1478 4714375.aa 332 811 07ce10203orf22 1175 1626 23526667.aa 134 554 l4gpl2Ol~orfl3 1330 1781 4698838.aa 330 809 B. CYTOPLASAMIC PROTEINS B. 1. Proteins involved in energy conversion 06cp1I1722orfl 6 1147 1598 10553192.aa 882 390 l3eelO2l6orf55 1288 1739 914087.aa 382 876 14gp1I1820orf20 1324 1775 23475342.aa 130 547 hplIplIl244orf7 1363 1814 29500075.aa 230 678 B.2. Proteins involved in amino acid metabolism Olael2O2lorfl 997 1448 34109763.aa 269 729 0O1eel1162l1orf6 1015 1466 4177212.aa 312 786 O3ge3llO6orfl 1084 1535 26301059.aa 211 654 O4ep7l4O3orfl 5 1094 1545 34194093.aa 959 734 04ge1 1713orf37 1099 1550 25992137.aa 938 646 09gp10903orf3 1229 1680 21976637.aa 110 522 11lgplIO9O4orf27 1250 1701 31681556.aa 244 696 l2apl1l6l4orf4 1268 1719 45914063.aa 328 807 l3eel2Ol6orflO 1293 1744 30082267.aa 235 683 l6aelO5O8orf2l 1339 1790 429192.aa 315 790 hp3plO349orfl6 1408 1859 36594167.aa 296 763 15211 orf22 1429 1880 4578469.aa 976 806 hp5el544Oorfl9 1434 1885 4492217.aa 321 799 09cp10713orf29 1228 1679 1408.aa 43 434 O2ae11611orfl 1031 1482 35269000.aa 281 743 O2ae Il6l2orfl 3 1034 1485 4570262.aa 326 804 Olcell16l8orfl 8 1008 1459 34189716.aa 272 733 B.3. Proteins involved in nucleotide, metabolism O2cp2O82l orflO0 1061 1512 4882652.aa 344 826 O2ep3O6O7orflO 1064 1515 23598962.aa 139 562 O7ge2O4l~orf6 1191 1642 12897656.aa 30 420 O9ap2O8O2orfl 1217 1668 2738378.aa 220 664 hplpl3852orf5 1365 1816 598933.aa 364 850 hp3ellO024orf24 1394 1845 6517040.aa 369 857 SUBSTITUTE SHEET (RULE 26) WO 96/40893 WO 9640893PCT/US96/09122 hp4e14535orf3 1414 1865 677088.aa. 372 861 hp4el4535orf4 1415 1866 867183.aa 991 872 hp5el544Oorf2l 1435 1886 23442642.aa. 128 544 02cp1I1822orf22 1058 1509 4895327.aa 347 830 02cp1 1822orf26 1059 1510 14574201.aa. 52 446 BA4 Proteins involved in carbohydrate metabolism O3eell12l5orf26 1080 1531 10737627.aa 12 397 05cp20518orf5 1128 1579 32144532.aa 247 699 05cp2O~l8orf64 1133 1584 15807794.aa 64 459 O9ae11601orf3 1211 1662 2149041.aa 101 509 11lgplIl422orfl 1252 1703 4787562.aa 338 818 11lgplIl422orf2 1253 1704 19541302.aa 83 488 13ee10216orf43 1286 1737 14257751.aa 46 438 l3eelO2l6orfS6 1289 1740 4897177.aa 348 831 l3eelO2l6orf9 1291 1742 2855006.aa. 223 667 l4cell15l9orf2 1303 1754 13723593.aa 39 429 hp3ellO6Oorfll 1396 1847 29557266.aa 232 680 0O1ael1142l1orfl 996 1447 24300682.aa 168 597 Proteins involved in cofactor metabolism O4gelO8l6orf2 1095 1546 1581937.aa 65 460 O6eelIO7O9orfS 1156 1607 3261306.aa 952 709 O6eplO3O6orfl3 1158 1609 485375.aa 341 822 O6eplO3O6orfl4 1159 1610 16251627.aa 69 466 l2ge2O3O~orfl4 1277 1728 24089437.aa 924 584 02ae1I1612orf26 1038 1489 10407625.aa 4 388 B.6. Proteins involved in lipid metabolism l2aelIl4O4orfI 4 1257 1708 24806290.aa. 197 631 29zp10241orf11 1357 1808 422937.aa 313 787 hp~elIS44Oorf22 1436 1887 22667967.aa 119 532 B.7. Proteins involved in mRNA translation and ribosome biogenesis O2celO2l3orf2 1047 1498 24500088.aa 188 619 O2cpl 14O4orfll1 1055 1506 33601578.aa. 956 723 O6celO~l~orf4 1141 1592 25595387.aa 935 641 09cp10713orf28' 1227 1678 32036462.aa 246 698 l4gplIl820orfS 1327 1778 24803280.aa 196 630 hp4el4S22orfll1 1412 1863 785437.aa 376 869 B.8. Proteins involved in genome replication, transcription, recombination& repair Olcell10l6orfl4 1003 1454 24396937.aa. 172 601 04ce1I1617orf27 1087 1538 12520952.aa 25 415 O5apliSO05orfi 1116 1567 23440814.aa 126 542 05cp20518orf56 1130 1581 32431687.aa 951 704 05cp20518orf63 1132 1583 23880087.aa 147 572 O7gel115O4orf4 1185 1636 16305252.aa 895 467 07ge20415orf30 1188 1639 10745275.aa 14 399 O07gpll18O7orf35 1198 1649 24036302.aa 154 579 SUBSTITUTE SHEET (RULE 26) WO 96/40893 WO 9640893PCTIUS96/09122 09ap20802orf22 1218 1669 34574062.aa 277 739 O9ap2O8O2orf22 1218 1669 5879160.aa 363 849 11lge10309orf5 1 1244 1695 487750.aa 342 824 l4ce2l~l6orfl 1306 1757 85786.aa. 378 871 14gp1 1820orf27 1325 1776 23475342.aa. 130 547 hp3elIlO6Oorf2 1397 1848 24818802.aa, 198 633 hp3e Il06Oorf9 1398 1849 3166040.aa 243 695 hp3plOl56orfg 1407 1858 11719687.aa 19 405 hp~el544Oorfl8 1433 1884 10677187.aa 9 394 hp5el544Oorfl8 1433 1884 36523442.aa 761 B.9. Proteins involved in outer membrane or cell wall biosynthesis 09apI1406orfS 1216 1667 23912807.aa 149 574 O9aplIl4O6orf8 1216 1667 24298127.aa, 167 596 11lep12011orf9 1239 1690 495312.aa 349 832 29zp10241orf7 1362 1813 26197187.aa 209 651 Olep3O52Oorfl6 1017 1468 7225666.aa, 990 867 01ep30520orf27 1019 1470 24441412.aa 185 614 Olep3O52Oorf27 1019 1470 11253.aa 883 401 29zp 1024 1orf4 1360 1811 10675632.aa 8 393 B. 10. Chaperones hp5e12982offl3 1423 1874 12343763.aa 887 413 hp~e15211orflO0 1425 1876 50253.aa 350 835 hplpl3947orfl 1374 1825 6845425.aa 987 863 B. 11 Other cytoplasmic proteins Olxe2l7l7orf9 1028 1479 156587.aa 63 458 02ae1I1612orf25 1037 1488 32422343.aa 249 701 O3eelIl2l5orflO0 1077 1528 22542803.aa 118 531 05ae20220orf99 1115 1566 23492181.aa 132 550 11lce10917orfl 4 1232 1683 14313885.aa 47 439 11lgel0309orfl 5 1241 1692 21647676.aa 106 516 l2aplIl6l4orf2 1267 1718 4562712.aa 324 802 O6gel10l11 orfl 5 1163 1614 24070250.aa 155 581 02ge20116orf22 1068 1519 22704567.aa 121 535 02ge20116orf22 1068 1519 24003758.aa 153 578 02ge20116orf22 1068 1519 19626250.aa 87 492 02cp1I1404orf9 1056 1507 6517192.aa 986 858 O3aelO5l6orfll1 1072 1523 33476715.aa 262 720 O3aelIO0l6orfll1 1072 1523 4726503.aa 333 813 O3ap2l82OorflO0 1073 1524 13673328.aa 36 426 O4ep7l4O3orflO0 1092 1543 50062.aa 982 834 04gp1 1213orf36 1102 1553 24414687.aa 180 609 O4gp11213 orf6O 1103 1554 19556290.aa. 84 489 O5aelO3O7orfl 1104 1555 17497107.aa 900 480 05ae20220orf54 1111 1562 1179838.aa 20 406 O5cp11911orflI1 1119 1570 10664078.aa 7 392 9Olorf2O 1136 1587 15039062.aa 61 456 SUBSTITUTE SHEET (RULE 26) WO 96/40893 PCT/US96/09122 -41- 05gpll901orf24 1137 1588 32600912.aa 253 707 06aell405orfl0 1140 1591 22687687.aa 120 533 06ceI1002orf2 1142 1593 34099062.aa 268 728 1Ice10917orf9 1233 1684 391313.aa 299 769 11cpl2006orfl7 1238 1689 291700.aa 942 671 11gel0309orf25 1243 1694 24406401.aa 173 602 11gel0309orf56 1245 1696 24495312.aa 187 618 11gel0309orf66 1247 1698 24495312.aa 187 618 11gpl0904orfl2 1249 1700 29844512.aa 234 682 l2aell404orf9 1261 1712 22303918.aa 112 524 l2apl1614orf6 1269 1720 4562712.aa 324 802 12ge20305orf30 1279 1730 4095342.aa 971 785 13apl1517orf3l 1284 1735 15126875.aa 62 457 13eel0216orf82 1290 1741 4035262.aa 308 781 13eel2016orf24 1297 1748 16459375.aa 74 473 14gpl2Ol5orfl 1328 1779 10009666.aa 1 384 hplpl3922orf3O 1370 1821 34089087.aa 266 726 hplpl3939orfl3 1372 1823 4766691.aa 337 817 hp2el09llorf25 1377 1828 2035936.aa 93 498 hp2plO625orf3O 1383 1834 1411681.aa 44 436 hp2pl0625orf7 1384 1835 4740887.aa 335 815 hp2pl0625orfE 1385 1836 6495137.aa 368 856 hp3elO349orfl8 1388 1839 260941.aa 208 650 hp3elll68orfl4 1401 1852 5325005.aa 358 844 hp3elll68orfl5 1402 1853 24039587.aa 923 580 hp4pll352orf8 1418 1869 4040928.aa 310 783 hp4pl3402orfl 1420 1871 1256885.aa 26 416 hp5el5211orfl5 1427 1878 35156938.aa 279 741 02ge20116orf33 1070 1521 14480927.aa 890 442 06cp20302orf8 1151 1602 4569693.aa 325 803 07cel l409orf4 1176 1627 21742157.aa 109 520 01ael2021orf8 999 1450 23646885.aa 143 566 Olcell513orf24 1006 1457 23539006.aa 918 557 01cpll71Oorf27 1012 1463 32595137.aa 252 706 Oep3O520orf2O 1018 1469 32627125.aa 953 710 02aell211orfl9 1030 1481 19537968.aa 902 487 02aell611orf5 1033 1484 24407533.aa 174 603 02cel114orfl 1041 1492 16440842.aa 73 472 02cel0213orf32 1049 1500 16839562.aa 898 476 02cell220orf2 1054 1505 3930468.aa 300 770 02cp11721orfl3 1057 1508 5265957.aa 356 841 04ep0811orfl 1090 1541 3907042.aa 298 768 04ge1713orf27 1097 1548 5111308.aa 354 839 05cp2O5l8orf5O 1129 1580 23573294.aa 138 560 06aelI020orf2 1139 1590 4486092.aa 319 796 06cell002orf8 1143 1594 194415.aa 80 483 06cp3O6O3orfl1 1152 1603 24824087.aa 933 634 SUBSTITUTE SHEET (RULE 26) WO 96/40893 WO 9640893PCT/US96/09122 -42- 06ee1I0207orf2 1153 1604 14572133.aa 891 445 O6eelIO7O9orfl 7 1155 1606 6136430.aa 366 853 O6eplIlIlO8orf2O 1161 1612 22370182.aa 113 525 O6gel10l1l5orfl 2 1162 1613 4491093.aa 320 798 O7apllIllIlorf3 1169 1620 23490686.aa 915 549 O7ap8O6Ol orflO0 1170 1621 5078593.aa 351 836 07ap80601 orfl 2 1171 1622 24219012.aa 162 589 O7ee2O5l3orfl 1180 1631 36520792.aa 965 760 07gpl 1807orf28 1194 1645 16100038.aa 67 462 07gp1 1807orf29 1195 1646 42683.aa 314 789 07gp 11807orf3 8 1199 1650 214812.aa 904 507 O7gpll18O7orf4l 1200 1651 4882842.aa 345 828 07gp1I1I807orf42 1201 1652 719606.aa 374 866 07gp1 1807orf44 1202 1653 35949212.aa 962 754 O7gpll18O7orfS4 1205 1656 34161500.aa 270 730 l4cplO923orfl 1312 1763 24492192.aa 186 617 l6aelOSO8orflO 1336 1787 14864452.aa 60 455 27zelO35lorf25 1349 1800 875042.aa 379 873 29gpl10 1l9orf6 1355 1806 14094816.aa 889 435 29zp 10241 orf1 8 1359 1810 3906937.aa 967 766 hp4e14535orf2 1413 1864 43490713.aa 973 793 hp~e15211orfl 3 1426 1877 35163962.aa 280 742 e15211orf29 1430 1881 24329712.aa 170 599 625277.aa 985 854 24816915.aa 932 632 C. SECRETED OR PERIPLASMIC PROTEINS C. 1. Secreted or periplasmic proteins Olcell10l6offl9 1004 1455 22460468.aa 117 530 O5gpll19Olorf25 1138 1589 32609403.aa 254 708 O2ge2OlI6orf2O 1067 1518 12505125.aa 24 '414 5 1078 1529 3157067.aa 242 694 14cp10923orf3 1314 1765 3242952.aa 950 703 l4eelIl217orfl 1319 1770 33595708.aa 263 721 l4eelIl2l7orfl 1319 1770 35442513.aa 286 749 hp2e10911orf3O0 1378 1829 30100332.aa 947 685 05ae20220orfl24 1105 1556 14570443.aa 51 4 05ae20220orf92 1114 1565 24410643.aa 177 606 O5ap2l2I6orf7 1118 1569 24078837.aa 156 582 O5cp11911orfl2 1120 1571 24609431.aa 190 621 O5cpl1911orf27 1123 1574 783432.aa 375 868 O5cp2O5l8orf4l 1127 1578 2843912.aa 222 666 O9aelIl6Olorf4 1212 1663 11876471.aa 21 408 O9cplO5O2orfl7 1223 1674 23438887.aa 912 538 O9cplO7l3orf25 1225 1676 23912707.aa 148 573 11lge10309orf63 1246 1697 25501501.aa 202 639 11lgel0309orf9 1248 1699 289077.aa 224 668 l2aelIl4O4orf3 1259 1710 22303918.aa 112 524 SUBSTITUTE SHEET (RULE 26) WO 96/40893 WO 9640893PCT/US96/09122 -43- 13eeI1021orf5 1298 1749 23705.aa 3 2 12aee121orf5 1299 1750 23564012.aa 137 58 14cpIO12orf4 13815 1766 244100.aa 18 794 l3apl 1l1lorf6 1316 1736 293612.aa 141 64 l4eel0308orfl5 1317 1768 243058.aa 15 592 14ee10308orf5 1318 1769 472089.aa 334 814 l3eeplOl~orf8 1344 1750 1074296.aa 137 398 27zelO93lorf5 1315 1802 391096.aa 297 767 2l~ l111l1orfl 1353 1804 1367157.aa 351 54 hplplO393orfS 1317 178 2423058.aa 16 59 hpeell8S8orfS9 1318 1831 42184.aa 908 517 hp 1el1347orfl7 1387 1838 23439055.aa 124 39 hpze10349orf24 1389 180 1663.aa 27 757 hpge1102I4or122 1393 1844 244751.aa 927 615 hple11024orf22 1393 1844 27428.aa 216 659 hp~el1394orf5 1411 1862 24411011.aa 178 607 hp~elS3llorfl 148 1879 2343890.aa 169 539 hp~e15276orf14 1319 1882 663436.aa 293 475 hp3 I164orf2 139 1890 3458776.aa 929 715 hpcelO124orfll 1043 1844 27428.aa 926 Opgel13 3O4orf2 14183 18634 3283101aa 948 686 Opgel15211orf3l 1128 1635 244291.aa 115 528 h7p118276orf32 141 1647 326235436.aa 251 759 07gp11807or133 1139 168 458242.aa 345 852 07gp 1013orf481 103 1654 112618.aa 176 403 OlaelI4O04orfl 9953 1434 32358.aa 920 616 9984 1449 2045.aa 915 500 O7gl lO0lorf2 101 1642 196250.aa 861 491 Olgpll18l7orfl4 1022 1643 486909.aa 360 846 Olxel l8l7orfl2 1203 1474 17957.aa 271 73 OlaelIl1llorfl 1029 1480 23988.aa 970 778 OlaellOllorf4 1040 1449 35047183.aa 288 510 OlcelO5l6orfl 1051 14502 35336707aa 82 441 0l2208orfl2 102 1513 20836042.aa 981 504 02ap211211orfl2 102 1510312984420.aa 9 419 O2aeeIO7O1orfl6 114 1605 33708.aa 317 792 1320 1771 4882318.aa 343 825 C.2. Proteins likely to be secreted or periplasmic 03ap21820orf5 1075 1526 36131282.aa 291 756 05ae20220orf24 1106 1557 21720017.aa 108 519 O5ae2O22Oorf5O 1109 1560 80257.aa 377 870 05cp20518orf9 1134 1585 3964593.aa .,305 777 SUBSTITUTE SHEET (RULE 26) WO 96/40893 WO 9640893PCTIUS96/09122 -44- O5cp2O~l8orf9 1134 1585 4687507.aa 305 808 O9cplO5O2orfl4 1221 1672 2111040.aa 100 506 09cp10713orf26 1226 1677 7031343.aa 988 864 11 ce11603 orf22 1235 1686 26306340.aa 212 655 l4celIO72Oorf2 1301 1752 1181418.aa 884 407 l4cpl10l1l9orf7 1311 1762 1370202.aa 37 427 l4gplIl82Oorf4 1326 1777 3953952.aa 968 774 l6cp3OlO9orf6 1341 1792 4490717.aa 975 797 29gp 10l1l9orfS 1354 1805 30603402.aa 237 688 hplpll1256orf7 1364 1815 4740887.aa 335 815 hplp13868orf24 1366 1817 33397538.aa 260 718 hplpl4Ol3orf4 1376 1827 663530.aa 370 859 hp3elO24orfl6 1391 1842 20173437.aa 91 496 hp3elIlO24orfl 6 1391 1842 34573431.aa 276 738 hp3elIlO24orf6 1395 1846 4062813.aa 311 784 hp6plO723orf7 1445 1896 24406401.aa 173 602 O3eell1215orf2O 1079 1530 2150290.aa 102 510 07ge20415orf22 1186 1637 3958537.aa 304 775 0OIcelIl6l8orf2O 1010 1461 882827.aa 380 874 OleplO2l6orf6 1016 1467 23441078.aa 127 543 O7ap8O6Ol orfS 1172 1623 917200.aa 993 878 O4gell17l3orf35 1098 1549 24256572.aa 925 594 03ap21820orf9 1076 1527 24415917.aa 181 610 O7celO2O3orfl4 1174 1625 24395801.aa 171 600 D. OTHER SURFACE AND MEMBRANE PROTEINS D. 1. Proteins likely to contain a single membrane spanning region 02cp I1I822orf8 1060 1511 907827.aa 381 875 05ae20220orf51 1110 1561 29458178.aa 229 676 05ae20220orf6 1112 1563 4548792.aa 323 801 11lael1O305orf4 1230 1681 6696887.aa 371 860 12ae I1404orf8 1260 1711 35417942.aa 284 747 12ge20305orf35 1280 1731 22453166.aa 116 529 13ee I1718orf2 1292 1743 1038312.aa 3 387 13ee12016orfl9 1296 1747 10580417.aa 6 391 13eel2Ol6orfl9 1296 1747 21618785.aa 907 515 14ce21516orf3 1307 1758 24634750.aa 193 625 hp6plO723orf2O 1442 1893 23831562.aa 145 568 hp6plO723orfS 1444 1895 14726542.aa 59 454 O2celO2l3orfl 1042 1493 4531568.aa 322 800 02ae1 1612orf36 1039 1490 2040717.aa 94 499 O4gelIl7l3orf4l 1100 1551 3991067.aa 306 779 10037799.aa 881 385 D.2. Proteins likely to contain two membrane spans O5cpl191lorfl5 1122 1573 26052137.aa 939 648 12ae1I0622orfl 6 1254 1705 25925.aa 205 643 l2aelIl4O4orfl 2 1256 1707 23438840.aa 123 537 SUBSTITUTE SHEET (RULE 26) WO 96/40893 WO 9640893PCT/US96/09122 l2gelO3O5orflO 1272 1723 21503772.aa 906 511 l2gelO3O5orflO 1272 1723 24488537.aa 928 616 l2gelO3O5orf2l 1275 1726 489057.aa 346 829 l4cpl10l1l9orfl 4 1309 1760 23473437.aa 129 546 l4cp 10l1l9orfl 4 1309 1760 40339452.aa 307 780 14cp10923orf14 1313 1764 23515833.aa 133 553 27ze10351orf22 1347 1798 23486342.aa 131 548 27ze10351orf7 1352 1803 11924177.aa 886 410 29gpl10l1l9orf7 1356 1807 24413512.aa 179 608 hp~pl564lorfS 1438 1889 21563752.aa 104 513 hp6p IO723orfl 3 1441 1892 26351567.aa 213 656 0OIcelIl6l8orfl 9 1009 1460 55843.aa 359 845 Olxe2l7l7orf4O 1026 1477 23610905.aa 140 563 02ce10213orf23 1048 1499 23867207.aa 146 570 02cp20821 orf8 1063 1514 4572168.aa 327 805 07ge20415orf39 1190 1641 5993958.aa 365 851 D.3. Proteins likely to contain 3 membrane spanning regions O3gelO5O5orfl4 1083 1534 1364378.aa 33 423 05ae20220orf88 1113 1564 4708337.aa 331 810 O9cplIO0O2orfl 6 1222 1673 24409577.aa 175 604 13eeI2Ol6orfl8 1295 1746 25398250.aa 200 636 l6epl10l1l7orf7 1343 1794 36134661.aa 292 757 hp3 elIlO24orfl 7 1392 1843 1206675.aa 23 412 hp6p1I0723orf43 1443 1894 4744128.aa 336 816 DA4 Proteins likely to contain 4 membrane spanning regions O3xelIl2l5orfS 1085 1536 3933437.aa 301 771 04ep71403orfl 2 1093 1544 12694087.aa 28 418 O5aplIlSO0orflO0 1117 1568 26758437.aa 941 662 O5cp11911orfl 3 1121 1572 21511555.aa 103 512 O5cp11911orfl 3 1121 1572 29531590.aa 231 -679 O5cp2Ol8orf6l 1131 1582 24409641.aa 176 605 l3eelO216orfS 1287 1738 12969218.aa 31 421 l3eelO2l6orfS 1287 1738 23494043.aa 917 552 hp~pl564lorf9 1440 1891 23945317.aa 151 576 O9ael1160O1orfll1 1209 1660 23867687.aa 922 571 Proteins likely to contain 5 membrane spanning regions l6epl10l1l7orf6 1342 1793 hp2plO62Sorfl4 1381 1832 33986087.aa 265 725 hp3e10349orf25 1390 1841 23631317.aa 142 565 hp3p10349orf32 1409 1860 33218912.aa 259 717 O2aeI 6l2orfl 4 1035 1486 23437502.aa 122 536 25995917.aa 206 647 11878127.aa 885 409 D.6. Proteins likely to contain 6 membrane spanning regions 0O1cp1171Oorf34 1014 1465 2042312.aa 96 501 0O1cp1171Oorf34 1014 1465 5083577.aa 353 838 04ep10206orf22 1088 1539 13704718.aa 38 428 SUBSTITUTE SHEET (RULE 26) WO 96/40893 PCT/US96/09122 -46- 04ep10206orf22 1088 1539 20023400.aa 89 494 1 gel0309orfl8 1242 1693 17089217.aa 77 479 07cp21714orfl4 1178 1629 32663212.aa 954 711 07cp21714orfl4 1178 1629 3360130.aa 264 722 D.7. Proteins likely to contain 7 or more membrane spanning regions 04epl0206orf23 1089 1540 25976418.aa 937 645 04epl0206orf23 1089 1540 2915903.aa 226 670 16ael0508orf3 1340 1791 35360843.aa 283 746 03ap21820orfl3 1074 1525 197166.aa 88 493 03ap21820orfl3 1074 1525 234391.aa 125 540 03ap21820orfl3 1074 1525 24417212.aa 183 612 05ae20220orf31 1107 1558 24798427.aa 195 629 07gpl 1807orf49 1204 1655 19531291.aa 81 484 07gpl 1807orf49 1204 1655 19536375.aa 901 485 02ep30607orf31 1066 1517 19536458.aa 82 486 02ep30607orf31 1066 1517 13865928.aa 42 433 [In Table 1, "nt" represents nucleotide Seq. ID number and "aa" represents amino Seq. ID number] Definitions A purified or isolated polypeptide or a substantially pure preparation of a polypeptide are used interchangeably herein and, as used herein, mean a polypeptide that has been separated from other proteins, lipids, and nucleic acids with which it naturally occurs. Preferably, the polypeptide is also separated from substances, antibodies or gel matrix, polyacrylamide, which are used to purify it. Preferably, the polypeptide constitutes at least 10, 20, 50 70, 80 or 95% dry weight of the purified preparation.
Preferably, the preparation contains: sufficient polypeptide to allow protein sequencing; at least 1, 10, or 100 p.g of the polypeptide; at least 1, 10, or 100 mg of the polypeptide.
A purified preparation of cells refers to, in the case of plant or animal cells, an in vitro preparation of cells and not an entire intact plant or animal. In the case of cultured cells or microbial cells, it consists of a preparation of at least 10% and more preferably of the subject cells.
A purified or isolated or a substantially pure nucleic acid, a substantially pure DNA, (are terms used interchangeably herein) is a nucleic acid which is one or both of the following: not immediately contiguous with both of the coding sequences with which it is immediately contiguous one at the 5' end and one at the 3' end) in the naturallyoccurring genome of the organism from which the nucleic acid is derived; or which is substantially free of a nucleic acid with which it occurs in the organism from which the nucleic acid is derived. The term includes, for example, a recombinant DNA which is incorporated into a vector, into an autonomously replicating plasmid or virus, or into the genomic DNA of a prokaryote or eukaryote, or which exists as a separate molecule a cDNA or a genomic DNA fragment produced by PCR or restriction endonuclease treatment) independent of other DNA sequences. Substantiial pure DNA also includes a SUBSTITUTE SHEET (RULE 26) WO 96/40893 PCT/US96/09122 -47recombinant DNA which is part of a hybrid gene encoding additional H. pylori DNA sequence.
A "contig" as used herein is a nucleic acid representing a continuous stretch of genomic sequence of an organism.
An "open reading frame", also referred to herein as ORF, is a region of nucleic acid which encodes a polypeptide. This region may represent a portion of a coding sequence or a total sequence and can be determined from a stop to stop codon or from a start to stop codon.
As used herein, a "coding sequence" is a nucleic acid which is transcribed into messenger RNA and/or translated into a polypeptide when placed under the control of appropriate regulatory sequences. The boundaries of the coding sequence are determined by a translation start codon at the five prime terminus and a translation stop code at the three prime terminus. A coding sequence can include but is not limited to messenger RNA, synthetic DNA, and recombinant nucleic acid sequences.
A "complement" of a nucleic acid as used herein referes to an anti-parallel or antisense sequence that participates in Watson-Crick base-pairing with the original sequence.
A "gene product" is a protein or structural RNA which is specifically encoded by a gene.
As used herein, the term "probe" refers to a nucleic acid, peptide or other chemical entity which specifically binds to a molecule of interest. Probes are often associated with or capable of associating with a label. A label is a chemical moiety capable of detection.
Typical labels comprise dyes, radioisotopes, luminescent and chemiluminescent moieties, fluorophores, enzymes, precipitating agents, amplification sequences, and the like.
Similarly, a nucleic acid, peptide or other chemical entity which specifically binds to a molecule of interest and immobilizes such molecule is referred herein as a "capture ligand".
Capture ligands are typically associated with or capable of associating with a support such as nitro-cellulose, glass, nylon membranes, beads, particles and the like. The specificity of hybridization is dependent on conditions such as the base pair composition of the nucleotides, and the temperature and salt concentration of the reaction. These conditions are readily discernable to one of ordinary skill in the art using routine experimentation.
Homologous refers to the sequence similarity or sequence identity between two polypeptides or between two nucleic acid molecules. When a position in both of the two compared sequences is occupied by the same base or amino acid monomer subunit, if a position in each of two DNA molecules is occupied by adenine, then the molecules are homologous at that position. The percent of homology between two sequences is a function of the number of matching or homologous positions shared by the two sequences divided by the number of positions compared x 100. For example, if 6 of 10 of the positions in two sequences are matched or homologous then the two sequences are SUBSTITUTE SHEET (RULE 26) WO 96/40893 PCT/US96/09122 -48homologous. By way of example, the DNA sequences ATTGCC and TATGGC share homology. Generally, a comparison is made when two sequences are aligned to give maximum homology.
Nucleic acids are hybridizable to each other when at least one strand of a nucleic acid can anneal to the other nucleic acid under defined stringency conditions. Stringency of hybridization is determined by: the temperature at which hybridization and/or washing is performed; and the ionic strength and polarity of the hybridization and washing solutions. Hybridization requires that the two nucleic acids contain complementary sequences; depending on the stringency of hybridization, however, mismatches may be tolerated. Typically, hybridization of two sequences at high stingency (such as, for example, in a solution of 0.5X SSC, at 650 C) requires that the sequences be essentially completely homologous. Conditions of intermediate stringency (such as, for example, 2X SSC at 65 C) and low stringency (such as, for example 2X SSC at 550 require correspondingly less overall complementarity between the hybridizing sequences. (lX SSC is 0.15 M NaC1, 0.015 M Na citrate).
The terms peptides, proteins, and polypeptides are used interchangeably herein.
As used herein, the term "surface protein" refers to all surface accessible proteins, e.g. inner and outer membrane proteins, proteins adhering to the cell wall, and secreted proteins.
A polypeptide has H. pylori biological activity if it has one, two and preferably more of the following properties: if when expressed in the course of an H pylori infection, it can promote, or mediate the attachment of H pylori to a cell; it has an enzymatic activity, structural or regulatory function characteristic of an H pylori protein; or the gene which encodes it can rescue a lethal mutation in an H pylori gene. A polypeptide has biological activity if it is an antagonist, agonist, or super-agonist of a polypeptide having one of the above-listed properties.
A biologically active fragment or analog is one having an in vivo or in vitro activity which is characteristic of the H pylori polypeptides of the invention contained in the Sequence Listing, or of other naturally occurring H pylori polypeptides, one or more of the biological activities described herein. Especially preferred are fragments which exist in vivo, fragments which arise from post transcriptional processing or which arise from translation of alternatively spliced RNA's. Fragments include those expressed in native or endogenous cells as well as those made in expression systems, in CHO cells. Because peptides such as H pylori polypeptides often exhibit a range of physiological properties and because such properties may be attributable to different portions of the molecule, a useful H. pylori fragment or H pylori analog is one which exhibits a biological activity in any biological assay for H pylori activity. Most preferably the fragment or analog possesses 10%, preferably 40%, more preferably 60%, 70%, 80% or 90% or greater of the activity of H pylori, in any in vivo or in vitro assay.
SUBSTITUTE SHEET (RULE 26) WO 96/40893 PCT/US96/09122 -49- Analogs can differ from naturally occurring H. pylori polypeptides in amino acid sequence or in ways that do not involve sequence, or both. Non-sequence modifications include changes in acetylation, methylation, phosphorylation, carboxylation, or glycosylation. Preferred analogs include H. pylori polypeptides (or biologically active fragments thereof) whose sequences differ from the wild-type sequence by one or more conservative amino acid substitutions or by one or more non-conservative amino acid substitutions, deletions, or insertions which do not substantially diminish the biological activity of the H. pylori polypeptide. Conservative substitutions typically include the substitution of one amino acid for another with similar characteristics, substitutions within the following groups: valine, glycine; glycine, alanine; valine, isoleucine, leucine; aspartic acid, glutamic acid; asparagine, glutamine; serine, threonine; lysine, arginine; and phenylalanine, tyrosine. Other conservative substitutions can be made in view of the table below.
TABLE 2 CONSERVATIVE AMINO ACID REPLACEMENTS For Amino Acid Code Replace with any of Alanine A D-Ala, Gly, beta-Ala, L-Cys, D-Cys Arginine R D-Arg, Lys, D-Lys, homo-Arg, D-homo-Arg, Met, Ile, D-Met, D-Ile, Orn, D-Orn Asparagine N D-Asn, Asp, D-Asp, Glu, D-Glu, Gin, D-Gln Aspartic Acid D D-Asp, D-Asn, Asn, Glu, D-Glu, Gin, D-Gln Cysteine C D-Cys, S-Me-Cys, Met, D-Met, Thr, D-Thr Glutamine Q D-GIn, Asn, D-Asn, Glu, D-Glu, Asp, D-Asp Glutamic Acid E D-Glu, D-Asp, Asp, Asn, D-Asn, Gln, D-GIn Glycine G Ala, D-Ala, Pro, D-Pro, p-Ala, Acp Isoleucine I D-Ile, Val, D-Val, Leu, D-Leu, Met, D-Met Leucine L D-Leu, Val, D-Val, Leu, D-Leu, Met, D-Met Lysine K D-Lys, Arg, D-Arg, homo-Arg, D-homo-Arg, Met, D- Met, lie, D-Ile, Orn, D-Orn Methionine M D-Met, S-Me-Cys, lie, D-Ile, Leu, D-Leu, Val, D-Val Phenylalanine F D-Phe, Tyr, D-Thr, L-Dopa, His, D-His, Trp, D-Trp, Trans-3,4, or 5-phenylproline, cis-3,4, or SUBSTITUTE SHEET (RULE 26) WO 96/40893 PCT/US96/09122 Proline Serine Threonine Tyrosine Valine D-Pro, L-I-thioazolidine-4-carboxylic acid, D-or L-1oxazolidine-4-carboxylic acid D-Ser, Thr, D-Thr, allo-Thr, Met, D-Met, Met(O), D-Met(O), L-Cys, D-Cys D-Thr, Ser, D-Ser, allo-Thr, Met, D-Met, Met(O), D-Met(O), Val, D-Val D-Tyr, Phe, D-Phe, L-Dopa, His, D-His D-Val, Leu, D-Leu, lie, D-Ile, Met, D-Met Other analogs within the invention are those with modifications which increase peptide stability; such analogs may contain, for example, one or more non-peptide bonds (which replace the peptide bonds) in the peptide sequence. Also included are: analogs that include residues other than naturally occurring L-amino acids, D-amino acids or nonnaturally occurring or synthetic amino acids, [3 or y amino acids; and cyclic analogs.
As used herein, the term "fragment", as applied to an H. pylori analog, will ordinarily be at least about 20 residues, more typically at least about 40 residues, preferably at least about 60 residues in length. Fragments of H. pylori polypeptides can be generated by methods known to those skilled in the art. The ability of a candidate fragment to exhibit a biological activity of H. pylori polypeptide can be assessed by methods known to those skilled in the art as described herein. Also included are H. pylori polypeptides containing residues that are not required for biological activity of the peptide or that result from alternative mRNA splicing or alternative protein processing events.
An "immunogenic component" as used herein is a moiety, such as an H. pylori polypeptide, analog or fragment thereof, that is capable of eliciting a humoral and/or cellular immune response in a host animal.
An "antigenic component" as used herein is a moiety, such as an H pylori polypeptide, analog or fragment thereof, that is capable of binding to a specific antibody with sufficiently high affinity to form a detectable antigen-antibody complex.
As used herein, the term "transgene" means a nucleic acid (encoding, one or more polypeptides), which is partly or entirely heterologous, foreign, to the transgenic animal or cell into which it is introduced, or, is homologous to an endogenous gene of the transgenic animal or cell into which it is introduced, but which is designed to be inserted, or is inserted, into the cell's genome in such a way as to alter the genome of the cell into which it is inserted it is inserted at a location which differs from that of the natural gene or its insertion results in a knockout). A transgene can include one or more transcriptional regulatory sequences and any other nucleic acid, such as introns, that may be necessary for optimal expression of the selected nucleic acid, all operably linked to the selected nucleic acid, and may include an enhancer sequence.
SUBSTITUTE SHEET (RULE 26) WO 96/40893 PCT/US96/09122 -51- As used herein, the term "transgenic cell" refers to a cell containing a transgene.
As used herein, a "transgenic animal" is any animal in which one or more, and preferably essentially all, of the cells of the animal includes a transgene. The transgene can be introduced into the cell, directly or indirectly by introduction into a precursor of the cell, by way of deliberate genetic manipulation, such as by a process of transformation of competent cells or by microinjection or by infection with a recombinant virus. This molecule may be integrated within a chromosome, or it may be extrachromosomally replicating DNA.
The term "antibody" as used herein is intended to include fragments thereof which are specifically reactive with H. pylori polypeptides.
As used herein, the term "cell-specific promoter" means a DNA sequence that serves as a promoter, regulates expression of a selected DNA sequence operably linked to the promoter, and which effects expression of the selected DNA sequence in specific cells of a tissue. The term also covers so-called "leaky" promoters, which regulate expression of a selected DNA primarily in one tissue, but cause expression in other tissues as well.
Misexpression, as used herein, refers to a non-wild type pattern of gene expression.
It includes: expression at non-wild type levels, over or under expression; a pattern of expression that differs from wild type in terms of the time or stage at which the gene is expressed, increased or decreased expression (as compared with wild type) at a predetermined developmental period or stage; a pattern of expression that differs from wild type in terms of decreased expression (as compared with wild type) in a predetermined cell type or tissue type; a pattern of expression that differs from wild type in terms of the splicing size, amino acid sequence, post-transitional modification, or biological activity of the expressed polypeptide; a pattern of expression that differs from wild type in terms of the effect of an environmental stimulus or extracellular stimulus on expression of the gene, a pattern of increased or decreased expression (as compared with wild type) in the presence of an increase or decrease in the strength of the stimulus.
As used herein, "host cells" and other such terms denoting microorganisms or higher eukaryotic cell lines cultured as unicellular entities refers to cells which can become or have been used as recipients for a recombinant vector or other transfer DNA, and include the progeny of the original cell which has been transfected. It is understood by individuals skilled in the art that the progeny of a single parental cell may not necessarily be completely identical in genomic or total DNA compliment to the original parent, due to accident or deliberate mutation.
As used herein, the term "control sequence" refers to a nucleic acid having a base sequence which is recognized by the host organism to effect the expression of encoded sequences to which they are ligated. The nature of such control sequences differs depending upon the host organism; in prokaryotes, such control sequences generally include a SUBSTITUTE SHEET (RULE 26) WO 96/40893 PCT/US96/09122 -52promoter, ribosomal binding site, terminators, and in some cases operators; in eukaryotes, generally such control sequences include promoters, terminators and in some instances, enhancers. The term control sequence is intended to include at a minimum, all components whose presence is necessary for expression, and may also include additional components whose presence is advantageous, for example, leader sequences.
As used herein, the term "operably linked" refers to sequences joined or ligated to function in their intended manner. For example, a control sequence is operably linked to coding sequence by ligation in such a way that expression of the coding sequence is achieved under conditions compatible with the control sequence and host cell.
The metabolism of a substance, as used herein, means any aspect of the, expression, function, action, or regulation of the substance. The metabolism of a substance includes modifications, covalent or non-covalent modifications of the substance. The metabolism of a substance includes modifications, covalent or non-covalent modification, the substance induces in other substances. The metabolism of a substance also includes changes in the distribution of the substance. The metabolism of a substance includes changes the substance induces in the distribution of other substances.
A "sample" as used herein refers to a biological sample, such as, for example, tissue or fluid isloated from an individual (including without limitation plasma, serum, cerebrospinal fluid, lymph, tears, saliva and tissue sections) or from in vitro cell culture constituents, as well as samples from the environment.
The practice of the invention will employ, unless otherwise indicated, conventional techniques of chemistry, molecular biology, microbiology, recombinant DNA, and immunology, which are within the skill of the art. Such techniques are explained fully in the literature. See Sambrook, Fritsch, and Maniatis, Molecular Cloning; Laboratory Manual 2nd ed. (1989); DNA Cloning, Volumes I and II (D.N Glover ed. 1985); Oligonucleotide Synthesis Gait ed, 1984); Nucleic Acid Hybridization Hamines S.J. Higgins eds. 1984); the series, Methods in Enzymoloqy (Academic Press, Inc.), particularly Vol. 154 and Vol. 155 (Wu and Grossman, eds.) and PCR-A Practical Approach (McPherson, Quirke, and Taylor, eds., 1991).
I. Isolation of Nucleic Acids of H pvlori and Uses Therefor H pylori Genomic Sequence This invention provides nucleotide sequences of the genome of H pylori which thus comprises a DNA sequence library of H pylori genomic DNA. The detailed description that follows provides nucleotide sequences of H pylori, and also describes how the sequences were obtained and how ORFs and protein-coding sequences were identified.
Also described are methods of using the disclosed H pylori sequences in methods including diagnostic and therapeutic applications. Furthermore, the library can be used as a SUBSTITUTE SHEET (RULE 26) WO 96/40893 PCT/US96/09122 -53database for identification and comparison of medically important sequences in this and other strains of H. pylori.
To determine the genomic sequence of H. pylori, DNA was isolated from a strain of H. pylori (ATCC 55679) and mechanically sheared by nebulization to a median size of 2 kb. Following size fractionation by gel electrophoresis, the fragments were blunt-ended, ligated to adapter oligonucleotides, and cloned into each of 20 different pMPX vectors (Rice et al., abstracts of Meeting of Genome Mapping and Sequencing, Cold Spring Harbor, NY, 5/11-5/15, 1994, p. 225) to construct a series of "shotgun" subclone libraries.
DNA sequencing was achieved using multiplex sequencing procedures essentially as disclosed in Church et al., 1988, Science 240:185; U.S. Patents No. 4,942,124 and 5,149,625). DNA was extracted from pooled cultures and subjected to chemical or enzymatic sequencing. Sequencing reactions were resolved by electrophoresis, and the products were transferred and covalently bound to nylon membranes. Finally, the membranes were sequentially hybridized with a series of labelled oligonucleotides complimentary to "tag" sequences present in the different shotgun cloning vectors. In this manner, a large number of sequences could be obtained from a single set of sequencing reactions. The cloning and sequencing procedures are described in more detail in the Exemplification.
Individual sequence reads obtained in this manner were assembled using the FALCONTM program (Church et al., 1994, Automated DNA Sequencing and Analysis, J.C.
Venter, ed., Academic Press) and PHRAP Green, Abstracts of DOE Human Genome Program Contractor-Grantee Workshop V, Jan. 1996, p. 157). The average contig length was about 3-4 kb.
A variety of approaches are used to order the contigs so as to obtain a continuous sequence representing the entire H. pylori genome. Synthetic oligonucleotides are designed that are complementary to sequences at the end of each contig. These oligonucleotides may be hybridized to libaries of H. pylori genomic DNA in, for example, lambda phage vectors or plasmid vectors to identify clones that contain sequences corresponding to the junctional regions between individual contigs. Such clones are then used to isolate template DNA and the same oligonucleotides are used as primers in polymerase chain reaction (PCR) to amplify junctional fragments, the nucleotide sequence of which is then determined.
The H. pylori sequences were analyzed for the presence of open reading frames (ORFs) comprising at least 180 nucleotides. As a result of the analysis of ORFs based on stop-to-stop codon reads, it should be understood that these ORFs may not correspond to the ORF of a naturally-occurring H. pylori polypeptide. These ORFs may contain start codons which indicate the initiation of protein synthesis of a naturally-occurring H.
pyloripolypeptide. Such start codons within the ORFs provided herein can be identified by those of ordinary skill in the relevant art, and the resulting ORF and the encoded H pylori polypeptide is within the scope of this invention. For example, within the ORFs a codon SUBSTITUTE SHEET (RULE 26) WO 96/40893 PCT/US96/09122 -54such as AUG or GUG (encoding methionine or valine) which is part of the initiation signal for protein synthesis can be identified and the ORF modified to correspond to a naturallyoccurring H. pylori polypeptide. The predicted coding regions were defined by evaluating the coding potential of such sequences with the program GENEMARKTM (Borodovsky and Mclninch, 1993, Comp. Chem. 17:123).
Other H. pylori Nucleic Acids The nucleic acids of this invention may be obtained directly from the DNA of the above referenced H pylori strain by using the polymerase chain reaction (PCR). See "PCR, A Practical Approach" (McPherson, Quirke, and Taylor, eds., IRL Press, Oxford, UK, 1991) for details about the PCR. High fidelity PCR can be used to ensure a faithful DNA copy prior to expression. In addition, the authenticity of amplified products can be checked by conventional sequencing methods. Clones carrying the desired sequences described in this invention may also be obtained by screening the libraries by means of the PCR or by hybridization of synthetic oligonucleotide probes to filter lifts of the library colonies or plaques as known in the art (see, Sambrook et al., Molecular Cloning, A Laboratory Manual 2nd edition, 1989, Cold Spring Harbor Press, NY).
It is also possible to obtain nucleic acids encoding H. pylori polypeptides from a cDNA library in accordance with protocols herein described. A cDNA encoding an H pylori polypeptide can be obtained by isolating total mRNA from an appropriate strain.
Double stranded cDNAs can then be prepared from the total mRNA. Subsequently, the cDNAs can be inserted into a suitable plasmid or viral bacteriophage) vector using any one of a number of known techniques. Genes encoding H. pylori polypeptides can also be cloned using established polymerase chain reaction techniques in accordance with the nucleotide sequence information provided by the invention. The nucleic acids of the invention can be DNA or RNA. Preferred nucleic acids of the invention are contained in the Sequence Listing.
The nucleic acids of the invention can also be chemically synthesized using standard techniques. Various methods of chemically synthesizing polydeoxynucleotides are known, including solid-phase synthesis which, like peptide synthesis, has been fully automated in commercially available DNA synthesizers (See Itakura et al. U.S. Patent No. 4,598,049; Caruthers et al. U.S. Patent No. 4,458,066; and Itakura U.S. Patent Nos.
4,401,796 and 4.373,071, incorporated by reference herein).
Nucleic acids isolated or synthesized in accordance with features of the present invention are useful, by way of example, without limitation, as probes, primers, capture ligands. antisense genes and for developing expression systems for the synthesis of proteins and peptides corresponding to such sequences. As probes, primers, capture ligands and antisense agents, the nucleic acid normally consists of all or part (approximately twenty or more nucleotides for specificity as well as the ability to form stable hybridization products) SUBSTITUTE SHEET (RULE 26) WO 96/40893 PCTIUS96/09122 of the nucleic acids of the invention contained in the Sequence Listing. These uses are described in further detail below.
Probes A nucleic acid isolated or synthesized in accordance with the sequence of the invention contained in the Sequence Listing can be used as a probe to specifically detect H pylori. With the sequence information set forth in the present application, sequences of twenty or more nucleotides are identified which provide the desired inclusivity and exclusivity with respect to H pylori, and extraneous nucleic acids likely to be encountered during hybridization conditions. More preferably, the sequence will comprise at least twenty to thirty nucleotides to convey stability to the hybridization product formed between the probe and the intended target molecules.
Sequences larger than 1000 nucleotides in length are difficult to synthesize but can be generated by recombinant DNA techniques. Individuals skilled in the art will readily recognize that the nucleic acids, for use as probes, can be provided with a label to facilitate detection of a hybridization product.
Nucleic acid isolated and synthesized in accordance with the sequence of the invention contained in the Sequence Listing can also be useful as probes to detect homologous regions (especially homologous genes) of other Helicobacter species using appropriate stringency hybridization conditions as described herein.
Capture Ligand For use as a capture ligand, the nucleic acid selected in the manner described above with respect to probes, can be readily associated with a support. The manner in which nucleic acid is associated with supports is well known. Nucleic acid having twenty or more nucleotides in a sequence of the invention contained in the Sequence Listing have utility to separate H pylori nucleic acid from the nucleic acid of each other and other organisms.
Nucleic acid having twenty or more nucleotides in a sequence of the invention contained in the Sequence Listing can also have utility to separate other Helicobacter species from each other and from other organisms. Preferably, the sequence will comprise at least twenty nucleotides to convey stability to the hybridization product formed between the probe and the intended target molecules. Sequences larger than 1000 nucleotides in length are difficult to synthesize but can be generated by recombinant DNA techniques.
Primers Nucleic acid isolated or synthesized in accordance with the sequences described herein have utility as primers for the amplification of H pylori nucleic acid. These nucleic acids may also have utility as primers for the amplification of nucleic acids in other Helicobacter species. With respect to polymerase chain reaction (PCR) techniques, nucleic acid sequences of> 10-15 nucleotides of the invention contained in the Sequence Listing have utility in conjunction with suitable enzymes and reagents to create copies of H pylori SUBSTITUTE SHEET (RULE 26) WO 96/40893 PCT/US96/09122 -56nucleic acid. More preferably, the sequence will comprise twenty or more nucleotides to convey stability to the hybridization product formed between the primer and the intended target molecules. Binding conditions of primers greater than 100 nucleotides are more difficult to control to obtain specificity. High fidelity PCR can be used to ensure a faithful DNA copy prior to expression. In addition, amplified products can be checked by conventional sequencing methods.
The copies can be used in diagnostic assays to detect specific sequences, including genes from H. pylori and/or other Helicobacter species. The copies can also be incorporated into cloning and expression vectors to generate polypeptides corresponding to the nucleic acid synthesized by PCR, as is described in greater detail herein.
Antisense Nucleic acid or nucleic acid-hybridizing derivatives isolated or synthesized in accordance with the sequences described herein have utility as antisense agents to prevent the expression of H. pylori genes. These sequences also have utility as antisense agents to prevent expression of genes of other Helicobacter species.
In one embodiment, nucleic acid or derivatives corresponding to H. pylori nucleic acids is loaded into a suitable carrier such as a liposome or bacteriophage for introduction into bacterial cells. For example, a nucleic acid having twenty or more nucleotides is capable of binding to bacteria nucleic acid or bacteria messenger RNA. Preferably, the antisense nucleic acid is comprised of 20 or more nucleotides to provide necessary stability of a hybridization product of non-naturally occurring nucleic acid and bacterial nucleic acid and/or bacterial messenger RNA. Nucleic acid having a sequence greater than 1000 nucleotides in length is difficult to synthesize but can be generated by recombinant DNA techniques. Methods for loading antisense nucleic acid in liposomes is known in the art as exemplified by U.S. Patent 4,241,046 issued December 23, 1980 to Papahadjopoulos et al.
II. Expression of H pylori Nucleic Acids Nucleic acid isolated or synthesized in accordance with the sequences described herein have utility to generate polypeptides. The nucleic acid of the invention exemplified in the Sequence Listing or fragments of said nucleic acid encoding active portions of H pylori polypeptides can be cloned into suitable vectors or used to isolate nucleic acid. The isolated nucleic acid is combined with suitable DNA linkers and cloned into a suitable vector.
The function of a specific gene or operon can be ascertained by expression in a bacterial strain under conditions where the activity of the gene product(s) specified by the gene or operon in question can be specifically measured. Alternatively, a gene product may be produced in large quantities in an expressing strain for use as an antigen, an industrial reagent, for structural studies, etc. This expression can be accomplished in a mutant strain which lacks the activity of the gene to be tested, or in a strain that does not produce the SUBSTITUTE SHEET (RULE 26) WO 96/40893 PCT/US96/09122 -57same gene product(s). This includes, but is not limited to other Helicobacter strains, or other bacterial strains such as E. coli, Norcardia, Corynebacterium, Campylobacter, and Streptomyces species. In some cases the expression host will utilize the natural Helicobacter promoter whereas in others, it will be necessary to drive the gene with a promoter sequence derived from the expressing organism an E. coli betagalactosidase promoter for expression in E. coli).
To express a gene product using the natural H. pylori promoter, a procedure such as the following can be used. A restriction fragment containing the gene of interest, together with its associated natural promoter element and regulatory sequences (identified using the DNA sequence data) is cloned into an appropriate recombinant plasmid containing an origin of replication that functions in the host organism and an appropriate selectable marker. This can be accomplished by a number of procedures known to those skilled in the art. It is most preferably done by cutting the plasmid and the fragment to be cloned with the same restriction enzyme to produce compatible ends that can be ligated to join the two pieces together. The recombinant plasmid is introduced into the host organism by, for example, electroporation and cells containing the recombinant plasmid are identified by selection for the marker on the plasmid. Expression of the desired gene product is detected using an assay specific for that gene product.
In the case of a gene that requires a different promoter, the body of the gene (coding sequence) is specifically excised and cloned into an appropriate expression plasmid. This subcloning can be done by several methods, but is most easily accomplished by PCR amplification of a specific fragment and ligation into an expression plasmid after treating the PCR product with a restriction enzyme or exonuclease to create suitable ends for cloning.
A suitable host cell for expression of a gene can be any procaryotic or eucaryotic cell. For example, an H. pylori polypeptide can be expressed in bacterial cells such as E.
coli, insect cells (baculovirus), yeast, or mammalian cells such as Chinese hamster ovary cell (CHO). Other suitable host cells are known to those skilled in the art.
Expression in eucaryotic cells such as mammalian, yeast, or insect cells can lead to partial or complete glycosylation and/or formation of relevant inter- or intra-chain disulfide bonds of a recombinant peptide product. Examples of vectors for expression in yeast S. cerivisae include pYepSecl (Baldari. et al., (1987) Embo J. 6:229-234), pMFa (Kurjan and Herskowitz, (1982) Cell 30:933-943), pJRY88 (Schultz et al., (1987) Gene 54:113- 123), and pYES2 (Invitrogen Corporation, San Diego, CA). Baculovirus vectors available for expression of proteins in cultured insect cells (SF 9 cells) include the pAc series (Smith et al., (1983) Mol. Cell Biol. 3:2156-2165) and the pVL series (Lucklow, and Summers, (1989) Virology 170:31-39). Generally, COS cells (Gluzman, (1981) Cell 23:175-182) are used in conjunction with such vectors as pCDM 8 (Aruffo, A. and Seed, (1987) Proc. Natl. Acad. Sci. USA 84:8573-8577) for transient SUBSTITUTE SHEET (RULE 26) WO 96/40893 PCT/US96/09122 -58amplification/expression in mammalian cells, while CHO (dhfr- Chinese Hamster Ovary) cells are used with vectors such as pMT2PC (Kaufman et al. (1987), EMBOJ. 6:187-195) for stable amplification/expression in mammalian cells. Vector DNA can be introduced into mammalian cells via conventional techniques such as calcium phosphate or calcium chloride co-precipitation, DEAE-dextran-mediated transfection, or electroporation.
Suitable methods for transforming host cells can be found in Sambrook et al. (Molecular Cloning: A Laboratory Manual, 2nd Edition, Cold Spring Harbor Laboratory press (1989)), and other laboratory textbooks.
Expression in procaryotes is most often carried out in E. coli with either fusion or non-fusion inducible expression vectors. Fusion vectors usually add a number of NH 2 terminal amino acids to the expressed target gene. These NH 2 terminal amino acids often are referred to as a reporter group. Such reporter groups usually serve two purposes: 1) to increase the solubility of the target recombinant protein; and 2) to aid in the purification of the target recombinant protein by acting as a ligand in affinity purification. Often, in fusion expression vectors, a proteolytic cleavage site is introduced at the junction of the reporter group and the target recombinant protein to enable separation of the target recombinant protein from the reporter group subsequent to purification of the fusion protein. Such enzymes, and their cognate recognition sequences, include Factor Xa, thrombin and enterokinase. Typical fusion expression vectors include pGEX (Amrad Corp., Melbourne, Australia), pMAL (New England Biolabs, Beverly, MA) and pRIT5 (Pharmacia, Piscataway, NJ) which fuse glutathione S-transferase, maltose E binding protein, or protein A, respectively, to the target recombinant protein. A preferred reporter group is poly(His), which may be fused to the amino or carboxy terminus of the protein and which renders the recombinant fusion protein easily purifiable by metal chelate chromatography.
Inducible non-fusion expression vectors include pTrc (Amann et al., (1988) Gene 69:301-315) and pET 11d (Studier et al., Gene Expression Technology: Methods in Enzvmology 185, Academic Press, San Diego, California (1990) 60-89). While target gene expression relies on host RNA polymerase transcription from the hybrid trp-lac fusion promoter in pTrc, expression of target genes inserted into pET 11d relies on transcription from the T7 gnl 0-lac 0 fusion promoter mediated by coexpressed viral RNA polymerase (T7 gnl). This viral polymerase is supplied by host strains BL21(DE3) or HMS174(DE3) from a resident X prophage harboring a T7 gnl under the transcriptional control of the lacUV 5 promoter.
For example, a host cell transfected with a nucleic acid vector directing expression of a nucleotide sequence encoding an H. pylori polypeptide can be cultured under appropriate conditions to allow expression of the polypeptide to occur. The polypeptide may be secreted and isolated from a mixture of cells and medium containing the peptide.
Alternatively, the polypeptide may be retained cytoplasmically and the cells harvested, lysed and the protein isolated. A cell culture includes host cells, media and other SUBSTITUTE SHEET (RULE 26) WO 96/40893 PCT/US96/09122 -59byproducts. Suitable media for cell culture are well known in the art. Polypeptides of the invention can be isolated from cell culture medium, host cells, or both using techniques known in the art for purifying proteins including ion-exchange chromatography, gel filtration chromatography, ultrafiltration, electrophoresis, and immunoaffinity purification with antibodies specific for such polypeptides. Additionally, in many situations, polypeptides can be produced by chemical cleavage of a native protein tryptic digestion) and the cleavage products can then be purified by standard techniques.
In the case of membrane bound proteins, these can be isolated from a host cell by contacting a membrane-associated protein fraction with a detergent forming a solubilized complex, where the membrane-associated protein is no longer entirely embedded in the membrane fraction and is solubilized at least to an extent which allows it to be chromatographically isolated from the membrane fraction. Several different criteria are used for choosing a detergent suitable for solubilizing these complexes. For example, one property considered is the ability of the detergent to solubilize the H pylori protein within the membrane fraction at minimal denaturation of the membrane-associated protein allowing for the activity or functionality of the membrane-associated protein to return upon reconstitution of the protein. Another property considered when selecting the detergent is the critical micelle concentration (CMC) of the detergent in that the detergent of choice preferably has a high CMC value allowing for ease of removal after reconstitution. A third property considered when selecting a detergent is the hydrophobicity of the detergent.
Typically, membrane-associated proteins are very hydrophobic and therefore detergents which are also hydrophobic, the triton series, would be useful for solubilizing the hydrophobic proteins. Another property important to a detergent can be the capability of the detergent to remove the H. pylori protein with minimal protein-protein interaction facilitating further purification. A fifth property of the detergent which should be considered is the charge of the detergent. For example, if it is desired to use ion exchange resins in the purification process then preferably detergent should be an uncharged detergent. Chromatographic techniques which can be used in the final purification step are known in the art and include hydrophobic interaction, lectin affinity, ion exchange, dye affinity and immunoaffinity.
One strategy to maximize recombinant H pylori peptide expression in E. coli is to express the protein in a host bacteria with an impaired capacity to proteolytically cleave the recombinant protein (Gottesman, Gene Expression Technolovgy: Methods in Enzymology 185, Academic Press, San Diego, California (1990) 119-128). Another strategy would be to alter the nucleic acid encoding an H pylori peptide to be inserted into an expression vector so that the individual codons for each amino acid would be those preferentially utilized in highly expressed E. coli proteins (Wada et al., (1992) Nuc. Acids Res. 20:2111-2118). Such alteration of nucleic acids of the invention can be carried out by standard DNA synthesis techniques.
SUBSTITUTE SHEET (RULE 26) WO 96/40893 PCT/US96/09122 The nucleic acids of the invention can also be chemically synthesized using standard techniques. Various methods of chemically synthesizing polydeoxynucleotides are known, including solid-phase synthesis which, like peptide synthesis, has been fully automated in commercially available DNA synthesizers (See, Itakura et al. U.S. Patent No. 4,598,049; Caruthers et al. U.S. Patent No. 4,458,066; and Itakura U.S. Patent Nos.
4,401,796 and 4,373,071, incorporated by reference herein).
III. H. pylori Polypeptides This invention encompasses isolated H. pylori polypeptides encoded by the disclosed H. pylori genomic sequences, including the polypeptides of the invention contained in the Sequence Listing. Polypeptides of the invention are preferably at least amino acid residues in length. Using the DNA sequence information provided herein, the amino acid sequences of the polypeptides encompassed by the invention can be deduced using methods well-known in the art. It will be understood that the sequence of an entire nucleic acid encoding an H. pylori polypeptide can be isolated and identified based on an ORF that encodes only a fragment of the cognate protein-coding region. This can be acheived, for example, by using the isolated nucleic acid encoding the ORF, or fragments thereof, to prime a polymerase chain reaction with genomic H. pylori DNA as template; this is followed by sequencing the amplified product.
The polypeptides of the invention can be isolated from wild-type or mutant H.
pylori cells or from heterologous organisms or cells (including, but not limited to, bacteria, yeast, insect, plant and mammalian cells) into which an H. pylori nucleic acid has been introduced and expressed. In addition, the polypeptides can be part of recombinant fusion proteins.
H. pylori polypeptides of the invention can be chemically synthesized using commercially automated procedures such as those referenced herein.
Many of the polypeptides of the invention are related to one another. Some of these relationships are described in Table 3 below. Most polypeptides described in Table 3 are over 90% identical to one another as noted in the last two columns; some are between and 90% identical to one another; and very few share between 60% and 70% identity with each other. The polypeptides represented by the sequence identification numbers in the third column of Table 3 result from translations carried out from stop codon to stop codon in the genomic nucleotide sequence of the invention, while those in the first column result from translations carried out from the first methionine or valine codon following the prior stop codon and proceeding to the final stop codon in the nucleotide sequence. In some cases, the nucleotide sequence encoding the related polypeptides is slightly different, resulting in some differences in amino acid residues of the related polypeptides. In many cases, the related polypeptides differ significantly in length, with one polypeptide containing amino acid residues in addition to those in common between the two SUBSTITUTE SHEET (RULE 26) WO 96/40893 PCT/US96/09122 -61polypeptides. In all cases, the relationships described in Table 3 are highly significant, and the nucleotide sequences encoding these related polypeptides are also very similar to one another. For example, the nucleotide probes derived from the coding sequence of the polypeptides in column one can be used in PCR or hybridization experiments to identify clones carrying the nucleotide sequence encoding the polypeptides of column three.
The relationships between the polypeptides shown in Table 3 can be classified in five broad categories as follows. First, for many polypeptides (designated in the last column of the Table the polypeptide denoted in column one is identical to the polypeptide denoted in column three except for an occasional addition of a few putative amino acid residues at the N-terminus which result from the fact that the polypeptides of column three were derived by translating from stop codon to stop codon instead of from a predicted start codon Met or Val) to a stop codon as was done for the polypeptides in column one.
Second, for most polypeptides (designated in the last column of the Table 3), the polypeptide of column one is at least 95% identical to the polypeptide of column three except that the polypeptide in column three is longer (at either or both ends) by one or more amino acid residues which do not result from the difference between reading from stop to stop instead of from start to stop.
Third, for some polypeptides (designated in the last column of Table the converse is true, the polypeptide of column one is at least 95% identical to the polypeptide of column three except that the polypeptide in column three is shorter (at either or both ends).
Fourth, for some polypeptides (designated in the last column of Table the polypeptide of column one shares a high level of amino acid identity at least with the polypeptide of column three in the region in which they overlap, but shares little or no identity less than 95%) at one or both ends. The level of identity of the polypeptides in columns one and three in categories and is highly significant.
For example, a typical H. pylori gene product will exhibit amino acid sequence identities of between 92% to 100% among strains of H. pylori isolated from human patients (see Table 10 below).
Finally, a fifth class of polypeptides in column one (designated in the last column of Table 3) are closely related but differ significantly less than 95% identical) from the polypeptide of column three. These polypeptides are likely "paralogs," members of related gene families in H. pylori.
SUBSTITUTE SHEET (RULE 26) WO 96/40893 PCT/US96/09122 -62- TABLE3 Length Length Identity: SeqID (aa) SeqID (aa) Overlap Length Category 384 509 1779 593 100.0:504aa B 386 133 1713 205 99.2:127aa B 387 158 1743 340 98.7:155 aa B 388 112 1489 330 100.0:105aa B 389 650 1643 369 95.4:65aa D 390 62 1598 327 90.2:61aa E 391 619 1747 991 99.3:608aa B 392 110 1570 183 93.1:101 aa E 393 68 1811 85 97.1:68aa B 394 446 1884 594 99.5:433aa B 395 84 1503 347 100.0:84aa B 396 40 1504 519 88.2:34aa E 397 300 1531 273 98.9:267aa C 398 214 1795 197 99.0:192aa C 399 137 1639 199 96.4:137aa B 400 272 1725 285 99.3:271aa B 401 287 1470 455 98.9:277aa D 402 106 1596 302 99.1 :106 aa B 403 157 1654 197 99.3:150aa B 404 278 1552 362 100.0:277aa B 405 120 1858 529 100.0:116aa B 406 226 1562 297 100.0:216aa B 407 62 1752 157 77.6:58aa E 408 50 1663 74 97.9:47aa B 410 188 1803 351 87.1 :155aa E 411 130 1685 497 100.0:129aa B 412 183 1843 185 100.0:183 aa A 413 194 1874 508 97.6:169aa D 414 235 1518 246 100.0:235aa B 415 88 1538 676 97.5:80aa B 416 109 1871 335 99.1:109aa B 417 107 1782 593 94.4:90 aa E 418 136 1544 441 100.0:135aa B 419 54 1513 175 97.0:33aa E 420 125 1642 539 96.7:122 aa B 421 249 1738 346 99.6:249aa B 422 86 1715 128 97.5:79aa B 423 128 1534 149 100.0:128aa B 424 93 1875 178 100.0:93aa B 425 88 1804 105 97.7:88aa B 426 128 1524 116 62.4:117aa E 427 108 1762 109 100.0:108aa A 428 118 1539 276 100.0:118aa B 429 54 1754 113 89.6:48aa E 430 288 1483 377 95.5 :286 aa B 431 303 1785 248 98.2:170aa D 431 303 1784 148 96.4:138aa D 432 192 1478 408 99.5:192aa B 433 168 1517 426 99.3:151aoa D SUBSTITUTE SHEET (RULE 26) WO 96/40893 WO 9640893PCTIUS96/09 122 -63- 434 153 1679 403 100.0:153 aaB 435 162 1806 173 98.1 :161 aaB 436 59 1834 80 37.5 24 aaE 437 222 1533 288 100.0 221 aaB 438 53 1737 260 93.5 31 aaE 439 109 1683 121 100.0 109 aaB 440 73 1773 280 100.0:73 aaB 441 237 1685 497 96.0 :198 aa D 442 92 1521 646 100.0:84 aa D 443 97 1774 327 100.0 96 aa B 444 280 1556 284 100.0 280 aa A 445 187 1604 253 95.5 155 aa D 446 58 1510 198 96.4 :55aa B 447 85 1496 155 100.0 85 aa B 448 90 1724 90 100.0 90Oaa A 449 105 1788 141 98.0 100 aa D 450 172 1495 239 100.0 172 aa B 451 212 1456 139 81.7 126 aa E 452 182 1702 192 97.0:166 aa D 453 224 1658 228 100.0 224 aa A 454 131 1895 159 100.0:131 aa B 455 73 1787 370 100.0 :54 aa D 456 92 1587 295 96.6 87 aa B 457 205 1735 310 100.0:195 aa B 458 41 1479 144 97.6 41laa B 459 219 1584 297 100.0 219 aa B 460 188 1546 375 89.3 187 aa E 461 231 1780 438 97.3:225 aa B 462 63 1645 71 100.0 :63 aa B 463 183 1664 242 97.8 182 aa B 464 117 1586 234 99.1:113 aa B 465 153 1773 280 98.0 153 aa B 466 43 1610 308 100.0 :43 aa B 467 240 1636 255 97.0 :237 aa B 468 209 1868 240 96.6: 206 aa B 469 95 1628 321 98.5:65 aa D 470 229 1595 375 96.5 :228 aa B 471 92 1713 205 90.1 :71 aa E 472 96 1492 352 95.4 87 aa B 473 1178 1748 1183 100.0 1178 aa A 474 163 1822 113 92.7:109 aa E 474 163 1820 88 93.1 5S8 aa E 475 466 1840 467 100.0:466 aa A 476 60 1500 90 97.0 :33 aa D 477 249 1854 254 100.0 248 aa B 478 44 1772 528 100.0 44 aa B 479 421 1693 421 99.8 421 aa A 480 167 1555 340 98.1: 162 aa B 481 89 1888 236 100.0 :89 aa B 482 237 1873 461 97.5 236 aa B 483 471 1594 428 99.3:301laa C 484 123 1655 366 87.9:107 aa E 485 127 1655 366 99.2:127 aa B 486 259 1517 259 100.0 259 aa A 487 17 1481 101 93.3 :15 aa E 488 77 1704 246 100.0 77 aa B SUBSTITUTE SHEET (RULE 26) WO 96/40893 WO 9640893PCTIUS96/09122 -64- 489 180 1554 180 100.0:180Oaa A 490 213 1638 577 92.3 209 aa E 491 148 1452 157 100.0:148 aa B 492 281 1519 849 99.6 281 aa B 493 144 1525 377 94.9 118 aa D 494 73 1539 276 95.8:71laa B 495 311 1670 446 99.0 :311laa B 496 115 1842 384 99.1:114 aa B 497 200 1600 459 100.0 200 aa B 498 264 1828 458 100.0:264 aa B 499 339 1490 362 99.7 339 aa B 500 146 1449 430 94.4: 142 aa E 501 60 1465 240 98.3 :58 aa B 502 351 1458 532 98.6 :346 aa B 503 233 1666 296 9 4.3 :230 aa E 504 32 1513 175 100.0 :32 aa B 505 171 1462 452 91.8 :171 aa B 506 33 1672 121 100.0 24 aa D 507 100 1650 192 80.0 90Oaa E 508 79 1772 528 80.8 78 aa E 509 70 1662 88 96.2 :53 aa D 510 130 1530 131 100.0 130Oaa A 511 53 1723 163 91.8 49 aa E 512 79 1572 189 98.5 65 aa D 513 102 1889 114 99.0:l100aa B 514 15 1516 407 100.0:l12 aaB 515 378 1747 991 97.9 3 77 aa B 516 1027 1692 2440 100.0 1027 aa B 517 155 1831 182 89.6 154 aa E 518 62 1552 362 74.5 47 aa E 519 237 1557 241 100.0 237 aa A 520 83 1627 424 100.0 83 aa B 522 64 1680 227 98.4: 63 aa B 523 228 1532 241 100.0 :228 aa B 524 273 1710 189 97.2:l180Oaa C 524 273 1712 115 100.0 99 aa C 525 15 1612 65 100.0 15 aa B 526 115 1733 112 94.6:l111aa C 527 67 1755 156 100.0 :62 aaD 528 323 1635 336 100.0 :322 aa B 529 10 1731 101 50.0 10 aa B 530 12 1455 284 100.0:12 aa B 531 79 1528 101 94.9 79 aa B 532 95 1887 279 100.0 95 aa B 533 154 1591 168 100.0 152 aa B 534 68 1501 283 100.0 67 aa B 535 313 1519 849 95.5 313 aa B 536 319 1486 325 100.0 319 aa A 537 118 1707 154 90.9:l110aa E 538 89 1674 161 88.2 76 aa E 539 92 1838 100 100.0 92 aaA 540 138 1525 377 86.9 137 aaB 541 277 1661 394 96.0 273 aaD 542 254 1567 392 98.0 254 aaB 543 185 1467 594 99.5:185 aaB 544 37 1886 326 100.0 :37,aaB SUBSTITUTE SHEET (RULE 26) WO 96/40893 WO 9640893PCTIUS96/09122 545 94 1772 528 89.1 :92 aaE 546 182 1760 366 100.0:182 aaB 547 247 1776 150 100.0 146 aa 547 247 1775 88 100.0 87 aa 548 422 1798 426 100.0: 422 aaA 549 61 1620 78 96.7:60 aaB 550 54 1566 309 37.8 45 aaE 551 298 1751 518 98.0 :297 aa B 552 91 1738 346 95.5 :88 aa D 553 ill 1764 130 100.0:Illlaa B 554 137 1626 93 100.0 :84 aa D 555 124 1717 114 89.2:l111aa E 556 86 1597 432 89.7 78 aa E 557 87 1457 97 100.0 86 aa B 558 108 1750 154 99.1 10 lOaa B 559 142 1619 211 97.9:141 aa B 560 231 1580 315 99.6 231 aa B 561 186 1446 275 88.3 180 aa E 562 183 1515 198 100.0:183 aa B 563 154 1477 188 100.0 154 aa B 564 288 1 767 303 100.0:288 aa B 565 420 1841 424 100.0:420 aa A 566 72 1450 486 98.5:67 aaD 567 205 1799 270 99.5 199 aa D 568 328 1893 338 100.0 328 aa B 569 140 1855 614 84.8:125 aa E 570 76 1499 184 98.1 :53 aa D 571 194 1660 201 100.0:193 aa B 572 140 1583 163 96.9 130Oaa D 573 308 1676 316 100.0 308 aa B 574 339 1667 468 99.1 335 aa B 575 207 1688 208 98.1 207 aa A 576 251 1891 267 100.0 251 aa B 577 69 1745 109 96.7 61laa D 578 112 1519 849 99.1 112 aa B 579 152 1649 543 98.7 152 aa B 580 130 1853 220 98.3 120Oaa D 581 113 1614 134 100.0 113 aa B 582 174 1569 209 100.0 174 aa B 583 35 1752 157 34.4 32 aa E 584 308 1728 316 100.0 307 aa B 585 702 1857 797 99.9: 702 aa B 586 293 1633 664 96.2 :293 aa B 587 52 1542 429 100.0 52 aa B 588 182 1504 519 100.0 182 aa B 589 251 1622 262 99.6 251 aa B 590 40 1632 61 97.5 40Oaa B 591 122 1691 717 99.1 113 aa D 592 113 1768 121 100.0 113 aa B 593 437 1520 448 100.0 437 aa A 594 146 1549 200 93.2 146 aa E 595 128 1494 131 99.2 127 aa B 596 95 1667 468 100.0 93 aa B 597 102 1447 149 100.0 91laa D 598 127 1879 138 100.0 127 aa B 599 502 1881 928 99.2 500 aa B SUBSTITUTE SHEET (RULE 26) WO 96/40893 WO 9640893PCT/US96/09122 -66- 600 42 1625 91 100.0 :42 aaB 601 341 1454 381 99.7 341 aaB 602 465 1694 442 9 8.2 433 aaD 602 465 1896 259 9 9 .6:238 aaD 603 193 1484 229 9 9 .4 170Oaa 604 141 1673 130 97.6 126 aaD 605 159 1582 358 83.3: 156 aaE 606 376 1565 382 100.0: 376 aa B 607 352 1862 363 99.1 :352 aa B 608 88 1807 144 98.7 77 aa D 609 86 1553 181 72.0:82 aa E 610 76 1527 77 100.0 76 aa A 612 162 1525 377 91.3:161 aaE 614 66 1470 455 8. 1a 615 117 1844 982 95.5 111laaD 616 83 1723 163 9. 2a 617 77 1763 275 8. 7a 618 176 1696 149 93.6:125 aaE 618 176 1698 231 92.3 65 aa E 619 144 1498 577 96.0:124 aa D 620 90 1516 407 98.9 90Oaa B 621 268 1571 275 100.0 268 aa B 622 171 1753 206 99.4:171 aa B 623 102 1559 256 100.0 :84 aa D 624 117 1819 640 94.2 104 aa E 625 237 1758 842 99.6 233 aa B 626 199 1464 200 100.0 198 aa C 627 225 1611 347 97.7 221 aa B 627 225 1608 97 97.8 91laa C 628 86 1772 528 90.4 83 aa E 629 496 1558 539 100.0 496 aa B 630 142 1778 332 99.1 11 llaa D 631 153 1709 111 76.9 108 aa E 631 153 1708 76 60.9: 46 aa E 633 93 1848 106 100.0 :93 aa B 634 177 1603 531 98.9 :175 aa B 635 88 1812 93 100.0 88 aa A 636 115 1746 122 100.0 115 aa B 637 261 1850 304 98.5 260 aa B 638 191 1691 717 99.5 185 aa B 639 351 1697 373 99.7 :351 aa B 640 351 1601 355 100.0 :342 aa D 641 146 1592 320 96.6:145 aa B 642 190 1796 376 100.0 190Oaa B 643 489 1705 957 99.4 468 aa D 644 249 1706 249 100.0 248 aa A 645 120 1540 269 100.0 104 aa D 646 109 1550 350 100.0 108 aa B 648 158 1573 237 95.5 155 aa D 649 312 1721 312 100.0 :312 aa A 650 56 1839 242 98.1 52 aa D 651 199 1813 261 9 9.5 196 aa B 652 82 1756 99 96.3 81laa D 1653 89 1475 227 100.0 69 aaB SUBSTITUTE SHEET (RULE 26) WO 96/40893 WO 9640893PCTIUS96/09122 -67- 654 111 1535 119 9 8.2 111laaB 655 65 1686 276 98.3 59 aaD 656 268 1892 272 100.0 268 aaA 657 100 1597 432 100.0:84 aaD 658 80 1640 276 97.2 72 aa 659 205 1824 217 100.0 205 aaB 660 124 1471 67 98.4:64 aaD 660 124 1472 186 96.7 60 aaD 661 93 1618 95 98.9 93 aaB 662 80 1568 170 98.7 79 aaB 663 214 1749 224 100.0 214 aaB 664 78 1668 214 97.3 75 aaD 665 177 1844 982 78.6:173 aaE 666 258 1578 275 94.1 :254 aa E 667 75 1742 360 100.0 :75 aa B 668 421 1699 421 99.5 421 aa A 669 81 1542 429 100.0 81aa B 670 112 1540 269 76.1 113 aa E 671 326 1689 246 92.8 208 aa E 672 272 1727 279 100.0 271 aa A 673 78 1661 394 100.0 78 aa B 674 400 1736 419 100.0:400 aa B 675 91 1522 273 95.5 88 aa D 676 126 1561 131 100.0 126 aa A 677 195 1577 301 76.5 196 aa E 678 72 1814 90 98.6 72 aa B 679 111 1572 189 100.0:l111aa B 680 142 1847 207 92.6:135 aa E 681 63 1516 407 96.4 56 aa D 682 310 1700 446 99.3 :301 aaB 683 169 1744 219 100.0:169 aa B 684 85 1611 347 88.1 84 aa E 685 77 1829 251 97.3 75 aa D 686 197 1634 425 99.0 194 aa D 687 142 1722 197 100.0 136 aa D 688 86 1805 87 100.0 86 aa A 689 121 1759 356 97.5 118 aa B 690 59 1789 77 84.6 52 aa E 691 142 1675 420 97.1 :140 aa B 692 80 1722 197 83.3 60Oaa E 693 180 1659 187 100.0:179 aa B 694 75 1529 159 100.0 75 aa B 695 99 1849 119 100.0 99 aa B 696 209 1701 430 99.5 :205 aa B 697 75 1616 196 100.0 75 aa B 698 121 1678 460 100.0:121 aa B 699 102 1579 139 99.0 100 aa B 700 131 1595 375 99.2:131 aa B 701 441 1488 444 96.9 426 aa D 702 127 1774 327 99.1 11 llaa D 703 287 1765 327 93.9 279 aa E 704 46 1581 111 95.2 21laa D 705 115 1647 117 100.0 115 aa A 706 86 1463 111 100.0 86 aa B 707 44 1588 68 100.0 44 aa B 1708 560 1589 1413 98.8: 560Oaa B SUBSTITUTE SHEET (RULE 26) WO 96/40893 PCTIUS96/09 122 -68- 709 125 1607 443 95.8 :118 aaD 710 96 1469 540 100.0: 73 aaD 711 81 1629 244 96.3 712 141 1671 375 100.0:125 aaD 713 51 1867 193 96.1 :51 aa 714 233 1833 240 99.5:218 aaD 715 266 1644 271 100.0:265 aaB 716 158 1883 226 94.7:150 aa E 717 191 1860 240 100.0 189 aa B 718 243 1817 256 99.6 243 aaB 719 236 1617 667 98.3 236 aa B 720 175 1523 592 97.1 :172 aa B 721 226 1770 340 92.7 218 aa E 722 79 1629 244 100.0: 74 aa D 723 65 1506 229 100.0 :49 aa D 724 138 1675 426 93.2:132 aa E 725 210 1832 215 100.0:210 aa A 726 296 1821 223 100.0 190Oaa D 726 296 1819 640 99.1 10 lOaa D 727 94 1706 249 97.8 :91 aa D 728 83 1593 171 100.0: 83 aa B 729 203 1448 268 100.0:202 aa B 730 220 1656 242 100.0 220 aa B 731 116 1818 196 100.0 115 aa B 732 248 1474 248 100.0:248 aa A 733 150 1459 347 100.0:118 aa D 734 228 1545 302 96.9 :227 aa B 735 187 1597 432 100.0 172 aa D 736 198 1761 354 100.0:198 aaB 737 208 1780 438 93.8 :208 aa E 738 201 1842 384 100.0 193 aa D 739 127 1669 405 21.6 74 aa E 740 79 1615 280 97.3 75 aa D 741 49 1878 443 91.3:46 aa E 742 412 1877 425 97.8 412 aa B 743 89 1482 111 100.0 :89 aa B 744 192 1502 222 98.4:189 aa B 745 109 1797 304 96.3 109 aa B 746 116 1791 359 94.8:116 aa B 747 163 1711 321 100.0:163 aa B 748 40 1483 377 100.0:40Oaa B 749 45 1770 340 95.2 42 aa D 750 118 1867 193 92.2 116 aa E 751 200 1491 211 100.0 200 aa B 752 79 1890 80 100.0 79 aa A 753 98 1837 268 98.7 79 aa D 754 146 1653 413 100.0:141 aa B 755 206 1638 577 93.7:206 aa B 756 97 1526 89 100.0:66 aa D 757 197 1794 198 100.0 197 aa A 758 149 1872 94 97.5:80Oaa D 759 68 1882 291 100.0 68 aa B 760 135 1631 162 99.3 :134 aa B 761 93 1884 594 100.0:69 aa D 1762 73 1883 226 100.0 73 aa B 1763 268 1859 430 95.4 263 aa B SUBSTITUTE SHEET (RULE 26) WO 96/40893 WO 9640893PCTIUS96/09122 -69- 764 274 1537 277 100.0 273 aa B 765 134 1714 136 99.2:133 aaA 766 72 1810 74 9. 1a 767 147 1802 285 100.0 147 aa B 768 144 1541 241 100.0 144 aa B 769 47 1684 75 1 00.0 47 aaB 770 129 1505 183 9 0 2 122 aaE 771 242 1536 235 9 9 .1 232 aa 773 143 1826 259 96.5 :143 aaB 774 218 1777 383 9 9 .5 217 aaB 775 84 1637 143 100.0 84 aaB 776 76 1774 327 9. 3a 777 155 1585 263 79.7:133 aa E 778 192 1480 299 91.5 189 aa E 779 171 1551 186 99.4: 171 aa B 780 141 1760 366 9 9.2 :129 aa D 781 70 1741 95 100.0 :70Oaa
B
782 153 1687 223 9 8 .0 153 aa B 783 183 1869 184 100.0 183 aa A 784 67 1846 231 100.0: 67 aa B 785 254 1730 256 100.0 253 aa B 786 173 1466 251 100.0 166 aa D 787 259 1808 322 100.0 238 aa D 788 294 1786 131 9 3 .7 126 aa E 788 294 1630 163 9 4 .0 116 aa E 789 194 1655 366 9 9 .2 122 aa D 789 194 1646 75 100.0 72 aa C 790 132 1790 273 100.0 132 aa B 791 213 1575 216 98.1 :213 aa A 792 47 1605 86 100.0 :47 aa B 793 143 1864 342 93.0 :143 aa E 794 69 1766 93 100.0 :69 aa B 795 144 1504 519 9 5.
7 138 aa D 796 190 1590 193 100.0 190Oaa
A
797 84 1792 215 8 3 .5 79 aa E 798 135 1613 138 100.0:135 aa A 799 255 1885 424 99.6 :253 aa B 800 243 1493 205 87.1 14 l4aa
B
800 243 1497 131 100.0 126 aa C 801 252 1563 255 100.0 252 aa A 802 165 1720 91 100.0 88 aa C 802 165 1718 99 9 2 .7 82 aa E 803 171 1602 297 8 5.5 159 aa E 804 62 1485 165 100.0 61laa B 805 199 1514 219 100.0 199 aa B 806 131 1880 391 8 6 .2 30Oaa E 807 101 1719 257 95.0 100 aa B 808 80 1585 263 98.8 80Oaa B 809 447 1781 344 99.7 :331 aa D 809 447 1783 118 98.3 117 aa C 810 218 1564 250 100.0 218 aa B 811 192 1478 408 99.5 192 aa B 812 341 1729 354 100.0 :340 aa B 813 201 1523 592 100.0 158 aa D 1814 130 1769 306 92.3 130.Oaa
B
SUBSTITUTE SHEET (RULE 26) WO 96/40893 PCT/US96/09122 815 144 1835 548 78.4 116aa E 815 144 1815 377 84.3 :121 aa E 816 309 1894 310 100.0"309aa
A
817 164 1823 156 96.7:153 aa D 818 54 1703 87 100.0:53aa
B
819 202 1716 215 9 9 .5 202aa B 820 169 1870 115 100.0 ll0aa D 821 186 1451 254 100.0"186aa
B
822 72 1609 180 96 .6:58aa
D
823 122 1633 664 9 4 .9"118aa
D
824 13 1695 70 100.0 "13aa B 824 13 1567 392 100.0"13aa
B
825 99 1771 144 100.0"86aa
D
826 71 1512 154 98.6-71aa
B
827 150 1456 139 9 3 .7"127aa
E
828 255 1651 155 100.0-155aa
C
828 255 1648 109 9 8 .0 "102aa D 829 106 1726 147 99.1 106 aa B 830 527 1509 567 9 9 .8 524aa B 831 124 1740 214 9 9 .2"123aa
B
832 110 1690 400 9 8 2 "110aa
B
833 326 1856 325 100.0:325aa
C
834 253 1543 191 9 6 7 184aa D 835 597 1876 638 100.0 594aa B 836 156 1621 345 99.4"154aa
B
837 157 1624 253 97.4 155 aa B 838 191 1465 241 9 6.8"190aa
B
839 90 1548 231 92.9:85aa
E
840 277 1682 298 99.6 "277 aa B 841 58 1508 270 98.1 "54aa
D
842 139 1734 139 88.4:129 aa E 843 279 1476 276 100.0 269aa C 844 36 1852 83 94.4 :36aa
B
845 129 1460 196 100.0"129aa
B
846 127 1473 172 100.0 105 aa D 847 276 1657 319 100.0 276aa B 848 126 1801 187 9 8 4 "126aa
B
849 242 1669 405 9 7 .0 2 36aa D 850 151 1816 217 100.0 151 aa B 851 154 1641 194 100.0"154aa
B
852 496 1665 327 9 7 .5 3 14aa C 853 179 1606 272 9 7 2 1 7 9aa B 855 160 1487 198 9 6 9 "160aa B 856 94 1836 420 100.0:93aa
B
857 146 1845 371 99.3 "146aa
B
858 205 1507 366 98.5 202aa
B
859 173 1827 198 100.0 149aa
D
860 193 1681 294 100.0 "175aa D 861 104 1865 253 100.0 "104aa B 862 355 1599 358 100.0 355aa B 863 93 1825 236 97.8 92aa B 864 82 1677 315 97.5"81aa
B
865 234 1861 249 9 9.1 233aa
B
866 239 1652 405 99.2 238aa
B
867 86 1468 201 77.4-84aa
E
868 289 1574 395 94.4 284aa
E
SUBSTITUTE SHEET (RULE 26) WO 96/40893 PCT/US96/09122 -71- 869 436 1863 662 100.0 :436 aa B 870 114 1560 121 100.0 114 aa B 871 173 1757 362 98.8 173 aa B 872 116 1866 145 98.1 105 aa D 873 127 1797 304 63.9 :83 aa E 873 127 1799 270 89.7 :58 aa E 873 127 1800 62 97.4 :38 aa D 873 127 1801 187 82.0 50 aa E 874 150 1461 179 100.0 150 aa B 875 209 1511 339 98.9: 188 aa D 876 234 1739 615 99.6 230 aa B 877 395 1830 879 99.7 :379 aa D 878 103 1623 413 97.0 :99 aa D 879 265 1809 566 89.8 265 aa B 880 364 1576 442 98.6 346 aa D IV. Identification of Nucleic Acids Encoding Vaccine Components and Targets for Agents Effective Against H. pvylori The disclosed H. pylori genome sequence includes segments that direct the synthesis of ribonucleic acids and polypeptides, as well as origins of replication, promoters, other types of regulatory sequences, and intergenic nucleic acids. The invention encompasses nucleic acids encoding immunogenic components of vaccines and targets for agents effective against H. pylori. Identification of said immunogenic components involved in the determination of the function of the disclosed sequences, which can be achieved using a variety of approaches. Non-limiting examples of these approaches are described briefly below.
Homology to known sequences: Computer-assisted comparison of the disclosed H.
pylori sequences with previously reported sequences present in publicly available databases is useful for identifying functional H. pylori nucleic acid and polypeptide sequences. It will be understood that protein-coding sequences, for example, may be compared as a whole, and that a high degree of sequence homology between two proteins (such as, for example, >80-90%) at the amino acid level indicates that the two proteins also possess some degree of functional homology, such as, for example, among enzymes involved in metabolism, DNA synthesis, or cell wall synthesis, and proteins involved in transport, cell division, etc.
In addition, many structural features of particular protein classes have been identified and correlate with specific consensus sequences, such as, for example, binding domains for nucleotides, DNA, metal ions, and other small molecules; sites for covalent modifications such as phosphorylation, acylation, and the like; sites of protein:protein interactions, etc.
These consensus sequences may be quite short and thus may represent only a fraction of the entire protein-coding sequence. Identification of such a feature in an H. pylori sequence is therefore useful in determining the function of the encoded protein and identifying useful targets of antibacterial drugs.
Of particular relevance to the present invention are structural features that are common to secretory, transmembrane, and surface proteins, including secretion signal SUBSTITUTE SHEET (RULE 26) WO 96/40893 PCT/US96/09122 -72peptides and hydrophobic transmembrane domains. H. pylori proteins identified as containing putative signal sequences and/or transmembrane domains are useful as immunogenic components of vaccines.
Identification of essential genes: Nucleic acids that encode proteins essential for growth or viability of H pylori are preferred drug targets. H pylori genes can be tested for their biological relevance to the organism by examining the effect of deleting and/or disrupting the genes, by so-called gene "knockout", using techniques known to those skilled in the relevant art. In this manner, essential genes may be identified.
Strain-specific sequences: Because of the evolutionary relationship between different H pylori strains, it is believed that the presently disclosed H pylori sequences are useful for identifying, and/or discriminating between, previously known and new H pylori strains. It is believed that other H pylori strains will exhibit at least 70% sequence homology with the presently disclosed sequence. Systematic and routine analyses of DNA sequences derived from samples containing H pylori strains, and comparison with the present sequence allows for the identification of sequences that can be used to discriminate between strains, as well as those that are common to all H. pylori strains. In one embodiment, the invention provides nucleic acids, including probes, and peptide and polypeptide sequences that discriminate between different strains of H pylori. Strainspecific components can also be identified functionally by their ability to elicit or react with antibodies that selectively recognize one or more H pylori strains.
In another embodiment, the invention provides nucleic acids, including probes, and peptide and polypeptide sequences that are common to all H pylori strains but are not found in other bacterial species.
Specific Example: Determination Of Candidate Protein Antigens For Antibody And Vaccine Development The selection of candidate protein antigens for vaccine development can be derived from the nucleic acids encoding H. pylori polypeptides. First, the ORF's can be analyzed for homology to other known exported or membrane proteins and analyzed using the discriminant analysis described by Klein, et al. (Klein, Kanehsia, and DeLisi, C.
(1985) Biochimica et Biophysica Acta 815, 468-476) for predicting exported and membrane proteins.
Homology searches can be performed using the BLAST algorithm contained in the Wisconsin Sequence Analysis Package (Genetics Computer Group, University Research Park, 575 Science Drive, Madison, WI 53711) to compare each predicted ORF amino acid sequence with all sequences found in the current GenBank, SWISS-PROT and PIR databases. BLAST searches for local alignments between the ORF and the databank sequences and reports a probability score which indicates the probability of finding this sequence by chance in the database. ORF's with significant homology probabilities SUBSTITUTE SHEET (RULE 26) WO 96/40893 PCT/IUS96/09122 -73lower than lx10 6 that the homology is only due to random chance) to membrane or exported proteins represent protein antigens for vaccine development. Possible functions can be provided to H. pylori genes based on sequence homology to genes cloned in other organisms.
Discriminant analysis (Klein, et al. supra) can be used to examine the ORF amino acid sequences. This algorithm uses the intrinsic information contained in the ORF amino acid sequence and compares it to information derived from the properties of known membrane and exported proteins. This comparison predicts which proteins will be exported, membrane associated or cytoplasmic. ORF amino acid sequences identified as exported or membrane associated by this algorithm are likely protein antigens for vaccine development.
Infrequently it is not possible to distinguish between multiple possible nucleotides at a given position in the nucleic acid sequence. In those cases the ambiguities are denoted by an extended alphabet as follows: These are the official IUPAC-IUB single-letter base codes Code
G
A
T
C
R
Y
M
K
S
W
H
B
V
D
N
Base Description Guanine Adenine Thymine Cytosine Purine Pyrimidine Amino Ketone Strong interaction Weak interaction Not-G Not-A Not-T (not-U) Not-C Any (A or G) (C or T or U) (A or C) (G or T) (C or G) (A or T) (A or C or T) (C or G or T) (A or C or G) (A or G or T) (A or C or G or T) The amino acid translations of this invention account for the ambiguity in the nucleic acid sequence by translating the ambiguous codon as the letter In all cases, the permissible amino acid residues at a position are clear from an examination of the nucleic acid sequence based on the standard genetic code.
SUBSTITUTE SHEET (RULE 26) WO 96/40893 PCT/US96/09122 -74- V. Production of Fragments and Analogs of H. pvylori Nucleic Acids and Polypeptides Based on the discovery of the H. pylori gene products of the invention provided in the Sequence Lsiting, one skilled in the art can alter the disclosed structure (of H pylori genes), by producing fragments or analogs, and test the newly produced structures for activity. Examples of techniques known to those skilled in the relevant art which allow the production and testing of fragments and analogs are discussed below. These, or analogous methods can be used to make and screen libraries of polypeptides, libraries of random peptides or libraries of fragments or analogs of cellular proteins for the ability to bind H.
pylori polypeptides. Such screens are useful for the identification of inhibitors of H. pylori.
Generation of Fragments Fragments of a protein can be produced in several ways, recombinantly, by proteolytic digestion, or by chemical synthesis. Internal or terminal fragments of a polypeptide can be generated by removing one or more nucleotides from one end (for a terminal fragment) or both ends (for an internal fragment) of a nucleic acid which encodes the polypeptide. Expression of the mutagenized DNA produces polypeptide fragments.
Digestion with "end-nibbling" endonucleases can thus generate DNA's which encode an array of fragments. DNA's which encode fragments of a protein can also be generated by random shearing, restriction digestion or a combination of the above-discussed methods.
Fragments can also be chemically synthesized using techniques known in the art such as conventional Merrifield solid phase f-Moc or t-Boc chemistry. For example, peptides of the present invention may be arbitrarily divided into fragments of desired length with no overlap of the fragments, or divided into overlapping fragments of a desired length.
Alteration of Nucleic Acids and Polvpeptides: Random Methods Amino acid sequence variants of a protein can be prepared by random mutagenesis of DNA which encodes a protein or a particular domain or region of a protein. Useful methods include PCR mutagenesis and saturation mutagenesis. A library of random amino acid sequence variants can also be generated by the synthesis of a set of degenerate oligonucleotide sequences. (Methods for screening proteins in a library of variants are elsewhere herein).
PCR Mutagenesis In PCR mutagenesis, reduced Taq polymerase fidelity is used to introduce random mutations into a cloned fragment of DNA (Leung et al., 1989, Technique 1:11-15). The DNA region to be mutagenized is amplified using the polymerase chain reaction (PCR) under conditions that reduce the fidelity of DNA synthesis by Taq DNA polymerase, e.g., by using a dGTP/dATP ratio of five and adding Mn 2 to the PCR reaction. The pool of amplified DNA fragments are inserted into appropriate cloning vectors to provide random mutant libraries.
SUBSTITUTE SHEET (RULE 26) WO 96/40893 PCT/US96/09122 Saturation Mutagenesis Saturation mutagenesis allows for the rapid introduction of a large number of single base substitutions into cloned DNA fragments (Mayers et al., 1985, Science 229:242). This technique includes generation of mutations, by chemical treatment or irradiation of single-stranded DNA in vitro, and synthesis of a complimentary DNA strand. The mutation frequency can be modulated by modulating the severity of the treatment, and essentially all possible base substitutions can be obtained. Because this procedure does not involve a genetic selection for mutant fragments both neutral substitutions, as well as those that alter function, are obtained. The distribution of point mutations is not biased toward conserved sequence elements.
Degenerate Oligonucleotides A library of homologs can also be generated from a set of degenerate oligonucleotide sequences. Chemical synthesis of a degenerate sequences can be carried out in an automatic DNA synthesizer, and the synthetic genes then ligated into an appropriate expression vector. The synthesis of degenerate oligonucleotides is known in the art (see for example, Narang, SA (1983) Tetrahedron 39:3; Itakura et al. (1981) Recombinant DNA, Proc 3rd Cleveland Sympos. Macromolecules, ed. AG Walton, Amsterdam: Elsevier pp273-289; Itakura et al. (1984) Annu. Rev. Biochem. 53:323; Itakura et al. (1984) Science 198:1056; Ike et al. (1983) Nucleic Acid Res. 11:477. Such techniques have been employed in the directed evolution of other proteins (see, for example, Scott et al. (1990) Science 249:386-390; Roberts et al. (1992) PNAS 89:2429-2433; Devlin et al.
(1990) Science 249: 404-406; Cwirla et al. (1990) PNAS 87: 6378-6382; as well as U.S.
Patents Nos. 5,223,409, 5,198,346, and 5,096,815).
Alteration of Nucleic Acids and Polvpeptides: Methods for Directed Mutagenesis Non-random or directed, mutagenesis techniques can be used to provide specific sequences or mutations in specific regions. These techniques can be used to create variants which include, deletions, insertions, or substitutions, of residues of the known amino acid sequence of a protein. The sites for mutation can be modified individually or in series, by substituting first with conserved amino acids and then with more radical choices depending upon results achieved, deleting the target residue, or inserting residues of the same or a different class adjacent to the located site, or combinations of options 1-3.
Alanine Scanning Mutagenesis Alanine scanning mutagenesis is a useful method for identification of certain residues or regions of the desired protein that are preferred locations or domains for mutagenesis, Cunningham and Wells (Science 244:1081-1085, 1989). In alanine scanning, a residue or group of target residues are identified charged residues such as Arg, Asp, His, Lys, and Glu) and replaced by a neutral or negatively charged amino acid (most preferably alanine or polyalanine). Replacement of an amino acid can affect the interaction SUBSTITUTE SHEET (RULE 26) WO 96/40893 PCT/US96/09122 -76of the amino acids with the surrounding aqueous environment in or outside the cell. Those domains demonstrating functional sensitivity to the substitutions are then refined by introducing further or other variants at or for the sites of substitution. Thus, while the site for introducing an amino acid sequence variation is predetermined, the nature of the mutation per se need not be predetermined. For example, to optimize the performance of a mutation at a given site, alanine scanning or random mutagenesis may be conducted at the target codon or region and the expressed desired protein subunit variants are screened for the optimal combination of desired activity.
Oligonucleotide-Mediated Mutagenesis Oligonucleotide-mediated mutagenesis is a useful method for preparing substitution, deletion, and insertion variants of DNA, see, Adelman et al., (DNA 2:183, 1983). Briefly, the desired DNA is altered by hybridizing an oligonucleotide encoding a mutation to a DNA template, where the template is the single-stranded form of a plasmid or bacteriophage containing the unaltered or native DNA sequence of the desired protein.
After hybridization, a DNA polymerase is used to synthesize an entire second complementary strand of the template that will thus incorporate the oligonucleotide primer, and will code for the selected alteration in the desired protein DNA. Generally, oligonucleotides of at least 25 nucleotides in length are used. An optimal oligonucleotide will have 12 to 15 nucleotides that are completely complementary to the template on either side of the nucleotide(s) coding for the mutation. This ensures that the oligonucleotide will hybridize properly to the single-stranded DNA template molecule. The oligonucleotides are readily synthesized using techniques known in the art such as that described by Crea et al. (Proc. Natl. Acad. Sci. USA, 75: 5765[1978]).
Cassette Mutagenesis Another method for preparing variants, cassette mutagenesis, is based on the technique described by Wells et al. (Gene, 34:315[1985]). The starting material is a plasmid (or other vector) which includes the protein subunit DNA to be mutated. The codon(s) in the protein subunit DNA to be mutated are identified. There must be a unique restriction endonuclease site on each side of the identified mutation site(s). If no such restriction sites exist, they may be generated using the above-described oligonucleotidemediated mutagenesis method to introduce them at appropriate locations in the desired protein subunit DNA. After the restriction sites have been introduced into the plasmid, the plasmid is cut at these sites to linearize it. A double-stranded oligonucleotide encoding the sequence of the DNA between the restriction sites but containing the desired mutation(s) is synthesized using standard procedures. The two strands are synthesized separately and then hybridized together using standard techniques. This double-stranded oligonucleotide is referred to as the cassette. This cassette is designed to have 3' and 5' ends that are comparable with the ends of the linearized plasmid, such that it can be directly ligated to SUBSTITUTE SHEET (RULE 26) WO 96/40893 PCT/US96/09122 -77the plasmid. This plasmid now contains the mutated desired protein subunit DNA sequence.
Combinatorial Mutagenesis Combinatorial mutagenesis can also be used to generate mutants (Ladner et al., WO 88/06630). In this method, the amino acid sequences for a group of homologs or other related proteins are aligned, preferably to promote the highest homology possible. All of the amino acids which appear at a given position of the aligned sequences can be selected to create a degenerate set of combinatorial sequences. The variegated library of variants is generated by combinatorial mutagenesis at the nucleic acid level, and is encoded by a variegated gene library. For example, a mixture of synthetic oligonucleotides can be enzymatically ligated into gene sequences such that the degenerate set of potential sequences are expressible as individual peptides, or alternatively, as a set of larger fusion proteins containing the set of degenerate sequences.
Other Modifications of H. pvlori Nucleic Acids and Polypeptides It is possible to modify the structure of an H. pylori polypeptide for such purposes as increasing solubility, enhancing stability shelf life ex vivo and resistance to proteolytic degradation in vivo). A modified H. pylori protein or peptide can be produced in which the amino acid sequence has been altered, such as by amino acid substitution, deletion, or addition as described herein.
An H. pylori peptide can also be modified by substitution of cysteine residues preferably with alanine, serine, threonine, leucine or glutamic acid residues to minimize dimerization via disulfide linkages. In addition, amino acid side chains of fragments of the protein of the invention can be chemically modified. Another modification is cyclization of the peptide.
In order to enhance stability and/or reactivity, an H. pylori polypeptide can be modified to incorporate one or more polymorphisms in the amino acid sequence of the protein resulting from any natural allelic variation. Additionally, D-amino acids, nonnatural amino acids, or non-amino acid analogs can be substituted or added to produce a modified protein within the scope of this invention. Furthermore, an H. pylori polypeptide can be modified using polyethylene glycol (PEG) according to the method of A. Sehon and co-workers (Wie et al., supra) to produce a protein conjugated with PEG. In addition, PEG can be added during chemical synthesis of the protein. Other modifications of H. pylori proteins include reduction/alkylation (Tarr, Methods of Protein Microcharacterization, J. E.
Silver ed., Humana Press, Clifton NJ 155-194 (1986)); acylation (Tarr, supra); chemical coupling to an appropriate carrier (Mishell and Shiigi, eds, Selected Methods in Cellular Immunology, WH Freeman, San Francisco, CA (1980), U.S. Patent 4,939,239; or mild formalin treatment (Marsh, (1971) Int. Arch. ofAllergy and Appl. Immunol., 41: 199 215).
SUBSTITUTE SHEET (RULE 26) WO 96/40893 PCT/US96/09122 -78- To facilitate purification and potentially increase solubility of an H. pylori protein or peptide, it is possible to add an amino acid fusion moiety to the peptide backbone. For example, hexa-histidine can be added to the protein for purification by immobilized metal ion affinity chromatography (Hochuli, E. et al., (1988) Bio/Technology, 6: 1321 1325). In addition, to facilitate isolation of peptides free of irrelevant sequences, specific endoprotease cleavage sites can be introduced between the sequences of the fusion moiety and the peptide.
To potentially aid proper antigen processing of epitopes within an H. pylori polypeptide, canonical protease sensitive sites can be engineered between regions, each comprising at least one epitope via recombinant or synthetic methods. For example, charged amino acid pairs, such as KK or RR, can be introduced between regions within a protein or fragment during recombinant construction thereof. The resulting peptide can be rendered sensitive to cleavage by cathepsin and/or other trypsin-like enzymes which would generate portions of the protein containing one or more epitopes. In addition, such charged amino acid residues can result in an increase in the solubility of the peptide.
Primary Methods for Screening Polypeptides and Analogs Various techniques are known in the art for screening generated mutant gene products. Techniques for screening large gene libraries often include cloning the gene library into replicable expression vectors, transforming appropriate cells with the resulting library of vectors, and expressing the genes under conditions in which detection of a desired activity, in this case, binding to H. pylori polypeptide or an interacting protein, facilitates relatively easy isolation of the vector encoding the gene whose product was detected. Each of the techniques described below is amenable to high through-put analysis for screening large numbers of sequences created, by random mutagenesis techniques.
Two Hybrid Systems Two hybrid assays such as the system described above (as with the other screening methods described herein), can be used to identify polypeptides, fragments or analogs of a naturally-occurring H pylori polypeptide, of cellular proteins, or of randomly generated polypeptides which bind to an H pylori protein. (The H pylori domain is used as the bait protein and the library of variants are expressed as fish fusion proteins.) In an analogous fashion, a two hybrid assay (as with the other screening methods described herein), can be used to find polypeptides which bind a H pylori polypeptide.
Display Libraries In one approach to screening assays, the candidate peptides are displayed on the surface of a cell or viral particle, and the ability of particular cells or viral particles to bind an appropriate receptor protein via the displayed product is detected in a "panning assay".
For example, the gene library can be cloned into the gene for a surface membrane protein of a bacterial cell, and the resulting fusion protein detected by panning (Ladner et al., WO SUBSTITUTE SHEET (RULE 26) WO 96/40893 PCT/US96/09122 -79- 88/06630; Fuchs et al. (1991) Bio/Technology 9:1370-1371; and Goward et al. (1992) TIBS 18:136-140). In a similar fashion, a detectably labeled ligand can be used to score for potentially functional peptide homologs. Fluorescently labeled ligands, receptors, can be used to detect homologs which retain ligand-binding activity. The use of fluorescently labeled ligands, allows cells to be visually inspected and separated under a fluorescence microscope, or, where the morphology of the cell permits, to be separated by a fluorescence-activated cell sorter.
A gene library can be expressed as a fusion protein on the surface of a viral particle.
For instance, in the filamentous phage system, foreign peptide sequences can be expressed on the surface of infectious phage, thereby conferring two significant benefits. First, since these phage can be applied to affinity matrices at concentrations well over 1013 phage per milliliter, a large number of phage can be screened at one time. Second, since each infectious phage displays a gene product on its surface, if a particular phage is recovered from an affinity matrix in low yield, the phage can be amplified by another round of infection. The group of almost identical E. coli filamentous phages M13, fd., and fl are most often used in phage display libraries. Either of the phage gIll or gVIII coat proteins can be used to generate fusion proteins without disrupting the ultimate packaging of the viral particle. Foreign epitopes can be expressed at the NH 2 -terminal end of pIII and phage bearing such epitopes recovered from a large excess of phage lacking this epitope (Ladner et al. PCT publication WO 90/02909; Garrard et al., PCT publication WO 92/09690; Marks et al. (1992) J. Biol. Chem. 267:16007-16010; Griffiths et al. (1993) EMBO J 12:725-734; Clackson et al. (1991) Nature 352:624-628; and Barbas et al. (1992) PNAS 89:4457-4461).
A common approach uses the maltose receptor of E. coli (the outer membrane protein, LamB) as a peptide fusion partner (Charbit et al. (1986) EMBO 5, 3029-3037).
Oligonucleotides have been inserted into plasmids encoding the LamB gene to produce peptides fused into one of the extracellular loops of the protein. These peptides are available for binding to ligands, to antibodies, and can elicit an immune response when the cells are administered to animals. Other cell surface proteins, OmpA (Schorr et al.
(1991) Vaccines 91, pp. 387-392), PhoE (Agterberg, et al. (1990) Gene 88, 37-45), and PAL (Fuchs et al. (1991) Bio/Tech 9, 1369-1372), as well as large bacterial surface structures have served as vehicles for peptide display. Peptides can be fused to pilin, a protein which polymerizes to form the pilus-a conduit for interbacterial exchange of genetic information (Thiry et al. (1989) Appl. Environ. Microbiol. 55, 984-993). Because of its role in interacting with other cells, the pilus provides a useful support for the presentation of peptides to the extracellular environment. Another large surface structure used for peptide display is the bacterial motive organ, the flagellum. Fusion of peptides to the subunit protein flagellin offers a dense array of many peptide copies on the host cells (Kuwajima et al. (1988) Bio/Tech. 6, 1080-1083). Surface proteins of other bacterial species have also served as peptide fusion partners. Examples include the Staphylococcus SUBSTITUTE SHEET (RULE 26) WO 96/40893 PCT/US96/09122 protein A and the outer membrane IgA protease of Neisseria (Hansson et al. (1992) J.
Bacteriol. 174, 4239-4245 and Klauser et al. (1990) EMBO J. 9, 1991-1999).
In the filamentous phage systems and the LamB system described above, the physical link between the peptide and its encoding DNA occurs by the containment of the DNA within a particle (cell or phage) that carries the peptide on its surface. Capturing the peptide captures the particle and the DNA within. An alternative scheme uses the DNAbinding protein LacI to form a link between peptide and DNA (Cull et al. (1992) PNAS USA 89:1865-1869). This system uses a plasmid containing the LacI gene with an oligonucleotide cloning site at its 3'-end. Under the controlled induction by arabinose, a LacI-peptide fusion protein is produced. This fusion retains the natural ability of LacI to bind to a short DNA sequence known as LacO operator (LacO). By installing two copies of LacO on the expression plasmid, the LacI-peptide fusion binds tightly to the plasmid that encoded it. Because the plasmids in each cell contain only a single oligonucleotide sequence and each cell expresses only a single peptide sequence, the peptides become specifically and stably associated with the DNA sequence that directed its synthesis. The cells of the library are gently lysed and the peptide-DNA complexes are exposed to a matrix of immobilized receptor to recover the complexes containing active peptides. The associated plasmid DNA is then reintroduced into cells for amplification and DNA sequencing to determine the identity of the peptide ligands. As a demonstration of the practical utility of the method, a large random library of dodecapeptides was made and selected on a monoclonal antibody raised against the opioid peptide dynorphin B. A cohort of peptides was recovered, all related by a consensus sequence corresponding to a sixresidue portion of dynorphin B. (Cull et al. (1992) Proc. Natl. Acad. Sci. U.S.A. 89-1869) This scheme, sometimes referred to as peptides-on-plasmids, differs in two important ways from the phage display methods. First, the peptides are attached to the Cterminus of the fusion protein, resulting in the display of the library members as peptides having free carboxy termini. Both of the filamentous phage coat proteins, pII and pVIII, are anchored to the phage through their C-termini, and the guest peptides are placed into the outward-extending N-terminal domains. In some designs, the phage-displayed peptides are presented right at the amino terminus of the fusion protein. (Cwirla, et al. (1990) Proc.
Natl. Acad. Sci. U.S.A. 87, 6378-6382) A second difference is the set of biological biases affecting the population of peptides actually present in the libraries. The LacI fusion molecules are confined to the cytoplasm of the host cells. The phage coat fusions are exposed briefly to the cytoplasm during translation but are rapidly secreted through the inner membrane into the periplasmic compartment, remaining anchored in the membrane by their C-terminal hydrophobic domains, with the N-termini, containing the peptides, protruding into the periplasm while awaiting assembly into phage particles. The peptides in the LacI and phage libraries may differ significantly as a result of their exposure to different proteolytic activities. The phage coat proteins require transport across the inner SUBSTITUTE SHEET (RULE 26) WO 96/40893 PCT/US96/09122 -81membrane and signal peptidase processing as a prelude to incorporation into phage.
Certain peptides exert a deleterious effect on these processes and are underrepresented in the libraries (Gallop et al. (1994) J. Med. Chem. 37(9):1233-1251). These particular biases are not a factor in the LacI display system.
The number of small peptides available in recombinant random libraries is enormous. Libraries of 107-109 independent clones are routinely prepared. Libraries as large as 1011 recombinants have been created, but this size approaches the practical limit for clone libraries. This limitation in library size occurs at the step of transforming the DNA containing randomized segments into the host bacterial cells. To circumvent this limitation, an in vitro system based on the display of nascent peptides in polysome complexes has recently been developed. This display library method has the potential of producing libraries 3-6 orders of magnitude larger than the currently available phage/phagemid or plasmid libraries. Furthermore, the construction of the libraries, expression of the peptides, and screening, is done in an entirely cell-free format.
In one application of this method (Gallop et al. (1994) 1 Med. Chem. 37(9):1233- 1251), a molecular DNA library encoding 1012 decapeptides was constructed and the library expressed in an E. coli S30 in vitro coupled transcription/translation system.
Conditions were chosen to stall the ribosomes on the mRNA, causing the accumulation of a substantial proportion of the RNA in polysomes and yielding complexes containing nascent peptides still linked to their encoding RNA. The polysomes are sufficiently robust to be affinity purified on immobilized receptors in much the same way as the more conventional recombinant peptide display libraries are screened. RNA from the bound complexes is recovered, converted to cDNA, and amplified by PCR to produce a template for the next round of synthesis and screening. The polysome display method can be coupled to the phage display system. Following several rounds of screening, cDNA from the enriched pool of polysomes was cloned into a phagemid vector. This vector serves as both a peptide expression vector, displaying peptides fused to the coat proteins, and as a DNA sequencing vector for peptide identification. By expressing the polysome-derived peptides on phage, one can either continue the affinity selection procedure in this format or assay the peptides on individual clones for binding activity in a phage ELISA, or for binding specificity in a completion phage ELISA (Barret, et al. (1992) Anal Biochem 204,357-364). To identify the sequences of the active peptides one sequences the DNA produced by the phagemid host.
Secondary Screening of Polypeptides and Analogs The high through-put assays described above can be followed by secondary screens in order to identify further biological activities which will, allow one skilled in the art to differentiate agonists from antagonists. The type of a secondary screen used will depend on the desired activity that needs to be tested. For example, an assay can be developed in SUBSTITUTE SHEET (RULE 26) WO 96/40893 PCT/US96/09122 -82which the ability to inhibit an interaction between a protein of interest and its respective ligand can be used to identify antagonists from a group of peptide fragments isolated though one of the primary screens described above.
Therefore, methods for generating fragments and analogs and testing them for activity are known in the art. Once the core sequence of interest is identified, it is routine for one skilled in the art to obtain analogs and fragments.
Peptide Mimetics of H. pylori Polypeptides The invention also provides for reduction of the protein binding domains of the subject H. pylori polypeptides to generate mimetics, e.g. peptide or non-peptide agents.
The peptide mimetics are able to disrupt binding of a polypeptide to its counter ligand, e.g., in the case of an H. pylori polypeptide binding to a naturally occurring ligand. The critical residues of a subject H pylori polypeptide which are involved in molecular recognition of a polypeptide can be determined and used to generate H pylori-derived peptidomimetics which competitively or noncompetitively inhibit binding of the H pylori polypeptide with an interacting polypeptide (see, for example, European patent applications EP-412,762A and EP-B31,080A).
For example, scanning mutagenesis can be used to map the amino acid residues of a particular H. pylori polypeptide involved in binding an interacting polypeptide, peptidomimetic compounds diazepine or isoquinoline derivatives) can be generated which mimic those residues in binding to an interacting polypeptide, and which therefore can inhibit binding of an H. pylori polypeptide to an interacting polypeptide and thereby interfere with the function of H. pylori polypeptide. For instance, non-hydrolyzable peptide analogs of such residues can be generated using benzodiazepine see Freidinger et al.
in Peptides: Chemistry and Biology, G.R. Marshall ed., ESCOM Publisher: Leiden, Netherlands, 1988), azepine see Huffman et al. in Peptides: Chemistry and Biology, G.R. Marshall ed., ESCOM Publisher: Leiden, Netherlands, 1988), substituted gama lactam rings (Garvey et al. in Peptides: Chemistry and Biology, G.R. Marshall ed., ESCOM Publisher: Leiden, Netherlands, 1988), keto-methylene pseudopeptides (Ewenson et al.
(1986) JMed Chem 29:295; and Ewenson et al. in Peptides: Structure and Function (Proceedings of the 9th American Peptide Symposium) Pierce Chemical Co. Rockland, IL, 1985), p-turn dipeptide cores (Nagai et al. (1985) Tetrahedron Lett 26:647; and Sato et al.
(1986) J Chem Soc Perkin Trans 1:1231), and P-aminoalcohols (Gordon et al. (1985) Biochem Biophys Res Commun 126:419; and Dann et al. (1986) Biochem Biophys Res Commun 134:71).
SUBSTITUTE SHEET (RULE 26) WO 96/40893 PCT/US96/09122 -83- VI. Vaccine Formulations for H pylori Nucleic Acids and Polvpeptides This invention also features vaccine compositions for protection against infection by H pylori or for treatment of H pylori infection, a gram-negative spiral microaerophilic bacterium. In one embodiment, the vaccine compositions contain one or more immunogenic components such as a surface protein from H pylori, or portion thereof, and a pharmaceutically acceptable carrier. Nucleic acids within the scope of the invention are exemplified by the nucleic acids of the invention contained in the Sequence Listing which encode H pylori surface proteins. For example, the preferred nucleic acid for a vaccine composition of the invention is isolated from the group of nucleic acids which encode cell envelope proteins as outlined in Table 1. More specifically, the amino acids of SEQ ID NO:812, SEQ ID NO:820, SEQ ID NO:880, SEQ ID NO:658, SEQ ID NO:865, SEQ ID NO:1729, SEQ ID NO:1861, or fragments thereof, can be used alone or in combination for the formulation of vaccine compositions of the invention, as well as, their corresponding nucleic acids of SEQ ID NO:977, SEQ ID NO:978, SEQ ID NO:994, SEQ ID NO:215, SEQ ID NO:989, SEQ ID NO:1278, and SEQ ID NO:1410. However, any nucleic acid encoding an immunogenic H pylori protein, or portion thereof, which is capable of expression in a cell, can be used in the present invention. These vaccines have therapeutic and prophylactic utilities.
One aspect of the invention provides a vaccine composition for protection against infection by H pylori which contains at least one immunogenic fragment of an H pylori protein and a pharmaceutically acceptable carrier. Preferred fragments include peptides of at least about 10 amino acid residues in length, preferably about 10-20 amino acid residues in length, and more preferably about 12-16 amino acid residues in length.
Immunogenic components of the invention can be obtained, for example, by screening polypeptides recombinantly produced from the corresponding fragment of the nucleic acid encoding the full-length H pylori protein. In addition, fragments can be chemically synthesized using techniques known in the art such as conventional Merrifield solid phase f-Moc or t-Boc chemistry.
In one embodiment, immunogenic components are identified by the ability of the peptide to stimulate T cells. Peptides which stimulate T cells, as determined by, for example, T cell proliferation or cytokine secretion are defined herein as comprising at least one T cell epitope. T cell epitopes are believed to be involved in initiation and perpetuation of the immune response to the protein allergen which is responsible for the clinical symptoms of allergy. These T cell epitopes are thought to trigger early events at the level of the T helper cell by binding to an appropriate HLA molecule on the surface of an antigen presenting cell, thereby stimulating the T cell subpopulation with the relevant T cell receptor for the epitope. These events lead to T cell proliferation, lymphokine secretion, local inflammatory reactions, recruitment of additional immune cells to the site of antigen/T cell interaction, and activation of the B cell cascade, leading to the production of SUBSTITUTE SHEET (RULE 26) WO 96/40893 PCT/US96/09122 -84antibodies. A T cell epitope is the basic element, or smallest unit of recognition by a T cell receptor, where the epitope comprises amino acids essential to receptor recognition approximately 6 or 7 amino acid residues). Amino acid sequences which mimic those of the T cell epitopes are within the scope of this invention.
Screening immunogenic components can be accomplished using one or more of several different assays. For example, in vitro, peptide T cell stimulatory activity is assayed by contacting a peptide known or suspected of being immunogenic with an antigen presenting cell which presents appropriate MHC molecules in a T cell culture. Presentation of an immunogenic H pylori peptide in association with appropriate MHC molecules to T cells in conjunction with the necessary costimulation has the effect of transmitting a signal to the T cell that induces the production of increased levels of cytokines, particularly of interleukin-2 and interleukin-4. The culture supernatant can be obtained and assayed for interleukin-2 or other known cytokines. For example, any one of several conventional assays for interleukin-2 can be employed, such as the assay described in Proc. Natl. Acad.
Sci USA, 86: 1333 (1989) the pertinent portions of which are incorporated herein by reference. A kit for an assay for the production of interferon is also available from Genzyme Corporation (Cambridge, MA).
Alternatively, a common assay for T cell proliferation entails measuring tritiated thymidine incorporation. The proliferation of T cells can be measured in vitro by determining the amount of 3 H-labeled thymidine incorporated into the replicating DNA of cultured cells. Therefore, the rate of DNA synthesis and, in turn, the rate of cell division can be quantified.
Vaccine compositions of the invention containing immunogenic components H. pylori polypeptide or fragment thereof or nucleic acid encoding an H. pylori polypeptide or fragment thereof) preferably include a pharmaceutically acceptable carrier. The term "pharmaceutically acceptable carrier" refers to a carrier that does not cause an allergic reaction or other untoward effect in patients to whom it is administered. Suitable pharmaceutically acceptable carriers include, for example, one or more of water, saline, phosphate buffered saline, dextrose, glycerol, ethanol and the like, as well as combinations thereof. Pharmaceutically acceptable carriers may further comprise minor amounts of auxiliary substances such as wetting or emulsifying agents, preservatives or buffers, which enhance the shelf life or effectiveness of the antibody. For vaccines of the invention containing H. pylori polypeptides, the polypeptide is coadministered with a suitable adjuvant.
It will be apparent to those of skill in the art that the therapeutically effective amount of DNA or protein of this invention will depend, inter alia, upon the administration schedule, the unit dose of antibody administered, whether the protein or DNA is administered in combination with other therapeutic agents, the immune status and health of the patient, and the therapeutic activity of the particular protein or DNA.
SUBSTITUTE SHEET (RULE 26) WO 96/40893 PCT/US96/09122 Vaccine compositions are conventionally administered parenterally, by injection, either subcutaneously or intramuscularly. Methods for intramuscular immunization are described by Wolff et al. (1990) Science 247: 1465-1468 and by Sedegah et al. (1994) Immunology 91: 9866-9870. Other modes of administration include oral and pulmonary formulations, suppositories, and transdermal applications. Oral immunization is preferred over parenteral methods for inducing protection against infection by H. pylori.
Czinn et. al. (1993) Vaccine 11: 637-642. Oral formulations include such normally employed excipients as, for example, pharmaceutical grades of mannitol, lactose, starch, magnesium stearate, sodium saccharine, cellulose, magnesium carbonate, and the like.
The vaccine compositions of the invention can include an adjuvant, including, but not limited to aluminum hydroxide; N-acetyl-muramyl--L-threonyl-D-isoglutamine (thr- MDP); N-acetyl-nor-muramyl-L-alanyl-D-isoglutamine (CGP 11637, referred to as nor- MDP); N-acetylmuramyl-L-alanyl-D-isoglutaminyl-L-alanine-2-(1'-2'-dipalmitoyl-snglycero-3-hydroxyphos-phoryloxy)-ethylamine (CGP 19835A, referred to a MTP-PE); RIBI, which contains three components from bacteria; monophosphoryl lipid A; trehalose dimycoloate; cell wall skeleton (MPL TDM CWS) in a 2% squalene/Tween emulsion; and cholera toxin. Others which may be used are non-toxic derivatives of cholera toxin, including its B subunit, and/or conjugates or genetically engineered fusions of the H. pylori polypeptide with cholera toxin or its B subunit, procholeragenoid, fungal polysaccharides, including schizophyllan, muramyl dipeptide, muramyl dipeptide derivatives, phorbol esters, labile toxin of E. coli, non-H. pylori bacterial lysates, block polymers or saponins.
Other suitable delivery methods include biodegradable microcapsules or immunostimulating complexes (ISCOMs), cochleates, or liposomes, genetically engineered attenuated live vectors such as viruses or bacteria, and recombinant (chimeric) virus-like particles, bluetongue. The amount of adjuvant employed will depend on the type of adjuvant used. For example, when the mucosal adjuvant is cholera toxin, it is suitably used in an amount of 5 pg to 50 pg, for example 10 pg to 35 pg. When used in the form of microcapsules, the amount used will depend on the amount employed in the matrix of the microcapsule to achieve the desired dosage. The determination of this amount is within the skill of a person of ordinary skill in the art.
Carrier systems in humans may include enteric release capsules protecting the antigen from the acidic environment of the stomach, and including H pylori polypeptide in an insoluble form as fusion proteins. Suitable carriers for the vaccines of the invention are enteric coated capsules and polylactide-glycolide microspheres. Suitable diluents are 0.2 N NaHCO3 and/or saline.
Vaccines of the invention can be administered as a primary prophylactic agent in adults or in children, as a secondary prevention, after successful eradication of H. pylori in an infected host, or as a therapeutic agent in the aim to induce an immune response in a SUBSTITUTE SHEET (RULE 26) WO 96/40893 PCT/US96/09122 -86susceptible host to prevent infection by H. pylori. The vaccines of the invention are administered in amounts readily determined by persons of ordinary skill in the art. Thus, for adults a suitable dosage will be in the range of 10 ug to 10 g, preferably 10 ug to 100 mg, for example 50 tg to 50 mg. A suitable dosage for adults will also be in the range of p.g to 500 mg. Similar dosage ranges will be applicable for children. Those skilled in the art will recognize that the optimal dose may be more or less depending upon the patient's body weight, disease, the route of administration, and other factors. Those skilled in the art will also recognize that appropriate dosage levels can be obtained based on results with known oral vaccines such as, for example, a vaccine based on an E. coli lysate (6 mg dose daily up to total of 540 mg) and with an enterotoxigenic E. coli purified antigen (4 doses of 1 mg) (Schulman et al., J. Urol. 150:917-921 (1993); Boedecker et al., American Gastroenterological Assoc. 999:A-222 (1993)). The number of doses will depend upon the disease, the formulation, and efficacy data from clinical trials. Without intending any limitation as to the course of treatment, the treatment can be administered over 3 to 8 doses for a primary immunization schedule over 1 month (Boedeker, American Gastroenterological Assoc. 888:A-222 (1993)).
In a preferred embodiment, a vaccine composition of the invention can be based on a killed whole E. coli preparation with an immunogenic fragment of an H pylori protein of the invention expressed on its surface or it can be based on an E. coli lysate, wherein the killed E. coli acts as a carrier or an adjuvant.
It will be apparent to those skilled in the art that some of the vaccine compositions of the invention are useful only for preventing H. pylori infection, some are useful only for treating H. pylori infection, and some are useful for both preventing and treating H pylori infection. In a preferred embodiment, the vaccine composition of the invention provides protection against H. pylori infection by stimulating humoral and/or cell-mediated immunity against H. pylori. It should be understood that amelioration of any of the symptoms of H. pylori infection is a desirable clinical goal, including a lessening of the dosage of medication used to treat H pylori-caused disease, or an increase in the production of antibodies in the serum or mucous of patients.
VII. Antibodies Reactive With H. pylori Polypeptides The invention also includes antibodies specifically reactive with the subject H.
pylori polypeptide. Anti-protein/anti-peptide antisera or monoclonal antibodies can be made by standard protocols (See, for example, Antibodies: A Laboratory Manual ed. by Harlow and Lane (Cold Spring Harbor Press: 1988)). A mammal such as a mouse, a hamster or rabbit can be immunized with an immunogenic form of the peptide. Techniques for conferring immunogenicity on a protein or peptide include conjugation to carriers or other techniques well known in the art. An immunogenic portion of the subject H pylori polypeptide can be administered in the presence of adjuvant. The progress of immunization SUBSTITUTE SHEET (RULE 26) WO 96/40893 PCT/US96/09122 -87can be monitored by detection of antibody titers in plasma or serum. Standard ELISA or other immunoassays can be used with the immunogen as antigen to assess the levels of antibodies.
In a preferred embodiment, the subject antibodies are immunospecific for antigenic determinants of the H pylori polypeptides of the invention, e.g. antigenic determinants of a polypeptide of the invention contained in the Sequence Listing, or a closely related human or non-human mammalian homolog 90% homologous, more preferably at least homologous). In yet a further preferred embodiment of the invention, the anti-H pylori antibodies do not substantially cross react react specifically) with a protein which is for example, less than 80% percent homologous to a sequence of the invention contained in the Sequence Listing. By "not substantially cross react", it is meant that the antibody has a binding affinity for a non-homologous protein which is less than 10 percent, more preferably less than 5 percent, and even more preferably less than 1 percent, of the binding affinity for a protein of the invention contained in the Sequence Listing. In a most preferred embodiment, there is no crossreactivity between bacterial and mammalian antigens.
The term antibody as used herein is intended to include fragments thereof which are also specifically reactive with H. pylori polypeptides. Antibodies can be fragmented using conventional techniques and the fragments screened for utility in the same manner as described above for whole antibodies. For example, F(ab') 2 fragments can be generated by treating antibody with pepsin. The resulting F(ab') 2 fragment can be treated to reduce disulfide bridges to produce Fab' fragments. The antibody of the invention is further intended to include bispecific and chimeric molecules having an anti-H pylori portion.
Both monoclonal and polyclonal antibodies (Ab) directed against H. pylori polypeptides or H pylori polypeptide variants, and antibody fragments such as Fab' and F(ab')2, can be used to block the action of H. pylori polypeptide and allow the study of the role of a particular H. pylori polypeptide of the invention in aberrant or unwanted intracellular signaling, as well as the normal cellular function of the H. pylori and by microinjection of anti-H pylori polypeptide antibodies of the present invention.
Antibodies which specifically bind H. pylori epitopes can also be used in immunohistochemical staining of tissue samples in order to evaluate the abundance and pattern of expression of H pylori antigens. Anti H. pylori polypeptide antibodies can be used diagnostically in immuno-precipitation and immuno-blotting to detect and evaluate H pylori levels in tissue or bodily fluid as part of a clinical testing procedure. Likewise, the ability to monitor H pylori polypeptide levels in an individual can allow determination of the efficacy of a given treatment regimen for an individual afflicted with such a disorder.
The level of an H. pylori polypeptide can be measured in cells found in bodily fluid, such as in urine samples or can be measured in tissue, such as produced by gastric biopsy.
Diagnostic assays using anti-H pylori antibodies can include, for example, immunoassays SUBSTITUTE SHEET (RULE 26) WO 96/40893 PCT/US96/09122 -88designed to aid in early diagnosis of H. pylori infections. The present invention can also be used as a method of detecting antibodies contained in samples from individuals infected by this bacterium using specific H. pylori antigens.
Another application of anti-H. pylori polypeptide antibodies of the invention is in the immunological screening of cDNA libraries constructed in expression vectors such as Xgtl 1, kgtl8-23, ?.ZAP, and kORF8. Messenger libraries of this type, having coding sequences inserted in the correct reading frame and orientation, can produce fusion proteins. For instance, kgtl 1 will produce fusion proteins whose amino termini consist of B-galactosidase amino acid sequences and whose carboxy termini consist of a foreign polypeptide. Antigenic epitopes of a subject H pylori polypeptide can then be detected with antibodies, as, for example, reacting nitrocellulose filters lifted from infected plates with anti-H pylori polypeptide antibodies. Phage, scored by this assay, can then be isolated from the infected plate. Thus, the presence of H. pylori gene homologs can be detected and cloned from other species, and alternate isoforms (including splicing variants) can be detected and cloned.
VIII. Kits Containing Nucleic Acids, Polypeptides or Antibodies of the Invention The nucleic acid, polypeptides and antibodies of the invention can be combined with other reagents and articles to form kits. Kits for diagnostic purposes typically comprise the nucleic acid, polypeptides or antibodies in vials or other suitable vessels. Kits typically comprise other reagents for performing hybridization reactions, polymerase chain reactions (PCR), or for reconstitution of lyophilized components, such as aqueous media, salts, buffers, and the like. Kits may also comprise reagents for sample processing such as detergents, chaotropic salts and the like. Kits may also comprise immobilization means such as particles, supports, wells, dipsticks and the like. Kits may also comprise labeling means such as dyes, developing reagents, radioisotopes, fluorescent agents, luminescent or chemiluminescent agents, enzymes, intercalating agents and the like. With the nucleic acid and amino acid sequence information provided herein, individuals skilled in art can readily assemble kits to serve their particular purpose. Kits further can include instructions for use.
IX. Drug Screening Assays Using H. pylori Polypeptides By making available purified and recombinant H. pylori polypeptides, the present invention provides assays which can be used to screen for drugs which are either agonists or antagonists of the normal cellular function, in this case, of the subject H. pylori polypeptides, or of their role in intracellular signaling. Such inhibitors or potentiators may be useful as new therapeutic agents to combat H. pylori infections in humans. A variety of assay formats will suffice and, in light of the present inventions, will be comprehended by the skilled artisan.
SUBSTITUTE SHEET (RULE 26) WO 96/40893 PCT/US96/09122 -89- In many drug screening programs which test libraries of compounds and natural extracts, high throughput assays are desirable in order to maximize the number of compounds surveyed in a given period of time. Assays which are performed in cell-free systems, such as may be derived with purified or semi-purified proteins, are often preferred as "primary" screens in that they can be generated to permit rapid development and relatively easy detection of an alteration in a molecular target which is mediated by a test compound. Moreover, the effects of cellular toxicity and/or bioavailability of the test compound can be generally ignored in the in vitro system, the assay instead being focused primarily on the effect of the drug on the molecular target as may be manifest in an alteration of binding affinity with other proteins or change in enzymatic properties of the molecular target. Accordingly, in an exemplary screening assay of the present invention, the compound of interest is contacted with an isolated and purified H. pylori polypeptide.
Screening assays can be constructed in vitro with a purified H. pylori polypeptide or fragment thereof, such as an H. pylori polypeptide having enzymatic activity, such that the activity of the polypeptide produces a detectable reaction product. The efficacy of the compound can be assessed by generating dose response curves from data obtained using various concentrations of the test compound. Moreover, a control assay can also be performed to provide a baseline for comparison. Suitable products include those with distinctive absorption, fluorescence, or chemi-luminescence properties, for example, because detection may be easily automated. A variety of synthetic or naturally occurring compounds can be tested in the assay to identify those which inhibit or potentiate the activity of the H. pylori polypeptide. Some of these active compounds may directly, or with chemical alterations to promote membrane permeability or solubility, also inhibit or potentiate the same activity enzymatic activity) in whole, live H. pylori cells.
EXEMPLIFICATION
I. Cloning and Sequencing of H. pylori DNA H. pylori chromosomal DNA was isolated according to a basic DNA protocol outlined in Schleif R.F. and Wensink Practical Methods in Molecular Biology, p.98, Springer-Verlag, NY., 1981, with minor modifications. Briefly, cells were pelleted, resuspended in TE (10 mM Tris, 1 mM EDTA, pH 7.6) and GES lysis buffer (5.1 M guanidium thiocyanate, 0.1 M EDTA, pH 8.0, 0.5% N-laurylsarcosine) was added.
Suspension was chilled and ammonium acetate (NH 4 Ac) was added to final concentration of 2.0 M. DNA was extracted, first with chloroform, then with phenol-chloroform, and reextracted with chloroform. DNA was precipitated with isopropanol, washed twice with EtOH, dried and resuspended in TE.
Following isolation whole genomic H. pylori DNA was nebulized (Bodenteich et al., Automated DNA Sequencing and Analysis Venter, Academic Press, 1994) to SUBSTITUTE SHEET (RULE 26) WO 96/40893 PCT/US96/09122 a median size of 2000 bp. After nebulization, the DNA was concentrated and separated on a standard 1% agarose gel. Several fractions, corresponding to approximate sizes 900-1300 bp, 1300-1700 bp, 1700-2200 bp, 2200-2700 bp, were excised from the gel and purified by the GeneClean procedure (Bioll01, Inc.).
The purified DNA fragments were then blunt-ended using T4 DNA polymerase.
The healed DNA was then ligated to unique BstXI-linker adapters TCTAGACCACCTGC and 5' GTGGTCTAGA in 100-1000 fold molar excess). These linkers are complimentary to the BstXI-cut pMPX vectors, while the overhang is not selfcomplimentary. Therefore, the linkers will not concatemerize nor will the cut-vector religate itself easily. The linker-adopted inserts were separated from the unincorporated linkers on a 1% agarose gel and purified using GeneClean. The linker-adopted inserts were then ligated to each of the 20 pMPX vectors to construct a series of "shotgun" subclone libraries. The vectors contain an out-of-frame lacZ gene at the cloning site which becomes in-frame in the event that an adapter-dimer is cloned, allowing these to be avoided by their blue-color.
All subsequent steps were based on the multiplex DNA sequencing protocols outlined in Church G.M. and Kieffer-Higgins Science 240:185-188, 1988. Only major modifications to the protocols are highlighted. Briefly, each of the 20 vectors was then transformed into DH5a competent cells (Gibco/BRL, DH5a transformation protocol). The libraries were assessed by plating onto antibiotic plates containing ampicillin, methicillin and IPTG/Xgal. The plates were incubated overnight at 370C. Successful transformants were then used for plating of clones and pooling into the multiplex pools. The clones were picked and pooled into 40 ml growth medium cultures. The cultures were grown overnight at 370C. DNA was purified using the Qiagen Midi-prep kits and Tip-100 columns (Qiagen, Inc.). In this manner, 100 p.g of DNA was obtained per pool. Fifteen 96-well plates of DNA were generated to obtain a 5-10 fold sequence redundancy assuming 250- 300 base average read-lengths.
These purified DNA samples were then sequenced using the multiplex DNA sequencing based on chemical degradation methods (Church G.M. and Kieffer-Higgins S., Science 240:185-188, 1988) or by Sequithrem (Epicenter Technologies) dideoxy sequencing protocols. The sequencing reactions were electrophoresed and transferred onto nylon membranes by direct transfer electrophoresis from 40 cm gels (Richterich P. and Church Methods in Enzymology 218:187-222, 1993) or by electroblotting (Church, supra). 24 samples were run per gel. 45 successful membranes were produced by chemical sequencing and 8 were produced by dideoxy sequencing. The DNA was covalently bound to the membranes by exposure to ultraviolet light, and hybridized with labeled oligonucleotides complimentary to tag sequences on the vectors (Church, supra). The membranes were washed to rinse off non-specifically bound probe, and exposed to X-ray film to visualize individual sequence ladders. After autoradiography, the hybridized probe SUBSTITUTE SHEET (RULE 26) WO 96/40893 PCT/US96/09122 -91was removed by incubation at 650 C, and the hybridization cycle repeated with another tag sequence until the membrane had been probed 38 times for chemical sequencing membranes and 10 times for the dideoxy sequencing membranes. Thus, each gel produced a large number of films, each containing new sequencing information. Whenever a new blot was processed, it was initially probed for an internal standard sequence added to each of the pools.
Digital images of the films were generated using a laser-scanning densitometer (Molecular Dynamics, Sunnyvale, CA). The digitized images were processed on computer workstations (VaxStation 4000's) using the program REPLICATM (Church et al., Automated DNA Sequencing and Analysis Venter, Academic Press, 1994).
Image processing included lane straightening, contrast adjustment to smooth out intensity differences, and resolution enhancement by iterative gaussian deconvolution. The sequences were then automatically picked in REPLICATM and displayed for interactive proofreading before being stored in a project database. The proofreading was accomplished by a quick visual scan of the film image followed by mouse clicks on the bands of the displayed image to modify the base calls. Many of the sequence errors could be detected and corrected because multiple sequence reads covering the same portion of the genomic DNA provide adequate sequence redundancy for editing. Each sequence automatically received an identification number (corresponding to microtiter plate, probe information, and lane set number). This number serves as a permanent identifier of the sequence so it is always possible to identify the original of any particular sequence without recourse to a specialized database.
Routine assembly of H. pylori sequences was done using the program FALCON (Church, Church et al., Automated DNA Sequenicng and Analysis Venter, ed.), Academic Press, 1994). This program has proven to be fast and reliable for most sequences. The assembled contigs were displayed using a modified version of GelAssemble, developed by the Genetics Computer Group (GCG) (Devereux et al., Nucleic Acid Res. 12:387-95, 1984) that interacts with REPLICA T M This provided for an integrated editor that allows multiple sequence gel images to be instantaneously called up from the REPLICA T M database and displayed to allow rapid scanning of contigs and proofreading of gel traces where discrepancies occurred between different sequence reads in the assembly.
II. Identification, cloning and expression of recombinant H. pylori DNA sequences To facilitate the cloning, expression and purification of membrane and secreted proteins from H. pylori a powerful gene expression system, the pET System (Novagen), for cloning and expression of recombinant proteins in E. coli, was selected. Also, a DNA sequence encoding a peptide tag, the His-Tag, was fused to the 3' end of DNA sequences of interest in order to facilitate purification of the recombinant protein products. The 3' end SUBSTITUTE SHEET (RULE 26) WO 96/40893 PCT/US96/09122 -92was selected for fusion in order to avoid alteration of any 5' terminal signal sequence. The exception to the above was ppiB, a gene cloned for use as a control in the expression studies. In this study, the sequence for H. pylori ppiB contains a DNA sequence encoding a His-Tag fused to the 5' end of the full length gene, because the protein product of this gene does not contain a signal sequence and is expressed as a cytosolic protein.
PCR Amplification and cloning of DNA sequences containing ORF'sfor membrane and secreted proteins from the J99 Strain ofHelicobacter pylori.
Sequences chosen (from the list of the DNA sequences of the invention) for cloning from the J99 strain of H pylori were prepared for amplification cloning by polymerase chain reaction (PCR). Synthetic oligonucleotide primers (Table 4) specific for the 5' and 3' ends of open reading frames (ORFs) were designed and purchased (GibcoBRL Life Technologies, Gaithersburg, MD, USA). All forward primers (specific for the 5' end of the sequence) were designed to include an Ncol cloning site at the extreme 5' terminus, except for HpSeq. 4821082 (SEQ ID NO: 820) where NdeI was used. These primers were designed to permit initiation of protein translation at a methionine residue followed by a valine residue and the coding sequence for the remainder of the native H pylori DNA sequence. An exception is H pylori sequence 4821082 (SEQ ID NO: 820) where the initiator methionine is immediately followed by the remainder of the native H. pylori DNA sequence. All reverse primers (specific for the 3' end of any H pylori ORF) included a EcoRI site at the extreme 5' terminus to permit cloning of each H pylori sequence into the reading frame of the pET-28b. The pET-28b vector provides sequence encoding an additional 20 carboxy-terminal amino acids (only 19 amino acids in HpSeq. 26380318 (SEQ ID NO: 658)and HpSeq. 14640637 (SEQ ID NO: 447)) including six histidine residues (at the extreme C-terminus), which comprise the His-Tag. An exception to the above, as noted earlier, is the vector construction for the ppiB gene. A synthetic oligonucleotide primer specific for the 5' end of ppiB gene encoded a BamHI site at its extreme 5' terminus and the primer for the 3' end of the ppiB gene encoded a Xhol site at its extreme 5' terminus.
SUBSTITUTE SHEET (RULE 26) WO 96/40893 WO 9640893PC-r/US96/09122 -93- TABLE 4 Oligonucleotide primers used for PCR ampilification of H Pylori DNA sequences Outer membrane Proteins Forward primer 5' to 3' Reverse Primer 5' to 3' 16225006 (SEQ ID NO: 5'-TATACCATGGTGGG 5 t
-ATGAATTCGAGTAAG
465) CGCTAA-3' (SEQ ID GATTTTTG-3' (SEQ ID 1897) NO: 1898) 26054702 (SEQ ID NO: 5'-TTAACCATGGTGAAA 5'-TAGAATTCGC ATAAC 649) AGCGATA-3- (SEQ ID GATCAATC-3' (SEQ ID 1899) NO:1900) 7116626 (SEQ ID NO: 865) 5'-ATATCCATGGTGAGT TTGATGA-3' (SEQ ID TATTTTGCCA-Y (SEQ ID 190 1) NO: 1902) 29479681 (SEQ ID NO: 5'-AATTCCATGGTGGGG 677) GCTATG-3' (SEQ ID CCAAAATC-3' (SEQ ID 1903) NO: 1904) 14640637 (SEQ ID NO: 5'-AATTCCATGGTGCAT 447) AACTTCCATT-3' (SEQ ID TCCAAATGGA-3' (SEQ 1905) ID NO: 1906) Periplasmic/ Secreted Proteins 30100332 (SEQ ID NO: 5'-ATTTCCATGGTCATG 685) TCTCATATT-3' (SEQ ID TATTCCAC-3' (SEQ ID 1907) NO: 1908) 4721061 (SEQ ID NO: 812) 5'-AACCATGGTGATTT TAAGCATTGAAAG-3' AAATTTTTTAACAG-3' ID NO: 1909) (SEQ ID NO: 19 Other Surface Proteins 4821082 (SEQ ID NO: 820) 5'-GATCATCCATATGTT ATCTTCTAAT-3' (SEQ ID TAACCCTG-3' (SEQ ID NO: 1911) NO:1912) 978477 (SEQ ID NO: 880) 5'-TATACCATGGTGAA ATTTTTTCTTTTA-3' TCTTGTAAAAG-3' (SEQ (SEQ IDNO: 1913) ID NO: 1914) Inner Membrane Protein 26380318 (SEQ ID NO: 5'-TATACCATGGTGAT 658) GGACAAACTC-3' (SEQ GGGGCGATA-3' (SEQ ID ID NO: 1915) NO:1916) Cytoplasmic Protein ppi 5'-TTATGGATCCAAAC CAATTAAAACT-3 t (SEQ GAGAAGGGC-3' (SEQ ID NO: 1917) NO: 1918) SUBSTITUTE SHEET (RULE 26) WO 96/40893 PCTIUS96/09122 -94- Genomic DNA prepared from the J99 strain of H. pylori (ATCC #55679) was used as the source of template DNA for PCR amplification reactions (Current Protocols in Molecular Biology, John Wiley and Sons, Inc., F. Ausubel et al., eds., 1994). To amplify a DNA sequence containing an H. pylori ORF, genomic DNA (50 nanograms) was introduced into a reaction vial containing 2 mM MgCl 2 1 micromolar synthetic oligonucleotide primers (forward and reverse primers) complementary to and flanking a defined H. pylori ORF, 0.2 mM of each deoxynucleotide triphosphate; dATP, dGTP, dCTP, dTTP and 2.5 units of heat stable DNA polymerase (Amplitaq, Roche Molecular Systems, Inc., Branchburg, NJ, USA) in a final volume of 100 microliters. The following thermal cycling conditions were used to obtain amplified DNA products for each ORF using a Perkin Elmer Cetus/ GeneAmp PCR System 9600 thermal cycler: Sequences 26054702 (SEQ ID NO: 649), 7116626 (SEQ ID NO: 865), 29479681 (SEQ ID NO: 677), 30100332 (SEQ ID NO: 685), 4821082 (SEQ ID NO: 820) and 978477 (SEQ ID NO: 880); Denaturation at 94 0 C for 2 min, 2 cycles at 94 0 C for 15 sec, 30 0 C for 15 sec and 72 0 C for 1.5 min 23 cycles at 94 0 C for 15 sec, 55 0 C for 15 sec and 72 0 C for 1.5 min Reactions were concluded at 72 0 C for 6 minutes.
Sequence 16225006 (SEQ ID NO: 465); Denaturation at 94 0 C for 2 min, cycles at 95 0 C for 15 sec, 55 0 C for 15 sec and 72 0 C for 1.5 min Reaction was concluded at 72 0 C for 6 minutes.
Sequence 4721061 (SEQ ID NO: 812); Denaturation at 94 0 C for 2 min, 2 cycles at 94 0 C for 15 sec, 36 0 C for 15 sec and 72 0 C for 1.5 min 23 cycles at 94 0 C for 15 sec, 60 0 C for 15 sec and 72 0 C for 1.5 min Reactions were concluded at 72 0 C for 6 minutes.
Sequence 26380318 (SEQ ID NO: 658); Denaturation at 94 0 C for 2 min, 2 cycles at 94 0 C for 15 sec, 38 0 C for 15 sec and 72 0 C for 1.5 min 23 cycles at 94 0 C for 15 sec, 62 0 C for 15 sec and 72 0 C for 1.5 min Reactions were concluded at 72 0 C for 6 minutes.
SUBSTITUTE SHEET (RULE 26) WO 96/40893 PCT/US96/09122 Sequence 14640637 (SEQ ID NO: 447); Denaturation at 94 0 C for 2 min, 2 cycles at 94 0 C for 15 sec, 33 0 C for 15 sec and 72 0 C for 1.5 min cycles at 94 0 C for 15 sec, 55 0 C for 15 sec and 72 0 C for 1.5 min Reactions were concluded at 72 0 C for 6 minutes.
Conditions for amplification of H. pylori ppiB; Denaturation at 94 0 C for 2 min, 2 cycles at 94 0 C for 15 sec, 32 0 C for 15 sec and 72 0 C for 1.5 min 25 cycles at 94 0 C for 15 sec, 56 0 C for 15 sec and 72 0 C for 1.5 min Reactions were concluded at 72 0 C for 6 minutes Upon completion of thermal cycling reactions, each sample of amplified DNA was washed and purified using the Qiaquick Spin PCR purification kit (Qiagen, Gaithersburg, MD, USA). All amplified DNA samples were subjected to digestion with the restriction endonucleases, Ncol and EcoRI (New England BioLabs, Beverly, MA, USA), or in the case of HpSeq. 4821082 (SEQ ID NO: 820), with Ndel and EcoRI (Current Protocols in Molecular Biology, John Wiley and Sons, Inc., F. Ausubel et al., eds., 1994). DNA samples were then subjected to electrophoresis on 1.0 NuSeive (FMC BioProducts, Rockland, ME USA) agarose gels. DNA was visualized by exposure to ethidium bromide and long wave uv irradiation. DNA contained in slices isolated from the agarose gel was purified using the Bio 101 GeneClean Kit protocol (Bio 101 Vista, CA, USA) Cloning ofH. pylori DNA sequences into the pET-28b prokaryotic expression vector.
The pET-28b vector was prepared for cloning by digestion with Ncol and EcoRI, or in the case of H. pylori sequence 4821082 (SEQ ID NO: 820) with Ndel and EcoRI (Current Protocols in Molecular Biology, John Wiley and Sons, Inc., F. Ausubel et al., eds., 1994). In the case of cloning ppiB, the pET-28a vector, which encodes a His-Tag that can be fused to the 5' end of an inserted gene, was used and the cloning site prepared for cloning with the ppiB gene by digestion with BamHI and Xhol restriction endonucleases.
Following digestion, DNA inserts were cloned (Current Protocols in Molecular Biology, John Wiley and Sons, Inc., F. Ausubel et al., eds., 1994) into the previously digested pET-28b expression vector, except for the amplified insert for ppiB, which was cloned into the pET-28a expression vector. Products of the ligation reaction were then used to transform the BL21 strain of E. coli (Current Protocols in Molecular Biology, John Wiley and Sons, Inc., F. Ausubel et al., eds., 1994) as described below.
Transformation of competent bacteria with recombinant plasmids Competent bacteria, E coli strain BL21 or E. coli strain BL21 (DE3), were transformed with recombinant pET expression plasmids carrying the cloned H pylori SUBSTITUTE SHEET (RULE 26) WO 96/40893 PCT/US96/09122 -96sequences according to standard methods (Current Protocols in Molecular, John Wiley and Sons, Inc., F. Ausubel et al., eds., 1994). Briefly, 1 microliter of ligation reaction was mixed with 50 microliters of electrocompetent cells and subjected to a high voltage pulse, after which, samples were incubated in 0.45 milliliters SOC medium yeast extract, 2.0 tryptone, 10 mM NaCl, 2.5 mM KC1, 10 mM MgC12, 10 mM MgSO4 and 20, mM glucose) at 37 0 C with shaking for 1 hour. Samples were then spread on LB agar plates containing 25 microgram/ml kanamycin sulfate for growth overnight. Transformed colonies of BL21 were then picked and analyzed to evaluate cloned inserts as described below.
Identification ofrecombinant pET expression plasmids carrying H. pylori sequences Individual BL21 clones transformed with recombinant pET-28b-H.pylori ORFs were analyzed by PCR amplification of the cloned inserts using the same forward and reverse primers, specific for each H pylori sequence, that were used in the original PCR amplification cloning reactions. Successful amplification verified the integration of the H.
pylori sequences in the expression vector (Current Protocols in Molecular Biology, John Wiley and Sons, Inc., F. Ausubel et al., eds., 1994).
Isolation and Preparation ofplasmid DNA from BL21 transformants Individual clones of recombinant pET-28b vectors carrying properly cloned H.
pylori ORFs were picked and incubated in 5 mis of LB broth plus 25 microgram/ml kanamycin sulfate overnight. The following day plasmid DNA was isolated and purified using the Qiagen plasmid purification protocol (Qiagen Inc., Chatsworth, CA, USA).
Expression of recombinant H pylori sequences in E. coli The pET vector can be propagated in any E. coli K-12 strain e.g. HMS174, HB101, JM109, DH5, etc. for the purpose of cloning or plasmid preparation. Hosts for expression include E. coli strains containing a chromosomal copy of the gene for T7 RNA polymerase.
These hosts are lysogens of bacteriophage DE3, a lambda derivative that carries the lacI gene, the lacUV5 promoter and the gene for T7 RNA polymerase. T7 RNA polymerase is induced by addition of isopropyl-B-D-thiogalactoside (IPTG), and the T7 RNA polymerase transcribes any target plasmid, such as pET-28b, carrying a T7 promoter and a gene of interest. Strains used include: BL21(DE3) (Studier, Rosenberg, Dunn, and Dubendorff, J.W. (1990) Meth. Enzymol. 185, 60-89).
To express recombinant H pylori sequences, 50 nanograms of plasmid DNA isolated as described above was used to transform competent BL21 (DE3) bacteria as described above (provided by Novagen as part of the pET expression system kit). The lacZ gene (beta-galactosidase) was expressed in the pET-System as described for the H. pylori recombinant constructions. Transformed cells were cultured in SOC medium for 1 hour, SUBSTITUTE SHEET (RULE 26) WO 96/40893 PCT/US96/09122 -97and the culture was then plated on LB plates containing 25 micrograms/ml kanamycin sulfate. The following day, bacterial colonies were pooled and grown in LB medium containing kanamycin sulfate (25 micrograms/ml) to an optical density at 600 nM of 0.5 to O.D. units, at which point, 1 millimolar IPTG was added to the culture for 3 hours to induce gene expression of the H. pylori recombinant DNA constructions.
After induction of gene expression with IPTG, bacteria were pelleted by centrifugation in a Sorvall RC-3B centrifuge at 3500 x g for 15 minutes at 4 0 C. Pellets were resuspended in 50 milliliters of cold 10 mM Tris-HCl, pH 8.0, 0.1 M NaCl and 0.1 mM EDTA (STE buffer). Cells were then centrifuged at 2000 x g for 20 min at 4 0 C. Wet pellets were weighed and frozen at -80 0 C until ready for protein purification.
III. Purification of recombinant proteins from E. coli Analytical Methods The concentrations of purified protein preparations were quantified spectrophotometrically using absorbance coefficients calculated from amino acid content (Perkins, S.J. 1986 Eur. J. Biochem. 157, 169-180). Protein concentrations were also measured by the method of Bradford, M.M. (1976) Anal. Biochem. 72, 248-254, and Lowry, Rosebrough, Farr, A.L. Randall, R.J. (1951) J. Biol. Chem. 193, pages 265-275, using bovine serum albumin as a standard.
SDS-polyacrylamide gels (12% or 4.0 to 25 acrylamide gradient gels) were purchased from BioRad (Hercules, CA, USA), and stained with Coomassie blue.
Molecular weight markers included rabbit skeletal muscle myosin (200 kDa), E. coli galactosidase (116 kDa), rabbit muscle phosphorylase B (97.4 kDa), bovine serum albumin (66.2 kDa), ovalbumin (45 kDa), bovine carbonic anhydrase (31 kDa), soybean trypsin inhibitor (21.5 kDa), egg white lysozyme (14.4 kDa) and bovine aprotinin (6.5 kDa).
1. Purification of soluble proteins All steps were carried out at 4 0 C. Frozen cells were thawed, resuspended in volumes of lysis buffer (20 mM Tris, pH 7.9, 0.5 M NaCl, 5 mM imidazole with glycerol, 0.1 2-mercaptoethanol, 200 u.g/ ml lysozyme, 1 mM phenylmethylsulfonyl fluoride (PMSF), and 10 ug/ml each of leupeptin, aprotinin, pepstatin, L-1-chloro-3-[4tosylamido]-7-amino-2-heptanone (TLCK), L-1-chloro-3-[4-tosylamido]-4-phenyl-2butanone (TPCK), and soybean trypsin inhibitor, and ruptured by several passages through a small volume microfluidizer (Model M-1 10S, Microfluidics International Corporation, Newton, MA). The resultant homogenate was made 0.1 Brij 35, and centrifuged at 100,000 x g for 1 hour to yield a clear supernatant (crude extract).
Following filtration through a 0.8 gm Supor filter (Gelman Sciences, FRG) the crude extract was loaded directly onto a Ni 2 nitrilotriacetate-agarose (NTA) with a milliliter bed volume (Hochuli, Dbeli, and Schacheer, A. (1987) J. Chromatography SUBSTITUTE SHEET (RULE 26) WO 96/40893 PCT/US96/09122 -98- 411, 177-184) pre-equilibrated in lysis buffer containing 10 glycerol, 0.1 Brij 35 and 1 mM PMSF. The column was washed with 250 ml (50 bed volumes) of lysis buffer containing 10 glycerol, 0.1 Brij 35, and was eluted with sequential steps of lysis buffer containing 10 glycerol, 0.05 Brij 35, 1 mM PMSF, and 20, 100, 200, and 500 mM imidazole in succession. Fractions were monitored by absorbance at OD 2 80 nm, and peak fractions were analyzed by SDS-PAGE. Fractions containing the recombinant protein eluted at 100 mM imidazole.
Recombinant protein 14640637 (SEQ ID NO: 447) and proteins, beta-galactosidase (lacZ) and peptidyl-prolyl cis-trans isomerase (ppiB) Fractions containing the recombinant proteins from the Ni2+-NTA-agarose columns were pooled and then concentrated to approximately 5 ml by centrifugal filtration Amicon, MA), and loaded directly onto a 180-ml column (1.6 X 91 cm) of Sephacryl S-100 HR gel filtration medium equilibrated in Buffer A (10 mM Hepes, pH 150 mM NaC1, 0.1 mM EGTA) and run in Buffer A at 18 ml/h. Fractions containing the recombinant protein were identified by absorbance at 280 nm and analyzed by SDS-PAGE.
Fractions were pooled and concentrated by centrifugal filtration.
Recombinant protein 7116626 (SEQ ID NO: 865) Fractions containing the recombinant protein from the Ni 2 -NTA-agarose column were pooled and dialyzed overnight against 1 liter of dialysis buffer (10 mM MOPS, pH 50 mM NaCl, 0.1 mM EGTA, 0.02% Brij 35 and 1 mM PMSF). In the morning, a fine white precipitate was removed by centrifugation and the resulting supernatant was loaded onto an 8 ml (8 x 75 mm) MonoS high performance liquid chromatography column (Pharmacia Biotechnology, Inc., Piscataway, NJ, USA) equilibrated in buffer B (10 mM MOPS, pH 6.5, 0.1 mM EGTA) containing 50 mM NaC1. The column was washed with bed volumes of buffer B containing 50 mM NaCl, and developed with a 50-ml linear gradient of increasing NaCl (50 to 500 mM). Recombinant protein 7116626 (SEQ ID NO: 865) eluted as a sharp peak at 300 mM NaC1.
2. Purification of insoluble proteins from inclusion bodies The following steps were carried out at 4 0 C. Cell pellets were resuspended in lysis buffer with 10% glycerol 200 tg/ ml lysozyme, 5 mM EDTA, 1mM PMSF and 0.1 mercaptoethanol. After passage through the cell disrupter, the resulting homogenate was made 0.2 deoxycholate, stirred 10 minutes, then centrifuged at 20,000 x g, for 30 min.
The pellets were washed with lysis buffer containing 10 glycerol, 10 mM EDTA, 1% Triton X-100, 1 mM PMSF and 0.1% -mercaptoethanol, followed by several washes with lysis buffer containing 1 M urea, 1 mM PMSF and 0.1 2-mercaptoethanol. The resulting SUBSTITUTE SHEET (RULE 26) WO 96/40893 PCT/US96/09122 -99white pellet was composed primarily of inclusion bodies, free of unbroken cells and membranous materials..
Recombinant proteins 26054702 (SEQ ID NO: 649), 16225006 (SEQ ID NO: 465), 30100332 (SEQ ID NO: 685), 4721061 (SEQ ID NO: 812) The following steps were carried out at room temperature. Purified inclusion bodies were dissolved in 20 ml 8.0 M urea in lysis buffer with 1 mM PMSF and 0.1 2mercaptoethanol, and incubated at room temperature for 1 hour. Materials that did not dissolve were removed by centrifugation. The clear supernatant was filtered, then loaded onto a Ni 2 -NTA agarose column pre-equilibrated in 8.0 M urea in Lysis Buffer. The column was washed with 250 ml (50 bed volumes) of lysis buffer containing 8 M urea, mM PMSF and 0.1 2-mercaptoethanol, and developed with sequential steps of lysis buffer containing 8M urea, 1 mM PMSF, 0.1 2-mercaptoethanol and 20, 100, 200, and 500 mM imidazole in succession. Fractions were monitored by absorbance at OD 2 8 0 nm, and peak fractions were analyzed by SDS-PAGE. Fractions containing the recombinant protein eluted at 100 mM imidazole.
Recombinant proteins 29479681 (SEQ ID NO: 677), 978477 (SEQ ID NO: 880), 26380318 (SEQ ID NO: 658) The pellet containing the inclusion bodies was solubilized in buffer B containing 8 M urea, 1 mM PMSF and 0.1 2-mercaptoethanol, and incubated for 1 hour at room temperature. Insoluble materials were removed by centrifugation at 20,000 x g for 30 min, and the cleared supernatant was loaded onto a 15 ml 1.6 x 7.5 cm) SP-Sepharose column pre-equilibrated in buffer B, 6 M urea, 1 mM PMSF, 0.1 2-mercaptoethanol. After washing the column with 10 bed volumes, the column was developed with a linear gradient from 0 to 500 mM NaCl.
Dialysis and concentration of protein samples Urea was removed slowly from the protein samples by dialysis against Trisbuffered saline (TBS; 10 mM Tris pH 8.0, 150 mM NaCl) containing 0.5 deoxycholate (DOC) with sequential reduction in urea concentration as follows; 6M, 4M, 3M, 2M, IM, M and finally TBS without any urea. Each dialysis step was conducted for a minimum of 4 hours at room temperature.
After dialysis, samples were concentrated by pressure filtration using Amicon stirred-cells. Protein concentrations were measured using the methods of Perkins (1986 Eur. J. Biochem. 157, 169-180), Bradford ((1976) Anal. Biochem. 72, 248-254) and Lowry ((1951) J. Biol. Chem. 193, pages 265-275).
The recombinant proteins purified by the methods described above are summarized in Table 5 below.
SUBSTITUTE SHEET (RULE 26) TABLE IBacterial cell Final Homolog Gene fraction used to Relative MW concentration J99 Sequence Identified symbol of purify recombinant Method of on SDS-PAGE of purified Composition Identifier j by Blast Homolog proteins purification gel protein of buffer Outer Membrane Proteins 16225006 P28635 YEAC Inclusion bodies His-Tag 18 kDa 5 mg/mI B (SEQ ID NO: 465) 26054702 P15929 figil Inclusion bodies His-Tag 37 kDa 1.18 mg/mI B (SEQ ID NO: 649) as dry pellet 7116626 P26093 e(P4) Soluble fraction His-Tag 29 kDa 0.8 mg/mI A (SEQ ID NO: 865) mg/mI C 29479681 P 13036 fecA Inclusions bodies SP-Sepharose 23 kDa 2.36 mg/mI B (SEQ ID NO: 677) 0.5 mg/mI B as dry pellet 14640637 P16665 TPFI Soluble fraction His-Tag 17 kDa 2.4 mg/mI A (SEQ I D NO: gel filtration SIN0 HR TABLE 5 (continued) Periplasmic/Secreted Protein 10032 P23847 dppA Inclusion bodies His-Tag I I kDa 2.88 mg/mI B (SEQ ID NO: 685) 4721061 P36175 GCP Inclusion bodies His-Tag 38 kDa 2.8 mg/mI B (SEQ ID NO: 812) Other Surface Proteins 4821082 P08089 M protein Inclusion bodies His-Tag 20 kDa 1. 16 mg/mI B (SEQ ID 978477 L28919 FBP54 Inclusion bodies SP-Sepharose 44 kDa 2.56 mg/mI B (SEQ ID NO: 880) 0.3 mg/mI B Inner Membrane Proteins 26380318 P15933 fliG Inclusion bodies SP-Sepharose 11 kDa 22 mg/mI B (SEQ ID NO: 658) Control Proteins with His-Tag P00722 IacZ Soluble fraction His-Tag 116 kDa 10 mg/mi A filtration S200 ppiB] Soluble fraction His-Tag 21 kDa 4.4 mg/mi A ~gel filtration S100 HR Buffer compositions: A=O m0rM Hepes pH 7.5, 150 mM NaCI, 0. 1 rnM EGTA B= 10 mnM Tris pH 8.0,1I0O mM NaCI, 0.5 DOC C= 10mrM MOPS pH 6.5,300mrM NaCI, 0.1 WO 96/40893 PCT/US96/09122 -102- IV. Analysis of H pylori proteins as Vaccine candidates To investigate the immunomodulatory effect of H pylori proteins, a mouse/H.
pylori model was used. This model mimics the human H pylori infection in many respects. The focus is on the effect of oral immunization in H pylori infected animals in order to test the concept of therapeutic oral immunotherapy.
Animals Female SPF BALB/c mice were purchased from Bomholt Breeding center (Denmark). They were kept in ordinary makrolon cages with free supply of water and food.
The animals were 4-6 weeks old at arrival.
Infection After a minimum of one week of acclimatization, the animals were infected with a type 2 strain (VacA negative) of H pylori (strain 244, originally isolated from an ulcer patient). In our hands, this strain has earlier proven to be a good colonizer of the mouse stomach. The bacteria were grown overnight in Brucella broth supplemented with 10 fetal calf serum, at 37 0 C in a microaerophilic atmosphere (10% CO 2 5%02). The animals were given an oral dose of omeprazole (400 .tmol/kg) and 3-5 h after this an oral inoculation of H pylori in broth (approximately 10 8 cfu/animal). Positive take of the infection was checked in some animals 2-3 weeks after the inoculation.
Antigens Recombinant H. pylori antigens were chosen based on their association with externally exposed H. pylori cell membrane. These antigens were selected from the following groups: Outer Membrane Proteins; Periplastic/Secreted proteins; Outer Surface proteins; and Inner Membrane proteins. All recombinant proteins were constructed with a hexa-HIS tag for purification reasons and the non-Helicobacter pylori control protein (p-galactosidase from E. coli; LacZ), was constructed in the same way.
All antigens were given in a soluble form, i.e. dissolved in either a HEPES buffer or in a buffer containing 0.5% Deoxycholate (DOC).
The antigens are listed in Table 6 below.
Table 6 Helicobacter pylori proteins Outer membrane Proteins SEQ ID NO:447 SEQ ID NO:677 SEQ ID NO:865 SEQ ID NO:812 SEQ ID NO:465 SUBSTITUTE SHEET (RULE 26) WO 96/40893 PCT/US96/09122 -103- Periplastic/Secreted proteins SEQ ID NO:685 Other cell envelope proteins SEQ ID NO:820 SEQ ID NO:880 Flagella-associated proteins SEQ ID NO:658 Control proteins P-galactosidase (LacZ) Immunizations Ten animals in each group were immunized 4 times over a 34 day period (day 1, and 35). Purified antigens in solution or suspension were given at a dose of 100 pg/mouse. As an adjuvant, the animals were also given 10 gg/mouse of Cholera toxin (CT) with each immunization. Omeprazole (400 gmol/kg) was given orally to the animals 3-5 h prior to immunization as a way of protecting the antigens from acid degradation. Infected control animals received HEPES buffer CT or DOC buffer CT. Animals were sacrificed 2-4 weeks after final immunization. A general outline of the study is shown in Table 7 below.
Table 7 Study outline, therapeutic immunization: Mice were all infected with H. pylori strain Ah244 at day 30. Proteins are listed by their SeqID Substance Mouse strain n=l0 Dates for dosing Dose/mouse 1. Controls, PBS 2. Cholera toxin, 10 pg 3. Protein 447, 100 pg CT 10 pg 4. Protein 465, 100 gg CT 10 pg Protein 649, 100 pg CT 10 pg 6. Protein 658, 100 pg CT 10 pg 7. Protein 677, 100 pg CT 10 pg 8. Protein 685, 100 pg CT 10 pg 9. Protein 812, 100 pg CT 10 pg Protein 820, 100 pg CT 10 pg 11. Protein 880, 100 pg CT 10 pg 12. Protein 865, 100 pg CT 10 pg Balb/c Balb/c Balb/c Balb/c Balb/c Balb/c Balb/c Balb/c Balb/c Balb/c Balb/c Balb/c 0,3 ml 0,3 ml 0,3 ml 0,3 ml 0,3 ml 0,3 ml 0,3 ml 0,3 ml 0,3 ml 0,3 ml 0,3 ml 0,3 ml 0, 14, 24, 34 0, 14, 24, 34 0, 14, 24, 34 0, 14, 24, 34 0, 14, 24, 34 0, 14, 24, 34 0, 14, 24, 34 0, 14,24,34 0, 14, 24, 34 0, 14, 24, 34 0, 14, 24, 34 0, 14, 24, 34 SUBSTITUTE SHEET (RULE 26) WO 96/40893 PCT/US96/09122 -104- Analysis of infection Mucosal infection: The mice were sacrificed by CO 2 and cervical dislocation. The abdomen was opened and the stomach removed. After cutting the stomach along the greater curvature, it was rinsed in saline. The mucosa from the antrum and corpus of an area of 25mm was scraped separately with a surgical scalpel. The mucosa scraping was suspended in Brucella broth and plated onto Blood Skirrow selective plates. The plates were incubated under microaerophilic conditions for 3-5 days and the number of colonies was counted. The identity of H. pylori was ascertained by urease and catalase test and by direct microscopy or Gram staining.
The urease test was performed essentially as follows. The reagent, Urea Agar Base Concentrate, was purchased from DIFCO Laboratories, Detroit, MI (Catalog 0284-61-3).
Urea agar base concentrate was diluted 1:10 with water. 1 ml of if the diluted concentrate was mixed with 100-200 tl of actively growing H. pylori cells. Color change to magenta indicated that cells were urease positive.
The catalase test was performed essentially as follows. The reagent, Tetramethyl-p-Phenylenediamine, was purchased from Sigma, St. Louis, MO (Catalog T3134). A solution of the regent w/v in water) was prepared. H. pylori cells were swabbed onto Whatman filter paper and overlaid with the 1% solution. Color change to dark blue indicated that the cells were catalase positive.
Serum antibodies: From all mice serum was prepared from blood drawn by heart puncture. Serum antibodies were identified by regular ELISA techniques, where the specific antigens of Helicobacter pylori were plated.
Mucosal antibodies: Gentle scrapings of a defined part of the corpus and of 4 cm of duodenum were performed in 50% of the mice in order to detect the presence of antibodies in the mucous. The antibody titers were determined by regular ELISA technique as for serum antibodies.
Statistical analysis: Wilcoxon-Mann-Whitney sign rank test was used for determination of significant effects of the antigens on Helicobacter pylori colonization.
P<0.05 was considered significant. Because the antrum is the major colonization site for Helicobacter most emphasis was put upon changes in the antral colonization.
Results Antibodies in sera: All antigens tested given together with CT gave rise to a measurable specific titer in serum. The highest responses were seen with SEQ ID NOs:865, 812, 658, 447, and 820 (see Figure 1).
Antibodies in mucus: In the mucus scrapings, specific antibodies against all antigens tested were seen. By far the strongest response was seen with SEQ ID NOs:685, followed by 447, 865, and 658 (see Figure 2).
SUBSTITUTE SHEET (RULE 26) WO 96/40893 PCT/US96/09122 -105- Therapeutic immunization effects: All control animals (BALB/c mice) were well colonized with H pylori (strain AH244) in both antrum and corpus of the stomach. Of the antigens tested 3 proteins (SEQ ID NOs: 812, 820, and 447) gave a good and significant reduction and/or eradication of the H. pylori infection. The degree of colonization of the antrum was lower following immunization with SEQ ID NOs: 880, 658, and 865 compared to control. The effect of SEQ ID NOs:465, 677, and 685 did not differ from control. The control protein lacZ, i.e.
the non-H pylori protein, had no eradication effect and in fact had higher Helicobacter colonization compared to the HEPES CT control. All data are shown in Figures 3 and 4 for proteins dissolved in HEPES and DOC respectively. Data is shown as geometric mean values. n=8-10 Wilcoxon-Mann-Whitney sign rank test p<0.05; x/10 number of mice showing eradication of H. pylori over the total number of mice examined.
The data presented indicate that all of the H. pylori associated proteins included in this study, when used as oral immunogens in conjunction with the oral adjuvant CT, resulted in stimulation of an immune response as measured by specific serum and mucosal antibodies. A majority of the proteins led to a reduction, and in some cases complete clearance of the colonization of H. pylori in this animal model. It should be noted that the reduction or clearance was due to heterologous protection rather than homologous protection (the polypeptides were based on the H. pylori J99 strain sequence and used in the therapeutic immunization studies against a different (AH244) challenge strain), indicating the vaccine potential against a wide variety of H. pylori strains.
The highest colonization in the antrum was seen in animals treated with the non- Helicobacter protein LacZ, indicating that the effects seen with the Helicobacter pylori antigens were specific.
Taken together these data strongly support the use of these H. pylori proteins in a pharmaceutical formulation for the use in humans to treat and/or prevent H. pylori infections.
V. Sequence Variance Analysis of genes in Helicobacter pylori strains Four genes were cloned and sequenced from several strains of H pylori to compare the DNA and deduced amino acid sequences. This information was used to determine the sequence variation between the H. pylori strain, J99, and other H. pylori strains isolated from human patients.
Preparation of Chromosomal DNA.
Cultures of H. pylori strains (as listed in Table 10) were grown in BLBB (1% Tryptone, 1% Peptamin 0.1% Glucose, 0.2% Yeast Extract 0.5% Sodium Chloride, Fetal Bovine Serum) to an OD 600 of 0.2. Cells were centrifuged in a Sorvall RC-3B at 3500 x g at 4 0 C for 15 minutes and the pellet resuspended in 0.95 mis of 10 mM Tris-HC1, SUBSTITUTE SHEET (RULE 26) WO 96/40893 PCT/US96/09122 -106- 0.1 mM EDTA Lysozyme was added to a final concentration of Img/ml along with, SDS to 1% and RNAse A Tl to 0.5mg/ml and 5 units/ml respectively, and incubated at 37°C for one hour. Proteinase K was then added to a final concentration of 0.4mg/ml and the sample was incubated at 55 C for more than one hour. NaCI was added to the sample to a concentration of 0.65 M, mixed carefully, and 0.15 ml of 10% CTAB in 0.7M NaCL (final is 1% CTAB/70mM NaCL) was added followed by incubation at 65 0 C for minutes. At this point, the samples were extracted with chloroform:isoamyl alcohol, extracted with phenol, and extracted again with chloroform:isoamyl alcohol. DNA was precipitated with either EtOH (1.5 x volumes) or isopropanol (0.6 x volumes) at -70 0 C for 10minutes, washed in 70% EtOH and resuspended in TE.
PCR Amplification and cloning.
Genomic DNA prepared from twelve strains of Helicobacter pylori was used as the source of template DNA for PCR amplification reactions (Current Protocols in Molecular Biology, John Wiley and Sons, Inc., F. Ausubel et al., editors, 1994). To amplify a DNA sequence containing an H. pylori ORF, genomic DNA (10 nanograms) was introduced into a reaction vial containing 2 mM MgC1 2 1 micromolar synthetic oligonucleotide primers (forward and reverse primers, see Table 8) complementary to and flanking a defined H.
pylori ORF, 0.2 mM of each deoxynucleotide triphosphate; dATP, dGTP, dCTP, dTTP and 0.5 units of heat stable DNA polymerase (Amplitaq, Roche Molecular Systems, Inc., Branchburg, NJ, USA) in a final volume of 20 microliters in duplicate reactions.
Table 8 Oligonucleotide primers used for PCR amplification of H pylori DNA sequences.
Outer membrane Proteins Forward primer 5' to 3' Reverse Primer 5' to 3' SEQ ID NO:649 5'-TTAACCATGGTGAAAAGC (for strains AH4, GATA-3' (SEQ ID NO:1919) TTAG-3' (SEQ ID NO:1920) AH61, 5294, 5640, AH18, and AH244) SEQ ID NO:649 5'-TTAACCATGGTGAAAAGC (for strains AH5, GATA-3' (SEQ ID NO:1921) ATC-3' (SEQ ID NO:1922) 5155, 7958, AH24, and J99) SEQ ID NO:865 5'-ATATCCATGGTGAGTTTGA TGA-3' (SEQ ID NO:1923) GCCA-3' (SEQ ID NO:1924) SEQ ID NO:677 5'-AATTCCATGGCTATCCAAA TCCG-3' (SEQ ID NO: 1925) GTATT-3' (SEQ ID NO: 1926) SEQ ID NO:764 5'-GATACCATGGAATTTATGA AAAAG-3' (SEQ ID NO:1927) TATAC-3' (SEQ ID NO: 1928) SUBSTITUTE SHEET (RULE 26) WO 96/40893 PCT/US96/09122 -107- The following thermal cycling conditions were used to obtain amplified DNA products for each ORF using a Perkin Elmer Cetus/ GeneAmp PCR System 9600 thermal cycler: Sequences (by SEQ ID NO:) 865 and 764; Denaturation at 94 0 C for 2 min, 2 cycles at 94°C for 15 sec, 30 0 C for 15 sec and 72°C for 1.5 min 23 cycles at 94°C for 15 sec, 55 0 C for 15 sec and 72 0 C for 1.5 min Reactions were concluded at 72 0 C for 6 minutes.
Sequence (by SEQ ID NO:) 649 for strains AH5, 5155, 7958, AH24,and J99; Denaturation at 94 0 C for 2 min, 2 cycles at 94°C for 15 sec, 30 0 C for 15 sec and 72 0 C for 1.5 min cycles at 94°C for 15 sec, 55 0 C for 15 sec and 72 0 C for 1.5 min Reaction was concluded at 72 0 C for 6 minutes.
Sequences (by SEQ ID NO:) 677 and 649 for strains AH4, AH15, AH61, 5294, 5640, AH18, and Hp244; Denaturation at 94 0 C for 2 min, 2 cycles at 94 0 C for 15 sec, 30 0 C for 20 sec and 72 0 C for 2 min cycles at 94 0 C for 15 sec, 55 0 C for 20 sec and 72 0 C for 2 min Reactions were concluded at 72°C for 8 minutes.
Upon completion of thermal cycling reactions, each pair of samples were combined and used directly for cloning into the pCR cloning vector as described below.
Cloning ofH. pylori DNA sequences into the pCR TA cloning vector.
All amplified inserts were cloned into the pCR 2.1 (pCRII in the case ofH. pylori sequence 865) vector by the method described in the Original TA cloning kit (Invitrogen, San Diego, CA). Products of the ligation reaction were then used to transform the (INVaF' in the case of H. pylori sequence 865) strain of E. coli as described below.
Transformation of competent bacteria with recombinant plasmids Competent bacteria, E coli strain TOP1 OF' or E. coli strain INVaF' were transformed with recombinant pCR expression plasmids carrying the cloned H. pylori sequences according to standard methods (Current Protocols in Molecular Biology, John Wiley and Sons, Inc., F. Ausubel et al., editors, 1994). Briefly, 2 microliters of micromolar BME was added to each vial of 50 microliters of competent cells.
SUBSTITUTE SHEET (RULE 26) WO 96/40893 PCT/US96/09122 -108- Subsequently, 2 microliters of ligation reaction was mixed with the competent cells and incubated on ice for 30 minutes. The cells and ligation mixture were then subjected to a "heat shock" at 42 0 C for 30 seconds, and were subsequently placed on ice for an additional 2 minutes, after which, samples were incubated in 0.45 milliliters SOC medium yeast extract, 2.0 tryptone, 10 mM NaCl, 2.5 mM KCI, 10 mM MgC12, 10 mM MgSO4 and 20, mM glucose) at 37 0 C with shaking for 1 hour. Samples were then spread on LB agar plates containing 25 microgram/ml kanamycin sulfate or 100 micrograms/ml ampicillan for growth overnight. Transformed colonies of TOPI OF' or INVaF' were then picked and analyzed to evaluate cloned inserts as described below.
Identification of recombinant PCR plasmids carrying H. pylori sequences Individual TOP 10 OF' or INVaF' clones transformed with recombinant pCR-H.pylori ORFs were analyzed by PCR amplification of the cloned inserts using the same forward and reverse primers, specific for each H. pylori sequence, that were used in the original PCR amplification cloning reactions. Successful amplification verified the integration of the H. pylori sequences in the cloning vector (Current Protocols in Molecular Biology, John Wiley and Sons, Inc., F. Ausubel et al., editors, 1994).
Individual clones of recombinant pCR vectors carrying properly cloned H. pylori ORFs were picked for sequence analysis. Sequence analysis was performed on ABI Sequencers using standard protocols (Perkin Elmer) using vector-specific primers (as found in PCRII or pCR2.1, Invitrogen, San Diego, CA) and sequencing primers specific to the ORF as listed in Table 9 below.
SUBSTITUTE SHEET (RULE 26) WO 96/40893 WO 9640893PCT/US96/09122 -109- Table 9 Oligonucleo)tide primers used for sequencing of H pylori DNA sequences.
NO:649 SEQ D NO:865 SEQ ID NQ:677 SEQ ID NO:764 Forward primers 5' to 3' Reverse Primers 5' to 3' S'-CCCTTCATT[TAGAAATCG..3' 5'-CTTTGGGAAACGCATC..3' (SEQ ID NO: 1929) (SEQ ID NO: 1936) 3' (SEQ ID NO: 1930) 3'(SEQ ID NO: 1937) 5'-ATCAAGTTGCCTATGCTGA..3' 3' (SEQ ID NO: 193 1) (SEQ ID NO: 1938) AGT-3' (SEQ ID NO: 1932) TCG-3' (SEQ ID NO: 1933) AGT-3' (SEQ ID NO: 1934) GGT-3' (SEQ ID NO: 193 5'-TITGAACACrITGATTATG CGG-3' (SEQ ID NO: 1939) GTC-3' (SEQ ID NO: 194 1) AAG-3' (SEQ ID NO: 1940) TTC-3' (SEQ ID NO: 1942) 5'-CTTATGGGGGTAF1-GTCA..3' 5'-AGGTTGUTGCCTAAAGACT-3' (SEQ ID NO: 1943) (SEQ ID NO: 1945) 5'-AGCATGTGGGTATCCAGC..3' 5'-CTGCCTCCACCTTTGATC..3' (SEQ ID NO: 1944) (SEQ ID NO: 1946) 5'-ACCAATATCAATTGGCACT..3' 5'-CTTGCTTGTCATATCTAGC..3' (SEQ ID NO: 1947) (SEQ ID NO: 1949) 5'-ACTTGGAAAAGCTCTGCA..3' 5'-GTTGAAGTG1TGGTGCTA..3' (SEQ ID NO: 1948) (SEQ ID NO: 1950) TAG-3' (SEQ ID NO: 195 1) CAT-3' (SEQ ID NO: 1953) AAG-3' (SEQ ID NO: 1952) TTGTC-3' (SEQ ID NO: 1954) 5'-GTAAAACGACGGCCAG..3' 5'-CAGGAAACAGCTATGAC..3' (SEQ ID NO: 1955) -(SEQ ID NO: 1956) Vector Primers Results To establish the PCR error rate in these experiments, five individual clones of SEQ ID NO:649, prepared from five separate PCR reaction mixtures from H. pylori strain J99, were sequenced over a total length of 897 nucleotides for a cumulative total of 4485 bases of DNA sequence. DNA sequence for the five clones was compared to the DNA sequence of SEQ ID NO:649 obtained previously by a different method, random shotgun cloning and sequencing. The PCR error rate for the experiments described herein was determined to be 2 base changes out of 4485 bases, which is equivalent to an estimated error rate of less than or equal to 0.04%.
SUBSTITUTE SHEET (RULE 26) WO 96/40893 PCT/US96/09122 -110- DNA sequence analysis was performed on four different open reading frames identified as genes and amplified by PCR methods from a dozen different strains of the bacterium Helicobacter pylori. The deduced amino acid sequences of three of the four open reading frames that were selected for this study showed statistically significant BLAST homology to defined proteins present in other bacterial species. Those ORFs included: SEQ ID NO:649, homologous to the val A B genes encoding an ABC transporter in F. novicida; SEQ ID NO:865, homologous to lipoprotein e (P4) present in the outer membrane of H. influenzae; SEQ ID NO:677, homologous to fecA, an outer membrane receptor in iron (III) dicitrate transport in E. coli. SEQ ID NO:764 was identified as an unknown open reading frame, because it showed low homology with sequences in the public databases.
To assess the extent of conservation or variance in the ORFs across various strains of H. pylori, changes in DNA sequence and the deduced protein sequence were compared to the DNA and deduced protein sequences found in the J99 strain of H pylori (see Table 10 below). Results are presented as percent identity to the J99 strain of H pylori sequenced by random shotgun cloning. To control for any variations in the J99 sequence each of the four open reading frames were cloned and sequenced again from the J99 bacterial strain and that sequence information was compared to the sequence information that had been collected from inserts cloned by random shotgun sequencing of the J99 strain. The data demonstrate that there is variation in the DNA sequence ranging from as little as 0.12 difference (SEQ ID NO:764, J99 strain) to approximately 7% change (SEQ ID NO:649, strain AH5). The deduced protein sequences show either no variation (SEQ ID NO:764, strains AH18 and AH24) or up to as much as 7.66% amino acid changes (SEQ ID NO:649, Strain SUBSTITUTE SHEET (RULE 26) WO 96/40893 PCT/US96/09122 -111- Table Multiple Strain DNA Sequence analysis of H. pylori Vaccine Candidates J99 Seq. ID 649 649 865 865 677 677 764 764 Length of 248 a.a. 746 nt. 232 a.a. 696 nt. 182 a.a. 548 nt. 273 a.a. 819 nt.
Region Sequenced: Strain Tested AA Nuc. AA Nuc. AA Nuc. AA Nuc.
identity identity identity identity identity identity identity identity J99 100.00% 100.00% 100.00% 100.00% 100.00% 100.00% 99.63% 99.88% AH244 95.16% 95.04% n.d. n.d. 99.09% 96.71% 98.90% 96.45% AH4 95.97% 95.98% 97.84% 95.83% n.d. n.d. 97.80% 95.73% 92.34% 93.03% 98.28% 96.12% 98.91% 96.90% 98.53% 95.73% 95.16% 94.91% 97.41% 95.98% 99.82% 97.99% 99.63% 96.09% AH61 n.d. n.d. 97.84% 95.98% 99.27% 97.44% n.d. n.d.
5155 n.d. n.d. n.d. n.d. 99.45% 97.08% 98.53% 95.60% 5294 94.35% 94.37% 98.28% 95.40% 99.64% 97.26% 97.07% 95.48% 7958 94.35% 94.10% 97.84% 95.40% n.d. n.d. 99.63% 96.46% 5640 95.16% 94.37% 97.41% 95.69% 99.09% 97.63% 98.53% 95.48% AH18 n.d. n.d. 98.71% 95.69% 99.64% 97.44% 100.00% 95.97% AH24 94.75% 95.04% 97.84% 95.40% 99.27% 96.71% 100.00% 96.46% n.d. not done VI. Experimental Knock-Out Protocol for the Determination of Essential H. pvlori Genes as Potential Therapeutic Targets Therapeutic targets are chosen from genes whose protein products appear to play key roles in essential cell pathways such as cell envelope synthesis, DNA synthesis, transcription, translation, regulation and colonization/virulence.
The protocol for the deletion of portions of H. pylori genes/ORFs and the insertional mutagenesis of a kanamycin-resistance cassette in order to identify genes which are essential to the cell is modified from previously published methods (Labigne-Roussel et al., 1988, J. Bacteriology 170, pp. 1704-1708; Cover et al.,1994, J. Biological Chemistry 269, pp. 10566-10573; Reyrat et al., 1995, Proc. Natl. Acad. Sci. 92, pp 8768-8772). The result is a gene "knock-out." Identification and Cloning of H. pylori Gene Sequences The sequences of the genes or ORFs (open reading frames) selected as knock-out targets are identified from the H pylori genomic sequence and used to design primers to specifically amplify the genes/ORFs. All synthetic oligonucleotide primers are designed with the aid of the OLIGO program (National Biosciences, Inc., Plymouth, MN 55447, USA), and can be purchased from Gibco/BRL Life Technologies (Gaithersburg, MD, USA). If the ORF is smaller than 800 to 1000 base pairs, flanking primers are chosen outside of the open reading frame.
SUBSTITUTE SHEET (RULE 26) WO 96/40893 PCT/US96/09122 -112- Genomic DNA prepared from the Helicobacter pylori HpJ99 strain (ATCC 55679) is used as the source of template DNA for amplification of the ORFs by PCR (polymerase chain reaction) (Current Protocols in Molecular Biology, John Wiley and Sons, Inc., F.
Ausubel et al., editors, 1994). For the preparation of genomic DNA from H. pylori, see Example I. PCR amplification is carried out by introducing 10 nanograms of genomic HpJ99 DNA into a reaction vial containing 10 mM Tris pH 8.3, 50 mM KC1. 2 mM MgCl 2 2 microMolar synthetic oligonucleotide primers (forward=F1 and reverse=R1), 0.2 mM of each deoxynucleotide triphosphate (dATP,dGTP, dCTP, dTTP), and 1.25 units of heat stable DNA polymerase (Amplitaq, Roche Molecular Systems, Inc., Branchburg, NJ, USA) in a final volume of 40 microliters. The PCR is carried out with Perkin Elmer Cetus/GeneAmp PCR System 9600 thermal cyclers.
Upon completion of thermal cycling reactions, each sample of amplified DNA is visualized on a 2% TAE agarose gel stained with Ethidium Bromide (Current Protocols in Molecular Biology, John Wiley and Sons, Inc., F. Ausubel et al., editors, 1994) to determine that a single product of the expected size had resulted from the reaction.
Amplified DNA is then washed and purified using the Qiaquick Spin PCR purification kit (Qiagen, Gaithersburg, MD, USA).
PCR products are cloned into the pT7Blue T-Vector (catalog#69820-1, Novagen, Inc., Madison, WI, USA) using the TA cloning strategy (Current Protocols in Molecular Biology, John Wiley and Sons, Inc., F. Ausubel et al., editors, 1994). The ligation of the PCR product into the vector is accomplished by mixing a 6 fold molar excess of the PCR product, 10 ng of pT7Blue-T vector (Novagen), 1 microliter of T4 DNA Ligase Buffer (New England Biolabs, Beverly, MA, USA), and 200 units of T4 DNA Ligase (New England Biolabs) into a final reaction volume of 10 microliters. Ligation is allowed to proceed for 16 hours at 16 0
C.
Ligation products are electroporated (Current Protocols in Molecular Biology, John Wiley and Sons, Inc., F. Ausubel et al., editors, 1994) into electroporation-competent XL-1 Blue or DH5-a E.coli cells (Clontech Lab., Inc. Palo Alto, CA, USA). Briefly, 1 microliter of ligation reaction is mixed with 40 microliters of electrocompetent cells and subjected to a high voltage pulse (25 microFarads, 2.5 kV, 200 ohms) after which the samples are incubated in 0.45 ml SOC medium yeast extract, 2% tryptone, 10 mM NaC1, 2.5 mM KCI, 10 mM MgCl 2 10 mM MgSO 4 and 20 mM glucose) at 37°C with shaking for 1 hour.
Samples are then spread onto LB (10 g/l bacto tryptone, 5 g/1 bacto yeast extract, 10 g/1 sodium chloride) plates containing 100 microgram/ml of Ampicillin, 0.3% X-gal, and 100 microgram/ml IPTG. These plates are incubated overnight at 37 0 C. Ampicillin-resistant colonies with white color are selected, grown in 5 ml of liquid LB containing 100 microgram/ml of Ampicillin, and plasmid DNA is isolated using the Qiagen miniprep protocol (Qiagen, Gaithersburg, MD, USA).
SUBSTITUTE SHEET (RULE 26) WO 96/40893 PCT/US96/09122 -113- To verify that the correct H.pylori DNA inserts had been cloned, these pT7Blue plasmid DNAs are used as templates for PCR amplification of the cloned inserts, using the same forward and reverse primers used for the initial amplification of the J99 Hpylori sequence. Recognition of the primers and a PCR product of the correct size as visualized on a 2% TAE, ethidium bromide stained agarose gel are confirmation that the correct inserts had been cloned. Two to six such verified clones are obtained for each knock-out target, and frozen at -70 0 C for storage. To minimize errors due to PCR, plasmid DNA from these verified clones are pooled, and used in subsequent cloning steps.
The sequences of the genes/ORFs are again used to design a second pair of primers which flank the region of H. pylori DNA to be either interrupted or deleted (up to 250 basepairs) within the ORFs but are oriented away from each other. The pool of circular plasmid DNAs of the previously isolated clones are used as templates for this round of PCR. Since the orientation of amplification of this pair of deletion primers is away from each other, the portion of the ORF between the primers is not included in the resultant PCR product. The PCR product is a linear piece of DNA with H. pylori DNA at each end and the pT7Blue vector backbone between them which, in essence, resultes in the deletion of a portion of the ORFs. The PCR product is visualized on a 1% TAE, ethidium bromide stained agarose gel to confirm that only a single product of the correct size has been amplified.
A Kanamycin-resistance cassette (Labigne-Roussel et al., 1988 J. Bacteriology 170, 1704-1708) is ligated to this PCR product by the TA cloning method used previously (Current Protocols in Molecular Biology, John Wiley and Sons, Inc., F. Ausubel et al., editors, 1994). The Kanamycin cassette containing a Campylobacter kanamycin resistance gene is obtained by carrying out an EcoRI digestion of the recombinant plasmid pCTB8:kan (Cover et al.,1994, J. Biological Chemistry 269, pp. 10566-10573). The proper fragment (1.4 kb) is isolated on a 1% TAE gel, and isolated using the QIAquick gel extraction kit (Qiagen, Gaithersburg, MD, USA). The fragment is end repaired using the Klenow fill-in protocol, which involved mixing 4ug of the DNA fragment, 1 microliter of dATP,dGTP, dCTP, dTTP at 0.5 mM, 2 microliter of Klenow Buffer (New England Biolabs) and 5 units of Klenow DNA Polymerase I Large (Klenow) Fragment (New England Biolabs) into a 20 microliter reaction, incubating at 30 0 C for 15 min, and inactivating the enzyme by heating to 75 0 C for 10 minutes. This blunt-ended Kanamycin cassette is then purified through a Qiaquick column (Qiagen, Gaithersburg, MD, USA) to eliminate nucleotides. The overhang is then generated by mixing 5 micrograms of the blunt-ended kanamycin cassette, 10 mM Tris pH 8.3, 50 mM KC1, 2 mM MgCl 2 5 units of DNA Polymerase (Amplitaq, Roche Molecular Systems, Inc., Branchburg, NJ, USA), microliters of 5 mM dTTP, in a 100 microliter reaction and incubating the reaction for 2 hours at 37 0 C. The "Kan-T" cassette is purified using a QIAquick column (Qiagen, Gaithersburg, MD, USA). The PCR product of the deletion primers (F2 and R2) is ligated SUBSTITUTE SHEET (RULE 26) WO 96/40893 PCT/US96/09122 -114to the Kan-T cassette by mixing 10 to 25 ng of deletion primer PCR product, 50 75 ng Kan-T cassette DNA, 1 microliter 10x T4 DNA Ligase reaction mixture, 0.5 microliter T4 DNA Ligase (New England Biolabs, Beverly, MA, USA) in a 10 microliter reaction and incubating for 16 hours at 16°C.
The ligation products are transformed into XL-1 Blue or DH5-a E.coli cells by electroporation as described previously. After recovery in SOC, cells are plated onto LB plates containing 100 microgram/ml Ampicillin and grown overnight at 37 0 C. These plates are then replica plated onto plates containing 25 microgram/ml Kanamycin and allowed to grow overnight. Resultant colonies have both the Ampicillin resistance gene present in the pT7Blue vector, and the newly introduced Kanamycin resistance gene. Colonies are picked into LB containing 25 microgram/ml Kanamycin and plasmid DNA is isolated from the cultured cells using the Qiagen miniprep protocol (Qiagen, Gaithersburg, MD, USA).
Several tests by PCR amplification are conducted on these plasmids to verify that the Kanamycin is inserted in the H. pylori gene/ORF, and to determine the orientation of the insertion of the Kanamycin-resistance gene relative to the H. pylori gene/ORF. To verify that the Kanamycin cassette is inserted into the H. pylori sequence, the plasmid DNAs are used as templates for PCR amplification with the set of primers originally used to clone the H. pylori gene/ORFs. The correct PCR product is the size of the deleted gene/ORF but increased in size by the addition of a 1.4 kilobase Kanamycin cassette. To avoid potential polar effects of the kanamycin resistance cassette on H pylori gene expression, the orientation of the Kanamycin resistance gene with respect to the knock-out gene/ORF is determined and both orientations are eventually used in H. pylori transformations (see below). To determine the orientation of insertion of the kanamycin resistance gene, primers are designed from the ends of the kanamycin resistance gene ("Kan-1" 5'-ATCTTACCTATCACCTCAAAT-3', and "Kan-2" AGACAGCAACATCTTTGTGAA-3'). By using each of the cloning primers in conjunction with each of the Kan primers (4 combinations of primers), the orientation of the Kanamycin cassette relative to the H.pylori sequence is determined. Positive clones are classified as either in the orientation (the same direction of transcription is present for both the H. pylori gene and the Kanamycin resistance gene), or in the orientation (the direction of transcription for the H.pylori gene is opposite to that of the Kanamycin resistance gene). Clones which share the same orientation (A or B) are pooled for subsequent experiments and independently transformed into H. pylori.
Transformation of Plasmid DNA into H. pylori cells Two strains of H. pylori are used for transformation: ATCC 55679, the clinical isolate which provided the DNA from which the H. pylori sequence database is obtained, and AH244, an isolate which had been passaged in, and has the ability to colonize the mouse stomach. Cells for transformation are grown at 37 0 C, 10% CO2, 100% humidity, SUBSTITUTE SHEET (RULE 26) WO 96/40893 PCTIUS96/09122 -115either on Sheep-Blood agar plates or in Brucella Broth liquid. Cells are grown to exponential phase, and examined microscopically to determine that the cells are "healthy" (actively moving cells) and not contaminated. If grown on plates, cells are harvested by scraping cells from the plate with a sterile loop, suspended in 1 ml of Brucella Broth, spun down (1 minute, top speed in eppendorf microfuge) and resuspended in 200 microliters Brucella Broth. If grown in Brucella Broth liquid, cells are centrifuged (15 minutes at 3000 rpm in a Beckman TJ6 centrifuge) and the cell pellet resuspended in 200 microliters of Brucella broth. An aliquot of cells is taken to determine the optical density at 600 nm, in order to calculate the concentration of cells. An aliquot (1 to 5 OD 60 0 units/25 microliter) of the resuspended cells is placed onto a prewarmed Sheep-Blood agar plate, and the plate is further incubated at 37°C, 6% CO 2 100% humidity for 4 hours. After this incubation, microliters of plasmid DNA (100 micrograms per microliter) is spotted onto these cells.
A positive control (plasmid DNA with the ribonuclease H gene disrupted by kanamycin resistance gene) and a negative control (no plasmid DNA) are done in parallel. The plates are returned to 37°C, 6% CO 2 for an additional 4 hours of incubation. Cells are then spread onto that plate using a swab wetted in Brucella broth, and grown for 20 hours at 37 0 C, 6% CO 2 Cells are then transferred to a Sheep-Blood agar plate containing micrograms/ml Kanamycin, and allowed to grow for 3 to 5 days at 37 0 C, 6% CO2, 100% humidity. If colonies appear, they are picked and regrown as patches on a fresh Sheep- Blood agar plate containing 25 micrograms/ml Kanamycin.
Three sets of PCR tests are done to verify that the colonies of transformants have arisen from homologous recombination at the proper chromosomal location. The template for PCR (DNA from the colony) is obtained by a rapid boiling DNA preparation method as follows. An aliquot of the colony (stab of the colony with a toothpick) is introduced into 100 microliters of 1% Triton X-100, 20 mM Tris, pH 8.5, and boiled for 6 minutes. An equal volume of phenol chloroform is added and vortexed. The mixture is microfuged for 5 minutes and the supernatant is used as DNA template for PCR with combinations of the following primers to verify homologous recombination at the proper chromosomal location.
TEST 1. PCR with cloning primers originally used to amplify the gene/ORF. A positive result of homologous recombination at the correct chromosomal location should show a single PCR product whose size is expected to be the size of the deleted gene/ORF but increased in size by the addition of a 1.4 kilobase Kanamycin cassette. A PCR product of just the size of the gene/ORF is proof that the gene had not been knocked out and that the transformant is not the result of homologous recombination at the correct chromosome location.
TEST 2. PCR with F3 (primer designed from sequences upstream of the gene/ORF and not present on the plasmid), and either primer Kan-1 or Kan-2 (primers designed from the ends of the kanamycin resistance gene), depending on whether the plasmid DNA used SUBSTITUTE SHEET (RULE 26) WO 96/40893 PCT/US96/09122 -116was of or orientation. Homologous recombination at the correct chromosomal location will result in a single PCR product of the expected size from the location of F3 to the insertion site of kanamycin resistance gene). No PCR product or PCR product(s) of incorrect size(s) will prove that the plasmid had not integrated at the correct site and that the gene had not been knocked out.
TEST 3. PCR with R3 (primer designed from sequences downstream of the gene/ORF and not present on the plasmid) and either primer Kan-1 or Kan-2, depending on whether the plasmid DNA used was of or orientation. Homologous recombination at the correct chromosomal location will result in a single PCR product of the expected size from the insertion site of kanamycin resistance gene to the downstream location of R3). Again, no PCR product or PCR product(s) of incorrect size(s) will prove that the plasmid had not integrated at the correct site and that the gene had not been knocked out.
Transformants showing positive results for all three tests above indicate that the gene is not essential for survival in vitro.
A negative result in any of the three above tests for each transformant indicates that the gene had not been disrupted, and that the gene is essential for survival in vitro.
In the event that no colonies result from two independent transformations while the positive control with the disrupted ribonuclease H plasmid DNA produces transformants, the plasmid DNA is further analyzed by PCR on DNA from transformant populations prior to plating for colony formation. This will verify that the plasmid can enter the cells and undergo homologous recombination at the correct site. Briefly, plasmid DNA is incubated according to the transformation protocol described above. DNA is extracted from the H.
pylori cells immediately after incubation with the plasmid DNAs and the DNA is used as template for the above TEST 2 and TEST 3. Positive results in TEST 2 and TEST 3 would verify that the plasmid DNA could enter the cells and undergo homologous recombination at the correct chromosomal location. If TEST 2 and TEST 3 are positive, then failure to obtain viable transformants indicates that the gene is essential, and cells suffering a disruption in that gene are incapable of colony formation VII. High-throughput drug screen assay Cloning, expression and protein purification Cloning, transformation, expression and purification of the H. pylori target gene and its protein product,e.g., an H. pylori enzyme, to be used in a high-throughput drug screen assay, is carried out essentially as described in Examples II and III above. Development and application of a screening assay for a particular H pylori gene product, peptidyl-propyl cis-trans isomerase, is described below as a specific example.
SUBSTITUTE SHEET (RULE 26) WO 96/40893 PCT/US96/09122 -117- Enzymatic Assay The assay is essentially as described by Fisher (Fischer, et.al. (1984) Biomed.
Biochim. Acta 43:1101-1111). The assay measures the cis-trans isomerization of the Ala- Pro bond in the test peptide N-succinyl-Ala-Ala-Pro-Phe-p-nitroanilide (Sigma S-7388, lot 84H5805). The assay is coupled with cc-chymotrypsin, where the ability of the protease to cleave the test peptide occurs only when the Ala-Pro bond is in trans. The conversion of the test peptide to the trans isomer in the assay is followed at 390 nm on a Beckman Model DU-650 spectophotometer. The data are collected every second with an average scanning of time of 0.5 second. Assays are carried out in 35 mM Hepes, pH 8.0, in a final volume of 400 ul, with 10 JM a-chymotrypsin (type 1-5 from bovine Pancreas, Sigma C-7762, lot 23H7020) and 10 nM PPIase. To initiate the reaction, 10 pl of the substrate 2 mM N-Succinyl-Ala-Ala-Pro-Phe-p-nitroanilide in DMSO) is added to 390 gl of reaction mixture at room temperature.
Enzymatic assay in crude bacterial extract.
A 50 ml culture of Helicobacterpylori (strain J99) in Brucella broth is harvested at mid-log phase (OD 600 nm 1) and resuspended in lysis buffer with the following protease inhibitors: 1 mM PMSF, and 10 pg/ml of each of aprotinin, leupeptin, pepstatine, TLCK, TPCK, and soybean trypsin inhibitor. The suspension is subjected to 3 cycles of freezethaw (15 minutes at -70 0 C, then 30 minutes at room temperature), followed by sonication (three 20 second bursts). The lysate is centrifuged (12,000 g x 30 minutes) and the supernatant is assayed for enzymatic activity as described above.
Many H. pylori enzymes can be expressed at high levels and in an active form in E.
coli. Such high yields of purified proteins provide for the design of various high throughput drug screening assays.
EQUIVALENTS
Those skilled in the art will recognize, or be able to ascertain using no more than routine experimentation, many equivalents to the specific embodiments and methods described herein. Such equivalents are intended to be encompassed by the scope of the following claims.
SUBSTITUTE SHEET (RULE 26) 118 SEQUENCE LISTING GENERAL INFORMATION:
APPLICANT:
NAME: Astra Aktiebolag STREET: S-151 CITY: Sodertalje
STATE:
COUNTRY: Sweden POSTAL CODE (ZIP): (ii) TITLE OF INVENTION: NUCLLIC ACID AND AMINO ACID SEQUENCES RELATING TO HELICOBACTER PYLORI FOR DIAGNOSTICS AND THERAPEUTICS (iii) NUMBER OF SEQUENCES: 1956 (iv) COMPUTER READABLE FORM: MEDIUM TYPE: 8-mm cartridge tape COMPUTER: SPARC station LX OPERATING SYSTEM: SunOS Release 4.1.3 SOFTWARE: tar CURRENT APPLICATION DATA: APPLICATION NUMBER: PCT/US96/09122 FILING DATE: June 6, 1996 (vi) PRIOR APPLICATION DATA: APPLICATION NUMBER: US 08/630,405 FILING DATE: 01-APR-1996 (vii) PRIOR APPLICATION DATA: APPLICATION NUMBER: US 08/561,469 FILING DATE: 17-NOV-1995 (viii) PRIOR APPLICATION DATA: APPLICATION NUMBER: US 08/487,032 FILING DATE: 07-JUNE-1995 (ix) CORRESPONDENCE ADDRESS: ADDRESSEE: LAHIVE COCKFIELD STREET: 60 State Street, Suite 510 CITY: Boston STATE: Massachusetts COUNTRY: USA ZIP: 02109-1875 ATTORNEY/AGENT INFORMATION: NAME: Mandragouras, Amy E.
REGISTRATION NUMBER: 36,207 REFERENCE/DOCKET NUMBER: GTN-001C5PC (xi) TELECOMMUNICATION INFORMATION: TELEPHONE: (617)227-7400 TELEFAX: (617)227-5941 AMENDED
SHEET
I PENIUG 10 31 "7 119 INFORMATION FOR SEQ ID NO:l: SEQUENCE CHARACTERISTICS: LENGTH: 1527 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .1527 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:l
ATGTGI'CTC
AATATCATCA
AATAAAGACC
AATTATGTCA
GGGATATTAT
TGTATTCTCA
GACCAAAAAG
GACAACCTAT
TTGTATCTCA
GATGTTAA
TCAAAATTAA
CAACAACTAC
GAAAA ITATT
GAAGAAAAAA
CTTATTTTG
AAGAATGCTA
TCAGGTCAAA
CATCAACAAA
GATAATCTT
CTAAAATCTT
GGAGCGCAAT
AGAGCC77IF1
CCCATI'ATGG
TTAATTATTA
CAAGGCAAAC
TGCGAATI'GT
AGGAAATT
CTCAGCTI'GC
ATACTATCAA
GTAATCTT
TTCCA?1'AG
ITTCCAACCA
AAAGCATGCA
TATTTAACTT
ATAATTTTGT
TCACCACTCT
TTGGTGTGGG
AAGATTI'ATC
TCTGTATTT
TCCATAGCAT
AA.AACTTTAA
GCGGAAAAAG
TTATCATTAA
TGAGTGCCAT
TT1ATGCAAAA
TTGATGAGAA
ATAATGGGGT
TAAAACCAAG
AAAAAGAGI!
CACACCGCAT
TAATAGAACA
TTI'TGAAACA
ATCAAGCT1'G
TAATAAACTC
GCTTAACACT
ITTCAATCTA
TATIWATCTA
TATAGCAAAA
AAATTACT'rA
CATGCTAAAT
GAAAGTAGCC
AAGTATTGCA
AGCAATI'GCT
AI'TI'ATGGA
AGATI'ACAA
TACATI'GAA
TCTCTCTITA
CACGCTGAT
TAACAAATAC
ATTTCAAGAT
CAATATCACT
TTTTCAAAAT
AGATI'TTTCT
TAATI'GCATI'
TrAGA'TT
GAATAGTGTC
GGGCAACTTT
ACAATAC
CAAACCATA
ACACAAGTI'A
ATCCATAACG
CAACGCATI'A
CCCTTTATAA
AAACATAGTG
TACTCTGGAC
'TI'CACCATA
CAAAAAAACT
CTATI'ITIC
GGGTATATCC
AAGTGGTT
ATACCGAAAC
AATATI'AGTT
CACTCTAATA
AATFI'ATTAT
CCATTACAAG
TTTCTC'Tr
AAAGAGCAAT
TGTCTTAATG
TTAGGTCAAA
GTTTTAGATG
ATTrAAAA
AAGCAAGCTA
GAAACCCTTA
TTGCCGAACA
AAAATCTAAA
GACTGCACAT
TAGGGCTI'AT
TGATrTI'PIGC
CTTCCATAGA
TAGATAACCA
AATTTATIGA
TAATATTI'AC
TAATGGTTT
AAGCATTTAG
TTGCTATCAA
CAGAAACACA
TCTCTTATCC
AAATTTATGC
TAGGTFITA
ACTTGGAACT
ATGCTGGGTA
TGAAGCAAAA
AI'GCAACAA
AGCAACGCAT
AGCCAAGCAG
AATCGCAATC
ATGAAAI'AT
TGAAAAAACA
ATI'TCTATA.
'TTFFTTGAG
CCGCCCCCTA
CAGTCTGTTT
AACAGTGCCT
TAAACTTCAA
AAAGAACAAG
AACAAAAGAA
CATATATGCT
TATTATCCTT
CTCTACCCAA
TAAATACT
AATCAAATTA
TAATTCAAAA
ATTAGTCGGC
TACCCCAAAT
AAATAGCTAC
TAGCATI'GAT
AAGAGAAATA
CACACTATT
AGCTACCATG
CGCCATCGAT
TAAGATGGCT
CGTGTTAGAT
GGGATTAI'T
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1140 1200 1260 1320 1380 1440 1500 1527 INFORMATION FOR SEQ ID NO:2: SEQUENCE CHARACTERISTICS: LENGTH: 399 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) 2 'ii) HYPOTHETICAL: NO ANTI-SENSE: NO IZ4F %0 W I P U8 DEC 3U 120 (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .399 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2
ATGGAGCGCA
AAAGGTAITC
ACAGGTTTAG
ACGGTAG'FTG
GGAGTGATCG
GCCATTCCAG
TATGTGCAGA
AGACGCTCCA
TAATGAATTG
TGGTG ITGAG AAATrTAGA
CACCCATTAT
CCTAI'ICTI'
TGCAAGTGGA
GAGCATTA
TGCAGGSCT
CAITATCTCT
AGCGTITAAC
TTCTAAGGCG
TT1ACTTGATC
TATI'TTGTCT
TG'rrTAATAA
TGGAAACACC
TCTACAGCCC
AATTGGGCG
CTTATCGCCA
TTAAAGCGCA
TCTAAAAAA
AAAAAGAAAT
AGGr'rCTITAA
CCTTTATTGG
CGTI'AGGTCA
CCGCTGCAGG
AGGTGTATGA
GATGAGACCA
GCAAAGCACG
AGCTTCTT
GAITTTTAGCA
TTTATCGGTT
INFORMATION FOR SEQ ID NO:3: SEQUENCE CHARACTERISTICS: LENGTH: 474 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .474 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:3
ATGCATGAAC
GAACTCAAAC
GAGGAACAAT
GATTCTCTAG
AATATGGATA
CTI'CTATTGA
GTGGGGGTAG
AGAAAAGAAG
GCATI'GAAAG
AAAGAAAGAC
TCCGTGGA.AG
CGATI'ATAAA
GCGGCATTGA
CGCCTGTAGT
GTAAATCAAT
TGGATAAGAA
AGGTATTRGA
AAAATrGATT
TGTAGGAAAA
ACGCATCAAT
TACAATAGGC
AGGTGAGTrI'
ATGGAGTT
TTACATCAA
AATAATGAAT
GAAGACATAG
AATATI'GAAC
AACCTI'GGTC
TATTAGT
GCGTrAATITG 'ITTGAT'rCAG
ATTTGCGAAA
GTAAAGAAAT
AACGGCGGTT
AACI'GAAGA
TTAATCCTAA
CAATAGGAGG
CAGGAGTGGG
ATI'ATAAAAA
AATTGTGCAG
'"ITFGCAAT
CAAAGAATGC
AAGAGTTAAA
TTCTAATTTT
TI'TGGTGTTG
'ITTAGCATTA
ATCCCAACAA
GATG
INFORMATION FOR SEQ ID NO:4: SEQUENCE CHARACTERISTICS: LENGTH: 336 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO ig4iENDEAD SH-EET PCT/US 96/09122 121 (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...336 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:4 ATGCCTGGCG TGTATCAAAT GAGTATAGAG CCTCTTTTAA AAGAATGCGA AGAATTAGTG GGTTTAGGCA TAAAAGCCGT TTTATTGTTT GGCATTCCTA AACATAAGGA CGCTACAGGA 120 AGCCATGCGT TAAATAAGGA TCACATTGTC GCAAAAGCTA CGAGAGAAAT TAAAAAACGA 180 TTTAAGGATT TGATCGTTAT AGCGGATTTG TGTTTTTGCG AATACACCGA CCATGGGCAT 240 TGCGGGATTT TAGAAAACGC TTCTGTGTCT AACGATAAAA CGCTAAAGAT TTTAAATCTT 300 CAAGGGCTTA TTTTGCTGAA AGCGGTGTGG ATATTC 336 INFORMATION FOR SEQ ID SEQUENCE CHARACTERISTICS: LENGTH: 195 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...195 (xi) SEQUENCE DESCRIPTION: SEQ ID GTGGAAAACA ACAAGAGTTT AAAGCATGCG AATGAGTTAA GGGATAAGCG AGATGAATTA GAGTTTCATT TGCGAGAGCT TTTCGGGGGG AATGTTTTTA AAAGCAGCAT TAAAACCCAT 120 TCGCTCACAG ATAAAGACTC AGCGGACTTT GATGAGAGCT ATAACCTTAA TATCGGGCAT 180 GGGYTCAATA TSATA 195 INFORMATION FOR SEQ ID NO:6: SEQUENCE CHARACTERISTICS: LENGTH: 1857 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: l(Ivuus 96/09122 IPEANS 1 ?_DC NAME/KEY: misc-feature LOCATION 1 1857 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:6
GTG'FFIGTGG
CAAAAGCGGC
CCCTITTA
ATTTATTC'
GCCTATGAAC
AAAGATTACA
TPI'AAGGGCG
ATGGCTAATG
TCCTATCTAG
TATITCTCTT
GATCTCATAG
'PTCAAATTTr
TATGGTCTIA
AG'TI'TATG
GAACCCGTI'A
ATTAGAGCCA
AAATACCACC
TGCGAATTTT
GACTTGTATC
CATGGAAAAA
GAATACCCCC
T FFATCTITA
TTCACCTCTA
TGCTTGAGCG
GTGCTGTITG
CTTAACGCTA
GCCAAACT
GCTGATTTCA
GGCAATAGCG
ATGCCCACTG
TCAGGTAAGA
CAAGCAAACA
AGITI'CAAAA
AAGTCTI'GTT1
CTATA'ITTAT
CTGTITTGAT
GGCTrATCA
TGAAAAACAA
ACATCCACI'
CGAATAACTA
TAGGCACAAT
AGTI'ACACGC
ATTTCACAC
TITTCTAA
ATATI'AGTT
TGAATAAAAA
AGCTTGAAAA
CCACTAGATT
ACAXTrTCT
TCAAGGAAAA
TCTTAAATGA
CTAAATCACA
TGCATGCTrTA
GAAGGATI'AT
AATTAGTGGG
CTGATAGC'Fr AAGGTTTIT1
GCTCTTTTAT
TAGCGATGAG
TGATGACGTT
ATTTTGGI'C
ACAGTGTTTA
AGCTGACGAA
AATAGAAGAA
TGATGGGGGG
ATTGITI'GTA
TGTAGCGATT
AAGAATGGAG
AGCGTTCATG
AAATCCAAAC
TGAATGTT
CAAATI'GGGG
TTCTXITTAT
TGTTAAAAAG
TGATTTCATG
?I'ATCTCACC
GCATTTTGCA
CTTCAAAGAT
AAAAGAATAC
TGTGGGAATG
AATGCATGGT
CGATTTGAGT
GAGCGATG
TTCGCCTAAA
TATI'AGTGGA
TAATGGTGAT
TGAAAAAATG
AGCCAACGCA
CACGCI'CCT
AGCGATGAGT
AAAAAGCGAG
AGCTTCAGCA
TGTCCATGAC
CAAAAAAAGC
CT1'AAAGCAG
AATAGGTTGT
ACAATI'GTAT
GTTATI'GTGC
CGAGCGATGA
AGCATTT
AGAGAAGACA
TTAGATGATG
GGCA?'GAT
AGCG'TrrA
AAAATCGTTA
CGAGCCTATA
ATAGAGCAAG
GACAATAATT
AGGATAGAGC
ACTAAAGATG
AATGAAGCCC
GGGGtGAAAG
GAAAAATATT
TTGATAAAA
AACTCACAAG
GGCTCCAAAG
ATTACGCTAG
AAACAAAGCG
GCGACTITCT
TTA TT
ITTTGATGGCA
ATCAATTCGC
GGACACACTT
TCTAAACGCT
TAGTI'ATAGA
ACATGCAAAA
TI'GGTrCCC
TATCTGTTAT
TI'GTAGCTCT
AATTTAAAAA
CCATGAAGCC
GGCTTGTGAG
GGGTGATCCT
T1'AACCAC
GGAATTI'GT
TTGATGAAAC
ATGAGAAGCA
A'TTATTAGA
TI'GAAGAG'rr
TCATAGAAGA
GCATTATTTA
CTITTATTTG
AAGTITATI'
TI'AGCGCTAT
TCAACGCTCT
TTr'rAAAGGA
AGCAAGGCAT
GCAG'ITATIGG
TTAAGGAATG
CTATGGAAAA
ATGTAACTTC
AAGAAGACAA
CTITrrATTr
TGATACTTGG
ATGGGGCAAT
GCAAGAGGTT
GGGTGTCAAT
TGAAACTTTT
TC2TT1CAA
TGGATTCAAG
ACCIr G
TAGTAAAGAA
CGCTGCAAAC
TACTAACAAC
TTCCAAAAAA
TACCCCTGAA
CAATAGGGAT
AAAGAGAGAA
CACTCTCAAT
TCAAAGGATI'
GCTACTGAGT
CTCCAAACAA
CAACAGAAAA
TGCCAATAAG
TGAGATCAGT
AGACAGCGAA
CAAACTAGCT
GACT'I"IGGGT
TAATTCTTTA
CGTCTCTAGT
TACTT'TTT
TAACAATTTr
TAACGCTTGG
GAACTTCCAC
CTCAACCGGT
T1'GCCTA 120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1140 1200 1260 1320 1380 1440 1500 1560 1620 1680 1740 1800 1857 INFORMATION FOR SEQ ID NO:7: SEQUENCE CHARACTERISTICS: LENGTH: 330 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1 .330 (xi) -SEQUENCE DESCRIPTION: SEQ ID NO:7 GTGAAAACAT CGTGTTI'GGT TACAATAGGG AGGATCCGGG CAGTTGTTGC TTCGTGAGGG AGGT TATG AAT =TACCG -GGCATGC ATTTGTATGT GCATAAGGGG CATACGGAAT 1/ ,AAAACTT TATCCATGAA A LTAGCGCAA GGGTTGCCTA
GCGTTTTTAT
CITATAACAC
TAGGCGAGGG
AAGAATGGAG
CATTAAGGCG
GAAGACGCCA
TGAAAGGCTG
GGTTTTCCCT
f'~c Ljy PCT/Us 9 6 /0912) IPEAJ3S 18 DEC1 AGCAATGAAT GGCCTAAGGA ATI"TAATAT TTAGC LTTAC CTTATGAAGT GFI'GCAAAA GAGCGCGGGA (;CTCTTGGGC GAAGCATITA INFORMATION FOR SEQ ID NO:8: SEQUENCE CHARACTERISTICS: LENGTH: 204 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .204 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:8 GTGGCTAAAG ACATCATCAG CGAGTCTCAA AACCTT1'GCG CAAGAAAATT CCGCCGTrG TATGCGTTAT TGAAAGAAAA TGAAATGCTC ATTCGCATCG GATCTTATCA AATGGGGAAC GATAAAGAGC TTGATGAAGC GATITAAGAAA AAGGCTCTAA TGGAGCAATI' ITI'AGTGCAA GATGAAAACG CT1'TACYAGC CTIT INFORMATION FOR SEQ ID NO:9: SEQUENCE CHARACTERISTICS: LENGTH: 1338 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .1338 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:9
ATGAAATCAC
GC TTI'AG
TTGATCAAGC
TATATITACA
AAACAGCCTG
AGCTIGTATG
TGCATGTTTT
GAATATI'TAA
V.AAGAGCTTG
GCCCAATCCT
AAACCATTTT
AGCTCAAGCC
TGGATTTTTC
GCGI'AAATA
AATI'GCTCCC
ATCAAATAGA
AAATCGCTAA
AATTGAAAAT
CGCACAAGCT
AGTGGAAAAC
TAAATACAAC
TATIGATrrC
TTTTGGCCCT
TTTGGTTCAA
GCGTTGTAAA
AGAATGTTTA
GGAGCGCCTT
TACGCGCTCC
GAGCAAGACG
ATTCTTTAA
CCTATCCCTT
TTI'ACGAGCG
AAGAAAAAT'
CCCCCATGCG
GAAATGAT'G
TCTAGTAACT
AAATGATGGT
C'TrGATTr
GAGACGATAA
TAATCACACG
GGGCTAAGGA
GCATCAAGGA
AGGATAAAAT
AAAATAAAGA
TGCGTITTTGA.
CAAACAGATC
GGAAAAITCT
AACTTACCCT
AAAAATCTTA
TATTTTGGAC
TAA.AAAGGCA
CACTAAAGAA
CAGGCTCATC
AGAAGCCTTA
120 180 240 300 360 420 480 540 1 UsIVJt f I
I
Uc.J 1336
ATTTIATAGGG
GCCAAACTCT
GTGAAAATGT
CTCAACGGGT
CATTTGCCI'
GAATI'GCAAG
AAGGGTGATA
CAAGAAAAA
GAGTGCGTGC
GTGGGGGGAA
CATCTAAAAG
GACTTFIGCTA
AACATCGCT
ATAGGAITGC
ACGATrTGGA
TCATGCGTGG
TTGACACTGA
TGATGCCTGA
AGTATCTC
AGCTCGCTT
CCTCTAATGA
CTI'ATAGGGT
TGGTCGTGTA
GCTCTAACGA
AAGAGCCACC
TAGAAA TIT
AAAAATCCAA
TA'TTGCT
GGGTAAAATC
TGA.AGCGATG
ACAAATCTTA
TCACCAATAT
AATAGAAATC
AGATCGGATC
AGAAATCTTT
TGAAAACAAT
ATATGATCAA
GCCTAATTTG
AAAAAGCAGC
AAAATCGCCC
TTTATGGTG
APITTCTTCAG
AAACAAGCCA
TTGAGCGCTT
TCTAAAAAA.A
GCTATGAAAA
TT'AGAAGAAG
GACACAAGCC
GCA'TrCAAA
ATGAGCGAAT
TGGGTGATAG
GGGAGTITI'G
CTTTCACTTG
GGAACAACAA
CGTITGAAAA
TTATCAATCA
GTTCTAATGA
TCGCTCTTAG
ACGCTCAAGA
CGCGATCGCT
ACCATTCAAA
AAGACTCTTA
TGCTCACCAG
ATGGAGGGAG
TAGAAGTGAT
CATGGA'IITA
GGCGGTGT'A
AATCC' ,CTCT
TI'ACCAATCG
AACGCTTAAA
CATTCCTAA
GATTrAGC C.ITCAArTrA
CAGCCAATGC
TCGGCGCTAC
AAGGGCT'TA
GGCGCAAT'A
CGCTAITTTCT
600 660 720 780 840 900 960 1020 1080 1140 1200 1260 1320 1338 AAAGAAAAAA GGGGATTC INFORMATION FOR SEQ ID NO:l0: SEQUENCE CHARACTERISTICS: LENGTH: 252 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .252 (xi) SEQUENCE DESCRIPTION: SEQ ID NO-.l0 GTGAGTT1TGG
TI'GAGCGAAA
TTCAATTCTA
TCTCAAGTCG
AGAGCGTTIGG
GGGCGTTTCA GGGGTATTAT GGAGGGCTAG TTTGGAGCGC GATCCCCATG C LTI"ITTAC ATIrTGGAT CATCTI'GTTT ITAGTCTI'GC TGCGCACGGA GITTrTAAAA GCAAGGAATA
GG
TGGATTI'AGT
TCATTGTGAT
TCTTI'AGCTG
TGGACTACAC
GGGGCAAAGG
TCTAGCGCG
GATGGGGCT'
CAAAGCCGCT
INFORMATION FOR SEQ ID NO:11: SEQUENCE CHARACTERISTICS: LENGTH: 120 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori I> x) FEATURE: NAME/KEY: misc-feature
PCTIUS
1PEMIUS 9 6 /0,q12 o nr \9 LOCATION .120 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:l1 ATGAGTGAAG CCTATI'TT1' ACACCATAAA AACGCTTCTC AAGTGTCTCT TAATGAACAA GTT=rAAACG ?TATGAAACA AGTI'CAATrG GATGAAAATT 'TI'GGAATGT '1TCTCTTATG INFORMATION FOR SEQ ID NO:12: SEQUENCE CHARACTERISTICS: LENGTH: 900 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .900 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:12
GTGATCCTGA
TCAAAAAGAA
TTTGTAGAAG
GGCATTA TI
GAAAATGAAG
AGCAAAAGCT
GTGGAAATGG
GATCCTAATG
AAAKATTTAA
11M GTGAA
ATCCACAGAG
GTTTTACTAG
TGCCATATGT
CATI'ATCA AA
AACGACCACA
TA r=rATCAT
AAAGCCAAAG
GGGCAAAAGC
TTGGGCATGC
CTGAAAGAAA
CTGGCTCTAT
AGTGGGGAGA
GCCT1'AAA
AGAGCATTTA
GGATCTGCCC
AGGTAGAGCG
ATGAGCTTT
GTI'CCACTT
AAAACCCTAA
AGCGTGGCTC
CGTGGTGGAA
CTCTGTGATC
GATTGAGGGG
GTTAAGCGGG
AGCGTI GAA
TAAAGCCGAA
AAAAGC?1'AT
CCCTGATGTG
CCCTATI'GAA
CAGTAAAGAT
TI'GAAAGAA
AAAAGAGTCT
ATGCCCTI'A
AGGCGAAAAG
GIT7I=CT
GATCAGAAAG
AT1'GAAGACG CT TrAAAAA
AATTTGCACT
AATTTAGTTT
CATGGCACAG
AAGATCCACA
ATCATCACAA
GAGCATTTGG
T'rATCCTTAA
AGGGTAAGTC
GAATACTTAG
GGGATTGATA
ATCGCTTCAA
AAAARGCGCT
GCA TFTCCC
TGTGCTI'CAG
AACATGGCT
TTGTCGTTAC
CTGAGATGTT
GCAGGATGGT
AACAAATCAA
ACGATAAAGA
ACATGTGCAT
CGCCACGACA
ATGGTCATGA
CGCATGCCAC
CCGGGAGYAT
AGATrCTTAA TI'CGTGGTT
TATCGCAGCG
CAAAGAGGAT
TAAGGATAAT
GCCGAI'CTA
TTTAATGGTG
AGCCCC1'I'FI GGAATrGTTr
AATCCACACT
GGAATGTGGG
ACGCATCGTC
TGAAGATCAG
TI'GCGCGGTG
CGCT1'TAAAT
ATCACATGCA
CAAAAACTCA
120 180 240 300 360 420 480 540 600 660 720 780 840 900 INFORMATION FOR SEQ ID NO:13: SEQUENCE CHARACTERISTICS: LENGTH: 642 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) M(ThECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori I P i 9 g1 126 (ix) FEATURE: NAME/KEY: misc-feature LOCATION .642 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:13
ATGAAAGAAA
ATCGTGGTGT
TTCAAGGGTC
TTTAAATCCA
CCCATTITGC
TTAAACAACG
AAACCCGCTT
CAGCCCAGAT
TI'GTTAGAGG
AAAGAAGAAT
TCAATTAA
AAAAC'TTTTG
TTTAGTGGT
ATAACGAAGT
AF1'ATCGTT
CCTATTITTTC
CTTTGA'ITTT
TAGATTICGCC
TATT1AGGAAC
GCGATAAAGT
TGATITTTGGA
AAAACGCTAA
GCCTTTIAGGA
GTI'TGCCCTA
GGA TIAAAC
TTCAGTGGGT
TAAAGGCACG
AGAAAAGTCC
AAATATI'CAA
GCTTGATI'GT
GGGGCGCTAT
GCAACTGCT'
AGCATTTTT
ATCATGAGCG
AAAAATI'CGC
rrl'AACGCCA
TTAAAGCCTC
CATGGGGATA
AACACGC'T1
GTGTATTTAG
AAAAACGCAT
AAGATCCT1TT
TTTTTAAGTA
AAATACAAAA
TGCTIATT
CTAAAA.ATGA
TGCT'rAAAAC
TTACCGAAAG
AAAAAATCCA
ATGCACAATI'
CGTTCTATCC
GCGAACCTT
TTAAATIrGT GCATGGC7IG
TA
TGGGCTTGGG
TTTAGTGTAT
TTATGAAAAC
CCCTAAAACC
AGAAAACCT
GCAACCGCTC
CAGCCAATCC
AAAA'FITGAT
TrTAAAAAT
TATGGGTATA
INFORMATION FOR SEQ ID NO:14: SEQUENCE CHARACTERISTICS: LENGTH: 411 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO ,vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-.feature LOCATION .411 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:14
ATGCCCAFI'A
GTGATTATCC
AAATACCAAA
GAGCTITTTAG
CTTI'TAAAAG
TGCGCGAAAA
TACGAGCTGT
AAGGCTCT
CCCAAGCGGA
AACCCTI'GTI'
AAAA.AGGGCA
ATI'ACCATIT
ACCCTAGCTA
T1GGGTAAGAT
TTTAGCCAGA
TTTAAAAAGC
TGTITI'ACCC
GGCTCAAGGG
AAAAGAAATG
TGAAGAAGCG
TAAGCGCATC
AACCGCCTGG
GGCTCTATGA
CAACGCCTGA
ATATTTAATA
CCTGAA.ATGA
TATCTCAAAT
AATCATCTCG
TGATCGCTTTr
GCAGTGCGAG
ATGAGAGCGA
TTCAAAATT
AAGATGAATI'
TIGGGGATAA
TGGTGTI'AGC
AACCGATGCG
ATTAGCCCAG
CGGCACTAAT
TATAAPLCACC
TTrAGA.ATAT
GCTTITAGAA
A
120 180 240 300 360 411 INFORMATION FOR SEQ ID SEQUENCE CHARACTERISTICS: LENGTH: 816 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO
-RAI
(<41 i-ui/LS 9 6 /09122 IPENUS 18 DEC 1~996 127 (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .816 (xi) SEQUENCE DESCRIPTION: SEQ ID
ATGGTAGTAG
GGCGTGA6ATT
GGGAAATCCA
TTIAGTCAATG
AAAATAGGCA
GTCGCTTTCG
GAATITG?1GG
GGCGGGCAAA
CTTTGCGATG
CTAAGCGGCA
GTGGTI'AAAG
GGCTCGGTG
ATCAAAAACG
GAGCATITAG
AATTAAAAAA
TGGAATTGAA
CGCTCATTCG
GGGTCAATCT
TGATTICCA
CTCTAGAAAT
AATI'AGTGGG
AACAACGAGT
AAGCCACATC
TTCAAAAAAA
AA TTGTGCAA,
AAGAAATT
AACATGCGGA
ACGAGCCGAT
CATTGAAAAG
AAAAGGCGAT
CTTGATCAAT
GTTAAACTTA
GCA'FITCAAT
CGCCCGATGG
G'ITAGAAGAT
GGCGATCGCT
CGCTTTGGAT
GTTGAFI"TG
TCAAATGTGT
TGCTAACCCT
TCAAAAATCG
CATT'TCTAAW
A'TI'ATGAAA
AI'TTGGGCG
TGTTTAGAGC
AAGCCTAAAG
TT1ATTGAGCG
GAAAAAACTA
AAAGTGCAT
AGGAGTTAG
TCTAAAACCA
AGCATCGTI'
GTGATCAGCA
AAACATGCTG
CAAGACATT
'rrrroW ACGGGTTrCA
TGATAGGCTA
GCCCCAGTI'C
A6ATTGCAAAA
CTAAAAACGT
AGATTAAATC
TTTATCCTAA
CGAATTGCCC
CGCATTCTAT
TCATCACACA
GCGGCGAAAT
TTACTAAAGA
ATCGCATCGT
TGCTCTAAAA
TTCAGGGGCG
TGGCGAAGTI'
AGCGCGCCAA
GTTTGAAAAC
AAGGGTGCAT
ACAGCTCAGC
TAATTGI"G
TTTAACGCTT
CCAGATTGAA
CGTAGAAAGA
XITTGCTI'GGC
GTTTTTAGGG
120 180 240 300 360 420 480 540 600 660 720 780 816 INFORMATION FOR SEQ ID NO:16: SEQUENCE CHARACTERISTICS: LENGTH: 318 base pairs TYPE: nucle-ic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .318 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:16 ATGGGGGCTr
GAAGATAAAA
GCC TrTAGCT
ATCCAGCTCG
GTGTTAAAAA
GTCCCTIGA
TGATAGCCAT
AGAGCGCGGC
GGTATFI'GAT
CTTGCGGTTG
AAGCCCCGCA
7rITTTGCC
GTTTITA
'TTTAAAGGTC
CGTGAAGGTT
TGTCCITGCG
ATrTAGAAAAT
ATGCTCATTA
GTGCCTTATI'
TI'AAAACGCC
CTITI'GAT?1'
AGCCACGAAA
AAAAGACTAT
TGGTGGCG IT
TCTATGCGGT
T1'ATCC 17171
GCGTCAATGA
CGCTrATAAA
GATGAGCTITA
GAGTTI GAA
TAAAAGA'TTT
GCTTTTAAT
120 180 240 300 318 INFORMATION FOR SEQ ID NO:17: SEQUENCE CHARACTERISTICS: LENGTH: 471 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) 1 z
AK
PGTus
IPENUS
96/09 12 (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .471 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:17
ATGATI'AAAA
GTGAATGGGT
AATI'ACTCTG
GTAGGCTI'G
ACTTCAGGGA
XITTGTCAATC
GCCGGAAACA
AATITAGGCG
GAATTGCTTG
TTITCATGGG
ATTGGCGTCA
CCAATAAATG
CTGAACACAC
TCATTCCTT
CTTGGATGT
GAAGAATGCG
TA'FTI'AAGC
TGCGGGTI'AT
TGGCAATGAC
GTTTGGGGCT
CAAAACCAAT
GGATAAATTC
CCCTrATGAT
TGTTGGGGAT
TTGAGCGCGA
CAACAAGGTC
CTTTATGGTT
AGGGTGTATG
TTGCTCACCT
GCTCTAGGTC
GTCAATCAAA
RCAGTGCGTT
GTITAGCGTI'
GTTAT GGCCC
TGAATTTCAA
GCTTTTTAGA
ATGGCGGCGG
TCA PTGGTGG
CCAGATTCCA
TGAAGCGGGC
AGCTGGCGAA
TTATAACAGC
ATTAGGTITT
TI'GGTTTAAC
TGGCGATTTIG
CGTTCAATTA
GFI'CFTATGG,
G
INFORMATION FOR SEQ ID NO:18: SEQUENCE CHARACTERISTICS: LENGTH: 834 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (geriomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc-feature LOCATION .834 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:18
ATGTATCGCC
CTGTAACC
ATGGTGGTGG
ATI'GAGCCTA
AAAAAGATCC
TTTTTCATCT
GGCCAGTI'GT
'TTT1GTCT
AAAATGACTA
AAAGCCAAAA
CCCAAATCCA
GAAGAACACC
AAGGGTATCG
CTITTATAGAG
ATGTGTI'GAA
AGCTGGCTAA
CGITI'1'TGTC
AATTTTCTAA
TI'GATGGGAG
TTTCCTI'ATT
TGTGGTTTAA
TGGCT'TrGT
AACAAGAAGT
TCCGCCAGAT
ATGTCGTGGT
CTGTGCCTGT
CCAGAGAGCA
ACGTGAAAT'
AGATTTCTCC
AGACACFITI7
TAATGTCTTG
AATCAACCCT
TTTGATCACT
ITAGGGGAA
AAGCAAGGCG
GGATTI'AATC
TAAGGACGAA
GATGGTAAAA
GACTAACCCT
GGTAGTGGCT
TGACATAGAA.
GAACGCCACC
CTAGAI'TTA
TTATTGCTI'
CAATTI'GGCT
ATCAATGGCG
TI'AAAAGTI'
?I'AAACCATG
?1'ATGGCTCA
ATCAAACGCC
TACAAACAGC
AACGCCACGA
ACCCAITATG
AAAGGCACGG
ATTATAGAAA
ATACCAGAAG
GCAAAGAAAG
TGCCTGrTr
GGCTCTTTGC
TCAAAAACCT
TTI'TAGCI'T
CGGCTCTITI7' Tr'rCTl'CGCT
GCCAATACAC
AAGAAGGAAA
ATAAAATGAT
CCGTCGCTCT
ATTATTTAGC
ATAAAACGCT
AATTGTTTGA
CGTTCAAGAG
AATCATTA
CCCTAAAGTC
T TrCTTTA
TTTTCTGGGG
GAA'ITTGCAA
TTTATITTA
TAACTCI'IA
CCCAGAAATC
GCAAGAAATC
CAAATTTGAT
CATTAGGA LT
CGCTAGAGAG
GCGG
120 180 240 300 360 420 480 540 600 660 720 780 834 INFORMATION FOR SEQ ID NO:19: 1po" 18) EC 199S 129 SEQUENCE CHARACTERISTICS: LENGTH: 360 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .360 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:19
ATGAATACAA
AGAGAGCCAG
AAGTTCGCGC
TACCITTTTAG
TTCI'GCATA
TTAGTI'GCGT
GSCCCT1'AAT
TI'TCITI'TCA
ATG TTCTAG
AAGACAGAAG
AA.AAACAAGA
TATTAITAGA
CGCTACGCTT
GCCTTI'AC
CATGCCCAGT
CCTATTGGAT
ATTTGACGCT
TGCGAATTTA
TTGCAAGCGC
CCCAAAACAG
TTGGAATT
T1'AGCGGTGG
TTATGTCAAG
CCC CTAAAAA CT ITGCATGT
AAAAGCCTAA
TAGAAAAATI'
G'ITATATCCA
AAAAA'ITGGA
AAGGGGGTT
TTTAGGGATT
TCGCCCTCAA
GGTGATCCGC
TAGTGGGGTA
CGACCCTAAA
TGAAAFAGGAA
120 180 240 300 360 INFORMATION FOR SEQ ID SEQUENCE CHARACTERISTICS: LENGTH: 678 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 678 (xi) SEQUENCE DESCRIPTION: SEQ ID
ATGGGGCAGG
TCTAGCGCAA
GTGGTGAATA
TI'AGACAATG
GGTTCAATA
TCGGTAAAAA
GAITACCAAG
T'IAGAAGAAC
GCACAAAAAG
GAAAATCTCA
GAATTGATCA
~>GCAAGAGCAG
CATrrrTTAA
TAGAAGCAGT
AGAAGATTGC
TTACCGTGAT
AAGGTI'GGAG
GTAATCTCAT
AATTTTTAKA
AAAAAAAAGC
ATAAAAGAGA
CTAACGCTAT
AGCAACAGAG
GCTCAAGC
AAAAAIWIGTT
AGCACTTGAC
TTA'ITTGGGA
CCAACTI'GAA
TATTGTGCCT
GTI'GAAAAA
GACAAAAAAA
TCTAGAAAAA
AAAA.AGAAAG
GAGTAACCCA
AGAAAATGAA
GGCTGITTTCT
ATTAAGAATT
GATGAAAAAC
AAAGATGAAA
AATTCTAATC
GAAGCAGTGA
CTTATCGTAG
GAAAAAGAAG
GAGGAGCGTG
CAAAAT'ITGA
'ITAGACCAAA
GTCT'GGT1'A
TTAATCGTGG
CTATTACGAT
cTATTI'CTTA
ATATATTCAT
A'I'I'TGCCCT
ATGCGCCTGA
CTAAAGAACA
CAAAAAATAG
GCAATAACAA
TGGAACGAAC
TTTAITTTTA
TAGGGTGAAA
rI GGACTTCA
CATCACAACA
TCAACCTAAA
AATGACAAGA
CCCTAAAGAA
GGCGCAAAAG
AGCCAATTTA
AAATCTTAGC
TAGAGGACAT
120 180 240 300 360 420 480 540 600 660 678 PGT/US b/ u Vi IPEA/US 18 DEC 1996 130 INFORMATION FOR SEQ ID NO:21: SEQUENCE CHARACTERISTICS: LENGTH: 150 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...150 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:21 ATGAATACAG AAATTTTAAC CATCATGTTA GTTGTCTCCG TGCTTATGGG ATTGGTAGGC TTAATAGCGT TTTTATGGGG GGTTAAAAGC GGTCAGTTTG ACGATGAAAA ACGCATGCTT 120 GAAAGCGTGT TGTATGACGC GCGAGCGACT 150 INFORMATION FOR SEQ ID NO:22: SEQUENCE CHARACTERISTICS: LENGTH: 390 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...390 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:22 ATGTTTGTAG CGGCCGGGCT TGGGGCTTAT GCGATCGCGC TTTTCCACCT CTTTACGCAT GCGTTCTTCA AATCCCTCCT TTTCTTAGGC TCAGGCAATG TCATGCATGC GATGGAAGAC 120 AATCTGGATA TTACTAAAAT GGGCGCTTTA TACAAGCCTA TGAGGATCAC AGCTGTCTTT 180 ATGATTATAG GGTCAGTGGC TTTGTGTGGG ATCTACCCCT TTGCGGGCTA TTTCTCCAAA 240 GACAAGATTT TAGAGGTCGC CTTTGGGATG CACCACCACA TTTTATGGTT TGTTCTTTTG 300 ATTGGGGCGA TCTTTACCGC TTTTTATAGC TTCAGACTCA TCATGCTGGT GTTTTTTGCA 360 CCCAAACAAC ATGAAATCAA CCACCCCCCA 390 INFORMATION FOR SEQ ID NO:23: SEQUENCE CHARACTERISTICS: LENGTH: 549 base pairs
,A^
J/09122a IPEA/US 18 DE C 1996 TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL.: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .549 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:23
ATGTTTATAT
TTCAAAAATA
AATATCGCT
TTAAGCCCCT
AAAAAGCCCC
CTT'=ACAG
CTGAT'T1=IA ATCGC7=AG
TCTIATTGG
C'ITCTTCTTA
AGCCAI'GGG
TGAAAGACTC
TTAGCTGTCT
CTTTAGAAAC
ATATTTTAGG
GCGCGCTTI'
TGGCTT'ATC
ATTICCCAT
CACGCTGAGT
ITTGAGG TT
CCTATCGCTC
TTTGATCCTT
CTTGCAATCT
GTITTrGCCT
TTGCAGCAGT
CAG ETICGC IT A TrCTT
TTGTATGGC
TCGCTCTCTT
AATGAATITTP
GCTATGCAA
TATAGCGTCA
ITITCAATCT
TTGTFI'TGA
TGATGCGI'
GTCTTTTI'A
TTI'TAAT
TGATAAGCGT
TAAGCAGT
GCTITCTI'G
TGCTG'TTI'
ACCATCATT
GTAGCCCCTI'
CTAATITI'CA
AGAC'TTATA
TI=CTTIT=
GATTITAAGC
TACAGCCCCC
CCATATACTC
CAATCTGTTG,
CATGGC'ITCT
ATTAGGCGTG
AATCTTAGAT
TCTTGCTAAA
AAAAGGI'A
INFORMATION FOR SEQ ID NO:24: SEQUENCE CHARACTERISTICS: LENGTH: 705 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) IFEATURE: NAME/KEY: misc-feature LOCATION .705 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:24
ATGCGCCTAG
GCGTTGGTT
ATCGTTAAAG
GGGGAAAAAT
TTAGATGTGG
AAGGTGCTTT
CGCATAGAAT
TTAGCACT
?I'AAGCGGTG
CGCAATAAAA
AAAAACCATI'
ATTACGCCCT
TAAAAAAACA
AGGGCGATCA
TAGGGGCT
GAGCGAGTAA
GCGTGGATGT
G ETACGAAGA
GTGATGTGAG
AATTTAAC
AGGGGGTGGT
TAAAAACAAA
ATCAACCAG
GG'rITrAGTC AA ITGAACTC
ITI'AGAAGAT
GGGAGGCTTT
GGGGAAAATG
ATGCGATATT
CT'IA TrCT
GCTTI'TCAA.A
GATGGATAAA
GGATTCAA
CAT1'TAGCAA
AATAAAATGG
ATCGCTCCCA
CA'rTIATAG
AGTCAAGTGG
CAAI'AGATG
AGAGGG ITA
TTATATTGTA
CCGCAATTG
GAAGCCATT
ATCTTAACGA
ATAGCAGAGA
TGGI 'CTA.A
ATCTATTCGT
ATTTAAAGA
CTC'FTIA.AA
AAAGTTTGAA
AAACGCCAGA
TTTTAGAAGC
AAGTGGGCAG,
TGAACGC TIT
TCCAAGAAAG
AAAAGCTAAA
ACCCTCITIT
TAGCAGGGCT
AAAGGTTGTT
AGGGGCTAA
AAACGACCAA
AAAAATTGAT
GATTTTGCCT
AACAATAAAA
AGAAAACT
CTI'AGTGAAA
120 180 240 300 360 420 480 540 600 660 AMENDFD) qHFFT
'PEA/US.!
uC j 96 GGGAAAAACG GGAATGTI'GA ATTTFITTATC CATITTCAAGC GAGCC INFORMATION FOR SEQ ID SEQUENCE CHARACTERISTICS: LENGTH: 264 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .264 (xi) SEQUENCE DESCRIPTION: SEQ ID
ATGAGCCTAC
TCTITGGTGG
AACGCTGACT
GCGAGCGGCA
AAATIT=AG
CACCGGTIG
CGTTAGGCAA
ACATTATAGA
CGCCTAGA
C TIGGAATT CAT TTGAAA GATGTGAATC TTCCATGCTA GTGATTGAGC CATGGGGCCT GATGGGGGGG AGTGGCGCAA AATTGCGAAA
GAAA
ACCTITACA
ATAATl'AGA
ATAAGGGCGG
AAACCCAAAG
AGTCITRCAT
CATCATCAAA
GAAAGTCATI'
CTATACGGGA
INFORMATION FOR SEQ ID NO:26: SEQUENCE CHARACTERISTICS: LENGTH: 444 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .444 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:26
ATGCAAAATC
TTCACCAAAG
GCGTTrGT
GTGGTGTTTG
AACTATITGA
GTGCCTFAG
AGAATCTATT
AGCCCACCAC
GATCGCATGA
AGCTTGACAA
GGCTCAAAAT
AGAGCATCAA
TGATGGGGGA
AAAATTGGCT
TTGAGGATAG
AGAGACAATT
AATACAAGGC
'TATATCAGC
CGTAGCCATA
CGCTACAGGC
AAATYCTGAC
TGGTGAAAAG
AGTTACAAGA
TCCC
GTATCACACA
AAAGGGTATC
GGTTTAGAGT
GTGCAA?'A.A
AACCAGAATC
GATI'TGAATG
GGGAGAGCGC
TTAAGAATAA
GCAT1'GAAGA
TGGGCGAAGA
AAGGGCTGGA
GTC'TTATAA
ATTTCATCAA
GAAGTGTATT
TTATAAAT
GATTI'ATGGC
CGATCCGCAA
TCTCATCCGC
TACITAT'GG
AACCTATIG
ACGCGCTAAA
120 180 240 300 360 420 444
N
AmENDED SHEET INFORMATION FOR SEQ ID NO:27: SEQUENCE CHARACTERISTICS: LENGTH: 321 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (geriomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .321 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:27
ATOGATACCA
AAATGTGTG
ATTCTTG'ITA
TTTGAATACA
CATGTGTTCT
AAATATCATC
TAAAAAGCAT
TG ETGGCATC
TGATAAAATT
GCTTGCTGTT
CAGGAAATrT
ACTCAGCTTG
TCCCATAAGA
AATTACAGTG
GATTGATATT
ACCAACTTTA
TATCAAGC T
ACTTTTAITI'
CTATIGTCG
GTGGTGAATC
CTACTATGGG
GCAAACCATT
TACTCTATAA
GCATTCTTYC
TATI'ACAAAA
GAGCCTTGCT
ATTGCCGAAC
AAGCTCACCA
ATCTCTGAAT
GCATACGCAT
GTITrAACG
AATTCTAT
INFORMATION FOR SEQ ID NO:28: Ci) SEQUENCE CHARACTERISTICS: LENGTH: 408 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (jv).ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori Cix) FEATURE: CA) NAME/KEY: misc-feature LOCATION .408 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:28
ATGATCTTT
T'ITTTTGGCA
ACCTATTCT
GACAGCGCCC
AGCTTGAATA
ATTAGCGGGT
TATACCCCCT
ACACCACCAT
AGATCAAGCC
TTTCTTTAAC
ATTCCAACGC
AAGACTTAAG
TTCATTTAGG
TACAAAAACG
TAAAGAGCCT
TTGTTICGTTC
GCGAAAACAA
CTTAGTGGGT
AGACAGGGCT
GATT1'TGAGC
CTATI'TCCCT
TTAAAAACC
TTAGAGTCTC
GA=IICAAAT
AATTTGTATC
AACGCGCTAG
GCGAGCGTGT
TACAGGAACG
TCCAATACCG
TAAAATCATG
CGCATTTGCG
GAGCGTAT
GGATCAACCA
AT-ITTCT'TTT
CTTITIWA
CTATGCGCAA
CTTTTTTCAA
CCAT1'CA'T CATACuGGGAT
CTI'ACTGGCC
CTCTCTTI'
120 180 240 300 360 408 'K INFORMATION FOR SEQ ID NO:29: 4, LENGTH: 384 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION I1.. .384 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:33
GTGATGGCTC
ATGATCAATC
TATCTTGTCA
ATTTGGGCGA
TTGTTGATGC
AAAGAAAGGA
CTTATCATCG
AATCCTTGCT
TTTACACCCT
TGCCAGCGAT
TGCAACAAFI'
TCATTGCAGA
TGAAAGCCTA
TGTI'AATGGG
TGTYCATGCC
TTTAAAGAA
TTATATTCT
TGAATT'FrCT
AATCAAACGC
TATCAAAAAA
CATI'
TTIT1'TCCG
AAGAATTTCA
?I'AAGCATCG
TI'TAGCGCTG,
CATAAAAGCG
GCTAAAATCC
CCTTGCTCGC
TCCAATTGAA
CTC'?TI'GAG
TTGTCATGCT
TGAAATTCGC
TGTATTTT
CCTAGCCITI
CCGGAAMA.TC
TGGGGTFTTT
TTTGGGGTrG
TATCACTAAA
AGAAACGATT
120 180 240 300 360 384 INFORMATION FOR SEQ ID NO:34: SEQUENCE CHARACTERISTICS: LENGTH: 306 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc_feature LOCATION .306 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:34
GTGCGTAATG
AGTIATI'GCA
AATGAAAATG
T'TGTGCAAA
ACGCGCITTTG
AAAGTT
TGGTTTITATT
TGCCCCAT'A
AAAACACGCC
CI'ACGACCC
GCTTCCCTTI'
CATTI'TAACA
TAGCGTGGCT
CAATAATAAG
TAAGGATCAA
TTA'FTI'AAG
GCGATCTTT
GTCATTAGCG
GAAGTAAAAA
AAAAGCGTGA
TTTAATTCGG
TAGCGT1'CAT
GGGTGGAAGT
CCCTI'GCTAG
CCGTCTATCG
CTGATAT?1C GCT1TI'AGTG
CAAAAGAATG
AGATGTCTAT
TAACGAAGAC
AGCTCTCGCC
INFORMATION FOR SEQ ID SEQUENCE CHARACTERISTICS: LENGTH: 264 base pairs TYPE: nucleic acid AMENDED SHEET CT/9 96/09 12a )PEWIS 18DEj' 1996 137 STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .264 (xi) SEQUENCE DESCRIPTION: SEQ ID
ATGTTTAAAA
CTTGAAGCCA
GAAAAGCTCT
TATITTI'AG
AAAGATTGGA
AAATCATTTT
TGCCTATTr
ATAGAAGCAT
GGGGGG ETGG
TGCCACGCTC
TrTGTGCGTT ITI'TTGATAG GCGCAATAAA ACCCCCAAAA CATrAACCGC CAAAASSTCA CGCTGTAGAA GCCAFI'AAGG
AATT
GGGGATTTGT
AAAATTACCA
CGCGTAAAAA
ACTATCAAGG
CATI'CCACCC
AGAAGCCCAT
AAGCGGGTGG
CAAGGAAATG
120 180 240 264 INFORMATION FOR SEQ ID NO:36: SEQUENCE CHARACTERISTICS: LENGTH: 384 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .384 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:36 GTGCATTA CGTGTATCTI CAGGCGTGCA AAAAGGCCAC TATCCCCCCT CAAGTATI'AA TITGGGGCTT TGAGCAGCAY TGGATI'GGGG GCTI GAGCA GGTGCGCA'IT GCGAT'ITGAT GGTCTTCCAC C ICAAGGG
TCTAACCCTA
CAACCAGATC
CCCCTCAATC
YTTAGAAGYC
TTATITATCC
GCAAAAAGAC
GCTG
TTAAAATGGA
CATI'CAAGGY
CAAGCGGGTA
CCCYTAITTG
CCI'TATATG
GCCAATGGAA
?TTGCCAGC
YTGCAAAACA
TACAAGGGGT
rTTTYYAAGC
GGTGGGGCAA
GGGGTATCGG
CAAAAACAAG
TCCAGCAAAA
GATGCAAGGT
AAAATGTGGG
GArrrCACGAT
CTTGGAAAAA
120 180 240 300 360 384 INFORMATION FOR SEQ ID NO:37: Wi SEQUENCE CHARACTERISTICS: LENGTH: 324 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular
L
3~7'FT- C I I dwwwl m ii ,Jq, 96/09122a IFEN/US 18 0EC 139 SEQUENCE CHARACTERISTICS: LENGTH: 162 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .162 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:29
ATGAATAAAC
AGAAAATACT
TGCAAGAAAG
CA'ITI'AAT CrI'ACTCATA GCCCTAATTG CC'TTTAGCGG CTGTAACATG TCAAACCCGC TAA.ACACCAA ATI'AAAGCGA AGCGTATTI'C CCTAACCATT CATCGTI'CG TCTAATCGTT ATGGAGCCAT TT INFORMATION FOR SEQ ID SEQUENCE CHARACTERISTICS: LENGTH: 375 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .375 (xi) SEQUENCE DESCRIPTION: SEQ ID
ATGGCGGCTI'
GGTTTrGTGG
ATCCATGCGG
TTrAATGAA.A
GAAAGGGGGA
TITTTTAGGGA
AGGCTI'GAAA
GGAACACTr GCAAGTA'TrT
GGGCGCATCT
AGACTGATrT
TTGAGGGCAA
TT~GTTGGG
GGC
AGTAGAAAAA
AAGCTI'AAAA
GGATACGCAA
AGAGGGCGTT
AATI'TGCGCC
CATGCAATTA
ATCATCGCTC
GAATCTIrATA
GTCAATATTG
GATGCGATTT
ATTCAAAGGG
GCGATCGTTG
CTAAACACAA
AATCCI'GAT
AATGGCTGGA
TAGTGCCGGG
CTAGGTTAGA
AATITGTCG
GGTCAAAATT
TGAAGCCCTA
TAGCGAGAAT
GGGCITTGGA
AAAACTCCCC
CAAATGTTr INFORMATION FOR SEQ ID NO:31: SEQUENCE CHARACTERISTICS: LENGTH: 747 base pairs TYPE: nucleic acid STRANDEDNESS: double 4K ~4K'r C It..
1-6/91 a22 PEAJUS 18 DEC 1996 135 TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .747 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:31
ATGACTAAAG
CTCATCTTAA
AAGATTGACA
TATGTGGATA
CTCTCTCAAG
TTTGAATTGA
GTTGATTTG
GCTTA TrGC
AATAAAAATC
AGCGTGTTTT
TATTTCYAWG
GATTTGTT
TTTAGAAAAT
CGI'TGTGCC
TCCCCACTC
TTAACATCAG
AGACTGAAAA
AAAGC'ITTAT
ATrGTATAA
AAGAATITGCA
AAGGCACGGA
AAAAACGCCG
TAATCCCC LT
TCCFI'GGAGC
TGATGACCT
TCATTITAAA
=TAAGTTTG
TAAGAGCGCT
AGCGGGTGAA
CAATTrCCTAT
ITTTGGCTCAA
CGGGCATGCG
?IWIGCGCAAC
TTATGGGT
?TT=CTCAA
ATTI'GGCATC
GGTTIGGGGTW
'FI'ICITCCCC
GCGTTAT
'FTAGTGAGCG
TATTACGGGT
TTCGGGCAAA
GATAA TTGG
AAAGGCAATA
TATI'TCACTC
AAGCTCAAGT
TATTGGAAAA
GCGATC'ITAG
GCCAACCCGC
TATTTTTTAA
TTTATTTGGG
CGTI'TATT
TTTTGCGTCA
AATTAGGCGA
TGCIIIIC
TCAACAATCA
AAGGCGATAA
CTITCAATTC
AAGCCI'TGG
TTI'CCTTGT
GATTCAAAAC
TGGTGCATGT
CG'ITTATTTC
AGCGTTTTCG
AAAAAAAGAC
TTGGCTCGTG
TAATAAAAGT
AAACGGCGTG
AATGCGTAAG
TAATGATGCG
TAAAAACGCT
CCCT N'AGCG
GAATTGGAGT
GATTTCTACG
TTATTI'ATTG
120 180 240 300 360 420 480 540 600 660 720 747 INFORMATION FOR SEQ ID NO:32: SEQUENCE CHARACTERISTICS: LENGTH: 258 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .258 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:32
ATGAGTAAGA
TTAFI'ATATG
TTAAATAAAA
AAGAATGAAA
AGAACCCAAA
GCGCGATT TGTTCTTI'CT GGCTTrAG GTTTGTTGTI' AGAAAGGCAT AATAAAGAAG AGGACGAACA AGCCAT'TGAC TTGAATITAG AAATTRAAAA AGTAACGGAA AAACAGGACG
GAGGAGCC
CGT1'CTTGCT
CAGAGAAAAT
AAGATCTGCC
ATTTIAGA
CTATGCTG
ccT TTAGAT
AAGCGAGAAA
GCCTAAAAGA
INFORMATION FOR SEQ ID NO:33: SEQUENCE CHARACTERISTICS: A% irlImtr' eurrT r-~Y Poo 96/0912.2.
IPEN/US 18 D EC996 138 (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NANE/KEY: misc_feature LOCATION .324 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:37
ATGCAGAAGT
TTAGCAGCGA
GATCAGTTAG
ACCGATCACT
TAGAGCCTA
AAAACGGTTG
TTTTCTCTCG
TTGATATrGA
TGAGCCTGAG
TAAAAGATCT
AGCCTAAGGG
AAATCGGAAG
~TTAGAAGG
TGAAGTAACA
CGATAAGCT
TAACGATTG
CAAAGAAGAT
CGGT
TGGGCGTTGC
GAAGCTCAAG
TTAGAAAAAG
CATGAAAAAA
AGTCCTAACT
CCTTATI'
CTAATAGCAT
CGGTGGATAG
TCAAACATI'I
TGGGAGGTAA
TGTGAGCGCT
TAAAI'AAGC
GGGGCGCAAT
GCGCTTGATI'
TAAGGATATG
120 180 240 300 324 INFORMATION FOR SEQ ID NO:38: SEQUENCE CHARACTERISTICS: LENGTH: 354 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .354 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:38
GTGATI'TAG
TI'AATAGGGA
CCTGCTGGGA
CTGTATITAG
TGTTCAGGCT
CGI'CGCC T
TATCCACAGG
TTAGCGGGAC
TCATCGCCCC
GCGATACA~r
TGCTCATI'GC
TGGCATGAGT
CGTTCATATC
TTTAGGGCAG
CATTGAATAC
T1TTGGATCTT
CTTGCCCGCT
CTTCTTGGAT
CCTAGAAAAG
TATTrCTTAA
ACCCGCATI'G
AAAAGCTCTI'
CTlTTAAAAG
TAGCGGGCAT
AGGATTT
CCTATGCTTA
TTrGGGGGCT
TAGGGGTGGC
AATTAAAAAA
GI'CATTGAT
ATGGATTTCT
CATGAACGCT
ATTGTI'TGGG
TTTGATCTI'A
AATT
INFORMATION FOR SEQ ID NO:39: SEQUENCE CHARACTERISTICS: LENGTH: 162 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO A&Acmn C1C 14rFT IPEMS 18 DEC1996 139 (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1 162 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:39 ATGATCTATT TAGGGAAGAA AAATTITAAC GCCCT'ITGA, AAGGGGCGTA ITTAATGGAT GAGCATI' TA GAAACGCCCC T1TTI'GAAA.GC AA ETTACCCG T'ITAA.TGGG ATTAATCTGG 120 CGTGTGGTAT ATCTAACTI' TI'CCAATC CAAAAAGCCA CT 162 INFORMATION FOR SEQ ID SEQUENCE CHARACTERISTICS: LENGTH: 864 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .864 (xi) SEQUENCE DESCRIPTION: SEQ ID
ATGGCCGCCA
AAAATCACTA
CGTAAAGCCC
ATAGAAACCG
GGCGAAGCTA
CTCCCTI'CTG
ACCAATGTI'G
GACTITAATG
GTIT1'AAAAA
AGCGGGTGCG
GGGGAAATITr
AAAATAGGCT
GC'FTIGGGA.
TATGAI'?rT
TTAGCGGCGG
AATCCAAAGC
AACTCAAAGA
ATGACACTGA
TGGGCTTTIAG
GAATGGTACT
TAACTGGAGT
TTI'AAAAG
AAAAAATCAC
ATTTCAACCT
GAAAATCCAC
TTATITGATAA
ATATCCCCCA
GTGCTATAGA
TATGCGAGCA
TCAAAAACAG
GYAAACGCTI'
CAACCACGAA
GATCA TTAC ITrG TrGATI'
CCCTACCAT'
GATCAGCTAT
CCTTCTA.AG
TCTCCAAAAC
CACCATTCAA
GCTGGCGGAT
CACCC TITTA AAATATrTAC
TGAAAAACGC
TGAGGGCCT
CGCA
AAAGTCTTT
GAAGCCCACA
TCCACTTTGC
TTIAGCGGTCG
TCTATGTATG
TATAATGAAA
ACCATCGTI'G
ATI'TCATTCG
AAAGGTCAAA
ATI'ATTATGG
ACCAGCGAAA
CT1'?IGATG ?1'GATI'AAGG
AAAACCCAAG,
CAAAATT1TTI' AACTT1'TGG
AAGTGGTCCC
CTTACATCTI'
CCCTAGCGCT
TCGCTI'ACAA
AAGAGGATTT
CTTATAAGTC
AAA.TCGCTCT
GGCTI'ACCTA
ACAGGCGCTC
GCA.CTGTGGG
TGTGCAAAAT
TGGGCGAAGG
CAGCAATTTC
AGAAAATAGC
CAGGTATICA
ATTCAAATAC
r1ATCGCATA
CCAGCTTGCA
AGTCCCTTTA
AAAACACCCG
CATAGGCCAT
CCCTAAAAGT
ATGGCGTAAA
GGATAATATC
GGCTCATATC
GGCGCTAAGC
120 180 240 300 360 420 480 540 600 660 720 780 840 864 INFORMATION FOR SEQ ID NO:41: SEQUENCE CHARACTERISTICS: LENGTH: 576 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular If-%rCC11 09JfU12 IPENUS 18U0E C 1996 140 (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .576 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:41
ATGCTTGATA
CCT1'ACAT1'G CCTGT TTAC
CAATTATCCA
GGTTTGACGC
TTGGTGTTTG
TATACTACCA
TTTAAGGATI'
ACTCTCATAA
TI'TGTTTTCA
TATGGATAGA
TAGGCGATAT
TCCCACAAAA
TTATTTICTCA
ATTI'AGAAGA
CCTTGTI'GTT
TGCATTI'GGA
TITTCAAAGG
TGATCA ETGA
TGA?'IGC
TATGATAATC
TI'TGCAATI'G
GGATTATGAA
ATITrAGAT
TCTCACGCAT
TTI'AGCGAT'
TAAGGAATT
ATI'ATrGCTC
ACATGTGGAG
TAATCTT
TGTATITT
AAA'ITTATCC
GAAGCGGGAA
GGGGTGATCT
TAITTAAACC
CAAAGCGTT
GGCIrIrCTA
AC'TTIAGGCG
CATGGGAGA
?I'ACCC
ATI'GCTCTTI
GTCAAAAACT
ATTATGCTAT
TTGCTGGTI'G
TTCCTGAAAC
TAGCTTACC
AGGTGAGTT
TGGGGTTGTT
TCAGCTCGT'
TITTACGACT
CTGCGAGAAG
TAGGAAAATG
GGTCTTT
GCTAGGTTAC
CATTAGCTAC
ATCGTTGTT
GTTGATTAC
T*I=TTCGTG
120 180 240 300 360 420 480 540 576 INFORMATION FOR SEQ ID NO:42: SEQUENCE CHARACTERISTICS: LENGTH: 504 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .504 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:42
ATGCTAAAAA
TT TTTACGGG
TTTGTGGCTI'
CAAAGCTTI'
GGGCTATI'
TGGCTAACCA
ATTGTAGCGA
CTTTI'ACAAT
CATGATTA
AAATATTT
ATrI'AATGAT
TCAAATI'GCC
TACCGAGCT'
TI'TGTGGCGT
AACTCCTAGC
TCAATTTG
ACAAACACAG
GCCCTTGA
AACCAACAGC
GGCCAATATC
TAATCTATTIC
CATACGGAGT
TTI'AITCATIG
TrACGGCrrrr
GTATCTTI'A
CTFT'TGCC
TTTC
TI'AGGGAT1T
CTAGGGGCTG
AGGCGTATIT
TCCATI'AAGG
TGGTGCTTAT
GATGAAGAAA
TIGGTGTTrA
GCGCTTATGC
TATGCTCTAG
GGGTGTATAG
TTGCGGAGGG
GGGGTTITGC
TAGTAGCGCT
CGCTCAAACT
TCACCACT
GCAAGCTI'AC
GATIrTIGGC CGATAT11WTC CTCTrIT1IICT GAGT1TGGTG
CAATCCCI'A
ATGCACCCCT
'TTTAGGCGCG
TCAATTTATG
120 240 300 360 420 480 504 INFORMATION FOR SEQ ID NO:43: Wi SEQUENCE CHARACTERISTICS: LENGTH: 459 base pairs PCT/US 96/09122.
PENUS 18 DEC 1996 141 TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION .459 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:43
ATGAATTTAG
GTTTTAAAAA
ATTTTAATAG
CGCATCTTTA
TTGGTGCTAG
GAAAGAATTA
GCCTTGTTTG
GCCAACGCTT
AAGTGGCTCT
ACCTAAAGCC
ATGTGGGGCA
ACGCTCCAAT
AAATTTTAAA
TCCAATTAGA
AAGAACTGAA
TTTATGAACG
AAAGGCGTTT
CCTAGATTTA
TAACCCCCAT
CGTTTTGATT
GTCTGTGGTT
AAAACTTAAA
AGAAAATGAA
CTATCCAAAG
GAAACGCTAT
ATCGGCCGTT
AGCGCTAAAG
TATAATTGCT
AAAAAGGTTT
GGGATTTTAG
AATTATTTGG
AAGAGGGAT
TGCCATGCAA
GCGAGCTTTT
CCTTAAAAGA
ATCAAGATAA
TGATTTTAGA
AAACTTTAGG
TGTATGGCTC
TAAACAAGAA
AAGCCCTAAC
AGAAATCAAA
AGACGCTTTT
ATTGCATAAT
GTTAGAACAC
ATTTCTGGTA
120 180 240 300 360 420 459 INFORMATION FOR SEQ ID NO:44: SEQUENCE CHARACTERISTICS: LENGTH: 177 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION .177 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:44 ATGGCTATCG GGTTTCCGTT AGTGTTI'GGG ATTTTACTCA CCCTTTTTAG CCGTTCTTAT TGGCGTGAGT TTGGGGGCGT TTCAGGGGTA TTATGGAGGG CTAGTGGATT TAGTGGGGCA AAGGTTGAGC GAAATTTGGA GCGCGATCCC CATGCTTTTT TTACTCATTG TGATTTC INFORMATION FOR SEQ ID SEQUENCE CHARACTERISTICS: LENGTH: 666 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular AM~ENDED SH-'iI POUS 9 6I/O9Iz2a IfENUS 18 DEC01996 142 (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .666 (xi) SEQUENCE DESCRIPTION: SEQ ID
ATGAAGAAAA
GCGGTC'TT
AAACAAAACC
ATAACCGCCT
GTGCG'FrATG
GGCGAGGGCT
ATCAITI'1CC
GCTAGCGGGA
GACAACCCCA
T TGTCAATGT ATTT1'CATGT
TCCMAC
AAGCAAAAGT
TTTGTGAG
ATAAGATT
CAGGGAATGC
ACACCAAGAC
TGCTCGTTAA
CCITITTATGT
AGGATCAAAA
TI'GGCATGT
GGAATCCTAA
CCACGAGCAA
CTTTTGGTGT
CGTATCAGAC
TGAAATCCTT
GATCCTAI'G
TAAAGAAGCG
AACCGATTAT
CCAAGACAGC
ATATAAGATT
CAATGCGACT
GATI'TATGTC
TAAAAGAACT
TGTITTAAAA
GCTAAAGAAA
GCGGATAAAG
AATTATGACG
TTATI'AGAAG
GTGAAA'ITGA
GTGAGCGGGA
AAAAACATGA
TCAGGCTCAT
GGCGATATTC
ACCGGGTT
TGA'rTCGTTG
TCGCTATGCA
TGAGCGCCAA
1I.3TATATTCT
GCAATATTAA
GTTI'GAACGA
T'TGGGTGAG
GCGCTTCAGG
'ITAACATGCA
CTGTATTGTA
TATACCCTGA
G?1'GTATITG
ACGATTTGAC
AGACAATGTG
AGCGG RTAAG GGT1'TATAGG
AAAATATGAG
CGCGGATAT
GTGCAGCATr
AAAATCGCAT
TI'TGCCCTAT
GTTTGGCACT
INFORMATION FOR SEQ ID NO:46: SEQUENCE CHARACTERISTICS: LENGTH: 159 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .159 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:46
ATGCTGGATI'
ITI'GTTI'CGC
TCGCATCGGG
TTGATTTGGT TCITIrTTGGC GCGACTGGGG ATrAGCCAT GCGAAACCTC TTT ATGAAAT ?I'ATAITCA ITTATGGTI'r TAAAAACGAT TCTAGGATTA GCGTAAGGAG CTATCCAATG AAGAG'Trr INFORMATION FOR SEQ ID NO:47: SEQUENCE CHARACTERISTICS: LENGTH: 327 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular AMENDED SHL Pr^ 96/09122 IPENUS 1 8 DC 1996 143 (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...327 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:47 ATGCAAGATT TACCCCCATG CCCTAAACGC AACGACGCCT ACACCTACCA TGATGGCACG CAGTTCGTTT GCTCTAGCTG TTTGTATGAA TGGAATGGAA ATGAAATTAG TAATGAAGAA 120 TTGATCGTTA AAGATTGCCA TAATAATCTT TTACAAAATG GGGACTCGGT CATTCTCATT 180 AAAGATTTAA AGGTTAAAGG CTCATCTTTG GTGCTTAAAA AAGGCACTAA AATCAAAAAT 240 ATCAAGCTTG TCAATAGCGA TCACAATGTG GATTGTAAAG TGGAAGGGCA GAGCTTGTCT 300 TTAAAATCTG AATTCCTTAA AAAAGCT 327 INFORMATION FOR SEQ ID NO:48: SEQUENCE CHARACTERISTICS: LENGTH: 219 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY:'circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...219 (xi).SEQUENCE DESCRIPTION: SEQ ID NO:48 GTGGATGGGG CTATCATAAC AGGGAATTAT GCCTTGCAAG CAAAACTCAC CGGAGCCTTA TTTCAGAAG ATAAGGACTC GCCTTATGCT AATCTTGTAG CCTCTCGTGA GGATAATGCG 120 CAAGATGAAG CGATAAAAGC GTTGATTGAA GCCTTACAGA GCGAAAAGAC CAGGAAATTC 180 ATTTTGGATA CCTATAAGGG GGCGATTATC CCGGCTTTT 219 INFORMATION FOR SEQ ID NO:49: SEQUENCE CHARACTERISTICS: LENGTH: 711 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
i (iv) ANTI-SENSE: NO A k Cklcn OUCCT .9 II ;1f" IPENS 1iBDEC 1996 (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .711 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:49 GTGT1TTYCCA
GAAGGGGTGG
AATAACGCTT
GGGATTlATTT
CTCAATAACG
ATGGGGAAGA
ACCCCTGTAT
ATCAGAGCCA
GGAGCGTTTG
ATCGTGGSYT
GGCTTATGCG
CFI'AGGCTCA
TGCTGGTGTT
GGCTATGCTC
CTATI'GAAGC
TGATCT G CCGA?1 9
ATTC
GTGCTCAATT
CCGCTCTCAT
ATCCTTI'GTA
TGGCTCTITTT
AT1'CCACGCT
ATCGCGCTT
GGCAATGTCA
GGTGTTGAGC
'rTACT'rGCTC CT1'TGTGATG
GAATTTTGGC
CATGCTCTT
CCCTATGCAC
CCATGCARCG
TAGTGCGGTG
TGGAGCGAGC
TTCTCAATTA
TCCACCTCTI'
TGCAT GCGAT
GATAATTIT
ATTGGCTT
AATCGAATCA
ACCCTCCAGT
TACAI'AGCG
ACATGGTTAG
ACGATGGTAA
TTTGAAGTGG
ATGGCTFI'AG
GGGCTATATG
TACGCATGCG
GGAAGACAAT
TAGGGCTlTr
GGTATCATAA
CGGATITAGG
ATAAAGAAGT
TGIT TTTl
CCAACGCTAT
CCGCTGGGGT
G'FTATTrAT
TCAATAAGGA
'TTTGTAGCGG
ITC'ITCAAAT
CTGGATATTA
CATGGCTGG
AAAAAGCGCG
CATGCTCATG
CTTTAGCATG
TATTGGCGCT
GGAGGGGCCT
GTATCTAATC
CGCATGCTI'A
TTTAAAACGC
CCGGGCTTGG
CCCTCCTIWIT
C
INFORMATION FOR SEQ ID SEQUENCE CHARACTERISTICS: LENGTH: 291 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .291 (xi) SEQUENCE DESCRIPTION: SEQ ID
ATGATGATAA
CTTTCGGCGT
GCGAAAAGCT
GTGGTGTCTC
TTATI'GCTrT
CCAAACAATC
'rrATITIAA
TTGAAATGGA
TIGGCTCAT
TTC'rITrCGC
GTATCAAAGA
CACCACGGAG
GAGCGCAACA
GCCCTTGATG
TCTI=TAT1
TTCGCITAA
TTTGTCCCTG
GTGGGGC'ITA
CTGCTTIAGCG
TI!CAGCCATA
TGCGGGrTi'l
TTGCACTTCT
TGATCACTGC
CTAAAAMTGA
TCCTTCGCG
TGTGTI'TTCG
GTCAGACATT
TTATGCATGG
AAGGAAACGC
T
INFORMATION FOR SEQ ID NO:51: SEQUENCE CHARACTERISTICS: LENGTH: 840 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular I, >0 N (ii) (iii) MOLECULE TYPE: DNA (genomic) HYPOTHETICAL: NO A&acmncn CUI~rT PCT"Z 9 6/0912 1 P EAUS3 1 c- n EC019896 (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .840 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:51
ATGAAACTGA
TGCAGTAACT
AATGAACTG3A
TI'CATGGTGC
GTACTAACTT
AAGATCCTCC
TACTTGCAAC
AATCCCAACA
CTAGGAGCTA
GTGATCAATG
ACTCTCTI'GC
TTAGAAACAT
AT'IWIAAGA
CAAGAAGAAA
GAGCAAGTGT
ATGCGAAAAA
TAGAGAAGTA
AAGTGAAGTI'
TCAAACTI'GT
AATACAAGAA
CCACTGAA
ACAAAGAAAA
ACACAAAAAA
AAGTGGCAAG
AAGACAAGGA
TGAGTAATCG
ATGGCAACTI'
GAGAGAATGA
TTTAATCGGT
AGTGGTGAAA
TAGTGAGATC
GCCAAATTAC
TCACCA'ITCT
'ITACTI'CCAA
TCAAAAGGGT
ACCACAGACC
CTTGCATGGC
AGAAAAAGCT
ACAAGAATAT
TGCAGGTTAT
GAACATGCAA
ATACTI'GCGC
GTGGCAATC
CAAAAGAACC
CCCTTAAATG
AAGGACTATT1
AAAAAGATTA
GCTAACGGGG
GTGGTGATGA
TTTGATGTGT
TATGATGTGA
CAGCTAGAAA
ACCACTAGGA
CAAATGAGGC
GCCAAAGAAG
AATCAAATCA
TGTGCTTAAT
ATGTITATAC
ACAAACTCAA
TGTI'GGATAA
CGCTCATAGG
CAAGATCTGA
TAGCGAGTAA
TGCAAGGAAG
GTGGAGCAAA
AAATCAATCA
AAAATAACCA
AGAATGTGAT
AAGAAGTTAG
GAAGTTTGCT
TTI'AAGTGCG
GCCTGTGTAT
AGACACACCA
TAAACAAGTI'
CGATGCCAAT
CATTGATTT
CTACAATGAT
TCAGCCAATG
CAACAAGCAA
GTATTACAAG
ACGAGAAATTI
TAGTTCTGAG
GGAGAAGCTA
CAGTGGTAAG
120 180 240 300 360 420 480 540 600 660 720 780 840 INFORMATION FOR SEQ ID NO:S2: SEQUENCE CHARACTERISTICS: LENGTH: 174 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .174 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:52 ATGTGGrI'AG ATCACATCGC TAAAGAGATC AGAAGTAG TGGAAAACGA TATTGAAGTG GGTATTGTGA TTGGTGGAGG CAATATCAT AGGGGGGTTA GCGCGGCTCT AGGGGGGATC AI'AGGCGCA CCAGTGGGGA ?I'ATATGGGC ATGTTAGCCA CCGTGATTAW GCGG INFORMATION FOR SEQ ID NO:53: SEQUENCE CHARACTERISTICS: LENGTH: 372 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) I P SS6/0912.2 I8 DEC 1996 146 (iii) HYISOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1 .372 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:53
GTGCATAACT
GAAGAAATT
TTAGGACACC
GAAACTAAAA
CACCTAGAAA
ACCGTAACTT
GCCCAFI'TAG
TCCATI'GGAA
ATGAAGGGTI'
ACCCCCTAGT
CGAGCTI'CCA
AAGAAT'ITAA
ATGCGGACGA
CT
TGTGAAAGGC
TGCGGACATG
CACTITATCC
CTCTAAAGAC
AGAGCTCTCT
TCAATTAGCC
ACCGATIT
TIGATGATC
GAAGCGATCA
ATCTITrAAAG
AACACCGCCG
AAGTTGCAAA
TCAATGTGCA
TCGCTGAAAG
AACTCACTCG
AAA'ITCTAGA
AAAAAGAAGG
AATCCATTTG
TAAAGCCACT
GATCGTICAA
TGTTAAAGAAV
GGACTACAAA
CGATAAAG'T
GATGCTAGAA
120 180 240 300 360 372 INFORMATION FOR SEQ ID NO:54: SEQUENCE CHARACTERISTICS: LENGTH: 270 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .270 (xi).SEQUENCE DESCRIPTION: SEQ ID NO:54 ATGAATAAAA 'CCATAAAAGC AAAGTGATCG CAAGCGGGGT TACGATATAG CGCTCTTC GACTGCGCGA TACCTGAAGA AGCGTGGAAA ATAACGCGCA CGCCGCCCTA GCCTATAACA GGGCGAAGTG GCTAAAAGGA TAACCCCATG CTGGTGGAI' ATI'GTATGAA AGCGTGGTGC
AATGTCCAAG
TGGGGCAAGA
TCATTCAAAA
CGCTCTTAAA
AAGTG TTr
TCATGCCCCA
AGCTAAGGAA
GGTGGAATTA
ATGGCTCAAC
INFORMATION FOR SEQ ID SEQUENCE CHARACTERISTICS: LENGTH: 633 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO I'K~7 AMFNrlFfl eWPPT POUS 96/091U IPENIJS 1 8CO1996 (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc -feature LOCATION .633 (xi) SEQUENCE DESCRIPTION: SEQ ID
ATGGGGAAAA
CTTTTAGCT'
TTGCAAAAAG
GGCA'ITCAAG
GCCCTAAACT
GAAGGGTTI'
AFI'GATGCGA
ATrCAAAATG
AGCGCTTTAT
CTGTCTI'GC
AAAACCTI'G
TI'TCAGCGCA
CGGTGTTATT
C TTATGGCG
CCAACCGCAC
GCTACACTI'A
TrGACTTTGA
?I'GAAGCCTI'
AATTATTGT
TGAGCC'FIT
AAGTCGTTAA
AAATTAAGAT
TTI'AGCC CAT
AAAGCATGCG
CGTAGAAAGG
CAAGCAAAGT
CTCTAAAGAC
TrTAATGGGG
AGAAGAGAGC
CTTCACCATT
TGAAACCACT
AGCCCATGAA
TCTTAACGCT
GAAATCAGAA
AACGAAAAAA
ATCATI'AAAG
TI'GAAAACGC
ATTGATTIT'C
AT1'GTGITAC
GAACAAGGTC
ATTGATAATG
AAATTAAAGG
GGGAGCATTG
TCT
ACCCCGTAGG
CTAAACCCAT
CCACCTI'GCT
TAGAGAGCGA
T'vrrAA=I
AAAATI'CT'
AGGTCAAAAT
GCAAGGAAGT
GGAATGGCI'
CGCTATTAGA
CTCTATCTCT
TGTI'GTAGAA
ITTTTCTAAA
TCTCAAAGAA
TAGCGATGAA
GTATAACGCC
TGAAGCGTTC
GGAAAATAAA
AGGGTI'AGCC
AAATCAAGAA
120 180 240 300 360 420 480 540 600 633 INFORMATION FOR SEQ ID NO:56: SEQUENCE CHARACTERISTICS: LENGTH: 636 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc-feature LOCATION .636 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:56
GTGTCAGAAT
GCCI'TATTGC
ACAGCGGCCT
CCTGTI'AGCA
GCI'GGATCA
GAAATCTTAA
ATrGGCTTI'r
ATCACAGCGG
TGATCGCTA
GCGAGCGCGG
TTGTGAGCT
TrCATCAAGT CGATIT1TG TTrIGAGCGT
TGGTGGGTI'C
T1'ATI'GCCGC
AAGAAAGCGT
GTITI'CGCTC
CGATI'TTAGT
ACACCGCTCC
TAGGGGTGCC
TGTTAGTGCC
TTATGACCCT TIGGGTAATA ATTrITCTTA TCTTTAATGG GGCCTI'ATCA GCCATrAI'G AAGCT'CCT' TATGGCTITC GAT'IIIA TACAAACTCA TCAGTCCATC ACTTTAGATC ATITAGAA GGGGCGATCG GGGGTTGGGG TTAAGCCCT' TGTGGCCTIT GGCGCGGTGG, AGCGATC ITA ATTI'CAGCCA GTrITTT GTGTKT
TTI'GGCTGAG
TTTAAACT
CGGTITrAGT
TTTIATGGCCT
GCGTTAAATC
ACCGCATTTT
GCTIGGAGG,
TGTATTCTGC
GTATCCCTAT
TGACGGGTAA
CGCTCTI'GTG
CAAAGGTTAT
GTATAAAATG
ATGGCTATTC
CGGCTATT
AGTGATTTTG
GCCTATI'GCC
TGGGTI'ATGT
AAGCGCGATG
AATCCTCTT
120 180 240 300 360 420 480 540 600 636 INFORMATION FOR SEQ ID NO:57: SEQUENCE CHARACTERISTICS: LENGTH: 546 base pairs TYPE: nucleic acid d. PC '169 91 ~PEJUS 5" 8K 9 6 STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .546 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:57 ATGGAAATrA
ATCGCTGAAA
ATCAATCGT
AAAAATAAGA
AAAAATAAGG
ATrGTGGAAT
CCTGAAGTCA
GAAGAATTGC
GCAAACCCCA
ATTTTT
AAATGGCTAA
AAAATCAAAA
TGGAAAAAAA
GCGTGATCAT
GGGTTAAAAT
CCATGAGTAA
AGGGCGTGAT
AAGAAAAAAA
AA.ACTCTTGC
GGATI'ATGGT
CAGCTTGATT
TI'CAATGTG
AAGAACCCAT
CACTGACGCG
AGAAGGGTAT
CAGCTATGCC
ATTGCAACGG
AAATCGCTTC
TTTTGTTTG
TI'GGCTCGC
AAAATI'GAAG
GGCATI'CCTA
ACTI'GCCCGT
CAAATCGTGC
ACTAACCAGG
AAAGTGGCT
TTATIGGTG
GCGTCAAAAG
TCATTCATAA
AAGATCCTAA
AACAGGATTI'
ATGTGATCAA
ITTITTGGGGA
C'ITTAGTCGG
TAGTCTCTCA
GARGRTGCAC
AGCGATACAA
CGCTAAAGAA
AAAAATCCCT
AGAATACTTG
ACCTCAGCAA
CATTAACCAC
CAATTCGT'A
AACCACCCAA
TGAAGTGCGT
INFORMATION FOR SEQ ID NO:58: SEQUENCE CHARACTERISTICS: LENGTH: 672 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .672 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:58 ATGGATCATG AGTITITIGAT CTTAITFTAC TCCCTATAGG 'ITAACGAGCT TAACAGAAAC GGGTrTTATC TTCTTTTAAT GTG2TTAAATG TGAAACTCGT TCCTI'GCCCT 'ITATGGTAAG AAAGAAGCCA GTI'ATAGCTT CCTAACATCA AACCCAGTGT GAAI'TGGCG TGGTGATGAT ATTACGATCT TTAACGAAGC ACGCTCACGC TTAITAGTTT AGCTCGTIT TA
TACCATGCGT
GA'TTITI'A
GCTIGTGTAT
CTITI'CGCCT
rTTAGTTTC
CCCTATTAAA
GGGTAAAGGG
GTTGATGGCT
GCTTGGGGGT
TGAAGCACTC
TAGCCTCTTG
TGAGCTIWIT
GGCTATITTT
ATGCCTT'IAG
TCTCTI'IT1
CAAGGGCTTA
AGCGCGI'AA
GAATACTACA
ATCATTACAA
GATATATTAG
AA?1'ATTCTA
TTGTTACCC
C'ITTAGCT
TAAGCCT'AA
TTTTACCCCC
TGGGAGCGTT
TCTTAGGGAG
TTTCC?1'GCC cccirrITI
CTI'TTATGCA
GGGAAACAAG
AAGCCCATCA
TATTTTAAA
GATTACCACC
ACGCAATCT'
AAGCGTGCTA
TTrACAAGAT
CGTGATT
CACTI'C'TA
TGTCCTACTC
CACTATAGGT
AGTGGCTAGC
ATACGCCT'A
TAAAAAACAA
X,7 A #AN ?I I" POT/US 96/09122 IPEIVIJS 18 D E C19 96 1.49 INFORMATION FOR SEQ ID NO:59: SEQUENCE CHARACTERISTICS: LENGTH: 420 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc-feature LOCATION .420 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:59
ATGCATCCTA
GGAACACTT
GCAAAGAGT'
GAATTAATAG
GACATGAGAG
GAAATI'GATTI
ATAGAAAAAT
TAATG ITTGC
GCATGGCGTI
TGATAGGCAA
AATGTGGCGT
CCAGACAAGT
TAAAAAAGAT
CCTCAATGAT
CTATATCGCT
TCAAAAAATA
CCTITCTCAA
CCCATI'AAGC
GCTAGTAAAA
TTGCAAGAAC
CTTAAAAAAG
AACGCGCTCG
TCTCAAGTCA
GTGATTATCT
GATAGTGAAA
AATATCGTTA
TACTITATAT
CAAACCAAGA
CTCAAGCTAG
AAGAATTAGG
ACCCCACAAA
TCAATITCI'
CAAACGCTI'C
TC ITGATAGC
AACTI'ATAAG
AAAGATCAAC
CATTGATAAA
AGATACTGAT
ACACAACACG
AGCTITTTAT
AATGCTGGTA
GAAGAGTAT'
INFORMATION FOR SEQ ID SEQUENCE CHARACTERISTICS: LENGTH: 219 base pairs.
TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii).HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc-feature LOCATION .219 (xi) SEQUENCE DESCRIPTION: SEQ ID ATGTGCCTGA CAGOCCOCTI' GATGCGTTGG CTCAAATCGG CATI'CTGTGG TGGAAT'TTGT GGATA'ITGCC GGAITGATI'A GGTTTAGGCA ATCAGTTI"IT AGCCAATATC AAGGAATGCG CGCTGTTTG AAGATGACAA TYATCACGCA TGTGAACGA eINFORMATION FOR SEQ ID NO:61: TAAAGCCTGA ACGAATCTTG AGGGGGCGAG CAAJGGGGGAG AAGTGATCTT GCAAGTGGTG A~AfI.,nrf~ ~tA~T 96/0912 I1PEN1JS 18 Dr,c 19 96 150 SEQUJENCE CHARACTERISTICS: LENGTH: 276 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1. 276 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:61
ATGCATGTTG
GAAATCGCT
ATCGCCAAGC
CCTGCTTT
TTATTAAAGC
CTTGTCTT
CCAAACAGCA
TTTTAGAATG
ATGACCTI'AA
AATTAAAAAA
GGC TITAGGG GATAACCTCA ACAGTCCCIT AAAATCCTAG CGAAAAACAT T1'GAAATCA AAAACAAGGC G 'FI'TTGGG CATCAAATCA AACGI'
TCACGCTTAG
GCACTCKTI'
TCCTGTTIT
CP3ATGAAGGA
CCITTTAAA.A
GACTTTAAAA
TGAAAATATC
TTI'ATGG
INFORMATION FOR SEQ ID NO:62: SEQUENCE CHARACTERISTICS: LENGTH: 615 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) 'FEATURE: NAME/KEY: misc-feature LOCATION 1 615 (xi) SEQUENCE DESCRIPTION: SEQ ID, NO:62
ATGAAAAAGA
AAGAGAGAGA
TTCACACACA
GACGAAGAAT
rIICATTTA
AAAAAATGCC
GTTAAGATTC
GCATCAGGCG
ATCGCACCCA
GATAAATCTG
AGCCATTGAT
GAGAGTTAI'
CTCAAGCCGA
GGGGGTTTAA
GGGOGGTTGAA
TTTCAGACGC
AAGAAAGAAA
CTGCAGGAGT
TTCAAGCAGG
TGGGCGCGAG
GTGGCGTATC
AAGCTI'CGCT
AGCCGGCGAT
AGGTTI'GTC
AGTCCCTGT1'
TGAAAAAAAT
ACAGGCTATG
TGCTGGGCT
GATOATCTAT
TTTGGTCGCA
TGTGCGTI'AA
AAACATI'GGA
GCGTTTGTCC
AGAGCCTATG
GAAGGTTAG
AAGAAAAGGC
ATAGAGGAAT
ATCCCCATAC
AAAATGAATG
GGA?1'GTI'AG
GGAGACTTCT
ATATCCCAAC
AAGAAACTAA
TGAGGGTCAA
AAGAATTGGT
A TI'CTI'GAG
GTAAAACCAT
CTiTiAGCGA
ACGCITTTGG
GCGTAAACTG
TCTAGGGTC
GAI'TGTCGI'
AGGGATCATA.
TITCCGTI'GCC
AGATGAAACG
TATTCAAAGA
TATCCATG IT
TGCGCTCGCT
AATGGATTI'G
TCGCGCAAGT
GGGGAGGACT CTCGT 'If '(INFORMATION FOR SEQ ID NO:63: /7
K
PCTUS 9 61/09122 [PEANS 18 D EC1996 151 SEQUENCE CHARACTERISTICS: LENGTH: 123 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .123 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:63 GTGCTTGGCG TGTTYAATIT AAGGGGCAAT GTC ITCCCTT TGATCAG ITT GCGITTAAAG TI'GGCTrGA AAGCCGAAAA ACAAAACAAA GACACTCGTI' AITTGGTGGT ACGCCATAAC
GAT
INFORMATION FOR SEQ ID NO:64: SEQUENCE CHARACTERISTICS: LENGTH: 657 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix).FEATURE: NAME/KEY: misc-feature LOCATION .657 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:64
GTGAAAAGCG
TI'GATCGCTI'
ACGATTATAG
GTGGT1'TrT
'ITTTATCAAA
ATCGCTAGCG
IT'IIGCAG
GTGTIGGTTA
GAAGTCTFI'C
AAGGGGGTTA
TGCTAFFI'AG
TTTTTAGCGA
ATGACCCCCT
GGGTrI'ATGA
GGCATAAAAT
ACAAGTTTCA
GAGGCAATCA
AAAATTACCG
AAAAGGGCGG
CTTTAGCCTT
AAAAGCGTTT
CCAGCCCGCA
AGAAAAAGAA
AGATGGGAGT
AAAGGATTAT
AGAATTGGTG
TTrATAGAA
AAAGGATTT'
CTI'GCGATAC
AATGTTTTCC
GATGGTTGAA
GCTAGATCAA
TGAAGCTCAG
ACGCCTGTTA
TCAGTGATGG
AAGGCGCAAA
GTGGCTTTAG
ACCATCGTT
TCYTTGGGCT
TCAGGATCTA
TACCCGCAAA
AAAGCTAAAG
AGCGTAGAAA
ATTI'TAGAAA
CTAAAGAAAA
AGGCGAAITr AT1'rAGTTGC
AAGAAGTITA
TAGAAAATAA
TAAAAAAGGC
TGGTGGCTG3A
AGAAATTGCG
GGGAAGCG IT
GCTACCATGA
AACA'ITTAAA
CGGCTCTTAT
CTI'AGTAGGC
AAGCCTITAT
TCGTTACGCT
GGGTAAAATC
TTTAGAAGGG
TGTCCATCAT
AAAGCTITITT
TTATTTTGAT
AAAAAGCGAA
GGGAGAA
INFORMATION FOR SEQ ID POUS 9 6f/091 2a fPEMS 18BDEC 1996 152 SEQUENCE CHARACTERISTICS: LENGTH: 564 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .564 (xi) SEQUENCE DESCRIPTION: SEQ ID
ATGAAAAGCA
GCGTTATGCT
GCGATAAAAA
TTCAGGTI'GG
TTATCTCAAA
GACGCCAAAA
AAA.ATCAAAG
AATTTACAAA
CTCACGCTTA
AAGAAAAACA
TI'GGAGAAGT
C TTTGGAAAA
AGGAAATCCG
GCGTI'TCTGT
TI'CAAAAACT
AATI'GAGAGG
AAAATGAAAA
TCGCGCCCCA
'FITGTATI'CC
AGAAAAGAAA
GATGGCGATA
CAA'DTGGCTA
CCGGCCCAAT
GGATGAAGTG
AGTCAAAGCA
GCTTAAAAAT
T1'TAGAGGTC rrITrGAAGAA
ACCTATGCCC
ATCC
GGGGGCAAT
GGGTTTGAAT
CCCAAACGCT
TTrGAATrAT
GAAGAGGGCA
TTAGGCTITA
AGCCCTTTG
GTGGACACTI'
CTAACCCTIT
TCTTAGAAGC
CGTI'AAGCAA
TGCTCTATAT
GCCAGAI'GA
TCAATTCTAG
GCGATGCCAG
AAGTGGAAT'
GCGCGGCGGA
GCCCCCTATI'
CTTACAAAAA
AGATTTAGAG
TGCTGATGCG
CAGGTGGTTT
CGTTTTAACG
GATTGCCACT
AGCTAGATCT
GT TTTITATCG
GGAAACAAAC
120 180 240 300 360 420 480 540 564 INFORMATION FOR SEQ ID NO:66: SEQUENCE CHARACTERISTICS: LENGTH: 693 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .693 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:66
ATGTTTGGGA
TTAAAAAAAG
GTAGGTATTA
TAGAAGAAC
TCTTA'rTCTr
'ACAGGGGGTG
'-A.AAGAGGGCT
6CT-GAATG
AAAACGGGTC
ATAAGCAGTT
AAGTCAATCT
AAAACAATAA
AAAGCGTTCA
TGAAAAGCCA
TGGGGGAATA
TAGAGAACGC
CGGCTAAAAA
AAGACATTGA
ACAGCTI'CAA
CTATCAAAGC
AGTCGTTTT
TTITAAAGAA
AXATATI'GAC
CCATAAAAAT
GCAAGAPLAGC
TGGCGAAGAG
ATCGCTTTAT
ATCAGTCAAA
CTTTTAAAT'
AAAAGCGGGA
AACGCAGAAA
GGCGTGCAGT
GA TTTG'FITA
ATGCAGTATT
CATICTAATG
GAAAAGATGC
AAGAI'CTGA
TGTGCTI'GCA
ATCTI'GCAAG
GCGTTAATTT
ATTrTCAT AGACTTrTG
TCCATCAAGA
AAGGATI'AAT
AAAACGCCAC
GATTGCGGAG
TGAGGGTTTIT
CTTAAACAAT
ACAAGGGGT'r
GGCTAAAAAA
CACGAGCTTA
AACAGGCTI'G
AACCGTIAAT
TTCG'ITAGCG
120 180 240 300 360 420 480 540 ~AFNOED ~NF~-1 PCTIUS 9 6 /09 12 2 IPEAIJS 18 D t"C 19'9 GACTCCCTCA ACCAACGGAG CAATGAAATC ACTCAAGTCA Fr'TCrTTGAT GCAGAGCAAA CCAATCTCTI' AGCCCTAAAC GCCGCTATI'G AGGCCGCACG ATGGCAGAGG GTrI'GCGGTG GTGGCTGATG AGG
TGATGATAT
AGCGGTIGAAC
INFORMATION FOR SEQ ID NO:67: SEQUENCE CHARACTERISTICS: LENGTH: 189 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .189 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:67 ATGTGGATTA TGTCTTCACT TrCTAGTTCA TTCITTCATT CGCTCI'CTr CATCAAATCA AACCCTGGCC AACTCITAAA AGGTI GGGGT TCAAAAATCT 'TrTCATAAA. TAGAAAGTT GFFIIAGCAC AGTATAATCC TAGCGTrTCA ATITTIWFT TACTCAATAG GGTGTT TGGT
GFI'GGCGTI
INFORMATION FOR SEQ ID NO:68: SEQUENCE CHARACTERISTICS: LENGTH: 459 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: No (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .459 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:68 120 180 189
GTGGGCGCTA
GAGAAAGGGA
CTCAATGACG
AAWI'TGGACA
TTTTIATTCTC
CCAAATGATC
GCTCTCAAAG
,AACATCAAAA
ACCCTGTGCC
TCAAATTAGT
GCTCTTTAGA
GAAAAATGCA
AAAAAATCAC
CGGCCAATCA
ACCCAAGCAA
TCAAACCCCT
GCATGCGCAA
GATCGTGTCT
CGCGAAT'AC
CCTTGTTGGT
AGACAITAAA
AGGCAGGGCG
TCTATACGCT
AGAAGCTGCG
ATCTTGCAAT
TTTACGGATT
TCCAGCACC
TTGGCCAATA
AACCTTIAAAA
ITGAITTTAC
ACGGAGITTG
GTTATTGCC
CAGTTGTGGA.
ATGTGTTGCC
GCCCT'AITI
TCCATGTGGA
AAGGCTCAGT
TCCATAAACA
ATAITGTCAA
TGXTGAAA
TAAITTAGCG
GGATCGGTT
GCCTI'AAGA
GATTGCTGTG
AGGCCTTATC
AAATCCTTrAC 120 180 240 300 360 420 459 PCTIU 96/09122 "PNS 18 DEt.19b 154 INFORMATION FOR SEQ ID NO:69: SEQUENCE CHARACTERISTICS: LENGTH: 216 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc_feature LOCATION .216 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:69 ATGGGGCTTG TTGCGAGCGG CATI'AACGAT GAAGAGCT'IT TAAAATGGCT TCAGGC'T GGGTTAAAAA TGGGTCI'TG TIT CAAGTG CTAGATGATA TrATAGACGT TACACAAGAT GAAAAAGAAA GCGGTAAAAC CACGCA'FrTA GACAGCGCTA AAA.ACAGCTI' TGTGAATI'TA I-rGGGGCTAA AAAAGGCAGC GGTTACGCCC AAACTT INFORMATION FOR SEQ ID Wi SEQUENCE CHARACTERISTICS: LENGTH: 627 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KFX: misc-feature LOCATION .627 (xi) SEQUENCE DESCRIPTION: SEQ ID
ATGGGGTI'IA
CGCCCGAGCG
GCTCTTITGT
CCTTTITIAA
rTrGTCGTGG
GATATI'CCTT
GATTTGCTCT
CCTAGCCAAT
CTGATCTGCT
TTAGGGG TI'
AACATITCCTA
ACCGCTI'GGT
TGGATGGTAG
TCGTGGGAGT
TCA'FITTAGG
GTI'GGCTr
TATGGAATGT
ATTC TTACA
TAGGGGAAAA.
GGCTTTGTIT
CAGCCI'GAT
AAGCCTTT
GGATAGAGAC
GATCAGCGTT
GAGI'ATr1'C GGGTTATrCG
GGGTTTAGCC
CT TITGGCY
GGATATGGAG
ATGGTGCI'G
TGTGAAATGC
CTTACTCTAT
1'TGTGAG
ATTGATAAGG
AAAGGCATGG
ATCAACCCTT
TATITCAAGC
CCCA'ITGCAG
TTAGGGGTGA
TTTGATAAAG
AATCTTTCAA
TATCATGGGG
GAGCAGATTT
ATAACCCAAG
TCATTITAG
TAGCTTI'CAA
GC Ti rr CTTC
GAAGCGTGGC
TGTTGTGGGT
AAAGGGGCTI'
GGCTCTCGCA
GGCT'I'TFIC
TAGTGGCCAG
GACGAAAAAC
CGTTTCAPAAC
GCTTTCGTITA
TTGKGCGCAT
GGT 'rTAGGG
GGCTGGGTTT
GTTTTCCATT~
CCTI'GTGGCA
GTATTI GG C
AGATTATAAA
120 180 240 300 360 420 480 540 600 627 rr rr 1 PC~ %091 a 1PENUS 18D E C 1996 155 INFORMATION FOR SEQ ID NO:71: SEQUENCE CHARACTERISTICS: LENGTH: 285 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .285 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:71
GTGGAGCAAA
ACATTGATTG
TACGGGTATC
TTCAAAAAGA
TCI=CTACA
ATAAAATCAT
GCACGAITTWA
TITITIGCGCT
AAGGGITGGT
CCGCATGGCA
TAAACTCITC
TGGCATGAAT
GA'ITGTCATG
TGTAGCCTTT
TAGTCTCCT
ACTGTGGCGA
TITAAATTCA
GCGAITI'CTA
CATGGAATTI
GGCTACGCCA
CTATGGCGAT
TGCCGGAG1T
CGATTI'GCC
TTATCCTCAC
CGCT
GATGCCCCCC
AGAATGGCA.A
GGTGATIAT
TCTTAGACGC
INFORMATION FOR SEQ ID NO:72: SEQUENCE CHARACTERISTICS: LENGTH: 276 base ,.r TYPE: nucleic acit STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv).ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .276 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:72
ATGTITCGAT
G'TI'GGATT
TTAAAGATI'G
GACGCTCCAG
AATGAATTGT
CAATCGTITA
CGCTTI'ATIT
AACTCAGGCG
AGCATTTTAT
TGCAGGSCTT
TI'TTTCAAT
GGTGATGACT
CGAGATGCAA
GTITAATAAA
GGAAACACCA
AAGAGCGGGT
TTATGGGTCT
TCTTTGTCTA
AAAAGAAATG
GGTTCT
TTGTTACCAC
TTTTGTATAA.
ACATTCT1'AA
ATGAGACCAA
GC'ITGIITTA
AAGCAI"IGTA
TGGAGCGCAA
AAGGTA 'ICT 120 180 240 276 INFORMATION FOR SEQ ID NO:73: SEQUENCE CHARACTERISTICS: PCTW~ 96/O919 2 LENGTH: 375 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .375 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:73
ATGGCGATGC
GATATTGGCG
CTITI'AAAAA
GCGACCATCT
TTGAGCCAAC
AAAATGGGGT
TATAAACAAA
TYTATTGCAT
AATGGTTCCC
TCGTGTI'GGA
TrAGCGAAAT
TTTGGGTFT
TCATTGGCAA
AACTT
GCGGT1'KITG
TGATAATGAC
'I=CTCAA
CCCTAAAATC
AGAAAAATCT
ACAAGAAGGG
ATGCCGATT
CCCAAATACA
AGCAI'GGGT
ACTCCTTACA
CAAATCAGCT
CTGTTAGTCC
TAGGAGCGAT
AAAACGCCTC
TrGAATI'GCT
AACCGGCGAT
TGAAAGCCAC
AAGCGCATGT
TAAAGGGGGG
ITCTAAAGAG
TGAAATGGGA
'TTTAGAGAAT
TACAATGGAA
GAGCATGCGT
120 180 240 300 360 375 INFORMATION FOR SEQ ID NO:74: SEQUENCE CHARACTERISTICS: LENGTH: 3534 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc..feature LOCATION .3534 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:74
ATGATACCAA
CCACAAACCG
ATTAAAGTTG
AATGATAGGG
AATAAAGCGA
AGCAATGATr
CAGAAAITTG
CCGTCTAAAA
ATCTCTGATG
ATTATCATAG
TTGAAAGAGA
GATTGGCTTG
IGAAACGCTCA
ATTTAGATAT
AAGCGGCTIT
ATAATGTTGT
ATAATAGGCA
TCAAAAATCC
TAATCGACAA
GGACTCAGCG
TCAACACCCA
ATAAAGAGAA
GAAACCAAAT
GGCAAGAAGC
ATA'rTTT
ATCAAGAACC
AGAAGGAGAA
TAACCCGCAG
CGCITTCATTTI
AGCTTTTGAG
TACCAAAAAG
AGACAATCTC
'TACCAAATT
AAAAATCCGA
AGCGGAGTIT
CCGATCGGAT
AGAAAAAAAT
ATCAITGG
AGTTCCTCAT
ACAATGACTA
CAAI'TATCA
GATCCTAATC
AAAATCTCGC
AATCAGTAT'
AITGATACAG
TTTATGAArr
GGTTTI'ATGG
TTGAGGTCTG
CAAAAATI'CA
GGAGAGCCTA
TTTAACAAA
GTCCAACCAG
ACGAAGCCAT
ATAATC'ITCA
AAAAACCAAT
AGCTAAGGGA
TTTCAAGCT'
GTTCTTCCAT
GGGTGTCCCA
AAAATATCAT
CCAAACAAGC
TGGGCGTGTI'
ATGGAGATCC
AACAATCTIC
ATGTAGCCAC
TAACCAACAA
AGTGGC'TI'
CGTIGATAAG
GGAAI'CGCT
TATCAGTAAG
AAAGAGCTT
TCAAAACGAT
ACAACCCCCT
TTTGCAGGA
TGATGAATT
TACTGGTGG
CGATCTCAAA
TACCACCACT
120 180 240 300 360 420 480 540 600 660 720 780 POUS 9 6IO 91 Z a HiEWIS 18 DEC1996
GACATACAAA
AAATTCACTC
AA'ITACAAGT
AGTCATAATG
GAAGCTAGGC
GCTACACTCA
AAAGGGATTA
CGAGCAT1'GA
AATAATGCTA
GAAGATTC
TrTGTITCTA
TTGAGCTACA
AAA.ACCACTC
TTCAAATACA
TCCCATTI'AG
CTCGCTATCA
TCCCCACAAG
GGAAAAGCT
GAGGTGAAAC
AAAGATGTAG
TCTCAAGCTA
GATGCAAGAG
AAACTTGAAA
AATGGCAAAA
GTGAAAGATI'
TTGAATGAAT
GACCTTGAAA
AATCTCAATC
GCGFI'AGCCG
GA.AGATII'CA
GGAACCCTAG
TCGGACATCA
GGACTCGAAA
ATTGACCGAC
CTITIGAAAA
GAACCCATTI'
AAAGTTGATG
GACAATCTCA
ATGATAGACA
GCAAAAAAAG
ACACGCATTA
ACGCAAAAAA
GGAAGTGCTC
TATTCTGATT
GGCTTrGTGC
AGTGTGGAAC
GCTTACCCC
TI'GGCGATAT
TCAACCAATr
GCATAGAACC
ATGATTGGAA
TrAATGTGCA
ACAACCCTAG
GTCAAGAAGA
AATT1AGACAA
AAAAAGACTC
AAAAAGACAA
CTCTCAAAGA
'ITCAAGGTAG
CCAACGCCTC
AAGCAGGCTT
CTAGTGTCGT
AAGCTAATAA
TAAACTTCAA
AAGCTCAGAA
CGAAAAATT
ACAGCCAAAA
CAATCGCTI'A
ATATCAACAA
ATAAGGATI'
TAGGTATCAA
TCAAAAATGG
ATTCCATTAA
AAGCGGTATC
ATCTCAAAAA
ATACTGGAAA
TCGGTAATGG
AGAAAGAGTT
ACAGCACAGA
TCGATCAAAT
GGCATGATAA
ACGCTACGAT
ATCTCAGTAA
ACCAGGCGGT
AGCTCAAAGA
TGCCTACTAG
ATAGCAATGT
ATITCTGAGTG
CTGTCAGC
CGITCAAGTT
AA I=rTAAC
ATGGAGTCAA
TGAAGCTAGG
GAACATGT'A
ATI'GATCCAC
TGAAAAAGTI'
CGCCACCGTT
TATGAAAAAT
TTI'TATCTC
GATCCAAAAC
CTTGAGCAAG
TAAGGCTTAT
AAAACAT'ITA
TTATGGGAAA
ccTAAAACAT
CAAGAGTCCT
TAGCAAGGTA
AAGGCAGGAT
GCI'GTCAAA
TAAAGCTGTA
AGATCTTGAA
GGAGAGCAAA
AGATGAGATT
CGCTCAGAAT
GGATTTGAAA
CAGCAAGGCA
TCCAGAATGG
CAAAAATAAG
AGATGTGATC
AGTGGCTAAA
TITCTCAAAG
AAATTCTGCA
GTATCTAAA
GAATGCAAAA
ACCCATTTAT
AGCAAGTGGT
AGTI'GATGAT
TGATGATCTC
GGTAGGGCTT
ATCAGAAGCT
TrCTACAAAA
TTTGTCAGCG
CAAAAATGGA
GCTCAAGCTC
GTATGATAAA
TrCCACCAGG
CAATATATT'
AAATACTAAT
GATTTGCT'G
GATGTI'GAGG
AATAACGCTC
TCATI'GTTGT
GGTTATAAAA
GGCAGTGGGT
TACAAAGAAG
AAAGTGGAFr
AAAGAGAAAG
TI'AGACGCCC
GCTITrAGTIG
AAAGCAGATA
GATGGCGTGA
GATAAGGGTG
GCTGTCTITA
TTAGAGGATA
GATTrT1GA
GCTGAAGCTA
AAATCTCTAA
AGCGGCAACA
TTGCGTTGA
CTrAAAGGCA GACTrI'AGTA
GAAGAAACAC
AT'ICAAAAG
GATTI'CAGCA
ATCAATCAAA
GCAACGGGTG
GAGCAATIGG
CTATACCAAT
GCAGAAGCCA
CTTGGAAATr
ACTCAAGI'G
TTGGGTGAG
CTCAGTAAGG
GGCGGACCTT
TCAAGGGAGC
AAAGCAAGTC
AAGAATGTTG
AAA'rrGGACA
ACAATCAATG
GTGAATGATA
ATI'GGA I :CA
TTGAGCAATG
TCTATGGGAT
ACAAAAGGTG
ATGAAAGGGG
GAGTCGCTGA
TGTCTTCTGT
ATGGAAACAA
ACCAACGAGG
TAGTCATAGC
ACCAACTCAC
TCATGGAAT'
AAAAATI'CCA
TAGGGAATGA
CTGAGTI'TGG
AAGCTTTAGA
TGTTTGTrGA
TGGGTGCTAC
ATTTGCCTAA
AACTAATCGC
GCAGCAACAA
AAAACACAGG,
AGAAACGAGA
AAAATAAAAT
TCAATAAAGA
TCAAAAGGGA
AATCTTGA
TAAAAGCCCT
TrGAAAACCT
AGGTAACGCA
AGATAACGGA
AFI'TCAGTGG
CTCAACAAGC
CCGTI'AAGAA
CAACTCTITC
TCAATAACAA
CTAAAAAGGT
TAGGGCAAGC
TAGGGCTTTC
TCCC TI'GAA
AAAAATTGAC
AT1TTGACAA
TGAATCTATA
ATI'ACGCTAC
AAAAAGCGAC
AGATAGTTGC
ACCAAAAGAA
CCGTAAAAGA
CTrACAGCIT GTrTTCCAAAA TAXTT1'CT
CATTGATCCT
GTTAATGGGG
TGGTGGTCCT
CGACAATGTG
AGGTGGTGAG
AGGCTCACAA
TCTTGCACAA
AAATGAGAT
TCACATTGCT
TAATGGGGAA
TAGGGAGGCA
TTA'ITCTAAT
GAATGGCGTT
'TTAAATAAT
TAAAGGAT~
T
G
AGAAI'GGT'
CAACTATGAC
GCG1TITGGAG
GGAAGCAAAA
GGCTAATAGG
ATTGTCTGAT
TGAATTCAAA
TAAAGGCTCG
TAATGCAGCT
AGCAAAAAGC
TAAAGTTGAT
GGTAGAGCAA
TCAAAAAAAT
TGGTGTAAAC
TAAAAACT
TAACAATAAT
AAAAGCAAAA
AGCGAGCTTC
AGCTAACCAT
AAGGCATGAT
TCAGAAAAT'
CCTAGATCAA
TGTI'GAAAGT
TAACAGCCAC
CGGCATGCTA
GCATAATGTG
TATGAAAGAT
CATrAAGTCT
GATGAAAGCA
ATCT
840 900 960 1020 1080 1140 1200 1260 1320 1380 1440 1500 1560 1620 1680 1740 1800 1860 1920 1980 2040 2100 2160 2220 2280 2340 2400 2460 2520 2580 2640 2700 2760 2820 2880 2940 3000 3060 3120 3180 3240 3300 3360 3420 3480 3534 INFORMATION FOR SEQ ID SEQUENCE CHARACTERISTICS: LENGTH: 1398 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori PC r/bUs 9 6/O091 a2 fPENUS 18 SLJU'IJJ (ix) FEATURE: NAME/KEY: misc-feature LOCATION .1398 (xi) SEQUENCE DESCRIPTION: SEQ ID
ATGAAAGCGT
AACCACTTAA
GCTAAAAGAG
ATCAAGCTCG
GTGAATGATG
AATCCCATGC
GAA~AGGATCA
ATCTCTGAAA
AAAAACI'AC
AAGGATITTG
GGACTTAGAG
GCTAAAAAAA
ACGGCTTATG
GTGTATGCGA
GATAATGAGT
TGCAAGAAAG
CCTTAAAAG
AAAGGTGAAG
GTAGAAACTG
ATGGTGCAAA.
CCTGCTGACG
GAAATAGAGA
GGAAAGGCAA
CAGTCGTTTA
TGAAGACTI'
ACGCTGTGGC
CATGGGATGA
CTCAAGACAC
T'ITTGAACAA
AGTATGTAGA
AAGAAAATGC
AATGCCCTGA
ACCAAT'TT
CTAACGCCAT
GCAGAGCC'T
TCCAA
AAAAACTTAG
AAGTCAAACA
TGGGCG'ITAA
AAAACAGAAA
CGCAATTTGA
CAGCCGCTAA
CTrI'AGAAAT
TGCAAAGCTA
CCCTAAAAGA
AAGTCTATAG
GTGGCGTGAA
ATCCGTAT
TI-rAAAAAAA
TATGATI'GTG
AAGCAAGTGG
ATI'AGATAGG
AACCAATCAA
AAAAATCCAA
ACAAAACTAT
ACTCAATIGG
CACGAGCAAG
AGGTAACACT
ATTAGAATAC
AGACAGCCAA
AGCTGAAAAA
GCTI'GTTGTA
AACTTI'TGGG
TGGCAAA.AGC
TGAGCTTAAT
AGTGTTCAAT
CGCTCAAAAT
TGCATI'CAAG
TGACAAAGAG
GGCTAAAI'A
TTCAAATAGT
TCCCTIWFI'C
GATAATCCTA
GCTAAACAT
GCTAATCAGA
TITCTAACAG
AGTITI'GCCA
GATATACGCA
GATGTCAGTC
GGGAAAGAAA
CAAATCAGCA
ATTTGCATTC
ATGACTI'TAG
GAAGAATIAA
GCI'CCCAAG
TTCAACGATG
GAGTGCATCC
TI'AGAITATA.
GACTACAAAC
TAAGTITTA
CAACAAATGG
CATCAAGAAA
GACGCTTATG
AATAATGAAG
TGTTACTAGC
CGCAGAACGC
TAGCCACTAT
CGCTTAAT'C
GCAGTATTI'
AGCAAGTTICA
ATCAAATTGC
AAGACGCGAG
GCGCTAACAC
CGGCGAACGA
AAAAAGGCAA
CTCTACTCAA
AAAGACAAAT
ATAGAGCGTI'
AGAATGTI'AA
CTAACATGCT
GTAGGGATAT
ACCGATTCCA
TGAATAAGAC
GCTATTrGA
ATCITGAACA
GTTTCCCTAA.
CCCCAAGCTC
AATI'GCCITA
TI'GGAATGGT
TACTGAAAGG
CATCAACAAA
AAGCATCCCC
AGCCAATACT
AGCCAAACGC
CCCTACAGAG
AAAGGCTCTA
TT~TAGGAGCT
TTTAGAAGCG
TAACGACTAT-
CGCTTICAAAT
TAGTCAAATG
AAAAGGTTAT
CAATGTTAAT
TGCTGGTAAA
ACAATTAAGC
GCTAGGTITA
AGATATTATI'
AAAACAACAA
TGGTAGTGTA
TGATAATATC
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1140 1200 1260 1320 1380 1398 INFORMATION FOR SEQ ID NO:76: SEQUENCE CHARACTERISTICS: LENGTH: 189 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .189 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:76 GTGATGGATG CAGAAAATGG GGAATI'GCTC GTTGCAGGAA AACGATTTTG TAGGCGGGAT CAGTCAAGAC AAATGGCAAA AACCC AT TAAACCGC'IT CGCAATGCCT TGTATCCGCC
GCGTGGGGT
INFORMATION FOR SEQ ID NO:77: SEQUENCE CHARACTERISTICS: 1_1 LENGTH: 1263 base pairs GITACCCTGA ATACAArTrG AACTCCAAGA TGATATTTAT GGGATCTGTG G'rrAAAATGG 120 180 189 POTUS 9 6/ 0912 WE{NUS i bL)uc1996 159 TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .1263 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:77 ATGAA I -1
AGTCTTGCTG
ACTATTAT
AAAACCGCTA
AAAAATCCTA
CTAGCCATAC
ITAAGTCCTA
GT1'AATCTGT
CCTAAAATAA
CTTATl'ATrc
GTATTGCCT
CTCATTTCCC
ATAATCTATA
GGCAATGCGG
GAAGGAGAT1' GITTI'AGG'rr
ATCTTTGGCA
ACAATAGGCG
GCCTATCAGA
CTrGGAGCAA
GTGAAACACT
AAA
TI'GACACCCT
AACATGTGGG
TI'ATGATATG
TGGGTGTGGT
ATGA TITTAA
TTATCGCTCA
GTGAAA'TT
GGGATAATGC
TTATGTTT'
TGFI'ATTAGT
TAGG TrAAT F1'ACTCTTTA
AAGTCAATAC
ATAAAATGGC
GGAACTCTTA
CTGTGATTTG
CAAGTGGAGG
GAGCTGTATI'
GTGCTGGGGG
TCAGTGGAGG
TI'GTAGCAAG
TATGGGTATG3 TAGCqI=r'
GGCGTATAAG
TGTATTTATA
CACTTAITI'
AAGCCTAAAT
TAGCATAGGA
TTTGATGGT
TTTAGTGATT
TACAGCAGAA
CCCCCAAACC
TAAACCTI'GT
TI'TAATCCCC
AAATGAGGGA
TATAGCCCAT
TCTI'ICTA
CGTGGGGGCA
T'GGGGGTAGT
CGGACTAGCA
GGCAAGTGCT
TG?1'AAAAGT
TI'TGTTGAGC
CATGCACAAC
CGTGTGAAAG
GCGTTTGTAG
ATCAATACGA
GATGGCTTAG
AATITAGCCT
ATI'AACATGT
TI'AGGGGAAT
ATTTATGT
AAAGGCATGT
ATGATGTTAG
ACTAAACACG
AAAATTATI'G
AGI'rCTATI'G
GTCAAACGAG
GTAACAGAAA
GCAGTTATGG,
GGACTTCAAG
ATGGCAAACC
GGCTI'TGGAT
CATCTCAAAA
TCATI'rTAAA
AGGGCGATAT
GATITATCAA
TATTCTACCC
AAATCCCCAC
CAAGTGCGTA
TTAATrrGGCT TATrG TTTT
GGTCAGCAT
TATTTAGCTA
TAGC T'rTr
AAGTCACACA
ATGTCTTTGG
TAGGC7'I1TT-1
TGCCTGATT
TGATGCAAAA
TI'GCTAATCA
CTGGAGCTAA
ACAGGAGTGT
TTGATAATGA
AGTAGCCAAA
CACAAITATr GTGAG'rrr TTGGGGGATrr
ATCTGAAAAA
TAACACTAAT
TGCAATIGATA
CACAATGATA
AGGCTTATTG
AGGTTI'AATT
TCTTAAAAAG
TAATI'ATGGA
AGGCTTTTAT
CAATGTCTI'A
AACCA'FrATI'
TATCAATAAT
AATIGGCATG
AGTTAAGCAA
AGCT'ITGGG
TAAAGCTGGG
TAAAAATAPAT
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1140 1200 1260 1263 INFORMATION FOR SEQ ID NO:78: SEQUENCE CHARACTERISTICS: LENGTH: 267 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (geriomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .267 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:78 POI/US 9 6IO 91 a2 IPENUS 18 ULU 1996
ATGGATGAAC
AGCTTGCGCA
GATAGTT GCG
AATTCTATAT
GAC'FrATTAG
CAGAAACCAG
ACACCCAACA
AATGGGTATI'
TAAAATCTGT
CGTTACTAAA
TTTlAGAGCAA AACGCTCTI'A ACTTACAAGT ATCATCGCCA GCTCCTrAAG AI4TGGCAACA AGCTAAAACT TTrAACTTTA
GGATAT
TAAGACTATC
CTCATGATCC
TTGCTCAATA
AAGAAAAACC
AAATCTCATA
TATTGTC'rrA
CAAAZZ-TI'TA
AACCACAAAA
INFORMATION FOR SEQ ID NO:79: SEQUENCE CHARACTERISTICS: LENGTH: 711 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .711 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:79
GTGAAAACCT
TTI'GTATTT
TGGTCTGAA.A
GGCATAGTGA
AT=IIATJTAA
GTGGGTITTI'G
ATAGCTCCTG
TI'GCCTGGCG
ATCGGTTTT
GGGXITTTACA
GGGCI'GGAG
CCCGTTITTC
TAGGATTGTC
TTACAAGTAT
TCAACACT'A
TGGCCCACTI'
TGGTAATCCC
GCGTGGATAG
T'rTTRGT
CTIGGTTTT
TAACCGCT'C
TGGTTIITGA
GAATTTGG
AGCAAATGAA
TTCGCTTGGT
CA'FrGCCAAA
TGGGATCTT'
TGGGGATAAA
A.ACCTTI'GCG
CATGGGGCT
RC'ITGTTAGG
TGTCCATGAA
CGTAGTITCT
CAAGCCTGT
TATCA'ITTCT
GCAGGGACGA
GGGACTTTAG
CACM1I'TCC
GCTGCAGGTI'
rITCGGTCGTA
CTAGCTTI'GA
ACCCCTAAAA
ATTTGTCAAG
CATGCCCCAC
GGGATITTGC
GI'GAAGAT
GTGTATFI'GA
TGCCTTAGTC
AATTTT~ACGA
CAAACACGCT
ATCTGGCGCG
AAAACATGT'
TGCCAACTT
ACGCTCAT1'A
GCGTCGCTGT
AAGGACAAAA
IIGGGAGTT
GGGCTTGGCG
GGCGC7I'I1 1
A.AA'ITCCCGC
'rTTTATCATC
TAGCCCTATC
CCCGCTTGGT
CATGCTCTCT
TAATGATTTG
TCT1'GGTI'AC
GGGTGGTGAA,
AAACACTTAT
GGTTI'ATATC
GGTTCCI'
AGAAGAAACT
T
120 180 240 300 360 420 480 540 600 660 711 INFORMATION FOR SEQ ID SEQUENCE CHARACTERISTICS: LENGTH: 1413 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .1413 PCT/IS 96/0912.2 IPEMS 18 DEDOC99 6 (xi) SEQUENCE DESCRIPTION: SEQ ID
ATGCGCAAAT
GATAT'II'G
AI'GAGACTA
TCCAGAAAAT
AAAGAGTITTC
AAC'rrGGAGA
GTATCAGATA
GATGGTTATA
TTIGTTTAAGC
GATAATTCTT
AAAAGCGTGT
AGTGTTGCGC
AAACATGAAA
GTI'GCTTATT
TITG PIGCGC
TATAAAACTA
GTAGAGGGCG
AAGCAAATCA
CGCCATITAG
GAAGGAAATA
CAAAAAGCTI'
TATGAI'GCG
GATTTTATGG
GTTCCAATCT
T GGATGG
ATACCCTCCT
AATACAATAT
TAAGTAAAAG
ATTCATATAA
TGT1TAGAACT TGTATTrACC CAAMTrCTA
ATGTITI'AAA
GGGCAGATGA
TGAAACAATT
AAAGTTTTIAT
AATI'TGA ITA
GCCAGTI'TAT
GAGATGGTTA
CTTATGTCTA
AGAGITGGA
CCACCAACCA
CGTI'AAAATG
TCGCTAI'GT
TAAATAAAGA
TGAGFI'rCTr
AGTTI'GCT
TATCAAAAAG
GGCAAAAACT
TCTAAGACCT
TAA.AGGTTTT
ACAAGACATT
GGGAGTAGAA
CTATCGTTTC
'ITTAGAGGTT
TC'FrAGTAAC
ACAAGAAAAT
CGCTATGCCT
AGAAGAAGTT
'I'ITAGGATCT
TTIGGTITCTT
CTATAAGGAG
TI'TATTGCAA
TGCTCCCAGA
AATTTI'GCGT
ACAGGCGTAT
TTTAGATAAT
AGATACGATT
AGTITITTGGG
ACCTTI'CA
AACAAGCCCT
ACGTTTCATC
GAGG ITTTAA
TTCATTAXAC
CATCAAGCAA
ACTCTAGATG
ATCGCTACTG
GCTAAAGAGA
CTTGAAGATA
CATATAATGC
ATTACTAATA
AAAAGTI'AG
TTTCCTAAAT
TTATGCGT
TI'AGGAGCGA
ATTCACAAAA
AAATTTTTA
ATTTTAAAAA
AI'ITrAGAAG
GTATATCTCT
TACAGAAAAT
ACTI'TAGGCT
TGCTATGTGG
CACCCTAAAC
GAATACCCTA
TTG
AATACGAT
CCACAGATT
GGATCCTGGC
AAKTTATCA
AAAAAGAGGT
ACAATAAGAG
T
T
TTAATTTC
TCACTAAACA
CGCAGATATI'
GCATAGCAAC
ACAAAACATI'
ITTTATAAAAA
TGCAGGCAGG
GAAATATTIGA
ATXITTTATA
AAGCGGTA'Fr
GCGAAGAAGA
ATAGCAATTI'
ACTTGTTTTC
Arl'CTTCGCA
ATCTCCTAAG
CCGTITATIT
TTTTA.AATGT
GATTTC'TT
AT7 TTTGTAT
AGAAATGCAA
TCAAATCCCA
GCTTGTTCCA
AGTGATTATT
TAAGGGTT
TI'CAAAGGAT
GCATATCGGT
GCTATI'TAGA
TAATCCAACC
TTATATTCAA
AATTGCAGCC
TACTTTAGTG
TCCAAM'I'CA
TI'TAGAAGTC
AGTTAAAAAG
TGAACATI'GC
ATCAAAITrA
AGGGTTAATC
AA TITTAAAT
TCATAATI'GG
AGA.AAATGGC
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1140 1200 1260 1320 1380 1413 INFORMATION FOR SEQ ID NO:81: J-_EQUENCE CHARACTERISTICS: LENGTH: 369 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic).
(iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .369 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:81
GTGTI'GAAAT
GGGA
t
TII'GA
GGCAGTAAGG
ATITTAATTC
AAAGACACGC
GGCGGGGTTG
GGCGA'TrC
TCTTTGAAGA
TITTCCAAGA.
ATCTCATGT
TITTATTATT-
GCTI'GCCTGA
AGCCArrTTT
TTCCAAACAG
TATTIGCAGCC
CAATI'GCTC
GCCTGGAAAA
AATCTTATA
T'TGGGTI'C
CTI'AGCACGC
ATTCCCATGC
ATCTAAAA
AAAGGGGCTA
GGCACGGATI
TATGTCTITTG
CTATGGGAAA
'rrrrAAT
CCCTI'ATTTC
ATCTCATCI'
TITAGTGAITG
GGGGCGTI'CA
GAGCGCGGTG
GACGATTCTA
AGCGGGGATI'
AGAGCAAGCG
TTTGCAGCGC
TTGTGGGCAT
INFORMATION FOR SEQ ID NO:82: SEQUENCE CHARACTERISTICS: LENGTH: 777 base pairs ?GT/U)S 96 0912a2.
IPENUS 18 D EC1996 162 TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .777 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:82
ATGAITTTTAG
AGCTATGGCG
AAAF1'AGGCT
AACAAAAAAG
TTCTTCCCCA
ATCGCTCTI'
CAGCTCCCTI
ATCGCGCTI'A
ITI=rGGTGG
ACCGAACTTT
GTC 17I MCGC
TGGCTTTATG
TTAGGTITAG
CCCTITTTGAT
TGCTTTI'AGG
TATGGGATTr
AATATCGTT
GCGTCTTAGG
TI'CTGGCGAG
TAGCCI'ATT
AAAACAACCA
GGGTT'ITGCT
TAT'ITGAAAG
TCTATCTTTT
CGAAATTAGA
CGGCT.C TT
TTCTAAAGAA
GGGCGTGGCT
A?1'ATTTAAA
GAATAGGGCT
CAATI'CTAGC
CGGGAGCGTG
CGCTATCGCT
GCAGGA'TrA
TCITI'GCAGC
GGGGCAAIT'
AGGC ITGCTC
GCAAAAAAAA
GAGTI'AATG
AAAACGCAT
CAAATCTTAT
GGGTIGTTGG
AAAAAGGATC
GCTCAGATCG
TCTTAT1TTGT
ATCTCCACAG
ATCTTACAAC
ATTGGGGGGA
AGCCCTAAAG
CCTFFI'GGGC
GCGGCTAAAA
CCTI'TGTTAG
TAGAAGCGTI'
TACACTITTA
GTTTTAAGAC
TAAAAGCGT
CTTC7"ITFIT 1
ATTACGCCAA
CTCTTCCC
GC'ITGCAAAA
TAATGFI'AAG
ACACCCTAAT
TAACCAAACT
TCTCTT TAAT
GGGTITI'GGG
GTATI'ATI'TG
TCCTI'TAGTA
TAAAAATACA
TI'TCAAGCAA
AGACACCACA
TAGAGTCTIC
TAGCATrGCG
GGCGTGGTTT
CAAAGAAATC
CAC'ITCGCAA
CTT1'TCTTTA TTCGCTITr
TTGCGT
INFORMATION FOR SEQ ID NO:83: SEQUENCE CHARACTERISTICS: LENGTH: 231 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION I1.. .231 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:83 GTGCTAAAAT ACCCTACRRT G'FTCATGTGT GCGGATGCGG ATGATTCAAG TGTTTAATI' TAGGGTTTCT CAAGTCAAAG CCTGAAGCGC CCATTTTTTT AATGAGCTCC AAAGACCCTA AAT'TTCCTTI' TAGAAAAAAA GCGTGAAAAT TACCAATCCA
TCATTATCAG
AAGACATGCA
AAAGCTrGGA
CGCATI'CGTT
TAAGGCGGAC
AAAATTAAAG
AGArTTAAA
T
INFORMATION FOR SEQ ID NO:84: AMENDED PUTUS 961/0.9 12 iENU S L8 L) I: 163 SEQUENCE CHARACTERISTICS: LENGTH: 540 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .540 (xi) SEQUENCE DESCRIPTION: SEQ ID, NO:84 ATGCTGCTr
TTGATAGAGA
CTTAT'I'A
GAAAGCATTG
TGGATAAT
AATAGCAGTA
GTTT1'ATAG
AAGGCTAAAG
AAAGAAAACC
GCGCGGGAAG
GCGCGATCAA
TAGGGAGCGC
AAGGCTATCA
TCATTCACAT
ACTACATCCA
AAAACATGGA
GGA'ITIT'rG
ACGCCAAAGT
GAATGAGACT
ITTTAACGAGA
GGGGAGTI'AT
AATI'GAAGAG
AGAAACTAAA
CACCAGCGAA
GTII'AGC
CGTGAGCAAT
CAAACAGAI'
TTAAAAAAAG
ATGTGCC ETA
AGCCCAGAAA
AGTTTTAGCC
GAGCAGGCTC
ATGFI'TGCTA
GTC ETAAGCG
CATGTAGGGC
CTAGAAAACA
CGGTGCCTAT
AAAACCCTGA
CGGAGATIT
ATI'TAAACAG
TITI'AAAG
AAAAAATGGT
TGGCTAAAAT
TTAACGCGCA
TCATTGATAG
TGGTGTGGGC
TACAGAAAGC
GAGCGTGTIT
CTACACGCCT
GGTGCGTGTG
TCAAAAGGGC
TITTTCTTTA
TAAGGAATT
7ITGATAGTT 120 180 240 300 360 420 480 540 INFORMATION FOR SEQ ID SEQUENCE CHARACTERISTICS: LENGTH: 639 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc-feature LOCATION .639 (xi) SEQUENCE DESCRIPTION: SEQ ID
GTGTATGAAG
ITI'GAAATCT
A ITCGCGCCA
GCCAATGTGC
AGCGCTTCAG
GGGATTAAAA
GTGAATGAAA
GCCTTAGAGC
s.AATATCTTAG
AAAGGATCAC
TTGACACTAA
TGAGGGGGA
ATATTGCAAT
TGATGCTCAA
ATTTAATCGC
ATGGCGAATC
AATTGCGCTA
CCCCTATIGT
RCCAAAAGAA
TCTGGCTTCT
AGACTGGG
ATTGTCGCGC
CCCTAAAGAC
GCTTAAGCCT
TGCAGCTGTG
AATAGGCGAG
CAAACAAAAT
GGGGRGTAAA
AAGCACCAAA
CAAGGGATCC
GCGACTGAT
ACGAI'GAAA
AGCGTGTTTG
GACATGAAGC
CCTAAACTCA
GGCGATATAC
TTTGAAAACA
AACAARGTRG
GAGACTTI'TG
CTAAAACGAG
TIGATCAAAA
G TTAAACCC
TGGCTAAAGA
TTTCACCCAC
CGATAGAAAA
TAGAAAACTC
TTTI'AGAAAA
TCRCAARRGT
ATCCCAATAA
TAAAGTGGGC
CATCAAACTC
CATI'C TAAA
AGTCCCTCCT
TCAPIATIWITA
CGTGAAAATC
CAAAGAATT-A
TAAGATCGTC
CAATRCGGAG
TGTCGGTAAG
PCT/US 9 6/O091 a fPENS 18 D EC 1996 639 164 GAGCGAGCAA AATTI'AGAAG AAAAAAAAGA
AGGCGCTCC
INFORMATION FOR SEQ ID NO:86: SEQUENCE
CHARACTERISTICS:
LENGTH: 444 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1 .444 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:86
GTGATAARGA
GTATCGTTI'G
GACAAAAAGA
ACTAAAAACG
TTAGAAAAAA
CTCGCTAAAA
CTATCTI'TTG
GGGTIGATGA
AAGGCTATAT
TGGCGTATAG
GCGGTAAAAA
ATAAAAAGCT
GCCCTAACCT
ACAATATCGC
GGCCTTATTT
TGCACATCCG
AAGAGGAGAT
TAGTGCGTIC
ATTI'TACAAA
TTATGATTTC
TAAAAGCCAT
TGAAGGGGTG
TGAAAGGACT
171717
CTTATGCGTA
GCAGCGGATI'
CTCCATAAAA
ACTAAAAATA
AAAAAAAGCG
AGCATGCCGA
AA.AAGCAAAA
TAGTTAGAAA
TAGAAACCGG
ACCATGGCTC
GCGGATTAGA
ATAAAAAGTT
TTGTGAATTT
AAACCCAATA
TTATTTCTI'
AACCAAAAAC
AGAAACCGAG
AGGCGTGGAT
TTATAAACAA
CAATAAAGCC
CATGGACGGC
120 180 240 300 360 420 444 INFORMATION FOR SEQ ID NO:87: Wi SEQUENCE
CHARACTERISTICS:
LENGTH: 843 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .843 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:87
GTGATGATCG
ACGCCCATTA
ATGGAGCGCC
GAACAAGCCC
TTAGCGGATT
CAAATGGGGC
ATCCCAAAAT
TCACTGACCC
GATACTCTI'
XAAGTAACGR
TGATGATGAC
GAGCGAGCGG
GGTGGAATT'
TAAAAAAGCT
AATGAGCGAA
CGTTGAAGCG
AGGGGGCAAA
CI'GCACCTC
AGCATATG
ATCGGGGCTT
TACAAGGTTA
TTCCCCTATT
GAAGCGGAGT
ATTGTGGCGA
CGGACATCCC
TGCAAAGCGT
AAACCATTGA
TGATTGTGGT
TI'CCTATCGC
CCCAACGCCC
TCATTTACTC
GGCTAAAGAA
'rrCTATAAT
GATI'GATGAA
TrAGAATCGCT
CGAGCGTGGAT
120 180 240 300 360 I AMfFf) Q!, POC/LUS 9 6/0912 RPNUS 18 L jij
GTCGTAACCG
AAGATTGAT
GATATGCTCT
ACTGAAGATG
GATAAAGAT
GATGACATTC
TFI'ACAAC
GAAGCTCAAG
~Tr
GCTTATTAA
CTAAAGTGAT
TI'ACCCCCCC
AAATCAAAAA
TCITGCTAGA
TAGAAAGGGC
GCCAA'ITAAA
GCTTCTATC
AACCAACTTG
TTTAGACACC
AGGAACAAAC
AATCGTGGAT
AGAATCGCGC
TAAAGCGGTG
AATCGGCTAC
CCCAAGAAAC
CCTTCAAGGG
GATGGGGCGC
GGGTTAGTGC
T'ITATTAAAG
ATGCCTTTAG
AITI'TAGAAA
AACCAAGCCG
GCCAA)AGGCA
TGAG'rrTrAG
AAAGCTI'ACT
GC'ITGCATGC
CCCAAAAAGA
ACACCCCTAA
AAAAGATCAC
CCACCATTAC
ACAGAGAGAT
GGTAGGCACT
AGGAAGGGGC
CCCCTTrCCc
GGTGGAATAC
CTATCAAGGC
'ITCTACGAGC
TGACGAATTA
TTTGCAAAAT
420 480 540 600 660 720 780 840 INFORMATION FOR SEQ ID NO:88: i)SEQUENCE CHARACTERISTICS: LENGTH: 432 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 432 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:88
ATGAATTT
'ITATTGATCC
AAAGACATCG
AGGCAATI'AG
TCTATGCTGG
CCCTCTCATT
GAACGCCAAT
CGCCTTAAAC
TTAAAATCCT
TTATAGGCGC
TAACGCAGCA
CCTTCATGGT
AAGCCAAAAA
TTGAAGCCAA
TACTTTIGA
GA
TI'TAATGGAG
TCCTT'AATC
AAAAATCGCC
GCAAAGCTCC
GCTTTTAA.AA.
TATTTATAAA
ITTATGGTGC
ITAAGAGCCA
TATGGCTTGT
CTTGTAGATG,
AACGAGTTAG
GAAGAAAAAA
CAAAGTGCCT
GTTAGCGAAT
'ITGTTTCTCA
TATACCCITT
AAGACAATI'C
AAATCGCTrT
TI'TATGGGAT
GTAACGATAG
GCGGTGGTGG
TAAGGGCGTT
GCCTTATTT G
CTTCCTTTCT
CTTTAGCCCC
CTTACACATT
XITTATGC
GGAGCATCAA
INFORMATION FOR SEQ ID NO:89: ()SEQUENCE CHARACTERISTICS: LENGTH: 219 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (i)MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc feature LOCATION .219 AMFNPnFn RHFPT r F-Cr/tA)S 9 6/0912 IPENUS 16L.L bt 6 166 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:89 GTGGGGGGCT TAGCCATGCT G-GGCrT1r1 TATAATA'ITIG GCGACGGCTT TCTCGCAATG CGCGCCTAWT TATACGGTGC AAAGAAAAGC TCAAAAGAAG CGCGTTAATT TCCGCATGCA TrGATTTCAG ATCCTAGCGT GGAAAATGTA GGACCTAGT INFORMATION FOR SEQ ID SEQUENCE CHARACTERISTICS: LENGTH: 933 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION I1.. .933 (xi) SEQUENCE DESCRIPTION: SEQ ID
AAAAAATTTC
TCC'FTTCCCC
TCGGGCTAGT
GCTCGCCACA
TTTGCTITr7G
GGGGGTGGTG
120 180 219
GTGTGCTGGA
ATTGTTATGA
AAGCCTGAAA
GCTTGGGGGT
TCCATTAGAG
ATrTGGGGCAT TrAGAAGACC
ACAGGCATTI'
-CTGTAAGCT
CCCCAAAAAT
TITTI'CATTT
GGCITTGGCG
CGCATTGGCG
TTGGCAAAA
GCTAT'GTIG
ACCATGCTI'A
CGGATITGAT
TAATCCATCT
ACCTWTCTIT
TAGGCTATTI'
ATGTGCCTAA.
GCGTI'ATGGG
CTGAAAAGAT
TA'N'GAGCGC
CTI'CTACCAT
TAGTGATGAC
CAACGGATAA
CGAGTI'rTGG
CGATI'GCTGG
GCTrTrGGA
CGTTAGT
AAGAAAT'GA
TCAAGGGCTT
TGGAGGGATT
CTSGCAAGGC
TGGGCAACCC
AGCGACCACT
GCTrTI'AGGC
TTTCATTGTA
GATITTAGCG
TGCTGAAGAT
GATITCTAGG
AAACGCTAGC
CTCTGTGATI'
CATGCTCTCT
TATTTATGAA
GTTI'TCTAGC
GAGCTI'AAAG
TTGATGATGA
GGAGAGGGGA
TCTAGCGTAG
CATATITAG
ATI'GGGATIT
GTTGCTTATG
ATGAGTCA.AT
GCGGTGATGA
TI'CTATGCGA
CT1'TCGGTT
ATCCTCAGCA
TrGITITCAC
GGGGCTAGCA
ATCGTrCCGG
GTGCGATCAG
CAT
GCGCI'TAAT
TrAAAATCAT
TCGCTATTAT
TGCGCTTCAT
CTTGGATGGT
TACATAAATY
TGCTCTTTAA
GCACGGCCAG
CGATIWITCAA
TAGGGGTGGC
TCGTGAGTI'A
TITITI'GGTC
CGGTGATII'
GCTTTATTGT
GCACTAAAGA
CGTGGTGCCG
TAGAGAGATO
TCAAGCCTT
GTCTATCCGC
TATT'TCTrA
TGACTTGAGT
CCCTI'GGATC
'rrCGCA.ACTG
TAAAAACGCC
TTGCATCGCT
CGCATGGGCT
AAGAATGACG
ATACGATAAA
AGCGAGCGTA
GGCCTITGA.A
120 180 240 300 360 420 480 540 600 660 720 780 840 900 933 INFORMATION FOR SEQ ID NO:91: SEQUENCE CHARACTERISTICS: LENGTH: 345 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori PCTUS 9 6/O091 z.
fPfNS 18DEC i99, (ix) FEATURE: NAME/KEY: misc-feature LOCATION .345 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:91 GTGGGGCTTr
TTCACGCATA
CCTAAACCAA
AATCTTI'TGA
GCGAATCTT
GAAGAGCTr
TTATCGTITI'
ATCAAGCCCT
ATGACGCTT
GCGCI'TATrI' 'FrGACAGCAA
CTCATCATI'C
GTrTTTAATT
TGTCACTCAA
AAGCGCGCAT
TAGCGGCACT
GACTAATCGC
GCATGAATAC
ATAATGAAC
ACCCCCCCCT
GCGAGCTCTI'
AAAGAAGGGG
TGGAGCGAAG
ATCAAAAAAA
ACCAAACCTC
AITI'CACGCA
TAATCAGCTT
CAAGGGATGT
CCTrCATTCT
TI'AGG
CCCCTATGCT
ACTCACTATC
GCCTAACGAC
GAAAATCAGC
T'FTAACCAAA
120 180 240 300 345 INFORMATION FOR SEQ ID NO:92: SEQUENCE CHARACTERISTICS: LENGTH: 600 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .600 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:92
ATGCTTGTAG
TATTCTAGAA
ATT~GGGGCTT
GTGATI'GACG
TTAGTGGATA
'ITTATAGATG
GAAGACATGA
ACGAAA'FTAG
AAGCCTATCA
AATGAGTATT
GGCCAACAGG
TGCTGGCTAA
TGGAGCAAI'
CTAAGGATIT
CGACAGGGCA
GGGGTTATAA
AAGATATI'TA
ATGAGAGTAG
GTTATCTFI'C
TAGTGGAFI'G
CGTGGGGAAA
AAAATACAAG
GAGI'GGTAT
TGCTAAAGAA
T1'CGCAATAC
TATI'GATGTA
TGATrC7=~
GGGGTTAGGG
TGTCGGCCAA
CATGCTAGAT
ACGACGACTT
GTGGGCATTA
GCTAATAAAA
ATTGAAGCTI'
GATAAGGAAA
TCCTI'AGTGC
GGGGTGT1'AG
AATTTGTT
GAAGTGCCTA
GGCTF1'AGTA
TGGCTAAAT
TCACTTI'AGA
TGAAAATGAG
TGGAATACTG
AAATTGCCGG
TTI'CGGTTAC
GGATTG3ACAC
CTTTAGTGCA
TGGATITGAA
ACCCTAATAA
AGCCGCACGC
CAATTATCGC
TATAGAAGCG
CGATITTAP1
ITI'GAAAGAG
CACTAAGTAT
TTTIAATCTTT
TGAAAGCCAA
AGTGGCTACT
GGAACAAGCA
120 180 240 300 360 420 480 540 600 INFORMATION FOR SEQ ID NO:93: SEQUENCE CHARACTERISTICS: LENGTH: 792 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA -(genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: POUS 9 6/O091 2-L fPENUS 18 8t- 61996 ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1 .792 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:93
GTGGGAGGAG
TATGACCGAT
TTTAACGGGA
GCTTTI'TGA
AGTCATATCA
ACCTGGACAA
GTGGTGCTAA
GGTAAAATGC
TCGGTTI'AA
TATTTTIGTAA
GTGCG TTG
GCGAGCGTGA
GTGGGGCTTA
CGAGTGGCGT
CGAGCTTI'AT
TGGTTAAAAG
ACATCATGCA
AAAGAAACGA
ATICTTICTAA
CGAGCGTGAA
AACCTCAAGT
AAAATCCAGC
CGCTCAACAT
CGGCGAGGTI
TGGGTGAAAA
TCACAGGAGG
AAATGGGCTr
T
TTCTGGGGGC
CGTGATCCI'
TTcTTTGGCT
ATI'CAC'ITTG
TTCC'I'IGCTC
TGGGAATTAC
GGGCTTGAGC
TTACCAACAA
GGGGTIAGAG
GGGTAGGGAT
CACTTTATITG
CGAAATGCAT
GCAATACCAA
AATGGCACGC
GGGGGTTATG
AATA.ATGTGG
AGCGCGAAT G
TCTGTGTI'GA
GGCTATGAT
TATCATTTCA
TCGTCATGC
AGCCGTAAAT
CITTI'GATCA
TACCGCAAGG
TTGTGGCGTT
GATC'ITAATA
TATGGCTT
TGGCTTAT GG
ATGTGGGGAT
AAACT1'ATGG
ACCAACGCTA
TCATGTTCAA
TAGGCTTGAG
ATICAAACCC
ATTTTGGTAA
AAGCTAAAGG
GGGAAATTr
TGATGTATGT
TCACTGGGAA
GAATGTGGGC
CTATAGCGGT
GTATGCGAGG
AGGCAATGCG
CAACTACAAC
ACAAAAAAGC
CGGGATGAAA
TTCTAACGAA
AAATI'CCTAT
CGACAATGTG
TAACACTIVIT
GAATGCGGGG
TGTGGGCATG
INFORMATION FOR SEQ ID NO:94: Ci) SEQUENCE CHARACTERISTICS: LENGTH: 1017 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .1017 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:94
ATGGACGGCT
ATCITTTGCCG
RTGACTGGAG
GAGAGTCATA
CAAAAGGGCG
TATGGCCATA
TTAAAAATCG
GAGTGCCAGG
ACGCATITTC
CAAGGCTATG
AAAGACGCT
GGAAAGCCGG
CCTTTAAGTT
TTAAATAAAG
AATAACAAAC
AAC AAC CGCCT
"%ATGATGAAG
ATGGGTTTAA
GGGATGATGT
CGATGGTGCC
AAGATI'TCGC
AGAACGCTTC
TCGCGCTCAT
CTCTCTI'TAG
TTTATGATGT
TAGGGGITTF
ATGTCATCCT
TGAAAGAAAG
TAAC TITAGC
GCTTACTGGT
AITTTAAATr
GGACGCAT
ATGAATCAGG
GAGTGGGAT'
AATGCAAGAC
GAGCGCTTTA
AAAGGGAATA
CCTAGCTCCT
TrI'AAACAGC
TGCCTCTCAA
TAGCGGCGAT
TAAI'CAGTG
AAAAGATGAT
TTCAAGTGCG
AAACGCCCTT
CCAACTCAAT
TTTACGAGTT
AAAACCCTTI'
AATCTTAGGC
AGCGATTCAA
GGTI'CAGGGC
TrGGGCCAAA
GAAGTCAAAG
GAAACGATTG
AAAGATITI'A
GTTTWIAGTCC
GGGTI'CAAAG
GAAT1'AGTGC
AAAAATTTAC
GGGGTGAGCG
TTITATTACG
CAAAGCATTA
TTGATTCTAC
AAGGCTCAAA
AACTATI'CAA
GCCCTTGCGC
GAAATTGAAA
AAACTCAAGT
AAAATGAATG
ITCCCATAGA
AAATTCACGC
CTAAAAATAC
AA6ATCAAAGC CTT1'AGGGCA ACATGC?1'AA
AGCTTAAAAT
TAGGGGATAA
AAAAAGTCAA
TrATAGGCTT
CCTTATGGA
TCAATGC CCC
ACCACCAATT
AAGTGGAI'TC
TTTTAAGGT
TATCCAACAC
CGTI'AAAATC
ATGCATGCTA
TAATATCCGT
CCGTTI'GAAT
GTI'TAGAAAA
AAACGCCCTA
AAACTACAAC
ACTTGAAT'G
AGACTITITT
TCTCAAACCT
ACCGGGTAAT
GCGCTTATCC
TIAAAGCTT
CATTCCITAC
TATCRCTA
TGAM4.AT 120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1017 PA arkinrn i PCTIUS 96/0912a2 IPENS 18 DEC -996 INFORMATION FOR SEQ ID SEQUENCE CHARACTERISTICS: LENGTH: 438 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .438 (xi) SEQUENCE DESCRIPTION: SEQ ID
ATGCCATACG
TGTATGATAA
CAAATCAITA
CAAATCFFFI'
TATTACAAGG
AAAGAAAGCT
CGITATGCGA
CCTTAAGAAA
ATITTGCATGC
AGACAGAGCC
CTTTTGTATC
ACATCITAAA
ATGAGCCTAA
TTTTAGTGAT
AAGATTI'TC
CAAAAGCTAT
TGCTCTI'TG
CCAATACGAT
CAAACTCAAC
GATTGAATI'A
GAACACCCTT
AAACGCCTIT
CTGTWITCTC
GAGTGCTTGA
GATAACAACC
CCCGTATTCA
GCGATTTTAC
TTAGCGTAT'
TATTGTITT
CTTTGCCCCC
AAGACTTGAT
AAGATGAGAG
TCGCITCTCA
TGCCTAAAAA
TGAACACCA
TTAATTGTT
AGCGCACCAG
GCTGCAAAAT
CCTTAAAACT
AACTCCAGCT
GGTGGTGGGC
GAAACAACGA
120 180 240 300 360 420 438 TPTTCAATATC CAAGTCTI' INFORMATION FOR SEQ ID NO:96: SEQUENCE CHARACTERISTICS: LENGTH: 180 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii),HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .180 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:96 ATGCCTATI'A ACCCTCTCTA TC'ITTTCCCC AATCTTrIA GGCATGATGA GTATT7 =A CGCTI'CCAGT TACCAA'TrG GTGGCGAGTC TAT TTT AGA TGGGCTTGAT GGGCGTGTCG CCGCTAGCAG TArTI"TA TCATGGCGTG TT'GTTAGTG CAAGGCTTAC CAAACACCAC INFORMATION FOR SEQ ID NO:97: SEQUENCE CHARACTERISTICS: AkA rftr cr'urv~ 18DEC 1i996 LENGTH: 699 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .699 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:97
ATGCTFI'CAG
CTITTTCCTG
ATCATTTATG
AGCTCTTTCT
G'ITTCAGGGG
CTCGCTGGTA
GCTAAAAGCG
ATGCCTTTAA
TACCCTCTTT1
ACTTCATATA
TT1TGAAGAFI' AATT1'TAGGG ccTTGC'ITTC AACTT1'CAGA
GAGGTI'TTCT
CGCACATGGG
CGGTGTI'TAT
TCTTGGAAGA
CTCCTGIWIT
GCATTGGTT
TGGCTATCAT
AAGATGTGTT
TAAACGCTCG
ATI'TATYCYA
TAAAATGGGG
AATI'TATTTA
AGCCTACGCT
AGTCGTGGTG
GATGTITGCG
ACGCGCCAGC
TGCAGCC'TI'
TGTGGGAGAG
TGCCGGGACA
cTTTGGCAAC
TGAGGTAGGG
AAGCGCTTTT
ACTTACGCCT
ACCCCCATAG
CAAAAAGAT'
CTI'GGGGTT
CATGGCGTTA
AGT1'TAGAAA
TTTATGATCG
TTTGARCT
AGCCTCAT'C
rrAAAAACCG GFI'rTAAGCG
AAAACCGAT
TAIACGCTT
CCATTGTGGC
TAAAAACCCT
TTTCTTTCAA
TCGTCATGGG
TCGCTCGCT'
TTrAAT(3GC
TGTTAGGGTT
TATCAGCGGT
GGAACAACCA
TGATI'TAGC
CTTGCTCCCG
GCTGTGCATG
CATCGCTI'AT
TGTTGAAGGG
TGGATCGATC
GAATGTGGGC
TTTTGCCACT
TI'ACATRCTC
AATCAGCGTG
CT'TGATCT
120 180 240 300 360 420 480 540 600 660 699 INFORMATION FOR SEQ ID NO:98: SEQUENCE CHARACTERISTICS: LENGTH: 96 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii),HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .96 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:98 GTGGAATTGA TTAGCAATAA CCCTAACGCC AGCCAACAAT CTATCGTTAT
TCCTTTGGAG
AcTFI~ZCCT TGGCGCGAGC GTTAAAGGGA
ATCTT
INFORMATION FOR SEQ ID NO:99: 1 SEQUENCE CHARACTERISTICS: LENGTH: 513 base pairs MC 0 1 POUS 9 6IO0912% WEA/US 18 8DE C1996 TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .513 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:99
ATGAAAATTT
TTGTGATGC
AAAATI'CTAA
AGCGCTCTCA
ATCGCTTI'T
AACCCTTT'G
GAAGAAGAA.A
AAAGTGGGCG
CGCGCATTTG
TTGGGACTGA
GT'ITAGGCAT
TCGGTAAAGA
CTI'CCATAGG
TAACCGAAGA
AAGACAATIGG
GAGCGATTGA
AGAGCGTCGG
AAGCACTCTY
TGGCGTGAGG
TGCTGCCGGA
CACCAGAAAG
CTATAATGTG
CATGCGCTGT
CATCAAG'FIT
AGAAATCTT
TAGCGCTAAA
TYCCCAAACA
GGTAAAGCAG
'rrGTA'rITrA
AGCGGCTATA
ATCCAAATAG
GATGCGGGCA
TI'CAATrCCT
CATGATGAAG
AGGATAGACG
GGGTGAAACT
AAAAACATITC
TGGTAGAAAA
GGCCTATGCC
TTATGATAAG
ATGGTTATAA
AATTACTGCA
ATGTGATAGG
CACCCCCATG
TCAAACGAAT
CGCTTITAGTG
TACCCCTGCG
CGCGAGCCAC
ACTCAAAGAA
TTCTAGCTAT
GCCGCTATAT
INFORMATION FOR SEQ ID NO:l00: SEQUENCE CHARACTERISTICS: LENGTH: 99 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .99 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:100 GTGCGAGCCG TGTTTIGTCT TGGTrGAAA GCGGCGTT GTATAGGGAT TTFITCTAT GGCGCTTAT'I ATTTCCTAGA TGAGFT1'TA ATCAAGCTC INFORMATION FOR SEQ ID NO:l0l: SEQUENCE CHARACTERISTICS: LENGTH: 210 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular 4rklncn f"HFFT POUS 9 6/ 0912.
[PENUS 18DE 1996 1.72 (ii) MOLECULE TYPE: DNA (genornic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .210 (xi) SEQUENCE DESCRIPTION: SEQ ID GTGAGGAGCG GTAAAAGATT AGGCTATACC AATCAAGTGA GGTAT'TGGGG GGTCAGATFI' AGGCGCTTTA ATGGTI'TGCA CACCCAAGAT TARRAATGCA ?IGTGTCT AATGTGGAAT TI'GGAAAAA ATCAACCCGG CCAGCGCGCT TCACCGATAT TGTCAATATC CCGCCCTAAA ACGCTACGGC GGCACGCAGA TTTAGACGT INFORMATION FOR SEQ ID NO:102: SEQUENCE CHARACTERISTICS: LENGTH: 390 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc-feature LOCATION .390 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:102
ATGAATCI'TG
TI'GTGGGCA
TTTAGCGTGA
AAAGT7 TTTG
ACCTTTTCTT
GCCATI'TCTI'
T7IITGCTA
TCT'ITTTGTG
AAATGATGCC
ATCTCATAGG
GTGATGATITT
CTrATGGGTT
ATGTCTTAGG
AGAA ITITGT
GGCCGCTCTA
CAGTAAA'T1' GTGT1'ITATC
TGGGATTI'TC
AGACACTTTA
CACTAACCTT
AGGCGTTAAT
GGAGGGGCTA
TTAATG'TrG
ATCGGCTTTA
ITTGTAACCG
AAACTCI'GC
TI'AGGGCTTA
TAGGGAGCTC
AAAGTTTCCC
TGGGGCATIT
GAGTITrAGG,
AAAAATCCCA
T
I'GGGGTAGC
GTI'AAGGTAT
TTTAGGGACT
GGCCGCTAAA
GGGTTTTACG
ATACCTGAA~
TATCGGTI'GG
INFORMATION FOR SEQ ID NO:103: SEQUENCE CHARACTERISTICS: LENGTH: 237 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO Nl dl' kossow sk POUS 96/0912a jPENUS 18 D EC 1996 (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc-feature LOCATION .237 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:103 ATGTI'GGAAA AACTGATTGA, AAGAGTGTI'G TTrGCCACTC TGCATTGCCA T1TCGITAGT GTTGGTGGTI' TTAGGCTATG CACATGCTCA GCCATI'IARA CACCATI'AGT GAAACGGA T TTAGTGGAIT TGTTGGTICA TGCCGGGCT TG'ITTTGATG GT1'GG'FTGCT
TGTTCATGAA
TGGTTTTATC
GTGCTGCTCG
AGCCCCTI'TA
AGAGTI'GTGG
AGCCITAGGT
CCAGT1'A INFORMATION FOR SEQ ID NO:l04: SEQUENCE CHARACTERISTICS: LENGTH: 306 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc-feature LOCATION .306 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:104
ATGCACTATC
TTAAGGATCA
GCTCGTTI'TG
CACCAAAGCT
ATCCAATTTT
ACACTI'
AAITAACAAG
AAATGCGCGT
GCTATGTGGT
TCCAACTGGG
TAAGCCCGT
T1'CAATATA
GITTTGTITGC
TTAATCCCC
TATI'GCGGTG
AATGTCAT1'A
ATACAAGATC
ITTrAGGGG
CTACTCATTI'
CTAATGGGCT
SAA.AGCATCG
'TTITTATAAC
ITFFI'GTATC
TATCAGGGAG
ATGTIITIGG
CTAAAATCAG
T1'GTCATGTG
TAACGGCTTG
TTI'AACCCCA
GAGCTTITA
T TTTAAATTA INFORMATION FOR SEQ ID NO:105: SEQUENCE CHARACTERISTICS: LENGTH: 45 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No vi) ORIGINAL SOURCE: _1\1,v ORGANISM: Helicobacter pylori POUS 9 6/ 0912.a iPLNUS 1 8 D Ec 1996 174 (ix) FEATURE: NAME/KEY: misc_feature LOCATION (xi) SEQUENCE DESCRIPTION: SEQ ID NO:105 GTGGATATGA AI4GACGCTGT AGGGACTTAT AAACTAYTCA GGGCT INFORMATION FOR SEQ ID NO:106: SEQUENCE CHARACTERISTICS: LENGTH: 3081 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc feature LOCATION .3081 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:106 GTGTG TTAG 3AACAAAAAC
AAGCAATGGG
AGCAAGGACA
TATGACGCTG
ATAGAAGAAT
TTAGCTI'ATA
AAGTTGGATA
GATATTAGTC
CTAGCC'TI'G
CGCGCTAGAG
TTTAACCG
TTAACCCCTG
TATGGGGAAG
AATCGCTTTT
GATATTGTCT
GGGGATAAAC
GTGGC'TrAG
GAGGGCAAGA
AAAGTGGCTI
AAAAGCTATG
GGCACACAAC
TTAGAAGCGC
GAACTTTTAG
AAAGAATI'AG
ATAGCTAAAG
GGTATCCCAC
GAT'rrGTTTA
ATGGGCGTAG
TGGAGACCTG
CACCAAAATG
TACGATAGCC
SAACGCGCACA
ACCATCAGGT
GCATGGGATT
GCGATGAATI'
CCACTGAA
TGGTTATCGC
TGAAAGAAGA
AAAATAACCC
AAATCCGTGC
AAATGGGGAT
AAACTTCTAT
ATTI'GTI'TAT
GCACGCCTAT
ATGTGTTAAA
TGGTGAATGA
CTAAATTTAG
CTAATGATGA
CTATCAATGT
AAAATGGAAA
AAAGCCAAAA
TGGAT1'ACCG
CTATGGCAA.A
TTIGGTI'CAT
TAGATAACGC
AAAGCTTGTC
AGAACGAGCT
GCTGTTCGTr
AAAATGAAAT
AAAAGCTCAA
GCACTAATGT
ATGAATTGTT
ATCCTGAAAA
GTATGTGGCA
AA'FrAGGCTT
TGGAGCAGGC
AGTGAATAAA
TI'ATAAGGCT
AGAAAGAGAA
GCACACCCAT
AGAGCTAGTG
TAGAGAAACT
TAAATACGAT
TGACAA'T1'G
GGAAAAAAT
TAAAACGCGC
AGCTAAT1'CC
AGAAAGAGGG
TITTGAA'ITA
CGATGTGCAA
TAITTTAAAG
GGTGGTGAAA
ATATAATGAA
AGGGCAAGAC
CTTGATTGAC
AAATATCTAT
AGGGCTATCC
TCACGAAACT
TAGTTATGAT
CAAAGAGAAA
TGATGITTAT
CGCTTrCATC
TCGTGGCGGA
GCAAGAAAGA
GCAAATGGA.A
CTTTAGAATG
AATCATAGAA
GAATGAATTA
AAGACTTGT
ACGCTCATTG
TACCCTAACG
CTrTTATTCA
TTGGAATTAT
AATGCTGAAA.
AAAAAACCCA
GCGATTTTAG
ATTGTGGATG
GCAGGACTN'G
TACTTGCATC
TI'GAGTGAAA
TTAGAATTCT
GACACTTCCG
GGCTI'AAGCA
CATAACCCCC
AGAAGCGAAG
GGCTCTATCA
AATATCCTT
CCTAACGCTA
GAGAATTATI'
ACACCCAAAA
GAAAATAAAA
GAAAAGGGCA
GAAGCTAAAA
AGCGATGI'T
CATGACGCTA
GTCAGGGTAT
TIAGTCGCTA
GGGCGTGGGA
AAAATCTATC
ACTAAATCTA
GAAGACTA
GCGCTATAGC
CCGTGCCTAA
CTAATGTGTT
ATCAAATCGC
TGTCTAACCC
AAACTI'TGA
ATGAAAGAGC
AAAAACAAGG
AAGCCCACT
GTAACCAACA
AAAACGATAA
TGTATCACTI'
TI'GATGATI'G
CTCAAAGTA
CCATGTATAG
ACTTTGTGCC
AAGTGGCTCA
TI'GATAGGAT
CTI'GCACCAC
AAGTAGAA
TAGAAACTCA
CCCATAGCCA
ATCCCCTAGA
ATCTI'ATCGC
GCGTCAATI'
TAAGGCATT
AAACCGAAGA
TATTGGGCAG
TGCATGAATI'
TAAGGCAAGG
GTTACGCCAC
AAGGCATAGA
ATATGGGTAG
CAGCTGCATG
CCATI'TAACC
AGTTGTTGAT
TAACAACAAT
TAGAGGAATC
AAGGCAAGAA
CTTTIAAAAAC
CTCTCATATT
ATI'CAAAAAT
AGGCTCTAAT
GAAAATCATG
GCAACGCTAT
GGCTAAGACT
TAAAATGGTT
AGCIPTTGCG
TAAAGTGTAT
ATI'CATTGGA
GCAAAAATGC
AGACGCTAGA
AGAAT1TITCT
T'GCCACTAAA
AAAAGTCAGT
TAAAGCTCAA
TCCTAGCAAG
AGATGAAGAG
AGTCCAAATG
GCAAAAGCAG
TCCTGCTAAA
AGATTGCCCA
CAATATTTTIA
TGAAAAGACT
GCAATTTAGA
CTCTAATGCG
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1140 1200 1260 1320 1380 1440 1500 1560 1620 1680 1740 1800 1860 1920 1980 I I c PGT/U 96/09122 IPENUS 1 8 DEC 1996
AGCGAGATGA
GCGGAGATTA
GAAGAAAGCT
TTAGAAACGC
TTGAAAAATG
AAAGAAAACG
CAAATAGCCG
TI'GAACACCT
GTGGTGAATG
CCCAATATTG
AGCTCITATA
GCTATCACTA
AAAAATATCG
TACCTGCAAG
AAAGACAGAA
AACGCTGAAA
ACAAAGAGTC
AAAGGAGATG
ACTAAATCAA
AAGCAGAAGC
AAAGCGAAGA
TAAAAAACAA
?I'CAAAGATC
AAGAAAGTAA
CCTCTATGAG
AACAAAATAA
TGTTGTAA.
CTTATAAAAC
CCTATAGCCC
ATICTGCGC
AACTCCCTGA
CTAAATACAC
CT
T
TIA.AA.ATG
A'FTATAAGCC
AAAGAGCGAG
ATGATGAAAT
AAATCGCTAA
TGGGTAGAAG
GACAGGCAAT
ATCAAAATAC
CGCITCTAA.A
CGTAATAATC
GGATTATIGAG
TGAAGAA ITA
AGAAAAGCTA
TGAAGAAGAA
TAAGTATCAA
TAGCAATATG
TGAGATCAAG
AAAAATCAAG
AAGATTAGTG
GGATCATAAA
TGCGTTCAAC
TTI'AGAGAAT
AGAGCCAGCT
TAATGTGAT
CCCTrGATI'A
AAAGCCTTCA
TTIGGA ITATC
CCCACTCATA
CTTATCAAAG
ACGCACAAGA
GACGCTATI'A
GATTATAAGC
GTGGAG'ITTA
G1TTTATAAAA
TI'TGATGGGT
GAATI'AGAAA
GAGCAAAAAC
ACTCTAATAG
CCTAAATCTA
GAGAGGGAAG
ACAGAACAAG
TACTACGAGA
TI'GAAGAAGT
ATAAAGAGCA
TAAAACAGGA
CAGAGATCAA
TTAAAGAGGT
AACTCAAAGA
AAAAGCAATT
T1'TAGAATA
GTI'TAAGCCC
ACGATACTAT
T1T1'AAAAAG
ACTCCATTGA
CTI'CT1ACCC
ATGATAGC
AAGAAGTCT1'
AGCAAGGGGT
TGATTGAAAA
ACGAACAAGA
CAAAI'GAGA
TT1ACTITCAAT
ATI'GAAAGAT
GCTCTATGAT
AGAGCCTTrA
ACAAAACAAG
TCAAGCAAT
CAAGGGCTT'
TAAAGACAAT
CAACATGTT
GTTGGATAAC
AATCACGAAA
ACGACTAGAA
TAAAATGAGC
AAAGAATT'rG
TAAGGGGAAC
AGAAATAGAA
AGTGGAAAI
2040 2100 2160 2220 2280 2340 2400 2460 2520 2580 2640 2700 2760 2820 2880 2940 3000 3060 3081 INFORMATION FOR SEQ ID NO:107: SEQUENCE CHARACTERISTICS: LENGTH: 186 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1 .186 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:107 ATGGCCGAAG AAGAAAAGAC CGAACTCCCT AGCGCGAAAA AAATCCAAAA AGCCAGAGAA GAAGGCAATG TGCCTAAAAG CATGGAAGTG GTGGGGGTTT TTAGGGTTAT TGGCTGGGCT AATGAGTAT1 TI'TGITTrr F1ATATGGTG GGTGGGATGG CTI'AGCGAG ATGTATCGCC
ATGTGT
INFORMATION FOR SEQ ID NO:108: SEQUENCE CHARACTERISTICS: LENGTH: 711 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: PO/U 9 6/O')i9 I.P&V US 18 D E C199 6 176 ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .711 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:108
ATGAAAACAC
GAAGATATAA
GTGCTCAAAA
GGTCAAGAAG
TAT'GAAAG
AAGACTTATA
CAAAAGACTG
GGGAAGCTGA
AAGGCATATC
GTAGAAAGCC
AACAAGGTCT
AGTAAGCGAC
TCGTGAAAAA
CAAGCGGCTI'
ACCTAGATIGA
ATGCTCTAAA
CCAATI'?TGA
TGTCTAGCCC
CTGAGCAACA
AAATCGAGCA
AGAGCAACAT
TAAAAAATAA
TTTTAAATTA
AATACCTACA
TACCATATAT
AAAGCAACTG
GATTrTCA
CATCAAAAAA
AGCGAATGAG
TGAACT1 A
ATGCGGAATA
AGAAAAACAA
TGGAGGTACA
AAATrTCATC T1'TAGAGGAG TCTlTTGC
GATAACACCT
ACCACTAGCC
GCGGCCATrG
TTATI'TCA
TTAACCTATA
TCCGATAAAG
AATATAAGAG
GCTTCCTTAA
AAAGGAATCA
?I'GGACGCAT
TATTGTCTIGT
ACCAAGAGAC
CTAGCGCTAA
CTTrIGAGAGG
TCTCAGAAGA
TGAAAATCAA
TrTTAGTTCT
AGCGTIAGA
TCACTGCTI'C
AAAAGCTTAT
TAGAAAGATC
TCATTGTTAA
TTTGATGGCA
CAACCAACAA
TAATAAAATA
AGATITTAGCG
TGTGATI"ITr
TCCCTTAGAC
TTATI'GTGAG
AACTTCTCTA
ACAGACGCTI'
GTrAGCTCAC
CCTAGAACAA
A
120 180 240 300 360 420 480 540 600 660 711 AGAA.AGGCAA TCAAGTAAGA INFORMATION FOR SEQ ID NO:109: SEQUENCE CHARACTERISTICS: LENGTH: 249 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacterpylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .249 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:109 GTGAGCGAAA AAGACAGGGC GTTTCTTTTA GCGAGCT'GT GTGTr1'GGAG AAGACACGCC CATAAAAI'G ATCAAGCCC AAGGGAGCGG ACTACCTCAA TAAAGAAGTC ATAGGGAGCG TTGATAGAAT TTGAAGAAGG TTATrCCACA AGCGCTATCA
CATAATGAT
INFORMATION FOR SEQ ID NO:ll0: SEQUENCE CHARACTERISTICS: LENGTH: 192 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO
CTTGCGTGGA
TAAAGCCTGA
AGTI'GGCTAA
TAGAAAAAAT
TTATGTTGTG
TATTTTAGTC
AGAAACCCGT
TAAAAGGACA
120 180 240 249 &wMpn %HUFT PUT/US 9 61/091?2 IPEAIUS 18 EC 1996 (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .192 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:11O GTGTATGACA AATCCTI'GTG TAAGACCATIG GCGCTAGCGT AGGGCGATGG TGG'ITAATGG AGGGGGGACA GGTGAAATCG GCGTGCGAAT TGAAAAATAA CGAAA'FITrA GAGTATGATT TPIRCCCCCCT CA INFORMATION FOR SEQ ID NO:lll: SEQUENCE CHARACTERISTICS: LENGTH: 684 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc-feature LOCATION .684 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:l1l TGAAGGC'ITT AGGCGI'AAA TGTTGCATGA CATI'ACGCAT TGAGCGCTAA AGAT7 =GRT
ATGCTAGTAG
ATCAG TITGA
AAAACCACTC
ATTTAAACC
GAT7"TITTAG
AGCGAI'ITTG
AGAGAGTTCA
TCACGAAACG
AGAGAAGAGA
TCTACGCATT
GCTAAAGTGG
GCAGCGTATA
AAATAGAGAA
AACTACCCAA
TGTTAAAAAT
AAAAGATTGG
ATCCTAAATT
ATGAATCAAA
AAGCCCTTC
C'rrCITrGTA
TITTTGAGTT
TGGTGGTGGA.
TGGC77ITGG AAGAAAGGTr
TTTGACTAAA
ACAGCAATT'
TTTAGCCGGA
TATAGAGACT
AACGCCTTTA
AGCCCTAAAT
AAAAGGCATG
TC TTTGAT
AATCGCTAAG
TGTGGAAAAG
GGATGTGGGG
GAAA
AC'ITATGGGA
ATAGGGCTITT
TrGAATrI'GA
AAAAAAAGCG
AAAGCGATCG
TI'GTTAAAAC
AGGGAAAAAT
GAGCCGGTGG
GAGTTAGCC
TATI'TAGACA
GAATTAAAAA
GT1'TAAAAGC
TAGGGCCTAA
ACTATCAAGG
TGGCGTTTT
CTTI'TATAA
GCTTCAGCGT
TGCAGCTGAT
CTGGGATTGA
AAAACGCAAG
GCGCGATTT
AAGGGTATAG
GCTAGACAAT
TGGGGCGGGT
GGAAGTGAAA
AAGCGATGGC
GGATI'I'rT
GCCTTTAAAA
TIAACCCTA
CCCTATI'GCA
CITGCTAGTC
TITTAAAAGAA
CAGTTTGGAG
INFORMATION FOR SEQ ID NO:112: SEQUENCE CHARACTERISTICS: LENGTH: 819 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO
A,
POT/US 9 6IO0912 Z 'PEN/US 180DE C1996 (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .819 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:112
ATGAACAAGC
AACGATAAGA
GAGCGTTTGT
CTACTCAACA
TTAAAAATCA
TCTTGAATA.
GAGAATGTT
GAGACGATGA
TGGGAATACG
AGTAGCGATC
AACGCGTATI'
GATGAAAACT
CTTAACTTGC
TTAAAAATG
TTTTTAGC
'rrGAGAATT
TTAAAAATCG
CTCTCAAAGA
CTTTCAAGGC
TGATGGGGTA
TTTICATACGA
AAAGGCATGG
ACTTTGCCTI'
CTGTGGAGTT
TAAAAATAAG
TAAAGATCAT
TTGATGGCGT
GGATI'AGCGT
TITTATI'GTT
AATGGGGGAG
TAAGGATI'C
AAACGGGCTT
T1'CAAGTAAT TrCGTATGTT GC'FrAAAACG TTTrTGATT
ACAAAAGATC
TAAGGAAGCG
CTCCAATAAC
TCAAATCATT
GCGI'TTATC
=7T'rTTGAT
GGGGGAATGC
CGATCCTACC
TATGAAATGG
TTATCGITFIA
CCCCTAGCGT
TTGCCTAT'A
GAATACGITTT
ATGGATATA
AAGCTCCCTA
AGCGGGAAAT
CC TTGTGGC GCTAAkAGAAA
CATATCACTG
GCGATGCCT
TITI'AAGTGC
ACATGAACAA
GGCGTITTGGA
AITTTrGACAA
TI'GCCAAAAG
GAATGCAAAG
TAGACCCTAA
GACGGGTGTC
ACGCGAGAGC
A'FrGGCTGAG
AACCCAAAAT
ACAGACAACA
ACGCAAAAAA
TGATGCTTTA
GCTI"ITII'A
TCCT'AAAA
ACCAAGCGTG
CATCAACAAT
CTCI'CAGGC
CATITI'GATA
TITAAAGGAG
CTTAGITG
CGTGAATCAA
CATI"ITIAT
AGAAATCGCT
CCCTATCAT
INFORMATION FOR SEQ ID NO:113: SEQUENCE CHARACTERISTICS: LENGTH: 45 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION (xi) SEQUENCE DESCRIPTION: SEQ ID NO:113 GTGTCTCGCC CGTTCAA7AAC GATCAAAAA CCCCCACAAC CCCCT INFORMATION FOR SEQ ID NO:114: SEQUENCE CHARACTERISTICS: LENGTH: 201 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genornic) HYPOTHETICAL: NO MiT/k 9 6/O0912 IPEA/US 18UDEC1996 179 (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .201 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:114
ATGATCGCTG
GGGCTTGTGG
TATITI'GGAG
TTAGAGGGTG
TATTACCGCC CTTGTF7TT ATGGGGAGCT C'rITAATGGT GAGCTGTCCT TGCGCG'ITAG GCGTGGGAGC GGCGAGCCGA AAGGGGA'TTT CTTACCCAAA C T1'GATIGAGTG GATTTATAGG TGAITI'CTGT GCCTTTAGGG TAATGAAAGG AGTGCATGTI' INFORMATION FOR SEQ ID SEQUENCE CHARACTERISTICS: LENGTH: 969 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .969 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:115
GTGCAACACT
ATTATCGCTC
GACGAGCT
AAAGCGGATG
GATGAAGAAA
TTGCAGAAAA
GCGTTGTTGA
ACTF1'GGAAT.
TATr1'AATGC
GCGTCGTITAG
TITI'GGCAAG
ATGAATATCC
CAAGGGTTGC
CTATIGCATA
CAAATCTTITC
ATGGTGGCT
TCAATTTCCT
TGTGA'TT
TGCAAAAATT
TAAAGCATGC
TGGAAATGAG
AAATCGCTGT
CAAAAGACAC
AGCTTITGCA
GTI7TGGAAGA
ATI'TAATAGA
ATGAAAAA
AAATTGATAC
CTGCTTAT
TFI'TGGATCA
GCCCTATAAA
CTTITIGAAAG
CTATAAAGAT
ATTAGAACAG
CGCCCAAALAT
TAAAATI'CC
CATTGAAATC
TTTAGATTTA
CGTGAAAGAA
TGCGTATGAA
AT1'AGAGGTG
GAATAAGGAA
AATCGCTCTG
AACCGAACGG
ITTAGAAAAA
CAAACCTI'GC
AGCGAGTCTG
CCATAGGTGT
TCTTTATrr
GCTAGAGCGT
CAAAACGCCT
AGI'TGATGT
TI'AAAAGGGC
TTGGCTAAAA
ATTGCGCT
'ITAGAAAAAG
CCTAAAATTG
GATGCGGCTA
AATCACTTAA
CTAGAAAATG
CATGCCC
T
'TT
CAAATrTTTI'G
ACTITTGAAT
CCTGTGTGTT
CTATCGCTTT
ATTI'CACCCG
ATGCGAGCAG
TI'AGCTAG
TITTTGAATCG
ATTATITTAG
ITTTCCCCAAG
ATTATI'CAAA
AAACGATTAA
AAATCTTGCA
AATCGCATGA
TGATCGATCT
TGCAGGACAT
AAITAGAGGT
ACCGCTGCAA
ACCAGI'AGC
ATTCACTTTC
AAAGAGAAAC
CGAGAXTTA
GGCGTATI'CT
CCCCTTAAAA
CGTGGGGTAT
GAATGTGGAA
GGC'TTTAGAA
AAATTACCTC
TGTTTCAAAA
TGAAAATCTT
TTI'ATGGGAT
CGCGCGATCT
TI'TACGCGCT
GCATI'GCAAA
GTITATGGAT
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 969 INFORMATION FOR SEQ ID NO:116: SEQUENCE CHARACTERISTICS: LENGTH: 30 base pairs TYPE: nucleic acid STRANDEDNESS: double PCT/US 96/091 2 0EA/US 1 8 DEC 1996 180 TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...30 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:116 ATGGAACACC TTACAAGGGG AATTAAGCAC INFORMATION FOR SEQ ID NO:117: SEQUENCE CHARACTERISTICS: LENGTH: 153 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...153 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:117 GTGGTTATCT TAGGCTCRCA TGGCAAGGAA GAGTATTACG CTAGCAAGAT TGCAGCCCCC ATTTTTAAAG AAATCACCGA AATTTTAGTG CGTTACAATT ACCTATCGCC CTCTATTGCG 120 ATTCAAAACG CTTTGGAAAA AAACCGCTTA AAA 153 INFORMATION FOR SEQ ID NO:118: SEQUENCE CHARACTERISTICS: LENGTH: 237 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori PCUS 9 6/O09 1 Z jrENUW 8 D E 1996 181 (ix) FEATURE: NAME/KEY: misc -feature LOCATION .237 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:118
ATGAAAAAGG
GATGTTAAGG
GCTI'TAGGTA
ATGGCTTI'TA
TI'ATIGTGGC 'TrTAGGCGT' TTGGCGT'CG CTCI'GTAAA AGGFI'GTGCC GCTTGCCATG AAAGCAAAAT CGTTAACATG ATGAGCGAAA AAAGCGGTGC CAACAAGAAT CCTGTCATGA
CAAATGTTT
GGG'ITAAGTr
AAGAGATA
CCCGCAAGCT
AATGGCAACC
TGAAAAGAAA.
AGAGGATCTTI
AAAAAAT
INFORMATION FOR SEQ ID NO:119: SEQUENCE CHARACTERISTICS: LENGTH: 285 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .285 (xi) SEQUENCE DESCRIPTION:-SEQ ID NO:119
ATGGGGATTG
CATGCGAAAT
CAAAAATGCA
GAGGATITTA
CGTTTGATGC
CAACCAGTCT
TTATGAGCTT
TAGAGCTCAA
AAGAGGGCT'
ATTTATTGTA
CATCAGTGAG
GGGGGAGCT'
TGAAGCGATC
GGA'TTFTA
TGATGCCAGC
GTTTCTAAGT
GGGTGCTATG
TGTATTTAG
GAAAAACACA
GTGAAAAGTG
TTTATTACGC
CGAGCCATTA
AAGACGATAT
TCCAAGAGT1'
AGCCT
TrTAAAATAC
TI'CGTTGTGG
AACCTTGAAA
AGGCTATGCG
INFORMATION FOR SEQ ID NO:120: Ci) SEQUENCE CHARACTERISTICS: LENGTH: 462 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .462 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:120 AK&FNDED SHEET PCTILS 9 6/ 09122a iPEA/US 18 8DELG1996
ATGCACCT'A
CAITI'AATCC
GGCGATATTT
ATTGATrAA
GATTCCA
CCCGCATTAT
ACTAAAGCGT
ACTTTTTTA.A
AAAGTGGGGC
ATACGCTTAA,
TCCATGT1'CT TCCATGCGTr TGcGTTI'GT TCcAGTATGA
ATGAATITTTA
ATTTATI'AAG
TGTTI'ATC
AGAACTITTA
TGTGGGCTAT
GAGCGAAATI'
ATTCAATTCC
TAACAAACGC
CATCACGCAG
TTrI2AAAAC
TCTGATGCGC
AGCGCCAAAC
TTIACCCCTAG
TCACAAGTCT
AAAGTAATGG
TTTTIGCTAG
CTCACTI'CCA
TI'ATACCCTI
ATI7'rFTG'CC
CCCCGCAAGT
ATAAAGAGCA
TTTACT'ITGA
TTTGAGCG
CCCATGGGGA.
CT1'GGGCTAG Tr
CAAAAGCCCT
crIWITrCATG
GCAAAAAATC
AGGCAACCAT
CCAAAACCAA
TTTAI'CATC
ATlTI'ITITA INFORMATION FOR SEQ ID NO:l21: SEQUENCE CHARACTERISTICS: LENGTH: 939 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genolnic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1 .939 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:121
GTGCAACCGA
IT1'TAACCC Tr'rGCCGCAA
GCGTGGGTTT
AAAACTTTAG
AATCAAGGGG
GGGCTTTATG
CCC CCTAAAA
TACAAACAAT
AACACCCCAT
AAAGAAAACC
CCTACCCCCT
TCCCCACACC
ACTAACCCCA
AAAGAAACGC
ATGACAAAAC
TGAAATCTAA
TATCTI'CATG
TCAATAAAAA
TATTCC 1771
GGCATCTATI'
AAATCGGCAA.
TGCTGATAAT
GCGTTTA.
GCTTGCAGGC
CAGATITCTCA
CTATTGATGA
ATAACACGAC
CCCCTACCCA
CTITAAAAGA
CCACCACACT
RGAAAACCAC
AAAACTTTAT
GCTAGGTAAT
ATATT1TGGG
ATACAGGOCT
AGGCATTTTA
CAGCGCGCGT
GCTI'ATGGTA
CCC'ITATATG
CTTTAGCCCT
AAAAAAAGAA
AAACCACAAC
CTTAAATAAT
TI'ACACCATI'
ACCTAAGCAA
CAAACCTATC
AAAACCCCTA
TTAGCTTTAA
AGCGGTITAG
TATCT1'TCAT
AAAAACCCTT
TCTTrACTCT
TGTTTTTAC
GTI'ATCTCTTI
AACAAAACAC
AATTT1 9
AGCC
ACCAACAACG
ACCCCTAACG
TCAGAGCCGC
TACCCTAAAA
GAAACCAAAG
ATGCCCATAT
ACCACCCCA
TCATAGGGGT
TGGGGCGTT'
TGATAAT'I'
TI'ACAGAAAT
rrlTGCAATC
ACCCTTAT
ATFI'AATTT
AAAGCCTTr
TGAAAAAAGA
ACAAAGAAAA
AAGAATCGTT
AAGAAGGCT1'
GAAACCGAT'
AAAGAGAACC
ccGcATCCAC
TTTAI'AGCG
TGGGGTGTGG
ACCCTATTIG
CGTTITAGAA
TAGCCTGTTG
ATTCAAACTG
AAAAGAGATI'
GGGTITTGAA
AGAAAACCTC
TT-TAGCGATC
AGTCCAAAT'
TGATGATTITG
CACGCTAAA
ACAGAAAATC
120 180 240 300 360 420 480 540 600 660 720 780 840 900 939 INFORMATION FOR SEQ ID NO:122: SEQUENCE CHARACTERISTICS: LENGTH: 957 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO AUF~wwE SHEET PCTIU 96/09122 IPENUS 18 D EC 1996 (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1 957 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:122
GTGATGTTAA
CTCACTTAT'
TTAAACAGGC
TTAGACGCTA
GAAGGGCTAT
AGCGATAAGT
TATCCTTCTA
AATAACGATC
AGCTCGCCFI'
A'TTCTATCA
TGGACAGCGA
CTTIAACCC
TTGGGTAAAA
GGCTCTATCA
AGCGAGCCGG
ATCAGrI'TGG
GTAGAGACAT
TG=rCGCA
AAATCAGTAA
AGGGCATGCT
TAGAGCATGA
ATTA
T
ITA
AAAAAGGGAA
TAGCGTTI'GT
CAAAGTAT
TGCTCACTT
TCGTGCATT
TAGCTTTAGC
ATAGCGGGGA
TTATCGCATI'
ATAAAATCAC
CGATATGT
TGTCCAATAT
CAATATCCGC
GATGCAAGCT
CATGCTTAAG
rFITAACAGAA
TCAAGCCGTG
CCATITGGTA
GGTGTGCTI'G
TAAA.ACTT
AGTGTCGCTG
TAGCAGTTI'
CACCTITGAT
CAACCACCAT
AGCCATTGAA
TTATGCGGTG
TAAATI'CGCT
TCCAAGATCC
AACCACCTTC
GAAATCAAAA
CCAAGCCAAT
GGGATI'GAAT
AATGAAAAGC
GTGAGCGCGT
CAAATCCC T
AGCGAAGGGA
CTTTTATTCG
GACATI'AAAG
TTGGTCAAGG
GCGATCCACC
GCGTTAATGC
TATI'GGCTA
TATAGCGTGT
GCACCGAGTT
CTGAAATCAC
TGGCAAAAAG,
TTAAAGAGCA
TAGAATCGCA
GTTCATT
CTI'ACCCGGT
TGAGGGTGGC
GCATGGTCAT
TGAAATGCAT
AAGTGTTCCA
CGA'ITTI'TGA
GCACCATGAT
TCGTGTTITAA
TCGGCGTGGC
TGCCCAAACG
ATACGCCTAC
TIWIGGATTAT
'IT'I'TTTGTT
GGGGCATAAG
TGTCAGTIT
AACCGACCCC
GTATGATCAA
GATTGAAATC
GTATITTATG
TrCTAGCTI'
CCCCATG
AGAAGAAGTG
CAGGTrTTA
ATTCAGCGTG
GGTGCTIITG
AGAACGC
120 180 240 300 360 420 480 540 600 660 720 780 840 900 957 INFORMATION FOR SEQ ID NO:123: SEQUENCE CHARACTERISTICS: LENGTH: 354 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (geriomic) (iii) HYPOTHETICAL: NO v) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .354 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:123
ATGGTTATAC
GGCAGGCATT
AATAGAAGTA
AAAACCCGCT
CGCTTIATT
ATGAAAAAAT
TTGCATCTTC
GTGCAGTTGC
GTGGGGAATT
TTGGAATTTC
TIWITGTATGG
CAAAAGCCGC
AAGCGTGTAT
'FrGGTTATTG
TGTAGCAGAC
TArI'GTGAGC
TTGGCTTTA
TTCTAGGA
TITITCTCAC
ATGCCTGAAC
ATGGCGITG
GGCGTITCAC
TTAATTGGTG
ATTGGTCTIT
TTC'FrGTCAT
ATTTGATTGG
GCAAAAAAAG
TATT1GCTI'GG GGCTGTCT1T
AAGGAATAGG
TACAGCGGTT
GTGGTTTG
TAAGATTI'
CGC'FTACCAG
TA
120 180 240 300 354 INFORMATION FOR SEQ ID NO:124: SEQUENCE CHARACTERISTICS: LENGTH: 276 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular a a tr& i n r rs f- PCTUS 9 6/@091 Z a IPEA/US 183DEC 1996 184 (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .276 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:124
ATGTTIAAAA
G TTITTGGG
CAAGTGAAAG
AGCGAATGCT
GCTGGTGAAA
GCAGATTAAA
ATGTCATAAA
AAAGGGAAGA
TTGAAAAAGG
GAAATAGAAG
TTCATGGATI'
ATACAAAATA
ATAT1'ATAAA
AGGCGATAAA
AATG'FrAGAG
TI'AIAGGGA
GAAGATTTGC
AACCACATAG
GTGGATI'GCT
ATTAAA
TTI'AGGGGT
AACATGATCA
AAGAAGC'I'I'
CGGCTGCTAT
TTTAGTGGTG
TI'ATCTATCA
GAAAAAGGAT
GAGAATAGCT
120 180 240 276 INFORMATION FOR SEQ ID NO:12S: SEQUENCE CHARACTERISTICS: LENGTH: 414 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc-feature LOCATION .414 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:125
ATGGTATTTT
GTGTITTGA
GCATGGATCA
ATITTI'ATGA
GITCAAATAG
GCGGAATTTA
TI'TATAGGGT
GGGGCGCTGT
ACAGC'ITGAW
AAAATGAAGC
TGGGTTI'GT
TGCCTGCTTA
TAGATG'TTC
GCGTGTICAA
TI'TCTTI'A
TTYCATGCTI'
CCACACCACT
GTGGCCTITr
TCATGGGATC
TATCCATTI'
ACTCAGCTCT
TGGGATCGAA
GCGGCC'ITGA
CAAATCGTTI'
GAATCCTTGC
AGTTTGCTCG
TACGCGCTTA
TTAAAGAAAG
CGGCATGGAA
GT TGGGGTC
TGATFI'CTI'C
CCTCITATI'
GGCGATI'GAA
TI'GCGATTI'
CTTGTGAAAA
GCGCTTAATG
GTITTAGGG
TTTGCCCTTIG
GCAAGTCTITC
TCAAATGCAT
TATCGTGAGT
CGCT
120 180 240 300 360 414 INFORMATION FOR SEQ ID NO:126: SEQUENCE CHARACTERISTICS: LENGTH: 762 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) Ak~cncn (%Uf~rr PCT/IUS 9 6/f091b IPENUS 18DE C 1996 185 (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .762 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:126
ATGCATGAGC
ATACTCTACA
GCCAAAATGT
GAGCAAGGTI'
GATTACAGAG
AGACAATTCT
AACCTAGCCT
AAGAGTTT
AAGTGTATC
GAATTAAAAC
AGAAAAGAGA
ATTAGTGATG
CAAAAATCAC
AAGGTTCTAT
AGCTCGCAT
TITI'GCAAGT
TIATTGAAGT
AAFI'AGAATG
TTGATTAFFI'
ITGCTAAGAC
TAAAAACACT
TACTTATI'GT
ACATTCAAGT
GA :.AGCTI'A
ATIACAGACT
A)AATCTT
AAGCTITRTA
TAATGCTAAG
TGTAGCAAGA
CATI'AAAGGA
CTTAGTGAAG
GGATAGAAAA.
CAAAGAAAGC
CTTIAGACTAT
AATACTTGGG
AGAAGAGCAA
TATTAAAAAG
AAAATATITC
AACGCTTTAT
GGCGRACAGG
TCTAATAAGA
ACTCTAATAA
AAACAAAGAT
AGCAAGATGG
AGGCGFI'ATG
TI'ACCCAGAC
AAGCCAGCTA
GGACFI'AGAA
AACTACTCTA
AGTI'TGTI'AG
AATGGAGCAT
AATTTATCCC
GAGCTAAAAG
TTGCCCTAGA
AGAATGTCAA
ACI'GTATGT
CTA.GTAT
GCTITGATIT
ATIAAACGA
CAAGCTTrGA
AATGCGAAGT
?TTAATTCA
AACCAAGCFI'
ATCTCTITAA
CT
ATTATTATAC
TAGACA'FrAC
TATATITAGAA
GTATCTTIAAA
GATGTATTTA
TACGCTTAAA
TAAAGACTI'A
AAAACGCAAT
GFI'AAACATA
AGGTAAAGGT
GAATGCFI'GG,
AAAGGATAAG
120 180 240 300 360 420 480 540 600 660 720 762 INFORMATION FOR SEQ ID NO:127: SEQUENCE CHARACTERISTICS: LENGTH: 555 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc-feature LOCATION .555 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:127
GTGGTCITTTA
TI'ATACTI'AG
CCTAACGCTA
AACCCTI'TG
ATGGTGCAAA
GTGGCTAAGG
AACGCTCCCA
TCGCCCCT
CATGTTAAAT
AAATI'TAAG
GCGAAGAACC
GAAAAGGCGG
CGCTTAAAGG
GCTTAGACGA
ATAACAGCTA
ITITAGCGAG
ATAGGCAGTA
TCATT*TYCAA
FI'TATGGTIA
CAAATATAAA
TGTT'I GAGA
CACTAAAGCC
ACCTI'TGCA
TGTGATTITI
CGATGTGAAG
TTACCAAGAT
AACCACTGAA
GGGGTGFTT
GACAATTTCA
AATGACGCTA
GAAGGCTTGG
GAATACCCCT
ACCCTAGATA
TITAGCITI'G
GTI'AAAAAGG
AATAAAGAAT
GTrCCT~
T
AG
CGCATITTTGA
TAGGGACTT
ATCTCATTTA
TAATCGCTAA
AAAGAGCGAG
ATACGATAAT
CGGTTATCT'
TGCCCCTCAT
GGCTACGCAT
ATACGCTAAC
TGATAGCCITT
TGACACT'IA
AGACGCCGAA
ATTCAGCAAT
GAAATI'AGGA
AGACAAGCAC
TFI'AGGGCAG
120 180 240 300 360 420 480 540 555 TTGCAGATCT TTCC 'k)INFORMATION FOR SEQ ID NO:128: MOT/U 9 6/O0912~ IPENUS 1 8 DEC 1996 186 SEQUENCE CHARACTERISTICS: LENGTH: 198 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE- NAME/KEY: misc-feature LOCATION .198 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:128 GTGGCCATGA TAGA'ITGCGC GAT1'ATTGGA GGTGGTCCTG CAGGTI'GAG TGCGGGGCT TATGCCACTA GAGGCGGTGT TAAAAACGCC GTTFI'ATITG AAAAAGGAAT GCCTGGGGGG CAAATCACTG GCAGTAGTGA GATI'GAAAAT TATCCGGGCG TTAAGGAAGT GGTGAGCGGA ?1'GGATITCA TGCAACCA INFORMATION FOR SEQ ID NO:129: SEQUENCE CHARACTERISTICS: LENGTH: 546 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylonl (ix),FEATURE: NAME/KEY: misc-feature LOCATION .546 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:129
GTGGGGAAAA
TI'CACCGAAT
AAAGGCGAT
CAAGCTATAA
TCTAAAACGC
CATGGCATAG
TI'GGAAAAAA
ATCATCAGCT
AGCATGGGGA
AG'ITTA
GCTI'GAGATA
TAGAGCCAAC
?IGATTCAGG
GCGCGATCAG
CCATGAAGGA
GCATTGAAGG
GAGCG ETAT CGcTPiI-1AAT
GCAGTCAAAA
CAGCTTGAAT
AGGTCTCACG
GCTAAAATCC
GAGAT1'ACCC
TATTGAAAAA
GTGGTGGCAA
CATTGTGCTC
GGTGGTGATG
AGAAATCCAA
T1'AGATCTCA
CTCTCCCCCA
TATGACATGA
'FrAGGGCTTT
TTACGCAACG
CAAAACGGGA
ATGCTCATTA
AACAGGCGTA
AAAACCTTT
ATCA.AAAAGC
TCATGAAACG
GCTACATGTA
ATGATGGGGT
CTTTAAAAAC
AT1T1'11CTC
TTTIAATGGC
AAGAAATCGC
TTTA'TrGGG CGAITTG7
CTTTACTATC
TGCGAGCCTI
GCATGTCTAT
AATCAACCAC
GGCGATGGAA
GTCTT~TGAAT
CCTACTCTTI
TAATATCA IT 120 180 240 300 360 420 480 540 546 INFORMATION FOR SEQ ID NO:130: IN SEQUENCE CHARACTERISTICS: AMFNnlFI QWCC~T POT/US 96IG9i i IPEA/US i 8U0LG1996 187 LENGTH: 741 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc-feature LOCATION .741 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:130
ATGAAAAAAA
ACCAAATGGG
GATITTTGAAG
CACACGCAAG
TTITI'CACCC
GGGCATGACT
AATAAAACCA
GTGTTAGCGA
GGCATTCAAA
ATCAATTACT
TGGTTTGTCA
CGCATGAAAA
AAAAGCTCGG
CTI'rI'GAT
ATTATAAAAA
TGTGCAAAAG
ATAAAGCCGA
ACCATACITI'
ATGTGTTGGA
GGCCTTTGAG
TTGGI'ITrGA
AGAAACAAAA
ACCATITI'AA
TAGAAGAACC
ATTCGCCCAA
CTGAGACCCG
CGCTITAGCG
TAAAGAAAAT
CGGTAAAAGC
TTI GCAA'IT1C
AAAGGCTTCG
TAATGTGCAT
CGCGCATTTIC
AGAAGGGAAA
TCTTAAAGAG
CGGCTCTC TC
TTTGGAAGTI'
CCAACGCCCC
CTTACGGC1'
GGCCCGCACC
CAATCGCCCA
AAATACGCCG
TrI'GAGCCGA
TTCCACGCCC
GTGCATAAAG
GAAAACCCCA
GTGGCTTI'AG
ACCGCTCCTC
TCTGCCAAAC
GTCCAGCCTG
CTC'ITATAGG
GCTGGGACAA
TCAACATI'GA
CTTICTAAACC
CTAACCACAT
CTATGGAGTI'
ACGCTAAAGG
ACCTI'GATCC
ACGCTFI'CTT
CTTGCACAGA
AATI'GGCTGA
ACTACAACAC
CGCTGAAAAC
ATI'GCACAAA
GCATI'ACTAC
TAAAGCGGTC
CAATTATAGA
?I'TAATCAAT
GCGTTTGTTG
TATTTTAGAA
GCCTAAAAGC
GGGGGTGGCA
AATCAAAAAA
CGTGATCATIT
INFORMATION FOR SEQ ID NO:131: SEQUENCE CHARACTERISTICS: LENGTH: 1266 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii).HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION I. .1266 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:131
ATGAAAXTT
AAAAACCATA
GAGGGTTFI'C
GTCAGCCCTG
GAATACGA T
CITATTGGG
ATGAAGTCAA
TITGCTACCC
OCATTAGTTT
ATAI'GATAG
ACGGGAAAAC
GTGGGGGGAA
GCATGGAAAA
ATTTTTTGAT
TAGTAAGGAT
CACGCACCCT
TTTGTTTGAT
CACCACGACC
TATCGGCACG
ACCACTCTAG
GATAAAF1'CC
TTAACCCTA
TTAGTCATGA
CATTCT'FTCA
CAAATGCTCA
CCCTTGATTG
CCCTAGGGCG
CTGCATI'ITT
ATGATTCCCA
AAGCCAAGCA
CGCCTACGAT
CCACACTTTT
AATI'GTrIGA 7*I'r1=AAA
TAAGGATAGC
ACTAGAAATC
TTTAATGAGSC
GATAAGTAI'
AGAAGATT
AAAACGATCG
CCCTTGTGGG
TTAATCTACT
AAI'A'FTGA
CTCCCTTTAA
TTTGACAAAA
AAGGGAGCGT
ATAAAGAAT
AAAATCGGCT
GACAGCAAAG
AAAATCCATI'
GAGI'TAAAA
GCCTI'AGCGT
CAAGAAATTA
AGTTTGGATC
AAAGAT
TGcTAGAAAC TGCTcATCAA
ACGCTAAACT
AATTCAAAGA
GCGAAGAGGT
eTTTATTAGA
TAAAATGGCA
CGCATAAAAT
CCACGAATAT
TGATTTAGG
ACTATAAAAT
TAGAAT1IAA A.AGCGI71i-
AATTTTC~
T
rC
AAGCTCCTT
TGGGAAGCC
cAAGG TI'A
ACACCCTA'T
T1'TAGAGTGT
CGCGGCTTTA
AGATI'ATAGA
GGAAGAATT
TGATGCCACC
GGGCGATATT
AAGCCT'ITAT
TGTFI'CTIGT
ATTACAAAAT
GTATAAAGAA
TCTI'GCATT
GATCATITGA
ACATTGATGC
GTI'CAAAACT
TI'AAAAATCC
GCCCTI'AG
GAAAACGCCC
AGGGATAAAC
T'TACAAGCCC
A&AGGGGTCA
GCCATAGGAT
CAGGTTGT
GAAGTCGCT
AGGGGTGAAA
ACACTAATAA
CTrGGCATTG cTAAAAcTTC
CGCAAGCGCA
CTTCTAACGC
'FTrATGAGCA
TTAAAAGACT
AAGGGCGTTI'
TAAAAACCTT
ATTAACCCC
CAAGCGCTI'C
TGAAGTTAGA
TGCTTTCACC
AATTCAAAGC
GGCTTACCCT
CAATTTrGAA
GCTCGCTATC
AAAAATCTTr cCTrT t TrI'T
ATTITTTAAAA
GAACGCT1TTT
GTGGGTAGAT
TAAAAACCAA
CTI7rITGAA
TATCATACAA
AAAhGCGGTI'
TAGCGCGGCC
GTTTGTITTTA
480 540 600 660 720 780 840 900 960 1020 1080 1140 1200 1260 1266 INFORMATION FOR SEQ ID NO:132: Ci) SEQUENCE CHARACTERISTICS: LENGTH: 162 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (gerlomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .162 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:132 ATGAAAGAAA TCA'IGTCGC CC'ITGTGGGC CAGCCTAATG AACGCTFI'GA GTAACSCCCA TrI'RAAAGTG GGGAA TTA ATGGA.AGTGA GTTTGATCCA WAAAGATCAT CAARTSWYTM TGGGGAAATC GTCCTTAATC CCGRGGTI'AC CGTGGATAAA
TC
INFORMATION FOR SEQ ID NO:133: Wi SEQUENCE CHARACTERISTICS: LENGTH: 333 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori 4- (ix) FEATURE: NAME/KEY: misc-feature LOCATION .333 ~AINfl~Jf~ ~4F-~f POTIUS 9 6/ 0912]Z IPEN/US 18LDEC 199&.
189 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:133
GTGCATCGTT
CTATCTCGCT
AGTGCTTI'AT
TI'AGCCTIT
GCTAATAAGC
TCTTTAGTGA
TTTCTAGAA.A
CATTAGTGAG
TITCTI'TAGT
CTITTTCTGT
GTGTGTTITC
GCT1'GTTATT CCCATGCGCA TCTTGCAATC CGCGGTAACT TGGTGG'ITGA.
CAGCTCGGTG AITITATGGG TGTCAATTCT CT1TTrTCTl' TTTAGCTAAA ATGTCTTI GTTTGCCAT AAT
GCGCTCGCTC
GC7TGTCGT
TTAGCTCGGT
CAGTCAGCCG
CCGTITTTCAG
TTGT1'CGAGA F1'CGGTGGTT
GTTICTCTT
ATCTCT'GGCT
TTCTCCTTT
INFORMATION FOR SEQ ID NO:134: SEQUENCE CHARACTERISTICS: LENGTH: 411 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .411 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:134
ATGCAAAAAA
CGGTTTAAAG
GCTI'CAGI'A
AGCGTGAGCA
TTATI'ACCCA
TTrCATATCG TTGG71I'rr
TGGGCGTTGT
AGGGCGTGT
AAGAATTGAG
TGCTTGIT
TTCCAGCC'T
CTTTGCCAAC
TCATGITI'
CTCTTAI'CC
TITGATI'GTG
TGGGGTAATA
G ITGGGGCG
AGATGGGGCG
GCCCATACAA
AGGGCTTT
GTGTTI'CAAG
GATCTTTAA
GGCATTGTGG
TTTTATCTA
CAAATGCTAG
AATGCG'ITGT
AATGACATA
CG'TTTGAAA
GGCGTTTGAT
GGGCGTTAAG
TCAATCTAGG
GGGTCGTTI'
GGCTAGTGGG
CTCGTITGCT
GGCTTI'GAGT
TATGGGGAGC
CCATGCCAAT
GA'TITI'AAAT
TAAAAATAT
GGTGGGGTITr 120 180 240 300 360 411 INFORMATION FOR SEQ ID NO:135: SEQUENCE CHARACTERISTICS: LENGTH: 372 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY; misc..feature LOCATION .372 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:135 POUS 9 6 /0912Z.2 IpEN/US 18 D EC 1996
GTGATGGCTT
GTTAAAAGCG
AACATGATCA
CACATI'GCTA
GATGGAGCGG
AAAAAGCTT
ATTGAGTCTC
TGTI'GAAAAT
TTGTGTTGCC
CCTI'GCTI'CA
TCAATI'GGGG
TCTTrATI'AA
TAGAGGACGC
Tr
TAGTGTGGTA
AGGAGTGGAA
GGCGGGAGTG
TTATGCAGAA
AAAAGGATCA
AAGCTCTGAC
GTTCCTGAGG
GGGGAATI'TG
GTrGAGATTG,
GTI'ACTAATG
GATGACAGAG
AGGTTAGCGG
GGGAAGTrA
GGGTGCTI'TA
AAACCGAAAA
AACGGGTGGA
ATGATGCTAT
TCTCTAGCGT
TACAGGAGAG
TGGGCATAGC
CCAAAAAGAG
TATTTTAGCC
CTCTAGGGCT
GCTGGCTAAG
120 180 240 300 360 372 INFORMATION FOR SEQ ID NO:136: SEQUENCE CHARACTERISTICS: LENGTH: 258 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION I1.. .258 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:136
ATGTATTCCT
TTTATCGACG
TATAGCGATT
TCCCATGCGA
ATATCACAAG
TGCTCTI'AGA ITTGAATAAA AAGACCGCTC ACAAACACAT CAAAGAAAAG GGCTTGACCA TGGAAGAAGC GATTCGTITA AAATGCGAAT 'I GTCCAAAA CGCATCGCTG GGCTTGATIT
CGATCATI'
TIr~AGGCAC
CGCCCACTCT
ACTTCATTAT
CGCTCTI'AAA
AAGAGGGTT
TTTAGAGCTT1
GGAGGTGAGC
ATTCTCACCA
INFORMATION FOR SEQ ID NO:137: SEQUENCE CHARACTERISTICS: LENGTH: 324 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .324 (xi' SEQUENCE DESCRIPTION: SEQ ID NO:137 h3AAAACGA ACTTTATAA AATTIAAATTA CTATT'GCT' GGTGTCTTAT CATI'GGCATG ~AACGCTC CGCTTAACGC TGACCAAAAC ACGGATATAA AAGATATTAG TCCTGAAGAT Il-~r,~ PUTUS 9 6/O0912 Z [pEN/US 18 DEC 1996 ATGGCGCTAA ATAGCGTGGG GCTTGTI'CT AGAGATCAGC GAAACCCTAG AGCAAAAAGT GACCATACTC AATGACTATA AAGTTTGACG ACATAAGTTT AGGGAGTI7rC CAACCTAATG ATGT GGGGCA TTCAAAATCT TCTM
TAAAAATAGA
ATGATAAGAA
ATAATCTAGG
GATCCCTAAA
TGTTAATATC
TATCAATGCG
INFORMATION FOR SEQ ID NO:138: SEQUENCE CHARACTERISTICS: LENGTH: 720 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .720 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:138
ATGA'ITGATA
TrGTGTAG
AAGCCATGCT
GGGTTGAAAG
GCTTI'GGAGG
AAAAAAAAAG
AC'ITATAAAG
AGCGCTCATG
GATTrCTT
GCTCATGAAG
CAACCCCTAT
GATTATTTA
SCCTITGATGG
GAGGCGATGG
TTGGGGTGAG
ATTT1CTIACA
GCCCTATTGG
CTII'AGGGGT
GCGATGGGCT
GGCCCATI'GT
TAACGCAACG
ACGCTCTI'GT
ACATI'CAAAA
AAGTGCTI'AA
GGCAAAAGAT
CACGATI'TTA
GAI'GGGAAT
AGATCTCAAG
AAACACTCT
TTTAGACATC
TATCATTGCC
GCATGCTTTA
CCC'IITAGTG
GGTTATTGAT
AAGCCCCACG
AGAAAAGCTG
GCACAATI'GA
GGGGCTITAA
TTAGGGT TTT
CAAAACAGGA
TITTATGCGA
AAAGCGTGCG
ACGCCCCTAG
AGCCAAAGCT
TTAGGGGCGG
GGGCAAGCCA
ACCACCAAGC
TTATGGGGGG
TAAAAAAAGC
GAATGACGCA
TGAGCGCGGT
TCAAATTAGA
TCAATGAAAT
CGGGCCATAC
GCTCAACCGC
ATXTTFAAC
AATTTTGCTT
CCTACGATT
TTACGCGTr
TGCTCACAAT
TGAATTGAAC
AGAGCATITG
CGTGATCGCT
GCCCTrAAC
TTATAATTTG
GCCCTI'GTGC
GAGTITIGC
AAAAGCCAAC
120 180 240 300 360 420 480 540 600 660 720 TCI'TACAAAA AAATTCAAGG AAAGCCCTAA CAAAAAAAGA.
INFORMATION FOR SEQ ID NO:139: (i).SEQUENCE CHARACTERISTICS: LENGTH: 549 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .549 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:139 POUS 9 6/O091 2 IPEAUS 18 DEC 1996
ATGATAGTGG
GTGCAAGGGG
GGCCAAAAAG
GGGTTITAG
GGGGGGCGTA
ATCGCTACTA
GATAAGATCA
AATGAAGTCT
TTAAAAACCC
CTGCGCTCT
GTITGATAGG
TTGTI'I'ATGG
CGCGT1'rGAA
AAGAGAGCGA
TCGCTTTAGC
AAGAAGTCAA
TGGTGGAT
TI"ITAGCCCT
TAAAACCCCA
GGTTGTGGAA
GGTGCAAGIT
AATCTI'ACAA
AAAAATrCTC
CATI'CTITCA
AAGACTCCAG
GArITGGC TIT AGAGAGTTT1G
TCTCAGCATA
AAAATCTCTC
TcTATGCGAA
GTGATTAAAG
TTTGAAAGGC
AGCI' ITCGC
CAAGTCCCAG
TTCATTCAAG
GGCITrAAAA
GAGGCAGCGA
CTI'TAGAAGC
CGGCTGCTT
AAGATGCGCA
TITI'GAAAAT
CGAATGAATT
GCATAGGGAA
ATGAAAACAG
GCGCTGAAAT
?I'AAAGAAGC
GCATATAGAA
GCTCCAAACG
TCTITATAC
CAATGGGGTA
TGAAAACATI'
AAAGCTCGCC
ACCCGCGCGC
CAATCCAG'I'I
CTTACAGCAA
120 180 240 300 360 420 480 540 549 INFORMATION FOR SEQ ID NO:140: SEQUENCE CHARACTERISTICS: LENGTH: 462 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .462 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:140
GTGGGGGI=
CAAATACGCA
GCCTCTI'CTI'
TTGTTGGACG
AAAAATGACG
ACAGACAGCG
ATT~CAAAAAA
TTIGTTTGTCG
TGTTRGCGTI'
TGCAATACAC
TAGAGCCTTT
CAGACAACAG
CCTTAATCAA
CCCCAACTAA
TCTI'TATCCC
CGCTAATAGC
GTTTTTCTT
CGCTGATGCG
AAAAATCTI'A
AGTCAAGT
AACCCCTTAT
CCGCTTAGGG
CCT'FrATAAA
CATGTGGCTT
TATGCGAAAA
ATCGCTAAAA
GAAGAACGAT
TCTAATATCG
ITI'GCGCTTA
GTTTCTAAAA
ATGATAGGCT
TATAAAATCC
ATAACCTI'T
GCCTITI!AGA
TCAAAAACAC
GGGTGTTTGT
AAAAACAGGG
TCATTATTGC
ATGTGT'FITT
CA
GGAAAACACC
ATTAAATAAT
CCCC
1
ITTGTT
GGCCTCTTTT
CTITTACCTC
AGAAGAAGAA
GGGCGCGAGT
120 180 240 300 360 420 462 INFORMATION FOR SEQ ID NO:141: SEQUENCE CHARACTERISTICS: LENGTH: 864 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: FA NAME/KEY: misc-eature A a 1^ PCT~AS S6 /I091 92 193 LOCATION .864 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:141
GTGGTAATAA
CAAAAAAAAG
GATIATGAAG
GAAAGAAACG
TCcGTGATTI AAcGATCCCA
AAGCCCAA.AA
CCCCTAAAAA
CAATCCAAAG
ACTTTCACTT
TATGTI'TATA
TTAGAAAAAA
ATTITCAAAGT
AAAGCCATCA
TTTI'AGAAT
TGATITTAGT
CCCA.AGAGCA
TCTITAGCGA
C 171 IT CCA
TACTGAATGA
ATAACAATGA
GAAAAACAAA
ATGGGGATAT
CCTTGAAGCG
TI'AATGACAC
CCACCAATAA
AGAGCGATAA
GTCAAATGGT
GTATI'GATI'
GTC'ITAAGGA
CTGCT1TTTTA
AGAAAATGAC
AACGATTT
ACTGACTAAA
GCCAAGCGAT
AGACAACGCT
AAACCCAAAA
TATCATGAGT
TI~TTTAAAA
TAAAACGCAA
CGGTAGCTTG
TGTTTATACG
GTITAAAAAAG
GGA'TTTAA.A
AAGT
GCTTGCTCGC
GGCTCTAAAC
TTACAAAACA
GATGAAGACA
AATAGTGAAA
AATAATAGTC
CTCATTGAAT
AAAGAAGGGG
GATCAAAACG
ATCGCGCAAA
AGTTTAAGGC
ATAGAGAATA
CATICAACCG
AAAGAGCGCT
AAGAGAGCTT
GCCCCAGCTA
TGGTGTATCA
ATTC TTAA
AAAACCTACT
AAAAAAATCC
ATTCCCAACA
ATCAATGGTT
ATAAAGATCG
T'rAAGGGCAA.
CYTIT'ATGA
AGGC'TrAGA
ATAAATTAGA
FI'AAGAGCGA
TATCAAAATG
TGTGGATTCG
GCCTATAGAG
CCCTGAAAAT
CTCATACCCA
GI'CC'TrTAC
AGATCTAC
GATAGAAATC
CCAGATCCAA
AATTTCTTCG
ATCGTIrT'IG
TACTATGGAG
CAGCCAGCAT
TACGGAACTC
120 180 240 300 360 420 480 540 600 660 720 780 840 864 INFORMATION FOR SEQ ID NO:142: SEQUENCE CHARACTERISTICS: LENGTH: 1260 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc-feature LOCATION .1260 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:142
ATGGCCGCQTC
GCTGTCATAG
GCAGATGGGC
AAAGGAATTG
CTTTTAATCC
ACCTTTAA
TCTGATGGT
GAAAT7"=I~
TATCAAACAA
GCTAATATTT
'TCAAATTA
ATTTTAGGAT
TTAGAAAAAA
CAGACTAGAG
CCITTGTTGT
GGAGGGAGCA
ACATTTATTC
ACGGATGCTA
ATAGCTGGAA
,VGACGCAA
CACTACTTGC
GAGTGGGTGC
TITTATAGTGA
GTGAGCCTTT
TTrGTAI'C
TGCTTTGT
CTAGTAGCGG
ACACGCCTGC
ATAGTGCAAG,
CATTCCATGT
ATAATGGACT
TAGAATTGI'
?I'ATI'TACTT1
GTTTTAGT
TGCTATTACT
ATGAAATAGT
AAAAAGTCCC
AAAGCTI'CAT
GTCTT1AAGAG
AATCTACGAT
GAGTGGGTGT
TCTGCCCTTT
TTACTTGTAT
AATTCTTGGG
AGCCAATGTT
C'FITAAACGC
G'TrGTAGGA
TAATGGTCGC
TAACTTGCTA
AGAACACAAG
CAGACAAATT
ATCGCTAAAA
TTTrATTGTrC
GTCTI'TGGTT
GTCT1'ATGTG
GTI'ATTCA.AC
GGCTAAA'TrT
CGAAATGATI'
ATATCAAGGT
TGTGGGTCGT
AAACAGCACT
GGAGACGAT
CTI'CTAACC
CCCAATAAC
TTTCATITr
ATCCAACCTT
TATCAAAACA
TACCTTTCI'
TCCAGTTTTfG
AATGCTGGGA
AATATAGACA
TTAACGAGTT
ACCCTrATTG
AAAGI'TCT
AT TTTCATGC
AAAAAAATTA
TCTTTTGCAT
GGCATI'ATTG
AACGCTATCT
GTGCAAATGG
TCAGCAT'IFG
ACGGCTAACA
GAACTTCCCA
CTTTAGTGCT
AAGATTCTTT
CGTITCTAG
'FrGGTATGGT
ATGATTTATI'
TGTACCATTA
CCTTTCAAAA
TTTCTAATGT
CGCACCACAG
TGAATAXACT
CAGCTGTf'T
G'ITATGTI'TI
TACTGCTAGG
TICATTGAC
TACAATACGC
TAGCAATAGG
?I'GGCACACA
CTAGTGCTGG
GTAGAACGCT
TGAGAGACAT
AGTCTCATAG
TGGTGCTITTA
AGTTGTGCAA
CAAGATCTTG
TI'AGGAATG
TGAAATCAAA
TGCTTTTAA.A
TCATGTAACA
GGTTAAGGAA
TATCACTAAC
ATATGAAGAC
GTTAT1'AGTT
TATGACTTAT
GTTTCAG
TT1'ACATG
AATCAAAGTG
AATTTCACTG
AGGTGGTCTA
AGCTGGAG.CC
AGAAGCTTAT
GCCAGGACAT
AGCTAGCAAA
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1140 1200 1260 PG11UGS 96 09 122Z ;t 18 D EC G19 194 INFORMATION FOR SEQ ID NO:143: SEQUENCE CHARACTERISTICS: LENGTH: 216 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .216 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:143 GTGITTAAAAT TTCAAAAATT TT~ATTGGCTT 'FrGATTATAA AACCATTCCA AACTCAATIC ACGATCAAGC TTCAAGTGRA ACCCTTATTG TTTGTTTCCA G TTT AGTGGG GTAGCGGAAT CAAAGAAGGG AT =ICCCTA TTYCAAATCT GCTCCC 'ITC TrTATAA TCAAAGCCCT CTGT'ITCTAA AGTGGGG TT CAGCCACCTT TGTAACCGCC INFORMATION FOR SEQ ID NO:144: SEQUENCE CHARACTERISTICS: LENGTH: 615 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (geriomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEM'7URE: NAME/KEY: misc-feature LOCATION 1 .615 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:144
ATGGGTAATC
TI'AGGGCATA
I*TAGGACAAA
AAAAAACGCT
TATGGCACTA
AGCAGTATCC
TCCATAGGGC
GAAGGCAT'G
77 r TGCTTr
A\TCAAGCCAAA
ATTTCTAA
TCTGGCGCT'r
TATITTTATC
GCACGCAAAA
GGAAATACGC
TITTAGGTTG
AAGAATCTGA
ITTITTAGCGT
AAAAACTCAA
ATGCGATGAG
AGATT
ATTAGGATrI'
CCCCTATATG
CTTAAGCGTT
AAATGTAACA
AGGGATCATG
GGTGCTTTAT
ACAAATTPT
TI'TATTCATA
TTGGTTrI'A
CATGGATTCT
GTTAGCGG
ACTGGGGTGA
GGT GCGGCGA GAAGCT'TrA
CTI'ATITCTG
TATTTGGTGA
ACTCAAACTT
ACCGGATGGA
ATGCCCTTIAC
I"ITTCTAAAG
CTTTAGGGAG
GTGGTGGGGG
TGTI'TATCGC
AAGAGCI'GA
GACCI'TAAT
GTATTAGTTT
TGCAGTCTAT
?I'GTITCTAG
TCTITGCCAC
CTTTCCATIT
CGCGATAGGT
TCCTTI'GTI'
TGAAATGCTA
CATI'AACCCT
ACTGAC I-Ir
TAATTTGCCT
AGGGTTACAA
GGGGATTAAA
TT I TTGGT
CATG'ITGATT
PCT/U6 9 6/O0912~ IPEMS 18 DEC 1996 INFORMATION FOR SEQ ID NO:145: SEQUENCE CHARACTERISTICS: LENGTH: 984 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular :Iii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION I1.. .984 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:145
ATGGAAAAAG
GAAAAATATG
CTTGAAGAAC
CTCAATGGAT
'rTAITI'GATG
TGGATTI'TA
GTATGCTTAT
CAAAATTTTG
AGACAATTGG
AACGAAATAG
GAAAAACTGG
AGCATI'ATCA
CTTrTCATA
TTGAACCTA
ACAGGT1'ATG
AAAGATGATG
CAGTATAAAG
TITGCGTGAG
GCGATGATTG
AAGTCAAAGC
TTTTAAAAAA
AAGTCAAAGA
GCAGTGCGGT
TGCCGTI'AAA
CCATAGTCCA
TAGCGTCTI'A
CCCACGAAAC
TITCTATGA
ATATCGCTI"I
AAGAAAAGT1'
TIGAAATTGA
ATGTAACTGA
GTGTGAAATC
ATGTI'AAGGA
CGCATGGGGG
GGAAAkACAT
TAAAGCCAAA
AGTTGGTFI'A
AGCTGATGTG
GTTCTITTTT
AGAAAAAGTG
AAGAGCAGAC
TGI'AATAAT
CATI'AGGTI'G
GCATAGCATI'
AATCAGTAAA
AGAAAGCGAA
TACAAAATCT
AATTGCGATT
TAGGAT1'ATC
GCAA
TTGCCTAAGA
GTTAAGGCTA
GAGCAACAAA
AAAAAGCGTG
CTTrCAAG
GCTCTAGCCC
CCTTATTTAG
AAGAGCATCC
AGAGAAAATA
CAAAGCGCAT
TACACTAATA
ACCCAAGCCA
AAGCGTTATA
GTTCCCCTAA
TI'AXAAGATI'
CATGTCGAGA
TI'TTAGAAGA
AAGCAATAAA
AGACACAAAG
ATATGTITACA
CAGAGCGTAA
TTATAGAAGC
TAACCTITTC
GTOGCTAATCA
TITCAAGTAT
TI'GAAGTGTG
TAAATCTAAC
ATATI'GAAAT
GAATAATI'AT
ACCCTACAGG
TAGATGAGAA
AAAAAGACCC
AAGAT1'AAAA
CGAAGAAGAG
AGAAAAAACA
AAGCACTATG
AAITGGCGAT
CATTATTATT
AAACGCTACA
AGCGCTTGTG
AAAAGAGCAA
GGATITTT~
ACGAAAAATr
ATCCGCACAA
GACCT1'TGAA
CTITATI'GTT
AAATAAAGTC
TCATATGAGC
INFORMATION FOR SEQ ID NO:146: SEQUENCE CHARACTERISTICS: LENGTH: 228 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc feature LOCATION .228 PCT/IJ 96/09122.
IPENUS 180DEC 1996 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:l46 ATGCTOCATA AGGCTAAGGT GGGCATCGTG 'ITTCAGGCGC ==I'ATTGT TGT=IACTT GAGCGCGTr TTA.ATGGTOG ATGTITATAA GCGTTFPAAT AGGGAGCGTG GTGTrCCT GTAGGGTITA AAAATATCAG C'TTGTrG GATATrGGTI' INFORMATION FOR SEQ ID NO:147: SEQUENCE CHARACTERISTICS: LENGTH: 420 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .420 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:147
TTITAGGGAT
CTT ITAAAGA
GGAGCGATCT
ATGAAATC
TTTGCGTG
CACTAAACGC
ATI'GGTCTIT
120 180 228
ATGCCGTI'T
GCTAGTGGGG
GAGAGCAACG
TACGGCA Tr
AAAACACGCT
AAGGGGCT1'A
TTAATGCTCT
TGAAAAACTG
TGGGGAAAAG
CTTCAAACAT
TAGAGAAGA
AITITTTAAA
TTAAACGCTI'
CCTTATTAGA
GATCTGGAGT
CGTCCTTAT
TGAAGTGGAA
TGAGCATGAA
CCAAACAAGC
ATCTAACGAC
TGGCTATATC
TTAAAGATGG
GCGAGCC TI'
TI'GATCGCGC
CCCTI'AGTI'A
CTATCTAAA
AGATTCAGCC
CAAAATAAAA
CTTTGAGCGC
TAGGGGCGTI'
CTTI'TAGA
TTAGCGTGAT
ACACGCTCAA
AGAATGAACT
ATARGCGTT
GATTAGTGGG
TGGGCTI'AAA
CACGGAAGAA
TAAAAAAGAA
AGCGTTATI'A
CAACGATA'T
AGCCCCCTrI' INFORMATION FOR SEQ ID NO:148: SEQUENCE CHARACTERISTICS: LENGTH: 924 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1 924 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:148 ATGCCACAAA ACCAGCTTGT GATCACCATC ATTGATGAAT CAGGCTCTAA GCA.ACTCAAA PrTTTCTAAAA ATTTAAAACG CAACCTCATC ATITTCTGT'G TCATICTTTT ATI'GATCGTG hA /396/09122 IpENJUS 18 DEC 1996
GGGCTIGGCG
AGGAATGCGG
GAGATTAAAA
TCCTISGATITG
TrAGAAAATI'
CCCCTAAAAA
ATTAAGGGCG
AGCGCTGATG
GTGCGCATIG
GTGCAGCCTA
AATAGCGGCG
GAAAAATTCC
A'ITGAATGGA
GATAAAGACA
TGGGGTTrT
ITITTAAGGGA
ACAAGCGAGA
AAATCAAAAA
TGAGCTTAAA
CTI'ATAGCGC
TrGAATCCGG
GGATTGTGGA
AACATGCGTT
AAAGCTTCAT
GCGAAAAATT
TAGCATGGGA
AGAATCTGTT
CCTTAAAAGG
AAAA'TrTTA
TTTTAGGGGT
AGAGCTTI'
GGGGGCTAAT
TCAAAAACAT
TATCAAACCC
GATCGATTI'
TITTTGTGAAG
TGG'ITTCAGC
CCAAAAAGGG
GCA~rATGAA TI GGATCAT TrGGGTTTrA
TCAG
ATcGCTAAAA
TGTATCAAA
ATI'GTGGGGC
GGGGGAGGGC
TTAGCACTCA
ACTAAAGAAA
ATCGCGCCAT
ACTCGTTCTA
TCCAI'ITATA
CAGTIGATG
GTGCGGTITI'
TTTCAAAGCG
GAAGACATCG
TGGATACGAT
AAAATTACGC
AAAAGATCCG
ATCTCTATGA
TGCTCAT'CC
GGAACCACCC
TGAACACGCC
ATGCGGGGTA
CGCACTrAGA
GCTATAGCGG
TGGGTAAAAT
CTTTAGAAGA
TCCAGCTCCA
GACAAGCGAG
CCTAGcGAAA
TGGGCTAGAA
TGAAGTGGAT
TAATGGCATG
CATTAAAAAG
TGTGTATGCG
TGGGAACTTG
TCATGTCAAT
GAAGAGCGGT
TITAGACGCA
AAATAAATT'
AGAGCATGTG
180 240 300 360 420 480 540 600 660 720 780 840 900 924 INFORMATION FOR SEQ ID NO:149: SEQUENCE CHARACTERISTICS: LENGTH: 1017 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .1017 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:149
ATGATCACTG
AACCCGrTr
GAAATAAAGC
TATITGATCA
GGTAATGGCG
AGCAGCCTTTl
GCGAAAAACT
GCTI 'GATG
GATGAATI'AG
ATCGGCGAAG
CTCATGTATA
TTTGCGGCTG
GCTCTTI'ACG
GAAAACACCA
AGCGAAGAAG
AGCCAITI'CC
CATGGCTT'G
GCTCTCACAA
ATGGCAAGGA
CCCTAAAAGA
AGGATTITTAA
TGGGGGCGTT
ATAGCGATCC
TAAAAGACTI'
GCGATGCGGA
CGATTTTATI
TCAAATGCTC
AAACCGGGCA
AAATGAGCGG
CATGTTTAAG
'ITAAAAACCT
AAAAATI'TGA
CTACAATCAA
GGCTITATTCG
CCC CAAAGAA
CATICAGGCT
AACGCCAGAG
GCATAAAA
AGGATIAGAG
TGATGGGGAT
AGAAAAACAC
TAGGATTIGCG
CGCTAAACGC
TCAAGTGATG
TAGCAATTIA
GCATATCTIT
GGCTI'TGGAG
CCCCTATTCC
AATCATTCGC
AGAAATCATC
CGCAAGCAAC
TACAACGGCT
TI'AAAAA.ACA
AAAGTCAATG
AATCI'AAAT
CCGA'TITTAA
TTCCTAACC
ATGCGAGAAA
ATGCTAAGCT
TTGCATGCTC
TATAACGCAA
AAAATCAAGC
TTTlAAAGAAC
TTATI'GCTI'G
TACACCACOC
AACTTACAAG
AGCATI'GATG
ACCCACCCCC
TTIAAAATCAC
CGCTrTTTAAA
CCCTAGAAGC
ACAAAATCGC
AGGCTTTAAA
ACCACCCAGA
ACGCTATTIT
CTCATCATAT
AAGGCATCAC
TCAATACTII'
TCAAAGAAAC
GCTATI'r1GG
AACAAAGTCC
CTGAAGAAAA
AAGCGCTI'AA
GCGTGAGAGT
TATTTAGTCA
GCTCAATCAA
CGCAAAGCAT
GTATCATCGC
CCTGGATT
CATTrGATT
CCCTAGCGAA
AATAGGCTT
CTATGCGGGC
CCCTI'TGTG
TGGTAAGACG,
TAATGCGCAT
CTATGATGAC
AAGCGACTT'G
AATCGCCGTG
AAACCCGCCA
GGTTIGA.A
GCCGCTT
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1017 INFORMATION FOR SEQ ID NO:150: SEQUENCE CHARACTERISTICS: LENGTH: 621 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular PO/US 9 6 /09122 JPENS 18 DEC 1996 (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1 621 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:150
ATGTCCAAGA
ATAAGGGAGA
AGCATGGCGT
AGTAGCATGG
GTGCAAATCA
TTCAACTCCG
TCA'ITTGGCG
CTTI'CTAAGC
GGTTATGTGC
GTCGCTATGG
ACCTrCAAAA
TGAAG
TAGTGGTGAT
TITI'TAITI'C
CGGTGTATGT
CTGCAGAAGT
TGGCGCTGTT
AAGTCAA ITC
TITTTCACCA.A
TTGGAGGCAT
GAAGAATCCA
TGAAACCAT'
CACAACCACA
TGCTIITI=C
GGGTGCGGTC
AGTTGAACGC
GCTCACC'FrG CAACGCTA T
TACCTCATT
CGCTACAGGG
AAGAAGAGT
GCY'TrTATT
AATATCCTCT
TTITACTGG
ATI'GTGATGT
AAGCAAAGCC
ATTTTAAGCG
GATGCGCAAA
CCC TTTGAAG
ATICAAAAAA
TYCCACAAGC
TCTTTGCGAT
ATGCCAT'AC
ACGCTGAGTT
ATGCGTI'GG
CTAAAATCTI'
CTCCTAGCAT
TYCCYAACAT
CGGCGGC'FTr
TCCATGGGAA
CCAGAAAGCC
CC?'ACTITA
CGCTCTCGCT
'I"rGGGCGTG
CATGATGTTT
GTGCGTI'CTT
TGSSGAAAAC
TAAAGCGAT
AATGCTTTTA
AAATCACACG
CAATTTATAA AGGAATCTCT A INFORMATION FOR SEQ ID NO:151: Ci) SEQUENCE CHARACTERISTICS: LENGTH: 753 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .753 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:151
ATGGGTGCAA
GCGCTATT~
TCAAA.AAATA
ATI'AITTCTA
ATA'ITCTI'AT
GCTTCAAGAC
GCGCTCAATA
TTTTCAAGCG
GAACAAAGCA
GTTI'TGTTC
TTTTACTACC
TTAGCAACTT
TrI 'ATCTAT
GGACTITI'AT
CCACTGAAAT
GCGCGATCTT
TCTACATGCT
TAATCGTI'GT
TCATCACTAT
CATTGTTTTG
TCTTAGGATr
CTTAGAATA
TAATCAACT
CAACATFFT
TAACACCAAA
TrTAAAACTT
T
rrATCCTAI'
TTACITTT
TGGTCTCACA
ATCACCAGCA
AATCCTATAT
TC ITAATI'T
TTTTTGCTTG
TTGTAATATC
CCTACCTAAT
TCTAATCAA.A
CATTATTGGT
AGAACGCATG
GAAATCAAAT
TI'AATGCTCC
AATAACATTA
CAAGCTATAA
ACTI'TCAAAC
GCTTTT'ATCT
AAAGCGCTTA
GCAATTTrG
ATCAATCTCT
ATTGGTCAAT
GCTTTTCAAG
GGCATTATIT
CGT
CTIATCTCAC
TATI'ACTAAT
TAGGTCTAAT
CAAGCTCTAG
AAATAACTCT
TI'ATTG'rrCT TlFrTGGGGTT
TAGCTAGAAT
ATGCGCTAAT
TATT1TATCAA
GGATTGATAC
TATI'TTTACT
CAATACAAGC
T1TrGTTr1T
GGGACT'CT'
ATCGCATAAT
AGCATI'AATC
CTCTTTAT
TATTAGCArrr
TTICAAAAC
GTCT1'GTAAT
AACATCTATI'
TATACTGGTT
AAGCGCTAAT
120 180 240 300 360 420 480 540 600 660 720 753 POT/US 96/091 2.
1PEA/US 18DEC 1996 199 INFORMATION FOR SEQ ID NO:152: SEQUENCE CHARACTERISTICS: LENGTH: 207 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...207 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:152 ATGGCAGGCA CACAAGCTAT ATATGAATCA TCTTCTGCAG GATTCTTATC GCAAGTCTCC TCAATCATCT CAAGCACAAG TGGTGTCGCA GGGCCATTTG CAGGAATAGT AGCGGGCGCT 120 ATGACAGCAG CGATTATTCC TATTGTTGTG GGATTTACTA ATCCGCAAAT GACCGYTATY 180 ATTRACCCAA TAYAATCAAA GCATCGC 207 INFORMATION FOR SEQ ID NO:153: SEQUENCE CHARACTERISTICS: LENGTH: 336 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...336 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:153 GTGAGCCGTA TTTTAGGCTT GAGCGATGAT TTAGCGATGA CTTTATGCGC TGAATCCATC CGCATTCAAG CCCCTATCAA AGGTAAAGAT GTCGTTGGTA TTGAAATCCC TAACAGCCAA 120 AGCCAAATTA TTTATTTAAG AGAAATTTTA GAAAGCGAAT TGTTTCAAAA ATCCAGCTCG 180 CCTCTAACCC TAGCTTTAGG CAAAGACATT GTGGGTAACC CTTTCATCAC GGATTTAAAA 240 AAGCTCCCCC ACTTGCTCAT CGCCGGCACG ACAGGGAGCG GTAAGAGCGT GGGCGTGAAT 300 GCGATGATTT TATCCTTACT TTATAAAAAA CCCCCC 336 INFORMATION FOR SEQ ID NO:154: SEQUENCE CHARACTERISTICS: w-mmn'"W SHU L PCIUS 9 6/O1 IPENUS 18su. O I96 200 LENGTH: 456 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genornic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .456 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:154
ATGGATGAAA
GGCACTAACG
AITGACGC T
AGGCCAAGCG
TTIGCGCTC
CAGTATrCA
ATGCAACAAT
GAGATTI'TAG
GSCTCGTI'A
TGAGCATCAT
CCAXACTCGG
ATATGGAPI'
TGGT'rrCTT
CTATAGAAGA
A ITCAAGCGA
AAACTI'TAAA
TGGGGTGAT'
CTTTITCAA
CGAAGAATAC
GA'ITFAGAA
TGATGAAATT
CACGAGCGAG
ACTAGCGAGC
AGGGGTTAGG
TGCATGCCCA
AAAACGCCAA
ACCGAAAACA
ACTTTCCAAA
ACAGAAAAAA
ACAATCAGCC
CTTII TIGATG
TTGAG
GTCAGGTTTT
GCGCAAAGGA
AAAACAAAAA
ATAAAGC CCC
ATTATTCTCT
AAGCGGAGT'
AAAGCCAAAA
TGCCAACACC
AGTGATCTTG
AACGCGCTTA
AAAATCGGAT
AAACCCCGGG
TGAAAACTIG
TTTGCAACAA
120 180 240 300 360 420 456 INFORMATION FOR SEQ ID NO:155: SEQUENCE CHARACTERISTICS: LENGTH: 339 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi),ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc-feature LOCATION .339 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:155
ATGAGAAGAA
GAGCATGGGG
ACGGATTGGA
AACCGATTTIA
ATTACGACTT
TI'GAAAGAAA
TI'ATTAAAAA
TGGAAGCTTG
ACATGCCTGA
AGGAAATCCC
TAAAAGCGGG
AAITAGAGGT
CACACTTTCA
GGAAAAACTA
AATGAACGGG
TATCATrATG
CGTGAATAAC
TGTTAGGG
CGC'ITAGGCT
GACGCTAATG
TI'GGATCTCG
ATCACCACAG
TACATI'GTGA
ACAAACGAT
ATGAAGATGT
CGGACACTAA
'rrAAAAAGGT
AGGGCGGTAA
AACCTITTTAC
'TTAGAAGCT
GGTGCT'A'r
GCGTGCGGAT
AGCTGAGGTC
CCCCCAAGT'
INFORMATION FOR SEQ ID NO:156: SEQUENCE CHARACTERISTICS: LENGTH: 549 base pairs erm", PCT/US 96 09122 IPEN1 S 0 E C 1996 201 (B3) TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii):HYPOTHETICAL: No (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .549 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:156
ATGGCAGAAG
rr'rGTCATTA C ITATGGGGA
GCTAATCCTA
TrGGTGCTTG
AATGGCAGAC
AATGAAGTCA
AAAAGCGTGG
AGCCATTI'GA
ATTATCCAA
A).CAAGAAAA
'ITGGAAGCGT
ATAAGGAAGA
TGGCGAACAA
GGCCTTTGTA
GCTACCTTAA
AGGTrAAAGA
AAGAAGTGGT
ATTCGTI'T
TACCGCGCAA
GCTAGTGATG
ATCTAAAGAA
GAATCAAGAA
TGCGATTGAT
GGCTI'CTAI'
CACGGCGATI'
TACTAACAAA
GATTGATIGGC
CAACCCCAAA
CTTITATI'GG
AACGCTTCTA
GCCAAAGAAG
GCGCCTTTTG
TCGCTAGAAT
AAGGACACGA
GGCAAAAACA
T1'TATTAAAA
AAAAAAGCAA
TGGGGGTGAT
AAAACACCCA
GCTCTAATAT
CGGTGAA?1'T
TGAGCAATGA
TTATAGAAAT
AGCTTAAAGA
ATGTCT717TI1
AGCCCTTITA
TATCAT1GCTG
AGAAGTCCAA
CCAGCAATAT
GGTCTCTCAA
AAAGCTITG
TCTATCGTCT
TGAAATTAAG
CACTGATTTC
120 180 240 300 360 420 480 540 549 INFORMATION FOR SEQ ID NO:1S7: SEQUENCE CHARACTERISTICS: LENGTH: 105 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .105 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:157 ATGGGGTGTT TTAGCACCAT TrGTTGTAAG GGTTrAACGC TTAGCGTT1GG TGGATTI GTGATOATGA GATTCI'AAT ATTCAAAGAT TTIGCAAAG AT'1'I INFORMATION FOR SEQ ID NO:158: SEQUENCE CHARACTERISTICS: LENGTH: 2106 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular PO/U 96/O9i2 WEPNUS 18 DEC 1996 202 (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv)Y ANTI-SENSE:
NO
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .2106 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1S8
GTGGCGCGTC
TCTCAATACT
TATTTI'TAG
TCTITCATGC
TTGCAAGAAA
AACTCTAAAG
AAACCCCTAG
AAAGAT'ATI'
AAAGCI'ATG
ACGCCTTTGG
TTAAAAGAGA
CAAGAATTAG
AAAGCCCCCA
AAAGAAAACT
?1'CCCTGAAC
TGTTTGATGG
CCTTTIGAGCG
GAAGTGAGCC
GGGGCAACCG
TACCAAAACA
TTTTTAAAG
ccTAATTTGC
CCTTCAAGGG
CTTTATGAGA
AGAACCTCAT
AACGCT'TTGA
ATCACCCAAA
GAAGAGTCTA
GTGGAAAACG
AATGGCGTGG
CATAGI'LTI
r GAAACACA
CCTCTGTATG
GATGTGAGTI
GTCAATAAAC
AAGAGT
TTGTGGTTAA
TGCAAGCGAS
'ITTTAGAAAG
ACGCTAATAG
cTTTAAAAAG AGGTITrTGAA.
TAGGGGGGTA
TCATICAAGA
AGAGCGAAAG
ATATTATCTI!
GGGccAAGTT
TCAAAACCAA
G 1 TGGAGGA
TAGTGGGCGT
GCATCCAT
TGTTTGAAAG
TGTI-rAAAAA
ATAATAACGC
GAAGCGGTAA
TGCGCCTITI'
GGcATTACCA
AGAATI'TAGA
ATAAAGAAGC
CCTTATACCC
CTAACCAAT'I
ATGACGCGTI
ACCCTAAAGA
*GGAAAAACGP
ATTTGTTAAI
TGGTGTrGGC
TAAGCAACAJ
ATI'rCAAG
ICCAGGCAGGI
TGGAGGGCTr TGAAAGCG7
AAGGCGTAAA
CTTGAATCAG
CACTCACTCT
AGAAATIT
CTI!AGAAATC
TTTATGCA
ITrGAGCGAT AAGCTrAAT
GATCACTICT
TTCCATAGAG
TAGCATGTCT
ACGATITATCC
TTTAGACGCT
TATAGAAACT
AAACCACCGC
GCAAAATTTA
TTTGGATTAT
TAAAGAAATT
AAGCACGCTG
AGCTTTTGAC
TGACGGCCAA
,AT'TTTTGCAA
CTrAGAAGAC
CAAAGATTTT
GGGCTTGAGT
CAACTCCAAC
CTTAGGGCTI
CAGCGGCTI
CACTAAAATC
CTTGCAAGAC
6GGGGACTCTC SGCCTI GAGC r' TTAGTCAAI V' GGGGTGTTA', r ACAAAAAGA(
ATTGATTATA
TTTGAAAATA
TTGCATGGCG
AAGGATATTC
CAGCTCAAAA
GAATATAT1TA
AGCTATATCG
CAAAAAACCT
ATAGCGGTGG
CCTATGAGCG
AATC2-TGTTA
ATGCAAAAAT
CAAACCAGCT
TTTGGCTTGA
I'IGCGTTT
GGTrAAGG TCCCCI-I Tr
GCCAGAGTGA
ATrAGCTATI
AGGATGCAAG
TCTI'rrAGTA
TCCTITTI
ATGAATGCGP
AGTI'TGCTGC-
TI'AGAGCCGI
*GCTTITTT'AI
TTrAGCCTATI TTGGTrI
*AACGCTTTAJ
ATTrACCAA( ATITrGTATx
GAAACTGAN.
k AATCTGGGTZ rTTGAAAATC'
"TACCCTACAI
AACAXAGCAT
PLAGAAGTGTA
TTTTGGAGCA
TCTC7I'ATAA
ACTATGCCCC
ATGGGTITGA
CTAGTTCTAT
ATAACCGCTT
GAGCGCTITTT
TCAATAAAAC
AAAACGAGCT
TCGCCCTAAA
TAATI 'rAGG
AAGGGGGGTA
TAACCTCTAA
CTAATTCATG
TATTCAATTT
ATG7GGCATAC
TAATGATGAG
GGTTGTATI'C
*TCAACCCCTT
*TGAGCATTT
17rCTGGCGC
ATI'ITAAAGA
ATTTGAATAA.
ATGTGATAA
7ACTTGTI'I'IA
TAGACGAAT
k. TCACGCAAGC
:TTAGCGGQG!I
:CGCAAAAAAP
k TTTCT?1TrrI k. ACGGGAGTTC r TTAATTCACJ 'a AGTGGCGTG;
TCAATCTGAC
TGAGAATCAG
TAAGAAAAAA
AGCGCATITIT
CAAACTCTTA
ACTCCCTTTA
CACTTTTGAA
GATTGGCATr
ATACCAAGAG,
GCTGAGTTT
ATTAGAATAC
CGTTCT
5
ATC
GCTITrIATTT TTrTTCCTrI'
AGCCCTAGCG
GGGGAATAGC
CCACAACCAA
TTTAGTTATA
CGCTI'TAAAA
7I1'ACCGAA TI'GTrrAGAG
GGATCTTGCC
GATrAAGAGC
AACGCTTAAA
CCCCC'TTT
CCTAGATGCG
TAAGATC
T
rrA
T.AAATCCTAT
CAGGAAAGCT
TAAAAACGCC
CGCTAGGGAA
AGAAAACACC
CAACATG3ATT TrCCAGTCAT
LGAAACTT'
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1140 1200 1260 1320 1380 1440 1500 1560 1620 1680 1740 1800 1860 1920 1980 2040 2100 2106 INFORMATION FOR SEQ ID NO:1S9: SEQUENCE CHARACTERISTICS: LENGTH: 879 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genornic) (iii) HYPOTHETICAL: NO POT/US 9'o/091z2.
1PENLI;S 18 DEC 1996 203 (iv) ANT~I-SENSE: NO (v)ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ixf FEATURE: NAME/KEY: misc_feature LOCATION .879 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:159
ATGCAAGAAG
GGGAA~wrTTG GACGCGcTAA AT'TrCAAAA
TCGGGTAGGG
ACTI'CGTCTA
CAAAATITAG
ATAGAAAATA
CAAGGGAAAG
CTATTAGCCC
GCGGTGGTGG
ATTGAAGCCA
AACCAGGTTA
GAGGGCAATC
TCTAACGATA
ACTGGCAAGC
CGGTGCGCAT
ATGGGATCAT
TCTITGAAAG
TGcAATrGGT
ATTTGCCAA
AAAAGGCT'C
TCACCACTC
ACATI'AAAAG
TAAACGCTGC
CTGATGAGGT
ATAT1'AATAT
AAGAAGTAGA
TAAAAATCGC
TITTTAGAAGA
CGTCCAAGAC ACCATITAAAG
CACGGCTGAA
GsAYTATITG
CTATI'CTGGC
TACTAACGCT
AGATCTAGCG
AAACTCCCAA
CATTCAAGGC
CATIGTAGAA
TATTGAAGCC
GAGGAAGCTC
TCTCGTTCAA
AGAGATCAAC
TAGCGATT1CT
TGTGAATAAA
CCCGCAAGCC
CAAGAAAGCG
TTGGATITTTA
T1'AGGGCAAG
AACGATAGCO
CACAAAAGCC
GTGAGCTCTC
ATCATIAGAG,
GCACGAGCCG
GCTGAAAGGA
AGCAI'TCAG
GCTTCTATTG
TITAGAAATCA
AAGCAGTT
TGGTI'TCAGA.
CTGA?11'GAA
TAGGGACTCA
GAGGGCGGAT
AAATCCAAAA
CGAAT1'TAAA
TGATGGAAAC
AAAGTGAAGC
ATAT1TGCCGA
GCGAGCATGG
CGCAAAAATC
ACACGAGCGA
AAGCCTTAAG
GTCAAGAAAT
TGTIGAAAGCG
AGAATTGAGA
CATGCCAAGC
CCAAAACGCT
AATGCTAGAA
AGAATGCGTG
TCCAAAACG
CATGATI'GAA
TCAAACGAAT
CAGAGGCTI'
CCTCAGTGAG
AAGCATTAAA
ATCGGTTACT
TGACAAAGTC
120 180 240 300 360 420 480 540 600 660 720 780 840 879 INFORMATION FOR SEQ ID NO:160: SEQUENCE CHARACTERISTICS: LENGTH: 156 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .156 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:160 ATGCCTAAAA GrITTCACCT' ACCGACTTTC GTGTGGTGT' TGTTTGTGGG GGTTATCTTA AGGAACGCTI' TGTCG'TTr TAAAATCCAT AGCGTGT1'TG ACAGAGAGGT TTCAGTTATA GGGAATGTGA GCTTGAGCCT GTTTTTAGCT TACGCT INFORMATION FOR SEQ ID NO:161: SEQUENCE CHARACTERISTICS: LENGTH: 546 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular t _,r PCT/IJS 9 6/ 091ha 1 -ENA/US 18DG9 204 (ii) MOLECULE TYPE: DNA (geriomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .546 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:16l GTGGGGC'TIT TAAATTCTAA CAAGACCCCT ACGCATcAT'
TI'GCGCTI'TG
T1'AGAAGAAG
GGGGAGCGCC
TTAGATGAGC
TTGAAT'rrAC
ATCAAAGCTT
GCTATTGAAG
AGGCTI'
CTTACCCTAA
TGTGTrrAAA
AAAGAGTGGC
CAACCTCTGC
AAGAAAAGCA
TITGCGATAG
AGGTGTI'GA
GGCGTTCAAA
AAACCCTCGC
AGCTTCACAA
CCCTGAATI'G
GATCGCTAGA
TTTAGACAAA
GGATTTGAGC
GGTG'ITAGTG
CAACCCCAAA
CCCTACCGCA
TrAAGCATTC
CAAGAATGGC
CTTAACTI'
GCGATI'GCCT
AGCATrCAAA
TATTTIGTTTIA
GTGAGTGAGG
CACGCTI'ATA
AGATTTTGCA
AAAGCATIT
ACCATI 'AGC
ACGCTI'ATGA
TAAAACCTAG
AAAGCGTGTr
TCAGCCATGA
GGAAAATCGT
AATGGTGTT
AATAGAAGCT
TGAACTrTG1C
GCTCAGCGGA
AATCATI1'CTr
GGAATTATTG
TI'rAGATGTIG
GGAAACAGGC
120 180 240 300 360 420 480 540 546 CCAAGCGTIT GTrGGAATCC INFORMATION FOR SEQ ID NO:162: Ci) SEQUENCE CHARACTERISTICS: LENGTH: 753 base pairs TYPE: nucleic acid STRANDEDMESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc_feature LOCATION .753 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:162 GTGAGTT1TGA TTAAAGTrrAG TGGTGATAAA TCCATrI'CAG GCAAAGCGCG TGTGAAAATC ACAGCGACTA GAAAAATCCC TTTTAGTTTA GATGTCCCCA TTAAAGATAA AGAAAAATTT CATTTTAG GGGCTAATAA TAAAGTAAAA TACGCTAAGC GATrGGGTTT AATCAG'rrrA GAAAAACAAA AACAATITAT AGAAGATAAT CATCAAT1'TG GTGGCATGGA 'TITTGAACTC TCTrTI'GATG ATAATGAGTT GAGCGAAATA ACCCAAGCCA TGCTGTXTI' TTGCTTTI'CT TT1AAACAGAA CCGCTATGCC CAAAGAACAT CTTGTGlTTTT TAGAAATGCT TAAAATTr GTGTTWJAAGA T7IWGAAAA AATACTITCAA
AAAGTGAT'G
AGACATGCCT
AAGCATTATG
GAACTCACTA
ACTCTATG
GAAAATTTAG
TTTATGATTA
TCACGCAT'r GTTA?1TAAGG
AITT'IGGAGT
GCCCTTTTGA
GGAC'TTTAA
AAT
AGGTTTICTAT
TTAGCGATTVA
TAGAGTGGCA
cTTrAAAAGA AAI GAGCGA
AAAATACTTT
CAAGAGAAAG
CTT'ATCCT
AAcAACAATA
TAAAAACCGC
TITATCCATGA
GCCAAGTGCA
TCC'rrTAACT
TGGTATTTCA
GATCGGTTAT
TGAAAAATAT
AATGATTTAT
AAAATT1TrTA
ATTI!AGATCG
GCTCATTCAT
TGGCTCTAAA
TACCCCCI'A
AACCAACGCT
ccATAACGAT 120 180 240 300 360 420 480 540 600 660 720 753 PoT/us 9 6/G091 205 PENUS 18 DEC 996 INFORMATZION FOR SEQ ID NO:l63: SEQUENCE CHARACTERISTICS: LENGTH: 120 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular Iii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .120 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:163 GTGATCACGG CGTGTITAA TAGYGAAAAA ACCAI'GAAG ACACCATFICT TTCCGTGCTT AATCAAACT1' ATAAAAACAT TGAATACATC AT1'ATAGATG GGGCTAGCGC GATAGCACI' 120 INFORMATION FOR SEQ ID NO:164: SEQUENCE CHARACTERISTICS: LENGTH: 366 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori
FEATURE:
NAME/KEY: misc-feature LOCATION .366 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:164 GTGTTT1GTAG GGCTTTATCA TGGGGCAAGC ATCTTrGATr TAAAArI'DGA AGTCTATC~r ACTATGCTAA TCTCTTTAAT GCCCTTTGTG GCTACGAT ATATCAAT'T CCCAAAAACC 120 ACAGAAACTr CGCATGGCTA TGCGAGATGG GCTAATGTrA. AAGATATAGA ATGC'1TTAAA 180 ATTTAGCA AAGAGGGCTT TTGTAAAGTG GTGCATAGAT TAGGGGTGCA AT TGATAAT 240 GGCTI'ATI'C TAGGTAAATT TGGTI'CA AAGCTTAGAA ATGTGTGCTA TGACAAGCCC 300 TTAGGAACGA TGATTGTT GC ACCCCCTGGT GCGGAAAAAC TGCATGTGTG GCT'ITGCCAA. 360 ATTT1AT 366 INFORMATION FOR SEQ ID NO:165: SEQUENCE CHARACTERISTICS: LENGTH: 339 base pairs TYPE: nucleic acid STRANDEDNESS: double POUS 9 6/ 091h S; 18i~ sDECl1996 206 TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .339 (xi) SEQUENCE DESCRIPTION: SEQ ID
ATGAAACGCC
CCTAAGTGGG
GAAAAAATT
TCCTCAGCCA
GAGATTAAGG
CTAAGAATCA
TTIGCTGTI'GC
CAAAAGATT G
TAGTGTGTGG
GACAAAACGC
CTGGTGAGCT
CTAAGAAGCA
GCTTATITG
CTCAAAAGAG
GATGAGCGAT
CTI'AGAGAAA
AAAGGCCACT
TGTCGCTTTA
GT13TTGGGAG AT13CGGATT'G
ATATTGCT
GTGATIGGAAG
TTTATTGATA
ATGAATGAG
TGGTGT'GGG
AAAAGACCCA
CAGATAT(;GA
CTTI'CAAGGG
CGGATAAAGT
GAAATCC?1'G
AACCAAAGAT
TrATAGCTIG
GGATAGAATA
TTATGTGCTT
120 180 240 300 339 INFORMATION FOR SEQ ID NO:166: SEQUENCE CHARACTERISTICS: LENGTH: 1313. base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1311 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:166
ATGAACCCCC
TCAGGCAAT1'
GCTAAGGAAT
?1'TATGCTAG
AAAAAGGGGC
ATGCTCGCAT
?I!AGCCAGGC
CTCTCTGAAT
TI'AGTGGGAG
CATGAGCAAA
CTACTCTCGC
CAAAAAAAGA
AGTrTAAAGG
GGAGGGAGI'
TCATCGTITrA
TTCTTACAAC
G~TT'rGCGA
AGATI'CAACC
TAGTGGAATG
TI'ACCCACAC
GGTITI'I'CAT
GTAAAACTI'C
TGCTCCCCAC
TTTACAGGG
TAGGCAAGAA
GGCAACTCITI
TCAGCGCGTI'
TC TTTGAG
CTAATGTAAA
AATrGCTCAA
TGTGCTTITTA
GCCCTAAAGA
CCTrATGCGG
TCACAGGGCT
CGCCACTAAA
GTATGATT
CAATGACCCT
GCGCCCTI'TG
CATGGTGTAT
TAAAGAAATC
CTTTAGCGTG
TGGTAAAAAA
AGCTATTTT
TGCT'rGGCGT
AAATATCATG
TAATACAAAA
CCATAAAAAA
CACTTTTACG
AAGCAGTTr
GATGCTI'GCG
TATTGTAACG
AAACCCTI'AA
TACGCTTATG
ACTCTAGCGC
GGGAGTTTGT
TCCATTATCC
GTAGGGGAAT
GGAGGAGAAT
GGTI'ITrATG
TCGCTCITTA
TATTTATTCG
GAAGAAACTA
GAAACCCATA
GCCTTAATGA
GTGTAT'TTAA
ATCATGCTT
GATAAAATCA
CCTATTGTCT
AATCCCT1TT
CGTTCCTTGC
TCATCTCAGC
TTTTGTAA
TI'AT<GCGCT
GGCGTTCT'r
ATGGGTGGT
GCTCTTI'CCA
TCGTTGAAAA
CTTTAGAGGG
TGGATAATGA
TCAAAGAAAC
TAGTCT1'IGG
AAATCTTTT
TAGCGCTCTC
AACGCACCCA
TTTATGGTAT
AGCCGCTAGT
TCCTTATTTC
ATTQGGGAT
AGGCTCTI'TC
GTT1'TTATITG
CGCCACTI'AT
ATATGTAACT
CGTTTACACG
TATATI'AGCC
AGCGACTCCT
CCAAAGAGGC
GCTAACTATG
AACCAACAGC
rrrATICATC
AATGCTGATG
CAAGCATGCC
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 Puit~6 96091k2 Wrhid SDEC1996
ACTAGCGTGT_-ATGAAGCCCT
AC FI'CATIG CTGGGGTrAT GTGGGT1'TAG CCTATGCGAT TTAGAGTI'CA AACAGCATGG GTI'ATCTTTA TGGTTATGGT
ATITTTATGAA
TAAGGCGGAA
CGCCAATGCG
T'rTGAAGAG
TATCATATI'C
ATACTCGCAT
TTATTCCCTG
CTITTGGAG
GGGTGTOG
CCTAAAAAAA
TGAGCAGCAT
AACATGTGCG
GGAGCGCGAG
GCTATGTCAT
CCTATTTGGA
GAGTr=AC
AGCGCTTGGC
TTATATAGCG
GTTGAGTXFI'
G
1080 1140 1200 1260 1311 INFORMATION FOR SEQ ID NO:167: SEQUENCE CHARACTERISTICS: LENGTH: 285 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1 .285 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:167
ATGGACATTA
GAAAATACGG
AGCGTGTITTG
GCGGGGCTGC
GCGTATTTTG
GCATITTAG
CTTITAGTAT
TAGGGCATGA
AATCAAGCGG
CGG CCTrIAA
AGAATACGAT
CGGCGT GGAG
CGCAAGGGTG
CTTGAAAGTG
TGAAATAGAC
ATTAGAGGCA
TTGGGAAAAA
CATGGGCGT
TATGATITAG
AATATCCAAT
TTTACCCCAC
TCATGCGAGA
TTTGTrI'GA
GGCTAATCCC
GGCCC
CACrTITAGAT
ATACGATAAA
AGTTI'TGAGC
CACACCGGTA
INFORMATION FOR SEQ ID NO:168: SEQUENCE CHARACTERISTICS: LENGTH: 306 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION I1.. .306 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:168 GTGTGCGACA TrI'T711r1CTGA GCCCCCTATA GTI'CACCGG TTAGCGCAAR ATATCCTI'CA GAAT'ITAGCA AAAAAGCCTT GTTCARCTCA TCCTTTIGTGA TGGCGTrITrA
TGAAGATGTG
AGCI'GCTTG
TTAAAC CAT
AGRTGAAAGC
TTGGACAAAG
TGCGAAATCC
AATTTAGGGG
AAAATGGATT
GTTT1'AAACG
CGTTAGTGAT
AATGCCATIGG
CTAGGCTCGC
TGAGCGAGAT
CTCTAGCCAG
TTAT1'TCAAA
AAGCCCCCTT
TAAAGCGGGG
TGAAGCGAGC
GCAGCTITCAA
POT/u 96/09122.
IPEPPJS 18 DEC 1996 208
GGGGGA
INFORMATION FOR SEQ ID NO:169: Wi- SEQUENCE CHARACTERISTICS: LENGTH: 381 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .381 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:169
ATGT?'AAAA
GATIGGAT
GACTCTAGTC
ATI'GTCAATA
AAGTITAAAA
CGCCTGGAI'
TATTACCATA
AAATGTGTTr
TCAAGCTGGA
?TTTAAGTAT
GGGGAAATrC
AAGAAAAACT
GCAAGCCTA.A
AATTTTCCAA
GAGCCTGCTA
TTATCGCGCG
CACTTCTATG
AGTCGAAGCG
CITTTGATCAT
CCAATTGTTA
ATGATAAGCG
ACTCGGGGGA
AACGATGAAC
ACTAAAAAAG
GAATTAAAAT
GAAGTTAAAA
GTGTTTGTGT
AATI'CATGGG
CGGTGGTGAT
TAGAACCCAA
ACTCGCAACA
TCATCACGGA
GGGGGCAAAG
GAAAATGACG
TAAAAACCTI'
ATTTGGCGAT
GATATTTTAC
CAAGGGCGAA
INFORMATION FOR SEQ ID NO:170: SEQUENCE CHARACTERISTICS: LENGTH: 1506 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genornic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .1506 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:170
ATGACCTTGA
TGGTTIC
CCTI'TAGAGT
GATAGTCATG
CTAAAAAAGA
GATAATAACG
VAAAGGAAGTT
AGCCATATCC
AGCTTCGTT
TCAATAAAAG
AATCGTTCAA
TCAAACAATC
ATATACTGCA
TTGCAGAA.AT
AACCAAAGAG
ATTTAATAAA
ATCAAAAATA
TATCTCTAAA
AAAAGATr
ACI'GAATIT
TTTAGAATAC
ACTGGTC~TT1G
ACAAACTWA
AAGTTTGATA
AAATACTTGC
TrrI'CAATTC
TTTGAGA.ATG
AACATGCAAT
CTAGCCAATr
ATCCTAATAA
AAGATTTAGA
AAGAAATAGA
AAAAAATAGA
ATACAAGTI'
TAAAAATAGA
ATcTGGGCAC
AATTICGAT
AATCTATTI'
TCAAGAATCA
GAGTA.AGCAT
TCTI'TTGCT
TTCTTTA.ATT
PGTI~'- T/ 09 i L W&EUS 18BDL EGI96
ACAAAAGAAT
T'AAAATTC
ATAAAACTI'G
AGCCAGCAAA
GTGGGATCAC
CATTTGAGCG
AATCATGTTA
GATGAAATAA
TATCCCCTAA
GGAGTGGGCC
ATCACGGAI'
GACAACCCCA
ATGAAAGAAA
GATGACAGAA
GAAGAAATGC
CAAATTGAAG
GAATTIGAGCA
CAAACAAAAA
AAAAAC
TTAATAAGCT
dGI'TCCGACA
AAGTTTNATGA
GCACCGGCTI'
ATTTAGTrI'
TGCCAGCCAG
CTrTGTTr
GGATTGTGGA
ATAATGCAAG
AGCATGTTT
ATGTrrATTTVI TrCCITrTCAC CCAT1'GAAAA
AATGCG'TT
ATGATCCCAT
ATrIGIT1CAG TGGCT1TrTAA
GAAATT'
TTAGCGATC
TAACAATAAG
?1'GCAGAAAA
CCAATGGGCG
TAACCATAAT
AAAGGAGTT
AGCCACCCAT
AA6AGGAAACA cAAAGACTCC
TCATAACCCC
GAGCGCTIT
TTTTACCC
ACTI'TGCGAG
TAACCAACAA
CACCATCCTA
CGCAAACGAT
AACAAGGCTT
AAAATTAT'C
GTTCAAGATA
CTTCCTAGAG
TCCCACGATC
TTTAATTrCA
ATTATCTATG
AGGAAATTT
GACCCCITFI
GAAGGCTCTG
GACGCTI'TGG
CAAAAACACC
AAATTGTAT'r
ATI'TCAGGGC
TTIAGACAATC
GCAACGAGCG
CAACTCTCAG
AGAAACAAAT
TTGTATGGCG
AAATGGATG
GTCCCCAAGA
AGAAATATAC
ACAATGAGCC
TGTrGCT'
TCATGGACGA
TAAAAGAATA
TAGTGGATAC
TAATTAAGAA
ACAAAATCAA
GAATCA'TT
TGCGTTACAA
TTAAAAACGA
ACCCTATrGT
AACGATI'AA
ACTGCGATAG
ACGCTAAAAA
GAGAAGATGC
CATGGGCTAC
TAGTTACCAA
GGAACATGAA
AATCATCTTA
TCTFITATAAT
GCCAGCCACT
CGCTCATAAA
GGATCATTTIA
TCACTTTAAC
ACGCTCEIIITA
TGTAGAAGGC
AGAATACAAG
TTCAAACGAT
TITGACAGAC
AAGAGCTAAT
GCATTTCAAA
TAAGCAAAiTG
GATAGAAAAA
AAACTTGATC
480 540 600 660 720 780 840 900 960 1020 1080 1140 1200 1260 1320 1380 1440 1500 1506 INFORMATION FOR SEQ ID NO:171: SEQUENCE CHARACTERISTICS: LENGTH: 126 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .126 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:171 GTGTATrTrr T'TCTGGCAT' GAGCGGGGAA AA.AGTCTTAC TGCCCGTCAT TGGCGGTrA GAAAAAAACG CGCTAGAAGC CGGGCTGTI!A AAGGGGGATA GAATCCTTCT ATCAACCATC
AAAAAA
INFORMATION FOR SEQ ID NO:172: SEQUENCE CHARACTERISTICS: LENGTH: 1050 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori
T.
PCTUS 96/0912.2 [PENS 180DEC1996 (ix) FEATURE: NAME/KEY: misc-feature LOCATION .1050 (xi)_-SEQUENCE DESCRIPTION: SEQ ID NO:172
ATGGAAAATT
CTITTTAGAAG
CTrTCCTCCTG
AACCTAAAAA
TTTGAACATG
GACATCAATT
AAGCCACAGC
T-r AAAGGC
AAAGAAAATG
GAAAATITTAC
CCTAATATTI'
AACACACCGC
AAATTCTTTA
GAAATAGAAA
TTAGCTCAAA
AACGCCATCA
GAGCI'TGAAA
GCGCTTI'ATA
TI'AAACTCAT CAACTI"T1 CTCTTTATAC CAACACAGGC AACATGCCGT GAATATI'AGT CCTTIITA TCAAGGAAAC CTACTATCCC TCTTACTATC
TGAATAGCGA,TGATGCTCAT
TCCAATIT= CTACAATCCA AAAACCTAGG TI!AATCCAT CGATGTTTAT TCCTATAGAA AATrTAGCAAG CAAAGAAAAA TAAATGCTAA TACAATAAGA TAGAAGAAAG TCCCAAAAGG TTATGGTGAG CATTCTI'ATA GCGGTTTGCA CCATACAAAA AATrACAGAT TCAAATr ACACGATATC CGATAATGAA AAGAAAGCGC TTCTGRCITTT GGGGTATGGA GGTI'AGAGGC
ACCGGTCAAA
CT=rGTGATC
GAATTCAGAA
ACCGCTAATC
CAATACCCCA
ATCGACAAACC
TCCCTICCC
TCTAATTTAG
TTATCTATTG
GAATTrGATTG
AAGTCTGTCT
CTTTTAAATT
GACAATCGTG
ATGCAAGAGT
GCCACCACGC
ACGGGAGTIT
ATCAGACACA
ACGATG3CGGG
CTACTGCCAA
AAATCAAACT
CCATTAGTAT
CACAAACCAG
T1'ATAAACAC
CCATGACAAT
ATAAAATCGC
TrAATTCTCT
AAATCCTACA
ATATCCAAAT
TGTI'rGGTTG
TCAAGTATCT
ITrTTAAAAGC
ACAATAAGGA
T1'AAAGACAT
GCTAI'CTAT
TAAAACCA6AT
TCAAGTCAGT
CGATGCCGAC
CCGCACTGAA
TTACAGCAAA
AACAATAACG
GAC 1TATGAA
TCAAACCTAT
TAAAGCATTG
ATGTTTCAAC
CAAAGATGAA
GGGTITTATC
ITrI'ATI'GAT
TCTGTTTAAG
ATTTTTATTA
AGCCTTGTTT
GCTAGAAAAA
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1050 INFORMATION FOR SEQ ID NO:173: SEQUENCE CHARACTERISTICS: LENGTH: 1395 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori
FEATURE:
NAME/KEY: misc-feature LOCATION .1395 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:173
ATGGATITTTA
TIGGTTTTAC
AACCCGCAAC
GTITGAAGAGT
CAAATCAATA
TTTGAAAAAC
GAGATAAAAG
ACTAAAAGAT
GAAATTGAAA
ATCCAATI'GA
GTTAAAGAAT
GGATI'GGTAA
AAACTGCCT'
GAAGI'AAAA
CAATTGCTT
AAAAATGCCC
TTATrGAAAT CGAATI'rATT
CAGACAAGGC
AAGCAAGCAT
GAGTCTATAA
AAAGTI'CTCG
ACGATCTGAT
TTCTAACCCA
CCCACCATAA
ACGACCATCT
GAGAAATAAT
TI'GAATCAAT
AACTAGAA.?r
CAGCAACAAA
TAATTT1TGAA AAAAAATGTG CCACTCTAAAi
TAGCATCTI'A
CAATAAAATA
GATrCTAGA
GGATAATAGT
TGT'TATGAA
TGATAGAAAT
CACAAACAGC
TGAAACGCAT
TAAAGATAT
CCC CAGTATI'
AAACAATGAA
TGAATTAGCT
TI'ATTATTCT
GGACTACACA,
GATAAGGGCG
CAAGAGCCAC
GATCCTAT1'G
AAPLGAAGATG
GCGA.ATAAAG
ATTGATAGAA
TTAAAAGAAT
AAGAAAGCCT
TACCAAGAAG
TCTAGCGCTG
AATACCAAAC
AAAGAAGTGC
TGGATAGATA
CGTI'TCTI'TG
TGCAAAAAAA
ATG?1'GCAAC
TCCCTITATGT
AATGGGCA.AA
TCAATTTCT'
AAGGGI'TGA
ATAGAGAATI'
TGAAAGAGCA
TAGAAAATGG
TAGAAAGAAC
AGTATTTCAA
TGAATACTAA
ATATtTTAAT
AAGATGATAA
TTTCTCAAAT
GAAACCCAAG
AAACAATCCT
CGTCAAAACG
GTATTTAAGC
TGCCAATGGT
AAGGCGCATC
'TTrATAAAM
AGGGTTIAGAA
CAATGAAATC
AAAAGATGGT
GCTTTACAAC
CGACAATGAA
CCTAGAGCAA
TGCGAATITT
120 180 240 300 360 420 480 540 600 660 720 780 840 900 PCTUS 9 6/O0912 a PEAUS 18 D EC1996 GCTIGGAAAA TGCATAGGCT AATAACGCTA ATAAGAITAA AAAGAAGAAC AAAGCGCTAT AGTTTAGA.AG AAATCGCTCA GTAATGGTG ATGGGAATAA AACAATITIC AAAAAGCTA ATCATTCAAG CTAAAGAGGG CCTATTAAAA ATACAATAGA ATAATCATCC AAAT
TATCAATGAA
GCAATITC
ACAAGAAAAC
AGCAAAAAT
AAGAGAAATC
TAAGGAGCGT
TGGTAATGAG
GACTAATACT
AATAAACTCA
TITTAATAATG
AGAGATAT'
GAATTGCAAA
AAGCCTITIA
TATGACAAAT
CGACAAAATT
TCTAACAATA
AAGAAA.ACCA
GTT1CTATIT
CTTTAAGAAG
AATACTATGA
AAGAAATITT
TGGTAAGCTT
CTAGTGCAAA
TTATI'CAAAA
TCTCAGCGCC
AGGCTGGACT
CGCTCTTTTA
AAGCGTITAT
AAGAGACACC
GAGTGCAGCA
TAACAATAAC
TAATGATAAT
960 1020 1080 1140 1200 1260 1320 1380 1395 INFORMATION FOR SEQ ID NO:174: SEQUENCE CHARACTERISTICS: LENGTH: 579 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .579 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:174
ATGGCGCT'G
AAATATGAAG
AAACAATTTG
TATTATA
CTAGAGTIG
GTGATGGCGT
TTGCATAGCG
GTTGAAGGGA
TATGACCCAA
CTAATAAAGT
AAGTGGT=I
GGTITTAAGGC
AAGTI'TATCA
ACGAGATTI'
GCGCTATCAT
TTATTGATAA
AATrGCAAGT
GTCCGCCTGA
GCCGTATGCT
GGCGTTTITG
ATGGGATIITT
GTTGTTTCAA
CTATCAAAGT
AAAAACCCCT
AGAGCAAAAG
GCATrATCAA
GTTGTGCGAG
TAAACCCAAG
AATGATAGCG
GGCTATAACA
GATGGCGTGA
AAGCATGGCA
GGGGGGATI'
ATCGCTCAAG
CTTITGATA
AATTATATT
TITTTAGGGA
ATI'ATCGCTA
ATAGCGTCAA
GCAAGGTT
ITTrTGACAG
ACGATAGTAA
CAAGGAATGA
AAGAAATAGA
GGGGGCAT
TCCATATCGC
TI!ACTAAGTA
ATATCAT1TCA
TGATTATGAA
CATGCATT'A
AGAGGGTITG
AAAGATCCAA
TGCATTAGCC
GAATAGCGAR
TTCAGCGGCC
TITTAAGAGC
A.AAATACGCC
AGCGCTAAGG
INFORMATION FOR SEQ ID NO:175: SEQUENCE CHARACTERISTICS: LENGTH: 423 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature POT/US 9 61/091Ta2a 'PEN/US 180DEC 1996 212 LOCATION .423 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:175
ATGCTCAAAA
'ITCATCCCT
ITTTGTGGGCA
'FITCCAGGAC
TArrITITTAG
TI'TGTCGCTC!
GCGCAGT1' rTwr
AAAAGATI'GA
TAGTNTT'ITC
AAAAACTGGG
TCATTGCGTA
GTCAAAATAA
TAAGCGCCTI'
TTGGGAGCAA
TTTGCATAAA.
TATGATCTCA
TAAAGAAGCT
TGAA?1'GCI'
AACCCATAGG
TA'TTTTGAGC
TGAC!GCT1'TA
GATTCTATTA
CTTTCTAC?1'
ATCGCTGCGG
'1-rGGTTTTG
GCTAGGCTTG
ATGGCGTTAT
TI'CAACATGT
GGAAGCTCTT
ACTCTATGGT
TCAATATCGC
GGGCAGCGAG
TGTTrAGCAG
TGCCTTITAG
CAAACGCTAT
TTTTTATTAC
AGATGACATG
ATGGCCTATT
CATI'GTGGGG
CGTGTIITAT
CGAAAATATC
AT1IGAAATCA INFORMATION FOR SEQ ID NO:176: SEQUENCE CHARACTERISTICS: LENGTH: 477 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .477 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:176
GTGAAATGTI!
AAAACGACTA
TI'AGTCCAGC
ATACTAGGGG
GTTGGCATGG
TTAGACTACG
AGCGTGAATG
GTRCTGGTrA
TATTAATAAA
CCCCTATTT
ATTATTTACT
GTTTGTCGGG,
AGAGCGCGAA
CTAAATTACA
AAGCCAATAT
CARCGAGCCA
AAAATCACTT
AGCGCCTATG
GGCTTTAGAG
TOCSCAAAGG
AGTCTITAARC
AAACCACCCT
CATI'CAAGCC
AACCCCTAAA
CTATTTGCAC
AGCGTGGTGG
CAT GTAAAG
GCTAAAATCG
CAAATGGGGR
TAI'ATCATT
TTAAACGGGR
GTGRTCT1'AA
TGAAACCATT
CTGGGAGGTT
GGT'I'IATGGG
TCGTAATTGG
CTAAAGTAAC
TGTATGATTT
CGGTGGGGCT
GAAGGCATIT
GCCGGACCTA
GRCTSCSCAT
TAAGGGGGTC
AGGCGGTGTG
GATTTTAGAA
AGAAGTCTTA
AGTGGGAGCG
AAAATAC
120 180 240 300 360 420 477 INFORMATION FOR SEQ ID 14:177: Wi SEQUENCE CHARACTERISTICS: LENGTH: 1128 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: N ORGANISM: Helicobacter pylori (ix) FEATURE: (2TUS 96690121 IPEANS 180JE C 1996 NAME/KEY: misc-feature LOCATION .1128 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:177
ATGCTTGCAA
GAGCAGTI'IG
GAAGACGCTC
TTGTTI'TA
GKTAGAAA
ATCCTrACTG
C'IITATAAGA
CAAGAAGATA
AAAAAAACTA
TCI'TAGATG
ATTGAAGAAT
GATrATTACT
AAAGCCACCA
AAGATCAATG
AAAGATGATG
GCACAAAAAC
AAAAAATCTA
ATGAGCGACA
GTGGTTTCTG
AAATCGTT
GT*TCAr17iTIr
TTAAAGCTCG
GAAAACAA
ACAAGTACAA
CTAAGTCAAA
AACTTCTTCC
AGGAGCGTTT
CCGCTACCAC
AAGAGCAAAA
ATTCCAATAA
TGCAGCTTGA.
ACACGCTTAT
AGAAATACTT
TGGAGTI'GAA
AAAAATTGTG
TATI'AAAAAA
AAACAACTAT
CATACCGGAA
TAGCTCAT'G
CAACGAGATA
CAAGAAGCTC
AATCAAAGAG
AAAAGAAAAA
GGCTTATGGT
TAACCCTTAT
GAGTTATTAC
TAAAGATAAG
CAAAAAAGCG
CATTTCTAAT
AAGAAACAAA
TTITAACTCG
AAGGGGCTAT
TACTI'GACT
TTGTTGGTT
GACTAATGAA
GCAAAAAGAA
CAATGTTGCC
GI7GCGTTrG
AAAAAAGAAC
TTAAACAATA
CT TGT GATT
GAGGCTCTAG
GATCTAGAGC
GCTTATGTT
TACCCCCAAG
GCTCAGGCTI'
AGCCGATTAG
TTIAGAGCA
ITGACTCCA
GAACGCTI'GG
GAAGCTI"ITr
AAAAACTTCA
TTAGACAGCT
TACAATATCT
CACTACAAGA
AAGAATAACC
GAGTITGTC
AAGAAGAAGT
CGCATGAT
ACAGAGCTAA
AGAAAGAGAC
AAGCCTI'AAA
TAAACCAAGA
TGAAAACGAG
TGCTTCAAAT
C'TrATCTTA
GAAAAGAATT
AAGCAAAAGA
CGTTTAGCAT
CTAACTTGTT
CCAATCAAAA
TCAATTGA
TCGTAGATAG
TA'TrAATTT
CCTTTGA.A
GGCTAAMT13
GGCCGCAAAA
CTTAGAAGAC
AGTTCTTA
AAGAGGTAAA
AGATAACCCT
AACATTCACG
CAGTATTTI'
GGGTGTGT
CAAGCAAGCG
GGATAATATA
TATTGCTCAA
GGCGATTGAT
GAAAAATGTC
ATTGAG'TrC
TACCCAATCC
CGATCCTATG
CTTCAAAACA
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1128 INFORMATION FOR SEQ ID NO:178: SEQUENCE CHARACTERISTICS: LENGTH: 1056 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1 .1056 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:17B
ATGGATTTCG*
TTTGTGATCC
CTCAAGCATG
TATACCACCC
CATITAGCCA
TTTAAAAACG
AAGACCAAAA
TTAAAAACCG
CTCCCTAACG
TCCATCATCG
CATAGCGGAG
TTGCATGAA
ACAGAAGAAC
GTGGATTTAG
TTGCATGTGA
GCCTCTATTG
TAGGG'ITrGA
GTAACGATAA
CITTTTTAGA
CAATI'GCTITT
CCACCCYCAA
CCAAACTCGC
TCTATTCTTG
AATACGAATA
CTCAACTI'AA
CT1'CAAAACT
GCAGTTCGCC
AATTAAGTTG
TCCI'AAAGA
CCAAATI'GTG
ACGCTTTATI'
CCAGATGGCG
AGA'TrAAAA
GTTAGGCGAT
AAAAGGCGTA
AGAATTCCCT
AAACCGCTCC
GCTI'TATCAA
CAAI'TGGAC
AAAAATCGCA
CAACGCTAAT
CGTATTGCCC
TGAGATCATT
AGTCCCT'C
CGCGAAT1I'A
TGACAACCAA
GCCTTTrCAAC
TGCAAAGACA
TTTATTTTIAG
GAAGTGTATT
T1CATTGATG
ATTGACGCTC
AGAAAATCCA
AAGAGAGTGC
TTAATCCATG
TGGAAGCI'A
GTTGATCTAT
GCI'CGCATT
CTTATTrGCG
GCTCACCTCT
AGCGTCTGTA
TCTATCGGGT
GAACAATTI
AAGAAAACTC
YGATTCCCGC
TGGGCGTGGT
AAG'rrATCAT
TTATCTTTT
TCCCTTATAT
GCCAAAACCG
CGTI'TTGTAA
AAGACAAATC
TGTGGAT'GG
TCATTGAGTI
GGCCAGGCGA
ATGATACGAG
TCGGGAACGC
TTTACCCTAA
TAGGCATCAC
TCAAAAAGT'
TTTAATCGCT
TGTGCCTAGC
AGAAGACAAC
ATITTTCTAAT
-CCTAGCCCCA
CTCTTTATGC
AGACTACOAT
CAAAGAGCGA
CGTGCATATG
GATTGCAATC
GAGAAAAGCC
CCATAGTTTIA
TTCAGGCCCT
CGAACTCACC
CCCGCCTAAT
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 ?CU 9609k2 IPENUS 18DE C 1996 GGCTCAAACG ATATGGGTriT GATTGACATIT CAAAAAGAAA GCGAAAAGAT ATCACAAAAA ATCTrCTCA TCACATGCAA GAAAGA INFORMATION FOR SEQ ID NO:179: Wi SEQUENCE CHARACTERISTICS: LENGTH: 264 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .264 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:179 TATGGGATT 1020 1056
GTGGGTGTCT
GGGGTGTTGT
T1'TAGGGAGC
GAAGTCTTCC
TTAGTCPT1'
TATCCCTCAA
TAGCATGTTT
AATACCA.ATG
CTATI'CATCA
CCCCTA'ITGG
AATAGAGGCA ATTTCTAATT TTATCTI'TTA GACGCTTATr GCTAATAAAA AACCGACTI'A AACTI'GCCAA TCAACGCAAT
GCGT
TrrATGGGTT ATGCGTTI'A ATCTCATG3CA AGAAAGGCTG AAACCGATGA AAGGCTGTIT TCTTATCGCC ATGCGTrCGT 120 180 240 264 INFORMATION FOR SEQ ID NO:180: SEQUENCE CHARACTERISTICS: LENGTH: 315 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii)- HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .315 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:180
ATGTCTI'TAG
GATCTGAGAG
AAAGGCAAAA
TGGACAATTA
CCGCCCACGA
=TTAGTGArI'
GGGCAGTGGT
CGTATCGTTS
AACGCCTTCT
GAAAT'CGCAC
ATAACCACAC
GGTAT
CAGCTCACTC
RARAGCTTAT
TTACAATTAT
GTRATCATTG
CATTCAATGG
CTTTGCCATA
TATCACGAAA
ATTAAAGCCC
GGAAAATTTIA
AAAAACRGAA
AGTAGAGGG
ATAAAGATAC
ATATTGYTTT
CTCAAAATCC
AACATI'CTAA
GGCAATATTA.
YTTGCTA
AAACTTGCTA
AACCGAACAA
TGGACAGAAT
120 180 240 300 315S POWU 9 6/ 0912 IpENJUS 1i DEC 1996 215S INFORMATION FOR SEQ ID NO:181: SEQUENCE CHARACTERISTICS: LENGTH: 228 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .228 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:181 ATGAAAAAAA CAACCCTCT TGTATTGGGC
TTAI'ATCA
GATGGGATIT CTCAAACCGA GCCTTCTTCT
TTGAATTTGG
AACCATTCTA ACGCCCAAAA ACTCTCTTTA
AAAAACGCAT
CATGAAGGCT TGCATGCGCA GAATACGCCA
TTAAGCGAGC
ATAGCTCTT' AAGCGCTGT' CTGAAGATAG CCTGCC TI'G GGAATAGGGT GTTGTCTAAT
GAGTAAAA
INFORMATION FOR SEQ ID NO:182: SEQUENCE CHARACTERISTICS: LENGTH: 294 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .294 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:l82 GTGAAAAAAG TAGAATCCAT GTGATCGTGC TCACAACGGC CAAGTGGATA AGGATAGCAC GCTATrCTA ATAAGGGTTC AAACACAAGG TrTCCACrI'T
GAATGTGGTG
GTCTTTTGTG
TGAT1TCTAAA rTrrrATTrrr
GGCTAAAGAC
CCTTTCATTG
CAAACTTCAA
GATGTGTTGG
GACGATAAAG
ACCCCTA7I'G
ACATCATGCT
AGCTTCCTAT
ACAAAAAACA
AAATCAGCT
TCTIGCAAG
rrGflwrGTrA
TAGCATI'CCT
AGTTrACGATC
TGAAAATTTA
GCGA
INFORMATION FOR SEQ ID NO:183: SEQUENCE CHARACTERISTICS: LENGTH: 486 base pairs TYPE: nucleic acid STRANDEDNESS: double a.
PCTIIJS 96I/39122 216 TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (geriomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL
SOURCE:
ORGANISM: HelicobaCter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .486 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:183
ATGGGATCT'
ACGATAGATT
GTGGTGGGGA
GAAGAAGCTG
AGTGAGGGGT
ATGCTCATIG
AAGAAACAAA
G ITTIT
AGCGCT
ACACATTCCC
TTTATGCGAA
GCATCAACGC
AATI'AGGGAC
ATITGAATTA
CAAGCAGCAT
TCGCTTTAAG
TATGGTAT
TCTCATTTITG
CGCCAATTAC
CTTAAACGAT
AGACGGGAI'
CGCGCTCTCT
GTTACTAGC
GCTGTGCGCA
TGGGGCGCTG
AAGCCAATAT
ITrrTTGATTvr
GAAATCAGGT
AAGATI'AAGC
AGCGTGTTTA
TCCAGGCGT
AGACTCTTGG
TrrTT'CTTTr ?1'ATAAACAA AGTGCCTGTA ATGGGCGTr. AGCGAA -7CG TCAAACGCAA CGCCCAAATA CTATCGCTTI'
GTATAACCCT
TTTrCATCTI' ACACCAGGTG TGGAATrGGC CCTI'tAGAC TGTTCATGGG
GGCGTTTAGC
ATGGGATCGA ACGGCATGGA 120 180 240 300 360 420 480 486 INFORMATION FOR SEQ ID NO:184: SEQUENCE CHARACTERISTICS: LENGTH: 174 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .174 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:184 GTGATrATGA CTAAGCTrGA TGGCACTrCT AAGGGCGGAG CGATT1TARG,
CGTGCTGTAT
GAGTI'GAAAT TACCCATrCT TI!ATTTAGGA ATGGGCGAAA AAGAAGACGA
TTTGATCGCT
TrGATGAAG AACGCTI'TAT AGAAGATTTG GTTGATGCGG TGTITTOTGA
ACAA
INFORMATION FOR SEQ ID NO:18S: SEQUENCE CHARACTERISTICS: LENGTH: 198 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular 120 174 (ii) MOLECULE TYPE: DNA (genomic) PGT/US 96/091 2.
IPENUS 18 DEC 1996 217 (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...198 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:185 GTGTGTGGGG CTCATGGAAA GAGCAGTATC
ACGGYCATGT
TrTGGASSGA TTATTGGGCG GCATTCTAAA
GAGTTTGATT
GATATGAGTT TGGTTTTTGA ASCCGATGAA
AGTGATTCAA
TTTTTGCGCG
ATTGTGCC
TGAGCGCGAT
TTGCCCCGCT
CCAATGTSSG AGAGAGCGCG GTTTTTTTAT TTTCCAACCC INFORMATION FOR SEQ ID NO:186: SEQUENCE CHARACTERISTICS: LENGTH: 231 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_ feature LOCATION 1...231 (xi) SEQUENCE DESCRIPTION: SEQ ID N0:186 GTGAATGAGT TAAAAAACTC TAAGCAAGTT
TTAGGGAATG
GAAAACACCA AGGTAAGGCA GACTAAAACA
RATCTGACTG
ACAGAAAAAA CAGAATTAAA TAACAAGATT
ACTGGGTTAG
GCCGCAGACA AAGAAAACCT AACTAAAGAA
AGCAGACAAA
GGAAAGCCGA
AAAAAAATCA
CCACAGAAAA
GAAAACCTAA
TCTGAGCAAC
AAGGCTAACC
AGAAAGGTTA
C
120 180 231 INFORMATION FOR SEQ ID NO:187: SEQUENCE CHARACTERISTICS: LENGTH: 555 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori POUS 96 0912a2a 4 ENUS 18 DEC 1996 (ix) FEATURE: NAME/KEY: miSC-feature LOCATION .555 (Xi) SEQUENCE DESCRIPTION: SEQ ID NO:187
ATGGATTTAC
CAAGATACCC
GGGCGTAAAA
CCTTGTGTGA
CGAAGCACT'
GAGCAAAAGC
ACAATGAACT
TTTAAGGATA
GCTAATATCT
AACAAAT'TGA
CCCTAAAACA
AAAGCTTGT'
TAAAAGAACT
TTATI'GAAGA
TITrAAAGCA TGAATGAATr
CACTAGAACA
TAGCCAATAT
TGAGCTAGAA
AGAGCCTAGC
AGATGAAGAT
TAATGAA TI! AGCGcTTAI'
ACTAGAAAGA
TrTTACGCAT
AGAAATCAGC
GGTGTTTGCT
AATAAGTTTG
ACAAAGGAAG
AAGAAAAAGA
TTGCTAGAAT
AGGCAI=AA
TTACAAAACA
AAGATAATCT
CAAGCTAGTT
AAGATAAGCA
AAGAACAAGA
TAAAAATCCC
GCTTTAACAT
TTGGCTCA?1'
AACACAGAAA
AAGAAAAGGG
ATAAAGACAC
TAGTAGAGAA
ATCAGAATGC
AGAACAAGCC
TAAAAAAAGG
TGCCTTTAGT
TAAAGAGACA
AAACACCCAA
AATAATGAAA
CCTrrAAAG
GIAATCTTA
CCCTAAAAI'I
120 180 240 300 360 420 480 540 555 CTTATTTTCA CGGCT INFORMATION FOR SEQ ID NO:188: SEQUENCE CHARACTERISTICS: LENGTH: 432 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .432 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:188 ATGGGGTGCT ATGGGATAGG GATGATCTAG RCTGTGTGTG TCTAACCTGA AAGATGAAGC CAAAAGGGCG TTGATGCGCT GATIITGAAT TGATr'GGGGA AAGGAATTTG AATGCATCAA ATTAGAAGAA AAAATTAG AGTGATT=GG TC
CATTAGCCGG
GACGAAAAAT
GCAAAAAA
G'1'IAGATGAC
ACGATI'AGCC
ACGCGCTAAT
AAATGTTAGC
TTGCTCAGCG
ACCGCTCCTT
CTCGCTrTrrG
AGAGACGCTC
TTGATTGT1'G
TTAGAAAAGC
GAGCGAATAA
TGATTI'AGA
TTGATGTGGT
AAGTGTATGA
GTTTGGGGC
GGAAGCAAAC
AhACGATCAA
GGGGAGGGAA
GCAAAAAAGC
GATCGTGGTT
AAGACTGCTC
GA.AGATGAGG
TTTAGAGAGT
AGACATAGGA
TGGAAAAAYT
120 180 240 300 360 420 432 INFORMATION FOR SEQ ID NO:189: SEQUENCE CHARACTERISTICS: LENGTH: 270 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO PrTIUS 9 6/ 91 a 1PEA/US 18 DEC 1996 219 (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc -feature LOCATION .270 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:189
ATGGAAATAC
GGAGCGTTGA
ATT1CCAGCCA CTTIAG'I GGG
GITTGGCGCA
AACAAACACA
1'1AGCGCCAT TTGTrGGGGG
GACTCAAACA
1-rCAAGCAGG CCGCAAAATC AATCGCCCTI ACCGCAAGAG AGTCATIGCCG TATCGCCACA GGCACTGCTG AGCCGAAGAA GCGAATAAAA
AAAAGGGCTT
TAGTTCTCT
CCTIWIT1CAC
TAGGAACGGT
CCCCAGATAA
CGTTAGCA
GACCGTGATC
CTCAGGGCTT
ACCCGATAAA
120 180 240 270 INFORMATION FOR SEQ ID NO:190: SEQUENCE CHARACTERISTICS: LENGTH: 804 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .804 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:190
ATGTCAGAAA
ACTAAAAAGG
GTGTTTTGGA
ATGCAAAAAA
ATGGATTCTC
GAGAGTGAAA
GAAGAAAAAC
CAAAAAGAAT
CCAAAAGATA
AAAAAAGAAG
GGCATTATT'
?rI'AATCAAT
CCTTATAAGA
AAACCGGTTIG
AAGAAAGACT
TGTrrr1'GAT
AAAGCACCAG
TAGGCAACAC
CCAAACAAGA
ATCTATGCC
AAGAATCTCA
CTCAGGCTGT
.AAGAAGCGCA
CTCGTAAAGA
TGCAAGTGGG
TCCCCCATAA
GCAAGCAAGA
TCATAGAAGT
GAATGAAGTG
CGTGGCCATA
AGTCGCTCCT
TAAAGATGAG
AGACAAGTITA
CATI'CAAACC
AAAAGAATTA
GGCTAAAAAA
TAAAGRTAAA
AG TTVICTAAG
AATI'GAAGAT
AGCCTrAATG
GCGG
ATCTAGAAG
GCCATTATCA
AAAGAGACTIT
AAAAAAGACG
GACAAAGTGG
GATCAAGCTC
AAAGCG
GAAACCCCCC
GCTAAGCATG
AAAGCTAATr
CACACGCCCA
AGGGGGGCTA
CATGCCGATG
AAGAGAATAA
TTI'TGGCGGT
TI'TACAAAC
ATGAGTTTGA
TGGATAATAT
AAATGGAGAT
AGCCTATTCC
ATAAAAAGCC
CAGCTAARGA
CTAAAACCAA
ACAAAGCCTT
CTAAACGCTA
AAGTCAGCAA
TGGGAGTGGT
GCT'TITAATG
CGATAGTGGC
AAGCTTGAAT
TAAAAAACAA
GAAAACAACA
CATGAGCACT
TAAAGTAGCG,
GCCAAAAGTC
TCTTACTAAA
TTTACAAGAG
CCTYATAGGY
GAAGATGACT
120 180 240 300 360 420 480 540 600 660 720 780 804 INFORMATION FOR SEQ ID NO:191: SEQUENCE CHARACTERISTICS: LENGTH: 513 base pairs TYPE: nucleic acid C) STRANDEDNESS: double TOPOLOGY: circular i)(ii) MOLECULE TYPE: DNA (genomic) PO/US 96 /0o9 12-2.
IPENUS 18 D EC 1996 220 (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .513 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:191
GTGGAATAT
CATI' GAATC GAGCGCTT1GG
AGGCAGATGG
GAGCCTACGA
GAGATGAAAA
AGGCACTCCA
CCAATCGCTA
TGGCATGATG
ATGCGTTI'AA
TGTTCGCTAT
ATITAGAGTC
TACTTTI'AGC
GTGCGTTAGA
AACGAGAATI'
CGCATGTGGT
TGACTICACA
ATAAGCTTGT
TTCAGCGTIG
GCCTAAAGCT
CTI'AAAAGAT
CAGAAGCTTG
I-rTAAAAAAC GAGCG 1TIA
CATGCTCAAA
CAATTI'AAGC
GGTCTATGCG
TGGATITTG
AAGCACAI'A
CAAGGCAI'A
TTGCAAAGAA
CAAGCCCTT
GTCAATATCC
GATAAAAAAC
GCGC'ITTATG
?TG
TCTTrAATGGG
AAGAAGCCAC
ACGATI'TGTC
CGCCCTTrATT
'ITTTGATGC
ATGATCCCAA
TTTTGCA
ACACGCCCCT
GAAAGCGACG
GAGCGTTI'A
CGGCGGTCAA
GI'ACTGGAT-
GATI'AAAGAT
TTITGGTVrGCC
AGCTI'CCACG
ARAAGCGATC
120 180 240 300 360 420 480 513 INFORMATION FOR SEQ ID NO:192: SEQUENCE CHARACTERI3TICS: LENGTH: 306 bas-. pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .306 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:192
ATGATGCAC
GTGGI'CAAC
AATTCAGGAT
GACAAAGCCC
TACAATATCA
GATAAA
ATTCACTI'AT
CTGATGGGAA
TGAGATG3GTA
?I'GTAACAGT
AAAACTATGG
?ITrGGTTTCA
ATTGAGCATG
TAGAGTI'AAT
GATCAATAAA
TGAATTGGAG
AAAACATCAC
ACTGATGCCG
GAAATTGCAG
GGCTATG2GGA
CGTGTGATITA
TCTCCAACCT
CCATTGATCC
AGAAGTTTAA
AAAATCCATI'
AAAAGCTCCC
GCTT'ATTI'r
TAACATGACT
GCTCATrAAA
GACAAAAAAT
TCTITGTCAGA
120 180 240 300 306 INFORMATION FOR SEQ ID NO:193: SEQUENCE CHARACTERISTICS: LENGTH: 711 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) ~E~dUS 8 EC 1996 221.
(iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc~feature LOCATION .711 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:193
GTGCTGAATG
GAAACCCCCC
ACGATTAGTA
AAGCTTI'ATA
TT-GTACTAG
ACCAATAACG
TTAGACTTGC
GATGCGATGA
CATTTITT'G
ATI'AAATTCA
TCTAAAGA.AA
GATGCGGATT
AAGAGCAAAA
TAAAGGGCAT
AAATCAAAAG
TCGCGCITGG
GGCATAAAAA
AAACGCCTAA
CTGATTTAAT
TGCAAAAAGC
ATAAGATCGC
AAGAAAAGGA
ACGCGAGCGT
TGTAI'ATCA
TTCATTAGAA
TCATTCTAAA
CTCTAAAGAG
AATA7I'GCTT
AGAAAATAAA
CGACACCAAT
CGGCAAAGAC
GAGCCTIG
ITCTrrCTCG
TTTT'AATGGG
GRGCGcGATI' 'rrATCTAAAA
GAAAAAGGGG
ATCCCCTCTT
TTTTTrCAAAC
TCACTCATCG
CAAACTTCT'
AACGCAGAAG
TCTTTGAAAA
TATGAGCAAG
CAAGGGATTG
GCGTTGGAT
GATGCGI'AG
ATTGTRAAGA
GCGAAAACAA
TGAAGCAGGC
AGCT1CTACA
CGCTCATTGT
TACAAACTAA
CCGAAGGGCA
GAAACGATGA
GGCAAAAAGA
CGAGCCATAA
TGTTTGATTC
TTACGGCTTA
GACACITTTGT
AAACGAA.AAA
T'I'GGAGCAG
CAATAAAAAA
GGCTIGAGT
TACCGCCACC
AATAGAAAAT
AAGCCAAGTG
TGAAGCCTI'G
TCTAGGGGTG
CAGTATCGCT
TcATI'TGCAA
A
120 180 240 300 360 420 480 540 600 660 711 INFORMATION FOR SEQ ID NO:194: SEQUENCE
CHARACTERISTICS:
LENGTH: 675 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .675 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:194
ATGAATACAA
CGCCTTITIGT
ATTAACGCCC
GCTCTTIACAA
CATGAGCTCA
AGCAATATCA
AATAGCGGGG
TTAACGCTCC
GCGGCGTTTT
GATI'ACACCA
cTTTITTAACG
AGAAAGCGTG
GCTIATTGAC
TAGAGCTTI'TT
CT'TACATGAA
GCGCTTI'AAT
GCCACATACG
TGCTATTGGT
CGAATTTAGC
TTTTGCAAAT
TAATGCATGA
ACAACGATTA
CTGAAATGTI'
TGATC
CCAAGCACAG
AGAAGAGGCT
CGCTr1'TGCG
AGAGAGGTTA
GCACAACGAC
GGCTAATTI'
CCGAATGATI
GTATITGAGC
CAATAAGCCC
TAAAGAAATA
TAGCACCCAC
GTITAAGCT
AAGCTTCATT
AGcGGGTGGG
GATAGAGACG
ATCCGCTTGA
AGCGTGTATT
TI'ATGGGT
CGCACACGAG
ATGATCAGAG
GATAAAAATA
CCTAGTAT1'A
CTAAAGAAAA
TTGAGCCTAA
ATGAATCTAA
AATTAAAAGC
CCATGTGCGT
-iI7-7rCATGGG
TACAGATCAT
AATACATGGC
CCT1'ACAAAA
GCACCCGATC
AAAATCGTAT
TCAAATCCAT
GCTTTATATC
TTCCCTTATC
CGTGATCGCT
GGGGATTITG
GAATCGCAAG
CTTGCCT r17
CGATAGCGGG
GATTTCTAAC
AGCGGCCTAT
CCAATCCTTA
120 180 240 300 366 420 480 540 600 660 675 n a/s 9 6!()9h2 I-PEUS 18DEC1996 222 INFORMATION VOR SEQ ID NO:195: SEQUENCE
CHARACTERISTICS:
LENGTH: 1605 base pairs TYPE: nucleic acid I(C) STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .1605 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:195
ATGTII'AATA
AATTGG'rrGA
TAI'GCATGC
GGCTATACAT
GCGCTTAGCA
ACI TAGGTC
GCTCTAACC
GATGTATCCA
GGCGGTGTTG
GCTCAAGcTT
ACTGCAAATA
GI'GTCAAAG
AI'ATCATAG
GGGATTII'G
AACATAGGI'
TC'TTTTATCG
GGTTTAGCAG
AATTACACTG
AACGCTCCTA
ATGCAAGTAP
GcTTTTAGCG
GATTCTATQI
ATTCCTATTI
TCTG~TGCTJ
TTGATCACT(
ATCGTTAACJ
GATGCCTTAJ
TTAAAAGGAC
AAGCTATTGA
TGATACCGAG
CTATI'GGTGC
cACCA 1TAGC cTTTATGGGG,
CATCAAGTGG
TGGATAGCGT
AGGACAATGT
CTACGAATAT
AACTGCAAAA
GAGCGGACGC
GGCAAGGGTC
TITTATTI'C
TTGAATACAT
CCTATGCAGG
GTGCI'TTGG
'rrAATTCAAT
GTTTGTTACA
CTATCATTAT
GTATTGTrT7
LAAAACATATI
TGCTCTrrGG LTACAAAACA1
TATITTATDT'
k CCATITCA( k TGGTGGGAAC 'TTrTTAATA.
TTrGCCCATI' TrATIGTTTTA
ATCAGGGAGT
CACAAG'TTTA
ATCGGCGTGG
CTGTAATTr
ACTAGACAAT
GAA.AGGCAAT
TACAGCTGAT
CAACACTATA
TGCTGTrCTr
ATATCTTGAT
TTTTATGAAA
GCGATGTT
TTTrrGGTT'AT
GCTGAATCAA
TTTACCTGCG
AGGCTTGCAA
GAGAATAAGC
cccTATTGCA
GATATGGTI
TGTrI'IGGCP
CAATCAAGGC
AAAAGGTTTC
CTCTGTCTC]
AGTTWGGTG
ACGATCATAA
G TTCAAATC
ACCAACAAAA
GGAAAGAGTI'
GCcGCTAGCA
GCAAGTGTTG
GGTTGGAACG
TTGAGCAACA
ATTTITTAC
GGTrrAATTr
GCCATGCI'G
CCTGCATATG
TrTGT'rrCTr
TTGAGAGATA.
GGGGGGACAT
CTTTATAAAA
GTTCTTITTIV
GTAAGAGCTG
GTGGCAGGTA
ACTGTI!GTT(
GTATGTTTG;
ATTAATAAT(
TTATTGGCA1
GGATTGGGTJ
ATAGAGACGJ
ATGGATGGTJ
kTCTATGTI'1'
TCAAAATTTA
GTTTGCAGA
CAGGGCAGGG
ATCTGGTGAA
CTACAGCTAT
CATTGATAAA
AGATTCAGAA
AAATAATI'GG
GGcTGA2-rGG CTITTGiCCGC
GTGTAGTCAA
ACCTAATWIA
TTrCAAACGG
TAI'CAAAAT
TCTCTrATI'C
GGGCTL'TAGA
TTITI'rCTAA
TTTCTTTATI
TGAAACCTI
LTCGTGCTAGP
-TGTTTATC'I'
TCAATTTGA(
k TCGATICAAC k TTATI'GAGAC k GCAGAATGGJ k AAGGA cATTIGTTCCT
CCAAACAGT
TATITTTGACA
TGTGATCGAA
ATATI'TGAAT
ACAAGGTTTTI
TAAA.AACATA
T1"rrACCAAA
CTCAATAACC
TAAAGAATI'C
ATTAGAATCT
TCTGCCTGAT
TA'rrGTTT CAT1TCAGATI'
GGCGATGGTC
TATI'rATTTT
TTAGTGCTG
TGTTGGCAAC
cGCTA
T
rTT
GATAGCGG
TrGGTCAAA
GGTTCTAGCT
CATAACGCCC
TAT1TGCGAGT
CGTCAATGCG-
k TAGAGAAAGA 120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1140 1200 1260 1320 1380 1440 1500 1560 1605 INFORMATION FOR SEQ ID NO:196: SEQUENCE
CHARACTERISTICS:
LENGTH: 426 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (geflomic) h,(iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE: NO PK.Ti68 9 6/ 0912 ,prNUS 18 DEC l996 223 (vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .426 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:196 ATGGCG'TTr
ACCATGATGT
GAAGCGAGTC
GTCCCTGAAG
AATTCTATGG
ATGT'TGGT'
GAGTTTGACC
AAAGGC
GGCAGGCTAT
GGATrCTTC
GTGCGGCTAA
AATACATGGG
ACGATAGATIT
ATTCTACGGA
ACTATGGCGA
CCGGTGGTGG
AGAAATGGCG
CCCGGTTTA
CGATGTGATI
AGGTTTGAAA
ITrGCGATCA AGTGccTAGC
ATTFI'AAAGT
TTTAAAATCG
CTAGAGCCTA
GGCGATrTAA ATcGTGAATG
GCCACTCAAG
AATATCGCTA
TACCCTTTAT
CTGGYTYTAT
TGATGAAAGT
ACAGAAGAAG
cTTTCGTGCC GGcGTGGGAC
AGGAAATCGT
GATGGGAGCT
GGCGTI'AAA
GGAAGTGGAA
AGGGCAAATC
GTTAGTGGAA
TACTCTATG
GGAAAAACGC
INFORMATION FOR SEQ ID NO:197: SEQUENCE
CHARACTERISTICS:
LENGTH: 459 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (geflomiC) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .459 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:197
ATGCAGAATT
CCTGAGGGTG
GTAGGCTATG
GCGTTAAAAA
AGA'rrGGGCT
CAAGGGATCT
TATATCCCTA
TTTGGTGGCA
TGCCGGGTAT
AAGGGGCTrr
TGAACGCCCA
ATGTGT1'GGC
TGCTTGGGTG
TACCTCCTAC
ATACAGCCAG
cTAATGGTGT
GGCGAGAGCG
TAGAGCCATG
TGGGACAAGC
TCTAAAGAAA
CTGCGGGGTI'
CATTAATCAA
AGAAAAGCAA
TGTGATTITTC
GCGATGCTAA
AAAATGGC
T
rr ACGCA 1TATA
AAGTCCCTCC
AGAAGCCGTT
GAAACGCCTG
GTGAATGCGG
A1JAAAAGCC
CCACATCATC
CAGAAATGGC
ACGATTGGTA
TGTTAGCTCC
ATTCTATCAT
ACCCAGAATG
TGATGAGTAA
AGCCCCAGCC
GAAAGTGGAA
TGAAAGCATT
ACTAAAGGGC
GGCCATGAAY
CGAYCTGGAT
CTCATTTIGGT
120 180 240 300 360 420 459 INFORMATION FOR SEQ ID NO:198: SEQUENCE
CHARACTERISTICS:
LENGTH: 279 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO PT/US 9 6*1 IPEAUS 1DEC1996 224 (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori
FEATURE:
NAME/KEY: misc_feature LOCATION .279 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:198
ATGATACTAA
GCTAATTTTT
TTAGCTTTAA
GGTTGGCTAG
TTAAGCTATG
AAAATTTGAT
ATACCATTAG
AATTTGAAGC
ACGCTAAAAG
TGAATGATTT
TTTGTTATTT
TGGGAGCAAG
ATTTCCTAAT
CAAGCTCCAA
TATATCAAAG
TTAGCAAAGA
CTTAATGAAG
TACGAATTTA
GAAGCTTACA
GTGCAAAAA
GAAAACTTAT
TCGCAAGATC
TTTGGATAAC
AATCTGTAGA
TTTCATAGAA
CTATCAAGAC
TGATGGCATA
AATCTATAAC
INFORMATION FOR SEQ ID NO:199: SEQUENCE
CHARACTERISTICS:
LENGTH: 264 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION .264 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:199 ATGGAATCAC AACTCATGAA TTACCGGTAT
TATTAGCGGG
ACCCAAATCA ATGAAATGAC CTGATTTTAA CCATGCCGTG AAGCTCATTC CTAAAATCAT ACTCGCCATT
GAAACTTATA
CTTAGTGGTG GGGCTGTTAG TTTGTC:TI7T GTGCCTAAGA GATGACGAAC
ATGCTTTTAG
AGGC
AAATCACTTT
TCAGTATTTT
TTTTAGCCGT
ATTACACCAA
GATGATTTCT
TCAAGCGACC
GATTGGGGTG
AACCTTAATC
INFORMATION FOR SEQ ID NO:200: SEQUENCE CHARACTERISTICS: LENGTH: 345 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori POT/us 96/ hPENUJS 18 D EC 1996 225 (ix) FEATURE: NAME/KEY: misc-feature LOCATION .345 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:200
ATGAAATTITI
GTGGTAACAA
AAAAGT'TGG
GTCAAAGGCA
GTITTTGCTI'
AGCACTAAGT
TrAcAAGAAT
CCAATCCTI'
TTATTCAGAT
TAGCAGATAT
ACGCGCAACC
ITGCTl'CAA
CACTGACAGC
AATGGCGGTC
CATTTCTGT
TrIGGAAAATC
CATAGCTATG
TATTGGCGAG
TACAAGAAAG
ACCAGTCCTG
CTAGCGATCG
TCT'GATGACA
TTAGCGGTGG
AGTGGAGGAG
T1'GTAGTAAC
CAACAGGCGT
TAGGTGGTIG
TCAAAAGAGG
CAGGTGGCAT
CTAGC
TI'TAGGGCTA
TACTGAGACT
cGCTTTAGGG
TCAGGCGACT
TATCTATI TG INFORMATION FOR SEQ ID NO:201: SEQUENCE
CHARACTERISTICS:
LENGTH: 573 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .573- (xi) SEQUENCE DESCRIPTION: SEQ ID NO:201
ATGAAAAATC
TACATAGATA
ACAAAAGGGG
GATGATGAAT
CCAAAAGTGC
AATATCAGTA
AGAGCCTl-rr
GAGCGTATT'
GAAATGCCAG
GCTATGATTA
CCCAAGCTAA
TGAATGATGA
CGTTAGATGA
TTGGGAGCAT
GTGAAGCTAC
TTTACATIGT
TAGAGAGTAT
TITATCATTGC
CACTTTGTCG
GAAATACTAT
TGTTTTAAAA
AAAAAACTAT
GATTATAAGG,
TATGTCTTCT
'rrCTAAAATG
AATCGCTCAA
TGCTAAAAAC
TGATGAATT
CTCTI'ATAAT
AGCGATGATG
CTCTTTTTAA
GACCCAAGAG
ACAGATGCTA
TrAAGCGTr
AGCTITGAT
ATTGATATAG
CTTATGGTCA
GTIAGATTTG
GTTGTCCCCT
A?1T
ATCAAGTGGC
AACCTGAACC
GGAGTTGGGC
TTATGTATGT
ATGAAGAATr
GCACACTTTC
AAGAAAGCTC
GTAAGTTGCC
TATTCATCAC
TGACCAAAAA
CCCTTATGGA
AAACACTCCT
CTATAAAGAC
AAGAACGGGC
TTrrTAGTA
TAAACCTGAA
GCAAGATTAT
120 180 240 300 360 420 480 540 573 IN FORMATION FOR SEQ ID NO:202: SEQUENCE CHARACTERISTICS: LENGTH: 1053 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (gerlomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL SOURCE: .1 ORGANISM: Helicobacter pylori Prui/U1W 9 6/C03 IPENUJS 18 0E C 996 (ix) FEATURE: NAME/KEY: misc~feature LOCATION 1053 (xi) 7 SEQUENCE DESCRIPTION: SEQ ID NO:202
ATGATAAGTG
TTGAATAAAA
TTAATGGCAA
ATCAAAGAAG
AGTGGTTGGA.
GTAGAAGAAG
AAAGAAGAAC
AAAT1'TATGG
CAAACCATGC
GAACGCTTTG
AGTGATGAAG
GA7II'rGAAG
GGCGAAAACG
AATA ITAAAC
AAAAAAGAAT
AAAGATTGGG
GAATGTATTA
TGGAAAAAAA
AGATTATTAA
CTI'TAAAAAC
AGCCTTTATT
ATACGCTGAC
ATTTATCTAA
AAAAACATAA
TrTGCAAAAAA C 1?ITGAAAT
TTGAGAACGC
GGGGTATAAG
GAAAGATATT
AAAGCACTA
A1'TATAAAAT cCCAATGTC
ATGTTATGGG
GAI 'ITTTGG
AGAATAAAGT
ATACTTATI'C
GTrcAATTA AAGcTTATTA
AAGCGATGAA
TAGCTGTAAT
AGAATT1'CCG
ACAAGCCCTT
AATCAAAGAA
GAAAGAACAC
T1'TGATAAT
TAGAGAGAAT
AGCC'rr
GGC
TGATACTAGA
TACTTGGTTA
AAACACAGAG
CTGTAATATG
TAAGGCAAAA
AAAGTCCTAT
TATCTCTCAT
AAAGGAATAA
GCTGGGGTTT
GACTITAITTGA
GCTAAGGTGG
CAAGAATATA
AATTTAATCA
ATTAAAGAAA
TCTAAAGAAT
GGAGCTGAAA
ACTI!ATAAAG
GAAAGAAGTI'
CAAACCTI'AT
AAACCCAAAT
TTGTTAAATA
GAAATAGATG
GTCCCAGAAA
GACAACACTA
CAC
AAATGATTAG
TACTAGGTGC
AACGAGTAAA
ACGGCTCTCA
GAGAAAAGAT
ATAAAGAAGA
AAGCTAAAGT
TCCCAAATAA
GTTITATTGA
CACTTGGCAT
ATATTAGACA
CTGCTATGGC
ATCAGCTCCA
TGATAGAGCT
GTTCTAAATA
CTTGGAGAAA
CCGCTGAAAT
ATTAAAAGGT
TACTOGCTCCC
ACTACACAAT
ATAC'I GAAT TrITTGAATGC
CACTGAAGAT
TITTAAGGCAA
AAAGCAAC?1T
TGATTGGCAC
TAAAGAATAT
ATATAAAAAA
TAATATGAGT
TAGTTCAAAT
AACCAATATC
TCCCATTCAT
TAAGATT=G
AGGAATAGTT
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1053 INFORMATION FOR SEQ ID NO:203: SEQUENCE CHARACTERISTICS:.
LENGTH: 1053 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix).FEATURE: NAME/KEY: misc..feature LOCATION .1053 (xi) SEQUEN~CE DESCRIPTION: SEQ ID NO:203
ATCGCTGATA
GTGGATATI'C
GATFI'CAAGC
GATAAAATGG
ATCCAGCTTC
CCTACGAGTT
AATCCTAGCA
GATCAAAACA
GTGATGCAAA
GCTAAAGAAT
GTGGTrr'rAG
ATTTCCATTG
AACTCCAAAA
\ATGATGGTGT
TTrTAAGCCA AGAAGAAATT
GATGCGCTT
AAAATGTCCA AAAAAAAGAT
ATTATCCCCC
GCCCTAATCG TGTGAGTAAG GAGCAATrGC CTAGGAATCT TrCCAGTcAA
GTCTCTTCTA
ATAGCGTGGA TCAAATGACT
TATGGCGAAT
TTAATGTCTT TrCCATGAAG
CCTATGGGGG
TCGCTFITCCC TATGATI'GAC AGACTATTAG GGGAGTI'AG CGATATTGAA TTGAATTTAT TTTAAAAGA AGTGTGGTCG
CCTGTGGTGG
CCAGCGCGAA TGTGGTCCAA
ATCGTCGCTC
AGAI'ATCAT TGGGCATAGC
CGTGGGATGA
AGAGCATICT TrCTAAAATG
GGGAGTAGGG
AGAGCCGTAA TAAGGAATG
CAAGCACTAT
'Tr'I'GGGCGC GGTGGAATrG AGI'TGAAAG T-WITTGAATAAAGTCGCT
AACGATGAAG
L'AGAAGTCCT
VACGCAGCGT
GCTCTTTTAG
TCATGCGTTC
TrTGATGAG
GAACGGGGGT
GGGGTAAGGG
TOGATACGAT
AGATGTATCC
AAAATGAAAT
TGAATA'TIG
ATTTCATGCT
TGAGCGGGGT
AAATGI'GGA
TGAGCGTGTA
TGATGAGAAT
AACCCTCTAT
GAGCATCCAT
TATTGTAGAA
TTTGCCTAGC
TTTAGAGATT
GAGCGCGTAT
T'rrACGCCAG
TACCATI'GAC
TTCTATCATG
TTACCCGGTG
TTCAGAAACG
GAGCGTGGAT
TTTAGATGTG
TGTACATAAG
120 180 240 300 360 420 480 540 600 660 720 780 840 900
TCAAATTAAA
WGAAGAACAG
C19 AAAAAGCGTI' K4-rAGCGAG CGTGGTT CAAGGGTATA GGAAAAC
CAT
GAAGTGG PTT ATAGCGAAAA AGAACGCACT AAAGAAA'ITT
TAGAAWTGCT
CGCAGGAGGC AAAGTTGGGC GRTGTI'ATGG
AGC
INFORMATION FOR SEQ ID NO:204: SEQUENCE
CHARACTERISTICS:
LENGTH: 570 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL
SOURCE:
ORGANISM:, Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION .570 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:204 960 1020 1053
ATGCCCACGA
GTGAATTI'AA
AGCCTTTCTA
CCTAAAGTCA
TTTGGCTTT
TTGGCAATAG
GTTITAATGG
TATAAAACC C
AAGGGTI'GGG
TTAGTCGCTC
TGT1'AGcGGT
CCGACGGGTT
TC LTIGTGTA
TAGATGTGGG
TGTGGTATAA
GAGGGTTTAT
GGTCTATI'I'T
GTAAAAAACG
CAGAAAATAA
TTGAGCT
TGGTITTTTGG
AGACGGATTA
TGTGGCAGGG
GGAATTGTTr
CTGCAACCCG
CGCT1'ATAAC
TGTAATAGAA
cCTTTTrA
GGTGATCGTG
GAAGGTGTGT
GCGAGTGTGC
AATGCGGAAT
GTGATTTCGC
GCAAGCGTGT
GCTATTGTTT
ACTCTGTCTG
ATGGCACCCA
CGTTTTTGGA
CTAGCATT1 1-TCTAAATA
TAGCATTAGT
TTATGGGCGA
CGCATAATGA
TGATCTTGCA
TCCATCATCA
TCA'TTCTAT
GAGCAATGCG
CACCCTCTTA
CTTGCTCTAT
GGGATCGCTC
TAGCGGGAGT
AATCTI'GCTC
AGTAGGGAGC
TITTGMACAA
GCTGAGTAAT
120 180 240 300 360 420 480 540 570 INFORMATION FOR SEQ ID NO:205: SEQUENCE
CHARACTERISTICS:
LENGTH: 1467 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .1467 (xi) SEQUENCE DESCRIPTION: SEQ ID \GTGCGTTTTG AAAAT'TICAT CAACCCCTA GCCT'TrACA TOOCCACAGO
GAGCGGTAAA
1\ACGATCGTCA TTATCAAACT GGTAGAGCTI TTAAGCGTGG CTATGGGAAT
GGGTTGATC
nUT/iS 9(J9 1PEAJUS-1 8SDEC 1996 228
CCTAAGAAAA
GAAATTGAAA
AAAACCGTTA
GCTCTTr
AATTIATAAGG
GGGAATAAGA
TTATTCAATT
TTGAGCGTGG
AACAACTT-AA
cal-I 1AAAGG cATGACCCTI' ATcTITTTTA
GCTAAAGACG
GATAAAGAAA
AAAGGCTTAA
cCTAAAAACA
ATIAGAATAG
AGTAAGAATI'
AATATCTTAG
ATTTATITTT
GGCAGGGGCG
,?TAGATGAAG
TGTGATACCT
ATATcATG LT
AATACAACCG
AGAATAAGGA
ATACCGCGC
ATTG ITGGGA
CTGAAAGCAA
TCAGCGCCAC
GCGAGTGGGT
ACGCTI'AA
CGTrXI'rGCT
TAATGCTCGT
AAAc'rrTAGC
ATTTATTAGA
AAGACTATAA
AAGAAGCAGT
AccAAGAAAT
GCGATATI'AC
TGAGCI'CAA
TGGGGTCTCG
TAAATATAGG
TAAGGATI'GA
CCATTAAAGA
ACCAACCATG
TTTrTAGCGCG
CAATAAGGAC
TrTTTATCGT
AGAI'TAATG
TAATGGGGAA
AAGACAGGCG
TTCACTGAA
GAAACTrGGC
GGAATTGAAA
TI'AGGCATIG
GTI'CACGCAT
GCGCGTGATT
GGAMTTAAAG
AATTGAGGTC
rTI'TATGcC
CGCTITCAAG
AGAATGGATC
AGAAGAGAC
TGCTTGAC
GCT1'GATGAT
AAGCGTCAAA
ACAAGCTGAA
CAAGCCT
AACGAGCA?1'
TATI'CCAAAC
GCTCCAAAAG
AGCGATGAAG
AATTATGTGA
A?TI'AGCC
GAAAGCGATC
TATGGTAAAG
GATTT1AAACG
CAAAAACGCT
TCTGTGAACA
GAAAATGATG
AATCCGGAAT
TTTAAAGAGA
AGTAATGGGC
CTcAACACGA
CGTGAAAAAT
TATTTICAGCC
ACTGGGTGGG
GAcGcTAAAA
AACCAACGCC
ACCAAACGCT
TAATCAAGCA
AAAT'TGATTT
AT1'CTTTAAT
AAAGCAAGGA
TTTAGATGA
TGCTGTC'rIT
TCATCACTGC
AGTCTGTTT
ACAGGGAAAA
ATAAAGTAGA
TGAAAACAG
ATGAGAGCGA
TCCrnTTTrAG
GTTTAAAGGG
ATATI'GAAGT
GCGATAAAGT
TAAAGAGCGT
AGATI'GATAA
ATAGCACAAG
AGCTGGTGAA
AAAGGTTAGC
GCAATGCTGG
ATI'GAAAAA
CAAAAACCTr
GAAAGAAATC
AAAcCTTTTA
AGCGCATAAG
AAAAGGGTITr
GGTGTATAAT
ATTGAAGAAA
AGAAATCGCT
AGGCTATT
CGATGCGRAA
TTTCAAAA
cGATGGCAAA
CATGGATTTT
CATCATTAAC
CTr'rrGCCTG
GAAGGTGGTG
GAGCAGTATC
GCCTAGCGTG
ACAATCTT
GTATTTAGAG
AAATGCTT'r 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1140 1200 1260 1320 1380 1440 1467 INFORMATION FOR SEQ ID NO:206: SEQUENCE
CHARACTERISTICS:
LENGTH: 639 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (geflomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .639 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:206
GTGTTTAAAA
GCTTGTATTT
CATI'TCACTC
TCTAT]TATT
TAGCSCGA
CCAAGTTTIAG
AATTTTTGCC
TCCTWIGCT1I
TGGTTAAACG
TATATCCTTA
CACAAATCTA
AITCCCTCT'
TGA11TrAT
CGTI'IGAAAA
TCACCGGGTT
CCTTTGGGTT
TCAATACTAT
CCATT1TTCAT
ATAACATAGC
CAAAAGCTAT
TAGTTTCT1'
ATACCCAACA
TGGTATATCA
CCT'I'I'GTC
AACCTATI'T
T1'TGGCTGAT
TTTTGGCTTT
AATTTTATAC
GAGCGATGTG
CTATGCTATA
AGCAGTGCCT
AATTGCI'1
CGAAGTGTCG
ATCTCCATGC
ccGAATTT1TA CAAAT1CTAG
AAAATCAAAC
TTA
T
T1CTTTA
TTTAGCTT
TTTAGCGCTA
ACCGCTGGCT
GAAAGTfl'IGC
ATI'ACATCGC
CCCACGGCA
'rrATCACTTG GGTTw1TAACC
GACTTGTTGG
CGCACAAAGT
AGGAATTTTlA
GCVTI'GCGC
RAATCCGTTT
T1TACCCCTCA
AAAGTTIATGG
TTTTAATGGC
TATTGTAAGT
TTGCATGGCT
TTCTAACGCG
GGGCATTATG
TAGcGGGATT ACT1TTCAAGC ?I'rAAGCTrIT
GCCAATTTAT
120 180 240 300 360 420 480 540 600 639 INFORMATION FOR SEQ ID No:207: SEQUENCE CHARACTERISTICS: LENGTH: 936 base pairs PtTUS 9 6/091~2 21DEC 1996 229 (BR) TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (ijj)-HYPOTHETICA-L:
NO
(iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1 .936 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:207
ATGAAAAGCG
GGGTTGAT
CGAAAAACCG
GCTGGGGGAA
GCGOTTGT1'
GGAAACATTT
CTAAAACAAG
GAATI'AGGAT
AATGCGCTTIT
TATAGAGAAA
TATCAAAGAA
GCTAACCCTA
AGAGACCATG
ACCTCCTI'AT
AGCGTATTGG
ATCCTTTCTI'
ATAAACCCTI
TCGCGCTCTA
CTAAAA.AGCA
GCGGTAAAAC
CTAGAGGGTA
TAGTTCCTCA
CGAGCGTGAT
CAAAGATCGT
TAAAACCCAA
ATATTAAAAG
TCACCTCTAT
GCAGGCTTGA
CCCCTITIGA
TGGTTACTTC
ATT1'AAAACT ATCCT 'GTAA
TTAGAACGC
TCCTTI'TCT
TGATITTTAAA
GCCCTTCAT
TCAACGGGAT
AAAAACAGCG
TGTGAGCGAA
GTITI'TAGAC
AGTCCCCCCC
CTATAAAGAA
CACTAACCCC
TGCGI'ITrA Trl'GAAGCTT
AAAAGATCTC
AGAAATTITGC
TATAAAAGAA
TA77=r1ATG
TTAATCTATC
ATCCCCATTA
TTAGAAATCG
TCTAAAGGTI'
GGCGATGAAG
AAAAGGGAGC
GATGGTTA.
TACTACCCTT
GCCCATTTAG
ACCAAACGCA
CCCAAAGAAG
TTAGAAAAAG
GTCAAATrAC
CCTAAAGTT
CATCTA
ACCCCACTCT
AATGTATTGC
TCAGCATAGG
CTCCAAGATA
TAGTGGTGGT
CCTATCTT
TAGGCGT'TrT GGTTrAAT1Tr TrI'GTTTGCC
TCATTACAGA
TGCTT
T
ITAGT
TGGT1'AAAAA
AGTITTTATCA
AAGATTGCAA
TAGAGGAGAT
TTTGCAAAAG
CACAATI'AAA
CAACTI'GATC
CCAAGAAGTG
GAGCGTTAAA
AGCCTTAAAT
AAAAGCCCTT
CAACCAATI'C
TAGCGGGTI'G
AGATAAGGAT
AACGGCTATC
A'rrGTATTr
AAATAACGCC
ATGCCTTTA
TGATCGTITAT
120 180 240 300 360 420 480 540 600 660 720 780 840 900 936 INFORMATION FOR SEQ ID NO:208: SEQUENCE CHARACTERISTICS: LENGTH: 168 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iV) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .168 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:208 ATGTCTITAG GGGCAGTGAT CAGGCT'AI TTTTGTTATA AGTTAGAGGG GGTAATATTA GA TTTAA)AGC GCATCAATT CAAATCCTAT TACCCCAATA ATAAAAATGC AITATTTATC A1CAATAAGA AAAATCCAFI' ATCTAGTRCT TCAAAGTTCA TATTGCT ~PCTIUS 9 6/091~c ~IDr C 1996 230 INFORMATION FOR SEQ ID NO:209: SEQUENCE CHARACTERISTICS: LENGTH: 684 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .684 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:209 ATGCTAGAAA CCACTATTGA AAAGTGAGCG TTTrAGAAAA
GCGAACAACC
GATTATATT
ATTTTTAAT
GGCACTTTAG
G'ITTTAGAAA
TATCGCAGCA
TTI'AGAGAAG
AATITTTGGGA
GTGGGCTTIAA
GGTGAATTTG
11 rTAATCGC
GCGATAAGGG
ATT'ITAGGGC
GGGCGTTAGT
GCGCTI'GCGT
GCGGGITTTAA
GGGTTTAAA
GCTGTTTCAA
GGGGTTATTG
GGGGGCGCAG
77rITIrCTCGT
CGATAAT'GAA
TCCTGACGTG
TGAGTGGGTG
GAATGATTTA
TAAAATGAAT
TAATGGCGAA
TGGCG7ITGTT
AGCGTGTAAA
AAACCCGCCT
TCTAAAAGAG
AATT
TACAGCAGCG
ATCTCTCAAG
AAAAATCTCG
GAGGTAGGGG
GAGGGTTTAG
GCTGGCATGA
TGGCTAGAAA
TTGAGGGCTA
AGCATGCGCA
AACGATTATG
TGGGCT1WrGC
TGAAAATCGG
AACACCAGAT
CTI'TATTAGG
GAGCGGCCAA
AGTTTIAGG
AAGAATTTGA
AAGAAGCTT
GGTTTAAAAA
AAAGCCACCC
CGGGCAGGCT
CAAAGAACAT
TGCGCCTI'TA
CATAGGATTA
AAAAAACTAC
TGCGTCTAAA
GCAATI'GCCT
AATAAAAAAT
GGGGCTAGAT
GACGCATGGT
CAAATTGCCT
TTTAGAGGGC
GCGAAT
t i~l~r 120 180 240 300 360 420 480 540 600 660 684 INFORMATION FOR SEQ ID NO:210: SEQUENCE CHARACTERISTICS: LENGTH: 267 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL; NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1.._267 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:210
ATGGCGATAA
ACACTTTCGC
TTACCAGTCG
ACATCACCAA
TAGAAGGAGA
GAITCCGGAC GCTATTTTAG
TGGATATTGA
CTCTGAAGTG CGTAAATACA ATAAAT1'CAA GGTAACTAAA ACGGACAGAA
TGCGCGGCGT
ACCTI'ATAGC GGTGAATATIT TAACCACCGT
CCAATCG
GATGCCTAAA
AAACCTGCCC
TGAATCCGGC
AGTGAAGCGC
Pe/US 18 DEC1996 231 INFORMATION FOR SEQ ID NO:211: SEQUENCE CHARACTERISTICS: LENGTH: 333 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...333 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:211 GTGTTTGAGC CGGTTATCGC TTACAAGCTT TTCCATTCCT TTGTGATTTT AGGGTGCGCG ATTGAAACTT TAACGACTAA ATGCGTGGAA GGCATCACGG CTAATGAAAA GATTTGCCAC 120 GATTATGTTT TTAACAGCAT TGGCATTGTT ACCGCGCTCA ACCCTCATAT CGGCTATGAA 180 AAATCCGCTA TGATCGCCAA AGAAGCCTTA AAAAGCGATC GCTCTATCTA TGATATCGCT 240 TTAGAAAAGA AAATCTTAAC CAAAGAGCAA CTGGACGATA TTTTCAAGCC AGAAAACATG 300 CTAAGYYCTC ACGCTTTCAA AAAGCATAAA GAC 333 INFORMATION FOR SEQ ID NO:212: SEQUENCE CHARACTERISTICS: LENGTH: 195 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...195 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:212 ATGTTGCGTT TATTAGCCCA AAAAAGCGCT ATTAAACTCA TTCTTATCCC CCCAAGCGCG AACGCTTTAG GCATCGCTTC TATTTGCGAA TTGAGCGAAG AAGTTTTTGA ACATGAAAAA 120 ATCGTAGGCA TTCGCGCTCA AGGGGATTTC ACTATCAATA GCGACGATAG GGGTTTTTGG 180 GAAAGACGCT GTCAG 195 INFORMATION FOR SEQ ID NO:213: SEQUENCE CHARACTERISTICS: PUTUS 9 6/ 091 ZU.
TPENUS IDEC 1996 232 LENGTH: 804 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .804 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:213
ATGAAAAAAC
ATTGTGTTAG
GTTI'CTCAAG
AATAAAATAG
AATATAGAAA
AATTTGCCTA
AATACCGCTA
CAAAAAGAAA
GAAAAACGAG
TTGCTCCA
GGATIGGATI
TTATTATCT
TTTrGTTTTr
TCATCATTGT
TTCTITTTACT
TGGGTTTT
GTAAATI'CCC
ATACTATCAA
AAACACAAAA
AGGACTTTAA
ACGAAGATGA
CGCAACCTCC
AACTrGAAAA
GTTCTTCTI'C
GTGAGAAGCT
CATTG'rTI'G CTAAGT11i-TC
CAAGGCTAGG
CTTAGAGCAT
TCTTTTTTAT
CACI'CATCT
TCAAGTGAAG
AGATTTAGAT
TAAAACACT!
AAAAAACCGC
CATITTCTATA
AGAATGGGCA
rrr TrCTrT
CAAATCCTTT
CCATCCACTT
TAGAGAGCTA
ATCA
AAGATCGTAA
GAACAAGAAA
TATTTGITIC
ccAAACGATG GAT?11'AATG AT1'AAACCAC
CTGGTGAT
AAAAkATAGCG
AAACCTAGTG
Trr%3AAGTTT
TTAAAAGCTT
TCTCTTT
GTGAATGCGT
AAAT'rGGCTT
TCAAAGAAAA
AAGCTTACGA
AAACTAAAAG
CGCTAGTGCA
AAAGTCCATI'
TAGCGTCTCG
M7 l'TCACAT
?TTTTGG
cTTTTATC TrTCAAGTTC
GCTCTCTAAT
CTAACAATTC
AATTATrGTG AGCTGTrAAT AGGCA~rAAG CGTrAATGAG
AAAGTTACCA
'rTTCAACTAC
TATTAGCAGC
AAAATCCAAA
TTCTTr 'ICC
AAGGGGAATA
GCTATTI'CC
AGGATTAATC
GCTTGAGI'T
120 180 240 300 360 420 480 540 600 660 720 780 804 INFORMATION FOR SEQ ID NO:214: SEQUENCE CHARACTERISTICS: LENGTH: 300 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii).MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION I1.. .300 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:214
ATGGGAGCGA
AGCGAAAACG
GTCATI'GTAG
,GATGAGGTGT
TAGCGAGTTG T'rACGCGcAT AAGAAGACAT CATIAAGGAT AAAAAGACCG AAAAAAGGCC TGTTGATTr AGGCAAGGGC TT~AGCGACCA GGAAGTCGTT
CAAATCATCT
ATTTTAAAAG,
ATTTTAAACG
GATGAAAACA
AAAGATAT'r
TAACTI'CAGA
GCATCAATAA
CTTTAGAAAA
TTCAAATCTT
ATCTCAA TTT
CAATCCTAGA
TTCTTCTAAA
TrI'AAAAGAC
TAAAGACAAA
AAAACAAGGA
120 180 240 300 PoT/ls 9 6/O~ 1PENUS 18 DEC 1996 233 INFORMATlION FOR SEQ ID NO:215: SEQUENCE CHARACTERISTICS: LENGTH: 240 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .240 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:215
GTGATGGACA
ATCAAGCCCC
ATTTI'GGCCC
ATGAAAGCCG
AACTCACTAA AAGCTIGCAA ACGCAAAAAA AACAACTCGC TGA'rrTCATC AI'AACGAAC ACATGGAARC CCCTAATGCG GCTGAAACTr AGA'ITTCCAT TAGAATGGCG AATTTTAGGC
ACTTCGCTTA
ACCCTCAAAC
TGAGCTATTT
GAAATATCGC
TTI'AGGCAAA
CATCGCCTrG
CCCTGATGAA
CCCAAGTGGT
INFORMATION FOR SEQ ID NO:216: SEQUENCE CHARACTERISTICS: LENGTH: 615 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi),ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .615 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:216
ATGCGGTATT
TCTAAGCACC
GCCAATAAAA
AACACGCCGG
ACTGAAGTAA
AGCATITGTI'
AAGGTGAGCT
TI'AGGGAAAC
ATTATCCT1T GCTA ITAGGA
,I.TAGCGAGC
TI'AGAAGCGC
CTITITTCTAA
AAAGAGAAGA
TI ITTCGCTT
CCCTI'ATAA.
?I'AGCCAAAA
ATGGGGATT1T
GCCACCTAAC
ATGAAAGAAA
?*TGAACCCTA
?I'CAA
TITITI'ATTA
GCAAACCCCT
GACTTrGAAT
TTATGATTAC
GCTCAGCCAA
ATGTI'CGGCC
GTITGATGAT
CCCTGAATAT
AAATGGCCTG
TGAGCC'ITCT
TTr 'TCATGA
AAGACTAAGG
GCCTTGCGCC
GGCACGATCA
AAAGTGGGCG
AAATGGATTG
ATTGTTTI'AG,
GTGATCCAAA
ATITCTTTCC
TTGCAAGATT
CGCTTTI'
AGCGGATCCG
AATTCAGACT
AAACCGATAA
ATAT'ITACAT
CTGCAAGGGA
GGAGGGATAT
GGTTTCAAAA
AAAACTTGAC
TAGAAGACAA
TG TrTCTTIGC
ACAAGAAGAA
CATTTACATT
AGACCACAAT
GACTAAACGG
TTrGTTGGC
TTTTAAAGGT
AAGCGGGGAA
TCAAAAAATI'
TGAAAACGCT
120 180 240 300 360 420 480 540 600 615 PCIUS 9 6/ 091 2a2a ~pLP3 4 18 D EC 996 234 INFORMATION FOR SEQ ID NO:217: SEQUENCE CHARACTERISTICS: LENGTH: 372 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .372 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:217 ATGCGCAT G AAGAPLAATGG GTCGCTCGCA TCGGTATTIW AACCTCTATG AAATGCAAGA CCCATTTTAG GGTGGGACGA TTAGAAACGA GCAACGTG3AA GGCTATI'CTA TGAACGCTAG AGCTITGAAAA AA
CGTGATI'TCT
AGCTTTCACT
AGGCACCATT
AGAGGGCAAG
TGCCGGGAAC
AGCCTTTGGC
CTAGCCTA
AACGATCAAG
AATGGCGAAA
CTCAAGTI'G
GCCCTAACCA
GCGGGCGATG
GTAACGGGGT
GCTTAAGGAA
ACAGACCCCT
GGAAAATCAG
ATCTCATT
ACATGATCAA
GGTAGAGCCG
AATCGGCGGT
AAGSGGTAAC
GCACAAATAT
AATGCAAAGA
AGAAGCCATT
INFORMATION FOR SEQ ID NO:218: Ci) SEQUENCE CHARACTERISTICS: CA) LENGTH: 279 base pairs TYPE: nucleic acid STRANDEDNESS: double CD) TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .279 (xi) SEQUENCE DESCRIPTION: SEQ ID, NO:218
GTGGAAGCGC
CAAGAG'ITCG
GCCGCTCGCA
GCTAAAGAAG
AGCCATTTCG
GTrM'rATTA
CTCACTTTGG
GTCCTTTAAG
TGTITTTGAA
CTTCCAATTI'
TGGGGACACT
ATCGAATGAT
CACCTATGCA
TTTGGGCGTG
AGGAATGAGG
TCATACITI'I'
GTGGCCTCTIT
AGAGCGATGA
GTITATI'TC
TATAG n~rC
ATTTGCATGT
TAAACACCTT
TCGGTGGGGA
ACAATTI'GAT
GGGAGTmTA
TAAAATCAAT
ATTGCAAT 'G
TTCCAACGCA
2) INFORMATION FOR SEQ ID NO:219: PO/S 96 0912 2 -EiUS 18 DEC 1996 SEQUENCE CHARACTERISTICS: LENGTH: 642 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (il) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .642 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:219
GTGGAGGAGC
TTTGAAAG
AAAGAAGCCA
ACGAA'TrAG AC 1TCAAAG
AATAGAGTCC
?I'GATGAAA
AAAGACT TI
TTGCACGGAG
GTAT1'CAAT
AAAAAAATCT
TAGCTAAAT'
TTCTCTTAAG
AAAAAGAAGC
ATITTGATAG
AAGTCAATCC
'rrAAAAAAAT
AGGGTAAAGA
TTACTI'TCAA
AAACAAGAGA
CTTATGATCC
TTTATACGAT
GATCAACAAT
TCTCGTTGTTI
GCTAGAAAAA
'ITTTAAAGCG
CGATATTATC
AAAGGATTTG
AATGGGATIG
AAGCATCAGC
AATTTTATGC
TAATGATCT
TACATGTGAA
AATAATAACA
TI'CAGTTCGT
GAAAAAAACA
ACTATCAAAA
AAAGATGAAG
AAGCATTACG
AATGTAGAAT
ACGACCAACA
GATGATAAGC
TTCAAACACA
GCGGTATATC
ATAAAAAACT
ATGGGTCAGC
CTCCCAAT'GG
ATTTGAAAGA
71"17rGACTT
ATCCAGTI'AT
TACAGATCAA
AACAACGCTG3
TATATAATGT
TTAGCACCAT
TA
GAGAGGCT
AAATGACGAT
GCI'GTTTAT
CAAGAAAGTA
CGTGATTGTC
TGAAAAAATC
TCCTGAAGTG
CITTCTATCA
TTTATI'GGCC
AGAGTCTCTC
120 180 240 300 360 420 480 540 600 642 INFORMATION FOR SEQ ID NO:220: SEQUENCE CHARACTERISTICS: LENGTH: 234 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii).HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .234 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:220 GTGGGGGGCA TTGTGGCAAA CATGAACGAT CTTTCAACTT ACATGGTTGA ATGGGTTTGT ATCTTTC TAGCGCTTTA GA'T1'GGGCG TGAAAAAAGC GCGAGCTCTT GCGCTI'ATCC TAAATACGCC CCTAACCC'rr TAAAAGAGAG AACGGCTCr1' TAGAACCAAC GAATGAAGGC TACGCTTTGC CAAACTCTCT
GAATTTACTC
CATTAATCTA
CGAI'TATTG
GTRR
POT/US 9 6/O09L1 101EA"i 1 '8 DEC 1996 236 SEQUENCE CHARACTERISTICS: LENGTH: 531 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .531 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:221
ATGAAGAAAA
GTATI'CACTC
TTAAAAATTG
TI'GGAAGITG
TTAGAAGTrr
GAAAAACT'A
GATGGGAATA
CGATTAAAAA
TGGATGGCAA
GAAAACATGT
TTI'TAGTCGT
GAAAACTI'GG
AGCGGGTI'GA
CTGATI'TGAT
AAGTCAAAGA
AATACGAGT
TATCAAGCTT
CGCCCACTAT
ATCCAAGAAA
CATI'CACAAA
CATITCTGAA
TCTCTCTTCT
TAAAAATATC
WAGAATTI'CC
AAAATCATCA
TCRCCCAAAG
GTGTTrAATG ACCC 'ITCAA
TTATACTTAA
TTC'rTCCATC
CGTTATGGCA
GACGATAAAA
AGGAATCAAA
ATTTGCTITI7
CCAGGAAAAT
TCATTATCT
ACGGCATI'CA
AACTCAATAA
AAAAACCCAC
TTGGGCGGT
ATAAAGCCAA
GGGGAATITrT
TAAAGATGT
GGCGTTCAAT
G TTGTGGCA
CATACAAAAT
CAAGCTCT
TAAAAAGCGT
GTCTrATITT
TATCTFTIT
CCCTAGAAGA
AAAGTCCAAG
T
120 180 240 300 360 420 480 531 INFORMATION FOR SEQ ID NO:222: Wi SEQUENCE CHARACTERISTICS: LENGTH: 774 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv).ANTI-SENSE:
NO
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc-feature LOCATION .774 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:222
GTGTCATGTT
GTTTATGCGG
ACTATTTACA
TCAAACGATG
GCGAGAGAAA
GTTTGTAAAT
AACGATCTIA
GGGTGTATGC
AAAGATCTAG
TTIAGGAGGGG
GGGGAGCGTC
GGGGGTITAAT
CGGATAAAAA
CTGATGGCTG
ACGCAAGAGA
TAAACGATGC
AAAATGC'FIT
TGTCAGCAAC
AATATTATTC
ATTATTTTT
AAAAAAGCGG
GGCAGAGCAA
'TTTCACTAGA
TGCAATCTIA
GAGCATTGAA
TGAAAAATGC
AGAATATAC
TTTrTTATAAC
TAAAGCTTGC
TGGTGAAGGC
TTT1TTAGGGT
GATCCTAAAG
GCTAAGAAAT
AGAGAGGTTT
AAAGCTCT'G
AAGGACTITAG
TCTAAATCTT
GATATGATAA
GAGTTALATA
GTAACAAAAG
TTTTGTTTG
AGcTTATATI' ATTTT'1GAAAA
ATTCTAGTGG
AACACACCGC
CAGAGTITTTA
GTAAGTTAAA
AGGGTTTGAA
ACGGTGGAGG
ATTTCAAAAA
GGGGCGTTGT
TTCAGGTATA
AGCTI'GCAAA
TAAAGCCATA
TACTGCTAAA
TTTAATGTA
TAATGTTGAA
AAAAGATAAA
GTGTI'CTAAA
AGCTTI'TGAA
120 180 240 300 360 420 480 540 600 PCTWU 96/0912Z1 I PEAIUS 18 D EC 1996 TATTCTGCCA AAGCTTGTIGA GTTGAACGAT GCTAAAGGGT TATAATGAGG GTAAAGGCGT GGCAAAGGAT GAAAAGCAAA AGTTGCAAGC TAGGATIAAA AGAAGCATGC GATAI'CTCA INFORMATION FOR SEQ ID NO:223: SEQUENCE CHARACTERISTICS: LENGTH: 225 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular
GPI'ACGCTCT
CGACAGAAAA
AAGAACAAAA
AGCAGCGTT
CCTT GAAAAG
ACAA
(ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc_feature LOCATION .225 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:223 GTGGCTCTCA CTI'GGGGGC TAGAGGGGGG GTGTA ITTGT TTCAITrGATr ATI'?TAAA.AC TTCGCCCTr AGAGCGCGT GGAGCGTTC TCGCTTCCAT CCCTGTGCAT GTCGTGATGA GGGGCGGGCA TTGCGTTAGA AAATAI'TA CTGCATGATA GTGGGGGGAT TATCCCACGA 'I GAAACGAA AGGGCGCATG AAAAAACTCC CGGACTTGAT
GAATA
INFORMATION FOR SEQ ID NO:224: SEQUENCE CHARACTERISTICS: LENGTH: 1263 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .1263 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:224
ATGAAAGGTT
TI'TGCAGAGG
ACTATCATAG
CAAGCTCAAG
ATTAGTAGTA
CAAATAGAGA
GCACAAAATT
GCTCTTACTA
TAACAATGAA
GGGAAACTCC
GCAAAATGGT
TCAATCAGT
GTGCTATCAC
GCATTAGATA
TGTAAGAAA
ACAATAAGAT
AAAATI'AGTT
TTTGATTGTC
AGATAGTATC
ACAAAAAGTC
TTTAGCCAAT
CAACTATGAG
CAAATACTTA
TGTCAATCTT
TTI'AGCATGC
AATGACCCAG
AAAAGATACG
AATAACATGA
CCTATGCAAG
AAI'TAAAGC
CAGCAACAAT
AAAGATCTCA
?I'rTATGI'G
AAACCCATGT
AAGAGATI'AT
TAAATACGAC
'TTTACAAAA
AAAGCATAGA
GCCCT1'GGCT
ATAACCTAAT
TAAAAGCGTG
AAGTCAAGCC
TTCTAAGGCT
TAATTCTTTG
CGCTCAGTAT
AAATTGGAAC
TAATGTCAAT
CACCAAAAAT
120 180 240 300 360 420 480 POUS 96/O9i~2.
IPEN/US 18 DEC 1996
GGCGAACAAA
GGCTATGGAA
ITGTGTAAAA
AATAACCCAG
AATAAGCAGT
GAGTrGGIG
GAAAATAAAG
GATAACGAAT
AAAGACGCTC
AJAATATTTAA
AGCGAGATI'A
AACCATATAG
TACTTTCAAA
GAT
.CCCAAACCGC
ACATGCAATC
TGGTAAACGA
AAGAGCAAAA
TAAAAGATAA
TAACTGACCC
AGACAGGTAA
TAGAACAAGA
AAAGCCAAGC
AAGAAATAC
TGACAGATGA
ACGAACAATT
ACCCTAATGT
AAGAGATGTG
ACTTGCTGGG
TAGTAATTAT
ACGAAGAT
ACTTGACCCA
TACAGCTAAC
ATGCGACCCT
AATCCAAACG
CTACGCAAAT
cAATCAAATG
TTATTTAGG
AACGCAAAAA
TAAATTTGAC
CAAAATCTCA
GAAT1'GAGTG
GAAAGCGAGC
TTGCTTAGAG
?1'TCTAAAA6A
CATAATAAGC
ATAAAAATG
CTCACACTI'G
TTCAATCAAA
CTCTI'ITIAA
CAAAATAATIG
AGAATAAACG
CAATTTGGCT
TI'CAGTCCAT
GTAGAGCGTIG
AAGCTCTTT
TAAAGAAAAA
GACTI'GATGT
AAGGGATACA
TATTrAGGAC
ATTTAATCAA
GGATTAAATT
ATCAAACAAT
ATGGCTTTGG
AAAGAGAAAG
TCCCATlTTT
TAGTGGCAGT
GGGGGAAATG
AGCAACAGGC
GGTrAATGAT
CCTACAAACT
TTA'rTGCACA
AACTCGCTTA
AGCCTCCAAT
ACTTACTCTA
GGCAATOCAA
GGAAAAAGAA
AGCTAGAATA
TAGTATATGG
540 600 660 720 780 840 900 960 1020 1080 1140 1200 1260 1263 INFORMATION FOR SEQ ID 140:225: SEQUENCE CHARACTERISTICS: LENGTH: 330 base pairs TYPE: nucleic acid STR.ANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .330 (xi) SEQUENCE DESCRIPTION: SEQ ID 140:225 AT1GAGCGTGA
GTTCAAGTGG
GATTATGATG
ACGGCTATGG
ATCGTCGTGC
GGCTTITGC
ATTITATTGGA
CGGTTATGAT
CGGCGGTGTT
TGAATATGCA
CTTTIAGTGG
TTTTGCCTTT
ATTGTI'AAAA
CCTTTATGTG
GTGCGCGGGG
AACCATCACC
AGCGTTIT
TTTCCCTAGT
CTCGCTGTGC
GTGCTITGTAA
CArrGCGGI'
AACCACTATG
GTGATATTA
CTTITAGCGGT
CCTTTAGGGT
TTGGGCTIGG
GGCCATCGCA
TI'AACGCTT
TATTTTGAGC
ATGCGGGAAG
AGCGACCCCA
TGTGGCGTTTI
AGCGATTAAA
INFORMATION FOR SEQ ID 140:226: SEQUENCE CHARACTERISTICS: LENGTH: 336 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: PCT/US 9 6 091 2 a iPE/VU.S 18 DEC1996 239 NAME/KEY: miscfeature LOCATION .336 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:226
ATGCAACTAA
AAAAAAACAA
CTAGCTTTGG
TTITTATA
CCAAAACGAT
ATTCTACCTC
GCCCCTTACA
GGAGCTTTGA
GGCTGTTGAT
GCGATGCGTG
TTGGCTTTAA
ATAGGGCGAA
AAGCGCGCTG
TTTAAGCGAT
GAGCGAAGAA
GTTTGTCAAA
GATTGCCTTT
AGATTTTAAA
TTATATTTCC
TTAATTTTTA
ATTTCTATCA
ATCGCTCAAA
TTTGATCGCT
AAAGCC
GTTACTTTAT
TTGTCATGGT
GCTACAATGA
AAAGCGTAGC
CACGTCATCA
TTATCCGGAA
TTTTAGTC
AGCGAAAGAC
CATTTTAAGG
ACATGTTTTT
INFORMATION FOR SEQ ID NO:227: SEQUENCE CHARACTERISTICS: LENGTH: 261 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE:
NO
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .261 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:227
GTGTATGCGC
TCCAAATTCG
CGCGTGGTCT
CTAACTATCA
AAGGCTAAGC
TCATGGTGGC GTTTTTTGCT TACATGAGTT TTTCTAAAAA CAACATTTCA TCGCTCTCAT CTGTGCTAAT CTTGTCGCTC AGTAGCCTAG TAACCATGCA TTTTGCCCTA ACGCTTATCA CG'TTTGATGA G
ATTGCTTGGG
CGCTTTTATC
AGTTGCGTTA
TCCTCTTTTT
GTATCAATTC
AAGCTGTGTG
CTTCTCACCC
CTTTTTGTAT
120- 180 240 261 INFORMATION FOR SEQ ID NO:228: SEQUENCE CHARACTERISTICS: LENGTH: 1257 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .1257 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:228 POT/US 9 6/ 091Tha ?-ErA/US 18 EC 1996 ATGAGGTC7'r GcGGTT7TA
GAAAATACAG
TCAGTGGGCT
TATCGTTTGA
ACCCACTAT
TACAAGGGCG
AATCCTGTAG
AGCCCGCACC
AAA7rrrAA
TTAGAAGATG
TCCAGGCCTA
GITAGAGTGA
GAAGATGTGA
ATCGCTCAAA
TATITATAAAG
GCcATGGGTG
GACTCTTCGG
GTGTATCGTT
CAGTI'CGTGG
GATAAAGATG
GGATGAAGAA
TAGGGTGTI'C
ACGATAAGCT
TTGAATGGTC
AAAAAGACTC
ATGATGAGGG
ATAAAATTI'C
AAAGCGTGTI'
CAAATCCCAG
ATGTGGGGGC
GGCAAAAATA
GCGTGATAGT
GTCAAAACCT
TAGcTTATCG ccAcCAAcAC
TCGTCGCCGT
AGACCTCTGA
ccTTGATCCA
TTGAAGCCAA
ATAAGGACAT
GTI'TAGAGTC
AAAATACTTC
TrcTACCAGG ccCAGTGGTC
TAAAGTCGCT
cAAGCTTIAAA
GTTAGAAACA
CAAACTT1'CA
TGCAAGCCT
CG LTTCTAA.A
TGTAAAAAAC
CCGCTACCAA
GGAGGGGAAA
CACACGACAA
CATITACGCT
TI'CCTATGTIG
AGATAAAACG
TAGGCCTGAA
ATGGGAAAAC
CTCCAAAACC
GAAAGTGGGC
GCACCCAAGC
ACGC T1'TAT
AATCATACTT
CATTCCATTA
GACACTTATG
AGAATCGCCA
GAGAGTTCCT
GAACCCA'TT
GAATACCCTA
TACATCATIC
CGCTTATTCG
ATCATCGCCG
ACCAAAGACT
ATrCAATTGA
TCCAATAACC
GATAAGATAG
cATCFI'GAAG
GCCCCTATCA
AACCCAAGCC
CC77-GCGrI'
GTGGCTTATC
AAAGAAGTGC
TGCAAAGTAG
ITTCAGCCCT
AAACGATTAA
ACATTGACGG
CCATTAAAAA
ACACTTACCA
TAGTAAAAAC
AAAGCGTGAA
AAAGGCAGAA
TGGAGTIT
AAAATTTCAT
TGCCCAAAGA
GTTGGGATAA
GCAACGATAA
AAAAAGACAA
GGGCGTTACC
TCACTAAAGG
CTAA.AATAGC
TrGGGAATAT
GCTATCAGGT
GTTrGTTr
TGTGTATTA
TAGTAATCAA
CGATGTGAGT
GTTGITl'M
CCCTTATGCG
ATTAGCCACC
CTCCI'TATC
AGTCTTGG
TAAAGACGGC
TGATAAAGAT
GGGGGATAAA
AATCGCTAAT
ATCCCCAGAA
ATACAAATTC
TCTCACTCGT
CAAAGAGCCT
GACTATICAA
CACTrATGcG
CACACAAAAC
GGTGAGCGTIG
AGAGCGC
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1140 1200 1257 INFORMATION FOR SEQ ID NO:229: SEQUENCE CHARACTERISTICS: LENGTH: 378 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1 .378 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:229
ATGCTTCCTA
ATAAAAGGAT
TTACAGGTI'
TTAATGATGG,
AAGAATI'TTA
GCII3GT1'G
GTCCCACAAG
CTAAAACACG CATTAGAGAT TGAGTATGGG
AAAAATTA
TATCCAGTGA TTrGTTTTCT GACTTAATGA AGCATTAGGG TGGCAGAAGT GCTGAACAAT GTAATGGT TGGTAGCAGC
TAAGACTC
CCGAACAAGC
GCTTCTI'TGT
ATGATATrAA
AAAAAA
T
I'I'A
GGATrCGATA
AAATCAGACA
AAGAACTTAC
TGGGTGGCGG
ATITITTGTT
ACTTGCCTAT
GTATCAAAAA
AAACCACTAA
ACAACCAAAA
A~CAAATCTT
CTTCCTGATG
GGACAATATC
CATGGGATCT
TAAA.ATGAGT
120 180 240 300 360 378 INFORMATION FOR SEQ ID NO:230: SEQUENCE CHARACTERISTICS: LENGTH: 216 base pairs TYPE: nucleic acid STRANDEDNESS: dc,;ble TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) A I i 1% 0"11. A# I q._qw PUT/US 9 61/0912Z7a IPENUS 18 DEC 1996 241.
(iii) HYPO THETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .216 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:230 ATGGCGAACA TGATGATGGC AGCGGCCATG
TTAGGGATIG
TATGATCAAG AAAAAGTGGA GGCTI'ATTTA GAGGAAAAAG TFI'GGCGTGT CGGTAATGGC CAGI'TTGGT
TATCGTAACC
CGCTGGAAGA CAGAAGTI'AT TTATGAAGTG
ATTGAA
ATICTTGCCC GATTGAAGGG GCTATCTAAA CACGGCAGAA AAGAGA 1TAC CCCTAAAACC 120 180 216 INFORMATION FOR SEQ ID NO:231: SEQUENCE CHARACTERISTICS: LENGTH: 333 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .333 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:231 ATGGCCGGGC TrGTrrI'GAT GACAAGGTGG
ATGCTAGCGA
TrAAAGGTI'1 CCCTCTCCAT AGTTTAGAAG
ACGTTATC
TTI'TGGCAAG TGGTGATCCA AATAACATCG CTTTCGCA
GGTGCTGCTC
AATCAC'rrGG
TGTAGCCATT
CAGTATTCCT
T'rrGGTGTrl'
GAAAGAAAGG
GCCAGTTATG
CTAAAACACA
TCGGCGATT
AAAGACACGC
GTGTGTTCAG
CAT
AAAGCTTTGT TTCTAAAI'A CAGATTITAA CGCTITAAAA TCTTGCTCAA
ACGCTACATG
CCCTATCGCA TAACCCTATT CGCTGTI'AAC CGCTGTTACC 120 180 240 300 333 INFORMATION FOR SEQ ID NO:232: SEQUENCE CHARACTERISTICS: LENGTH: 426 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) N.(iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE: NO PCT/US 9 6 091 2 IPENUS 18 DEC 1996 (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .426 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:232
ATGATTACGA
ATTAGCGATA
AATATCGGTA
TCCCCTAAAG
AGCGGTATTA
AAAGAATTGC
GTGAATGAAA
GTGTTT
TCGTTATTGC
TTAAAATGGG
AAAGAGTCGC
ATAAAAAAGA
TCAGCATTCA
AAAGCTTAAA
AGGRTTTGGC
AAAAGCGGGG
GCTTATTAAA
CAAGCTCGCT
AGAATACGAG
TGCCCCCTTA
AGATGGGGCG
TRRTTTTA
AATATAGTCA
GGAGGTCAAT
CAAGCTTTCG
CGCTTGAGTT
AATGAAAGCA
ATTTTAATCA
GAAACCACAG,
AAGYCGATAT
GGGGGGTTAT
GGGCAAAGGT
TAGAGGAATT
CGCGCGATTT
ATGTGGGGCG
ATTTGTATTA
TTTTACGCAC
TGGTTTAGGC
GGTGTATTTT
GCTTAAAACA
AATCGCTCTG
TGGGGGCATT
CGCGAGCGAT
INFORMATION FOR SEQ ID NO:233: SEQUENCE CHARACTERISTICS: LENGTH: 189 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION 1 189 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:233 GTGAATTTCA ACGCTAAAAA TATTTCAATT GATAATTTGG GGTTCTGGAG CCGGGAGAAA AGCCAGCTCT ACGGTTTTGA ATCACTAGYA GTAAAAATGC GGAAATTTCT CTTTATGATG
CAAACAGMG
INFORMATION FOR SEQ ID NO:234: SEQUENCE CHARACTERISTICS: LENGTH: 930 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori TAGAAATCAA TAATCGTGTG CTTTGCAAGC TTCAGAAGGG GCGCCACGYC AATTTGGCTT 120 180 189 PowU 9 6/ 0912.2 IpEntS 18 DEC 1996 243 (ix) FEATURE: NAME/KEY: misc_feature LOCATION .930 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:234 ATGCGAAC0C
GAATGCCAAG
GCGGGGTATG
CC ITCAAAAA
ATGTAGGGC
GTGGTG3CGTA
TTAAAAAAAA
CTTACGCC'T
GATI!TAGCGA
TATGCGCCTC
GATITGATTG
AATCGCACAC
GGATTGTI'GC
GATTTTATCC
TTGCCCGCTA
AATATI'GGAG
TCATTCTGTC
AAAAGI'AAA
GGGCGAGTC
CGAAGAAAAA
CTTATGAGCA
TCCCTI'IAAA
CCCCTAACAG
TAAAAGAAGT
ATI'TTAGCGC
ATAAGCTITTT
ACACGCAAAT
GGCATGAATT
AATTrACAG
ATAAGAAAGA
TTAATATTTA
GGATI 'CRCC
GCI'CTAAAA
GCGTTCTIWIA
AGCGATI'AAG
TrI'AGAGCCG
TCATTCTAAT
TGAACATGGT
CTTGGTI'ICT
TTCATCATrIG
GCATGCTAAC
AGGGGGCGTr
YCCTYCGAGT
TAI GATGAA
GAGCGCTCTA
AAACAACCTI'
TGGGAATTTA
CTATGATTTA
CATGCGAT
AA'I GAGTG
AAATTTCAAG
TATrGAAAG
GAAGTTAGCT
TATGGATI'
GTGAGCGCGG
TGTAAGGAAT
CCTAAAGATT
GGAGGGTGCG
TTTAGCGCAG,
TI'GCCTI'TAA
GCGTATCAAT
TTAAGGGTGC
ACGGCGAGTC
TAATGGGCAT
CTAATCATI'G
AAATTTTAGG
ATATGGCTTr
GGCGTGAAGG
TAGAAATTT
CTI'CTAATGT
ATAGGGCTAT
GCGAATACCA
GTCTITI!AGG,
GGGGCGTGAT
GAGAAGAATT
TAAGAGATGA
TI'GTGTATGG
GTGTGGGGGT
GCTTAAAA
CGTCTTGAGC
GGTGTGTATC
AAAGCGTGTG
CTTGTIGTGAA
AGAGCAAACT
AACGGGAATI'
TTAGCTl'G,
AACCGGTTT
CATTITCTAAA
TAAATACGCT
TGGCACGCCA
ATGCGGTTTG
C'ITAAAAGAC
AGTGRCTITTT
120 180 240 300 360 420 480 540 600 660 720 780 840 900 930 INFORMATION FOR SEQ ID NO:235: SEQUENCE CHARACTERISTICS: LENGTH: 564 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) Iiii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc-feature LOCATION .564 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:235 GTGGCATGCA ACACCGCGAG CGCTCTGGCT CCTATI'GTGG. GCGTGATTGA GCCAAGCATT AACGCCCCTA TTTTAGTGCT AGGGACAAAA GCCCTGAAAC AACAAGGCTA TTI'GAACATT TT'GATrGAAG AAAGTATITr AGAGGGCGAA ACTCCCTTAG AGATTTI!ACC CGAAGTGATC GCTCAAAAAA TTGAGGGCTA TI'TCATGGG ATCCATTCGG GCGATCCTAT TGTAGAATAT GCATGCACAT TCCCTAAAGT GGAATTTCAT CAAGCTAAAG AATGGCTCAP. ATTG
TTAGAAGAGA.
TTAGCGATCA
GCGACGATTC
TCGCATI'TAG
TTGTTAGAAA
ATTTTI~AGGTr cATrGCCC
TTGCAACAAA.
GCGAGCGGCG
TGCAAAAGTA
AGCGGCAAGT
AATCCAACGC
CTACTTCTCT
CTTGCATGCA
GCACGCATTI'
'I'ICCAACGCC
AATACGCCCT
ATGTGATCTG
TTCTAAAATC
GGAAGATAAA
CTATGACAAC
TITTGTGCCT
TTATTATI'rC
TCCCTTAATC
CCCCCTACTC
TAAAAACAAT
GCTAGAAAGA
120 180 240 300 360 420 480 540 564 INFORMATION FOR SEQ ID NO:236: SEQUENCE CHARACTERISTICS: N> LENGTH: 426 base pairs TYPE: nucleic acid STRANDEDNESS: double POT/U 96/0912a2 IPEA'US 18 DEC 1996 244 TOPOLOGY: circular (4i) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .426 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:236
GTGTTGTGGG
TCTAAAAAAT
AGAACCCCAC
GAACCTITITG
TTGAGCGGI'
CAAGCTGTAG
CCCCTTTTA
TATCAG
TGCTATATT'
CCATGCTCTT
GAGCCGGGGG
AGATGCCI'T
TTTTAGAAGA
GGGTCGTTG
GCT1'GCCTTA TTTrAACCAGT
TGTGGATAAC
GCTI'GGGATC
TAAGGGGCCT
cAT1'AACCTTI
CATCATI'TCA
TTCATCGCT
rrrATTTATrT
GCTAATAAAA
TTCTTCT
TTrGT'ITCT
TCATIAAGCC
TCAACGCCTT
'rrTrTATTCG
GCTCTTTGAT
TCCAAGGCTT
TTGCGTI'GGC
TAGGGCTATC
CCAAAATACG
TAGTGGTGAG
CTATTTA
TGTrI'rGTGG
CCATCATGCA
TTGTTATCTT
GCTAGTGTTT
CCTrATTITIIG CGA'TrTTCG
TGCTGGTGGG
120 180 240 300 360 420 426 INFORMATION FOR SEQ ID NO:237: SEQUENCE CHARACTERISTICS: LENGTH: 258 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori
FEATURE:
NAME/KEY: misc-feature LOCATION .258 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:237
ATGGCGTGTA
GCTTTAGGCT
CCAAAATCTT
GAAAGGAAAA
GCATGCGAAG
AATITTGCCC TAAGATCAGA
AAAACAGATT
?I'rATTCAG;T TAATAAGCTA GGGTATGCGC CACGCCCTCT TTCACGCCCT
ATTGAAAAGC
AGCGTTTTAT AGAGTTGCAA AAAGCATGCT AGGTTTTT1
GGATTTTTAT
CCAAATTCAA
CTAACAATAT
TACTTCATAL
TI'TAATCGCC
TACCCCCACT
GACTGAAGAA
AGACAAAAAG
120 180 240 258 INFORMATION FOR SEQ ID NO:238: SEQUENCE CHARACTERISTICS: LENGTH: 363 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular POUS 9 6I/G912 24 IF ',1jS18DEC 1996 (ii) MOLZCULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) -ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1 .363 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:238 GTGGATTCCA TTI'AATI'GA TGAAGCGAGA SCTCCTI'TAA TCATI''ICAGG GCCTGTGGAT AGGCGCATGG AAAA'DTACAA CAAGGCTGAT GAAGTCGCTA AAAGCATGCA AGTGGAAGTG 120 GATTI'CACCA TAGACGAAAA AAACCGCGCG ATTI TAATCA. CT1GAAGAGGG GATI'AAAAAA 180 GCCGAAAATC TCTITGGCGT GGATAATTTA TACAAAAI G AAAACGCCGC CCTATCGCAC 240 CATTTAGACC AAGCCTIGAA AGCGAATTAC CTCTTTTTIA ETGRTAAAGA TI'ATATTGTA 30 C GCCAATAATG AAGTGGTGAT TGTAGATRRA TrTACCGRCC GITI'GYYTGA AGGGGAGGCG 360 CTT 363 INFORMATION FOR SEQ ID, NO:239: SEQUENCE CHARACTERISTICS: LENGTH: 177 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .177 (xi) SEQUENCE DESCRIPTION: SEQ ID NO-239 ATGACGATCA CCACCCTATC TTTTrrATTC ACAACGCCAG AAGTGTWIGT CAATCAGGAT TrCCCATGGC j.Z CGGC TGGAAGGCTA GTGGTrrAAAG ACIGGCGT ATTTGCTGGA 120 GGCTrGTI'lG TGGCCGGATT TGATCGAAAC GCTATI'TGGA GGGTAAAGGG ?IWIVICT 177 INFORMATION FOR SEQ ID NO:240: SEQUENCE CHARACTERISTICS: LENGTH: 426 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO PO/US 9 6/19aa IPENVUS 18 DE.C1996 246 (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .426 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:240
GTG'TITTCTG
CAAGTGGCrrr
TTAGCTAGCG
GGCAATCTCG
AACGTITAG
ATCATGCCT'
AAAGCAGAAA
AGTCAT
GCAATAAAAG
TAGGGGCGTIT
GCATACAAAG
CTCCAAACGC
CGATCATTAT
TAGTAATCAA
GCATGAGCGC
GGCTATAAAT
GGCT1'TATAT
CGTGATTGGT
TAAGGGCGAT
CTrrITI'GCT
CCTCATCGGS
AGCGGCTAAT
TATCGCACGA
GTGCCTI'TGG
TACGGCTATG
CAAGGGATAG
AGC~TDT
GGGGCGTI'GC
AYTYTTGTIGG
TI'GTCAGCGC
GCAGAGAAAT
AGGGGGTACG
GAGGCTFI'AT
CACTI'CTATA
AAAAATGCTT
CGCACACCGA
CTITGTGAT'
ACTGCAGGGT
CTTTTTIATluI
CTI'IGCGATC
TTATTTAAAA
AGGCACTITCT
AGACRCCCTT
INFORMATION FOR SEQ ID NO:24l: SEQUENCE CHARACTERISTICS: LENGTH: 240 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .240 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:241 ATGCTGGTGG GTATCAGTAA CGCTATTAAT ATCATI'GACG GGITTAACGG GGGAT1'TGCG CQATCGCGCT TrrAGTCATT CATTATATAG ACCSTAGCAG T'rGCTCGC'I'1 ACATGGTGCT TGGGG'rrTAT GGTGTAAAW TTCCCTI'CAG TTAGGWCGAT CGGGGGGGCG TATTrTGG, GTTrGGTGWR CGGRATTTCT GCtTrCCATCT
TTTGTCTTGT
GAAAGATrr1T
CTCTTGCATT
INFORMATION FOR SEQ ID NO:242: SEQUENCE CHARACTERISTICS: LENGTH: 225 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: J ORGANISM: Helicobacter pylori POT/US 9 6 0 91 2 IPEAIUS 18 DEC 1996 247 (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...225 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:242 ATGCTACATA AAAAATATCG TCCTAATGTT
GCGGCCATTA
AACACATGCG AAGTTTTTAT CGCTGAGCGC ATAGACATTG CAAGGAGGCA TTGATGAGGG AGAGACCCCT
TTAGAAGCAC
GAAATTGGCA CGAATGAAAT AGAGATTTTG
GCGCAATACC
TCATGTCGCC AGACTACCCT AAGGGGCGTG GCAGTTCCCC TCTATAGAGA ATTACTAGAA
CTAGA
INFORMATION FOR SEQ ID NO:243: SEQUENCE
CHARACTERISTICS:
LENGTH: 354 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION .354 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:243
GTGATGCTAA
ATGAGTTTAT
TTAAATGATT
AGCAGAAAGG
AAAGAACAAG
AAAAAATTTG
TGGCAATTTT
TCGCCAATAT
TTGTTTTGG
C;ATGGAAAA
TAGATATTAG
ATTTTGTTAT
TACCCCTTAT
GGGGTTGGAG
TATAGAAGTG
TCATCTTATC
AGAATTTGAG
TTTTAGCAAA
ATTCTTATTT
CAAATTTTTT
GGGCTTGATA
GGTCTTTTTG
GATTTACGCC
GAGAAAACTT
TGAAAATGAT
GCAACAGAGA
GCAATGCGAG
TCCAAGCTCA
AGGCTTTTGG
ATTTTCATAG
GAAAAAGTCT
CATTAAAGAT
AAAAAATCGT
ATTAAATTTT
AAATGATACT
AAGC
120 180 240 300 354 INFORMATION FOR SEQ ID NO:244: SEQUENCE CHARACTERISTICS: LENGTH: 627 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION .627 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:244
ATGATCCGTC
CTTC TITTAA
AAAATGGGCG
AT'TACATA.G
ATTGATGAAA
AGAAACGCTA
TTCAAAGCT1'
GGAGATGCGA
I-rCAATGATC
ATI'GATAAT
TT'CAAAAAAA
TAGCCGCGTT
AAAATGTCTrr
CTCATATAGA
AGCATGCCCC
TCCCCGcTT AAGA'1'ITACG
TAGGGATTGA
GTCAATTAAA
ACAGGATTGC
TAGAATGCGC
GGAGTCTCAA
TTTTrrTAGCT
GCTCAACCCC
ATATGTTATC
TTAAAAGCG
AAGCATCGCT
AGCCAAAGAA
GTGCGAAGAA
GCAGCATTT
GATGAGTTC
GAACATI'TCT
TGGAAAT
CTCGCTTGCG
ACTCGCATAG
CAATCCAAAG
ATCAGTATTG
ATGCT*ITrrG
AGCGATAGGA
TrrGAAGACG TCTAAGA~rA
GCTGTTIAA
TTCCCAACCT
CGATI'ACGCC
AAGCTr'ITGA
ATTAGAAGT
ATCAGAATAT
CAAAAGGCAA
TTAAAGCGGT
GGTTI'TATAT
AACCCCCTAT
CTTTAGCGT
TTCAGCTTTG
AAAAAGCCGC
GGTTTTGAAA
TATTGGCGAT
CGCCAGCCI
AAGCATGGTG
TGITTCTAAT
AGAGGGATTA
TATCAAGAGT
GCCTI'TAGAA
GCTCAATCTA
120 180 240 300 360 420 480 540 600 627 INFORMATION FOR SEQ ID NO:245: SEQUENCE CHARACTERISTICS: LENGTH: 225 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION I1.. .225 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:245 GTGGGGAGT1' TGAAATTTrT AAACGCTATG GGGGTTGATT AATATCATGG TAGGCTI'TGC GAAAAATAAG ACCTTATGCG CGTI'IGAAAG CTAACGCTAA AGAAGTCATT
CAGGCTI'TAC
GAAA'ITITAA GCGGGGATAA TGAAAGCTCG GTrAAGGAGT INFO RMA TION FOR SEQ ID NO:246: SEQUENCE CHARACTERISTICS: LENGTH: 363 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .363 TAAAGGTTAA AGAGAGCGCT CGTTATrCAT
TI'AGAAGAG
AAAATCAAGG CTTGGAATTA
GCGCG
(Xi) SEQUENCE DESCRIPTION: SEQ ID NO:246
ATGGAGGCTT
ITGTGTITGT
AGGCTTITI'A
GAC'TrATGA
ATTAACGCTA
GAAAACGCGA
GCA
TAAACGCTT
TGCAAATCTI
AAAGAGAGAA
CTTrAGGGCT GcAAAGAAGA
GCGTTAAAAA
GAACGCGCAA
AGAGCCTATG
T'rrcAAGCCT TAccATI'AAT GATAT1'ATT
AGAAATII'AT
AGTGATGAGC
ATCCCCCACA
ATAGAAGTAG
GGCAAAAGGC
TTGGCTAAAA
GTGCCTAATA
AAA ITTTATG
CGGCATGGGA
ATGAAAGCGC
GCGCGGAATT
AAGAATIAGA
AACTTGTTAA
CGAGGG'ITAT
ATTGAGCGAG
'ITTGATAGAA
GAAAGTCAAT
GAAATATTTIA
TTTG'rrACC INFORMATION FOR SEQ ID NO:247: Wi SEQUENCE CHARACTERISTICS: LENGTH: 306 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc..feature LOCATION .306 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:247
ATGAAAGAAA
AATCCGGGCT
AAAGAACTGA
GATAAAAATA
ATTTGAAT
CTTGCA
GTATTAAATA
TTGGCGGGCA
TCAAACGCTA
TCTT1'GAACT
CCAAAGATYG
CTI'GCTAGAA
GAAGTTTA
CAACCCTAGC
CCAACAAGCG
TAAGCTGGCT
AGCGTGGGGC
GATCTAGTGC
TGTCTT'rrAG
GGCGTGGATG
ATTGAAGGCT
TAGTGCTT71I1
TAGAAAAGTG
AAGTGGATGG
TGGTGGT'rC
TACAGAATGT
AATGAGCGTG
CTTGAAAGT'
GGGCGTGAAT
AGGGAGTTAT
CAGACAACCT
120 180 240 300 306 INFORMATION FOR SEQ ID NO:248: (i)SEQUENCE CHARACTERISTICS: LENGTH: 393 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc-feature LOCATION .393 (xi) SEQUENCE DESCRIPTION: SEQ ID No:248 POUS 9 6I/O91? i~pjUS I b DECQ199 6
GTGCATGACG
ACCCCTAGGC
ATCATGACT
GGGATGATGT
GI'AAGGCGC
GGATTATITA
CGTGAGCCCA
GCGTGCTI'GG
?I'TTCAAAAG
TAGGGATI'GT
GGAGGGATGT
TAATCccTTA
TTIWTGCTTA
ATTACGCCAC
GTGGGTAGGC
AGAGATCTAT
GCTTTACT
GGATCAATAC
TTACAATAT
CAATATCTTT
sccTATGGCA TrCACTTTGA
TCAGGAAGAC
.TCGTCCATGT
GGGAATCTCA
AGAGGCGT1TG
ATGACAATCA
RRA
TTGCGAGCAT
'rrGTGGAI'r
GGATTGCAGG
cTI'ACCAATT
GGGGTCTTAT
cGGCAGGCAA
GTATCACATG
CCAATTIrGG
GATCACGCAA
CATT GACACG
GTATTATT
AAAATTAGAG
120 180 240 300 360 393 INFORM4ATION FOR SEQ ID NO:249: SEQUENCE
CHARACTERISTICS:
LENGTH: 1323 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (geflomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .1323 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:249
ATGATAACGC
CACGAAAACT
.TAAATAACT
GAAACCACAA
AGAAATATT'r
AAGGATGAGC
TrAGccATTA TTAI"TGCCTr
GTGAGTTGTA
TGCATCCAAA
CATGAATTAC
CTGTCTTGCA
GCCCGcAI'G
AGCGATI'TGA
ATCCATGTA'I
TTAAAAAACP
TTCATAGGG)
AAGTAT'1TGC
GGCATGTAT)
AGCAATGGAJ
GAAGCGGATJ
GGAACAGAA
GAT
TC TI'AGITI
ATCAAAACGA
ACTCTGAI'A
TAGAAAAI'T
GGTATGCTGA
ATITTGTGCT
CGGTGGGTIT
TAAGAGAGTT
AAAGCAAGCA
AATCAATGC
GCACCCCTAT
AACGCTI 'TC
AGCAGCTCGC
TAGATAAGAT
CCTC'rrCAAA
TGATAGACAA
ATAATTTIAG'I
*AACCCTAC7]
STCATTAAAA)
~GAATCTG=''
k. ATGAAGAGC'] k. AAGCCAATI'(
TGGAGCGTC
AATGCGCCAT
TAGAGCCATA
AGA.AAAGGTT
AGTGTTTAAA
TrATAAAGAT
ATTATGATT
AAGATCTCAA
AAAAGATGAA
GATGAATGAA
CACTAAGGGC
ATCTATATTI
TrCCAAAAAM
TGAAAAAATC
TTACATCATI
T'GCGATCAAI
!GGTGTCCAAJ
7TAAATCTTC'
CGCTTTAGA(
cACTATCCA! D' ACCCCCCCCI
TGGGGTTA;-
GCTTACTA?1'
TACCAGTTTG
GAAGATTACC
TTAGCCAAAA
TrCAGCGATA
TTGCATTCGG
TrATrCCTCT
GTGAAACGCT
ATAGGGGATT
TCTCGGGTTI'
AAGATACTAA
GATCACTTGA
TATGGGAGCA
CTI'TAATTG
7GAAGCGGATT
TACAGCGATG
SAAAAGCAAAC
r' AACCCCAGCC
GCTATGGGA!
r GATTGcGTT'
:GAAAATTGI
X GAAAAACAA TCGTGTCTTC T TTACCACTAT
C
TCTATAAAAT1 GACOCCACCA
G
TGGTTTAT
C
T TTATAG TTTITA'I'rIGT
I]
TCGCTCPIAGGC
TGGCTAACGA
TATTTT1TGCG
GCTCTATGCT
ACATGTTGAT
ATAAAGAAAA
ATGAAGATAA.
TTGAATrGTT
ACAAACAGGT
CT1'TAAAAGA AAGcccATGG TGAATrTGAG
TTAATAGTTT
~GAGAGGTGAA
SAAGAGAGAAC
CAAATCAGT
AATGAATT
G3GCTTAGA TrOCACCAC
:CTITTAAAA
,AATTATTTlC ~rrcAGAGT
;GATAAAAGC
TTGACAAT
:TCTATCATG
:AAAGAAGAG
TGAGCAAT'rr pr'rTrTAATG
A.AAAAGCCCT
TGCTATAGCG
GITTrGGAT
AGATTTGAA
G?1'1GGGTTA
CTATCATTAT
TTACGATTA
GGGAATGAAG
ATGTTCAAAC
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1140 1200 1260 1320 1323 INFORMATION FOR SEQ ID NO:250: SEQUENCE
CHARACTERISTICS:
LENGTH: 381 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular PGTIUS 96 09122 IPEAUS 18 D EC1996 251.
(ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE: NO (vi) -ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .381 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:250
GTGCTTCTCC
GCTTCeTrAG
GCGTTAGGGA
ATTrGGATT
CFI'ATGTGGA
CCTATATTAA
TCTGGGCAT
TITCTCGTAT
TCATI'CGTGT
G'ITCGTI'AGC
GGCGATCCAC
AATTGCTCCC
TGAAACGCCC
TTCACCAC'T
GGGTATCGCT
CGCGCCAAGA
GATGAT'TI'A
TTITGGCGTG
GCATCTACCG
GCTTAGTG
TTTrCCCACT
AACAAAAAAC
GGGTTGCCGC
ATTGCGGGCG
AGTAGAAACG
GGA'ITTATT
CTATTTrG
AACAGGCC'T
TTGGGAGGAT
TrGCGACTCT
CCGGCACGCT
TGCYTGTGAA
GTCCATCACG
AGGGCTGT'A
CATI'GGGCAA
TATAATGCTG
CGCAAGTGTT
TCATGGTTAT
INFORMATION FOR SEQ ID NO:251: SEQUENCE CHARACTERISTICS: LENGTH: 345 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .345 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:251 ATGCGCAT1TA
GCTTCTITGA
ATAGGGATIWE
CCAGAAAAAC
TI'ACAAGACA
AGCAGGCAAA
TCATAAGGTI'
TGGGGGGGCT
TT'GTGT'rGAT
GAGAAGAATA
AGCAAAAAGA
AACAAGACCT
ACTCATrT AAAATGAACG TI'GGTATGCT
TTCAATGGCG
CTTGTITrGTr TrITT'rATCC CATAGAACGG CT~
T
AAAAAAA
AGAGCAAATG CGCCTCTATC TAAAGAACAA ATGAAAAAAT
CTTITAAA
AAGGCTCTGA
GCCCTGTGAG
ACCATGAGAG
APLGCCAAAAA
ACTCA
ACTCGCGCTC
GATITGTCGCT
TTTCCAAGAC
GAAAATGATC
AGAGCGAGAG
120 180 240 300 345 INFORMATION FOR SEQ ID 140:252: SEQUENCE CHARACTERISTICS: LENGTH: 258 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) PCT/S 96/091 IPEANUS 18 DEC 1996 252 (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...258 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:252 GTGCGATCTT GCAAACAGAT TTTTGATAAG GGTTTAAAGC CCTATTATAA ACATTCTGTT TGCTTAAAGC CTTTTTTTAG GTTTTGTTTT CTCAAAATTC ATGCTTATCA ACAGCGTTAT 120 AGAGCGTTTG CTCTAACGCT CTTTTCTTGT AAGTTTTTTA ACGCTTGTAA GATTTTTATT 180 CCCATAATTG ATTTTAAAAT CGTTTTTATC CCTATTCTAA AACACCAAGC CAAGCTAAAA 240 AGAGTCTCTA ATGCCTAT 258 INFORMATION FOR SEQ ID NO:253: SEQUENCE CHARACTERISTICS: LENGTH: 132 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...132 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:253 ATGTGTGGAA TGGGGTTTAT TGGCTTCAAA ACAAAACTTA CTCAAACAAA GGCATTTATT ATATTGATCC CAATCTTTCA GGACAGAGCG GTCAAAGCGG CAACACGCTC AGCACCTATA 120 CAGCTAATTT GT 132 INFORMATION FOR SEQ ID NO:254: SEQUENCE CHARACTERISTICS: LENGTH: 1680 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: CNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori PUT/U 96/0912 IPENUS 18 D EC 1996 (ix) FEATURE: NAME/KEY: misc-feature LOCATION .1680 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:254
ATGGGGAATT
GCTATI'ATCA
TrCAACGC T
TATTIACGGGT
TATGCGCTCA
AACGGGCAAG
AATCAATACA
CCTATCAATA
cAAAGCGTGG
ATCTITGAAA
AAAGXITTTAA
AATTrAAAA
CGT'ITAGCCA
GAAGCCCTTA
AAATACTCTC
AGTITCATI'A
ATTAAGGGCG
ATCACTCAAT
AGAAGCGAGC
TCCTATGACC
GACGCTAAAA
CCCCAAGTAG
GATCCTATI'
ATCAATIG
GCGGATGTGG
GGTAATAACA
ACAGGCGGGG
TGGGCTTG
TTAATAGCTA
ATACTCAAGG
CTTCAAAAGA
ATAACAACCA
TTGATATTAA
CCGTGAGCGT
TTrTACACTTC
ACCCACAAGC
ATAGCATCRA
CTAAAGGAAG
CCACGATCGC
ATGACGCCAC
AGCTCTCTGA
AA.AACAAGCG
AAAGGAATAG
GTGGAGGTAC
TGATTGTGGG
CAGGCTCTAG
TAACCATGAG
CCCTACTCTC
TCAA'ITATGG
GCTTAAGCTA
ACAACCAATT
CCCTAGAAAG
GCAGAGACTT
CCCTAAGCTA
AGATAAGAT
ATTATAAAGA
TGGCGATTG
CACAGCGACG
AGTGGGTACT
AATCACAGGA
TGGCAAGCAC
TAAAGATGGC
CATI'CT1'TAT
CCCCACTTTA
TCAAGCTGGG
CCCTTI'AIC
TGGAGATAI'
TAATATTTA
CACTTCAACT
AT1CGCTGAT
AGTI'AAAAAT
TGRAACTrA
AGGTITATGCC
CAATGTCAAT
CTI'GAATGAG
AATCATCAPLT
CTATGATI'TC
1-rATTACATT
CAGAGCCAAT
TCGGCATI'AT
ATTCATI'AAT
TAGAGATGGT
GTI'CAAAACC
TATTAATAT
GTGTITAACC
ATCATGGCCA
TACACGCTGA
GGCAGTAGCC
ATGGTGATGA
GGTTTAG'ITG
AATAAAGTGA
AAACAATATA
GGAAATCAAG
GCTCCCTATT
GCTAACACTT
cAGATCAACA
TTCGCCCGTI'
GCGATCCCTA
AATGTGTGGG
TATGGTATCA
GCTTATGGGT
GTGGGCGTTT
ACTTGGGGAT
CAGTCTTACA
ATGTTTIAAAG
GGTI'TGTCTG
GCTGACCCTA
TTCAATAAAA
TCTATGGGGG
GGCAGATACA
TT1T'TATGTGA
ACCGGAAATA
TCAGTCAT'C
ATAATAACCC
TTGATAGCGC
TGGATAATTA
CTGACAACGG
TAGGCTTTAA
AAATCGCTGT
TCGCTCAAAT
CGATTAATTG
ATCTAGAGAG
TAGAAGTCAT
CCTACACGCA
CTGAI'TCTT
ACGCTATGGA
CGACAGGAGT
ATGWAGGGTA
ATAGCGGGTT
ATAGCCGAGC
ACAATAAAAC
GATACGACAC
ATAAAAGCGT
GTTTAAGGGG
ATAAAAAATC
ACTCTI'ATTA
ATAAAATGGT
ACACTrrI'GC
ATGCGGGCAT
TTGGTATGCW
AGTTAGTCAT
TFI'GATCCAA
TAAAGCCATT
CCTTAAGCTT
CTTAACCTAT
GGACTCTCAA
TrCTAATGAT
TCAGGGCGTI'
GCTCAATAAA
CCACTCCACA
CGCTAACCCT
GCAAATGAGT
AGAACGCTI'A
TGTGATTTTA
TGGAGGGGCT
TGATAGGTT
CCATGCAAAC
GTI'TATCAAA
'ITTCATCAAC
TTGGACGACT
TATTITTTAAA
CATTATGGAT
CGTITCTAACG
TTTTGTGATT
GCGT1I'CATC
TAGCATTATC
AGGGGCTAGG
SYATRCrTI 120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1140 1200 1260 1320 1380 1440 1500 1560 1620 1680 INFORMATION FOR SEQ ID NO:255: SEQUENCE CHARACTERISTICS: LENGTH: 423 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii),MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .423 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:255 ATGGAGTCGA ATCAWTCACT GCGGACATTA AAGGCTATAA TATGGCGTGC CGT1TACTGCT GC TTAAACA ACAGAGGCAA TTGCAATTGA. TGAGGCAAAG GACAAGAGCA AGATCGCCCC
CCCCATGGCA
CGGCTITAGTG
TT-CTACGCTC
TAAAGAAGAG
CGGCATGGGG
CAI'GTGGTG
TI'AATATCAT
GGGGAATTGA
ACTAACGGCC
GTGACTAATT
ATCAATCAAG
ATTAGAGAGG
GCTCACCTAA
TTGAAAGGAA
TATTGATI'GG
TCITGTCGGGA
TGGTCAATCA
GGAGTAGGGT
CGCTAAAGGG
TTCCAACGC
GATCACTTCG
?ITATCTITI'A
AATTAAGA
CTTCATTTCG
120 180 240 300 360 POT/US 9 6 /0912.Z ~P iDEC 19 96 CCCAATACTG ACATC ITCTr CCCTATACCC AGAGAGAATG
AAGTCATCGC
AAG
TGAGTTITI'G
420 423 INFORMATION FOR SEQ ID NO:256: SEQUENCE
CHARACTERISTICS:
LENGTH: 153 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (geflomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .153 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:256 GTGAATTI' ACCTTICGCC CAAAGATI'AC CACCACTACC ACGCCCC'I G CGATI'TAGAA ATT'ITAGAGG CTCGTTATI'T TGCGGGAAA TrACTACCAG TCAATAAGCC
CTCAITACAC
AAAAAACAAA ATCTGTTTGT GGGCAATGAA
AGG
INFORMATION FOR SEQ ID NO:257: SEQUENCE
CHARACTERISTICS:
LENGTH: 699 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv)ANTI-SENSE: No (vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (i x) FEATURE: NAME/KEY: misc-feature LOCATION 1...699 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:257
ATGGATATII'
GATGTTTCrI'
GGTAAAACCA
TATTI'AAACG
GGCTACTI'GC
CTAGCAGGGG
CTTGATGCTT
GAAAGAAGGC
GATGAGCCTT
AGCI'GATTG
TAA.AAGCAGA
TAGAAGTGAA
CCACCTTTITA
ATGTGGATTT
CCCAAGAATC
AGAGCACTTT
TTAATATCCA
GCGTAGAAAT
TTGCGGGCGT
GATTAAACAT
GCATTTAAAC AA-ACAGATTA
AAGCGGCGAA
CATGATATGC
AGCTAAATAC
CAGTATTIT
TAAAAACTCT
AGCCATAAGA
CGCTAGGGCT
GGATCCGAT
TGGCGTOGTT
GGGCTTTI'AG
CCCTTACACA
AAAGAATTGA
AAAGAGAGCG
GAGCGCAAGG
TTAA.TGAAAA
GCGGTGATTG
ATTAcTGATC
AAAAAACCAA
'TTTTAGGGCC
AGCCTAGTGG
AGCGTI'CTAA
GCGTGGAAGA
AAGAAAAAAT
GCATGAGCTT
ACCCTAAATT
ACATTCAAAG
ACAATGTGCG
TAPATGGGGCG
GGGGAGCGTT
CTTGGGCATA
GAATTTGGCC
GGAAAGCTI'G
GAGTGGGGGA
CGTGCTGTTA
AATCATTGAA
AGAGACCTTG
120 180 240 300 360 420 480 540 600 vfT/UP 9 6/ 0 9I2 AGCGTGTGCC ATAGGGCGTA TGTGATCAAA AGCGGCACGC TTTrAGCGGC
GGGAACGCTA
ATGAAATITrA TGAAAACGCT TI'GGTGCGTA AGTATTA T INFORMATION FOR SEQ ID NO:258: SEQUENCE
CHARACTERISTICS:
LENGTH: 474 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc_feature LOCATION .474 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:258 ATGAAAGAAA
TCGTTACAAT
AAGGATTI'TA
ATTTAAGCAT
AGCGGTAAAA GCACGCTTTIVI GTI'AAAATCT eITAATGAGAC ATCGCTCAGG
GCAATICCTT
CTTAAI'TAC
AAGGCATAAA
AAAATGGGGT TAGACGAGAG GCCAAAGAGT GGGCATI'ATIT
AGAGAATGTG
TCAAGAAGGG
AGGCTI'GATI
CCTTI'CAAAC
ATTCCCTCAT
CAAACAAGCC
CCTTATGGAT
AGGGGGAT'A,
TCT1TTTAACT GATrrIT1TAT
TTAGGGCTTT
AACGCTT1iTIr
TTAAACGCCT
GCTCAAAAAG
AAATTCCCTA
TCCACAGGCC
ACCACAATCG
GCGTTTTAGG
TAAAACCCAG
TACGCCAAAA
TACAAAACAT
AAGCCAAAGC
ATGAATIGAG
AGAACTCATT
CGCTATTTIT
GGAGAGCGGG
TCTGGGGAGC
AATAGGCTAT
GACTTITI'GC
CTTAGCGTTA
TGGGGGGCAA
TTAT
120 180 240 300 360 420 474 INFORMATION FOR SEQ ID NO:259: SEQUENCE CHARACTERISTICS: LENGTH: 573 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .573 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:259 ATGA ETTTCC
GCTTCCAGCT
AGTCTIWITrG
CCTAACGCTC
GACATGACCT
CCGAGCGCTT
TGAGTTITI'A
TGTCTCATTA
CTAAACTCAT
TAGGCACGCT
TCAAAACCC
TACGATITG
C ITGCAAGCG
TGGCGCGATT
TGAAGAGGTG
T'rITrAGGGT
TCITTATCGC
CACAGCGGTG
AAGGATITIT
TCTATTGTGG
TAAGCGAATT
CTATTGTT
AAATGGAAGC
TAGAAAATTT
TGGCGTTGGT
GTITTACTAC
GTTCGTGTTC
CTTGATTC
TAAAAAAACA
GCTT~wTTT PCI/US 9 6/ 0912).
IPEAItJS 18 DEC 1996
GAAAACTACC
TTAAGGGTA
GCITTrGCCTT
TCAAGCTTGT
ACCATTCCCA
GCTCCATCGC
AAGAAATCT
TGGTGGTGTr
TGCATGTTTT
CGAATAAGGT
GTCAAAAA LT TTTrA TTTGG
TTTTGATATT
AAGATGGATA
GTTTAAACTA
TTGACGCAA
GGGTTGGCA
AAGATCCAAG
GGcAcTTACG
YYA
AGCCCAGAGA
CGACTTTAGT
TGTTTTTTGA
CG'T1TTT
TTATGCGCAT
GTTITATI'C
AGATAAAGAT
GATccTTT INFORMATION FOR SEQ ID NO:26 0 SEQUENCE
CHARACTERISTICS:
LENGTH: 729 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .729 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:260 ATGG LTTTGA
AAAAAA.AATC
AGGGAAGTCA
CTCAAATCA
AT'TTrAAGCG
AAACAATTAG
GTAGAAAAAT
GACACGCT'G
ACCTITAATC
GGGAAATTGG
ACTAAACTGA
GAAGAAATAT
AAAGGGCGA
TGATTTI'CAC
AAGCATCTI'G
GTTATGG?1IT
TCCTAGAATC
T'rGAATGGCG
AGAAAAAAAG
ATAAAATCGC
TAACGAITA
TGATAGACGC
TGATATAGAG
AAAAAATTAG
CGCTTCTCTT
TAGAGCTTAA
CTATGCGCTA
ATI'TTACCTr TATITGT1'GGG TIGTGATTGA TATrrGATAGA.
GGAGTTTTGA
ATCTAGAGAG
TCATTGAAAC
GCCTAAAGAA
TGACCGGCTG
TATITTTAAT
AAGATAGCGT
TrI'GATGTTG
AAAGCGTCAA
AAGCGTGATA
CGTGGTITTA
TCTAAAGACA
ATAGACAATA
GATICTTTGA
CCCATGAGCG
CAAGCGTTAG
GCGTTAAAAA
GGCGCTI'ACC
TAAAAG TI'IT
CAGACATAGA
AACA&AGCTA
AGATAGTGGA
TCCCGCCTAA
TCGTAATAAC
TCCAACATAA
GCGTTCAGTC
AGCAGTVICT
AGTGGGTGCG
ATGCGGAATT
GccTTCAAAA
ATCAGAGCGA
ACAAGAAGAG
TAAACAAAAC
TAAAAGAACG
AGATTTGTI!A
GATAAAGCAA
CACGCTTGAT
GcTTrATGTT CAACCWTArrr ATrATCGCAA
ATCACAA.ATT
CGATCTTAAG
120 180 240 300 360 420 480 540 600 660 720 729 INFORMATION FOR SEQ ID NO:261: SEQUENCE
CHARACTERISTICS:
LENGTH: 708 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (geflomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc__feature Q LOCATION .708 FCT/IS 9 61/091 a IPENA/S 18 DEC 1996 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:261
GTGAGTGAGG
GAITCTTTGA
AATAACGATA
CATGGCTAtA
ATCCCTI'TAA
GCGGCTAATC
GCTGACACT1'
AACCCTGATG
GACAATTTGA
TI'C TACTGC
ATCAG'TI'CT
ATTGCAATCG
TCGCGAGCGT
TCCGTIATAA
CCGGTGGGGG
TCCAATC'I"I'
AAATCAAAGA
TCAACGGCGA
ATAAGGTGCT
TGAAAATCAC
TTCACACGCT
ATTTCAGGAG
TGCTCATGSG
CTATAGGGGC
GGGGGGCTTr cTTGAGTTTA
CGTTATF]TTA
AAACGATTI'A
TATAGCGAGC
TAAGGAAGTG
TAAAGCCAT
CAGCGTGTAT
CATAGAAGAA
CGCTFI'AGTG
TITATTTCRAT
GATGGTGAAT
GTGAAGGATT
GAACAAGTCG
GAAAACGGGT
GAAGAAAT'G
GTTAGGCTAG
GTGGGCGGGA
AAAGAAAAAA
GACAGGAGCG
AGCGTCATTG
GTGATI'ATCA
ATI'GAAGCGA
GCGGCGATI'G
ATGAAGTAAC
CTAACGCGAT
TTGAAAAAAT
TGGTrAAAAA
CGCCCAAACC
TI'G'TATGGT
TCGCCACCTT
AATI'GATTGA
TGCTAGTCAT
CTCTGCCTT
GCATCATGAG
TGATGGTG
GC ETCAAAAC
TAAAAATICC
TATAAGATCG
AGAAGGGGCT
GCGCAGAGGG
GCGCTATCAC
ACAAGCGAGT
AAAAGGCA'1
TATTGCGATT
AAGYGTGTGC
TTTGGGGGGC
INFORMATION FOR SEQ ID NO:262: SEQUENCE CHARACTERISTICS: LENGTH: 525 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION I1.. .525 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:262
GTGGAAACT
GTCATTAACG
GAAGTGTGCG
ACCCAATCAG
AAATACGCCA
TTAGAAAAAG
TTAGAAAATT
ATCGTATT
GAAATCGTGT
TTCTTAGAAT
CTACTGAGGG
AAAAAWTAGA
AACAGGCTAA
ATGAGAAAAA
TGGAAAAGCT
TGAGCGCTGA
TTATGGATGC
GTAAAAAAAC
TTTTGAAAAA
GGGGGCTAGG
CAAATCCAAG
AAATTTAAAG
AACGCAAGT
TCATGAAAAA
AATTGATAAC
GATACAATCT
GAGTAATGAA
GATATTTTTA
ATTAAAGGGA
CCAAAGCCTC
ATCGCCAAGA
GAAGAAGCGT
AACAAATI'AG
GTTAAAGAGC
TACAT'TrCC
ACACGCCCTA
CTAAAGAAAT
CTATCAATCT
AAAAATGCGA
TTTTAAAGGT
AAGAGTITGGA
?TTTGATGA
ACCAGGAAT
TAAATI'AGAA
GCCCTTI'AAA
TATTATCCC
AGAGATCATC
GGCAGAGTT
TTTrGAAGAA.
CAAACGATTC
GCATATCGCT
120 180 240 300 360 420 480 525 GACGGGATI'A AGGGC INFORMATION FOR SEQ ID NO:263: SEQUENCE CHARACTERISTICS: LENGTH: 678 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genornic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO PCT/US 96/O912 WbVAUS 18DEC 1996.
258 (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1 .678 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:263
ATGAAAACGC
GTTTATGTTIA
CCTAGAAGTG
TATA TITIGG
GCG'FTTGGCA
GATTTGTAT(G
CAAAAAGTGG
GTGGGACTI'
AAATACGCAA
GCGGAGYTG
TTrCA'TITTA
CTCATAAGAT
CTTGCAACGC
ATITAGCGOT
CCATAGAAGR
GCGAAAT TI
TTGGTGGGGG
TGGAATATAC
ATTTTGAAAC
TGGGCTI'TAA
TrGAAACTIT ATTTrGA GAAGT1'GCA
YAACGCTT
CTATTICTC
G~TTT'T
AAAGCCCTITA
AAGCCT1'TTG
GACGATGAAT
CGGCACCGCT
GATIAAAAAG
TAACACCTAT
CAGCGAIITA
AAGAGAGGAC
TGAAATGGAY
AAAACGCCAC
TrATI'GCTAG
GTCGTGGCGA
TTAGAAAAAC
ATCCATCCGG
TGGGTGAACA
CG'ITATGAGA
TCTTI'AGCGA
GCCTT1'CATA
GCTITI'AAGG
ATTAA'FITGC
CCAAAAACAA
CGAGCGCTIT
CAAAACCTAG
ACCATATCCC
CATTGATTAG
CGCTCAAAAA
AGGAATITAA
TT~TCTAAAGA
GCCCGAATIT
GcTrAATcAA
GTI'ATAAAAG
AAAAAGAAGA
ATGGCTCAT'
CAGCGAGCAG
TATCAAGCGA
GGGCGATTr CCCTrGACT
TCTTTTGTG
AGACGCTCAA
TGATITTTGGA
AGCTIATCGC
TTTTGAATCC
INFORMATION FOR SEQ ID NO:264: SEQUENCE CHARACTERISTICS: LENGTH: 237 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .237 (xi).SEQUENCE DESCRIPTION: SEQ ID NO:264 GTGATGGTI'r ATAAACTCCC CAAACACCAG CAAAATAAGG TCATGATTTT AGGCTTGGGC TTAGCGATGA TCACTCGTAT AGGGCTTA GGGAGCTTGT TT1CATCAG CCATTTGCAA AAGCCTTTAT TCGCTATAGC GGGCATGAGC TTTTCATGGC GTGATGTGGT GCTGCrTI!A GGGGG GGT TTrITGGCTTT TAAGGCG?1'A GTGGAATTAA AAAGAGCAGA TCTATCC INFORMATION FOR SEQ ID NO:265: SEQUENCE CHARACTERISTICS: LENGTH: 630 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) X (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO POWU 9 6/O091 2.
WpEA/US Ji8D LC 1996 259 (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .630 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:265
ATGTTGTGG
GCGCAATCCT
GCCI'GTGTT
TATI'TCGCTA
GGATI'ITACG
CAAACCCCTA
CTCAATCCTC
AACCTAGTGC
TTATI'GTIAT
TITTATGGGCG
AGGGATT
TTTTTATAGA
TGTTTATTGT
TI'ATGTGCGA
AAAACCTITA
CTI'ITrrGGC
AAAAATTATC
AAGTGTATIT
AAAAATTCGT
GCACCATGTC
TGAATCTCTT
TAGCG ITATT AGG'flTrGGT
GGAAAGGGGG
TATTGTCTTA
T1'TGAGCTTG
TITAAAAACC
CTrAAAAAAG
GGAAATGGTG
CTTCTAGCT
C'ITACGCTAT
TGTAACCGCT
GAGCAAAACC
TTAGCGATT
ATGGCTAGGA
ATGAGCATGG
7TI7 GAATT CTTrCAAA
ACCTTATTAT
TTTTTAATrG
GGCACTITAT
GGCTCTAAAC
ATCATGGGAA
C'ITTGTGCGC
ATTAGTGTT
GCGTGTTTGG
TAT7TGGGGC
CCTTTAAAAA
TCACTITAGG
GCGCGAGCGC
CGGCTGCCT'
ITTTGAACAA
CGCTCAGCGT
GGCGGTGGGG
TrTGATrI'GC
CGTGGGGGCT
AGTFI'TTACC
AAAGCAAGTC
CGTTACCTTA
TATGTCT11TT TrCT'rGGCTr
CCAAAAAATC
TAC=IIATC
INFORMATION FOR SEQ ID NO:266: SEQUENCE CHARACTERISTICS: LENGTH: 888 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: 1elicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .888 (xi),SEQUENCE DESCRIPTION: SEQ ID NO:266
GTGAAGCCAA
AAAATGATI'G
GCTAAAAAAG
AAGAGTGTCA
GCTI'ACCCTC
ATGGAATITT'
GAAAAILGACG
GTGCAATTGG
AGAAGGC'Tr
AAGGAAATAG
AAATTAGCCG
TTAAAAGCGC
GAAAAGATCA
GAAAAAAACA
ACAAGTTG
AGAGCATGAA
AAATAAGCGA
AGCCAGAGAG
GGCAAAT1TCA
AATI"I'TAAG
TATI'GCCTAA
GGCAGTTITT
AAGTGATCTT
TAGATAAAAA
AAGAAGCCCT
GTTTTAGAGA
71 I=AAG
TGCGTITTTGG
ATCAATCCGC
AGTGSTTAAA
AGAGAAGCTA
ATGGTTGCAA.
T1YIWICTCAAG,
AGCGCAATI'C
CTGTGGTITA
AGTTTATCCT
GAGAGAAATG
AATTGATGCG
CAATGACTTT
AAAGCA'ITTG
TTTTGTGCAT
CGGGGTGGAT
CTCTAAAAAT
AGAAGATTTG
ATACCTTAAT
AGAGGCGCTA
AAACTAGACG
CCGATCATT
ACAGACGCGC
'1rGCAAGTTA.
TTCCCCCCTA
CTCATGCGCT'
TI'GAGCT1'GG
ATI'IACCAGC
CATGAATATT~
TATAATGAAA
GCTPI'GAGTA
GGGGT?1'TGA
AAACGCTATG
GTAGAAATCA
TGGTGAATAT
ATGCCTTrAGA
CACCAATAGA
CGAAGTI'CAA
GGGGCAAAAA
AAAGCTTGTA
TACTCTCCAG
GGGGCATTT
AAAGGATTT
TAAAGGTI'AA
ACGCCAAAGA
AAGACGCGCT
GCTITTGTCAA
CGGAGTTITTT
TCAGCGAT
CTITAAGGATA
TAAPAGTTGTT
GGACTACCAA
TGAAGAGGGT
TGGTGCTAAC
TATAGAGCAT
CGCGCC'TrA
CAATCTGGCC
GACCGAAAGC
TTTGCAAGAA
CTCCTTGCCT
TTA
T
ITATCTA
TTTGGAGAGC
TAA.AGACAGG
INFORMATION FOR SEQ ID NO:267: PCT/US 9 6 091 22 IPENUS 18 DEC 1996 260 SEQUENCE
CHARACTERISTICS:
LENGTH: 282 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...282 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:267 GTGCTTATAA GCGTGATGAT AGGCCAAAAT CAAGTCTTAG GCTTTATAGG GACTAATTTC AAGCAAGAAT TAGTCGTGGA TTTCATTGTC CCAAGCGCTG AAATCAACAT AGGCRRTCAA 120 GTGYTAACGA GCGGGCTAGA TGGGATTTrT GGAGCGGGGG TGTTTGTGGG TGAAGTTTCA 180 AGCGTTGAAG ATCATTACAC TTATAAAAGC GCGGTGTTGA AAAACGCTTr TTTAAGCGAA 240 GCCAAACTTT TAAGGCATGT GTTTTTAAGC GGTGTGAAAA AC 282 INFORMATION FOR SEQ ID NO:268: SEQUENCE
CHARACTERISTICS:
LENGTH: 249 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...249 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:268 ATGGAAGCGC AATTACGATT TACGGGTGTT GGAGGGCAAG GCGTGTTGTT AGCGGGAGAG ATTTTAGCTG AGGCTAAGAT CGTGAGCGGG GGCTATGGCA CTAAGACTTC CACCTACACT 120 TCGCAAGTGC GTGGAGGTCC CACTAAAGTG GATATTTTGT TAGATAAAGA TGAAATTATT 180 TTCCCTTATG CTAAAGAGGG CGAGATTGAT TTCATGCTTT CAGTCGCTCA AATCAGCTAC 240 AACCAGTTT 249 INFORMATION FOR SEQ ID NO:269: SEQUENCE
CHARACTERISTICS:
LENGTH: 609 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular POTIIJS 9 6IOl IPEV' E G 1E 996 261 (ii) MOLECULE TYPE: DNA (gerlomic) (iii) HYPOTHETICAL:
NO
ANTI-SENSE:
NO
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .609 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:269
ATGCAAGCT'
GCTGTCATITG
CCTGATGACG
GCTAI'GATG
GGTGAAALTCG
AAAATGGACG
GCAAGGACTG
AATCCGGTCG
AAAGTGTATT
ACTAAAGAAG
TATCGCTMC
GGGTGGATAA
AAATTIGATGT
TCGCTACTI"I
AAGTGTTAT
'rTAAAAACGC
AACAAGAGCT
AAGTACCAGG
TrTTITTCTAC
TGGGCAGTGC
AATACATGAA
GccGGTATI'G
GGCAGAAATC
GAGCGAAGTI
TGGCTCTTGC
CCCTCCCAGT
TAT1'AATGAG
CTGTAGCT'G
TTCCACACGG
GGAGCTTGGG
TTTAGTGAGT
TrAGAGCCAG
ACGGAGCCTA
TTAGCGGATA
ATGACGAATA
CAAGCACGCC
GGCTATTATG
TGCATGGGCA
AATTTTGATA
GCGGCGTGCG,
GAAAAGCTAG
ATAGTAACGC
T'TI'GGCATG
CGACCGGCAA
T1rGGGCATTTI TrrrGGGTAGT
CGATTITGG
ATCAAGCGAG
ATCGTATGGG
CTITACTAGG
AGAGCCAAAA
CCAATACGCC
CCCTAATGAC
AAGACCCCAC
CAGAGCCTT'
GCCACCCAGT
GGCTGCCGGG
GGTTAGGGAT
TAGAGGGGCT
GAGGATCCCC
AGACAAGATC
60 1? 0 180 240 300 360 420 480 540 600 609 INFORMATION FOR SEQ ID NO:270: SEQUENCE
CHARACTERISTICS:
LENGTH: 660 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc-feature LOCATION 2...660 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:270
GTGGGCAATG
TTAGATTGCG
GAAAAAGAGA
ACTITI'AGCG
TACCAGCCTA
CTCAATCACT
AAAAGCATGT
CTGATTCGTT
GAAGCArTI.G
CCCACTATAG
GTI'TCA ETGC
CCGGGGTGGC
C7ITATATCAA
TI'GACACCTC
ACTCGCI'TT
AAAAAGTCTA
CTCAAGTGAA
TTAGCCCTAG
TTAAAGAGGA
AATGGGTGGA
GCATI'ITAI'
ATCTI'AAAGA
TTI'AGCGGGT
AGGGTTTAAA
ATCITTTAATC
TI'TGCTCTCT
TAATTTAAGC
ATI'GAAACAA
AAGTAATCAT
TITTTTCACG
TAGCT1'GAGT
TGAAGGGAGT
AAATGAGCTG
TTGATGAGCG
AAGCACGCTC
AGCGTAGAGG
AAAGAAAGGA
TATGGGGCGA
ATCAACAAAC
GCTAAGGATTI
CATTTAAACA
GGATITI'GCC
GTCGCCCATA
ACGC'TTTTAT
ATGAAATTTA
AAAATTCCTA
GTAATGTTGA
TTGAAGAAGC
AAATCAAGCA
AAGACGCTAT
TAAAAAATTI'
CGCCTTGTAA
AAACAGCCAG
TCTACAAAG
CAAATTCTCT
TTTGTGCGCT
TTATGGAGAT
AGGTTATGAA
CCTTCATTAT
CGCCGTITAGC!
CGTTCGCATT
ACAAAAAAAT
AACCAAGCAA
CGCTAAALCC
CGrITCTAATC
CAAAACGCCT
120 180 240 300 360 420 480 540 600 660 INFORMATION FOR SEQ ID NO:271: SEQUENCE
CHARACTERISTICS:
LENGTH: 744 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1 .744 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:271
ATGCAAAAAA
GTTGGTTTAG
CCCCCTATCC
ATGGGAAAAA
GAGGAATGGC
AAGGCTI'CTA
AGAATCCATG
AAAGCCCATG
AAAAGCGAGA
GGGTAI'ACT
CTcAAAACTT
CCTTATAAAA
AATAAGCCTG
GTATATTCAA
AATAACTCTG
ACGATAAAAA
AGCAGCTCCT
AGT'TAAGGCT CGATCAAGCC GCACGCAGTA
TGAGTTCCCT
TAGGAGTCGC
CCATGAAGAA
TTGAAAACAG
CCCGATAT
ATrTATATGA TrTrTATATA AGCATGAAAT
GGCCCTCAAC
ATAAAAAGGG
CTI'AACAAAA
TGCAAATTGG
GGCTTITTTTA
TCCCTCACCA
AATGGAGGAA
CCAAAGAAGA AGCCCTAAAA CGTI'GGTAGA GAAG TrGTTGGTTr
AAAAGCGTTC
TATGAAGACC
AAAATTAAAG
TGTGTGGCGT
AAGAATTGCT
GAGGGCAAAA
AAATCCCAAC
CCTAGCTTGA
AATTCGCCCA
AAAGACTCCC
cAGcTI'GAAA
TCCTCTTT
AAAATACCCC
TI'ATCAAAAT
AAATCCTAGA
TAGTCATGI'
ATGAAGCTTA
AAGTGAAAAG
CCTTAAAAAA
AAGACGCAAA
GTAAGGATTT
TCACGCATTA
ATGCGGCTAA
AAGGAATGCT
TAAAAA 'ITA
GTIAGACAAT
ACAAAGCGAA
AATAAGCCCT
TGTGAAACAA
AAAAATCAAG
GGAACCGCCT
GATCCCTAAA
TGCXAACG
TTTGATTGGC
AAGcTTTAAA 120 180 240 300 360 420 480 540 600 660 720 744 INFORMATION FOR SEQ ID NO:272: SEQUENCE CHARACTERISTICS: LENGTH: 450 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1 .450 (xi) SEQUENCE DESCRIPTION: SEQ ID 140:272 ATGCAAGAAA TCTTAATCCC TrTAAAAGAA CCTGAAATAA. AATTGAAACA
AAAAGCGCTC
SATTTGCCCT ATTTGTI'AGA
GCGCTI'GAAC
iCCGGGGAAA AATACAAAAA
TTTTCATICA
AAAAGCTATA
ATCATIAGCG
GCCT]TAGAAG
TTAGAGCGGA
AAGTGTITTTT
ATAGCATCGT
TCAGAGTGTG
TTTTrAAACAA
GGGGGAACTG
GGCCGGGTTG
CGTGATAGAG
CGCCITI'GAA
120 180 240 PT/ US 9 6/09 12a WPEAIUD L kJDCC 99 6 ATGCAAT1'AA ACCGCCATC TTTIAATGATA GCCCTTGGTG GGGGAGTGAT GTGGGG'FITG CGAGCAGTAT TATTCAGG GGGATTGATT
TTATIAATAT
TTACTCGCT CAAGTGGATG CGAGCGTGGG GGGGAAAACA
GGGATCAACA
CAAGAACCTA ATCGGATCGT
TCCACCAGCC
INFORMATION FOR SEQ ID NO:273: SEQUENCE
CHARACTERISTICS:
LENGTH: 561 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (geflomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:. No (vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .561 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:273
AAGCGATATG
TCCCTACGAC
CGCCTITATGG
ATGCGAATAC
CTrTGATTTCG
AATATAGAAA
ATCAACAGAG
GATAAAAAAG
TTATGCTACC
CCCCTTI'AG
CTCACTCAAT
GGGCG'TI'GG
TTCATTATGG
CTCTTAAAAT
ATTACAGGGA,
ATGAAACAAA
CGCATTTGAA
AACACGATIT
GGCGTTACAA
TGCCTTTAGA
AAATI'GTACA
AGGTGAGCTC
TCTCACCAAT
CGCTAAAAAC
CGCCCTTTT
TGTTCAAGCC
AAGAGATCCC
CCTTTATAAT
AACGATCGCA
TTCTAAACCT
CCATGCGATT
ATCACAAGCG
AGCTTTTI'A
AACCCCATTA
TT1'TCGCTCA AATCT1'AAAG
ATITTTAGCGG
CCGT1'ATTGG
TTAGTGGTCG
GTCCAAAACG
ATCATTTAGA
AAGATGAGGG
ACGCGCGCAC
ACCCTI'CCAT
AAACCGCCCT
GCGTTTTAGG
AAACTTTTA
TGGATTTTGC
CATCGCTGGG
TTTCCATCAA
CTTAAAAGTC
TrACGCACTG
TAGCGCGTCT
GATCCATTCC
GGIWIAAAITO
TGGGGTITAAG
CCACACAACA
120 180 240 300 360 420 480 540 561 GACGGCATGC AACAAGTTTT7 T INFORMATION FOR SEQ ID NO:274: SEQUENCE CHARACTERISTICS: LENGTH: 594 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE:
NO
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .594 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:274 GTGAGCATTA AAGAAGAGAG CCAAACCTI'A GCCGATATTA CTI'TCCAAAA TTATI'TCAGG ATG'IM7 'CTA
GAAATCTACA
TTGAACGATC
AAAGAATTAC
GAAACC'ITGC
CAACACACTA
GCGACCAACA
GGGGGGCTGT
AGGGGGCGAA
AACTCAGG
A'TTrAGAAGT
TGATCTATAA
ACGATAAGGG
ACGCTTTACT
AAGAAGCTGA
TGGCAGGCAG
ATATCATTGG
GcGGGCGTCA
CATGACAGGC
GGTGTCCATC
OAGTGAAAAA
TCAGCCCGI'
CAAAAAAGAG
AATCATCAAA
GGGcGTTGAT
CACTGAAAGG
AGGCGATCCG
ACGGCTCAAA
CCTACTAATC
GAAAAATrIG
TTAGTCGGCA
CGCATCCCTC
GACGCCGGGC
ATAAGCTCA
CATGAGAGCC
GGAGTGAGTC
CCGAAGCCAC
TAGCGATCAA
ACGCTGTGAT
CGGCTAGCAT
ACACCGT1i~
TTAAAGGGGC
CTGATGAAGT
GTAGGATTGA
AGAATT1TA
GCGAAAAGAT
CCTTAAAATr
TGAAAAGAGT
AAACGCCAAG
GGTI'ACGAT
TAAAGAACTT
CAATCAATI'A
GAGC
120 180 240 300 360 420 480 540 594 INFORMATION FOR SEQ ID NO:275: SEQUENCE CHARACTERISTICS: LENGTH: 624 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1 .624 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:275
GTGGTGGCTG
GCTGTCGTGG
ATTAAI'CTA
AATAACATGA
T1'TTGCGGTY
CSTTI'GGTCT
TATTATGAGG
AGCCACCATG
CACGTCACCG
CATGTCAAAG
ATTGAAAAAA
ATGAGGTGAG
AAAGC
TTAAAAGCAT GCAAC ?1'GTAGGCTC TAT1T1 ?I'GTCGCGCA
AGCCC
TGGCTAAPLCT CGATC CAATI'CCTlT
GAC'
GTGCGGGTAA AGAAJ CGAGCGTGCA TGCT( ATTCAAAATA
CCTA
AAAATATTGA
TALGJ
TTwCAAAApAGG
CGAA
:TCGCT
.AAGAA
LAGT
;CAAAA
ATGTG
MTACCA
~ATTT
AAGCT
AACAT
.TTTT
GAAAAAACCC AAAAAGCCAC GCGAAcGATA
GATGTGGAAG
TAcACCATCT
GTCTTTAAAA
GCCCATAAGA
GCTAACACT'
AATGATTTGG
AAAGTGCATT
TATGAAAAAC
TTCAAACCAA
AGCI'AAATC
ACAATATCAA
ACAATCTI
A
GTI!SCCGTTT
CAGGCTATAG
TTAAAGCCGT
TAATGGAAGA
AAGATGAACT
TAAAGAAATC
CACCCACGAT
CACCGTAA.AA
TAACCGGGTG
TGGCATGGTG
AGGCAAATG
AGCTITAGA.A
TCAAGAAGAT
TAGCGCTAAG
cAATAAAATC 120 180 240 300 360 420 480 540 600 624 INFORMATION FOR SEQ ID NO:276: SEQUENCE CHARACTERISTICS: LENGTH: 603 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: PuTiUs 96IO91a2.
IPENJUS 18 DEC 1996 265 NAME/KEY: misc_feature LOCATION .603 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:276
ATGAATACAT
PTGT'ITGTCG
AGCGCTTTAG
AATI'GAGCC
CCACTCTATC
AACCCAAGAG
CCC'TTTAAAG
cTAGAAACCT
TI'AGATGATT
AGCGA TTAT
CAAAAAAAT'
TAGGGGTGAG
AGCCGATTCA
ATTTAGTAAG
ACGAATTAGC
AGCTI'?TAAG
ACTGCGCTGT
GTAAAACCCC
cTTTAAATT
CACTGCGTCG
AGGTAACCCC
CATGGGCGG
TTrrAAGvrrr
GAATAAGCCT
CACCCAATAC
GCCTAATACC
CATGGCGrrTr
CACTGATI'GG
ACTCAATI'TA
TAAAGAACT'
TTGCTTTr
TGGGCCACT'
GCGCGAAAAC
TrAAACACCA
CCCTI'GTTGT
TrAAACCACC
AGAAACCAT'
CAAAAACCCA
AATGGAATAT
T GGC'TI'CTA
TGCATGATAA
CTAAAATCTA
TCTCTITAAG
CTGATGGCGG
TGAAATTTGA
AGCTCCAACC
CrTTAAAGA TrTCTACAAA
TGTATTTGAT
AATTAGAAAA
TAAAATVITG
TCAATTTGAA
CCCTTITA
GTI'TATGCTA
CCAACAAAAT
AAGCTI'AACC
TAGCCTCATG
TCTI'AAAAAC
CCACAACCCT
CCYYCAACTC
INFORMATION FOR SEQ ID NO:277: SEQUENCE CHARACTERISTICS: LENGTH: 381 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .381 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:277
ATGAGTATI'C
GTTTTGCTC
CGAGTGGGT'
GAAGAACGT'
cGTATTGACG
GI!GAGTACT
YGCWGGTGGT
AACA ITTCCG
ACCCAGAAAC
ACATCGAACT
TTCCAATGAT
CCGGGCAAGA
CACCAGTCAC
GCCATAACCA
TGTCGCCCTT
GCTGGTGAAA
GGATCTCAAC
GAGCACTI"I17
GCAACTCGGT
AGAAAAGCAT
T
A 1TCCCTI7I'
GTAAAAGATG
AGCGGTAAGA
AA.AGTTCTGC
CGCCGCATAC
CTTACGGATG
TrGCGGCATT
CTGAAGATCA
TCCTTGAGAG
TATGTGGCGC
ACTATTCTCA
GcATGACAGT
TTGCCTI'CCT
GTTGGGTGCA
T TTCGCCCC
GGTATTATCC
GAATGACTTG
AAGAGAAT'A
120 180 240 300 360 381 INFORMATION FOR SEQ ID NO:278: SEQUENCE CHARACTERISTICS: LENGTH: 237 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...237 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:278 GTGAACGTGG GCGTGCCTTT TAGCTATCAA GTGAGCGCGA CCTTTCAAAA CTCACGCCTT TCTAGTTTGC TAGAAACTTT AAAAAAGAGT TTTTTAGAAA AGCCCTTAAT TGAGAGCAGC 120 GCGAATAAAA TCGCGGATAT TTTTTCTAAA GCGGTGTTGT TTTTAGCCTT TGTGAGCTTT 180 TTATTGTGGC AATTTGGTTT GGGGGGTAAT TTTGAAAAAS GCTTTAATGG TGTGTAT 237 INFORMATION FOR SEQ ID NO:279: SEQUENCE CHARACTERISTICS: LENGTH: 147 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .147 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:279 ATGCTAATGG TTAATGGCTA TCAAATCACG ATGCATAAGG GTTATAAGGT AGGGTTTTTT ACAAGCGGTT ACAACCCTGA TTTCGCTCAA ACCATTCAAA ATAGAAGCTA TTTGATGAGC 120 TCTTATGAGT TATCGTTTTT AAGAAAT 147 INFORMATION FOR SEQ ID NO:280: (i).SEQUENCE
CHARACTERISTICS:
LENGTH: 1236 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...1236 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:280 1 p-,q POW/U 9 6/ 09i L ~PEAU8 1DEC 1996
ATGGTGCAAT
TI'AATTTATA
TrTAAGGATTA CCTAATrIG
AACCAATTAG
AGGGAAAATA
AAAACCCCGC
AAGCATGTGG
AATTITAAGCA
TATGGCCCTA
AGCGGTAAAA
TTGTATGATG
CAGATGCTAA
AGGAACAGGC
GTrACTACGC
AAACTACACA
TGCAAGAAAG
AACACGCAGA
GGTGAACCGA
GcAAAGGAT
GACATCCAGC
TrCAAAACAC
ATGCAAAATI
AAATGCTCAC
AAAAGGATAT
GGcTTTTAAT
TCTCCAAAGC
CTAAACCGCA
TCATGATAAG
TCGcTPI'AGC
ATATCCCTAG
AACTCATTCC
AGGGGCAGAG
GCGATATI'AT
GATGCGCAGC
cTCAAATCGT rrrCCTATr'GC
AGAGCGAGAT
TITTAGCCAA.
TTGTGATrI'C
TGAGTGCTT
CCACACAAAC
GCTTATAAAA
AAACAAAACA
ccAAGAAGAT TGTcAGCT
AGAAATCCCC
GATGcAAGAA AGCTCcAAAG
CTCAGGCAAG
GAATTTAAAC
AATGATGGGC
TTrAAAAGCT
TCTCAT'ITGG
TrGGGGGGAT
TCACGCAGCC
GAGTTTAGAT
GGGCATTGTA
rTTTGGCTCA GCTCCCTI 'A
TCATCCCACT
TrTAGACAAG
GCATGCTTAT
'rrCCATGCCC
TGCTATAAAG
GTCTTAAACG
GGTr1'TGTTA
TCAAGCTCTG
AAAGGCGTGA
CCCACCACTA
GGCGGTGTGG
CAAAAAGTGG
TTGCAAAACG
TITrGGCGTTT
AGAGGACCCA
SrrAGACGTGC
CAAGCCGTGC
GACGCTAAAC
GAAAATATGG
AATrCCATGA
GAGCCTAAAG
AGCGTGAGTG
GTGGAAAGGG
TCGCAT
TATCCTTI'AA
AAAATTCAAA
CGTTAAAAAC
AAAACATCAC
AGGAAACGAG
AAGCTTTGAA
AAAATCTGGC
GTAAAAGCAC
GGCTACTAGA
CTGATGTGAT
CTGTGATGAG
TGCTCATGCG
TGGTGGTGGA
CACTCAGCGC
GGAGTTT1GGA
GGAGTI'TGT
GTGGATTATr
TGCGTCTAGG
cTAAAATITT
AAAAACTAGC
AAACGCAAAT
TAcTATCATT
GATCATCTAC
CTTGCATGAC
TGCGAI'ITA
TTTGGATATT
TAAAAACATC
CACCAGCGTG3
CGCTGATGTG
CATGGATCCT
CATCGGGGC'T
AGCGATTGAG
TATGCCCCCA
AGGAATCACC
CATGTI'TAAG
GTGCGAGC.AT
AGAGGCI"IAT
GGGGGATAAG
TGAAAAAATG
cGATAATAAG 120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1140 1200 1236 INFORMATION FOR SEQ ID NO:281: Wi SEQUENCE CHARACTERISTICS: LENGTH: 267 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .267 SEQUENCE DESCRIPTION: SEQ ID NO:281
ATGGGTGTGG
GTAACTCTGG
GTGGTAGTTG
ATTGGGGCTA
AAAGCCAAAA
TGATTGGCGA
GGGGTACGGG
GGGCAGGGGC
ATGCGGTGGT
CCATCACAAA
GACCACAGAG ATTGGAGATG
ATGTTACCAT
CAAGT'rrAAG GGCAAACGCC ACCCTACTTI' TAAGGTCTTG GGCGCGAT1'T
GCGTGGGCGA
GCTI'TCAGAT TTACCCACGG
GTTCTACGGC
GGATCGT
TrATCATGGC
AGGCAACCGA
TGATGTGAGG
TGTAGGTGCT
120 180 240 267 INFORMATION FOR SEQ ID NO:282: SEQUENCE CHARACTERISTICS: LENGTH: 576 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO POT/US 9 6/O0912h IPLAIUS 18 0~ E r1996 269 (iv) ANTI-SENSE: NO (vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori
FEATURE:
NAME/KEY: misc-feature LOCATION .576 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:282
ATGCTATCT'
TTGTTACTGC
AAATACCTr
TCTCAAGAAA
GCTAACGTGA
TTGTCTCAAA
GAAAAACAAA
ATGATAAACG
ATTAAAAT
GYGATYGYCA
TTATAAGCGC
TrTTrTAGTIT
CTAAAAATCA
AAGTCGTTAG
GCGATTIITT
AAGTGGATT
AAAAAATATT
GCATTGAAAA
TAGAAAACAC
AG'ITRGAAAW
GTTTGATAAAk GGGTrTGGCT
AAAAATACAA
CAAATGGGAT
CAGGCTGGAT
AAATGGTAAA
AGAGCTI'AAA
CTATAAA.AAC
CCTCTATCAA
TTTAAAAATC
AGGGGCGTTT
AAAGATTTAG
GCCCTACAGG
AACCCTATTT
AGCACCT1TAA
AAACTCACGC
AAAACCAAGC
cAACAAGAAA
GCCAACCATI'
GCCAWT
CAATACGCCT
AAATCCAAAC
AGcAAATTGA
TGTATTTAGG
TGCAAAACAT
AGTCTAAAAT
AGCAATI'GGT
TAGAGC~TIS
CCAGTI'CGCC
TCTAACAGCC
'rrrrGTGGCT CGCTT1TAGAT
CTATAACAAC
GAGCTTGGGT
GATCAAT1'TA
GATTAATTTA
AAACACAGCG
cGATI'AATA INFORMATION FOR SEQ ID NO:283: SEQUENCE CHARACTERISTICS: LENGTH: 348 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .348 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:283 GTGCCGGCTG TrGGGG GGC GGGYATGTGA
ATGAGGYTAT
ATI'GATAGCG TGATCAAGCC ACCCTrAAAA TCAATGAAAT GGTTTTITGGG GGATTATCGT TI'GTATGAAA ATTACmTAT
TTTGAT'TTGG
TrITAYYGTT AArrTTTAATC
ATTGATI'ITC
AGGGCCTACC
TCAAAAGGAG
ATYCYTATAG
TTGTATTCCA
GTTTATCA
T1'TTCTATGA
ATCACGGCGT
CAAAAAACAT
YGAWTATGA
TTrG'rAAT
AAAAAAGAAT
TTGCTGGGAT
TTTTTATCGC
GCGAATGT
GCTTIATCAT
TGGTGTGTTG
C ITTAAAACC
TTCTCAATTTI
GTTACTGCGA
120 180 240 300 348 INFORMATION FOR SEQ ID NO:284: SEQUENCE CHARACTERISTICS: LENGTH: 489 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE:
NO
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: milsc-feature LOCATION .489 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:284
GTGGTI'GTCA
AGAGAGCAAG
CCTACAGAAG
GACAAGCALG
CGAGATATTT
TTTAAAAAAA
GGGCATCTIA
CGGTTIAT
CTCCAGCAA
TrATTTTAGT
AACGCGCTAT
AAAAAAAGTr
GCAAAGAAGC
GGGTAGAAGT
GTTATCCT
TTCTTAAAAA.
ACGAGCCAAA
GGTCGTI!ATC
TAAGCCCGAC
AGAGCCAACG
GATCAAAGAA
GATTGA ITTA
AGAGGCTAAA
CAACCATCAA
TAAAGGFFI'A
ATI'CAAAACA
ACCAAAAATA
CCTAAATTAG
AATCCTAATA
GATGAGAAAA
AACCACCGCT
GAACAAGAI'
ACGCTCATCA
GCTCTICTIT
ATTCTTTCAA
AAGAAAAACA.
CCATTrACAT AAAACTCTTr TGTrG~rACG
ATAACGACAG
ATGAGGCCCA
AAAAGAAGAG
TGAAACTAAT
CAAAGAACAA
TATCCCTAAA
TCAAAAGGTI'
CTTTGGGCAT
CAAAACTAGG
ATACAAAGCG
INFORMATION FOR SEQ ID NO:285: SEQUENCE CHARACTERISTICS: LENGTH: 120 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .120 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:285 ATGGATGAAA TCTATCAAAT CGCTAAAAAT AAAACCCTAA TCGTI'ATCGC CCACCGC~rA AGCACGATTG AACGCTGTGA AGTCATCATT GACATGAGCC AACACAAAGA
CAATCTCGGC
INFORMATION FOR SEQ ID NO:286: SEQUENCE
CHARACTERISTICS:
LENGTH: 135 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
N (iv) ANTI-SENSE:
NO
(vi) ORIGINAL SOURCE: PGT/US 9 6 0 91 2 IPEA/US 18 DEC 1996 270 ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc feature LOCATION 1...135 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:286 GTGGCGGGCA GCTTTArTTAT TGCTCTTTTT AGCGTTTTAG CGGATCAATT TGTGAGCGTG TTTCAGCATG AAAACGCCTT GCAACGCCTA TTTITCTCAAA ACGCCACCCA AAAACAAAAA 120 AAGAAGAGTT
TATGT
INFORMATION FOR SEQ ID NO:287: SEQUENCE
CHARACTERISTICS:
LENGTH: 354 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...354 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:287 ATGGTAGCTT TAAGCAACGC TCTTTCAAGG GTTTrTGGTT CTGTGGCTGG CTATAAATTC CCTTCTTTTA TCCAAAAAAG CATCAACGCT CTTTATGTTA AGATCTTTAA AATTGATTTG 120 AGCGAGTTTG AGCCTTTAGA AAATTATAAG AGTTTGAACG CTCTTTTCAT GCGCTCTTTA 180 AAAAAAGAAC GCCCCTTTGA CAAAGCCCCT ATATTTGCAT TGCGCCTTGC GATGGCTTTA 240 ATCACTGAAT GCGCTTTTTT AGACAACGAT AGCGCTTTAC AAATTAAAGG CATGCCCTAT 300 AAAGCGCATG AATTAGTGGG CGAAATCAAC CCCTTAAGCC CTCTTTTTTC TATG 354 INFORMATION FOR SEQ ID NO:288: SEQUENCE
CHARACTERISTICS:
LENGTH: 600 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori S (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...600 PGT/IJS 9 6/ 0912Z2.
IPANUS 1 8 u.t- iJJ6 271 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:288
ATGGCAGTGT
GACAACCC T
TATGATGACT
AAAATCACGC
GATAAAAGCA
GCCTTTGAAA
ATIT1'GCGTI'
GTGTTAGACA
TTTTTCTC
GACGGGAAAT
TAAAAAAGAT
'I-IGAGCCTGA
ACCTCAAAGA
TCAcTIACCA
TTGATTGGCA
AACGCTACCA
CCCCTTATAA
CGCAAAAAGG
ACATTAAAGT
ACCGCTATCT
GATAGGTTTG
AATcAAI'CC
AATCCATCTG
AGATATTGAT
CTACCCCT1'A
GATCCAAGAT
AATITI'GCGC
CCCTTTIGGAT
CGGCACGCAC
T'rrGGAAGAA GTGGCGGTr
AAGAATTTGC
GATITGCCCA
GGCTCTATCC
AAAcTrCCC TTTGATTTr rcTTTTGTGT
ATIIATCAAA
AAAGATTA?1'
AAAAACGGGG
TAAGCGTTT
AAGGGGGCTT
cGAGCGCTAG
ATTCTAAAGT
AACACACCCT
TAATGGCAAA
TAGTCAATCC
ACATGGATIT
ACCGCATCAC
CGTATGAATI'
ATTAGCCAGA
TAGCGGGATC
GATCTTAAAA
CGTGGGTATI'
TAATCAAGAC
CAACACGATG
TrATAGAATC
AAACCAGAAG
GCTCATITA
AAAACTGAAA
INFORMATION FOR SEQ ID NO:289: SEQUENCE
CHARACTERISTICS:
LENGTH: 237 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (geflomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .237 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:289 ATGGGCGGAT TCACAAGCAT ATGGCATI'GG GTCATrG'TTT TTrGGGGCTA AAAAGATCCC AGAATTGGCT AAAGGTTTAG AAAAAAGCCG TGAAAGACGA TGAAGAAGAG
GCTAAAAACG
CAAGCAACAC AAACCAAAGT GCATGAAACT AGCGAAAI'A
TATTAGTGAT
GCAGTGGGAT
AGcTAAAAAC
AAAGCAAACA
TGTGTTGTTA
TAAGAATTTC
CCTAGACGCT
AGAAAGT
INFORM4ATION FOR SEQ ID NO:290: SEQUENCE CHARACTERISTICS: LENGTH: 618 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc-feature LOCATION .618 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:290 I POUS 9 6/ 091a2.
lPENAUS 18 DEC 1996 GTGCGTTTGA ATGCGGCGGT GCAAACGCTT TAGAATACGA GTCAAACAAG CCATTGGTGA GAGTTTAACC CTATGGTGCC AAAACCCAAA AAATITTAGG GTGTrATTCA TTTrCTATAA GTGCCTGATG AAGATAAGGA GAGTI'GAACA AACTCGGCGA AGCTITAGCG AAGAAGAAGT AAAGAGCGTC CTGATGAAAT TCAGACAGCG CGAAAGGT
TGTGGTGGAT
GCcTPI'AAGC
TAACCAAAAT
TATGATTGAC
TTrATTrlATG
AAAAGTGATC
AGTGAAATCC
TTTrGAGGAAA
AAGATATGAA
CGCCACGCTC
GGCAAGTATA
GATGAATSGS
AGAGGCOATG
AACGCCACCT
1'ITrrAATCA
GTGCCTI'TCA
ATGT'1TAAG
AAAGTAGAAG
TTATITTAG
'ITTAAACTCT
AAATCGCGCT
TrAAAAAAAT
ACGTGGCGGT
TGAGTGAAAA
AGGTATATTT
GCGAACGCAT
AAATGAACGA
ATCAAMTAGG
AAAAGATTAG
TAATCAAAGA
CGAAGACGGG
CAACGYCCTA
GAGTAATTrT
AATCATCTAT
GGTG'TrTATA
GCTGGAAGTG
AGAAGAAGAT
GCTAATGCA
AGGAACCCT'
TGAAATCTCT
120 180 240 300 360 420 480 540 600 618 INFORMATION FOR SEQ ID NO:291: SEQUENCE CHARACTERISTICS: LENGTH: 294 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (geriomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylonl (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1 .294 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:291
GTGTGTTI'A
ACCCCAAGAC
GTGGCGTIVITG
TCAGAAGCTA
GATTTGGAGA
TATTGCCTTT TTGTrrAGGG AGCTCCCTAT CGTGGTGGTG AATTAGGCGC AACGAGTGCG AACGCTI'ITr AAACTCCGCT GAAAAATCAA AATGGGGCGA
GTI'TAGGCA
GATTTGGATA
GTI'GAAATCA
GA.AGTGTATG
AAAGTGGSAT
CGCAAATCTI'
AGACCACTAC
AATACCAAGT
GGGCGTTAAT
TTGCCCTTT
TAAACAAGAG
AAGCCATCAA
GACTAGCCTI'
'FITGCCTAAG
ATTA
INFO RMA TION FOR SEQ ID NO:292: SEQUENCE CHARACTERISTICS: LENGTH: 591 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori -7 (ix) FEATURE: NAME/KEY: misc-feature LOCATION .591 PUOU 9 6 /0912 2 IPENUJS 18 0ECG1996 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:292
ATGAAAGGCT
TCTrATGITrT
GGCGTTTCTA
'TrTGAAAAAA
TTTAAAC
ATAGAATTAG
ATCGCTCCCT
CTCATTAACG
ACGCAAAAT
TTATGACGC
TATGGCTTGT
TTAACAATTC
AAGAGCTTTA
ATCCTATCGC
AGCTCAAACC
TGGCTAACCC
TACTCCCCAC
GCTATTCGGT
TTAGCGCTCC
TTI'TGGGCGC
AATCTCTITA
TAAGGGGCGT
TC?'AAAACC
TCTAGCGAAT
CcCIwrTGTG TAAAGArTrG
AAACGCTAAA
CGCAGTAGAT
TAAGGGAGTA
GTrTrGGGG, rI..AACAGAAA
GGCGTGCGTT
AAAAAAGAGC
GTATTCTT
CTAGACACTG
GAATACACGC
GCTTTAGCGG
AcTT'rGTAA
CTTTATTTTTT
GTITTI'GTG
AAAGCGT!GC
I GCGATI'GA
GCCAAAGCTA
TCTACCATGA
ATAAAATC?1'
CCCAAAGAAT
AAAAATATCA
AGGTGGTTAT
TTAAAAAATC
GGCTAATGAA
GTTTATAGAG
TATGACGGAT
TCAAGAGGGC
CGCTCAAAAA
TTTTGAAAAA
ITCAGCCATG
TGTGAATATC
'rrATATTTTG
T
120 180 240 300 360 420 480 540 591 INFORMATION FOR SEQ ID NO:293: SEQUENCE CHARACTERISTICS: LENGTH: 204 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .204 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:293 ATGTGTTCTA AAAAAATAAG AAATCTCA'rr TTATGCT1G GTTTTATTTT
AAGCTTGTGC
GCTGAAGAAA ATATCACCAA AGAAAACATG ACTGAAACGA ACACGACTGA
AGAAAACACC
CCTAAAGACG CTCCCATI!CT TTTGGAAGAA AAACGCGCCC AAACTCTAGA
GCTTAAAGAA
GAAAATGAAG TGGCAAAAAA
GATT
INFORMATION FOR SEQ ID NO:294: (i).SEQUENCE
CHARACTERISTICS:
LENGTH: 279 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .279 kI (xi) SEQUENCE DESCRIPTION: SEQ ID NO:29 4 120 180 204 IkOXVpSMft EOLWIMU POT/US 9 6 /0912Z2.
1PEANS 18SDEC 1996
GTGCTAAAGA
GCTTGCAGTG
AGATCCACTA
GAAGCCAGCG
AGCGATCAqG
CATI'ATCCAT
GGGTGCAA.AA
AACTTAAAAA
TGAAAAAATr
AAAAAAACGC
ACGATTAGTC
ATTGCGCGAT
CATGAAACAA
GTTGGATTAT
CGTTTTAAAA
ATACTT1TAA
GAAAGCCACC
ATCGCTCTT
TrrGGGAGTT
AAACGAAAA
ATTCCTCCCT
GGTATGCCGAT
TAAAAGAAAA
TrTGAAGCGAT
AGCGACAAAC
AAACTTCCAT
GGGCATAGGA
AGAAAAAGCG
INFORMATION FOR SEQ ID NO:295: SEQUENCE
CHARACTERISTICS:
LENGTH: 219 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc-feature LOCATION .219 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:295 GTGGGCATTA TI'AGGGGGAT TATCCACAGG CCAGAACTCA TTTlTATTAGA TGAGCCT'?1 AGCGCTTTAG ATAGTITGAA TCGTAAGAAT TrACAGGATC TCATCAAAGA
AATACACCAA
AATTCTTGCG CTAC71rCAT TATGGTAACG CATGATGAAA ACGAGGCGCA
AAAGTTAGCC
ACAAAAACCC TAGAAATCAA AGCCC 'rAAA CAAGAGCAG INFORMATION FOR SEQ ID NO:296: SEQUENCE
CHARACTERISTICS:
LENGTH: 804 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc..feature LOCATION 1 .804 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:296 120 180 219 GTGA?1'FITA
ATGGAAITTTA
TACCTCATCC
\\CATGAATGTT
TCGCTACCGC
TCAGCGTGTC
CCCAAGAAI'
TGAAACTCAT
TCGCAACGAT
TAATAATATI'
CAGCTACACG
AGAAAAGCAC
TATTGAAAAA
TATGCGTAAA
GACAGGATCC CAGCTCCTIT CCTAGCGAAA AAGAAGAGAT GCCTTAAAGC
CTAGCGAAGT
TACACCAGAG
AAGCGGGCGT
GCGGCT'ITAA
AATACCTAGA
AAGAGACAGA.
CGCTAAAAAC
GGATATTAGC
TAGGGATTTA
AGATAACCCG
PCTf'IS 9 6/O09i2-.
i' Ig DEC 1996
CACAAAAAAG
AACGAAAAAA
GAGTATI'TAG
ATCGTCAAG
AAGA ITAGAG TCCGCCikTTA
CCTAA.AATCC
TWWAACGCTI'
GCGCTGGGAT
GGCGGACCAA AAAAAGCGAA GAGGTGAGAG TAAAGAT~iVN AACGCATGGT GT'1TGAAATI' GCTI'GGCATG GACTCCAGTG GCAAGGGGGA ATTGAAACTC TGCCTT1C TG?1'GTCAAA CTAGCGAGAC CGATGCAGAG ACGATI'GCA CTGCATGTC CGCTATGGCG
AGCG
GACAAAGATA
TGCGTCTCTA
GRCCCCATAG
GGcGGTGATG ACcGGGAGTT
GTCTTGTTGG
AATWAGAAAA
CCTAAGGGGC
AAA.AAGGCGG
TCACGCCTGA
ATGAAGAAAA
TGCTTAAAAT
TGGGCGACGT
ATAACGAAAC
AGAAAAAAGT
TACGCCTAAA
A.AATGAAGAA
TAACCTTAAA
TAAAATCGGT
TGAAGCGGTT
GATGAAAGAA
CTTAAA.AGTG
GCTGAAAGT'
GACGGCCCGA
INFORMATION FOR SEQ ID NO:297: SEQUENCE CHARACTERISTICS: LENGTH: 498 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION I1.. .498 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:297
ATGGGGTGTI
GGGCTTI'CAA
AATGACGCCA
CATGTTACGC
CATGTI'GTAG
GATAAGWTC
CAAGTGTTGC
TCCGTFI'TGG
CGTTTATCTT1
GCGTGTTGAT
AAAACCAACA
CACTAGATTT
GTATTTTAAT
AAGACGCTTT
GT'IICAAGA
ATTTGAAAGG
TAAAAAAGT
CGGTI'GCGCG
ACCAGTTCAA
TAAT'rACCCG
GCCACGCATIT
AATrAATCAA
TGAAAAAGCT
GTGGGTAGGA
AGGGTTTIATT
ATGAATCCAA
ACTCATGAAA
GTGCATAITG
CAAGTGAGCG
ATCCAAACTA
TTGAATGTGC
ATCTTAGAAG
CTAAAATGTT
GCGCTGAGAC
GAATGACAAC
'rrCAAGCCCC
ATAATCTAAA
TI'TTTGAAAA
AAGATAAGAA
ATTTGAAAAT
GGTI'GCTTTG
AA.AAAAACCA
AAGTTCTGA.A
ACAAAACCAT
ACCCTATATT
AAGAGGCTAT
AAAGATTT
GAAITTAAAA
GATTCCCATA GTCCCATT INFORMATION FOR SEQ ID NO:298: SEQUENCE CHARACTERISTICS: LENGTH: 432 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .432 PCI/US 9 6 091 22 IPEAj/S 18 DEC 1996 276 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:298 ATGGATAGAA AACTCTTAAG ATTATACCAG CCCTTAAACG CTTATTCTTA CAATAGCGAT TCGCTTTTT TATACGATTT TTCACGCCCT TTTATCAAAA ATAGCGGCGC GATTTTAGAC 120 ATAGGCTCAG GGTGTGGGGT TCTAGGCTTG CTCTGCGCTA GAGACAACCC GCTAGCGAGC 180 GTTCATTTAG TGGAAAAGGA TAGCAAAATG GCGTTTTGCT CCCAAAAAAA CGCCCTTAAA 240 TTCCCTAACG CTCAAGTGTT TGAGAGCGAT TTTTAGATT TTAACCCTCC GATTTTGTAT 300 GATGCGATTG TGTGCAACCC TCCTTTTTAT GCTTTAGGAT CTATTAAATC TCAAATTAAA 360 GGGCATGCGA GGCACCAGAG CGAATTAGAC TTCGCTTCTT TGGTGGCTAA AGTGAAAAAA 420 TGCCTGAAAC CC 432 INFORMATION FOR SEQ ID NO:299: SEQUENCE CHARACTERISTICS: LENGTH: 141 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION .141 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:299 ATGTTGAGTG CGTTGGTGAT GCTGCCTT ATGGAGGTTT TTTATTATTT CAATTTTCCG TTGTGGCTCA ATCTTTTCTT AGGGCAAACC ATTGGAGCGG TGATTTTTTT CAAGTTGGAT 120 AAGTTGATTT TTTCTAAAAA A 141 INFORMATION FOR SEQ ID NO:300: SEQUENCE CHARACTERISTICS: LENGTH: 387 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION .387 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:300 LTGAATACTA TTATAAGATA TGCGAGTTTA TGGGGCTTGT GTATTACTCT AACTCTAGCG P~UN/S 96 09122.a !"0P2 18 DE C1996
CAAACCCCCT
AA'ITTAAAGC
TCGCCTAAAG
GATAAAGCCG
CAAGCGCAAG
G'rITGCCT
CTAAAACCCC
TCATI'GATYC
AAACAGCGAC
CTrI'GGGGCT
AACTCAGTGT
ACTI'TGAACG
TGSATGAAATC
GCCGACAAGT
CACGATCAAT
TTATGAATTG
CAAGCAAGCG
CGAG ITA
AAGCAAATCC
TCITTARRAG
CAAGAGATCG
CTAAAGGGGG
ATGGAAGAAC
TTAACAATI'A
CGACACCGGG
CTAAATACCA
CTACCACCAA
CACACCATCG
TAGCCATAAG
TTrTWWCCC
TGAAAAAAGC
TCTCAGTIG
CCAAAGCGAT
INFORMATION FOR SEQ ID NO:301: SEQUENCE CHARACTERISTICS: LENGTH: 726 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .726 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:301
ATGGTTTTGT
CTTTTAATCA
TACAATGGCG
TACGCTCATT
TATTTTCTTA
ATI'TTTTACA
TTAGAAGAAT
ATGCTTTTAT
GGGGTCTTr
ATAGCCAGCA
AAGCATTATC
TTTGCCACCT
GAATGC
TI'CTATCCAT
ATCTTGGCCC
GGAGTATTGT
CTCAAGGCI'
T T*T'TGGAT
CCCCTTTAGT
TIGGCTCTAT
TCTI'AGCGGT
TITTCTATAGT
TGATTTITCAA
GTTTrCGT'r
TGI'GCAAAC
'TTTTAAAAAA
TATCCTI'FIG
GAATATGC
'TTTGCCGGT
CGTAATICTT
GGTCTCTTAT
CC2TTrITCT
TTTAACGCCC
CCCGCATTTC
CCATCAAAGC
TTTGCTAT
CCTAAYGCTA
AGCTI'AATG
AGTTI'GGCGT
CAAACTITAT
GTG'ITCGCAT
T1'GAGTAG
TI!GCACCAAA
ATTAAATAT
CTTTATTTCA
CYCTTTTTCA.
TATCAAAATT
CTTTITTTCCT
ACGCACTACY
ATITTAAG
TTTGGAGC
TACCGCAATC
GGG?1WTTTAA
TCATCAATAT
AATATTATCC
7TTAAAATC TTCCCTI'rAT
AAAACACCAT
TACTCAAACA
T(GATTCCTTT
TITTATCTT
CGCTAGAATG
TATC'FT1'AT
TTTGAATGAT
AGCGTTAGTG
T1'TTGCGTCT
CCATGTCGTI!
GCTCACTTTT
AGGGGTCTIT
GAGTrGGAT
GCACCGATTG
TTTTAATTTT
TAAAGAGAAA
120 180 240 300 360 420 480 540 600 660 720 726 INFORMATION FOR SEQ ID NO:302: i)SEQUENCE CHARACTERISTICS: LENGTH: 378 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature POUS 9 6 /0912Z "'IS 1i8DEC 1996 LOCATION .378 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:302
ATGCAATACG
GCAAAACTCA
TGTAFI'GAGA
'rrCACGGAGT
ACAGGCTI'AT
AGTAAGATI'G
CATCAGATG
CTAACGCTTA
TTGAAATGCT
ATGAAGACAT
TGTI'GAATAT
ACACccATCA ATr'rGGTGTI'
AACTCGCC
TCAAGCCTAC
TrATGAAGGG
TGAAAAGAAG
TTTAGACTAT
AATCAAAGT'
GAATGTGGCT
CAGCATAACC
AFI'TIAAGAT
ATCTATTATA
GAAAAAGGG
TrAACGCAAG AGGGGGrIGT
GAGTGAGTGT
ITTCTTCGCA
TI'AATAGGGT
GGRAAGTGGC
ccAATGTGGA
TAGAGGCATG
GGAATCCCCG
AGCCAAACGC
TACGGATAT
GGTGTATCT'
AAATIGACGCG
G-AGGGAAATC
120 180 240 300 360 378 INFORMATION FOR SEQ ID NO:303: SEQUENCE
CHARACTERISTICS:
LENGTH: 429 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1 .429 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:303
ATGATGTTTG
TTAGCTGGGA
TCTI'ATATI'
GTTTTAA
ATGTCTATGG
GGGATTGTGA
AAAACCCAAA
TiTi'rTGGCA
ATAACACGCT
TITAACTrT
CGCAAATTTC
AATCCTTGAT
CCAAGCTI'AT
TCCTITTGG
GCGTlTGGTl1T
TATCAATITA
TTTAAGCCCT
TrI!AGAGGAT
GTTTGTGGTG
CCATAGCTT'
TrTGCAT
AGCGAGCAAA
'I TGAGACAG CGCCTCTTI' TGCGTGTI'GC
CTTTGATCCC
ATrAAAGATG
GTAAGGCTAA
GGGTITCC TCGTGTT1 TCGTriTI'CT GGGTGAATITA TTAGGCGTGT TrCGTITGC TCTAACAGCA
TGCAGCGCTT
AACYTCGCTIT
GGCGTATATG
AAGGGT'
G
GGGCGTGGGC
TATCGCTGGG
ATTrTGTAT
TACCCCTTTC
120 180 240 300 360 420 429 INFORMATION FOR SEQ ID NO:304: SEQUENCE
CHARACTERISTICS:
LENGTH: 252 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature POUS 96/091Z22 IPENUS 18 DEC 1996 LOCATION .252 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:304
GTG~CTGGTGG
TTrATCAAGC
GTAGAAGCTT
GATGGCCGGT
TTAAAAAAGG
TGGGCAAACC CAACGAAAGC
TATGCAGATA
TTGTAGATTIT TAAGGGCGAA ATCGTTrA ATGAAAATr AGAGCATG
GGTAAGAAAA
TAGACTCTTI GAGCGCTTGT AGGA TTAG c
CCCACGCCCG
TCAATGAAGA
ATAAGCGGAT
AGCGCTATT1G
CATTGAGCAT
TAATTCTAGC
CGCTACCAAA
CCAGCAGGT
INFORMATION FOR SEQ ID NO:305: SEQUENCE
CHARACTERISTICS:
LENGTH: 465 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .465 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:305
ATGCGGATAT
TCITGGGGTA
GACTACGCTC
CAAGTGGCTA
cccAGAACT'
GTCATCAATA
TCATGGCTI'A
AGAAAGCCAC
TAATTCTCAA
TCAATTTTTC
ATGCCAATTC
GTCAAAI'CT
TTGAGCCGAA
ACGGCATCAT
TGGCGASACC
TTCTTTCCAA
TTTrGAAAAAC
TATTAAGCTT
TGGGAA.ACAA
CATGCTCACT
GAGT1'TGGGG
GAGCTI!TGAG
TTTTTATTCA
CCAACGCTAC
AC'ITTGGCTT
AAAAACCCTA
GAAATCAATC
TATGGGGGGG
GCTITIGGCG
GGCATTAG
ATGTGGGGGC
GATCAAAGGC
ACGCC'TTAT
ACTATAATAG
GTTTAACAAA
CTATGGACGT
GGATACAATT
GGGAACAAGC
TCGCM
TTTGACGCGC
GGGGTIT ITT
CGAAGCGGCG
CATTGCCGAT
GATGGTTAAT
GGCCGGCAAT
CCTTGTGAGC
120 180 240 300 360 420 465 INFORMATION FOR SEQ ID NO:306: Ci) SEQUENCE
CHARACTERISTICS:
LENGTH: 513 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .513 POT/US 9 6 /0912a2a IPENUS 180E C 1996 280 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:306
ATGAATGTCA
GAGAAACTI'G
cAATTAGCGA
ATGAGTAAAA
CAAAGGCCTA
CAAAATCAAT
GAAAGTTTG
GTCAATAACA
TGCTG3GGAAT
AAAAAAAGGA
GGAAAGAAAA
TCCCCATI'CC
crTTrTATGA
TTGAGA'ITGA
TrAATGAAGT
ATGAGCTGGR
AGATCCAAGA
TTATCACTAG
AAAGCCACAA
CACTACTri
TGGAGTI'GGA
TGTCTCGCTA
AAAAGAATGC
GTI'TGAGCGG
GAGGGCGC LT
GGGQATGGGT
ccGTAAAGAG
AGTGGAAAGA
TrAAGCAGTA GTGCTcATI'G
ACGATTITCA
CGTGAGAGTA
TATTTTCATG
TGTGCGGGCG
CAAGAGTI'GC
GGT
TTGATAGGGT
TAGCTATGGG
GGGGCTTTGT
AAGAGGCTAA
TCAGACAGT1
GGACTATAAA
ATGCGGATI
TGTTI'GACAA
GGATTGTIG
GAGCATI'GGT
GGGTGGGGTG
ATI'AGCGCGT
AGAGATGTAT
ATI'CTITAAT
GGCTATAGCA
TAAGCAAGAG
INFORMATION FOR SEQ ID NO:307: SEQUENCE CHARACTERISTICS: LENGTH: 423 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .423 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:307
ATGTGGCCGT
GTGGCAAAAA
AATAGATCCT
T'TCATTAGTA
ATTGTGGCTA
ATGAACTACC
CAAGC TI'AG
GCC
RAAAGCTTr
ATATAAAGAT
TAATCTTTTT
TCACTGCTTT
TGGCGATCAT
CCTI'AACGCT
AAAAAAAGTT
TCTAAAACCC
TGTTGCGCTA
CCTTATCAAG
G'rrAGCCT'rr
GAACGGCATG
CTATACCACA
CCCTAAT'TG
CTAAAAGAAA
AAAGCGGGCC
cGTTIATTTGC
TTTGGCGTGG
AGTAAGGAAT
AGCCCTTATG
CCTTT'ITCAG
CGAGCCTTGC
TAAAAAGGGC
GTTrGATAA
CGGTTGGCGT
TTGAAAAAAA
GGATCAGCGA
YCCCTAI'TTG
CCTTGTGGGA
TTATTTGCCA
AAGCCAGCCT
GATGGTTTI!A
GCTTTTTGTG
AGAAGTGGT'
CAAACCCAAA
120 180 240 300 360 420 423 INFORMATION FOR SEQ ID NO:308: SEQUENCE CHARACTERISTICS: LENGTH: 210 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature PCT/US 9 6 091 22 IPEN USi L DEC 1996 281 LOCATION 1...210 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:308 ATGGTATCGT TGCTTGGCGC GCTTAAACGC ACCCCTTGCA CTAATCGCTT TTATCTTAAA GCACTACTAT TTGCTATATT CTATCATGCA GTAAATAATT TTCTAACGCA ATGCCCGCCC 120 CATCAAGTCC GGGAGTTTTT TTCATCACGA CATGCACAGG GATGGAAGCG AGAAACGCTC 180 CCATGCGCCC TTTCGTTTCA AAACGCGCTC 210 INFORMATION FOR SEQ ID NO:309: SEQUENCE
CHARACTERISTICS:
LENGTH: 459 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...459 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:309 GTGCATCATT TGYAACGGCT TTAGACTCA GGCTCTGAAA GGTGTATAGG CTGTGGGCTG TGCGAAAAGA TTTGCACGAG CAACTGCATA AGGAAAATGTTCA CGCATAAGGG CGAAGACAAC 120 CGCAAAAAGA TCGAT(2CTA CACGATCAATTTGGGGCGTTGCATTTATTG CGGGTTGTGT 180 GCGGAAGTTT GCCCAGAATT GGCGATCGTT ATGGGGAATC GGTTTGAAAA CGCCAGCACC 240 CAACGCTCCC AATACGGCTC TAAAAGCGAG TTTCTAACGA GCGAACAAGA CGCTAAAAAC 300 TGCTCGCATG CCORGAAT AGGCTNISM: TGGT GCGGTAAGCC CTAATTATAA CGAACGCATG 360 CAAGCCACCC CTTTAGATTA TGTCCAAGAA CCTTCAAAAG AAGAATCCAA AGAAGAGTTT 420 YCCACAAGCC CAGAAAGCCA TAAGGGAGAT GAAAATGTT 459 INFORMATION FOR SEQ ID NO:310: SEQUENCE
CHARACTERISTICS:
LENGTH: 549 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .549 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:310 t At1 -n tt- POUS 9 6/ 09122a IPEA/IS 18 DEC 1996
ATGGCTAIT
CATGAGTTGG
TrATCGWr1
GAATTGATT
CTGGAATrhC GAAAA ITTAC
TGCCTAAAAA
GGGA AAATCC
ATCACGCCT
TTGAAATTA
GGGGGTGGTG
TrrrAAGATC
CTTATAAAG
GGTTAAATTC
TCAAAGCGCT
TTGAATTGGA
AACAAAGCCT
TAGccTI"ITr
TAGACATI'AA
T'1-IrTAT TrATCGTCCT CCAAGCT1'TA GGGTTrGAAA GTTTATII'CT
AAAACCAAAC
TGGCTI'GAT TrTCACGCT GTATFTTAAA 'rrAGAAAAAT GCAAAAGGAT
CGCATCATCG
GATAGCGCCT
CAAACTTACT
TGGCGTGGCA
AGGGATAAAG
GCGTTATGAT TCCTI'CA7I'G
TGATGTGGGG
CGCGCTI'AGT
GcTCTTTAGC
TGAACGTI'GA
TAGAGAGCCT
CTTTAGGGCA
ATGGGCGTTG
ATTTITAGA
T'rGATAGCGA TrcAAGCATG
CCAGTGCGAT
GGTGTTAGAA
AAATGACACT
GCTTTAAAA
TGGGCTAGTT
COTOTTAGAG
AATCACTCGC
AAGAAAAGGC
INFORMATION FOR SEQ ID NO:311: SEQUENCE
CHARACTERISTICS:
LENGTH: 201 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .201 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:311 ATGCCGGAAA ATTCTAAACT ACAACCTGCT AAGTTAGGGA AAAATTTTGA
CCCTGTGGAT
CATTCTAACA GGAATTrrIT.7 CTTTTCTCTC ATI'CTGTCTG TATTGTTACA
CTGGTTGATT
TATITITTAT TI'GAACACAG AGAAGATTrT TrrTCCTTCAA, AACCCAAGCT
CGTTAAATTA
AATCCTGAAA A TrATrGGT
Y
INFORMATION FOR SEQ ID NO:312: SEQUENCE
CHARACTERISTICS:
LENGTH: 519 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori.
(ix) FEATURE: NAME/KEY: misc-feature LOCATION 1 .519 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:312 120
ISO
201 POUS 9 6I/O91 a2a IPE1-VU:) 180E C 19 96 GTGTTT1TAG
AGCGTGGGTA
GGGCTATI'GA
AACccTTG
TTACTGGAGC
AACACCAACG
TTAGACAATC
GCTAATATCA
AAAGAATAC
'rrcAATCGTG
AAATCCCTAG
AAATCATCGC
AAAAAGT1GG
GCTTTCATAA
AGCGAGACAT
CTAAGAACGC
ATAAAGACAG
AAGAGCATGC
GGC TrGAGC
CGGATCTAAA
GCATI'ACGGG
CGTTTATcAA 'PrrAATAGAT
TGTTAAAATC
TCAAAAAAAA
AAACCCTAAC
CCTTrI'TGAA T1'GAAAATAG GATCCCTTI G
TTAGAATTTG
AGcTTTGATI'
TGTAACCTCT
A'T~cAAAAAG
GAGTTGCTT
GAATCAAGCG
GCGTTCAAC
ACAGCCTGTT
CGTI'AAGGCG
A?1TTGAAAGC
TAGAGGTT
CTATI'ATAAG
TCAAAGCCTT
TTAGCGCT
GGTrCA TrCTCITIT T1WGAGT17
GGXTAAAA
AGAAAAGT
AAGTGTGI'A
AA?.ACGCTTr
CAAACGATA
GAGTCTTTTlC 120 180 240 300 360 420 480 519 INFORMATION FOR SEQ ID NO:313: SEQUENCE
CHARACTERISTICS:
LENGTH: 777 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .777 (xi) SEQUENCE DESCRIPTION: SEQ ID, NO:313
ATGAGTCTTG
CGCTTCCCTA
GTTGCAAGCG
GACACTI1M7 AATrAAAA
TTTAACATGG
ATCGCTTTAG
ATCAATATGG
GATT TITCA CCGTGGCGT1'
TTITGGCTCG
GAAATGGCTA
AGGGATTATT
CTCCAAGCGT
ATI'ATTCTAA
CTrATTTTGC
CCCACCTTCC
TTGATCTTT1' GcTTT1TTGGT
AGTTTTGAA
TGTTTAGA
AAGAGCACTA
CTGTCAGTTC
CCAACC irr'
AAGACCAACA
TTTATTITTAG
TATGGCGGGC
AATCATTTCC
GCTGGATAAT
-1rAAGCC GCGcTTTAGC
GGCGAATTTA
AACTAGGGGA
GCGTATTTTA
CCCTAAAAGT
'TTGAACGGG
TTGCACCCCT
AATGCAATCT
GATAAAAAAT
TTCTTGTTTIV
ATAGATGTGG
GAACCCACTA
TTTTGTGAT'
CAAAACGAAT
GATTTATGGC
AAGGATCT
GAATI'GCCTA
ATCATCATGC
CGTITGATTT
TTrAAAAACG TrAAAACCC
ATTGAAAA
GTGCCGGCTC
ATACGGTG'T
AATTGCTTGG
T'PTGCGAACG
TAAAACGCAT
GCGAAAATGG
TCTACCCTGA
TTCATTATAA
TCCATITCAT
GCTATGAAGC
ATl'TTIAA
ACATCCGATC
AAGTTTTCGA
TTGCTCGCTT
'TTTAGGCGAT
CATGGTGAGA
CACATGCAAG
CCATCAGGGC
GTTTGAAAAA
GCAGTGTTTA
TTGCTATTCT
CAAATACAAG
TGAAGCGAGT
AGAACGCCTT
AAAAACGAT
ACTCTCT
120 180 240 300 360 420 480 540 600 660 720 777 INFORMATION FOR SEQ ID 140:314: SEQUENCE CHARACTERISTICS: LENGTH: 582 base pairs TYPE: nucleic acid STRANDEDNESS; double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
ORIGINAL SOURCE: ORGANISM: Helicobacter pylori AlkArAIMPM 0%24 POUS 961091Z IPEAPJS 18 OEC 1996 (ix) FEATURE:fetr NAME/KEY: nmsc-fatr LOCATION .582 (xi)l SEQUENCE DESCRIPTION: SEQ ID NO:314
GTGATI'GTT
GCGTCAT
TrCCGcAAT
AKTGTGAGT
AGTTTTIAAGA
ATCAAAACCG
TCAGGCTCGC
CAAAAAAATA
GTCTTTTCTA
ATFI'TGCACC
GCAGCGCGGC
TGGGCATGGC
TAAA.AAACCT
TCTTCATGGA
CTITTATCAT
ACCAGCTCTT
TCTTAAATAT
TGTTAGCAAC
AAA.AGAGCCA
GGGGTTGAGC
GATTTICTAAA
CTTTIGGCC
GA[ATCTIT
TTATGCGCTA
GGCGCAAATr TAATI GCAA
TGCTCAAAAT
CCCTrTTAT'
AGAAAACGAG
CATTTI'TTG
TCGCGCTATA
CT T1TTTTCA
GTCGTCATCT
TrGCGTTr
GGGGAGTITT
GAAAAAAAAG
GACATCCACC
TTAAAATACC
ccGGCTAAAA GGTrTCTAT
AAATCAATGT
TI'ACGATAGG
ITTTACTCAT
TrAGAGACGC
CTI'TCGTGAT
GGATTCTTGG
AGCTCCTAT
TAGAATCTAT
AA
GTCTTTGGGG
CCAAGAAGAA
GATGCAGATT
TTTAGTGAT G
TAAAACCGCC
CTI TTAAAT
TITTTTACAC
TCTCATGGTG,
CGCTCAATT
120 180 240 300 360 420 480 540 582 INFORMATION FOR SEQ ID NO:315: SEQUENCE
CHARACTERISTICS:
LENGTH: 396 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc..feature LOCATION 1 .396 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:315 ATGTTCTATC
TTATCAATAC
TrATTAAATr CTCTrrAACAC ATIAACATCG
CTTTATAGA
GTTGAAGATT
TCACGCTAGC
CTI'TTIATA
ACACCCCTAA
CTTTCTITAA
AAAATGATGG
GTTITTAGGCA
TGGGTGTT
AGGAGTGCCT
ACTGGAATTA
AAATAAAGAG
TTGCGGGACA
AAAAGCCACT
AAIT1'TTAT
TAAAAATGGG
CATTTAGTGG
AGGGCTI'IAA
ACGATTT Tr
GGCATGGCAG
CTCATCCCTA
AAAGGAGTCG
TGT
T
rrr GA TTGTGAA
GGCATGAATT
TACAAACTTA
CGGTTTI'TAT
AAAGCAACGA
CGCGTTATAT
AAATAAAGGG
TAACGCTAAT
TGAGAGAGGG
CGCCGCGCGC
ATTTTTIAGAG
CGGCATGAGC
120 180 240 300 360 396 INFORMATION FOR SEQ ID NO:316: SEQUENCE
CHARACTERISTICS:
LENGTH: 639 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
f 1- Pci/U 96IO912.2 IPENIJS 180E C 1996 285 (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION .639 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:316
ATGATIAAAG
'rrGCGCATTA
ACGCTTYTAA
GAACACCAAG,
GTGGGCATCG
CAAGTCGCTI'
ATAGCCCACA
AGCATCGCCA
AATITAGACA
AACGAAGGGG
GTCTATCGCC
CGATIT3ATAT
AACCCAAAGA
GCCATIWIGGC
ATATI'TATGC
'rrITrCAATC
CAATCCTAGC
CCCTAAAACA
GAGTGCTTI'C
CCACTAGCGC
CGTIAGTCT
TAGAAAAAGA
TTCTCATGST
AAGCYTGGYG
CACCATGCTA
CCTAAATTCC
GCATI'ACCTr
CAAGCAAGAA
AGGCGTGGGC
TAAAAAACCC
TAATCAAGTC
AGCCACGCAT
ATcTTTGAT
TTGAAAARC
ATFFT
t
AGGCG
AAACCGGATA
AAA).AGCTT
TTTAAGGGTT
ATAAATCAT
GAATTGAGCG
CAAATCATTA
ATCAGCATGC
GATGAGCATT
AAGGAAAAA
CTCTITRTRA
TGAGCGGGAG
GCGGAACAGT
TGGAATrGCG TrAGCGCTTIT
CCCTTITAGA
GCGGCCAGCA
TCGCTGATGA
TGCAAAATI'A
TAGCCI'CAC
TGGCGTGAAT
CGGTAAAAGC
CAG TI!GTI'A GCGC~rAAAA.
AGAAAACTI'G
ACAATTAGGC
ACAACGCTTA
ACCCACCGGG
CATTACAGAA
TI'GCTCTCAA
120 180 240 300 360 420 480 540 600 639 INFORMATION FOR SEQ ID NO:317: SEQUENCE
CHARACTERISTICS:
LENGTH: 228 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE: NO (vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .228 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:317 ATGCTI'GATA AACGCATrAA AACGCTTTTA C IITTTlTG GTCTTAATAT
GGTGTGTI'G
AGCGTGAGfl TTACCAATAA GCCTCATTTG TGTTIGGT TI TAGTGTT AGGTTGTI'AT ITAGTATG AGTGGCAAAA GAAACAAAAA AAAGAIWITTC AAAGCGCTAA
AAG'ITTGAAA
T1TTGACAGCG. TTAGCGAAT1' AGAAAAGGAT TTTGAACATG
GAAGTAAC
INFORMATION FOR SEQ ID NO:318: SEQUENCE CHARACTERISTICS: LENGTH: 207 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE: NO POUS 96/0912.2 IpEA/US 18 DEC 1996 286 (vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc..feature LOCATION 1 .207 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:318 ATGAAAACAA TTAAATGG TAVI'ATG;ATC GGCACACTCG GTG~CGTTrF TGTTCTAGCT TI'GATGCTCA GCGTTT1CGCT TGTCTCCCTA
AAGACCATTC
GCTTCTACCA AAAAAGAAGC GCAATACATI' CCTAAGGGCT IrT1WrGACCC AACTTAAACC ATTGGGATTC
TACATTC
INFORMATION FOR SEQ ID NO:31 9 Wi SEQUENCE
CHARACTERISTICS:
LENGTH: 570 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc_feature LOCATION I. .570 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:319
ATTGAGCGGT
TI'CAAAAGAC
TArrCTTCT
ATGGAGCTITA
ATrAAGTTI'G
AGGGAGTI'G
AATAATTGCG
AAAGCTAAAA
GAGGTTAA
TTTAGAGCGC
TTATGGCAAG
AGCTCAAGCA
CTAAAATTAG
TTTTAGGCTC
AACAAAAAGC
TCTATTTGGC
CTATCGTGGT
ACAAGCGAGA
CTTGCTCTGC
GTTTAAAGGC
GAAGTGCGGG,
AGAATTTAAG
GGGTTAAACT
TCAATCCAGC
GCTCTATT7
GTGCAAGGGG
GGCTGATAGC
AGCCCTI'GAA
ATTGATTTCT
GTT-TGATTGC
CTGTGTGCGT
CGTGGGGTITG
GATGAAGAAA
AAATTAGAAA
GTGGTGAGCG
rJTTT~TAAAAC!
CCTGTGTTGG
AGCGAAATAG
TTAGAGGACT
GGGCTGAATG
GCCTAAAAAC
AAGCTAAAGA
TGGGTAATCG
GCCAAAATGG
AATGGCTGGA
AAAAATNITI7r
TTCATAAGCC
TGGAAGGCTIT
AGAGCATGGG
CACAGACCCT
GrrrACTTGCG
CATGCAACGA
CAATGAAATA
TCTATCGGTT
AGAGAGCGGT
TTATATTAAA
GTTAGGGGCA
120 180 240 300 360 420 480 540 570
TTCATTATTA
INFORMATION FOR SEQ ID NO:32O: SEQUENCE
CHARACTERISTICS:
LENGTH: 405 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL SOURCE: PCIUS 9 6/ 091.Za lj.L, j 3u- '1996 287 ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .405 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:320
ATGCTTATT
GATGCTATTC
TGGAAT'AG
CACAAGATAG
TTTAAGGATA
AGCAAAATCT
AATCAAATAG
TAGGACACCC
ATTCCAGCGC
CCCAATAT'G
AGACGGACAC
'rrAAGCAAGC TGTTrCTAT
ATGGTGTCAT
TTTAATCCCT
CAATAACGAT
cTGTGAAAAT C'rTTITA
CATACTCGCC
GGA'TTrTAAC rrrCTAAAGAT
AGCGCTCGT
ATAGTGTGTIT
GGCGTCCATI'
TTCAACGCT
CAACAACACG
GATACAGAGT
TCACTCCTI'
'1rGTTTrCAT T1'GAAGCAAA rTAGCGTGAT
TCAAACCGCT
CCACTAATTA
CATGGGAGAT
TGAAA
TAAAAACACC
CCCAAAAAAT
CTTTATCG
CTATI'GTATI'
CTTIGTTAGAT
TTGCGCTAAA
INFORMATION FOR SEQ ID NO:321: (.SEQUENCE
CHARACTERISTICS:
LENGTH: 765 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .765 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:321
ATGAAAAAAA
AAAATCTTAC
AAAAAAGCGG
GA'ITTAGAAA
GTGGAAGCGC
GCCAATAAAG
CCCATAGGCT
GGCTTGAGCG
A
t rTIAAGCC
CATTTAGGCT
AAATTATTGA
ATTGAAGGCA
AGCATCAAAC
GATTGAATAT
AAGAAAATCA
TGGTGCGAGA
GCGTGATAGA
CTTATCTT
CCATGTI'AGC
TrGAAGCGAG
CTAATCACAT
AGATGTTTAA
ATGCGGAATIT
T'ITTAGCGTC
TrGAAAAGAT
TTTTAGGCAT
AGGGCT'TGTG,
AGAAATCAT
CGTGAAAA
AGATAAAGGG
AGCTAAAAAA
GTACCACCGC
CGTGTGTGG
CCrTTrrr
AAATCAAGCG
GAACCCTGAA
TI'TAGCGTAT
AGAGCCAGAT
CGCTAAAAAA
GGTTTAGGGT
AAAGACAGAG,
CACAAGGGCT
ATTGATAT'rG
ACTTTAGCCA
TATGAAMTAG
GGTATCCCCA
AAAGGGATTI!
AGCTII'AAGG,
fTTITGACATTA
GGCATI'GATG
GACATGGAAT
CACCAGGGAT
GCGTGGGGAG
CCGGCGTGGA
ATGCTTTTGA
TCGTGGAGCT
AACAAAARGC
AACAAATCGC
TTATCAAGGC
TAAACGGCAC
ACGCTI'TGAA
AGGGCATTGA
cGAAATI'AGA 'rGCAAAAGA
TGCAT
CACGGTCOCT
AATTAAAATr
AATCAGTGAT
TATGGGTGGG
CTTCGTTACA
TAAAAACACC
TITAAAAGAC
GAGCAATTAC
AGACGCGCAG
TGcGGCGCAC
AGAAATCTI'G
GTTTGGTTAT
120 180 240 300 360 420 480 540 600 660 720 765 INFORMATION FOR SEQ ID NO:322: SEQUENCE CHARACTERISTICS: LENGTH: 729 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) PiSs9 6/ 0 9 IPEUS1B DEC1 288 (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .729 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:322 ATGCAAGAAA AACGACTI!AA GAAAGCGGCT TTATAGATGC AAACTCATGC TCGCTTTG'rr AATTITGTGTG CGATTGTGGA GACAAGGCGA CCATGCGCCG GCCGTGATGC
TI'GGGGATGT
GAATCCATCG
CTCAAGCCCT
GACGTGT1'TG
TGGGGGAATIG
GACAAGACCG CCCATTTCAT GACGCCAAAA TGTATGCGGA GAT'ITGTTAG
ACATCACTCA
AAAGAGGGCA AGACCACTCT
CAGGGCITTT
AGCCATTCAA
ATTGT TTTCT
AGACGAAAAA
AATGATACAG
AAAGCTCCCT
GTTTTAT1'CT
CTCTAATGCG
T'rrTAATAGC
AGAAGCGAGC
TITTGGGTTG
AGACGCCAAC
ACCCTACTI'G
AACAAAATCG
AAGATI'GGCC
ACAGACGCTA
ACCGCTI'CTT
AGCATI!AACG
AAAGCCTTI'
GTI'TTAAGGC
GACAAACAAA
TTAAAAAGCA
CATITTTGGCA
ACTCTAGGTA
CTITTATATG
CTTCTTGGAT
CTTCAAAGAT
TTTTAT'rAGA
TATI'GCATGA
CTCT1TITIGG rrGAGTrGTC
TCTCTAGGGG
AATACTGGCG
TGGCGATTCT
TGGCGTTTCA
AGCCCAATTT
AAAAATTGAA
CAAGGAAAT'
GCTGCGCTCC
TAAAGCGCTC
TGATGTGATT
GAATITTTAAC
TAAAATGGGC
CGAGATI'GAA
TATITTAGAA
TTTAAATAAA.
AATCATTGAT
TAGCGATr'rT
TCAGCATGAA
120 180 240 300 360 420 480 540 600 660 720 729 INFORMATION FOR SEQ ID NO:323: SEQUENCE
CHARACTERISTICS:
LENGTH: 756 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .756 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:323 ATGT1TAGGGA
GCCCTTGATA
CTCTCTATGG
AAAACAGATA
CGCTCCGATG
ITTTGTCTCAT
ATGCAGTAT1T
AGACAATTCG
AAAGTCAAAA
GATACAATGG
GCTAGAGGTA
GACAITCAAA
4,AAAGAAGTGG
AAAAAAACGA
GATTGGCAAA.
TGCTCAATGT
TATTTGTTTA
CTAGGCAAAT
TGCTGTTTGG
GCGATGTGAG
TAGATAAAGT
ATAGTCCCTI
AAAATTATGA
ACTCTTCTCA
TCACGGA'T1
AATCAAAAAA
AGAAGTCT'G
ACTCAATAG
CGCCGCTGTA
TGGCATTGAT
CGTCAATI'CT
TTATAGCAAA
TTTCCAAACC
CCGAGCAGAA
AACGAGATTA
ATATATCACT
AGAAAATCT
ACAAAACGAA
ATI'GATGAAA
GCCAATAGGA
ACGAGTATTG
CGATACACAG
GAAGCCGTTG
AATTCTI'TGA
CAAGCAATGA
GCTATCATTA
ACAITTTTTCA
AAAA.AACAAG
ATCATCAACC
CAGACAGTAA
ATTTGGTTGG
CTI'TCAAAAG
TGATGATGAT
GAGAATTTAA
TGGATAGTGC
GGGATCGCAA
GAATGTICAA
GCTCCAACAT
TI'ACCATCAA
TAACTATTTA
CTTTTGGCTT
GCGAAATTTT
GGGTGTGATA
GGCTTTTTAT
GCCTTTGAAG
AATCGTCAAA
AAcT1TCAAAA.
GGATCAACTA
TGAAAATATC
ACAAAGAGAA
AATCACGCCT
TTATGATT
CAAAGTGTT
GAGAAAGATI'
120 180 240 300 360 420 480 540 600 660 720 756 TAAGGCATTA AATAAA PCTIS 9 61/0912.a IPEA!US 1 8 DEC 1996 289 INFORMATION FOR SEQ ID NO:324: SEQUENCE
CHARACTERISTICS:
LENGTH: 495 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE: No (vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION I1.. .495 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:324 ATGAGAGCGA
TCGCTATTGT
ATGAITGATT TTTrCAATAA AAGCTCTTTG
AAAAAGTGTT
AATTATGGGG
CGAGTTT
ACTTTAGAAG
TGATGGCCTA
TGTTGTITGT
ATGGCGITITC
ACTI'AAAAC
AAAATCAAAA
CCTATCGTTC tTrTAGCCTT CGCGCACGCA
AGATC
TTTAGCCAGA
ACCCATGCTC
TATCTCTAGC
GAATTTACGC
TCACATGAAA
AGTAT1'TTA
TACGGATTAT
GAAAACGGCG
AGTTCCAGTA
GCTTACCCTA
GATAGCATGG
CCTAAAAATT
GAAT1'AGAAT
CAAGAAAAGC
GTTTTCACAT
TTCAAATGGC
AAI4GGATI'AA
TTGAAACAGC
AGTATGTCAA
TAGCAGACGA
TAAAAGATGA
ATITTACAAAA
GCTCTCCCT
T TI'AAAGAG
GAATAAAAAT
ACTAAATTCC
TTTAGCCAAA
CAGGGCCACG
AGACATTGCG
CGCTTTrTGAA.
TAGCGC'I"ICG,
cATTcAAAcA 120 180 240 300 360 420 480 495 INFORMATION FOR SEQ ID NO:325: SEQUENCE
CHARACTERISTICS:
LENGTH: 513 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(Vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 513 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:325
ATGAGTAATC
T?1'GATAATA
AAATCCAACA
GTATTTGATG
AAAAATATCT
GAACCCGGGC
,\GsSGCGGAAG
AAGCGAGCCA
AGGGGAATAC
TTAGCGCTAA
CGRATATTGG
TGCATGYCT1' ?1'TGCTTAAT YTrCGATI'C
TTTGGATAAT
CAAATTCATC
TTTAGCTTAC
TTAGCGAAT
AAAAGGCGAA
CCCTGGGGAT
ATTCTAGAT
TTTATGAACG
GCTATCACAA
TCTI'TATACA
TTAGATGTCA
GycAAATTGY
AGCGGCGAAG
GAAGAGGGGG
CTAAA-AATCC
GCGGTAAGGG
AGAAAGGTTA
TTTTGGGGT
AAGAAATCAT
AAATTTTAAA
TTCTAAGCGC
CAAAAGTTTT
GGGCGTGGGG
TAAGGTAGGG
GAAAACCCAY
TTGCGAGAITT
ATACATCAGC
TTAATTTAT
120 180 240 300 360 420 POT/US 96/09122 290, Ep J 8D C 1996 ATTTTAATTA ATACATrC TAAAA.A'rTG GGTCCACTAT CTCAAAC TT TCTTAATTTT 480 CAGTCAI'1M TT TATI'?I TAT1'CAATCT CCC 513 INFORMATION FOR SEQ ID NO:326: SEQUENCE
CHARACTERISTICS:
LENGTH: 186 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc...feature LOCATION .186 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:326 ATGCAGCATT TAGTCTTAAT CGGTTI'TATG GGGAGCGGTA AAAGCTCTCT AGCACAAGAA TTGGGGCTGG CTr1'GAAATT AGAAGTGCTG GATACGGATA TGATCATrAG, CGAGAGGGTG 120 GGCTTGAGCG TGAGAGGGAT TTTTGAAGAG CTTGGCGAAG ACAATTTCAG GATGTTTGAA 180 AAAATT 186 INFORMATION FOR SEQ ID NO:327: SEQUENCE
CHARACTERISTICS:
LENGTH: 654 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .654 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:327
ATGAGCATI'A
TTAGAAGGAG
ATCGTGGTGG
CAAACGAGAG
GCCTTGCAAA.
AGAGCGAGTG
AGGAAAATIT
CGTTITAGATT
CTTTTATCGC
AGCGGATCAC
AAAGATITGAA
AGAGGAACGA
CGTI'CGCCAA
CCATTC?1'AA
AAGACGCAAT
AGAGcAAGT
AGAAAAGT
TTATTI'AGGG
TCAANITTTAT
AGAAGTCGCC
TGCAAACGAG
ATATI'CTIAC
AGAAATGAGC
CAAAAAAGCG
AGAAACGAAT
TTCAAA.CGCT
GATACAAAAT
AATGA.AGTGC!
CCAGAGTTGT
TTTA).AAGGC
GCATCGCTCT
GCTTTACAAG
CATCAAAGIT
TTAAAAGCGA
ACAAGTGGGT
TACAAGAT'A
TAGAGAGTCC
ATGACTTGTA
TTTCGCAATC
CTAGAGATAA
AAGTGAACTT
TATcAACTAT
TGAAAAGCTT
GTTGTTGTTT
TAAGCATGAG
TAATAATATA
TCAGTTCGCC
rTCTAATGAA
AAACCTGCTT
GTTGTATGAA
cCCTCTAAGT 120 180 240 300 360 420 480 540 PCIUS 90I91? ~1U 1996 TCTI'CACTCT ATG-CTATAAT CTCTGTTTTA AAACAT1'ATG
GAATGTTAGA
cAAAAcccTT CCAAACCAAC CAATCTAAAG AAAGAAACCA TrCAAGGAAC INFORMATION FOR SEQ ID NO:328: SEQUENCE
CHARACTERISTICS:
LENGTH: 303 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1 .303 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:328 AGATA LTCAG
GCAT
GTGCATTTCA
ATCAGGTGT
GGGCCCGGGA
GCGCTTTAAG
GCCATAGAGC
AAGAAAGCTC
GCGATGGGTG
GGGGGAGAAT
GATTTATI'CG
GCGAGCAAGC
GTT
TCTCCCAAAA
AGAAGAATAC
AATTCATAAC
GGGGGTTTTA
GGTCTTGTGC
GGCGTGGGCG
CTTAAAAATA
GcTAAAGCGG
GAAACGAGTT
GGGGGGTTAG
GGGGT1'TATA
TGGCTTTAAG
TrAAAGAAGA
AAGTCGATCG
CGCACCAAAA
CCATCTAATC
CTATGCTAAA
ATGCGAGAGC
TAAGAATGGG
INFORMATION FOR SEQ ID NO:329: SEQUENCE
CHARACTERISTICS:
LENGTH: 240 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .240 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:329 ATGAAAAAAT TTrTTTCTCA ATCTTTGTTA
GCTCTTATTA
GGCATGGATG GTAATGGCGT TTTTTTAGGG
GCGGGTI'ATT
CATGCGGATA rrAArrCTCA AAAACAAGCC
ACCAACGCTA
CTCTI'GGGGT ATCAATTIT' CTITGAAAAA
CACTIGGCT
TCTCTATGAA TGCGGTATCT TGCAAGGACA
GGCGCAAATG
CGATCAAAGG
CTTTGACGCG
TACGCCTTTA
TGGGGTTT
120 180 240 INFORMATION FOR SEQ ID NO:330: POT/US 9 6/ 0912? a ,pE~jUS 8 DEC 1996 292 SEQUENCE
CHARACTERISTICS:
LENGTH: 1341 base pairs TYPE: nucleic acid STRA.NOEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1 .1341 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:330
ATGCTAAAAA
GCCGT'CTI'G
TATCGCCCCA
TATGATAAGG
AGCCTTCTAG
GTCATGCGCG
CTAACCCAAC
CTCAAAGAAG
GAGCGTAIT
TrAGGGTATT
GCCTTACCTA
AGGGCTAATG
AAATCCGCTC
CCCTATGTCG
GGCTATACCA
CGTrGGGC
TCTAATGATA
GGTAAGATT
ACGCAAGCCA
GATAATGGCT
AATTATAGTA
TTTrIAGGGC AATrI!AGCGA k.GATTITA
TGGTITATC
TrGCTCAAGT
TTIGGGTAACT
GTGTCGCI'C
ACAGATTTTIA
AATCGTTT
TTATGCGCGT
CGGTAGAAGA
CACCCTCTT
CTATGATI'AA
AAACGCTA.AA
AACTCGTIAA
AAACATGGTG
CTATCATCTC
CATACGCATT
TGAACCAC nTITITIrGG- TTAAAAAACC
CCTITGACAAA
GGGCTCCAAG TTrATGAC ATATI'TTAAG
GCGGTTGTAT
TCAATGAAGT
GCCAATCGTC
TGGATGAAGT
GTTGAAGCAA
TAAAACTCAC
GATAGATTG
ATCAAAAAAT
CTTAGAAAAA
AAGATGAAGA
CAACTTAAAC
TAGCCTTAGT
GGGGGGGATT
AACGGCAGT
TGGGAGCGCR
ATTCCACCAC
TTCCAAAATC
AAAACAGCGT
GCAAAACCAC
TTGTAACCrrr
GCAAGAAGCC
TCGCTTIGGCT
A
GTTTTrATTT
ACGGATAAGG
GACAGAAAAG
'TTTGAAGAAA
TTI'GAGCATG
AGTGGTCGIT
CTCACACGGG
GAAAAAGTCT
CATGGGTATT
CTCACGCTTA
CCTACCAAAA
TCTTTIAGGCY
TATAACCAA
'rrGGATCAAT
GATTACCAAC
ATCGCTAAAG
GCCAGCATGA
*GATTIATAAAA
*ATCAAGCCTT
CCTGATACCG
GCATGGCACC
TTGAGCCATI
TGATTATCGT
ATATI!GCTAA
GGCGTITGiAT
TCCCCCCACG
GGGGGATCAA
ACACTGAAGG
A AAAAACCCT
TAAGCAAAGA
ATGGCGTGAA
AAGAAATCAC
ATITAGAATI'
GGATITCTTC
CT'TCCACGCA
TAGACGGGTT
GCTTAGCGTT
AGAAGCCAAA
TAGTTACAGA
AAAGCGCTTT
TTGTGTATCA
CGCGAAATT
CTAGCAATTA
CGTI'AAATCT
AGGGTITGIG
AATTAAAGAT
CGCTAATATT
ATTTGTTGAA
Tr1TAGACGCT
GGGTAGCACT
AACCAGAAAA
AGAAATTTTA
AACCGCAAGT
CATGTTAGTC
TTCACTCTCT
TAACGAGCTC
AAATATCGCT
AAAAACTCAA
GGAGTCTTITG
AACTAACGCT
AACGAGCACC
CAATCGCGCC
AATCGCTIT1T
TGAAAATGGC
TRCTCGCAAA
GGCTACGATT
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1140 1200 1260 1320 1341 INFORMATION FOR SEQ ID NO:331: SEQUENCE
CHARACTERISTICS:
LENGTH: 654 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE: No (vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: KOLB 9 6 0 9 2.
i8UDEC j~ NAME/KEY: misc..feature LOCATION .654 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:33-
ATGAACGATA
TCACAGAGCA
GAACAAAGAT
ATAGAAAAGC
CAGAGAATAA
CTG~rAGGAT
AGAACTAGCA
TITTACTATG
ATTTATGAAC
AAAAACATT
ATAAAAAATT
CAACAGAGCA
ACGATCTCTI
'rrCACGAAGC
TACCGCAAGA
TGGAAGCATA
TGTGTATGG
AAAACACAGA
CCTI'IGGTGT
TATATATCTT
GCTI'CATAGG
TTATCAATGG
CCATGGATCC
AAATTTGCTA
TTAAAGAAT
AAAAAGGTAT
CGCTCATTCA
TGGGATATIT
GCTAGTGGAA
GGGTGCGGT1'
AGGAATTGGT
TATGGGCTAT
TCTT1'TCGCT
AATCCGCTAA
GACTCGITAT
CAAGAAGAGT
GAACTICTGA
TrCTTAGGAT GTITTGTIwIG
AGTCTAAAAA
TrTrTTTTG
AGCACTAACG
TTGA TATA
TCAAAGAAAC
ACGCCCACC
ATCCTAAAGG
TGAAAAATAT
TGCAGATAGG
ATATAGGGGG
CAATCTATIT
CAAAATTAAA
GATTAGAAAC
ACAAGGTGCT
AAGTTATTAA
AAGGCGGTGC
ACCTAGCAAC
GAGTITAGGG
CCTAATAGAA
ACAAGCCAAA
ACTAGAGOAT
TGTATITrA
ACTTCAGTAT
AATTAGATCG
AGTlTATl'GGT
AGAA
120 180 240 300 360 420 480 540 600 654 INFORMATION FOR SEQ ID NO:332: SEQUENCE
CHARACTERISTICS:
LENGTH: 576 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (geflomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
A vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori
FEATURE:
NAME/KEY: misc-feature LOCATION I. .576 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:332
ATGATGGATA
GAT4GGGCGTT GACAcTTTGA GGGCATTTrA CT1'GT'rrTTG
CAAACGCCAG
GCCATGCCTT
GCGAGTTTAA
AAAGCGTTCC
TTAGAACGCC
AGGTGGGTTT
TGAACGCGTA
TCTCTAAAGT
AAAATAAGGA
CTTrTGATCGC
CGAGTTTGAT
TGATTGGGTT
GCTCTAAAGA
CCTATI'CGCA
TAAAAGCT
TAAATCTCAA
TTTTGGAGGC
TGGGACAGAA
TTTGTTGAAA
TCATTTGCCG
CACGATTCTA
TTTAGCCGC
GACTThGCC CCcrTrrAT
TTGGGTAAAA
SGGCT TTTAG
AATTTAGGGA
CCGTTGGTTT
cTcTI'GT'rl'
AAGAACGAAT
AAAGCGTrAG GT1WITCTI
GC
TGATGGACGC
ACAAGCGGGT
CCAT1'ITAGG
TTATGGGAGG
TTGAAGGCTr
TGCCGGTGTT
ACAATGCGGA
TGTcCATGT
ATTTCACGCA
TAGCAAGAGG
GGTGTTGTTT
GCATGAGTTA
CTTGCTCGCT
TAATGTCTCG
TTCCTTTTAC
CAAGT1'TGGG
GAATGAAAAT
CCCGCCGCTA
120 180 240 300 360 420 480 540 576 GGATTATGAA ATTGAA INFORMATION FOR SEQ ID NO:333: SEQUENCE
CHARACTERISTICS:
LENGTH: 603 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
NOT/tiS 96/091 2a IPENS 18 DE C1996 294 (iv) ANTI-SENSE: NO (vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori yEATURE: NAME/KEY: misc_feature LOCATION .603 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:333 ATGAATAmT
AAGCTCAAAG
AA'TTCAACC
TCAAGCTI!AG
TTTGGCTIGG
TTGGTGGTCA
TCCACTGAGA
ATGATTIGCTT
TTAAAACTT
CATCACGC
TCA
ATCAAAAAAA.
CCATI'AAAGA
TCTTAGATAA
AGCTATATAA
GTAATGGGGT
TTGAGCCTGA
TTrAGAAAA CATTATT'rGA
TTAACGCTTA
GCGCTTTAGA
CTTGCAAGCT
AAACAAAAAA
AGAAACAAAC
AAATAGCGA.A
GT1TTATCGC
AATAGAGGTG
TCGTTI'GATT
TATGGATAAA
TTATGAACGA
GCATGGCGCT
CTITTCAAAA
TACGAAGTGT
ACGCCcTrAT
ATITCACATGC
TI'GCTITTAG,
ATITCATTG
TTAT1'GCATG
AAGTCTCGTT
TACTCTCATC
ATTAGCGTAG
AAGACCCTCT
TTI'TAGGGAA
TTGAAAAAAG
TCTATCCTTA
GCAATGAAAA
TCTGAATCT
CAAGTTwTTTG
TATACGCAAG
AAATGATAGA
GCAATGACGC
TTTGTTCGCA
TGATAGCGCG
CCCGCTAGAT
TTTGTAT TAT TTrAAAACGC TrGGATlTr
CA!TACAAC
AATGTATGAT
AATCAACCAG
TAAAGCGCAC
120 180 240 300 360 420 480 540 600 603 INFORMATION FOR SEQ ID NO:334: SEQUENCE CHARACTERISTICS: LENGTH: 390 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .390 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:334
ATGAAAAAGA
CCTAAGTGGT
AGTGGTTCAG
TCTATI'AGCG
?I!AAAATCCA
GTAGAAATTG
TCAAAACTI'G
TTATI'CTTGC
ATAGCAAGGC
CCACT1'CTAA
TGGTGGTCAA
GCGATrCACA
TCAATCAAGA
TTTTTGCAGG,
ATGCCTIGTG
CTATAACAAA
AGAGGCTTCT
'rrCACAA.ATC
AACGATCAAC
AGCGCAAAAA
GITI!AAGGGA
GCITITTGTGG
ACAAACGCCC
AAACAAAAAG
CACATTCAAA
TI'AAAAACCG
GGGATCTACT
GTGCCAATTTI
AAAAAGGCTA
CGTTAGCGGA
AAAGTCGTGT
ATGACTTGGA
ACACCAGAGT
AAGCGCAGAG
TCTTTATGGG;
'TrTAGTGGCG
GGATAATAAG
A?1TGAATAAT
GAGGAATCAA
120 180 240 300 360 390 INFORMATION FOR SEQ ID NO:335: SEQUENCE CHARACTERISTICS: LENGTH: 432 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular S (ii) MOLECULE TYPE: DNA (genomic) PGTIUS 96IO91a2.
IPENUJS 18 DEC 1996- (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .432 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:335 ATGAAAATCC
AAACAATITC
ATTGTTGGCA
AAAITTCACC
ATGATCGCTG TTTrAGACTC TTCACTAACA
GCCCAACAGA
AACGGGCIG
TCAATTCTAA
AATAAA??ITA
AAAACAAAGC
GGGT1'RGSCA
ATGGATATGG
GCTTTAGGAT
CC
AACACTTGTC
CCACAAAACC
CCAATCTITGG
TTGCGATAAT
AGTCGATCAA
RGATCTTGAT
CAATGATGGT
CTrACAATAA
GCAGAAGAAT
GGCGATGCGA
GATCCT'rcAA
AAATATGTGT
GTAATTGTTI'
GAATATGGCA
TAATGGTAAT
TCACYAATrT
TCTTAAACGC
AATGCGTAAA
TAAACAAACA
TAAAGGATTC
cATI'AGGGGT
ACAAAAAA.TG
AATGTTGAAC
TCCTITGAG
TccTGGGACA
AGACATI'GTC
AGGGGTTGTA
AGwAGCCTAT 120 180 24.0 300 360 420 432 INFORMATION FOR SEQ ID NO:33 6 SEQUENCE
CHARACTERISTICS:
LENGTH: 927 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .927 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:336
GTGGTAATAA
TATCTTGTCT
ACGCTGTTAG
AT1TTTGTCT cTCTTATCCA
ATCCTTATCA
ATCACTGI'T
AGCATI'GCTG
GAAATCTCTG,
TI'GCATGACG
AATAGCAATA
GATAITGAAC
AAAAACATGC
ATTAGGGTTT
CGCATCAAAA
TCTATCAACA
GGITAGTCCT
CTGTTAGCGA
T'rrGTATAGG
AAAAGGATGA
TTACTACAAT
TAGGAACGGT
GAGGGATAAT
GCCTAGAGGG
GGCGCTITGGC
ACACTGCGTG
TGGTGCATAA
CCACTTTCAT
GGGCAAAGAT
ACGCCCTGGA
AACAAGACTC
AAACATGCTA
TTTTGTGATT
CCCGCAGGCA
rTTIATTTTT GAT1!1TGGCG
CATCGCGCTC
GGGGATTGCG
CCTTATTATT
CAAAGTAGAA
GGTTTTGCCT
TCGGCGCAT'r
GACTATAAAA
TGGAATCACG
TGAAGACGGG
CGCTAATCGT
TTCTAAG
ACATGTCAAA'
TGCAAGGAAA
AAGCAT'TI'G-
TCGTTTTTCT
AATTTTGTCG
AGCACGCTAG
GTGGCGTTGG
TTACACCCI'
GCGCTATT
AATAGAAGTG
GAATGGGTCT
GATGTTATTG
GATTTTGGAC
ATCTTI'AATG
ATGAAATCC
TTAGCTATAT
GATTTATGGA
GGATAATCTI'
TACGGAACAA
CGCAGGTTAC
GCGTCCAAAC
CTTTAAAAGA
TCAAAAAAGG
TI'r'TAATAC
TCGCTAATI'C
GTGGGGTAGG
ACGGGATGGA
AAAGTTCGCT
TGAGGAGCGA
cTTTCAACAA
%AGGATAAGT
rGAAATTAAA
~ATCAAGGCT
AACCATGAAA
IV1TTATCTTA
CACCTCTATT
TTATCTI'CA
AGACATCATT
TrTTTACGC
TAATATI'ATC
GTATGGGAGC
AAAAATTGAT
GAACTTCACC
ACTCATTGAA
GCTAGATA'TT
120 180 240 300 360 420 480 540 600 660 720 780 840 900 927 IpEIS 18 0L G 996 296 INFORMATION FOR SEQ ID NO:337: SEQUENCE
CHARACTERISTICS:
LENGTH: 491 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .491 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:337
ATGAAAAACT
CTGAGTCTGC
GGCACGGCTT
AACCCGGCTA
ACCACCACCG
TTATATTCGG
AACACTATAG
TTATCACAAG
TrI'CCCCACT
CCTTGCTT'C
TAGGCTCGGC
ACATGGGCT
TGATCAATAT
TAACAAGTITT
GGTTAGGCAA
CTATCAATCG
CTAI'GTCI'
r1'ATGCGAAT
GTATGTCGCT
TACTAACGAT
CCCGACCTTT
AGAAATTGAT
TATCCT1'AAA
TGTI'CAAGGG
AAAARGCTCA AAAAACGCCA
GGGGCTAGGG
TGGGGCGAAA
AGCTTTAAAG
AAAAGCCAAC
GCGCTI'GGCA
CTTATGAACT
GTGCTGACGC
ACAGAAGCGA
TCCCTACGAC
AAAATATITTT
ATACGGCCGC
TAACCAATCA
TTTAATCGCT
AAGCTTGAAT
TTCTTTTTAC
AT1'TGAAATG
CAATCAAGRC
AGGCATCATC
TACCAATGGC
AAAAGTCGTA
120 180 240 300 360 420 480 491 ACCCTCGCT'
C
INFORMATION FOR SEQ ID NO:338: Ci) SEQUENCE
CHARACTERISTICS:
LENGTH: 162 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .162 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:338 ATGTGT'rTAG CGATCCCCTC TAAAGTCATA GCCATI'AACG ATAATGTGGC ACTCTrAGAG ACI'TGGGCG TTCAAAGAGA AGCGAGC TG, GATTI'AATGG GCGAGTCCGT
TAAAGTGGGC
GATTATGTGC TACTACACAT CGGCTATGTG ATGAGTAAAG
AT
INFORMATION FOR SEQ ID NO:339: Ci) SEQUENCE CHARACTERISTICS: POUS 9 6!/O912Z IpEAIUS 180 EC 1996 297 LENGTH: 606 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .606 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:339 ATGAAATATT1
CTAGATATTIA
AACGATGCCA
CAGCATIITG
GATAAAAAAG
TCACGAI'AA
ATTGTAAGTT
TATTI'AAAAG
GGACCAGGAA
ATCAAAAACA
TATTAC
TATGGCTTT
TTAAAACCAT
A?1'ACGCT1T
ATGTITCTCA
TCCATCTTGT
AAcTTTATGA
TAGATCTATA
CCCCTTCTAT
TCACAAACAT
AccGACTCAA
TITAATATAC
TCAAAAACTT
AAAATTGCAT
AAACAAAGAG
AGCGCTTGTG
TGTGGATACA
CCCTTTTGCA
CG CTrGGATG
CGCACTAGCG
TATTTTCCCC
GCTATAGGGC
CCTAAGATTG
GAAGTCTTAG
CAAGGTGCTA
AGCGTGGCGG
GGAACGCTCA
GCGCACAACA
AAGCGCCTGA
AATTATACGA
AAATGGGCGA
TTTr1'GCAAC
AAGTGCGCTA
CGAACGA TT
TCAATTACGC
TAGAAAACGG
AAAAGACTTT
TGGCCATTGT
TTGTITTC
TGcGTTATCA
ACGCTGAGCA
AGATAAAACG
CTCCATAGAT
AAAGACTAGC
AGAACTCAAG
CAATAAAATX
TGACTACCCC
GGTGAATGAT
TAAATACAT
AAAAGAAATC
AACGGAGTTT
120 180 240 300 360 420 480 540 600 606 INFORMATION FOR SEQ ID NO:340: Ci) SEQUENCE
CHARACTERISTICS:
LENGTH: 615 base pairs TYPE: nucleic acid (C).STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (i x) FEATURE: NAME/KEY: misc-feature LOCATION .615 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:340
GTGGTGAGCG
TTAGAGGGCA
TI'AGTTCTAT
CATAGCGAAA
TT1'GTGCATA
TCTTTATI'CC
TTGAGCGTGG
ATTGAAAGCG
W ACGATGAAT
GGGTGGTGAT
AGATGTY'TAG
CCATCACTAT
CCTTTTTAAC
ACCCTAAAAA
CTTTTGTGGG
AAACCACCCC
CGAI'AAAAA
TGGGGCTGGA
cATTATTGTG
GCCTTTAGCG
cATTCCTGTA
GAGGTTTTTA
AGTGATTTTA
GAAGAATI'TC
CTCTATTTCC
GCATGTCAA
'rTTAGGGGGT TrrI'TTGTGC
CAAAGCAT'G
GTGAGCTCTC
AACAGAATCT
GGAGCGTTTG
AToCCT GCTT
TI'AGATCAAT
GAAGTTAAAA
TTGAATCAAA
CGATTCTAAC
TGTATGCGCT
TTGTCTTAAA
ACGCCCCTT
TTTTTAAT
TAGATGAGGG
CTAAAGATCT
GCATTGTCGC
CCGATACTT
CTTACAGGGG
TTTAGGCACT
AGCCACGCCC
ATTGGAATTT
CGCAAGCCTT
CGATGTGGTT
CATGTTAAAC
GCGCACAGGG
TATTITCTTTC
120 180 240 300 360 420 480 540 PCT/JUS 96/09122 1PEA/US 18 DEC 1996 298 ATCCCTAAAA AAGAATGGAG CGTTAAAACC AAAGATGAAT TGGTTAGAAA AAATCATGGA 600 TTCTTTAAAA GACTT 615 INFORMATION FOR SEQ ID NO:341: SEQUENCE CHARACTERISTICS: LENGTH: 216 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...216 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:341 GTGGGATATA TCCCTARGGA AAAGATTGTA GGCATTAGCG CGATCGCTAA ACTCATTGAA ATTTATAGCA AACGCCTGCA AATCCAAGAA AGGCTGACCA CTCAAATTGC AGAAACTTTT 120 GATGAAATCA TAGAGCCAAG GGGCGTGATC GTGGTTTGTG AAGCCAAGCC ACTTGTGCAT 180 GAGCATGCAA GGGGTGCAAA AGCAAAATGC GATCAT 216 INFORMATION FOR SEQ ID NO:342: SEQUENCE CHARACTERISTICS: LENGTH: 39 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...39 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:342 GTGGCTCTTG TGTTTGATAG TTTGATAGAG AACAAGAAG 39 INFORMATION FOR SEQ ID NO:343: SEQUENCE CHARACTERISTICS: LENGTH: 297 base pairs TYPE: nucleic acid STRANDEDNESS: double tX" ~cv IPENUS 180DECA996 299 TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(jv)-AN'rI-SENSE:
NO
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1 .297 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:343
ATGAAAAAAA
GAAGTGAGCG
ATGAAAATCA
GCAAGAGAGG
TAT1'CTT1'AG TrGGTTTGAG
CTGAAGAGAT
ACCACACGAA
ATITAGAGGT
GGGGCGTGGT
CTTGTGT'rG
TGCGGATAT
GGGGT'TrGC
GCCACTACTC
CGATTGGACG
rrTCTACAAAC
GCTAAAGGCG
AATGAAAAAG
ATAA.AAGCAA
TGGGTTrT
TCAACGCCAA
TGTTCCTCCC
AAATCCCTGC
GOTTAGGGGA
AAAAGCCCAT
AGAGCCTAAA
TAACCCGCAA
GTCTGTA.AGG
ATGGCGT
INFORMATION FOR SEQ ID NO:344: SEQUENCE CHARACTERISTICS: LENGTH: 300 base pairs TYPE: nucleic acid STR.ANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .300 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:344
GTGATCAAAC
GGGTATGAAC
rrrAAATITYCC
AATTTGAGCG
CAAAAAACTT
CTCATAGCGT GOGATTOOTA TGCAGGTACG
CACCCGTAGC
CTGGCACGGT
GGATAATGAT
ATAAAGA'TTT
TAAAGTTCAA
ATAAAGCCGA
ATTTATAGAA
AGGATTGGGA
GGCTTGGCTr
TATAGGGGCG
GTAGGGGATA
TGCGAACAAT
TTrGT 'rGTC
TGAATCATCA
AAATTAAGGT
GGATCGCTCA
TAGATGAAAC
TTTAGAAGTG
GGTGATGGTG
CATITrAGCG
AGGGGTGGTT
CTTCAAGGG
INFORMATION FOR SEQ ID NO:345: Ci) SEQUENCE CHARACTERISTICS: LENGTH: 765 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO
PCT/'-
IPANUS 18 DEC 996 300 (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylor.
(ix) -FEATURE: NAME/KEY: misc-feature LOCATION .765 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:345
ATGGAAATCA
AAAGAATATT
AATGACCCCT
GGCGCGTATA
TTAAGAACGC
GCCAAAGAGC
GAAATCGCCG
ATGCTATTAG
GTGGGGGCGT
CACTITCAATT
CAAACCCACA
TACCATAAAA
ATCGCCCTCG
'ITTTATTAAT
TGAA.AAACCC
A IVITGCTGGT
TGCGTCTT'I
Trr'rTATCCA
TTCTCAATGA
ACCACACOCA
CCTATGCTIGA
TITTGCAGAT
CAATAGAAAT
CCACcATGCA
TGAATGACAA
CTTCCCAACT
TGTTGCGGCG.
CCTAAACCCT
GCAATCTAGC
AA.AATTI'TA
TGAATTGGAG
GCCsGTGGAT
TGGAGAATAC
TGGGATTTTG
AGACAATCAA
CCCTATGTCT
AGATITAGAA
CAAACGCTAC
TTTAGAAAAT
GTTGTGTTGT
AAAACCAAAA
CCCCTAGACA
GACATITCAAA
cAGcccTTAA
AAAAAAGAAA
ACCAAACGCC
GACAGCAAAG
GAITTTAACG
TTAGAAGAAG
AAAAAAGCTT
AGCGAACAAG
GA 'TAAAAG TrTATTTTTA
CCGAAGAATA
AATTCAAGCA
AAAACGCC IT
ACAGCGAACA
ATTTTGAATC
TGAAATI'AGT
AAAAAGAATr
AGCTTTATGA
CAAAAAATCT
TGGATAAG
ATTTATCTC
ACTCA
CAACACCCTC
CGACTTGAAA
AACCCAAATA
GGATAACGCT
GCAAAATITA
CTTATGCCAA
GGAATrrCTr
GTTITTTAGAT
CAATITTGAA
MrTAAATC
CGCCCCCTAT
TTTGAAAAAA
120 180 240 300 360 420 480 540 600 660 720 765 INFORMATION FOR SEQ ID NO:346: SEQUENCE
CHARACTERISTICS:
LENGTH: 318 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix).FEATURE: NAME/KEY: misc-feature LOCATION .318 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:346
ATGGAAGTAG
GTCATTAAAA
TTAATTTCTC
GATTTAGCCA
GTCGTGATCA
TTGAGAAAGA
AGCATGGCAA
TGATGC!TTTT
TAATAGGCTA
TTAGGATTGG
TCGTTAGT
ATAAGTAT
GATTGAAACC
AGAGAGCCTG
TTCGGCTAWG
CTATCAAAGT
GCAAATCATT
ACTTTAAGCT
CCTTC'I'ITAG
GCYGGAGCGT
TATAGGGGCG
CAAAGCGCGG
TGGGGGCGTC
TGAATAATAT
TAGGGGCTGG
ATGTGcT1T-
GGGATTATGT
TCATI'TGGAA
CACCATCACT
GGGATTGGGG
TrATGCGGTG
GGTGAAACGC
120 180 240 300 318 INFORMATION FOR SEQ ID NO:347: SEQUENCE CHARACTERISTICS: LENGTH: 1581 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular PCT'1
IPENS
96/0912 18 OEC 1996 (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) AN'TI-SENSE: NO ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .1581 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:347
ATGAACGAAA
AAAGTI'AAAA
AAAATTGAAA
GGTGAGCCTI
GATGAGGCGA
ATI'GAAACGA
AAAATCACTC
GTTTCAGCCC
GTGGTAAAGA
AAGCAGGTGC
GGCATGTCTT
GAGTATAAAA
AACGCTTTTG
TTTAAACTCG
GGGGCGGTTA
CCGATTGATT
CGTTTTAA.AG
ATTTTTGATG
GCGGAGTATG
CATCATGAGG
GACCCTAAGG
TTTTCGCCCC
TACATGGTIGC
GCCTTACTCA
GTAATACCTC
CGCATCCAAA
GCGACTT
TTGACAAATC CGTI'GATATC CCCCAAAGGG TGGTAT1'GAG ACGCCCTAAA
ITTAGCGACC
ATATI'GTCCA TCCTATITGC TGGTGTGCGC CGCGCTITTG TrGAGCGAGA ATI'GGGCAA AAATCAGGAA
AGAAGAGTTA
TCACTTITAG
AAAGATCCTI'
TI'AGCGACAG GTrGCACAAC GTAI'TCTAA AGAAACTCTA CAATCAAAAA CGAATTAGAA ATATI'AAGGA GTATTTGCAC CGAGCAATT AGAAAAAAAG TTACAAGGGT GAAACGCCCT ATATTGATGA
AATFTTGGAC
GCTACAAGGT TTTAGGGAT ATTACATCGC TIwTGCCCAAA AATCTTCTGT TrATGAAGTG GTAATICAGC CCATTGGAAG GCATGCGGTG GTTGCAAAAT AATTTTACGA ACTCGCTAAG ATGGGGACAC TTACACTITA ATAGTGATTT GGGCGATAAA ATCAAGAAT' AAGGAGTGGG GTI' CATITG GATGGATCAG GAAGAAACCG CFI'GAAAGAA TTTGGGCGCT C GGA C'ITAC
GTTTTAAGGA
AAAAGCCATA
GTGGCGAGCG
CATGATGTGG
GATGTGGCTA
GGCGTGAGT'
ATTAGCGCGA
ATGCTCACCT
GCGGTGTATG
GACAAGAGCT
AAAAACAAAC
CT7rITrGACA
TATTCTATTT
TTGTTAGCCA
ATI'CATGA
GAAAATGGCT
CAGATCCGCA
TATAAAGCCG
TTAAATACC
AACGATTTIGT
CCGGTGGGCG
GCCACGGACG
GATGTGGTI'A
C?1'AAAACTT
AT'TGACACTA
GGAT1'CTGGA'
CTI'TAATI'GA
AGGGGCAATA
TGGTGGCGTT
TAGAAGACAC
ATTI'AGTGGA
CTCAAGATCC
TACAAGATCC
TAGACGCCTT
ccc CCATAGC
TI'TATTATAT
AGTCTACT
GCGGGTTTAG
ATCTTAAGAT
TI'AGGAFITI'
ATTTCAAACC
ATAAGACAAT
crTI'TGATAT
GGGGCGTGGA
ATGACAGCGA
ATCGTGAAGA
CGATCGCTT
CTI'ATATCAA
AAATCATTAA
CTAAGGCTAA
AGAGCATGAT
TGTl'A'TAAA
TI'CACGCCC
:AGAAAGAGC
TTGTGGGGGC
GCCTTGTGAG
TGCGCTCACC
CAGAATGGTG
AAGAGCCTA
GCCTCATGAC
GAGTCGAT'G
TTATCCAGAA
CTI'AAAACTC
CCATITCGGAT
GCAACGAAAA
ATTGAAAAAC
CA 1'GTTTCT
ACACACGACG
GCACATGGGG
TCATGAAGAA
TTTGAAAAAC
TATTGTCGT
AGATTTCGCT
TAGTAAAAAA
AGGCGATAAA
AAACCATI'TG
CAATATCTI'A
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1140 1200 1260 1320 1380 1440 1500 1560 1581 INFORMATION FOR SEQ ID NO:348: SEQUENCE CHARACTERISTICS: LENGTH: 372 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .372 PCTU3 96/09122 !PENUS 18 DE C 1996 302 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:348
GTGGTGGTGG
GGTATTCCAA
ATCGCTAAGA
TTAGAGCAGG
CTTTTAGAAC
dAAGTCATGC
TGCGGGGGCC
TTGAGAATAT
TCATAGAAGT
ATGTGCCAAA
CTCAAAATAG
ACGCAAAGAA
AAGCTTTAGA
GT
AAAAGACGCT
AACTTTGCGA
AATGCGCGTG
GGGGGCAGAG
AAAAGACATG
ATTGGGTTAT
GTGCCTTTAG
TCAAACTGTG
GGTGCTGGCA
TTTTTGATTA
CCTTTAATAC
AACGCTTTGA
CGCAAAGCCT
CTTTAGAGGC
CGATACTCAA
GCCCGGGTCT
CTGGGGTTTC
AATTTTTCCC
RATARAGGGG
CATAGAGCTT
TCTCACTCAA
TACGATAAAG
TAGCAGCAGT
GGCGGAGTAT
120 180 240 300 360 372 INFORMATION FOR SEQ ID NO:349: i) SEQUENCE
CHARACTERISTICS:
LENGTH: 330 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .330 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:349
GTGGAAAAAA
GTTAGAAACG
TGGGAAAGCT
ATTTTAACCG
CTTAAGCCTA
GATASCTTTA
TCAAACCCTA
TCCAATCCAC
TTGAAACGAA
CTAAGCATTT
TTAACCATCG
ATGGGAATTT
TGCCCCTAAA
TTTAAAAGGC
GGTTTTAGGG
AGGCTTAGAG
TTTGCAACTG
AAAGGGCATG
GATAGCCCTT
ACTTCTTTTG
GAGTTTAACG
ACAGAAAGGA
TTGGAAGCGA
TAATAGACTA
AAACGCTTAT
CCTATAATAT
TCAAACGGCT
ATCAAAAAAT
TTCTAGCCTA
CAATGGCGTT
CGCTTCAGCG
TGTTTTTGAG
CATTATAGAC
120 180 240 300 330 INFORMATION FOR SEQ ID NO:350: SEQUENCE CHARACTERISTICS: LENGTH: 1791 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION .1791 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:350 PCTP2; 96/69122.
IpENjUS 18 DE. i996 303 ATGTCTAATC AAGAATACAC
CACTC'TTGT
GCrITTGGATA
ACGCCTAGCA
GGTATAGGCA
ACGAAGAGT'
CAATTTGGCG
AAAAAAGTTA
ATCAGCGAAT
GATICTCATT
ATCCCTTTCC
AAAAAAGAAG
ATGAATAAGA
GATAACAGCG
ACGCTTTT
GGGGTCAAAC
TCTTATGA
CGTGAAATCT
ATTI'TAAGCG
CCT rGGGA T1'AGAATIGT
AAAGAAAAT'
TTATTAAAAG
TTGAGCGATG
TTAGAGACG
GAGGTAAAAG
ATTAAGGGCG
CCAAATGCGA
AAAACTTTAG
AAAGAGCAGT
ATI'CTAATAA
AGCTGAATIA
TCCAT1'TGAG
TGGATAAAAG
TPI'TAGCGC
TGGcI-r'TA
CCAGTCATCA
GCGTCAAAGA
TTGCGAGCCG
cTA'TT1Ti'T
FIAAAGAAGA
GCGAATTGAA
AGCCTTTGAG
ATATCCCTAG
'1 2TATGTTAA
GGTGTTA.A
TACAGCAGAA.
AGATTGAAAG,
AAGTGT"-AAA
TGAGATI'CTA
TAAAAGAAAA
CGTCCCCCCT
AAATrTGATGC
CTAGCCATAG
ATCAGTII'AA
TAGAGCTTTC
TGATGGCTAA
AATTAAACCC
TGAGCGCTTT
CTTCCAAACT
AGAGA=iTr
TTGATGCTA
TTTTIGATAGC
CGATCTCATC
TrI'GAGTGGG
TTCGGCGTTC
AGCTI'ATGCA
GGAGCAAGGC
TrGGGAGATT
AAC'TTACACC
AAAATGCGAT
AGAAAAGGAT
CTATATCCAT
CAAAGCGCCC
ACGGGTGTFI'
AGGCGTGAT'
TAAGATTTTA
GCTGAGCAAG
AGAAGGCTTG
rICTAAAGAC
TCAAAAAAGC
TIAGAAAAA
GTIT'1GTGATG
TGAGAGI'TG
AGA'I'ITAATC
TGGTCATCTC
TTGGATGCGT
TAACCATGCG
TATCTGGTTIG
GAAATCAACC
TTAAGGGAGT
ACCGATGAGA
CAAAAAAAAA
GAGCATTTAG
GATAAGAAAA
ATGGTAGCGA
TGGGTGAGCG
ACAGAAATCA
GATAGCGTI'G
GATACGAAAT
CAGATCAATC
TACAAAGACT
AATAAAGTGG
TTTGATTI'GT
ATCACTGATG
GACAGCGAAG
GCCAATATCC
GATAACAAGA
TATGGGGAT'
AAAGGAGAAT
XITI'ACTACC
TACGCTCAAA
CCAGGCGTGA
AAAGAGCTTG
AAAGCGTTG
ACTI'CAGCGG
CAAATGGGGC
ATTTTGCAAA
C'TrATGATG AGCTP1'TGGA
TGATTTCTAA
AATTAAAAGG
CCTTAACGAT
GCACGATCGC
AAGATAGCGC
GTAAGATI'GT
ATGGTAAGGG
CCCTCTTrT
TTAAAAAGTA
TTGAGGGCGA
AAGCGAGCGC
TT'TACCAATC
AAGGCTCTTr
TTAGGGTGGA
ATGACAAAGA
ATTTGCCCT'
GTTCGGCT'C
AITACCATAA
TTGAA).ACAA
GGAT'TCTIT
'TTTAGGCGA
AAGGCTATGA
ATGAATACGA
GTTTGGCAGA
AAGAAAATCT
TGGcTrTAAT
AAAGCGTGCC
AACTCT1'AAA
GGCGAAGCTT
TTI'GATGATC
CGCGAGCGAC
GCTGAATACC
TAAAGACAAT
TAAATCAGGC
CTTAATTGGC
CGITCAAACC
CAAGTITGAA
AAAAGAAGAA
TTICTGAGCAT
AGGGGATAAT
TATGGAAA
G'T1GCGCAT
AGAATACACG
ITATAAAAGC
ATTG7I'GCCG
GAACGTGAGT
AGTGAAAAAG
ATTCTATGAG
AGAAAAACTT
AAAAGAATAC
AAATTrrAGAC TGT'rTTGTTA
TAAAACGCCC
AATCCATGAT
TAAAGATGAG
AGGCGATGAA
TGAAAGCAAG
ATGCGAAGAT
T
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1140 1200 1260 1320 1380 1440 1500 1560 1620 1680 1740 1791 INFORMATION FOR SEQ ID NO:351: SEQUENCE CHARACTERISTICS: LENGTH: 468 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE:
NO
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .468 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:351 GTGAA TIAG
AAAAAGCATG
TTTTTAAAGC
TTAATAATAA
CCTTTAATCA
ATTAAAAATA
ATAAGTTTT
TATCTTATC
GGGCI'ACTA
FIGGTATTGA
TCCACCACCC
ACGCTCTAGC
TCGTGGGCAA
AAGATCAT
TAAAATCTTTI
TCATCAAAGA
CACGCCCCCT
AAACTACACG
TAAAAAAATA
CAATCCTAAA
TCCCCCCTAT
?I'TTGAGATA
TGCAATTTTA
AGCTAATTT
TATI'IAGTGG
CT1' TAGACA
GGAGCGGATA
AGAGAAAATT
AACGATAGAA
GACAACGATT
AAGCCGGCGT
AAGCAATTTA
ATI'GCGCTTA
CCGCATGTGG
TTGACCCTAA
ATGGCAI'AG
CTTCCTTI'AT
TGAAATCCCG
TTATTTGCGT
AAGCTATT
cAAGCTIWITA
TAATAAAGAG
GTGTGATGCT
CCAAGATGAA
CAAACAAGAT
AGATT1'AGGG,
GCTACACCCT
120 180 240 300 360 420 468 PCTU9 96 09 122 IpEAAS 180EC1996 INFORMATION FOR SEQ ID NO:352: SEQUENCE CHARACTERISTICS: LENGTH: 471 base pairs TYPE: nucleic acid STRANIJEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .471 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:352
ATGAAAAGCA
TCACAAGATA
ATTAAAACGC
GAACATTCI'
TATTITTGC
AACCCCTACY
CATATTCTT
ATTTATAATG
TTI'GCTCT
ATTTTAAGGT
AM.ACGATTT
GGGTGGATT
CTTITATCA
AACGCAATGA
GGACTAAAGG
ACCCTCAATC
TATAATTI'
GGATTATAAC
GTCCAATGCC
TGCTAAAAAA
TAGIITCACC
G'TIAAGTTC
CACGCTII'AT
CGCCCCCATG
GTAGTITGTC
TACTATITGC
TGGTATCTCC
TATTTAAACA
CCCAT TTTTC
CAAATCAGTI
CTGGYTI'ATA
CGAATGATI'A
AGTIAGAAGG
GCAAACAGGA
CTCCACAAAA
TGATGGATTA
AATGGTACCA
TTAGAGTGCC
CCCAAACTAA
AATTI'CATGC
CAAAAAATTr
TTTGCACATC
AGCCCCCAAA
TCTAGGCACT
CCCTAATATC
TGTATI'TAGG
CTGGTTTCAA
C
120 180 240 300 360 420 471 INFORMATION FOR SEQ ID NO:353: SEQUENCE CHARACTERISTICS: LENGTH: 573 base pairs.
TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .573 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:353
ATGGGCTI'GA
?I'TGACTCT
TATGTGGGGT
GGAGCGATAC
ATCGGTATCC
WATACCATIT
GGGGTGCTA
AAGCTTTTCA
TGGGCGTGTC
TAGCTGATGT
ATAACTTTGG
GAI'AGCGCG
CCATI'CCTGC
TCTI'AGAAGG
TGGTGAGCAA
TCTTAGTGI'
GCAAGGCTTA
GGTCGCT171
GCGTATAGGC
ATTCAATATC
GGCGGCGGTA
CAATACCGAA
TATCCGCTAC
GATCTTTTA
CCAAACACCA
GGAGTCGCCC
ATGGCGGTGA
AGCACCAACA
?1'GGTGGTGC
AAGTI'ATTT
CCTAATTTIA
TCGTTAGTGT
CTAGCAAGTT
CAAGCCTTAT
GCGCGT1'GT
CAAGCGATCC
TIGCGTGTT
TAGGCTTTAT
AAAAAGTCAA
TTGTGCGCCC
TGGTATTGAA
TACTTACTTT1
TGTGATTTTI'
CTATI'CTI'1C
ATTAGATAAT
TGTCTIATTA
GTGGAAT:CTC
ITTAGAGGCT
120 180 240 300 360 420 480 POT/US 96IO91a IPENUS 18(2'G IJ96 ?I'GAGCGTGT TTATGGGG?1' GTATITGATC TATGGCATCA ?TCGGTGGAT CTr*=AATG GTAAAAATI'A CT1'AATAA AAATAAAAGC GCA INFORMATION FOR SEQ ID NO:354: SEQUENCE CHARACTERISTICS: LENGTH: 270 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .270 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:354
ATGATAGGAG
GTAAGTAGGG
AATCTTITACA
CGGGTTAAT
GTATTATGTG
T1'TACCCCAA
AGTTAGCGCT
TGAATGCTCG
TACA TrTCRT
ATGAAAAAGA
TAL'CCAAA AAGCAACTAA GGCTAATGGT ATrCTTACAG TATCGTTATG AARAATAATA TAGAAGTC'IT GGTARCGTGT
TCTATTACGC
AACGCCCCTT
ACGCCTATGA
AAAGGAAACA,
TTGATCACCG
AGTCATATTI'
CA'I GAAGCA
TTATGAGCAG
CTCTAATCAT
INFORMATION FOR SEQ ID SEQUENCE CHARACTERISTICS: LENGTH: 831 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii). HYPOTHETICAL: No (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .831 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:355
GTGAAAATAA
TTTGTAAAAA
TlTlr'IGGCGG
CGTAAGATTG
TGCATAGAAG
CAATATTTGT
CCTTCTACGC
CCATAATGAT
TI'CCCACCAA
CGATGGCTAT
'TITTGAGAA
TCAAACCCGA
TGATGCCAAC
CTAACTTT
CCATTCCTGA
TAAAGAITIWI
AAAACAAGGA
CATTGTI'GTG
ATGTI'TGCCT
CGCCGGCTAT
GACTCACA T
TTACTTGTCA
TTATGCGATC
AACCACTATT
GCAAAAAAGA
AGTITrAAACG
AATTATGAGA
GTGG'rITTA.A
AGTGGCATTG
TGGCAAGCGC
TCTTTGACGA
GTAGAAAAAT
TGAAAAAAGC
CCAAAGATCC
AAAATCAAAA
AAGATATTAA
AAAACCCIT
GCGATTIrTAT
TCAATI'CTAA
AACGAGAGGG
GGGTTTTCTITI
GAATGTGTTIG
TCCTI'CACCA
CGGTCCGT1'G GTrGcT'rGAT
GAGTWAAAAA
AAAAGGGCGA
120 180 240 300 360 420 480 96091 2.2 ,&~Ssw ub
TCGCAAAACC
GATAATAATC
CATAAATATT
ATGCCTTGCTA
GTGCAACAGA
AATCGCGCTT
ATIITCACAT
TAAAAAATAT
TGGCGCGTCG
AAGAAGTGCC
GCGATAACTC
CAGCCGAAGA
CCATATTCT
CAACAGCCGT
CGTAACAGAG
TAACGCGCAC
C'TTGTCTTG
GATTCAAGAT
TGCATTAGCC
TGGTCGCCAT
AGCGAA?1'AG
AAACGCATGG
TTAGCGACAC
CATGAATGCG
rI'GATGTGCG
TATCAGGTGG
CGCAAAAAAG
GAGACTATGG
AATTTAACCC
CGATTTTGCG
CAAACAGCTG
CTTGAACGGG
CCCGTTIGTC
cTI'GGCGGTG ATTGACTrI!A
T
INFORMATION FOR SEQ ID NO:3S6: SEQUENCE CHARACTERISTICS: LENGTH: 174 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .174 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:356 GTGCTAACGA GTGGGGACAT GATCACTTGT CCGTATIGCG AGTACGCATG AAAGTAACGC TCAACCTCCA AAAGXAAGCC GAAAGCCAAG AAGAAAGCCA AGAAGAAAGC CAAGAAGCCG GGCGTATITT RTACGCTGAG AACCAAAAGA AAGCCAAGAA TCCG'TrTGAT TGTT 120 174 INFORMATION FOR Z"EQ ID NO:357: SEQUENCE CHARACTERISTICS: LENGTH: 837 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .837 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:357
ATGAAATTGA
GGCTTTAGGG
GIT~IITC
GAATTGGTAG
TTTATGGGC
,%TTTTAGTCC
ATGACCCTTT
GGGGGTTAGA
ACACGCATGA
GAAAGCG?1W1
GCTCTTT
AAAAAGCCCT
CACAAGCCCT
GTCTGAAATI
GCATI'TGGAA
GAATGACTGC
CGTGAATGAG
TAATATTATI'
kATAAAGCCA
TTATTAGGCT
TTAAGCCACG
CCCATAGAGT
CATGTTTTAA
TCTCAATACC
AAAAGAAT
TI'GTCTTGCA
AAGAAGAAAC
AT1'TATTAGG
TCCCACGGCC
ATTTIAAAAGA
ATCGCCAAAA
AAAAGAAAGG
ACGCTTTT
AAGCTGTGAT
TGAAACCGAG
AATAGGCGAA
I it qirnm ev'~r 1CTKK 96/09122 IPEA/US 18 DEC 1996
ATCGGCATAG
AT1'TATGCGA
TTTTGTCTAA
ATAGAAATGC
GT1'CTCAAAG
GAAATCGTTT
GACCAGTDAA
AAGGATTTGA
GGAGCGGATG
GCGATATITC
AAGAGCGTGT
TrGTCTCTAA
AACCGCACGA
TTTAGCCGC
AGAGCTTGAA
GcGGcTI'TGA
CGTGTCCGTG
ACCAAAAGCT
TTTTTTAAAA
CCCGCCCTAT
AGcccTITI'r
TAAATTAAAA
AGAATGCTTG
TAGAGGGTTT
AGTTTGGCTT
TTAGAAGTGG
CAA.ACGCGCC
ATCGCTAGAA
GGGGGGGTTA
ATCCCTTT
GAGTTTTGCG
GTGGGCGTT
TAGAAAACCC
CGTTAAAAAA
TTTGGGATCA
ATTATCCT
AAGGCGATGA
TGGTTT'GTGA
GTTATGATGC
TAAAAAGTT
TAATCTCTCT
TATTGAACGC
TATGCCAACG
GGAAAAATCC
AATCTTAAAA
A)ATGGGGTAT
AGAGTFI'TAC
TTTAAGA
INFORMATION FOR SEQ ID NO:358: SEQUENCE
CHARACTERISTICS:
LENGTH: 108 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .108 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:358 ATGATCTT TCATTGGGT' TGAATGCTCC GCATTAAAAG rTTIAAC
TTGGITAC
ATAGTITTA AAAGYTGGCA CTATAGCGCT ATAAGACTAA
TTGTTATA
INFORMATION FOR SEQ ID NO:359: SEQUENCE
CHARACTERISTICS:
LENGTH: 387 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .387 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:359
GTGATCCAGT
AAGGGTCTT
ATGCCCATAG
TTTTCAT
AAAATGAGT
CTCACCCTAA
ATAAAACCAA
AAAAACGAGA
CTAGCATGCT
TAGAGAGCGC
ACAAACTCTA
CAAAGAAGCC
AAGTI'TAAGC
TI'TTGGGATC
GCACAAAAAC
AITGAAGATG
TTrTAAGGG
AAGGTTTCTA
T-TrGGCG7I'
GAATTAGAAA
AAAAVFTATT
TTTATAAAAT
AAATC'TTTI'
TGCCCAAACG
ATGCATTCCA
TTATGCTAAC
CCCAGAGAGC
AGCGTTIGcTI'
ATTGGACACT
ACGATACGAT
PUT/uS 9 6I/O9? Z IPENJUS 18 D EC1996 GCGCTAGGGG TGCGTIGA AGACATCA GGGGTGAATG AAGTCAAAGA
AGAATTACTA
GAAGTGATRG AT1TTMNAA
AAAACCC
INFORMATION FOR SEQ ID NO:36 0 SEQUENCE
CHARACTERISTICS:
LENGTH: 381 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL
SOURCE:
ORGANISM: Heliccbacter pyloni (ix) FEATURE: NAME/KEY: misc-feature LOCATION .381 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:360
ATG'TTGTAG
GGATTGGATA
GGGATTTTGT
GAAATCTCCA
AAAAAACTCC
GCGAATAAAG
GGAAAATTTG
TrAAAATGGT
TTTCACAAAC
GGTATTI'?TT
AAcGCTTAGA
TTAAAGAATT
AAGCCCTACA
ATCAAAAAI'
GTTAGGGTTT
AGACATTATA
GGCTAAAAGA
AGAGATTCAA
AGAGCAAGCC
CGATCACGCA
TTGATCCTFI'
GAGCG?1'CTI'
TTGCGTTCAT
GCCCAACTTA
AAAGAAAAAG
AAAATACGAA
TAAGCCCTTT
TAAAT?1'CCT TTT1TGCATI'C
AAGTGAGTAA
CTGAATI'GAT
TTACAAACCA
GTGCGCTACT
CTI GTTTGTG
CAAAAGCCTT
AGAACATAAG
TATTTICTGAT
AAA.TGGATGT
120 180 240 300 360 381 INFORMATION FOR SEQ ID NO:361: SEQUENCE
CHARACTERISTICS:
LENGTH: 885 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii),MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .885 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:3 6 l ATGAGGGT-Ir
AAACCGCCTC
TTCAATCAI'
ATCGTATTTTI
\\TCACGCGCG
TAGAGTGGAA
AAAC 17171-AA
TAATCAAAGG
TCTCAAACGC
cTAAAAGC
GCTTTAAI'C
ATATTGGTI'A
AATACAAAT
GAGI'CTATG
TCTATI'AGCG
CCTTGTTA.AA
TTCAGGCAAA
AATACTGATA
TTAAGATAC
AAAAACGCT
CAGGATTTAA
GAATTTCAAA
CTCTACGCTC
AGTGGGATAC
AAATAGGTAT
TCAAAGCGI'
AAATCGCTGC
AAGAACACCC
AAATCGCTCA
GCCCACCAAC
AATCAATAAC
TGcc1-rGTTA T1GCTGCTAAT
AAAAGACGCT
AAACGCCCCT
120 180 240 300 360 POT/US 9 6/ 09122a IPENJU?- 18 DE C 1996
TTTGA'TTAT
ACCCCTTTA
AAAATGGATT
CCTAAACTAG
CCTAGTCTTA
GCCACCAAAA
AACCTCTCTI'
ATCACTAAAA
CCTAAAGCTA
TCA'TrCAGC
AAGAAGAAGT
CITTTAGAAAT
CCCCTTATGG
AATCTAAAAT
ACGCTCAAAT
ATTI'CATCAT
ATGGGGCTAA
GAGCTATCTI'
GGATATI'GCT
CTATGCTAAA
TCTI'AAAGAC
AAAAGCCAGC
CATTT'ATGGC
AGGcTTITGGA TGATAAAACc
TAACCCTITA
TAAAGAATAC
AGACCCAAAA
GGCGTGTTGG
CCTAAAATTA
ATCGAAGTCT
GC ETCTATI'
GCGTTATCTT
CTrrATAACC
GCCAAAGT
GGcTATATI'G
AACTI'ATGA
'TI'TATrGGAG
AACGTATCGC
TGGATCGTTTI
CTCAAGCCCA
TGATCGATAA
CTATTGAACA
?I'AAAGATT
TGGAT
TGAAAAAATA
TGAAAATCTA
TATGGCTAAT
AAAACTCACT
TCAATTCATC
AAAAGACAAA
AGCCTTAATC
?'ITATrCAGC 420 480 540 600 660 720 780 840 885 INFORMATION FOR SEQ ID NO:362: SEQUENCE CHARACTERISTICS: LENGTH: 378 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .378 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:362
GTGGCTTTAT
AAGGTTACTT
CTCCATAAGG
GATTTIGCAT
GGCTGGGTT'
TTGTTTGCAA
TGGTTGAGCA
TAGAGCCAAG
GGGGTCTI'GT
ATTATAAAGA
CAAGCACCAT
TGAAAAAAGA
CTTGGTATTT
AGAT1'TAT
CGTGATGTAT
AGCGTTAATC
CTATCTCACT
TATCATSCCT
AAAAT'rGCGT
CTTGCTTAAA.
CTTIACCGAAA
TTTGTGGTAG
TTCTTTGAAA
TTAGGCGGGA
C'TTTGAGCG
TACATCACCC
AGTATCAATA
GCGTGGTGT
AAAGTC 171 TT
TGRCAACCTT
CGCACTTTT
CTTI'AATTGT
CTCTCGTITTT
GATITTCTCG
TGATIGGTTG
TXITI'TTATG
AGGCCCTAAA
GTTICCATT
120 180 240 300 360 378 INFORMATION FOR SEQ ID NO:363: SEQUENCE CHARACTERISTICS: LENGTH: 726 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc-feature LOCATION .726 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:3 63 I qTjTi 19 A /E OC 19919 6 a
GTGWGGGCTTA
KITTGAAGAAG
GAGCCTAGAA
CGCGTI'CAAA
AAAATT~CAAA
TTGGGCGTGG
GCCCTACAAA
TI'GAAGGAAT
GCTAAGAAAT
GGGCATGTCG
GCCAAGCGAT
GACAGYAGTA
AAAGGA
TGAAAATAAG
TGGCTAGA LT
GATTGGITI
AGCATTTCAA
GCGTCGCCAC
TGGGAACGAT
GCGATGAGAT
TTTATCAAGC
TTTrTAACAG,
TGGTGTGCAG
TGAAAAAGCT
TCCCTGTCGG
AT'ITAT'GGGG
TGAAGAATTT
AGAAATCGCT
AGAAGACGAA
CAATTCCATA
TAGTrGAA cGCT1'TTTAC
GTTTGAAAAG
C'rrAGTAGAA
TGGGGGCGTG
TCAAAGGGAG
TCAAGCCTTA
CGGAGTGTT
TGGC'TI'TAG
TI'AAAACACC
TTAGGAATWI
GGGCGTTTGT
GCCGAGAGCG
CCTTTGA.AA
GATI'IGGGCG
ATCATI'ACCG
?TI'TGCAACC
TATITrI'CC
ATGGCGTATI'
TTGTGGGGGA
GGGGGCAAAA
AGCTCAACAA
TTAAACAAAT
ITGATATAGT
GGCAGGTTIT,
TCAAAAACAG
'TITAGAACC
CITTTGATIGC
AA?1'GTTGTG
ACAAGCATTT
TCAACCCTAC
TTTIGGAACGC
AGCGATCAAA
GCTTTTAAAA
GCATGACAAA
GGCGTI'IAGT
AGAAAATCTA
CGTGGTGCGT
CAAACGCATC
GCCTTTTA.AA
CGAACAATTA
CCCCCCTAAT
AATCATCAAA
INFORMATION FOR SEQ ID NO:364: SEQUENCE CHARACTERISTICS: LENGTH: 453 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1 .453 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:364
GTGAGCGAT
TGCGACGTI'
ATTGAAGAGG
CTTTGTIGC
GCGGGGCGTG
GCTI'ATAGCG
GAGCCAGGCC
GATAGCGTr
CTAACGCTT
TGATCAAT'C
TTAAAAAGCA
CCTTATTAAA
TGAGCATGCT
ATGCCTTGCG
CGGTGAAAAG
ATGCTI GGA
AAAGGAAGTG
CGCCGGTTAT
ATTT'AGCGTG
AAACAAGCCT
CTITTTTAGGC
TTrAGAGCTT CAA71'GGGAA,
AGTG;AATGCG
TTTAAACA
GGGGTGTTvTG AAT'TTrCG
TATTCTAAGA
CAI'ACAGCG
AAGCCC'ITTA
AAAACCGCTT
GCT
TCAGCGCTAA
GGAGCGTGGA
cCC'ITTTGTGA ITIT CAATCT
CGAGTAAGCA
ACGTTCAAGT
TTGAAAATGA
AGAAGATCAT
AGACACGCCC
AGTGGTGCAA
TTrCTTCCATA TGCCT AGAG
GTGTTTGA'TT
TGSAGCGGAAA
120 180 240 300 360 420 453 INFORMATION FOR SEQ ID NO:365: Wi SEQUENCE CHARACTERISTICS: LENGTH: 462 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE: NO -7 (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori PCT/US 96/091Z2.
I1PENUS i8SDEC1996 311.
(ix) FEATURE: NAME/KEY: misc_feature LOCATION .462 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:365
GTGATAGTGG
TTGGTTATTT
TCTAGCTCTT
AGTGCGCGCA
CAAATCAGAG
CTCTCTAACA
GATrCTAATG
AAAAAACAAG
CGTGGCTTT
TAGTGGATAT
TTATITTGGCT
AATGCTACCA
AGAATTT1AAA
TCGCTGAAGA
ATGAAAACCA
AGGAACTGAA
TAGGTI'TAAA
TTGGGTGTAT
TTTAATCGCT
ATTCAGCCAA
AAACCGCTCC
AATCATTTCA
CAAAGACAAG
AGcTAGAAAG
AGCATTGCGT
AGCGATGTGC
TTACTAATCA
AAAATGTI'r
AATCGCAAAG
AAAAAACAAG
C'TTTCTAACA
GATAAGGGGG
TTCTATITT
GCCAG~iITI'
AGTGGGGCGT
CGTI'AATCCA
ATGCTAAAAA
AAGAGTCCCA
1'TACCGAAGA
AT
AATCACTCTG
ATTGGACACT
GA'ITGTTATA
AAGAAAAAGG
TTZ'rGAAAAA
CCACAAAGAA
AATGATTCTC
INFORMATION FOR SEQ ID NO:3 66: SEQUENCE CHARACTERISTICS: LENGTH: 537 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL SOURCE: OPGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc..feature LOCATION .537 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:366
ATGAACTACC
GAAATCACTA
AGCGAGCAAG
TTGGATIr1
CTGACTAACG
GAGTTTAATA
GCCGAGAACA
AGACT1TAA
ATCACAAAAA
CTAATCTACC
AcGAGcT
TGGAATTAAG
TTAAGAATGC
CCGGCGAGAG
CGAGCATGCA
TTAP.AAGCGR
CGAGCTATCA
ACAAAACCCR
TAACAGCGCT
AAAGCAATTA
CCTTAAATG3C
GAATGAGATT
CTTGAAATI'A
TGCCAACGAG
AATTAAAARG
AATCTTTI'A
AAGCCT1TGAA
TTAGRGATAA
CAAAACGCTT
ATCGTTAGGA
GATAGCAG'T
AAAATGAAAG
CAGGAAGTAA.
CTAGAA.AATC
AACCAAGCCA
GCGATI'AcAC
GCGAACAGCC
TAAGGAGCAA
TTrTTAGAAGT
TAAGAAATTC
AATACGAGCG
ccAATACCTT
AATTGATAGA
GAGATAACGC
AAGCTAAAAA
AGAAGTGAAA
CGCGcAeTII GcTI"ITGAGT
CATI'GAGTGG
cTTITTAGC
AAACGCTAAC
AACCACGACA
TAACAACCAA
CAACAGC
120 180 240 300 360 420 480 537 INFORMATION FOR SEQ ID NO:367: Ci) SEQUENCE CHARACTERISTICS: LENGTH: 480 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE: No -7 ICfi 96/ 09 1 2a2 ME 0 1 9 (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-..feature LOCATION .480 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:367
GTGTTTGCCA
CCCATTWTCAG
ATTTTrATTGG GCCGTCCC?1' TrI-rCACACT
TTGAGCGATA
ATCGGGTTTC
ATCATGGGGC
CTGACAGCAG
GATCGcAAAA
ATITTATCGTI'
TAGGGCGATT
TGITTTGTCAT
?l'ATTITI'GG
CGGTT-AAAAT
GTITTTAAAGA
TAGCTTI'CT
ACCCATI'GTG
CCACCATCAA
TGTCT7I'GAG
AGGGTTTTICT
CATGATCATG
TGCGATCGGG
AGAAATCAGC
ATGGGGCTI'A
GGGCAAGCCC
ATCATTT'ITAT
CCAGAATTAG
ATGGCGTTCC
AAAACCCACC
TTTGTGGGCA
CTGGCCTTTA
CCATGGCGAG
T TTTATTIGTT
TTGTGGATCA
CTAAAAACAT
CTATITTTATG
CTCAATTCAA
TTATTITAAT
GCGI'ATI'RG
TGCTITATIGAY
AGCGATITI'A
cAGCTI'AAAA
TGTCAAAGCC
CTTGGT GTrA
CCTGCTCGCT
CGCP1'CGGCT
TAAAATCT
120 180 240 300 360 420 480 INFORMATION FOR SEQ ID NO:368: SEQUENCE CHARACTERISTICS: LENGTH: 282 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .282 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:368
ATGTATGGCG
TTGTT GAAG CAGTTGCG?1'
GGGCATACTI'
AAAAGCAT GC TGAAAGAGAT TAAAGATAAA GCTITI'TGG GGAAAAAGAA TCCAAAAGCG CTGGAGCCAA TATGCGTGGC GAI!ATGGGG GGATCAATCA TrTI'TGGC
ATGACAAGC
GATTTGAAAA
ACCCCAAGAG
TATTTATGA.
GGGCTTTC
AACTCCACAA
AATT1GGTGAG
TGCCACAAAC
GTTI'GAC?1'
CA
TAACGATCAT
CATGTTTGGG
CAGTGTTCTA
GAAAGCI'GT
INFORMATION FOR SEQ ID No:369: SEQUENCE CHARACTERISTICS: LENGTH: 438 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (v)ORIGINAL SOURCE: ORGANISM: Helicobacter pylori !PEN/US 18 DEC 1996 313 (ix) FEATURE: NAME/KEY: misc -feature LOCATION 1 .438 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:369 ATGACTTTAG
ATGACTI'ATT
ATCAAAACCA
AAAAAGACCA
ATCTCTITTG
GAWWGGACAG
CCGGCGGGCA
TC'ITI'TCTGC
CACAACGCTT
TAGAAAATTT
CTAGACAATT TACCCAGTAA CACACGCTrI'
GCTTGAATGA
AACCI'CAAG
AAATCGCC
AGGGGGGAGT
AGAAAGGCTC
TGCCCCGCAT
CCCTATITG
GCAAGCCTT
AAAAGCGCAT
AAAAATCGCT
TrGGACCCGC
TTATCCCIG
TrCATTTCTA
TTGCCTGCGT
ATCAGTGATA
TI'GTCTAAAA
ATCTTAAGAG
ATTGTI'ITTG
CTI'AAAAGC
AAAAGCATAG
TGTGCGAACT
ACGCTAAAAA
AACCCTTTAT
GGGGCGAAAC
CAAACCCTA
CCACCCTAAA
CGCTAACATC
~TTTGAKAAA
AATCTACGCG
AGTCCCTACG
GCTATCTI'GG
INFORMATION FOR SEQ ID NO:370: SEQUENCE
CHARACTERISTICS:
LENGTH: 519 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .519 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:370
ATGGGCGTTT
AGCCATAAAA
CTATCCCAAG
AACCTCTCTC
GGGTGCGAA.A
GAGCCTAAAG
TTGAAGGCT
ATCCC1TT1GG
GGTTTTAAAG.
TGGGCATGT
TCCGCTTATA
ACACCCAAAA
AAATCTTAGC
AAGTGGATAA
ATCACGCTAA
TCATTCATAA
AATTACGCCG
GCTGTGAATG
CGcITTT
CCATGAAAAA
GACTTrTA ccGCTATGAT
CCTTTTTAAA
ACATTCCCTA
CGATTTGAAA
CTACGCITAT
CGATGCAAGA
TCATGGGTIT
AAGGAT1'TTG
AAAACAAAAT
TrAAAAGCTG
CATITACCACA
GCTATGAGC
AACGCCTTTG
AGAAATCGCC
GGATTI
1
GGA
rTTATTCAA
ACAAATI'GCT
T'rAAAAGCGA
ATITAAACAC
ATATAGAAA
ATGcTTAT1T
AAGT'ITTAAC
GCACAATCTC
CAAACAAATC
TCTCGCTAAA
GCCAAATAGC
TAACACCCI'
TICTAAACGC
AAACGCGCAA
120 180 240 300 360 420 480 519 CAAAAAGGCA GcAAAAAAGA INFORMATION FOR SEQ ID NO:371: SEQUENCE CHARACTERISTICS: LENGTH: 579 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) >(iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
PTS 96/091~2Z FPEXITS 18 DEC0 199 6 31.4 (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION .579 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:371 GTGAGTGTI'C
CTGCAACGAG
TTGAATI'IAC GCAATCGT1T GGGGAGGGTG
AAGGGATCCC
GAGA'rITIAA
AAAAGCATGG
CCTATTACAA
GGGGCATGGG
'rrrGCGI-lTT
TAGGGTTTGC
GAAAACCACC
CGGATAATAT
GAAAAAAAGA
AAGTGATAAG
GTGATCCCTA
ATAGGGTCAT
GCGTGCAAGA
AAGCGTGT
TGcGAATTTA TrTTTA IGAG TAAAT1'?ITA
GAATGACGGC
GTCTAGCTCA
?TTGATAGA
CACCCCGGCG
TTTAAAAACC
TTCTACCAAG
AAccTTTCGC
GGCCCCGGTI!
CCTAGTAATA
ACcAACAATA
TCGTITAAAT
GcGATGAI'G
GAAAACATI'C
GTGTITGGGG
AAAATCCCTI'
CAATCGCGCC
ATGCGAGT
TGATTGCTI'
TCCATGCGGT
TTTCACCAA
TTTTAI'IGCA
TGGGGGCGGT
TCAATACTGC
GGTATAATGC
CTr1'TITAAA
ATCTCTGCCC
GGGTTTGAGT
GAAAT'GGTTI
AGTGTTAT
TAATAAAGTC
CGCTTCAGCG
TCTAAI'ITAT
AGCGT1'TGTG
AGCGGTGATG
AAGcGTTACA 120 180 240 300 360 420 480 540 579 INFORMATION FOR SEQ ID NO:372: SEQUENCE
CHARACTERISTICS:
LENGTH: 312 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .312 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:372
GTGGCTAAAA
GCGATTGGGG
TCAAGCGCGG
ATTGAAAGCT
GGGCGCGAGT
T cmTAAGC
ATTTIGGTAGC
TGATAGAGCC
AGTTGGAAA
TGGATITGT
TAGAAGAATT
GT
GAGCGGGGTI'
TGTGTCTATT
ATGCGTGAAA
AAGACCCATI'
CACTI'GGGAA
TGCGATAAAG
TATGTGAACA
TCGGrTrCA
TATITCGCTCA
AAGACTAACA
CGACCGTGCA GCTTGCTAT CGCATAACAC
GAGCAAGCAT
AACTCACGCC
AAAAGGCATC
CTTCAGcTTA
TGGGCATITT
AGGTTGAAGA
GAITAAAGCG
120 180 240 300 322 INFORMATION FOR SEQ ID NO:373: SEQUENCE
CHARACTERISTICS:
LENGTH: 1065 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
~.ati~r~ pGT/US 9 61/091ka i 9PANUS 18 0E C 1996 315 (vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc~feature LOCATION .1065 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:373
GTGCGTTTGT
GCTTTGGAAT
TCTGCGAACA
TTGCCCATT
CAATACACCG
TTGAT1'AGCC
ATGGAAGAAA
TTGTTAGTGA
AAAGCCCAAA
GCTAAAGAAG
ATGCCCTTGA
AAAACGCTCA
G'TI'CTATCA
AAAAAAGTGC
AGCGTTTTAA
GGGCTAAAGT
TTCAGCAT
CTAGCTCTCA
TTAGA?1'TGT TGrTTTrGT TGATCATTT1' CCTTGC11rTT
CCCTGCTCTC
TGTTrCAC
AAACGCAAAA
AATACAACGA
ATATCAAGGT
cTITTTTGA
GTTTTGAACT
AAAATTI'CCG
CAGACGCTCT
GCTCGTTTT
TCGcTTATTT
TTATCATTAT
CAGGGATACT
GTCTTI'GGTA
GGGGTGGTAT
AGGCATTGAC
AI'ITrCACC
AGCGATGGT
TATGGATYI!
GGCTGTTI'AT
TTTAATTTAT
TGATTACGTG
TTITCGCCTA
AGACAAATAT
GGGCGCGAAC
CCCTAAAGTI'
TI'TATCCTTG
GTATGTGTTT
TTCGCCCAGT
CACGCTCGTT
CATTCCTGAA
TTAA
TATITCAAAT
AGCCTGAAAT
TATGATATTI'
TTA'fT1'ATA
TCCAAATGCC
GTGGGGTTGA
AAAGACAATT
TA'TTTTGATA
AAAGATAAAA
TGGA'TrTAC
GCTTTAAACA
TTAGACACCA
cATGCTTTAG GCGATI7GC
CTCGCCCGCT
GTTTGGGGGC
ATAGGCGTI'C
CTTAATAAGA
ACTTTTAAT
ACGCCGATAA
TATTCGCTCT
TCACCTICAT
AGATTAAG
ACGCGACTCC
CTTI'GAGCGT
AGATTAATCC
CTI'TAGAATC
ATGACACTAC
CCACGCATr TTrATCAAAA
TGCGCCAAAA
CCTTTITTGT
ATGAAAACCT
TATTCTTI'GC
TATCGCCCT
GATTG,
CGTGCTI'TA
AATGCCTGAT
CAATTACACC
TAAATCCAAC
CCCTATI'TTT
TTGTGTAT
rTCAGAGCAT
CTI'ATTGCAA
TTATGCTGAA
TATCTATGAG
AGAAACCTTT
CAAGCCTGCG
CGCGGACACG
GCCGTI'?I A
GGCTCTI'TTA
TTTAGGGAAG
T1'TCGTAI'T 120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1065 INFORMATION FOR SEQ ID NO:374: SEQUENCE
CHARACTERISTICS:
LENGTH: 717 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION .717 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:374
ATGATITATG
TTCCATTCGC
GCGCGTTATG
CCTAATGAAT
GAAATCATGC
TACAAACAAG
ACGCTTAAAA
cccATTTGCG
AATGAAGAAA
GGCGTTAAAG
GAAAGAGCCC
'T1'GA'rFTAG
GCGTTTTAGA
T1'TA'ITTGTT
AAGATTTGAT
TGAAAATGGA
CCTATAAAAG
CCTTAAGGGG
ACTTACCCCT
TGGTGGGTAA
AATICATCAT
TGGAT'TI'CA
CCC TAGAAGA
CCAAAGAAGC
CGGCTI.GTTT~
TGAAGAAAAT
TAAAAAAGGG
TTTTTrGAAA CGCTI'rAAT
TI'GGGGGAGT
ATACCAAACC
TGGGCCAAGC
TTTTCATGC
AATAGAAGTG
CACCCCCTTA
GTTGATGTTT
TT~GGCTATITr
TTAGACTTGT
GCTAAACTT
cGCCCTATCA
TI'GCGCATGC
TTTGAAGACG
CTAAAAACCA
CTGrGAAT GGAACCGCTr
GAGCGCATAG
ATGGGCGCTA
ATGcGTGGGG
TACAGGCTCA
TI'AAAATCAG
rrrATTCAAGG CGCATI'CT1TT
GAGAA.AACAT
AATI'GCTAGG
AACCCAAAAA
TGTTAGATTT
TAAAGCCTTI'
ACTATCTTAA
ACATGCTCAA
GGAGCGCTTG
AAATTACCGC
TGcTAT1TIT GT1TTTTTAAC TT'rAAAGCTA
TCAAAGCTAT
GTTAAAGAAC
AATTAACGCC
TrTAAAAGAA
AAAAGCGCAT
GGAGGTTTITA
TCCTAACGCT
CGCAGTA
120 180 240 300 360 420 480 540 600 660 717 AWKWO SOAFti P$MjS9i 0 12 2 DC1996 316 INFORMATION FOR SEQ ID NO:375: SEQUENCE CHARACTERISTICS: LENGTH: 867 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .867 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:37S
ATGCTGGCGT
GCGI'ATTGT
CCC?1'AATCA
TTTGAAAACC
GGATTTGATT
TI'ATCTTTAG
TACAGAATGA
AGCGATAA
AAA rACT
GCTCAAAGCA
GAAAACTCCC
GGGACATTGC
AGCGTTCAA.A
GAG'ITTCTTC
ACGCTCCCCA
TTTTAAAAAC CCCTAGAA 'TTTACTGGTGS
CGCTTTAA
TTG TITTAGT AGCGTI'AG CCTACTICAG GCr~rGA GGTTAGTCCC GGATAGVT TAGGGGTTI'T ATTGCTGC AAGAGGTTGG AAATAT C CAALATTACCT TAATAATA AGCAAAAAAC C TIG ATIC CT'TTTAAAAC CCAACTAC GCGCTCARGG
CTATAGCC
TCGCTGATAA AGTGATC) AAAAACCCCT TGAAAAGC TTTCAGCGAT
TTIACAT
GG
GT
Tr
;TT
A
:TC
AGCGCTIG
CTITCGCATI
TATGGGGTT1r I-rITTAGGCT
ITTCTATA
GGCGCGTTGG
TTAGTCTCTA
GAAAACAACA
TTCCAGAGA
GATITAAGCG
TATAACAGCT
GCCCCCTrrrG TTrriGCGA
CTI'TGGGTYT
CGGA'TTCAC
TATTTTATTT
CTAGI'FITAT
GCGTGTTTAG
GCGCTCAAAA
AT 117CAT
CAAGAACGCC
TI'CTTAA.AGA
CCGCTTACCC
ACAAGATCGC
CGTTTAIT
GCGAGATAAT
GAGCGCITAT
rT717CGTGGGG
YTATTTATTG
G!ITGCTCTAT
CCACCCITTIT
GGTGGATAAA
TCTI'AAAAA6A T'TTrAAAATA
CCAAGATI'TG
AATCAAACTC
TATCGc?11'A cATTTTAATA TrCTAAAAAA
GCCTTI'ACCG
TrATACCGCA 120 180 240 300 360 420 480 540 600 660 720 780 840 867 INFORMATION FOR SEQ ID NO:376: (i).SEQUENCE
CHARACTERISTICS:
LENGTH: 1308 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1.._1308 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:37 6 ~PEA/Us 8 LZ 9
ATGAACGATC
GcGTI'AGGGT
ATGTGGGTA
TGAATI-rGC
AAAATGAGTA
ATTGAAGAAT
TCTAAAAAAG
TTGAATCGT'
ATCACTGCGT
TCTITI GTGC 'TTrGAATA
GAAAAATI'AG
CTCTATGCGT
ACGCCCAATA
GACACCGAGC
ATTGAAAAGA
GAAAAAGCCC
AITAAAGTGG
TTrAAAAGT1GG
TATGAGCCTG
AAGCTTATGG
GCTTTAATCA
CTAAGCATG3T
ATTTGAACGG
AGGATATTr CCITTAT TCAA
AGAGCTIGGG
TACGCTATTT
CGTTIAGTAGA
TGCTAGGCAT
ATTATCCTAA
CTAAAATGCA
AACTCATCGC
AAGCCTTArI'
TCATGCCAAA
ATTACGAACG
cTTrATTTTC
TTGAAAAAGG
CACCAACACA
GGCTTATCAA
ATTAGGCGA
AAAGCTTIGGT
GTGAAATGAG
GCCCTACCAG
GGTGTATGTT
I' TAGACAAT
ACGCTTCCAT
ACAGCTCTGT
TAATGTI'TA
TTTATTGCGT
ACGGATTAAT
GGCTAAAAAG
AGAGCTAGAA
ATI'GCATAAG
TAAAGAAGAG
GAGTI'TGATC
GAGCGCTATG
CTTrAAG
CAAAATTGAG
GGAGGAAGCC
AGAAAATTAT
AGAAGCTCAA
AAATCGTTG
GGGTCAAATG
TGAGGGCATG
AGAAAAAA'T
TGGCTGGACG
AAAATIGGCGC
GCCATTTATT
GTGCATGGGT
GACGCTCAAA
GAGGTGCCT
GCGAAT'ITGA
TATTTICAATI'
AAAGCACATC
GCITTTAGAGG
CCGTGGGTCT
GCAAACACC
AAATTAGCGA
GCTAAAAAAT
AAAATrGAAA
CTAGCAGAAA
ATTAGTATTG
AGGATI'GAAA
AGGCAGATCA
GTGTGCGTGG
ATTTTAGCGG
GCAGGAAGT
CTI'AGAA
ATITTGAACG
GGCCAGCCTT
GGTGGACGAT
AGCTCGCCAT
TTGGGCAAGA
ATAACGAT
ATTCTCTAAA
AAATTTTAGA
AATGTAA
TGCACAAAAA
TACTACAATC
GCGCTTI'CG
TACAAGATAT
AGATI'GAAAA
AAGCAGAAAA
AGGArrl'CAA
AATCCAATAA
TCTCAGGGAT
TGGCTAAT'
TGCOAGATAA
TGATCAGC
TTATGCGAGC
CGCTAGGCAT
TTGATGAGT
AGAGGGCGTG
GGAGTATGGG
TGGGGATr GGGGAATTrrG
AAGCACCAAA
TAACGCTAAT
TAFI'ATGAT
CAACGAATCA
AAGCTTCI'G
TGTAGAAATC
GG TTI'ACAA
GATTGAAAAG
AAAAGAAAAA
GAAAGTAGAG
ATTACTGCGC
CGCTTTGGAT
AAAACCCGCA
TGATAATCTIG
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1140 1200 1260 1308 INFORMATION FOR SEQ ID NO:377: SEQUENCE CHARACTERISTICS: LENGTH: 342 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .342 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:377
ATGAAACGAC
AAACATTTAG
GGTTTAA
ITCTTGTTG
CTCGTTTCTC
AAGCTAATCA
CGATCAGCAA ATTGAAACAA ATAPLGTACAG CCTTTATTAT TAGCGCr T CTrATGGG CTCTTATAAT AAAACCTAGC TCAGCATAAT AAGCAAATAC TGCTTATGAC TCAATGGCAA AACTITrAC
AGGCTGTTCA
GCAGGGGTGA
mITrTATT
TATCTCCTAA
AATI'GGTTCT
AATI'CAAACA
ATATCAGCTC
ACACTACTA,
GCCACGCAAA
TA
TTCTTCA.AC
TATCGTTATA
TCCAATA 1'A TCITITG1CTA
TTCACAATG
INFORMATION FOR SEQ ID NO:378: SEQUENCE CHARACTERISTICS: LENGTH: 5 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) IPENUS 1.8 DEC 1996 31.8 (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION (xi) SEQUENCE DESCRIPTION: SEQ ID NO:378
ATGGG
INFORMATION FOR SEQ ID NO:379: SEQUENCE
CHARACTERISTICS:
LENGTH: 381 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION .381 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:379
GTGTTCACTI'
ATCACTTATG
G TTATCAG
GAATATGGGG
TTTGGCCAA.A
TTrGCTGGC
AAAGTATCAA
ATI'CCTTGGG GCAGGTTTC TTITCTCTAA GTATCGGTTr CTGCCGTTAC GGATAAAACG CAGAATTTGC
TTAAAAGCAC
GRATITI'AAT TrCTCTTGTG RCAGGGCTIA
TGATTTTCAC
CTAATGTCTC ACAAGGCACA GGGTTAATCT TCACTI'TT TGGGAGCGAT AGGCGTTCCT TGTT1'CAATI' CT TTT CTTGC ATcAcTTCTA CGGTGGCTI'T ATTAGAGCCA AGCGTGATGT TACTCTCGTI'
T
AGGGATCAAT
GATGGGTG
TTTTrGTGTTT ACCGGTGG?1'
TCGCGCTCGC
ATCTTACCGA
120 180 240 300 360 381 INFORMATION FOR SEQ ID NO:380: SEQUENCE CHARACTERISTICS: LENGTH: 537 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori i0P 1 242.
319 (ix) FEATURE: NAME/KEY: misc..feature LOCATION I1.. .537 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:380 ATGAkACCAT
AI'AAAAACC
PI'TCTATGGC
AGCGT1'rAG
AAAGAAACCA
GAAAAGATCT
CCCTCCCAAA
CTTITT 'TCA
ATITCTAAAG
TGCXTTIC
TTATrIrrITr
CTAGCATGCT
AATACGCGCA
GCGAATCTTT
TAAAAAAATIG
AAACCCAATI'
CCTTAATCAA
ATAGCGACGG
ACACCTGGAC
AGGGGT1-1'1
GGAATTAAAA
AAGGCATT
G'rrAAAGAI'
ITI'TGACGCC
TTrI'ATCATG
CAAGTATTTA
GI'GTGGTG
AGAGAGCAAT
TCCT1'ATTGG
AAAATCCITI'
GAAACAGCCC
TITAATGATG
TATAAAATCA
GCTAGAGCGA
CCGAGCGCTC
CAATTTIGGCG
CAGGCGATGT
GT'GGTTGAA
TAGAAGAAAA
TAGCAAACTA
AAGAGTCCAG
AACCCTTGCT
GCGAATTGGA
AAAGCCAA'rr
TGAGTATTGA
GGGTITTATC
TACCGAGTAT
TCGTAAAAAA
CCGCAATCAA
GCGGATTI'TA
CTCTCAAAAC
AAAAACTI'AT
GCCCTI'AAAG
TCTCCAA
INFORMATION FOR SEQ ID NO:381: SEQUENCE
CHARACTERISTICS:
LENGTH: 627 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc~feature LOCATION .627 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:381
ATGAATGCAT
ASCCCARYGA
AAAAACCGGA
GTAGCGTATG
ATCATGTGGC
GTGATI'GGGG
CCCATI'GTGG
AAAGGCGAAA
TrATTAGATG
AATAAAGCGC
TCAAGCGCGC
TGAAGCGTGC
GTGTTTAAGA
GCGACGC'TT
CACACGGAGC
TTGA)).ATTA
CGAACAACGC
TGGGCGATGT
GGTTGGCACA
ATTTTGGTAA,
GGACATI'CCT
GGGTGATCGC
TCCGA'TIC
CT'GATG'NAA
GGATITGAAA,
TCACGCTGAA
CGATAAGGTG
AAGTCAGGGC
TT'CTGGGCGT
GTAAATITIT
GGGCCGGCGA
TAAGGCTACA
CTTTIGCC
TI'GATGGGCG
GATATTCCTT
ATTGAAGCCA
GGAAGCTCTA
TTTGTGCCTA.
'rI GCGACTT
GAGGGCGATA
GTTAGCACCT
ATCCCCTrAA
ATCGGAAGCG
AAACCAATAC
TACACGCCAA
TTAAAACTAA
GAAAAAGCGC
ATAAAAGGAG
GTGAAGATAG
TCATIAAAAT
TI'AAGCTAGA
TCATTGGTAG
TTCAAAAAAC
CGATGATTTA
AGCCATGCTA
AGGCGTCCT
GACTAACTCT
TGGAGGCATIT
CGGGGCGT'A.
CTACCCTTAT
GCCTG.AAACT
GGGT1'TGACC
CI'CCGCCCC
120 180 240 300 360 420 480 540 600 627 INFORMATION FOR SEQ ID NO:382: SEQUENCE CHARACTERISTICS: LENGTH: 702 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO PPT19§ 9_6 0 9,1 2 320 (iv) ANTI-SENSE:
NO
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscjfeature LOCATION .702 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:382
ATGCTTTCAG
GAGCATAACG
CAAGGTTATG
SCCGTAGGGT
ATGTGCCAG
CCAAGCGGGC
q71TGCAATGG
GATGTGGGCA
ATGGGGTTGC
TTAGTAGAAG
ATI'GATGAAA
AACCACACT
CCCACCAACC
CCTATGCGAG
AGGGAATGGA
TAAGcCATA.A
GCTTGCTCAT
CTATGGTGAG
GAAAGATCAA
CTTGCACTT'
ATGTGGCCAA
AGAGCGCTAA
AAAGCATI'CT
TGCA'ITTGAT
TTTTAAAAAT
CGTCGCTAGT
A~TGAGCTI'G
TGTTTI GAC
AGGAGCGTTA
CGGGATAGAA
CAGAGAAGAG
TTATGGCACG
TI'CTAGCT
AAGATrAGCG TAACGcTCI'
CGCTATCGCA
TACCCTGATC
GGGGTGCCAG
TTTAGTAGAG
CGGGCG7ITI'
AGCTTTGGGA
AATTATAAAA
CTITTAAAAG
GCTAATTCTA
ATCAACCCTA
AGCGGGAAAG
ATAGGCTI'AA
GATCTI'GTGG
TGAI'AAAAA
CGATGTGTGA
ATGTGATCGC
Trr'rGGGCGT
AITTACAG
AAGCCAAAGC
TGGAAATGCA
ATCAAATGAT
ACAACCCCTT
TCCTGCCT
TGGCAACAGG
GG
AGAGTTGCAA
TGGTATCACG
ATTAAGCACC
GTGCGATAAA
CGTGTITGTG
GCGCCAAGAT
AAGCTATCAT
GATGGAGT
ACGAAAGGT
AGCCAAACTC
GGGTI'CTACT
120 180 240 300 360 420 480 540 600 660 702 INFORMATION FOR SEQ ID NO:383: SEQUENCE
CHARACTERISTICS:
LENGTH: 795 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: mfisc-feature LOCATION .795 (xi) SEQUENCE DESCRIPTION: SEQ ID, NO:383
ATGAAATITI'
CTI!CTI GCA
GGCTTTAG
AAAAAACGCT
GTGGCAGAAA
ACGCTIAG
TIGCTTTACT
AGAGCGCTTG
AGCGTTCGTA
TCTCTTTCIT
GCCATAAAAT
ACGGGCGATA
AACTCTATGG
TAAAATTCTT
ACGCTCT7C GCGC1-I717
TGAAATATC
TITTACGCT
CCACAAACAG
ACGCTTIGAT
TGCCTGGTGT
ACAI'AAACA
TAGCTAGGGG
T 'rATAGCTT
TITCAAATGT
CTATAGCGTT
TGCCAGTAGC
TAACGCTI'AC
AATcGGGTTr
AI'AGAATGG
G TTATGT
CTCTGAAACG
TTrGATCGCT
GATAGCGAGC
CCTTACAAAG
GTITTTATTCC
TTAAATAAT
CGTCT1'AGTC
CCTAATAATC
GTAACTCTAG
AAAAATAGCG
GTGGTGTATT
CTGTTTATAG
AAAATGCCTT
ATGGCGTI'IA
TTGTTGATCG
G TrTAGGGC
AACGATGCGA
GcI'ATrIGA cTTTATITrAC
ATCGCGAAAG
CCTTATSCGA
ATGAAAAATT
ATTGrrrrc
ATGGTTGCGC
GAAGCGGTAT
T=TCAAAGG
TAAAAkAGCTA
CCATTAAAAT
?ITrCTATCCT TrITTAAAAAG
GTTTGTTTGA
CAAGCGATI'A
CGCGAGCAGA
GCGAACTCGC
TTTAATGTTC
m: cTCTAAA
GCTAATCCCT
TATITI'IAGC
CTTGATrGAC
TAA.AAATTAT
CATTCGCTIr
TACAATAGG
ATcAcTCTTT
TCGCCAACAA
TCTTTCTAGC
AATTrCATGC
CAACGAGAGA
120 180 240 300 360 420 480 540 600 660 720 780 795 GAGAGAGAGA
GAGAG
2) INFORMATION FOR SEQ ID NO:384: ENOS 18 DEC 1996 321 SEQUENCE CHARACTERISTICS: LENGTH: 509 amino acids TYPE: amino acid TOPOLOGY: linear (iiy MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...509 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:384 Met Cys Ser Gin Glu Ile Leu Ser Ser Leu Gin Thr Ile Ile Ala Glu 1 5 10 Gin Phe Ser Ile Asn Ile Ile Thr Gin Leu Ala Asn Lys Leu Thr Gin 25 Val Lys Asn Leu Asn Phe Phe Glu Asn Lys Asp His Thr Ile Lys Leu 40 Asn Thr Ile His Asn Gly Leu His Ile Arg Pro Leu Asn Tyr Val Ser 55 Asn Leu Phe Phe Asn Leu Gin Arg Ile Ile Gly Leu Ile Ser Leu Phe 70 75 Gly Ile Leu Phe Ser Ile Ser Ile Tyr Leu Pro Phe Ile Met Ile Phe 90 Ala Thr Val Pro Cys Ile Leu Ile Ser Asn His Ile Ala Lys Lys His 100 105 110 Ser Ala Ser Ile Asp Lys Leu Gln Asp Gin Lys Glu Ser Met Gin Asn 115 120 125 Tyr Leu Tyr Ser Gly Leu Asp Asn Gin Lys Asn Lys Asp Asn Leu Leu 130 135 140 Phe Asn Phe Met Leu Asn Phe His His Lys Phe Ile Glu Thr Lys Glu 145 150 155 160 Leu Tyr Leu Asn Asn Phe Val Lys Val Ala Gin Lys Asn Leu Ile Phe 165 170 175 Thr Ile Tyr Ala Asp Val Leu Ile Thr Thr Leu Ser Ile Ala Leu Phe 180 185 190 Phe Leu Met Val Phe Ile Ile Leu Ser Lys Leu Ile Gly Val Gly Ala 195 200 205 lie Ala Gly Tyr Ile Gin Ala Phe Ser Ser Thr Gin Gln Gin Leu Gin 210 215 220 Asp Leu Ser Phe Tyr Gly Lys Trp Phe Phe Ala Ile Asn Lys Tyr Phe 225 230 235 240 Glu Asn Tyr Phe Cys lie Leu Asp Tyr Lys Ile Pro Lys Pro Glu Thr 245 250 255 Gin Ile Lys Leu Glu Glu Lys Ile His Ser Ile Thr Phe Glu Asn Ile 260 265 270 Ser Phe Ser Tyr Pro Asn Ser Lys Leu Ile Phe Giu Asn Phe Asn Leu 275 280 285 Ser Leu His Ser Asn Lys Ile Tyr Ala Leu Val Gly Lys Asn Ala Ser 290 295 300 Gly Lys Ser Thr Leu Ile Asn Leu Leu Leu Gly Phe Tyr Thr Pro Asn 305 310 315 320 Ser Gly Gin Ile Ile Ile Asn Asn Lys Tyr Pro Leu Gin Asp Leu Glu 325 330 335 Leu Asn Ser Tyr His Gin Gin Met Ser Ala Ile Phe Gin Asp Phe Ser 340 345 350 Leu Tyr Ala Gly Tyr Ser Ile Asp Asp Asn Leu Phe Met Gin Asn Asn Al5 360 365 P~~f~~96/U9 12.2 Ile Asp 385 Gly Ile Asp Asp His 465 Gin Gin Leu Asn 390 Gly Ala Ala Lys Val 470 Glu Glu Lys 375 Cys Val Phe Ile Ser 455 Lys Gin Leu Lys Asn Phe Lys 425 Pro Ser Ala Asn Leu 505 Arg Asp Ser 410 Pro Ile Lys Asn Phe 490 Lys 322 Glu Ile 380 Cys Asn 395 Leu Gly Ser Asn Met Glu Met Ala 460 Glu Ile 475 Glu Thr Gin Gin Leu Asn Gin Cys Lys 445 Leu Ile Leu Tyr Lys Thr Lys Ile 430 Glu Ile Val Met Ser Leu Gin 415 Val Phe Ile Leu Lys 495 INFORMATION FOR SEQ ID NO:385: SEQUENCE CHARACTERISTICS: LENGTH: 172 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...172 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:385 Met Lys Gly Pro Ile Leu Trp Pro Ala Phe Ser Gln Phe Ser Asp Gin 1 Asp Leu Leu Ser Leu Asp Asn Tyr Lys Gly Leu Pro Lys Gin Glu Arg 130 Ser Phe 145 Lys Phe Ser Asp Tyr Leu Glu Gly Val 115 Asn Leu Lys Asp Lys Ala Gly His Thr 100 Ile Thr Ala Lys 5 Ile Glu Lys Ser Gly Ala Ser Leu Tyr Gly 165 Val Val Asp His 70 Leu Met Tyr Gly Ala 150 Gly Ala Phe Lys 55 Ala Asn Pro Leu Ile 135 Gly Thr Tyr Ala 40 Ala Pro Val Arg Glu 120 Lys Lys Trp Leu 25 Gin Phe Asp Phe Val 105 Lys Ile Glu 10U Thr Ser Ser Leu Ile 90 Gly Ala Met Lys Ser Cys Asp Ser 75 Asn Leu Gly Ile Phe 155 Ile Gin Pro Met Asp Asn Asp Phe 140 Gly Leu Arg Lys Met Pro Glu Arg 125 Phe Ala Pro Cys Asp Ile Gin Lys 110 Lys Ala Lys Lys His Leu Arg Lys Ala Lys Val Cys Asn Ser Ala Ala Leu Gin His Leu Ile 160 Phe Tyr Asp Phe 170 INFORMATION FOR SEQ ID NO:385: 323 SEQUENCE CHARACTERISTICS: LENGTH: 172 amino acids TYPE: amino acid TOPOLOGY: linear (ii)-MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...172 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:385 Met Lys Gly Pro Ile Leu Trp Pro Ala Phe Ser Gln Phe Ser Asp Gin 1 5 10 Asp Leu Ser Asp Ile Val Ala Tyr Leu Thr Ser Ile Leu Pro Lys Asn 25 Leu Ser Asp Lys Glu Val Phe Ala Gln Ser Cys Gln Arg Cys His Ser 40 Leu Asp Tyr Ala Lys Asp Lys Ala Phe Ser Asp Pro Lys Asp Leu Ala 55 Asn Tyr Leu Gly Ser His Ala Pro Asp Leu Ser Met Met Ile Arg Ala 70 75 Lys Gly Glu His Gly Leu Asn Val Phe Ile Asn Asp Pro Gln Lys Leu 90 Leu Pro Gly Thr Ala Met Pro Arg Val Gly Leu Asn Glu Lys Ala Gin 100 105 110 Lys Gln Val Ile Ser Tyr Leu Glu Lys Ala Gly Asp Arg Lys Lys His 115 120 125 Glu Arg Asn Thr Leu Gly Ile Lys Ile Met Ile Phe Phe Ala Val Leu 130 135 140 Ser Phe Leu Ala Tyr Ala Gly Lys Glu Lys Phe Gly Ala Lys Cys Ile 145 150 155 160 Lys Phe Lys Lys Gly Gly Thr Trp Phe Tyr Asp Phe 165 170 INFORMATION FOR SEQ ID NO:386: SEQUENCE CHARACTERISTICS: LENGTH: 133 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_ feature LOCATION 1...133 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:386 Met Glu Arg Lys Thr Leu Gln Ser Ile Leu Cys Leu Ile Lys Lys Glu 10 P.G.Tus 960U9122 us 1 i 18 Q r'c 1
I~%
Met His Ilie Ilie Gly G ly Arg Leu Met Gin Ser s0 Leu Val1 Ile Lys Ser 130 Arg Val1 Ser G-1u Ile Leu Vai 115 Ser Pro Leu Thr Ala Aia Aia 100 Tyr Lys Leu Thr 40 Ile Leu Ser Aia Val1 120 Met 25 Thr Giy dly Lys Tyr 105 Tyr 324 Cys C) Leu Vi Phe Ga: Leu G 75 Lou I~ Phe T1 Gin M, Arg Vali Thr Gin Aia Leu Gin 125 Thr Leu Val1 Ala Thr Ile 110 Val1 Lys Ile Giu Phe Ala Lys Ile INFORMATION FOR SEQ ID NO:387: SEQUENCE CHARACTERISTICS: LENGTH: 158 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc..feature LOCATION .158 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:387 Met His Giu Arg Ile Giu Arg Gly Ile Unk Asn Asn Giu Cys Lys Glu in 1s Ile Ile Gly Ile Asn Gly Ile Ser Asp 145 Phe G iu Lys Ile Met Leu Aia Phe 130 Lys Gly Asn Giu Leu Lys Gin Arg Lys Thr Lys Leu Ile Giu Asp Arg Asn Lys Asp .Val1 Giy 115 Phe Asn Arg Ile Arg Ser Leu 100 Val1 Asp Leu Ph.
Glu Ile Gly Leu Giy Ser His Lys Gin Asn 70 Ile Leu Leu Asp Gin 150 Glu Leu 55 Asn Asp Leu Ala Tyr 135 Ile Cys 40 G iu Lou Thr Thr Lou 120 Lys Cys Giu Giu Gly Ile Pro 105 Val1 Lys Glu Giu Arg Leu Gly 90 Val1 G ly Ser Lys Gin Val1 Asn 75 Lou Val Val1 Gin Leu 155 Ph.
Lys Pro Ph.
Giy Gly Gin 140 Cys Arg Asp Asn Ser Glu Lys 125 Arg Arg Gly Ser Ser Ser Phe 110 Ser Lys Met Sen Vai Lou Ala Asn Phe Ile Gly Ala Lou Ile Trp Glu Val INFORM4ATION FOR SEQ ID NO:388: SEQUENCE CHARACTERISTICS: LENGTH: i12 amino acids TYPE: amino acid PCT/US 9 6/0912 IPEA/US i DEC 1995 325 TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...112 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:388 Met Pro Gly Val Tyr Gln Met Ser Ile Glu Pro Leu Leu Lys Glu Cys 1 5 10 Glu Glu Leu Val Gly Leu Gly Ile Lys Ala Val Leu Leu Phe Gly Ile 25 Pro Lys His Lys Asp Ala Thr Gly Ser His Ala Leu Asn Lys Asp His 40 Ile Val Ala Lys Ala Thr Arg Glu Ile Lys Lys Arg Phe Lys Asp Leu 55 Ile Val Ile Ala Asp Leu Cys Phe Cys Glu Tyr Thr Asp His Gly His 70 75 Cys Gly Ile Leu Glu Asn Ala Ser Val Ser Asn Asp Lys Thr Leu Lys 90 Ile Leu Asn Leu Gln Gly Leu Ile Leu Leu Lys Ala Val Trp Ile Phe 100 105 110 INFORMATION FOR SEQ ID NO:389: SEQUENCE
CHARACTERISTICS:
LENGTH: 65 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...65 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:389 Val Glu Asn Asn Lys Ser Leu Lys His Ala Asn Glu Leu Arg Asp Lys 1 5 10 is Arg Asp Glu Leu Glu Phe His Leu Arg Glu Leu Phe Gly Gly Asn Val 25 Phe Lys Ser Ser Ile Lys Thr His Ser Leu Thr Asp Lys Asp Ser Ala 40 Asp Phe Asp Glu Ser Tyr Asn Leu Asn Ile Gly His Gly Unk Asn Unk 55 Ile 2) INFORMATION FOR SEQ ID NO:390: rCT/US 9 6 U9 Z 2 326 SEQUENCE
CHARACTERISTICS:
LENGTH: 61 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...61 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:390 Met Gln Glu Phe Ser Leu Trp Cys Asp Phe Ile Glu Arg Asp Phe Leu 1 5 10 Glu Asn Asp Phe Leu Lys Leu Ile Asn Lys Gly Ala Ile Cys Gly Unk 25 Thr Ser Asn Pro Ser Leu Phe Cys Glu Ala Ile Thr Lys Ser Ala Phe 40 Tyr Gln Asp Glu Ile Ala Lys Unk Gln Arg Gln Lys Ser 55 INFORMATION FOR SEQ ID NO:390: SEQUENCE
CHARACTERISTICS:
LENGTH: 61 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc.feature LOCATION 1...61 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:390 Met Gln Glu Phe Ser Leu Trp Cys Asp Phe Ile Glu Arg Asp Phe Leu 1 5 10 Glu Asn Asp Phe Leu Lys Leu Ile Asn Lys Gly Ala Ile Cys Gly Unk 25 Thr Ser Asn Pro Ser Leu Phe Cys Glu Ala Ile Thr Lys Ser Ala Phe 40 Tyr Gln Asp Glu Ile Ala Lys Unk Gin Arg Gin Lys Ser 55 INFORMATION FOR SEQ ID NO:391: SEQUENCE CHARACTERISTICS: LENGTH: 619 amino acids TYPE: amino acid TOPOLOGY: linear PCT/US 9 6 9 1 2 2 IPENUS 18 DEC 1996 327 (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...619 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:391 Val Phe Val Ala Ser Lys Gln Ala Asp Glu Gln Lys Lys Leu Val Ile 1 5 10 Glu Gin Glu Val Gin Lys Arg Gin Phe Gin Lys Ile Glu Glu Leu Lys 25 Ala Asp Met Gin Lys Gly Val Asn Pro Phe Phe Lys Val Leu Phe Asp 40 Gly Gly Asn Arg Leu Phe Gly Phe Pro Glu Thr Phe Ile Tyr Ser Ser 55 Ile Phe Ile Leu Phe Val Thr Ile Val Leu Ser Val Ile Leu Phe Gin 70 75 Ala Tyr Glu Pro Val Leu Ile Val Ala Ile Val Ile Val Leu Val Ala 90 Leu Gly Phe Lys Lys Asp Tyr Arg Leu Tyr Gln Arg Met Glu Arg Ala 100 105 110 Met Lys Phe Lys Lys Pro Phe Leu Phe Lys Gly Val Lys Asn Lys Ala 115 120 125 Phe Met Ser Ile Phe Ser Met Lys Pro Ser Lys Glu Met Ala Asn Asp 130 135 140 Ile His Leu Asn Pro Asn Arg Glu Asp Arg Leu Val Ser Ala Ala Asn 145 150 155 160 Ser Tyr Leu Ala Asn Asn Tyr Glu Cys Phe Leu Asp Asp Gly Val Ile 165 170 175 Leu Thr Asn Asn Tyr Ser Leu Leu Gly Thr Ile Lys Leu Gly Gly Ile 180 185 190 Asp Phe Leu Thr Thr Ser Lys Lys Asp Leu Ile Glu Leu His Ala Ser 195 200 205 Ile Tyr Ser Val Phe Arg Asn Phe Val Thr Pro Glu Phe Lys Phe Tyr 210 215 220 Phe His Thr Val Lys Lys Lys Ile Val Ile Asp Glu Thr Asn Arg Asp 225 230 235 240 Tyr Gly Leu Ile Phe Ser Asn Asp Phe Met Arg Ala Tyr Asn Glu Lys 245 250 255 Gin Lys Arg Glu Ser Phe Tyr Asp Ile Ser Phe Tyr Leu Thr Ile Glu 260 265 270 Gin Asp Leu Leu Asp Thr Leu Asn Glu Pro Val Met Asn Lys Lys His 275 280 285 Phe Ala Asp Asn Asn Phe Glu Glu Phe Gin Arg Ile Ile Arg Ala Lys 290 295 300 Leu Glu Asn Phe Lys Asp Arg Ile Glu Leu Ile Glu Glu Leu Leu Ser 305 310 315 320 Lys Tyr His Pro Thr Arg Leu Lys Glu Tyr Thr Lys Asp Gly Ile Ile 325 330 335 Tyr Ser Lys Gin Cys Glu Phe Tyr Asn Phe Leu Val Gly Met Asn Glu 340 345 350 Ala Pro Phe Ile Cys Asn Arg Lys Asp Leu Tyr Leu Lys Glu Lys Met 355 360 365 His Gly Gly Val Lys Glu Val Tyr Phe Ala Asn Lys His Gly Lys Ile 370 375 380 Leu Asn Asp Asp Leu Ser Glu Lys Tyr Phe Ser Ala Ile Glu Ile Ser .385 390 395 400 lu Tyr Ala Pro Lys Ser Gin Ser Asp Leu Phe Asp Lys Ile Asn Ala N 405 410 415 PE~iUS~ JJG1996 329 Leu Asp Ser Giu Phe Ile Phe Met His Ala Tyr Ser Pro Lys Asn Ser 420 425 430 Gin Val Lou Lys Asp Lys Leu Ala Phe Thr Ser Arg Arg Ile Ile Ile 435 440 445 Ser Gly Gly Ser Lys Glu Gin Gly Met Thr Lou Gly Cys Leu Ser Glu 450 455 460 Leu Val Gly Asn Gly Asp Ile Thr Leu Gly Ser Tyr Gly Asn Ser Leu 465 470 475 480 Val Leu Phe Ala Asp Ser Phe Glu Lys Met Lys Gin Ser Val Lys Glu 485 490 495 Cys Val Ser Ser Lou Asn Ala Lys Giy Phe Leu Ala Asn Ala Ala Thr 500 505 510 Phe Ser Met Giu Asn Tyr Phe Ph. Ala Lys His Cys Ser Phe Ile Thr 515 520 525 Lou Pro Phe Ile Phe Asp Val Thr Ser Asn Asn Phe Ala Asp Phe Ile 530 535 540 Ala Met Arg Ala Met Ser Phe Asp Gly Lys Giu Asp Asn Asn Ala Trp 545 550 555 560 Gly Asn Ser Val Met Thr Lou Lys Ser Glu Ile Asn Ser Pro Ph. Tyr 565 570 575 Leu Asn Phe His Met Pro Thr Asp Phe Gly Ser Ala Ser Ala Gly His 580 585 590 Thr Leu Ilie Leu Giy Ser Thr Gly Ser Gly Lys Asn Ser Val Tyr Val 595 600 605 His Asp Ser Lys Arg Tyr Gly Ala Ile Cys Leu 610 615 INFORMATION FOR SEQ ID NO:392: SEQUENCE CHARACTERISTICS: LENGTH: 110 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .110 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:392 Val Lys Thr Ser Cys Lou Val. Thr Ilie Gly Arg Ile Arg Gly Val. Ph.
1 5 10 Ile Ile Lys Ala Gin Lou Leu Leu Arg Glu Gly Gly Ph. Met Asn Ph.
25 Thr Ala Tyr Asn Thr Lys Thr Pro Gly His Leu His Leu Tyr Val. His 40 Lys Gly His Thr Giu Lou Gly Giu Giy Giu Arg Leu Ile Lys Thr Leu s0 55 Ser Met Lys Lou Ala Gin Gly Lou Pro Lys Giu Trp Arg Val Ph. Pro 70 75 Ser Asn Giu Trp Pro Lys Giu Phe Asn Ile Lou Ala Lou Pro Tyr Glu 90 Val Phe Ala Lys Giu Arg Gly Ser Ser Trp Ala Lys His Lou 100 105 110 )INFORMATION FOR SEQ ID NO:393: PEA/US 18 DEC 1996 329 SEQUENCE
CHARACTERISTICS:
LENGTH: 68 amino acids TYPE: amino acid TOPOLOGY: linear (ii)-MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...68 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:393 Val Ala Lys Asp Ile Ile Ser Giu Ser Gin Asn Leu Cys Ala Arg Lys 1 5 10 Phe Arg Arg Leu Tyr Ala Leu Leu vs Glu Asn Glu Met Leu Ile Arg 3 Ile Gly Ser Tyr Gln Met Gly Asn Asp Lys Glu Leu Asp Glu Ala Ile 40 Lys Lys Lys Ala Leu Met Glu Gln Phe Leu Val Gln Asp Glu Asn Ala 55 Leu Unk Ala Phe INFORMATION FOR SEQ ID NO:394: SEQUENCE CHARACTERISTICS: LENGTH: 446 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...446 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:394 Met Lys Ser Arg Pro Ile Leu Ala Gin Ala Tyr Ala Leu Gin Met Met 1 5 10 Val Lys Gln Ile Ala Phe Leu Glu Thr Ile Leu Val Glu Asn Glu Gin 25 Asp Ala Leu Ile Leu Giu Asn Ser Leu Ile Lys Gin Leu Lys Pro Lys 40 Tyr Asn Ile Leu Leu Arg Asp Asp Lys Thr Tyr Pro Tyr Ile Tyr Met 55 Asp Phe Ser lie Asp Phe Pro Ile Pro Leu Ile Thr Arg Lys Ile Leu 70 75 Lys Gln Pro Gly Val Lys Tyr Phe Gly Pro Phe Thr Ser Gly Ala Lys 90 \Asp Ile Leu Asp Ser Leu Tyr Glu Leu Leu Pro Leu Val Gin Lys Lys Y 100 105 110 PCT/US 96/09122 IPEA/US 18 DEC 1996 'a Lts Lvs Ala Cys Met Phe Tyr Gln Ile Glu Arg Asn Cys Ile Lys 115 p 120 Cys Ile 145 Lys Gu Ala Phe Met 225 Leu His Ala Gin Leu 305 Gin Leu Ser Asn Ser 385 Asp Arg Phe Lys 130 Ala Glu Glu Pro Ala 210 Arg Asn Tyr Cys Tyr 290 Ala Glu Phe His Asn 370 Asn Phe Ala Val Ala Lys Leu Ala Phe 195 Phe Gly Gly Gin Ser 275 Ser Leu Lys Asn His 355 Ala Glu Ala Gin Glu 435 Pro 3lu Glu Leu 180 Thr Tyr Gly Phe Ser 260 Asn Lys Ile Thr Leu 340 Ser Phe Tyr Lys Leu 420 Val Cys Cys Leu 165 Ile Cys Gly Lys Asp 245 His Glu Lys Glu Ser 325 Glu Asn Gin Asp Glu 405 Asn Glu Leu 150 Lys Tyr Met Gly Ile 230 Thr Leu Thr Ile Ile 310 Asn Cys Ser Lys Gin 390 Pro Ile Asp 135 Glu Met Arg Asp Asn 215 Ile Asp Pro Leu Ala 295 Ala Glu Val Gin Asp 375 Met Pro Ala Lys Ile Met Ile Glu Arg Asp Arg 185 Leu Ala 200 Asn Lys Ser Ser Glu Ala Leu Met 265 Lys Glu 280 Leu Ser Met Lys Asp Arg Pro Tyr 345 Cys Val 360 Ser Tyr Ser Glu Pro Asn Leu Glu 425 Thr Glu Leu 170 Ile Lys Ala Ala Met 250 Pro Leu Ile Asn Ile 330 Arg Gly Arg Leu Leu 410 Ile Lys Asn 155 Ser Ala Leu Val Phe 235 Lys Glu Gin Pro Ala 315 Leu Val Gly Arg Leu 395 Trp Glu 140 Lys Ser Lys Tyr Leu 220 Glu Gin Gin Glu Lys 300 Gin Glu Glu Met Tyr 380 Thr Val 125 Glu Asp Asn Ile Asp 205 Val Lys Ala Ile Phe 285 Lys Glu Glu Ile Val 365 His Arg Ile Tyr Arg Leu Gln 190 Leu Lys Ile Ile Leu 270 Ile Gly Ile Ala Phe 350 Val Leu Arg Asp Leu Leu Arg 175 Lys Asp Met His Ile 255 Leu Ser Asp Phe Arg 335 Asp Tyr Lys Ala Gly 415 Lys Ile 160 Phe Ile Ile Phe Ser 240 Asn Ser His Lys Ser 320 Ser Thr Glu Gly Leu 400 Gly Leu Lys Ser Ser Gly Ser Ile Ala Ile Ser 440 Lys Glu Lys Arg Gly Phe 445 INFORMATION FOR SEQ ID NO:395: SEQUENCE CHARACTERISTICS: LENGTH: 84 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...84 S (xi) SEQUENCE DESCRIPTION: SEQ ID NO:395 Sal Ser Leu Gly Ala Phe Gln Gly Tyr Tyr Gly Gly Leu Val Asp Leu IPEA/US 18 L'99 331 1 5 10 Val Gly Gln Arg Leu Ser Glu Ile Trp Ser Ala Ile Pro Met Leu Phe 25 Leu Leu Ile Val Ile Ser Ser Ala Phe Asn Ser Asn Phe Trp Ile Ile 40 Leu Phe Leu Val Leu Leu Phe Ser Trp Met Gly Leu Ser Gln Val Val 55 Arg Thr Glu Phe Leu Lys Ala Arg Asn Met Asp Tyr Thr Lys Ala Ala 70 75 Arg Ala Leu Gly INFORMATION FOR SEQ ID NO:396: SEQUENCE CHARACTERISTICS: LENGTH: 40 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION 1...40 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:396 Met Ser Glu Ala Tyr Phe Leu His His Lys Asn Ala Ser Gln Val Ser 1 5 10 Leu Asn Glu Gln Val Leu Asn Val Met Lys Gln Val Gln Leu Asp Glu 25 Asn Phe Trp Asn Val Ser Leu Met INFORMATION FOR SEQ ID NO:397: SEQUENCE CHARACTERISTICS: LENGTH: 300 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...300 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:397 Val Ile Leu Ile Phe Ile Ile Val Val Glu Asp Gln Lys Gly Ile Phe 1 5 10
I
5 SPro Ile Ala Ala Ser Lys Arg Lys Ser Gin Ser Ser Val Ile Ile Glu 25 PCT/US 96/0912 2 PEA/US 18 DEC 1996 Asp Val Glu Gly Gly His Glu Asn Phe Leu Thr Gly Ala Tyr 130 Leu Leu 145 Lys Asn Met Glu Leu Thr Lys Glu 210 Glu Leu 225 Cys His Ile Ala Ser Lys Phe Phe 290 Cys Leu Ala Glu Met Arg 115 Lys Asn Leu Cys Pro 195 Arg Leu Met Leu Ile 275 Lys Phe Ser Leu Lys Leu Ser Ala Glu Val Ser 100 Met Val Ile His Pro Asp Lys Ser 165 Gly Phe 180 Arg Gin Val Ser Lys Glu Cys Ser 245 Asn His 260 Leu Lys Unk Arg Lys Lys Gly 70 Arg Lys Ala Lys Val 150 Ile Cys Arg His Ser 230 Thr Tyr Ser Phe Glu His 55 Asn Lys Ser Pro Gin 135 Ile Tyr Glu Ile Gly 215 Glu Leu Gin His Arg 295 Asp 40 Gly Leu Ala Ser Phe 120 Ile Ile Pro Arg Val 200 His Tyr Cys Lys Ala 280 Gly Phe Phe His Phe Gly 105 Val Lys Thr Ile Ile 185 Ile Asp Leu Pro Asn 265 Asn Phe Val Lys Phe Giu 90 Ser Glu Glu Asn Glu 170 Cys His Glu Ala Leu 250 Pro Asp Glu Asp Val 75 Asn Ile Met Leu Asp 155 Glu Pro Arg Asp His 235 Gly Lys His Gly Asn Val Leu Lys Glu Phe 140 Lys His Ser Glu Gin 220 Ala Ile Gly Lys Ala Gly Thr Val Ala Trp 125 Asp Glu Leu Lys Val 205 Val Thr Asp Glu Arg 285 Lys Ile Pro Ser Glu 110 Gly Pro Ile Asp Asp 190 Glu Leu Cys Thr Lys 270 Gly Ala Ile Ile Glu His Glu Asn His Met 175 Leu Arg Leu Ala Gly 255 Ile Ser Ile Phe Leu Met Gly Lys Gly Thr 160 Cys Ser Leu Asp Val 240 Unk Ala Phe Lys Asn Ser 300 INFORMATION FOR SEQ ID NO:398: SEQUENCE CHARACTERISTICS: LENGTH: 214 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...214 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:398 Met Lys Glu Lys Asn Phe Trp Pro Leu Gly Ile Met Ser Val Leu Ile 1 5 10 Phe Gly Leu Gly Ile Val Val Phe Leu Val Val Phe Ala Leu Lys Asn 25 Ser Pro Lys Asn Asp Leu Val Tyr Phe Lys Gly His Asn Glu Val Asp 40 Leu Asn Phe Asn Ala Met Leu Lys Thr Tyr Glu Asn Phe Lys Ser Asn 55 \Tyr Arg Phe Ser Val Gly Leu Lys Pro Leu Thr Glu Ser Pro Lys Thr FibS 9 6O92~ 'FNUS 18 DEC 1996 Pro Gin Leu Ile Leu 145 Leu Val1 Ser Phe Ile Giu Tyr Gin 130 Giy Leu Phe Ser Phe 210 Leu As n Ala 115 Vali Thr Giu Lys Met 195 Lys Pro Leu 100 Gin Tyr Leu Gly As n 180 Ala Tyr Tyr Leu Leu Leu Asp Asp 165 Lys Cys Lys 70 Phe As n Gin Ala Cys 150 Lys Giu Met Ile Ser As n Pro Phe 135 Lys Val1 Giu Gly Lys Ala Leu 120 Tyr As n Gly Leu Ile 200 Gly Leu 105 Lys Pro Ala Arg Ile 185 Ser Gly Giu Leu Ser 140 Pro Ile Gin Lys Asp Lys Asp 125 Gin Leu Leu Leu Asn 205 Lys Ser 110 Ser Prb Lys Phe Leu 190 Ala Ile Thr Asn Leu Asp 160 Phe Leu Ala INFORMATION FOR SEQ ID NO:399: SEQUENCE CHARACTERISTICS: LENGTH: 137 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION .137 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:399 Met Leu Met Leu Lys Leu Phe Lys Arg Pro Ilie Lys Gly Ser Phe Leu Ala Arg Asn Arg Leu Vai Thr Ser Pro s0 Gly Leu Leu Phe Ilie 130 Asp Ser Gin Gin Lys Giu Gly 115 As n Ala Ala Arg Ala Asp Tyr 100 Asp His Ile Leu Asn Gly 70 His Ala Leu Vali Ile Ala Giu 55 Ile Leu Lys Leu Val1 135 Pro Gin 40 Ser Phe Lys Asn Glu 120 Leu Gin 25 Lys Asp Asn Glu Pro 105 Tyr Ala Ala Tyr Gly Ile Met Ser Glu Asp Gin Thr Gin 75 Pro Tyr Leu Leu Lys Asn Asn Giu Giu Leu Lys Pro Giu Phe Met Giu Gly 125 Ser Leu Leu Ile Lys Ala 110 Lys Ile is Gly Phe Leu Asn Asp Tyr Ile Ala Ser Val Giu Thr Giu Leu Lys INFORMATION FOR SEQ ID NO:400: SEQUENCE CHARACTERISTICS: It LENGTH: 272 amino acids IPENUS 18 DEC 1996 334 TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...272 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:400 Met Val Val Glu Leu Lys Asn Ile Glu 1 His Gly Ile Val Lys Val Thr Glu Gin 145 Leu Ile Val Met Glu 225 Ile Val Ala Val Asn Asn Ile Phe Lys Asp 130 Arg Cys Leu Phe Cys 210 Ile Lys Phe Leu Ile Cys Leu Gly Glu Ile 115 Lys Val Asp Thr Ile 195 Val Phe Asn Leu Lys Gly Leu Leu Met Asn 100 Lys Val Ala Glu Leu 180 Thr Ile Ala Glu Gly 260 5 Gly Tyr Glu Asn Ile Val Ser His Ile Ala 165 Leu His Ser Asn His 245 Glu Val Ser Arg Leu 70 Phe Ala Arg Phe Ala 150 Thr Ser Gin Ser Pro 230 Ala His Asn Gly Pro 55 Lys Gin Phe Val Tyr 135 Arg Ser Gly Ile Gly 215 Lys Asp Leu Ala 40 Ser Pro His Ala His 120 Pro Ser Ala Ile Glu 200 Glu His Gin Glu 25 Gly Ser Lys Phe Leu 105 Glu Lys Leu Leu Gin 185 Val Ile Ala Lys Lys 10 Leu Lys Gly Glu Asn 90 Glu Leu Gin Ala Asp 170 Lys Val Val Val Ser 250 Ile Tyr Glu Lys Lys Gly Ser Thr Leu Glu Val Leu Leu Gln Lys 75 Leu Leu Ser Ile Ala Arg Leu Glu Leu 125 Leu Ser Gly 140 Asn Cys Pro 155 Ser Lys Thr Lys Phe Asp Lys Glu Leu 205 Glu Arg Gly 220 Thr Lys Glu 235 Gin Asp Ile Asn Asp Ile Val Ala Ala Trp 110 Val Gly Asn Thr Leu 190 Cys Ser Leu Tyr Gly Ile Arg Asn Arg Lys Glu Gly Gin Leu His 175 Ser Asn Val Leu Arg 255 Phe Leu Leu Gly Gin Asn Lys Leu Lys Leu 160 Ser Ile Gin Glu Gly 240 Ile Leu Asp Glu Pro Ile Ile Ser Unk Phe Unk 265 270 INFORMATION FOR SEQ ID NO:401: SEQUENCE CHARACTERISTICS: LENGTH: 286 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori 9 6 0 9 12 P9WUS 18 DEC 1996 335 (ix) FEATURE: NAME/KEY: misc_feature LOCATION .286 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:401 Leu Unk-Pro Met Lys Val Ile Gin Vai Phe Leu Phe 1 Cys His Ala Ser Tyr Leu Aia Ilie Ilie 145 Pro Leu Tyr Giu Val1 225 Thr Val1 Phe Val1 Giu Arg Ala Lys Phe 100 Ala Asn Lys Ile Thr 180 Leu Asp Asp Asp Asn 260 Gly 5 Pro Arg Val1 Ile Asp Leu Ile Unk Asn Gly 165 Gin Met Arg Ile Arg 245 Val1 Asp As n Phe Ile Val1 70 O iy Val1 Leu Leu As n 150 Unk Giu Asp Leu Asp 230 Val1 Val1 Ile Giu Asp Lys Thr G ly Asp O iy Ile Ser 170 Val1 Giu Pro His Gly 250 Giu Leu His Lys Pro Asp Ser Giu Giu Ile Asp 155 Ala Ile Phe Val1 Phe 235 Asp Lys Arg Leu Tyr Phe Ile Phe His Leu Lys 140 Asp Arg Trp Lys Tyr 220 Lys Phe Gly Gly Ser Giu Phe Leu Tyr Giu As n As n 125 Lys Tyr Ile Gin Lys 205 Ser His Leu Phe Glu 285 INFORMATION FOR SEQ ID NO:401: SEQUENCE CHARACTERISTICS: LENGTH: 286 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-.feature LOCATION .286 IN (xi) SEQUENCE DESCRIPTION: SEQ ID p s 9D6/E1929 'IFEJS 8 DEC 199& Leu 1 Cys His Ala Ser Tyr Leu Ala Ile Ile 145 Pro Leu Tyr Glu Val 225 Thr Val Phe Unk Ala Asp Gin Lys Ile Gly Ser Arg 130 Leu Thr Leu Ser His 210 Lys Phe Asn Gly Pro Ile Leu Lys Asp Leu Ala Leu 115 Asn Gin Glu Asn Arg 195 Cys Arg Ile Asp Ala 275 Met Val Glu Arg Ala Lys Phe 100 Ala Asn Lys Ile Thr 180 Leu Asp Asp Asp Asn 260 Gly Lys 5 Pro Arg Val Ile Asp Leu Ile Unk Asn Gly 165 Gin Met Arg Ile Arg 245 Val Asp Val Asn Phe Ile Val 70 Gly Val Leu Leu Asn 150 Unk Glu Asp Leu Asp 230 Val Val Ile Ile Thr Phe Tyr 55 Leu Glu Trp Ser Asn 135 Leu Thr Lys Asn Ile 215 Leu Arg Glu Thr Gin Val Glu Pro 25 Phe Ala 40 Lys Glu Glu Lys Pro Tyr Gly Leu 105 Ala Leu 120 Phe Lys Ile Leu Leu Lys Ile Ile 185 Leu Glu 200 Ile Leu Lys Ala Lys Lys Thr Ile 265 Tyr Gin 280 Phe 10 Glu Tyr Asp Lys Thr 90 Gly Asp Gly Ile Ser 170 Va 1 Glu Pro His Gly 250 Glu Leu Leu His Lys Pro Asp 75 Ser Glu Glu Ile Asp 155 Ala Ile Phe Val Phe 235 Asp Lys Arg Phe Ser Leu Glu Tyr Phe Phe Leu Ile Tyr Phe -ilu His Asn Leu Asn 125 Lys Lys 140 Asp Tyr Arg Ile Trp Gin Lys Lys 205 Tyr Ser 220 Lys His Phe Leu Gly Phe Gly Glu 285 Asn His Leu Lys Asn Leu Ala 110 Leu Arg Ala Tyr Ala 190 Cys Ala Tyr Glu Val 270 Met Pro Tyr Asp Asn Ile Lys Thr Glu Phe His Ala 175 His Phe Ser Asn Leu 255 Ile Phe Asp His Tyr Gin Asn Asn Glu Asp His 160 Asn Lys Leu Glu Pro 240 Leu Gly INFORMATION FOR SEQ ID NO:402: SEQUENCE CHARACTERISTICS: LENGTH: 106 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...106 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:402 Met Gly Ala Leu Ile Ala Met Phe Phe Leu Met Leu Ile Lys Lys Thr 1 5 10 Ile Ala Tyr Lys Glu Asp Lys Lys Ser Ala Ala Leu Lys Val Val Pro 25 Tyr Leu Val Ala Leu Met Ser Leu Ala Phe Ser Trp Tyr Leu Ile Val 40 \Lys Val Leu Lys Arg Leu Tyr Ala Val Ser Phe Glu Ile Gin Leu Ala b
U
L
IPENUS 18 DEC 1996 337 55 Cys Gly Cys Val Leu Ala Leu Leu Ile Phe Ile Leu Phe Lys Arg Phe 70 75 Val Leu Lys Lys Ala Pro Gin Leu Glu Asn Ser His Glu Ser Val Asn 90 Glu Leu Phe Asn Val Pro Leu Ile Phe Ala 100 105 INFORMATION FOR SEQ ID NO:403: SEQUENCE CHARACTERISTICS: LENGTH: 157 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...157 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:403 Met Ile Lys Arg Ile Ala Cys Ile Leu Ser Leu Ser Ala Ser Leu Ala 1 5 10 Leu Ala Gly Glu Val Asn Gly Phe Phe Met Gly Ala Gly Tyr Gin Gin 25 Gly Arg Tyr Gly Pro Tyr Asn Ser Asn Tyr Ser Asp Trp Arg His Gly 40 Asn Asp Leu Tyr Gly Leu Asn Phe Lys Leu Gly Phe Val Gly Phe Ala 55 Asn Lys Trp Phe Gly Ala Arg Val Tyr Gly Phe Leu Asp Trp Phe Asn 70 75 Thr Ser Gly Thr Glu His Thr Lys Thr Asn Leu Leu Thr Tyr Gly Gly 90 Gly Gly Asp Leu Ile Val Asn Leu Ile Pro Leu Asp Lys Phe Ala Leu 100 105 110 Gly Leu Ile Gly Gly Val Gin Leu Ala Gly Asn Thr Trp Met Phe Pro 115 120 125 Tyr Asp Val Asn Gin Thr Arg Phe Gin Phe Leu Trp Asn Leu Gly Gly 130 135 140 Arg Met Arg Val Gly Asp Thr Val Arg Leu Lys Arg Ala 145 150 155 INFORMATION FOR SEQ ID NO:404: SEQUENCE CHARACTERISTICS: LENGTH: 278 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES S(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori PCT/US 9 6 09 12 2 IPEA/US 18 DEC 1996 (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...278 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:404 Met Tyr Arg His Val Leu Lys Asp Phe Ser Leu Asp 1 Ser Val Leu Leu Val Leu Phe Ser Lys Lys Phe Phe His Ala Lys Ala 130 Ala Phe 145 Lys Met Asn Pro Thr Asn Asn Pro 210 Val Pro 225 Lys Gly Leu Ala Glu Glu Gin Pro Gin Lys Ile Leu Ala 115 Leu Val Thr Glu Lys 195 Thr Val Ile Arg Leu 275 Glu Val Phe Ile Leu Gly 100 Leu Trp Asp Lys Ile 180 Met His Val Ala Glu 260 Phe 5 Leu Leu Gly Asn Asp Phe Leu Leu Leu Gin 165 Lys Met Tyr Val Arg 245 Leu Glu Phe Ile Trp Pro 70 Gly Phe Asn Ile Ile 150 Glu Ala Gin Ala Ala 230 Glu Tyr Arg Asn Ile Leu 55 Ile Ser Ile Leu Ser 135 Ile Val Lys Glu Val 215 Lys His Arg Gin Leu 40 Phe Asn Leu Phe Gin 120 Ser Lys Lys Ile Ile 200 Ala Gly Asp Asp 10 Leu Ala Met Val Ala Pro Gly Val Ile Thr 90 Ser Leu 105 Gly Gin Leu Leu Arg Arg Asp Glu 170 Arg Gin 185 Pro Lys Leu Lys Thr Asp Ile Glu 250 Val Lys 265 Lys Val Lys Lys 75 Leu Phe Leu Phe Gin 155 Tyr Met Ser Phe Tyr 235 Ile Asp Ala Val Asn Lys Leu Leu Leu 140 Tyr Lys Met Asn Asp 220 Leu Ile Phe Thr Phe Ile Leu Val Gly Trp 125 Phe Thr Gin Val Val 205 Glu Ala Glu Lys Leu Ser Pro Ser Leu Leu Lys Val Ser Glu 175 Asn Val His Arg Lys 255 Glu Leu Asn Lys Leu Ala Asn Ser Leu Leu 160 Gly Ala Thr Pro Ile 240 Thr Leu Asn Ala Thr Ile Pro INFORMATION FOR SEQ ID NO:405: SEQUENCE CHARACTERISTICS: LENGTH: 120 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...120 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:405 Asn Thr Unk Pro Leu Ile Ala Thr Leu Leu Gln Ala Pro Leu His pCTIUS 96/09f1"( TPEAMU 18 ni:.e iqG Val1 Thr Pro Asp Phe Asp Lys Gly Lys Leu Ser His Pro Giy 115 Ile Pro Giu Leu Lys Lys 100 Gly Arg As n Phe Leu Lys Leu Phe G lu Arg Leu Asp 70 Gin Val1 Giu Pro Pro C iu Leu Glu Ala Lys Va 1 Gin Lys Aia Phe Leu Giu 120 Gin Ala Ile Tyr 75 Leu Asp Lys Met Giu Val1 Leu Leu INFORMATION FOR SEQ ID NO:406: SEQUENCE CHARACTERISTICS: LENGTH: 226 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc.fieature LOCATION I1.. .226 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:406 Met Giy Gin Ala Phe Phe Lys Lys Ile Val Gly Cys Phe Cys Leu Gly 1 Tyr Asn Leu Thr Gly Ile Val1 Lys Lys 145 Ala Arg Leu Leu Phe Gly Val1 Phe Gin As n Lys 130 Lys Gin Ala Ser Phe As n Asp Ile Asn Pro Phe 115 Leu Ala Lys As n Asn 195 Leu Arg Giu Gin Lys Lys 100 Ala Ilie Leu Asp Leu 180 As n 5 Ser 1.y Lys Leu Gly Se r Leu Val1 Glu Lys 165 Giu Lys Ser Arg Pro G lu 70 Trp Val1 Met Asp Lys 150 Arg As n As n Ala Val1 Ile 55 Lys Ser Lys Thr Ala 135 Glu Giu Leu Leu Ile Lys 40 Thr Asp Ile Ser Arg 120 Pro Lys Lys Thr Ser 200 Giu 25 Val1 Ile GiU Val1 Asn 105 Asp Asp Glu Arg As n Glu 10 Ala Val1 Trp Thr Pro 90 Leu Pro Ala Lys 170 Aia Leu Vali Asn Thr Ile 75 Asn Met Gin Lys Lys G iu Met Ile Ala Lys Ser Ser Ser Phe C iu Giu 140 Giu Giu Ser Lys Leu Lys Leu Tyr Asn Giu Phe 125 Leu Gin Arg As n Gin 205 Asp Ile Asp Ile His Lys 110 Leu G lu Ala Ala Pro 190 Gin Ile Ala Asn Thr Ile Giu Lys Giu Gin Lys 175 Gin Arg Lys Tyr Val1 Thr Phe Ala Thr Gin Lys 160 As n As n Glu Asn Clii Leu Asp Gin Met Glu Arg Thr Arg Giy His Ala Arg Ala Gly 210 215 220 EA/US 18 DEC 1996 340 Ser Ser 225 INFORMATION FOR SEQ ID NO:407: SEQUENCE CHARACTERISTICS: LENGTH: 61 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...61 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:407 Leu Leu Leu Phe Phe Leu Leu Lys Gly Val Val Phe Ser Leu Gly Phe 1 5 10 Phe Ser Phe Phe Glu Glu Val Ser Gly Ser Phe Unk Ala Val Ser Leu 25 Unk Val Leu Ala Leu Val Met Gly Ser Ser Unk Gly Leu Glu Glu Phe 40 Cys Val Leu Glu Glu Leu Ile Asn Ser Gly Leu Ser Val 55 INFORMATION FOR SEQ ID NO:407: SEQUENCE CHARACTERISTICS: LENGTH: 61 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION 1...61 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:407 Leu Leu Leu Phe Phe Leu Leu Lys Gly Val Val Phe Ser Leu Gly Phe 1 5 10 Phe Ser Phe Phe Glu Glu Val Ser Gly Ser Phe Unk Ala Val Ser Leu 25 Unk Val Leu Ala Leu Val Met Gly Ser Ser Unk Gly Leu Glu Glu Phe 40 Cys Val Leu Glu Glu Leu Ile Asn Ser Gly Leu Ser Val 55 INFORMATION FOR SEQ ID NO:408: 341 SEQUENCE CHARACTERISTICS: LENGTH: 50 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...50 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:408 Met Asn Thr Glu Ile Leu Thr Ile Met Leu Val Val Ser Val Leu Met 1 5 10 Gly Leu Val Gly Leu Ile Ala Phe Leu Trp Gly Val Lys Ser Gly Gin 25 Phe Asp Asp Glu Lys Arg Met Leu Glu Ser Val Leu Tyr Asp Ala Arg 40 Ala Thr INFORMATION FOR SEQ ID NO:409: SEQUENCE CHARACTERISTICS: LENGTH: 122 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...122 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:409 Met Gly Phe Leu Lys Val Leu Lys His Asp Ala Leu Gly Gin Val Gly 1 5 10 Asn Ile Val Ile Gly Asn Phe Leu Ile Thr Leu Thr Val Leu Ala Val 25 Cys Phe Ser Ser Gin Ser Ala Glu Glu Thr Thr Met Leu Thr Leu Ser 40 Tyr Thr Leu Phe Phe Ile Leu Gly Ala Phe Leu Leu Val Ala Ile Ser 55 Val Gly Ala Ile Lys Asn Leu Asn Ala Leu Phe Ser Lys Arg Gly Val 70 75 Leu Ser Phe Ser Leu Pro Ile Ser Leu Glu Ser Leu Leu Leu Pro Lys 90 Ile Leu Leu Pro Unk Val Phe Phe Tyr Leu Gln Phe Val Leu Val Cys 100 105 110 G' Glu Arg Ala Phe Gly Leu Leu Pro Phe 115 120 342 INFORMATION FOR SEQ ID NO:409: SEQUENCE CHARACTERISTICS: LENGTH: 122 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...122 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:409 Met Gly Phe Leu Lys Val Leu Lys His Asp Ala Leu Gly Gin Val Gly 1 5 10 Asn Ile Val Ile Gly Asn Phe Leu Ile Thr Leu Thr Val Leu Ala Val 25 Cys Phe Ser Ser Gln Ser Ala Glu Glu Thr Thr Met Leu Thr Leu Ser 40 Tyr Thr Leu Phe Phe Ile Leu Gly Ala Phe Leu Leu Val Ala Ile Ser 55 Val Gly Ala Ile Lys Asn Leu Asn Ala Leu Phe Ser Lys Arg Gly Val 70 75 Leu Ser Phe Ser Leu Pro Ile Ser Leu Giu Ser Leu Leu Leu Pro Lys 90 Ile Leu Leu Pro Unk Val Phe Phe Tyr Leu Gin Phe Val Leu Val Cys 100 105 110 Gly Glu Arg Ala Phe Gly Leu Leu Pro Phe 115 120 INFORMATION FOR SEQ ID NO:410: SEQUENCE CHARACTERISTICS: LENGTH: 187 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...187 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:410 Met Leu Lys Thr His Leu Ser Ser Ala Arg Gly Val Val Val Leu Ser 1 5 10 Lys Ile Leu Pro Val Asn Val Val Leu Met Val Ser Val Arg Leu Phe 25 Ilu Lys Glu Leu Lys Arg Lys Pro Tyr Tyr Ile Ile Ala Ser Ala His PVA 9 912 18 DEC1996 Ser Unk Cys Asp Leu Ala Pro 145 Gly Gin Lys Gin Leu Val1 105 Ala Lys Ser Cys Ile 185 Lys Arg Giu Ile His Asp Giu Lys 170 Ser Unk Val1 Arg Val1 Phe Gly Ser Gin Leu Met Unk Lys Ser Ala Pro Met Ser 175 INFORMATION FOR SEQ ID NO:410: SEQUENCE CHARACTERISTICS: LENGTH: 187 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION .187 (xi) SEQUENCE DESCRIPTION: SEQ ID 1Met Leu Lys Thr His Leu Ser Ser Ala Arg Gly Val Val Val Leu Sen Lys Glu Ser Unk Cys Asp Leu Ala Pro 145 Gly Ile Lys Asp Unak Unk Thr Val1 Phe 130 Asp Thr Leu Glu Glu Pro Leu Leu Leu 115 Val1 Gly Ser Pro Leu Gly Thr Asp Leu 100 Arg Ile Glu Glu Val1 Lys Leu Lys Met Asp Lys Gly Thr Gly 165 Asn Ang G iu Leu 70 Glu Leu Leu Ile Ile 150 Va 1 Val Val Lys Pro 40 Lys Leu Met Ala Asn Ile Glu Glu Lys Giu 120 Thr Gin 135 Ile Ala Ala Thr Leu 25 Tyr Lys Gin Leu Val1 105 Ala Lys Ser Cys 10 Met Val Tyr Ile Lys Unk Ang Val 75 Glu Ang 90 Ile Val His Phe Asp Gly Glu Ser 155 Lys Gin 170 Ser I le Gly Sen Phe Pro Arg Lys 140 Lys Leu Val1 Ala Unk Ala Ile Lys Glu 125 Tyr Leu Ile Arg Sen Asp Asn Asn Thr 110 Ile Ile Leu Thr is Leu Ala Met Unk Lys Ser Ala Pro Met Se r 175 Phe His Val1 Tnp Lys Trp Lys Met Val1 160 His Gin Lys Pro Lys Glu Val Asp TyrleSrLu k18018 Ile Ser Leu 185 "PEA/US 6 nr 344 INFORMATION FOR SEQ ID NO:411: SEQUENCE CHARACTERISTICS: LENGTH: 130 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...130 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:411 Met Phe Val Ala Ala Gly Leu Gly Ala Tyr Ala Ile Ala Leu Phe His 1 5 10 Leu Phe Thr His Ala Phe Phe Lys Ser Leu Leu Phe Leu Gly Ser Gly 25 Asn Val Met His Ala Met Glu Asp Asn Leu Asp Ile Thr Lys Met Gly 40 Ala Leu Tyr Lys Pro Met Arg Ile Thr Ala Val Phe Met Ile Ile Gly 55 Ser Val Ala Leu Cys Gly Ile Tyr Pro Phe Ala Gly Tyr Phe Ser Lys 70 75 Asp Lys Ile Leu Glu Val Ala Phe Gly Met His His His Ile Leu Trp 90 Phe Val Leu Leu Ile Gly Ala Ile Phe Thr Ala Phe Tyr Ser Phe Arg 100 105 110 Leu Ile Met Leu Val Phe Phe Ala Pro Lys Gin His Glu Ile Asn His 115 120 125 Pro Pro 130 INFORMATION FOR SEQ ID NO:412: SEQUENCE CHARACTERISTICS: LENGTH: 183 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...183 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:412 Met Phe Ile Ser Ser Ser Tyr Thr Leu Ser Phe Val Trp Leu Phe Leu 71 5 10 Lle Phe Phe Phe Phe Lys Asn Lys Pro Leu Gly Leu Arg Phe Ser Leu POT/US 96/09122 Ser Ser Ser Lys Phe Ilie Ser 145 Ser Tyr Leu Leu so Cys Lys As n Tyr Ser 130 Leu Leu Leu Ile As n Leu Pro Leu His Leu Se r Leu Ala Ser Glu Leu Pro Leu 100 His Phe Ser Asp Lys 180 As n Phe Ala Gin Ile 105 Leu Leu Arg Leu Ile Thr Ser Ser Leu Ile Leu Ser Phe 170 Ala Ala Phe Tyr Gly Phe G ly Asn Val1 INFORMATION FOR SEQ ID NO:4i3: SEQUENCE CHARACTERISTICS: LENGTH: 193 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .193 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:413 Val Gly Ser Phe Leu Phe Val Gly Pro Ser Gly Val Gly Lys Thr Giu 1 Leu Asp Ser Ala Lys Ala Ile Gly Leu 145 Ala Met Pro Ile Ala Thr Leu Phe 130 Leu Lys Ser Ser Lys His Leu Ilie Phe Thr GiU GlU Gly Lys Pro Ser 100 Met Se r Pro Leu Tyr Tyr His Asn Asp Thr Thr Giu Ala Lys Val Pro 70 Val1 Asn Unk Lys Leu I50 Leu Giu Gly 55 His Tyr Leu Unk As n 135 Arg Asn Ala 40 Phe Cys Asp Gly Val1 120 Ala Ser Leu 25 His Glu Leu Leu Asn 105 Gly Lys Arg Unk Ser Gin Leu Leu Lys Ser Tyr Ile Leu Val1 Gly Leu 75 Leu Ala Lys Asp Asp 155 His Ala Gly Leu Gin Ser Asp Arg 140 Ala Phe Lys Leu Asp Val1 Phe Lys 125 Ala Ile Glu Leu Leu Glu Met Lys 110 Asp Val1 Val1 Arg Ile Val Ile Unk His Thr Lys Pro Phe Gly Asn GlU Asri Val1 Leu Glu Ph.
160 Asn Ala Leu Ser Leu Giu Asp Phe Glu Thr His Cys Ph. Cys Gly Ile k16S 170 175 ?CTiJUS 96/09122 346 Gly Arg Val Lys Ser Pro Ser Thr Arg Ala Arg Arg Asp Leu Lys Ile 180 185 190 Pro INFORMATION FOR SEQ ID NO:413: SEQUENCE CHARACTERISTICS: LENGTH: 193 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...193 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:413 Val Gly Ser Phe Leu Phe Val Gly Pro Ser Gly Val Gly Lys Thr Glu 1 5 10 Leu Ala Lys Glu Leu Ala Leu Asn Leu Unk Leu His Phe Glu Arg Phe 25 Asp Met Ser Glu Tyr Lys Glu Ala His Ser Val Ala Lys Leu Ile Gly 40 Ser Pro Ser Gly Tyr Val Gly Phe Glu Gln Gly Gly Leu Leu Val Asn 55 Ala Ile Lys Lys His Pro His Cys Leu Leu Leu Leu Asp Glu Ile Glu 70 75 Lys Ala His Pro Asn Val Tyr Asp Leu Leu Leu Gln Val Met Unk Asn 90 Ala Thr Leu Ser Asp Asn Leu Gly Asn Lys Ala Ser Phe Lys His Val 100 105 110 Ile Leu Ile Met Thr Unk Unk Val Gly Ser Lys Asp Lys Asp Thr Leu 115 120 125 Gly Phe Phe Ser Thr Lys Asn Ala Lys Tyr Asp Arg Ala Val Lys Glu 130 135 140 Leu Leu Thr Pro Glu Leu Arg Ser Arg Ile Asp Ala Ile Val Pro Phe 145 150 155 160 Asn Ala Leu Ser Leu Glu Asp Phe Glu Thr His Cys Phe Cys Gly Ile 165 170 175 Gly Arg Val Lys Ser Pro Ser Thr Arg Ala Arg Arg Asp Leu Lys Ile 180 185 190 Pro INFORMATION FOR SEQ ID NO:414: SEQUENCE CHARACTERISTICS: LENGTH: 235 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein \(iii) HYPOTHETICAL: YES 9 G/zg In PFPWUS 18 DEC 1996 347 (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...235 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:414 Met Arg Leu Asp Tyr Ala Leu Phe Asn Gln His Leu Ala Asn Ser 1 Glu Met Glu Gly Leu Lys Asp Asp Asp 145 Leu Arg Ile Phe Asn 225 Lys Val Leu Ala Asp Gly Glu Ile 130 Val Ser Thr Leu Gin 210 Val Ala Val Ile Phe Val Ala Ser 115 Arg Ser Gly Ile Asn 195 Ile Glu 5 Ala Lys Pro Glu Ala Lys Lys Phe Ile Phe 165 Arg Leu Thr Phe Leu Pro Asn Asp 70 Ser Val Asn Lys Ser 150 Leu Asn Glu Ile Ile 230 Val Ser Leu His Lys Leu Asp Thr 135 Leu Thr Lys Asn Gin 215 His Leu Phe 40 Phe Phe Gly Cys Gin 120 Pro Tyr Leu Lys Phe 200 Glu Phe 10 Lys Val Ser Asp Phe 90 Asp Ile Lys Ile Lys 170 Val Asn Leu Arg Leu Gly Gly Glu Val Lys Tyr 125 Leu Ala Phe Asp Lys 205 Gly Val Asp Glu Lys Ala Met 110 Glu Ala Ile Glu Lys 190 Thr Lys Asn Gin Lys Val Leu Gin Glu Leu Leu Val 175 Glu Lys Asn Arg Lys Ile Leu Val Leu Leu Cys Cys Pro 160 Gly Ala Asp Gly INFORMATION FOR SEQ ID NO:415: SEQUENCE CHARACTERISTICS: LENGTH: 88 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc.feature LOCATION 1...88 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:415 Met Ser Leu Pro Pro Val Cys Ile Leu Lys Asp Val Asn His Leu Leu 1 5 10 ,Gin Val Leu His Ser Leu Val Ala Leu Gly Asn Ser Met Leu Val Ile 25 8DEC 1996 348 Glu His Asn Leu Asp Ile Ile Lys Asn Ala Asp Tyr Ile Ile Asp Met 40 Gly Pro Asp Gly Gly Asp Lys Gly Gly Lys Val Ile Ala Ser Gly Thr 55 Pro Leu Glu Val Ala Gln Asn Cys Glu Lys Thr Gln Ser Tyr Thr Gly 70 75 Lys Phe -Leu Ala Leu Glu Leu Lys INFORMATION FOR SEQ ID NO:416: SEQUENCE CHARACTERISTICS: LENGTH: 109 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...109 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:416 Met Gln Asn Arg Ser His Glu Ile Gln Gly Val Ser His Ile Lys Asn 1 5 10 Asn Tyr Lys Phe Phe Thr Lys Glu Leu Asp Asn Tyr Ile Ser Lys Gly 25 Tyr Arg Ile Giu Glu Ile Tyr Gly Ala Phe Leu Trp Leu Lys Ile Val 40 Ala Ile Gly Leu Glu Leu Gly Glu Asp Asp Pro Gln Val Val Phe Glu 55 Ser Ile Asn Ala Thr Gly Val Gln Leu Lys Gly Leu Asp Leu Ile Arg 70 75 Asn Tyr Leu Met Met Gly Glu Asn Unk Asp Asn Gln Asn Arg Leu Tyr 90 Asn Thr Tyr Trp Val Pro Leu Glu Asn Trp Leu Gly Glu 100 105 INFORMATION FOR SEQ ID NO:417: SEQUENCE CHARACTERISTICS: LENGTH: 107 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature B) LOCATION .107 4/ (xi) SEQUENCE DESCRIPTION: SEQ ID NO:417 Met Lys Val1 Asp Leu His Thr Asp Ser Gly Ile Leu Val1 Ile Thr Ser Ile Val1 Leu Phe Phe Ile Pro Leu Val1 Pro Ser Tyr 100 Lys Lys Link As n Thr C ly Lys Ile Leu Ile Lys Trp Lys Ser 105 Arg Ala Leu His Gly Leu Ala INFORMATION FOR SEQ ID NO:418: SEQUJENCE CHARACTERISTICS: LENGTH: 136 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .136 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:4i8 Met Ile Phe Tyr Thr Thr Ile Lys Glu Pro Leu Lys Asn Leu Gin Tyr 1 Arg Ser Lys Ser Ser His Val1 Phe Tyr Leu Gin As n Leu Leu Tyr Pro 130 Ala Lys Asp Ala Asn Leu Phe 115 Tyr Phe Phe Ser Gly 70 Leu Ser Ser Ala Gly Phe His 55 Asn Arg Gly Leu Phe 135 Lys Gin 40 Leu Leu Asp Phe Phe 120 Link Ile Thr Arg Tyr Arg His 105 Tyr 10 Lys Tyr His Ala Leu Thr Pro Ser Phe Ala Asn Gly Pro Cys Phe Ile Leu Ala Ile Leu Ser Ser Asp Phe Leu Leu Gin 125 is Phe Leu Leu Thr Ser Ala le-Giy Gly Ile Ser Ala 110 Lys Arg INFORMATION FOR SEQ ID NO:4i9: SEQUENCE CHARACTERISTICS: LENGTH: 54 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein S 9I6/0 1 2 2 350 (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...54 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:419 Met Asn Lys Pro Phe Leu Ile Leu Leu Ile Ala Leu Ile Ala Phe Ser 1 5 10 Gly Cys Asn Met Arg Lys Tyr Phe Lys Pro Ala Lys His Gin Ile Lys 25 Ala Lys Arg Ile Ser Leu Thr Ile Cys Lys Lys Ala Ser Phe Arg Leu 40 Ile Val Met Glu Pro Phe INFORMATION FOR SEQ ID NO:420: SEQUENCE CHARACTERISTICS: LENGTH: 125 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...125 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:420 Met Ala Ala Trp Asn Thr Leu Val Glu Lys Ile Ile Ala Pro Lys His 1 5 10 Lys Val Lys Ile Gly Phe Val Gly Lys Tyr Leu Ser Leu Lys Glu Ser 25 Tyr Lys Ser Leu Ile Glu Ala Leu Ile His Ala Gly Ala His Leu Asp 40 Thr Gin Val Asn lile Giu Trp Leu Asp Ser Glu Asn Phe Asn Glu Lys 55 Thr Asp Leu Glu Gly Val Asp Ala Ile Leu Val Pro Gly Gly Phe Gly 70 75 Glu Arg Gly Ile Glu Gly Lys Ile Cys Ala Ile Gin Arg Ala Arg Leu 90 Glu Lys Leu Pro Phe Leu Gly Ile Cys Leu Gly Met Gin Leu Ala Ile 100 105 110 Val Glu Phe Cys Arg Lys Cys Phe Arg Leu Glu Arg Gly 115 120 125 INFORMATION FOR SEQ ID NO:421: SEQUENCE CHARACTERISTICS: LENGTH: 249 amino acids TYPE: amino acid EkMlS~%~99 351 TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .249 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:421 Met Leu Gly Gly Thr Leu Gin Thr Arg Gly 145 As n Phe Pro Gly Met 225 Phe Thr Ala Phe Glu s0 Glu Ser As n Gin As n 130 Thr Lys Pro Arg Val1 210 Thr Arg Lys Phe Leu Phe Asn Gin G ly Gly 115 Lys Asp As n Leu Phe 195 Tyr Phe Lys Ala Phe Val Pro Leu Sen Leu Leu Val Ser Ang Giy As n Glu Val1 100 Asp Leu Tyr Gin Ala 180 Lys Phe Phe Phe Leu Gin Gin Ser Sen Phe Lys Lys Leu Lys 165 Ser Thr Leu Phe Ile 245 Ile Lys Lys Tyr 70 Phe Giu Met Se r Gly 150 Arg Val1 As n Met Pro 230 Leu Leu Lys Leu 55 Asp Ile Leu Ang Phe 135 Tyr Arg Phe Trp Val1 215 Phe Lys Ile Asp 40 G ly As n Leu As n Lys 120 As n Tnp Phe Leu Ser 200 His Ile Arg Pro 25 Lys Asp Leu Ala Leu 105 Val1 Sen Lys Se r Ile 185 Tyr Val1 Trp Tyr Thr Ile Trp Val1 Gin 90 Tyr Asp As n Lys Gin 170 Pro Phe Ile Ala Sen Asp Leu Leu 75 Lys As n Phe Asp Aia 155 Ala Leu Unk Ser Phe 235 Lys Ile Val1 Phe Gly Gly Giu Ala 140 Phe Ile Phe Val1 Thr 220 Ile Ser Ser As n Tyr Ser As n His Giu 125 Ala Gly Leu Gly Leu 205 Asp Ser Ala Aia Ile Val1 Asn Ile Ala 110 Leu Tyr Lys Val1 Ile 190 G ly Leu Tyr Ile Tyr Arg Asp Lys As n Tyr His Leu As n Ser 175 Ala Ala Phe Leu Leu Tyr Ala Lys Ser Asn Phe Leu Gin Ala 160 Leu Asn Val1 Leu Leu 240 INFORMATION FOR SEQ ID NO:422: SEQUENCE CHARACTERISTICS: LENGTH: 86 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature PT 96/09122 S 1 8 EC 96 352 LOCATION 1...86 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:422 Met Ser Lys Ser Ala Ile Phe Val Leu Ser Gly Phe Leu Ala Phe Leu 1 5 10 Leu Tyr Ala Leu Leu Leu Tyr Gly Leu Leu Leu Glu Arg His Asn Lys 25 Glu Ala Glu Lys Ile Leu Leu Asp Leu Asn Lys Lys Asp Glu Gln Ala 40 Ile Asp Leu Asn Leu Glu Asp Leu Pro Ser Glu Lys Lys Asn Glu Lys 55 Ile Lys Lys Val Thr Glu Lys Gin Asp Asp Phe Leu Glu Pro Lys Arg 70 75 Arg Thr Gin Arg Gly Ala INFORMATION FOR SEQ ID NO:423: SEQUENCE CHARACTERISTICS: LENGTH: 128 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...128 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:423 Val Met Ala Gin Ser Leu Leu Val His Ala Phe Phe Ala Ala Leu Leu 1 5 10 Ala Leu Ala Phe Met Ile Asn Leu Tyr Thr Leu Phe Lys Glu Lys Asn 25 Phe Ile Gin Leu Asn Arg Lys Ile Tyr Leu Val Met Pro Ala Ile Tyr 40 Ile Leu Leu Ser Ile Ala Leu Leu Ser Gly Val Phe Ile Trp Ala Met 55 Gin Gin Phe Glu Phe Ser Phe Ser Ala Val Val Met Leu Leu Gly Leu 70 75 Leu Leu Met Leu Ile Ala Glu Ile Lys Arg His Lys Ser Val Lys Phe 90 Ala Ile Thr Lys Lys Glu Arg Met Lys Ala Tyr Ile Lys Lys Ala Lys 100 105 110 Ile Leu Tyr Phe Leu Glu Thr Ile Leu Ile Ile Val Leu Met Gly Ile 115 120 125 INFORMATION FOR SEQ ID NO:424: SEQUENCE CHARACTERISTICS: LENGTH: 93 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein PCT/U& 96/09122 (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc feature LOCATION 1...93 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:424 Arg Asn Val Val Leu Phe Ile Leu Thr Ala Ile 10 Leu Leu Val Ser Tyr Cys Met Pro His Tyr Ser 25 Gly Val Glu Val Lys Arg Met Asn Glu Asn Glu 40 Lys Glu Val Lys Thr Leu Ala Arg Asp Val Tyr 55 Asp Pro Lys Asp Gln Lys Ser Val Thr Val Tyr 75 Arg Phe Gly Phe Pro Phe Tyr Phe Lys Phe Asn Phe Leu Ala Phe Val Ala Val Ile Asn Thr Pro Asn Phe Val Gin Thr Arg Asn GIu Asp Ser INFORMATION FOR SEQ ID NO:425: SEQUENCE CHARACTERISTICS: LENGTH: 88 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter.pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...88 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:425 Met Phe Lys Lys Ile Ile Phe Leu Cys Val Phe Leu Ile Gly Gly Phe 1 5 10 Val Ile Pro Pro Leu Glu Ala Met Pro Ile Leu Arg Asn Lys Thr Pro 25 Lys Lys Asn Tyr Gin Glu Ala His Glu Lys Leu Tyr Arg Ser Ile Ile 40 Asn Arg Gln Unk Unk Thr Arg Lys Lys Ser Gly Trp Tyr Phe Leu Gly 55 Gly Val Gly Ala Val Glu Ala Ile Lys Asp Tyr Gin Gly Lys Glu Met 70 75 Lys Asp Trp Met Pro Arg Ser Ile INFORMATION FOR SEQ ID NO:426: SEQUENCE CHARACTERISTICS: LENGTH: 128 amino acids TYPE: amino acid TOPOLOGY: linear Po S 96/091 2 2 i 8 DEC 1996 354 (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...128 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:426 Val His Phe Thr Cys Ile Phe Leu Thr Leu Leu Lys Trp Ile Leu Pro 1 5 10 Ala Lys Asn Lys Gin Ala Cys Lys Lys Ala Thr Asn Gin Ile His Ser 25 Arg Unk Ala Lys His Pro Ala Lys Tyr Pro Pro Ser Ser Ile Asn Pro 40 Ser Ile Gln Ala Gly Ile Gin Gly Val Met Gln Gly Phe Gly Ala Leu 55 Ser Ser Unk Leu Glu Unk Pro Unk Phe Val Unk Unk Ala Lys Cys Gly 70 75 Trp Ile Gly Gly Phe Glu His Tyr Leu Ser Pro Leu Tyr Gly Trp Gly 90 Lys Ile His Asp Gly Ala His Cys Asp Leu Met Gin Lys Asp Ala Asn 100 105 110 Gly Arg Gly Ile Gly Leu Glu Lys Gly Leu Pro Pro Phe Lys Gly Leu 115 120 125 INFORMATION FOR SEQ ID NO:427: SEQUENCE CHARACTERISTICS: LENGTH: 108 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...108 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:427 Met Gin Lys Phe Phe Ser Arg Phe Arg Arg Trp Ala Leu Pro Phe Tyr 1 5 10 Phe Val Ser Ala Leu Ala Ala Ile Asp Ile Asp Glu Val Thr Glu Ala 25 Gin Ala Asn Ser Ile Lys Leu Ser Asp Gin Leu Val Ser Leu Ser Asp 40 Lys Leu Leu Glu Lys Ala Val Asp Arg Gly Arg Asn Thr Asp His Leu 55 Lys Asp Leu Asn Asp Leu His Glu Lys Ile Lys His Leu Arg Leu Ile 70 75 Leu Glu Pro Lys Pro Lys Gly Lys Glu Asp Ser Pro Asn Leu Gly Gly 90 fsn Lys Asp Met Lys Thr Val Glu Ile Gly Ser Gly poT I C a 1 22 PEA/US 18 DEC 1996 355 100 105 INFORMATION FOR SEQ ID NO:428: SEQUENCE CHARACTERISTICS: LENGTH: 118 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...118 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:428 Val Ile Leu Ala Phe Ala Phe Gly Met Ser Leu Leu Gly Leu Ala Gly 1 5 10 Met Phe Ile Asp Ile Pro Phe Leu Ser Thr Gly Val His Ile Pro Arg 25 Lys Glu Asp Ile Leu Trp Ile Ser Leu Ile Gly Ile Ser Gly Thr Leu 40 Gly Gln Tyr Phe Leu Thr Tyr Ala Tyr Met Asn Ala Pro Ala Gly Ile 55 Ile Ala Pro Ile Glu Tyr Thr Arg Ile Val Trp Gly Leu Leu Phe Gly 70 75 Leu Tyr Leu Gly Asp Thr Phe Leu Asp Leu Lys Ser Ser Leu Gly Val 90 Ala Leu Ile Leu Cys Ser Gly Leu Leu Ile Ala Leu Pro Ala Leu Leu 100 105 110 Lys Glu Leu Lys Lys Ile 115 INFORMATION FOR SEQ ID NO:429: SEQUENCE CHARACTERISTICS: LENGTH: 54 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...54 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:429 Met Ile Tyr Leu Gly Lys Lys Asn Phe Asn Ala Leu Leu Lys Gly Ala 1 5 10 Tyr Leu Met Asp Glu His Phe Arg Asn Ala Pro Phe Glu Ser Asn Leu 25 R S 96/09122 S18 DEC 1996 356 Pro Val Leu Met Gly Leu Ile Trp Arg Val Val Tyr Leu Thr Phe Phe 40 Pro Ile Gln Lys Ala Thr INFORMATION FOR SEQ ID NO:430: SEQUENCE CHARACTERISTICS: LENGTH: 288 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...288 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:430 Met Ala Ala Lys Ser Lys Ala Unk Thr Leu Lys Val Phe Ser Lys Phe 1 5 10 Phe Ser Asn Phe Lys Ile Thr Lys Leu Lys Asp Asn His Glu Glu Ala 25 His Lys Leu Phe Gly Glu Asn Ser Arg Lys Ala His Asp Thr Glu Ile 40 Ile Tyr Ser Thr Leu Gln Val Val Pro Arg Tyr Ser Ile Glu Thr Val 55 Gly Phe Ser Leu Leu Ile Leu Ala Val Ala Tyr Ile Leu Phe Lys Tyr 70 75 Gly Glu Ala Arg Met Val Leu Pro Thr Ile Ser Met Tyr Ala Leu Ala 90 Leu Tyr Arg Ile Leu Pro Ser Val Thr Gly Val Ile Ser Tyr Tyr Asn 100 105 110 Glu Ile Ala Tyr Asn Gln Leu Ala Thr Asn Val Val Phe Lys Ser Leu 115 120 125 Ser Lys Thr Ile Val Glu Glu Asp Leu Val Pro Leu Asp Phe Asn Glu 130 135 140 Lys Ile Thr Leu Gln Asn Ile Ser Phe Ala Tyr Lys Ser Lys His Pro 145 150 155 160 Val Leu Lys Asn Phe Asn Leu Thr Ile Gln Lys Gly Gln Lys Ile Ala 165 170 175 Leu Ile Gly His Ser Gly Cys Gly Lys Ser Thr Leu Ala Asp Ile Ile 180 185 190 Met Gly Leu Thr Tyr Pro Lys Ser Gly Giu Ile Phe Ile Asp Asn Thr 195 200 205 Leu Leu Thr Ser Glu Asn Arg Arg Ser Trp Arg Lys Lys Ile Gly Tyr 210 215 220 Ile Pro Gln Asn Ile Tyr Leu Phe Asp Gly Thr Val Gly Asp Asn Ile 225 230 235 240 Ala Phe Gly Ser Ala Ile Asp Glu Lys Arg Leu Ile Lys Val Cys Lys 245 250 255 Met Ala His Ile Tyr Asp Phe Leu Cys Glu His Glu Gly Leu Lys Thr 260 265 270 Gin Val Gly Glu Gly Ala Leu Ser Leu Ala Ala Val Lys Asn Ser Ala 275 280 285 INFORMATION FOR SEQ ID NO:431: K IUS JEC 1i99 SEQUENCE CHARACTERISTICS: LENGTH: 303 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .303 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:431 1Met Ala Phe Gin Val Asn Thr Asn Ile Asn Ala Gin Ser Thr Ile Ala Thr Gin Thr Lys 145 Ile Gly Val1 Sen Ser 225 Asp Ile Arg Ala Ser Ser Val1 Ala Met Gin Sdr Thr 130 Glu G ly Ala Asp Ala 210 Asn Val1 His Leu Tyr 290 Ala Gly Ala Asn Asp Ala Asp 115 Thr Phe Sen Leu Gly .195 Gly Arg Ala Leu Val1 275 Thr Leu Leu Asp Thr Glu Ala 100 Ile Tyr Gin Thr Ile 180 Val1 Thr Thr Val1 Gly 260 Thr Asp Thr Arg Se r As n Gin Gin Val1 As n Val1 Thr 165 Thr Asn Gly Gly Gin 245 Asn Ala Gin Gin Ile Leu Asp 70 Leu Asp Arg Gly Gly 150 Se r Ala Asp Ile Val 230 Ser Ile Ile Lys Asn As n Arg 55 Gly Lys Gly Leu Gin 135 Ala Asp Ser Val1 Gly 215 Lys Gly Ala Asn Gly 295 Ala Lys 40 Ser Met Ile Gln Ile 120 Ala Tyr Lys Giy Thr 200 Val1 Ala Ser Asp Ala 280 Arg Leu 25 Ala Gin Gly Leu Thr 105 Gin Leu Ser Ile Asp 185 Leu Leu Leu Ile 265 Val1 Leu Lys Ala Ala Ile Asp 90 Thr Gly Leu As n Gly 170 Ile Giu Ala Ala Ser 250 Lys Thr Asn Thr Asp Ser Ile 75 Thr Glu Leu Ser Gin Gin Sen Ser Giu Ser 235 Asn Unk Sen Leu Met Ser Asp Ser Gin Val1 Sen Asp Gly 140 Ser Val1 Leu Val1 Val1 220 Val1 Leu Asn Giu Arg 300 Asn Ala Leu Giu Ala Ser Leu Gly Val Ala Lys Val Arg Lys 110 Asn Ile 125 Gin Phe Ile Lys Arg Ile Thr Phe 190 Lys Val 205 Ile Asn Ile Thr Thr Leu Asp Ser 270 Thr Gly 285 Ser Ile His Arg Giy Gin Asp Lys Ala Gly Thr Ala Ala 175 Lys Sen Lys Thr Asn 255 Asp Val1 Gly Val1 Leu Met Ala Lys Ala Ile Asn Asn Ser 160 Thr Gin Sen Asn Ser 240 Gly Gly Unk INFORMATION FOR SEQ ID NO:431: SEQUENCE CHARACTERISTICS: LENGTH: 303 amino acids TYPE: amino acid TOPOLOGY: linear PCT/U~ 9 (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .303 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:431 Met Ala Phe Gin Val Asn Thr Asn Ile Asn Ala Met 1 Gin Ser Thr Ilie Ala Thr Gin Thr Lys 145 Ile Gly Val1 Ser Sen 225 Asp Ile Arg Ala Ser Sen Val1 so Ala Met Gin Ser Thr 130 Glu Gly Ala Asp Ala 210 As n Val1 His Leu Tyr 290 Ala Gly Ala As n Asp Ala Asp 115 Thr Phe Ser Leu Gly 195 Gly Arg Ala Leu Val1 275 Thr Leu Leu Asp Thr Glu Ala 100 Ile Tyr Gin Thr Ile 180 Val1 Thr Thr Val1 Gly 260 Thr Asp 5 Thr Arg Ser As n Gin Gin Val1 As n Val1 Thr 165 Thr Asn Giy Gly Gin 245 Asn Ala Gin Gln Ile Leu Asp 70 Leu Asp Arg Giy G ly 150 Se r Ala Asp Ile Val1 230 Ser Ile Ile Lys Asn As n Arg 55 Gly Lys Gly Lou Gin 135 Ala Asp Sen Val1 Gly 215 Lys Gly Ala Asn Gly 295 Leu 25 Ala Gin 0 iy Lou Thr 105 Gin Leu Ser Ile Asp 185 Leu Leu Tyr Leu Ile 265 Val Leu Lys Ala Ala Ile Asp 90 Thr Gly Lou Asn Gly 170 Ile Giu Ala Ala Ser 250 Lys Thr Asn Thr Asp Ser Ile 75 Thr G lu Lou Ser Gin 155 Gin Ser Ser Giu Ser 235 As n Unk Ser Leu Ser Asp Sen Gin Val1 Ser Asp Gly 140 Ser Val1 Leu Val Val 220 Val1 Leu Asn Glu Arg 300 Asn Leu Ala Lou Val Lys Arg As n 125 Gin Ile Arg Thr Lys 205 Ile Ile Thr Asp Thr 285 Sen Ala Glu Ser Gly Ala Val1 Lys 110 Ile Phe Lys Ile Phe 190 Val1 Asn Thr Leu Ser 270 Gly Ile His Arg Gly Gin Asp Lys Ala Gly Thr Ala Ala 175 Lys Sen Lys Thr As n 255 Asp Val1 Gly Val Leu Met Ala Lys Ala Ile Asn Asn Sen 160 Thr Gin Ser Asn Ser 240 Gly Gly Unk INFORMATION FOR SEQ ID NO:432: SEQUENCE CHARACTERISTICS: LENGTH: 192 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES 18 DEC 1996 359 (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...192 (xij SEQUENCE DESCRIPTION: SEQ ID NO:432 Met Leu Asp Ile Trp Ile Asp Met Ile Ile Cys Ile Phe Tyr Leu Leu 1 5 10 Phe Phe Thr Thr Pro Tyr Ile Val Gly Asp Ile Leu Gln Leu Lys Phe 25 Ile Arg Gin Lys Leu Cys Glu Lys Pro Val Leu Leu Pro Gin Lys Asp 40 Tyr Glu Glu Ala Gly Asn Tyr Ala Ile Arg Lys Met Gin Leu Ser Ile 55 Ile Ser Gin Ile Leu Asp Gly Val Ile Phe Ala Gly Trp Val Phe Phe 70 75 Gly Leu Thr His Leu Glu Asp Leu Thr His Tyr Leu Asn Leu Pro Glu 90 Thr Leu Gly Tyr Leu Val Phe Ala Leu Leu Phe Leu Ala Ile Gin Ser 100 105 110 Val Leu Ala Leu Pro Ile Ser Tyr Tyr Thr Thr Met His Leu Asp ys 115 120 125 Glu Phe Gly Phe Ser Lys Val Ser Leu Ser Leu Phe Phe Lys Asp Phe 130 135 140 Phe Lys Gly Leu Leu Leu Thr Leu Gly Val Gly Leu Leu Leu Ile Tyr 145 150 155 160 Thr Leu Ile Met Ile Ile GIu His Val Glu His Trp Glu Ile Ser Ser 165 170 175 Phe Phe Val Val Phe Val Phe Met Ile Leu Ala Asn Leu Phe Leu Pro 180 185 190 INFORMATION FOR SEQ ID NO:433: SEQUENCE CHARACTERISTICS: LENGTH: 168 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii).HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...168 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:433 Met Leu Lys Lys Ile Phe Leu Thr Asn Ser Leu Gly Ile Leu Cys Ser 1 5 10 Arg Ile Phe Gly Phe Leu Arg Asp Leu Met Met Ala Asn Ile Leu Gly 25 Ala Gly Val Tyr Ser Asp Ile Phe Phe Val Ala Phe Lys Leu Pro Asn 40 Leu Phe Arg Arg Ile Phe Ala Glu Gly Ser Phe Ser Gin Ser Phe Leu 55 Pro Ser Phe Ile Arg Ser Ser Ile Lys Gly Gly Phe Ala Ser Leu Val 70 75 360 Gly Leu Ile Phe Cys Gly Val Leu Phe Met Trp Cys Leu Leu Val Ala 90 Leu Asn Pro Leu Trp Leu Thr Lys Leu Leu Ala Tyr Gly Phe Asp Glu 100 105 110 Glu Thr Leu Lys Leu Cys Thr Pro Ile Val Ala Ile Asn Phe Trp Tyr 115 120 125 Leu Leu Leu Val Phe Ile Thr Thr Phe Leu Gly Ala Leu Leu Gin Tyr 130 135 140 Lys His Ser Phe Phe Ala Ala Leu Met Arg Lys Leu Thr Gin Phe Met 145 150 155 160 His Asp Phe Ser Pro Phe Asp Phe 165 INFORMATION FOR SEQ ID NO:434: SEQUENCE CHARACTERISTICS: LENGTH: 153 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...153 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:434 Met Asn Leu Glu Val Ala Leu Lys Ala Phe Glu Thr Leu Leu Pro Cys 1 5 10 Asn Lys Gln Glu Val Leu Lys Asn Leu Lys Pro Leu Asp Leu Ile Gly 25 Arg Cys Glu Leu Leu Ser Pro Asn Ile Leu Ile Asp Val Gly His Asn 40 Pro His Ser Ala Lys Ala Leu Lys Glu Glu Ile Lys Arg Ile Phe Asn 55 Ala Pro Ile Val Leu Ile Tyr Asn Cys Tyr Gln Asp Lys Asp Ala Phe 70 75 Leu Val Leu Glu Ile Leu Lys Ser Val Val Lys Lys Val Leu Ile Leu 90 Glu Leu His Asn Glu Arg Ile Ile Gln Leu Glu Lys Leu Lys Gly Ile 100 105 110 Leu Glu Thr Leu Gly Leu Glu His Ala Leu Phe Glu Glu Leu Lys Glu .115 120 125 Asn Glu Asn Tyr Leu Val Tyr Gly Ser Phe Leu Val Ala Asn Ala Phe 130 135 140 Tyr Glu Arg Tyr Pro Lys Lys Arg Asp 145 150 INFORMATION FOR SEQ ID NO:435: SEQUENCE CHARACTERISTICS: LENGTH: 161 amino acids TYPE: amino acid TOPOLOGY: linear S(ii) MOLECULE TYPE: protein PCT/US 9 6 0 12 IPENUS 18 DEC 1996 361 (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...161 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:435 Met Phe Phe Lys Thr Tyr Gin Lys Leu Leu Gly Ala Ser Cys Leu Ala 1 5 10 Leu Tyr Leu Val Gly Cys Gly Asn Gly Gly Gly Gly Glu Ser Pro Val 25 Glu Met Ile Unk Asn Ser Glu Gly Thr Phe Gin Ile Asp Ser Lys Ala 40 Asp Ser Ile Thr Ile Gin Gly Val Lys Leu Asn Arg Gly Asn Cys Ala 55 Val Asn Phe Val Pro Val Ser Glu Thr Phe Gln Met Gly Val Leu Ser 70 75 Gin Val Thr Pro Ile Ser Ile Gin Asp Phe Lys Asp Met Ala Ser Thr 90 Tyr Lys Ile Phe Asp Gln Lys Lys Gly Leu Ala Asn Ile Ala Asn Lys 100 105 110 Ile Ser Gln Leu Glu Gln Lys Gly Val Met Met Lys Pro Unk Thr Leu 115 120 125 Asn Phe Gly Glu Ser Leu Lys Gly Ile Ser Gln Gly Cys Asn Ile Ile 130 135 140 Glu Ala Glu Ile Gln Thr Asp Lys Gly Ala Trp Thr Phe Asn Phe Asp 145 150 155 160 Lys INFORMATION FOR SEQ ID NO:435: SEQUENCE CHARACTERISTICS: LENGTH: 161 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...161 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:435 Met Phe Phe Lys Thr Tyr Gin Lys Leu Leu Gly Ala Ser Cys Leu Ala 1 5 10 Leu Tyr Leu Val Gly Cys Gly Asn Gly Gly Gly Gly Glu Ser Pro Val 25 Glu Met Ile Unk Asn Ser Glu Gly Thr Phe Gin Ile Asp Ser Lys Ala 40 Asp Ser Ile Thr Ile Gin Gly Val Lys Leu Asn Arg Gly Asn Cys Ala 55 Val Asn Phe Val Pro Val Ser Glu Thr Phe Gin Met Gly Val Leu Ser 70 75 ~P~S9 6 /0 9 1 Z 2 PT~ r.
Gin Tyr Ilie As n Giu 145 Lys 362 Vai Thr Pro Ile Ser Ile Gin Asp Phe Lys Asp met Aia Lys Ilie Phe Asp Gin Lys Lys Giy Leu Aia Asn Ilie Ala 100 10S 110 Ser Gin Leu Giu Gin Lys Giy Val Met Met Lys Pro Unk 115 120 125 Phe Gly Giu Ser Leu Lys Gly Ile Ser Gin Gly Cys Asn 130 135 140 Ala Giu Ile Gin Thr Asp Lys Giy Aia Trp Thr Phe Asn iso iss INFORMATION FOR SEQ ID NO:436: SEQUENCE CHARACTERISTICS: LENGTH: 59 amino acids TYPE: amino acid TOPOLOGY: iinear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL
SOURCE:
ORGANISM: Heiicobacter pyiori (ix) FEATURE: NAME/KEY: miscfeature LOCATION i 59 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:436 Met *Aia Ile Giy Ph. Pro Leu Vai Phe Giy Ile Leu Leu Thr Leu Phe 10 is Ser Arg Ser Tyr Trp Arg Giu Phe Giy Giy Vai Ser Giy Vai Leu Trp 25 Arg Aia Ser Giy Phe Ser Giy Aia Lys Val Giu Arg Asn Leu Giu Arg 40 Asp Pro His Aia Phe Ph. Thr His Cys Asp Phe INFORMATION FOR SEQ ID NO:437: SEQUENCE CHARACTERISTICS: LENGTH: 222 amino acids TYPE: amino acid TOPOLOGY: iinear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Heiicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION i1 .222 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:437 \Met Lys Lys Lys Aia Lys Vai Ph. Trp Cys Cys Ph. Lys Met Ile Arg \\42aO Z/t -JflO SHEET PCILUS 96 0 9 12 363 1 5 10 Trp Leu Tyr Leu Ala Val Phe Phe Leu Leu Ser Val Ser Asp Ala Lys 25 Glu Ile Ala Met Gin Arg Phe Asp Lys Gin Asn His Lys Ile Phe Glu 40 Ile Leu Ala Asp Lys Val Ser Ala Lys Asp Asn Val Ile Thr Ala Ser 55 Gly Asn Ala Ile Leu Leu Asn Tyr Asp Val Tyr Ile Leu Ala Asp Lys 70 75 Val Arg Tyr Asp Thr Lys Thr Lys Glu Ala Leu Leu Glu Gly Asn Ile 90 Lys Val Tyr Arg Gly Glu Gly Leu Leu Val Lys Thr Asp Tyr Val Lys 100 105 110 Leu Ser Leu Asn Glu Lys Tyr Glu lie Ile Phe Pro Phe Tyr Val Gin 115 120 125 Asp Ser Val Ser Gly Ile Trp Val Ser Ala Asp Ile Ala Ser Gly Lys 130 135 140 Asp Gin Lys Tyr Lys Ile Lys Asn Met Ser Ala Ser Gly Cys Ser Ile- 145 150 155 160 Asp Asn Pro Ile Trp His Val Asn Ala Thr Ser Gly Ser Phe Asn Met 165 170 175 Gin Lys Ser His Leu Ser Met Trp Asn Pro Lys Ile Tyr Val Gly Asp 180 185 190 Ile Pro Val Leu Tyr Leu Pro Tyr Ile Phe Met Ser Thr Ser Asn Lys 195 200 205 Arg Thr Thr Gly Phe Leu Tyr Pro Glu Phe Gly Thr Ser Thr 210 215 220 INFORMATION FOR SEQ ID NO:438: SEQUENCE CHARACTERISTICS: LENGTH: 53 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...53 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:438 Met Leu Asp Phe Asp Leu Val Leu Phe Gly Ala Thr Gly Asp Leu Ala 1 5 10 Met Arg Lys Leu Phe Val Ser Leu Tyr Glu Ile Tyr Ile Ser Phe Met 25 Val Leu Lys Thr Ile Leu Gly Leu Ser His Arg Gly Val Arg Ser Tyr 40 Pro Met Lys Ser Phe INFORMATION FOR SEQ ID NO:439: SEQUENCE CHARACTERISTICS: LENGTH: 109 amino acids TYPE: amino acid TOPOLOGY: linear PCTIUS 96/09122 364 (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...109 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:439 Met Gin Asp Leu Pro Pro Cys Pro Lys Arg Asn Asp Ala Tyr Thr Tyr 1 5 10 His Asp Gly Thr Gin Phe Val Cys Ser Ser Cys Leu Tyr Glu Trp Asn 25 Gly Asn Glu Ile Ser Asn Glu Glu Leu Ile Val Lys Asp Cys His Asn 40 Asn Leu Leu Gln Asn Gly Asp Ser Val Ile Leu Ile Lys Asp Leu Lys 55 Val Lys Gly Ser Ser Leu Val Leu Lys Lys Gly Thr Lys Ile Lys Asn 70 75 Ile Lys Leu Val Asn Ser Asp His Asn Val Asp Cys Lys Val Glu Gly 90 Gin Ser Leu Ser Leu Lys Ser Glu Phe Leu Lys Lys Ala 100 105 INFORMATION FOR SEQ ID NO:440: SEQUENCE CHARACTERISTICS: LENGTH: 73 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix).FEATURE: NAME/KEY: misc_feature LOCATION 1...73 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:440 Val Asp Gly Ala Ile Ile Thr Gly Asn Tyr Ala Leu Gin Ala Lys Leu 1 5 10 Thr Gly Ala Leu Phe Ser Glu Asp Lys Asp Ser Pro Tyr Ala Asn Leu 25 Val Ala Ser Arg Glu Asp Asn Ala Gin Asp Glu Ala Ile Lys Ala Leu 40 Ile Glu Ala Leu Gln Ser Glu Lys Thr Arg Lys Phe Ile Leu Asp Thr 55 Tyr Lys Gly Ala Ile Ile Pro Ala Phe INFORMATION FOR SEQ ID NO:441: SEQUENCE CHARACTERISTICS: A A NILIier CUr~tr ~C.TIUS /0c)i 365 LENGTH: 237 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .237 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:441 Val Phe Thr Met Leu Val Leu Val Leu Ser Asp Asn 1 Phe Phe Val1 Ile Leu Phe Leu Ala Pro 145 dly Asp Tyr Pro Gin 225 Ile Trp Met Phe Asn Ilie Aia Thr 130 Leu Aia Leu Val1 Leu 210 Cys Gly Tyr As n Trp As n O iy As n 115 Thr Tyr Phe Lys Cys 195 Tyr His Gdy Lys Thr Giy 70 Tyr G ly Glu Thr Val1 150 Leu Val1 Arg Val1 Asp 230 Val1 Sen Asp 55 Thn Sen Lys Gly Ala 135 Phe Phe Giu Ala Leu 215 Gly Gly Ala 40 Leu Leu Met Ser Pro 120 Giy Giu Giy Tyr Trp 200 Gin Arg Leu As n Gly Gin Leu Aia 105 Thn Val1 Val1 Ala Sen 185 Gly Ile Gin 10 Cys Asn Met Tyr Phe Gin Pro Tyr Gly Se r 170 Thr Leu Pro Ser Se r Ala Leu Lys 75 Tyr Phe Val1 Leu Tyr 155 Met Leu Cys Pro Gly 235 Tyr Sen Met Glu Ile Pro Ser Ile 140 Phe Ala Ser Asp Phe 220 Tyr Phe Leu Ile Gly Val1 Ser Met Ala 125 Ile Ile Leu Gin Arg 205 Leu Tyr Leu Leu Giu Ile Phe Val1 His 110 Leu Arg Ala Val Leu 190 Ala Arg Gly Ile Ala Ile Sen Phe Thr Ile Ala Cys As n 175 Gly Phe Lcu Leu Gly Phe Leu Met Leu Trp His Asn Leu 160 Lys Leu Pro Arg INFORMATION FOR SEQ ID NO:442: SEQUENCE CHARACTERISTICS: LENGTH: 91 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: 71h NAME/KEY: misc-feature AIr-f4F; SFEET /iiS 9 6/ 09 1 2 2 18 DEC 1996 366 LOCATION 1...91 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:442 Val Cys Leu Gly Leu Ala Asp Val Met Val Val Leu Ser Leu His Leu 1 5 10 Asn Leu Asn Pro Thr Asn Pro Lys Trp Leu Asn Arg Asp Arg Leu Val 25 Phe Ser Gly Gly His Ala Ser Ala Leu Val Tyr Ser Leu Leu His Leu 40 Trp Gly Phe Asp Leu Ser Leu Asp Asp Leu Lys Arg Phe Arg Gln Leu 55 His Ser Lys Thr Pro Gly His Pro Glu Leu His His Thr Glu Gly Ile 70 75 Glu Ile Thr Thr Unk Phe Arg Ala Arg Phe Cys INFORMATION FOR SEQ ID NO:442: SEQUENCE CHARACTERISTICS: LENGTH: 91 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...91 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:442 Val Cys Leu Gly Leu Ala Asp Val Met Val Val Leu Ser Leu His Leu 1 5 10 Asn Leu Asn Pro Thr Asn Pro Lys Trp Leu Asn Arg Asp Arg Leu Val 25 Phe Ser Gly Gly His Ala Ser Ala Leu Val Tyr Ser Leu Leu His Leu 40 Trp Gly Phe Asp Leu Ser Leu Asp Asp Leu Lys Arg Phe Arg Gin Leu 55 His Ser Lys Thr Pro Gly His Pro Glu Leu His His Thr Glu Gly Ile 70 75 Glu Ile Thr Thr Unk Phe Arg Ala Arg Phe Cys INFORMATION FOR SEQ ID NO:443: SEQUENCE CHARACTERISTICS: LENGTH: 97 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori a a PCT/US 96/09122 i SPE US i 367 (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...97 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:443 Met Met Ile Thr Lys Gln Ser Tyr Gln Arg Phe Ala Leu Met Arg Val 1 5 10 Phe Val Phe Ser Leu Ser Ala Phe Ile Phe Asn Thr Thr Glu Phe Val 25 Pro Val Ala Leu Leu Ser Asp Ile Ala Lys Ser Phe Glu Met Glu Ser 40 Ala Thr Val Gly Leu Met Ile Thr Ala Tyr Ala Trp Val Val Ser Leu 55 Gly Ser Leu Pro Leu Met Leu Leu Ser Ala Lys Ile Glu Arg Lys Arg 70 75 Leu Leu Leu Phe Leu Phe Ala Leu Phe Ile Phe Ser His Ile Leu Ser 90 Arg INFORMATION FOR SEQ ID NO:444: SEQUENCE CHARACTERISTICS: LENGTH: 280 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...280 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:444 Met Lys Leu Arg Ala Ser Val Leu Ile Gly Val Ala Ile Leu Cys Leu 1 5 10 Ile Leu Ser Ala Cys Ser Asn Tyr Ala Lys Lys Val Val Lys Gin Lys 25 Asn His Val Tyr Thr Pro Val Tyr Asn Glu Leu Ile Glu Lys Tyr Ser 40 Glu Ile Pro Leu Asn Asp Lys Leu Lys Asp Thr Pro Phe Met Val Gin 55 Val Lys Leu Pro Asn Tyr Lys Asp Tyr Leu Leu Asp Asn Lys Gin Val 70 75 Val Leu Thr Phe Lys Leu Val His His Ser Lys Lys Ile Thr Leu Ile 90 Gly Asp Ala Asn Lys Ile Leu Gln Tyr Lys Asn Tyr Phe Gin Ala Asn 100 105 110 Gly Ala Arg Ser Asp Ile Asp Phe Tyr Leu Gin Pro Thr Leu Asn Gin 115 120 125 Lys Gly Val Val Met Ile Ala Ser Asn Tyr Asn Asp Asn Pro Asn Asn 130 135 140 Lys Glu Lys Pro Gln Thr Phe Asp Val Leu Gin Gly Ser Gin Pro Met 145 150 155 160 T Leu Gly Ala Asn Thr Lys Asn Leu His Gly Tyr Asp Val Ser Gly Ala 165 170 175 o.D PCT/US.9bflJullee 1 .NS 18 DEC11996 As n Lys Tyr 210 As n Phe Giu Arg Lys Ile 195 Thr Arg Lys Lys Ser 275 Gin 180 As n Thr Ala Asn Leu 260 Leu Asnf Tyr As n 215 Gin Leu Giu G I y Giu Lys 200 As n Met Asn Arg Lys 280 Val1 185 Thr Gin Arg Met Giu 265 368 Arg Glu Lou Gin Giu Ile 220 Asn Val 235 Ala Lys Giu Tyr Lys Asp 205 Leu Ile Glu Leu Ala 190 Lys Giu Sor Giu Arg 270 INFORMATION FOR SEQ ID NO:445: SEQUENCE CHARACTERISTICS: LENGTH: 187 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1. .187 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:44S Met Thr Thr Pro Met Ile Ilie Ilie Sen Leu Giu Met Giy Leu Ser Leu
I
Val Pro Sen Tnp Lys Phe s0 Ile Ala Asp Asp Thr Val Giy Lou Sen Tyr 130 Asp Phe 145 Tyr Asn Gly Unk Met Asn Ala Arg Tyr Arg Trp 115 G iy Gly Ala Unk 5 Arg Gin Gly Leu Ala Tyr Phe Lys Lou Pro Gly Phe 100 Leu Gly Vai Leu Ph. Leu Unk Thr 165 Phe Giu Cys Gly His Thr 70 Lou Arg Oly Lys Thr 150 Thr Unk Lou Gly His 55 Gin Asn Asn Asp Ala 135 Phe Thr Ala Val1 As n 40 Lou Gly Ser Gly Gly 120 Ala Unk Ala Thr Cys 25 Val1 Gin Gly Thr Ser 105 Ile Lys Thr Asn Trp 185 10 Gin Arg Ly's Tyr Phe 90 Ile Phe Met Pro Ph.
170 Arg Ala Asn Tyr Ile 75 Tyr Thr Thr Arg Thr Lys Ala Lou Thr Lou Phe Met Pro Unk Lou 140 Arg Asp Ala Lys Lou Arg Gly Lys Ser 125 Ala Gly Tyr Ang Val1 Ile Tyr Gly Asp 110 Thr Trp Ser Unk Ser Tyr Asp Asn Val1 Giu Giu Phe Phe Val 175 Ile Gly Lou Thr Thr Phe Lou Phe Ph.
160 Val INFORMATION FOR SEQ ID NO:445: SEQUENCE CHARACTERISTICS: A&Acmnrn q 4 r--T 7 S 96/09122 VPEA/US 996 369 LENGTH: 187 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...187 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:445 Met Thr Thr Pro Met Ile Ile Ile Ser Leu Glu Met Gly Leu Ser Leu 1 5 10 Val Pro Met Arg Gln Cys Leu Val Cys Gln Ala Leu Ala Arg Ser Ile 25 Ser Trp Asn Gly Leu Gly Gly Asn Val Arg Asn Thr Lys Val Tyr Gly 40 Lys Phe Ala Ala Tyr His His Leu Gin Lys Tyr Leu Leu Ile Asp Leu 55 Ile Ala Arg Phe Lys Thr Gln Gly Gly Tyr Ile Phe Arg Tyr Asn Thr 70 75 Asp Asp Tyr Leu Pro Leu Asn Ser Thr Phe Tyr Met Gly Gly Val Thr 90 Thr Val Arg Gly Phe Arg Asn Gly Ser Ile Thr Pro Lys Asp Glu Phe 100 105 110 Gly Leu Trp Leu Gly Gly Asp Gly Ile Phe Thr Unk Ser Thr Glu Leu 115 120 125 Ser Tyr Gly Val Leu Lys Ala Ala Lys Met Arg Leu Ala Trp Phe Phe 130 135 140 Asp Phe Gly Phe Leu Thr Phe Unk Thr Pro Thr Arg Gly Ser Phe Phe 145 150 155 160 Tyr Asn Ala Unk Thr Thr Thr Ala Asn Phe Lys Asp Tyr Unk Val Val 165 170 175 Gly Unk Unk Phe Glu Unk Ala Thr Trp Arg Ala 180 185 INFORMATION FOR SEQ ID NO:446: SEQUENCE CHARACTERISTICS: LENGTH: 58 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...58 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:446 /et Trp Leu Asp His Ile Ala Lys Glu Ile Arg Ser Leu Val Glu Asn 10 AMENDED SH! PCT p 0 9 122 370 Asp Ile Glu Val Gly Ile Val Ile Gly Gly Gly Asn Ile Ile Arg Gly 25 Val Ser Ala Ala Leu Gly Gly Ile Ile Arg Arg Thr Ser Gly Asp Tyr 40 Met Gly Met Leu Ala Thr Val Ile Lys Arg INFORMATION FOR SEQ ID NO:447: SEQUENCE CHARACTERISTICS: LENGTH: 85 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...85 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:447 Val His Asn Phe His Trp Asn Val Lys Gly Thr Asp Phe Phe Asn Val 1 5 10 His Lys Ala Thr Glu Glu Ile Tyr Glu Gly Phe Ala Asp Met Phe Asp 25 Asp Leu Ala Glu Arg Ile Val Gin Leu Gly His His Pro Leu Val Thr 40 Leu Ser Glu Ala Ile Lys Leu Thr Arg Val Lys Glu Glu Thr Lys Thr 55 Ser Phe His Ser Lys Asp Ile Phe Lys Glu Ile Leu Glu Asp Tyr Lys 70 75 His Leu Glu Lys Glu INFORMATION FOR SEQ ID NO:448: SEQUENCE CHARACTERISTICS: LENGTH: 90 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION 1...90 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:448 Met Asn Lys Thr Ile Lys Ala Ala Ala Leu Ala Tyr Asn Met Gly Gin 10 sp His Ala Pro Lys Val Ile Ala Ser Gly Val Gly Glu Val Ala Lys AsartanCM Q14rrT* PCT/US 9 6 uI
'PEANUS
0 I f 371 25 Arg Ile Ile Gln Lys Ala Lys Glu Tyr Asp Ile Ala Leu Phe Ser Asn 40 Pro Met Leu Val Asp Ser Leu Leu Lys Val Glu Leu Asp Cys A'a Ile 55 Pro Glu Glu Leu Tyr Glu Ser Val Val Gln Val Phe Leu Trp Leu Asn 70 75 Ser Val Glu Asn Asn Ala Gln Met Ser Lys INFORMATION FOR SEQ ID NO:449: SEQUENCE CHARACTERISTICS: LENGTH: 104 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...104 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:449 Met Gln Ala Leu Lys Ser Leu Leu Glu Val Ile Thr Lys Leu Gln Asn 1 5 10 Leu Gly Gly Tyr Leu Met His Ile Ala Ile Phe Ile Ile Phe Ile Trp 25 Ile Gly Gly Leu Lys Phe Val Pro Tyr Glu Ala Glu Gly Ile Ala Pro 40 Phe Val Unk Asn Ser Pro Phe Phe Ser Phe Met Tyr Lys Phe Glu Lys 55 Pro Ala Tyr Lys Gln His Lys Met Ser Glu Ser Gln Ser Met Gln Glu 70 75 Glu Met Gln Asp Asn Pro Lys Ile Val Glu Asn Lys Unk Trp His Lys 90 Glu Asn Arg Thr Ser Phe Ser Gly 100 INFORMATION FOR SEQ ID NO:449: SEQUENCE CHARACTERISTICS: LENGTH: 104 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...104 A28C%1M?!M OW!eV PGTUS 96/0912 IPEA'US 18 DEC 1995 372 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:449 Met Gin Ala Leu Lys Ser Leu Leu Glu Val Ile Thr 1 5 Leu Gly Giy Tyr Leu Met His Ile Ala Ile Phe Ilie Ile Gly Gly Leu Lys Ph. Val Pro Tyr Giu Ala Giu Ph. Val Unk Asn Ser Pro Ph. Phe Ser Phe Met Tyr s0 55 Pro Ala Tyr Lys Gin His Lys Met Ser Glu Ser Gin 70 Giu Met Gin Asp Asn Pro Lys Ile Val Giu Asn Lys Giu Asrn Arg Thr Ser Phe Ser Gly 100 INFORMATION FOR SEQ ID NO:450: SEQUENCE CHARACTERISTICS: LENGTH: 172 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc-feature LOCATION I1.. .172 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:450 Met Gly Lys Ile Ser Ala His Leu Ala His Giu Ile 1 Gly Ser Lys Thr Glu Arg so Asn Arg Ala Leu Phe Sern Leu Gin Giu Ser 130 Phe Ile 145 Sen Ala Ile Lys Ile Thr Asn Asp Asn 115 Giu Val1 Leu 5 Ser Leu Pro Ile Ile Lys Lys Gin Cys Tyr Giu Giu 100 Ph. Leu Gin Giy Ph. Thr Phe Glu 165 Leu Ala Val Val Ala Thr 55 Ser Leu 70 Thn Tyr Gly Phe Tyr Asn Gin Val 135 Ile Ile 150 Pro Ph.
Ser Giu 40 Leu Lys Ser Ph.
Ala 120 Lys Asp G lu Val1 25 Leu Leu Thr Lys Asp 105 Ile Ile Asn Thr Leu Gin Phe Leu Asp 90 Ph.
Asp Giu Gly Leu Lys Sen Giu 75 Ile Asp Ala Ala Lys 155 Lys Ala Lys Ser Asp Leu Ile Ph.
140 Glu Ang His Leu Gly Asp Ph.
Met Giu 125 Ile Val1 Asn Ala Trp Ile Leu Leu Gly 110 Ala Gin Glu Pro Asn Ang Gin Lys Ph.
Ile Leu Msn Astn Vali Glu Val1 Ala Glu Asn Val1 Giu Giu Lys 160 Thr Lys Leu 170 2) INFORMATION FOR SEQ ID NO:451: S SEQUENCE CHARACTERISTICS: AMFtfl~n SHEETI 373 LENGTH: 212 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...212 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:451 Val Ser Glu Phe His Gin Val Tyr Asp Pro Leu Gly Asn Ile Trp Leu 1 5 10 Ser Ala Leu Val Ala Leu Leu Pro Ile Leu Leu Phe Phe Leu Ser Leu 25 Met Val Phe Lys Leu Lys Gly Tyr Thr Ala Ala Phe Leu Ser Val Ala 40 Leu Ser Ala Ile Ile Ala Val Leu Val Tyr Lys Met Pro Val Ser Met 55 Val Gly Ser Ser Phe Leu Tyr Gly Phe Leu Tyr Gly Leu Trp Leu Phe 70 75 Ala Trp Ile Ile Ile Ala Ala Ile Phe Leu Tyr Lys Leu Ser Val Lys 90 Ser Gly Tyr Phe Glu Ile Leu Lys Glu Ser Val Gin Ser Ile Thr Leu 100 105 110 Asp His Arg Ile Leu Val Ile Leu Ile Gly Phe Cys Phe Gly Ser Phe 115 120 125 Leu Glu Gly Ala Ile Gly Phe Gly Gly Pro Ile Ala Ile Thr Ala Ala 130 135 140 Ile Leu Val Gly Leu Gly Leu Ser Pro Leu Tyr Ser Ala Gly Leu Cys 145 150 155 160 Leu Ile Ala Asn Thr Ala Pro Val Ala Phe Gly Ala Val Gly Ile Pro 165 170 175 Ile Ser Ala Met Ala Ser Ala Val Gly Val Pro Ala Ile Leu Ile Ser 180 185 190 Ala Met Thr Gly Lys Ile Leu Phe Phe Val Ser Leu Leu Val Pro Phe 195 200 205 Phe Ile Val Phe 210 INFORMATION FOR SEQ ID NO:452: SEQUENCE CHARACTERISTICS: LENGTH: 182 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_ feature N. LOCATION 1...182 AMENDED
SHEETI
V~s96~9z 374 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:452 Met Glu Ile Lys Met Ala Lys Asp Tyr Gly Phe Cys
I
Arg Ser Asn Val1 Lys Lys Val1 Tyr Giu 145 Ala Thr Ala Leu Val1 Ile As n Pro Leu Ala 130 Lys As n Glu Ile -Ile Lys Ile Lys Gin Phe 115 Thr Lys Pro Val1 Gin His Ile Arg Giy Gin 100 Giy As n Leu Lys Arg 180 5 Ile Asnf G iu Thr Val1 Ile Asp Gin Gin Thr 165 Ile Ala Aia Giu His 70 Lys Val1 Ile Aia Arg 150 Leu Phe Giu Lys Asp 55 Gly Ile Giu As n Leu 135 Lys Ala Lys Giu 40 Pro Ile Thr Ser His i2 0 Val1 Val1 Asn Asn 25 Ile Lys Pro Asp Met 105 Pro Gly Ala Arg 10 Gin Asn Lys Lys Ala 90 Ser G iu Asn Leu Phe 170 Asn Arg Ile Gin 75 Thr Lys Val1 Ser Val1 Leu Ser Leu Pro Asp Cys G iu Lys Leu 140 Ser Phe Phe Leu Giu Lys Leu Pro Gly Gly 125 Giu Gin G iy Gly Ile Lys As n Giu Tyr Tyr 110 Val1 Giu Thr Gly Vai Lys Phe Gly Asn Phe Lys Ser Tyr Leu Val Ile Gin Ile Ile Ser Leu Gin Thr Gin 160 Unk Cys 175 INFORMATION FOR SEQ ID NO:453: SEQUENCE CHARACTERISTICS: LENGTH: 224 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc..teature LOCATION .224 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:453 Met Asp His Giu Phe Leu Ile Thr Met Arg Leu 1 5 i0 Leu Ile Thr Thn Leu Ile Leu Leu Pro Ile Gly 25 Phe Leu Ser Leu Lys Arg Asn Leu Leu Thr Ser 40 Val Tyr Met Pro Leu Val Leu Pro Pro Sen Val 55 Leu Leu Ile Phe Ser Pro Sen Ser Phe Leu Giy 70 75 Val Leu Asn Vai Lys Leu Vai Phe Ser Phe Gin 90 Sen Val Ilie Phe Sen Leu Pro Phe Met Val Sen 100 105 Leu Ilie Ser Leu Pro Thr Ser Leu Lys Giu Ala 115 120 1LYs Gly Giu Tyr Tyr Thr Leu Phe Phe Vai Leu Ser Ile Leu Leu Ala Gly Pro Ser Leu Ph.
Ph.
Thr Gly Phe Leu Ile Tyr 125 Pro Ser Leu Ala Leu Giy Tyr Giu Thr Leu Phe Tyr Leu Leu Gin Asp Ile Leu Gly Lys Ser Aia 110 Sen Leu Gly Asn Ile Lys 375 130 135 140 Pro Ser Val Leu Met Ala Ile Ile Thr Thr Phe Met His Thr Ile Gly 145 150 155 160 Glu Phe Gly Val Val Met Met Leu Gly Gly Asp Ile Leu Gly Glu Thr 165 170 175 Arg Val Ala Ser Ile Thr Ile Phe Asn Glu Ala Glu Ala Leu Asn Tyr 180 185 190 Ser Lys Ala His Gln Tyr Ala Leu Thr Leu Thr Leu Ile Ser Phe Ser 195 200 205 Leu Leu Phe Val Thr Leu Phe Leu Asn Lys Lys Gln Ser Ser Phe Leu 210 215 220 INFORMATION FOR SEQ ID NO:454: SEQUENCE CHARACTERISTICS: LENGTH: 131 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...131 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:454 Met His Pro Ile Met Phe Ala Tyr Ile Ala Asn Ala Leu Ala Gln Ala 1 5 10 Arg Lys Ile Asn Gly Thr Leu Cys Met Ala Phe Gln Lys Ile Ser Gin 25 Val Lys Glu Leu Gly Ile Asp Lys Ala Lys Ser Leu Ile Gly Asn Leu 40 Ser Giln Val Ile Ile Tyr Pro Thr Lys Asp Thr Asp Glu Leu Ile Glu 55 Cys Gly Val Pro Leu Ser Asp Ser Glu Ile Asn Phe Leu His Asn Thr 70 75 Asp Met Arg Ala Arg Gln Val Leu Val Lys Asn Ile Val Thr Asn Ala 90 Ser Ala Phe Ile Glu Ile Asp Leu Lys Lys Ile Cys Lys Asn Tyr Phe 100 105 110 Ile Phe Leu Ile Ala Met Leu Val Ile Glu Lys Ser Ser Met Ile Leu 115 120 125 Lys Lys Gin 130 INFORMATION FOR SEQ ID NO:455: SEQUENCE CHARACTERISTICS: LENGTH: 73 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein N (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: AMENDED SHEET Pouv 96/09122 376 ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...73 (xi)-SEQUENCE DESCRIPTION: SEQ ID NO:455 Cys Leu Thr Gly Gly Leu Met Arg Trp Leu Lys Ser Val Lys Pro 5 10 Arg Ile Leu His Ser Val Val Glu Phe Val Asp Ile Ala Gly Leu 25 Lys Gly Ala Ser Lys Gly Glu Gly Leu Gly Asn Gin Phe Leu Ala 40 Ile Lys Glu Cys Glu Val Ile Leu Gin Val Val Arg Cys Phe Glu 55 Asp Asn Asn His Ala Cys Glu Arg Met 1 Glu Ile Asn Asp INFORMATION FOR SEQ ID NO:456: SEQUENCE CHARACTERISTICS: LENGTH: 92 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION 1...92 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:456 Met His Val Ala Cys Leu Leu Ala Leu Gly Asp Asn Leu Ile Thr 1 5 10 Ser Leu Leu Lys Glu Ile Ala Ser Lys Gin Gin Gin Ser Leu Lys 25 Leu Gly Thr His Leu Thr Leu Lys Ile Ala Lys Leu Leu Glu Cys 40 Lys His Phe Glu Ile Ile Pro Val Phe Glu Asn Ile Pro Ala Phe 55 Asp Leu Lys Lys Gin Gly Val Phe Trp Ala Met Lys Asp Phe Leu 70 75 Leu Leu Lys Gin Leu Lys Asn Ile Lys Ser Asn Val Leu Ile Glu Tyr Trp INFORMATION FOR SEQ ID NO:457: SEQUENCE CHARACTERISTICS: LENGTH: 205 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES All ofpalw~I-y 0% 11- PCT/US 9 /0 a 377 (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc feature LOCATION 1...205 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:457 Met Lys Lys Lys Pro Leu Met Trp Arg Ile Cys Ala Leu Arg Arg Leu 1 5 10 Leu Leu Gly Phe Lys Arg Glu Arg Glu Leu Leu Ser Phe Ala Lys His 25 Trp Asn Ile Pro Thr Ile Val Val Phe Thr His Thr Gln Ala Glu Ala 40 Gly Asp Ala Phe Val Gln Glu Thr Lys Gly Ile Ile Asp Glu Glu Trp 55 Gly Phe Lys Gly Phe Val Arg Ala Tyr Val Arg Val Asn Ser Val Ala 70 75 Phe Ser Phe Arg Gly Leu Lys Val Pro Val Glu Gly Leu Glu Glu Leu 90 Val Asp Glu Thr Lys Lys Cys Leu Ser Asp Ala Glu Lys Asn Lys Lys 100 105 110 Arg His Phe Leu Ser Ile Gln Arg Val Lys Ile Gln Glu Arg Lys Gin 115 120 125 Ala Met Ile Glu Glu Cys Lys Thr Ile Ile His Val Ala Ser Gly Ala 130 135 140 Ala Gly Val Ala Gly Leu Ile Pro Ile Pro Phe Ser Asp Ala Leu Ala 145 150 155 160 Ile Ala Pro Ile Gln Ala Gly Met Ile Tyr Lys Met Asn Asp Ala Phe 165 170 175 Gly Met Asp Leu Asp Lys Ser Val Gly Ala Ser Leu Val Ala Gly Leu 180 185 190 Leu Gly Val Asn Cys Arg Ala Ser Gly Glu Asp Ser Arg 195 200 205 INFORMATION FOR SEQ ID NO:458: SEQUENCE CHARACTERISTICS: LENGTH: 41 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_ feature LOCATION 1...41 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:458 Val Leu Gly Val Unk Asn Leu Arg Gly Asn Val Phe Pro Leu Ile Ser 1 5 10 Leu Arg Leu Lys Phe Gly Leu Lys Ala Glu Lys Gln Asn Lys Asp Thr 25 Arg Tyr Leu Val Val Arg His Asn Asp PCT/US 96/09122 378 INFORMATION FOR SEQ ID NO:459: SEQUENCE CHARACTERISTICS: LENGTH: 219 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...219 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:459 Val Lys Ser Val Phe Ser Glu Glu Lys Glu Thr Pro Val Thr Lys Glu 1 5 10 Asn Gly Ser Tyr Leu Ile Ala Tyr Asp Pro Leu Asp Gly Ser Ser Val 25 Met Glu Ala Asn Phe Leu Val Gly Thr Ile Ile Gly Val Tyr Glu Lys 40 Asp Tyr Lys Ala Gln Asn Leu Val Ala Ser Leu Tyr Val Val Phe Gly 55 His Lys Ile Glu Leu Val Val Ala Leu Glu Giu Val Tyr Arg Tyr Ala 70 75 Phe Tyr Gln Asn Lys Phe His Phe Ile Glu Thr Ile Val Leu Glu Asn 90 Lys Gly Lys Ile Ile Ala Ser Gly Gly Asn Gin Lys Asp Phe Ser Leu 100 105 110 Gly Leu Lys Lys Ala Leu Glu Gly Phe Phe Ala Glu Asn Tyr Arg Leu 115 120 125 Arg Tyr Ser Gly Ser Met Val Ala Asp Val His His Val Leu Val Lys 130 135 140 Lys Gly Gly Met Phe Ser Tyr Pro Gin Lys Lys Leu Arg Lys Leu Phe 145 150 155 160 Glu Val Phe Pro Leu Ala Leu Met Val Glu Lys Ala Lys Gly Glu Ala 165 170 175 Phe Tyr Phe Asp Lys Gly Val Lys Lys Arg Leu Leu Asp Gin Ser Val 180 185 190 Glu Ser Tyr His Glu Lys Ser Glu Cys Tyr Leu Ala Ser Pro His Glu 195 200 205 Ala Gin Ile Leu Giu Lys His Leu Lys Gly Glu 210 215 INFORMATION FOR SEQ ID NO:460: SEQUENCE CHARACTERISTICS: LENGTH: 188 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: R(A) ORGANISM: Helicobacter pylori I (ix) FEATURE: AISIMM e enCUCET PCTUS 96/091 IPLA/US 10 'i w6 379 NAME/KEY: misc -feature LOCATION .188 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:460 Met Lys Ser Ile Giy Glu Val Met Ala Ile Gly Gly 1 Ala Glu Pro Val1 Leu Se r Phe Giu Ala 145 Leu Leu Gln Leu Pro Val1 Gin Leu Asp 115 Ser His Leu Thr Lys Ser Lys Asp Ile Thr 100 Ala Pro Phe Ile Asn 180 5 Ala Lys Arg Giu Gin Asp Arg Phe Glu Cys 165 Lys Ser Giu 40 Tyr Giu Val1 Lys Thr 120 Giu Asp Pro Lys Leu 25 Ala Ile Leu Lys Leu 105 Lys Leu Thr Met Lys 185 Giu Ile Ala Cys Ala Arg Ile Ala Cys Pro 170 Arg Asa Asn Lys Lys Asp Ala Gin Ile 75 Giu Giu Gly Leu Lys Giu Arg Ser 140 Ala Aia 155 Leu Thr Lys Ser Asa Trp Glu Phe Asp Gly Lys Asn 125 Asn Glu Leu Phe Leu Ile Arg Arg Ile Asan 110 Giu Leu Phe Cys Giu Phe Arg Gly Phe Ser Gly Leu Ile Ser 160 Leu INFORMATION FOR SEQ ID NO:461: SEQUENCE CHARACTERISTICS: LENGTH: 231 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .231 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:46i Phe Gly Asn Lys Gin Leu Gin Leu Gin Ile 10 1 Ile Ala Glu Leu Lys Lys Giu Val Asa Leu 25 i Leu Cys Leu His Giu Gly Phe Val Gly Ile 40 1 Phe Lys Sen Gly Asa Leu Aia Ser Leu Asn 55 Val His Phe Lys Glu Asa Ala Giu Ser Val 70 75 Tyr Ser Leu Lys Ser Gin Asn Ile Asp Gly 90 *i Ala Lys Lys Thr Gly Gly Val Gly Glu Tyr 100 105 Met GlI Asr Va Se: Se: Le Ser Tyr Lys Asn Asa Val1 His Gin Gin Asa Leu Leu Gin Lys Lys Asp Ser is Ser Leu Leu Asa Lys Val Giu Glu Gin Gin Gly Vai Tyr Phe Sen Asn Asp Leu 110 011 AMFeOEDSHEETi PCT/US 9 6 09 122 WEA/US 16 Jr.. 380 Phe Lys Thr Phe Cys Thr Ser Leu Lys Glu Gly Leu Glu Asn Ala Gin 115 120 125 Glu Ser Met Gln Tyr Phe His Gin Glu Thr Gly Leu Leu Leu Asn Ala 130 135 140 Ala Lys Asn Gly Glu Glu His Ser Asn Glu Gly Leu Ile Thr Val Asn 145 150 155 160 Lys Thr Gly Gin Asp Ile Glu Ser Leu Tyr Glu Lys Met Gin Asn Ala 165 170 175 Thr Ser Leu Ala Asp Ser Leu Asn Gln Arg Ser Asn Glu Ile Thr Gin 180 185 190 Val Ile Ser Leu Ile Asp Asp Ile Ala Glu Gin Thr Asn Leu Leu Ala 195 200 205 Leu Asn Ala Ala Ile Glu Ala Ala Arg Ala Val Asn Met Ala Glu Gly 210 215 220 Leu Arg Trp Trp Leu Met Arg 225 230 INFORMATION FOR SEQ ID NO:462: SEQUENCE CHARACTERISTICS: LENGTH: 63 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...63 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:462 Met Trp Ile Met Ser Ser Leu Ser Ser Ser Phe Phe His Ser Leu Phe 1 5 10 Phe Ile Lys Ser Asn Pro Gly Gin Leu Leu Lys Gly Trp Gly Ser Lys 25 Ile Phe Phe Ile Asn Arg Lys Phe Val Leu Ala Gin Tyr Asn Pro Ser 40 Val Ser Ile Phe Ile Leu Leu Asn Arg Val Phe Gly Val Gly Val 55 INFORMATION FOR SEQ ID NO:463: SEQUENCE CHARACTERISTICS: LENGTH: 182 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...182 PGTUS 96,5:> 381 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:463 Met Gln Phe Glu Glu Met Lys Giu Leu Ala His Gln Ile Gly Val Phe 1 5 10 Tyr His Val Gly Val Asp Gly Ile Ala Leu Phe Leu Leu Leu Leu Asn 25 Ala Ile Val Val Leu Leu Ser Val Val Tyr Val Lys Glu Arg Arg Lys 40 Asp Phe Val Ile Cys Leu Leu Leu Leu Unk Gly Ile Leu Met Gly Val 55 Phe Ser Ser Leu Asn Val Ile Phe Phe Tyr Ala Phe Trp Glu Ile Ser 70 75 Leu Leu Pro Val Leu Tyr Leu Ile Gly Arg Phe Gly Arg Asn Asn Lys 90 Ile Tyr Ser Gly Met Lys Phe Phe Leu Tyr Thr Phe Leu Ala Ser Leu 100 105 110 Cys Met Leu Leu Gly Ile Leu Tyr Ile Gly Tyr Asp Tyr Ala Asn Asn 115 120 125 Tyr Gly Met Met Ser Phe Asp Ile Leu Asp Trp Tyr Gln Leu Asn Phe 130 135 140 Ser Ser Gly Ile Lys Thr Trp Leu Phe Val Ala Phe Leu Ile Gly Ile 145 150 155 160 Ala Val Lys Ile Pro Leu Phe Pro Phe Thr His Gly Cys Leu Met Arg 165 170 175 Ile Leu Thr Pro Pro Leu 180 INFORMATION FOR SEQ ID NO:463: SEQUENCE CHARACTERISTICS: LENGTH: 182 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...182 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:463 Met Gln Phe Glu Glu Met Lys Glu Leu Ala His Gin Ile Gly Val Phe 1 5 10 Tyr His Val Gly Val Asp Gly Ile Ala Leu Phe Leu Leu Leu Leu Asn 25 Ala Ile Val Val Leu Leu Ser Val Val Tyr Val Lys Glu Arg Arg Lys 40 Asp Phe Val Ile Cys Leu Leu Leu Leu Unk Gly Ile Leu Met Gly Val 55 Phe Ser Ser Leu Asn Val Ile Phe Phe Tyr Ala Phe Trp Glu Ile Ser 70 75 Leu Leu Pro Val Leu Tyr Leu Ile Gly Arg Phe Gly Arg Asn Asn Lys 90 Ile Tyr Ser Gly Met Lys Phe Phe Leu Tyr Thr Phe Leu Ala Ser Leu 100 105 110 Cys Met Leu Leu Gly Ile Leu Tyr Ile Gly Tyr Asp Tyr Ala Asn Asn 115 120 125 AMENDED SHEET4 PCT/US 9 6 09 382 Tyr Gly Met Met Ser Phe Asp Ile Leu Asp Trp Tyr Gln Leu Asn Phe 130 135 140 Ser Ser Gly Ile Lys Thr Trp Leu Phe Val Ala Phe Leu Ile Gly Ile 145 150 155 160 Ala Val Lys Ile Pro Leu Phe Pro Phe Thr His Gly Cys Leu Met Arg 165 170 175 Ile Leu-Thr Pro Pro Leu 180 INFORMATION FOR SEQ ID NO:464: SEQUENCE CHARACTERISTICS: LENGTH: 116 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...116 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:464 Val Lys Lys Tyr Ala Glu Asp Phe Ile Thr Lys Asp Glu Val Lys Ser 1 5 10 Leu Leu Glu Arg Leu Ala Lys Asp Tyr Pro Thr Ile Val Glu Glu Ser 25 Lys Lys Ile Pro Thr Gly Ala Ile Arg Ser Val Leu Gln Ala Leu Leu 40 His Glu Lys Ile Pro Ile Lys Asp Met Leu Thr Ile Leu Glu Thr Ile 55 Thr Asp Ile Ala Pro Leu Val Gln Asn Asp Val Asn Ile Leu Thr Glu 70 75 Gin Val Arg Ala Arg Leu Ser Arg Val Ile Thr Asn Ala Phe Lys Ser 90 Glu Asp Gly Arg Leu Lys Phe Leu Thr Phe Ser Thr Asp Unk Glu Gin 100 105 110 Phe Unk Ala Gin 115 INFORMATION FOR SEQ ID NO:464: SEQUENCE CHARACTERISTICS: LENGTH: 116 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc feature LOCATION 1...116
-':IE
P 7 96/09 1.
DEC 1996 383 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:464 Val Lys Lys Tyr Ala Glu Asp Phe Ile Thr Lys Asp Glu Val Lys Ser 1 5 10 Leu Leu Glu Arg Leu Ala Lys Asp Tyr Pro Thr Ile Val Glu Glu Ser 25 Lys Lys Ile Pro Thr Gly Ala Ile Arg Ser Val Leu Gin Ala Leu Leu 40 His Glu Lys Ile Pro Ile Lys Asp Met Leu Thr Ile Leu Glu Thr Ile 55 Thr Asp Ile Ala Pro Leu Val Gin Asn Asp Val Asn Ile Leu Thr Glu 70 75 Gin Val Arg Ala Arg Leu Ser Arg Val Ile Thr Asn Ala Phe Lys Ser 90 Glu Asp Gly Arg Leu Lys Phe Leu Thr Phe Ser Thr Asp Unk Glu Gin 100 105 110 Phe Unk Ala Gin 115 INFORMATION FOR SEQ ID NO:465: SEQUENCE CHARACTERISTICS: LENGTH: 153 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...153 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:465 Val Gly Ala Asn Pro Val Pro His Ala Gin Ile Leu Gin Ser Val Val 1 5 10 Asp Asp Leu Lys Glu Lys Gly Ile Lys Leu Val Ile Val Ser Phe Thr 25 Asp Tyr Val Leu Pro Asn Leu Ala Leu Asn Asp Gly Ser Leu Asp Ala 40 Asn Tyr Phe Gin His Arg Pro Tyr Leu Asp Arg Phe Asn Leu Asp Arg 55 Lys Met His Leu Val Gly Leu Ala Asn Ile His Val Glu Pro Leu Arg 70 75 Phe Tyr Ser Gln Lys Ile Thr Asp Ile Lys Asn Leu Lys Lys Gly Ser 90 Val Ile Ala Val Pro Asn Asp Pro Ala Asn Gln Gly Arg Ala Leu Ile 100 105 110 Leu Leu His Lys Gln Gly Leu Ile Ala Leu Lys Asp Pro Ser Asn Leu 115 120 125 Tyr Ala Thr Glu Phe Asp Ile Val Lys Asn Pro Tyr Asn Ile Lys Ile 130 135 140 Lys Pro Leu Glu Ala Ala Val Ile Ala 145 150 INFORMATION FOR SEQ ID NO:466: AiAmrkFf SHEET 384 SEQUENCE CHARACTERISTICS: LENGTH: 43 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...43 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:466 Met Gly Leu Val Ala Ser Gly Ile Asn Asp Glu Glu Leu Leu Lys Trp 1 5 10 Leu Gln Ala Phe Gly Leu Lys Met Gly Leu Cys Phe Gln Val Leu Asp 25 Asp Ile Ile Asp Val Thr Gln Asp Glu Lys Glu INFORMATION FOR SEQ ID NO:467: SEQUENCE CHARACTERISTICS: LENGTH: 240 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...240 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:467 Met Met Lys Asn Lys Arg Ser Gin Asn Ser Pro Tyr Val Thr Pro Asp 1 5 10 Asn Pro Tyr Leu Thr Leu Glu Lys Ala Leu Gly Tyr Ser Phe Lys Asp 25 Lys Arg Leu Leu Glu Gin Ala Leu Thr His Lys Ser Cys Lys Leu Ala 40 Leu Asn Asn Glu Arg Leu Glu Phe Leu Gly Asp Ala Val Leu Gly Leu 55 Val Ile Gly Glu Leu Leu Tyr His Lys Phe Unk Unk Unk Asp Gly Gly 70 75 Lys Leu Ser Lys Leu Arg Ala Ser Ile Val Ser Ala His Gly Phe Thr 90 Lys Leu Ala Lys Ala Ile Ala Leu Gln Asp Tyr Leu Arg Val Ser Ser 100 105 110 Ser Glu Glu Ile Ser Lys Gly Arg Glu Lys Pro Ser Ile Leu Ser Ser 115 120 125 Ala Phe Glu Ala Leu Met Ala Gly Val Tyr Leu Glu Ala Gly Leu Ala 130 135 140 Lys Val Arg Lys Ile Ile Gln Asn Leu Leu Asn Arg Ala Tyr Lys Arg PCT/US 96/9L 145 Leu Leu Giu Gin Giu 225 150 Leu Giu His Leu Phe Met Asp Tyr 165 170 Gin Unk Gin Phe Cys Val Ile Pro 180 185 Gly Pro Asp His His Lys Giu Phe 195 200 Lys Met Tyr Ala Thr Ala Lys Gly 215 Gin Cys Ala Tyr Gin Ala Leu Gin 230 155 Lys Thr Ala Leu Gin 175 Thr Tyr Gin Leu Leu 190 Giu Met Ala Leu Tyr 205 Lys Ser Lys Lys Glu 220 Asn Leu Arg Lys Pro 235 160 GiU Gin Ile Ala As n 240 INFORMATION FOR SEQ ID NO:467: SEQUENCE CHARACTERISTICS: LENGTH: 240 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .240 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:467 Met Met Lys Asn Lys Arg Ser Gin Asn Ser Pro Tyr Val Thr 1 Asn Lys Leu Val1 Lys Lys Sen Ala Lys 145 Leu Leu Glu GIn Pro Arg Asn Ile Leu Leu Glu Phe 130 Val1 Asp Thr Lys Asp 210 Tyn Leu Asn C ly Sen Ala Giu 115 Giu Ang Leu Gin C ly 195 Lys Leu Leu Giu Glu Lys Lys 100 Ile Ala Lys Giu Unk 180 Pro Met 5 Thn Giu Ang Leu Leu Ala Sen Leu Ile His 165 Gin Asp Tyr Leu Gin Leu Leu 70 Arg Ile Lys Met Ilie 150 Leu Phe His Ala Tyr 230 :;lu Ala G1u 55 Tyn Ala Ala Gly Ala 135 Gin Phe Cys His Thr 215 Lys Leu 40 Phe His Sen Leu Ang 120 Gly Asn Met Val1 Lys 200 Ala Ala 25 Thr Leu Lys Ile Gin 105 Glu Val Leu Asp Ile 185 Giu Lys Leu His Gly Phe Val1 90 Asp Lys Tyr Leu Tyr 170 Pro Phe C ly Gin Gly Lys Asp Unk 75 Ser Tyr Pro Leu Asn 155 Lys Thr Giu *Lys *Asn 235 T'yr Sen Ala Unk Ala Leu Sen Glu 140 Arg Thr Tyr Met Sen 220 Leu Ser :ys tUnk His Arg Ile 125 Ala Ala Ala Gin Ala 205 Lys Arg Phe Lys Leu Asp Gly Val 110 Leu Gly Tyr Leu *Leu 190 *Leu Lys Lys Pro Lys Leu Gly Gly Phe Scr Sen Leu Lys Gin 175 Leu Tyr Giiu Prc Asp Asp Ala Leu Gly Thr Ala Arg 160 Giu *Gin Sle Ala Asn 240 Giu Gin Gin Cys Ala Gin Ala Leu tw'imnFf SHEET IP S I? DEC 1996 386 INFORMATION FOR SEQ ID NO:468: SEQUENCE
CHARACTERISTICS:
LENGTH: 209 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...209 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:468 Met Gly Phe Asn Arg Leu Val Asp Arg Asp Ile Asp Lys Asp Asn Pro 1 5 10 Arg Thr Lys Asn Arg Pro Ser Val Asp Gly Arg Ile Ser Val Lys Gly 25 Met Val Ile Phe Ser Val Ser Asn Ala Leu Leu Phe Val Gly Val Ser 40 Tyr Phe Ile Asn Pro Leu Ala Phe Lys Leu Ser Leu Pro Phe Leu Ile 55 Ile Leu Gly Gly Tyr Ser Tyr Phe Lys Arg Phe Ser Ser Leu Ala His 70 75 Phe Val Val Gly Leu Ala Leu Gly Leu Ala Pro Ile Ala Gly Ser Val 90 Ala Val Leu Gly Asp Ile Pro Leu Trp Asn Val Phe Leu Ala Leu Gly 100 105 110 Val Met Leu Trp Val Ala Gly Phe Asp Leu Leu Tyr Ser Leu Gln Asp 115 120 125 Met Glu Phe Asp Lys Glu Arg Gly Leu Phe Ser Ile Pro Ser Gln Leu 130 135 140 Gly Glu Lys Trp Cys Leu Asn Leu Ser Arg Leu Ser His Leu Val Ala 145 150 155 160 Leu Ile Cys Trp Leu Cys Phe Val Lys Cys Tyr His Gly Gly Leu Phe 165 170 175 Ala Tyr Leu Gly Leu Gly Val Ser Ala Leu Ile Leu Leu Tyr Glu Gin 180 185 190 Ile Leu Val Ala Arg Asp Tyr Lys Asn Ile Pro Lys Ser Leu Phe Cys 195 200 205 Glu INFORMATION FOR SEQ ID NO:469: SEQUENCE
CHARACTERISTICS:
LENGTH: 95 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: POT/US 96/09 12( 387 NAME/KEY: misc_feature LOCATION 1...95 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:469 Val Glu Gin Asn Lys Ile Ile Lys Leu Phe Thr Val Ala Thr Met Ala 1 5 10 Met Met Pro Pro Thr Leu Ile Gly Thr Ile Asn Gly Met Asn Phe Lys 25 Phe Met Pro Glu Leu Glu Trp Gln Tyr Gly Tyr Leu Phe Ala Leu Ile 40 Val Met Ala Ile Ser Thr Ile Leu Pro Val Ile Tyr Phe Lys Lys Lys 55 Gly Leu Val Val Ala Phe His Gly Ile Phe lie Leu Thr Leu Arg Arg 70 75 Ser Phe Tyr Thr Ala Trp His Ser Leu Leu Gly Tyr Ala Thr Leu 90 INFORMATION FOR SEQ ID NO:470: SEQUENCE
CHARACTERISTICS:
LENGTH: 228 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION 1...228 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:470 Leu Leu Val Leu Leu Asn Leu Lys Unk Thr Pro Asn Leu Met Trp Pro 1 5 10 Leu Asp Ile Ile Val Val Val Ala Trp Val Leu Trp Gly Val Asn Met 25 Phe Gly Ser Met Ser Val Arg Arg Glu Asn Thr Ile Tyr Val Ser Leu 40 Trp Tyr Tyr Ile Ala Thr Tyr Val Gly Ile Ala Val Met Tyr Ile Phe 55 Asn Asn Leu Ser Ile Pro Thr Tyr Phe Val Ala Asp Met Gly Ser Val 70 75 Trp His Unk lie Ser Met Tyr Ser Gly Ser Asn Asp Ala Leu Ile Gin 90 Trp Trp Trp Gly His Asn Ala Val Ala Phe Val Phe Thr Ser Gly Val 100 105 110 Ile Gly Thr Ile Tyr Tyr Phe Leu Pro Lys Glu Ser Gly Gln Pro Ile 115 120 125 Phe Ser Tyr Lys Leu Thr Leu Phe Ser Phe Trp Ser Leu Met Phe Val 130 135 140 Tyr Ile Trp Ala Gly Gly His His Leu Ile Tyr Ser Thr Val Unk Asp 145 150 155 160 Unk Val Gln Thr Leu Ser Ser Unk Phe Ser Val Val Leu Ile Leu Pro 165 170 175 Ser Unk Gly Thr Ala Ile Asn Met Leu Leu Unk Met Arg Gly Gin Trp 180 185 190 His Gin Unk Lys Glu Ser Pro Leu Ile Lys Phe Leu Val Leu Ala Ser 195 200 205 ARwNIn SHEET 388 Thr Phe Tyr Met Leu Ser Thr Leu Glu Gly Ser Ile Gln Ala Ile Lys 210 215 220 Ser Val Asn Ala 225 INFORMATION FOR SEQ ID NO:470: SEQUENCE CHARACTERISTICS: LENGTH: 228 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...228 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:470 Leu Leu Val Leu Leu Asn Leu Lys Unk Thr Pro Asn Leu Met Trp Pro 1 5 10 Leu Asp Ile Ile Val Val Val Ala Trp Val Leu Trp Gly Val Asn Met 25 Phe Gly Ser Met Ser Val Arg Arg Glu Asn Thr Ile Tyr Val Ser Leu 40 Trp Tyr Tyr Ile Ala Thr Tyr Val Gly Ile Ala Val Met Tyr Ile Phe 55 Asn Asn Leu Ser Ile Pro Thr Tyr Phe Val Ala Asp Met Gly Ser Val 70 75 Trp His Unk Ile Ser Met Tyr Ser Gly Ser Asn Asp Ala Leu Ile Gin 90 Trp Trp Trp Gly His Asn Ala Val Ala Phe Val Phe Thr Ser Gly Val 100 105 110 Ile Gly Thr Ile Tyr Tyr Phe Leu Pro Lys Glu Ser Gly Gln Pro Ile 115 120 125 Phe Ser Tyr Lys Leu Thr Leu Phe Ser Phe Trp Ser Leu Met Phe Val 130 135 140 Tyr Ile Trp Ala Gly Gly His His Leu Ile Tyr Ser Thr Val Unk Asp 145 150 155 160 Unk Val Gin Thr Leu Ser Ser Unk Phe Ser Val Val Leu Ile Leu Pro 165 170 175 Ser Unk Gly Thr Ala Ile Asn Met Leu Leu Unk Met Arg Gly Gln Trp 180 185 190 His Gln Unk Lys Glu Ser Pro Leu Ile Lys Phe Leu Val Leu Ala Ser 195 200 205 Thr Phe Tyr Met Leu Ser Thr Leu Glu Gly Ser Ile Gln Ala Ile Lys 210 215 220 Ser Val Asn Ala 225 INFORMATION FOR SEQ ID NO:471: SEQUENCE CHARACTERISTICS: LENGTH: 92 amino acids TYPE: amino acid TOPOLOGY: linear a~ s dE C19912 (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...92 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:471 Phe Asp Ser Ile Val Tyr Phe Phe Asn Lys Ser Gly Phe Val 10 Leu Val Leu Val Trp Ile Ser Leu Tyr Leu Val Met Thr Leu 25 Phe Leu Tyr Lys Ser Ile Val Leu Lys Ile Glu Leu Arg Arg 40 Gin Ser Leu Ser Asn Ile Leu Asn Gly Ala Gin Asp Ala Pro 55 Phe Met Phe Asn Lys Lys Arg Asn Asp Glu Thr Lys Arg Tyr 75 Glu Leu Leu Gin Asp Leu Glu Thr Pro Gly Ser INFORMATION FOR SEQ ID NO:472: SEQUENCE CHARACTERISTICS: LENGTH: 96 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...96 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:472 Met Ala Met Leu Tyr Cys Met Arg Leu Leu Met Pro 1 5 10 Ile Lys Gly Gly Asp Ile Gly Glu Trp Phe Pro Asp 25 Tyr Lys Asn Ala Ser Ser Lys Glu Leu Leu Lys Ile 40 Ser Gin Ser Ile Gly Phe Glu Leu Leu Glu Met Gly 55 Ser Glu Ile Pro Lys Ile Thr Pro Tyr Lys Pro Ala 70 75 Leu Ser Gln Leu Leu Gly Leu Glu Lys Ser Gln Ile 90 INFORMATION FOR SEQ ID NO:473: SEQUENCE CHARACTERISTICS: IN LENGTH: 1178 amino acids Thr Trp Glu Glu Ser Ala Lys Phe Phe Asn Ala lle Asn Val Ala Ile Ser Leu Asp Leu Thr Leu Leu Gly Pro Asp le Glu Lys IP.NUS 18 DEC 1996 390 TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .1178 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:473 Met Ile Pro Asn Leu Asp Ile Glu Gly Giu Thr Met Thr Asn 1 Ile Ile Ser Asn Asn Phe Thr Gin Asn 145 Ile Ala Phe Lys Ile 225 Giu Thr Lei.
Met Asr Se As Ly Asn G Asn A 3 Phe A Arg G Lys A Ile S Gly S Ile 1 130 Thr Ser Phe Met Asn 210 Phe Thr Thr Asp Leu 290 Gin His n Gly s Asn 1n sn 5 sp 1n la er er 115 Phe In Asp Ala Gly 195 Gly Leu Leu Thr Glu 275 Asp Leu Asr Gly G1 5 Gin Pro G Leu Gin V Pro Asn C Ala Phe C 7 Ile Lys 1 Lys Ser I 100 Ser Ile Met Asn Lys Ile Asp Lys 165 Gly Ile 180 Val Phe Giu Pro Ser Phe Asn Gin 245 Thr Asp 260 Arg Gly Val Glu Leu Ile Gly Ile 325 Pro Glu 340 i Arg Gly in I al 1n I Glu 0 Asn Asn Lys rrp Arg 150 Glu Ile Asp Asn Val 230 Glu Ile Asn Gly His 310 Glu Ala Thr Ala Lys 355 Lys Pro Asp Ser Val 135 Gly Lys Ile Glu Gly 215 Phe Pro Gir Phe Va 29 As Pr Ar Glu A 2 Phe I 40 Pro I Ile E Thr I Leu Phe 120 Ser Phe Ala Gly Ser 200 Asp Asn Val Ser Ser 280 1 Ala 5 i Asn o Glu g His la 5e le le LSe ys Ile 105 ;In His Met Glu Asn 185 Leu Pro Lys Pro Leu 265 Lys Asp Al Ly As 34 10 Ala P Lys V Val A Gin L 7 Lys A 90 Asp L Lys E Gin I Glu Phe 170 Gin Lys Thr Lys His 250 Pro Phe Ile t Leu s Val 330 p Trp 5 he al sp eu
L
5 f sn ys Phe Asn Asn 155 Leu Ile G1u Gly Gin 235 Val Prc Th As Se 31 Se As Asn P Asp A 4 Lys A Arg C Gin Asp Gly Asp 140 Ile Arg Arg Arg Gly 220 Ser Gin Glu r Leu p Pro 300 r Ser 5 r Leu n Ala ro G 3 sn V sn A lu G ,yr P Asn L 1 Thr G 125 Pro S Ile C Ser Ser Gin 205 Asp Ser Pro Ala Gly 285 Asn Val Leu Thr in 0 al sp lu he eu ;in er ;ln Ala Asp 190 G1u Trp Asp Asp Arg 270 Asp Ty Le
TY
Va 35 Va Glu A Gin P Val A Arg A Phe A 8 Ser S Ile Arg Lys Pro Lys 175 Gin Ala Leu Leu Val 255 Asp Met r Lys u Met r Gly 335 1 Gly 0 1 His la he la sp la 0 er Asp Tyr Ile Pro 160 GIn Lys Glu Asp Lys 240 Ala Leu Asn Phe Gly 320 Asn Tyr Met Asp Asn Val Ala Thr Leu Ile Asn 360 365 Lys Asn Gly Ser Gly Leu Val Ile Ala Gly Gly Glu Lys Gly le A n 370 375 380 Asn Pro Sen Phe Tyr Leu Tyr Lys Giu Asp Gin Leu Thr Gly Ser GIn p 96 /0912.( 1 8 DEC 1996 385 Arg Phe I Lys C Ala Lys 465 Leu Asp Val Ser Ala 545 Leu Ala Leu Ala Ala 625 Lys Met Leu Gin Ile 705 Asn Leu Lys Asn Ser 785 Asn Gly Leu Ser Gly 865 Ser la Leu Glu Tyr 450 Asp Ser Arg Met Pro 530 G ly Ala Lys Ser la 1 610 31n Asp Glu Ile Asn 690 Asn Gly Lys Val Lys 770 Ile Leu Val Ala Ala 850 Asn Asp Leu S Ala G 4 Lys P 435 Leu A Lys L Tyr T Glu A Phe V 515 Asp L Phe S Ile I Gly 1 Ser 595 Ala C Lys I Val Ala Asn 675 Leu Lys Lys Gly Glu 755 Asp Lys Asn Glu Gin 835 Leu Gly Ile er 1 n 20 he sp ys 'hr la 00 a 1 ys er Thr Leu 580 Asn ;lu Asp Ala Lys 660 Lys Lys Asp Asn Ser 740 Asn Phe Asp Gin Gin 820 Gir Tyrz Leu Ly 3 Gin G 405 Asn A Gin A Ala L His L 4 Leu L 485 Lys Asp Gly Lys Ser 565 Ser I Lys Ala Leu Lys 645 Ser Giu Gly Leu Lys 725 Val Leu Ser Val Ala 805 Ala Ala Gin Ser s Lys 885 90 lu sn sn eu eu 70 ys Thr Tyr Val Val 550 Val Pro Glu Lys lu 630 Asn Gln Ala Ile Lys 710 Asp Lys Asn Lys Ile 790 Val Lev Gir Se Ly 87 G1 GIU I Ala L Glu I 4 Gly A 455 Ala L Asp T Thr L Ser A 5 Gly A 535 Ala V Val A Gin G Leu V 6 Asn T 615 Lys S Leu C Ala I Asn Lys 695 Asp Phe Asp Ala Val 775 Ile Ser Ala Lys Val 855 s Ala 0 u Leu le ys le 40 sn eu yr eu sn 20 la al rg llu al 00 hr er lu Asn Arg 680 Arg Phe Ser Leu Ala 760 Thr Asr Val As As 84 Ly Gl As Gin A 4 Leu A 425 Glu A Asp H Val A Gly L 4 Gin G 505 Phe L Thr A Phe A Gin Ala 585 Gly Gly Leu Ser Ser 665 Asp Glu Ser Lys Gly 745 Leu Gin Gin Ala p Leu 825 i Glu 0 s Asn u Ala n Ala n Ser 905 sn 10 sp sp is la ys 90 ly ys sn sn Asp 570 Asn .ys Asn Lys Lys 650 Gln Ala Leu Lys Ala 730 Ile Asn Ala Lys Lys 810 Lys Asp Gl Th 391 395 Lys V Asn L Phe G Ile A 4 Glu P 475 Lys A Ser L Tyr 1 Gly V 5 Leu P 555 Leu G Lys L Ala L Tyr A 6 Lys A 635 Ser G Lys A Arg A Ser A 7 Ser P 715 Giu C Asn I Glu Lys Ile 795 Ala Asn Phe y Val r Thr 875 al eu 1n la he la eu hr al ro lu eu eu sp rg ly sp la sp 00 he lu Pro ?he Ser 780 rhr Thi Phe As As 86 Le Asp P Ser L 4 Lys A 445 Phe V Gly A Asp L Lys H 5 Asn A 525 Ser H Asn L Asp L Val L 5 Asn P 605 Glu Giu Asn I Glu Ile 685 Lys Asp Thr Giu Lys 765 Asp Asp Gly Ser i Thr 845 n Gly 0 u Ser he M 4 ys L sp S al S sn G ys A 4 is A la S is L eu A ys L 5 ys A he A al Arg Lys Ile 670 Ala Leu Glu Leu Trp 750 Asn Leu Lys Asp Lys 830 Gly Thr Lys et ys er er ly la sp er eu sn eu sp sn Lys Leu Asn 655 ?he yr lu Phe Lys 735 Ile Gly Gu 1 Va Ph 81 Gi1 Ly Le As 400 Glu Glu Lys Lys Glu 480 Leu Gly Lys Glu Asn 560 Ile Phe Lys Gin Glu 640 Lys Ala Ala Asn Lys 720 Ala Ser Lys Asn L Asp 800 a Ser i Gin s Asn u Val n Phe 880 n Asn Lys Leu Gly Asn Phe As 890 89 Asn Asn Asn 900 Gly Leu Glu As Thr Glu Pro Ile Tyr Thr Gin 910 f. Incn OUCCT JIU4 S726Y09 12; 1396 392 Val Ala Lys Lys Val Lys Ala Lys Ile Asp Arg Leu Asp Gin Ile Ala 915 920 925 Ser Gly Leu Gly Asp Val Gly Gin Ala Ala Ser Phe Leu Leu Lys Arg 930 935 I 940 His Asp Lys Val Asp Asp Leu Ser Lys Val Gly Leu Ser Ala Asn His 945 950 955 960 Glu Pro-Ile Tyr Ala Thr Ile Asp Asp Leu Gly Gly Pro Phe Pro Leu 965 970 975 Lys Arg His Asp Lys Val Asp Asp Leu Ser Lys Val Gly Leu Ser Arg 980 985 990 Glu Gin Lys Leu Thr Gin Lys Ile Asp Asn Leu Asn Gln Ala Val Ser 995 1000 1005 Glu Ala Lys Ala Ser His Phe Asp Asn Leu Asp Gin Met Ile Asp Lys 1010 1015 1020 Leu Lys Asp Ser Thr Lys Lys Asn Val Val Asn Leu Tyr Val Glu Ser 1025 1030 1035 1040 Ala Lys Lys Val Pro Thr Ser Leu Ser Ala Lys Leu Asp Asn Tyr Ala 1045 1050 1055 Thr Asn Ser His Thr Arg Ile Asn Ser Asn Val Lys Asn Gly Thr Ile 1060 1065 1070 Asn Glu Lys Ala Thr Gly Met Leu Thr Gin Lys Asn Ser Glu Trp Leu 1075 1080 1085 Lys Leu Val Asn Asp Lys Ile Val Ala His Asn Val Gly Ser Ala Pro 1090 1095 1100 Leu Ser Ala Tyr Asp Lys Ile Gly Phe Asn Gln Lys Asn Met Lys Asp 1105 1110 1115 1120 Tyr Ser Asp Ser Phe Lys Phe Ser Thr Arg Leu Ser Asn Ala Val Lys 1125 1130 1135 Asp Ile Lys Ser Gly Phe Val Gin Phe Leu Thr Asn Ile Phe Ser Met 1140 1145 1150 Gly Ser Tyr Ser Leu Met Lys Ala Ser Val Glu His Gly Val Lys Asn 1155 1160 1165 Thr Asn Thr Lys Gly Gly Phe Gln Lys Ser 1170 1175 INFORMATION FOR SEQ ID NO:474: SEQUENCE CHARACTERISTICS: LENGTH: 162 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...162 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:474 Met Lys Ala Pro Ser Gin Unk Asp Leu Lys Lys Ile Leu Gly Ile Glu 1 5 10 Glu Val Ile Unk Unk Ser Thr Ser Pro Met Glu Leu Arg Leu Ala Asn 25 Gin Lys Leu Gly Asn Arg Phe Ile Lys Thr Leu Gin Ala Met Asn Glu 40 Leu Asp Met Gly Ala Phe Phe Asn Ala Tyr Ala Gln Thr Thr Lys Asp 55 \Pro Thr His Ala Thr Ser Tyr Gly Val Phe Ala Ala Ser Leu Asn Met A441aP3n9f-P ttfY! PCT/US 9 6 /09122 IPEA/US 10 OEC 199 Glu Met Gin Lys Asn 145 Met Leu Lys Lys Ala Val Ile Asn Cys 100 Lys Ile Leu Leu -115 Thr Leu Glu Leu 130 Asp Ile Lys Ala Ser 70 Leu Val Ser Asp Met 150 Arg His Tyr Leu 90 Lys Ser Val Pro 105 Leu Gin Ser Pro 120 Glu Ser His Leu 135 Gin His Glu Ser 75 Tyr Ala Gin Thr Ser Leu Ser Gln Asn Asp 110 Phe Asn Gin Leu Ile 125 Cys Ala Ala Ser Val 140 Leu Tyr Ser Arg Leu 155 Asn Gly Glu Gin Tyr 160 INFORMATION FOR SEQ ID NO:474: SEQUENCE
CHARACTERISTICS:
LENGTH: 162 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...162 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:474 Met Lys Ala Pro Ser Gin Unk Asp Leu Lys Lys 1 5 Glu Val Ile Unk Unk Ser Thr Ser Pro Met Glu I 25 Gin Lys Leu Gly Asn Arg Phe Ile Lys Thr Leu 40 Leu Asp Met Gly Ala Phe Phe Asn Ala Tyr Ala 55 Pro Thr His Ala Thr Ser Tyr Gly Val Phe Ala 70 75 Glu Leu Lys Lys Ala Leu Arg His Tyr Leu Tyr 90 Met Val Ile Asn Cys Val Lys Ser Val Pro Leu 100 105 Gin Lys Ile Leu Leu Ser Leu Gin Ser Pro Phe 115 120 Lys Thr Leu Glu Leu Asp Glu Ser His Leu Cys 130 135 Asn Asp Ile Lys Ala Met Gin His Glu Ser Leu 145 150 155 Met Ser INFORMATION FOR SEQ ID NO:47 5 SEQUENCE
CHARACTERISTICS:
LENGTH: 466 amino acids TYPE: amino acid TOPOLOGY: linear Ile Leu Gly Leu Arg Leu 3ln Ala Met 45 Gln Thr Thr Ala Ser Leu Ala Gin Thr Ser Gin Asn 110 Asn Gin Leu 125 Ala Ala Ser 140 Tyr Ser Arg Ile Glu 15 Ala Asn Asn Glu Lys Asp Asn Met Ser Asn Asp Gly Ile Glu Val Gin Leu Tyr 160 POrT/US 96/09122 394 (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION .466 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:475 1Met Lys Ala Leu Lys Thr Phe Leu Lys
I
Ala Pro Lys Gin Val Leu Ala Asn Cys 145 Lys Thr Ser Giu Gin 225 Thr Ile Gin Ph.
Asn 305 Arg Ile Lys Gin I le rhr rrp k.sp ksn Ser Lys r'yr 130 Pro As n Lys Thr Tyr 210 Leu Ala Ala Asp Gly 290 Arg Leu Ala His Asni 370 Ala Gin Ala Thr Asp Ile Gin 115 Asp Glu Leu Ala Ala 195 Ile Leu Tyr Ser Arg 275 Phe Asn Lys Gly Arg 355 Leu Leu PAsn Lys Leu Val1 Pro 100 Val1 Ile Leu His Leu 180 Asn Cys Asp Glu Asn 260 Ala Asn G ly Ala Lys 340 Phe Ser Asn Ala His Asp Leu2 Asn Gin2 Arg Asn Gin 165 Lys Asp Ile Ser Lys 245 Val1 Ph.
Asp Lys Gin 325 Lys Gin Phe iis Crp eu krg 70 ks n Pro kia ks n rrp 150 Phe Asp Leu Gin Gin 230 Leu Tyr Ser Giu Ser 310 Phe G ly Gin Met Lys Leu I Asn C Ala 55 Ala Lys I) Met C Asn Gin 135 Asp Phe Phe Gly Lys 215 Met Arg Ala Gin Asn 295 Giu Asp *Giu *Leu Asn 375 Gin ~sn ;ly 'hr s n ;ln rhr L20 Ile /a 1 rhr kia Ala 200 3iy Thr Ala Lys Met 280 Val Cys Ala Sex 360 Lyi Gir Ala 25 Ala Ile Gin Asn Tyr 10s Glu Ala Ser Sen Asn 185 Gly Asn Leu Giu Val 265 Asp Lys Ile Leu Ala 345 Val Thr SMet Ial .ys Thr L'hr ;ln la 1 krg Ala Gln Lys 170 Ala Leu Leu Ala Lys 250 Lys Asn Lys Pro Asfl 330 Ala Giu Leu Glj Sen Leu Ile L Ala Met Ile 3 Arg Ala Trp Glu Arg IleL Leu Asn Sen I 75 Ph. Leu Thr G Glu Lys Ile C Ile Lys Giu 125 Lys Arg Ile 140 Asp Ala Sen I 155 Gly Lys Giu Ile Gly Asn Arg Gly Arg2 205 Giu Ala AlaI 220 Leu Leu Asn 235 Glu Glu Leu Gin Leu Val Giu Leu Gly 285 Gly Tyr Cys 300 Asn Met Leu 315 Leu Asp Tyr Lys Val Ph.
Thr Ala Leu 365 Gly Leu Met 380 rTyr Ph. Glu 395 eu 'al 0 ,ys 1y ;in ~sn er 'ro ;er 190 Lys Val1 270 Val Lys Asr Se2 As: Gi: Va Asi Leu Asp Giu Leu Asn Se r Sen Ala Glu Thn Ala 175 Gin Leu Lys Asp Arg 255 Ala Lys Lys Va) Ar~ 33! 1x Asi u1 Ii 1 Ci: p Ii Leu Asn Sen Ala Lys Ile Phe Gin Lys Giu 160 Asn Ile Leu Ile Tyr 240 Gin Ser Thr Giu 320 1 Asp p Tyr e Ala ni Met e Ile 400 u Giu Ser Tyr Ala Ph.
390 Ala Asp Ala Leu Lys Asp Asp Lys Giu His Gin Giu Asn Le PCT/US 96/09122 395 405 410 415 Gin Lys Gin Gin Glu Ile.Glu Lys Val Tyr Arg Ala Lys Leu Asp Ala 420 425 430 Tyr Gly Phe Pro Asn Gly Ser Val Gly Lys Ala Ser Gly Val Asn Ser 435 440 445 Asn Ser Asn Asn Glu Ala Pro Ser Ser Asp Asn Ile Gin Ser Phe Asn 450 455 460 Pro Tyr 465 INFORMATION FOR SEQ ID NO:476: SEQUENCE CHARACTERISTICS: LENGTH: 59 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...59 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:476 Met Ala Phe Ile Leu Thr Thr Asn Leu Phe Ile Lys Ser Phe Thr Asn 1 5 10 Ser Ile Arg Ile Thr Gly Cys Ile Ile Ser Pro Asn Val Phe Phe Ala 25 Tyr Glu Phe Cys Ala Leu Gly Phe Arg Lys Gly Gly Leu Ile Leu Asp 40 Asn Phe Ser Lys Phe Val Ser His Arg Leu Gin INFORMATION FOR SEQ ID NO:476: SEQUENCE CHARACTERISTICS: LENGTH: 59 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...59 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:476 Met Ala Phe Ile Leu Thr Thr Asn Leu Phe Ile Lys Ser Phe Thr Asn 1 5 10 Ser Ile Arg Ile Thr Gly Cys Ile Ile Ser Pro Asn Val Phe Phe Ala 25 -O o Cr/iS 96/09122 IPENUJS 18 0EC 1996 396 Tyr Glu Phe Cys Ala Leu Gly Phe Arg Lys Gly Gly Leu lie Leu Asp 40 Asn Phe Ser Lys Phe Val Ser His Arg Leu Gin INFORMATION FOR SEQ ID NO:477: SEQUENCE CHARACTERISTICS: LENGTH: 248 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...248 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:477 Val Ara Phe Phe Ile Phe Leu Ile Leu Ile Cys Pro Leu Ile Cys Pro 1 Leu Met I Ala Pro S Leu Leu Ser Phe Gly Thr Ile Leu Thr Gly Phe Glu 130 Arg Glu 145 Pro Lys Met Ile Leu Pro Met Gly 210 Ile Leu 225 Leu Val Ser I Ser rhr rhr Gln Thr Ile 115 Lys Lys Thr Ser Phe 195 Met Val Ala Ala Asp Leu Arg G1n Phe 100 Lys Ser Asp Pro Glu 180 Leu Met Phe Ser 5 Asp S Pro I Leu Leu Thr Phe Pro Thr Leu Asp 165 Leu Val Met Ile Phe 245 er Lys Val Ile 70 Pro Ile Tyr Leu Ala 150 Asp Lys Ile Let Let 23 Lys Ala Leu Gin Leu 40 Leu Ala 55 Val Val Pro Thr Met Glu Met Asp 120 Pro Phe 135 Leu Phe Val Ser Thr Ala Asp Met Pro 25 /al Pro Phe Gin Pro 105 Lys Lys Phe Leu Phe 185 Val Ser Thr Ser Ser Ile 90 Ser Lys Glu Arg Ser 170 SGin SIle Val Thr Leu Phe 75 Leu Leu Ile Phe Ile 155 Val Ile Ser Ile Asn 235 Asn Leu Ile Leu Val Lys Ser Met 140 Arg Leu Gly Ser Leu Asn Leu Arg Ser Lys Tyr 125 Leu Asn Ile Phe Ile Ser Val Val Thr Leu Ala 110 Thr Lys Leou Pro Leu 190 Leu Leu Ile Met Ala Ser Tyr Glu Asn Pro Ala 175 Leu Met Asn Ala Thr Leu Leu Asp Ala Thr Asn 160 Phe Tyr Ala 0 s Pro 215 Val Met 200 Pro Asp Val Val Met Gly Phe 205 Ser Leu Pro Phe Lys 220 Leu Leu Thr Glu Asn 240 INFORMATION FOR SEQ ID NO:477: SEQUENCE CHARACTERISTICS: LENGTH: 248 amino acids TYPE: amino acid POT/US 96/O9122 1P7- 397 TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) -ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .248 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:477 Val1 1 Leu Ala Leu Ser Gly Ile Thr Phe Arg 145 Pro Met Leu Met Ile 225 Leu Arg Met Pro Leu Phe Thr Leu dly Glu 130 Glu Lys Ilie Pro Gly 210 Leu Val1 Phe Phe Ile Phe Leu Ilie Leu Ile Cys Ser Ser Thr Thr Gin Thr Ile 115 Lys Lys Thr Ser Phe 195 Met Val1 Ala Ala Asp Leu Arg Gin Phe 100 Lys Ser Asp Pro Glu 180 Leu Met Phe Ser 5 Asp Pro Leu Leu Thr Phe Pro Thr Leu Asp 165 Leu Val1 Met Ile Phe 245 Ser Lys Val1 Ile 70 Pro Ile Tyr Leu Ala 150 Asp Lys I le Leu Leu 230 Lys Ala Gin Leu 55 Val1 Pro Met Met Pro 135 Leu Val1 Thr Asp Pro 215 Val1 Met Leu Leu 40 Ala Val1 Thr Glu Asp 120 Phe Phe Ser Ala Met 200 Pro Asp Val Pro 25 Val1 Pro Phe Gin Pro 105 Lys Lys Phe Leu Phe 185 Val Val1 G ly 10 Ser Thr Ser Ser Ile 90 Se r Lys Glu Arg Ser 170 Gin Ile Met Val1 Thr Leu Phe 75 Leu Leu Ile Phe Ile 155 Val1 Ile Ser Ile Pro Asn Leu Ile Leu Val1 Lys Ser Met 140 Arg Leu Giy Se r Ser 220 Leu Leu Asn Leu Arg Se r Lys Tyr 125 Leu As n Ile Phe Ile 205 Leu Ile Ser Val1 Val1 Thr Leu Ala 110 Thr Lys Leu Pro Leu 190 Leu Pro Cys Leu Ile Met Ala Ser Tyr Giu As n Pro Ala 175 Leu Met Phe Pro As n Ala Thr Leu Leu Asp Ala Thr Asn 160 Phe Tyr Ala Lys Phe Asn Leu Leu Thr Glu Asn 235 240 INFORMATION FOR SEQ ID NO:478: Ci) SEQUENCE CHARACTERISTICS: LENGTH: 44 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: (NAME/KEY: miscfeature PCTI/US 9 6 /0 912 2 IPtPNU0 1.0LJC 1996 398 LOCATION .44 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:478 Val Met Asp Ala Glu Asn Gly Giu Leu Leu Val Ala Gly Ser Tyr Pro 1 5 10 Giu Tyr Asn Leu Asn Asp Phe Val Gly Gly Ile Ser Gin Asp Lys Trp 25 Gin Lys Leu Gin Asp Asp Ilie Tyr Asn Pro Leu-Leu INFORMATION FOR SEQ ID NO:479: SEQUENCE
CHARACTERISTICS:
LENGTH: 421 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc-feature LOCATION I1.. .421 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:479 Met Asn Phe Phe Asp Thr Leu Met Gly Met Phe Val Giu Pro Sen Gin 1 5 10 Lys.Val Ala Lys Ser Leu Ala Giu His Val Gly Ser Phe Phe His Ala 25 Gin Leu Ilie Leu Asn Thr Ile Ile Thr Ile Leu Phe Met Ile Trp Ala 40 Tyr Lys Arg Val Lys Glu Gly Asp Met Phe Giu Ph. Lys Thn Ala Met 55 Gly Val Val Vai Phe Ile Ala Phe Val Gly Phe Ile Asn Trp Gly Ile 70 75 Lys Asn Pro Asn Asp Phe Asn Thr Tyr Phe Ile Asn Thr Ile Ph. Tyr 90 Pro Ser Glu Lys Leu Ala Ile Leu Ile Ala Gin Sen Leu Asn Asp Gly 100 10S 110 Leu Giu Ile Pro Thr Asn Thr Asn Leu 5cr Pro Ser Glu Ile Ph. Ser 115 120 125 Ile Gly Asn Leu Ala Ser Ser Ala Tyr Ala Met Ile Val Asn Leu Trp 130 135 140 Asp Asn Ala Phe Asp Gly Ile Asn Met Phe Asn Trp, Leu Thr Met Ile 145 150 155 160 Pro Lys Ilie Ile Met Phe Ph. Leu Val Ile Leu Gly Glu Leu Leu Ph.
165 170 175 Leu Gly Leu Leu Leu Ile Ile Val Leu Leu Val Thr Ala Giu Ile Phe 180 185 190 Met Trp Sen Ala Leu Gly Leu Ile Val Leu Pro Leu Gly Leu Ile Pro 195 200 205 Gin Thn Lys Gly Met Leu Phe Ser Tyr Leu Lys Lys Leu Ile Sen Leu 210 215 220 Thr Leu Tyr Lys Pro Cys Met Met Leu Vai Ala Ph. Phe Asn Tyr Gly 225 230 235 240 Ie Ile Tyr Lys Val Asn Thr Leu Ile Pro Thn Lys His Glu Val Thr \i245 250 255 k ln Gly Ph. Tyr Gly Asn Ala Asp Lys Met Ala Asn -lu Gly Lys Ile -A 4 _q I I 11 I- "N f I I- P"q- POT/US 96/G91 IPENS 1 b DEC 1996 Ile Ala Val1 305 Ile Lys Met Leu Ser 385 Val1 Asp Asp His 290 Ile Phe Ile Val1 Ala 370 Gly Lys Lys Val1 275 Ser Cys Gly G iy Ala 355 Gly Gly His As n 260 Phe Ser Phe Thr Met 340 Asn Leu Ala Ph.
As n 420 Gly Ile Phe Ser 325 Thr Gin Gin Ser Val1 405 Lys Val1 Giy 295 Val1 Gly Gly Lys Gly 375 Met Ser 265 Glu Leu Arg G ly Ala 345 Ala Lys As n Lys G iy Thr Val1 Ala 330 Val1 Tyr Ala His Ser 410 Asp Ile Pro 315 Val1 Phe Gin Phe Arg 395 Gly Trp Ile 300 Asp Thr Gly Ser Gly 380 Ser Phe INFORMATION FOR SEQ ID NO:480: SEQUENCE CHARACTERISTICS: LENGTH: 166 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .166 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:480 Leu Leu Val Thr Phe Leu Asn Gly Phe Asp Pro Lys Ile Ala 1 Arg Thr Lys Phe Ser Lys Ile Giu G iu 14 5 Lys Asn Arg s0 Ser G ly Lys Asp Pro 130 Lys Arg Ala Thr GiU Arg Ser Giu Ala 115 Lys Unk Ser Cys Leu Leu Val1 Gin Lys 100 Arg Lys Tyr Phe 5s Asn Asp G lu Ser Arg Glu Ala Gin Lys 165 Val1 Ile Thr Gly 70 Lys Lys Asn Asn Lys 150 Unk Tyr Ser Leu Sen 40 Ser Gly 55 Ile Asp Asn Tyr Giu Val Lys Ang 120 Gin Gly 135 Ala Glu Val1 25 Cys Val.
Ala Phe Arg 105 Glu Thr Arg 10 G ly G lu Thr Gly Ala 90 Ile Ile Giu Lys Val1 Ser Lys Thr 75 Tyr G lu Lys Asn Phe 155 Ile Phe Thr Leu Tyr Lys Gin Ala 140 Asp Tyr Giu 4S Ser Gly Asp Lys G lu 125 Pro Ala Ile Ile Thr Lys Ala Glu 110 Ala Thr Lys Asn Val Leu Pro Leu Leu Giu Ile Leu Unk I'hr Glu Ph.
Ph.
Val1 Arg Lys G lu Unk 160 PCT/US 96/09122 IPEA/US 18 DEC 1996 400 INFORMATION FOR SEQ ID NO:480: SEQUENCE CHARACTERISTICS: LENGTH: 166 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...166 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:480 Leu Leu Val Thr Phe Leu Asn Gly Phe Asp Pro Lys Ile Ala Asn Leu 1 5 10 Arg Lys Ala Cys Asn Val Tyr Ser Val Gly Val Ile Tyr Ile Val Thr 25 Thr Asn Thr Leu Asn Ile Leu Ser Cys Glu Ser Phe Giu Ile Leu Glu 40 Lys Arg Glu Leu Asp Thr Ser Gly Val Thr Lys Thr Ser Thr Pro Phe 55 Phe Ser Arg Val Giu Gly Ile Asp Ala Gly Thr Leu Gly Lys Leu Phe 70 75 Ser Gly Ser Gln Ser Lys Asn Tyr Phe Ala Tyr Tyr Asp Ala Leu Val 90 Lys Lys Glu Lys Arg Lys Glu Val Arg Ile Glu Lys Lys Glu Glu Arg 100 105 110 Ile Asp Ala Arg Glu Asn Lys Arg Glu Ile Lys Gln Glu Ala Ile Lys 115 120 125 Glu Pro Lys Lys Ala Asn Gln Gly Thr Glu Asn Ala Pro Thr Leu Glu 130 135 140 Glu Lys Unk Tyr Gln Lys Ala Glu Arg Lys Phe Asp Ala Lys Unk Unk 145 150 155 160 Arg Arg Ser Phe Lys Unk 165 INFORMATION FOR SEQ ID NO:481: SEQUENCE CHARACTERISTICS: LENGTH: 89 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .89 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:481 1PEUS b DEC 1996 Met Ser Ala Leu Lys Asp Asp Giu Asn Leu Thr His Lys Asn Ser Val Leu Leu Pro Ile Asp Gly Ala Ala Giu Ser Pro Asri Lys Leu Lou Asn Leu 40 Gin Asn Asp Glu Thr 25 Asp Ph.
Ile Gin Asn 10 Gin Gin Ser Cys Lys Pro Lys Giu 75 Ala Leu Ile Leu Thr Ser Giu Trp Val Leu Asn Ser Lys Pro Thr Arg Ile Leu Ile Thr Leu Ile Lou Leu Lys INFORMATION FOR SEQ ID NO:482: SEQUENCE CHARACTERISTICS: LENGTH: 237 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .237 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:482 1Val Lys Thr Leu Gly Lou Sen Ser Leu Gly Gly Thn Lou Glu Ph. Tyr Asp Phe Ile Ala Ile Ph.
Lys Val Trp 145 Ile Lou Asp Ile Ph. Ile Pro Asn Phe Ala His Ph.
Leu Lou Asn Asp Asn Ala, .115 Arg Ile 130 Val Phe Gly Ph.
Val Tyr Trp Ala 195 Sen Val 210 Ile Thr Ala Gly Met Lou 100 His Cys Val Leu Ile 180 Tnp Tyr Phe Leu Gly Asp Val Val Gin His Thr 165 Gly Ang Lou Val Ph.
Ser Pro Tyr Lou 55 Lys Ph.
70 Ile Pro Gly Ph.
Lou Gly Gly Val 135 Giu His 150 Ala Sen Ile Tyr Val Ala Ang Arg 215 Ph.
Ile 40 Ala Gly Thr Giy Tyr 120 Ala Ala Val1 Met Ph.
200 Ph.
Thr 25 Trp Ang Ang Phe Val 105 Ile Val Pro Val1 Val1 185 Gly Lou 10r Ser Pro Lys Ala 90 Asp Ala Gly Gin Ser 170 Ph.
Lou Glu Ile Glu Lou Asn 75 Lou Son Pro Gly Gly 155 Gly Asp Gly Glu Ile Ile Gly Met Ala Met Val1 Giu 140 Gin Ile Lys Gly Thn 220 Ala Asn Gly Ph.
Lou Gly Ph.
125 Lou Lys Lou Pro Ile 205 Pro Lys Thr Ile Met Met Leu 110 Lou Pro Asn Lou Val 190 Ph.
Val1 is Tyr Val1 Lou Pro Thr Val1 Gly Thr Gly 175 Val Gly Ph.
Ph.
Gly Met Ser Thr Pro Lou Ala Tyr 160 Ser Glu Ile Gin Met Lys Gin Gly Ang Cys Lou Sen Gin 230 Ile Pro Ala 235 &Iqk~ri q1WFF EDITORIAL NOTE NUMBER 63278/96 THIS SPECIFICATION DOES NOT CONTAIN PAGES NUMBERED: 402;404;406;408;410;412;414;416;418; 420;422;424;426;428.
IPEAMS 18 DEC 1996 403 340 345 350 Leu Tyr Ser'Asn Phe Glu His Cys Arg His Leu Ala Leu Lys Cys Leu 355 360 365 Asp Asn Tyr Arg Lys Tyr Leu Phe Ser Ser Asn Leu Glu Gly Asn Ile 370 375 380 Ala Ile Val Asp Thr Ile Thr Leu Gly Tyr Ser Ser Gln Gly Leu Ile 385 390 395 400 Gin Lys Ala Leu Asn Lys Glu Val Phe Gly Cys Tyr Val Asp Leu Leu 405 410 415 Arg Ile Leu Asn Tyr Asp Cys Val Ser Phe Leu Pro Phe Ser His Pro 420 425 430 Lys Pro Val Tyr Phe His Asn Trp Asp Phe Met Glu Phe Leu Leu Thr 435 440 445 Ser Pro Glu Tyr Pro lie Leu Asn Val Glu Asn Gly Val Pro Ile Leu 450 455 460 Ser Lys Arg Arg Phe Ile Leu 465 470 INFORMATION FOR SEQ ID NO:484: SEQUENCE CHARACTERISTICS: LENGTH: 123 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...123 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:484 Val Leu Lys Phe Phe Glu Asp Ser Lys Gln Leu Ser Thr Pro Met Gly 1 5 10 Lys Ser Ala Val Gly Ile Leu Ile Phe Gln Asp Ile Ala Ala Ile Pro 25 Met Leu Leu Ile Leu Thr Ile Leu Gly Ser Lys Asp Ser His Val Asn 40 Leu Leu Ile Leu Lys Thr Leu Ile Ser Ala Gly Ile Ile Leu Ile Leu 55 Leu Leu Leu Pro Gly Lys Lys Gly Ala Asn Leu Ile Leu Glu Gln Ala 70 75 Lys Asp Thr Arg Leu Pro Glu Ile Phe Ile Gly Thr Asp Phe Ser Asp 90 Cys Leu Gln Arg Gly Gly Val Glu Pro Phe Phe Trp Val Phe Tyr Val 100 105 110 Phe Gly Gly Val His Cys Gly His Gly Asp Phe 115 120 INFORMATION FOR SEQ ID NO:485: SEQUENCE CHARACTERISTICS: LENGTH: 127 amino acids TYPE: amino acid TOPOLOGY: linear S(ii) MOLECULE TYPE: protein 0,1 orv"Irr% ks, PPIT/I 9 6/ 09 12 ipaAS 18 DEC 1996 INFORMATION FOR SEQ ID NO:486: SEQUENCE CHARACTERISTICS: LENGTH: 259 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .259 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:486 Met Ile Leu Ala Leu Leu Ile Ser Lys Giu Lys Thr His Leu 1 Leu Leu Phe Tyr Phe Leu Leu Ile As n 145 Phe Ser Lys Leu Lys 225 Tyr Leu Lys Arg Phe Asp Tyr Ala 130 Asn Leu Lys Asp Leu 210 Leu Tyr His Gly Leu Pro Thr Tyr 115 Ile Gin Val Giu Thr 195 Pro Giu Leu Phe Leu As n Ser Thr 100 Ala Ser Gin Gly Ile 180 Leu Phe Gin 5 Ser Tyr Leu Arg Val1 Ile Asn Thr Asp Val 165 Thr Ile Giy Lys Tyr Pro Gly Ala 70 Leu Ala Arg Ala Leu 150 Leu Giu Thr Leu Lys 230 Gly Leu Phe 55 Lys Gly Ser Val1 Leu 135 Ile Leu Leu Sen Thr 215 Ala Val1 Val1 40 Lys Lys Asn Phe Phe 120 Phe Leu Leu Leu Gin 200 Lys Ala Leu 25 Lys Thr Asp Ser Leu 105 Gin Pro Gin Cys Phe 185 Val Leu Lys Leu Leu Lys Leu Ser 90 Ala Leu Ser Arg Ser 170 Giu Phe Phe I le Met 250 Gly Gly Asn Lys 75 Ala Ser Pro Ile Leu 155 Ile Arg Ser Ser Sen 235 Gly Leu Thr Ala Gin Gly Leu Ala 140 Gln Gly Gly Leu Leu 220 Leu Val l'rp Asn Phe Ile Ser Ala 125 Ile Lys Gly Gin Tyr 205 Trp Ile Ala Asp Lys Phe Ala Val1 110 Leu Ala Ala Ile Phe 190 Leu Leu Ser Giu Gin Leu Lys Lys Ser Ser Phe Leu Trp Met 175 Ser Leu Tyr Leu Val 255 A~la Ile Leu Giu Gin Phe Tyr Ala Lys Phe 160 Leu Pro Gly Ala Phe 240 Leu Leu Gly Leu Ala Ala 245 Gly Leu Arg Ser Leu Ser Leu Pro Leu Leu Gly INFORMATION FOR SEQ ID NO:487: SEQUENCE CHARACTERISTICS: LENGTH: 16 amino acids TYPE: amino acid TOPOLOGY: linear a. .,~iv~IM 96/09 12 2 IPEAUS 18 DEC 1996 407 25 Lys Glu Asp-Met Gin Lys Leu Lys Pro Glu Ala Pro Ile Phe Leu Met 40 Ser Ser Lys Asp Pro Lys Ser Leu Glu Asp Phe Lys Asn Phe Leu Leu 55 Glu Lys Lys Arg Glu Asn Tyr Gln Ser Thr His Ser Phe 70 INFORMATION FOR SEQ ID NO:489: SEQUENCE CHARACTERISTICS: LENGTH: 180 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...180 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:489 Met Leu Leu Cys Ala Gly Arg Asn Glu Thr Leu Lys Lys Ala Val Pro 1 5 10 Ile Gly Val Gly Leu Ile Glu Ser Ala Ile Asn Leu Thr Arg Met Cys 25 Leu Lys Asn Pro Asp Thr Glu Ser Leu Ile Phe Ile Gly Ser Ala Gly 40 Ser Tyr Ser Pro Glu Thr Glu Ile Leu Ser Val Phe Glu Ser Ile Glu 55 Gly Tyr Gln Ile Glu Glu Ser Phe Ser His Leu Asn Ser Tyr Thr Pro 70 75 Leu Asp Asn Phe Ile His Ile Glu Thr Lys Glu Gin Ala Leu Phe Glu 90 Arg Val Arg Val Asn Ser Ser Asn Tyr Ile His Thr Ser Glu Met Phe 100 105 110 Ala Lys Lys Met Val Gin Lys Gly Val Leu Leu Glu Asn Met Glu Phe .115 120 125 Phe Ser Val Leu Ser Val Ala Lys Ile Phe Ser Leu Lys Ala Lys Gly 130 135 140 Ile Phe Cys Val Ser Asn His Val Gly Leu Asn Ala His Lys Glu Phe 145 150 155 160 Lys Glu Asn His Ala Lys Val Lys Gln Ile Leu Glu Asn Ile Ile Asp 165. 170 175 Ser Leu Ile Val 180 INFORMATION FOR SEQ ID NO:490: SEQUENCE CHARACTERISTICS: LENGTH: 213 amino acids TYPE: amino acid TOPOLOGY: linear S(ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES f\-tt* 7 409o IPEA/US 18 DEC 1996 40 Tyr Lys Leu His Lys Asn His Gly Ser Glu Thr Glu Thr Lys Asn Asp 55 Lys Lys Leu Tyr Asp Phe Thr Lys Asn Ser Gly Leu Glu Gly Val Asp 70 75 Leu Glu Lys Ser Pro Asn Leu Lys Ser His Lys Lys Ser Asp Lys Lys 90 Phe Tyr Lys Gln Leu Ala Lys Asn Asn Ile Ala Glu Gly Val Ser Met 100 105 110 Pro Ile Val Asn Phe Asn Lys Ala Leu Ser Phe Gly Pro Tyr Phe Glu 115 120 125 Arg Thr Lys Ser Lys Lys Thr Gln Tyr Met Asp Gly Gly Leu Met Met 130 135 140 His Ile Arg Phe 145 INFORMATION FOR SEQ ID NO:492: SEQUENCE CHARACTERISTICS: LENGTH: 281 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...281 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:492 Val Met Ile Asp Pro Lys Met Val Glu Phe Ser Ile Tyr Ala Asp Ile 1 5 10 Pro His Leu Leu Thr Pro Ile Ile Thr Asp Pro Lys Lys Ala Ile Gly 25 Ala Leu Gln Ser Val Ala Lys Glu Met Glu Arg Arg Tyr Ser Leu Met 40 Ser Glu Tyr Lys Val Lys Thr Ile Asp Ser Tyr Asn Glu Gln Ala Gin 55 Ser Asn Asp Val Glu Ala Phe Pro Tyr Leu Ile Val Val Ile Asp Glu 70 75 Leu Ala Asp Leu Met Met Thr Gly Gly Lys Glu Ala Glu Phe Pro Ile 90 Ala Arg Ile Ala Gln Met Gly Arg Ala Ser Gly Leu His Leu Ile Val 100 105 110 Ala Thr Gln Arg Pro Ser Val Asp Val Val Thr Gly Leu Ile Lys Thr 115 120 125 Asn Leu Pro Ser Arg Val Ser Phe Arg Val Gly Thr Lys Ile Asp Ser 130 135 140 Lys Val Ile Leu Asp Thr Asp Gly Ala Gln Ser Leu Leu Gly Arg Gly 145 150 155 160 Asp Met Leu Phe Thr Pro Pro Gly Thr Asn Gly Leu Val Arg Leu His 165 170 175 Ala Pro Phe Ala Thr Glu Asp Glu Ile Lys Lys Ile Val Asp Phe Ile 180 185 190 Lys Ala Gln Lys Glu Val Glu Tyr Asp Lys Asp Phe Leu Leu Glu Glu 195 200 205 Ser Arg Met Pro Leu Asp Thr Pro Asn Tyr Gln Gly Asp Asp Ile Leu 210 215 220 PCT/US 9 6 0 9 12 2.
IPENUS 60 EC 1996 411 NAME/KEY: misc_feature LOCATION 1...73 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:494 Val Gly Gly Leu Ala Met Leu Gly Phe Phe Tyr Asn Ile Glu Lys Ile 1 5 10 Ser Leu Ala Thr Ala Thr Ala Phe Ser Gln Cys Ala Pro Unk Tyr Thr 25 Val Leu Leu Ser Pro Leu Leu Leu Lys Glu Lys Leu Lys Arg Ser Ala 40 Leu Ile Ser Ala Cys Ile Gly Leu Val Gly Val Val Leu Ile Ser Asp 55 Pro Ser Val Glu Asn Val Gly Pro Ser INFORMATION FOR SEQ ID NO:495: SEQUENCE CHARACTERISTICS: LENGTH: 311 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...311 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:495 Val Cys Trp Thr Asp Leu Ile Gln Gly Leu Leu Met Met Ser Ala Leu 1 5 10 Ile Val Val Pro Ile Val Met Ile Ile His Leu Gly Gly Ile Gly Glu 25 Gly Ile Lys Ile Ile Arg Glu Ile Lys Pro Glu Asn Leu Ser Phe Unk 40 Gin Gly Ser Ser Val Val Ala Ile Ile Ser Ser Leu Ala Trp Gly Leu 55 Gly Tyr Phe Gly Gln Pro His Ile Leu Val Arg Phe Met Ser Ile Arg 70 75 Ser Ile Arg Asp Val Pro Lys Ala Thr Thr Ile Gly Ile Ser Trp Met 90 Val Ile Ser Leu Ile Gly Ala Cys Val Met Gly Leu Leu Gly Val Ala 100 105 110 Tyr Val His Lys Unk Asp Leu Ser Leu Glu Asp Pro Glu Lys Ile Phe 115 120 125 Ile Val Met Ser Gin Leu Leu Phe Asn Pro Trp Ile Thr Gly Ile Leu 130 135 140 Leu Ser Ala Ile Leu Ala Ala Val Met Ser Thr Ala Ser Ser Gln Leu 145 150 155 160 Leu Val Ser Ser Ser Thr Ile Ala Glu Asp Phe Tyr Ala Thr Ile Phe 165 170 175 Asn Lys Asn Ala Pro Gln Lys Leu Val Met Thr Ile Ser Arg Leu Ser 180 185 190 Val Leu Gly Val Ala Cys Ile Ala Phe Phe Ile Ser Thr Asp Lys Asn 195 200 205 Ala Ser Ile Leu Ser Ile Val Ser Tyr Ala Trp Ala Gly Phe Gly Ala 210 215 220 Ijv e C IPEA/US 18 DEC 1996 413 (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...200 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:497 Met Leu Val Gly Pro Thr Gly Val Gly Lys Thr Thr Thr Leu Ala Lys 1 5 10 Leu Ala Ala Arg Tyr Ser Arg Met Leu Ala Lys Lys Tyr Lys Val Gly 25 Ile Ile Thr Leu Asp Asn Tyr Arg Ile Gly Ala Leu Glu Gln Leu Ser 40 Trp Tyr Ala Asn Lys Met Lys Met Ser Ile Glu Ala Val Ile Asp Ala 55 Lys Asp Phe Ala Lys Glu Ile Glu Ala Leu Glu Tyr Cys Asp Phe Ile 70 75 Leu Val Asp Thr Thr Gly His Ser Gln Tyr Asp Lys Glu Lys Ile Ala 90 Gly Leu Lys Glu Phe Ile Asp Gly Gly Tyr Asn Ile Asp Val Ser Leu 100 105 110 Val Leu Ser Val Thr Thr Lys Tyr Glu Asp Met Lys Asp Ile Tyr Asp 115 120 125 Ser Phe Gly Val Leu Gly Ile Asp Thr Leu Ile Phe Thr Lys Leu Asp 130 35 140 Glu Ser Arg Gly Leu Gly Asn Leu Phe Ser Leu Val His Glu Ser Gin 145 150 155 160 Lys Pro Ile Ser Tyr Leu Ser Val Gly Gln Glu Val Pro Met Asp Leu 165 170 175 Lys Val Ala Thr Asn Glu Tyr Leu Val Asp Cys Met Leu Asp Gly Phe 180 185 190 Ser Asn Pro Asn Lys Giu Gln Ala 195 200 INFORMATION FOR SEQ ID NO:498: SEQUENCE CHARACTERISTICS: LENGTH: 264 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii). HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...264 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:498 Val Gly Gly Ala Ser Phe lie Ser Gly Gly Asn Gly Thr Leu Tyr Gly 1 5 10 Leu Asn Val Gly Tyr Asp Arg Leu Val Lys Ser Val Ile Leu Gly Gly 25 Tyr Val Ala Tyr Gly Tyr Ser Gly Phe Asn Gly Asn Ile Met His Ser 40 Leu Ala Asn Asn Val Asp Val Gly Met Tyr Ala Arg Ala Phe Leu Lys 55 Arg Asn Glu Phe Thr Leu Ser Ala Asn Glu Thr Tyr Gly Gly Asn Ala 70 75 Ak~FmmnF Qu~can POT/US 96/0912 IPENJUS 18 DEC 1996 145 Thr Ile Ser Ala Thr 225 Pro Giu Gin Leu Giu 305 Ile Phe His Leu Val1 Leu 210 Leu Leu Arg Ile Gly 290 Ser Asp G iu Phe Giu Gly Phe Ala Ser Leu Asn 275 Asn Gly Giu Asn Leu Leu 180 Asp Tyr Gin Cys Ser 260 Ala Tyr Ala Gly 150 Gly Vai 165 Gin Gly Lys Asp Tyr Giu Leu Asn 230 Leu Leu 245 Leu Asn Pro Leu Ser Asn Ile Gin 310 155 Leu Lys Asp Asp Lys Tyr Phe Lys 215 Gin Val1 Lys Lys His 295 Ala Asp Phe 200 Val1 Ser Leu Asp Leu 280 Gin Leu Val1 185 Lys Asn Ile Arg Phe 265 Asn Phe Ala Ile Leu Asp Aia Leu Lys Ile Ile 235 Val Leu 250 Lys Leu Asn Lys Ile Pro Gin Vai 315 Asn Ser Leu Pro 220 Gly Ile Lys Arg Tyr 300 Asp Leu Ser Lys 205 Giy Leu Leu Pro Thr 285 Asn Ser Gin Ala 190 Giu Lys Pro Pro Phe 270 His Asn Ile Leu 175 Giy Arg Pro Gly Leu 255 Lys Leu Arg Thr Lys Vali Asn Vali Asn 240 Leu Ala Ile Tyr Leu 320 Val Giy Leu Val Gin 325 Gly 330 Giu Ile Giu Ile 335 INFORMATION FOR SEQ ID NO:500: SEQUENCE
CHARACTERISTICS:
LENGTH: 146 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori.
(ix) FEATURE: NAME/KEY: misc-feature LOCATION 1 146 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:500 Met Pro Tyr Aia Leu Arg Lys Arg Phe Phe Lys 1 5 10 Phe Leu Ile Val Cys Met Ile Asn Leu His Aia 25 Ser Pro Leu Pro Pro Ala His Gin Gin Ile Ile 40 Ser Leu Giu Cys Leu Lys Asp Leu Met Leu Gin 55 Phe Vai Ser Gin Tyr Asp Asp Asn Asn Gin Asp 70 75 Tyr Tyr Lys Asp Ile Leu Asn Lys Leu Asn Pro 90 Gin Thr Pro Ala Lys Giu Ser Tyr Glu Pro Lys 100 105 Leu Leu Pro Lys Lys Val Val Gly Arg Tyr Ala 115 120 \Thr Leu Leu Ala Tyr Phe Giu His Gin Lys Gin INX 130 135 Arg Lys Lys Asn 60 G iu Val1 Ile Ile ArS 140 Leu Leu Leu is Ser Tyr Leu Thr Giu Pro Gin Ile Phe Ser Leu Lys Phe Ile Ala Giu Leu Ala 110 Leu Val Met 125 Phe Gin Tyr he Phe CyS Ser Thr Ser Ile Asn Pro a. IpEA(US i 63 DEC'W6 Lys Met Phe Giu Sr Tyr Gly Val Asn Pro Phe Arg Ile Leu 145 Gin Lys Gin Asp Leu 225 Phe Giu Vali Leu Lys 305 Gly Ile Pro Asn 115 Asp Gly 130 Lys Asn Lys His Leu Ser Gly Aia 195 Ser Asp 210 Phe Lys Ala Trp Arg Vai Ile Unk 275 Val Thr 290 Asp Leu Ser Val Phe Ilie 100 Ile Ile Asn Gin Asp 180 Gin Glu Leu Ile Tyr 260 Unk Val1 Phe His G ly 340 Pro Ser Gin Leu 165 G1u Asn Ala Val1 Leu 245 Thr Ile Leu Met Val1 325 Asp Asn Phe Thr 150 Leu Ile Ile Ile Tyr 230 Lys Val1 Unk Gly Ser 310 G ly Val1 135 Ser Asn Tyr Leu Ser 215 Val1 Ile Asn Leu Phe 295 Leu Asp Leu Pro 120 Leu Lys 200 Ile Phe Ile Lys Phe 280 Ala Leu Arg Asp 105 Asn Ile Ser Met Gly Giu Trp His 170 Thr Gin 185 Thr Thr Val Lys Leu Ala Ser Ser 250 Ala Ile 265 Ser Tyr Ser Ala Gly Trp Val Arg 330 Thr Ser 345 Ala Arg Val1 155 Ala Ala Ile Ser Ala 235 Lys Asn Leu Gly Phe 315 Ile Asr Lys Asn Leu 140 Leu Leu Lys Gly Gin 220 Leu Tyr Phe Glu Leu 300 Ile Ala Val A~sp Pro 125 Lys Asp Arg Ile 205 Val1 Leu Ile Val1 Asn 285 Ala Ile Lys Val Leu 110 Ile His Leu Lys Leu 190 Phe Lys Ser Giu Asn 270 Val1 Sle *Leu c Gi -His Ile Giu Ala Ile Glu Asn Leu Asp 160 Ser Ala 175 Giu Leu Gin Lys Asn Gin Val Val 240 Asn Asn 255 Val Ser Thr Tyr Unk Met Ile Gly 320 Thr Asp 335 INFORMATION FOR SEQ ID NO:502: SEQUENCE CHARACTERISTICS: LENGTH: 350 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii). HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .350 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:502 Met Ala Leu Arg Val Leu Leu Phe Phe Cys Phe Leu Phe Leu Gin Ala 1 5 10 Giu Asp Lys Sen Gin Giu Leu Sen Ser Ile Gin Lys Gin Met Ala Leu 25 Val Asp Lys Lys Leu Ala Lys Asp Asp Asn Val Trp Leu Lys Lys Phe 40 Giu Asn Tyr Lys Ile Tyr Asn Gin Ile Tyr Thr Giu Lys Giu Sen Val 55 Arg Gin Giu Leu Ang Arg Leu Lys Asn Lys Lys Ser Lys Asp Leu Leu 6570 75 AuFmnfln owFFm PCT/US 96/09122 IPENUS 18 DEC 133 419 70 75 Val Ser Gly Ala Val Phe Met Met Phe Ala His Gly Val Ile Val Met 90 Gly Leu Phe Leu Leu Ala Gly Ile Leu Glu Glu Arg Ala Ser Ser Leu 100 105 110 Glu Ile Ala Arg Phe Gly Ser Ile Ala Lys Ser Ala Pro Val Phe Ala 115 120 125 Ala Phe Phe Met Ile Val Leu Met Ala Asn Val Gly Met Pro Leu Ser 130 135 140 Ile Gly Phe Val Gly Glu Phe Leu Asn Leu Leu Gly Phe Phe Ala Thr 145 150 155 160 Tyr Pro Leu Leu Ala Ile Ile Ala Gly Thr Ser Leu Ile Leu Ser Ala 165 170 175 Val Tyr lie Leu Thr Ser Tyr Lys Asp Val Phe Phe Gly Asn Leu Lys 180 185 190 Thr Gly Asn Asn Gln Ile Ser Val Phe Glu Asp Leu Asn Ala Arg Glu 195 200 205 Val Gly Val Leu Ser Val Ile Leu Ala Phe Asp Leu Asn Phe Arg Asp 210 215 220 Leu Tyr Lys Ser Ala Phe Lys Thr Asp 225 230 INFORMATION FOR SEQ ID NO:504: SEQUENCE CHARACTERISTICS: LENGTH: 32 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .32 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:504 Val Glu Leu Ile Ser Asn Asn Pro Asn Ala Ser Gln Gln Ser Ile Val 1 5 10 Ile Pro Leu Glu Thr Phe Ala Leu Ala Arg Ala Leu Lys Gly Ile Phe 25 INFORMATION FOR SEQ ID NO:505: SEQUENCE CHARACTERISTICS: LENGTH: 171 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature t P; 'r F-4, PCT/US 9 6 /0 q 6IP DEC 1996 421 (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...99 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:507 Met Lys Glu Gin Glu Trp Asp Leu Ser Ala Leu Phe GIu Asn Lys Glu 1 5 10 Ser Ala Glu Glu Phe Leu Lys Thr Leu Gin Thr Glu Val Gin Glu Phe 25 Glu Asn Ala Tyr Gin Asn Asn Leu Lys Asn Leu Asp Ala Ala Lys Phe 40 Ala Asn Thr Leu Lys His Tyr Glu Asn Leu Ser Glu Lys Ile Ser Arg 55 Ala Met Ala Tyr Ala Asn Tyr Phe Leu Pro Arg Thr Leu Lys Lys Arg 70 75 Ser Phe Ile Arg Asn Ala Asn Gly Leu Cys Lys Tyr Pro Thr Thr Pro 90 Phe Ile Leu INFORMATION FOR SEQ ID NO:507: SEQUENCE CHARACTERISTICS: LENGTH: 99 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...99 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:507 Met Lys Glu Gln Glu Trp Asp Leu Ser Ala Leu Phe Glu Asn Lys Glu 1 5 10 Ser Ala Glu Glu Phe Leu Lys Thr Leu Gin Thr Glu Val Gin Glu Phe 25 Glu Asn Ala Tyr Gin Asn Asn Leu Lys Asn Leu Asp Ala Ala Lys Phe 40 Ala Asn Thr Leu Lys His Tyr Glu Asn Leu Ser Glu Lys Ile Ser Arg 55 Ala Met Ala Tyr Ala Asn Tyr Phe Leu Pro Arg Thr Leu Lys Lys Arg 70 75 Ser Phe Ile Arg Asn Ala Asn Gly Leu Cys Lys Tyr Pro Thr Thr Pro 90 Phe Ile Leu INFORMATION FOR SEQ ID NO:508: AMENDED~ SWI PCT/US 96/ 09 1 IPEA/US 18 DEC 1996 423 LENGTH: 70 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii)- HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...70 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:509 Val Arg Ser Gly Lys Arg Leu Gly Tyr Thr Asn Gin Val Ile Thr Asp 1 5 10 Ile Val Asn Ile Gly Ile Gly Gly Ser Asp Leu Gly Ala Leu Met Val 25 Cys Thr Ala Leu Lys Arg Tyr Gly His Pro Arg Leu Lys Met His Phe 40 Val Ser Asn Val Glu Trp His Ala Asp Phe Arg Arg Phe Gly Lys Asn 55 Gin Pro Gly Gin Arg Ala INFORMATION FOR SEQ ID NO:510: SEQUENCE CHARACTERISTICS: LENGTH: 130 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...130 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:510 Met Asn Leu Val Phe Leu Trp Ala Ala Leu Gly Gly Ala Ile Gly Ser 1 5 10 Ser Leu Arg Tyr Phe Val Gly Lys Met Met Pro Ser Lys Phe Leu Met 25 Phe Glu Ser Phe Pro Leu Gly Thr Phe Ser Val Asn Leu Ile Gly Cys 40 Phe Ile Ile Gly Phe Met Gly His Leu Ala Ala Lys Lys Val Phe Gly 55 Asp Asp Phe Gly Ile Phe Phe Val Thr Gly Val Leu Gly Gly Phe Thr 70 75 Thr Phe Ser Ser Tyr Gly Leu Asp Thr Leu Lys Leu Leu Gln Lys Ser 90 Gin Tyr Leu Glu Ala Ile Ser Tyr Val Leu Gly Thr Asn Leu Leu Gly 100 105 110 \Leu Ile Gly Val Ala Ile Gly Trp Phe Leu Ala Lys Asn Phe Val Gly 115 120 125 ,4;zz Ak~uncn~ *wrc? PCTUS 9 09 12 IPENUS 18 DEC1996 425 SEQUENCE CHARACTERISTICS: LENGTH: 79 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...79 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:512 Met Leu Glu Lys Leu Ile Glu Arg Val Leu Phe Ala Thr Arg Trp Leu 1 5 10 Leu Ala Pro Leu Cys Ile Ala Met Ser Leu Val Leu Val Val Leu Gly 25 Tyr Val Phe Met Lys Glu Leu Trp His Met Leu Ser His Leu Asn Thr 40 Ile Ser Glu Thr Asp Leu Val Leu Ser Ala Leu Gly Leu Val Asp Leu 55 Leu Val His Gly Arg Ala Cys Phe Asp Gly Ala Ala Arg Gin Leu 70 INFORMATION FOR SEQ ID NO:513: SEQUENCE CHARACTERISTICS: LENGTH: 102 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...102 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:513 Met His Tyr Gln Leu Thr Ser Phe Asn Ile Ile Gin Asp Leu Phe Ile 1 5 10 Thr Cys His Val Leu Arg Ile Lys Met Arg Val Phe Val Cys Phe Leu 25 Gly Val Phe Val Ser Asn Gly Leu Ala Arg Phe Gly Tyr Val Val Leu 40 Ile Pro Leu Leu Ile Leu Ser Gly Ser Leu Thr Pro His Gin Ser Phe 55 Gln Leu Gly Ile Ala Val Leu Met Gly Tyr Val Phe Gly Ser Phe Leu 70 75 Ile Gln Phe Leu Ser Pro Leu Met Ser Leu Lys Ser Ile Ala Lys Ile 90 Ser Phe Lys Leu Thr Leu 100 AMENDED SHEET, IPEAUS 18 DEC1996 427 145 150 155 160 Gly Leu Val Ala Arg Leu Ala Pro Phe Cys Lys Ser Thr Asn Gly Glu 165 170 175 Phe Gln Trp Leu Phe Asp Asn Lys Ala Thr Asp Arg Leu Asp Phe Ser 180 185 190 Lys Thr Ile Ile Gly Val Asp Gly Ser Ser Phe Leu Asp Asn Asn Asp 195 200 205 Val Ser Pro Phe Ile Cys Phe Tyr Leu Phe Ala Arg Ile Gln Glu Ala 210 215 220 Met Asp Gly Arg Arg Phe Val Leu Asp Ile Asp Glu Ala Trp Lys Tyr 225 230 235 240 Leu Gly Asp Pro Lys Val Ala Tyr Phe Val Arg Asp Met Leu Lys Thr 245 250 255 Ala Arg Lys Arg Asn Ala Ile Val Arg Leu Ala Thr Gin Ser Ile Thr 260 265 270 Asp Leu Leu Ala Cys Pro Ile Ala Asp Thr Ile Arg Glu Gin Cys Pro 275 280 285 Thr Lys Ile Phe Leu Arg Asn Asp Gly Gly Asn Leu Ser Asp Tyr Gin 290 295 300 Arg Leu Ala Asn Val Thr Glu Lys Glu Phe Glu Ile Ile Thr Lys Gly 305 310 315 320 Leu Asp Arg Lys Ile Leu Tyr Lys Gin Asp Gly Ser Pro Ser Val Ile 325 330 335 Ala Ser Phe Asn Leu Arg Gly Ile Pro Lys Glu Tyr Leu Lys Ile Leu 340 345 350 Ser Thr Asp Thr Val Phe Val Lys Glu Ile Asp Lys Ile Ile Gin Asn 355 360 365 His Ser Ile Ile Asp Lys Tyr Gin Pro 370 375 INFORMATION FOR SEQ ID NO:515: SEQUENCE CHARACTERISTICS: LENGTH: 377 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...377 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:515 Leu Ala Gln Pro Val Gln Val Arg Thr Val Phe Met Ser Met Thr Leu 1 5 10 Asn Ala Met Gly Gln Phe Ala Tyr Asn Phe Pro Ala Asn Ile Ser Lys 25 Asp Lys Gin Lys Leu Thr Met Val Tyr Met Asp Lys Asp Tyr Gly Ala 40 Tyr Gly Asn Ile Val Ala Met Gly Gly Glu Tyr Val Lys Ile Glu Leu 55 Gly Thr Asp Thr Gly Leu Asn Pro Phe Ala Trp Ala Ala Cys Val Gin 70 75 Lys Thr Asn Ala Thr Met Glu Gln Lys Gin Thr Ala Ile Ser Val Val 90 \Lys Glu Leu Val Lys Asn Leu Ala Thr Lys Ser Asp Glu Lys Asp Glu 100 105 110 PCT/US 9 09 12 IPEAIUS 8 D DEC01996 429 70 75 Tyr Asp Ala-Val Val Ile Ala His Thr His Leu Giu Leu Leu Ser Asn 90 Pro Arg Gly Ilie Ile Giu Giu Leu Lys Giu Giu Giu Leu Val Asn Ala 100 105 110 Giu Lys Asn Phe Giu Arg Gin Giu Leu Ala Ty'r Lys Asn Asn Pro Arg 115 120 125 Glu Thr Lys Lys Pro Asn Glu Arg Ala Phe Lys Asn Lys Leu Asp Lys 130 135 140 Ile Arg Ala Lys Tyr Asp Ala Ile Leu Giu Lys Gin Gly Ser His Ile 145 i50 155 160 Asp Ile Ser Gin Met Giy Ile Asp Asn Leu Ile Val Asp Giu Ala His 165 170 175 Leu Phe Lys Asn Leu Ala Phe Glu Thr Ser Met Giu Lys Ile Ala Gly 180 185 190 Leu Gly Asn Gin Gin Gly Ser Asn Arg Ala Arg Asp Leu Phe Ile Lys 195 200 205 Thr Arg Tyr Leu His Gin Asn Asp Lys Lys Ile Met Phe Leu Thr Gly 210 215 220 Thr Pro Ile Ala Asn Ser Leu Ser Glu Met Tyr His Leu Gin Arg Tyr 225 230 235 240 Leu Thr Pro Asp Val Leu Lys Giu Arg Gly Leu Glu Phe Phe Asp Asp 245 250 255 Trp Ala Lys Thr Tyr Gly Glu Val Val Asn Asp Phe Giu Leu Asp Thr 260 265 27U Ser Ala Gin Ser T'yr Lys Met Val Asn Arg Phe Ser Lys Phe Ser Asp 275 280 285 Val Gin Gly Leu Ser Thr Met Tyr Arg Ala Phe Ala Asp Ile Val Ser 290 295 300 Asn Asp Asp Ile Leu Lys His Asn Pro His Phe Val Pro Lys Val Tyr 305 310 315 320 Gly Asp Lys Pro Ilie Asn Val Val Val Lys Arg Ser Giu Glu Val Ala 325 330 335 Gin Ph Ilie Gly Val Ala Leu Glu Asn Gly Lys Tyr Asn Giu Gly Ser 340 345 350 Ile Ile Asp Arg Met Gin Lys Cys Glu Gly Lys Lys Ser Gin Lys Gly 355 360 365 Gin Asp Asn Ile Leu Ser Cys Thr Thr Asp Ala Arg Lys Val Ala Leu 370 375 380 Asp Tyr Arg Leu Ile Asp Pro Asn Ala Lys Val Giu Lys Giu Phe Ser 385 390 395 400 Lys Ser Tyr Ala Met Ala Lys Asn Ile Tyr Giu Asn Tyr Leu Glu Thr 405 410 415 His Ala Thr Lys Gly Thr Gin Leu Gly Ph. Ile Gly Leu Ser Thr Pro 420 425 430 Lys Thr His Ser Gin Lys Val Ser Leu Giu Ala Leu Asp Asn Ala His 435 440 445 Glu Thr Giu Asn Lys Asn Pro Leu Asp Lys Ala Gin Glu Leu Leu Giu 450 455 460 Ser Leu Ser Ser Tyr Asp Glu Lys Gly Asn Leu Ile Ala Pro Ser Lys 465 470 475 480 Lys Giu Leu Giu Asn Giu Leu Lys Glu Lys Giu Ala Lys Ser Val Asn 485 490 495 Leu Asp Glu Giu Ile Ala Lys Gly Cys Ser Phe Asp Val Tyr Ser Asp 500 505 510 Val Leu Arg His Leu Val Gin Met Gly Ile Pro Gin Asn Giu Ile Ala 515 520 525 Phe Ile His Asp Ala Lys Thr Giu Giu Gin Lys Gin Asp Leu Phe Lys 530 535 540 Lys Leu Asn Arg Gly Gly Val Arg Val Leu Leu Gly Ser Pro Ala Lys 545 550 555 560 Met Giy Val Gly Thr Asn Val Gin Glu Arg Leu Val Ala Met His Giu 565 570 575 SLeu Asp Cys Pro Trp Arg Pro Asp Glu Leu Leu Gin Met Giu Gly Arg 580 585 590 A a mrstmen CUef!rl 1PENUS 0 ~E C 1996 430 Gly Ile Arg Gin Giy Asn Ile Leu His Gin Asn Asp Pro Giu Asn Phe 595. 600 605 Arg Met Lys Ile Tyr Arg Tyr Ala Thr Glu Lys Thr Tyr Asp Ser Arg 610 615 620 Met Trp Gin Ile Ile Glu Thr Lys Ser Lys Gly Ile Giu Gin Phe Arg 625 630 635 640 Asn Ala-His Lys Leu Gly Leu Asn Glu Leu Glu Asp Phe Asn Met Gly 645 650 655 Ser Ser Asn Ala Ser Glu Met Lys Ala Glu Ala Thr Gly Asn Pro Leu 660 665 670 Ile Ile Giu Giu Vai Lys Leu Arg Ala Giu Ile Lys Ser Giu Giu Ser 675 680 685 Lys Tyr Lys Ala Phe Asn Lys Giu His Tyr Phe Asn Glu Giu Ser Leu 690 695 700 Lys Asn Asn Ala Ser Lys Leu Asp Tyr Leu Lys Gin Giu Leu Lys Asp 705 710 715 720 Leu Giu Thr Leu Gin Arg Ser Val Ilie Ile Pro Thr His Thr Giu Ile 725 730 735 Lys Leu Tyr Asp Leu Lys Asn Giu Giu Ser Lys Asp Tyr Giu Leu Ile 740 745 750 Lys Val Lys Giu Val Glu Pro Leu Lys Giu Asn Ala Ser Met Ser Giu 755 760 765 Giu Leu Thr His Lys Lys Leu Lys Giu Gin Asn Lys Gin Ile Ala Giu 770 775 780 Gin Asn Lys Giu Lys Leu Asp Ala Ile Lys Lys Gin Phe Ala Ser Asn 785 790 795 800 Leu Asn Thr Leu Phe Val Asn Giu Giu Giu Asp Tyr Lys Leu Leu Giu 805 810 815 Tyr Lys Gly Phe Vai Val Asn Ala Tyr Lys Thr Lys Tyr Gin Val Giu 820 825 830 Phe Ser Leu Ser Pro Lys Asp Asn Pro Asn Ile Ala Tyr Ser Pro Ser 835 840 845 Asn Met Val Tyr Lys Asn Asp Thr Ile Asn Met Phe Ser Ser Tyr Asn 850 855 860 Phe Cys Ala Giu Ile Lys Phe Asp Gly Phe Leu Lys Arg Leu Asp Asn 865 870 875 880 Ala Ile Thr Lys Leu Pro Giu Lys Ilie Lys Giu Leu Giu Asn Ser Ile 885 890 895 Giu Ile Thr Lys Lys Asn Ile Ala Lys Tyr Thr Arg Leu Val Giu Gin 900 905 910 Lys Pro Ser Tyr Pro Arg Leu Giu Tyr Leu Gin Ala Leu Lys Trp Asp 915 920 925 His Lys Thr Leu Ile Asp Asp Leu Ala Lys Met Ser Lys Asp Arg Asn 930 935 940 Tyr Lys Pro Ala Phe Asn Pro Lys Ser Lys Glu Val Leu Lys Asn Leu 945 950 955 960 Asn Ala Giu Lys Arg Ala Ser Leu Glu Asn Glu Arg Giu Giu Gin Gly 965 970 975 Val Lys Gly Asn Thr Lys Ser His Asp Giu Ile Glu Pro Ala Thr Giu 980 985 990 Gin Val Ile Glu Lys Giu Ile Glu Lys Gly Asp Giu Ile Ala Asn Asn 995 1000 1005 Val Asp Tyr Tyr Giu Asn Giu Gin Giu Val Giu Ile Thr Lys Ser Met 1010 1015 1020 Gly Arg Arg 1025 INFORMATION FOR SEQ ID NO:517: SEQUENCE CHARACTERISTICS: LENGTH: 154 amino acids TYPE: amino acid 4- TOPOLOGY: linear a, 4 IPEA/US 18 DEC1996 431 (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...154 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:517 Met Lys Leu Val Ser Leu Ile Val Ala Leu Val Phe Cys Cys Phe Leu 1 5 10 Gly Ala Val Glu Leu Pro Gly Val Tyr Gin Thr Gln Glu Phe Leu Tyr 25 Met Lys Ser Ser Phe Val Glu Phe Phe Glu His Asn Gly Lys Phe Tyr 40 Ala Tyr Gly Ile Ser Asp Val Unk Unk Ser Lys Ala Lys Lys Asp Lys 55 Leu Asn Pro Asn Pro Lys Leu Arg Asn Arg Ser Asp Lys Gly Val Val 70 75 Phe Leu Ser Asp Leu Ile Lys Val Gly Glu Gin Ser Tyr Lys Gly Gly 90 Lys Ala Unk Asn Phe Unk Asp Gly Lys Thr Unk His Val Arg Val Thr 100 105 110 Gin Unk Ser Asn Gly Asp Leu Unk Phe Thr Ser Ser Tyr Unk Lys Trp 115 120 125 Gly Tyr Val Gly Lys Thr Phe Thr Trp Lys Arg Leu Ser Asp Glu Glu 130 135 140 Ile Lys Asn Leu Lys 'Leu Lys Arg Phe Asn 145 150 INFORMATION FOR SEQ ID NO:517: SEQUENCE CHARACTERISTICS: LENGTH: 154 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii).HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...154 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:517 Met Lys Leu Val Ser Leu Ile Val Ala Leu Val Phe Cys Cys Phe Leu 1 5 10 Gly Ala Val Glu Leu Pro Gly Val Tyr Gln Thr Gin Glu Phe Leu Tyr 25 Met Lys Ser Ser Phe Val Glu Phe Phe Glu His Asn Gly Lys Phe Tyr 40 Ala Tyr Gly Ile Ser Asp Val Unk Unk Ser Lys Ala Lys Lys Asp Lys 55 Leu Asn Pro Asn Pro Lys Leu Arg Asn Arg Ser Asp Lys Gly Val Val 70 75 N O wmr~~, ~t4~1'1 IPEAUS io DEC 1996 432 Phe Leu Ser Asp Leu Ile Lys Val Gly Glu Gin Ser Tyr Lys Gly Gly 90 Lys Ala Unk Asn Phe Unk Asp Gly Lys Thr Unk His Val Arg Val Thr 100 105 110 Gin Unk Ser Asn Gly Asp Leu Unk Phe Thr Ser Ser Tyr Unk Lys Trp 115 120 125 Gly Tyr Val Gly Lys Thr Phe Thr Trp Lys Arg Leu Ser Asp Glu Glu 130 135 140 Ile Lys Asn Leu Lys Leu Lys Arg Phe Asn 145 150 INFORMATION FOR SEQ ID NO:518: SEQUENCE CHARACTERISTICS: LENGTH: 62 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...62 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:518 Met Ala Glu Glu Glu Lys Thr Glu Leu Pro Ser Ala Lys Lys Ile Gin 1 5 10 Lys Ala Arg Glu Glu Gly Asn Val Pro Lys Ser Met Glu Val Val Gly 25 Val Phe Arg Val Ile Gly Trp Ala Asn Glu Tyr Phe Cys Phe Phe Tyr 40 Met Val Gly Gly Met Ala Leu Ala Arg Cys Ile Ala Met Cys 55 INFORMATION FOR SEQ ID NO:519: SEQUENCE CHARACTERISTICS: LENGTH: 237 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...237 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:519 Met Lys Thr Leu Val Lys Asn Thr Ile Tyr Ser Phe Leu Leu Leu Ser 10 Nal Leu Met Ala Glu Asp Ile Thr Ser Gly Leu Lys Gln Leu Asp Asn Aa m c m n r. n FT PCT/US 9 6/09 12 IPEA/US 18 DEC1996 433 25 Thr Tyr Gln"Glu Thr Asn Gln Gln Val Leu Lys Asn Leu Asp Glu Ile 40 Phe Ser Thr Thr Ser Pro Ser Ala Asn Asn Lys Ile Gly Gln Glu Asp 55 Ala Leu Asn Ile Lys Lys Ala Ala Ile Ala Leu Arg Gly Asp Leu Ala 70 75 Leu Leu Lys Ala Asn Phe Glu Ala Asn Glu Leu Phe Phe Ile Ser Glu 90 Asp Val Ile Phe Lys Thr Tyr Met Ser Ser Pro Glu Leu Leu Leu Thr 100 105 110 Tyr Met Lys Ile Asn Pro Leu Asp Gin Lys Thr Ala Glu Gin Gln Cys 115 120 125 Gly Ile Ser Asp Lys Val Leu Val Leu Tyr Cys Glu Gly Lys Leu Lys 130 135 140 Ile Glu Gin Glu Lys Gln Asn Ile Arg Glu Arg Leu Glu Thr Ser Leu 145 150 155 160 Lys Ala Tyr Gln Ser Asn Ile Gly Gly Thr Ala Ser Leu Ile Thr Ala 165 170 175 Ser Gln Thr Leu Val Glu Ser Leu Lys Asn Lys Asn Phe Ile Lys Gly 180 185 190 Ile Lys Lys Leu Met Leu Ala His Asn Lys Val Phe Leu Asn Tyr Leu 195 200 205 Glu Glu Leu Asp Ala Leu Glu Arg Ser Leu Glu Gin Ser Lys Arg Gin 210 215 220 Tyr Leu Gln Glu Arg Gin Ser Ser Lys Ile Ile Val Lys 225 230 235 INFORMATION FOR SEQ ID NO:520: SEQUENCE CHARACTERISTICS: LENGTH: 83 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...83 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:520 Val Ser Giu Lys Asp Arg Ala Phe Leu Leu Ala Ser Leu Ser Cys Val 1 5 10 Asp Tyr Val Val Val Phe Gly Glu Asp Thr Pro Ile Lys Leu Ile Gin 25 Ala Leu Lys Pro Asp Ile Leu Val Lys Gly Ala Asp Tyr Leu Asn Lys 40 Glu Val Ile Gly Ser Glu Leu Ala Lys Glu Thr Arg Leu Ile Glu Phe 55 Glu Glu Gly Tyr Ser Thr Ser Ala Ile Ile Glu Lys Ile Lys Arg Thr 70 75 His Asn Asp INFORMATION FOR SEQ ID NO:521: 434 PEA/US i 0C 1996 SEQUENCE
CHARACTERISTICS:
LENGTH: 7 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...7 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:521 Leu Glu Thr Leu Phe Leu Val 1 INFORMATION FOR SEQ ID NO:521: SEQUENCE CHARACTERISTICS: LENGTH: 7 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...7 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:521 Leu Glu Thr Leu Phe Leu Val 1 INFORMATION FOR SEQ ID NO:522: SEQUENCE CHARACTERISTICS: LENGTH: 64 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: 14 NAME/KEY: misc feature LOCATION 1...64 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:522 AIIcumnl QUi:TJ PCT/US 9 6 0 1 IPEA/US 18 OEC 1996 435 Val Tyr Asp Lys Ser Leu Cys Lys Thr Met Ala Leu Ala Leu Lys Ala 1 5 10 Leu Gly Val Lys Arg Ala Met Val Val Asn Gly Gly Gly Thr Gly Glu 25 Ile Val Leu His Asp Ile Thr His Ala Cys Glu Leu Lys Asn Asn Glu 40 Ile Leu Glu Tyr Asp Leu Ser Ala Lys Asp Phe Asp Leu Pro Pro Ser 55 INFORMATION FOR SEQ ID NO:523: SEQUENCE
CHARACTERISTICS:
LENGTH: 228 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...228 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:523 Met Leu Val Glu Ile Glu Asn Leu Thr Lys Thr Tyr Gly Ser Leu Lys 1 5 10 Ala Leu Asp Asn Ile Ser Leu Lys Leu Pro Lys Gln Gln Phe Ile Gly 25 Leu Leu Gly Pro Asn Gly Ala Gly Lys Thr Thr Leu Leu Lys Ile Leu 40 Ala Gly Leu Asn Leu Asn Tyr Gln Gly Glu Val Lys Ile Leu Asn Gin 55 Lys Ile Gly Ile Glu Thr Lys Lys Ser Val Ala Phe Leu Ser Asp Gly 70 75 Asp Phe Leu Asp Pro Lys Leu Thr Pro Leu Lys Ala Ile Ala Phe Tyr 90 Lys Asp Phe Phe Ser Asp Phe Asp Glu Ser Lys Ala Leu Asn Leu Leu 100 105 110 Lys Arg Phe Ser Val Pro Leu Lys Arg Glu Phe Lys Ala Leu Ser Lys 115 120 125 Gly Met Arg Glu Lys Leu Gln Leu Ile Leu Thr Leu Ser Arg Asn Ala 130 135 140 Ser Leu Tyr Leu Phe Asp Glu Pro Val Ala Gly Ile Asp Pro Ile Ala 145 150 155 160 Arg Glu Glu Ile Phe Giu Leu Ile Ala Lys GIu Phe Ser Gln Asn Ala 165 170 175 Ser Leu Leu Val Ser Thr His Leu Val Val Asp Val Glu Lys Tyr Leu 180 185 190 Asp Ser Ala Ile Phe Leu Lys Glu Ala Lys Val Val Ala Phe Gly Asp 195 200 205 Val Gly GIu Leu Lys Lys Gly Tyr Ser Ser Leu Glu Ala Ala Tyr Lys 210 215 220 Glu Arg Leu Lys 225 INFORMATION FOR SEQ ID NO:524: L U ULiJ SEQUENCE CHARACTERISTICS: LENGTH: 273 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .273 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:524 Met Asn Lys Leu Phe Leu Ala Phe Ile Val Gly Gly 1 Ala Tyr Asp Leu Leu Sen I le Lys Ang 145 Trp Ala Lys Asn Lys 225 Leu Asn Pro Asp His Phe Lys Lys Ile Arg Thr 130 His Glu Leu Tyr As n 210 Ile Asn Pro.
Ala Leu Met Asn Tyr Glu Glu Asn Ile Thr Asn Asn 100 Met Gin 115 Glu Tyr Gly Phe Tyr Asp Val Leu 180 Trp Leu 195 pro Leu Ile Gin Leu Leu Ile Ile 260 5 Asn Lys Met Gly Phe Sen Sen Val1 Asp Phe 165 Sen Ser Trp Ile Asp 245 Leu Asp Leu Gly Leu 70 Lys Leu Sen Leu Phe 150 Ala Sen Val Gin Ile 230 G ly Lys Lys Phe Arg Leu Ala As n Ser Asp 135 Met Leu Asp Asn Pro 215 Ala Val Asn Ile Glu 25 Leu Glu 40 Leu Asp Ser Phe Ser Sen Met Met 105 Gly Glu 120 Pro Asn Asp Ile Gin Lys Pro Val 185 Gin Asn 200 Lys Ile Lys Glu Ang Phe Gly Ile 265 10 Asn Leu Arg Leu Ser Leu Asn Phe 75 Asn Pro 90 Gly Tyr Asn Val Ile Leu Ang Arg 155 Ile Lys 170 Giu Phe Ala Tyr Ile Phe Asn Arg 235 Ile His 250 Sen Val Met Phe Lys Asp Leu Ser Phe I le 140 Val1 Leu Lys Leu Tyr 220 Gin Ile Val Met Gly Lys Leu Lys Ala Tyr Ser 125 Giu Sen Pro Giu Lys 205 Asp Gin Thr Phe Leu Glu Asn Leu Pro Phe Val1 110 Tyr Thr Leu Asn Ala 190 Ile Giu G iu Asp Asp 270 Leu is Arg Arg Asn Ser Ala Leu Glu Met Lys Ala 175 Ser Ser Asn Ile Ala 255 Ala Ser Ser Lys Thn Val Lys Pro Leu Lys Glu 160 Arg Gly Ser Leu Ala 240 Lys Met INFORMATION FOR SEQ ID NO:525: SEQUENCE CHARACTERISTICS: LENGTH: 15 amino acids TYPE: amino acid TOPOLOGY: linear i)MOLECULE TYPE: protein iAPIun;fl qI4FFT 437 IPEA/US 18 DEC 1996 (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...15 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:525 Val Ser Arg Pro Phe Lys Thr Ile Lys Lys Pro Pro Gln Pro Pro 1 5 10 INFORMATION FOR SEQ ID NO:526: SEQUENCE CHARACTERISTICS: LENGTH: 114 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...114 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:526 Met Unk Thr His Asp Arg Arg Lys Leu Arg Ile Unk Leu Thr Gln Thr 1 5 10 Thr Thr Leu Val Ala Thr Ile Gly Ser Asn Ala Pro Tyr Ile Gly Leu 25 Leu Gly Thr Val Met Gly Ile Met Leu Thr Phe Met Asp Leu Gly Ser 40 Ala Ser Gly Ile Asp Thr Lys Ala Ile Met Thr Asn Leu Ala Leu Ala 55 Leu Lys Ala Thr Gly Met Gly Leu Leu Val Ala Ile Pro Ala Ile Val 70 75 Ile Tyr Asn Leu Leu Val Arg Lys Ser Glu Ile Leu Val Thr Lys Trp 90 Asp Ile Phe His His Pro Val Asp Thr Gln Ser His Glu Val Tyr Ser 100 105 110 Lys Ala INFORMATION FOR SEQ ID NO:526: SEQUENCE CHARACTERISTICS: LENGTH: 114 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: 'AMFNuED SHEET, IPEA/US 18 DEC1996 438 ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...114 (xi)-SEQUENCE DESCRIPTION: SEQ ID NO:526 Met Unk Thr His Asp Arg Arg Lys Leu Arg Ile Unk Leu Thr Gln Thr 1 5 10 Thr Thr Leu Val Ala Thr Ile Gly Ser Asn Ala Pro Tyr Ile Gly Leu 25 Leu Gly Thr Val Met Gly Ile Met Leu Thr Phe Met Asp Leu Gly Ser 40 Ala Ser Gly Ile Asp Thr Lys Ala Ile Met Thr Asn Leu Ala Leu Ala 55 Leu Lys Ala Thr Gly Met Gly Leu Leu Val Ala Ile Pro Ala Ile Val 70 75 Ile Tyr Asn Leu Leu Val Arg Lys Ser Glu Ile Leu Val Thr Lys Trp 90 Asp Ile Phe His His Pro Val Asp Thr Gln Ser His Glu Val Tyr Ser 100 105 110 Lys Ala INFORMATION FOR SEQ ID NO:527: SEQUENCE CHARACTERISTICS: LENGTH: 67 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...67 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:527 Met Ile Ala Val Leu Pro Pro Leu Phe Ser Met Gly Ser Phe Asp Glu 1 5 10 Trp Ile Tyr Arg Gly Leu Val Ala Leu Met Val Ser Cys Pro Cys Ala 25 Leu Val Ile Ser Val Pro Leu Gly Tyr Phe Gly Gly Val Gly Ala Ala 40 Ser Arg Lys Gly Ile Leu Met Lys Gly Val His Val Leu Glu Gly Ala 55 Tyr Pro Asn INFORMATION FOR SEQ ID NO:528: SEQUENCE CHARACTERISTICS: LENGTH: 323 amino acids S(B) TYPE: amino acid TOPOLOGY: linear F A a SPf-aig-f %1 Irt PCT/US 96 0 1 IPEA/U 1o ur-c.u 439 (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...323 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:528 Val Gln His Phe Asn Phe Leu Tyr Lys Asp Ser Leu 1 Leu Ala Gin Lys Lys Arg Lys Lys Leu 145 Thr Lys Ala Ala Ile 225 Met Ile Phe Ser Phe Tyr Asn His Ala Pro Asn Glu 130 Leu Leu Asn Lys Leu 210 Asp Asn Ala Glu Leu Thr Phe Gin Ala Asp Leu Tyr 115 Ile His Glu Tyr Ile 195 Asn Thr Ile Arg Leu 275 Thr Phe Thr Asn Lys Val Lys 100 Phe Leu Ala Cys Leu 180 Leu His Thr Pro Ser 260 Glu Phe 5 Ile Arg Ala Ile Glu Asp Ser Arg Tyr Leu 165 Tyr His Leu Glu Ala 245 Gin Val Glu Ile Lys Tyr Ser 70 Met Glu Val Phe Glu 150 Glu Leu Val Lys Arg 230 Phe Gly Leu Tyr Ala Arg Ala 55 Ser Ser Glu Gly Ser 135 Leu Glu Met Ser Ser 215 Leu Ile Leu Arg Arg 295 Leu Asn 40 Ser Leu Ile Lys Tyr 120 Pro Glu Leu His Lys 200 His Glu Leu Leu Ala 280 Cys Val 25 Lys Ser Met Glu Ile 105 Leu Arg Lys Glu Leu 185 Ala Asp Asn Glu Leu 265 Leu Lys 10 Ile Lys Glu Phe Ile 90 Ala Gin Asn Asp Val 170 Ile Ser Glu Val Lys 250 Asp Leu His Leu Phe Asn Leu 75 Leu Val Lys Val Tyr 155 Pro Glu Leu Asn Ile 235 His His His Cys Leu Leu Leu Ala Lys Leu Thr Glu 140 Ser Lys Asn Asp Leu 220 Asp Ala Lys Ser Lys 300 Phe Glu Gin Asp Arg Gly Asp Lys 125 Ala Lys Ile Lys Leu 205 Phe Leu Leu Pro Pro 285 Gin Ser Gln Lys Glu Ala Leu Leu 110 Asp Leu Ala Glu Glu 190 Lys Trp Leu Leu Cys 270 Ile Ile Ile Ala Phe Leu Tyr Leu Leu Thr Leu Leu Thr 175 Asp Lys Gin Trp Gin 255 Gin Lys Phe Ala Arg Ala Leu Ser Asn Ala Val Lys Glu 160 Ile Ala Ile Glu Asp 240 Asp Ile Ala Pro Asp 320 290" Phe Glu Ser His Arg Cys 305 310 Met Val Ala Pro Val Cys Tyr Gln Leu Ala Phe Met 315 INFORMATION FOR SEQ ID NO:529: SEQUENCE CHARACTERISTICS: LENGTH: 10 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein IPENUS 18 DEC 1996 440 (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...10 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:529 Met Glu His Leu Thr Arg Gly Ile Lys His 1 5 INFORMATION FOR SEQ ID NO:530: SEQUENCE CHARACTERISTICS: LENGTH: 12 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...12 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:530 Val Val Ile Leu Gly Ser His Gly Lys Glu Glu Tyr 1 5 INFORMATION FOR SEQ ID NO:531: SEQUENCE CHARACTERISTICS: LENGTH: 79 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...79 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:531 Met Lys Lys Val Ile Val Ala Leu Gly Val Leu Ala Phe Ala Asn Val 1 5 10 Leu Met Ala Thr Asp Val Lys Ala Leu Val Lys Gly Cys Ala Ala Cys 25 "\His Gly Val Lys Phe Glu Lys Lys Ala Leu Gly Lys Ser Lys Ile Val PCT/US 9 6 O 441 40 Asn Met Met'Ser Glu Lys Glu Ile Glu Glu Asp Leu Met Ala Phe Lys 55 Ser Gly Ala Asn Lys Asn Pro Val Met Thr Arg Lys Leu Lys Asn 70 INFORMATION FOR SEQ ID NO:532: SEQUENCE CHARACTERISTICS: LENGTH: 95 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_ feature LOCATION 1...95 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:532 Met Gly Ile Ala Thr Ser Leu Ile Ser Glu Val Ser Lys Phe Tyr Tyr 1 5 10 Ala Leu Lys Tyr His Ala Lys Phe Met Ser Leu Gly Glu Leu Gly Cys 25 Tyr Ala Ser His Tyr Ser Leu Trp Gln Lys Cys Ile Glu Leu Asn Glu 40 Ala Ile Cys Ile Leu Glu Asp Asp Ile Thr Leu Lys Glu Asp Phe Lys 55 Glu Gly Leu Asp Phe Leu Glu Lys His Ile Gln Glu Leu Gly Tyr Ala 70 75 Arg Leu Met His Leu Leu Tyr Asp Ala Ser Val Lys Ser Glu Pro 90 INFORMATION FOR SEQ ID NO:533: SEQUENCE CHARACTERISTICS: LENGTH: 154 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...154 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:533 Met His Leu Lys Ser Gly Ala Val Phe Ile Ser Asp Ala His Phe Leu 1 5 10 Pro Lys Ser Pro His Leu Ile His Thr Leu Lys Glu Leu Leu Ser Ala x 20 25 P& 107, S IPEA/US 18 DEC1996 442 Lys Pro Pro Gin Val Phe Phe Met Gly Asp Ile Phe His Val Leu Val 40 Gly Tyr Leu Pro Leu Asp Lys Glu Gin Gln Lys Ile Ile Asp Leu Ile 55 His Ala Leu Ser Glu Ile Ser Gin Val Phe Tyr Phe Glu Gly Asn His 70 75 Asp Phe -Ser Met Arg Phe Val Phe Asn Ser Lys Val Met Val Phe Glu 90 Arg Gin Asn Gln Pro Ala Leu Phe Gin Tyr Asp Asn Lys Arg Phe Leu 100 105 110 Leu Ala His Gly Asp Leu Phe Ile Thr Lys Ala Tyr Glu Phe Tyr Ile 115 120 125 Thr Gin Leu Thr Ser Thr Trp Ala Arg Phe Phe Leu Thr Phe Leu Asn 130 135 140 Leu Leu Ser Phe Lys Thr Leu Tyr Pro Phe 145 150 INFORMATION FOR SEQ ID NO:534: SEQUENCE CHARACTERISTICS: LENGTH: 67 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...67 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:534 Met Gln Asp Leu Asp Asn Asn Met Ser Leu Asp Thr Ala His Asn Thr 1 5 10 Leu Ser Ser Asn Gly Lys Asn Ile Thr Ile Ala Gly Val Val Lys Ala 25 Leu Gin Lys Ile Gly Val Ser Ala Lys Gly Met Val Ser Ile Leu Gin 40 Ala Leu Lys Lys Ser Gly Ala Ile Ser Ala Lys Trp Arg Tyr Tyr Asp 55 Lys Gin Gin INFORMATION FOR SEQ ID NO:534: SEQUENCE CHARACTERISTICS: LENGTH: 67 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: aAAFr~Mrfl SHEEF 1 443 NAME/KEY: misc_feature LOCATION 1...67 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:534 Met Gin Asp Leu Asp Asn Asn Met Ser Leu Asp Thr Ala His Asn Thr 1 5 10 Leu Ser Ser Asn Gly Lys Asn Ile Thr Ile Ala Gly Val Val Lys Ala 25 Leu Gln Lys Ile Gly Val Ser Ala Lys Gly Met Val Ser Ile Leu Gin 40 Ala Leu Lys Lys Ser Gly Ala Ile Ser Ala Lys Trp Arg Tyr Tyr Asp 55 Lys Gln Gin INFORMATION FOR SEQ ID NO:535: SEQUENCE CHARACTERISTICS: LENGTH: 313 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...313 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:535 Val Gin Pro Met Lys Ser Lys Lys Leu Tyr Leu Ala Leu Ile Ile Gly 1 5 10 Val Leu Leu Ala Phe Leu Thr Leu Ser Ser Trp Leu Gly Asn Ser Gly 25 Leu Val Gly Arg Phe Gly Val Trp Phe Ala Ala Ile Asn Lys Lys Tyr 40 Phe Gly Tyr Leu Ser Leu Ile Asn Leu Pro Tyr Leu Ala Trp Val Leu 55 Phe Leu Leu Tyr Arg Ala Lys Asn Pro Phe Thr Glu Ile Val Leu Glu 70 75 Lys Thr Leu Gly His Leu Leu Gly Ile Leu Ser Leu Leu Phe Leu Gin 90 Ser Ser Leu Leu Asn Gin Gly Glu Ile Gly Asn Ser Ala Arg Leu Phe 100 105 110 Leu His Pro Phe Ile Gly Asp Phe Gly Leu Tyr Val Leu Ile Met Leu 115 120 125 Met Val Val Ile Ser Tyr Leu Ile Leu Phe Lys Leu Pro Pro Lys Ser 130 135 140 Val Phe Tyr Pro Tyr Met Asn Lys Thr Gln Ser Leu Leu Lys Glu Ile 145 150 155 160 Tyr Lys Gln Cys Leu Gln Ala Phe Ser Pro Asn Phe Ser Leu Lys Lys 165 170 175 Glu Gly Phe Glu Asn Thr Pro Ser Asp Ser Gln Lys Lys Glu Thr Asn 180 185 190 Asn Asp Lys Glu Lys Glu Asn Leu Lys Glu Asn Pro Ile Asp Glu Asn 195 200 205 is Asn Thr Pro Asn Glu Glu Ser Phe Leu Ala Ile Pro Thr Pro Tyr 210 215 220 'AMENDED SHEETi pOT/US 96/09122 KAMNU 18 DEC 1996 Asri 225 Ser Phe Lys Pro Lys 305 Thr Leu His Pro Asp Leu 260 Arg Giu 275 Met Pro Thr Lys Asn Pro 245 Thr* Pro Ile Pro Asn 230 Thr Asn Thr Ser Leu 310 Pro Thr Leu 265 Lys Thr Pro 444 Gin Giu Gly 235 Ile Tyr Pro 250 Lys Giu Pro Giu Thr Pro Gin Lys Ile 300 Leu Vai Lys Arg Lys Gin 270 Thr Thr 285 Met Thr INFORMATION FOR SEQ ID NO:536: SEQUENCE CHARACTERISTICS: LENGTH: 3i9 amino acids TYPE:.amino acid TOPOLOGY: iinear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc-feature LOCATION .319 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:536 iVal Met Leu Ser Arg Asp Ile Vai Gin Tyr Sen Lys Ile Arg Thr Giu Le Leu Gin Gly G iu His Lys Leu Ala 145 Ser Met Phe Sen Ala Tyr Pro Ala Met G iy Val Arg Val1 130 Phe Ser Tyr Val1 Phe 210 Leu Ala Glu Giu Leu Leu Ser Cys 115 Val1 Val Pro Phe Lys 195 Asp Ala Tyr 20 Ile Ile Met Leu Ph.
100 Ile Ser Val Ser Met 180 Cys Ile Thr 5 Leu Thr Lys Leu Giu Ser Leu Ala Cys Lys 165 Ile Ile Lys Ph.
Thr Leu Met Lys 70 His Asp Thr Ser Leu 150 Tyr Sen Ser Giu Asp 230 Tyr Leu Asp Tyr 40 Ala Lys 55 Pro Sen Asp Leu Lys Tyr Asp Pro 120 Tyr Pro 135 Gin Ile Phe Lys Ile Met Ser Phe 200 Val Phe 215 Leu Val Asp Asn Phe Leu Se r Gin Thr Tyr 105 Tyr Val1 Pro Thr Leu 185 Trp His Lys Sen Asn Phe Phe Giu 90 Phe Pro Tyr Leu Phe 170 Thr Thr Pro Ala His Arg Ph.
Lys 75 Gly Tyr Ser Asp Arg 155 Ser Leu Ala Ile Ile Asn Gin Val1 Giu Ile Gin Lys Gin 140 Val Giu Val1 Sle *Val 220 *Phe Ile Leu Gin Glu Aia' Lys 125 Asn Ala Gly Ser Val1 205 Leu Glu krg ;er ksp Giy Leu VJal 110 Gly Asn Ile Ser Leu 190 His Leu G iu Asn Lys Ala His Giu Asn Asn Asp Giu Met 175 Leu Ph.
Thr Giu His Met Lys Lys Sen Giu His Leu Ile 160 Val Leu Ser Leu Val 240 235 Gly Lys Asn Ser Gly Gly ys An Se GlyHis His Ala Ile His Arg Thr Met PGT/US 9 6 09 12 IPEAUS 18 EC 1996 445 245 250 255 Ile Arg Phe Leu Gly Ser Ile Ile Ile Ala Leu Ala Ile Glu Ala Leu 260 265 270 Met Leu Val Phe Lys Phe Ser Val Ser Glu Pro Asp Lys Ile Thr Tyr 275 280 285 Ala Val Tyr Leu Ala Ile Gly Val Ala Val Leu Leu Ile Ser Leu Ala 290- 295 300 Ile Tyr Val Lys Phe Ala Tyr Ser Val Leu Pro Lys Arg Glu Arg 305 310 315 INFORMATION FOR SEQ ID NO:537: SEQUENCE CHARACTERISTICS: LENGTH: 118 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION 1...118 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:537 Met Val Ile His Glu Lys Ile Lys Ser Arg Phe Ser Arg Asn Trp Ser 1 5 10 Leu Arg Asn Arg Gly Arg His Phe Ala Ser Ser Ser Val Tyr Phe Phe 25 Ser Leu Leu Val Ile Thr Ala Val Asn Arg Ser Ser Ala Val Ala Trp 40 Leu Leu Met Pro Glu His Leu Ile Gly Trp Phe Leu I.1e Ser Phe Ser 55 Gly Glu Phe Val Ala Asp Met Ala Phe Gly Lys Lys Ser Lys Ile Phe 70 75 Lys Thr Arg Phe Gly Ile Ser Ile Val Ser Gly Val Ser Leu Leu Leu 90 Gly Ala Tyr Gln Arg Phe Tyr Phe Leu Tyr Gly Leu Ala Leu Leu Ile 100 105 110 Gly Gly Leu Ser Phe Leu 115 INFORMATION FOR SEQ ID NO:538: SEQUENCE CHARACTERISTICS: LENGTH: 88 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature PCT/US 96/ 09 1 IPEA/US 8 DEC1996 Leu 1 Leu Asn Ile His Phe LOCATION 1...88 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:538 His Pro Leu Ala Asp Val Phe Val Val Asn Asp Lys Arg Unk Val 5 10 Ala Met Val Unk Met Leu Ile Unk Ser Leu Ala Asn Ile Phe Phe 25 Tyr Leu Phe Ile Phe Unk Leu Glu Val Gly Val Gin Gly Unk Ala 40 Val Thr Val Ile Gly His Ala Ile Gly Gly Leu Val Leu Met Gin 55 Phe Trp Arg Lys Lys Gly Glu Leu Tyr Phe Ile Lys Leu Ile Phe 70 75 Ile Phe Ser His Phe Phe Ser INFORMATION FOR SEQ ID NO:538: SEQUENCE CHARACTERISTICS: LENGTH: 88 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...88 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:538 Leu His Pro Leu Ala Asp Val Phe Val Val Asn Asp Lys Arg Unk Val 1 5 10 Leu Ala Met Val Unk Met Leu Ile Unk Ser Leu Ala Asn Ile Phe Phe 25 Asn Tyr Leu Phe Ile Phe Unk Leu Glu Val Gly Val Gin Gly Unk Ala 40 Ile Val Thr Val Ile Gly His Ala Ile Gly Gly Leu Val Leu Met Gin 55 His Phe Trp Arg Lys Lys Gly Glu Leu Tyr Phe Ile Lys Leu Ile Phe 70 75 Phe Ile Phe Ser His Phe Phe Ser INFORMATION FOR SEQ ID NO:539: SEQUENCE CHARACTERISTICS: LENGTH: 92 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori ^I to-f-qp PCT/US 96/091 2 IPEAJIS 18 DEC 1996 Met 1 Val Leu Tyr Glu Ala (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...92 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:539 Phe Lys Ser Arg Leu Asn Ser Trp Ile Leu I 5 10 Leu Val Val Val Phe Trp Asp Val Ile Lys 25 Gin His Asp His Tyr Leu Ser Gln Val Lys 40 Lys Asn His Ile Glu Glu Ala Leu Lys Lys Lys Gly Gly Asp Lys Val Asp Cys Ser Ala 70 75 Gly Glu Arg Asn Arg Arg Met Leu Glu Ile 1 Gly Ile Leu Lys Ile Glu Arg Glu Glu Ser Glu Cys Met Arg Ile Gly Asp Tyr Phe Ala INFORMATION FOR SEQ ID NO:540: SEQUENCE CHARACTERISTICS: LENGTH: 138 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...138 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:540 Met Val Phe Trp Gly Ala Val Phe Phe Leu Trp Asp Arg Thr 1 Lys Arg Leu Ser Thr Thr Gly Phe Val Gin Asn Gin Leu Ile Ser Ser 130 Leu Leu Gin Val Ile Met Ala 115 Leu Met Gly Ile Trp Val His 100 Ile Lys 5 Val Ser Val Pro Pro Ala Phe Lys Phe Phe Leu Phe 70 Ala Glu Ile Ala Leu Leu Ile 55 Glu Tyr Phe Val Cys 135 Asn Gly 40 Ser Ser His Ile Ser 120 Glu 10 Ser Leu 25 Ala Trp Ser Leu Leu Pro Gly Ile 90 Asp Val 105 Phe Ile Asn Ala Unk Ile Pro Ser 75 Ser Ser Gly Unk Lys Leu Tyr Leu Ile Cys Met Asn Ile Leu Leu His Val 125 Leu Glu Phe Gin Gly Phe 110 Phe Ala Ala Ala Met Val Arg Tyr Lys Trp Ala His Met Phe Leu Ala Leu INFORMATION FOR SEQ ID NO:541: SEQUENCE CHARACTERISTICS: LENGTH: 276 amino acids IA. 0% 40, NrW PCT/US 9 6 0 9 1 2 IPEAUS 18 DEC 1996 448 TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...276 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:541 Met Leu Arg Lys Asn Ile Leu Ala 1 Ile Ser Ser Leu Ala Leu Ile Ser Ile 145 Leu Ile Leu Asp Val 225 Gin Val Lys Ile Lys Phe Met Ser Ala Glu Lys 130 Gly Tyr Ile Lys Asn 210 Phe Gly Ile Lys Ala Gly Cys Ser Phe Trp Ala 115 Phe Ser Val Tyr Leu 195 Pro Phe Val Ser Ser 275 Gin Leu Val Arg Ser Gly 100 Ser Leu Ser Val Phe 180 Leu Lys Met Lys Ile 260 Pro 5 Ser Ser Leu Lys Leu Leu Leu Ala Leu Gly 165 Lys Lys Leu Ser Glu 245 Pro Leu Leu Val Asn 70 Val Tyr Ile Lys Gly 150 Ile Glu Glu Lys His 230 Gin His Pro Ser Ala 55 Leu Leu Gly Thr Asn 135 Ser Phe Lys Gin Ile 215 Phe Tyr Ser His Glu 40 Glu Phe Phe Leu Asp 120 Asn Phe Leu Glu Val 200 Leu Gin Leu Phe Tyr Tyr 10 Ala Ile 25 Ile Leu Tyr Pro Leu Val Phe Asp 90 Tyr Ser 105 Ile Lys Gin Ile Leu Tyr Ile Met 170 Gly Asp 185 Lys Gly Leu Val Met Trp Phe Val 250 Phe Lys 265 Gly Ala Asn Leu Thr Pro Leu Val Gin Ser Gly Val Ser Asn Val 75 Ser Phe Ile Ala Cys Ser Glu Asn Lys 125 Thr Tyr Leu 140 Leu Lys Val 155 Leu Cys Ala Phe Lys Ser Ser Leu Lys 205 Gly His Leu 220 Gin Ala Tyr 235 Phe Tyr Ile Phe Leu Thr Leu Phe Leu Ser 110 Lys Gly His Leu Gin 190 Glu Ile Phe Ala Leu Leu Phe Ala Leu Met Gly Asp Met Ala Thr 175 Lys Leu Thr Leu Phe Leu Leu Phe Asp Ile Leu Thr Leu Ile Met 160 Ile Asn Lys Pro Lys 240 Gin Ser Gln Lys 255 Leu Unk Ala 270 INFORMATION FOR SEQ ID NO:541: SEQUENCE CHARACTERISTICS: LENGTH: 276 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES IP&Wj4tS 18 DEC 1996 449 (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .276 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:541 Met Leu Arg Lys Asn Ile Leu Ala 1 Ile Ser Ser Leu Ala Leu Ile Ser Ile 145 Leu Ile Leu Asp Vali 225 Gin Val1 Lys Ile Lys Phe Met Ser Ala Glu Lys 130 Gly Tyr Ile Lys As n 210 Phe Giy Ile Lys Ala Giy Cys Ser Phe Trp Ala 115 Phe Ser Val1 Tyr Leu 195 Pro Phe Val1 Ser Ser 275 Gin Leu Val1 Arg Ser Gly 100 Ser Leu Ser Val1 Phe 180 Leu Lys Met Lys Ile 260 Pro 5 Ser Ser Leu Lys Leu Leu Leu Ala Leu Gly 165 Lys Lys Leu Ser Giu 245 Pro Leu Leu Val1 Asn 70 Val1 Tyr Ile Lys Gly 150 Ile Giu Glu Lys His 230 Gin His His Giu 40 Glu Phe Phe Leu Asp 120 Asn Phe Leu Giu Val1 200 Leu Gin Leu Phe Tyr Ala 25 Ile Tyr Leu Phe Tyr 105 Ile Gin Leu Ile Gly 185 Lys Leu Met Phe Phe 265 Tyr 10 Ile Leu Pro Val1 Asp 90 Ser Lys Ile Tyr Met 170 Asp Gly Val1 Trp Val1 250 Lys Gly Ala Asn Leu Thr Pro Leu Val Gin Ser Gly Val Ser Asn Val 75 Ser Phe Ile Ala Cys Ser Giu Asn Lys 125 Thr Tyr Leu 140 Leu Lys Val 155 Leu Cys Ala Phe Lys Sen Ser Leu Lys 205 Gly His Leu 220 Gin Ala Tyr 235 Phe Tyr Ile Ser Gin Lys Phe Leu Thr Leu Phe Leu Ser 110 Lys Gly His Leu Gin 190 Glu Ile Phe Ala Leu 270 Lou Leu Phe Ala Leu Met Gly Asp Met Ala Thr 175 Lys Leu Thr Leu Ph.
255 Unk Leu Leu Phe Asp Ile Leu Thr Leu Ile Met 160 Ile Asn Lys Pro Lys 240 Gin Ala INFORMATION FOR SEQ ID NO:542: SEQUENCE CHARACTERISTICS: LENGTH: 254 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .254 AMFNflFf q, FT IP AiJS 18 DEC1996 450 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:54 2 Met His Glu Gin Gly Ser Ile Ser Phe Ile Gly Glu Gln Gly Ala Lys 1 5 10 Arg Leu Leu Tyr Ile Leu Tyr Lys Leu Ala Phe Asn Ala Lys Ser Asn 25 Lys Ile Ala Leu Asp Arg His Tyr Ala Lys Met Phe Leu Gin Val Val 40 Ala Arg Thr Leu Ile Lys Asn Val Asn Ile Leu Glu Glu Gin Gly Phe 55 Ile Glu Val Ile Lys Gly Lys Gln Arg Tyr Leu Tyr Val Tyr Leu Lys 70 75 Asp Tyr Arg Giu Leu Glu Cys Leu Val Lys Ser Lys Met Ala Lys Tyr 90 Val Met Tyr Leu Arg Gin Phe Phe Asp Tyr Leu Asp Arg Lys Arg Arg 100 105 110 Tyr Gly Phe Asp Phe Thr Leu Lys Asn Leu Ala Phe Ala Lys Thr Lys 115 120 125 Glu Ser Leu Pro Arg His Leu Asn Asp Lys Asp Leu Lys Ser Phe Leu 130 135 Lys Thr Leu Leu Asp Tyr Lys Pro Ala Thr Ser 2he Glu Lys Arg Asn 145 150 155 160 Lys Cys Ile Leu Leu Ile Val Ile Leu Gly Gly Leu Arg Lys Cys Glu 165 170 175 Val Leu Asn Ile Glu Leu Lys His Ile Gin Val Glu Glu Gln Asn Tyr 180 185 190 Ser Ile Leu Ile Gin Gly Lys Gly Arg Lys Glu Arg Lys Ala Tyr Ile 195 200 205 Lys Lys Ser Leu Leu Glu Pro Ser Leu Asn Ala Trp Ile Ser Asp Asp 210 215 220 Tyr Arg Leu Lys Tyr Phe Asn Gly Ala Tyr Leu Phe Lys Lys Asp Lys 225 230 235 240 Gin Lys Ser Gln Asn Ser Leu Thr Leu Tyr Asn Leu Ser Pro 245 250 INFORMATION FOR SEQ ID NO:543: SEQUENCE CHARACTERISTICS: LENGTH: 185 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...185 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:543 Val Val Phe Lys Ile Leu Ser Leu Trp Leu Gly Val Phe Cys Phe Leu 1 5 10 Arg Ala Thr His Leu Tyr Leu Gly GIu Glu Pro Lys Tyr Lys Asp Asn 25 Phe Thr His Phe Glu Tyr Ala Asn Pro Asn Ala Arg Lys Gly Gly Val 40 R Leu Arg Asn Asp Ala Ile Gly Thr Phe Asp Ser Leu Asn Pro Phe Ala L 50 55 Leu Lys Gly Thr Lys Ala Glu Gly Leu Asp Leu Ile Tyr Asp Thr Leu PCI/US 96/0 912 ir U o D 0EC 1996 451 70 75 Met Val Gln Ser Leu Asp Glu Pro Phe Ala Glu Tyr Pro Leu Ile Ala 90 Lys Asp Ala Glu Val Ala Lys Asp Asn Ser Tyr Val Ile Phe Thr Leu 100 105 110 Asp Lys Arg Ala Arg Phe Ser Asn Asn Ala Pro Ile Leu Ala Ser Asp 115 120 125 Val Lys Phe Ser Phe Asp Thr Ile Met Lys Leu Gly Ser Pro Leu Tyr 130 135 140 Arg Gin Tyr Tyr Gln Asp Val Lys Lys Ala Val Ile Leu Asp Lys His 145 150 155 160 His Val Lys Phe Ile Tyr Lys Thr Thr Glu Asn Lys Glu Leu Pro Leu 165 170 175 Ile Leu Gly Gin Leu Gin Ile Phe Ser 180 185 INFORMATION FOR SEQ ID NO:544: SEQUENCE
CHARACTERISTICS:
LENGTH: 37 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...37 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:544 Val Ala Met Ile Asp Cys Ala Ile Ile Gly Gly Gly Pro Ala Gly Leu 1 5 10 Ser Ala Gly Leu Tyr Ala Thr Arg Gly Gly Val Lys Asn Ala Val Leu 25 Phe Glu Lys Gly Met INFORMATION FOR SEQ ID NO:545: SEQUENCE CHARACTERISTICS: LENGTH: 93 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...93 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:545 Leu 1 Leu Phe His Tyr Unk Tyr Glu lie Gly Phe Phe Pro. Pro Asn Leu Glu Val -Asn Ser Tyr Lys Lys Unk Ser Ile Lys Leu Gly 70 Gly Val Thr Arg Tyr 55 Leu Leu 452 Gly Vi Thr I Asp T: Arg G 6 Ile G 75 Asn G Leu Thr Lys Val Leu PCT/US 9 6 0 1 |r.je.u6 L ib L996 ;er Phe 5 To Pro ,hr Gly Lsp Val ;er Lys INFORMATION FOR SEQ ID NO:545: SEQUENCE CHARACTERISTICS: LENGTH: 93 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...93 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:545 Leu Tyr Pro Pro Gly Ser Val Val Lys Met Gly Val 1 5 10 Leu Glu Asn Leu His Ile Thr Glu Asn Thr Thr Ile 25 Phe Ile Glu Val Gly Lys Arg Lys Phe Arg Asp Trp 40 His Gly Asn Ser Asn Leu Tyr Lys Ala Ile Arg Glu 55 Tyr Phe Tyr Lys Phe Gly Leu Glu Ile Ser Ile Glu 70 75 Unk Phe Lys Unk Ser Gly Leu Trp Gly Lys Asn Gly INFORMATION FOR SEQ ID NO:546: SEQUENCE CHARACTERISTICS: LENGTH: 182 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...182 Gly Leu Ser Phe Pro Thr Pro Pro Lys Lys Thr Gly Ser Val Asp Val Unk Leu Ser Lys Arg It/'US 18 DEC1996 453 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:546 Val Gly Lys Ser Leu Arg Tyr Ser Leu Asn Leu Asp Leu Asn Gln Lys 1 5 10 Ala Asp Leu Phe Phe Thr Glu Leu Glu Pro Thr Gly Leu Thr Leu Ser 25 Pro Ile Met Lys Arg Phe Thr Ile Lys Gly Asp Phe Asp Ser Gly Leu 40 Lys Ser Tyr Asp Met Ser Tyr Met Tyr Ala Ser Leu Gln Ala Ile Ser 55 Ala Ile Arg Arg Leu Pro Leu Gly Leu Tyr Asp Gly Val His Val Tyr 70 75 Ser Lys Thr Pro Met Lys Asp Ile Glu Lys Leu Arg Asn Ala Leu Lys 90 Thr Ile Asn His His Gly Ile Gly Ile Glu Gly Trp Trp Gln Gln Asn 100 105 110 Gly Asn Phe Phe Ser .Ala Met Glu Leu Glu Lys Arg Ala Leu Phe Ile 115 120 125 Val Leu Met Leu Ile Ile Leu Met Ala Ser Leu Asn Ile Ile Ser Ser 130 135 140 Leu Leu Met Val Val Met Asn Arg Arg Lys Glu Ile Ala Leu Leu Phe 145 150 155 160 Ser Met Gly Ser Ser Gln Lys Glu Ile Gln Lys Thr Phe Phe Tyr Leu 165 170 175 Gly Asn Ile Ile Ser Leu 180 INFORMATION FOR SEQ ID NO:547: SEQUENCE CHARACTERISTICS: LENGTH: 247 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...247 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:547 Met Lys Lys Thr Phe Leu Ile Ala Leu Ala Leu Thr Ala Ser Leu Ile 1 5 10 Gly Ala Glu Asn Thr Lys Trp Asp Tyr Lys Asn Lys Glu Asn Gly Pro 25 His Arg Trp Asp Lys Leu His Lys Asp Phe Glu Val Cys Lys Ser Gly 40 Lys Ser Gln Ser Pro Ile Asn Ile Glu His Tyr Tyr His Thr Gln Asp 55 Lys Ala Asp Leu Gln Phe Lys Tyr Ala Ala Ser Lys Pro Lys Ala Val 70 75 Phe Phe Thr His His Thr Leu Lys Ala Ser Phe Glu Pro Thr Asn His 90 Ile Asn Tyr Arg Gly His Asp Tyr Val Leu Asp Asn Val His Phe His 100 105 110 Ala Pro Met Glu Phe Leu Ile Asn Asn Lys Thr Arg Pro Leu Ser Ala 115 120 125 i.4U P 9 His Gly 145 G iy Leu Pro Giu Ser 225 Lys Val- His Giu Giu Gin Lys Lys Ser 180 Cys Thr 195 Ser Ala Asn Gin Ser Ala Lys Gly Lys 165 Ile Giu Lys Arg Giu 245 Gly Pro Lys His 185 Trp Giu Pro Arg Asn G iu 170 Phe Phe Ile Asp 454 Leu Li Leu A.
155 Vai A: Asn G'.
Val I: Lys L, 2: Tyr A., 235 Ile Giu 160 Phe Ala Leu Asn Ile 240 INFORMATION FOR SEQ ID NO:548: SEQUENCE CHARACTERISTICS: LENGTH: 422 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .422 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:S48 Met Lys Ilie Ser Leu Leu Gly His Gly 1 Arg Phe Lys Ile Glu Met Leu Gly Leu 145 Leu Cys Met Phe Pro Asp Ser le Thr Thr 130 Giu Ile Asn Pro Phe Ala .Phe Phe Asp Ser Thr 115 Pro Thr Tyr Phe Lys 195 Lys Phe Asn Thr Tyr Ile 100 Leu Leu Ser Leu Giu 180 Thr 5 Lys Phe Pro His Ile Ser Leu Ile Ser Leu 165 Asn Ser Asn Lys Asn Pro 70 Asp Gly Giu G iu Phe 150 Ile Tyr Leu His Asp Asp 55 Leu Sen Thr Asp Leu 135 Ser Asn Leu Ala Asn Ser 40 Ser Val1 Leu Asn Phe 120 Phe Leu Val1 Asn Ile Giu 25 Giu Gin Met Phe Gly 105 Lys G iu His Giu Ala 185 Leu Lys Val1 Gly Leu Lys Asp 90 Lys Ala Lys Tyr Ala 170 Lys Pro Lys Phe Giu Ala 75 His Thr Val Arg Thr 155 Asp Leu Leu Phe Leu Ile Lys Ser Thr Sen Ser 140 Asn His Lys Lys Phe Cys Val1 His Phe Thr Gly 125 Pro Lys Leu Val1 Phe Thr Thr Leu Ala Asp Tyr Ser Leu Thr Thr 110 G ly Leu Ala Thn Leu 190 Lys Leu Asp Pro Pro Met Pro Giu Asn Trp Tyr Trp 175 Thr Glu Gly Ljys Ser Gly Ser Thr Met Ile Val Pro 160 His Leu His 205 Pro Ile Val Gin Asn Ser Gin Ala Gin Lys Ile Phe Phe Asp Lys Ser iAMENCEL :Q'T IPEA/US 455 210 215 220 Glu Glu Val-Leu Glu Cys Leu Lys Ile Pro Ser Asn Ala Leu Phe Phe 225 230 235 240 Lys Gly Ala Phe Leu Leu Asp Ala Ala Leu Ala Leu Leu Val Tyr Glu 245 250 255 Gln Phe Leu Lys Ile Lys Asn Leu Lys Trp Gin Asp Tyr Arg Glu Asn 260 265 270 Ala Leu Lys Arg Leu Asn Ala Phe Lys Ile Gly Ser His Lys Met Glu 275 280 285 Glu Phe Arg Asp Lys Gin Gly Arg Leu Trp Val Asp Asp Ser Lys Ala 290 295 300 Thr Asn Ile Asp Ala Thr Leu Gin Ala Leu Lys Thr Phe Lys Asn Gin 305 310 315 320 Lys Ile His Leu Ile Leu Gly Gly Asp Ile Lys Gly Val Asn Leu Thr 325 330 335 Pro Leu Phe Glu Glu Phe Lys Asn Tyr Lys Ile Ser Leu Tyr Ala Ile 340 345 350 Gly Ser Ser Ala Ser Ile Ile Gin Ala Leu Ala Leu Glu Phe Asn Val 355 360 365 Ser Cys Gin Val Cys Leu Lys Leu Glu Lys Ala Val Gin Glu Ile Lys 370 375 380 Ser Val Leu Leu Gin Asn Glu Val Ala Leu Leu Ser Pro Ser Ala Ala 385 390 395 400 Ser Leu Asp Gin Phe Ser Ser Tyr Lys Glu Arg Gly Glu Lys Phe Lys 405 410 415 Ala Phe Val Leu Lys Asp 420 INFORMATION FOR SEQ ID NO:549: SEQUENCE CHARACTERISTICS: LENGTH: 60 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...60 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:549 Met Ala His His Unk Glu Gln His Gly Gly His His His His His His 1 5 10 His Thr His His His His Tyr His Gly Gly Glu His His His His His 25 His Ser Ser His His Glu Glu Gly Cys Cys Ser Thr Ser Asp Ser His 40 His Gin Glu Glu Gly Cys Cys His Gly Unk His Glu 55 INFORMATION FOR SEQ ID NO:549: SEQUENCE CHARACTERISTICS: LENGTH: 60 amino acids TYPE: amino acid TOPOLOGY: linear N Q'AIfl fl F< /Z 456 (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...60 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:549 Met Ala His His Unk Glu Gin His Gly Gly His His His His His His 1 5 10 His Thr His His His His Tyr His Gly Gly Glu His His His His His 25 His Ser Ser His His Glu Glu Gly Cys Cys Ser Thr Ser Asp Ser His 40 His Gin Glu Glu Gly Cys Cys His Gly Unk His Glu 55 INFORMATION FOR SEQ ID NO:550: SEQUENCE CHARACTERISTICS: LENGTH: 54 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...54 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:550 Met Lys Glu Ile Ile Val Ala Leu Val Gly Gin Pro Asn Val Gly Lys 1 5 10 Ser Ser Leu Ile Asn Ala Leu Ser Asn Thr His Leu Lys Val Gly Asn 25 Phe Thr Glu Val Thr Val Asp Lys Met Glu Val Ser Leu Ile Gin Lys 40 Asp His Gin Ile Asn Ser INFORMATION FOR SEQ ID NO:551: SEQUENCE CHARACTERISTICS: LENGTH: 297 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES PET/US 9 6/1 IPEAIUS ut J3 457 (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .297 (xi) SEQUENCE DESCRIPTION: SEQ ID rpn Val Lys Ile Arg Leu Phe Asp Phe Thr Ile Arg 1 Glu Giu Ser Ser Ile Tyr Lys Ala Gin 145 G ly Tyr Gin Ser Ile 225 Lys Phe Leu Asp Phe His Trp Met Thr Ile Phe Sen Sen Gin Ala Giu Ala Met 115 Leu Leu 130 Giu Val Vai1 Phe Arg Pro Lys Ilie 195 Sen Leu 210 Leu Asn Lys Tyr Lys Thr Lys Giu 275 Unk Unk 290 Ile Gin Ala Leu G iu Sen 100 His Ang Ala Asp Lys 180 Sen Ser Pro Tyr Arg 260 Leu C ly 5 Phe Asn Phe Asp Giu Ilie Leu As n Lys Giu 165 His Aia Leu Asn Glu 245 Sen Giu Glu Asp His Ile Ser 70 Leu Pro Giu Phe Giu i50 Glu Phe Leu Trp Asp 230 Asn Leu Glu Ile Phe Arg Ala 55 Asp Ala Asp Lys Ala 135 Ile Leu Glu Phe Ala 21.5 Val1 His Tyr Tyr Thr 295 Leu Lys 40 Ala Sen Gin Phe Ser 1.20 Leu Arg Tyr Giu Pro 200 Lys Lys Arg Phe Tyr 280 Gly Lys 25 Tyr Gly Ala Giu Lys 105 Ala Asp Lys Lys Sen 185 Lys Leu Ile Lys Asp 265 His Phe 10 Gly Leu Met Ala Tyr 90 Giu Leu Leu Thr Asn 170 Val1 Thn Gin Ser Asp 250 Ala Lys Ile Val1 Ile Lys 75 Ang Leu Asp Gly Asn 155 Ile Giu Thr Asp Leu 235 Phe Ser Asn Arg Val1 Gly Val1 Arg Thr Ser Leu 140 Val1 Leu Arg Thr Lys 220 Asn Lys Leu Lys Leu Val1 Thn Trp Gly Leu Glu Leu 125 Gly Phe Lys Leu Pro 205 Leu Giu Lys Giu Val1 285 Phe Leu Ile Gly Gin Lys Asp 110 Ile Ala Gin Gin Leu 190 Leu Asp Giu Pro Lys 270 Sen Lys Met Trp Gin Ile Asp Gin Asn Thr Lys Ser 175 Ile Giu Ile Giu Thr 255 Thn Tyr Pro Ile Ile Tyr Lys Ala Ile Gin Lys Asp 160 His Leu Gin Leu Met 240 Sen Asp Leu INFORMATION FOR SEQ ID NO:551: SEQUENCE CHARACTERISTICS: LENGTH: 297 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacten pyloni (ix) FEATURE: NAME/KEY: misc-feature NkokOED Sht:k ?GTiUS 96 09 i C I PEAWU o uE G 199 6 458 LOCATION .297 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:5S1 1Leu Val Lys Ile Arg Leu Phe Asp Phe Thr Ile Arg Giu Giu Ser Ser Ile T~yr Lys Ala Gin 145 Gly Tyr Gin Se r Ile 225 Lys Phe Leu Asp Phe -His Trp Met Thr Ile Phe Ser Ser Gin Ala Giu Aia Met 115 Leu Leu 130 Glu Val Val Phe Arg Pro Lys Ile 195 Ser Leu 210 Leu Asn Lys Tyr Lys Thr Lys Giu 275 Unk Unk 290 Ile Gin Ala Leu Glu Ser 100 His Arg Ala Asp Lys 180 Ser Ser Pro Arg 260 Leu Gly Phe Asn Phe Asp Giu Ilie Leu Asn Lys Giu 165 His Ala Leu As n Giu 245 Ser G lu Glu Leu Lys 40 Ala Ser Gin Phe Ser 120 Leu Arg Tyr Giu Pro 200 Lys Lys Arg Phe Tyr 280 Gly Lys 25 Tyr Gly Ala Giu Lys 105 Ala Asp Lys Lys Ser 185 Lys Leu Ile Lys Asp 265 His Phe Gly Leu Met Ala Tyr 90 Giu Leu Leu Thr As n 170 Val1 Thr Gin Ser Asp 250 Ala Lys Leu Val1 Thr Trp Giy Leu Giu Leu 125 Gly Phe Lys Leu Pro 205 Leu Giu Lys Giu Val1 285 Phe Leu Ile Gly Gin Lys Asp 110 Ile Ala Gin Gin Leu 190 Leu Asp Glu Pro Lys 270 Ser Lys Met Trp Gin Ile Asp Gin Asn Thr Lys Ser 175 Ile Giu Ile Glu Thr 255 Thr Tyr Pro Ile Ile Tyr Lys Ala Ile Gin Lys Asp 160 His Leu Gin Leu Met 240 Ser Asp Leu INFORMATION FOR SEQ ID NO:552: SEQUENCE CHARACTERISTICS: LENGTH: 90 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc-feature LOCATION (xi) SEQUENCE DESCRIPTION: SEQ ID NO:552 Met Val Lys His Tyr Leu Phe Met Ala Val Ser Gin Val Phe Phe Ser ACIunlnfl Qw4p POT/US 96/ 9 1Z IPEAU6 i 8 uE C 1996 459 1 5 10 Phe Phe Leu Val Leu Phe Phe Ile Ser Ser Ile Val Leu Leu Ile Ser 25 Ile Ala Ser Val Thr Leu Val Ile Lys Val Ser Phe Leu Asp Leu Val 40 Gin Leu Phe Leu Tyr Ser Leu Pro Gly Thr Ile Phe Phe Ile Leu Pro 55 Ile Thr Phe Phe Ala Ala Unk Arg Leu Gly Unk Ser Arg Leu Ser Tyr 70 75 Asp His Glu Leu Leu Val Phe Phe Leu Unk INFORMATION FOR SEQ ID NO:552: SEQUENCE CHARACTERISTICS: LENGTH: 90 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...90 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:552 Met Val Lys His Tyr Leu Phe Met Ala Val Ser Gln Val Phe Phe Ser 1 5 10 Phe Phe Leu Val Leu Phe Phe Ile Ser Ser Ile Val Leu Leu Ile Ser 25 Ile Ala Ser Val Thr Leu Val Ile Lys Val Ser Phe Leu Asp Leu Val 40 Gin Leu Phe Leu Tyr Ser Leu Pro Gly Thr Ile Phe Phe Ile Leu Pro 55 Ile Thr Phe Phe Ala Ala Unk Arg Leu Gly Unk Ser Arg Leu Ser Tyr 70 75 Asp His Glu Leu Leu Val Phe Phe Leu Unk INFORMATION FOR SEQ ID NO:553: SEQUENCE CHARACTERISTICS: LENGTH: 111 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...111 POT/US 96/09122 IPEA/US 18 DEC 1996 460 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:553 Val His Arg Phe Ser Arg Asn Pro Cys Ala Ser Cys Asn Arg Ala Arg 1 5 10 Ser Cys Ser Arg Leu Ser Arg Ser Leu Val Ser Ala Val Thr Trp Trp 25 Leu Ser Leu Ser Phe Ser Val Val Ser Ala Leu Phe Ser Leu Val Ser 40 Ser Val Ile Leu Trp Val Ser Ser Val Phe Ser Leu Phe Ser Leu Ser 55 Phe Ser Val Val Asn Ser Leu Phe Ser Ser Val Ser Arg Ser Leu Ala 7.0 75 Ala Asn Lys Arg Val Phe Ser Leu Ala Lys Met Ser Phe Ser Val Phe 90 Ser Ser Ala Phe Ser Leu Val Ser Leu Leu Leu Phe Cys His Asn 100 105 110 INFORMATION FOR SEQ ID NO:554: SEQUENCE CHARACTERISTICS: LENGTH: 137 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...137 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:554 Met Gin Lys Met Gly Val Val Ser Tyr Ser Val Phe Gin Ala Phe Glu 1 5 10 Lys Ala Leu Ser Arg Phe Lys Glu Gly Val Val Leu Ile Val Asp Ser 25 Leu Arg Arg Leu Ile Met Gly Ser Ala Ser Val Lys Glu Leu Ser Gly 40 Val Ile Gly Ile Val Gly Ala Leu Ser His Ala Asn Ser Val Ser Met 55 Leu Leu Leu Phe Gly Ala Phe Leu Ser Ile Asn Leu Gly Ile Leu Asn 70 75 Leu Leu Pro Ile Pro Ala Leu Asp Gly Ala Gin Met Leu Gly Val Val 90 Phe Lys Asn Ile Phe His lie Ala Leu Pro Thr Pro Ile Gin Asn Ala 100 105 110 Leu Trp Leu Val Gly Val Gly Phe Leu Val Phe Val Met Phe Leu Gly 115 120 125 Leu Phe Asn Asp Ile Thr Arg Leu Leu 130 135 INFORMATION FOR SEQ ID NO:555: SEQUENCE CHARACTERISTICS: LENGTH: 124 amino acids TYPE: amino acid TOPOLOGY: linear SAtintr OLUCCTIl i- o 461 (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...124 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:555 Val Met Ala Leu Leu Lys Ile Ser Val Val Val Pro Glu Gly Glu Val 1 5 10 Tyr Thr Gly Glu Val Lys Ser Val Val Leu Pro Gly Val Glu Gly Glu 25 Phe Gly Val Leu Tyr Gly His Ser Asn Met Ile Thr Leu Leu Gln Ala 40 Gly Val Val Glu Ile Glu Thr Glu Asn Gln Lys Glu His Ile Ala Ile 55 Asn Trp Gly Tyr Ala Glu Val Thr Asn Glu Arg Val Asp Ile Leu Ala 70 75 Asp Gly Ala Val Phe Ile Lys Lys Gly Ser Asp Asp Arg Asp Asp Ala 90 Ile Ser Arg Ala Lys Lys Leu Leu Glu Asp Ala Ser Ser Asp Arg Leu 100 105 110 Ala Val Ser Ser Val Leu Ala Lys Ile Glu Ser Leu 115 120 INFORMATION FOR SEQ ID NO:556: SEQUENCE CHARACTERISTICS: LENGTH: 86 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...86 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:556 Met Tyr Ser Leu Leu Leu Asp Leu Asn Lys Lys Thr Ala Leu Leu Gly 1 5 10 Thr Arg Gly Phe Phe Ile Asp Asp Lys His Ile Lys Glu Lys Gly Leu 25 Thr Thr Pro Thr Leu Leu Glu Leu Tyr Ser Asp Leu Glu Glu Ala Ile 40 Arg Leu Lys Cys Glu Tyr Phe Ile Met Glu Val Ser Ser His Ala Ile 55 Val Gln Asn Ala Ser Leu Gly Leu Ile Ser Leu Leu Lys Phe Ser Pro 70 75 Ile Ser Gln Ala Ile Ile V,7'770 SHEET 462 INFORMATION FOR SEQ ID NO:557: SEQUENCE
CHARACTERISTICS:
LENGTH: 86 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...86 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:557 Met Ser Lys Arg Ala Ile Arg Phe Pro Asn Lys Leu Phe Ser Tyr Pro 1 5 10 is Lys Pro Lys Ile Lys Ala Thr Asn Thr Ser His Thr Val Leu Phe Ala 25 Tyr Pro Leu Lys Pro His Glu Met Ala Leu Leu Ala Leu Ala Thr Ser 40 Leu Leu Ala Pro Ile Phe Asn Ala Ile His Ser Thr Asn Ala Leu Asn 55 Ala Ile Lys Pro Asp Gly Thr Gly Ser Lys Ile Asn Pro Ile Ile Met 70 75 Pro Met Lys Ile Gln Lys INFORMATION FOR SEQ ID NO:557: SEQUENCE
CHARACTERISTICS:
LENGTH: 86 amino acids.
TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_ feature LOCATION 1...86 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:557 Met Ser Lys Arg Ala Ile Arg Phe Pro Asn Lys Leu Phe Ser Tyr Pro 1 5 10 Lys Pro Lys Ile Lys Ala Thr Asn Thr Ser His Thr Val Leu Phe Ala 25 Tyr Pro Leu Lys Pro His Glu Met Ala Leu Leu Ala Leu Ala Thr Ser 40 Leu Leu Ala Pro Ile Phe Asn Ala Ile His Ser Thr Asn Ala Leu Asn 55 Ala Ile Lys Pro Asp Gly Thr Gly Ser Lys Ile Asn Pro Ile Ile Met P o 70
S
Pro Met Lys Ile Gin Lys :D SHFFT IPEA/US 8 DEC i996 463 INFORMATION FOR SEQ ID NO:558: SEQUENCE CHARACTERISTICS: LENGTH: 108 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...108 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:558 Met Lys Thr Asn Phe Tyr Lys Ile Lys Leu Leu Phe Ala Trp Cys Leu 1 5 10 Ile Ile Gly Met Phe Asn Ala Pro Leu Asn Ala Asp Gin Asn Thr Asp 25 Ile Lys Asp Ile Ser Pro Glu Asp Met Ala Leu Asn Ser Val Gly Leu 40 Val Ser Arg Asp Gin Leu Lys Ile Glu Ile Pro Lys Glu Thr Leu Glu 55 Gin Lys Val Thr Ile Leu Asn Asp Tyr Asn Asp Lys Asn Val Asn Ile 70 75 Lys Phe Asp Asp Ile Ser Leu Gly Ser Phe Gin Pro Asn Asp Asn Leu 90 Gly Ile Asn Ala Met Trp Gly Ile Gin Asn Leu Leu 100 105 INFORMATION FOR SEQ ID NO:559: SEQUENCE CHARACTERISTICS: LENGTH: 141 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...141 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:559 Val Tyr Ser Arg Phe Phe Ala Asn Gln His Glu Phe Asp Phe Glu Ala 1 5 10 Gin Gly Ala Leu Gly Ser Asp Gin Ser Ser Leu Asn Phe Lys Ser Thr LeL-u. 20 25 Leu Leu Gin Asp Leu Asn Gin Ser Tyr Asn Tyr Leu Ala Tyr Ser Ala 35 40 4- 0 U C CT IPLNUS 0 LEU G'3-6 Thr Leu Thr Ala Ile Lys Ala Val Asn Ser Ile Ser 130 Arg Leu Phe Ser Met 115 Ser Gly 55 Val Ser Phe His Asp 135 Tyr Gly Gin Asn Thr 120 Arg Asp Val Ser Ala 105 Phe Met 464 Ala Phe Tyr Asn Val Ala Ala Thr Cys Met Trp Arg 140 Phe Arg His Leu Leu Lys Trp Lys 110 Trp Glu 125 Leu INFORMATION FOR SEQ ID NO:559: SEQUENCE CHARACTERISTICS: LENGTH: 141 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...141 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:559 Val Tyr Ser Arg Phe Phe Ala Asn Gln His Glu Phe Asp Phe Glu Ala 1 Gin Leu Thr Leu Thr Ala Ile Lys Gly Leu Ala Val Asn Ser Ile Ser 130 Ala Gin Arg Leu Phe Ser Met 115 Ser Leu Asp Ala Lys Lys Gin 100 Gly Leu 5 Gly Leu Ser Pro Ser His Thr Thr Gin Ser 40 Tyr Gly Gin Asn Thr 120 Arg Ser 25 Tyr Asp Val Ser Ala 105 Phe Met 10 Ser Asn Phe Ser Gin 90 Asn Ile Met Asn Leu Phe Asn Ala Thr Met Arg 140 Phe Ala Phe His Leu Trp Trp 125 Leu Lys Tyr Arg Leu Lys Lys 110 Glu Ser Ser Asn Gly Asn Arg Phe INFORMATION FOR SEQ ID NO:560:- SEQUENCE CHARACTERISTICS: LENGTH: 231 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES 4 PCT/US 9 6/0912 465 iFPEA/US i 8 DEC 1996 (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...231 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:560 Met Ile Asp Asn Leu Asp Gly Ala Lys Asp Ala Gln Leu Ile Lys Lys 1 5 10 Ala Tyr Ala Phe Leu Cys Leu Gly Gly Asp Gly Thr Ile Leu Gly Ala 25 Leu Arg Met Thr His Ala His Asn Lys Pro Cys Phe Gly Val Arg Ile 40 Gly Asn Leu Gly Phe Leu Ser Ala Val Glu Leu Asn Gly Leu Lys Asp 55 Phe Leu Gin Asp Leu Lys Gin Asn Arg Ile Lys Leu Glu Glu His Leu 70 75 Ala Leu Glu Gly Arg Ile Gly Asn Thr Ser Phe Tyr Ala Ile Asn Glu 90 Ile Val Ile Ala Lys Lys Lys Ala Leu Gly Val Leu Asp Ile Lys Ala 100 105 110 Cys Ala Gly His Thr Pro Phe Asn Thr Tyr Lys Gly Asp Gly Leu Ile 115 120 125 Ile Ala Thr Pro Leu Gly Ser Thr Ala Tyr Asn Leu Ser Ala His Gly 130 135 140 Pro Ile Val His Ala Leu Ser Gin Ser Tyr Ile Leu Thr Pro Leu Cys 145 150 155 160 Asp Phe Ser Leu Thr Gin Arg Pro Leu Val Leu Gly Ala Glu Phe Cys 165 170 175 Leu Ser Phe Cys Ala His Glu Asp Ala Leu Val Val Ile Asp Gly Gin 180 185 190 Ala Thr Tyr Asp Leu Lys Ala Asn Gin Pro Leu Tyr Ile Gin Lys Ser 195 200 205 Pro Thr Thr Thr Lys Leu Leu Gin Lys Asn Ser Arg Asp Tyr Phe Lys 210 215 220 Val Leu Lys Glu Lys Leu Leu 225 230 INFORMATION FOR SEQ ID NO:561: SEQUENCE CHARACTERISTICS: LENGTH: 185 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...185 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:561 Met Unk Glu Asn Gly Arg Gly Val Pro Lys Asp Tyr Lys Lys Ala Val 1 5 10 Glu Tyr Phe Gln Lys Ala Val Asp Asn Asp Ile Pro Arg Gly Tyr Asn 25 ACT/US 6/9£ c IPENIUS 1 8 DEC 19-96 As n Lys As n Pro Lys Gly Tyr Ser 145 Ala Cys Gly.Val Ala Val Tyr Ile Asn Tyr Asn Val 100 Ile Asn 115 Met Ala Ser Tyr Glu Tyr Lys Lys 180 Lys Phe Gly Ala Tyr Leu Val1 135 Gly Lys Ser Glu 40 Arg Ile Thr Ile Ser 120 Ser Leu Ala Ser Gly Ile Met Glu Leu 105 Arg Ser Gly Cys Arg 185 466 Gly Val Thr Glu Met Glu Phe Arg Gly Asp Lys Ile Arg Ala 140 Glu Lys 155 Phe Asp Pro Lys Gly Lys Ile Arg 125 Tyr Unk Ile Lys Gly Arg Ala Tyr 110 Leu Unk Unk Asp Asp Tyr Gly Met Tyr Val1 Gly Lys Lys 175 INFORMATION FOR SEQ ID NO:561: SEQUENCE CHARACTERISTICS: LENGTH: 185 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 185 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:561 Met Unk Glu Asn Gly Arg Gly Val Pro Lys Asp Tyr Lys Lys 1 Giu Asn Lys Asn Pro Lys Gly Tyr Ser 145 Ala Cys Tyr Leu Lys so Ala Sen Gly Met Lvs 130 Glu Giu Lys Phe Gly Ala Tyr Asn Asn Ile 115 Met Ser Giu Lys Gin Val1 Val1 Ile Tyr Val1 100 Asn Ala Tyr Tyr Lys 5 Lys Met Glu Asn Ala Unk Tnp Ala Unk Met 165 Asn Ala Tyr Leu 70 Lys Ala Val1 Asp Tyr 150 Gin Thr Val Asp Lys Glu 40 Phe Ang Gly Ile Ala Thr Tyn Ile Leu Sen i2 0 Val Ser 135 Gly Leu Lys Ala Sen Sen 10 Asn Asp 25 Gly Lys Ile Ala Met Tyn Glu Cys 90 Leu Leu 105 Ang Thr Ser Sen Gly Val Cys Asp 170 Arg Ile Gly Thr Met 75 Phe Gly Lys Arg Glu 155 Phe Pro Val1 Glu Giu Arg Asp Ile Ala 140 Lys Asp Arg Pro Lys Gly Lys Ile Arg 125 Tyr Unk Ile Gly Lys Gly Arg Ala 110 Leu Unk Unk Asp Ala Tyr Asp Tyr Gly Met Tyr Val1 G ly Lys Lys 175 Val1 Asn Glu Thn Val His Sen His Leu Lys 160 Asn 467 1%EC ,8 -180 185 INFORMATION FOR SEQ ID NO:562: SEQUENCE CHARACTERISTICS: LENGTH: 183 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .183 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:562 Met Ile Val Gly Leu Ile Gly Val Val Glu Lys Ile Ser Ala Leu Glu 1 5 10 Ala His Ile Glu Val Gln Gly Val Val Tyr Gly Val Gln Val Ser Met 25 Arg Thr Ala Ala Leu Leu Gln Thr Gly Gln Lys Ala Arg Leu Lys Ile 40 Leu Gln Val Ile Lys Glu Asp Ala His Leu Leu Tyr Gly Phe Leu Glu 55 Glu Ser Glu Lys Ile Leu Phe Glu Arg Leu Leu Lys Ile Asn Gly Val 70 75 Gly Gly Arg Ile Ala Leu Ala Ile Leu Ser Ser Phe Ser Pro Asn Glu 90 Phe Glu Asn Ile Ile Ala Thr Lys Glu Val Lys Arg Leu Gln Gln Val 100 105 110 Pro Gly Ile Gly Lys Lys Leu Ala Asp Lys Ile Met Val Asp Leu Ile 115 120 125 Gly Phe Phe Ile Gln Asp Glu Asn Arg Pro Ala Arg Asn Glu Val Phe 130 135 140 Leu Ala Leu Glu Ser Leu Gly Phe Lys Ser Ala Glu Ile Asn Pro Val 145 150 155 160 Leu Lys Thr Leu Lys Pro His Leu Ser Ile Glu Ala Ala Ile Lys Glu 165 170 175 Ala Leu Gln Gln Leu Arg Ser 180 INFORMATION FOR SEQ ID NO:563: SEQUENCE CHARACTERISTICS: LENGTH: 154 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature PCT/US 9 6/U LOCATION 1...154 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:563 Val Gly Val Leu Leu Ala Leu Phe Phe Phe Tyr Ala Lys Asn Asn Leu 1 5 10 Leu Glu Asn Thr Gin Ile Arg Met Gin Tyr Thr Ala Asp Ala Ile Ala 25 Lys Ser Leu Leu Glu Leu Asn Asn Ala Ser Ser Leu Glu Pro Leu Lys 40 Ile Leu Glu Glu Arg Phe Lys Asn Thr Pro Phe Val Leu Leu Asp Ala 55 Asp Asn Arg Val Lys Phe Ser Asn Ile Gly Val Phe Val Ala Ser Phe 70 75 Lys Asn Asp Ala Leu Ile Lys Thr Pro Tyr Phe Ala Leu Lys Lys Gin 90 Gly Phe Tyr Leu Thr Asp Ser Ala Pro Thr Asn Arg Leu Gly Val Ser 100 105 110 Lys Ile Ile Ile Ala Glu Glu Glu Ile Gln Lys Ile Phe Ile Pro Leu 115 120 125 Tyr Lys Met Ile Gly Tyr Val Phe Leu Gly Ala Ser Leu Phe Val Ala 130 135 140 Leu Ile Ala Met Trp Leu Tyr Lys Ile Pro 145 150 INFORMATION FOR SEQ ID NO:564: SEQUENCE CHARACTERISTICS: LENGTH: 288 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...288 (xi).SEQUENCE DESCRIPTION: SEQ ID NO:564 Val Val Ile Met Ile Leu Val Cys Phe Leu Ala Cys Ser Gln Glu Ser 1 5 10 Phe Ile Lys Met Gin Lys Lys Ala Gln Glu Gin Glu Asn Asp Gly Ser 25 Lys Arg Pro Ser Tyr Val Asp Ser Asp Tyr Glu Val Phe Ser Glu Thr 40 Ile Phe Leu Gln Asn Met Val Tyr Gln Pro Ile Glu GIu Arg Asn Ala 55 Phe Phe Gln Leu Thr Lys Asp Glu Asp Asn Ser Phe Asn Pro Glu Asn 70 75 Ser Val Ile Leu Leu Asn Glu Pro Ser Asp Asn Ser Glu Lys Asn Leu 90 Leu Ser Tyr Pro Asn Asp Pro Asn Asn Asn Glu Asp Asn Ala Asn Asn 100 105 110 Ser Gln Lys Asn Pro Phe Leu Tyr Lys Pro Lys Arg Lys Thr Lys Asn 115 120 125 Pro Lys Leu Ile Glu Tyr Ser Gln Gln Asp Phe Tyr Pro Leu Lys Asn 130 135 140 Gly Asp Ile Ile Met Ser Lys Glu Gly Asp Gln Trp Leu Ile Glu Ile ft ?Wi~ yO/U1iLL 145 Gin Ser Lys Arg Gin Ile Gin leLys 195 Ser Leu Ser 210 Ser Asp Asn 225 Ile Ser Lys Asp Ser Gin Arg Phe Lys 275 Ala Gin 180 Gly Leu Val1 Cys His 260 Ser Leu 165 Thr Lys Arg Tyr Gin 245 Lys Asp Phe Phe Ser 200 Tyr Glu Leu Ser Leu 280 Leu As n 185 Tyr Glu As n Lys Ile 265 Phe Lys 170 Asp Val1 Ser Lys Lys 250 Asp Leu 155 Asp Thr 'y r Phe Ala 235 His Leu Glu Gin Lys Thr Leu 220 Leu Ser Asp Cys Asn Thr Thr 205 Leu Asp Thr Phe Leu 285 Asp Gin 190 Asn Glu Thr Asp Lys 270 Lys 160 Asp Ala Gly Lys Giu 240 Leu Giu Ser INFORMATION FOR SEQ ID NO:565: SEQUENCE CHARACTERISTICS: LENGTH: 420 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .420 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:565 Met Ala Ala Pro Leu Leu Ala Leu Pro Phe Let, Ser 1 Leu Lys Leu Glu Leu Phe Ser Gly Thr 145 Tyr Ser Ser Ala Asp Phe Leu Ile Ile Tyr 115 Ser Ala Thr Thr Asn 195 Leu Ser Phe Ala Leu Lys 100 His Ser As n As n As n 180 Lys
S
Ala Leu Ile Asn Leu Thr Tyr Phe Leu Ser 165 Ala Leu Val1 25 Ala Sen Pro Lys Leu 105 Ser As n G ly His Phe 185 Phe Gly Asp Lys Phe Arg 90 Phe Asp His Ile Lys 170 His Lys Ala Gly Ile Gly 75 Tyr Val1 Gly Val.
Sen As n Val1 I le Asn Leu Tyr Lys Val.
Asn Val Ser 125 Glu Val1 Asp Gin Asn 205 Pro Tyr Ser Gly Leu As n Gly 110 Ser Ile Val Thr Ile 190 Gly Leu Pro Giu Ile Gly Asp Tyr Gly Phe Lys His 175 Leu Leu Val.
Asn Ile Giy Met Leu Leu Asn Asp Glu 160 His Thr Ser A MFN r )R r-T 470 Leu Lys Thr-.Leu Ile Ala Ala Val Leu Leu Leu Val Ile Leu Gly Leu 210 215 220 Glu Leu Phe Leu Leu Phe Lys Val Phe Cys Tyr Val Phe Met Thr Tyr 225 230 235 240 Leu Glu Lys Ile Ile Tyr Leu Ser Leu Val Ile Phe Met Leu Leu Leu 245 250 255 Gly Phe Phe Gin Gin Thr Arg Gly Phe Leu Val Ser Tyr Val Lys Lys 260 265 270 Ile Ile Ser Leu Thr Phe Tyr Met Pro Leu Leu Leu Leu Leu Val Leu 275 280 285 Phe Asn Ser Phe Ala Leu Gln Tyr Ala Ile Lys Val Gly Gly Ser Asn 290 295 300 Glu Ile Val Ala Lys Phe Gly Ile Ile Val Ala Ile Gly Ile Ser Leu 305 310 315 320 Thr Phe Ile Gin Lys Val Pro Glu Met Ile Asn Ala Ile Phe Gly Thr 325 330 335 Gin Gly Gly Leu Thr Asp Ala Lys Ser Phe Ile Tyr Gin Gly Val Gin 340 345 350 Met Ala Ser Ala Gly Ala Gly Ala Ile Ala Gly Ser Leu Lys Ser Val 355 360 365 Gly Arg Ser Ala Phe Gly Arg Thr Leu Glu Ala Tyr Lys Asp Ala Lys 370 375 380 Ser Thr Ile Asn Ser Thr Thr Ala Asn Met Arg Asp Met Pro Gly His 385 390 395 400 Pro Gly Val Arg Val Gly Val Glu Thr Ile Glu Leu Pro Lys Ser His 405 410 415 Arg Ala Ser Lys 420 INFORMATION FOR SEQ ID NO:566: SEQUENCE CHARACTERISTICS: LENGTH: 72 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori
FEATURE:
NAME/KEY: misc_feature LOCATION 1...72 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:566 Val Leu Lys Phe Gin Lys Leu Pro Leu Leu Phe Val Ser Ile Leu Tyr 1 5 10 Asn Gin Ser Pro Leu Leu Ala Phe Asp Tyr Lys Phe Ser Gly Val Ala 25 Glu Ser Val Ser Lys Val Gly Phe Asn His Ser Lys Leu Asn Ser Lys 40 Glu Gly Ile Phe Pro Thr Ala Thr Phe Val Thr Ala Thr Ile Lys Leu 55 Gin Val Asn Tyr Lys Ser Ala Pro INFORMATION FOR SEQ ID NO:567: SEQUENCE CHARACTERISTICS:
F
IPEAUS 18 DE C1996 471 LENGTH: 205 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...205 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:567 Met Gly Asn His Phe Ser Lys Leu Gly Phe Val Leu Ala Ala Leu Gly 1 5 10 Ser Ala Ile Gly Leu Gly His Ile Trp Arg Phe Pro Tyr Met Thr Gly 25 Val Ser Gly Gly Gly Ala Phe Val Leu Leu Phe Leu Phe Leu Ser Leu 40 Ser Val Gly Ala Ala Met Phe Ile Ala Glu Met Leu Leu Gly Gln Ser 55 Thr Gln Lys Asn Val Thr Glu Ala Phe Lys Glu Leu Asp Ile Asn Pro 70 75 Lys Lys Arg Trp Lys Tyr Ala Gly Ile Met Leu Ile Ser Gly Pro Leu 90 Ile Leu Thr Phe Tyr Gly Thr Ile Leu Gly Trp Val Leu Tyr Tyr Leu 100 105 110 Val Ser Ile Ser Phe Asn Leu Pro Ser Ser Ile Gln Glu Ser Glu Gin 115 120 125 Ile Phe Thr Gln Thr Leu Gln Ser Ile Gly Leu Gln Ser Ile Gly Leu 130 135 140 Phe Ser Val Leu Phe Ile Thr Gly Trp Ile Val Ser Arg Gly Ile Lys 145 150 155 160 Glu Gly Ile Glu Lys Leu Asn Leu Val Leu Met Pro Leu Leu Phe Ala 165 170 175 Thr Phe Phe Gly Leu Leu Phe Tyr Ala Met Ser Met Asp Ser Phe Ser 180 185 190 Lys Ala Phe His Phe Met Leu Ile Ser Ser Gln Lys Ile 195 200 205 INFORMATION FOR SEQ ID NO:568: SEQUENCE CHARACTERISTICS: LENGTH: 328 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...328 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:568 AMW t'i) w1i I PCTUS 96/001127 IPENIJ S 18 D Uu -1906 Met Giu Lys--Val Cys Val Ser Ala Trp G lu Ala Ala Leu Leu Lys Ala Lys I le 145 Arg I le Ala Ser Ile 225 Leu Met Leu Ala Val1 305 Gin Arg Lys Lys Lys Phe Ile Leu Val 130 Val1 Gin Lys Phe Ile 210 Ala Phe Thr Asn I le 290 Lys Tyr Leu Ala Glu Lys Asp Gly Ilie 115 Pro Gin Leu Giu Giu 195 Tyr Leu His Phe Pro 275 Leu Ser Lys Lys Ile Gin Val1 Giu Asp 100 Giu Arg Val1 Gin 180 Val1 Thr Ile Lys Giu 260 Thr Lys Arg Asp Giu Asn Gin Gly Val1 Trp Ala Leu Ala Ala 165 Asn Trp As n Ser Giu 245 Phe G ly Asp Ile Val1 325 Lys Giu Lys Leu 70 Lys Ile Ile Val Asp 150 Ser Giu Asp Ile Lys 230 Lys Giu Phe Leu Ilie 310 Lys Ty'r Giu Thr 55 Lys Giu Phe Ile Thr 135 Lys Tyr Ile Phe As n 215 Thr Leu Pro Ile Asp 295 His G iu Gly Giu 40 Gin Lys Ala Ser Ile 120 Phe Ser Val1 Ala Phe 200 Leu Gin Giu Ile Val1 280 Giu Val1 Gin Asp 25 Leu Arg Arg Asp Ser 105 Val1 Ser Ile Asn His 185 Glu Thr Ala Ser Giu 265 Thr Lys Giu Gly 10 Asp G lu G lu Asp Val1 90 Ala Cys Asn Arg As n 170 G iu Lys Arg As n Glu 250 Ile Gly Asn Lys Leu Trp Giu Lys Met 75 Leu Val Leu Ala Ala 155 Arg Thr Leu Lys Ile 235 Lys Asp Tyr Lys Lys 315 Pro Giu Gin Thr Leu Phe Phe Leu Thr 140 Asn Giu Ile Val1 Ile 220 Giu Arg Thr Asp Val1 300 Asp Lys Lys Val1 Leu Gin Gin Phe Pro 125 Gin Gin Asn Arg Ser 205 Ser Ile Tyr Lys Val1 285 Lys Pro Ile His Lys As n Ser Ala Phe 110 Leu Asn Ala Ile Leu 190 Tyr Ile Ser Arg Ser 270 Thr Asp His Leu Val1 Ala Gly Thr Giu Ala Lys Phe Leu Ser 175 Gin Glu Ile Ala Ile 255 Val1 Glu Asp Met Glu Lys Lys Phe Met Arg Leu Giu Ala Val1 160 Ser Ser His Asn Gin 240 Ile Pro Ile Gly Ser 320 INFORMATION FOR SEQ ID NO:569: SEQUENCE CHARACTERISTICS: LENGTH: 139 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .139 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:569 Leu Leu Asn Met Trp Asp Glu Ala Lys Lys Giu Gly Ile Asn Ile Asn
IFEANS
1 Thr Ala Ile Val Gin Phe Trp Leu Glu Lys Arg Unk Val Arg Pro Ser Arg Ile Glu His Asp Phe 115 Phe Asn 130 Leu Leu Asn Glu Ile Asp Val 120 Ala Gly Asn Thr Ser Ser Lys 105 Tyr Lys INFORMATION FOR SEQ ID NO:569: SEQUENCE CHARACTERISTICS: LENGTH: 139 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...139 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:569 Leu Leu Asn Met Trp Asp Glu Ala Lys 1 Thr Glu Ala Arg Ile Val Val Pro Gin Arg Phe Glu Trp Asp Leu Phe 130 Lys Unk Arg Ser Ile His Phe 115 Asn Leu Lys Leu Gin Ala Thr 100 His Arg 5 Ser Glu Tyr Ser Lys Tyr Phe Arg Gin Asp Ser Phe 70 Ser Lys Phe Gly Glu Arg Gin Lys Val Ile Unk Ser 135 Leu Leu 40 Asn Glu Ile Asp Val 120 Ala Gly 25 Asn Thr Ser Ser Lys 105 Tyr Lys Lys 10 Val Thr Thr Leu Glu 90 Ile Val Ser Glu Gly Ile Asn Val Glu Asn Lys 75 Asn Phe Tyr Pro Val Leu Glu Ser Gin Ala Leu 125 Pro Leu Asn Gin Asn Pro 110 Phe Ile Thr Asp Ile Ser Ala Ala Phe Asn Ser Glu Lys Ala Ser Leu Glu INFORMATION FOR SEQ ID NO:570: SEQUENCE CHARACTERISTICS: LENGTH: 76 amino acids TYPE: amino acid TOPOLOGY: linear II N AMENDED SHEET IPEANUS 18 DEC1996 474 (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...76 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:570 Met Leu His Lys Ala Lys Val Gly Ile Val Phe Gln Ala Leu Leu Gly 1 5 10 Ile Phe Cys Val Phe Leu Leu Leu Phe Tyr Leu Ser Ala Phe Leu Met 25 Val Ala Phe Lys Asp Thr Lys Arg Met Phe Ile Ser Val Leu Ile Gly 40 Ser Val Val Phe Leu Trp Ser Asp Leu Leu Val Phe Val Gly Phe Lys 55 Asn Ile Ser Phe Val Leu Asp Ile Gly Tyr Glu Ile 70 INFORMATION FOR SEQ ID NO:571: SEQUENCE CHARACTERISTICS: LENGTH: 193 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicebacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...193 (xi).SEQUENCE DESCRIPTION: SEQ ID NO:571 Met Gln Giu Ala Leu Leu Arg Phe Gln Glu Gly Phe Lys Glu Trp Gly 1 5 10 Tyr Leu Ile Leu Phe Leu Tyr Ser Leu Gly Gly Gly Tyr Val Gly Ile 25 Val Ile Ala Ser Ile Leu Ser Ala Thr Thr His Ala Leu Asp Ile Lys 40 Ile Thr Ile Leu Val Ala Phe Leu Gly Asn Leu Ile Gly Ser Gly Ala 55 Leu Val Ile Phe Ala Arg Tyr Gln Lys Arg Glu Phe Leu Lys Tyr Phe 70 75 Gin Lys His Arg Arg Lys Leu Ala Leu Ala Ser Leu Trp Val Lys Arg 90 Tyr Ala Leu Leu Met Ile Phe Val Asn Lys Tyr Leu Tyr Gly Ile Lys 100 105 110 Ser Val Val Pro Leu Ala Ile Gly Phe Ser Lys Tyr Pro Leu Lys Lys 115 120 125 Phe Leu Trp Leu Asn Val Phe Ser Ser Phe Leu Trp Ala Leu Ile Val Az G 130 135 140 'T Gly Ser Val Ser Phe Gln Ala Ser Asp Trp Val Lys Thr Leu Tyr Glu
LU
?F IPENUS i ubU 96 475 145 150 155 160 Arg Leu Ser His Tyr Thr Ser Phe Phe Val Ile Ser Phe Val Leu Ile 165 170 175 Ala Leu Leu Ile Trp Phe Leu Leu Lys Arg Tyr Ser Arg Lys Met Gly 180 185 190 Phe INFORMATION FOR SEQ ID NO:571: SEQUENCE CHARACTERISTICS: LENGTH: 193 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...193 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:571 Met Gln Glu Ala Leu Leu Arg Phe Gln Glu Gly Phe Lys Glu Trp Gly 1 5 10 Tyr Leu Ile Leu Phe Leu Tyr Ser Leu Gly Gly Gly Tyr Val Gly Ile 25 Val Ile Ala Ser Ile Leu Ser Ala Thr Thr His Ala Leu Asp Ile Lys 40 Ile Thr Ile Leu Val Ala Phe Leu Gly Asn Leu Ile Gly Ser Gly Ala 55 Leu Val Ile Phe Ala Arg Tyr Gln Lys Arg Glu Phe Leu Lys Tyr Phe 70 75 Gin Lys His Arg Arg Lys Leu Ala Leu Ala Ser Leu Trp Val Lys Arg 90 Tyr Ala Leu Leu Met Ile Phe Val Asn Lys Tyr Leu Tyr Gly Ile Lys 100 105 110 Ser Val Val Pro Leu Ala Ile Gly Phe Ser Lys Tyr Pro Leu Lys Lys 115 120 125 Phe Leu Trp Leu Asn Val Phe Ser Ser Phe Leu Trp Ala Leu Ile Val 130 135 140 Gly Ser Val Ser Phe Gln Ala Ser Asp Trp Val Lys Thr Leu Tyr Glu 145 150 155 160 Arg Leu Ser His Tyr Thr Ser Phe Phe Val Ile Ser Phe Val Leu Ile 165 170 175 Ala Leu Leu Ile Trp Phe Leu Leu Lys Arg Tyr Ser Arg Lys Met Gly 180 185 190 Phe INFORMATION FOR SEQ ID NO:572: SEQUENCE CHARACTERISTICS: LENGTH: 140 amino acids TYPE: amino acid TOPOLOGY: linear N (ii) MOLECULE TYPE: protein Ml a brr% M tr^ r I- POT/US 96/09122 476 (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...140 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:572 Met Pro Phe Leu Lys Asn Trp Ile Trp Ser Leu Lys Met Ala Leu Ser 1 5 10 Ala Ile Ser Gly Ala Ser Gly Val Gly Lys Ser Val Leu Ile Ala Ser 25 Leu Leu Gly Ala Phe Gly Leu Lys Glu Ser Asn Ala Ser Asn Ile Glu 40 Val Glu Leu Ile Ala Pro Phe Leu Asp Thr Glu Glu Tyr Gly Ile Phe 55 Arg Glu Asp Glu His Glu Pro Leu Val Ile Ser Val Ile Lys Lys Glu 70 75 Lys Thr Arg Tyr Phe Leu Asn Gln Thr Ser Leu Ser Lys Asn Thr Leu 90 Lys Ala Leu Leu Lys Gly Leu Ile Lys Arg Leu Ser Asn Asp Arg Phe 100 105 110 Ser Gln Asn Glu Leu Asn Asp Ile Leu Met Leu Ser Leu Leu Asp Gly 115 120 125 Tyr Ile Gln Asn Lys Asn Lys Arg Leu Ala Pro Phe 130 135 140 INFORMATION FOR SEQ ID NO:573: SEQUENCE CHARACTERISTICS: LENGTH: 308 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...308 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:573 Met Pro Gln Asn Gln Leu Val Ile Thr Ile Ile Asp Glu Ser Gly Ser 1 5 10 Lys Gin Leu Lys Phe Ser Lys Asn Leu Lys Arg Asn Leu Ile Ile Ser 25 Val Val Ile Leu Leu Leu Ile Val Gly Leu Gly Val Gly Phe Leu Lys 40 Phe Leu Ile Ala Lys Met Asp Thr Met Thr Ser Glu Arg Asn Ala Val 55 Leu Arg Asp Phe Arg Gly Leu Tyr Gin Lys Asn Tyr Ala Leu Ala Lys 70 75 Glu Ile Lys Asn Lys Arg Glu Glu Leu Phe Ile Val Gly Gin Lys Ile 90 \Arg Gly Leu Glu Ser Leu lie Glu Ile Lys Lys Gly Ala Asn Gly Gly 96/091o2 477 -100 105 110 Gly His Leu Tyr Asp Glu Val Asp Leu Glu Asn Leu Ser Leu Asn Gin 115 120 125 Lys His Leu Ala Leu Met Leu Ile Pro Asn Gly Met Pro Leu Lys Thr 130 135 140 Tyr Ser Ala Ile Lys Pro Thr Lys Glu Arg Asn His Pro Ile Lys Lys 145 150 155 160 Ile Lys Gly Val Glu Ser Gly Ile Asp Phe Ile Ala Pro Leu Asn Thr 165 170 175 Pro Val Tyr Ala Ser Ala Asp Gly Ile Val Asp Phe Val Lys Thr Arg 180 185 190 Ser Asn Ala Gly Tyr Gly Asn Leu Val Arg Ile Glu His Ala Phe Gly 195 200 205 Phe Ser Ser Ile Tyr Thr His Leu Asp His Val Asn Val Gln Pro Lys 210 215 220 Ser Phe Ile Gln Lys Gly Gln Leu Ile Gly Tyr Ser Gly Lys Ser Gly 225 230 235 240 Asn Ser Gly Gly Glu Lys Leu His Tyr Glu Val Arg Phe Leu Gly Lys 245 250 255 Ile Leu Asp Ala Glu Lys Phe Leu Ala Trp Asp Leu Asp His Phe Gin 260 265 270 Ser Ala Leu Glu Glu Asn Lys Phe Ile Glu Trp Lys Asn Leu Phe Trp 275 280 285 Val Leu Glu Asp Ile Val Gln Leu Gln Glu His Val Asp Lys Asp Thr 290 295 300 Leu Lys Gly Gin 305 INFORMATION FOR SEQ ID NO:574: SEQUENCE CHARACTERISTICS: LENGTH: 339 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...339 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:574 Met Ile Thr Gly Ser His Asn Pro Lys Glu Tyr Asn Gly Phe Lys Ile 1 5 10 Thr Leu Asn Gln Asn Pro Phe Tyr Gly Lys Asp Ile Gln Ala Leu Lys 25 Asn Thr Leu Leu Asn Ala Lys His Glu Ile Lys Pro Leu Lys Glu Thr 40 Pro Glu Lys Val Asn Ala Leu Glu Ala Tyr His Arg Tyr Leu Ile Lys 55 Asp Phe Lys His Leu Lys Asn Leu Lys Tyr Lys Ile Ala Leu Asp Phe 70 75 Gly Asn Gly Val Gly Ala Leu Gly Leu Glu Pro Ile Leu Lys Ala Leu 90 Asn Ile Asp Phe Ser Ser Leu Tyr Ser Asp Pro Asp Gly Asp Phe Pro 0 100 105 110 S Asn His His sp PAsp Pro Ser Glu Ala Lys Asn Leu Lys Asp Leu Glu 115 120 125 M M AMENDED SHEET 16/09 122 478 Lys His Met.Arg Glu Asn Ala lile Leu Ile Gly Phe Ala Phe Asp Gly 130 135 140 Asp Ala Asp Arg Ile Ala Met Leu Ser Ser His His Ile Tyr Ala Gly 145 150 155 160 Asp Glu Leu Ala Ile Leu Phe Ala Lys Arg Leu His Ala Gln Gly Ile 165 170 175 Thr Pro Phe Val Ile Gly Glu Val Lys Cys Ser Gln Val Met Tyr Asn 180 185 190 Ala Ile Asn Thr Phe Gly Lys Thr Leu Met Tyr Lys Thr Gly His Ser 195 200 205 Asn Leu Lys Ile Lys Leu Lys Glu Thr Asn Ala His Phe Ala Ala Glu 210 215 220 Met Ser Gly His Ile Phe Phe Lys Glu Arg Tyr Phe Gly Tyr Asp Asp 225 230 235 240 Ala Leu Tyr Ala Cys Leu Arg Ala Leu Glu Leu Leu Leu Glu Gln Ser 245 250 255 Pro Ser Asp Leu Glu Asn Thr Ile Lys Asn Leu Pro Tyr Ser Tyr Thr 260 265 270 Thr Pro Glu Glu Lys Ile Ala Val Ser Glu Glu Glu Lys Phe Glu Ile 275 280 285 Ile Arg Asn Leu Gln Glu Ala Leu Lys Asn Pro Pro Ser His Phe Pro 290 295 300 Thr Ile Lys Glu Ile Ile Ser Ile Asp Gly Val Arg Val Val Phe Glu 305 310 315 320 His Gly Phe Gly Leu Ile Arg Ala Ser Asn Thr His Pro Leu Phe Ser 325 330 335 Gin Pro Leu INFORMATION FOR SEQ ID NO:575: SEQUENCE
CHARACTERISTICS:
LENGTH: 207 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix).FEATURE: NAME/KEY: misc_feature LOCATION 1...207 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:575 Met Ser Lys Asn Leu Gln Lys Lys Asn Pro Lys Lys Ser Unk Pro Gin 1 5 10 is Ala Gln Lys Ala Ile Arg Glu Met Lys Met Phe Glu Thr Ile Ala Phe 25 Tyr Phe Phe Ala Ile Leu Thr Leu Ser Met Ala Leu Val Val Ile Thr 40 Thr Thr Asn Ile Leu Tyr Ala Ile Thr Ala Leu Ala Ser Ser Met Val 55 Phe lie Ser Ala Phe Phe Phe Leu Leu Asp Ala Glu Phe Leu Gly Val 70 75 Val Gln Ile Thr Val Tyr Val Gly Ala Val Ile Val Met Tyr Ala Phe 90 Gly Met Met Phe Phe Asn Ser Ala Ala Glu Val Val Glu Arg Lys Gin 100 105 110 \Ser Pro Lys Ile Leu Cys Val Leu Ser Phe Gly Val Ala Leu Leu Leu PTUS 9 61/09 122 IPENJUS 18 D EC1996 Thr Val1 145 Gly Leu Lys 115-.
Ile Leu Ser Ala Pro 135 Ser Asn Ala Ile Asp 150 Val Leu Phe Thr Asn 165 Leu Leu Val Ala Met 180 His Gly Lys Asn His 195 120 Ser Ala Tyr Val1 Thr 200 Ile Unk Giu Gin Unk Pro 155 Leu Ile Pro 170 Gly Gly Ile 185 Gin Phe Ile As n 140 Asn Phe Ala Lys 125 Leu Ile Glu Thr Giu 205 INFORMATION FOR SEQ ID NO:576: SEQUENCE CHARACTERISTICS: LENGTH: 25i amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyiori (ix) FEATURE: (A),NAME/KEY: misc..feature LOCATION .251 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:576 Met Gly Ala Ile Leu Ser Ile Leu Lys Leu Giu Ile Lys Ser Tyr Leu 1 Thr Leu Tyr Ala Ile Leu Ile Asn Leu 145 Giu Met Gin Ile Thr 225 As n Leu Phe Ile Phe Ala Phe Phe 130 Phe Gin Ser Leu Lys 210 Phe Thr Leu Asn Phe Leu Leu Ile 115 Lys Cys Ser Cys Phe 195 Ala *Phe Ser Leu Asn Gly Phe Ile 100 Val Ala Phe Ile As n 180 Ile Phe Ile 5 Ala Ile Ile Leu Tyr Ala Leu Leu Cys Leu 165 Val1 Lys Gin Ile Thr 245 Leu Phe Ile Thr 70 Met Ser Ser Ile Leu 150 Gly Phe Thr G ly Gili 230 Phe Val Gly 55 Gin Leu Arg Phe Leu 135 Ala Phe Val1 Ser Ile 215 Gly rrp Phe 40 Leu Ala Ser Leu Tyr 120 Giy Ile Cys Pro Ile 200 Asp Ile Thr 25 Ser Met Ile Pro Ile 105 Ala Phe Phe Asn Leu 185 Phe Thr Ile Phe Lys Gly Thr Ala 90 Val Leu Ile Val1 Ile 170 *Giu *Tyr Sle Leu I le ksn Leu Ser 75 Thr Val1 Asn Ser Ala 155 Ile Tyr Tyl Let Ph 23' Tyr Thr Leu Ser Phe Ile Ile Ile 140 *Arg *Asn *Leu *Leu SVal 220 e Leu Pro rhr Ile Arg Lys Leu Ile 125 Phe Ile Leu Pro Asni 205 Leu Let Giu Ile Ile Ser Ser His Gin Ile Tyr Ala 110 Thr Ile Ser Ser Phe Gin Tyr Ala 175 Asn Ile 190 Gin Leu Ala Thr aSer Ala Phe Ser Asn Thr Phe Leu Ala Asn 160 Leu Gly Leu Ser As n 240 Arg Met Leu Leu Pro Lys Giu Arg Met Arg 250 AU~tkiflcmr cuLctfT PGT/Ub 96
L
IPENAUS 18 DEC1996 480 INFORMATION FOR SEQ ID NO:577: SEQUENCE
CHARACTERISTICS:
LENGTH: 69 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...69 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:577 Met Ala Gly Thr Gin Ala Ile Tyr Glu Ser Ser Ser Ala Gly Phe Leu 1 5 10 Ser Gin Val Ser Ser Ile Ile Ser Ser Thr Ser Gly Val Ala Gly Pro 25 Phe Ala Gly Ile Val Ala Gly Ala Met Thr Ala Ala Ile Ile Pro Ile 40 Val Val Gly Phe Thr Asn Pro Gin Met Thr Asp Ile Ile Asn Pro Ile 55 Lys Ser Lys His Arg INFORMATION FOR SEQ ID NO:578: SEQUENCE
CHARACTERISTICS:
LENGTH: 112 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...112 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:578 Val Ser Arg Ile Leu Gly Leu Ser Asp Asp Leu Ala Met Thr Leu Cys 1 5 10 Ala Glu Ser Ile Arg Ile Gln Ala Pro Ile Lys Gly Lys Asp Val Val 25 Gly Ile Glu Ile Pro Asn Ser Gin Ser Gin Ile Ile Tyr Leu Arg Glu 40 Ile Leu Glu Ser Glu Leu Phe Gin Lys Ser Ser Ser Pro Leu Thr Leu 55 Ala Leu Gly Lys Asp Ile Val Gly Asn Pro Phe Ile Thr Asp Leu Lys 70 75 7Lys Leu Pro His Leu Leu Ile Ala Gly Thr Thr Gly Ser Gly Lys Ser SAMENDED SHEET PCT/US 96/0 9 1 2.
IPEAAUS 18 DEC1996 481 90 Val Gly Val Asn Ala Met Ile Leu Ser Leu Leu Tyr Lys Lys Pro Pro 100 105 110 INFORMATION FOR SEQ ID NO:579: SEQUENCE
CHARACTERISTICS:
LENGTH: 152 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...152 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:579 Met Asp Glu Unk Leu Val Tyr Gly Val Ile Cys Met Pro Ser Gln Val 1 5 10 Phe Ala Asn Thr Gly Thr Asn Val Ser Ile Ile Phe Phe Gln Lys Thr 25 Pro Ser Ala Lys Glu Val Ile Leu Ile Asp Ala Ser Lys Leu Gly Glu 40 Glu Tyr Thr Glu Asn Lys Asn Lys Lys Thr Arg Leu Arg Pro Ser Asp 55 Met Asp Leu Ile Leu Glu Thr Phe Gln Asn Lys Ala Pro Lys Ser Asp 70 75 Phe Cys Ala Leu Val Ser Phe Asp Glu Ile Thr Glu Lys Asn Tyr Ser 90 Leu Asn Pro Gly Gln Tyr Phe Thr Ile Glu Asp Thr Ser Glu Thr Ile 100 105 110 Ser Gln Ala Glu Phe Glu Asn Leu Met Gln Gln Tyr Ser Ser Glu Leu 115 120 125 Ala Ser Leu Phe Asp Glu Ser Gln Asn Leu Gln Gln Glu Ile Leu Glu 130 135 140 Thr Leu Lys Gly Val Arg Phe Glu 145 150 INFORMATION FOR SEQ ID NO:580: SEQUENCE CHARACTERISTICS: LENGTH: 129 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...129 Aamkfrr-r? f til-'T IP ,UAib ouc 96 482 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:580 Met Arg Lys Gly Arg Val Met Leu Cys Val Phe Asp Ile GIu Thr Ile 1 5 10 Pro Asn Ile Ser Leu Cys Lys Glu His Phe Gin Leu Lys Glu Asp Asp 25 Ala Leu Lys Ile Cys Glu Trp Ser Phe Glu Lys Gin Lys Glu Lys Ser 40 Gly Ser Glu Phe Leu Pro Leu Tyr Leu His Glu Ile Ile Ser Ile Ala 55 Ala Val Ile Gly Asp Asp Tyr Gly Gln Phe Ile Lys Val Gly Asn Phe 70 75 Gly Gin Lys His Glu Asn Lys Glu Asp Phe Ala Ser Glu Lys Glu Leu 90 Leu Glu Asp Phe Phe Lys Tyr Phe Asn Glu Lys Gln Pro Arg Leu Ile 100 105 110 Ser Phe Unk Gly Arg Gly Phe Gly Tyr Ser Pro Thr His Ala Gin Ser 115 120 125 Pro INFORMATION FOR SEQ ID NO:580: SEQUENCE CHARACTERISTICS: LENGTH: 129 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...129 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:580 Met Arg Lys Gly Arg Val Met Leu Cys Val Phe Asp Ile Glu Thr Ile 1 5 10 Pro Asn Ile Ser Leu Cys Lys Glu His Phe Gln Leu Lys Glu Asp Asp 25 Ala Leu Lys Ile Cys Glu Trp Ser Phe Glu Lys Gin Lys Glu Lys Ser 40 Gly Ser Glu Phe Leu Pro Leu Tyr Leu His Glu Ile Ile Ser Ile Ala 55 Ala Val Ile Gly Asp Asp Tyr Gly Gln Phe Ile Lys Val Gly Asn Phe 70 75 Gly Gin Lys His Glu Asn Lys Glu Asp Phe Ala Ser Glu Lys Glu Leu 90 Leu Glu Asp Phe Phe Lys Tyr Phe Asn Glu Lys Gin Pro Arg Leu Ile 100 105 110 Ser Phe Unk Gly Arg Gly Phe Gly Tyr Ser Pro Thr His Ala Gln Ser 115 120 125 Pro 0(2) INFORMATION FOR SEQ ID NO:581: SEQUENCE CHARACTERISTICS: AMENDED
SHEET
PCT/US 96/0912.
483 EU- LENGTH: 113 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii)- HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...113 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:581 Met Arg Arg Ile Ile Lys Asn Thr Leu Ser Arg Leu Gly Tyr Glu Asp 1 5 10 Val Leu Glu Ala Glu His Gly Val Glu Ala Trp Glu Lys Leu Asp Ala 25 Asn Ala Asp Thr Lys Val Leu Ile Thr Asp Trp Asn Met Pro Glu Met 40 Asn Gly Leu Asp Leu Val Lys Lys Val Arg Ala Asp Asn Arg Phe Lys 55 Glu Ile Pro Ile Ile Met Ile Thr Thr Glu Gly Gly Lys Ala Glu Val 70 75 Ile Thr Thr Leu Lys Ala Gly Val Asn Asn Tyr Ile Val Lys Pro Phe 90 Thr Pro Gin Val Leu Lys Glu Lys Leu Glu Val Val Leu Gly Thr Asn 100 105 110 Asp INFORMATION FOR SEQ ID NO:582: SEQUENCE CHARACTERISTICS: LENGTH: 174 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...174 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:582 Met Ala Glu Glu Gln Glu Asn Thr Ala Gin Gln Pro Gin Lys Lys Ser 1 5 10 Lys Ala Leu Leu Phe Val Ile Ile Gly Ser Val Leu Val Met Leu Leu 25 Leu Val Gly Val Ile Ile Met Leu Leu Met Gly Asn Lys Glu Glu Ser 40 Lys Glu Asn Ala Ser Lys Asn Thr Gln Glu Val Gin Ala Asn Pro Met 55 cRA Ala Asn Lys Asn Gln Glu Ala Lys Glu Gly Ser Asn Ile Gin Gin Tyr 70 75 K>vI QAMFNDFE SHEET PCT/US 9 6 0 9 12 2 IPEA/ U 1ouc- 16 484 Leu Val Leu.Gly Pro Leu Tyr Ala Ile Asp Ala Pro Phe Ala Val Asn 90 Leu Val Ser Gin Asn Gly Arg Arg Tyr Leu Lys Ala Ser Ile Ser Leu 100 105 110 Glu Leu Ser Asn Glu Lys Leu Leu Asn Glu Val Lys Val Lys Asp Thr 115 120 125 Ala Ile Lys Asp Thr Ile Ile Glu Ile Leu Ser Ser Lys Ser Val Glu 130 135 140 Glu Val Val Thr Asn Lys Gly Lys Asn Lys Leu Lys Asp Glu Ile Lys 145 150 155 160 Ser His Leu Asn Ser Phe Leu lie Asp Gly Phe Ile Lys Asn 165 170 INFORMATION FOR SEQ ID NO:583: SEQUENCE
CHARACTERISTICS:
LENGTH: 35 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...35 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:583 Met Gly Cys Phe Ser Thr Ile Cys Cys Lys Gly Leu Thr Leu Ser Val 1 5 10 Gly Gly Phe Leu Val Met Met Arg Phe Leu Ile Phe Lys Asp Phe Cys 25 Lys Asp Phe INFORMATION FOR SEQ ID NO:584: SEQUENCE CHARACTERISTICS: LENGTH: 307 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...307 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:584 Met Ala Lys Lys Lys Ile Ala Ile Ser Cys Gly Asp Ile Gin Gly Val 1 5 10 Gly Leu Glu Leu Ile Leu Lys Ser His Lys Glu Val Ser Ala Leu Cys PCT/U~ 9
~OK
GlU Leu Asp Thr Leu Lys Phe Cys 145 Ala Ala Asn Ilie Phe 225 Lys Pro Ala Ala 305 Pro Leu Tyr Leu Asp Asn Ala-~Pro Leu Gin Ser Gly Ala Asp Ser 100 Leu Ala Trp 115 Leu Lys Gin 130 Ser Lys Leu Val Ser Gin Phe Gin Lys 180 Pro His Ala 195 Leu Lys Ala 210 Leu Gly Pro Ilie Thr Pro Leu Lys Ala 260 Pro Ile Leu 275 Tyr Gin Asn 290 Leu Ala Leu Val His Ser Giu Leu Leu Ala pro Ala Lys Gin Arg Phe Leu 165 Ser Gly Ile Leu Phe 245 Leu Arg Lys Tyr Leu 70 Tyr Giu Gin Tyr Vali iso Ile Thr Giu Gin Pro 230 Tyr Tyr Ala Ala Giu 55 Leu Ser Vai Ala Lys 135 Gly Gin Gin Giu Giu 215 Aia Vali Phe Ser Asn 295 40 Thr PAsn Phe Asp Gln 120 Asp Leu Val1 Ala Gly 200 Ser Asp Ser Asp Thr 280 His Lys Ser Glu Gly 105 Ile His Phe Lys Lys 185 Leu Asn Ser Met Giu 265 Asp Lys rhr Ser Ser 90 Ile Pro Gin Ser Ala 170 Ile Phe Gin Ala Ser 250 Ser His Ser Leu Thr 75 Phe Cys Phe Ile Asp iSS Leu Vai Gly Thr Phe 235 His I le Giy Tyr Giu Asn Ile Lys Thr Val1 Ile 140 His Vali Gin Giu Leu 220 Ala Asp Asn *Thr *Let 300 Arg2 Ala Giy Lys LetA Gly 125 Met Val Lys Val1 Giu 205 Gly Pro Val Val Ala 285 Asn kla Ile Lys Ala Pro 110 His Met Pro Phe Cys 190 Asp Phe Asn Giy Ser 270 Phe Ala Alia Val1 Cys Ile Thr Leu Leu Leu 175 Gly Giu Giu Lys Leu 255 Let Ast Iil Gin Ile Ser Clu Asn Asp Gly Ser 160 Leu Phe Lys Cys Arg 240 Ala :Asn Sle a Lys INFORMATION FOR SEQ ID NO:584: SEQUENCE CHARACTERISTICS: LENGTH: 307 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .307 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:584 Met Aia Lys Lys Lys Ile Ala Ile Ser Cys Gly Asp Ile Gin Giy Val 1 5 10 Gly Leu Glu Leu Ile Leu Lys Ser His Lys Glu Val Ser Ala Leu Cys 25 Giu Pro Leu Tyr Leu Vai His Ser Glu Leu Leu Glu Arg Ala Asn Gin 40 I EI rr~7 POT/UJS 9 6 09 1Z I PEANs 6 i w.i, Z0 Leu Leu Asp'-Asn Ala Tyr Glu Thr Lys Thr Leu Asp.
Thr Leu Lys Phe Cys 145 Ala Ala Asn Ile Phe 225 Lys Pro Ala Ala Tyr 305 Ala Gin Ala Leu Leu 130 Ser Val1 Phe Pro Leu 210 Leu Ile Leu Pro Tyr 290 Leu Pro Ser Asp Ala 115 Lys Lys Ser Gin His 195 Lys Gly Thr Lys Ile 275 Gin Ala Leu Gly Ser 100 Trp Gin Leu Gin Lys 180 Ala Ala Pro Pro Ala 260 Leu Asn Pro Ala Lys Gin Arg Phe Leu 165 Ser Gly Ile Leu Phe 245 Leu Arg Lys Leu 70 Tyr Giu Gin Tyr Val1 150 Ile Thr Giu Gin Pro 230 Tyr Tyr Ala Ala Leu Ser Val1 Ala Lys 135 Gly Gin Gin Giu Giu 215 Ala Val1 Phe Ser Asn 295 Asn Phe Asp Gin 120 Asp Leu Val Ala Gly 200 Ser Asp Ser Asp Thr 280 His Ser Glu Gly 10s Ile His Phe Lys Lys 185 Leu Asn Se r Met Giu 265 Asp Lys Ser Ser 90 Ile Pro Gin Ser Ala 170 Ile Phe Gin Ala Ser 250 Ser His Ser Thr 75 Phe Cys Phe Ile Asp 155 Leu Vai Gly Thr Phe 235 His Ile G ly Tyr Asn Ile Lys Thr Val1 Ile 140 His Val1 Gin Giu Leu 220 Ala Asp Asn Thr Leu 300 Gly Lys Leu Gly 125 Met Val1 Lys Val1 Giu 205 Gly Pro Val1 Val1 Ala 285 Asn Lys Ala Pro 110 His Met Pro Phe Cys 190 Asp Phe As n Gly Ser 270 Phe Ala Val Cys Ile Thr Leu Leu Leu 175 Gly Giu Giu Lys Leu 255 Leu Asp Ile Ser Glu Asn Asp Gly Ser 160 Leu Phe Lys Cys Arg 240 Ala Asn Ile Lys Alia Ile Ala Ile INFORMATION FOR SEQ ID NO:585: SEQUENCE CHARACTERISTICS: LENGTH: 702 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .702 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:585 Val Ala Arg Leu Val Val Lys Arg Arg Lys Ile Asp Tyr Lys Gin Sen 1 S5 10 is Ile Gin Sen Asp Ser Gin Tyr Leu Gin Ala Unk Leu Asn Gin Phe Glu 25 Asn Lys Giu Val Tyn Giu Asn Gin Tyr Phe Leu Val Leu Giu Ser Thr 40 His Sen Leu His Gly Val Leu Giu His Lys Lys Lys Ser Phe Met His 55 Ala Asn Arg Giu Asn Phe Lys Asp Ile Leu Ser Tyr Lys Ala His Phe SCTiUS 96/ 09 487 70 75 Leu Gln Glu Thr Leu Lys Ser Leu Glu Ile Gln Leu Lys Asn Tyr Ala 90 Pro Lys Leu Leu Asn Ser Lys Glu Val Leu Asn Phe Tyr Ala Glu Tyr 100 105 110 Ile Asn Gly Phe Glu Leu Pro Leu Lys Pro Leu Val Gly Gly Tyr Leu -115 120 125 Ser Asp Ser Tyr Ile Ala Ser Ser Ile Thr Phe Glu Lys Asp Tyr Phe 130 135 140 Ile Gln Giu Ser Phe Asn Gin Lys Thr Tyr Asn Arg Leu Ile Gly Ile 145 150 155 160 Lys Ala Tyr Glu Ser Glu Arg Ile Thr Ser Ile Ala Val Gly Ala Leu 165 170 175 Leu Tyr Gin Glu Thr Pro Leu Asp Ile Ile Phe Ser Ile Glu Pro Met 180 185 190 Ser Val Asn Lys Thr Leu Ser Phe Leu Lys Glu Arg Ala Lys Phe Ser 195 200 205 Met Ser Asn Leu Val Lys Asn Glu Leu Leu Glu Tyr Gln Glu Leu Val 210 215 220 Lys Thr Lys Arg Leu Ser Met Gln Lys Phe Ala Leu Asn Val Leu Ile 225 230 235 240 Lys Ala Pro Ser Leu Glu Asp Leu Asp Ala Gln Thr Ser Leu Ile Leu 245 250 255 Gly Leu Leu Phe Lys GIu Asn Leu Val Gly Val Ile Glu Thr Phe Gly 260 265 270 Leu Lys Gly Gly Tyr Phe Ser Phe Phe Pro Glu Arg Ile His Leu Asn 275 280 285 His Arg Leu Arg Phe Leu Thr Ser Lys Ala Leu Ala Cys Leu Met Val 290 295 300 Phe Glu Arg Gln Asn Leu Gly Phe Lys Ala Asn Ser Trp Gly Asn Ser 305 310 315 320 Pro Leu Ser Val Phe Lys Asn Leu Asp Tyr Ser Pro Phe Leu Phe Asn 325 330 335 Phe His Asn.Gln Glu Val Ser His Asn Asn Ala Lys Glu Ile Ala Arg 340 345 350 Val Asn Gly His Thr Leu Val Ile Gly Ala Thr Gly Ser Gly Lys Ser 355 360 365 Thr Leu Ile Ser Tyr Leu Met Met Ser Ala Leu Lys Tyr Gin Asn Met 370 375 380 Arg Leu Leu Ala Phe Asp Arg Met Gln Gly Leu Tyr Ser Phe Thr Glu 385 390 395 400 Phe Phe Lys Gly His Tyr His Asp Gly Gln Ser Phe Ser Ile Asn Pro 405 410 415 Phe Cys Leu Glu Pro Asn Leu Gin Asn Leu Glu Phe Leu Gin Ser Phe 420 425 430 Phe Leu Ser Met Leu Asp Leu Ala Pro Ser Arg Asp Lys Glu Ala Leu 435 440 445 Glu Asp Met Asn Ala Ile Ser Gly Ala Ile Lys Ser Leu Tyr Glu Thr 450 455 460 Leu Tyr Pro Lys Asp Phe Ser Leu Leu Asp Phe Lys Glu Thr Leu Lys 465 470 475 480 Arg Thr Ser Ser Asn Gln Leu Gly Leu Ser Leu GIu Pro Tyr Leu Asn 485 490 495 Asn Pro Leu Phe Asn Ala Leu Asn Asp Ala Phe Asn Ser Asn Ala Phe 500 505 510 Leu Asn Val Ile Asn Leu Asp Ala Ile Thr Gln Asn Pro Lys Asp Leu 515 520 525 Gly Leu Leu Ala Tyr Tyr Leu Phe Tyr Lys Ile Leu Glu Glu Ser Arg 530 535 540 Lys Asn Asp Ser Gly Phe Leu Val Phe Leu Asp Glu Phe Lys Ser Tyr 545 550 555 560 Val Glu Asn Asp Leu Leu Asn Thr Lys Ile Asn Ala Leu Ile Thr Gin 565 570 575 Ala Arg Lys Ala Asn Gly Val Val Val Leu Ala Leu Gln Asp Ile Tyr 580 585 590 AMENDED SHEET POT/US 9 6/09 12.2 IPENUJS 18 0 0s Gin Thr Phe 625 Pro Ser Ile Lys Ser. Giy 595 Ilie Leu Val Pro Tyr Aia Met Ile 660 Asn Ser 675 Tyr Pro Vali Tyr Leu Arg 645 Asp Asp Thr Ser Aia Ile Lys 650 Giy Asn Lys 488 Phe Leu Arg Glu 620 Ser Phe 635 Asn Leu Leu Giy Lys Vai Leu Leu 700 Asnr Lys Giu Asn Tyr 670 Ala Ser Met His Asn Giy 655 Leu Leu INFORMATION FOR SEQ ID NO:586: SEQUENCE CHARACTERISTICS: LENGTH: 293 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Heiicobacter pyiori (ix) FEATURE: NAME/KEY: misc-feature LOCATION i. .293 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:586 Met Gin Oiu Asp Trp Gin Aia Vai Gin Asp Thr Ile Lys Vai Vai Ser 1 Asp Ser Tyr Phe Ser Lys Ser Ser Thr 145 Gin Asp Aia Lys Vali Pro Leu Giu Giy Met Aia Gin 130 Thr Giy Gin Giy Leu Lys Asp Gin Ser Arg Leu Asn 11s His Ser Lys Thr Giu 195 Ala Aia Leu Giu Tyr Val1 Giu 100 Leu Lys Ile Asp As n 180 His Giu 5 Giy Lys Ser Ser Giu Thr Lys Ser Gin Ile 165 Leu Giy Arg Asn Glu Vai G ly 70 Leu Ser Giu Leu Giy 150 Lys Leu Arg Thr Phe Leu Gly 55 Leu Val Ser Cys Met i3 5 Vai Ser Aia Giy Gin Ala Arg 40 Thr Asp Thr Asn Vai 120 Glu Ser Ile Leu Phe 200 Lys Vali 25 Asp His Phe Asn Phe 105 Gin Thr Ser Vai Asn 185 Aia Ser 10 Arg Aia Met Arg Aia 90 Ala Asn Ser Gin Giu 170 Ala Val1 Leu Ile Thr Ala Giu Pro Ala Leu Pro Gly 75 Leu Lys Leu Lys Ser 155 Ile Ala Val1 Ser Thr Asn Giy Ile Met Unk Ser Ile Phe Lys Ile Arg Ile Gin Asn Ala Gly Gin Giu Ile Gin Asp Leu Ala Asn Asp 110 Giu Lys Ala Ser Asn 125 Thr Ile Giu Asn Ile 140 Giu Ala Met Ile GlU 160 Ile Arg Asp Ile Ala 175 Ile Glu Ala Ala Arg 190 Ala Asp Giu Val Arg 205 Glu Ile Giu Ala Asn 220 Ser Glu Ser Ile Lys 210 215 Ile Asn Ile Leu Val Gin Ser Ile Ser Asp IPEAUS 18 DEC 1996 489 225 230 235 240 Asn Gln Val Lys Glu Val GIu Glu Ile Asn Ala Ser Ile Glu Ala Leu 245 250 255 Arg Ser Val Thr Glu Gly Asn Leu Lys Ile Ala Ser Asp Ser Leu Glu 260 265 270 Ile Ser Gln Glu Ile Asp Lys Val Ser Asn Asp Ile Leu Glu Asp Val 275 280 285 Asn Lys Lys Gln Phe 290 INFORMATION FOR SEQ ID NO:587: SEQUENCE CHARACTERISTICS: LENGTH: 52 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...52 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:587 Met Pro Lys Ser Phe Thr Leu Pro Thr Phe Val Trp Cys Leu Phe Val 1 5 10 Gly Val Ile Leu Arg Asn Ala Leu Ser Phe Phe Lys Ile His Ser Val 25 Phe Asp Arg Glu Val Ser Val Ile Gly Asn Val Ser Leu Ser Leu Phe 40 Leu Ala Tyr Ala INFORMATION FOR SEQ ID NO:588: SEQUENCE CHARACTERISTICS: LENGTH: 182 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...182 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:588 Val Gly Leu Leu Asn Ser Lys Ala Phe Lys Pro Tyr Arg Lys Ile Leu 1 5 10 Gn Met Val Phe Gln Asp Pro Tyr Ala Ser Leu Asn Pro Arg Leu Ser 25 lkcknrnr ni
T~~
9 6 /09122 Fpvaps18 DEC 1996 Ilie Ser Cys Giy Arg Gin Leu Cys 145 Ala Leu Gin Gin Leu Giu Ile Lys Ser 130 Asp Ile Leu Ser Ile Gin Giu Asn Pro Arg Gin Ile Leu 100 Ser Vai 115 Tyr Leu Arg Val Giu Giu Giu Ser 180 Leu Trp Giu Arg Leu Leu Phe Leu Vai 165 Arg Ile His Leu 70 Val1 Asp Giu Ilie Val1 150 Phe Leu GiU His 55 Leu Aia Giu Leu Ser 135 Val1 Asp Aia 40 Leu Asn Ile Pro Leu 120 His Ser Asn Leu Ala Phe Ala Thr 105 Leu Asp Giu Pro Arg Giu Tyr Arg 90 Ser Asn Leu Gly Lys 170 490 Phe Ala Leu Cys Ala Tyr 75 Ala Ile Ala Leu Leu Gin Asp Val 140 Lys Ile 155 His Ala Tyr Leu Glu Aia Asp Giu 125 Ile Vali Tyr Pro GlU Leu Leu Lys 110 Lys Lys Giu Thr Lys Glu Ser Lys Ser Gin Aia Thr Lys 175 Ala Vai Gly Pro Ile Asp Phe Gly 160 Arg INFORMATION FOR SEQ ID NO:589: SEQUENCE CHARACTERISTICS: LENGTH: 251 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Heiicobacter pyiori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .251 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:589 Val Ser Leu Ile Lys Vai Ser Gly Asp 1 Ile Aia Ser Lys His Giu Leu Asp Giy 145 Ser Pro Phe Leu Asp Phe Met Giu Asn 130 Met Phe Leu Ser Lys Lys Leu Ile As n 115 Phe Asp Asp Thr Asp His Giu Gly Tyr 100 Thr Met Phe Asp 5 Ser Tyr Tyr Lys Ala Tyr Leu Ile Glu As n 165 Ile Ser Gly Gly Val Phe 70 Asn Ala Lys Thr Leu 150 Giu Ile Giu 55 Giu Asn Lys Phe Arg 135 Ser Leu Ser 40 Trp Leu Lys Arg Leu 120 Giu Arg Ser Lys 25 Thr Gin Thr Val1 Leu 105 Glu Arg Ile Giu Lys 10 Aia Ala Ile Thr Lys 90 Gly Lys Phe Ser Ile 170 Arg Thr Gly Leu 75 Thr Leu Gin Arg Tyr Val1 Lys Val Ile Giu Val Arg Tyr Lys Leu Ile Lys Ser 140 Pro Ile Lys Lys Asp Asp Tyr Ser Gin 125 His Leu Lys Ile Ile VIal Giu Giu Leu 110 Phe Gin Leu Glu Val Arg Pro Pro Lys Leu Giu Ile Phe Ile Gin 175 Ser His Phe Ile Tyr Asn Giu Giy His 160 Gin Gly Ser Lys Thr Gin Ala Met Leu Tyr Phe Cys Phe Ser Ile Leu 491PEA/US 18 DEC 1996 491 -180 185 190 Glu Leu Lys Thr Ala Thr Pro Leu Leu Asn Arg Thr Ala Met Pro Lys 195 200 205 Glu His Ala Leu Leu Ile Ile His Glu Thr Asn Ala Leu Val Phe Leu 210 215 220 Glu Met Leu Lys Ile Phe Gly Leu Leu Ser Gln Val His His Asn Asp 225 230 235 240 Val Leu Lys Ile Leu Glu Lys Ile Leu Gln Asn 245 250 INFORMATION FOR SEQ ID NO:590: SEQUENCE CHARACTERISTICS: LENGTH: 40 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...40 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:590 Val Ile Thr Ala Cys Phe Asn Arg Glu Lys Thr Ile Glu Asp Thr Ile 1 5 10 Leu Ser Val Leu Asn Gln Thr Tyr Lys Asn Ile Glu Tyr Ile Ile Ile 25 Asp Gly Ala Ser Ala Ile Ala Leu INFORMATION FOR SEQ ID NO:591: SEQUENCE CHARACTERISTICS: LENGTH: 122 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...122 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:591 Val Phe Val Gly Leu Tyr His Gly Ala Ser Ile Phe Asp Leu Lys Phe 1 5 10 Glu Val Tyr Leu Thr Met Leu Ile Ser Leu Met Pro Phe Val Ala Thr 25 Ile Tyr Ile Asn Phe Pro Lys Thr Thr Glu Thr Ser His Gly Tyr Ala 40 PCT/US 9 6 /0 9 IPEA/US 1 C 99G 492 Arg Trp Ala Asn Val Lys Asp Ile Glu Cys Phe Lys Ile Phe Ser Lys 55 Glu Gly Phe Cys Lys Val Val His Arg Leu Gly Val Gln Phe Asp Asn 70 75 Gly Phe Ile Leu Gly Lys Phe Gly Phe Pro Lys Leu Arg Asn Val Cys 90 Tyr Asp Lys Pro Leu Gly Thr Met Ile Val Ala Pro Pro Gly Ala Glu 100 105 110 Lys Leu His Val Trp Leu Cys Gin Ile Tyr 115 120 INFORMATION FOR SEQ ID NO:592: SEQUENCE CHARACTERISTICS: LENGTH: 113 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...113 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:592 Met Lys Arg Leu Ala Val Ala Leu Ile Leu Val Leu Gly Val Val Trp 1 5 10 Gly Lys Ser Leu Pro Lys Trp Ala Lys Asp Cys Ser Lys Glu Met Arg 25 Ile Glu Lys Thr Gln Thr Lys Asp Glu Lys Ile Leu Val Cys Gly Met 40 Ser Asp Ile Leu Leu Ser Asp Met Asp Tyr Ser Leu Ser Ser Ala Arg 55 Gin Asn Ala Leu Glu Lys Val Met Glu Ala Phe Lys Gly Asp Arg Ile 70 75 Glu Ile Lys Ala Gly Glu Leu Lys Ala Thr Phe Ile Asp Thr Asp Lys 90 Val Tyr Val Leu Leu Arg Ile Thr Lys Lys His Val Ala Leu Met Asn 100 105 110 Glu INFORMATION FOR SEQ ID NO:593: SEQUENCE CHARACTERISTICS: LENGTH: 437 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori S(ix) FEATURE: y ff K) #I9S 9 6 /09122 IPEA/US 18 DEC1996 NAME/KEY: miscfeature LOCATION .437 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:59 3 Met Asn Pro Gin Ile Gin Pro Ala Thr Lys Lys 1 Leu A Tyr A Asp P Phe P Lys Leu C Glu I Ser N Gly 145 Leu Asn Phe Ile Asn 225.
Ser Gly Leu Ser Leu 305 Val Ile Ala Ala Tyr 385 Leu Met la la ro 0 he Lys ly Trp Val 130 ,ys Val Val Ala Met 210 Val Leu Leu Lys Phe 290 Cys Phe Lys Leti Glt 370 Ala Gl Le Ala S 2 Phe L Thr I Met I Gly I Ser I Ala 115 Gly C Asn Gly Tyr Leu 195 Glu Asn Lys Thr Ile 275 Ile Gly Ala His Ser 355 Leu Ile x Phe a Ser 5 er S 0 eu I eu Arg Arg Phe L00 ?he Gly ;ly iy rhr 180 Glu Glu Asn Glu Met 260 Phe Met Met Ile Ala 340 Ser Phe Ala Lys Ile er la Ala Pro Lys let Leu Glu Lys .In 165 His Gly Thr Thr Leu 245 Gly Leu Leu Leu Thr 325 Thi Met Pr As 01 Gly Pro Leu Leu C 70 Thr Leu Phe Tyr Lys iso Leu Giu Ile Met Lys 230 Leu Gly Thr Leu Ala 310 Gly Ser Ser o Glu n Ala 390 n His 5 Asn L Tyr P 4 [le S Gly S 3er M Ala L Leu L 1 135 Giy F Leu I Gln Leu Asp 215 Glu Asn Ser Asn Ala 295 Asp Leu Val Phe His 375 Leu Gly eu he 0 er er et eu eu 20 ral Phe Ala le Ala a00 Asn rhr His Leu Ser 280 Leu Lys Ile Ty Ty 36 Va Ph Ph 1 Val G 25 Ala L Ala P Leu P Val 9 Leu I 105 Leu Val I Tyr C Ile Ser 185 Leu Giu His Lys Cys 265 Ser Ser Ile Val Glu 345 r Thr 0 1 Arg e Gly e Glu 0 lu I ys C he I he 1 7 yr 10 'ro la I Ala ;ly ?he 170 Ala Leu Ala Ile Lys 250 Phe Ser Tyr Lys Thr 330 Ala Cys Ala Gly Glu 410 rp lu Leu Phe 5 Ser Thr Arg Thr Ser 155 Ser Phe Ser Thr Lys 235 Ala Tyr Phe Phe Arg 315 Pro Let I1 Le Se 39 G1 Pro L Tyr A Phe T 4 Val P Gly L Ile I Lys G Leu L 1 Tyr L 140 Phe G Leu P Ala I Leu I Pro 220 Glu Leu Thr Ser Ile 300 Thr Ile Phe e Ala I Gly 380 r Ala 5 y Phe eu L sp P 3 hr H he M ys L le L lu I 1 eu G eu S 1n 1 he Trp Phe 205 G1n Thr 4et Phe Pro 285 Phe Gin Val Tyr Gly 365 Val Ser Val ys he 0 is e t eu eu le in er yr Ile Arg 190 Leu Lys .In Ile Thr 270 Lys Leu Met Phe G1 35 Va Gl Ty Gl Ser L Tyr A Thr A Leu G Gly A 8 Met A Val G Gly P Glu I Val Val 175 Tyr Arg Lys Arg Val 255 Val Glu Gin Leu Tyr 335 i Ile 0 l Ile y Leu r Ile y Tyr 415 eu la sn ly sp 0 la ly he Leu Thr Glu Leu Asn Thr Gly 240 Phe Tyr Ser Pro Met 320 Gly Leu Lys Ala Ala 400 Val Val Ile Phe Met Val 425 Met Val Ile Ile Phe Pro Lys 430 Lys Thr Tyr Leu Glu 435 INFORMATION FOR SEQ ID NO:594: AM NDED SHEET PCT/US 9 6 09 12 IPEA/US 18 DEC 1996 494 SEQUENCE
CHARACTERISTICS:
LENGTH: 146 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...146 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:594 Met Ser Ser Gly Leu Ile Tyr Ile Ser Leu Glu Val Leu Val Unk Cys 1 5 10 Leu Ile Thr Ala Leu Ile Met Tyr Tyr Val Met Lys Lys Ile Tyr Tyr 25 Ala Arg Gly Gln Ala Ile Leu Lys Gly Ala Ser Ala Lys Ala Lys Leu 40 Met Glu Phe Gln Ala Lys Ser Phe Val Glu Ala Glu Glu Met Arg Met 55 Lys Ser Gln Glu Cys Lys Leu Gln Gln Gln Tyr Glu Asn Lys Asn Leu 70 75 Gin Leu Gln Thr His Phe Asp Lys Lys Glu Ala His Leu Lys His Leu 90 Glu Ala Gln His Lys Glu Phe Val Arg Asp Glu Lys Arg Tyr Leu Glu 100 105 110 Lys Glu Lys Lys Glu Leu Glu Lys Glu Arg Gln Ile Leu Glu Unk Glu 115 120 125 Arg Glu Asn Phe Unk Unk Gln Arg Ala Phe Val Unk Unk Unk Unk Ala 130 135 140 Lys Ala 145 INFORMATION FOR SEQ ID NO:594: SEQUENCE CHARACTERISTICS: LENGTH: 146 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...146 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:594 Met Ser Ser Gly Leu Ile Tyr Ile Ser Leu Glu,Val Leu Val Unk Cys 1 5 10 Leu Ile Thr Ala Leu Ile Met Tyr Tyr Val Met Lys Lys Ile Tyr Tyr 25 Ala Arg Gly Gln Ala Ile Leu Lys Gly Ala Ser Ala Lys Ala Lys Leu PCT/US 9 6 0912 IPEA/US 18 DEC 1996 495 40 Met Glu Phe Gln Ala Lys Ser Phe Val Glu Ala Glu Glu Met Arg Met 55 Lys Ser Gln Glu Cys Lys Leu Gln Gln Gln Tyr Glu Asn Lys Asn Leu 70 75 Gin Leu Gln Thr His Phe Asp Lys Lys Glu Ala His Leu Lys His Leu 90 Glu Ala Gln His Lys Glu Phe Val Arg Asp Glu Lys Arg Tyr Leu Glu 100 105 110 Lys GIu Lys Lys Glu Leu Glu Lys Glu Arg Gin Ile Leu Glu Unk Glu 115 120 125 Arg Glu Asn Phe Unk Unk Gin Arg Ala Phe Val Unk Unk Unk Unk Ala 130 135 140 Lys Ala 145 INFORMATION FOR SEQ ID NO:595: SEQUENCE CHARACTERISTICS: LENGTH: 127 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...127 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:595 Met Asn Ile Lys Ile Leu Lys Ile Leu Val Gly Gly Leu Phe Phe Leu 1 5 10 Ser Leu Asn Ala His Leu Trp Gly Lys Gln Asp Asn Ser Phe Leu Gly 25 Ile Gly Glu Arg Ala Tyr Lys Ser Gly Asn Tyr Ser Lys Ala Ala Ser 40 Tyr Phe Lys Lys Ala Cys Asn Asp Gly Val Ser Glu Gly Cys Thr Gin 55 Leu Gly Ile Ile Tyr Glu Asn Gly Gln Gly Thr Arg Ile Asp Tyr Lys 70 75 Lys Ala Leu GIu Tyr Tyr Lys Thr Ala Cys Gin Ala Asp Asp Arg Glu 90 Gly Cys Phe Gly Leu Gly Gly Leu Tyr Asp Glu Gly Leu Gly Thr Ala 100 105 110 Gin Asn Tyr Gin Glu Ala Unk Asp Ala Tyr Ala Arg His Ala Phe 115 120 125 INFORMATION FOR SEQ ID NO:595: SEQUENCE CHARACTERISTICS: LENGTH: 127 amino acids TYPE: amino acid TOPOLOGY: linear RA (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES ___AMENDFD qHFFT IPEAMJS 18 DEC1996 496 (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE:' NAME/KEY: misc_feature LOCATION 1...127 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:595 Met Asn Ile Lys Ile Leu Lys Ile Leu Val Gly Gly Leu Phe Phe Leu 1 5 10 Ser Leu Asn Ala His Leu Trp Gly Lys Gln Asp Asn Ser Phe Leu Gly 25 Ile Gly Glu Arg Ala Tyr Lys Ser Gly Asn Tyr Ser Lys Ala Ala Ser 40 Tyr Phe Lys Lys Ala Cys Asn Asp Gly Val Ser Glu Gly Cys Thr Gin 55 Leu Gly Ile Ile Tyr Glu Asn Gly Gln Gly Thr Arg Ile Asp Tyr Lys 70 75 Lys Ala Leu Glu Tyr Tyr Lys Thr Ala Cys Gln Ala Asp Asp Arg Glu 90 Gly Cys Phe Gly Leu Gly Gly Leu Tyr Asp Glu Gly Leu Gly Thr Ala 100 105 110 Gin Asn Tyr Gln Glu Ala Unk Asp Ala Tyr Ala Arg His Ala Phe 115 120 125 INFORMATION FOR SEQ ID NO:596: SEQUENCE CHARACTERISTICS: LENGTH: 95 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...95 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:596 Met Asp Ile Ser Ile Phe Arg Glu Tyr Asp Ile Arg Gly Ile Tyr Pro 1 5 10 Thr Thr Leu Asp Glu Asn Thr Ala Phe Ser Ile Gly Val Glu Leu Gly 25 Lys Ile Met Arg Glu Tyr Asp Lys Ser Val Phe Val Gly His Asp Ala 40 Arg Val His Gly Arg Phe Leu Phe Glu Val Leu Ser Ala Gly Leu Gin 55 Ser Ser Gly Leu Lys Val Tyr Asp Leu Gly Leu Ile Pro Thr Pro Val 70 75 Ala Tyr Phe Ala Ala Phe Asn Glu Ile Asp Asn Ile Gln Trp Pro 90 INFORMATION FOR SEQ ID NO:597: SEQUENCE CHARACTERISTICS: PCT/US 96/0912.1 IPEA/US 18 DEC1996 LENGTH: 102 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...102 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:597 Cys Asp Ile Phe Ser Asp Gly Val Leu Leu 5 Tyr Phe Lys Ala Pro Tyr Ser Phe Thr Gly 25 Gin Cys His Gly Ser Pro Leu Leu Ala Gin 40 Leu Asn Leu Gly Ala Arg Leu Ala Lys Ala 55 Ala Phe Leu Asn His Lys Met Asp Leu Ser 70 75 1 Gin Leu Ile Leu Cys Glu Asp Glu Ser Val 90 g Gin Leu Gin Gly Gly 100 Val 1 Ile Ile Cys Lys Va Arg Asp Lys Glu Asp Asn Ile Gly Glu 60 Glu Ile Leu Asn Ala Val Leu Phe Glu Ala Leu 15 Cys Gin Ser Ala Leu Val Glu Ala Lys Ser Ala INFORMATION FOR SEQ ID NO:598: SEQUENCE CHARACTERISTICS: LENGTH: 127 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...127 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:598 Met Phe Lys Lys Met Cys Leu Ser Leu Leu Met Ile 1 5 10 Val Gly Ala Lys Asp Leu Asp Phe Lys Leu Asp Tyr 25 Gly Lys Phe Met Gly Lys Met Thr Asp Ser Ser Leu 40 Ser Met Asn Asp Glu Pro Val Val Ile Lys Asn Leu 55 Gly Asn Ser Val Glu Ala Thr Lys Lys Val Glu Pro 70 75 Lys Phe Lys Lys Glu Lys Leu Phe Asp His Glu Leu Ser Gly Val Cys s15 Arg Ala Thr Gly 30 Leu Ser Ile Thr Ile Val Asn Arg Lys Phe Gly Asp Lys Tyr Ser Gin eutk PGT/US 9 6 0 9 1 2 2 IPEA/US 18 DEC1996 498 Gin Ile Phe-Tyr Arg Leu Asp Cys Lys Pro Asn Gln Leu Leu Glu Val 100 105 110 Lys lie Ile Thr Asp Lys Gly Glu Tyr Tyr His Lys Phe Ser Lys 115 120 125 INFORMATION FOR SEQ ID NO:599: SEQUENCE
CHARACTERISTICS:
LENGTH: 502 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...502 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:599 Met Thr Leu Lys Pro Tyr Pro Thr Lys Glu Thr Gly Leu Ala Ser Gin 1 5 10 Leu Ser Gly His Trp Phe Phe Gln Leu Ser Leu Phe Asn Lys Thr Asn 25 Phe Asn Pro Asn Lys Ile Trp Ile Pro Leu Glu Phe Asn Lys Arg Ser 40 Lys Ile Lys Phe Asp Lys Asp Leu Glu Ile Tyr Phe Asp Ser His Glu 55 Ser Phe Asn Ile Ser Lys Lys Tyr Leu Gln Glu Ile Asp Gln Glu Ser 70 75 Leu Lys Lys Ile Lys Gln Ser Lys Asp Phe Phe Ser Ile Gln Lys Ile 90 Glu Ser Lys His Asp Asn Asn Asp Ile Leu Gln Leu Glu Phe Phe Glu 100 105 110 Asn Asp Thr Ser Phe Leu Phe Ala Lys Gly Ser Phe Ala Glu Ile Leu 115 120 125 Glu Tyr Asn Met Gln Leu Lys Ile Asp Ser Leu Ile Thr Lys Glu Phe 130 135 140 Asn Lys Leu Leu Ala Ile Val Gin Asp Ser Pro Gin Asp Ser Tyr Gln 145 150 155 160 Leu Lys Ile Arg Val Arg His Asn Asn Lys Leu Pro Arg Glu Lys Tyr 165 170 175 Thr Glu His Glu Ile Lys Leu Glu Val Tyr Asp Cys Arg Lys Ser His 180 185 190 Asp His Asn Glu Pro Ile Ile Leu Ser Gln Gln Ser Thr Gly Phe Gin 195 200 205 Trp Ala Phe Asn Phe Met Phe Gly Phe Leu Tyr Asn Val Gly Ser His 210 215 220 Phe Ser Phe Asn His Asn Ile Ile Tyr Val Met Asp Glu Pro Ala Thr 225 230 235 240 His Leu Ser Val Pro Ala Arg Lys Glu Phe Arg Lys Phe Leu Lys Glu 245 250 255 Tyr Ala His Lys Asn His Val Thr Phe Val Leu Ala Thr His Asp Pro 260 265 270 Phe Leu Val Asp Thr Asp His Leu Asp Glu Ile Arg Ile Val Glu Lys 275 280 285 Glu Thr Glu Gly Ser Val Ile Lys Asn His Phe Asn Tyr Pro Leu Asn F 290 295 300 Asn Ala Ser Lys Asp Ser Asp Ala Leu Asp Lys Ile Lys Arg Ser Leu 7 <<f PCT/US 9 6 09 12 2 IPENAUS 18 DC E 996 499 305 310 .15 320 Gly Val Gly Gin His Val Phe His Asn Pro Gin Lys His Arg Ile Ile 325 330 335 Phe Val Glu Gly Ile Thr Asp Tyr Cys Tyr Leu Ser Ala Phe Lys Leu 340 345 350 Tyr Leu Arg Tyr Lys Glu Tyr Lys Asp Asn Pro Ile Pro Phe Thr Phe 355 360 365 Leu Pro Ile Ser Gly Leu Lys Asn Asp Ser Asn Asp Met Lys Glu Thr 370 375 380 Ile Glu Lys Leu Cys Glu Leu Asp Asn His Pro Ile Val Leu Thr Asp 385 390 395 400 Asp Asp Arg Lys Cys Val Phe Asn Gln Gin Ala Thr Ser Glu Arg Phe 405 410 415 Lys Arg Ala Asn Glu Glu Met His Asp Pro Ile Thr Ile Leu Gln Leu 420 425 430 Ser Asp Cys Asp Arg His Phe Lys Gin Ile Glu Asp Cys Phe Ser Ala 435 440 445 Asn Asp Arg Asn Lys Tyr Ala Lys Asn Lys Gln Met Glu Leu Ser Met 450 455 460 Ala Phe Lys Thr Arg Leu Leu Tyr Gly Gly Glu Asp Ala Ile Glu Lys 465 470 475 480 Gin Thr Lys Arg Asn Phe Leu Lys Leu Phe Lys Trp Ile Ala Trp Ala 485 490 495 Thr Asn Leu Ile Lys Asn 500 INFORMATION FOR SEQ ID NO:600: SEQUENCE CHARACTERISTICS: LENGTH: 42 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...42 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:600 Val Tyr Phe Phe Leu Ala Leu Ser Gly Glu Lys Val Leu Leu Pro Val 1 5 10 Ile Gly Gly Leu Glu Lys Asn Ala Leu Glu Ala Gly Leu Leu Lys Gly 25 Asp Arg Ile Leu Leu Ser Thr Ile Lys Lys INFORMATION FOR SEQ ID NO:601: SEQUENCE CHARACTERISTICS: LENGTH: 341 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein ,N (iii) HYPOTHETICAL: YES POT/US 9 6/ ugI IPEANS 18 DE- 6-996 500 (vi) ORI GINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc..feature LOCATION .341.
(xi) SEQUENCE DESCRIPTION: SEQ ID NO:601 1Met Glu Asn Phe Lys Leu Ile Asn Phe Phe Thr Gly Gly Asp Ile Phe Phe Ser Asn Asn As n 145 Lys Leu Ile Ile Glu 225 Lys Leu G lu Ile Thr 305 Glu Met Lys Pro Sen so Phe Glu Tyr Leu Pro 130 Leu Glu Lys Giu Arg 210 Glu Phe Phe Phe Phe 290 Ile Leu Leu l'hr Thr Giu T'yr His Sen Ile 115 Ser Giy Asn Ala Ile 195 Lys Sen Phe Ile ILeu 275 Ala Ser Giu Glu Asn Ala Phe Gin Ala Lys 100 As n Leu Leu Ala Leu 180 Leu Ser Pro Ile Asp Lys Thr Asp Lys Lys 340 Leu As n Arg Gly Thn Asp Thr Ser Ile Met 165 Giu Gin Val1 Lys Met 245 Giu Ala Thr Asn G iu 325 Ala Leu Gin Lys As n 70 Ile Ile Thr Pro His iso Phe Asn Cys Tyr Arg 230 Val1 Ile Leu His Glu 310 Sen Glu Val1 Ile 55 Thr Pro Asn Ile Met 135 Ser Ile Leu Phe Ilie 215 Leu Sen Giu Phe Asn 295 Thr Ala Ala Ser 40 Lys Ala Leu Leu Thr 120 Thr Asn Pro Gin Asn 200 Gin Leu Ile Ser Lys 280 Lys Gly Ser Leu 25 Leu Leu Asn Thr Asn 105 Lys Met Leu Ile Leu 185 Pro Ile Asn Leu Giy 265 Leu Giu Val1 Asp Tyr Pro Asp Pro Ile 90 Ser Pro Thn Asp Giu 170 Ala As n Lys Leu Ile 250 Leu Ala Phe Phe Phe 330 Thr Pro Ala Ile 75 Gin Asp Gin Tyr Lys 2.55 Leu Sen Ile Asp Phe 235 Asp His Gin Leu Lys 315 Ile Asn Glu Asp Sen Tyr Asp Leu Giu 140 Ile Sen Lys Leu Glu 220 Gly Asn His Lys Leu 300 Asp Arg Gin Thn His Asn' Ile Pro Ala Gin 125 Phe Ala Ile Glu Asn 205 Asn Trp Ang Thr Leu 285 Asn Ile His Asn Gly Al a Leu Ang Thr His 110 Phe Glu Gin Val1 Lys 190 Ala Thr Giy Val1 Lys 270 Gin Aia Ala Ser Asp Leu Val Lys Thr Gin Met Sen Ang Thr Asn 2.75 Giu Asn Pro Phe Lys 255 Met Ile Ile Leu Tyr 335 Ala Cys Asn Thr GiU Thr Thn Tyr Gin Tyr 160 Sen Leu Thn Leu Ile 240 Tyr Gin Gin Asn Phe 320 Sen INFORMATION FOR SEQ ID NO:602: SEQUENCE CHARACTERISTICS: LENGTH: 465 amino acids TYPE: amino acid TOPOLOGY: linear MOLECULE TYPE: protein POT/US 96 09 122 IPENUS 1a DEC 1996 501 (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION .465 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:602 Met Asp Phe Lys Lys Cys Pro Asn Phe Glu
I.
1 cys His Ile Asp Gin Lys Asp Tyr Asp 145 Giu Gin Ala Asp Glu 225 Lys Asn Val Tyr His 305 Asn Leu Tyr Lys Gly 385 Asn ?he det Leu Lys Ile Tyr Val Glu 130 Leu Ile Gly Leu Ile 210 Ile Leu Asp His Ser 290 Arg Asn Gly Ser Ile 370 Asn Asn Ser Gin Asp Ala Asn Leu Asn 115 Ala Ile Glu Leu Glu 195 Tyr Ile Pro Asn Ile 275 Trp Leu Ala Trp Leu 355 Glu Lys Phe Asn Lys Lys Asn Lys Ser 100 Phe Asn Asp Ile Glu 180 Asn Gln Pro Phe Glu 260 Leu Ile Ile Asr Thi 340 Arg Le Ar Gi Al 42 5 Leu Lys Gly Lys Ala Phe Phe Lys Arg Leu 165 Ile Gly Glu Ser Glu 245 Glu Ile Asp Asn Lys 325 Lys Ser a Gin Glu u Lys 405 Val Lys Asp Ile 70 Ser Glu Ala Glu Asn 150 Thr Gln Asn Val Ile 230 Ser Val Leu Lys Glu 310 Ile Glu Ala Lys Ile 390 Ala Leu I Pro 1 Val 55 Gin C Met Lys Asn Gly 135 Ile His Leu Glu Glu 215 Ser Ile Lys Glu Asp 295 Asn Lys Glu Leu Tyr 375 Lys Tyr Leu Lys 40 Ala Glu [le Arg fly 120 ?he Asp rhr Thr Ile 200 Arg Ser Asn Lys Gin 280 Asp Lys Gin Gin Leu 360 Tyr Pro Lys
I
Ile G 25 Asn P Thr A Pro L Ser A 9 Val T 105 Glu I Glu P Arg I Asn His 185 Val Thr Ala Asn Leu 265 Gin Asn Leu Phe Ser 345 Ser Glu Phe Glu Lys 425 0 lu ro sn eu rg 0 yr le rg Asn Ser 170 is Lys Lys Glu Glu 250 Glu Leu Ala Lys Phe 330 Ala Le Se Ly Ar 41 G1 Lys L Ile H Gin P Asn P 6 Pro T 75 Asp P Lys P Lys C Arg Arg C 155 Leu I Asn Glu Asp Tyr 235 Asn Phe Leu Asn Glu 315 Phe Ile 1 Glu r Val s Giu 395 g Tyr 0 u Gly ys Cys Ala P is ro ro 0 yr ro sp lu le Glu Lys Glu Tyr ly 220 Phe Thr Glu Ser Phe 300 Asn Asn Gin Glu Tyr 38( Il As Gl
I
Ser Lys G Asn Leu P Val Glu G Val Val L Ile Glu T 9 Asn Ser L 110 Ser Ser A 125 Thr Lys A Phe Phe I Glu Leu L 1 Thr His 1 190 Asp His 1 205 Gly Leu N Lys Leu Lys Leu Leu Ala 270 Ala Thr 285 Ala Trp His Leu Asn Gly Giu Asn 350 Ile Ala 365 Val Asn e Leu Arg p Lys Leu y Asn Giu 430 he L ly L he S lu S ys T 8 rp A ys G rg V rg T le L ys C Lys Leu Val yr Asn 255 Lys Asn Lys Ser Ser 335 Arg Gin Gly Asp Val 415 Arg eu eu er er hr 0 la lu al yr ys lu Lys Lys Arg Asn 240 Thr Glu Tyr Met Ala 320 Ile Asp Ala Asp Thr 400 Ser Gin Leu Ser Ala a 0 Ile Ile Gin Ala ARACKInctl 91MY707T IP S 18 DEC1996 502 Asn Ser Ser. Ala Asn Asn Asn Asn Pro Ile Lys Asn Thr Ile Glu Thr 435 440 445 Asn Thr Ser Asn Asn Ile Ile Gln Asn Asn Asp Asn Ile Ile Ile Gin 450 455 460 Ile 465 INFORMATION FOR SEQ ID NO:603: SEQUENCE CHARACTERISTICS: LENGTH: 193 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...193 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:603 Met Ala Leu Glu Val Val Leu Trp Asp Phe Asp Gly Val Ile Phe Asp 1 5 10 Ser Met His Leu Lys Tyr Glu Gly Phe Lys Ala Leu Phe Gln Lys His 25 Gly Asn Asp Ser Lys Glu Gly Leu Lys Gln Phe Glu Val Tyr His Tyr 40 Gin Ser Gly Gly Ile Ser Arg Asn Glu Lys Ile Gln Tyr Phe Tyr Asn 55 Glu Ile Leu Lys Thr Pro Ile Ala Gln Glu Glu Ile Asp Ala Leu Ala 70 75 Leu Glu Phe Gly Ala Ile Ile Glu Gln Lys Leu Phe Asp Arg Gly His 90 Leu Asn Ser Giu Val Met Ala Phe Ile Asp Lys His Tyr Gln Asn Tyr 100 105 110 Ile Phe His Ile Ala Ser Ala Ala Leu His Ser Glu Leu Gln Val Leu 115 120 125 Cys Glu Phe Leu Gly Ile Thr Lys Tyr Phe Lys Ser Val Giu Gly Ser 130 135 140 Pro Pro Asp Lys Pro Lys Ile Ile Ala Asn Ile Ile Gln Lys Tyr Ala 145 150 155 160 Tyr Asp Pro Ser Arg Met Leu Met Ile Ala Ile Ala Ser Met Ile Met 165 170 175 Lys Ala Leu Arg Leu Ile Lys Trp Arg Phe Trp Ala Ile Thr Ala Arg 180 185 190 Phe INFORMATION FOR SEQ ID NO:604: SEQUENCE CHARACTERISTICS: LENGTH: 141 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein PCT/U S A n I IPEANJS 8DEC1396f 503 (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...141 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:604 Met Leu Lys Lys Lys Ile Asp Leu His Lys Asp Ser Ile Arg Lys Leu 1 5 10 Phe Phe Tyr Tyr Phe Ile Pro Leu Val Phe Ser Met Ile Ser Leu Ser 25 Thr Tyr Ser Met Val Asp Asp Met Phe Val Gly Lys Lys Leu Gly Lys 40 Glu Ala Ile Ala Ala Val Asn Ile Ala Trp Pro Ile Phe Pro Gly Leu 55 Ile Ala Tyr Glu Leu Leu Phe Gly Phe Gly Ala Ala Ser Ile Val Gly 70 75 Tyr Phe Leu Gly Gln Asn Lys Thr His Arg Ala Arg Leu Val Phe Ser 85 90 Ser Val Phe Tyr Phe Val Ala Leu Ser Ala Phe Ile Leu Ser Met Ala 100 105 ll0 Leu Leu Pro Phe Ser Glu Asn Ile Ala Gln Phe Phe Gly Ser Asn Asp 115 120 125 Ala Leu Leu Asn Met Ser Asn Ala Ile Leu Lys Ser Phe 130 135 140 INFORMATION FOR SEQ ID NO:605: SEQUENCE
CHARACTERISTICS:
LENGTH: 159 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...159 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:605 Val Lys Cys Leu Leu Ile Lys Lys Ser Leu Leu Phe Ala Leu Lys Pro 1 5 10 Leu Pro Asp Leu Lys Thr Thr Thr Pro Ile Leu Ala Pro Met Ser Val 25 Val Ala Gly Arg Leu Unk Unk His Leu Val Gln His Tyr Leu Leu Ala 40 Leu Glu His Val Lys Gly Phe Met Gly Lys Gly Val Ile Leu Gly Gly 55 Leu Ser Gly Ala Gln Arg Ala Lys Ile Val Val Ile Gly Gly Gly Val 70 75 Val Gly Met Glu Ser Ala Lys Val Leu Unk Gln Met Gly Unk Lys Val 90 \Thr Ile Leu Glu Leu Asp Tyr Ala Lys Leu Gln Asn His Pro Tyr Tyr 100 105 110 PCT/US 96/0912?.
IPENUS 18 DEC 1996 His Gin Unk 145 Leu Tyr-Asp Leu Glu 115 Ala Leu Asn Gly Unk 130 Ser Gln Thr Pro Lys 150 Val Leu Ser Val Asn Glu Ala Asn Ile Ile 120 125 Val Gly Leu Val Gly Ala Val Leu Val Thr 135 140 Val Unk Leu Arg Arg His Leu Lys Tyr 155 INFORMATION FOR SEQ ID NO:606: SEQUENCE CHARACTERISTICS: LENGTH: 376 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...376 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:606 Met Leu Ala Lys Ile Val Phe Ser Ser Leu Val Ala Phe Gly Val Leu 1 Ser Glu Lys Lys Asp Thr Glu Pro Glu 145 Lys Met Leu Ser Gin 225 Lys Met Phe Ala Gln Leu Gln Leu Arg Gin Tyr 130 Arg Lys Gly Ala Asn 210 Leu Ala Ala Set Asn N Glu Leu Lys Glu Gly Ala 115 Ala Leu Thr Val SLeu 195 Leu Glu Thr Ile r Asn Val ;lu Asn Ile Asn Lys 100 Leu Tyr Ser Thr Phe 180 Ser Leu Arg Asn Asp 260 Leu 5 31u /al Asn Lys Lys Ile Lys Val Tyr Ala 165 Ser Tyr Ser Asn Thr 245 Lys Leu.
Gin I Ala Thr Glu I 70 Tyr Leu Asp Leu Tyr 150 Thr Leu Lys Arg Lys 230 Leu Ile Lys Phe Ala {is 55 Leu Lys Thr Asn Asn 135 Tyr Thr Asp Gin Lys 215 Phe Ile Asr As! 10 Gly Ser Phe F 25 Lys Glu Asp 40 Asp Phe Leu C Val Asp Tyr Lys Glu Lys 90 Ala Lys Ser 105 Pro Leu Tyr 120 Gin Glu Thr Pro Gln Val Lys Asp Lys 170 Glu Giu Gin 185 Ala Ile Glu 200 Glu Leu Asp Asp Ser Lys Phe Asn Ser 250 i Glu Lys Tyr 265 n Val Lys Asp 280 n Gln Lys Leu Phe Ala ;lu Arg 75 3lu Lys Lys Phe Lys 155 Ala Asn Glu Asn Ala 235 Glu Leu Asp Sei Asn G Leu L 4 Asp L Ala I Ala I Ala Lys I Thr 140 Thr Gin Lys Tyr Ile 220 Lys Arg Arg Val r Phe ilu ,ys ,eu ,ys Leu Tyr Leu 125 3ln Ser Ala Lys Ser 205 Asp Asp Leu Gly Glu 285 Al 1 Ile L Ala Val I Val Glu I Gly 110 Leu Glu Ser Leu Ala 190 Asn Tyr Ile Ala Tyr 270 a Leu i Gin -ys rg 'he Leu Lys Asp Pro Asp Ile Leu 175 Ser Asn Tyr Ala Phe 255 Gl Asi Ly Lys Lys Arg Leu Glu Leu Asn Lys Phe 160 Gin Arg SIle Leu SGin 240 e Ser u Ala n Thr s Gin 275 Thr Lys Asn Phe Thr As POT/US 96/09122 iPEAUS 505 290 295 300 Lys Leu Cys Leu Leu Val Leu Asp Ser Phe Asn Phe Asp Thr Gln Ser 305 310 315 320 Lys Lys Ser Ile Leu Lys Lys Thr Asn Glu Tyr Asn Ile Phe Val Asp 325 330 335 Ser Asp Pro Met Met Ser Asp Lys Thr Thr Met Gln Lys Glu His Tyr 340 345 350 Lys Ile Phe Asn Phe Phe Lys Thr Val Val Ser Ala Tyr Arg Asn Asn 355 360 365 Val Ala Lys Asn Asn Pro Phe Glu 370 375 INFORMATION FOR SEQ ID NO:607: SEQUENCE CHARACTERISTICS: LENGTH: 352 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...352 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:607 Met Asp Phe Val Gly Phe Glu Asp Leu Lys Cys Lys Asp Lys Glu Asn 1 5 10 Ser Gln Lys Val Phe Val Ile Arg Asn Asp Lys Leu Gly Asp Phe Ile 25 Leu Glu Ile Pro Ala Leu Ile Ala Leu Lys His Ala Phe Leu Glu Lys 40 Gly Val Glu Val Tyr Leu Gly Val Val Val Pro Ser Tyr Thr Thr Pro 55 Ile Ala Leu Glu Phe Pro Phe Ile Asp Glu Val Ile Ile Glu Asp Asn 70 75 His Leu Ala Thr Thr His Lys Asn Arg Ser Ile Asp Ala Leu Ile Phe 90 Leu Phe Ser Asn Phe Lys Asn Ala Lys Leu Ala Phe Ser Leu Arg Lys 100 105 110 Ser Ile Pro Tyr Ile Leu Ala Pro Lys Thr Lys Ile Tyr Ser Trp Leu 115 120 125 Tyr Gln Lys Arg Val Arg Gin Asn Arg Ser Leu Cys Leu Lys Thr Glu 130 135 140 Tyr Glu Tyr Asn Leu Asp Leu lie His Ala Phe Cys Lys Asp Tyr Asp 145 150 155 160 Leu Pro Asn Ala Gln Leu Lys Lys Ile Ala Trp Lys Leu Lys Asp Lys 165 170 175 Ser Lys Glu Arg Ser Ile Ile Ala Ser Lys Leu Asn Ala Asn Val Asp 180 185 190 Leu Leu Trp Ile Gly Val His Met His Ser Gly Gly Ser Ser Pro Val 195 200 205 Leu Pro Ala Ser His Phe Ile Glu Leu Ile Ala Ile Leu His Glu Lys 210 215 220 Leu Ser Cys Glu Ile Ile Leu Ile Cys Gly Pro Gly Glu Arg Lys Ala 225 230 235 240 Thr Glu Glu Leu Leu Lys Glu Val Pro Phe Ala His Leu Tyr Asp Thr 245 250 255 POT/US 96/09122 IPEA/US 18 DEC1996 506 Ser His Ser"Leu Val Asp Leu Ala Lys Leu Cys Ala Asn Leu Ser Val 260 265 270 Cys Ile Gly Asn Ala Ser Gly Pro Leu His Val Asn Ala Leu Phe Asp 275 280 285 Asn Gin Ser Ile Gly Phe Tyr Pro Asn Glu Leu Thr Ala Ser Ile Ala 290 295 300 Arg Trp Arg Pro Phe Asn Glu Gin Phe Leu Gly Ile Thr Pro Pro Asn 305 310 315 320 Gly Ser Asn Asp Met Gly Leu Ile Asp Ile Gin Lys Glu Ser Glu Lys 325 330 335 Ile Met Gly Phe Ile Thr Lys Asn Leu Ser His His Met Gin Glu Arg 340 345 350 INFORMATION FOR SEQ ID NO:608: SEQUENCE CHARACTERISTICS: LENGTH: 88 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...88 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:608 Val Gly Val Leu Ser Leu Lys Ile Glu Ala Ile Ser Asn Phe Tyr Gly 1 5 10 Leu Cys Val Leu Gly Val Leu Leu Ala Cys Phe Tyr Leu Leu Asp Ala 25 Tyr Tyr Leu Met Gln Glu Arg Leu Phe Arg Glu Gin Tyr Gin Trp Leu 40 Ile Lys Asn Arg Leu Lys Thr Asp Glu Arg Leu Phe Glu Val Phe Pro 55 Ile His Gin Thr Cys Gin Ser Thr Gin Phe Leu Ser Pro Cys Val Arg 70 75 Leu Val Phe Ser Pro Ile Gly Arg INFORMATION FOR SEQ ID NO:609: SEQUENCE CHARACTERISTICS: LENGTH: 86 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...86 V I Aiicjncr ouccr PCT/US 96/09 122 507 IPEA/US 18 DEC 1996 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:609 Met Ser Leu Gly Ala Val Val Ser Ser Leu Leu Cys His Lys Leu Glu 1 5 10 Gly Ala Ile Leu Asp Leu Arg Ala Tyr Arg Unk Unk Ala Tyr Tyr His 25 Glu Asn Lys Asp Thr Leu Leu Ile Lys Gly Lys Lys Arg Leu Leu Tyr 40 Asn Tyr Ile Lys Ala His Ile Unk Leu Asn Leu Leu Trp Thr Ile Arg 55 Asn Arg Thr Unk Ser Leu Gly Lys Phe Thr Gln Asn Pro Thr Glu Gin 70 75 Pro Pro Thr Asn Asn His INFORMATION FOR SEQ ID NO:610: SEQUENCE CHARACTERISTICS: LENGTH: 76 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...76 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:610 Met Lys Lys Thr Thr Leu Phe Val Leu Gly Leu Leu Phe Asn Ser Ser 1 5 10 Leu Ser Ala Val Asp Gly Ile Ser Gin Thr Glu Pro Ser Ser Leu Asn 25 Leu Ala Glu Asp Ser Leu Pro Leu Asn His Ser Asn Ala Gin Lys Leu 40 Ser Leu Lys Asn Ala Trp Asn Arg Val Leu Ser Asn His Glu Gly Leu 55 His Ala Gln Asn Thr Pro Leu Ser Glu Arg Val Lys 70 INFORMATION FOR SEQ ID NO:611: SEQUENCE CHARACTERISTICS: LENGTH: 98 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc feature PCi/US 9 6 9 122 IPEA/US 18 DEC1996 508 LOCATION 1...98 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:611 Val Lys Lys Val Glu Ser Met Asn Val Val Pro Phe Ile Asp Ile Met 1 5 10 Leu Val Leu Leu Val Ile Val Leu Thr Thr Ala Ser Phe Val Gin Thr 25 Ser Lys Leu Pro Ile Ser Ile Pro Gin Val Asp Lys Asp Ser Thr Asp 40 Ser Lys Asp Val Leu Asp Lys Lys Gin Val Thr Ile Ala Ile Ser Asn 55 Lys Gly Ser Phe Tyr Phe Asp Asp Lys Glu Ile Ser Phe Glu Asn Leu 70 75 Lys His Lys Val Ser Thr Leu Ala Lys Asp Thr Pro Ile Val Phe Ala 90 Arg Arg INFORMATION FOR SEQ ID NO:612: SEQUENCE CHARACTERISTICS: LENGTH: 162 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...162 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:612 Met Gly Ser Tyr Thr Phe Pro Leu Ile Leu Lys Pro Ile Phe Ile Asn 1 5 10 Lys Val Pro Val Thr Ile Asp Phe Tyr Ala Asn Ala Asn Tyr Phe Leu 25 Ile Tyr Gly Ala Leu Ala Asn Ala Val Val Gly Ser Ile Asn Ala Leu 40 Asn Asp Giu Ile Arg Phe Lys Arg Asn Ala Gin Ile Glu Glu Ala Glu 55 Leu Gly Thr Asp Gly Ile Lys Ile Lys Pro Ile Ala Leu Tyr Asn Pro 70 75 Ser Glu Gly Tyr Leu Asn Tyr Ala Leu Ser Ser Val Phe Ile Phe Ile 90 Leu His Gln Val Met Leu Ile Ala Ser Ser Met Phe Thr Ser Ser Arg 100 105 110 Arg Leu Glu Leu Ala Leu Leu Asp Lys Lys Gln Ile Ala Leu Arg Leu 115 120 125 Cys Ala Arg Leu Leu Val Phe Met Gly Ala Phe Ser Val Phe Val Leu 130 135 140 Trp Tyr Phe Gly Ala Leu Phe Ser Phe Tyr Gly Ile Glu Arg His Gly 145 150 155 160 Ser Ala INFORMATION FOR SEQ ID NO:613: PCTIUS 19122 IPEA/MS 18 DEC 1996 509 SEQUENCE CHARACTERISTICS: LENGTH: 58 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...58 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:613 Val Ile Met Thr Lys Leu Asp Gly Thr Ser Lys Gly Gly Ala Ile Leu 1 5 10 Unk Val Leu Tyr Glu Leu Lys Leu Pro Ile Leu Tyr Leu Gly Met Gly 25 Glu Lys Glu Asp Asp Leu Ile Ala Phe Asp Glu Glu Arg Phe Ile Glu 40 Asp Leu Val Asp Ala Val Phe Val Glu Gin INFORMATION FOR SEQ ID NO:614: SEQUENCE CHARACTERISTICS: LENGTH: 66 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...66 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:614 Val Cys Gly Ala His Gly Lys Ser Ser Ile Thr Unk Met Leu Ser Ala 1 5 10 Ile Cys Pro Ala Phe Gly Unk Ile Ile Gly Arg His Ser Lys Glu Phe 25 Asp Ser Asn Val Unk GIu Ser Ala Asp Met Ser Leu Val Phe GIu Unk 40 Asp Glu Ser Asp Ser Ser Phe Phe Ile Phe Gln Pro Phe Leu Arg Asp 55 Cys Ala INFORMATION FOR SEQ ID NO:615: SEQUENCE CHARACTERISTICS: N LENGTH: 116 amino acids POT/US 96/09 122 IPEAUS 18 DEC1996 510 TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...116 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:615 Met Ala Ile Ala Ile Lys Asp Leu Leu Ser Ala Tyr Lys Val Val Leu 1 5 10 Pro Leu Asp Lys Ile Ser Met Pro Ser Ser Ala Asp Leu Lys Leu Thr 25 Leu Gin Phe Leu Lys Asn Thr Ala Pro Leu Phe Ser Val Gln Gly Ser 40 Val Asn Leu Gln Glu Gly Thr Phe Ser Leu Tyr Asn Ile Pro Leu Tyr 55 Thr Gin Ser Ala Gin Ile Asn Leu Asp Ile Ala Gin Glu Tyr Gln Tyr 70 75 Ile Tyr Ile Asp Thr Ile His Thr Arg Tyr Ala Asn Met Unk Asp Leu 90 Asp Ala Lys Ile Ala Leu Asp Leu Gly Gin Lys Asn Leu Ser Unk Unk 100 105 110 Unk Leu Gly Pro 115 INFORMATION FOR SEQ ID NO:615: SEQUENCE CHARACTERISTICS: LENGTH: 116 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc.feature LOCATION 1...116 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:615 Met Ala Ile Ala Ile Lys Asp Leu Leu Ser Ala Tyr Lys Val Val Leu 1 5 10 Pro Leu Asp Lys Ile Ser Met Pro Ser Ser Ala Asp Leu Lys Leu Thr 25 Leu Gin Phe Leu Lys Asn Thr Ala Pro Leu Phe Ser Val Gin Gly Ser 40 Val Asn Leu Gln Glu Gly Thr Phe Ser Leu Tyr Asn Ile Pro Leu Tyr 55 Thr Gln Ser Ala Gin Ile Asn Leu Asp Ile Ala Gin Glu Tyr Gin Tyr 70 75 le Tyr Ile Asp Thr Ile His Thr Arg Tyr Ala Asn Met Unk Asp Leu PCT/US 9 6 0 122 IPEA/UJS 1 Dc s39 511 90 Asp Ala Lys"Ile Ala Leu Asp Leu Gly Gin Lys Asn Leu Ser Unk Unk 100 105 110 Unk Leu Gly Pro 115 INFORMATION FOR SEQ ID NO:616: SEQUENCE CHARACTERISTICS: LENGTH: 82 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...82 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:616 Met Pro Asp Asn Leu His Leu His Thr Leu Leu Unk Lys Phe Leu Gin 1 5 10 Gin Arg Ser Phe Asn Tyr Pro Asn Pro Leu Cys Ala Phe Ile Leu Ile 25 Leu Cys Asn Leu Pro Phe Ile Leu Ile Ser Val Leu Phe Arg Leu Asp 40 Ala Tyr Ala Leu Ile Val Ile Ser Leu Val Phe Ile Unk Cys Tyr Leu 55 Ile Gly Unk Ala Tyr Leu Asn Arg Gin Val Cys Ala Leu Glu Lys Arg 70 75 Ala Phe INFORMATION FOR SEQ ID NO:616: SEQUENCE CHARACTERISTICS: LENGTH: 82 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...82 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:616 Met Pro Asp Asn Leu His Leu His Thr Leu Leu Unk Lys Phe Leu Gin 1 5 10 Gin Arg Ser Phe Asn Tyr Pro Asn Pro Leu Cys Ala Phe Ile Leu Ile 25 POT/US 96/0q122 IPENJS 18 DEC1996 512 Leu Cys Asn Leu Pro Phe Ile Leu Ile Ser Val Leu Phe Arg Leu Asp 40 Ala Tyr Ala Leu Ile Val Ile Ser Leu Val Phe Ile Unk Cys Tyr Leu 55 Ile Gly Unk Ala Tyr Leu Asn Arg Gln Val Cys Ala Leu Glu Lys Arg 70 75 Ala Phe INFORMATION FOR SEQ ID NO:617: SEQUENCE CHARACTERISTICS: LENGTH: 77 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...77 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:617 Val Asn Glu Leu Lys Asn Ser Lys Gin Val Leu Gly Asn Gly Lys Ala 1 5 10 Asp Leu Ser Asn Glu Asn Thr Lys Val Arg Gin Thr Lys Thr Asn Leu 25 Thr Glu Lys Asn Gln Arg Leu Thr Thr Glu Lys Thr Glu Leu Asn Asn 40 Lys Ile Thr Gly Leu Ala Thr Glu Lys Glu Arg Leu Ala Ala Asp Lys 55 Glu Asn Leu Thr Lys Glu Ser Arg Gln Arg Lys Pro Asn 70 INFORMATION FOR SEQ ID NO:618: .SEQUENCE CHARACTERISTICS: LENGTH: 176 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...176 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:618 Met Asp Leu Gin Gin Ile Asp Glu Leu Glu Asn Lys Phe Glu Glu Gin "1 5 10 Plu Glu Gin Ala Gin Asp Thr Pro Leu Lys Gin Glu Pro Ser Thr Lys PCTUS 96/0912 1PEAUS 180 EC 1996 Glu Val Lys Ile Pro Lys Lys Arg Gly Arg Lys Lys Glu Lys Arg Lys Asn Thr Leu 145 Ala Asp s0 Giu Ser Asn Lys His 130 Giu As n Lys Leu Thr Thr Giu 115 Lys Gin Ile Lys Asn Phe Gin 100 Lys Ile Giu Leu Lys Giu Ile Giu Giy Ile Ile Ala 165 Ala Phe Ile Lys Met Pro Leu Aia 170 Phe Gly Arg Gin Asn Leu Val1 155 Lys Ser Ser His Leu Leu Lys 140 Giu Ile Ser Pro Phe Leu Giu Asn.
125 Phe Lys Ser INFORMATION FOR SEQ ID NO:6i9: SEQUENCE CHARACTERISTICS: LENGTH: 144 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .144 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:6i9 Met Glu Pro Lys Asp Asp Thr Lys Val1 Gly Gin Phe Lys Ala Phe Leu Gin Ser 130 Cys Tyr Lys Ser Asp Vai Leu Ala Leu Leu Giu Leu Glu Ser 100 Thr Ile 115 Giu Arg Gly Ile Gly Ile Ser Arg Leu Leu Ser Val Asp Val Phe Asp Ile Lys Lys Ile Asp Ile Giu Asp 70 Giy G lu Asp Arg Leu Val1 Val1 55 Arg Glu Phe Ile 0 ly 135 Asp Val1 40 Tyr Asp Arg Giu G ly 120 Giy 10 Val1 Asn Arg Arg Ala 90 Ile Arg dly Trp Leu Leu Phe 75 Leu Lys Arg Lys Thr Lys Leu Gly Ile Arg Lys Asn 140 Lys Asp Gin Ala Val1 Ala Asn 125 Ser Asn Glu Lys Lys Gly Asn 110 Phe Asp Ile Thr Ala Gly Met Lys Leu Arg Trp Leu Ala Gin Val Arg Gin Giu Asn Leu INFORMATION FOR SEQ ID NO:620: SEQUENCE CHARACTERISTICS: LENGTH: 90 amino acids PCT/US 9 6 09122 IPM S 180EC1996 514 TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...90 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:620 Met Glu Ile Gin Gln Thr His Arg Lys Ile Asn Arg Pro Leu Val Ser 1 5 10 Leu Val Leu Ala Gly Ala Leu Ile Ser Ala Ile Pro Gln Glu Ser His 25 Ala Ala Phe Phe Thr Thr Val Ile Ile Pro Ala Ile Val Gly Gly Ile 40 Ala Thr Gly Thr Ala Val Gly Thr Val Ser Gly Leu Leu Ser Trp Gly 55 Leu Lys Gln Ala Glu Glu Ala Asn Lys Thr Pro Asp Lys Pro Asp Lys 70 75 Val Trp Arg Ile Gln Ala Gly Lys Gly Leu INFORMATION FOR SEQ ID NO:621: SEQUENCE CHARACTERISTICS: LENGTH: 268 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori
FEATURE:
NAME/KEY: misc_feature LOCATION 1...268 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:621 Met Ser Glu Lys Glu Arg Leu Asn Giu Val lle Leu Glu Glu Glu Asn 1 5 10 Asn Gly Ser Gly Thr Lys Lys Val Phe Leu Ile Val Ala Ile Ala Ile 25 Ile Ile Leu Ala Val Leu Leu Met Val Phe Trp Lys Ser Thr Arg Val 40 Ala Pro Lys GIu Thr Phe Leu Gln Thr Asp Ser Gly Met Gln Lys Ile 55 Gly Asn Thr Lys Asp Glu Lys Lys Asp Asp Glu Phe Glu Ser Leu Asn 70 75 Met Asp Ser Pro Lys Gln Glu Asp Lys Leu Asp Lys Val Val Asp Asn 90 Ile Lys Lys Gln Glu Ser Glu Asn Ser Met Pro Ile Gln Thr Asp Gin 100 105 110 \Ala Gln Met Glu Met Lys Thr Thr Glu Glu Lys Gln Glu Ser Gln Lys PCT/US 96/09 122 IPENUS 18 DEC1996 115- 120 13 Glu Leu Lys Ala Val Glu Pro Ile Pro Met Ser Thr Gin Lys Glu Ser Val Asp Lys Lys 195 His Lys Lys Met Ala Lys Val 180 Thr Thr Ile Ser Thr 260 Lys 155 Ala Glu Tyr Gin Lys 235 His Val 140 Lys Lys Val Leu Glu 220 Arg Ala Arg Val Ala 175 Lys Gly Gin Ile Val 255 INFORMATION FOR SEQ ID NO:622: SEQUENCE CHARACTERISTICS: LENGTH: 171 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...171 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:622 Val Glu Tyr Tyr Ala Phe Asn Phe Ser Val Leu Asp Phe Val Leu Met 1 Gly Ile Lys Leu Glu Ala Ile Leu Thr 145 Lys Lys Asp Leu Pro Ile His Lys 130 Ser Ala Glu Gin Ala Thr Lys Asp 115 Asp His Thr Ala Gly Arg Ser Asp 100 Pro Lys Asn 5 His Thr Ile Ser Ala Glu Asn Lys Leu Leu Ser Asn Leu 70 Leu Met Leu Leu Ser 150 Asn Val Asp 55 Leu Asp Lys Val Phe 135 Ala Leu Leu 40 Leu Gin Leu Lys Ala 120 Leu Leu Phe 25 Glu Ser Arg Lys Arg 105 Arg Gin Tyr 10 Ala Met Arg Leu Gly Gly Thr Pro 75 Asn Gin 90 Glu Leu His Ser Ala Ser Asp Thr 155 Pro Asp Gin Leu Ala Ser Thr Thr 140 Pro Lys Leu Arg Leu Leu Val His 125 Pro Leu Ala Lys His Glu Ser Leu Gin Met Val Leu Leu Asp Phe Phe Asp Leu Val Asn 110 Val Val Met Ile Ala Met Unk Ala Ile 160 Trp His Asp Asp Lys 165 Leu Val Val Tyr Ala Leu 170 PCT/US 91/0 IPENUS18 DEC199 516 INFORMATION FOR SEQ ID NO:623: SEQUENCE CHARACTERISTICS: LENGTH: 102 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...102 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:623 Met Met Ala His Ser Leu Ile Leu Val Ser Lys Thr Ser Leu Ser Asn 1 5 10 Leu Leu Ile Phe Val Val Gln Pro Asp Gly Lys Leu Ser Met Thr Asp 25 Ala Ala Ile Asp Pro Asn Met Thr Asn Ser Gly Leu Arg Trp Tyr Arg 40 Val Asn Glu Ile Ala Glu Lys Phe Lys Leu Ile Lys Asp Lys Ala Leu 55 Val Thr Val Ile Asn Lys Gly Tyr Gly Lys Asn Pro Leu Thr Lys Asn 70 75 Tyr Asn Ile Lys Asn Tyr Gly Glu Leu Glu Arg Val Ile Lys Lys Leu 90 Pro Leu Val Arg Asp Lys 100 INFORMATION FOR SEQ ID NO:624: SEQUENCE CHARACTERISTICS: LENGTH: 116 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION 1...116 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:624 Leu Lys Val Thr Asn Pro His Leu Leu Val Val Ile Gln Asp Leu Asn 1 5 10 Ala Arg Ile Ala Leu Met Lys Leu Leu Phe Gin Asn Val Lys Ser Ala 25 Asn Lys Glu Leu Val Phe Cys Asn Lys Glu Lys Arg Leu Ile Arg Ser 40 Phe Asp Ala Gin Lys Glu Tyr Gly Ile Thr Pro Val Glu Asn Ile Leu 55 Ser Val Leu Asp Thr Ala Met Asn Pro Asn Ser Ala Leu Val Ile Asp PCT/US 96/09122 IPE US 18 DEC T996 517 70 75 Asn Leu Asn Glu Ala Lys Glu Leu His Asp Lys Val Gly Ala Glu Lys 90 Leu Lys Ser Phe Leu Glu Lys Ala Unk Arg Gln Arg Ala Val Leu Arg 100 105 110 His Phe Cys Ala 115 INFORMATION FOR SEQ ID NO:624: SEQUENCE CHARACTERISTICS: LENGTH: 116 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...116 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:624 Leu Lys Val Thr Asn Pro His Leu Leu Val Val Ile Gln Asp Leu Asn 1 5 10 Ala Arg Ile Ala Leu Met Lys Leu Leu Phe Gln Asn Val Lys Ser Ala 25 Asn Lys Glu Leu Val Phe Cys Asn Lys Glu Lys Arg Leu Ile Arg Ser 40 Phe Asp Ala Gln Lys Glu Tyr Gly Ile Thr Pro Val Glu Asn Ile Leu 55 Ser Val Leu Asp Thr Ala Met Asn Pro Asn Ser Ala Leu Val Ile Asp 70 75 Asn Leu Asn Glu Ala Lys Glu Leu His Asp Lys Val Gly Ala Glu Lys 90 Leu Lys Ser Phe Leu Glu Lys Ala Unk Arg Gln Arg Ala Val Leu Arg 100 105 110 His Phe Cys Ala 115 INFORMATION FOR SEQ ID NO:625: SEQUENCE CHARACTERISTICS: LENGTH: 237 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...237 PC7"? 96/09122 IPEAUS 18 DE C 1996 518 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:625 Val Leu Asn Glu Glu Gin Asn Ser Leu Glu Glu Lys Gly Gly Glu Asn 1 5 10 Lys Asn Glu Lys Glu Thr Pro Leu Lys Gly Ile His Ser Lys Ile Pro 25 Ser Leu Lys Gln Ala Leu Glu Gln Thr Ile Ser Lys Ile Lys Ser Ser 40 Lys Glu Phe Phe Lys Gln Leu Leu His Asn Lys Lys Lys Leu Tyr Ile 55 Ala Leu Gly Ile Leu Leu Ser Leu Ile Ala Leu Ile Val Ala Leu Ser 70 75 Leu Leu Leu Gly His Lys Lys Glu Asn Lys Gln Thr Ser Leu Gln Thr 90 Asn Thr Ala Thr Thr Asn Asn Glu Thr Pro Asn Asp Thr Asn Asn Ala 100 105 110 Glu Ala Glu Gly Gln Ile Glu Asn Leu Asp Leu Pro Asp Leu Ile Gly 115 120 125 Lys Asp Ser Leu Lys Arg Asn Asp Glu Ser Gln Val Asp Ala Met Met 130 135 140 Gin Lys Ala Ser Leu Leu Tyr Glu Gln Gly Gln Lys Asp Glu Ala Leu 145 150 155 160 His Leu Phe Asp Lys Ile Ala Ser Phe Ser Gln Gly Ile Ala Ser His 165 170 175 Asn Leu Gly Val Ile Lys Phe Lys GIu Lys Asp Phe Asn Gly Ala Leu 180 185 190 Asp Leu Phe Asp Ser Ser Ile Ala Ser Lys Glu Asn Ala Ser Val Ser 195 200 205 Ala Ile Asp Ala Leu Val Thr Ala Tyr His Leu Gln Asp Ala Asp Leu 210 215 220 Tyr Tyr His Tyr Leu Lys Ile Val Lys Arg His Phe Val 225 230 235 INFORMATION FOR SEQ ID NO:626: SEQUENCE CHARACTERISTICS: LENGTH: 198 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...198 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:626 Met Lys Glu Ser Phe Tyr Ile Glu Gly Met Thr Cys Thr Ala Cys Ser 1 5 10 Ser Gly Ile Glu Arg Ser Leu Gly Arg Lys Ser Phe Val Lys Lys Ile 25 Glu Val Ser Leu Leu Asn Lys Ser Ala Asn Ile Glu Phe Asn Glu Asn 40 Glu Thr Asn Leu Asp Glu Ile Phe Lys Leu Ile Glu Lys Leu Gly Tyr 55 Ser Pro Lys Lys Thr Leu Ala Glu Glu Lys Lys Glu Phe Phe Ser Pro 70 75 ,Asn Val Lys Leu Ala Leu Ala Val Ile Phe Thr Leu Phe Val Val Tyr P&US96/Oq 122 Leu Leu Ile Gly 145 Ala Trp Ile Met Ile 115 Ala Lys Gly Ile Lys 195 Gly 100 Asn Leu Ala Thr Pro 180 Ala Ala His Ile Leu Ser 165 Ile Cys Met His Val1 Trp 150 Ala Ile Ala Leu Ser Met 135 His Ala Ile 90 Ser Leu Gly Pro Ser 170 Ser Leu Asn Arg Asn 155 Ala Gly Leu Ala Asp 140 Met Cys Leu Pro Cys 125 Phe Ser dly Met Glu 110 Leu Tyr Ser Asn Gly 190 Ser Gin Ile Leu Cys 175 Ile.
INFORMATION FOR SEQ ID NO:626: SEQUENCE CHARACTERISTICS: LENGTH: 198 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .198 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:626 Met Lys Glu Ser Phe Tyr Ile Giu Gly Met Thr Cys Thr Ala 1 Ser Glu Giu Ser Asri Leu Leu Ile Gly 145 Ala Trp Gly Val1 Thr Pro Val1 Sen Thr Gly 130 Phe Ile Phe Ile Ser Asn Lys Lys Met Ile 115 Ala Lys Gly Ile 5 Arg Leu Asp Thr Ala Ala His Ile Leu Ser 165 Ile Ser Asn Giu Leu 70 Leu Met His Val1 Trp 150 Ala Ile Leu Lys Ile 55 Ala Ala Leu Sen Met 135 His Ala Ile dly Sen 40 Phe Giu Val Ser Asn 120 His Arg Leu Pro Arg Ala Lys Giu Ile Pro 105 Phe Leu Gin Ile Ile 185 10 Lys As n Leu Lys Phe 90 Sen Leu Gly Pro Ser 170 Ser Se r Ile Ile Lys 75 Thr Leu Asn Arg Asn 155 Ala Gly Phe C iu Glu Glu Leu Leu Ala Asp 140 Met Cys Leu Val1 Phe Lys Phe Phe Pro Cys 125 Phe Ser Gly Met Lys Asn Leu Phe Val1 Giu 110 Leu Tyr Ser Asn Gly 190 Cys Lys Glu dly Ser Val1 Ser Gin Ile Leu Cys 175 Ile Ser Ile Asn Tyr Pro Tyr Leu Leu Gin Ile 160 Ile Ile 180 Ile Leu Lys Ala Cys Ala PG6iJS 6 09 i 2.
IPEA/UJS 18 DEC1996 520 INFORMATION FOR SEQ ID NO:627: SEQUENCE CHARACTERISTICS: LENGTH: 225 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...225 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:627 Met Asn Thr Ser Leu Leu Thr Gln Ala Gln Val Leu Ser Ser Lys Glu 1 5 10 Asn Gln Ile His Arg Leu Leu Leu Glu Leu Leu Glu Glu Ala Lys Leu 25 His Phe Glu Pro Lys Leu Tyr Ile Ile Asn Ala Pro Tyr Met Asn Ala 40 Phe Ala Ser Gly Trp Asp Glu Ser Asn Ser Leu Ile Ala Leu Thr Ser 55 Ala Leu Ile Glu Arg Leu Asp Arg Asp Glu Leu Lys Ala Val Ile Ala 70 75 His Glu Leu Ser His Ile Arg His Asn Asp Ile Arg Leu Thr Met Cys 90 Val Gly Ile Leu Ser Asn Ile Met Leu Leu Val Ala Asn Phe Ser Val 100 105 110 Tyr Phe Phe Met Gly Asn Arg Lys Asn Ser Gly Ala Asn Leu Ala Arg 115 120 125 Met Ile Leu Trp Val Leu Gln Ile Ile Leu Pro Phe Leu Thr Leu Leu 130 135 140 Leu Gln Met Tyr Leu Ser Arg Thr Arg Glu Tyr Met Ala Asp Ser Gly 145 150 155 160 Ala Ala Phe Leu Met His Asp Asn Lys Pro Met Ile Arg Ala Leu Gin 165 170 175 Lys Ile Ser Asn Asp Tyr Thr Asn Asn Asp Tyr Lys Glu Ile Asp Lys 180 185 190 Asn Ser Thr Arg Ser Ala Ala Tyr Leu Phe Asn Ala Glu Met Phe Ser 195 200 205 Thr His Pro Ser Ile Lys Asn Arg Ile Gln Ser Leu Arg Lys Arg Val 210 215 220 Ile 225 INFORMATION FOR SEQ ID NO:628: SEQUENCE CHARACTERISTICS: LENGTH: 85 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES R(vi) ORIGINAL SOURCE: 7/ ORGANISM: Helicobacter pylori TU? 96/09122 S 18 DEC 1996 521 (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...85 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:628 Val Gly Ile Val Pro Asp Asn Leu Trp Lys Leu Lys Arg Phe Asn Gin 1 5 10 Asp Trp Arg Val Gly Asp Thr Leu Ile Thr Ala Ile Gly Gln Gly Ser 25 Phe Leu Ala Thr Pro Leu Gin Val Leu Ala Tyr Thr Gly Leu Ile Ala 40 Thr Gly Lys Leu Ala Thr Pro His Phe Ala Ile His Asn Gin Gin Pro 55 Leu Lys Asp Pro Leu Asn Arg Phe Ser Lys Lys Glu Ala Pro Ser Leu 70 75 Ala Arg Gly His Val INFORMATION FOR SEQ ID NO:628: SEQUENCE CHARACTERISTICS: LENGTH: 85 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...85 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:628 Val Gly Ile Val Pro Asp Asn Leu Trp Lys Leu Lys Arg Phe Asn Gin 1 5 10 Asp Trp Arg Val Gly Asp Thr Leu Ile Thr Ala Ile Gly Gin Gly Ser 25 Phe Leu Ala Thr Pro Leu Gin Val Leu Ala Tyr Thr Gly Leu Ile Ala 40 Thr Gly Lys Leu Ala Thr Pro His Phe Ala Ile His Asn Gin Gin Pro 55 Leu Lys Asp Pro Leu Asn Arg Phe Ser Lys Lys Glu Ala Pro Ser Leu 70 75 Ala Arg Gly His Val INFORMATION FOR SEQ ID NO:629: SEQUENCE CHARACTERISTICS: LENGTH: 496 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES PCT/US 9 6 09 122 IPENUS 18 DEC1996 522 (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...496 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:629 Met Phe Asn Ile Lys Arg Thr Phe Leu Ile Thr Ile 1 Leu Ile Val Pro Asn Leu Lys Ile Val Leu Thr Asn Ile Gly Ala Ser Ala Leu Ser Thr Lys Tyr Leu Asn 100 Val Ala Thr Ala 115 Asn Phe Gly Trp 130 Asp Ser Val Leu 145 Gly Gly Val Glu Gly Ser Ile Thr 180 Ile Trp Leu Ile 195 Thr Ile Ala Met 210 Ala Asp Ala Ala 225 Ile Ile Ile Gly Tyr Ile Val Phe 260 Asp Ile Ser Asn 275 Phe Val Gly Gly 290 Tyr Ala Gly Phe 305 Gly Leu Ala Gly Asp Leu Val Leu 340 Ala Val Phe Ser 355 Leu Gin Val Ala 370 Ile Ile Met Arg 385 Ala Phe Ser Gly Asp Trp Phe Lys 420 5 Asn Tyr Lys Gly Pro Thr Ile Asn Asp Asp 165 Ala Gly Leu Val Gin 245 Gly Gly Thr Gly Ala 325 Asn Asn Gly Ile Ile 405 Asp Trp Gin Ser Ser 70 Leu Leu Gin Ala Asn 150 Asn Gin Lys Ala Leu 230 Gly Ile Ile Leu Tyr 310 Phe Tyr Val Ile Ser 390 Val Ser Leu Thr Phe 55 Gly Ala Gly Gly Leu 135 Leu Val Ala Glu Phe 215 Pro Ser Phe Gin Phe 295 Leu Gly Thr Gly Ser 375 Thr Phe Met Lys Val 40 Ala Lys Thr Pro Phe 120 Ile Ser Lys Ser Phe 200 Ala Ala Tyr Val Ile 280 Lys Tyr Leu Val Asn 360 Leu Val Prc Lys Ala 25 Tyr Asp Ser Ser Leu 105 Ala Asn Asn Gly Thr 185 Thr Ala Tyr Leu Phe 265 Asn Met Lys Asn SAsn 345 Asn Phe Val Ile Asn 10 lie Cys lie Ser Leu 90 Trp Leu Lys Lys Asn 170 Asn Ala Leu Gly Asp 250 Ile Ile Ala Ile Gin 330 Ser Ala Ala Val Ala 410 Ile Asp Met Leu Gly 75 Ala Gly Thr Asn Ile 155 Ile Ile Asn Glu Val 235 Phe Ser Gly Met Ser 315 Val Ile Pro Ile Lys 395 Val Leu Leu Leu Thr Gln Ala Ser Pro Ile 140 Gin Leu Thr Lys Ser 220 Val Val Phe Phe Val 300 Tyr Leu Leu Ser Phe 380 Pro Cys Ile Ile Pro Ile Gly Gly Ser Ala Ser 125 Asp Asn Leu Ala Leu 205 Val Asn Ser Met Glu 285 Ser Ser Phe Pro Leu 365 Met Leu Leu Trp 3er Ile ?ro Tyr /al Asn Trp 110 Ser Val Phe Gln Asp 190 Gln Val Leu Tyr Lys 270 Tyr Phe Ile Trp Ala 350 Leu Gin Ile Ile Phe Phe Val Ser Thr Ile Leu Ala Gly Ser Thr Ile 175 Gly Asn Lys Pro Leu 255 Leu Met Ile Tyr Ala 335 Val Gin Val Ala Val 415 Ile Phe Ser Tyr Ser Glu Val Ser Cys Met Lys 160 Ile Leu Asn Gly Asp 240 Ile Arg Arg Ala Phe 320 Leu Arg Gly Thr Gly 400 Leu Asn -0*RA -0 ic) O 7 425 430 Asn Leu Phe Ile Leu Val Leu Ala Ile Pro Ile Leu Leu Phe Gly Val POT/US 96/09122 IPENUS 18 DEC 1996 523 435- 440 445 Leu Ala Leu Leu Ala Phe Asn Leu Thr Ile Thr Pro Ser Val Ala Ile 450 455 460 Gin Asn Ile Asn Gin Gly Gly Leu Gly Ile Asp Ser Thr Ile Ala Ser 465 470 475 480 Leu Ile Thr Leu Phe Ile Leu Lys Gly Phe Ile Glu Thr Ile Ile Glu 485 490 495 INFORMATION FOR SEQ ID NO:630: SEQUENCE CHARACTERISTICS: LENGTH: 142 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc feature LOCATION 1...142 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:630 Met Ala Phe Trp Gln Ala Ile Arg Trp Trp Ile Leu Lys Leu Pro Phe 1 5 10 Met Met Gly Ala Thr Met Met Trp Ile Leu Ser Glu Met Ala Phe Lys 25 Ile Ala Gly Unk Met Ala Phe Lys Glu Ala Ser Arg Ala Ala Asn Pro 40 Val Leu Leu Glu Pro Met Met Lys Val Glu Val Glu Val Pro Glu Glu 55 Tyr Met Gly Asp Val Ile Gly Asp Leu Asn Arg Arg Arg Gly Gin Ile 70 75 Asn Ser Met Asp Asp Arg Leu Gly Leu Lys Ile Val Asn Ala Phe Val 90 Pro Leu Val Glu Met Phe Gly Tyr Ser Thr Asp Leu Arg Ser Ala Thr 100 105 110 Gin Gly Arg Gly Thr Tyr Ser Met Glu Phe Asp His Tyr Gly Glu Val 115 120 125 Pro Ser Asn Ile Ala Lys Glu Ile Val Glu Lys Arg Lys Gly 130 135 140 INFORMATION FOR SEQ ID NO:631: SEQUENCE CHARACTERISTICS: LENGTH: 153 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori S(ix) FEATURE: NAME/KEY: misc_feature ~AA cnnJ PCT/US 9 6 09 122 IPEA/US 18 C 396 524 LOCATION 1...153 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:631 Met Gln Asn Leu Pro Gly Met Ala Arg Ala Ala Met Leu Thr Thr Ser 1 5 10 Ser Ala Pro Ala Pro Glu Gly Glu Gly Ala Phe Arg Ala Met Lys Met 25 Ala Ser Glu Met Ala Lys Val Glu Val Gly Tyr Val Asn Ala His Gly 40 Thr Ser Thr His Tyr Asn Asp Trp Tyr Glu Ser Ile Ala Leu Lys Asn 55 Val Leu Ala Leu Lys Lys Lys Ser Leu Leu Leu Ala Pro Leu Lys Gly 70 75 Arg Leu Gly Leu Leu Gly Cys Cys Gly Val Arg Ser Arg Tyr Ser Ile 90 Met Ala Met Unk Gln Gly Ile Leu Pro Pro Thr Ile Asn Gln Glu Thr 100 105 110 Pro Asp Pro Glu Cys Unk Leu Asp Tyr Ile Pro Asn Thr Ala Arg Glu 115 120 125 Lys Gln Val Asn Ala Val Met Ser Asn Ser Phe Gly Phe Gly Gly Thr 130 135 140 Asn Gly Val Val Ile Phe Lys Lys Ala 145 150 INFORMATION FOR SEQ ID NO:632: SEQUENCE CHARACTERISTICS: LENGTH: 343 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...343 (xi).SEQUENCE DESCRIPTION: SEQ ID NO:632 Met Gln Asn Leu Leu Ile Gln Ala Glu Asn Ala Ile Ala Leu Leu Phe 1 5 10 Leu Leu Asn Asp Lys Asn Leu Lys Gly Lys Ile Asp Leu Ile Tyr Ile 25 Asp Pro Pro Phe Ala Thr Asn Asn His Phe Thr Ile Thr Asn Gly Arg 40 Ala Thr Thr Ile Ser Asn Ser Lys Asn Gly Asp Ile Ala Tyr Ser Asp 55 Lys Val Val Gly Met Asp Phe Met Glu Phe Leu Lys Gln Arg Leu Val 70 75 Leu Leu Lys Glu Leu Leu Ser Glu Gln Gly Ser Ile Tyr Val His Thr 90 Asp Tyr Lys Ile Gly His Tyr Val Lys Val Met Leu Asp Glu Ile Phe 100 105 110 Gly Ile Gln Asn Phe Arg Asn Glu Ile Thr Arg Ile Lys Cys Asn Pro 115 120 125 Lys Asn Phe Lys Arg Ile Gly Tyr Gly Asn Ile Lys Asp Met Ile Leu 130 135 140 Phe Tyr Ser Lys Gly Lys Asn Pro Ile Phe Asn Glu Pro Lys Ile Pro PCT/US 9 6 09 122 IPENUS 18 DEC1996 525 145 150 155 160 Tyr Thr Pro Gln Asp Leu Glu Lys Arg Phe Pro Lys Ile Asp Lys Asp 165 170 175 Lys Arg Arg Tyr Thr Thr Val Pro Ile His Ala Pro Gly Glu Val Glu 180 185 190 Ser Gly Glu Cys Ser Lys Ala Phe Lys Gly Met Leu Pro Pro Lys Gly 195 200 205 Arg His Trp Arg Thr Asp Ile Ala Thr Leu Glu Arg Trp Asp Lys Glu 210 215 220 Gly Leu Ile Glu Tyr Ser Asn Asn Asn Asn Pro Arg Lys Lys Ile Tyr 225 230 235 240 Ala Leu Glu Gln Val Gly Lys Arg Val Gln Asp Ile Trp Glu Phe Lys 245 250 255 Asp Pro Gln Tyr Pro Ser Tyr Pro Thr Glu Lys Asn Ala Gln Leu Leu 260 265 270 Asp Leu Ile Ile Lys Thr Ser Ser Asn Lys Asp Ser Ile Val Leu Asp 275 280 285 Cys Phe Cys Gly Ser Gly Thr Thr Leu Lys Ser Ala Phe Leu Leu Gin 290 295 300 Arg Lys Phe Ile Gly Ile Asp Asn Ser Asp Leu Ala Ile Gln Ala Cys 305 310 315 320 Lys Asn Lys Leu Glu Thr Ile Thr Lys Asp Leu Phe Val Ser Gln Asn 325 330 335 Phe Tyr Asp Phe Leu Val Phe 340 INFORMATION FOR SEQ ID NO:632: SEQUENCE CHARACTERISTICS: LENGTH: 343 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION 1...343 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:632 Met Gln Asn Leu Leu Ile Gln Ala Glu Asn Ala Ile Ala Leu Leu Phe 1 5 10 Leu Leu Asn Asp Lys Asn Leu Lys Gly Lys Ile Asp Leu Ile Tyr Ile 25 Asp Pro Pro Phe Ala Thr Asn Asn His Phe Thr Ile Thr Asn Gly Arg 40 Ala Thr Thr Ile Ser Asn Ser Lys Asn Gly Asp Ile Ala Tyr Ser Asp 55 Lys Val Val Gly Met Asp Phe Met Glu Phe Leu Lys Gln Arg Leu Val 70 75 Leu Leu Lys Glu Leu Leu Ser Glu Gln Gly Ser Ile Tyr Val His Thr 90 Asp Tyr Lys Ile Gly His Tyr Val Lys Val Met Leu Asp Glu Ile Phe 100 105 110 Gly Ile Gln Asn Phe Arg Asn Glu Ile Thr Arg Ile Lys Cys Asn Pro 115 120 125 Lys Asn Phe Lys Arg Ile Gly Tyr Gly Asn Ile Lys Asp Met Ile Leu 130 135 140 'aumPmfl Pv;;T PCT/US 96/09122 IPEMJS 18 DEC1996 526 Phe Tyr Ser-Lys Gly Lys Asn Pro Ile Phe Asn Glu Pro Lys Ile Pro 145 150 155 160 Tyr Thr Pro Gln Asp Leu Glu Lys Arg Phe Pro Lys Ile Asp Lys Asp 165 170 175 Lys Arg Arg Tyr Thr Thr Val Pro Ile His Ala Pro Gly Glu Val Glu 180 185 190 Ser Gly Glu Cys Ser Lys Ala Phe Lys Gly Met Leu Pro Pro Lys Gly 195 200 205 Arg His Trp Arg Thr Asp Ile Ala Thr Leu Glu Arg Trp Asp Lys Glu 210 215 220 Gly Leu Ile Glu Tyr Ser Asn Asn Asn Asn Pro Arg Lys Lys Ile Tyr 225 230 235 240 Ala Leu Glu Gln Val Gly Lys Arg Val Gln Asp Ile Trp Glu Phe Lys 245 250 255 Asp Pro Gln Tyr Pro Ser Tyr Pro Thr Glu Lys Asn Ala Gln Leu Leu 260 265 270 Asp Leu Ile Ile Lys Thr Ser Ser Asn Lys Asp Ser Ile Val Leu Asp 275 280 285 Cys Phe Cys Gly Ser Gly Thr Thr Leu Lys Ser Ala Phe Leu Leu Gin 290 295 300 Arg Lys Phe Ile Gly Ile Asp Asn Ser Asp Leu Ala Ile Gln Ala Cys 305 310 315 320 Lys Asn Lys Leu Glu Thr Ile Thr Lys Asp Leu Phe Val Ser Gln Asn 325 330 335 Phe Tyr Asp Phe Leu Val Phe 340 INFORMATION FOR SEQ ID NO:633: SEQUENCE CHARACTERISTICS: LENGTH: 93 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...93 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:633 Met Ile Leu Lys Asn Leu Ile Leu Leu Phe Leu Ala Lys Arg Lys Leu 1 5 10 Ile Phe Ile Glu Ala Asn Phe Tyr Thr Ile Ser Gly Ser Lys Leu Asn 25 Glu Val Ala Arg Ser Tyr Gln Asp Leu Ala Leu Lys Phe Glu Ala Phe 40 Pro Asn Tyr Glu Phe Ile Trp Ile Thr Asp Gly Ile Gly Trp Leu Asp 55 Ala Lys Ser Lys Leu Gln Glu Ala Tyr Lys Ser Val Glu Ile Tyr Asn 70 75 Leu Ser Tyr Val Asn Asp Phe Ile Ser Lys Val Gln Lys INFORMATION FOR SEQ ID NO:634: SEQUENCE CHARACTERISTICS: w ft P, q I -?7,r 527 LENGTH: 176 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...176 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:634 Met Thr Ser Val Val Ile Lys Pro His Ala Tyr Gly Giu Gin Val Gin 1 5 10 Glu Ile Glu Glu Glu Ser Asp Ser Asp Tyr Glu Lys Asn Asn Asp Gin 25 Glu Ala Ile Asn Phe Gly Ile Ala Leu His Lys Gly Leu Glu Tyr Gin 40 Tyr Ala Tyr Asn Ile Pro Lys Gin Ser Val Leu Glu Tyr Leu Asn Tyr 55 His Tyr Gly Phe Tyr Gly Leu Asp Tyr Gin Ala Leu Glu Glu Ser Leu 70 75 Glu Leu Phe Glu Asn Asp Ala Gly Ile Gln Ala Leu Phe Lys Asn His 90 Ala Leu Lys Gly Glu Ala Ala Phe Leu Phe Gin Gly Val Val Ser Arg 100 105 110 Ile Asp Val Leu Leu Trp Asp Arg Gly Gin Asn Leu Tyr Val Leu Asp 115 120 125 Tyr Lys Ser Ser Gln Asn Tyr Gin Gin Ser His Lys Ala Gin Val Ser 130 135 140 His Tyr Ala Glu Phe Leu Arg Thr Gin Unk Pro His Phe Lys Ile Gin 145 150 155 160 Ala Gly Ile Ile Tyr Ala His Lys Arg Leu Leu Glu Lys Unk Trp Unk 165 170 175 INFORMATION FOR SEQ ID NO:634: SEQUENCE CHARACTERISTICS: LENGTH: 176 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...176 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:634 Met Thr Ser Val Val Ile Lys Pro His Ala Tyr Gly Glu Gin Val Gin 1 5 10 Glu Ile Glu Glu Glu Ser Asp Ser Asp Tyr Glu Lys Asn Asn Asp Gin 25 fAM6NOD S iT PCT/US 96/ 0 9122 IPEAUS 18 DEC1992 Glu Tyr His Glu Ala Ile Tyr His 145 Ala Ala Ala Tyr Leu Leu Asp Lys 130 Tyr Gly lie- Asn Tyr Asn Gly Phe Phe Glu Lys Gly 100 Val Leu 115 Ser Ser Ala Glu Ile Ile Phe Ile Tyr Asn Glu Leu Gin Phe Tyr 165 Gly Pro Gly 70 Asp Ala Trp Asn Leu 150 Ala Ile Lys 55 Leu Ala Ala Asp Tyr 135 Arg His Ala 40 Gin Asp Gly Phe Arg 120 Gin Thr Lys His Va 1 Gin Gin 90 Phe Gin Ser Unk Leu 170 528 Lys Gly Leu Glu Ala Leu 75 Ala Leu Gin Gly Asn Leu His Lys 140 Pro His 155 Leu Glu Leu Tyr Glu Phe Val Tyr 125 Ala Phe Lys Tyr Asn Ser Asn Ser Leu Val Ile Trp 175 Gin Tyr Leu His Arg Asp Ser Gin 160 Unk INFORMATION FOR SEQ ID NO:635: SEQUENCE CHARACTERISTICS: LENGTH: 88 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...88 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:635 Glu Ser Gln Leu Met Lys Leu Ala Ile Glu 5 10 Met Ile Ser Leu Pro Val Leu Leu Ala Gly 25 Val Ser Ile Phe Gln Ala Thr Thr Gln Ile 40 Phe Val Pro Lys Ile Leu Ala Val Ile Gly 55 Pro Trp Met Thr Asn Met Leu Leu Asp Tyr 70 75 Leu Ile Pro Lys Ile Ile Gly Met 1 Leu Leu Ser Met Lys Thr Tyr Lys Ile Leu Val Val Gly Asn Glu Met Thr Val Leu Ile Leu Thr Lys Thr Leu Thr Leu Leu Thr Ile INFORMATION FOR SEQ ID NO:636: SEQUENCE CHARACTERISTICS: LENGTH: 115 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES AMENDED Syl--T POT/US 96/09122 IPEA/US 1 8 DEC1996 529 (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...115 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:636 Met Lys Phe Phe Thr Arg Ile Thr Asp Ser Tyr Lys Lys Val Val Val 1 5 10 Thr Leu Gly Leu Val Val Thr Thr Asn Pro Leu Met Ala Val Thr Ser 25 Pro Ala Thr Gly Val Thr Glu Thr Lys Ser Leu Val Ile Gln Ile Ile 40 Ser Val Leu Ala Ile Val Gly Gly Cys Ala Leu Gly Val Lys Gly Ile 55 Ala Asp Ile Trp Lys Ile Ser Asp Asp Ile Lys Arg Gly Gin Ala Thr 70 75 Val Phe Ala Tyr Ala Gln Pro Ile Ala Met Leu Ala Val Ala Gly Gly 90 Ile Ile Tyr Leu Ser Thr Lys Phe Gly Phe Asn Ile Gly GIu Ser Gly 100 105 110 Gly Ala Ser 115 INFORMATION FOR SEQ ID NO:637: SEQUENCE CHARACTERISTICS: LENGTH: 260 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...260 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:637 Met Ser Glu Asp Leu Pro Phe Ala Ser Asp Ser Gln Phe Thr Tyr Asn 1 5 10 Gly Val Ser Ile Thr Arg Pro Thr Asn Glu Val Asn Asp Val Ile Ser 25 Gly Val Asn Ile Thr Leu Glu Gln Thr Thr Glu Pro Asn Lys Pro Ala 40 Ile Ile Ser Val Ser Arg Asp Asn Gln Ala Ile Ile Asp Ser Leu Lys 55 Glu Phe Val Lys Ala Tyr Asn Glu Leu Ile Pro Lys Leu Asp Glu Asp 70 75 Thr Arg Tyr Asp Ala Asp Thr Lys Ile Ala Gly Ile Phe Asn Gly Val 90 Gly Asp Ile Arg Ala Ile Arg Ser Ser Leu Asn Asn Val Phe Ser Tyr 100 105 110 Ser Val His Thr Asp Asn Gly Val Glu Ser Leu Met Lys Tyr Gly Leu 115 120 125 Ser Leu Asp Asp Lys Gly Val Met Ser Leu Asp GIu Ala Lys Leu Ser k 130 135 140 AMFPJfl~ ~'FFV i* 96 0 9 122 IpnuS 18 DEC 1996 Ser 145 Ser Phe Ala Leu Asn 225 Ala Ala Ala Asp Ser Lys Thr 210 Ile Asn Lys Leu Asn Ser Lys Lys Phe 180 Leu Lys 195 Lys Asp Met Ala Gin Lys Lys Asn 260 Pro Gly Val1 Giu Asn 215 Phe Ser Ala Arg Ala 185 Ser Gin Ala Gin 530 Gin Asp 155 Ile His Leu Ile Asp Arg Leu Leu 220 Asp Ser 235 Met Ile Phe Gin Asp Asp 205 Lys Gin Asp INFORMATION FOR SEQ ID NO:637: SEQUENCE CHARACTERISTICS: LENGTH: 260 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .260 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:637 Met Ser Giu Asp Leu Pro Phe Ala Sen Asp Ser Gin Phe Thr Tyr Asn is 1 Gly Gly Ile Giu Thr Gly Sen Sen Ser 145 Ser Phe Ala Val Sen Val Asn Ile Sen Phe Val Arg Tyr Asp Ile Val His 115 Leu Asp 130 Ala Leu Asp Ser Ser Lys Lys Leu 195 Ile Ile Val1 Lys Asp Arg 100 Thr Asp Asn Lys Phe 180 Lys 5 Thr Thr Ser Ala Ala Ala Asp Lys Ser Asp 165 Asn Ile Arg Leu Arg Tyr 70 Asp Ile Asn Gly Asn 150 Met Gin TIyr Pro Giu Asp 55 Asn Thr Arg Gly Val1 135 Pro Gly Val1 Giu Thr Gin 40 Asn Giu Lys Ser Val1 120 Met Lys Gly Ile Asp Asn 25 Thr Gin Leu Ile Ser 105 Giu Sen Ala Arg Ala 185 Sen Giu Thr Aia Ile Ala 90 Leu Ser Leu Thr Giu 170 As n Leu Val Giu Ile Pro 75 Gly Asn Leu Asp Gin 155 Ile Leu Asp A.sn Pro Ile Lys Ile Asn Met G lu 140 Asp His Ile Arg Asp Asn Asp Leu Phe Val1 Lys 125 Ala Phe Gin Asp Asp 205 Val1 Lys Ser Asp Asn Phe 110 Tyr Lys Phe Giu pGiy 190 Ala Ile Pro Leu Glu Gly Ser Gly Leu Tyr Gly 175 Gly Lys Ser Ala Lys Asp Val Tyr Leu Ser Gly 160 Ile Asn Sen 200 RA I
NK-
T 00 Leu Thr Lys Asp Lys Giu Asn Ala Gin Giu Leu Leu Lys Thr Arg Tyr amm!)FO SHEET1 ~NT QY AMFN"'~fl SH~ET1 PCTA' u9i22 IPEAUS 18 DEC1996 531 210 215 220 Asn Ile Met Ala Glu Arg Phe Ala Ala Tyr Asp Ser Gin Ile Ser Lys 225 230 235 240 Ala Asn Gin Lys Phe Asn Ser Val Gin Met Met Ile Asp Gin Ala Ala 245 250 255 Ala Lys Lys Asn 260 INFORMATION FOR SEQ ID NO:638: SEQUENCE CHARACTERISTICS: LENGTH: 191 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...191 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:638 Met Lys Asn Pro Gin Ala Asn Val Leu Lys Leu Phe Leu Asn Gin Val 1 5 10 Ala Asp Gin Lys Tyr Ile Asp Met Asn Asp Glu Lys Asn Tyr Asp Pro 25 Arg Glu Pro Glu Pro Pro Tyr Gly Thr Lys Gly Ala Leu Asp Glu Ile 40 Ile Arg Thr Asp Ala Arg Ser Trp Ala Asn Thr Pro Asp Asp Glu Phe 55 Gly Ser Ile Met Ser Ser Phe Lys Arg Phe Met Tyr Val Tyr Lys Asp 70 75 Pro Lys Val Arg Glu Ala Thr Ser Lys Met Ser Phe Asp Tyr Giu Glu 90 Leu Arg Thr Gly Asn Ile Ser Ile Tyr Ile Val Ile Ala Gin Ile Asp 100 105 110 Ile Gly Thr Leu Ser Ser Leu Val Arg Ala Phe Leu Glu Ser Ile Ala .115 120 125 Lys Asn Leu Met Val Lys Glu Ser Ser Lys Pro Glu Glu Arg Ile Phe 130 135 140 Ile Ile Ala Asp Glu Phe Val Arg Phe Gly Lys Leu Pro Phe Leu Leu 145 150 155 160 Glu Met Pro Ala Leu Cys Arg Ser Tyr Asn Val Val Pro Leu Phe Ile 165 170 175 Thr Gin Asp Tyr Ala Met Ile Arg Asn Thr Ile Ala Met Met Ile 180 185 190 INFORMATION FOR SEQ ID NO:639: SEQUENCE CHARACTERISTICS: LENGTH: 351 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES AMENDED HEE~ p CT/1' c, nli2 IpEA/S 18 D EC01996 (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .351 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:639 Met Ilie Se Giu Ile Ile Lys Phe Gin Leu Lys 1 Arg Leu Val Leu Asp Giu Thr Leu Sen Giy Ile Phe Ile Asn Lys Glu 130 Phe Giu 145 Gin Thr Asp Asp Lys Ala Phe Gly 210 Ser Thn 225 Gly Giu His Ser Asn Met Asn Met 290 Phe Phe 305 Giu Cys Ile Gly Lys Leu Asp Thr Trp Giu Lys 115 Ile Met Met Trp Leu 195 Glu Tyr Asn Ser Ilie 275 Giu Gly Ile Ile Giy Gly Leu Ser As n Cys 100 Giu Lys Lys Leu His 180 Gly Arg Asp Asp As n 260 Glu Ile Lys Lys Val1 340 5 Leu Ala Leu Cys Leu Val1 Asp Giu Giu Giu 165 Giu Ile Ser Thr Tyr 245 Asn Leu Asp Ala Asn 325 Trp As n Thr Lys As n 70 Ser Glu Thr Lys His 150 As n Arg Lys Tyr Arg 230 Lys Ile Thr G ly Lys 310 Lys Lys Lys Ala Arg 55 Ala Lys Giu Giu Ala 135 Ser Ala Phe Giu Ile 215 Gin Ile Lys Asn Se r 295 Val1 Val1 Lys Thr Pro 40 Val1 Lys Giu Giu Asp 120 Lys Lys Phe Gly Tyr 200 Arg Thr Thr Pro Ile 280 Lys Pro Lys Asn Leu 25 Leu Lys Val1 Phe Lys 105 Lys Val1 Giu Asp Gly Ser Gin Leu Trp Leu 265 Lys Tyr Giu Ser Thr 345 Lys Met Leu Asp Pro 90 His Giu Leu Phe Asn 170 Ile Asp Tyr Ser Leu 250 Met Lys Pro Thr Tyr 330 Tyr Thr Ala His G ly 75 Gin Lys G iu Arg Pro Gly Ser Glu Lys Ala 235 Lys Ser Giu Ile Trp 315 Asp Ser Gly Ser Lys Asn Sen Giu Gin Leu Gin 140 Asn Ala Arg Gly Lys 220 Met Pro As n Tyr His 300 Arg Asn Ile Ile ELeu Pro Ile G1n Tyr Ala Ala 125 Lys Lys Glu Glu Lys 205 Asp Ala Lys Thr Val1 285 Lys Asn Thr Ser Lys Leu Leu Lys Tyr Arg Leu 110 Lys Phe Lys Ser Asn 190 Ile Phe Asn Tyr Giu 270 Met Asp Lys Thr His 350 Met Ala Leu Giu Leu Giu Asn Lys Met Gin Phe 175 Thr Leu Glu Met Gin 255 Leu Gly Trp Ile Ala 335 His Ile Gly Sen Asp Asn Lys Leu Ile Ala Leu 160 Ile Tyr Ala Giu Ser 240 Leu Leu Cys G ly Trp 320 Glu INFORMATION FOR SEQ ID NO:640: SEQUENCE CHARACTERISTICS: LENGTH: 351 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein *~AT AMMFND SPHT PCT!US 9 09 1 a2 jPEA/US 18DEC1996.
(iii) HYI?OTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .351 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:640 1Met Ala Asp Ile Leu Ser Gin Giu Glu Ile Asp Ala Val1 Pro Ser Arg Ile Sen Gly Ile Giu 145 Val1 Pro Ala His Sen 225 Asn Val1 Lys Val1 Leu 305 Giu Leu Asp Gin Lys As n Gin Leu 0 ly Asp 130 Phe Met Thr Gin Ser 210 Ile Ser Ser 0 iu Aia 290 Ala Val1 Glu Giu Arg Giu Leu Leu Pro Thr 115 Arg Ser Gin Ile As n 195 Arg Leu Lys Val1 Met 275 Asn Ser Val1 Giu Asn Ser Gin Se r His Ser 100 Gly Leu Asp Ile Asp 180 Giu Gly Sen Lys Asp 260 Leu Asp Val1 Tyr Gin 340 Val1 Val1 Leu Sen Sen Pro Val1 Leu Ilie Leu 165 Ala Ile Met Lys Ser 245 Met Asp Giu Gly Sen 325 Arg Asp Thr Arg Gin 70 Val1 Thr Leu Gly Giu IS0 Lys Lys Ser Met Met 230 Ang Met Leu Val1 Phe 310 Giu Ang Ile Leu Ser 55 Val1 Asp Sen Giu G ly 135 Leu Giu Giu Ile As n 215 Giy As n Val1 Asp Sen 295 Gin Lys Arg Gin Tyr 40 Phe Ser Gin Phe Ile 120 Lys As n Val1 Ser Met 200 Ile Ser Lys Phe Val1 280 Val1 Giy Giu Gin Asn 25 Asp Arg Ser Met As n 105 As n Gly Leu Tnp Ser 185 Val1 Cys Arg Giu Leu 265 Gly Tyr Tyr Arg Sen 345 Val Phe Sen Ile Thr 90 Val1 Pro Sen Leu Ser 170 Ala Val1 Tyr Asp Leu 250 Giy Asp Vali Ang Thr 330 Gin Lys Ile Met 75 Tyr Phe Sen Ala Asp 155 Pro As n Leu Pro Phe 235 Gin Ala Thr His Lys 315 Lys Lys Ang His Ang Gly Sen Ile Tyr 140 Thn Val1 Val1 Giu Val1 220 Met Ala Val1 Ile Lys 300 Thr Glu Leu Lys Pro Asp Sen Glu Met Ala 125 Asp Ile Val1 Val1 Ile 205 Ile Leu Leu Giu Arg 285 Lys Ile Ile Leu Asp Asn Lys Ile Phe Lys 110 Phe Gin Leu Giu Gin 190 Ile Sen Ser Leu Leu 270 Leu Lys Gin Leu Giu Ile Arg Met Val1 Leu Pro Pro Asn Arg Met 175 Ile Ile Ile Giu Sen 255 Sen Asn Ang Ile Giu Val Ile Val Ala Giu Met Met Met Arg Gin 160 Tyr Vai Gly Giu Thn 240 Gly Leu Lys Tyr Lys 320 Met Trp Ala Met Leu Trp Ser 350 INFORMATION FOR SEQ ID NO:641: SEQUENCE CHARACTERISTICS: LENGTH: 145 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein AMENDED SH~EETJ PCT/US 96/09122 PT/US 9 6 0 9 122 IPE US 18 DEC 1996 534 (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...145 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:641 Met Arg Ile Val Phe Met Gly Thr Pro Ser Phe Ala Glu Val Ile Leu 1 5 10 Arg Ala Leu Val Glu Asn Glu Asp Lys Lys Ile Glu Val Val Gly Leu 25 Phe Thr Gln Arg Asp Lys Pro Phe Gly Arg Lys Lys Glu Leu Lys Ala 40 Pro Glu Thr Lys Thr Tyr Ile Leu Glu Asn His Leu Asn Ile Pro Ile 55 Phe Gln Pro Gln Ser Leu Lys Giu Pro Glu Val Gln Ile Leu Lys Gly 70 75 Leu Lys Pro Asp Phe Ile Val Val Val Ala Tyr Gly Lys Ile Leu Pro 90 Lys Glu Val Leu Thr Ile Ala Pro Cys Ile Asn Leu His Ala Ser Leu 100 105 110 Leu Pro Lys Tyr Arg Gly Ala Ser Pro Ile His Glu Met Ile Leu Asn 115 120 125 Asp Asp Arg Ile Tyr Gly Ile Ser Thr Met Leu Met Unk Phe Gly Ile 130 135 140 Gly 145 INFORMATION FOR SEQ ID NO:641: SEQUENCE CHARACTERISTICS: LENGTH: 145 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...145 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:641 Met Arg Ile Val Phe Met Gly Thr Pro Ser Phe Ala Glu Val Ile Leu 1 5 10 Arg Ala Leu Val Glu Asn Glu Asp Lys Lys Ile Glu Val Val Gly Leu 25 Phe Thr Gln Arg Asp Lys Pro Phe Gly Arg Lys Lys Glu Leu Lys Ala 40 Pro Glu Thr Lys Thr Tyr Ile Leu Glu Asn His Leu Asn Ile Pro Ile 55 Phe Gln Pro Gln Ser Leu Lys Glu Pro Glu Val Gln Ile Leu Lys Gly 70 75 Leu Lys Pro Asp Phe Ile Val Val Val Ala Tyr Gly Lys Ile Leu Pro PCT/US 9 q 12? IPENUS 18 DEC199 535 90 Lys Glu Val Leu Thr Ile Ala Pro Cys Ile Asn Leu His Ala Ser Leu 100 105 110 Leu Pro Lys Tyr Arg Gly Ala Ser Pro Ile His Glu Met Ile Leu Asn 115 120 125 Asp Asp Arg Ile Tyr Gly Ile Ser Thr Met Leu Met Unk Phe Gly Ile 130 135 140 Gly 145 INFORMATION FOR SEQ ID NO:642: SEQUENCE CHARACTERISTICS: LENGTH: 190 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...190 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:642 Met Pro Thr Met Leu Ala Val Gly Phe Trp Val Leu Val Phe Leu Ser 1 5 10 Thr Ser Asn Ala Val Asn Leu Thr Asp Gly Leu Asp Gly Leu Ala Ser 25 Val Pro Ser Ile Phe Thr Leu Leu Ser Leu Ser Ile Phe Val Tyr Val 40 Ala Gly Asn Ala Glu Phe Ser Lys Tyr Leu Leu Tyr Pro Lys Val Ile 55 Asp Val Gly Glu Leu Phe Val Ile Ser Leu Ala Leu Val Gly Ser Leu 70 75 Phe Gly Phe Leu Trp Tyr Asn Cys Asn Pro Ala Ser Val Phe Met Gly 90 Asp Ser Gly Ser Leu Ala Ile Gly Gly Phe Ile Ala Tyr Asn Ala Ile 100 105 110 Val Ser His Asn Glu Ile Leu Leu Val Leu Met Gly Ser Ile Phe Val 115 120 125 Ile Giu Thr Leu Ser Val Ile Leu Gin Val Gly Ser Tyr Lys Thr Arg 130 135 140 Lys Lys Arg Leu Phe Leu Met Ala Pro Ile His His His Phe Glu Gin 145 150 155 160 Lys Gly Trp Ala Glu Asn Lys Val Ile Val Arg Phe Trp Ile Ile Ser 165 170 175 Met Leu Ser Asn Leu Val Ala Leu Leu Ser Leu Lys Val Cys 180 185 190 INFORMATION FOR SEQ ID NO:643: SEQUENCE CHARACTERISTICS: LENGTH: 489 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein g'_AMENDED SHEET PCT/US 9 6 09 122 IPENUS 18 DEC1996 536 (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...489 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:643 Val Arg Phe Glu Asn Phe Ile Asn Arg Leu Ala Phe Tyr Met Ala Thr 1 5 10 Gly Ser Gly Lys Thr Ile Val Ile Ile Lys Leu Val Glu Leu Leu Ser 25 Val Ala Met Gly Met Gly Leu Ile Pro Lys Lys Asn Ile Met Phe Phe 40 Ser Ala Asn Glu His Leu Ile Lys Gln Phe Glu Lys Glu Ile Glu Lys 55 Tyr Asn Arg Asn Lys Asp Tyr Ser Lys Gin Ile Asp Phe Lys Asn Leu 70 75 Lys Ser Val Lys Asn Lys Asp Phe Tyr Arg Ala Pro Lys Asp Ser Leu 90 Met Lys Glu Ile Ala Leu Phe Tyr Tyr Arg Ala Asp Leu Met Ser Asp 100 105 110 Glu Giu Ser Lys Glu Asn Leu Leu Asn Tyr Lys Asp Cys Trp Asp Asn 115 120 125 Gly GIu Asn Tyr Val Ile Leu Asp Glu Ala His Lys Gly Asn Lys Thr 130 135 140 Glu Ser Lys Arg Gln Ala Ile Phe Ser Leu Leu Ser Leu Lys Gly Phe 145 150 155 160 Leu Phe Asn Phe Ser Ala Thr Phe Thr Glu Glu Ser Asp Leu Ile Thr 165 170 175 Ala Val Tyr Asn Leu Ser Val Gly Glu Trp Val Lys Leu Gly Tyr Gly 180 185 190 Lys Glu-Ser Val Leu Leu Lys Lys Asn Asn Leu Asn Ala Phe Lys Glu 195 200 205 Leu Lys Asp Leu Asn Asp Arg Glu Lys Glu Ile Ala Leu Leu Lys Ala 210 215 220 Leu Leu Leu Leu Gly Met Gin Lys Arg Tyr Lys Val Glu Gly Tyr Phe 225 230 235 240 His Asp Pro Leu Met Leu Val Phe Thr His Ser Val Asn Met Glu Asn 245 250 255 Ser Asp Ala Unk Ile Phe Phe Lys Thr Leu Ala Arg Val Ile Glu Asn 260 265 270 Asp Asp Glu Ser Asp Phe Ser Lys Ala Lys Asp Asp Leu Leu Glu Glu 275 280 285 Leu Lys Asn Pro Glu Phe Leu Phe Ser Asp Gly Lys Asp Lys Glu Lys 290 295 300 Asp Tyr Lys Ile Glu Val Phe Lys Glu Ser Leu Lys Gly Met Asp Phe 305 310 315 320 Lys Gly Leu Lys Glu Ala Val Phe Tyr Ala Ser Asn Gly His Ile Glu 325 330 335 Val Ile Ile Asn Pro Lys Asn Asn Gin Glu Ile Ala Phe Lys Leu Asn 340 345 350 Thr Ser Asp Lys Val Phe Cys Leu Ile Arg Ile Gly Asp Ile Thr Glu 355 360 365 Trp Ile Arg Glu Lys Leu Lys Ser Val Lys Val Val Ser Lys Asn Leu 370 375 380 Ser Phe Lys Glu Glu Ser Tyr Phe Ser Gin Ile Asp Lys Ser Ser Ile 385 390 395 400 Asn Ile Leu Val Gly Ser Arg Ala Phe Asp Thr Gly Trp Asp Ser Thr 405 410 415 g Pro Ser Val Ile Leu Phe Leu Asn Ile Gly Leu Asp Asp Asp Ala JsVTQy> I *rMNr% eueT POUs 96/09 122 IPENUJS 18 :;,1996 Lys Val1 Ile 465 Cys '420 425 430 Leu Val Lys Gin Ser Phe Gly Arg Giy Val Arg Ile Giu Ser 435 440 445 Asn Gin Arg Gin Arg Leu Ala Tyr Leu Giu Ile Asp Giu Ala 455 460 Glu Gin Ala Giu Thr Lys Arg Cys Asn Ala Gly Asn Ala Phe 470 475 480 Thr Tyr Gin Pro Cys Lys Pro 485 INFORMATION FOR SEQ ID NO:644: SEQUENCE CHARACTERISTICS: LENGTH: 248 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .248 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:644 Met Arg Phe Tyr Phe Lys Phe Leu Trp Leu Leu 1 Phe Val1 Gin Ang Arg Pro Sen Val Leu 145 Ile Giu Asp Phe Ala 225 Tyr Lys Ala Leu Leu Thn Leu Ser 130 Asn Giy Leu Gin Val1 210 Val1 Phe Ser Tyr Ile As n Phe Asn 115 His Gly Gin Val1 Val1 195 Giy Leu Leu Ala Phe Leu Ser Met 100 Pro Asn Phe Asn Val1 180 Leu Glu Lys 5 Asp Leu Phe Glu Ile Thr Ile Gin Leu Gin 165 Asp Thn Val1 Asn Gly 245 Ile Met Gin Ala 70 Tyr Ser Val1 Ala Asn
ISO
Val1 Phe Sen Ser Ala 230 Lys Ser Ala 55 Leu Pro Phe Asn Ile 135 Ala Leu Ile Gly Sen 215 Phe Gly Ala 40 Gin Lys Leu Ile Leu 120 Gly His Gly Val1 Leu 200 Val1 Leu Ser Lys Asn Leu Giu As n 105 Giu Ile Lys Phe Pro 185 Asp Giu Ser Sen Ser Lys As n 75 Pro Giu Asn Val Cys 155 Giy Ala Ile His Ala 235 Gly Tyr Leu Giu Ala Lys Asp Lys Leu 140 Ala Thr Giu Phe Tyr 220 Lys Ile Ile Leu Phe Asp Met Thr Ile 125 Glu Tyr As n Ile Gly 205 Thr Leu Ile Ang Val1 Giu G iu Thr Val1 Leu Ang Met 160 Gin Gly Val Ser His 240 Val Phe Leu Sen Vai Lys Asn /AMENDED SHET POT!US 96/09122 IPEA/US 18 DEC1996 538 INFORMATION FOR SEQ ID NO:644: SEQUENCE CHARACTERISTICS: LENGTH: 248 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...248 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:644 Met Arg Phe Tyr Phe Lys Phe Leu Trp Leu Leu Gly Ile Phe Leu Ile 1 5 10 Phe Tyr Phe Leu Asp Ile Lys Gly Ser Ser Ser Tyr Ile Ser Asp Arg 25 Val Lys Ser Ala Leu Met Ser Ala Lys Asn Ser Leu Leu Asp Asn Val 40 Gin Ala Tyr Phe Phe Gln Ala Gln Asn Ile Lys Glu Phe Gln Lys Glu 55 Arg Leu Ile Leu Glu Ala Leu Lys Leu Glu Asn Ala Asp Leu Lys Glu 70 75 Arg Leu Asn Ser Ile Tyr Pro Leu Glu Asn Pro Lys Met Thr Tyr Thr 90 Pro Thr Phe Met Thr Ser Phe Ile Asn Leu Glu Asp Thr His Ser Val 100 105 110 Ser Leu Asn Pro Ile Val Asn Leu Glu Glu Asn Lys Ile Tyr Gly Leu 115 120 125 Val Ser His Asn Gln Ala Ile Gly Ile Ala Val Leu Glu Lys Gly Arg 130 135 140 Leu Asn Gly Phe Leu Asn Ala His Lys Arg Cys Ala Tyr Ser Val Met 145 150 155 160 Ile Gly Gln Asn Gln Val Leu Gly Phe Ile Gly Thr Asn Phe Lys Gin 165 170 175 Glu Leu Val Val Asp Phe Ile Val Pro Ser Ala Glu Ile Asn Ile Gly 180 185 190 Asp Gln Val Leu Thr Ser Gly Leu Asp Gly Ile Phe Gly Ala Gly Val 195 200 205 Phe Val Gly Glu Val Ser Ser Val Glu Asp His Tyr Thr Tyr Lys Ser 210 215 220 Ala Val Leu Lys Asn Ala Phe Leu Ser Glu Ala Lys Leu Leu Arg His 225 230 235 240 Val Phe Leu Ser Gly Val Lys Asn 245 INFORMATION FOR SEQ ID NO:645: SEQUENCE CHARACTERISTICS: LENGTH: 119 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein k (iii) HYPOTHETICAL: YES Ag~orn 1 c o-c PCT/US 96/0 122 IPEA/US 18 DEC 1996 539 (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION 1...119 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:645 Leu Ala Leu Arg Leu Pro Phe Leu "Ile Ala His Val Ile Asn Met Phe 1 5 10 Leu Phe Tyr Leu Ile Gly Arg Lys Ile Leu Lys Lys Pro Lys Asp Ala 25 Leu Tyr Val Val Leu Thr Tyr Ala Leu Leu Pro Gly Val Asn Leu Phe 40 Ala Ile Leu Leu Ala Lys Ser Val Leu Val Leu Ser Leu Gly Leu Leu 55 Ile Ser Tyr Leu Tyr Ile Lys Thr Gin Lys Ile Pro Tyr Leu Thr Leu 70 75 Ser Ala Cys Ala Phe Leu Asp Gly Ala Phe Ile Pro Leu Leu Leu Gly 90 Val Phe Ala Tyr Ala Leu Arg Lys Thr Ala Ile Leu Arg Ala Arg Ser 100 105 110 Leu Leu Trp Trp Phe Unk Leu 115 INFORMATION FOR SEQ ID NO:645: SEQUENCE CHARACTERISTICS: LENGTH: 119 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...119 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:645 Leu Ala Leu Arg Leu Pro Phe Leu Ile Ala His Val Ile Asn Met Phe 1 5 10 Leu Phe Tyr Leu Ile Gly Arg Lys Ile Leu Lys Lys Pro Lys Asp Ala 25 Leu Tyr Val Val Leu Thr Tyr Ala Leu Leu Pro Gly Val Asn Leu Phe 40 Ala Ile Leu Leu Ala Lys Ser Val Leu Val Leu Ser Leu Gly Leu Leu 55 Ile Ser Tyr Leu Tyr Ile Lys Thr Gin Lys Ile Pro Tyr Leu Thr Leu 70 75 Ser Ala Cys Ala Phe Leu Asp Gly Ala Phe Ile Pro Leu Leu Leu Gly 90 Val Phe Ala Tyr Ala Leu Arg Lys Thr Ala Ile Leu Arg Ala Arg Ser 100 105 110 Leu Leu Trp Trp Phe Unk Leu 115 IV A I fielkinrft Currw: PCT/US 9 6 Oq 122 IPENUS 18 DEC1996 540 INFORMATION FOR SEQ ID NO:646: SEQUENCE CHARACTERISTICS: LENGTH: 108 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...108 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:646 Val Asn Leu Met Asp Tyr Phe Ser Lys Ser Leu Phe Leu Asn Ser Leu 1 5 10 Asn Thr Gin Arg Leu Ile Val Ser Asn Lys Leu Ala Ile Asp Val Gin 25 Tyr Gly Met Leu Gin Ser Val Arg Lys Asn Tyr Pro Asp Val Val Asp 40 Gly Gly Val Arg Glu Gly Pro Phe Trp Val Leu Ala Gly Ala Leu Met 55 Pro Ser Ile Leu Ile Glu Ile Gly Tyr Asn Ser His Ala Ile Glu Ser 70 75 Lys Arg Ile Gin Ser Lys Pro Tyr Gin Lys Ile Leu Ala Lys Gly Ile 90 Ala Asp Gly Ile Asp Ser Phe Phe Ser Lys Asn Asp 100 105 INFORMATION FOR SEQ ID NO:646: SEQUENCE CHARACTERISTICS: LENGTH: 108 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...108 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:646 Val Asn Leu Met Asp Tyr Phe Ser Lys Ser Leu Phe Leu Asn Ser Leu 1 5 10 Asn Thr Gin Arg Leu Ile Val Ser Asn Lys Leu Ala Ile Asp Val Gin 25 Tyr Gly Met Leu Gin Ser Val Arg Lys Asn Tyr Pro Asp Val Val Asp 40 Gly Gly Val Arg Glu Gly Pro Phe Trp Val Leu Ala Gly Ala Leu Met 55 Pro Ser Ile Leu Ile Glu Ile Gly Tyr Asn Ser His Ala Ile GIu Ser v AURNDD SHEET PCT/US 9 6 0 9 12 IPENUS 18 DEC 1996 541 70 75 Lys Arg Ile Gln Ser Lys Pro Tyr Gln Lys Ile Leu Ala Lys Gly Ile 90 Ala Asp Gly Ile Asp Ser Phe Phe Ser Lys Asn Asp 100 105 INFORMATION FOR SEQ ID NO:647: SEQUENCE CHARACTERISTICS: LENGTH: 213 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...213 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:647 Val Phe Lys Asn Ser Leu Phe Gly Ile Ser Ile Ser Met Leu Ile Thr 1 5 10 Trp Val Leu Thr Ala Cys Ile Leu Ile Phe Ile Leu Phe Val Pro Asn 25 Phe Thr Leu Thr His Pro Asn Phe His Phe Thr Pro Phe Glu Lys Thr 40 Tyr Phe Gln Ile Leu Gly Leu Val Gly Ile Val Ser Ser Ile Ile Phe 55 Thr Gly Phe Leu Ala Asp Lys Ile Lys Pro His Lys Val Cys Met Ala 70 75 Phe Ser Thr Thr Phe Gly Phe Phe Gly Phe Leu Phe Phe Lys Glu Phe 90 Tyr Ser Asn Ala Pro Ser Leu Val Asn Thr Ile Ile Leu Tyr Phe Leu 100 105 110 Ala Cys Phe Cys Ala Gly Ile Met Asn Phe Cys Pro Ile Phe Met Ser 115 120 125 Asp Val Phe Ser Ala Lys Ile Arg Phe Ser Gly Ile Ser Phe Ala Tyr 130 135 140 Asn Ile Ala Tyr Ala Ile Thr Ala Gly Phe Thr Pro Gln Leu Ser Ser 145 150 155 160 Trp Leu Asn Ala Lys Ala Ile Ala Val Pro Glu Ser Leu Gln Ser Tyr 165 170 175 Gly Leu Ser Phe Tyr Ile Leu Ile Val Ser Leu Ile Ala Phe Ile Thr 180 185 190 Ser Leu Leu Met Ala Pro Ile Tyr His Lys Ser Asn Thr Gln His Glu 195 200 205 Val Ser Pro Thr Ala 210 INFORMATION FOR SEQ ID NO:648: SEQUENCE CHARACTERISTICS: LENGTH: 157 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein AMF~~fl 542 (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...157 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:648 Leu Ala Ser Arg Tyr Ser Val Ala Val Gly Asn Leu Phe Ser Glu His 1 5 10 Leu Tyr Asp Leu Arg Asn Glu Thr Met Thr Asn Leu Ile Gly Phe Leu 25 Leu Val Leu Ala Ser Ile Trp Val Phe Phe Leu Ala Leu Gly Val Leu 40 Leu Gly Lys Met Leu Val Phe Ser Gly Leu Gly Ile Ile Asp Lys Ala 55 Leu Gly Phe Ile Phe Ser Cys Leu Lys Thr Phe Leu Val Leu Ser Phe 70 75 Ile Leu Tyr Ala Leu Ser Lys Met Asp Leu Met Lys Asp Ala Asn Ala 90 Tyr Leu Gln Glu Lys Unk Unk Ile Phe Pro Thr Unk Lys Unk Unk Unk 100 105 110 Ser Lys Ile Met Arg Leu Asp Gly Val Lys His Val Glu Lys Asn Leu 115 120 125 Lys Asp Asn Leu Glu Glu Met Ser Asp Glu Val Lys Asn Lys Gly Ser 130 135 140 Ile Asp Asn Ala Lys Glu Ser Phe Asn Lys Gly Tyr Gly 145 150 155 INFORMATION FOR SEQ ID NO:648: SEQUENCE CHARACTERISTICS: LENGTH: 157 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...157 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:648 Leu Ala Ser Arg Tyr Ser Val Ala Val Gly Asn Leu Phe Ser Glu His 1 5 10 Leu Tyr Asp Leu Arg Asn Glu Thr Met Thr Asn Leu Ile Gly Phe Leu 25 Leu Val Leu Ala Ser Ile Trp Val Phe Phe Leu Ala Leu Gly Val Leu 40 Leu Gly Lys Met Leu Val Phe Ser Gly Leu Gly Ile Ile Asp Lys Ala 55 Leu Gly Phe Ile Phe Ser Cys Leu Lys Thr Phe Leu Val Leu Ser Phe 70 75 Ile Leu Tyr Ala Leu Ser Lys Met Asp Leu Met Lys Asp Ala Asn Ala AMENDED S T, PCTUS 96/09122 IPENUS 18 DEC 199s Tyr Ser Lys Ile 145 90 Gin Giu Lys Unk Unk Ile Phe Pro Thr Unk Lys Unk Unk Unk 100 105 110 Ile Met Arg Leu Asp Gly Val Lys His Val Giu Lys Asn Leu 115 120 125 Asn Leu Glu Glu Met Ser Asp Giu Val Lys Asn Lys Gly Ser 135 140 Asn Ala Lys Glu Ser Phe Asn Lys Gly Tyr Gly 150 155 INFORMATION FOR SEQ ID NO:649: Wi SEQUENCE CHARACTERISTICS: LENGTH: 312 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .312 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:649 Met Lys Ser Asp Lys Pro Phe Leu Glu Arg Tyr Phe 1 Leu Tyr Phe Gly Ala Val1 Giu Ser Lys 145 Asn Pro Leu Asn Arg 225 Arg Leu Gin Lys Lys Val1 Ser Ala Glu 130 Ile Ala Ser Val Pro 210 Leu Asp Gin Cys Ilie Thr Val1 Val1 Tyr 115 Lys Val Leu Gly Ile 195 Thr Asp His 5 Lys Gly Ile Ala Pro Ile Pro Phe Sen Arg Lys Gly 100 Leu Leu Arg Giu Phe Leu Leu Lys 165 Leu Tyr 180 Thr Giu Lys Arg Ala Phe Ala Pro 245 Leu Thr Ile Ilie 70 Gly Asn Ala Leu Asp 150 Pro Arg Asp Met Leu 230 Phe Ile Ile Ser 55 Leu Tyr Ile Leu Gly 135 Asp Lys Giu Lys Leu 215 Pro Asp Phe Lys 40 Ile Glu Gin Leu As n 120 Val1 Gly Val1 Asn Asp 200 Leu Lys Leu Ala 25 Arg Gly Ile Arg Val1 105 Leu Leu Phe Pro Ile 185 Tyr Val1 Giu Lys Val1 265 10 Leu Lys Asn Ala Asp 90 Pro Lys Lys Arg Pro 170 Lys Gin Thn Val1 Leu 250 Thr Tyr Thr Leu Pro 75 Sen Gin Gin Aia Phe 155 Tyr Ser Arg Ala Val1 235 Leu Ser Pro Ala Ile Ang Lys Lys Ala Leu 140 As n Tyr Tyr Ile Ile 220 Lys G iu Lys Tyr Phe Lys Ala Tyr Gly Thr Ser 125 Giu Phe Pro Lys Thr 205 Ala Lys Lys Asp Asp Ser Lys Giy Gin Leu Aia 110 Val Leu Asn Phe Glu 190 Ser As n Leu Giu Leu 270 Pro Leu His Gly Giu Val1 Gly Ile G ly Gin Cys 175 Ala Ile Pro Tyr Phe 255 Val1 Thn Ile Asp Sen Val1 Val Asp Val Ser Phe 160 Leu His Thr Sen Phe 240 Tyr Lys Gin Asn Asn Ala Thr Ser Leu Leu AMENDED PCT/US 96/09122 IPENUS 18DEC199Z 544 Leu Gin Asp Cys Lys Leu Pro Leu Ser Val Leu Asp Leu Lys Leu Glu 275 280 285 Ile Cys Pro Lys Val Leu Glu Glu Ile Asp Arg Tyr Ile Leu Ser Tyr 290 295 300 Pro Cys Asn Ile Lys Glu His Leu 305 310 INFORMATION FOR SEQ ID NO:650: SEQUENCE CHARACTERISTICS: LENGTH: 56 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...56 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:650 Met Ser Leu Gly Ala Val Ile Arg Leu Ile Phe Cys Tyr Lys Leu Glu 1 5 10 Gly Val Ile Leu Asp Leu Lys Arg Ile Asn Phe Lys Ser Tyr Tyr Pro 25 Asn Asn Lys Asn Ala Leu Phe Ile Asn Asn Lys Lys Asn Pro Leu Ser 40 Ser Thr Ser Lys Phe Ile Leu Leu INFORMATION FOR SEQ ID NO:651: SEQUENCE CHARACTERISTICS: LENGTH: 199 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...199 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:651 Met Leu Glu Thr Thr Ile Asp Phe Ser Arg Tyr Ser Ser Val Lys Ile 1 5 10 Gly Ala Pro Leu Lys Val Ser Val Leu Glu Asn Asp Asn Glu Ile Ser 25 Gin Glu His Gin Ile Ile Gly Leu Ala Asn Asn Leu Leu Ile Ala Pro 40 Asp Val Lys Asn Leu Ala Leu Leu Gly Lys Asn Tyr Asp Tyr Ile Cys.
AMENDED SHEET, PCT/US 96/ 0 9 122 IPEAUS 18 DEC199o 545 55 Asp Lys Gly Glu Trp Val Glu Val Gly Gly Ala Ala Asn Ala Ser Lys 70 75 Ile Phe Asn Tyr Phe Arg Ala Asn Asp Leu Glu Gly Leu Glu Phe Leu 90 Gly Gln Leu Pro Gly Thr Leu Gly Ala Leu Val Lys Met Asn Ala Gly 100 105 110 Met Lys Glu Phe Glu Ile Lys Asn Val Leu Glu Ser Ala Cys Val Asn 115 120 125 Gly Glu Trp Leu Glu Lys Glu Ala Leu Gly Leu Asp Tyr Arg Ser Ser 130 135 140 Gly Phe Asn Gly Val Val Leu Arg Ala Arg Phe Lys Lys Thr His Gly 145 150 155 160 Phe Arg Glu Gly Val Leu Lys Ala Cys Lys Ser Met Arg Lys Ser His 165 170 175 Pro Lys Leu Pro Asn Phe Gly Ser Cys Phe Lys Asn Pro Pro Asn Asp 180 185 190 Tyr Ala Gly Arg Leu Leu Glu 195 INFORMATION FOR SEQ ID NO:652: SEQUENCE CHARACTERISTICS: LENGTH: 81 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...81 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:652 Leu Ser Lys Gin Ser Ala Asp Ile Val Ile Thr Asn Asp Ser Leu Ser 1 5 10 Ser Leu Val Lys Val Leu Ala Ile Ala Lys Lys Thr Lys Ser Ile Thr 25 Trp Gin Asn Ile Leu Phe Ala Leu Gly Ile Lys Ala Val Phe Ile Val 40 Leu Gly Leu Met Gly Val Ala Ser Leu Trp Glu Ala Val Phe Gly Asp 55 Val Gly Val Thr Leu Leu Ala Leu Ala Asn Ser Unk Arg Thr Met Arg 70 75 Ala INFORMATION FOR SEQ ID NO:652: SEQUENCE CHARACTERISTICS: LENGTH: 81 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES O^ AuTsFO SHEET POT/US 9 6 09 12 IPENUS 18 DEC 1996 546 (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...81 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:652 Leu Ser Lys Gln Ser Ala Asp Ile Val Ile Thr Asn Asp Ser Leu Ser 1 5 10 Ser Leu Val Lys Val Leu Ala Ile Ala Lys Lys Thr Lys Ser Ile Thr 25 Trp Gin Asn Ile Leu Phe Ala Leu Gly Ile Lys Ala Val Phe Ile Val 40 Leu Gly Leu Met Gly Val Ala Ser Leu Trp Glu Ala Val Phe Gly Asp 55 Val Gly Val Thr Leu Leu Ala Leu Ala Asn Ser Unk Arg Thr Met Arg 70 75 Ala INFORMATION FOR SEQ ID NO:653: SEQUENCE CHARACTERISTICS: LENGTH: 89 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...89 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:653 Met Leu Lys Asn Gly Asp Lys Ile Pro Asp Ala Ile Leu Val Asp Ile 1 5 10 Glu Met Pro Lys Met Asp Gly Tyr Thr Phe Ala Ser Glu Val Arg Lys 25 Tyr Asn Lys Phe Lys Asn Leu Pro Leu Ile Ala Val Thr Ser Arg Val 40 Thr Lys Thr Asp Arg Met Arg Gly Val Glu Ser Gly Met Thr Glu Tyr 55 Ile Thr Lys Pro Tyr Ser Gly Glu Tyr Leu Thr Thr Val Val Lys Arg 70 75 Ser Ile Lys Leu Glu Gly Asp Gln Ser INFORMATION FOR SEQ ID NO:654: SEQUENCE CHARACTERISTICS: LENGTH: 111 amino acids TYPE: amino acid TOPOLOGY: linear 7 ~AmPmflf qHFFT, PCT/US 96/09 122 IPEA/US 18 DEC 1996 (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...111 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:654 Val Phe Glu Pro Val Ile Ala Tyr Lys Leu Phe His Ser Phe Val Ile 1 5 10 Leu Gly Cys Ala Ile Glu Thr Leu Thr Thr Lys Cys Val Glu Gly Ile 25 Thr Ala Asn Glu Lys Ile Cys His Asp Tyr Val Phe Asn Ser Ile Gly 40 Ile Val Thr Ala Leu Asn Pro His Ile Gly Tyr Glu Lys Ser Ala Met 55 Ile Ala Lys Glu Ala Leu Lys Ser Asp Arg Ser Ile Tyr Asp Ile Ala 70 75 Leu Glu Lys Lys Ile Leu Thr Lys Glu Gin Leu Asp Asp Ile Phe Lys 90 Pro Glu Asn Met Leu Arg Thr His Ala Phe Lys Lys His Lys Asp 100 105 110 INFORMATION FOR SEQ ID NO:655: SEQUENCE CHARACTERISTICS: LENGTH: 65 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...65 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:655 Met Leu Arg Leu Leu Ala Gln Lys Ser Ala Ile Lys Leu Ile Leu Ile 1 5 10 Pro Pro Ser Ala Asn Ala Leu Gly Ile Ala Ser Ile Cys Glu Leu Ser 25 Glu Glu Val Phe Glu His Glu Lys Ile Val Gly Ile Arg Ala Gln Gly 40 Asp Phe Thr Ile Asn Ser Asp Asp Arg Gly Phe Trp Glu Arg Arg Cys 55 Gin INFORMATION FOR SEQ ID NO:656: SEQUENCE CHARACTERISTICS: LENGTH: 268 amino acids AMENDD Sh~f raRV 9 bi 548 TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc~feature LOCATION .268 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:656 Met Lys Lys Leu Leu Leu Leu Leu Giu His Lys Ile 1 Leu Giu Ser Thr As n Gin Pro Asn Gin 145 Glu Gly Val1 Ser Leu 225 Phe Ser Ile Ile Sen Ile Ile Lys Gin Arg 130 Pro Lys Ser Ser Phe 210 Phe Cys Leu Ile Lys Tyr Asn Giu Leu Ser 115 Leu Pro Arg Ph.
Phe 195 Leu Cys Ph.
Glu 5 Ile Lys Phe Val1 Thr As n Phe Ile Ser Leu 165 Leu Ser Ala Pro Lys 245 Sen Val1 Ala Gin Lys 70 Gin Leu Ph.
Leu Ile iso Giu Leu Arg Ph.
Leu 230 Ph.
Ser Leu Val1 Ala 55 Pro Lys Pro As n Ala 135 Lys Lys Ser Giy Ser 215 Se r Ser Leu Val1 Asn 40 Tyr As n Asp Lys Tyr 120 Ser Asn G iu Ser Ile 200 Ser Leu Arg Ser Giy Val1 Giu Asp Leu Asp 105 As n Arg Ser Trp Ser 185 dly Ser Ph.
Glu Arg 265 10 Phe Ser Gly Giu Asp 90 Phe Thr Ile Val1 Ala 170 Ser Leu Leu Cys Leu 250 Leu Phe Leu Gin Gly Ile Lys Thr Lys 75 Asp Phe Asn Lys Ala Asn Sen Ser 140 Ser His 155 Lys Pro Ser Phe Asp Cys Ph. Ser 220 Ser Leu 235 Val Asn Giy Ser Val1 Ph.
Lys Asn Ser As n Thr Giu 125 Gin Ile Ser Ser Giu 205 Leu Ile Ala Lys Tyr Phe Lys Val1 Ala Leu 110 Asp Lys Lys Val1 Sen 190 Lys Leu Gly Sen Ile Glu Pro Ile As n Leu Ile Giu Glu Ser Ser 175 Ph.
Leu Ser Leu Asn 255 Gly Gin Thr Asp Glu Val1 Lys Lys Thr Lys 160 Ph.
Giu Lys Ser Ile 240 Asn INFORMATION FOR SEQ ID NO:657: i)SEQUENCE CHARACTERISTICS: LENGTH: 100 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori AlActinm Qw= PCT/US 96/09122Z IPEUS 18 DEC1996 549 (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...100 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:657 Met Gly Ala Ile Ala Ser Cys Tyr Ala His Gln Ile Ile Leu Thr Ser 1 5 10 Asp Asn Pro Arg Ser Glu Asn Glu Glu Asp Ile Ile Lys Asp Ile Leu 25 Lys Gly Ile Asn Asn Ser Ser Lys Val Ile Val Glu Lys Asp Arg Lys 40 Lys Ala Ile Leu Asn Ala Leu Glu Asn Leu Lys Asp Asp Glu Val Leu 55 Leu Ile Leu Gly Lys Gly Asp Glu Asn Ile Gln Ile Phe Lys Asp Lys 70 75 Thr Ile Phe Phe Ser Asp Gln Glu Val Val Lys Asp Tyr Tyr Leu Asn 90 Leu Lys Gln Gly 100 INFORMATION FOR SEQ ID NO:658: SEQUENCE CHARACTERISTICS: LENGTH: 80 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...80 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:658 Val Met Asp Lys Leu Thr Lys Ser Leu Gln Thr Gln Lys Asn Phe Ala 1 5 10 Tyr Leu Gly Lys Ile Lys Pro Gln Gln Leu Ala Asp Phe Ile Ile Asn 25 Glu His Pro Gln Thr Ile Ala Leu Ile Leu Ala His Met Glu Unk Pro 40 Asn Ala Ala Glu Thr Leu Ser Tyr Phe Pro Asp Glu Met Lys Ala Glu 55 Ile Ser Ile Arg Met Ala Asn Phe Arg Arg Asn Ile Ala Pro Ser Gly 70 75 INFORMATION FOR SEQ ID NO:659: SEQUENCE CHARACTERISTICS: LENGTH: 205 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES -o R L/j PCT/US 9 6 09 1 IPENUS 1S DEC1996 550 (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...205 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:659 Met Arg Tyr Phe Arg Ser Ala Phe Leu Leu Phe Phe Met Thr Leu Phe 1 5 10 Phe Val Ser Cys Ser Lys His Pro Phe Ser Lys Gin Thr Pro Lys Thr 25 Lys Glu Arg Ile Arg Gin Glu Glu Ala Asn Lys Lys Arg Glu Glu Thr 40 Leu Asn Ala Leu Arg Gin Phe Arg Leu Ile Tyr Ile Asn Thr Pro Val 55 Phe Arg Phe Tyr Asp Tyr Gly Thr Ile Lys Thr Asp Lys Asp His Asn 70 75 Thr Glu Val Thr Leu Tyr Lys Leu Ser Gln Lys Val Gly Asp Ile Tyr 90 Met Thr Lys Arg Ser Ile Cys Phe Ser Gln Lys Cys Ser Ala Lys Trp 100 105 110 Ile Ala Ala Arg Asp Leu Phe Gly Lys Val Ser Tyr Gly Asp Leu Phe 115 120 125 Asp Asp Ile Val Leu Gly Arg Asp Ile Phe Lys Gly Leu Gly Lys Arg 130 135 140 His Leu Thr Pro Glu Tyr Val Ile Gln Arg Phe Gin Lys Ser Gly Glu 145 150 155 160 Ile Ile Leu Tyr Glu Arg Lys Asn Gly Leu Ile Ser Phe Gln Asn Leu 165 170 175 Thr Gln Lys Ile Ala Ile Arg Ile Glu Pro Tyr Glu Pro Ser Leu Gin 180 185 190 Asp Leu Glu Asp Asn Glu Asn Ala Asp Ser Glu Leu Gin 195 200 205 INFORMATION FOR SEQ ID NO:660: SEQUENCE CHARACTERISTICS: LENGTH: 124 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...124 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:660 Met Arg Ile Glu Glu Asn Gly Val Ile Ser Leu Ala Phe Ser Asn Gly 1 5 10 Val Val Glu Pro Val Ala Arg Ile Gly Ile Unk Ala Phe Thr Asn Asp 25 Gin Gly Leu Arg Lys Ile Gly Gly Asn Leu Tyr Glu Met Gin Glu Gly y RA 35 40 hr Ile Asn Gly Glu Asn Arg Pro Leu Unk Gly Asn Pro Ile Leu Gly -41 (<PVT O__AMFfFrD
SHEETI
PCT/US 9 6 0912.
SDE 1996 551 55 Trp Asp Glu Glu Gly Lys Leu Lys Phe Gly Lys Ile Arg His Lys Tyr 70 75 Leu Glu Thr Ser Asn Val Asn Ala Gly Asn Ala Leu Thr Asn Leu Ile 90 Leu Met Gln Arg Gly Tyr Ser Met Asn Ala Arg Ala Phe Gly Ala Gly 100 105 110 Asp Asp Met Ile Lys Glu Ala Ile Ser Leu Lys Lys 115 120 INFORMATION FOR SEQ ID NO:661: SEQUENCE CHARACTERISTICS: LENGTH: 93 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...93 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:661 Val Glu Ala Arg Tyr Tyr Tyr Gly Asp Thr Ser 1 5 10 Val Gly Val Leu Gln Glu Phe Ala His Phe Gly 25 Ser Leu Asn Thr Phe Lys Ile Asn Ala Ala Arg 40 Tyr Ala Arg Ala Met Met Gly Gly Glu Leu Gln 1 55 Phe Leu Asn Leu Gly Val Val Tyr Leu His Asn 1 70 75 Ser His Phe Ala Ser Asn Leu Gly Met Arg Tyr INFORMATION FOR SEQ ID NO:662: SEQUENCE CHARACTERISTICS: LENGTH: 80 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...80 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:662 Phe Tyr Leu His Asn Asp Val Ala Pro Leu Ser Thr Ala Lys Glu Val Ile Ser Asn Ala Phe o 2_ AMENDED SHEET; PCT/US 96/09122 Met 1 Ser Glu Phe Glu Asn Leu Arg His Phe Arg Lys Leu 5 10 Leu Leu Leu Gln Ala Asp Met Thr Gin Leu Thr Ser Pro Thr Ala Lys Gly Leu Ala Ile Phe Ile Trp Lys Leu Met Thr Val Leu Ala Leu Lys 70 552 Ile Ala Thr Phe Gly Ile Asn Leu Unk Val Gly Ser Val Trp Gin INFORMATION FOR SEQ ID NO:662: SEQUENCE CHARACTERISTICS: LENGTH: 80 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...80 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:662 Met Lys Asn Leu Arg His Phe Arg Lys Leu Ile Ala Phe Leu Gly Phe 1 5 10 Ser Pro Leu Leu Leu Gln Ala Asp Met Thr Thr Phe Phe Asn Ser Ile 25 Glu Gln Gln Leu Thr Ser Pro Thr Ala Lys Gly Ile Leu Met Val Ile 40 Phe Leu Gly Leu Ala Ile Phe Ile Trp Lys Asn Leu Asp Arg Trp Lys 55 Glu Ile Leu Met Thr Val Leu Ala Leu Lys Unk Val Pro Met Gln Unk 70 75 (2) Val o 4 0LO 751, INFORMATION FOR SEQ ID NO:663: SEQUENCE CHARACTERISTICS: LENGTH: 214 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...214 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:663 Glu Glu Leu Ala Lys Leu Ile Asn Asn Asn Asn Asn Asn Lys Lys A%1C1k1MCn CUCCT PCT/US 96 912 IftAUS 18 DEC1 553 1 5 10 Leu Arg Gly Phe Phe Leu Lys Val Leu Leu Ser Leu Val Val Phe Ser 25 Ser Tyr Gly Ser Ala Asn Asp Asp Lys Glu Ala Lys Lys Glu Ala Leu 40 Glu Lys Glu Lys Asn Thr Pro Asn Gly Leu Val Tyr Thr Asn Leu Asp 55 Phe Asp Ser Phe Lys Ala Thr Ile Lys Asn Leu Lys Asp Lys Lys Val 70 75 Thr Phe Lys Glu Val Asn Pro Asp Ile Ile Lys Asp Glu Val Phe Asp 90 Phe Val Ile Val Asn Arg Val Leu Lys Lys Ile Lys Asp Leu Lys His 100 105 110 Tyr Asp Pro Val Ile Glu Lys Ile Phe Asp Glu Lys Gly Lys Glu Met 115 120 125 Gly Leu Asn Val Glu Leu Gln Ile Asn Pro Glu Val Lys Asp Phe Phe 130 135 140 Thr Phe Lys Ser Ile Ser Thr Thr Asn Lys Gln Arg Cys Phe Leu Ser 145 150 155 160 Leu His Gly Glu Thr Arg Glu Ile Leu Cys Asp Asp Lys Leu Tyr Asn 165 170 175 Val Leu Leu Ala Val Phe Asn Ser Tyr Asp Pro Asn Asp Leu Leu Lys 180 185 190 His Ile Ser Thr Ile Glu Ser Leu Lys Lys Ile Phe Tyr Thr Ile Thr 195 200 205 Cys Glu Ala Val Tyr Leu 210 INFORMATION FOR SEQ ID NO:664: SEQUENCE CHARACTERISTICS: LENGTH: 78 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...78 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:664 Val Gly Gly Ile Val Ala Asn Met Asn Asp Leu Ser Thr Tyr Met Val 1 5 10 Glu Asn Leu Leu Met Gly Leu Tyr Leu Phe Ser Ser Ala Leu Asp Leu 25 Gly Val Lys Lys Ala Ile Asn Leu Ala Ser Ser Cys Ala Tyr Pro Lys 40 Tyr Ala Pro Asn Pro Leu Lys Glu Ser Asp Leu Leu Asn Gly Ser Leu 55 Glu Pro Thr Asn Glu Gly Tyr Ala Leu Pro Asn Ser Leu Unk 70 INFORMATION FOR SEQ ID NO:665: SEQUENCE CHARACTERISTICS: LENGTH: 177 amino acids A OrBDIMl If f'r S9 6/096 0912 2 S1 8 DEC1996 554 TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...177 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:665 Met Lys Lys Arg Lys His Val Ser Lys Lys Val Phe Asn Val Ile Ile 1 5 10 Leu Phe Val Ala Val Phe Thr Leu Leu Val Val Ile His Lys Thr Leu 25 Ser Asn Gly Ile His Ile Gln Asn Leu Lys Ile Gly Lys Leu Gly Ile 40 Ser Glu Leu Tyr Leu Lys Leu Asn Asn Lys Leu Ser Leu Glu Val Glu 55 Arg Val Asp Leu Ser Ser Phe Phe His Gln Lys Pro Thr Lys Lys Arg 70 75 Leu Glu Val Ser Asp Leu Ile Lys Asn Ile Arg Tyr Gly Ile Trp Ala 90 Val Ser Tyr Phe Glu Lys Leu Lys Val Lys Glu Ile Ile Leu Asp Asp 100 105 110 Lys Asn Lys Ala Asn Ile Phe Phe Asp Gly Asn Lys Tyr Glu Unk Arg 115 120 125 Ile Ser Arg Asn Gln Arg Gly Ile Phe Pro Arg Arg Arg Leu Lys Ile 130 135 140 Ser Ser Leu Lys Ser Ser Ile Cys Phe Leu Lys Met Leu Lys Ser Lys 145 150 155 160 Trp Met Ala Thr Pro Thr Ile Unk Pro Lys Pro Gly Lys Trp Arg Ser 165 170 175 Ile INFORMATION FOR SEQ ID NO:666: SEQUENCE CHARACTERISTICS: LENGTH: 258 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...258 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:666 Val Ser Cys Trp Gly Ala Ser Lys Lys Arg Phe Leu Gly Phe Cys Val 1 5 10 Trp Gly Arg Cys Val Tyr Ala Gly Gly Leu Met Ala Glu Gln Asp Pro PCT/US 96/ 0 9 122 IPEA/US 18 DEC1996 Lys Glu Leu Ile Phe Ser Gly Ile Thr Asp Ala Ala Leu Tyr Ser 145 Lys Gly Lys Asn Lys 225 Ser Lys Arg Gly Arg Thr Ala Tyr 130 Ala Asp Cys Asp Asp 210 Gly Cys Gin Ala Cys Glu Ala Glu 115 Ser Thr Leu Ser Phe 195 Ala Val Lys Lys Ala Asn Lys 100 Phe Lys Phe Glu Lys 180 Lys Lys Ala Leu Lys Ile Ala Val Tyr Ser Tyr Tyr 165 Leu Lys Gly Lys Gly 245 40 Glu Glu Ser Leu Val 120 Leu Met Lys Asp Glu 200 Ala Lys Thr Lys Val Ile Asn 105 Asn Asn Ile Ala Tyr 185 Tyr Leu Gin Ile Ala Tyr Glu 90 Asp Asp Asn Lys Cys 170 Phe Ser Ala Thr Cys 250 Tyr Cys Ser 75 Lys Ala Leu Val Gly 155 Glu Phe Ala Ala Thr 235 Thr Lys Ser Ala Glu Lys Glu 140 Leu Leu Gly Lys Phe 220 Glu Asp Ser Gly Leu Lys Asn 125 Gly Lys Asn Glu Ala 205 Tyr Asn Asn Asp Ala His Lys Leu Met Asp Gly 175 Val Glu Glu Glu Phe Ala Ile Thr Asp Glu Leu Lys 160 Gly Thr Leu Gly Lys 240 Leu Lys Glu Ala Asp Ile Leu Lys Glu Gin 255 INFORMATION FOR SEQ ID NO:667: SEQUENCE CHARACTERISTICS: LENGTH: 75 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...75 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:667 Ala Leu Thr Leu Gly Ala Arg Gly Gly Val 5 10 Ile Pro Arg Phe Ile Asp Tyr Phe Lys Thr 25 Phe Glu Thr Lys Gly Arg Met Gly Ala Phe 40 His Val Val Met Lys Lys Thr Pro Gly Leu 55 Leu Glu Asn Tyr Leu Leu His Asp Arg Ile 70 Val 1 Ile Arg Val Ala Tyr Leu Cys Gly Gly Ser Pro Phe Arg Ala Leu Ala Ser Ile Pro Asp Gly Ala Gly Ile 19 AMEKDED ShEgj PCTUS 96/0912a IPENIUS 18 DEC 1996 INFORMATION FOR SEQ ID NO:668: SEQUENCE CHARACTERISTICS: LENGTH: 421 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .421 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:668 Met 1 Cys Pro Ser Asn Ile Asn Lys Asn 145 Gly Ile Ser Asn Glu 225 Asn Val1 Lys Asp Glu 305 Lys Leu Leu Lys Gly Leu Thr Met Lys Lys Leu Val Phe Ser Lys Glu Ile Gin Ser Ala Gin Leu 130 Lys Giu Sen Gly Tyr 210 Gin Lys Leu Gin Pro 290 Gin Asp Leu Asn Ser Thr Lys Leu Ser Gin Sen 115 Gin Ile Gin Gly Arg 195 Glu Lys Gin Gin Gly 275 Ile Giu Ala Thr Gin Val1 His Arg Gin Sen Tyr 100 Ile Gin Val1 Thr Ser 180 Ala Sen Arg Leu Thr 260 Ile Lys Ile Gin Leu 340 Thr 5 Phe Val1 Tyr Lys Ala Gin Giu Gin Asn Gin 165 G ly Trp Glu Arg Lys 245 Glu His Asn Gin Ser 325 Lys Met Ala Glu Sen Gin Giu Glu 55 Val Asn 70 Ile Thr Ile Glu Asn Trp Cys Pro 135 Leu Lys iso Thr Ala Tyr Gly Gly Giu Gin Ala 215 Phe Leu 230 Asp Lys Phe Gly Tyr Cys Val Phe 295 Thr Leu 310 Gin Ala Tyr Leu Ala Met Gly Ala 40 Ile Asn Leu Ser Asn 120 Trp Asp Ang Asn Met 200 Leu Leu Leu Val1 Thn 280 Ang Thr Tyr Lys Gin Giu 25 Thr Ile Met Ala Ile 105 Ala Leu Leu Asp Met 185 Leu Leu Arg Asp Thr 265 Giu Thr Leu Ala Giu 345 Ser 10 Thr Ile Ser Ile As n 90 Arg Gin Asn Asn Val1 170 Gin Cys Ala Val1 Pro 250 Asp Asn Thr Asp As n 330 Ile Glu Pro Ile Lys As n 75 Pro Tyr As n Val1 Asn 155 Gin Sen Lys Thr Lys 235 Phe Pro Lys Ang Leu 315 Phe Thr Ile Leu Gly Ala Thr Met Asn Leu As n 140 Leu Asn Leu Met Gly 220 Lys Leu Thr Giu Leu 300 Ile As n As n Met Met Ile Lys Gln Thr Gin Tyr Leu 125 Ala Ile Leu Ala Val1 205 As n Lys Lys Ala Thr 285 Asp Lys Gin Gin Thr Leu Val1 Met Ala Asn Val1 Giu 110 Arg Leu Thn Ile Gly 190 Asn Asn Val Arg Asn 270 Giy Asn Ala Ang Met 350 Asp Leu As n Val1 Gin Ser Leu Asn As n Thr Lys Gin 175 Giu Asp Pro Asn Leu 255 His Lys Glu Ser Ile 335 Leu Asp Cys Asp Asp Val1 Leu Gln Leu Lys Asn Asn 160 Ser Leu Ser Giu Asp 240 Asp Asn Cys Leu Asn 320 Lys Phe Tyr y ANIEN-DED SHET Phe Glu 385 Tyr Phe PCT/US 96/09122 IPEA/US 18 DE C 996 557 355-. 360 365 Gin Asn Asn Asp Gly Phe Gly Glu Lys Glu Asn His Ile Asp 375 380 Leu Thr Gln Lys Arg Ile Asn Glu Arg Glu Arg Ala Arg Ile 390 395 400 Gin Asn Pro Asn Val Lys Phe Asp Gln Phe Gly Phe Pro Ile 405 410 415 Ile Trp Asp 420 INFORMATION FOR SEQ ID NO:669: SEQUENCE CHARACTERISTICS: LENGTH: 81 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...81 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:669 Met Ser Val Asn Leu Leu Glu Leu Leu Lys Leu Ala Val Pro Leu 1 5 10 Val Ile Leu Ser Val Gln Val Ala Val Met Ile Leu Tyr Val Val 25 Val Thr Phe Arg Val Cys Gly Lys Asp Tyr Asp Ala Ala Val Leu 40 Ala Gly His Cys Gly Phe Gly Leu Gly Ala Thr Pro Thr Ala Met 55 Asn Met Gln Thr Ile Thr Asn His Tyr Gly Pro Ser His Val Ala 70 Ile INFORMATION FOR SEQ ID NO:670: SEQUENCE CHARACTERISTICS: LENGTH: 112 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...112 0 L (xi) SEQUENCE DESCRIPTION: SEQ ID NO:670 T o AMENDED S 1
EET
PCTUS 96/0912a.
1PEANJS 18 D E C1996 Met Ile Phe Glu Asp Pro Gin Gin T'yr Ile Giu Ala Lys His Leu. Ser Pro Giu Vai Met Ile Ser Trp Phe Arg Phe Val Phe 100 Pro Lys Val1 Ile Val1 Gly Ile Leu Lys Phe Ser Lys 70 Phe Leu Gin Thr Leu Tyr 55 Ile Lys Pro Ser Arg Val1 40 Asn Ala Ile His Ala Leu 10 Ser Phe 25 Leu Aia Giu Aia Gin Lys Ala Phe 90 Arg Ala 105 558 Leu T, Asp Lo Leu G.
Lys A.
6( Ser Vi 75 Phe A! Lys Asc Phe Ser Leu Phe Ala Arg Phe Arg Asp Leu Phe Ile Ser Lys 110 Tyr Phe Leu Ile Met Ser Tyr Ser Leu Arg Arg His Lys Ala INFORMATION FOR SEQ ID NO:671: SEQUENCE CHARACTERISTICS: LENGTH: 325 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc-feature LOCATION .325 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:67i 1Leu Ala Gly Leu Unk Val Giy Cys Unk Arg Met Lys Unk Trp Phe Ala Lys Gly Ala Tyr Val1 145 Thr Ile As n Thr Ser Leu Tyr Thr Asn As n Gly Thr Pro 130 Asn His Asn Aia Cys 210 Gly Ser Ala Gly Tyr Asp Giu Phe 11S As n Asn Thr Ser As n 195 Unk Pro Trp Ile Asn Tyr Asn Tyr 100 Asn Gly Ser Gly As n 180 Sen Ser Ser Gly Trp Gin His Giy Asn Leu His Val1 Thr 165 Ile Val1 Leu Tyr Ser Asp 40 Thr Asn Phe Asn Ser 120 Val1 Gly Leu Tyr Ile 200 Val1 Lys Cys Giu Ala Ile Leu Glu Ser Ala 140 Giy Ala Gin Ser Aia 220 Asn Gin Val1 Lys Gly Thr Tyr Leu Phe 125 Gly Ser Asn Val1 Leu 205 Asn Ala Thr His Thr Gly Ala Asn Cl 110 Thr Thr Giy Lys Asn 190 Asn Cys Thr Phe Trp Arg Pro Gin Gin Asn Aia Asn Leu Tyr Thr Ser Asn Ser Trp Ile Asn Ala Giy 160 Val Thr 175 Val Gly Gly Giu Ser Thr Asn Thr 1/Mi E I0E D S I i EET PCT/US 96/09 1 2 IPENUAAJS 18 DEC1996 559 225 230 235 240 Thr Phe Ser Unk Ser Ser Gly Ser Phe Thr Phe Glu Glu Asn Ala Thr 245 250 255 Phe Ser Gly Ala Lys Leu Asn Gly Gly Ala Phe Thr Phe Asn Lys Lys 260 265 270 Phe Asn Ala Thr Asn Asn Thr Ala Phe Asn Ser Gly Ser Phe Thr Phe 275 280 285 Lys Gly Thr Ser Ser Phe Asn Gly Ala Asn Phe Ser Asn Ala Ser Tyr 290 295 300 Thr Phe Asn Asn Gln Ala Thr Phe Gln Asn Ser Ser Phe Asn Gly Gly 305 310 315 320 Thr Phe Thr Phe Asn 325 INFORMATION FOR SEQ ID NO:671: SEQUENCE CHARACTERISTICS: LENGTH: 325 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...325 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:671 Leu Ala Gly Leu Unk Val Gly Cys Unk Arg Met Lys Gln Thr Phe Trp 1 5 10 Unk Leu Ser Trp Gly Glu Lys Ser Gln Lys Val Cys Val His Arg Pro 25 Trp Tyr Ala Ile Trp Ser Cys Asp Lys Trp Glu Glu Lys Thr Gln Gin 40 Phe Thr Gly Asn Gln Leu Ile Thr Lys Thr Trp Ala Gly Gly Asn Ala 55 Ala Asn Tyr Tyr His Ser Gln Asn Asn Gln Asp Ile Thr Ala Asn Leu 70 75 Lys Asn Asp Asn Gly Thr Tyr Phe Leu Ser Gly Leu Tyr Asn Tyr Thr 90 Gly Gly Glu Tyr Asn Gly Gly Asn Leu Asp Ile Glu Leu Gly Ser Asn 100 105 110 Ala Thr Phe Asn Leu Gly Ala Ser Ser Gly Asn Ser Phe Thr Ser Trp 115 120 125 Tyr Pro Asn Gly His Thr Asp Val Thr Phe Ser Ala Gly Thr Ile Asn 130 135 140 Val Asn Asn Ser Val Glu Val Gly Asn Arg Val Gly Ser Gly Ala Gly 145 150 155 160 Thr His Thr Gly Thr Ala Thr Leu Asn Leu Asn Ala Asn Lys Val Thr 165 170 175 Ile Asn Ser Asn Ile Ser Ala Tyr Lys Thr Ser Gln Val Asn Val Gly 180 185 190 Asn Ala Asn Ser Val Ile Thr Ile Asn Ser Val Ser Leu Asn Gly Glu 195 200 205 Thr Cys Unk Ser Leu Ala Arg Val Gly Val Gly Ala Asn Cys Ser Thr 210 215 220 Ser Gly Pro Ser Tyr Ser Phe Lys Gly Thr Thr Asn Ala Thr Asn Thr 225 230 235 240 AMENDED
SH!EET
PCT/t6h 96/09122 IPEANS 18 DEC 1996 Thr Phe Phe Lys Thr 305 Thr Ser dly Ala 275 Thr Asn Thr Unk Ala 260 Thr Ser As n Phe Ser Gly Ser Phe Thr 250 Leu.Asn Gly Gly Ala 265 Asn Thr Ala Phe Asn 280 Phe Asn Gly Ala Asn 295 Ala Thr Phe Gin Asn 310 Giu Giu Asn Thr Phe Asn 270 Gly Ser Phe 285 Ser Asn Ala 300 Ser Phe Asn Thr Lys Phe Tyr G ly 320 INFORMATION FOR SEQ ID NO:672: SEQUENCE CHARACTERISTICS: LENGTH: 271 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .271 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:672 1Leu Leu Ser Leu Val Lys Gly Lys Thr Met Leu Arg Ser Leu Ala Asn Asp Thr Val Glu Gin Phe Leu 145 Gly Asn Leu Asp Gin 225 Thr As n Phe Ser Arg Thr Val1 Lys 130 Ile Val1 Val1 His Ala 210 Gly Ser I le Asn Asn Pro Giu Gin Leu Pro Asp Ile Ser 195 Ile Phe Gly Ala Asp Thr Ser Asn 100 Leu Asp Gin Gly Gly 180 Met Val1 Leu Met Asn Leu Thr Ala Asn Pro Giu Ile Thr 165 Gin Giy Gly Glu Leu Val1 Phe Leu 70 Ile Leu Asp Gin Thr 150 Val1 Ile Asp As n Leu Ala Asn Tyr 55 Ser Thr Asp Gly Gly 135 Leu Ser Thr As n Pro 215 Ser Gin Thr 40 Gin Pro Lys Ile Thr 120 Asn Pro Val1 Leu Leu 200 Asp Asn Gin 25 Thr Ala Asp Met Ala 105 Thr Leu Glu Thr Ala 185 Phe Sen Val1 10 Thr Gly Met Gly Phe 90 Ile Ala Val1 Asp Gin 170 As n Se r Gin Arg His Phe Gin Met 75 Ser Thr Tyr Thr Thr 155 Gly Phe Ile Giy Leu 235 Ala I le Lys Tyr Giu Gin G iy Thr Ser 140 Thr Leu Val1 Thr Leu 220 Val1 Asi, Asp Lys Ala Val1 Giy Lys Arg 125 Giu Gin Gin Asn Asn 205 Gly Giu Ser Thr Ser Gly Giy Sen G iy 110 Ser Gly Val1 Thr Pro 190 Ala *Lys Giu *Lys Tyr rhr Arg Thn Leu Pro Phe Gly Tyr Asn Thr 175 Ala Ser Le2 Met Sei Ser Ser Ala As n G ly Lys Phe Asn Leu Ile 160 Ser *Gly *Gly Arg *Thr 240 Sle 230 Asp Leu Ile Thr Ala Gln Arg Ala Tyr Giu PCT/US 96/09 122 561PEN S 18 DEC1996 245 250 255 Gin Thr Ala Asp Ala Met Leu Gln Thr Val Asn Ser Leu Lys Arg 260 265 270 INFORMATION FOR SEQ ID NO:672: SEQUENCE CHARACTERISTICS: LENGTH: 271 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION 1...271 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:672 Leu Leu Ser Leu Val Lys Gly Lys Thr Met Leu Arg 1 Ala Asn Asp Thr Val Glu Gin Phe Leu 145 Gly Asn Leu Asp Gin 225 Asp Gin Thr Asn Phe Ser Arg Thr Val Lys 130 Ile Val Val His Ala 210 Gly Leu Thr Ser Ile Asn Asn Pro Glu Gin 115 Leu Pro Asp Ile Ser 195 Ile Phe Ile Ala Gly Ala Asp Thr Ser Asn 100 Leu Asp Gin Gly Gly 180 Met Val Leu Thr Asp 260 5 Met Asn Leu Thr Ala Asn Pro Glu Ile Thr 165 Gin Gly Gly Glu Ala 245 Ala Leu Val Phe Leu 70 Ile Leu Asp Gin Thr 150 Val Ile Asp Asn Leu 230 Gin Met Gin Thr Gin Pro Lys Ile Thr 120 Asn Pro Val Leu Leu 200 Asp Asn Ala Gin Gin 25 Thr Ala Asp Met Ala 105 Thr Leu Glu Thr Ala 185 Phe Ser Val Tyr Thr 265 10 Thr Gly Met Gly Phe 90 I le Ala Val Asp Gin 170 Asn Ser Gin Arg Glu 250 Val Leu Thr Ser Gly Gly Ser Gly 110 Ser Gly Val Thr Pro 190 Ala Lys Glu Lys Lys 270 Tyr Thr Arg Thr Leu Pro Phe Gly Tyr Asn Thr 175 Ala Ser Leu Met Ser 255 Arg Ser Ser Ala Asn Gly Lys Phe Asn Leu Ile 160 Ser Gly Gly Arg Thr 240 Ile INFORMATION FOR SEQ ID NO:673: SEQUENCE CHARACTERISTICS: LENGTH: 78 amino acids AMENDED SHEE
T
PCT/US 96/09122 562 IPENUS 18 DEC 1996 TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...78 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:673 Val Tyr Ala Leu Met Val Ala Phe Phe Ala Tyr Met Ser Tyr Cys Leu 1 5 10 Gly Tyr Gln Phe Ser Lys Phe Val Ser Lys Asn Asn Ile Ser Ser Leu 25 Ser Ser Leu Leu Ser Ser Cys Val Arg Val Val Ser Val Leu Ile Leu 40 Ser Leu Ser Ser Leu Glu Leu Arg Tyr Phe Ser Pro Leu Thr Ile Ile 55 Thr Met His Phe Ala Leu Thr Leu Ile Ile Leu Phe Phe Phe 70 INFORMATION FOR SEQ ID NO:674: SEQUENCE CHARACTERISTICS: LENGTH: 400 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...400 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:674 Met Arg Ser Trp Met Lys Lys Lys Tyr Phe Thr Leu Leu Leu Gin Ser 1 5 10 Ser Val Val Leu Ala Val Phe Ile Gly Cys Ser Ser Thr Arg Asn His 25 Thr Phe Ser Ala Leu Ser Asn Gin Glu Asn Thr Asp Asp Lys Leu Pro 40 Val Val His Ser Ile Lys Thr Ile Asn Asp Val Ser Ser Val Gly Phe 55 Glu Trp Ser Lys Val Ala Asp Thr Tyr Asp Ile Asp Gly Phe Val Leu 70 75 Tyr Arg Leu Lys Lys Asp Ser Lys Leu Lys Arg Ile Ala Thr Ile Lys 90 Asn Pro Tyr Ala Thr His Tyr Tyr Asp Glu Gly Leu Glu Thr Glu Ser 100 105 110 Ser Tyr Thr Tyr Gin Leu Ala Thr Tyr Lys Gly Asp Lys Ile Ser Lys 115 120 125 Leu Ser Glu Pro Ile Leu Val Lys Thr Ser Phe Ile Asn Pro Val Glu PCT/US 96/09 122 IPEA/US 18 DEC 1996 Ser 145 Ser Asn Phe Tyr Val 225 Val Lys Asn Tyr Val 305 Ala Gly Ser Lys Lys 385 130 Val Pro Lys Val Gin 210 Ile Arg Ser Arg Val 290 Ala Met Thr Pro Thr 370 Asp Phe His Asp Glu 195 Ile Val Val Pro Asn 275 Asp Val Gly Ile Lys 355 Pro let Ala Pro Gly 180 Phe Ile Glu Ser Glu 260 Asp Lys Asp Glu Gin 340 Ile Leu Lys Ser Asn 165 Lys Phe Ala Gly Gin 245 Glu Lys Ile Lys Thr 325 Asp Ala Arg Val Leu 150 Pro Phe Asp Glu Lys 230 Asn Asp Tyr Glu Thr 310 Ser Ser Thr Phe Gly 390 135 Glu Ser Leu Lys Asn 215 Thr Leu Val Lys Lys 295 His Asp Ser Tyr Gly 375 Val Tyr Pro Lys Ser Val Asn Asp 200 Phe Lys Thr Ile Phe 280 Asp Leu Arg Ala Ala 360 Asn Ser Val 185 Leu Met Asp Arg Ala 265 Ile Asn Glu Pro Leu 345 Val Ile Lys 170 Gly Glu Gly Leu Gin 250 Tyr Ala Leu Gly Glu 330 Ile Tyr Thr 155 Tyr Ala Asp Asp Pro 235 Ile Arg Gin Thr Ala 315 Ala Gin Arg Gin 140 Val Ile Val Gly Lys 220 Lys Glu Ile Thr Arg 300 Leu Pro Trp Phe Asn 380 Lys Val Phe Trp Ile Lys Gin 205 Ser Glu Leu Tyr Thr 285 Tyr Pro Ile Glu Glu 365 G1n Gin Asn 190 Lys Arg Ile Ser Ala 270 Asn Tyr Lys Ile.
Asn 350 Ala Phe Arg 175 Arg Tyr Pro Ala Trp 255 Ser Thr Lys Glu Thr 335 Asn Asn Val 160 Gin Leu Arg Ser Asn 240 Asp Asn Ser Val Pro 320 Lys Pro Ser Asp Ala Tyr Arg Tyr Gin Val Val Ser Val INFORMATION FOR SEQ ID NO:675: SEQUENCE CHARACTERISTICS: LENGTH: 90 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...90 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:675 Met Gln Asn Gly Tyr Tyr Ala Ala Thr Gly Ala Met Ala Thr Gin 1 5 10 Asn Arg Leu Asp Leu Thr Ser Asn Asn Leu Ala Asn Leu Asn Thr 25 Gly Phe Lys Arg Asp Asp Ala Ile Thr Gly Asp Phe Leu Arg Leu 40 Gin Glu Tyr Arg Glu Gin Leu Pro Leu Glu Asp Gin Thr Lys Ala 55 Ala Lys Tyr Leu Asn Arg Unk Leu Asn Arg Val Pro Ile Leu Ser 70 75 Phe Asn Tyr Ser Unk
K.
1 1 PCT/US 96/09122 IPENUS 18 DEC1996 564 Ile Tyr Thr. Unk Arg Unk Leu Gly Unk Val INFORMATION FOR SEQ ID NO:675: SEQUENCE CHARACTERISTICS: LENGTH: 90 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...90 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:675 Met Gin Asn Gly Tyr Tyr Ala Ala Thr Gly Ala Met Ala Thr Gin Phe 1 5 10 Asn Arg Leu Asp Leu Thr Ser Asn Asn Leu Ala Asn Leu Asn Thr Asn 25 Gly Phe Lys Arg Asp Asp Ala Ile Thr Gly Asp Phe Leu Arg Leu Tyr 40 Gin Glu Tyr Arg Glu Gin Leu Pro Leu Glu Asp Gin Thr Lys Ala Ser 55 Ala Lys Tyr Leu Asn Arg Unk Leu Asn Arg Val Pro Ile Leu Ser Unk 70 75 Ile Tyr Thr Unk Arg Unk Leu Gly Unk Val INFORMATION FOR SEQ ID NO:676: SEQUENCE CHARACTERISTICS: LENGTH: 126 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...126 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:676 Met Leu Pro Thr Lys Thr Arg Ile Arg Asp Pro Asn Lys Gin Glu Leu 1 5 10 Thr Gln Pro Lys Ile Lys Gly Leu Ser Met Gly Lys Ile Leu Ala Ser 25 Leu Leu Gly Gly Gly Thr Asn Leu Phe Thr Gly Leu Ser Ser Asp Leu 40 Phe Ser Met Ile Leu Asn Phe Leu Phe Phe Leu Met Leu Met Met Gly P T/US 96/0912 2 I NUS18D.39S Leu Lys Asn Asp Asn Asn Met Lys 565 55 Glu Ala Leu Gly Lys Lys Phe Asn Leu Pro 70 75 Phe Met Ala Glu Val Leu Lys Asn Gly Phe 90 Gly Ser Ala Leu Val Gly Asn Gly Phe Gly 100 105 Thr Thr Asn Lys Met Ser Val Pro Gln Val 115 120 Asp Asn Ile Ser Ile Lys Ser Lys Ser 110 Leu INFORMATION FOR SEQ ID NO:677: SEQUENCE CHARACTERISTICS: LENGTH: 195 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...195 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:677 Val Gly Ala Met Pro Thr Ile Gln Ile Arg Unk 1 Ser Gly Tyr Met Phe Gin Gin Tyr Pro Ile Trp Ala Gly Asp Thr Tyr 130 Arg Lys 145 Leu Val Ala Met Gin Pro His Ala Ala Gly Pro Lys Pro 115 Val Leu Phe Gly Gly 195 Ser Pro Ile Pro Asn Ala 100 Ser Arg Thr Gin Leu 180 5 Asp Tyr Asp Asn Gin Arg Phe Ser Gly Thr 165 Lys Ala Ala Arg Thr 70 Trp Asn Ile Gly Leu 150 Ile Pro Thr Leu His Ile 40 Ile Asp 55 Tyr Gly Glu Asn Ala Gly Lys Ser 120 Gly Met 135 Glu Ala Gly Trp Ile Thr Met 25 Glu Val Gly Gin Phe 105 Leu Ile Lys Met Asn 185 10 Leu Leu Ile Ile Ala 90 Ala Gly Asn Ala Gly 170 Val Asp Lys Val 75 Ala Ala Asn Lys Leu 155 Ser Phe Asn Ile Gly Asn Glu Pro Asn His 140 Gly Met Gly Gly Phe Gly Ile Arg Unk Leu 125 Val Thr Thr Ala Ile Pro Gly Ile Unk Asp 110 Leu Gly Ile Ser Gly Pro Val Ser Thr Thr Lys Tyr Ile Ala Met 175 Gly Val Thr Val Lys Tyr Thr Asn Gin Pro 160 Lys Thr Thr Ile Leu Ala Ile Unk INFORMATION FOR SEQ ID NO:677: SEQUENCE CHARACTERISTICS: LENGTH: 195 amino acids TYPE: amino acid TOPOLOGY: linear PCT/US 96/09122 IPEMUS 18 DEC1996 566 (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...195 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:677 Val Gly Ala Met Pro Thr Ile Gin Ile Arg Unk Phe Gly Ala Gly Gly 1 5 10 Ser Gly His Ser Asp Ala Thr Leu Met Leu Val Asn Gly Ile Pro Val 25 Tyr Met Ala Pro Tyr Ala His Ile Glu Leu Asp Ile Phe Pro Val Thr 40 Phe Gin Ala Ile Asp Arg Ile Asp Val Ile Lys Gly Gly Gly Ser Val 55 Gin Tyr Gly Pro Asn Thr Tyr Gly Gly Ile Val Asn Ile Ile Thr Lys 70 75 Pro Ile Pro Asn Gin Trp Glu Asn Gin Ala Ala Glu Arg Unk Thr Tyr 90 Trp Ala Lys Ala Arg Asn Ala Gly Phe Ala Ala Pro Unk Asp Lys Thr 100 105 110 Gly Asp Pro Ser Phe Ile Lys Ser Leu Gly Asn Asn Leu Leu Tyr Asn 115 120 125 Thr Tyr Val Arg Ser Gly Gly Met Ile Asn Lys His Val Gly Ile Gin 130 135 140 Arg Lys Leu Thr Gly Leu Glu Ala Lys Ala Leu Gly Thr Ile Ala Pro 145 150 155 160 Leu Val Phe Gln Thr Ile Gly Trp Met Gly Ser Met Thr Ser Met Lys 165 170 175 Ala Met Gly Leu Lys Pro Ile Thr Asn Thr Thr Ile Leu Ala Ile Unk 180 185 190 Gin Pro Gly 195 INFORMATION FOR SEQ ID NO:678: (i).SEQUENCE CHARACTERISTICS: LENGTH: 72 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...72 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:678 Met Ala Asn Met Met Met Ala Ala Ala Met Leu Gly Ile Asp Ser Cys 1 5 10 Pro Ile Glu Gly Tyr Asp Gin Glu Lys Val Glu Ala Tyr Leu Glu Glu I q 1"Simpm 0 PCT/US 96/Oq 0 12.
IPENUS 1 r 567 25 Lys Gly Tyr Leu Asn Thr Ala Glu Phe Gly Val Ser Val Met Ala Ser 40 Phe Gly Tyr Arg Asn Gln Glu Ile Thr Pro Lys Thr Arg Trp Lys Thr 55 Glu Val Ile Tyr Glu Val Ile Glu INFORMATION FOR SEQ ID NO:679: SEQUENCE CHARACTERISTICS: LENGTH: 111 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...111 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:679 Met Ala Gly Leu Val Leu Met Val Leu Leu Ala Ser Tyr Glu Ser Phe 1 5 10 Val Ser Lys Leu Asp Lys Val Asp Ala Ser Glu Ile Thr Trp Leu Lys 25 His Thr Asp Phe Asn Ala Leu Lys Leu Lys Val Ser Leu Ser Ile Val 40 Ala Ile Ser Ala Ile Phe Leu Leu Lys Arg Tyr Met Ser Leu Glu Asp 55 Val Leu Ser Ser Ile Pro Lys Asp Thr Pro Leu Ser His Asn Pro Ile 70 75 Phe Trp Gln Val Val Ile His Leu Val Phe Val Cys Ser Ala Leu Leu 90 Thr Ala Val Thr Asn Asn Ile Ala Phe Ser Gln Lys Glu Arg His 100 105 110 INFORMATION FOR SEQ ID NO:680: SEQUENCE CHARACTERISTICS: LENGTH: 142 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...142 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:680 AMENDED SHFT PCT/US 9 6 0q 122 I AMS e3 DEC a 568 Met Ile Thr-Ile Val Ile Ala Lys Ala Gly Asn Ile Val Lys Unk Asp 1 5 10 Ile Phe Thr His Ile Ser Asp Ile Lys Met Gly Leu Ile Lys Gly Gly 25 Gin Trp Gly Val Ile Gly Leu Gly Asn Ile Gly Lys Arg Val Ala Lys 40 Leu Ala Gin Ala Phe Gly Ala Lys Val Val Tyr Phe Ser Pro Lys Asp 55 Lys Lys Glu Glu Tyr Glu Arg Leu Ser Leu Glu Glu Leu Leu Lys Thr 70 75 Ser Gly Ile Ile Ser Ile His Ala Pro Leu Asn Glu Ser Thr Arg Asp 90 Leu Ile Ala Leu Lys Glu Leu Gin Ser Leu Lys Asp Gly Ala Ile Leu 100 105 110 Ile Asn Val Gly Arg Gly Gly Ile Val Asn Glu Lys Unk Leu Ala Unk 115 120 125 Unk Leu Glu Thr Thr Asp Leu Tyr Tyr Ala Ser Asp Val Phe 130 135 140 INFORMATION FOR SEQ ID NO:681: SEQUENCE CHARACTERISTICS: LENGTH: 63 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...63 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:681 Val Asn Phe Asn Ala Lys Asn Ile Ser Ile Asp Asn Leu Val Glu Ile 1 5 10 Asn Asn Arg Val Gly Ser Gly Ala Gly Arg Lys Ala Ser Ser Thr Val 25 Leu Thr Leu Gln Ala Ser Glu Gly Ile Thr Unk Ser Lys Asn Ala Glu 40 Ile Ser Leu Tyr Asp Gly Ala Thr Unk Ile Trp Leu Gln Thr Gly 55 INFORMATION FOR SEQ ID NO:682: SEQUENCE CHARACTERISTICS: LENGTH: 310 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori I\ (ix) FEATURE: A R-ftR ^4 PCT/US 9 6/0q12? IPENMS 18 DEC i996 NAME/KEY: misc_feature LOCATION 1...310 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:682 Met Arg Thr Leu Ile Leu Ser Leu Leu 1 Met Ser Ile Lys Ile Gly Asp Val Lys 145 Asp Gin Cys Thr His 225 Gly Glu Val Asn Ile 305 Leu Ala Lys Lys Val Leu Leu Ser 130 Glu Leu Thr Gly Ser 210 Glu Leu Cys Leu Leu 290 Ser Leu Asn Lys Asn Gly Cys Glu 115 Val Val Ala Gly Leu 195 Phe Phe Leu Gly Val 275 Thr Pro Lys His Phe Leu Pro Glu 100 Ile Ser Ser Asn Phe 180 Leu Ser Ile Gin Leu 260 Tyr Ala Tyr 5 Glu Cys Gin Glu Tyr Val Leu Ala Ser Phe 165 Tyr Gly Ala Asp Phe 245 Asp Gly Ser Asp Lys Ala Gly Lys Ser Pro 105 Leu Val Glu Ala Lys 185 Asp Ile Leu Ala Lys 265 Leu Val Lys Leu Gly Val Asp Asn Leu Lys Thr Tyr Asn 170 Leu Leu Lys Arg Leu 250 Lys Pro Val His Ala Ile Lys Arg Ser Tyr Gly Ala Cys Ile Pro Met Ala Leu 75 Glu Val Ser Asn Glu His Lys Thr Pro 125 Gly Ile Leu 140 Arg Ala Ile 155 Pro Lys Asp Leu Gly Gly Ile Asp Thr 205 Tyr Ala Asn 220 Glu Glu Phe 235 Ala Tyr Gin Glu Asn Asn Ala Ile Asn 285 Thr Phe Asn 300 Gly Leu Ala Thr Val Glu Leu Leu Leu Leu 160 Tyr Gly Pro Arg Pro 240 Asp Arg Gly Gly INFORMATION FOR SEQ ID NO:683: SEQUENCE CHARACTERISTICS: LENGTH: 169 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...169 AMENDED SHEET, PQT/US 96/O912 1 18DEC 1996 570 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:683 Val Ala Cys Asn Thr Ala Ser Ala Leu Ala Leu Glu Glu Met Gln Lys 1 5 10 Tyr Ser Lys Ile Pro Ile Val Gly Val Ile Glu Pro Ser Ile Leu Ala 25 Ile Lys Arg Gin Val Glu Asp Lys Asn Ala Pro Ile Leu Val Leu Gly 40 Thr Lys Ala Thr Ile Gin Ser Asn Ala Tyr Asp Asn Ala Leu Lys Gin 55 Gin Gly Tyr Leu Asn Ile Ser His Leu Ala Thr Ser Leu Phe Val Pro 70 75 Leu Ile Glu Glu Ser Ile Leu Glu Gly Glu Leu Leu Glu Thr Cys Met 90 His Tyr Tyr Phe Thr Pro Leu Glu Ile Leu Pro Glu Val Ile Ile Leu 100 105 110 Gly Cys Thr His Phe Pro Leu Ile Ala Gin Lys Ile Glu Gly Tyr Phe 115 120 125 Met Gly His Phe Ala Leu Pro Thr Pro Pro Leu Leu Ile His Ser Gly 130 135 140 Asp Ala Ile Val Glu Tyr Leu Gln Gin Lys Tyr Ala Leu Lys Asn Asn 145 150 155 160 Ala Cys Thr Phe Pro Lys Val Glu Phe 165 INFORMATION FOR SEQ ID NO:684: SEQUENCE CHARACTERISTICS: LENGTH: 84 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...84 SEQUENCE DESCRIPTION: SEQ ID NO:684 Met Arg Unk Glu Lys Ile Met Thr Asn Phe Glu Lys Unk Ile Ala Gin 1 5 10 Asn Arg Leu Lys Thr Asn Ala Val Leu Thr Thr Tyr Cys Ala Ile Phe 25 Ala Phe Ile Gly Leu Leu Val Asp Ala Ile Arg Ile Asn Ala Asn Asp 40 Leu Gly Ile Ala Leu Phe Lys Leu Met Thr Phe Gin Ile Phe Pro Thr 55 Unk Thr Ile Val Met Phe Val Val Ala Phe Val Ile Unk Unk Ser Leu 70 75 Tyr Pro Lys Phe INFORMATION FOR SEQ ID NO:684: SEQUENCE CHARACTERISTICS: LENGTH: 84 amino acids TYPE: amino acid AMENDED SHEET PCT/US n 12 2 57 IPEA/US 18 DEC 1996 TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION 1...84 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:684 Arg Unk Glu Lys Ile Met Thr Asn Phe Glu Lys Unk Ile Ala Gin 5 10 Arg Leu Lys Thr Asn Ala Val Leu Thr Thr Tyr Cys Ala Ile Phe 25 Phe Ile Gly Leu Leu Val Asp Ala Ile Arg Ile Asn Ala Asn Asp 40 Gly Ile Ala Leu Phe Lys Leu Met Thr Phe Gln Ile Phe Pro Thr 55 Thr Ile Val Met Phe Val Val Ala Phe Val Ile Unk Unk Ser Leu 70 75 Pro Lys Phe Met 1 Asn Ala Leu Unk Tyr INFORMATION FOR SEQ ID NO:685: SEQUENCE CHARACTERISTICS: LENGTH: 76 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...76 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:685 Met Unk Met Ser His Ile Ile Lys Ser Ile Glu Ala Leu Asp Asp Tyr 1 5 10 Thr Ile Arg Phe Thr Leu Asn Gly Pro Glu Ala Pro Phe Leu Ala Asn 25 Leu Gly Met Asp Phe Leu Ser Ile Leu Ser Lys Asp Tyr Ala Asp Tyr 40 Leu Ala Gln Asn Asn Lys Lys Asp Glu Leu Ala Lys Unk Pro Val Gly 55 Thr Gly Pro Phe Lys Phe Phe Leu Trp Asn Lys Arg 70 INFORMATION FOR SEQ ID NO:685: SEQUENCE CHARACTERISTICS: S(A) LENGTH: 76 amino acids N W_ AMENDED SHEET -CT/tJ 09 122 IPEA/US 18 DEC 1996 572 TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...76 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:685 Met Unk Met Ser His Ile Ile Lys Ser Ile Glu Ala Leu Asp Asp Tyr 1 5 10 Thr Ile Arg Phe Thr Leu Asn Gly Pro Glu Ala Pro Phe Leu Ala Asn 25 Leu Gly Met Asp Phe Leu Ser Ile Leu Ser Lys Asp Tyr Ala Asp Tyr 40 Leu Ala Gln Asn Asn Lys Lys Asp Glu Leu Ala Lys Unk Pro Val Gly 55 Thr Gly Pro Phe Lys Phe Phe Leu Trp Asn Lys Arg 70 INFORMATION FOR SEQ ID NO:686: SEQUENCE CHARACTERISTICS: LENGTH: 196 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...196 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:686 Leu Met Arg Lys Ile Phe Ser Tyr Ile Ser Lys Val Leu Leu Phe Ile 1 5 10 Gly Val Val Tyr Ala Glu Pro Asp Ser Lys Val Glu Ala Leu Glu Gly 25 Arg Lys Gln Glu Ser Ser Leu Asp Lys Lys Ile Arg Gln Glu Leu Lys 40 Ser Lys Glu Leu Lys Asn Lys Glu Leu Lys Asn Lys Asp Leu Lys Asn 55 Lys Glu Glu Lys Lys Glu Thr Lys Ala Lys Arg Lys Pro Arg Ala Glu 70 75 Val His His Gly Asp Ala Lys Asn Pro Thr Pro Lys Ile Thr Pro Pro 90 Lys Ile Lys Gly Ser Ser Lys Gly Val Gln Asn Gln Gly Val Gln Asn 100 105 110 Asn Ala Pro Lys Pro Glu Glu Lys Asp Thr Thr Pro Gln Ala Thr Glu 115 120 125 Lys Asn Lys Glu Thr Ser Pro Ser Ser Gln Phe Asn Ser Ile Phe Gly 8~AkiRdJPfl-m PCTUS 96/09122 IPEN/US18 DEC01996 Asn 145 Gly Gin Arg 130 Pro Ile Giu Leu 573 135 140 Asn Asn Ala Thr Asn Asn Thr Leu Giu Asp Lys 150 155 Ser Leu Leu Val Asn Gly Ser Pro Ile Thr Leu 165 170 Giu Gin Glu Lys Ser Lys Val Ser (Jnk Ala Unk 180 185 Unk Unk 195 Vai Vai Gly 160 Tyr Gin Ile 175 Ala Arg Asp 190 INFORMATION FOR SEQ ID NO:686: SEQUENCE CHARACTERISTICS: LENGTH: 196 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .196 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:686 Leu Met Arg Lys Ile Phe Ser Tyr Ile Sen Lys Val Leu Leu Phe Ile 1 G ly Arg Ser Lys Val1 Lys Asn Lys Asn 145 Gly Gin Arg Val1 Lys Lys Giu His Ile Ala Asn 130 Pro Ile Giu Leu Va 1 Gin Giu Giu His Lys Pro 115 Lys Asn Sen Giu Unk 195 Tyr Glu Leu Lys G ly Gly 100 Lys Glu Asn Leu Gin 180 Unk 5 Ala Sen Lys Lys Asp Ser Pro Thr Ala Leu 165 Glu Giu Se r Asn Glu 70 Ala Sen Giu Ser Thr 150 Val1 Lys Pro Leu Lys 55 Thr Lys Lys Giu Pro 135 As n Asn Sen Asp Asp 40 Giu Lys Asn Gly Lys 120 Ser Asn G ly Lys Ser 25 Lys Leu Ala Pro Val1 105 Asp Ser Thr Ser Val1 185 10 Lys Lys Lys Lys Thr 90 Gin Thr Gin Leu Pro 170 Ser Val1 Ile Asn Ang 75 Pro Asn Thr Phe Giu 155 Ile Unk Giu Ang Lys Lys Lys Gin Pro Asn 140 Asp Thr Ala Ala Gin Asp Pro Ile Gly Gin 125 Ser Lys Leu Unk Leu Glu Leu Arg Thr Val1 110 Ala Ile Val1 Tyr Ala 190 Giu Leu Lys Ala Pro Gin Thr Phe Val1 Gin 175 Arg Gly Lys Asn Giu Pro Asn Giu Gly Gly 160 Ile Asp INFORMATION FOR SEQ ID NO:687: SEQUENCE CHARACTERISTICS: LENGTH: 142 amino acids TYPE: amino acid TOPOLOGY: linear A&MENOEW S(11Wi PCT/US 9 6 09 122 IPENAUS 18 DECi996 574 (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...142 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:687 Val Leu Trp Val Leu Tyr Phe Leu Thr Ser Leu Phe Ile Cys Ser Leu 1 5 10 Ile Val Leu Trp Ser Lys Lys Ser Met Leu Phe Val Asp Asn Ala Asn 25 Lys Ile Gln Gly Phe His His Ala Arg Thr Pro Arg Ala Gly Gly Leu 40 Gly Ile Phe Leu Ser Phe Ala Leu Ala Cys Tyr Leu Glu Pro Phe Glu 55 Met Pro Phe Lys Gly Pro Phe Val Phe Leu Gly Leu Ser Leu Val Phe 70 75 Leu Ser Gly Phe Leu Glu Asp Ile Asn Leu Ser Leu Ser Pro Lys Ile 90 Arg Leu Ile Leu Gln Ala Val Gly Val Val Cys Ile Ile Ser Ser Thr 100 105 110 Pro Leu Val Val Ser Asp Phe Ser Pro Leu Phe Ser Leu Pro Tyr Phe 115 120 125 Ile Ala Phe Leu Phe Ala Ile Phe Tyr Ala Gly Gly Tyr Gin 130 135 140 INFORMATION FOR SEQ ID NO:688: SEQUENCE CHARACTERISTICS: LENGTH: 86 amino acids.
TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...86 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:688 Met Ala Cys Lys Phe Cys Pro Lys Ile Arg Lys Thr Asp Trp Ile Phe 1 5 10 Ile Leu Ile Ala Ala Leu Gly Phe Tyr Ser Val Asn Lys Leu Gly Tyr 25 Ala Pro Lys Phe Asn Thr Pro Thr Pro Lys Ser Ser Arg Pro Leu Ser 40 Arg Pro Ile Glu Lys Pro Asn Asn Met Thr Glu Glu Glu Arg Lys Lys 55 Arg Phe Ile Glu Leu Gln Lys Ala Cys Leu Leu His Lys Asp Lys Lys 70 75 Ala Cys Glu Glu Val Phe PCT/US 96/09122 (PEA/US 18 DEC 1996 575 INFORMATION FOR SEQ ID NO:689: SEQUENCE CHARACTERISTICS: LENGTH: 121 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION 1...121 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:689 Val Asp Ser Ile Leu Ile Asp Glu Ala Arg Thr Pro Leu Ile Ile Ser 1 5 10 Gly Pro Val Asp Arg Arg Met Glu Asn Tyr Asn Lys Ala Asp Glu Val 25 Ala Lys Ser Met Gln Val Glu Val Asp Phe Thr Ile Asp Glu Lys Asn 40 Arg Ala Ile Leu Ile Thr Glu Glu Gly Ile Lys Lys Ala Glu Asn Leu 55 Phe Gly Val Asp Asn Leu Tyr Lys Ile Glu Asn Ala Ala Leu Ser His 70 75 His Leu Asp Gln Ala Leu Lys Ala Asn Tyr Leu Phe Phe Ile Asp Lys 90 Asp Tyr Ile Val Ala Asn Asn Glu Val Val Ile Val Asp Lys Phe Thr 100 105 110 Asp Arg Leu Asn Glu Gly Glu Ala Leu 115 120 INFORMATION FOR SEQ ID NO:690: SEQUENCE CHARACTERISTICS: LENGTH: 59 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...59 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:690 Met Thr Ile Thr Thr Leu Ser Phe Leu Phe Thr Thr Pro Glu Val Phe 1 5 10 Val Asn Gln Asp Phe Pro Trp Leu Ser Gly Ala Gly Arg Leu Val Val 25
PCT
576 HIPEMJS 18 DEC 1996 Lys Asp Leu Ala Leu Phe Ala Gly Gly Leu Phe Val Ala Gly Phe Asp 40 Arg Asn Ala Ile Trp Arg Val Lys Gly Phe Ala INFORMATION FOR SEQ ID NO:691: SEQUENCE CHARACTERISTICS: LENGTH: 142 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...142 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:691 Val Phe Ser Gly Asn Lys Arg Ala Ile Asn Tyr Arg Thr Ile Val Ser 1 5 10 Ala Phe Val Ile Gln Val Ala Leu Gly Ala Leu Ala Leu Tyr Val Pro 25 Leu Gly Arg Glu Ile Leu Gln Gly Leu Ala Ser Gly Ile Gln Ser Val 40 Ile Gly Tyr Gly Tyr Glu Gly Val Arg Phe Leu Phe Gly Asn Leu Ala 55 Pro Asn Ala Lys Gly Asp Gln Gly Ile Gly Gly Phe Ile Phe Ala Ile 70 75 Asn Val Leu Ala Ile Ile Ile Phe Phe Ala Ser Leu Ile Ser Leu Leu 90 Tyr Tyr Leu Lys Ile Met Pro Leu Val Ile Asn Leu Ile Gly Gly Ala 100 105 110 Leu Gln Lys Cys Leu Gly Thr Ser Lys Ala Glu Ser Met Ser Ala Ala 115 120 125 Ala Asn Unk Unk Val Ala His Thr Glu Asp Unk Leu Ser His 130 135 140 INFORMATION FOR SEQ ID NO:692: SEQUENCE CHARACTERISTICS: LENGTH: 80 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION 1...80 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:692 PCT/US 96/09 122 IPENUS 18 DEC1996 Met 1 Gly Ile Val Gly Leu Leu Asp Tyr Gly Val Gly Ile Ser Asn Ala Ile Asn Ile 5 10 Ala Ser Gly Ile Cys Ala Ile Ala Leu 25 Unk Ser Ser Leu Ser Cys Leu Leu Ala 40 Gly Val Lys Unk Pro Phe Arg Lys Asp 55 Arg Ile Phe Trp Val Trp Unk Unk Unk 70 75 Ile Asp Gly Leu Val Ile Tyr Met Val Phe Leu Gly Phe Leu Ser Phe His Leu Arg Cys Asn Tyr Gly Ser Ile INFORMATION FOR SEQ ID NO:693: SEQUENCE CHARACTERISTICS: LENGTH: 179 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...179 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:693 Met Lys Arg Ser Ser Val Phe Ser Phe Leu Val Ala 1 Val Ser Glu Pro Asp Val Thr Arg Asp 145 Gin Leu Gly Thr Lys Ala Lys Gin Asp Thr 130 Met Lys Val Cys Lys Glu Ile Tyr Lys Glu 115 Leu Ile Thr Lys Ser Ala Glu Glu Glu Ala 100 Phe Ser Lys Arg 5 His Val Pro Ser Ile Lys Gly Val Thr Glu 165 Lys Gin Lys Gly 70 Lys Glu Ser Lys Ile 150 Met Thr Gin Thr Glu Asn Ser Asn 135 Ser Asp Ala 40 Glu Ile Ser His Glu 120 Ala Phe Asn 25 Pro Pro Ile Asp Met 105 Tyr Leu Gly 10 Lys Val Ala Ala Gin 90 Gin Asn Val Glu Thr Thr Pro Ser 75 Glu Val Gin Ile Ser 155 Phe Ala Glu Val Tyr Leu Leu Leu 125 Gly Pro Leu Gly Pro Glu Phe Asp Glu 110 Gly Val Lys Leu Val Asp Val Ala Pro Glu Lys Asp Phe Glu Ile Gly Asn Val Lys Glu Lys Cys Val 160 Cys Tyr Arg Glu Asn Arg Arg Val Asp Val Lys INFORMATION FOR SEQ ID NO:693: SEQUENCE CHARACTERISTICS: LENGTH: 179 amino acids TYPE: amino acid X TOPOLOGY: linear AMENDED SHEETI PCT/US 9 6 09 122 IPENUS 18 DE C 1996 578 (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...179 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:693 Met Lys Arg Ser Ser Val Phe Ser Phe Leu Val Ala Phe Leu Leu Val 1 5 10 Val Gly Cys Ser His Lys Met Asp Asn Lys Thr Val Ala Gly Asp Val 25 Ser Thr Lys Ala Val Gln Thr Ala Pro Val Thr Thr Glu Pro Ala Pro 40 Glu Lys Glu Glu Pro Lys Gln Glu Pro Ala Pro Val Val Glu Glu Lys 55 Pro Ala Ile Glu Ser Gly Thr Ile Ile Ala Ser Ile Tyr Phe Asp Phe 70 75 Asp Lys Tyr Glu Ile Lys Glu Ser Asp Gln Glu Thr Leu Asp Glu Ile 90 Val Gln Lys Ala Lys Glu Asn His Met Gln Val Leu Leu Glu Gly Asn 100 105 110 Thr Asp Glu Phe Gly Ser Ser Glu Tyr Asn Gln Ala Leu Gly Val Lys 115 120 125 Arg Thr Leu Ser Val Lys Asn Ala Leu Val Ile Lys Gly Val Glu Lys 130 135 140 Asp Met Ile Lys Thr Ile Ser Phe Gly Glu Ser Lys Pro Lys Cys Val 145 150 155 160 Gin Lys Thr Arg Glu Cys Tyr Arg Glu Asn Arg Arg Val Asp Val Lys 165 170 175 Leu Val Lys INFORMATION FOR SEQ ID NO:694: SEQUENCE CHARACTERISTICS: LENGTH: 75 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...75 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:694 Met Leu His Lys Lys Tyr Arg Pro Asn Val Ala Ala Ile Ile Met Ser 1 5 10 Pro Asp Tyr Pro Asn Thr Cys Glu Val Phe Ile Ala Glu Arg Ile Asp 25 Ile Glu Gly Ala Trp Gln Phe Pro Gln Gly Gly Ile Asp Glu Gly Glu i
PCT/)L'
579 IPEA/US 18 DEC 1996 40 Thr Pro Leu Glu Ala Leu Tyr Arg Glu Leu Leu Glu Glu lie Gly Thr 55 Asn Glu Ile Giu Ile Leu Ala Gln Tyr Pro Arg 70 INFORMATION FOR SEQ ID NO:695: SEQUENCE CHARACTERISTICS: LENGTH: 99 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...99 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:695 Val Met Leu Met Ala Ile Phe Thr Pro Tyr Ile Leu Ile Leu Lys Met 1 5 10 Met Lys Lys Ser Met Ser Leu Phe Ala Asn Met Gly Leu Glu Gln Ile 25 Phe Cys Asn Arg Asp Ile Lys Asp Leu Asn Asp Phe Val Phe Gly Ile 40 Glu Val Gly Leu Asp Ser Asn Ala Arg Lys Asn Arg Ser Arg Lys Ala 55 Met Glu Asn His Leu Ile Gly Leu Phe Val Gln Ala Gln Leu Asn Phe 70 75 Lys Glu Gln Val Asp Ile Arg Glu Phe Giu Asp Leu Arg Gln Ala Phe 90 Gly Asn Asp INFORMATION FOR SEQ ID NO:696: SEQUENCE CHARACTERISTICS: LENGTH: 209 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...209 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:696 Met Ile Arg Leu Ala Ala Phe Phe Leu Ala Leu Ala Cys Ala Ile Thr 1 5 10 IPENUS 18 D ,396 PCT/US 96/09122 Pro Lys Ser Arg Leu Leu Leu Lys Asn Val Leu 25 Ile Val His Ile Lys Arg Glu Gin 145 Phe Leu Thr Asn Glu Ile Ala Asp Ser Ile Glu 130 Leu Asn Pro Phe Ala Gin Pro Glu Met Lys 115 Phe Lys Asp Leu Gin 195 Leu Leu 55 Ile Leu Ala Ser Phe 135 Ser Ala Asn Asn Lys 40 Glu Ser Ser Lys Asn 120 Tyr Lys Met Leu Leu 200 Lys Val Ile Ile Asp 105 Phe Ile Ile Ser Glu 185 Phe Gly Gly Gin Met Arg Ala Gly Pro 155 Ala Ala Lys Leu Ala Asp Asn Leu Ala Leu Leu 140 Pro Val Asn Arg Asn His Ile Ile Phe Lys Gly 125 Gly Ile Leu Ile Ser 205 Pro Ile Tyr Ala Ala Glu 110 Ile Asp Ile Thr Ser 190 Leu INFORMATION FOR SEQ ID NO:697: SEQUENCE CHARACTERISTICS: LENGTH: 75 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...75 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:697 Val Gly Ser Leu Lys Phe Leu Asn Ala Met Gly 1 5 10 Lys Glu Ser Ala Asn Ile Met Val Gly Phe Ala 25 Cys Ala Leu Phe Ile Leu Glu Glu Arg Leu Lys 40 Val Ile Gin Ala Leu Gin Asn Gin Gly Leu Glu 55 Gly Asp Asn Glu Ser Ser Val Lys Glu Cys Ala 70 INFORMATION FOR SEQ ID NO:698: SEQUENCE CHARACTERISTICS: LENGTH: 121 amino acids TYPE: amino acid Val Asp Leu Lys Val Lys Asn Lys Thr Leu Ala Asn Ala Lys Glu Leu Glu Ile Leu Ser PCT/i 0 9 122 IPEA/US 18 DEC 1996 581 TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...121 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:698 Met Glu Ala Leu Asn Ala Leu Asn Ala Gln Ser Asp Glu Gln Ile Leu 1 5 10 Cys Glu Gly Tyr Phe Val Leu Leu Gln Ile Leu Glu Pro Met Ile Pro 25 His Thr Ala Trp Glu Leu Ser Glu Arg Leu Phe Lys Arg Glu Asn Phe 40 Lys Pro Ile Glu Val Asp Glu Ser Ala Leu Ile Glu Asp Phe Met Thr 55 Leu Gly Leu Thr Ile Asn Gly Lys Arg Arg Ala Glu Leu Lys Val Asn 70 75 Ile Asn Ala Ser Lys Glu Glu Ile Ile Ile Leu Ala Lys Lys Glu Leu 90 Glu Lys Tyr Leu Glu Asn Ala Ser Val Lys Lys Glu Ile Tyr Val Pro 100 105 110 Asn Lys Leu Val Asn Phe Val Thr Ala 115 120 INFORMATION FOR SEQ ID NO:699: SEQUENCE CHARACTERISTICS: LENGTH: 102 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...102 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:699 Met Lys Glu Ser Ile Lys Tyr Leu Leu Glu Ser Val Gly Leu Val Leu 1 5 10 Leu Met Ser Val Asn Pro Gly Phe Gly Gly Gln Lys Phe Leu Asp Leu 25 Val Leu Glu Lys Cys Leu Lys Val Lys Glu Leu Ile Lys Arg Tyr Asn 40 Pro Ser Cys Leu Leu Glu Val Asp Gly Gly Val Asn Asp Lys Asn Ile 55 Phe Glu Leu Gln Gln Ala Gly Val Asp Val Val Val Ser Gly Ser Tyr 70 75 Ile Phe Glu Ser Lys Asp Unk Lys Leu Ala Ile Glu Gly Leu Gin Asn 90 PCT/US 9 6 09 122 582 IPEA/US 18 DEC1996 Val Arg Gln Pro Leu Ala 100 INFORMATION FOR SEQ ID NO:700: SEQUENCE CHARACTERISTICS: LENGTH: 131 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...131 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:700 Val His Asp Gly Val Leu Gly Trp Val Gly Phe Thr Leu Ile Ala Ser 1 5 10 Met Tyr His Met Thr Pro Arg Leu Phe Lys Arg Glu Ile Tyr Ser Gly 25 Arg Leu Val Asp Phe Gln Phe Trp Ile Met Thr Leu Gly Ile Val Leu 40 Tyr Phe Ser Ser Met Trp Ile Ala Gly Ile Thr Gln Gly Met Met Trp 55 Arg Asp Val Asp Gln Tyr Gly Asn Leu Thr Tyr Gln Phe Ile Asp Thr 70 75 Val Lys Ala Leu Ile Pro Tyr Tyr Asn Ile Arg Gly Val Gly Gly Leu 90 Met Tyr Phe Ile Gly Phe Ile Ile Phe Ala Tyr Asn Ile Phe Met Thr 100 105 110 Ile Thr Ala Gly Lys Lys Leu Glu Arg Glu Pro Asn Tyr Ala Thr Pro 115 120 125 Met Ala Lys 130 INFORMATION FOR SEQ ID NO:701: SEQUENCE CHARACTERISTICS: LENGTH: 441 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...441 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:701 Met Ile Thr Leu Phe Ser Phe Gly Ala Phe Ala Tyr Tyr Phe Val Ser 4 ^JT QAMENDED SH22T PCT/US 9 6 0 9 122 IPEA/US 18 DE 1996 lie Ser His Ser Phe Ala Glu Arg Ile Ser Leu Arg 145 Val Glu Val Lys Arg 225 Ala Lys Ile Ile Ile 305 Phe Glu Ser Leu Ile 385 Glu Lys Gin Gin Val Ile Asn Asn Leu Val Ile 130 Glu Ser Phe Leu Gly 210 Phe Arg Phe Asp Ile 290 Asp Ile Asp Gin Glu 370 Cys Ala Gly Lys Thr Glu Leu Ile Leu Ser 115 Leu Leu Cys Asp Phe 195 Lys Ser Ile Leu Glu 275 Glu Asn Gly Phe Ala .355 Ala Phe Asp Met Glu 435 Thr Asp Glu Trp Lys 100 Tyr Phe Arg Lys Asn 180 Leu Ile Ser Glu Met 260 Asp Ala Ala Asn Glu 340 His Met Thr Asn Lys 420 Arg Ile Tyr Lys Tyr Lys Arg Leu Ser Ser 165 Cys Arg Leu lie Gin 245 Ser Lys Asp Ile Asn 325 Lys Gly Gly lie Glu 405 Gly Thr Glu Asn Leu Val 70 Ala Asp Asn Phe Gin 150 Lys Ile Ser Ser Phe 230 Leu Asp Lys Phe Lys 310 Leu Tyr Phe Leu His 390 Glu Thr Cys Asn Glu Tyr 55 Leu Glu Glu Tyr Leu 135 Val Gin Gin Ile Ser 215 Asp Ala Leu Ser Glu 295 Tyr Val Leu Gly Asn 375 Asp Leu Glu Ser Tyr Ile 40 Lys Ala Val His Phe 120 Phe Lys Lys Lys Met 200 Met His Ser Ile Pro 280 Leu Ser Val Gin Leu 360 Leu Cys Pro Lys Asn 440 Gin 25 Leu Ile Lys Phe Phe 105 Leu Val Arg Asp Ile 185 His Leu Leu Lys Asp 265 Ile Phe Asp Ser Pro 345 Gly Ser Val Pro Ala 425 Asp Asn Asn Gly Arg Lys 90 Val Ala Leu Phe Glu 170 Asn Glu Lys Asn Asn 250 Lys His Ala Asp Asn 330 Tyr Met Tyr Phe Pro 410 Asn Glu Asn Phe Arg 75 Phe Leu Ile Gin Ala 155 Ile Ala Leu Glu Met 235 Tyr Ile Val Ile Lys 315 Lys Phe Tyr His Asn 395 Glu Cys Met Tyr Arg His Ser Tyr Thr Ser 140 Gin Gly Met Arg Glu 220 Leu Gly Glu Ser Ala 300 Gin Ser Lys Ile Tyr 380 Ser Asn Gly Arg Ser Glu Gin Asp Lys Val 125 Leu Gly Asp Asn Thr 205 Leu Ile Ser Lys Ser 285 Leu Val Lys Ser Ile 365 Ser Phe Leu Val His Asp Thr Leu Met Asp 110 Gly Leu Asp Leu Glu 190 Pro Ser Glu Asn Met 270 Ser Lys Phe Pro Ser 350 Lys Asn Tyr Arg Lys 430 Tyr Tyr Thr His Val Leu Leu Pro Lys Ala 175 Ser Ile Cys Gin Lys 255 Leu Asn Asn Leu Leu 335 Asn Asn Gly Asp Glu 415 Glu Gin Arg Ile His Phe His Leu Leu Ser 160 Asn Arg Thr Lys Phe 240 Glu Leu Tyr Met Asp 320 Lys Pro Ala Arg Leu 400 Val Lys INFORMATION FOR SEQ ID NO:702: SEQUENCE CHARACTERISTICS: LENGTH: 127 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein 'AMENDED SHLT PCT/US 9 0 9 122 IPEA/JS 18 DEC1996 584 (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION 1...127 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:702 Val Leu Leu Leu Ser Arg Met Gly Ile Ala Phe Ala His Ser Ile Phe 1 5 10 Trp Ser Ile Thr Ala Ser Leu Val Ile Arg Val Ala Pro Arg Asn Lys 25 Lys Gln Gln Ala Leu Gly Leu Leu Ala Leu Gly Ser Ser Leu Ala Met 40 Ile Leu Gly Leu Pro Leu Gly Arg Ile Ile Gly Gln Ile Leu Asp Trp 55 Arg Ser Thr Phe Gly Val Ile Gly Gly Val Ala Thr Leu Ile Met Leu 70 75 Leu Met Trp Lys Leu Leu Pro His Leu Pro Ser Arg Asn Ala Gly Thr 90 Leu Ala Ser Val Pro Ile Leu Met Lys Arg Pro Leu Leu Val Gly Ile 100 105 110 Tyr Leu His Val Asn His Gly Tyr Phe Trp Ala Phe His His Leu 115 120 125 INFORMATION FOR SEQ ID NO:703: SEQUENCE CHARACTERISTICS: LENGTH: 286 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...286 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:703 Met Gly Thr Leu Ile Giu Lys Trp Phe Gly Phe Ser Gln Ile Arg Glu 1 5 10 Glu Leu Glu Ala Arg Ile Ser Glu Leu Glu Asp Glu Asn Thr Glu Leu 25 Leu Arg Glu Arg Glu Tyr Leu Ala Ala Glu Thr Ser Glu Leu Lys Asp 40 Ala Asn Asp Gln Leu Arg Gin Lys Asn Asp Lys Leu Phe Ile Thr Lys 55 Asp Lys Leu Thr Lys Glu Asn Thr Glu Leu Phe Ala Glu Asn Glu Ser 70 75 Leu Ser Val Lys Ile Ser Gly Leu Glu His Ser Asn Asp Gln Leu Trp 90 Gin Asn Asn Asn Lys Leu Thr Lys Glu Lys Ala Glu Leu Lys Thr Glu 100 105 110 Lys Asp Ile Leu Ala Lys Glu Asn Thr Arg Leu Leu Ala Ala Arg Asp AkIFNI'73 t POUS C,6 0 912 IPEANS 18 D EC 1996 Arg Lys 145 Glu Thr Leu Lys Gin 225 Asn Unk Tyr Leu Thr Glu Giu Lys Arg Giu Leu Thr Thr Glu 130 Arg Asn Ala Gin Giu 210 Lys Ser Ser Gly Giu Lys Leu Asp 195 Asn Ser Asn Giu Ser 275 His As n Ser Giu Lys As n Ala Arg 265 Thr Lys Asp 170 Leu Lys Leu Gin Lys 250 Thr Tyr Ile 155 Lys Giu Arg Lys Leu 235 Giu Leu Thr 125 Lys Giu Asn Giu Thr 205 Leu Gin Ile Giu Gly 285 Glu Arg Leu INFORMATION FOR SEQ ID NO:703: SEQUENCE CHARACTERISTICS: LENGTH: 286 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .286 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:703 Met Gly Thr Leu Ile Giu Lys Trp Phe Gly Phe Sen 1 Giu Leu Ala Asp Leu Gin Lys Ang Lys 145 Glu Leu Arg Asn Lys Ser Asn Asp Leu 130 Arg Asn Giu Giu Asp Leu Val1 Asn Ile 115 Thr Giu Lys Ala Arg Gin Thr Lys As n 100 Leu Giu Asn Ala 5 Arg Glu Leu Lys Ile Lys Ala Glu Thr Leu 165 Ile Tyr Arg Glu 70 Sen Leu Lys Lys Glu 150 Thr Ser Leu Gin 55 Asn Gly Thr Giu Arg 135 Leu Thr Giu Ala 40 Lys Thr Leu Lys Asn 120 Giu Thr Glu Leu 25 Ala Asn Glu Glu Giu 105 Thr Leu His Asn.
Giu Giu Asp Leu His 90 Lys Arg Thr Lys Asp 170 Asp Thr Lys Phe 75 Sen Ala Leu Thr Ile i55 Lys Giu Ser Leu Ala Asn Giu Leu Giu 140 Thr Leu Gin Asn Glu Phe Giu Asp Leu Ala 125 Lys Giu Asn Ile Thr Leu Ile Asn Gin Lys 110 Ala Giu Leu His Arg Giu Lys Thr Giu Leu Thr Arg Arg Thr Gin 175 Glu Leu Asp Lys Sen Trp Giu Asp Leu Lys 160 Val1 PCT/US 96/09122 IPEA/US 18 DEC196 586 Thr Ala Leu -Thr Asn Glu Arg Asp Ser Leu Glu Gin Glu Arg Ala Arg 180 185 190 Leu Gln Asp Ala His Gly Phe Leu Glu Lys Arg Cys Thr Asn Leu Glu 195 200 205 Lys Glu Asn Gln Arg Leu Thr Asp Lys Leu Lys Gln Leu Glu Ser Ala 210 215 220 Gin Lys Ser Leu Glu Asn Thr Asn Asn Gln Leu Arg Gln Ala Leu Glu 225 230 235 240 Asn Ser Asn Val Gln Leu Ala Gln Ala Lys Glu Unk Ile Ala Ile Glu 245 250 255 Unk Ser Glu Leu Unk Arg Arg Asn Arg Thr Leu Glu Glu Leu Arg Gly 260 265 270 Tyr Gly Ser Gln Lys Unk Ile Trp'Thr Tyr Thr Unk Gly Val 275 280 285 INFORMATION FOR SEQ ID NO:704: SEQUENCE CHARACTERISTICS: LENGTH: 110 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...110 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:704 Val Leu Arg Lys Leu Leu Gly Lys Asn Cys Ile Glu Thr His Lys Gly 1 5 10 Val Gly Tyr Arg Leu Thr His Tyr Glu Lys Lys Ser Leu Lys Leu Phe 25 Leu Gly Thr Tyr Leu Gly Ser Ser Phe Val Leu Met Leu Val Ile Ser 40 Val Leu Ala Phe Asn Tyr Glu Lys Asn Glu Lys Ile Lys Unk Ile Arg 55 Met Asp Met Asp Lys Met Ala Ser Lys Ile Ala Ser Glu Ile Ile Gin 70 75 Leu His Met Gln Thr His Ala Asp Tyr His Asn Ala Leu Asn Ala Leu 90 Ile Ser Arg Tyr Lys Asp Val Ser Ile Unk Leu Unk Asp Thr 100 105 110 INFORMATION FOR SEQ ID NO:704: SEQUENCE CHARACTERISTICS: LENGTH: 110 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori .i.lt PCT/US 96/09122 so, IPENU 18 DEC199G (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...110 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:704 Val Leu Arg Lys Leu Leu Gly Lys Asn Cys Ile Glu Thr His Lys Gly 1 5 10 Val Gly Tyr Arg Leu Thr His Tyr Glu Lys Lys Ser Leu Lys Leu Phe 25 Leu Gly Thr Tyr Leu Gly Ser Ser Phe Val Leu Met Leu Val Ile Ser 40 Val Leu Ala Phe Asn Tyr Glu Lys Asn Glu Lys Ile Lys Unk Ile Arg 55 Met Asp Met Asp Lys Met Ala Ser Lys Ile Ala Ser Glu Ile Ile Gin 70 75 Leu His Met Gln Thr His Ala Asp Tyr His Asn Ala Leu Asn Ala Leu 90 Ile Ser Arg Tyr Lys Asp Val Ser Ile Unk Leu Unk Asp Thr 100 105 110 INFORMATION FOR SEQ ID NO:705: SEQUENCE CHARACTERISTICS: LENGTH: 115 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_ feature LOCATION 1...115 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:705 Met Arg Ile Ile Ile Arg Leu Leu Ser Phe Lys Met Asn Ala Phe Leu 1 5 10 Lys Leu Ala Leu Ala Ser Leu Met Gly Gly Leu Trp Tyr Ala Phe Asn 25 Gly Glu Gly Ser Glu Ile Val Ala Ile Gly Ile Phe Val Leu Ile Leu 40 Phe Val Phe Phe Ile Arg Pro Val Ser Phe Gln Asp Pro Glu Lys Arg 55 Glu Glu Tyr Ile Glu Arg Leu Lys Lys Asn His Glu Arg Lys Met Ile 70 75 Leu Gln Asp Lys Gln Lys Glu Glu Gln Met Arg Leu Tyr Gln Ala Lys 90 Lys Glu Arg Giu Ser Arg Gln Lys Gln Asp Leu Lys Glu Gin Met Lys 100 105 110 Lys Tyr Ser 115 INFORMATION FOR SEQ ID NO:706: SEQUENCE CHARACTERISTICS: LENGTH: 86 amino acids PCT/US 96/09122 IPEA/US 18 DEC1996 (BJ TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...86 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:706 Val Arg Ser Cys Lys Gln Ile Phe Asp Lys Gly Leu Lys Pro Tyr Tyr 1 5 10 Lys His Ser Val Cys Leu Lys Pro Phe Phe Arg Phe Cys Phe Leu Lys 25 Ile His Ala Tyr Gln Gln Arg Tyr Arg Ala Phe Ala Leu Thr Leu Phe 40 Ser Cys Lys Phe Phe Asn Ala Cys Lys Ile Phe Ile Pro Ile Ile Asp 55 Phe Lys Ile Val Phe Ile Pro Ile Leu Lys His Gln Ala Lys Leu Lys 70 75 Arg Val Ser Asn Ala Tyr INFORMATION FOR SEQ ID NO:707: SEQUENCE CHARACTERISTICS: LENGTH: 44 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix).FEATURE: NAME/KEY: misc_feature LOCATION 1...44 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:707 Met Cys Gly Met Gly Phe Ile Gly Phe Lys Thr Lys Leu Thr Gln Thr 1 5 10 Lys Ala Phe Ile Ile Leu Ile Pro Ile Phe Gin Asp Arg Ala Val Lys 25 Ala Ala Thr Arg Ser Ala Pro Ile Gln Leu Ile Cys INFORMATION FOR SEQ ID NO:708: SEQUENCE CHARACTERISTICS: LENGTH: 560 amino acids TYPE: amino acid TOPOLOGY: linear V/T ~AMENDED SKEa POT/US 96/09122 589 (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...560 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:708 Met Gly Asn Phe Asn Ser Tyr Gly Asp Leu Val Phe Asn Leu Ser His 1 5 10 Ser Val Ser His Ala Ile Ile Asn Thr Gin Gly Thr Ala Thr Ile Met 25 Ala Asn Asn Asn Pro Leu Ile Gln Phe Asn Ala Ser Ser Lys Glu Val 40 Gly Thr Tyr Thr Leu Ile Asp Ser Ala Lys Ala Ile Tyr Tyr Gly Tyr 55 Asn Asn Gln Ile Thr Gly Gly Ser Ser Leu Asp Asn Tyr Leu Lys Leu 70 75 Tyr Ala Leu Ile Asp Ile Asn Gly Lys His Met Val Met Thr Asp Asn 90 Gly Leu Thr Tyr Asn Gly Gln Ala Val Ser Val Lys Asp Gly Gly Leu 100 105 110 Val Val Gly Phe Lys Asp Ser Gln Asn Gln Tyr Ile Tyr Thr Ser Ile 115 120 125 Leu Tyr Asn Lys Val Lys Ile Ala Val Ser Asn Asp Pro Ile Asn Asn 130 135 140 Pro Gln Ala Pro Thr Leu Lys Gln Tyr Ile Ala Gln Ile Gln Gly Val .145 150 155 160 Gin Ser Val Asp Ser Ile Unk Gln Ala Gly Gly Asn Gln Ala Ile Asn 165 170 175 Trp Leu Asn Lys Ile Phe Glu Thr Lys Gly Ser Pro Leu Phe Ala Pro 180 185 190 Tyr Tyr Leu Glu Ser His Ser Thr Lys Asp Leu Thr Thr Ile Ala Gly 195 200 205 Asp Ile Ala Asn Thr Leu Glu Val Ile Ala Asn Pro Asn Phe Lys Asn 210 215 220 Asp Ala Thr Asn Ile Leu Gin Ile Asn Thr Tyr Thr Gln Gln Met Ser 225 230 235 240 Arg Leu Ala Lys Leu Ser Asp Thr Ser Thr Phe Ala Arg Ser Asp Phe 245 250 255 Leu Giu Arg Leu Glu Ala Leu Lys Asn Lys Arg Phe Ala Asp Ala Ile 260 265 270 Pro Asn Ala Met Asp Val Ile Leu Lys Tyr Ser Gin Arg Asn Arg Val 275 280 285 Lys Asn Asn Val Trp Ala Thr Gly Val Gly Gly Ala Ser Phe Ile Ser 290 295 300 Gly Gly Thr Unk Thr Leu Tyr Gly Ile Asn Unk Gly Tyr Asp Arg Phe 305 310 315 320 Ile Lys Gly Val Ile Val Gly Gly Tyr Ala Ala Tyr Gly Tyr Ser Gly 325 330 335 Phe His Ala Asn Ile Thr Gln Ser Gly Ser Ser Asn Val Asn Val Gly 340 345 350 Val Tyr Ser Arg Ala Phe Ile Lys Arg Ser GIu Leu Thr Met Ser Leu 355 360 365 Asn Glu Thr Trp Gly Tyr Asn Lys Thr Phe Ile Asn Ser Tyr Asp Pro 370 375 380 Leu Leu Ser Ile Ile Asn Gln Ser Tyr Arg Tyr Asp Thr Trp Thr Thr 385 390 395 400 Asp Ala Lys Ile Asn Tyr Gly Tyr Asp Phe Met Phe Lys Asp Lys Ser 405 410 415 AMENDED SHEETi PW/US 9 6 /U9 12 1PENUS L 1iuJj96 Val Ser Ala Leu 465 Ala Val Tyr Lys Tyr 545 Ile Gly Asn 450 Glu Asp Arg Asn Thr 530 Lys Phe Leu 435 Ala Ser Val Phe Thr 515 Phe Asp Lys 420 Arg Asp Arg Gly Ile 500 Phe Tyr Ile Pro Gin Gly Ile Pro Asn His Tyr 470 Arg Asp 485 Gly Asn Ala Ser Val Asn Asn Ile 550 Val Met Lys 455 Phe Leu Asn Ile Ala 535 Thr Gly Leu 425 Asp Asp 440 Lys Ser Asn Lys Phe Ile Thr Leu 505 Ile Thr 520 Gly Ile Gly Asn Ser Pro Val Asn Asn 490 Ser Gly Gly Ile 590 Tyr T lie
T
Leu TI 4( Ser T) 475 Ser ME Tyr Az Gly G] Ala Ar 54 Gly Me 555 r r r r t 9 u 9 0 t Tyr Asn 445 Ile Tyr Gly Asp Ile 525 Phe Unk Ile 430 Gin Asn Phe Asp Gly 510 Arg Gly Unk Gly Leu Phe Arg Phe Ala Val Ile 480 Lys Met 495 Gly Arg Leu Phe Leu Asp Unk Phe 560 INFORMATION FOR SEQ ID NO:709: SEQUENCE CHARACTERISTICS: LENGTH: 124 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...124 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:709 Leu Met Thr Lys Ser Leu Lys Leu Ile Gln Lys 1 Tyr Val Val Asp Gly Phe Asp Leu Ser Leu Met Ala Leu 100 Ala Lys His Phe Glu His Lys Gly Leu 25 Gly Ile Val Glu Ile 105 Ile Val Asp Thr Leu Ser Leu Val Lys Thr Phe Lys Gly Ala Ile 110 INFORMATION FOR SEQ ID NO:709: SEQUENCE CHARACTERISTICS: LENGTH: 124 amino acids TYPE: amino acid TOPOLOGY: linear IV I POT/US 96/09122 IPENUS 8DECi396 591 (ii) MQLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...124 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:709 Leu Met Thr Lys Ser Leu Lys Leu Ile Gin Lys Gly Val Lys Asn Leu 1 5 10 Tyr Glu Thr Leu Lys Asn Arg Ala Leu Glu His Gin Asp Thr Leu Met 25 Val Gly Arg Ser His Gly Val Phe Gly Glu Pro Ile Thr Phe Gly Leu 40 Val Leu Ala Leu Phe Ala Asp GIu Ile Lys Arg His Leu Lys Ala Leu 55 Asp Leu Thr Met Glu Phe Ile Unk Val Gly Ala Ile Ser Gly Ala Met 70 75 Gly Asn Phe Ala His Ala Pro Leu Glu Leu Glu Glu Leu Ala Cys Gly 90 Phe Leu Gly Leu Lys Thr Ala Asn Ile Ser Asn Gin Val Ile Gln Arg 100 105 110 Asp Arg Tyr Ala Gly Leu His Ala Ile Trp Leu Phe 115 120 INFORMATION FOR SEQ ID NO:710: SEQUENCE CHARACTERISTICS: LENGTH: 95 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...95 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:710 Leu Ser Asp Ala Ser Lys Arg Ser Leu Asn Pro Thr Leu Met Met Asn 1 5 10 Asn Asn Asn Thr Leu Pro Lys Pro Leu Glu Glu Ser Leu Asp Leu Lys 25 Glu Phe Ile Ala Leu Phe Lys Thr Phe Phe Ala Lys Glu Arg Gly Ser 40 Ile Ala Leu Glu Asn Asp Leu Lys Gln Ala Phe Thr Tyr Leu Asn Glu 55 Val Asp Ala Ile Gly Leu Pro Ala Pro Unk Lys Arg Glu Arg Lys Arg 70 75 Ser Tyr Cys Cys Gin Thr His Gin Ile Arg Asp Ala Pro Phe Arg 90 AMENDED SHEE PTIUS.96/ 09 122 ive uo J uEC1996 592 INFORMATION FOR SEQ ID NO:710: SEQUENCE CHARACTERISTICS: LENGTH: 95 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...95 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:710 Leu Ser Asp Ala Ser Lys Arg Ser Leu Asn Pro Thr Leu Met Met Asn 1 5 10 Asn Asn Asn Thr Leu Pro Lys Pro Leu Glu Glu Ser Leu Asp Leu Lys 25 Glu Phe Ile Ala Leu Phe Lys Thr Phe Phe Ala Lys Glu Arg Gly Ser 40 Ile Ala Leu Glu Asn Asp Leu Lys Gln Ala Phe Thr Tyr Leu Asn Glu 55 Val Asp Ala Ile Gly Leu Pro Ala Pro Unk Lys Arg Glu Arg Lys Arg 70 75 Ser Tyr Cys Cys Gln Thr His Gln Ile Arg Asp Ala Pro Phe Arg 90 INFORMATION FOR SEQ ID NO:711: SEQUENCE CHARACTERISTICS: LENGTH: 80 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...80 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:711 Leu Pro Ile Ile Leu Unk Val Ile Val Met Met Phe Phe Ser Lys Ile 1 5 10 Val Gly Asp Phe Ile Glu Lys His Tyr Arg Val Lys Thr Leu Ala Phe 25 Val Phe Leu Leu Val Val Gly Val Phe Leu Phe Leu Glu Gly Leu His 40 Leu His Ile Asn Lys Asn Tyr Leu Tyr Ala Gly Ile Gly Phe Ala Leu 55 Leu Ile Glu Cys Leu Unk Ile Phe Ile Glu Lys Lys Met Lys Lys Ser 65 70 75 AMENDED SHEET PGT/US 96/09122 E593 S 18 DEC 1996 INFORMATION FOR SEQ ID NO:711: SEQUENCE CHARACTERISTICS: LENGTH: 80 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...80 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:711 Leu Pro Ile Ile Leu Unk Val Ile Val Met Met Phe Phe Ser Lys Ile 1 5 10 Val Gly Asp Phe Ile Glu Lys His Tyr Arg Val Lys Thr Leu Ala Phe 25 Val Phe Leu Leu Val Val Gly Val Phe Leu Phe Leu Glu Gly Leu His 40 Leu His Ile Asn Lys Asn Tyr Leu Tyr Ala Gly Ile Gly Phe Ala Leu 55 Leu Ile Glu Cys Leu Unk Ile Phe Ile Glu Lys Lys Met Lys Lys Ser 70 75 INFORMATION FOR SEQ ID NO:712: SEQUENCE CHARACTERISTICS: LENGTH: 141 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...141 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:712 Met Glu Ser Asn Gin Ser Leu Pro Met Ala Leu Ile Ser Cys Ser Pro 1 5 10 Asn Ala Lys Gly Ala Asp Ile Lys Gly Tyr Asn Gly Leu Val Gly Glu 25 Leu Ile Glu Arg Asn Phe Gln Arg Tyr Gly Val Pro Leu Leu Leu Ser 40 Thr Leu Thr Asn Gly Leu Leu Ile Gly Ile Thr Ser Ala Leu Asn Asn 55 Arg Gly Asn Lys Glu Glu Val Thr Asn Phe Phe Gly Asp Tyr Leu Leu 70 75 Leu Gin Leu Met Arg Gln Ser Gly Met Gly Ile Asn Gin Val Val Asn 9 0 ~~Q3O 96122 Gin Glu Ile Ile Gly Pro 130 594 Leu Arg Asp Lys Ser Lys Ile Ala Pro Ile Val Val 100 105 110 Ser Arg Val Phe Ile Ser Pro Asn Thr Asp Ile Phe 115 120 125 Arg Glu Asn Glu Val Ile Ala Glu Phe Leu Lys 135 140 Ile Arg Phe Pro INFORMATION FOR SEQ ID NO:713: SEQUENCE CHARACTERISTICS: LENGTH: 51 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...51 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:713 Val Asn Phe Tyr Leu Ser Pro Lys Asp Tyr His His Tyr His Ala Pro 1 5 10 Cys Asp Leu Glu Ile Leu Glu Ala Arg Tyr Phe Ala Gly Lys Leu Leu 25 Pro Val Asn Lys Pro Ser Leu His Lys Lys Gin Asn Leu Phe Val Gly 40 Asn Glu Arg INFORMATION FOR SEQ ID NO:714: SEQUENCE CHARACTERISTICS: LENGTH: 233 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...233 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:714 Met Asp Ile Leu Lys Ala Giu His Leu Asn Lys Gin 1 5 10 Lys Ile Val Ser Asp Val Ser Leu Glu Val Lys Ser 25 Gly Leu Leu Gly Pro Asn Gly Ala Gly Lys Thr Thr 40 Ile Cys Gly Leu Leu Glu Pro Ser Gly Gly Ser Val Ile Lys Lys Thr Gly Giu Val Val Thr Phe Tyr Met Tyr Leu Asn Asp 'AMENDED SHEET PGCJI/K
I
IPEA/US i ~i9 Val Asp Gly Tyr Glu Asn Ser Giu Ile Arg 130 Val Glu 145 Asp Glu Arg Ile Asp His Ile Lys 210 Lys Thr 225 Leu Leu Leu Glu 115 Glu Ile Pro Ile As n 195 Ser Leu Ala Pro Ala 100 Lys Arg Ala Phe Giu 180 Val1 Gly Trp Lys Gin Leu Met Lys Arg Ala 165 Ser Arg Thr Cys Tyr 70 Giu Ala Glu Gly Ala 150 Gly Leu Giu Leu Val1 230 Pro Ser Gly Ser Met 135 Leu Val1 Ile Thr Leu 215 Ser Leu Ser Giu Leu 120 Ser Met Asp Gly Leu 200 Ala Ile His Ile Ser 105 Leu Leu Lys Pro Leu 185 Ser Ala Ile Lys Phe 90 Thr Asp Ser Asn Ile 170 Asn Val1 Gly Arg 75 Lys Phe Ala Giy Pro 155 Ala Ile Cys Thr Ser Asn Giu Leu Lys Asn Phe Asn 125 Gly Giu 140 Lys Phe Val Ile Gly Val His Arg 205 Leu Met 220 Leu Ser Ser 110 Ile Arg Val1 Asp Leu 190 Ala Lys Gly Ile Val Giu Lys Giu Gin Ala Arg Arg Leu Leu 160 Ile Gin 175 Ile Thr Tyr Val Phe Met INFORMATION FOR SEQ ID NO:715: SEQUENCE CHARACTERISTICS: LENGTH: 265 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacterpylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1 .265 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:715 Met Ile Lys Ala Arg Phe Lys Lys Arg Leu Leu Gly 1 Phe Leu Ala Val1 Lys Val His Ile Ala 145S Asp Leu Gly Trp Ile Tyr G lu Pro 130 Leu Asp Gly Val1 Gin 70 Phe Ala Leu Gly Lys 150 Leu Ala Ser 55 Lys Gin Phe Met Gly 135 Asn Giu Gly Ser Lys Asp Ala Arg 120 Gin Leu 10 Lys Ser Tyr Phe Ala Pro Giu Gin Leu Giu Thr Ile Leu Leu Lys As n Arg Leu 155 Ala Ile Giu Lys Phe Asp Leu Vali 140 Asp Ser Glu Leu Ala Pro Pro Lys Ser 125 Ala Glu Arg Val1 Arg As n Gin His As n 110 Gin Leu Pro Gly Val Ile His Gin Leu Lys Gin Ala Leu 0A/1 ~AMENDED SHEE17 PCTIUS 0 /,12g IPENUS L~x :96 Ala Phe Asn Val Val1 225 Pro Leu Leu Ile Giu Ile 210 Lys Gin Asp Asn Arg 180 Thr Pro Leu Ilie Ile 260 Lys Leu Ala G lu 215 Asp Pro Lys As n Ser Arg 200 Asn Glu Lys Lys Giu Val1 185 Thr Arg Asn Asp Phe 265 596 Gin Gin Leu Val Leu Phe Phe Ser 220 Cys His 235 Leu Asn Leu 175 Asp Asn Leu Val Phe 255 INFORMATION FOR SEQ ID NO:715: SEQUENCE CHARACTERISTICS: LENGTH: 265 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Heiicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1 .265 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:715 Met Ilie Lys Ala Arg Phe Lys Lys Arg Leu Leu Gly Sen Arg 1 Phe Asp Leu Leu Ala Gly Val Trp Lys Ile Val Tyr His Giu Ile Pro 130 Ala Leu 145 Ala Leu Phe Ile Asn Giu Vai Ilie 210 ,\V1 Lys Leu Asn Gly Giu Leu Giu Leu Asp Giy Phe Gin Asn 100 Vai Leu 115 Lys Leu Ile Ala Asp Asn Lys Ang 180 Ile Thn 195 Asp Pro Pro Leu
S
Ile 5cr Ala Thn Val1 Ile Arg Ser Ala Ala 165 Glu Lys As n Phe Asp Gly Val1 Gin 70 Phe Ala Leu Giy Lys 150 Leu Asn Leu Gin Glu Leu Ala Sen 55 Lys Gin Phe Met Gly 135 As n Lys Leu Ala Giu 215 Asp Giu Gly 40 Ser Lys Asp Ala Arg 120 Gin Leu Asn Ser Arg 200 Asn Giu Ile 25 Lys Giy Ile Tyr His 105 Leu Ala Leu G iu Val1 185 Thr Arg Asn 10 Lys 5cr Phe Ala 90 Pro Giu Gin Leu Val1 170 Leu Phe Leu Tyr Giu Thr Ile Leu 75 Leu Lys Asn Arg Leu Gin Leu Leu Phe Cys Ala Ile Giu Lys Phe Asp Leu Vai 140 Asp Gin Val1 Phe Ser 220 His Giu Vai Leu Arg Ala Asn Pro Gin Pro His Lys Asn 110 Sen Gin 125 Ala Leu Glu Pro Giy Leu Sen His 190 Leu Asn 205 Asn Arg Tyr Giu 31y is Val Ile His Gin Leu Lys Gin Ala Leu Leu 175 Asp As n Leu Val Ala Ala Leu Arg Asn Ile Lys Ang Asn 160 Asp Pro G ly Leu Ile ~K ~~<I'AMENDED $HEE POT/US 9 n 9122 IPE US 18 DEC 1996 597 225 230 235 240 Pro Gln Thr Ile Ser Leu Pro Lys Asp Cys Leu Asn Pro Thr Phe Lys 245 250 255 Leu Asp Phe Ile Gln Asn Lys Lys Phe 260 265 INFORMATION FOR SEQ ID NO:716: SEQUENCE CHARACTERISTICS: LENGTH: 158 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...158 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:716 Met Lys Glu Ile Val Thr Ile Glu Asn Val Ser Phe Asn Tyr His Asn 1 5 10 Arg Ala Ile Phe Lys Asp Phe Asn Leu Ser Ile Gln Glu Gly Asp Phe 25 Leu Cys Val Leu Gly Glu Ser Gly Ser Gly Lys Ser Thr Leu Leu Gly 40 Leu Ile Leu Gly Leu Leu Lys Pro Ser Leu Gly Ser Val Lys Ile Phe 55 Asn GIu Thr Leu Ser Asn Asn Ala Phe Leu Arg Gln Lys Ile Gly Tyr 70 75 Ile Ala Gln Gly Asn Ser Leu Phe Pro His Leu Asn Ala Leu Gln Asn 90 Met Thr Phe Cys Leu Asn Leu Gln Gly Ile Asn Lys Gln Ala Ala Gin 100 105 110 Lys Glu Ala Lys Ala Leu Ala Leu Lys Met Gly Leu Asp Glu Ser Leu 115 120 125 Met Asp Lys Phe Pro Asn Glu Leu Ser Gly Gly Gin Ala Lys Glu Trp 130 135 140 Ala Leu Leu Gly Gly Leu Ser Thr Gly Gln Asn Ser Phe Tyr 145 150 155 INFORMATION FOR SEQ ID NO:717: SEQUENCE CHARACTERISTICS: LENGTH: 191 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature AMENDED SHEET PCT/US 96/09122 IPENUS 18 DE C 396 598 LOCATION 1...191 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:717 Met Ile Phe Pro Glu Arg Phe Gin Asn Ala Phe Leu Gly Leu Ser Glu 1 5 10 Leu Phe Tyr Tyr Ala Ser Ser Leu Ser Phe Tyr Thr Ile Leu Ser Leu 25 Ser Pro Ile Leu Leu Phe Val Phe Ser Leu Phe Val Ser His Tyr Leu 40 Gin Ala His Ser Gly Glu Met Glu Ala Leu Ile Phe Pro Asn Ala Pro 55 Lys Leu Ile Gly Ala Ile Lys Asp Phe Leu Glu Asn Phe Lys Lys Thr 70 75 Asp Met Thr Leu Gly Thr Leu Glu Glu Val Ser Ile Val Val Ala Leu 90 Val Leu Phe Cys Glu Asn Tyr Arg Ser Ile Ala Ser Lys Ile Phe Asp 100 105 110 Ala Lys Pro Arg Asp Tyr Ala His Phe Lys Gly Lys Glu Ile Phe Leu 115 120 125 Phe Trp Gly Phe Gly Thr Thr Leu Val Phe Leu Phe Ala Leu Pro Leu 130 135 140 Val Val Phe Phe Asp Ile Lys Ile Gln Val Phe Phe Glu Asp Lys Asp 145 150 155 160 Ser Ser Leu Leu His Val Leu Arg Trp Ile Gly Thr Tyr Ala Phe Phe 165 170 175 Leu Ile Leu Phe Thr Ile Pro Thr Asn Lys Val Phe Lys Leu Lys 180 185 190 INFORMATION FOR SEQ ID NO:718: SEQUENCE CHARACTERISTICS: LENGTH: 243 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix).FEATURE: NAME/KEY: misc_feature LOCATION 1...243 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:718 Met Val Leu Met Ile Phe Thr Ser Ile Leu Lys Ile Ala Leu Lys Val 1 5 10 Leu Ser Glu Arg Lys Lys Asn Arg Tyr Gly Phe Pro Arg Ile Phe Asp 25 Val Ala Asp Ile Glu Gin Glu Glu Arg Glu Val Ile Glu Trp Arg Glu 40 Lys Lys Lys Ala Ser Lys Gin Ser Tyr Lys Gln Asn Leu Gln Ile Asn 55 Lys Ile Ala Asn Asp Leu Lys Arg Asp Lys Ile Val Asp Lys Arg Thr 70 75 Ile Leu Ser Val Ile Asp Ala Asp Ile Glu Arg Gly Phe Ile Pro Pro 90 Lys Asp Leu Leu Lys Gin Leu Glu Lys Ile Ser Ala Ser Leu Ser Lys RAA 100 105 110 Asp Ile Val Ile Thr Ile Lys Gln Val Glu Lys Leu Glu Leu Asn Tyr T 'AMENDED SHEET, PCTUS 96/09 122 1PENUS 18 UE i 96 Ala Phe 145 Thr Leu Leu Lys Thr 225 Lys Asp Ile Leu Ile 180 Val1 Leu Ile Asn Val1 Val1 165 Gly Arg Lys Phe Ile Gly 150 Ile Lys Leu Asn Asn 230 Gin 135 Asp Asp Leu Ser Ala 215 Gly 125 Asp Ser Ser Arg Ile 205 Giu Asn Thr Leu Glu Glu 190 Giu Glu Asp Asp Val1 160 Phe Ala Pro Leu Lys 240 INFORMATION FOR SEQ ID NO:719: SEQUENCE CHARACTERISTICS: LENGTH: 236 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .236 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:719 Val Ser Glu Val Ala Ser Val Gly Gly Phe Val Lys Asp Tyr Glu Val 1 Thr Val Ile Gin Ile Pro Gly Ala Lys 145 Asp Ile Leu Ala Leu so- Ser Pro Arg Ile Ile 130 Ile Asn Ile Gin Asn GiU Leu Leu Arg Val1 115 Lys Thr Leu Ala
S
Asp Ile Giy Asp Ile Ala Val1 Lys Val1 His 165 Phe Sen Lys Phe Leu 70 Lys Ala Arg Ile Tyr 150 Thr Leu Leu Asn Glu 55 Giu Asp Asn Tyr Ala 135 Asp Leu Leu Ile Ser 40 Lys Giu Ile Leu His 120 Thr Ang I le His Cys 200 Ang Asn Ile Ile Ala Asn 105 Ala Leu Ser Glu Phe 185 Ile 10 Tyr Asn Ile Val Sen 90 Gly Asp Gin Giu Glu 170 Arg Sen Asn Asp Arg Val1 75 Val1 Asp Thr Ala Leu 155 Ser Sen Phe Leu Thr Ser Lys Arg Lys Tyr Sen 140 Ile Val1 Ala Leu Ser Leu Gly Gly His Gly Lys Giu Leu Ala Giu Val 110 Lys Val 125 Asn Pro Giu Lys Ile Val Leu Val 190 Leu Met 205 Giu Gly Tyr Gly Pro Val Leu Asp Gly Leu 175 Val1 Ser Gin Val Ile Ala Lys Gly Lys Val Ile 160 Val1 Ile Tyr Ile Thr Leu Pro Leu Arg Val AMEDED SIEETI PCTUS 96/09122 IPENUS 8 DEC 1996 600 Phe Asn lle .Glu Ala Ser Ile Met Ser Leu Gly Gly Ile Ala Ile Ala 210 215 220 Ile Gly Ala Met Val Asn Ala Ala Ile Val Met Val 225 230 235 INFORMATION FOR SEQ ID NO:720: SEQUENCE CHARACTERISTICS: LENGTH: 175 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...175 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:720 Val Glu Thr Phe Leu Arg Ile Phe Glu Lys Asp Ile Phe Asn Thr Pro 1 5 10 Tyr Lys Leu Glu Val Ile Asn Ala Thr Glu Gly Gly Ala Arg Ile Lys 25 Gly Thr Lys Glu Met Pro Phe Lys Glu Val Cys Glu Lys Ile Asp Lys 40 Ser Lys Pro Lys Pro Pro Ile Asn Leu Ile Tyr Pro Thr Gln Ser Glu 55 Gin Ala Lys Asn Leu Lys Ile Ala Lys Lys Lys Cys Glu Glu Ile Ile 70 75 Lys Tyr Ala Asn Glu Lys Lys Thr Gin Val Glu Glu Ala Phe Leu Lys 90 Val Ala Glu Phe Leu Glu Lys Val Glu Lys Leu His Glu Lys Asn Lys 100 105 110 Leu Glu Glu Leu Asp Phe Glu Glu Leu Glu Asn Leu Ser Ala Glu Ile 115 120 125 Asp Asn Val Lys Glu Leu Phe Asp Asp Lys Arg Phe Asn Ser Tyr Phe 130 135 140 Met Asp Ala Ile Gin Ser Tyr Ile Phe His Gin Glu Leu His Ile Ala 145 150 155 160 Glu Ile Val Cys Lys Lys Thr Ser Asn Glu Asp Gly Ile Lys Gly 165 170 175 INFORMATION FOR SEQ ID NO:721: SEQUENCE CHARACTERISTICS: LENGTH: 226 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: POUS 96/091.2 I PENdS 18 D E C-9 9 601 NAME/KEY: misc_feature LOCATION .226 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:721 Met Lys Thr Pro Cys Asn Ala Tyr Phe Leu Lys Thr 1 Lys Leu Pro Giu Ala Arg Asn Lys Gly 145 Lys Phe Lys Met Thr 225 Lys Ala Leu Ile Phe Gly Thr Lys 130 Phe Tyr Asp Giy Unk 210 Leu Arg Ser Val1 Leu Gly Asp Leu 115 Arg As n Ala Phe Leu 195 Ile Arg Ala Val Ser Ile Phe 100 Lys Tyr Asn Ile Gly 180 Ile As n Tyr Trp Thr Leu 70 C ly Leu Pro Lys Tyr 150 Thr Glu Ala Arg Val1 Leu Lys 55 Leu Gly Tyr Leu Glu 135S Ser Phe Unk Tyr Tyr 215 Asn Ile 40 Pro Glu Thr Val1 Thr 120 Phe Leu Ser Asp Arg 200 Lys Leu 25 Pro Ser Lys Met Glu 105 Gin Asn Ala Asp Phe 185 Phe Ser Ala Arg Ser His Asn Tyr Lys Leu Ile Leu 170 Phe His Phe Val Ser Glu His 75 Ile Thr Val1 Leu Ser 155 Ala Glu Phe Giu Phe Ala Gin Ile His dly Asp Trp 140 Lys Phe Arg Arg Ser 220 Pro Leu Ile Tyr Pro Pro Thr Phe 125 Val1 Giu His Glu Ser 205 Leu Pro Phe Glu Ile Ile Ala Ala 110 Giu dly Asp Ser Asp 190 Leu Ile Lys Leu Unk Leu Lys Leu Trp Thr Leu Ala Pro Ala His Arg Asn Leu Lys Gly Arg Ile Val Ile Leu Gin 160 Asn Phe G lu Unk INFORMATION FOR SEQ ID NO:722: SEQUENCE CHARACTERISTICS: LENGTH: 79 amino acids TYPE: amino acid TOPOLOGY: linear (ii).MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: I(A) ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .79 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:722 Met Val Tyr Lys Leu Pro Lys His Gin Gin 5 10 Gly Leu Gly Leu Ala Met Ile Thr Arg Ile 25 Phe Phe Ile Ser His Leu Gin Lys Pro Leu 40 Ser Phe Ser Trp Arg Asp Val Val Leu Leu 55 Val
I
Leu Leu tsn Lys Val Met Ile is Gly Leu Leu Gly Ser Phe Ala Ile Ala Gly Leu Gly Giy Ala Phe |pEAA 602 Leu Ala Phe Lys Ala Leu Val Glu Leu Lys Arg Ala Asp Leu Ser 70 INFORMATION FOR SEQ ID NO:723: SEQUENCE CHARACTERISTICS: LENGTH: 64 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein {iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...64 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:723 Val Lys Phe Ser Val Leu Thr Leu Phe Pro Gin Leu Ile Leu Pro Tyr 1 5 10 Phe Glu Asp Ser Ile Leu Lys Arg Ala Leu Glu Lys Asn Leu Phe Glu 25 Leu Glu Val Leu Asn Leu Arg Asp Phe Ser Ala Asn Lys Tyr Gln Lys 40 Ala Unk Ser His Ala His Trp Trp Gly Cys Gly Ala Asn Phe Arg Pro 55 INFORMATION FOR SEQ ID NO:723: SEQUENCE CHARACTERISTICS: LENGTH: 64 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...64 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:723 Val Lys Phe Ser Val Leu Thr Leu Phe Pro Gln Leu Ile Leu Pro Tyr 1 5 10 Phe Glu Asp Ser Ile Leu Lys Arg Ala Leu Glu Lys Asn Leu Phe Glu 25 Leu Glu Val Leu Asn Leu Arg Asp Phe Ser Ala Asn Lys Tyr Gln Lys 40 Ala Unk Ser His Ala His Trp Trp Gly Cys Gly Ala Asn Phe Arg Pro 55 INFORMATION FOR SEQ ID NO:724: Cw) ft.Ir.%yIFT PCTIU3 c' 09122 |h6 Jl DE'1996 603 SEQUENCE CHARACTERISTICS: LENGTH: 138 amino acids TYPE: amino acid TOPOLOGY: linear (ii)-MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...138 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:724 Leu Trp Arg Thr Pro Lys Thr Pro Leu Val Ile Lys Pro Tyr Leu Lys 1 5 10 Ser Met Ser Asp Ser Glu Ile Phe Ala Unk Unk Cys Val Gly Met Ala 25 Ser Val Unk Gly Pro Val Leu Ala Gly Tyr Ala Ser Met Gly Ile Pro 40 Leu Pro Tyr Leu Ile Ala Ala Ser Phe Met Ser Ala Pro Gly Gly Leu 55 Leu Phe Ala Lys Thr Ile Tyr Pro Gln Asn Glu Thr Ile Ser Ser His 70 75 Ala Asp Val Ser Ala Glu Glu His Val Asn Ile Ile Glu Ala Unk Ala 90 Unk Gly Ala Ser Thr Gly Unk His Leu Ala Leu His Val Gly Ala Met 100 105 110 Leu Leu Ala Phe Val Gly Met Val Ala Leu Val Asn Gly Leu Leu Gly 115 120 125 Val Val Gly Gly Phe Leu Gly Met Glu His 130 135 INFORMATION FOR SEQ ID NO:724: SEQUENCE CHARACTERISTICS: LENGTH: 138 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...138 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:724 Leu Trp Arg Thr Pro Lys Thr Pro Leu Val Ile Lys Pro Tyr Leu Lys 1 5 10 Ser Met Ser Asp Ser Glu Ile Phe Ala Unk Unk Cys Val Gly Met Ala 25 Ser Val Unk Gly Pro Val Leu Ala Gly Tyr Ala Ser Met Gly Ile Pro 40 AMENDED
SHEET,
PCTi 12 2 604 Leu Pro Tyr-Leu Ile Ala Ala Ser Phe Met Ser Ala Pro Gly Gly Leu 55 Leu Phe Ala Lys Thr Ile Tyr Pro Gln Asn Glu Thr Ile Ser Ser His 70 75 Ala Asp Val Ser Ala Glu Glu His Val Asn Ile Ile Glu Ala Unk Ala 90 Unk Gly Ala Ser Thr Gly Unk His Leu Ala Leu His Val Gly Ala Met 100 105 110 Leu Leu Ala Phe Val Gly Met Val Ala Leu Val Asn Gly Leu Leu Gly 115 120 125 Val Val Gly Gly Phe Leu Gly Met Glu His 130 135 INFORMATION FOR SEQ ID NO:725: SEQUENCE CHARACTERISTICS: LENGTH: 210 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...210 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:725 Met Phe Val Val Phe Ile Glu Gly Phe Gly Leu Ala Ile Ser Leu Cys 1 5 10 Ala Ala Val Gly Ala Gln Ser Leu Phe Ile Val Glu Arg Gly Met Ala 25 Arg Asn Tyr Val Phe Leu Ile Cys Ala Leu Cys Phe Met Cys Asp Ile 40 Val Leu Met Ser Met Gly Val Phe Gly Val Gly Ala Tyr Phe Ala Lys 55 Asn Leu Tyr Leu Ser Leu Phe Leu Asn Leu Phe Gly Ala Val Phe Thr 70 75 Gly Phe Tyr Ala Phe Leu Ala Leu Lys Thr Leu Phe Gln Thr Phe Lys 90 Lys Lys Gln Val Gln Thr Pro Lys Lys Leu Ser Leu Lys Lys Thr Leu 100 105 110 Leu Phe Thr Leu Gly Val Thr Leu Leu Asn Pro Gln Val Tyr Leu Glu 115 120 125 Met Val Phe Leu Ile Gly Ala Ser Ala Met Ser Phe Asn Leu Val Gin 130 135 140 Lys Phe Val Phe Leu Ala Gly Thr Leu Ser Ala Ala Phe Ser Trp Leu 145 150 155 160 Leu Leu Leu Cys Thr Met Ser Leu Arg Tyr Gly Ser Lys Leu Leu Asn 165 170 175 Asn Gln Lys Ile Phe Met Gly Val Asn Leu Phe Val Thr Ala Ile Met 180 185 190 Gly Thr Leu Ser Val Thr Leu Phe Arg Asp Phe Leu Ala Leu Leu Ser 195 200 205 Lys Thr 210 INFORMATION FOR SEQ ID NO:726: AkArmom Qucm IPENS 18 DEC1996 605 SEQUENCE CHARACTERISTICS: LENGTH: 296 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1 .296 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:726 Val Lys Pro Lys Ser Met Lys Giu Lys Leu Arg 1 Ile Asp Leu Gin Ala Asn Pro Giu Val1 145 Arg Leu Tyr Val Phe 225 Giu Asn Tyr Leu Leu Asp Lys Ile Tyr Gly Lys Met 130 Ile Arg Thr Leu His 210 Leu Lys Leu Ala Asn 290 Arg Ala Pro Gin Pro Ala Ser 115 Leu Leu Leu Giu Lys .195 Ser Ile Giu Giu 275 Val1 5 Ile Lys Leu Asp Ile Ile Ala Gin Gin Phe Asn Met 100 Leu Tyr Met Arg Ile Asp Leu Asp 165 Ser Lys 180 Val Asn Asn Giu Gly Val Met Arg 245 Ser Giu 260 Phe Phe Glu Ile Met Lys Ser Phe 70 Leu Giu Ile Leu Ala 150 Lys Giu Leu Asn Asp 230 Ph.
Lys Lys I le Ile Val1 Pro 55 Thr Ser Phe Giu Leu 135 Lou Asn Ile Gin Ala 215 Ala Gly Asn Asp Ser 295 Giu Val2 40 Ile Asp Cys Leu His 120 Sen Ser Asn Giu Giu 200 Lys Lou Ser Asn Arg 280 Asp Ile 25 Ala Giu Ala Gly Leu 105 Giu Ser Leu Asp Giu 185 Lys Asp Ser Lys Gin 265 Thr 10 Ser Lys Asp Pro Leu 90 Pro Lys Ala dly Phe 170 Ala Leu Ser Lys Asn 250 Ser Ser Giu Lys Tyr Lys 75 Leu Lys Asp Pro Gly 155 Ile Leu Ala Leu Asp 235 Gly Ala Phe Gly Trp Giu Gin Phe Gin Val1 Gly Lou 140 Ile Tyr Lys Gly Pro 220 Ala Val1 Giu Glu Ala Leu Pro Lys As n Val1 Tyr Gin 125 Val1 Phe Gin His Phe 205 Leu Leu Leu Asp Unk 285 Met Gin Giu Sen Giu Ang Pro 110 Phe Gin Asn Gin Lou 190 Arg Lys Tyr Sen Lou 270 Leu Val1 1s Lys Ser Val1 Giu Gly Pho Leu Lou Leu Arg 175 His Asp Ala Tyr Ph.
255 Lys Lys Asn Lou Ph.
Arg Gly Lys Pro Arg Giu Ala 160 I le Glu Ph.
Lou Lou 240 Val1 Anrg Tyr INFORMATION FOR SEQ ID NO:727: SEQUENCE CHARACTERISTICS: LENGTH: 94 amino acids TYPE: amino acid TOPOLOGY: linear PT/'JS 9 /09122 IPEA/US 18 DEC 1996 (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...94 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:727 Leu Ile Ser Val Met Ile Gly Gin Asn Gin Val 10 Thr Asn Phe Lys Gln Glu Leu Val Val Asp Phe 25 Glu Ile Asn Ile Gly Asn Gln Val Ile Thr Ser 40 Phe Gly Ala Gly Val Phe Val Gly Glu Val Ser 55 Tyr Thr Tyr Lys Ser Ala Val Leu Lys Asn Ala 75 Lys Leu Leu Arg His Val Phe Leu Ser Gly Val Leu Ile Gly Ser Phe Lys Gly Phe Ile Val Pro Ser Leu Asp Gly Val Glu Asp Leu Ser Glu Asn INFORMATION FOR SEQ ID NO:728: SEQUENCE CHARACTERISTICS: LENGTH: 83 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...83 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:728 Met Glu Ala Gln Leu Arg Phe Thr Gly Val Gly Gly Gin Gly Val Leu 1 5 10 Leu Ala Gly Glu Ile Leu Ala Glu Ala Lys lie Val Ser Gly Gly Tyr 25 Gly Thr Lys Thr Ser Thr Tyr Thr Ser Gin Val Arg Gly Gly Pro Thr 40 Lys Val Asp Ile Leu Leu Asp Lys Asp Glu Ile Ile Phe Pro Tyr Ala 55 Lys Glu Gly Glu Ile Asp Phe Met Leu Ser Val Ala Gln Ile Ser Tyr 70 75 Asn Gin Phe INFORMATION FOR SEQ ID NO:729: SEQUENCE CHARACTERISTICS: PCT/US 9 6 091 2 IPEA/US 18 DEC 1996 607 LENGTH: 203 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...203 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:729 Met Gln Ala Trp Val Asp Lys Pro Val 1 Ala Pro Glu Val Gly Val Tyr Ser Phe 145 Lys Gly Leu Tyr Leu Leu Ile Ile Pro Ile 115 Cys Thr Tyr Ile Ser 195 Ala Ala Ala Gly Val Ser 100 Phe Met Ser Leu Pro 180 Gin 5 Ala Cys Asp Ser Lys Lys Gly Gly Thr Gly 165 Thr Lys Val Pro Thr Cys 70 Asn Met Ala Asn Arg 150 Ser Lys Asp Ile Asn Thr Met Ala Asp Ala Gin 135 Asn Ala Glu Lys Glu Asp 40 Gly Thr Pro Glu Gly 120 Ala Phe Glu Glu Ile 200 Leu Leu Glu Pro Asp Ser Asn 10 Asp Val Ala Glu Ile Thr Glu Asp Asp Val Ala Thr Leu Ser Arg Pro His Ala Ile Asp Glu Ile Gly His Phe Arg Ala Phe 75 Ser Gln Ala Arg Leu Trp Val 90 Glu Leu Ile Asn Glu Gly Tyr 110 Arg Thr Glu Val Pro Gly Cys 125 Val Arg Asp Asn Ala Val Val 140 Asn Arg Met Gly Arg Gly Ala 155 160 Gly Ala Ala Cys Ala Leu Leu 170 175 Met Asn Leu Val Ser GIu Lys 190 Arg Ser INFORMATION FOR SEQ ID NO:730: SEQUENCE CHARACTERISTICS: LENGTH: 220 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...220 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:730 IPENU S 18 299 Val Gly Asn.Ala Gly Val Ala Leu Ala Tyr Ala Leu Ser Tyr His Lys Asn Lys 145 Glu Ser His Glu Leu Gin Ile Leu Gin Ala Gin His 130 Glu Ala Ala I le Leu 210 Cys Asn Ser Phe Pro Val1 Asp 115 Ala Asp Phe Lys Leu 195 Thr Ala L4 Ser T Vai G, Leu Li Lys L) Ser L( 100 Ala IJ Lys As Phe PI Giu Ti Thr P3 180 Gin S( Leu L( Asp Ty Ser 70 Val Asn Val Leu Thr 150 Val Thr Val1 Ser Cys Gly As n 55 Lys Tyr His Arg Lys 135 His Asp Ile Leu Asn 215 Ala Asp 40 Val1 Giu Asn Ser Ile 120 Asn Leu Ser Gly Ile 200 Ser Tyr 25 Glu Giu Arg Leu Gin 105 Lys Leu Asn Leu Ile 185 Val1 Leu Giy Leu Ile Lys Lys Giu Gly Tyr Ile Giu Ser Tyr Val Lys Ser Met Gin Lys Thr Pro Ser Gly 170 Leu Phe Ser Leu Lys Thr Met Gly Ile Glu Giu Gly Leu Phe Asn 140 Cys Phe Glu His Pro 220 Ser Phe Asp Thr Ala Ala Lys Ser 125 Leu Lys Cys Gly Leu 205 Asp Lys Thr Phe Leu Lys Gin 110 Pro Ile Thr Gin Ser 190 Lys INFORMATION FOR SEQ ID NO:731: SEQUENCE CHARACTERISTICS: LENGTH: 116 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix).FEATURE: NAME/KEY: misc-feature LOCATION 1 .116 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:731 Met Asn Phe Phe Val Gly Gly Leu Ser Ile Val 10 Ile Thr Tyr Ser Ala Lou His Pro Thr Ala Pro 25 Asp Ilie Val Gin Val Sen His His Leu Thr Sen 40 *Thr Gly Lou Leu Phe Gly Phe Thn Tyr Leu Tyr 55 Thr Phe Gly Lou Asp Trp Arg Pro Tyr Ser Trp 75 *Ala Ile Asn Thr Val Pro Ala Ala Ile Leu Ser 90 *Lou Asp Asp His Lys Val Lou Gly Ile Thn Giu 100 105 Ile Ile Unk Val Val Glu Ala His Val Met Ala r~L) Cys Val1 Phe Ala Tyr His Gly Asn Giu Tyr Ala Ser Tyr Asp 110 Val Val Gly Ala Gly Pro Ile Asn Leu Phe Ser Asp Trp Trp IPENUS 18 DEC1996 115-.
INFORMATION FOR SEQ ID NO:731: SEQUENCE CHARACTERISTICS: LENGTH: 116 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...116 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:731 Val Met Asn Phe Phe Val Gly Gly Leu Ser Ile Val 1 5 10 Val Ile Thr Tyr Ser Ala Leu His Pro Thr Ala Pro 25 Glu Asp Ile Val Gin Val Ser His His Leu Thr Ser 40 Ala Thr Gly Leu Leu Phe Gly Phe Thr Tyr Leu Tyr 55 His Thr Phe Gly Leu Asp Trp Arg Pro Tyr Ser Trp 70 75 Val Ala Ile Asn Thr Val Pro Ala Ala Ile Leu Ser 90 Met Leu Asp Asp His Lys Val Leu Gly Ile Thr Glu 100 105 Ala Ile Ile Unk 115 Cys Val Phe Ala Tyr His Gly Asn Glu Tyr Ala Ser Tyr Asp 110 Val Val Gly Ala Gly Pro Ile Asn Leu Phe Ser Asp Trp Trp INFORMATION FOR SEQ ID NO:732: SEQUENCE CHARACTERISTICS: LENGTH: 248 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...248 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:732 Met Gin Lys Ser Ile Phe Lys Ile Thr Leu Leu Leu Val Phe Leu Phe 1 5 10 Leu Arg Asn Ala Val Gly Leu Asp Asp Lys Lys Ala Ala Pro Lys Ser 25 Av, 111; -'I'll-tl 0 1r.6-T
PC
IPENUS 18 DEC1996 610 Val Gln Asn Thr Pro Lys Asn Leu Pro Pro Ile Gln Leu Arg Leu Asp 40 Gin Ala Tyr Glu Asp Leu Ile Lys Met Leu Asp Asn Met Gly Lys Ser 55 Thr Gln Tyr Glu Phe Pro Lys Ile Lys Glu Ile Leu Glu Gin Ser Glu 70 75 Glu Glu Trp Leu Gly Val Ala His Glu Glu Cys Val Ala Leu Val Met 90 Leu Ile Ser Pro Lys Ala Ser Ile Glu Asn Ser Pro Ile Tyr Lys Asn 100 105 110 Cys Tyr Glu Ala Tyr Val Lys Gln Arg Ile His Asp Leu Tyr Asp Phe 115 120 125 Tyr Ile Glu Gly Lys Lys Val Lys Arg Lys Ile Lys Lys Ala His Glu 130 135 140 His Glu Met Ala Leu Asn Lys Ser Gln Pro Leu Lys Lys Glu Pro Pro 145 150 155 160 Lys Ser Glu Asn Lys Lys Gly Leu Thr Lys Pro Ser Leu Lys Asp Ala 165 170 175 Lys Ile Pro Lys Gly Tyr Tyr Leu Gln Ile Gly Ala Phe Leu Asn Ser 180 185 190 Pro Ser Lys Asp Phe Leu Gln Thr Leu Lys Thr Phe Pro His Gln Met 195 200 205 Glu Glu Lys Asp Ser Leu Thr His Tyr Leu Ile Gly Pro Tyr Lys Thr 210 215 220 Lys Glu Giu Ala Leu Lys Gin Leu Glu Asn Ala Ala Lys Ser Phe Lys 225 230 235 240 Asn Lys Pro Ala Leu Val Glu Lys 245 INFORMATION FOR SEQ ID NO:733: SEQUENCE CHARACTERISTICS: LENGTH: 150 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) .FEATURE: NAME/KEY: misc_feature LOCATION 1...150 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:733 Met Gln Glu Ile Leu Ile Pro Leu Lys Glu Lys Ser Tyr Lys Val Phe 1 5 10 Leu Gly Glu Leu Pro Glu Ile Lys Leu Lys Gln Lys Ala Leu Ile Ile 25 Ser Asp Ser Ile Val Ala Gly Leu His Leu Pro Tyr Leu Leu Glu Arg 40 Leu Asn Ala Leu Glu Val Arg Val Cys Val Ile Glu Ser Gly Glu Lys 55 Tyr Lys Asn Phe His Ser Leu Glu Arg Ile Leu Asn Asn Ala Phe Glu 70 75 Met Gin Leu Asn Arg His Ser Leu Met Ile Ala Leu Gly Gly Gly Val 90 Ile Ser Asp Met Val Gly Phe Ala Ser Ser Ile Tyr Phe Arg Gly Ile 100 105 110 Asp Phe Ile Asn Ile Pro Tyr Asp Phe Thr Arg Ser Ser Gly Cys Gl.u
.L-
fP Nu S 18DEC19 9 115-. 120 125 Arg Gly Gly Glu Asn Arg Asp Gin His Ala Leu Trp Gin Giu Pro Asn 130 135 140 Arg Ile Val Pro Pro Ala 145 150 INFORMATION FOR SEQ ID NO:734: SEQUENCE CHARACTERISTICS: LENGTH: 227 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc-feature LOCATION .227 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:734 Val Lou Leu Gly 1 Ala Lou Glu Ile Phe Pro Ile Pro 'Asp Ala Giu Val Ser Val Giu Ilie 130 Leu Lys 145 Asn Asn Lou Ala Unk Ala Phe Lys 21.0 Lys Arg 225 Ser Thr Lys Lys Gly Ilie Gly 115 Ala Gly Leu Gly Ala 2.95 Asn Leu Phe Sen Lys Asp Val1 Lou 100 Ile Ang Ala Gly Leu 180 Ile tmnk Lys 5 Gly As n Leu Phe Phe Thr Asfl Asp Asn Ser 165 Ile Asn Unk Sen As n Sen Lys 70 Pro Ile Phe Thr 150 Val Val Ala Ala Gly Lys Ala 55 Lys His His Sen Ser 135 Leu Ala Ser Ser Lou 215 His Sen Gly Ala Giy Leu Leu Ser Ala Leu Unk Val Pro 40 Phe Trp Lys Pro Met 120 Gin Ile Leu Leu Leu 200 Val 25 Lou Ala Leu Giu Lys 105 Leu Lys Ala Ala Leu 185 Ala Ser Glu Leu Glu Val1 90 G iu G iu Tyr His Lys 170 Ser His Ile Leu Gly Leu 75 Lou Pho Lou Pro Gin 155 Ala Gin Ala Gin Val1 Met Ala Gin Leu Lou Lys 140 Gly Gly Asn Leu Leu 220 Ala Phe Giy Pro Ala Ser Asp 125 Val1 Arg Sen Tyr Ala 205 Lou Cys Leu Cys Lou Leu 1.10 Asn Val Val Gly Thr 2.90 Gly Glu Giu Glu Val1 Glu Leu Lys Leu Phe Asp 175 Pro Leu Cys Asn Asn Lou Lys Lys Lou Leu Ile 160 Val Leu Unk Unk Thr Pro Unk Asp Ile Glu Lys INFORMATION FOR SEQ ID NO:734: SEQUENCE CHARACTERISTICS: LENGTH: 227 amino acids TYPE: amino acid TOPOLOGY: linear PCT 96/091 2 tPEA S 18 DEC 1996 612 (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...227 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:734 Val Leu Leu Gly Lys His Ser Gly Ala Gly Leu Leu Ser Ala Leu Unk 1 5 10 Ala Leu Ser Phe Gly Ser Gly Val Val Ser Ile Gin Ala Leu Glu Cys 25 Glu Ile Thr Ser Asn Asn Lys Pro Leu Glu Leu Val Phe Cys Glu Asn 40 Phe Pro Lys Lys Leu Ser Ala Phe Ala Leu Gly Met Gly Leu GIu Asn 55 Ile Pro Lys Asp Phe Lys Lys Trp Leu Glu Leu Ala Pro Cys Val Leu 70 75 Asp Ala Gly Val Phe Tyr His Lys Glu Val Leu Gln Ala Leu Glu Lys 90 Glu Val Je Leu Thr Pro His Pro Lys Glu Phe Leu Ser Leu Leu Lys 100 105 110 Ser Val Gly Ile Asn Ile Ser Met Leu Glu Leu Leu Asp Asn Lys Leu 115 120 125 Glu Ile Ala Arg Asp Phe Ser Gln Lys Tyr Pro Lys Val Val Leu Leu 130 135 140 Leu Lys Gly Ala Asn Thr Leu Ile Ala His Gln Gly Arg Val Phe Ile 145 150 155 160 Asn Asn Leu Gly Ser Val Ala Leu Ala Lys Ala Gly Ser Gly Asp Val 165 170 175 Leu Ala Gly Leu Ile Val Ser Leu Leu Ser Gln Asn Tyr Thr Pro Leu 180 185 190 Unk Ala Ala Ile Asn Ala Ser Leu Ala His Ala Leu Ala Gly Leu Unk 195 200 205 Phe Lys Asn Unk Unk Ala Leu Thr Pro Unk Asp Leu Ile Glu Lys Unk 210 215 220 Lys Arg Leu 225 INFORMATION FOR SEQ ID NO:735: SEQUENCE CHARACTERISTICS: LENGTH: 187 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...187 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:735 (xi) SEQUENCE DESCRIPTION: SEQ ID N0:735 PQf/US 96/09122 IPE US 18 J E 1996 613 Met Arg Ile Leu His Tyr Gly Gly Glu Leu Pro Cys Asp Cys Pro Lys 1 5 10 Arg Ile Ala Gly Leu Asp Phe Ala Leu Lys Ile Leu Thr Asn Ile Thr 25 Ser Asp His Leu Asp Phe His Gin Asn Ile Glu Asn Tyr Arg Asp Ala 40 Lys Asn Ser Phe Phe Lys Asp Glu Gly Leu Lys Val Ile Asn Arg Asp 55 Glu Thr Asn Ala Leu Phe Asn Pro Ile Asn Ala Arg Thr Tyr Ala Leu 70 75 Asp Lys Lys Ala His Leu Asn Val Gin Ala Phe Ser Leu Asn Pro Ser 90 Ile Ser Ala Ser Leu Cys Tyr Gln His Asp Leu Arg Asp Pro Asn Leu 100 105 110 Lys Glu Thr Ala Leu Ile His Ser Pro Leu Leu Gly Arg Tyr Asn Leu 115 120 125 Tyr Asn Ile Leu Ala Gly Val Leu Gly Val Lys Leu Leu Thr Gln Leu 130 135 140 Pro Leu Glu Thr Ile Ala Pro Leu Leu Glu Asn Phe Tyr Gly Val Lys 145 150 155 160 Gly Arg Leu Glu Ile Val His Ser Lys Pro Leu Val Val Val Asp Phe 165 170 175 Ala His Thr Thr Asp Gly Met Gln Gln Val Phe 180 185 INFORMATION FOR SEQ ID NO:736: SEQUENCE CHARACTERISTICS: LENGTH: 198 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...198 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:736 Val Ser Ile Lys Glu Glu Ser Gin Thr Leu Ala Asp Ile Thr Phe Gin 1 5 10 Asn Tyr Phe Arg Met Phe Ser Lys Leu Ser Gly Met Thr Gly Thr Ala 25 Gin Thr Glu Ala Thr Glu Phe Leu Glu Ile Tyr Asn Leu Glu Val Val 40 Ser Ile Pro Thr Asn Leu Ala Ile Lys Arg Lys Asp Leu Asn Asp Leu 55 Ile Tyr Lys Ser Glu Lys Glu Lys Phe Asp Ala Val Ile Leu Lys Ile 70 75 Lys Glu Leu His Asp Lys Gly Gln Pro Val Leu Val Gly Thr Ala Ser 90 Ile Glu Lys Ser Glu Thr Leu His Ala Leu Leu Lys Lys GIu Arg Ile 100 105 110 Pro His Thr Val Leu Asn Ala Lys Gln His Thr Lys Glu Ala Glu Ile 115 120 125 Ile Lys Asp Ala Gly Leu Lys Gly Ala Val Thr Ile Ala Thr Asn Met 130 135 140 PCT/uS c 6/091 ?2 IPENUS 18 U 1996 Ala 145 Gly Asp Ser 614 Gly Arg Gly Val Asp Ile Lys Leu Thr Asp Glu Val 150 155 Gly Leu Tyr Ile Ile Gly Thr GIu Arg His Glu Ser 165 170 Asn Gin Leu Arg Gly Arg Ser Gly Arg Gin Gly Asp 180 185 Gin Phe Tyr Leu Ser 195 Lys Glu Leu 160 Arg Arg Ile 175 Pro Gly Val 190 INFORMATION FOR SEQ ID NO:737: SEQUENCE CHARACTERISTICS: LENGTH: 208 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...208 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:737 Val Val Ala Asp Glu Val Arg Lys Leu Ala Glu Lys Thr Gin 1 Thr Asp Lys Val Phe Tyr Lys Asn Ser 145 His Asp Lys Lys Ile Gly Ala Cys Gly Ser Phe 130 Val Val Ser Gin Glu Gin Asp Gin Gly Met Unk 115 Ala His Thr Ala Asp 195 Ile Thr Val Ala Unk Val 100 Arg Asn Ala Asp Lys 180 Glu 5 Ala Asn Glu Ala Ala Unk Leu Thr Glu Ser 165 His Leu Val Thr Glu Lys 70 Lys Leu Gly Ser Ala 150 Lys Val Asn Val His Leu 55 Tyr Leu Val Lys Gly 135 Asn Tyr Lys Lys Val Asp 40 Lys Thr Asp Ser Trp 120 Tyr Asp Leu Glu Ile 200 Lys 25 Ile Ser Ile His Ile 105 Tyr Arg Leu Glu Asn 185 Ile 10 Ser Asn Thr Tyr Val 90 Pro Tyr Ala Val His 170 Ile Glu Met Ser Val Asn 75 Val Leu Glu Leu Lys 155 Lys Asp Lys Gin Ile Lys Ile Phe Thr Gly Glu 140 Ala Val Lys Ile Gin Val Asn Asn Lys Leu Ala 125 Ser Val His Met Gin 205 Glu Gly Asn Asn Asn Pro 110 Gly His Gin Leu Phe 190 Lys Lys Ala Ala Asn Ser Ile Met Ile Arg Val Asn Leu Ala His Lys Glu His Ala Glu Asp 160 Met Glu 175 Tyr Glu Gly Glu INFORMATION FOR SEQ ID NO:738: SEQUENCE CHARACTERISTICS: LENGTH: 201 amino acids TYPE: amino acid TOPOLOGY: linear PCTJUS 9 6 091 2.
PEA S 18 UE 1996 615 (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...201 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:738 Met Asn Thr Ser Lys Lys Leu Gly Asn Pro Leu Leu Phe Leu His Asp 1 5 10 Asn Lys Ile Leu Leu Phe Val Val Gly Val Ser Met Gly Gly Trp Ala 25 Thr Ser Lys Ile Tyr Gln Phe Glu Ser Ala Leu Glu Pro Ile His Phe 40 Lys Phe Ala Arg Lys Leu Ser Leu Ser Pro Phe Leu Asn Leu Ser His 55 Leu Val Arg Asn Lys Pro Leu Asn Thr Thr Asp Gly Gly Phe Met Leu 70 75 Pro Leu Tyr His Glu Leu Ala Thr Gin Tyr Pro Leu Leu Leu Lys Phe 90 Asp Gin Gln Asn Asn Pro Arg Glu Leu Leu Arg Pro Asn Thr Leu Asn 100 105 110 His Gln Leu Gin Pro Ser Leu Thr Pro Phe Lys Asp Cys Ala Val Met 115 120 125 Ala Phe Arg Asn His Ser Phe Lys Asp Ser Leu Met Leu Glu Thr Cys 130 135 140 Lys Thr Pro Thr Asp Trp Gln Lys Pro Ile Ser Thr Asn Leu Lys Asn 145 150 155 160 Leu Asp Asp Ser Leu Asn Leu Leu Asn Leu Asn Gly Ile Leu Tyr Leu 165 170 175 Ile His Asn Pro Ser Asp Leu Ser Leu Arg Arg Lys Glu Leu Trp Leu 180 185 190 Ser Lys Leu Glu Asn Gln Gln Leu Ile 195 200 INFORMATION FOR SEQ ID NO:739: SEQUENCE CHARACTERISTICS: LENGTH: 127 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...127 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:739 Met Ser Ile Gin His Phe Arg Val Ala Leu Ile Pro Phe Phe Ala Ala 1 5 10 Phe Cys Leu Pro Val Phe Ala His Pro Glu Thr Leu Val Lys Val Lys 25 -PCTIU~ 06/91 ffEMS 18 DEC 1996 Asp Leu Pro Arg Gin Asp Ala Asn Met Ile Asn Gly Giu .Asp Ser Giy Met Ser Leu Ile Phe 70 Gin Giu Arg Giy LeU 55 Lys Giu Tyr Glu Aia 40 G iu Val1 Gin Ser Leu 120 Arg Ser Leu Leu Pro 10s Ser Val1 Phe Leu Gly 90 Val Arg 616 Giy Tyr Arg Pro Cys Gly 75 Arg Arg Thr Giu Trp Cys Ile Giu Giu Giu Ala Val Ile His Lys His 110 His Asn 125 Leu Arg Leu Tyr Leu His Asp Phe Ser Ser Thr INFORMATION FOR SEQ ID NO:740: SEQUENCE
CHARACTERISTICS:
LENGTH: 79 amino acids TYPE: amino acid TOPOLOGY: iinear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylor.
(ix) FEATURE: NAME/KEY: misc_feature LOCATION .79 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:740 Val Asn Val Giy Val Pro Phe Sen Tyr Gin Val Ser Ala Thr Phe Gin 1 5 10 Asn Sen Ang Leu Ser Ser Leu Leu Glu Thr Leu Lys Lys Ser Phe Leu 25 Giu Lys Pro Leu Ile Glu Ser Ser Ala Asn Lys Ile Ala Asp Ile Phe 40 Sen Lys Ala Val Leu Ph. Leu Ala Phe Val Sen Ph. Leu Leu Trp Gin 55 Phe Gly Leu Gly Gly Asn Ph. Glu Lys Ser Phe Asn Gly Val Tyr 70 INFORMATION FOR SEQ ID NO:741: SEQUENCE
CHARACTERISTICS:
LENGTH: 49 amino acids TYPE: amino acid CD) TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc-feature LOCATION .49 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:74i ~OAAIMfl
APVI
PCT/UJS 96/091z2 IPEA/S 18 uL 1996 Met Leu Met Val Asn Gly Tyr Gin Ile Thr Met His Lys Gly Tyr Lys 1 5 10 Val Gly Phe Phe Thr Ser Gly Tyr Asn Pro Asp Phe Ala Gin Thr Ile 25 Gin Asn Arg Ser Tyr Leu Met Ser Ser Tyr GIu Leu Ser Phe Leu Arg 40 Asn INFORMATION FOR SEQ ID NO:742: SEQUENCE CHARACTERISTICS: LENGTH: 412 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...412 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:742 Met Val Gln Phe Gin Asn Thr Leu Ile Lys Phe His Ala Leu Ser Phe 1 Lys Lys Glu Lys Asn Ser Val Pro Met 145 Asn Asp Asn Lys Gly 225 Gin Asn Glu Asp Asp Gin Ala Lys Lys 130 Ile Leu Ala Ala Ala 210 Gin Met Ala Asn Val Ile Leu Ile Ala 115 Pro Ser Ser Asp Asp 195 Phe Ser Leu Asn Ser Leu Val Gly Leu 100 Leu Thr Ser Ile Val 180 Val Gly Leu Ser 5 Leu Asn Asn Ser Leu Arg Asn Thr Gly Ala 165 Tyr Ile Val Ile Asp 245 Ile Thr Ala Phe 70 Leu Glu Leu Lys Lys 150 Leu Gly Met Ser Trp 230 Ile Tyr Ile Leu 55 Gly Ile Asn Asp Asn 135 Gly Ala Pro Asp Val 215 Arg Ile Asn Ile 40 Lys Phe Glu Ile Ile 120 Leu Gly Asn Asn Pro 200 Met Gly Trp Ala 25 Leu Thr Val Ile Ser 105 Lys Ala Val Leu Ile 185 Ser Ser Pro Gly 10 Lys Arg Ile Lys Pro 90 Lys Thr Lys Gly Asn 170 Pro Gly Met Met Asp 250 Leu Ile Ile Asn 75 Ser Ala Pro Asn Lys 155 Gin Ar Lys Gly Leu 235 Leu Asn I Lys Tyr Ile Ser Met Pro Ile 140 Ser Lys Met Lys Leu 220 Met Asp .ys 4et Pro Thr Ser Gin Lys 125 Lys Thr Val Met Leu 205 Leu Arg Val Thr Leu Asn Leu Glu Glu 110 Pro His Thr Gly Gly 190 Ile Tyr Ala Leu Cys Thr Phe His Glu Lys Gin Val Ser Leu 175 Leu Pro Asp Ile Val Tyr 31n Glu Asp Thr Gly Ala Val Val 160 Leu Gin Leu Glu Glu 240 Val Asp Met Pro Pro Arg Asn Arg Arg Cys Ala Ala His Ala 255 Ala Gln Ala 270 PCT/US 9 6 091 2 IPEAUS 18DEC 1996 618 Val Pro Leu-Ser Ala Gly Ile Thr Val Thr Thr Pro Gln Ile Val Ser 275 280 285 Leu Asp Asp Ala Lys Arg Ser Leu Asp Met Phe Lys Lys Leu His Ile 290 295 300 Pro Ile Ala Gly Ile Val Glu Asn Met Gly Ser Phe Val Cys Glu His 305 310 315 320 Cys Lys Lys Glu Ser Glu Ile Phe Gly Ser Asn Ser Met Ser Gly Leu 325 330 335 Leu Glu Ala Tyr Asn Thr Gin Ile Leu Ala Lys Leu Pro Leu Glu Pro 340 345 350 Lys Val Arg Leu Gly Gly Asp Lys Gly Glu Pro Ile Val Ile Ser His 355 360 365 Pro Thr Ser Val Ser Ala Lys Ile Phe Glu Lys Met Ala Lys Asp Leu 370 375 380 Ser Ala Phe Leu Asp Lys Val Glu Arg Glu Lys Leu Ala Asp Asn Lys 385 390 395 400 Asp Ile Gln Pro Thr Gln Thr His Ala Tyr Ser His 405 410 INFORMATION FOR SEQ ID NO:743: SEQUENCE CHARACTERISTICS: LENGTH: 89 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...89 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:743 Met Gly Val Val Ile Gly Glu Thr Thr GIu Ile Gly Asp Asp Val Thr 1 5 10 Ile Tyr His Gly Val Thr Leu Gly Gly Thr Gly Lys Phe Lys Gly Lys 25 Arg His Pro Thr Leu Gly Asn Arg Val Val Val Gly Ala Gly Ala Lys 40 Val Leu Gly Ala Ile Cys Val Gly Asp Asp Val Arg Ile Gly Ala Asn 55 Ala Val Val Leu Ser Asp Leu Pro Thr Gly Ser Thr Ala Val Gly Ala 70 75 Lys Ala Lys Thr Ile Thr Lys Asp Arg INFORMATION FOR SEQ ID NO:744: SEQUENCE CHARACTERISTICS: LENGTH: 192 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein S(iii) HYPOTHETICAL: YES [r IPEN/US 18JC 1996 619 (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1 192 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:744 Met Leu Sen Phe Ile Ser Ala Phe Asp Lys Arg
I
Leu Leu Ile Val1 Ala Met Thr Leu Ile 145 Ile Pro Leu Giu Gin Val1 Asn Ser Gin Lys 130 Giu Lys Asp Thr Ile Ala Ser Val1 Leu Sen 115 Lys Asn Asn Leu Ala Gin Leu Lys Se r Gly 100 Lys Thr Tyr Leu Ile 180 Leu Val1 Gin 55 Asn Phe Gin As n Gin 135 Gin Thr Asp Leu Ala Ile Pro Arg Lys Leu 120 Leu Gin Leu Lys Phe Lys Asp Ile Leu Val1 105 Giu Val1 Giu Tyr Leu 185 10 Ser Tyr Ala Leu Asp Asp Lys Ile Ile Gin 170 Glu Leu Leu Leu Tyr Ser Leu Gin Asn Giu 155 Ala Asn Gly Gly Ser Asp Leu Thr Asn Lys Leu 140 Leu Asn Leu Ile Lys Gin Giu Asn Gin Lys Leu Asn Thr Ser 175 Ala INFORMATION FOR SEQ ID NO:745: SEQUENCE CHARACTERISTICS: LENGTH: 109 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii). HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .109 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:745 Val Unk Leu Tyr Leu Ala Leu Thr Leu Ser Leu Gly Ile Ala Met Leu 1 5 10 Leu Val Glu Met Leu Ile Gly Asn Leu Gly Lys Lys Asp Val Val Sen 25 Asn Tyr Gin Ile Leu Asp Pro Lys Ang Lys Lys Tyr Tyr Pro Phe Thr 40 Sen Phe Phe Ile Leu Gly Gly Pro Leu Ile Leu Sen Phe Tyr Ala Val 55 Val Leu Gly Tnp Val Leu Tyr Tyr Leu Phe Val Val Thr Phe Asp Leu 70 75
-O
.7 ~'VT O~ 96/09122 PEAS18 DEC 199 6 620 Pro Lys Asp Leu Unk Gin Ala Lys Met Gin Phe Unk Met Leu Gin Asn 90 Gly Ser Leu Ile Trp Pro Val Ile Asp Phe Ser Ala Cys 100 105 INFORMATION FOR SEQ ID NO:745: SEQUENCE CHARACTERISTICS: LENGTH: 109 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION 1...109 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:745 Val Unk Leu Tyr Leu Ala Leu Thr Leu Ser Leu Gly Ile Ala Met Leu 1 5 10 Leu Val Glu Met Leu Ile Gly Asn Leu Gly Lys Lys Asp Val Val Ser 25 Asn Tyr Gin Ile Leu Asp Pro Lys Arg Lys Lys Tyr Tyr Pro Phe Thr 40 Ser Phe Phe Ile Leu Gly Gly Pro Leu Ile Leu Ser Phe Tyr Ala Val 55 Val Leu Gly Trp Val Leu Tyr Tyr Leu Phe Val Val Thr Phe Asp Leu 70 75 Pro Lys Asp Leu Unk Gin Ala Lys Met Gln Phe Unk Met Leu Gln Asn 90 Gly Ser Leu Ile Trp Pro Val Ile Asp Phe Ser Ala Cys 100 105 INFORMATION FOR SEQ ID NO:746: .SEQUENCE CHARACTERISTICS: LENGTH: 116 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...116 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:746 Val Pro Ala Val Gly Gly Ala Leu Ile Trp Unk Unk Ile Unk Ile Tyr 1 5 10 7\Glu Leu Tyr His Gly Unk Val Asn Glu Unk Ile Phe Unk Val Leu Tyr ffAAS 18 D 1996 Ser Leu Asn Gly Ala Thr Ile Ile Giu Phe Leu Cys Leu tLeu Val Phe Ile Leu Trp Gly Leu Arg 100 Giu Cys 115 Ile Gly Val Leu 40 Ile Lys Lys Arg 55 Ile Phe Phe Ser 70 Ile Ile Val Gly Leu Tyr Giu Asn 25 Ile Asp Ser Ile Phe Lys Met Ile Ala 75 Pro Thr Ile 90 Tyr Phe Ile 105 Vai Ile Thr Thr Gly Ile Thr Ala Gin Lys Lys Leu Ser Phe Giu 110 Pro Lys Gin Phe Gin Ile Ile Phe Ile Lys INFORMATION FOR SEQ ID NO:747: SEQUENCE CHARACTERISTICS: LENGTH: 163 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION i. 63 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:747 Val Val Val Ile Ile Leu Val Val Vai Ile Ile 1 5 2.0 Leu Lys Giu Giu Arg Giu Gin Giu Arg Ala Ile 25 Asn Asn Sen Phe Asn Giu Thr Asn Pro Thr Giu 40 Pro Thn Pro Lys Leu Giu Giu Lys His Lys Giu 55 Lys Giu Aia Ile Lys Giu Asn Pro Asn Thr Ile 70 75 Arg Asp Ile Trp Val Giu Val Ile Asp Leu Asp 90 Phe Gin Lys Val Phe Lys Lys Sen Tyr Pro Leu 100 2.05 Arg Leu Leu Leu Arg Phe Gly His Gly His Leu .115 120 His Gin Giu Gin Asp Tyr Asn Asp Ser Lys Thn 130 135 Giu Pro Asn Lys Gly Leu Thr Leu Ile Asn Giu 145 150 i55 Leu Gin Gin Gin Lys Giu Gin Tyr Giu Giu Ile Arg i4 0 Ala Asn Sen Sen is Pro Asp Thr Lys Lys Leu Asp Lys Gin Ile Ile Pro Lys Lys Asn Aia Lys Asn 12.0 Leu Lys Asn 125 Arg Phe Leu Gin Tyr Lys Ser Lys Giu Gly Lys Ser His Asfl Tyr Ala 160 INFORMATION FOR SEQ ID NO:748: SEQUENCE CHARACTERISTICS: LENGTH: 40 amino acids TYPE: amino acid TOPOLOGY: iinear IPENUS 18 DE 1 996 622 (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...40 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:748 Met Asp Glu Ile Tyr Gin Ile Ala Lys Asn Lys Thr Leu Ile Val Ile 1 5 10 Ala His Arg Leu Ser Thr Ile Glu Arg Cys Glu Val Ile Ile Asp Met 25 Ser Gin His Lys Asp Asn Leu Gly INFORMATION FOR SEQ ID NO:749: ki) SEQUENCE
CHARACTERISTICS:
LENGTH: 45 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_ feature LOCATION 1...45 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:749 Val Ala Gly Ser Phe Ile Ile Ala Leu Phe Ser Val Leu Ala Asp Gin 1 5 10 is Phe Val Ser Val Phe Gin His Glu Asn Ala Leu Gin Arg Leu Phe Ser 25 Gin Asn Ala Thr Gln Lys Gin Lys Lys Lys Ser Leu Cys 40 INFORMATION FOR SEQ ID NO:750: SEQUENCE
CHARACTERISTICS:
LENGTH: 118 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: PCT/US 9S/091
Z
IPEA/US 18D 1396 623 NAME/KEY: misc_feature LOCATION 1...118 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:750 Met Val Ala Leu Ser Asn Ala Leu Ser Arg Val Phe Gly Ser Val Ala 1 5 10 Gly Tyr Lys Phe Pro Ser Phe Ile Gin Lys Ser Ile Asn Ala Leu Tyr 25 Val Lys Ile Phe Lys Ile Asp Leu Ser Glu Phe Glu Pro Leu Glu Asn 40 Tyr Lys Ser Leu Asn Ala Leu Phe Met Arg Ser Leu Lys Lys Glu Arg 55 Pro Phe Asp Lys Ala Pro Ile Phe Ala Leu Arg Leu Ala Met Ala Leu 70 75 Ile Thr Giu Cys Ala Phe Leu Asp Asn Asp Ser Ala Leu Gin Ile Lys 90 Gly Met Pro Tyr Lys Ala His Glu Leu Val Gly Glu Ile Asn Pro Leu 100 105 110 Ser Pro Leu Phe Ser Met 115 INFORMATION FOR SEQ ID NO:751: SEQUENCE CHARACTERISTICS: LENGTH: 200 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...200 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:751 Met Ala Val Leu Lys Lys Met Ile Gly Leu Val Ala Val Leu Ser Val 1 5 10 Leu Leu Ala Arg Asp Asn Pro Phe Glu Pro Glu Ile Asn Ser Lys Asn 25 Leu Gin Gly Gly Phe Ser Gly Ile Tyr Asp Asp Tyr Leu Lys Glu Ile 40 His Val Asp Leu Pro Thr Ser Ala Arg Ile Leu Lys Lys Ile Thr Leu 55 Thr Tyr Gin Asp Ile Asp Gly Ser Ile His Ser Lys Val Val Gly Ile 70 75 Asp Lys Ser Ile Asp Trp His Tyr Pro Leu Lys Leu Ser Gln His Thr 90 Leu Asn Gln Asp Ala Phe Glu Lys Arg Tyr Gln Ile Gin Asp Phe Asp 100 105 110 Phe Leu Met Ala Asn Asn Thr Met Ile Leu Arg Ser Pro Tyr Lys Ile 115 120 125 Leu Arg Ser Phe Val Leu Val Asn Pro Tyr Arg Ile Val Leu Asp Thr 130 135 140 Gin Lys Gly Pro Leu Asp Ile Tyr Gin Asn Met Asp Leu Asn Gin Lys 145 150 155 160 Phe Phe Ser His Ile Lys Val Gl- Thr His Lys Asp Tyr Tyr Arg Ile 165 170 175 \K<Ar 7 c~Y' IPENUS 18 DEC1996 624 Thr Leu Ile Leu Asp Gly Lys Tyr Arg Tyr Leu Leu Glu Glu Lys Asn 180 185 190 Gly Ala Tyr Glu Leu Lys Leu Lys 195 200 INFORMATION FOR SEQ ID NO:752: SEQUENCE CHARACTERISTICS: LENGTH: 79 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...79 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:752 Met Gly Gly Phe Thr Ser Ile Trp His Trp Val Ile Val Leu Leu Val 1 5 10 Ile Val Leu Leu Phe Gly Ala Lys Lys Ile Pro Glu Leu Ala Lys Gly 25 Leu Gly Ser Gly Ile Lys Asn Phe Lys Lys Ala Val Lys Asp Asp Glu 40 Glu Glu Ala Lys Asn Glu Leu Lys Thr Leu Asp Ala Gln Ala Thr Gin 55 Thr Lys Val His Glu Thr Ser Glu Ile Lys Ser Lys Gln Glu Ser 70 INFORMATION FOR SEQ ID NO:753: SEQUENCE
CHARACTERISTICS:
LENGTH: 97 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...97 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:753 Leu Thr Thr Lys Ala Cys Trp Leu Leu Arg Val Cys Cys Tyr Arg Ser 1 5 10 Leu Asn Ile Thr Ile Lys Asp Arg Thr Met Lys Thr Asn Gly His Phe 25 Lys Asp Phe Ala Trp Lys Lys Cys Phe Leu Gly Ala Ser Val Val Ala 40 Leu Leu Val Gly Cys Ser Pro His Ile Ile Glu Thr Asn Glu Val Ala PCT/US 96/09122 }.j-L 625 55 Leu Lys Leu Asn Tyr His Pro Ala Ser Glu Lys Val Gin Ala Leu Asp 70 75 Glu Lys Ile Leu Leu Leu Arg Pro Ala Phe Gln Tyr Ser Unk Asn Ile 90 Cys INFORMATION FOR SEQ ID NO:753: SEQUENCE CHARACTERISTICS: LENGTH: 97 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...97 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:753 Leu Thr Thr Lys Ala Cys Trp Leu Leu Arg Val Cys Cys Tyr Arg Ser 1 5 10 Leu Asn Ile Thr Ile Lys Asp Arg Thr Met Lys Thr Asn Gly His Phe 25 Lys Asp Phe Ala Trp Lys Lys Cys Phe Leu Gly Ala Ser Val Val Ala 40 Leu Leu Val Gly Cys Ser Pro His Ile Ile Glu Thr Asn Glu Val Ala 55 Leu Lys Leu Asn Tyr His Pro Ala Ser Glu Lys Val Gln Ala Leu Asp 70 75 Glu Lys Ile Leu Leu Leu Arg Pro Ala Phe Gln Tyr Ser Unk Asn Ile 90 Cys INFORMATION FOR SEQ ID NO:754: SEQUENCE CHARACTERISTICS: LENGTH: 145 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...145 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:754 PT/US 96/091 2 pENUSi c 9 626 Leu Ser Glu'Trp Gin Thr Phe Cys Leu Lys Asp Leu Gly Lys Ile Val 1 5 10 Gly Gly Ala Thr Pro Pro Thr Asn Asn Pro Lys Asn Tyr Gly Asn Lys 25 Ile Ala Trp Ile Thr Pro Lys Asp Leu Ser Thr Leu Gln Gly Arg Tyr 40 Ile Lys Lys Gly Ser Arg Ser Ile Ser Arg Leu Gly Phe Lys Ser Cys 55 Ser Cys Val Leu Leu Pro Lys His Ala Ile Leu Phe Ser Ser Arg Ala 70 75 Pro Ile Gly Tyr Val Ala Ile Ala Glu Lys Arg Leu Cys Thr Asn Gin 90 Gly Phe Lys Ser Ile Ile Pro Asn Lys Lys Ile Tyr Phe Glu Phe Leu 100 105 110 Tyr Tyr Leu Leu Lys Tyr Tyr Lys Asp Asn Ile Ser Asn Ile Gly Gly 115 120 125 Gly Thr Thr Phe Lys Glu Val Ser Gly Ala Thr Leu Gly Ser Ile Pro 130 135 140 Ser 145 INFORMATION FOR SEQ ID NO:754: SEQUENCE CHARACTERISTICS: LENGTH: 145 amino acids TYPE: amino acid TOPOLOGY: linear.
(ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature- LOCATION 1...145 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:754 Leu Ser Giu Trp Gin Thr Phe Cys Leu Lys Asp Leu Gly Lys Ile Val 1 5 10 Gly Gly Ala Thr Pro Pro Thr Asn Asn Pro Lys Asn Tyr Gly Asn Lys 25 Ile Ala Trp Ile Thr Pro Lys Asp Leu Ser Thr Leu Gin Gly Arg Tyr 40 Ile Lys Lys Gly Ser Arg Ser Ile Ser Arg Leu Gly Phe Lys Ser Cys 55 Ser Cys Val Leu Leu Pro Lys His Ala Ile Leu Phe Ser Ser Arg Ala 70 75 Pro Ile Gly Tyr Val Ala Ile Ala Glu Lys Arg Leu Cys Thr Asn Gin 90 Gly Phe Lys Ser Ile Ile Pro Asn Lys Lys Ile Tyr Phe Glu Phe Leu 100 105 110 Tyr Tyr Leu Leu Lys Tyr Tyr Lys Asp Asn Ile Ser Asn Ile Gly Gly 115 120 125 Gly Thr Thr Phe Lys Glu Val Ser Gly Ala Thr Leu Gly Ser Ile Pro 130 135 140 Ser 145 INFORMATION FOR SEQ ID NO:755: PCTUS 96/09122 IPEA/US ibu Ju W6 627 SEQUENCE CHARACTERISTICS: LENGTH: 206 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...206 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:755 Val Arg Leu Asn Ala Ala Val Val Val Asp Gly Lys Tyr Lys Ile Ala 1 5 10 Leu Glu Asp Gly Ala Asn Ala Leu Glu Tyr Glu Pro Leu Ser Asp Glu 25 Unk Unk Lys Lys Ile Asn Unk Leu Val Lys Gln Ala Ile Gly Asp Asn 40 Gln Asn Arg Gly Asp Asp Val Ala Val Ser Asn Phe Glu Phe Asn Pro 55 Met Val Pro Met Ile Asp Asn Ala Thr Leu Ser Glu Lys Ile Ile Tyr 70 75 Lys Thr Gln Lys Ile Leu Gly Leu Phe Met Phe Leu Ile Lys Val Tyr 90 Leu Val Phe Ile Val Leu Phe Ile Phe Tyr Lys Lys Val Ile Val Pro 100 105 110 Phe Ser Glu Arg Met Leu Glu Val Val Pro Asp Glu Asp Lys Glu Val 115 120 125 Lys Ser Met Phe Glu Glu Met Asn Glu Glu Glu Asp Glu Leu Asn Lys 130 135 140 Leu Gly Asp Leu Arg Lys Lys Val Glu Asp Gln Leu Gly Leu Asn Ala 145 150 155 160 Ser Phe Ser Glu Glu Glu Val Arg Tyr Glu Ile Ile Leu Glu Lys Ile 165 170 175 Arg Gly Thr Leu Lys Giu Arg Pro Asp Glu Ile Ala Thr Leu Phe Lys 180 185 190 Leu Leu Ile Lys Asp Glu Ile Ser Ser Asp Ser Ala Lys Gly 195 200 205 INFORMATION FOR SEQ ID NO:756: SEQUENCE CHARACTERISTICS: LENGTH: 98 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...98 rT,) T1 /091 2 IPEANUS 1 b U i9S6 628 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:75 6 Val Cys Phe lie Leu Pro Phe Cys Leu Gly Val Leu Gly Thr Gin Ile 1 5 10 Phe Lys Gin Glu Thr Pro Arg Gin Leu Pro Ile Val Val Val Asp Leu 25 Asp Lys Thr Thr Thr Ser His Gin Val Ala Phe Glu Leu Gly Ala Thr 40 Ser Ala Val Glu Ile Lys Tyr Gin Val Thr Ser Leu Ser Glu Ala Lys 55 Arg Phe Leu Asn Ser Ala Glu Val Tyr Gly Ala Leu Ile Leu Pro Lys 70 75 Asp Leu Glu Arg Lys Ile Lys Met Gly Arg Lys Val Unk Phe Ala Leu 90 Leu Leu INFORMATION FOR SEQ ID NO:75 7 SEQUENCE
CHARACTERISTICS:
LENGTH: 197 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...197 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:75 7 Met Lys Gly Leu Trp Leu Val Ile Ser Leu Val Phe Val Gly Phe Leu 1 5 10 Trp Ala Asn Glu Ser Tyr Val Phe Asn Asn Ser Lys Gly Arg Leu Thr 25 Glu Lys Ser Val Ala Phe Ile Glu Gly Val Ser Lys Glu Leu Tyr Leu 40 Lys Thr Gly Val Arg Phe Ala Ile Asp Met Thr Asp Phe Glu Lys Asn 55 Pro Ile Ala Leu Ala Asn Lys Lys Glu Arg Gln Ser Tyr Gin Glu Gly 70 75 Phe Leu Lys Gin Leu Lys Pro Pro Phe Val Val Phe Phe Phe Tyr His 90 Asp Ala Gin Lys Ile Glu Leu Val Ala Asn Pro Lys Asp Leu Leu Asp 100 105 110 Thr Asp Lys Ile Phe Phe Glu Lys Ile Ala Pro Leu Leu Pro Thr Asn 115 120 125 Ala Lys Glu Tyr Thr Pro Gin Arg Ile Ser Ala Met Leu Ile Asn Gly 130 135 140 Tyr Ser Val Ala Val Asp Ala Leu Ala Glu Lys Tyr His Val Asn Ile 145 150 155 160 Thr Gin Asn Phe Ser Ala Pro Lys Gly Val Thr Phe Val Lys Val Val 165 170 175 Ile Tyr Ile Leu Leu Leu Thr Leu Leu Gly Ala Phe Leu Gly Leu Tyr 180 185 190 Phe Phe Lys Lys Ser 195 PC- /09i 2Z IPEA/US 18 :.:1996 629 INFORMATION FOR SEQ ID NO:758: SEQUENCE CHARACTERISTICS: LENGTH: 148 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...148 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:758 Leu Val Gln Ile Val Val Val Phe Tyr Gly Leu Pro Ala Leu Gly Val 1 5 10 Tyr Met Asp Pro Ile Pro Ala Gly Ile Ile Ala Phe Ser Phe Asn Val 25 Gly Ala Tyr Ala Ser Glu Thr Leu Arg Ala Ser Phe Leu Ser Val Pro 40 Lys Asp Gln Trp Asp Ser Ser Leu Ser Leu Gly Leu Asn Tyr Leu Gin 55 Thr Phe Trp His Val Ile Phe Phe Gin Ala Leu Lys Val Ala Thr Pro 70 75 Ser Leu Ser Asn Thr Phe Ile Ser Leu Phe Lys Glu Thr Ser Leu Ala 90 Ser Val Val Thr Ile Ala Glu Unk Phe Arg Ile Ala Gln Gln Lys Unk 100 105 110 Asn Val Ser Tyr Asp Phe Unk Pro Ile Tyr Leu Glu Unk Ala Leu Ile 115 120 125 Tyr Trp Leu Phe Cys Leu Val Leu Glu Val Ile Gln Lys Arg Val Glu 130 135 140 Lys Ile Leu Asn 145 INFORMATION FOR SEQ ID NO:758: SEQUENCE CHARACTERISTICS: LENGTH: 148 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...148 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:758 Leu Val Gln Ile Val Val Val Phe Tyr Gly Leu Pro Ala Leu Gly Val 1 5 10 PC7/'U 9./09122 IPEA/US i u z 6 630 Tyr Met Asp Pro Ile Pro Ala Gly Ile Ile Ala Phe Ser Phe Asn Val 20 25 Gly Ala Tyr Ala Ser Glu Thr Leu Arg Ala Ser Phe Leu Ser Val Pro 40 Lys Asp Gln Trp Asp Ser Ser Leu Ser Leu Gly Leu Asn Tyr Leu Gin 55 Thr Phe Trp His Val Ile Phe Phe Gln Ala Leu Lys Val Ala Thr Pro 70 75 Ser Leu Ser Asn Thr Phe Ile Ser Leu Phe Lys Glu Thr Ser Leu Ala 90 Ser Val Val Thr Ile Ala Glu Unk Phe Arg Ile Ala Gln Gln Lys Unk 100 105 110 Asn Val Ser Tyr Asp Phe Unk Pro Ile Tyr Leu Glu Unk Ala Leu Ile 115 120 125 Tyr Trp Leu Phe Cys Leu Val Leu Glu Val Ile Gln Lys Arg Val Glu 130 135 140 Lys Ile Leu Asn 145 INFORMATION FOR SEQ ID NO:759: SEQUENCE
CHARACTERISTICS:
LENGTH: 68 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...68 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:759 Met Cys Ser Lys Lys Ile Arg Asn Leu Ile Leu Cys Phe Gly Phe Ile 1 5 10 Leu Ser Leu Cys Ala Glu Glu Asn Ile Thr Lys Glu Asn Met Thr Glu 25 Thr Asn Thr Thr Glu Glu Asn Thr Pro Lys Asp Ala Pro Ile Leu Leu 40 Glu Glu Lys Arg Ala Gln Thr Leu Glu Leu Lys Glu Glu Asn Glu Val 55 Ala Lys Lys Ile INFORMATION FOR SEQ ID NO:760: SEQUENCE
CHARACTERISTICS:
LENGTH: 134 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori PCEU i6/091 2 2 IPEA/US 1 8 D C 1996.
631 (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...134 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:760 Val Val Ala Asp Glu Val Arg Asn Leu Ala Gly Arg Thr Gin 1 Leu Asp Ser Asn Ala Val Asn Val Ala Val Asp Leu Lys Glu Ile Asn 130 Glu Ser Met Ser Ser Lys Ala 115 Leu Ile Ser Ser Ser Gly Val 100 Thr Phe 5 Asn Gin Lys Val His Ala His Lys 10 Val Ser Thr Asn Met 90 Ala Thr Ile Gin Tyr Gin 75 Val Asp Met Val Lys Glu Ser Ser Ser Asn Gin Met Lys Met Asp Ser Leu 125 Lys Ile Arg Ser Asp Ala Ile Lys Ser Asn Leu Ser Tyr Glu Leu Gin INFORMATION FOR SEQ ID NO:760: SEQUENCE CHARACTERISTICS: LENGTH: 134 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...134 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:760 Val Val Ala Asp Glu Val Arg Asn Leu Ala Gly 1 5 10 Leu Ala Glu Ile Asn Ser Thr Ile Met Val Ile 25 Asp Val Ser Ser Gln Met Asn Leu Asn Ser Gin 40 Ser Asp Met Ser Lys Ser Val Gln Glu Thr Tyr 55 Asn Leu Ser Ser Val Val Leu Asp Ser Asn Gin 70 75 Ala Lys Ser Gly His Gln Ile Glu Ala Met Val 90 Val Glu Lys Val Ala Ser Lys Thr Leu Ala Asp 100 105 Asn Ile Ala Thr His Val Ser Gly Thr Thr Met 115 120 Val Asn Leu Phe Lys Thr 130 Arg Thr Val Gin Lys Met Glu Lys Ser Met Ser Asp Ser Ser Asn Leu 125 Gin Lys Ser Glu Ile Asn Glu Arg Leu Met Ser Ser Asp Asp Tyr Phe Ala Glu Asp Ile Leu 110 Unk Lys Gin f. 96/09122 IPENUS i8 D C1996 INFORMATION FOR SEQ ID NO:761: SEQUENCE CHARACTERISTICS: LENGTH: 93 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...93 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:761 Val Leu Lys Thr Leu Ser Ile Arg Leu Val Ile 1 5 10 Leu Ala Thr Asn Ala Cys Ser Gly Val Gln Lys 25 His Arg Tyr Ala Ile Asn Phe His Arg Ser Thr 40 Lys Gln Ile Ala Leu Leu Lys Glu Lys Gly Ile Lys Lys Leu Leu Asp Tyr Phe Gly Ser Phe Glu 70 75 Ser Asp Gln Glu Lys Asn Ala Val Leu Lys Lys Leu Arg Leu Glu Ile Lys Asn Cys Ser Asp Glu Ser Lys Asn Met Ala Ser Val Glu Lys Ala INFORMATION FOR SEQ ID NO:762: SEQUENCE CHARACTERISTICS: LENGTH: 73 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...73 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:762 Val Gly Ile Ile Arg Gly Ile Ile His Arg Pro Glu Leu Ile Leu Leu 1 5 10 Asp Glu Pro Phe Ser Ala Leu Asp Ser Leu Asn Arg Lys Asn Leu Gln 25 Asp Leu Ile Lys Glu Ile His Gln Asn Ser Cys Ala Thr Phe Ile Met 40 Val Thr His Asp Glu Asn Glu Ala Gln Lys Leu Ala Thr Lys Thr Leu 55 \Glu Ile Lys Ala Leu Lys Gln Glu Gin IPENUS 18 D LC01996 INFORMATION FOR SEQ ID NO:763: (i)-SEQUENCE
CHARACTERISTICS:
LENGTH: 268 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION .268 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:763 Val Ile Phe Ile Ala 1 5 Leu Arg Asp Arg Met Thr Aa Asri Asn Ile Asp Arg Ile Pro Ala Pro Giu Phe Ilie Giu Lys Glu Glu Ilie Ala Lys Asn Lys 1H Lys L Arg Giu Asp Asp Arg 145 Ile Ile Ser Val Ser 225 Unk Lys [is ~0 ~eu ~rg ksp -ys Phe 130 Met Val Giu Leu
LYS
210 Gi1; Asr Th2 Ala Ile Gin Asn Lys 115 Cys Val Asn Ala Gly 195 Val LThi Ai Al~ Leu Ile Ile Pro 100 Gly Val1 Phe Giy Val 180 Asp Leu Asj Ar~ 264 Lys Pro 1 Glu Lys 70 Ala Thr His Lys Gly Asn Ser Ile Glu Ile 150 Leu Ala 165 Lys Ile Val Met Leu Asp Ala Glu 230 Asp Leu 245 g Ala Leu 0 er L'yr Ile Lays Glu Thr 135 Glu Thr Met G ly Giu 120 Pro Ser Val 25 Tyr Leu Vai Asp Arg Giu Arg Lys 90 Arg Thr 105 Asn Giu Asp Asn Ser Ile Ile Ala 75 Ala Lys Lys Leu Ser Pro Sen Gly Ala Lys Ang Lys 140 Glu T'yr Gin His Val Leu Sen Gly 125 Glu Asn Thr Glu Glu Arg Lys GlU 110 Glu Tyr Lys Pro Ser Leu Glu Cys Leu Asp Leu Tyr Leu Asp Lys Ser Lys Leu Giu Ile Gly 160 Unk Pro Ile Asp '-iu Trp Ang Lys Asn 215 Asn His Gly Thr Gly Glu 200 Giu Unk Leu Ser Pro Lys 185 Ser Thr Lys His Leu 265 Val1 170 Gly Ala Leu Lys Val 250 Trp Gly Glu Ile Lys Lys 235 Pro Arg Gly Leu.
Ile Val1 220 Lys Lys Ala Asp Lys Ala 205 Pro Val Gly Val Leu 190 Phe Lys Leu Leu 175 Thr Ser Ile Lys Ang 255 Gly Val Pro Val1 240 Leu INFORMATION FOR SEQ ID NO:764: SEQUENCE
CHARACTERISTICS:
LENGTH: 273 amino acids TYPE: amino acid TOPOLOGY: linear PCT/US 9 6 /091 2 2 IPEA/US 18 Dau 996 634 (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...273 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:764 Met 1 Leu Asn Gly Asn Ala Phe Arg Val Gly 145 Gly Ala Val Thr Asn 225 Leu Tyr Phe Glu Phe Met Lys Lys Phe Val Ala Leu Gly Ser Tyr Asp Lys Asn Phe Val Tyr 130 Ser Ile Ala Cys Ser 210 Ile Ile His Ser Gin Cys His Gly Gin Tyr 115 Ala Asp Phe Asn Thr 195 Thr Tyr Asn Leu 5 Ser Leu Leu Gly Thr Gly Asn Pro Ala Leu Phe Lys 100 Gly Leu Pro Asn Leu Leu Gly Gly 165 Tyr Trp 180 Pro Thr Val Ala Lys His Lys Phe 245 Lys Arg 260 Leu Gin Ser Gly 70 Asn Ser Phe Lys Ala 150 Val Lys Tyr Phe Asn 230 Leu Ala Ala Val 55 Gly Gly Leu Asp Ile 135 Asp Ala Glu Cys Gin 215 Gly Ser Glu Arg 40 Val Thr Phe Asp Tyr 120 Gin Ile Ile Gin Asn 200 Val Val Ala Gly 25 Leu Gly Asn Gly Met 105 Gly Leu Ile Gly Ile 185 Pro Trp Glu Gly Leu 265 10 Asp Asn Cys Ile Leu 90 Thr His Asp Asp Gly 170 Ile Asn Leu Phe Pro 250 Gly Ser Pro Asn 75 Asn Ser Ala Met Lys 155 Asn Glu Ala Asn Gly 235 Asn Leu Leu Val Tyr Asn Ile Pro Gly Trp His Val Gly Lys Trp Asp Leu 125 Val Ser 140 Asp Asn Thr Trp Ala Lys Pro Tyr 205 Phe Gly 220.
Val Arg Ala Thr Ser Ile Tyr Leu Ser Tyr Phe 110 Gly Trp Ala Lys Gly 190 Ser Val Val Asn Asn 270 Ala Gly Asn Thr Lys Lys Gly Lys Gly Ser Ser 175 Pro Thr Arg Pro Leu 255 Tyr Val Thr Thr Ala Tyr Lys Phe Gin Val Phe 160 Ser Asp Asn Ala Leu 240 Tyr Thr Asp Tyr Ser Tyr Leu Gly Tyr INFORMATION FOR SEQ ID NO:764: SEQUENCE CHARACTERISTICS: LENGTH: 273 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori IPEUS18 DEC 1996 635 (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...273 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:764 Met Glu Phe Met Lys Lys Phe Val Ala Leu Gly Leu 1 Leu Asn Gly Asn Ala Phe Arg Val Gly 145 Gly Ala Val Thr Asn 225 Leu Tyr Phe 5 Leu Gly Gly Pro Leu Lys Leu Asn Leu Gly 165 Trp Thr Ala His Phe 245 Arg Leu Gin Ser Gly 70 Asn Ser Phe Lys Ala 150 Val Lys Tyr Phe Asn 230 Leu Asp Ala Ala Val Gly Gly Leu Asp Ile 135 Asp Ala Glu Cys Gin 215 Gly Ser Tyr Glu Arg Val Thr Phe Asp Tyr 120 Gin Ile Ile Gin Asn 200 Val Val 1 Ala Ser Gly Leu Gly Asn Gly Met 105 Gly Leu Ile Gly Ile 185 Pro Trp Glu Gly Leu 265 10 Asp Asn Cys Ile Leu 90 Thr His Asp Asp Gly 170 Ile Asn Leu Phe Pro 250 Val Asn Pro Trp Val Lys Asp Val 140 Asp Thr Ala Pro Phe 220 Val Ala Leu Tyr Ile Gly His Gly Trp Leu 125 Ser Asn Trp Lys Tyr 205 Gly Arg Thr Ser Ile Tyr Leu Ser Tyr Phe 110 Gly Trp Ala Lys Gly 190 Ser Val Val 1 Asn Ala Gly Asn Thr Lys Lys Gly Lys Gly Ser Ser 175 Pro Thr Arg Pro Leu 255 Val Thr Thr Ala Tyr Lys Phe Gin Val Phe 160 Ser Asp Asn Ala Leu 240 Tyr Tyr Leu Gly Tyr Asn Tyr Thr 270 INFORMATION FOR SEQ ID NO:765: SEQUENCE CHARACTERISTICS: LENGTH: 133 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...133 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:765 PLi/ 9 /u'i IPEAUS 18 DEC1996 636 Met Asn Tyr Asp Asn Tyr Trp Asp Glu Asp Lys Pro Glu Leu Asn Ile 1 5 10 Thr Pro Leu Val Asp Val Met Leu Val Leu Leu Ala Ile Leu Met Val 25 Thr Thr Pro Thr Leu Thr Tyr Lys Glu Glu Ile Ala Leu Pro Ser Gly 40 Ser Lys Thr Ala Arg Ala Thr Gln Asp Lys Val Ile Glu Ile Arg Met 55 Asp Lys Asp Ala Lys Ile Tyr Ile Asp Ser Gln Thr Tyr Glu Tyr Unk 70 75 Ser Phe Pro Asp Thr Phe Asn Leu Leu Ser Lys Lys Tyr Asp Lys Asp 90 Thr Arg Val Ser Ile Arg Ala Asp Lys Arg Leu Thr Tyr Asp Lys Val 100 105 110 Ile Tyr Leu Leu Lys Thr Ile Lys Glu Ala Gly Phe Leu Lys Val Ser 115 120 125 Leu Ile Thr Ser Pro 130 INFORMATION FOR SEQ ID NO:765: SEQUENCE
CHARACTERISTICS:
LENGTH: 133 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...133 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:765 Met Asn Tyr Asp Asn Tyr Trp Asp Glu Asp Lys Pro Glu Leu Asn Ile 1 5 10 Thr Pro Leu Val Asp Val Met Leu Val Leu Leu Ala Ile Leu Met Val 25 Thr Thr Pro Thr Leu Thr Tyr Lys Glu Glu Ile Ala Leu Pro Ser Gly 40 Ser Lys Thr Ala Arg Ala Thr Gln Asp Lys Val Ile Glu Ile Arg Met 55 Asp Lys Asp Ala Lys Ile Tyr Ile Asp Ser Gln Thr Tyr Glu Tyr Unk 70 75 Ser Phe Pro Asp Thr Phe Asn Leu Leu Ser Lys Lys Tyr Asp Lys Asp 90 Thr Arg Val Ser Ile Arg Ala Asp Lys Arg Leu Thr Tyr Asp Lys Val 100 105 110 Ile Tyr Leu Leu Lys Thr Ile Lys Glu Ala Gly Phe Leu Lys Val Ser 115 120 125 Leu Ile Thr Ser Pro 130 INFORMATION FOR SEQ ID NO:766: SEQUENCE CHARACTERISTICS: LENGTH: 71 amino acids TYPE: amino acid PfT/I' 96/091 2 637 IPEiUS 18 1996 TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...71 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:766 Met Pro Pro Thr Unk Pro Gln Ala Ser Ile Leu Arg Leu Thr Leu Lys 1 5 10 Asn Pro Leu Unk Unk Leu Ser Arg Tyr Ser Leu Cys Leu Leu Lys Lys 25 Thr Arg Leu Gln Thr Thr Ser Asn Ser Ala Pro Lys Ala Cys Leu Ile 40 Ala Gly Leu Leu Lys Lys Ser Lys Pro Phe Ile Leu Asn Thr Leu Lys 55 Ile Arg Ser Leu Leu Lys Pro INFORMATION FOR SEQ ID NO:766: SEQUENCE CHARACTERISTICS: LENGTH: 71 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...71 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:766 Met Pro Pro Thr Unk Pro Gln Ala Ser Ile Leu Arg Leu Thr Leu Lys 1 5 10 Asn Pro Leu Unk Unk Leu Ser Arg Tyr Ser Leu Cys Leu Leu Lys Lys 25 Thr Arg Leu Gin Thr Thr Ser Asn Ser Ala Pro Lys Ala Cys Leu Ile 40 Ala Gly Leu Leu Lys Lys Ser Lys Pro Phe Ile Leu Asn Thr Leu Lys 55 Ile Arg Ser Leu Leu Lys Pro INFORMATION FOR SEQ ID NO:767: SEQUENCE CHARACTERISTICS: LENGTH: 147 amino acids TYPE: amino acid S(D) TOPOLOGY: linear PCT/US 9 6 09122 IPEA/US 18 DEC1996 638 (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi)-ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION 1...147 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:767 Met Gly Cys Ser Phe Ile Phe Lys Lys Val Arg Val Tyr Ser Lys Met 1 5 10 Leu Val Ala Leu Gly Leu Ser Ser Val Leu Ile Gly Cys Ala Met Asn 25 Pro Ser Ala Glu Thr Lys Lys Pro Asn Asp Ala Lys Asn Gln Gln Pro 40 Val Gln Thr His Glu Arg Met Thr Thr Ser Ser Glu His Val Thr Pro 55 Leu Asp Phe Asn Tyr Pro Val His Ile Val Gln Ala Pro Gln Asn His 70 75 His Val Val Gly Ile Leu Met Pro Arg Ile Gln Val Ser Asp Asn Leu 90 Lys Pro Tyr Ile Asp Lys Phe Gln Asp Ala Leu Ile Asn Gln Ile Gin 100 105 110 Thr Ile Phe Glu Lys Arg Gly Tyr Gin Val Leu Arg Phe Gin Asp Glu 115 120 125 Lys Ala Leu Asn Val Gln Asp Lys Lys Lys Ile Phe Ser Val Leu Asp 130 135 140 Leu Lys Gly 145 INFORMATION FOR SEQ ID NO:768: SEQUENCE CHARACTERISTICS: LENGTH: 144 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...144 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:768 Met Asp Arg Lys Leu Leu Arg Leu Tyr Gln Pro Leu Asn Ala Tyr Ser 1 5 10 Tyr Asn Ser Asp Ser Leu Phe Leu Tyr Asp Phe Ser Arg Pro Phe Ile 25 Lys Asn Ser Gly Ala Ile Leu Asp Ile Gly Ser Gly Cys Gly Val Leu 40 Gly Leu Leu Cys Ala Arg Asp Asn Pro Leu Ala Ser Val His Leu Val 55 Glu Lys Asp Ser Lys Met Ala Phe Cys Ser Gin Lys Asn Ala Leu Lys PCT/US 9 6 091 2.2 IPEA/US 18 DEC 1996 Phe Pro Gly Leu 70 75 Asn Ala Gin Val Phe GIu Ser Asp Phe Leu Asp Phe Asn Pro 90 Leu Tyr Asp Ala Ile Val Cys Asn Pro Pro Phe Tyr Ala Leu 100 105 110 Ile Lys Ser Gin Ile Lys Gly His Ala Arg His Gin Ser Glu 115 120 125 Phe Ala Ser Leu Val Ala Lys Val Lys Lys Cys Leu Lys Pro 135 140 INFORMATION FOR SEQ ID NO:769: SEQUENCE CHARACTERISTICS: LENGTH: 47 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...47 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:769 Met Leu Ser Ala Leu Val Met Leu Pro Phe Met Glu Val Phe Tyr Tyr 1 5 10 Phe Asn Phe Pro Leu Trp Leu Asn Leu Phe Leu Gly Gin Thr Ile Gly 25 Ala Val Ile Phe Phe Lys Leu Asp Lys Leu Ile Phe Ser Lys Lys 40 INFORMATION FOR SEQ ID NO:770.: SEQUENCE CHARACTERISTICS: LENGTH: 129 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...129 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:770 Met Asn Thr Ile Ile Arg Tyr Ala Ser Leu Trp Gly Leu Cys Ile Thr 1 5 10 Leu Thr Leu Ala Gin Thr Pro Ser Lys Thr Pro Asp Glu Ile Lys Gin 25 Ile Leu Asn Asn Tyr Ser His Lys Asn Leu Lys Leu Ile Asp Unk Pro 40 (K PR PCT/US 9 6 0912 i EA/US 18 DEC 1996 640 Thr Ser Ser 'Leu Unk Ala Thr Pro Gly Phe Unk Pro Ser Pro Lys Glu 55 Thr Ala Thr Thr Ile Asn Gln Glu Ile Ala Lys Tyr His Glu Lys Ser 70 75 Asp Lys Ala Ala Leu Gly Leu Tyr Glu Leu Leu Lys Gly Ala Thr Thr 90 Asn Leu Ser Leu Gln Ala Gln Glu Leu Ser Val Lys Gln Ala Met Glu 100 105 110 Glu Pro His His Arg Gln Ser Asp Val Phe Ala Tyr Phe Glu Arg Glu 115 120 125 Leu INFORMATION FOR SEQ ID NO:771: SEQUENCE CHARACTERISTICS: LENGTH: 242 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...242 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:771 Met Val Leu Phe Leu Ser Ile Phe Lys Lys Ser Phe Asn Asp Phe Leu 1 5 10 Ser Ala Arg Met Leu Leu Ile Asn Leu Gly Pro Ile Leu Leu Ser Leu 25 Ala Phe Phe Gly Ala Ile Phe Tyr Tyr Asn Gly Gly Ser Ile Val Asn 40 Tyr Cys Gln Thr Leu Leu Pro Gln Ser Leu Asn Asp Tyr Ala His Ser 55 Gin Gly Phe Phe Ala Gly Val Phe Ala Trp Val Phe Lys Ala Leu Val 70 75 Tyr Phe Leu Ile Phe Trp Ile Val Ile Leu Leu Ser Leu Val Ile Asn 90 Ile Phe Ala Ser Ile Phe Tyr Thr Pro Leu Val Val Ser Tyr Leu His 100 105 110 Gin Lys Tyr Tyr Pro His Val Val Leu Glu Glu Phe Gly Ser Ile Leu 115 120 125 Phe Ser Ile Lys Tyr Phe Leu Lys Ser Leu Thr Phe Met Leu Leu Phe 130 135 140 Leu Ala Val Leu Thr Pro Leu Tyr Phe Ile Pro Phe Ile Gly Val Phe 145 150 155 160 Gly Val Phe Phe Ser Ile Val Pro His Phe His Phe Phe Lys Asn Thr 165 170 175 Met Ser Leu Asp Ile Ala Ser Met Ile Phe Asn His Gln Ser Tyr Gin 180 185 190 Asn Leu Leu Lys Gln His Arg Leu Lys His Tyr Arg Phe Ser Phe Phe 195 200 205 Cys Tyr Leu Phe Ser Leu Ile Pro Phe Phe Asn Phe Phe Ala Thr Leu 210 215 220 Leu Gln Thr Leu Lys Leu Thr His Tyr Ile Phe Ile Phe Lys Glu Lys 225 230 235 240 Glu Cys PCT/US 96109122.
IPEA/US 18 DEC1996 641 INFORMATION FOR SEQ ID NO:772: (i)-SEQUENCE CHARACTERISTICS: LENGTH: 97 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...97 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:772 Met Gin Tyr Ala Asn Ala Tyr Gin Ala Tyr Gin His Asn Arg Val Ser 1 5 10 Val Glu Ser Pro Ala Lys Leu Ile Glu Met Leu Tyr Glu Gly Ile Leu 25 Arg Phe Ser Ser Gln Ala Lys Arg Cys Ile Glu Asn Glu Asp Ile Glu 40 Lys Lys Ile Tyr Tyr Ile Asn Arg Val Thr Asp Ile Phe Thr Glu Leu 55 Leu Asn Ile Leu Asp Tyr Glu Lys Gly Gly Unk Val Ala Val Tyr Leu 70 75 Thr Gly Leu Tyr Thr His Gln Ile Lys Val Leu Thr Gin Ala Asn Val 90 Glu INFORMATION FOR SEQ ID NO:773: SEQUENCE CHARACTERISTICS: LENGTH: 143 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...143 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:773 Met Met Phe Asp Asn Thr Leu Ile Asn Leu Phe Glu Thr Ala Pro Leu 1 5 10 Leu Thr Ser Leu Leu Ala Gly Ile Leu Thr Phe Leu Ser Pro Cys Val 25 sLeu Pro Leu Ile Pro Ala Tyr Met Ser Tyr Ile Ser Gln Ile Ser Leu 40 m FT 3/09122 IPEA/US 18 U L 1996 642 Glu Asp Ile Lys Asp Gly Lys Ala Lys Arg Val Ser Val Phe Leu Lys 55 Ser Leu Met Phe Val Val Gly Phe Ser Leu Val Phe Leu Gly Val Gly 70 75 Met Ser Met Ala Lys Leu Ile His Ser Phe Ser Phe Ser Trp Val Asn 90 Tyr Ile -Ala Gly Gly Ile Val Ile Leu Phe Gly Leu His Phe Leu Gly 100 105 110 Val Phe Arg Phe Ala Phe Leu Tyr Lys Thr Gln Ser Val Gly Leu Ala 115 120 125 Ser Lys Ser Asn Ser Met Gln Arg Phe Thr Pro Phe Phe Leu Ala 130 135 1 140 INFORMATION FOR SEQ ID NO:774: SEQUENCE CHARACTERISTICS: LENGTH: 217 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...217 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:774 Met Pro Val Ile Arg Val Leu Val Met Leu Ala Thr Met Met Met Lys 1 5 10 Leu Val Lys Thr Ala Lys Glu Lys Lys Val Phe Lys Asn Val Gly Ile 25 Ser Ile Met Gly Ile Ala Phe Trp Glu Ala Ile Lys Asp Ser Ile Lys 40 Lys Gln Ile Lys Lys Ser Asp Trp Ile Cys Gly Asn Val Lys Thr Ala 55 Asp Asp Tyr Leu Lys Thr His Pro Asn Ser Trp Phe Asn Ser Ala Ile 70 75 Gly Val.Thr Ala Ile Thr Ala Met Leu Met Asn Val Cys Phe Ala Asp 90 Asp Gln Ser Lys Lys Glu Val Ala Gln Ala Gln Lys Glu Ala Glu Asn.
100 105 110 Ala Arg Asp Arg Ala Asn Lys Ser Gly Ile Glu Leu Glu Gln Glu Glu 115 120 125 Gin Lys Thr Glu Gln Glu Lys Gln Lys Thr Glu Gln Glu Lys Gin Lys 130 135 140 Thr Glu Gln Glu Lys Gln Lys Thr Glu Gln Glu Lys Gln Lys Thr Glu 145 150 155 160 Gln Glu Lys Gln Lys Thr Ser Asn Ile Glu Thr Asn Asn Gln Ile Lys 165 170 175 Val Glu Gln Glu Gln Gln Lys Thr Glu Gln Glu Lys Gln Lys Thr Asn 180 185 190 Asn Thr Gln Lys Asp Leu Val Asn Lys Ala Glu Gln Asn Cys Gln Glu 195 200 205 Asn His Asn Gln Phe Phe Ile Lys Asn 210 215 INFORMATION FOR SEQ ID NO:774: 1* PCT. 0912 2 IPEA/MJS 18 D Ci996 643 SEQUENCE CHARACTERISTICS: LENGTH: 217 amino acids TYPE: amino acid TOPOLOGY: linear MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...217 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:774 Met Pro Val Ile Arg Val Leu Val Met Leu Ala Thr Met Met Met Lys 1 5 10 Leu Val Lys Thr Ala Lys Glu Lys Lys Val Phe Lys Asn Val Gly Ile 25 Ser Ile Met Gly Ile Ala Phe Trp Glu Ala Ile Lys Asp Ser Ile Lys 40 Lys Gln Ile Lys Lys Ser Asp Trp Ile Cys Gly Asn Val Lys Thr Ala 55 Asp Asp Tyr Leu Lys Thr His Pro Asn Ser Trp Phe Asn Ser Ala Ile 70 75 Gly Val Thr Ala Ile Thr Ala Met Leu Met Asn Val Cys Phe Ala Asp 90 Asp Gln Ser Lys Lys Glu Val Ala Gln Ala Gln Lys Glu Ala Glu Asn 100 105 110 Ala Arg Asp Arg Ala Asn Lys Ser Gly Ile Glu Leu Glu Gln Glu Glu 115 120 125 Gin Lys Thr Glu Gln Glu Lys Gln Lys Thr Glu Gin Glu Lys Gln Lys 130 135 140 Thr Glu Gln Glu Lys Gln Lys Thr Glu Gln Glu Lys Gln Lys Thr Glu 145 150 155 160 Gin Glu Lys Gln Lys Thr Ser Asn Ile Glu Thr Asn Asn Gln Ile Lys 165 170 175 Val Glu Gln Glu Gln Gln Lys Thr Glu Gln Glu Lys Gln Lys Thr Asn 180 185 190 Asn Thr Gln Lys Asp Leu Val Asn Lys Ala Glu Gin Asn Cys Gln Glu 195 200 205 Asn His Asn Gin Phe Phe Ile Lys Asn 210 215 INFORMATION FOR SEQ ID NO:775: SEQUENCE CHARACTERISTICS: LENGTH: 84 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature PCT/US 96/09122 IPEyUS i8 DEC1996 Val 1 Arg Phe His Asp Leu LOCATION 1...84 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:775 Leu Val Val Gly Lys Pro Asn Glu Ser Tyr Ala Asp Thr His 5 10 Ile-Glu His Phe Ile Lys Leu Val Asp Phe Lys Gly Glu Ile 25 Ile Asn Glu Asp Asn Ser Ser Val Glu Ala Tyr Glu Asn Leu 40 Leu Gly Lys Lys Asn Lys Arg Ile Ala Thr Lys Asp Gly Arg 55 Ser Leu Ser Ala Cys Arg Ile Leu Glu Arg Tyr Cys Gin Gin 70 75 Lys Lys Gly Ala Val Glu Leu Val INFORMATION FOR SEQ ID NO:776: SEQUENCE CHARACTERISTICS: LENGTH: 75 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...75 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:776 Met Val Ile Ser Gly His Phe Thr Thr Tyr Ser Tyr Ile Glu Pro Phe 1 5 10 Ile Ile Gln Ile Ser Gln Phe Ser Pro Asp Ile Thr Thr Leu Met Leu 25 Phe Val Phe Gly Leu Ala Gly Val Val Gly Ser Phe Leu Phe Gly Arg 40 Leu Tyr Ala Lys Asn Ser Arg Lys Phe Ile Ala Phe Ala Met Val Leu 55 Val Ile Cys Pro Gln Pro Leu Ala Phe Cys Val 70 INFORMATION FOR SEQ ID NO:776: SEQUENCE CHARACTERISTICS: LENGTH: 75 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: t^ PGT/US 9 6 09 IPL US i ULG1996 645 NAME/KEY: misc_feature LOCATION 1...75 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:776 Met Val Ile Ser Gly His Phe Thr Thr Tyr Ser Tyr Ile Glu Pro Phe 1 5 10 Ile Ile Gln Ile Ser Gln Phe Ser Pro Asp Ile Thr Thr Leu Met Leu 25 Phe Val Phe Gly Leu Ala Gly Val Val Gly Ser Phe Leu Phe Gly Arg 40 Leu Tyr Ala Lys Asn Ser Arg Lys Phe Ile Ala Phe Ala Met Val Leu 55 Val Ile Cys Pro Gln Pro Leu Ala Phe Cys Val 70 INFORMATION FOR SEQ ID NO:777: SEQUENCE CHARACTERISTICS: LENGTH: 155 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...155 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:777 Met Arg Ile Leu Ile Leu Lys Asn Lys Pro Pro Thr Leu Arg Ser Lys 1 5 10 Ala Leu Thr Arg Ser Trp Gly Ile Asn Phe Ser Leu Lys Asn Thr Leu 25 Ala Tyr Ala Phe Met Gly Phe Phe Asp Tyr Ala His Ala Asn Ser Ile 40 Lys Leu Lys Asn Pro Asn Tyr Asn Ser Glu Ala Ala Gln Val Ala Ser 55 Gin Ile Leu Gly Lys Gln Glu Ile Asn Arg Leu Thr Asn Ile Ala Asp 70 75 Pro Arg Thr Phe Glu Pro Asn Met Leu Thr Tyr Gly Gly Ala Met Asp 90 Val Met Val Asn Val Ile Asn Asn Gly Ile Met Ser Leu Gly Ala Phe 100 105 110 Gly Gly Ile Gln Leu Ala Gly Asn Ser Trp Leu Met Ala Unk Pro Ser 115 120 125 Phe Glu Gly Ile Leu Gly Glu Gin Ala Leu Val Ser Arg Lys Pro Leu 130 135 140 Leu Ser Asn Phe Tyr Ser Met Trp Gly Leu Ala 145 150 155 INFORMATION FOR SEQ ID NO:778: SEQUENCE CHARACTERISTICS: LENGTH: 192 amino acids TYPE: amino acid TOPOLOGY: linear PGT/US 9 6/09122 iW& US ib 1996 646 (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...192 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:778 Met Lvs Ser Thr Arg Ile Gly Ser Lys Ile Val Met o IK 1 Val Val Ala Met Ile Asn Arg Thr Ile 145 Tyr Ile Val Ile Glu Ser Gin Leu Gly Ala Asn Asp Pro His Met Ile 115 Ala Leu 130 Thr Arg Unk Unk Unk Unk Val Val Val Asn Thr Val 100 Thr Asn Ser Unk Leu 180 5 lie Leu Ser Thr Leu Leu Ala Glu Unk Ile 165 Asn Ser Gin Phe Leu 70 Lys Leu Met Asn Pro 150 Thr Phe Ala Val Ser Gin 40 Lys Ile 55 Glu Arg Arg Arg Val Ser Asn Met 120 Met Thr 135 Tyr Tyr Leu Pro Unk Leu 10 Met Gly 25 Ala Thr Gin Gly Phe Leu Met Leu 90 Ala Ile 105 Asp Ser Unk Pro Lys Glu Leu Unk 170 Asn Ile 185 Val Glu Ile Ser 75 Ser Tyr Lys Ile Val 155 Unk Ile Leu Met Asp Glu Thr Ile His 140 Asn Lys Met Val Ile Ser Leu Gin Lys Arg Glu Asn Phe Leu Asn Asn 110 Ala Tyr 125 Ser Leu Unk Unk Asn Unk Cys Tyr Lys Ile Gly Leu Asn Pro Lys Lys Asn Ala Lys Lys Phe Ala Ala Glu Asn Ser Ile 160 Unk 175 Asp Unk Phe Leu Tyr Unk 190 INFORMATION FOR SEQ ID NO:778: SEQUENCE CHARACTERISTICS: LENGTH: 192 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...192 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:778 Met Lys Ser Thr Arg Ile Gly Ser Lys Ile Val Met Met Val Cys Ala 1 5 10 Val Val Ile Val Ile Ser Ala Val Met Gly Val Ile Ile Ser Tyr Lys 25 Val Glu Ser Val Leu Gln Ser Gln Ala Thr Glu Leu Leu Gln Lys Lys I POUS 96IO912 JPENUS 18 D EC 1996 Ala Met Ile Asn Arg Thr Ile 145 Tyr Ile Gin G ly Asn Pro Met Ala 130 Thr Unk Unk Leu Val Ala Asn Asp Thr His Val 100 Ilie Thr 115 Leu Asn Arg Ser Unk Unk Unk Leu 180 Gin Phe Met Ala 105 Asp Unk Lys Leu Asn 185 Gly Leu Leu Ile Ser Pro Giu Unk 170 Ile INFORMATION FOR SEQ ID NO:779: SEQUENCE CHARACTERISTICS: LENGTH: 171 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .171 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:779 Met Asn Val Lys Lys Lys Giu Lys Pro Gin Ser Gly Lys Ile 1 Val Asp Ser Ile Val Gly Phe Tyr Gin Arg Leu Glu His Gly Ala Leu 130 Ile Gin 145 Cys Ala Val Asp Arg Met Thr 115 Cys Glu
S
Leu Giu Met Gly Leu Ile Val Ser Ile Glu Tyr Gin 100 Ile Lys Ala Gly Gly Met Lys Ser Giy Leu 70 Ile Asn Phe Asp Gly 150 Leu Ile Gly 55 Thr Giu Gin Phe Ala 135 Gin Gly Gly 40 Phe Ile Lys Phe Asn 120 Asp Glu Lys 25 Gin Val Phe Giu Asn 105 Giu Leu Leu 10 Giu Leu Gly Lys Cys 90 Glu Ser Ala Leu Asn Ala Gly Giu 75 Arg Val1 Phe Ile Phe Thr Thr Ile Pro Val Met Ala Lys Glu Ser Phe Giu Asp Giu 125 Ala Val 140 Asp Asn Phe Ile Ser Leu Ile Arg 110 Leu Asn Lys Asp Leu Pro Lys Ala Arg Tyr G lu Asn Gin Arg Ser Gly Thr Arg Gin Phe Arg Lys Giu 160 155 Cys Trp Glu Phe Ile 165 CysTrpGluPhelieThr Ser Arg Lys Glu Gly 165 170 POT/US 96/0912.2.
IPENAUS 18 DEC 1996 INFORMATION FOR SEQ ID NO:780: SEQUENCE CHARACTERISTICS: LENGTH: 141 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...141 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:780 Met Trp Pro Unk Lys Leu Phe Leu Lys Pro Leu Lys Glu Thr 1 Ala Gly Ile Thr Ile Lys Tyr Asn Leu Leu Lys Ala Val Leu Gly Leu 130 Val Lys Arg Leu Ala Phe Ile 115 Pro Gly Arg Tyr Leu Met Val 100 Ser Phe 5 Val Ala Leu Ala Ala Met Glu Ser Lys Leu Phe 55 Phe Met Tyr Val Pro 135 Asn Pro 40 Asp Gly Asn Pro Val 120 Ile lie Ser Gin Val 75 Set Leu Leu Pro Val Leu Pro Gly Lys Tyr Glu Lys 140 Ala Ile Phe Val Glu Thr Lys 125 Ala Ser Lys Phe Ser Val Glu Ser Phe Leu Ala Leu Ile Leu Lys Pro Pro INFORMATION FOR SEQ ID NO:781: SEQUENCE CHARACTERISTICS: LENGTH: 70 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...70 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:781 Met Val Ser Leu Leu Gly Ala Leu Lys Arg Thr Pro Cys Thr Asn Arg 1 5 10 Phe Tyr Leu Lys Ala Leu Leu Phe Ala Ile Phe Tyr His Ala Val Asn 25 Asn Phe Leu Thr Gln Cys Pro Pro His Gln Val Arg Glu Phe Phe Set X
I
I
1 PGT/US 9 6 091ZZ IPE/US 18 DEC 1996 649 40 Ser Arg His Ala Gln Gly Trp Lys Arg Glu Thr Leu Pro Cys Ala Leu 55 Ser Phe Gln Asn Ala Leu INFORMATION FOR SEQ ID NO:782: SEQUENCE
CHARACTERISTICS:
LENGTH: 153 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_ feature LOCATION 1...153 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:782 Val His His Leu Unk Arg Leu Leu Asp Ser Gly Ser Giu Arg Cys Ile 1 5 10 Gly Cys Gly Leu Cys Glu Lys Ile Cys Thr Ser Asn Cys Ile Arg Ile 25 Ile Thr His Lys Gly Glu Asp Asn Arg Lys Lys Ile Asp Ser Tyr Thr 40 Ile Asn Leu Gly Arg Cys Ile Tyr Cys Gly Leu Cys Ala Glu Val Cys 55 Pro Glu Leu Ala Ile Val Met Gly Asn Arg Phe Glu Asn Ala Ser Thr 70 75 Gin Arg Ser Gln Tyr Gly Ser Lys Ser Glu Phe Leu Thr Ser Glu Gin 90 Asp Ala Lys Asn Cys Ser His Ala Glu Phe Leu Gly Phe Gly Ala Val 100 105 110 Ser Pro Asn Tyr Asn Glu Arg Met Gln Ala Thr Pro Leu Asp Tyr Val 115 120 125 Gin GIu Pro Ser Lys Glu Glu Ser Lys Glu Glu Phe Unk Thr Ser Pro 130 135 140 Glu Ser His Lys Gly Asp Glu Asn Val 145 150 INFORMATION FOR SEQ ID NO:78 3 SEQUENCE CHARACTERISTICS: LENGTH: 183 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature PCT'S 9 6 091 IPEA/US 18 DEC1996 650 LOCATION 1...183 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:783 Met Ala Ile Trp Gly Trp Cys Phe Leu Phe Leu Ser Ser Leu Met Trp 1 5 10 Gly Ser Ser Met His Glu Leu Val Leu Arg Ser Gin Ala Leu Gly Phe 25 Glu Thr Arg Leu Val Gin Cys Asp Leu Ser Phe Ser Tyr Glu Arg Phe 40 Ile Ser Lys Thr Lys Arg Ser Leu Ala Val Leu Giu Glu Phe Asp Trp 55 Leu Asn Ser Gly Phe Asp Phe Ser Arg Leu Asn Val GIu Asn Asp Thr 70 75 Leu Glu Leu Leu Lys Ala Leu Tyr Phe Lys Leu Glu Lys Leu Glu Ser 90 Leu Leu Leu Lys Glu Asn Leu Leu Glu Leu Glu Gin Lys Asp Arg Ile 100 105 110 Ile Ala Leu Gly His Gly Leu Val Cys Leu Lys Lys Gin Ser Leu Ile 115 120 125 Ala Pro Gin Thr Tyr Tyr Gly Arg Cys Val Leu Glu Gly Lys Ile Leu 130 135 140 Ala Phe Phe Gly Val Ala Arg Asp Lys Asp Phe Leu Glu Ile Thr Arg 145 150 155 160 Met His Ala Leu Asp Ile Lys Arg Tyr Asp Ser Phe Ile Val Asp Ser 165 170 175 Glu Arg Lys Gly Leu Lys Leu 180 INFORMATION FOR SEQ ID NO:784: SEQUENCE
CHARACTERISTICS:
LENGTH: 67 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) .FEATURE: NAME/KEY: misc_feature LOCATION 1...67 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:784 Met Pro Glu Asn Ser Lys Leu Gin Pro Ala Lys Leu Gly Lys Asn Phe 1 5 10 Asp Pro Val Asp His Ser Asn Arg Asn Phe Phe Phe Ser Leu Ile Leu 25 Ser Val Leu Leu His Trp Leu Ile Tyr Phe Leu Phe Glu His Arg Glu 40 Asp Phe Phe Pro Ser Lys Pro Lys Leu Val Lys Leu Asn Pro Glu Asn 55 Leu Leu Val INFORMATION FOR SEQ ID NO:785: SEQUENCE CHARACTERISTICS: POUS 9 6/ 091 2a2.
IPEA/US 180DEC 1996 651 LENGTH: 253 amino acids I-B) TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .253 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:785 Met Ala Tyr Lys Tyr Asp Arg Asp Leu Giu Phe Leu Ser Gly Arg Leu Gly Val1 Leu Val Asn 145 Gly Lys Thr Gly Ile 225 Ala Ser Asp Giu Lys His Gly Gln Tyr Val Leu Asn Tyr Sen Lys 115 Lys Glu 130 Ang Gin Pho Lys Thr Ile Arg Thr 195 Val Trp 210.
Pro Ala Asn Glu Lou Arg Asp Tyr Tyr Asn 100 I le Met Ala Sen Lou 180 Leu Thn Cys Asp Leu His Asp Gly Lys Lys Leu Cys Lou Tyr 165 Gly Ser Ala Ile Lys 245 Asp Asn Tyr Sen 70 Giu Lys Glu Asp Ser 150 Gin Ang Phe Ile Val 230 Lys Lou Giu Ala 55 Asrt Ile Thr Arg Giu 135 Ala Lou Gly Leu Asp 215 Val Sen Pho Lys 40 Lys Sen Lou Glu Sen 120 Lou Ala Ala Lou Thr 200 Ile Ala Lou Giu 25 Lou Tyr Pho Cys Thr 105 Lou Ser Thn Val1 Ser 185 Gly Ala Thr Gin Val1 Thn Ala Ala Asp 90 Thn Giu Ile Lou Ile 170 Lou Pro Gly Lou Ile 250 Lou Ser Giu Ser 75 Val1 Lou Glu Lys Thr 155 Val1 Ala Val1 Pro Arg 235 Glu Val1 Sor Arg Phe Cys Ile Met Asn 140 Lou Ala Gly Gly Ala 220 Lou Sen Lys Phe Ile Ile Ile Asp Giu Asp 125 Thr Phe Asn Asn Trp 205 Tyr Lys Val1 Gin Lou Glu Gly Lys Asp Giu Tyr Lys Ala Giu Glu Lys Giy Giu Lys Lou Lys Gin Asn Met 110 Asp Glu Giu Asp Asn Lou Lys Met Gly 160 Ala Vai Ala 175 Gin Val Lou 190 Ile Ile Thr Arg Val Thr Thr Gin Gin 240 INFORMATION FOR SEQ ID NO:785: SEQUENCE CHARACTERISTICS: LENGTH: 253 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Holicobactor pylori PCTI'US 9 6I/091 !KOA/S 18 DEC 1996 652 (ix) FEATURE:fetr NAME/KEY: misc-fatr LOCATION .253 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:785 Met Ser Gly Arg Leu Gly Val Leu Val Asn 145 Gly Lys Thr G ly Ile 225 Ala Ser Glu His so Gin Val Asn Ser Lys 130 Arg Phe Thr Arg Val 210 Pro Tyr Asp Lys Gly Leu Tyr Lys 115 Giu Gin Lys le Thr 195 Trp Ala Lys Leu Arg Asp Tyr Asn 100 Ile Met Ala Ser Leu 180 Leu Thr Cys Tyr Asp Arg Asp Leu Giu Phe Leu Lys Gin Leu His Asp Gly Lys Lys Leu Cys Leu Tyr 165 Gly Ser Ala Ile Lys 245 Asp Asn Tyr Ser 70 Giu Lys Giu Asp Ser 150 Gin Arg Phe Ile Vali 230 Leu Giu Ala 55 Asn Ile Thr Arg Giu 135 Ala Leu Giy Leu Asp 215 Val1 Phe Lys 40 Lys Ser Leu Giu Ser 120 Leu Ala Aia Leu Thr 200 Ile Ala Giu 25 Leu Tyr Phe Cys Thr 105 Leu Ser Thr Vali Ser 185 G iy Ala Thr Val Leu Thr Ser Ala Giu Ala Ser 75 Asp Val 90 Thr Leu Giu Giu Ile Lys Leu Thr 155 Ile Val 170 Leu Ala *Pro Val *Gly Pro Leu Arg 235 Ile Giu 250 Val Ser Arg Phe Cys Ile Met Asn 140 Leu Ala Giy G iy Ala 220 Leu Phe Ile Ile Ile Asp Giu Asp 125 Thr Phe Asn Asn Trp 205 Tyr Lys Gly Giu Ala Lys Lys Gin 110 Asp Asp Lys Ala Gin 190 Ile Arg Thr Leu is Lys Tyr Giu Gly Leu Asn G iu Asn Met Val1 175 Vali Ile Vai Gin G iu Asp Lys Giu GiU Lys Met Giu Leu, Giy 160 Ala Leu Thr Thr Gin 240 Ala Asn Giu Asp Lys Ser Leu Gin Ser Val INFORMATION FOR SEQ ID NO:786: Ci) SEQUENCE CHARACTERISTICS: LENGTH: 173 amino acids TYPE: amino acid TOPOLOGY: iinear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyiori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .173 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:786 Val Phe Leu Val Gin Ser Trp Ala Leu Ser Leu Lys Ile Asp Ser Leu 1 5 10 Phe Ser Leu Phe Ser Vai Gly Lys Ile Pro Ser Gly Ser Lys Asp Pro 25 Phe Ala Leu Arg Arg Leu Ser Phe Gly Leu Leu Lys Ile Ile Aia H-is PCTPJS 96/U91Za? ANUS 16 u L 6 Tyr Lys Leu Arg Lys Lys Lys 145 Lys Gly Val Leu Ser Val1 Lys 130 Asp Glu Leu Gly Glu Val1 Lys 115 Glu Arg Leu -Glu Val1 Arg Leu 100 Ala Leu Asn Gin Phe Tyr Phe Asn Leu Leu Pro Glu 165 Asp Gln 70 His Thr Lys Phe Asn 150 His Leu 55 Ser Asni Asn Arg Ser 135 Glu Ala 40 Lys Phe Leu Glu Phe 120 Ala Ser Leu Asp Leu Leu Giu 75 Asp Cys 90 Asp Ile Asp Asn Lys Arg Gly Phe 155 Glu Ala 170 Lys Val1 Asri Val1 Pro Leu 140 Ser Phe Asn Leu Leu Lys Lys 125 Ala Thr Asn Leu G lu Ser I le 110 Asn Asn Ser Phe Lys Ile Ile Ala I le Leu Glu Phe Ile Gin Gln Asn Phe 160 INFORMATION FOR SEQ ID NO:787: SEQUENCE CHARACTERISTICS: LENGTH: 259 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .259 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:787 Met Ser Lou Ala Pro Ser Val Met Ala Gly Phe Leu Phe Cys Ala Gly 10c S 10 Ser Val Asp His Asn Ile Trp Arg Phe 145 Asp Ile Cys Asp Asn Leu Phe His Arg Gly 130 Lou Phe Lys Ser Lou Arg Phe Thr Giu Pro Lys Gin Glu 115 Lys Glu Phe Tyr Val Pro Phe Ile Gly 100 Asn Asp Arg Lys Lys Phe Thr Glu Asp Phe Gly Lou I le Glu 165 Pro Leu Lys Ala 70 Lou Asn Phe Phe.
Lou 150 His Pro Gly Lou 55 Phe Leu Met Glu Tyr 135 Glu Asn Tyr 25 Asp Val 40 Lou Gly Cys Asp Arg Phe Gly Phe 105 Lys Ile 120 Pro Glu Leu Pro Ala Ser Ala Met Val Phe Cys 75 Ser Gin 90 Lou Val Ala Leu Glii Cys Ile His 155 Arg Glu Asn Ala Glu Lou 140 Tyr Ser Lys Ile Tle Ser Ile Asp Tyr Phe Asp Thr Arg Thr Glu Leu Asn Lou 110 Phe Lou 125 Ile Asn Asn Cys Ala Phe Cys Lys Asp Lys Met Tyr Lou Ser Lys Arg Leu Thr Val Ser 160 Tyr Pro Lys Ser Ile Ile Met Lou His Phe 175 Trp Arg Ser Val Ser Ser Lou Asn 185 180 Ile Cys Tyr Glu 195 190 Lou Phe Cys Ala Glu Ala Phe Trp Lou Ala 205 7/ Thr Asp 225 Axg Giu 654 Phe Lys Asn Asp Phe Phe Lys Giu Arg Leu Glu Met Ala Lys 215 220 Gin Met Gin Ser Phe Lys Thr His Ile Arg Ser Lys Thr Ile 230 235 240 Tyr Phe Tyr Phe Arg Ile Lys Asn Ile Leu Lys Lys Val Phe 245 250 255 Ser INFORMATION FOR SEQ ID NO:788: SEQUENCE CHARACTERISTICS: LENGTH: 293 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .293 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:788 Leu Leu Leu Phe Ile Val Val Ile Thr Ser Leu Val 1 Pro Ala His Ala Ala Phe Trp Giy Arg 145 Ala Gly Trp Tyr Phe 225 Thx Arg Asn Ile Ser Sen Ser Met Leu Leu 130 Lys Ile Asn Gly Ala 210 Ile Leu Ang Ile Ala Pro Val Ser Asp Asn 115 Cys Gin Asn Phe Trp 195 Leu Leu Phe Unk Trp His Trp Ile Phe Pro 100 Ile Phe Gly Giu Leu 180 Asp Ile Ala Trp Ser 5 Leu Ser Ser Ala Leu Gin His Val Arg Met 165 Gly Pro Leu Ser Arg 245 Phe Thr Val1 Asn Gly 70 Ala Ile Val Leu Phe
ISO
Sen Gly Lys His Sen 230 Giu Ala Lys Gly Ala 55 Phe Gly Gly Ser Gly 135 Asn Met Val Glu Leu 215 Ser Leu Asp Ile Unk 40 Tyr Val1 Ile Pro Val1 120 Ile Leu Ile Tnp Thr 200 Arg Val1 Leu Pro Leu 25 Ile Giu Leu Ala Leu 105 Ile Leu Asp Leu Ala 185 Trp Phe Leu Pro Tyr 265 10 Tyr Leu Sen Arg Leu 90 Val1 Thr Sen Lys Gly 170 Asn Ala Leu Gly Phe 250 Phe Tyr Met Ang Met Unk 75 Phe Pro Ala Leu Thr 155 Leu Giu Leu Gly Phe 235 Trp Phe Phe Ala Trp Phe Lys Val1 Val1 Ser Val 140 Ile Phe Ser Ile Sen 220 Leu Ile Lys Lys Ile Tyr Tyn Leu Ala Leu Tyr 125 Leu Leu Met Trp Sen 205 Gin Ser Ala Leu Arg As n Leu Val1 Ile Ala His Lys 110 Gly Phe Sen Leu Gly 190 Ile Asn Val1 Gin Phe 270 His Thr Leu Sen Ala Leu Leu Ser Phe Ile Ile Thn 175 Ang Cys Trp Leu Leu 255 Gly Leu Ile Cys Gly Trp Sen Giy Tyr Leu Leu Sen 160 Ala Tyr Val Pro Met 240 Cys Ser Sen 260 Asp Thr Phe Ang Sen Arg Ile Leu Ala PffiUS 961i0 9 1 d iL [PEA/JS 18 D C 1996 275 Leu Pro Lys- Leu Val 290 285 INFORMATION FOR SEQ ID NO:788: SEQUENCE CHARACTERISTICS: LENGTH: 293 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1 .293 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:788 Leu Leu Leu Phe Ile Val Val Ilie Thr Ser Leu Val Lys Asn Thr Ile 1 Pro Ala His Ala Ala Phe Trp Gly Arg 145 Ala Gly Trp Tyr Phe 225 Thr Arg Asp Leu Asn Ile Ser Ser Sen Met Leu Leu 130 Lys Ile Asn Gly Ala 210 Ile Leu Arg Thr Pro 290 Ile Ala Pro Val1 Sen Asp Asn 115 Cys Gin Asn Ph.
Trp 195 Leu Leu Ph.
Unk Ph.
275 Lys 5 Trp Leu His Ser Trp Ser Ile Ala Phe Leu Pro Gin 100 Ile His Phe Val Gly Arg Glu Met 165 Leu Gly 180 Asp Pro Ile Leu Ala Sen Trp Arg 245 Ser Ph.
260 Arg Ser Leu Val Thr Val1 As n Gly 70 Ala Ile Val Leu Ph.
150 Sen Gly Lys His Ser 230 Giu Ala Arg Lys Gly Ala 55 Ph.
Gly Gly Ser Gly 135 Asn Met Val Glu Leu 215 Sen Leu Asp Ile Ile Unk 40 Tyr Val1 Ile Pro Val 120 Ile Leu Ile Trp Thn 200 Ang Val1 Leu Pro Leu 280 Leu 25 Ile Giu Leu Ala Leu 105 Ile Leu Asp Leu Ala 185 Trp Phe Leu Pro Tyr 265 10 Tyr Leu Ser Arg Leu 90 Val Thr Ser Lys Gly 170 Asn Ala Leu Gly Phe 250 Ph.
Met Arg Met Unk 75 Ph.
Pro Ala Leu Thr 155 Leu Giu Leu G ly Ph.
235 Trp Phe Ala Trp Ph.
Lys Va 1 Val1 Ser Val 140 Ile Ph.
Sen Ile Sen 220 Tyn Leu Ile Ile Tyr Tyr Leu Ala Leu Tyr 125 Leu Leu Met Trp Sen 205 Gin Sen Ala Leu Ang 285 Leu Val1 Ile Ala His Lys 110 Gly Ph.
Sen Leu Gly 190 Ile Asn Val1 Gin Ph.
270 Leu Sen Ala Leu Leu Ser Ph.
Ile Ile Thr 175 Arg Cys Trp Leu Leu 255 Gly Cys Gly Trp Sen Gly Tyn Leu Leu Sen 160 Ala Tyr Val Pro Met 240 Cys Sen Ala Tyr Phe Lys His Leu Ser -~r P T/US 9 6 091 2 2 SEA/US 1 UEC 1996 656 INFORMATION FOR SEQ ID NO:789: SEQUENCE CHARACTERISTICS: LENGTH: 194 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...194 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:789 Val Ile Val Cys Ser Ala Ala Gly Leu Ser His Phe Phe Gly Phe Ser 1 5 10 Met Ser Leu Gly Ala Phe Ile Val Gly Met Ala Ile Ser Lys Ser Arg 25 Tyr Lys Ile Asn Val Gln Glu Glu Phe Ala Gln Leu Lys Asn Leu Phe 40 Leu Ala Leu Phe Phe Ile Thr Ile Gly Met Gln Ile Asn Val Ser Phe 55 Phe Met Glu Lys Phe Phe Val Val Ile Phe Leu Leu Ile Leu Val Met 70 75 Ser Phe Lys Thr Phe Ile Ile Tyr Ala Leu Leu Arg Phe Phe Arg Asp 90 Ala Lys Thr Ala Ile Lys Thr Ala Leu Ser Leu Ala Gln Ile Gly Glu 100 105 110 Phe Ser Phe Val Ile Phe Leu Asn Ser Gly Ser His Gln Leu Phe Asn 115 120 125 Leu Gln Glu Lys Lys Gly Ile Leu Gly Phe Leu His Gln Lys Asn Ile 130 135 140 Leu Asn Ile Ala Gln Asn Asp Ile His Gln Leu Leu Ile Leu Met Val 145 150 155 160 Val Phe Ser Met Leu Ala Thr Pro Phe Ile Leu Lys Tyr Leu Glu Ser 165 170 175 Ile Ala Gln Phe Ile Leu His Gln Lys Ser Gin Glu Asn Glu Pro Ala 180 185 190 Lys Lys INFORMATION FOR SEQ ID NO:790: SEQUENCE CHARACTERISTICS: LENGTH: 132 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...132 PCT/US 96/09122 IPENUS 18 DLU 1996 657 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:790 Met Phe Tyr Leu Ile Asn Thr Gly Val Pro His Leu Val Gly Phe Val 1 5 10 Lys Asn Lys Gly Leu Leu Asn Ser Leu Asn Thr Leu Glu Leu Arg Ala 20 25 Leu Arg His Glu Phe Asn Ala Asn Ile Asn Ile Ala Phe Ile Glu Asn 40 Lys Glu Thr Ile Phe Leu Gin Thr Tyr Glu Arg Gly Val Glu Asp Phe 55 Thr Leu Ala Cys Gly Thr Gly Met Ala Ala Val Phe Ile Ala Ala Arg 70 75 Leu Phe His Asn Thr Pro Lys Lys Ala Thr Leu Ile Pro Lys Ser Asn 90 Glu Phe Leu Glu Leu Ser Leu Lys Asn Asp Gly Ile Phe Tyr Lys Gly 100 105 110 Val Ala Arg Tyr Ile Gly Met Ser Val Leu Gly Met Gly Val Phe Lys 115 120 125 Asn Gly Cys Phe 130 INFORMATION FOR SEQ ID NO:791: SEQUENCE CHARACTERISTICS: LENGTH: 213 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...213 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:791 Met Ile Lys Ala Ile Asp Ile Ser His Asp Phe Glu Lys Pro Leu Tyr 1 5 10 Asn Gly Val Asn Leu Arg Ile Lys Pro Lys Glu Ser Met Glu Ile Leu 25 Gly Val Ser Gly Ser Gly Lys Ser Thr Leu Ile Ser His Leu Ala Thr 40 Met Leu Lys Pro Asp Ser Gly Thr Val Ser Leu Leu Glu His Gin Asp 55 Ile Tyr Ala Leu Asn Ser Lys Lys Leu Leu Glu Leu Arg Arg Leu Lys 70 75 Val Gly Ile Val Phe Gin Ser His Tyr Leu Phe Lys Gly Phe Ser Ala 90 Leu Glu Asn Leu Gin Val Ala Ser Ile Leu Ala Lys Gin Glu Ile Asn 100 105 110 His Ser Leu Leu Glu Gin Leu Gly Ile Ala His Thr Leu Lys Gin Gly 115 120 125 Val Gly Glu Leu Ser Gly Gly Gin Gln Gin Arg Leu Ser Ile Ala Arg 130 135 140 Val Leu Ser Lys Lys Pro Gin Ile Ile Ile Ala Asp Glu Pro Thr Gly 145 150 155 160 Asn Leu Asp Thr Thr Ser Ala Asn Gln Val Ile Ser Met Leu Gin Asn 165 170 175 AA~r'y- Tn t-st PCT/US 9 6 091 2 2 PENUS 18 DEC1996 658 Tyr Ile Thr Glu Asn Glu Gly Ala Leu Val Leu Ala Thr His Asp Glu 180 185 190 His Leu Ala Phe Thr Cys Ser Gin Val Tyr Arg Leu Glu Lys Glu Ser 195 200 205 Leu Ile Lys Glu Lys 210 INFORMATION FOR SEQ ID NO:792: SEQUENCE CHARACTERISTICS: LENGTH: 47 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc feature LOCATION 1...47 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:792 Met Leu Asp Lys Arg Ile Lys Thr Leu Leu Leu Phe Phe Gly Leu Asn 1 5 10 Met Val Cys Leu Ser Val Ser Phe Thr Asn Lys Pro His Leu Cys Phe 25 Trp Phe Leu Val Leu Gly Cys Tyr Leu Val Tyr Glu Trp Gin Lys 40 INFORMATION FOR SEQ ID NO:793: SEQUENCE CHARACTERISTICS: LENGTH: 142 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...142 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:793 Val Glu Met Ile His Thr Gin Asp Tyr Ile Lys Met Glu Glu Ala Ala 1 5 10 Thr Glu Ala Ile Lys Arg Lys Glu Ser Ser Ile Tyr Leu Gly Met Asp 25 Ile Leu Lys Asn Gly Ala Asp Ala Leu Ile Ser Ala Gly His Ser Gly 40 Ala Thr Met Gly Leu Ala Thr Leu Arg Leu Gly Arg Ile Lys Gly Val 55 lu Arg Pro Ala Ile Cys Thr Leu Met Pro Ser Val Gly Lys Arg Pro ,2) CT 9 6 091 2 2 IPEAUS 18 DEC1996 659 75 Val Leu-Leu Asp Ala Gly Ala Asn Thr Asp Cys Lys Pro Glu Tyr 90 Ile Asp Phe Ala Leu Met Gly Tyr Glu Tyr Ala Lys Ser Val Leu 100 105 110 Tyr Asp Ser Pro Lys Val Gly Leu Leu Ser Asn Gly Glu Glu Asp -115 120 125 Lys Gly Gly Ile Arg Ser Leu Lys Lys Arg Ile Lys Cys 130 135 140 INFORMATION FOR SEQ ID NO:793: SEQUENCE CHARACTERISTICS: LENGTH: 142 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...142 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:793 Val Glu Met Ile His Thr Gln Asp Tyr Ile Lys Met 1 5 10 Thr Glu Ala Ile Lys Arg Lys Glu Ser Ser Ile Tyr 25 Ile Leu Lys Asn Gly Ala Asp Ala Leu Ile Ser Ala 40 Ala Thr Met Gly Leu Ala Thr Leu Arg Leu Gly Arg 55 Glu Arg Pro Ala Ile Cys Thr Leu Met Pro Ser Val 70 75 Ser Val Leu Leu Asp Ala Gly Ala Asn Thr Asp Cys 90 Leu Ile Asp Phe Ala Leu Met Gly Tyr Glu Tyr Ala 100 105 His Tyr Asp Ser Pro Lys Val Gly Leu Leu Ser Asn 115 120 Ile Lys Gly Gly Ile Arg Ser Leu Lys Lys Arg Ile 130 135 140 INFORMATION FOR SEQ ID NO:794: SEQUENCE CHARACTERISTICS: LENGTH: 69 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori Glu Leu Gly Ile Gly Lys Lys Gly 125 Lys Glu Ala Ala Gly Met Asp His Ser Gly Lys Gly Val Lys Arg Pro Pro Glu Tyr Ser Val Leu 110 Glu Glu Asp Cys pGT/ 0 0 91 2 2 660 (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...69 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:794 Met Lys Thr Ile Lys Asn Gly Ile Met Ile Gly Thr Leu Gly Ala Leu 1 5 10 Leu Leu Ser Gly Cys Ser Ser Phe Asp Ala Gln Arg Phe Ala Cys Leu 25 Pro Lys Asp His Ser Ser Lys Asp Ala Ser Thr Lys Lys Glu Ala Gln 40 Tyr Ile Pro Lys Gly Phe Phe Asp Pro Tyr Ser Ser Asn Leu Asn His 55 Trp Asp Ser Thr Phe INFORMATION FOR SEQ ID NO:795: SEQUENCE
CHARACTERISTICS:
LENGTH: 144 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori fix) FEATURE: NAME/KEY: misc_feature LOCATION 1...144 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:795 Met Leu Glu Ile Lys Asn Leu Asn Cys Val Leu Asn Ser His Phe Ser 1 5 10 Leu Gln Asn Ile Asn Ile Ser Leu Ser Tyr Ser Giu Arg Val Ala Ile 25 Val Gly Glu Ser Gly Ser Gly Lys Ser Ser Ile Ala Asn Leu Val Met 40 Arg Leu Asn Pro Arg Phe Lys Ser His Asn Gly Glu Ile Leu Phe Glu 55 Thr Thr Asn Leu Leu Lys Glu Ser Glu Ala Phe Unk Gin His Leu Arg 70 75 Gly Asn Ile Ile Ala Tyr Ile Ala Gln Asp Pro Leu Ser Ser Leu Asn 90 Pro Leu His Lys Ile Gly Lys Gln Met Ser Glu Ala Tyr Phe Leu His 100 105 110 His Lys Asn Ala Ser Gin Val Ser Leu Asn Glu Gln Val Leu Asn Val 115 120 125 Met Lys Gin Val Gln Leu Asp Glu Asn Phe Trp Asn Val Ser Leu Met 130 135 140 INFORMATION FOR SEQ ID NO:795: SEQUENCE CHARACTERISTICS: LENGTH: 144 amino acids TYPE: amino acid TOPOLOGY: linear /ii PCr7 06/91 2.
I pL 6 1 ±~ci9 6 661 (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...144 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:795 Met Leu Glu Ile Lys Asn Leu Asn Cys Val Leu Asn Ser His 1 Leu Val Arg Thr Gly Pro His Met Gin Gly Leu Thr Asn Leu Lys Lys 130 Ser Gly Lys Glu Ile Lys Val Asp 135 Leu Lys Ser Ser Ala Gin Ser 120 Glu Ser Ser His Glu Gin Met 105 Leu Asn 10 Tyr Ser Asn Ala Asp Ser Asn Phe Ser Ile Gly Phe 75 Pro Glu Glu Trp INFORMATION FOR SEQ ID NO:796: SEQUENCE CHARACTERISTICS: LENGTH: 190 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...190 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:796 Met Glu Leu Ile Leu Gly Ser Gln Ser Ser Ala 1 5 10 Lys Glu His Gly Ile Lys Phe Glu Gln Lys Ala 25 Glu Ser Leu Lys Thr Thr Asp Pro Arg Glu Phe 40 Lys Gly Lys Leu Glu Lys Ala Lys Glu Leu Leu 55 Ile Val Val Ala Asp Ser Val Val Ser Val Gly 70 75 Lys Ala Lys Asn Lys Arg Glu Ala Leu Glu Phe 90 'he Ser ,la Ile lal Met 'he Glu ,eu Arg ,eu Asn -eu His ksn Val ,eu Met Leu Leu Asp Glu Ala Cys Cys Ala Gin Arg Gin Asn Arg Ala Leu Tyr Val Tyr Ala Asn Asn Arg Leu Lys Asn Phe Leu Asn Met Arg -r LlaIS, Gly Leu Asp Ser 145 Ser Leu Asn Glu Glu Trp 115 Cys Ser 130 Ala-Gly Ser Ser Leu Gly Ile 100 Leu Glu Cys Lys Ala 180 Glu Asp Ile Val Asn 165 Leu Val Leu Glu Arg 150 Leu Lys Ser Arg Glu Phe Leu 170 Lys Ala Ala Ser His 155 Gly Leu Leu Arg Gly 140 Lys Leu Ser Val Phe Gly Lys 160 Gly INFORMATION FOR SEQ ID NO:797: SEQUENCE CHARACTERISTICS: LENGTH: 83 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...83 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:797 Met Asn Tyr Lys Val Ala Ser Ala Arg Asn Ile Ala Thr Leu Leu Phe 1 5 10 Leu Phe Phe Ser Gln Ser Glu Ala Phe Asp Leu Gly Lys Ile Ala Lys 25 Ile Lys Ala Gly Ala Glu Ser Phe Ser Lys Val Gly Phe Asn Asn Lys 40 Pro Ile Asn Unk Asn Lys Gly Ile Tyr Pro Thr Glu Thr Phe Met Thr 55 Ile Asn Gly Leu His Ala Gly Gly Phe Tyr Gly Ala Leu Ala Gln Lys 70 75 Arg Tyr Gly INFORMATION FOR SEQ ID NO:797: SEQUENCE CHARACTERISTICS: LENGTH: 83 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...83 PC'. /091 2 E996 663 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:797 Met Asn Tyr Lys Val Ala Ser Ala Arg Asn Ile Ala Thr Leu Leu Phe 1 5 10 Leu Phe Phe Ser Gin Ser Glu Ala Phe Asp Leu Gly Lys Ile Ala Lys 25 Ile Lys Ala Gly Ala Glu Ser Phe Ser Lys Val Gly Phe Asn Asn Lys 40 Pro Ile Asn Unk Asn Lys Gly Ile Tyr Pro Thr Glu Thr Phe Met Thr 55 Ile Asn Gly Leu His Ala Gly Gly Phe Tyr Gly Ala Leu Ala Gln Lys 70 75 Arg Tyr Gly INFORMATION FOR SEQ ID NO:798: SEQUENCE CHARACTERISTICS: LENGTH: 135 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...135 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:798 Met Leu Ile Leu Gly His Pro Leu Ile Pro Ser Ala Arg Phe Val Phe 1 5 10 Ile Lys Asn Thr Asp Ala Ile His Ser Ser Ala Asn Asn Asp Ile Val 25 Cys Phe Glu Ala Asn Pro Lys Asn Leu Glu Leu Ala Gln Tyr Cys Cys 40 Glu Asn Gly Val His Phe Ser Val Ile Phe Leu Ser His Lys Ile Glu 55 Thr Asp Thr Phe Phe Leu Phe Asn Ala Phe Lys Pro Leu Tyr Cys Ile 70 75 Phe Lys Asp Ile Lys Gln Ala Ile Leu Ala Gln Gln His Ala Thr Asn 90 Tyr Leu Leu Asp Ser Lys Ile Leu Phe Ser Met Asp Phe Asn Asp Thr 100 105 110 Glu Ser Trp Glu Ile Cys Ala Lys Asn Gln Ile Asp Gly Val Ile Ser 115 120 125 Lys Asp Ser Leu Leu Leu Lys 130 135 INFORMATION FOR SEQ ID NO:799: SEQUENCE CHARACTERISTICS: LENGTH: 255 amino acids TYPE: amino'acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein Pr 0O91 2.
IPENUS 15u -%9 (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori
FEATURE:
NAME/KEY: misc-feature LOCATION 1. 255 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:799 Met Lys Lys Arg Leu Asn Ile Gly Leu Val Gly Leu Gly Cys Val Gly 1 Ser Thr Arg Ala Lys Lys Val Ile Val Glu Ala Phe Leu Glu Cys Gly 130 Asn His 145 Ile LeU Lys Asp Ile Lys Ala Tyr 210 Giu Lys 225 Ser Ile Val1 Gly His Glu Ala Val Gin 115 Gly Ile Sen Ala G ly 195 Gly Ile Lys Ala Val Lys Asp Pro Thr 100 Ilie Ile Leu Gin Gin 180 Ile Ile Giu Leu
S
Lys Giu Gly Lys Tyr Ala Ala Pro Se r Met 165 His Asp Asp Pro Leu 245 Ile Ile Tyr G ly 70 Leu Asn Lys Ile Phe 150 Phe Leu Ala Ala Asp 230 Gly Leu Lys Ala 55 Ile Leu Lys Asn Ile 135 Lys Lys Gly Ala Lys 215 Asp Ile Gin Ile 40 Phe Asp Ala Ala Thr 120 Lys Gly Asn Tyr His 200 Leu Met G lu 25 Lys Giu Ile Lys Met 105 Pro Ala Ile Gin Ala 185 Lys Glu Glu 10 Asn Gin Lys Ala Ile Ser Val Val 75 Lys Thr 90 Leu Ala Ile Gly Leu Lys Leu Asn 155 Ala Ser 170 Giu Leu Leu Leu Giu Ile Phe Ala 235 Giu Val1 Asp Giu Leu Tyr Phe Asp 140 G ly Phe Asn Ile Leu 220 Lys Ile Val1 Asp Leu Ala His Glu 125 Gly Thr Lys Pro Leu 205 Ile Glu Ile Arg Leu Met Lys Arg 110 Ala Leu Sen Asp Glu 190 Ala Giu Phe Lys Asp Glu Gly Gin Tyr Ser Ser Asn Ala 175 Phe Ser Gly Gly His 255 Asp Val Ser Gly Lys Glu Val1 Ala Tyr 160 Leu Asp Leu Ile Tyr 240 Ala Lys Lys 250 His Gin Gly Leu INFORMATION FOR SEQ ID NO:800: SEQUENCE CHARACTERISTICS: LENGTH: 243 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc-feature LOCATION .243 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:800 PCTP' 21 IPEAAS 18fDEC 1996 Met Ile Gly Glu Ilie Asp Gly Phe Asn Gly 145 Asp Leu Gly Ala Thr 225 Gin Gin Glu* Lys Giu Pro Ser Lys Thr Val Giu Lys Ala Asn Phe Phe Giu 115 Ala Val 130 Giu Cys Lys Thr.
Leu Asn Met Ala 195 Asn Thr 210 Thr Leu Gly Phe Lys Ile Lys Asp Met Thr Asn 100 Leu Leu Phe Ala Lys 180 Phe Leu Arg Giu Met Ala Ile Met Ala Ser Arg As n His 165 Asp Gin Gly Leu Ser Leu Ile Gin 70 Arg Val1 Lys Leu Ser 150 Phe Ala Ile Lys Lys Giy Arg Leu 55 Thr Arg Met Met Se r 135 Asp Ile Lys Ile Pro 215 Ala Phe Ser 40 Leu Ala Lys Leu Gly 120 Arg Lys Giu Met Asp 200 Asn Ile Ile 25 Lys Asp Ser Leu Gly 105 Giu Gly Gin Ala Tyr 185 Asp Phe Gin 10 Asp Leu Lys Leu Pro 90 Asp Ser Giu Lys Ser 170 Ala Leu Ser As n Ala Met Ala Leu 75 Ser Val1 Ile Ile Tyr 155 Leu Asp Leu Asp Lys 235 Lys Leu Leu Leu His Ile Phe Ala Giu 140 Trp Lys Phe Asp Phe 220 Ile Phe Ala Asn Asp Asn Tyr Gin 125 Asp Arg Ser dly Ile 205 Lys Ala Ser Leu Leu Asp Ala Ser 110 Ala Val1 Ile Met Leu 190 Thr Glu Ser Lys Leu Cys Val1 Leu Lys Leu Phe Leu Ala 175 His Gin Gly Trp Ile Asp Ala Ile Phe Ala Ser Val1 Glu 160 Ile Phe Asp Lys Pro Tyr Leu Leu Leu Tyr Giu 230 Leu Asn Gin His Giu 240 INFORMATION FOR SEQ ID NO:801: SEQUENCE CHARACTERISTICS: LENGTH: 252 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii). HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .252 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:801 Met Leu Gly Lys Lys Asn Glu Giu Val Leu Ile Asp Giu Asn Leu 1 5 10 Gly Gly Val Ile Ala Leu Asp Arg Leu Ala Lys Leu Asn Lys Ala 25 Arg Thr Phe Lys Arg Ala Phe Tyr Leu Ser Met Val Leu Asn Val 40 Ala Val Thr Ser Ile Val Met Met Met Pro Leu Lys Lys Thr Asp 55 Phe Val Tyr Gly Ile Asp Arg Tyr Thr Giy Glu Phe Lys Ile Val 70 N'J 1V I 7AmFnn comm IPEAUS 1 DEC 1996 666 Arg Ser Asp-Ala Arg Gln Ile Val Asn Ser Giu Ala Val Val Asp Ser 90 Ala Thr Ser Lys Phe Val Ser Leu Leu Phe Gly Tyr Ser Lys Asn Ser 100 105 110 Leu Arg Asp Arg Lys Asp Gln Leu Met Gln Tyr Cys Asp Val Ser Phe 115 120 125 Gin Thr Gln Ala Met Arg Met Phe Asn Glu Asn Ile Arg Gln Phe Val 130 135 140 Asp Lys Val Arg Ala Glu Ala Ile Ile Ser Ser Asn Ile Gln Arg Glu 145 150 155 160 Lys Val Lys Asn Ser Pro Leu Thr Arg Leu Thr Phe Phe Ile Thr Ile 165 170 175 Lys Ile Thr Pro Asp Thr Met Glu Asn Tyr Glu Tyr Ile Thr Lys Lys 180 185 190 Gin Val Thr Ile Tyr Tyr Asp Phe Ala Arg Gly Asn Ser Ser Gln Glu 195 200 205 Asn Leu Ile Ile Asn Pro Phe Gly Phe Lys Val Phe Asp Ile Gln Ile 210 215 220 Thr Asp Leu Gln Asn Glu Gln Thr Val Ser Glu Ile Leu Arg Lys Ile 225 230 235 240 Lys Glu Val Glu Ser Lys Asn Lys Ala Leu Asn Lys 245 250 INFORMATION FOR SEQ ID NO:802: SEQUENCE CHARACTERISTICS: LENGTH: 165 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...165 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:802 Met Arg Ala Ile Ala Ile Val Leu Ala Arg Ser Ser Ser Lys Arg Ile 1 5 10 Lys Asn Lys Asn Met Ile Asp Phe Phe Asn Lys Pro Met Leu Ala Tyr 25 Pro Ile Glu Thr Ala Leu Asn Ser Lys Leu Phe Glu Lys Val Phe Ile 40 Ser Ser Asp Ser Met Glu Tyr Val Asn Leu Ala Lys Asn Tyr Gly Ala 55 Ser Phe Leu Asn Leu Arg Pro Lys Asn Leu Ala Asp Asp Arg Ala Thr 70 75 Thr Leu Glu Val Met Ala Tyr His Met Lys GIu Leu Glu Leu Lys Asp 90 Glu Asp Ile Ala Cys Cys Leu Tyr Gly Val Ser Val Phe Leu Gln Glu 100 105 110 Lys His Leu Gln Asn Ala Phe Glu Thr Leu Lys Gln Asn Gln Asn Thr 115 120 125 Asp Tyr Val Phe Thr Cys Ser Pro Phe Ser Ala Ser Pro Ile Val Leu 130 135 140 Leu Ala Leu Lys Thr Ala Phe Lys Trp Leu Leu Lys Ser Ile Gln Thr 'AI 1 n 1i5 160 Arg Ala Arg Lys Ile PGT/US 9 6 6PL'US lo JU 1996 667 165 INFORMATION FOR SEQ ID NO:803: SEQUENCE CHARACTERISTICS: LENGTH: 171 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...171 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:803 Met Ser Asn Gln Ala Ser His Leu Asp Asn Phe Met Asn Ala Lys Asn 1 5 10 Pro Lys Ser Phe Phe Asp Asn Lys Gly Asn Thr Lys Phe Ile Ala Ile 25 Thr Ser Gly Lys Gly Gly Val Gly Lys Ser Asn Ile Ser Ala Asn Leu 40 Ala Tyr Ser Leu Tyr Lys Lys Gly Tyr Lys Val Gly Val Phe Asp Ala 55 Asn Ile Gly Leu Ala Asn Leu Asp Val Ile Phe Gly Val Lys Thr Gin 70 75 Lys Asn Ile Leu His Asp Leu Lys Gly Glu Asp Lys Leu Lys Glu Ile 90 Ile Cys Glu Ile Glu Pro Gly Leu Cys Leu Ile Pro Gly Asp Ser Gly 100 105 110 Glu Glu Ile Leu Lys Tyr Ile Ser Glu Ala Glu Asp Phe Asp Ser Phe 115 120 125 Leu Asp Glu Glu Gly Val Leu Ser Ala Leu Ile Tyr Ile Leu Ile Asn 130 135 140 Thr Phe Ser Lys Asn Leu Gly Pro Leu Ser Gln Thr Phe Leu Asn Phe 145 150 155 160 Gin Ser Phe Leu Phe Ile Phe Ile Gln Ser Pro 165 170 INFORMATION FOR SEQ ID NO:804: SEQUENCE CHARACTERISTICS: LENGTH: 62 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...62 PCT/US 96/091 2 IPENUS 1 1996 668 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:804 Met Gin His Leu Val Leu Ile Gly Phe Met Gly Ser Gly Lys Ser Ser 1 5 10 Leu Ala Gin Glu Leu Gly Leu Ala Leu Lys Leu Glu Val Leu Asp Thr 25 Asp Met Ile Ile Ser Glu Arg Val Gly Leu Ser Val Arg Gly Ile Phe 40 Glu Glu Leu Gly Glu Asp Asn Phe Arg Met Phe Glu Lys Ile 55 INFORMATION FOR SEQ ID NO:805: SEQUENCE CHARACTERISTICS: LENGTH: 199 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...199 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:805 Met Ser Ile Lys Glu Asn Leu Glu Gin Val Arg Asn Glu Phe Lys Ser 1 5 10 Asp Glu Lys Leu Leu Glu Gly Ala Phe Arg Leu Glu Lys Phe Phe Lys 25 Arg Tyr Lys Trp Val Leu Leu Phe Ile Val Val Ala Phe Ile Ala Tyr 40 Leu Gly Asp Thr Lys Leu Gin Asp Tyr Lys His Glu Gin Thr Arg Glu 55 Arg Ile Thr Gin Ile Tyr Asn Glu Val Leu Glu Ser Pro Asn Asn Ile 70 75 Ala Leu Gln Lys Arg Leu Lys Glu Val Ala Pro Glu Leu Tyr Asp Leu 90 Tyr Gin Phe Ala Arg Ala Ser Glu Arg Asn Asp Ala Asn Glu Phe Lys 100 105 110 Arg Leu Ser Gin Ser Ser Asn Glu Ile Val Lys Ala Phe Ala Lys Tyr 115 120 125 Ser Tyr Ala Ser Leu Ser Arg Asp Lys Asn Leu Leu Glu Lys Ser Pro 130 135 140 Ile Leu Lys Glu Met Ser Ala Leu Gin Glu Val Asn Leu Leu Tyr Glu 145 150 155 160 Glu Asn Ser Lys Asp Ala Ile Lys Lys Ala His Gin Ser Leu Ser Thr 165 170 175 Ile Pro Leu Ser Ser Ser Leu Tyr Ala Ile Ile Ser Val Leu Lys His 180 185 190 Tyr Gly Met Leu Glu Asp Ile 195 INFORMATION FOR SEQ ID NO:806: SEQUENCE CHARACTERISTICS: LENGTH: 130 amino acids TYPE: amino acid 7.-w IPEAUS 18 DEC 1996 669 TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...130 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:806 Met Asp Ala Leu Glu Ile Thr Gin Lys Leu Ile Ser Tyr Pro Thr Ile 1 5 10 Thr Pro Lys Glu Cys Gly Ile Phe Glu Tyr Ile Lys Ser Leu Phe Pro 25 Ala Phe Lys Thr Leu Glu Cys Glu Lys Asn Gly Val Lys Asn Leu Phe 40 Leu Tyr Arg Ile Phe Asn Pro Leu Lys Lys His Ala Glu Lys Glu His 55 Ala Lys Giu Lys His Val Lys Glu Asn Val Unk Pro Leu His Phe Cys 70 75 Unk Ala Gly His Ile Unk Val Val Pro Pro Gly Unk Unk Unk Unk Unk 90 Asp Ser Phe Unk Unk Ile Ile Lys Glu Gly Phe Leu Tyr Gly Arg Gly 100 105 110 Ala Gln Asp Met Lys Gly Gly Val Gly Unk Phe Unk Arg Cys Unk Unk 115 120 125 Lys Phe 130 INFORMATION FOR SEQ ID NO:806: SEQUENCE CHARACTERISTICS: LENGTH: 130 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii).HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...130 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:806 Met Asp Ala Leu Glu Ile Thr Gln Lys Leu Ile Ser Tyr Pro Thr Ile 1 5 10 Thr Pro Lys Glu Cys Gly Ile Phe Glu Tyr Ile Lys Ser Leu Phe Pro 25 Ala Phe Lys Thr Leu Glu Cys Glu Lys Asn Gly Val Lys Asn Leu Phe 40 Leu Tyr Arg Ile Phe Asn Pro Leu Lys Lys His Ala Glu Lys Glu His 55 Ala Lys Glu Lys His Val Lys Glu Asn Val Unk Pro Leu His Phe Cys 70 75 A'1-,7 A o f' 4'fo^.i. PCT/US 9o 0 9 i IPEA/US 1 DEC1996 1 670 Unk Ala Gly. His Ile Unk Val Val Pro Pro Gly Unk Unk U 90 Asp Ser Phe Unk Unk Ile Ile Lys Glu Gly Phe Leu Tyr G 100 105 1 Ala Gln Asp Met Lys Gly Gly Val Gly Unk Phe Unk Arg C 115 120 125 Lys Phe 130 INFORMATION FOR SEQ ID NO:807: SEQUENCE
CHARACTERISTICS:
LENGTH: 101 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...101 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:807 Val His Phe Asn Gln Val Val Leu Pro Lys Gly Val Gly 1 5 10 Val Ala Pro Lys Gly Pro Gly Ser Ala Leu Arg Glu Glu 25 Asn Arg Gly Leu Tyr His Leu Ile Ala Ile Glu Gln Glu 40 His Asn Ala Lys Ala Val Ala Leu Ser Tyr Ala Lys Ala 55 Gly Arg Met Gly Val Leu Glu Thr Ser Phe Lys Glu Glu 70 75 Asp Leu Phe Gly Glu Gln Ala Val Leu Cys Gly Gly Leu Arg Lys Asn Gly Val 100 nk Unk Unk ly Arg Gly 10 ys Unk Unk Ala Ile Tyr Leu Ser Ser Met Gly Cys Glu Glu Val Leu Lys Ile Gly Ser Asp INFORMATION FOR SEQ ID NO:808: SEQUENCE CHARACTERISTICS: LENGTH: 80 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...80 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:80 8 \QAjN- APNUS b Ut.U 1996 671 t Met Asn Tyr Gin Gin Lys LysPhe Phe Ser Gin Ser Leu Leu Ala 10 Ala Val Ser Gly Met Asp Gly Asn Gly Val 25 Leu Gin Giy Gin Ala Gin Met His Ala Asp 40 Ala Thr Asn Ala Thr Ilie Lys Gly Phe Asp 55 Phe Phe Phe Glu Lys His Phe Gly Leu Arg 70 75 Ile Leu Asn Leu Tyr Ile Giy Ser Leu Gly Met Giy Lys Tyr Phe INFORMATION FOR SEQ ID NO:809: SEQUENCE CHARACTERISTICS: LENGTH: 447 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyiori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .447 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:809 Met 1 Val Lys Ile Phe Ser Asn Arg Met Ile 145 Giu Lys Leu Tyr Ilie 225 Leu Asp Leu Arg Leu Leu Val 130 Ile Arg Thr Lys Asp 210 Lev Lys Leu Ile Asp Phe Leu Asp Thr 115 Leu Ser Tyr Ala Giu 195 Pro Arg Lys Ile Phe Tyr Gly Phe Ile Val Leu Phe Leu Ile Ile Leu Ala Arg Tyr Ala Ala 100 Glu Thr Ile Leu Ser 180 Ile Thr Arg 5 Ala Lys Lys Ala Val1 Val Giy Arg Arg Asn 165 Leu Thr Lys Leu Val Ile Gly Arg 70 Giu Met Gly Giu Ile 150 Gin Gly Met Asn Tyr 230 Leu Lys Arg 55 Phe Asp Arg Ser Lys 135 Giu Thr Tyr Leu Leu 215 Ser Val2 Asp 40 Leu Giu Thr Aia Thr 120 Thr Lys Phe Phe Val1 200 Giu Leu 25 ryr I le Gliu Leu Met 105 Leu Leu Val1 Phe Lys 185 Ala Phe Gly Gin Val Arg Pro Ala Asn Ile Pro 75 Phe Phe 90 Ile Lys Thr Gin Thr Arg Leu Ser 155 Gly His 170 Lys Pro Leu Pro Ser Leu Unk Ile 235 rrp Ser Ile Pro G iu Asn Gin Lys 140 Lys Giy Leu Arg Ser 220 Ser Val Val Tyr Arg His Ala Leu 125 Leu Giu Tyr Asp Ala 205 Arg Ser Thr Ala Asp Phe Gly Lys 110 Val Lys Giu Tyr Lys 190 Prc Ala Asr Thr2 Ser Lys Val Gly Ser Lys Giu Ile Gly 175 Leu Ser Asn Giu ksp .ln 31u Glu Ile Gly Asn Ala Leu 160 Vai Thr Phe Asp Leu Lys Ser Ala Leu Asn 245 Giu Val Pro 114 Val1 250 Tyr Asn Gin Thr Ser Thr 255 PCT/IS 96/O91a2.
IPENUS 18 LJ 1996 Gin Asn Ile-Ala Pro Tyr 260 Gin Asp Gin 305 Ser Giu Lys Ser Ser 385 Asn Tyr His Leu Leu 290 Lys Asn Thr Lys Ala 370 Thr Unk Ser Asp 275 Asp Ile Asp Ser Ser 355 Ile Thr Ser Arg Leu 435 Giy Tyr Leu Lys Thr 340 Aia Lys Ser Lys Lys 420 As n Leu Gin Giu Asp 325 Giy Phe Pro Lys Asn 405 Phe Leu Lys Arg Lys 310 Giu Lys Asn Phe Ile 390 Ser Leu Ala Vai Vai Asp 265 Thr Gin Giy 280 Leu Aia Leu 295 Ile Aia Lys Asp Asn Leu Ile Leu Aia 345 Arg Aia Thr 360 Vai Tyr Gin 375 Pro Asp Thr Vai Gin Asn Giy Leu Vai 425 Thr Ile Asn 440 Giu Tyr Giu Giu Asn 330 Leu Gin Ile Aia His 4i0 Thr Leu Vali Thr Ser Lys 315 Aia Vali Aia Aia Arg 395 Aia Leu Ala Lys Lys 285 Arg Lys Met Giy Arg 365 Asp Phe His Giu Aia 445 Gin 270 Leu Phe Thr Ile Ile 350 Gin Asn Giu Pro Aia 430 Trp Leu Thr Giy Asn Vali 335 Asp Phe Giy Asn Ser 415 Leu Leu Asp Ile His Aia 320 Thr Tyr Giy Tyr Giy 400 Asn Ser INFORMATION FOR SEQ ID, SEQUENCE CHARACTERISTICS: LENGTH: 218 amino acids TYPE: amino acid TOPOLOGY: iinear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Heiicobacter pyiori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .218 (xi).SEQUENCE DESCRIPTION: SEQ ID Met Asn Asp Thr Thr Giu His His Giy Ser Asn Pro Leu Asn Pro Leu Lys Pro Gin Giy Phe Vali ~Phe Pro Ser TIyr Pro Asn Gin s0 Gin Giu Arg Ilie Leu Giu Aia Ile 115 Giu Ser 130 Giy Vai Asn Lys Giu Lys Met His 100 Tyr Leu Giy Ser Gin Giy Ser Giu Leu Arg Tyr 70 Giu Aia Leu Leu Phe Vai Lys Thr Ala Val Ser Leu Lys 55 G iu Tyr Giy Phe Lys 135 Leu Asn G iy 40 Asn Leu Ala Leu Leu 120 Leu Phe 10 Asp Leu 25 Giu Gin Ile Leu Leu Met His Ser 90 Cys Met 105 Arg Thr Lys Leu Phe Giy Leu Arg Ile Gin 75 Phe Giy Ser Gin Leu Asn Phe G iu Ile Leu Giy Lys Tyr i4 0 Giu Leu His Ile Giy Giy Ile Asn 125 Phe Thr Leu G iu Giu Gin Tyr Phe Thr Tyr Ile Aia Asp Aia Lys Aia Ile Vali Giu Tyr Arg Pro Ser Leu Leu Lys Gly Leu Leu Aia Ser
~'"ET
IPEAUS 18 DEC1996 673 145 150 155 160 Ile Tyr Glu Leu Tyr Ile Leu Gly Ile Gly Ser Thr Asn Asp Lys Val 165 170 175 Leu Phe Val Leu Lys Asn Ile Cys Phe Ile Gly Met Gly Tyr Leu Ile 180 185 190 Tyr Lys Val Ile Lys Val Ile Gly Ile Lys Asn Phe Ile Asn Gly Leu 195 200 205 Phe Ala Ser Lys Lys Gin Gly Gly Ala Glu 210 215 INFORMATION FOR SEQ ID NO:811: SEQUENCE CHARACTERISTICS: LENGTH: 192 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .192 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:811 Met Met Asp Lys Val Gly Phe Lys Ser Gin Gly Ile Phe Val Met Asp 1 5 10 Ala Ser Lys Arg Asp Gly Arg Leu Asn Ala Tyr Phe Gly Gly Leu Gly 25 Lys Asn Lys Arg Val Val Leu Phe Asp Thr Leu Ile Ser Lys Val Gly 40 Thr Glu Unk Leu Leu Ala Ile Leu Gly His Glu Leu Gly His Phe Lys 55 Asn Lys Asp Leu Leu Lys Asn Leu Gly Ile Met Gly Gly Leu Leu Ala 70 75 Leu .Val Phe Ala Leu Ile Ala His Leu Pro Pro Leu Val Phe Glu Gly 90 Phe Asn Val Ser Gln Thr Pro Ala Ser Leu Ile Thr Ile Leu Leu Leu 100 105 110 Phe Leu Pro Val Phe Ser Phe Tyr Ala Met Pro Leu Ii Gly Phe Phe 115 120 125 Ser Arg Lys Asn Glu Tyr Asn Ala Asp Lys Phe Gly Ala Ser Leu Ser 130 135 140 Ser Lys Glu Thr Leu Ala Lys Ala Leu Val Ser Ile Val Asn Glu Asn 145 150 155 160 Lys Ala Phe Pro Tyr Ser His Pro Phe Tyr Val Phe Leu His Phe Thr 165 170 175 His Pro Pro Leu Leu Glu Arg Leu Lys Ala Leu Asp Tyr Glu Ile Glu 180 185 190 INFORMATION FOR SEQ ID NO:812: SEQUENCE CHARACTERISTICS: LENGTH: 340 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein PCT/US q6/091 22 IPEA/US 1 DE0 1996 (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...340 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:812 Met Ile Leu Ser Ile Glu Ser Ser Cys Asp Asp Ser Ser Leu Ala Leu 1 Thr Glu Arg Ser Gin Ala Arg Pro Ala 145 Ser Tyr Pro Leu Glu 225 Tyr Arg Ala Glu Asn 305 Arg Lys Arg Lys Leu Leu Pro Leu Gly Leu 130 Arg Phe Pro Asn Ala 210 Lys His Tyr Ser Phe 290 Ala Phe Asn 5 Ile Glu Asp His His Ser His Ala Glu Asn Lys Asp Gly Leu Ser Ser Leu Ser 100 His Val Tyr 115 Ser Val Leu Asp Tyr Glu Gly Glu Ser 165 Gly Gly Pro 180 Glu Pro Leu 195 Phe Ser Phe Asn Ala His Phe Gln Ser 245 Phe Lys Ile 260 Gin Asn Leu 275 Asp Cys Glu Ala Met Ile Ile Pro Leu 325 Phe Glu 340 Ala Lys Ser Tyr Asn Leu 55 Phe Ser 70 Val Thr Leu Asn Ser Leu Leu Val 135 Asp Ile 150 Phe Asp Ile Val Met Phe Ser Gly 215 Asn Leu 230 Ala Ala Lys Arg Ala Leu Leu Val 295 Gly Arg 310 Leu Gly 40 Pro Lys Leu Leu Phe 120 Ser Lys Lys Glu Pro 200 Leu Asn Ile Pro Arg 280 Leu Ser Ile 25 Gly Leu Ile Ile Pro 105 Ile Gly Ile Val Lys 185 Ile Lys Asp Glu Lys 265 Lys Ala Ser 10 Ala I Val Leu I Lys 2 Glu 90 Leu Asn Gly Val Ser 170 Leu Pro Asn Glu His 250 Ile Ala Pro Leu Ile 330 His Val Leu Ala 75 Gly Ile Glu His Ala 155 Lys Ala Leu Ala Val 235 Leu Phe Phe Leu Glu 315 Ser Phe Pro Glu Ile Leu Leu Lys Ser 140 Thr Met Leu Lys Val 220 Lys Ile Gly Glu Glu 300 Ala Pro Lys Glu Arg Ala Met Glu Gin 125 Leu Ser Leu Asp Asn 205 Arg Gin Gin Ile Asp 285 Phe Tyr Arg Ile Ile Val Ile Met Asp 110 Thr Ile Leu Asp Tyr 190 Ser Leu Lys Gin Val 270 Leu Cys Gir Thi Ser C Ala Lys Thr 2 Ala I His I Arg Leu Asp Leu 175 Ala Pro Glu Ile Thr 255 Gly Cys Ser Lys Leu 335 ln Ser Ile Asn Lys Leu 4et 3lu Asp 160 Gly His Asn Val Gly 240 Lys Gly Ala Asp Lys 320 Leu Glu Lys Ala Asp INFORMATION FOR SEQ ID NO:812: SEQUENCE CHARACTERISTICS: LENGTH: 340 amino acids TYPE: amino acid TOPOLOGY: linear tiCT/US 9 6/0912 2 1PEA/U S 18 0 E U 199 96 675 (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM:. Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .340 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:812 Met Ile Leu Ser Ile Giu Ser Ser Cys Asp Asp Ser Sen Leu Ala Leu 1 Thr G1.u Arg Sen Gin Ala Arg Pro Ala 145 Sen Tyr Pro Leu Glu 225 Tyr Arg Ala Giu Asn 305 Arg Lys Arg Lys Leu Leu Pro Leu Gly Leu 130 Arg Phe Pro Asn Ala 210 Lys His Sen Phe 290 Ala Phe Asn Ile His His As n Gly Ser His 115 Ser Asp Gly Gly Glu 195 Phe Asn Phe Phe Gin 27.5 Asp Ala Ile Phe 5 Giu Asp His Ser Ala Giu Lys Asp Leu Ser Leu Ser 100 Val Tyr Val Leu Tyr Giu Glu Sen 165 Gly Pro 180 Pro Leu Sen Phe Ala His Gin Ser 245 Lys Ilie 260 Asn Leu Cys Giu Met Ile Pro Leu 325 Glu 340 klia Ser %s n Phe 70 Val1 Leu Ser Leu Asp 150 Phe Ile Met Ser Asn 230 Ala Lys Ala Leu G ly 310 Lys Tyr Leu 55 Sen Thr Asn Leu Val1 135 Ile Asp Val1 Phe Gly 215 Leu Ala Arg Leu *Val 295 *Arg Leu Gly 40 Pro Lys Leu Leu ?he 120 Ser rEqs Lys Giu Pro 200 Leu Asn Ile Pro Arg 280 Leu Sen Ile 25 Gly Leu Ile Ile Pro 105 Ile G ly Ile Val1 Lys 185 Ile Lys Asp Giu Lys 265 Lys Ala Ser AlaI Val Leu Lys Giu 90 Leu Asn Gly' Val Ser 170 Leu Pro Asn Glu His 250 Ile Ala Pro Leu Sle 330 *iis la 1 Leu kla 75 Gly Ile Glu His Ala 155 Lys Ala Leu Ala Val 235 Leu Phe Phe Leu G lu 315 Phe Pro Giu Ile Leu Leu Lys Ser 140 Thr Met Leu Lys Val1 220 Lys Ile Gly Glu Giu 300 Ala Lys Giu Arg Ala Met Giu Gln 125 Leu Ser Leu Asp Asn 205 Arg Gln Gin Ile Asp 285 Phe Tyr Ile Ile Val Ile M4et Asp 110 Thr Ile Leu Asp Tyr 190 Sen Leu Lys Gin Val 270 Leu Cys Gin Ser Ala Lys rhr Ala His Ang Leu Asp Leu 175 Ala Pro G iu Ile Thr 255 Gly Cys Ser Lys Gln Sen Ile Asn Lys Leu Met Giu Asp 160 Gly His Asn Val1 Gly 240 Lys *Gly Ala *Asp *Lys 320 Giu Lys Ala AsE Ser Pro Arg Thr Leu Leu 335 INFORMATION FOR SEQ ID NO:813: SEQUENCE CHARACTERISTICS: LENGTH: 201 amino acids TYPE: amino acid TOPOLOGY: linear P6 1 091 2 2 676PENUS 18 0EC 1996 (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...201 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:813 Met Asn Ile Tyr Gln Lys Asn Leu Gin Ala Leu Phe Lys Lys Asp Pro 1 5 10 Leu Leu Phe Ala Lys Leu Lys Ala Ile Lys Glu Asn Lys Lys Tyr Glu 25 Val Phe Leu Gly Asn Asp Ser Ala Asn Phe Asn Leu Leu Asp Lys Glu 40 Thr Asn Thr Pro Leu Phe Glu Lys Ser Pro Leu Asp Ser Ser Leu Glu 55 Leu Tyr Lys Asn Ser Glu Ile His Met Leu Tyr Pro Tyr Leu Tyr Tyr 70 75 Phe Gly Leu Gly Asn Gly Val Phe Tyr Arg Leu Leu Leu Gly Asn Glu 90 Asn Leu Lys Arg Leu Val Val Ile Glu Pro Glu Ile Glu Val Ile Phe 100 105 110 Ile Val Leu Asn Leu Leu Asp Phe Ser Thr Glu Ile Leu Glu Asn Arg 115 120 125 Leu Ile Leu Leu His Ala Ser Phe Cys Asn Tyr Asn Met Ile Ala Ser 130 135 140 Leu Phe Asp Met Asp Lys Lys Ser Arg Leu Tyr Ala Arg Met Tyr Asp 145 150 155 160 Leu Lys Leu Phe Asn Ala Tyr Tyr Glu Arg Tyr Ser His Gin Met Ile 165 170 175 Glu Ile Asn Gln His Phe Thr Arg Ala Leu Glu His Gly Ala Ile Ser 180 185 190 Val Gly Asn Asp Ala Lys Ala His Ser 195 200 INFORMATION FOR SEQ ID NO:814: .SEQUENCE
CHARACTERISTICS:
LENGTH: 130 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...130 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:814 Met Lys Lys Ile Ile Leu Ala Cys Leu Val Ala Phe Val Gly Ala Asn 1 5 0 Ala Gu Pro Lys Trp Tyr Ser Lys Ala Tyr Asn Lys Thr Asn A Leu Ser Ala Glu Pro Lys Trp Tyr Ser Lys Ala Tyr Asn Lys Thr Asn ES 196/DE091 2996 Ha is Dl.Ll; i996 Ala Ala Val Leu Glu Tyr Lys Lys" Gly Lys Gin Asn Ser Ser Ser Asn Asn 100 Thr Arg 115 Tyr Lys Gin Asp Val Val Ser Val Ser Leu Glu Leu Thr Ser Val Thr Gin Phe 125 INFORMATION FOR SEQ ID NO:815: SEQUENCE CHARACTERISTICS: LENGTH: 144 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...144 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:815 Met Lys Ile Gln Thr Ile Ser Thr Leu Val Leu Thr Ile Ile Met Val 1 Ile Glu Ser Pro Asn Gin Val Asp Gin Phe Trp Thr Gly Asp Leu Gly 130 Lys Thr Gly Asp Leu Ile Lys 115 Glu 5 Ile Leu Ala Asp Asn Asn Ser Gly Val Met Ile Asn 70 Ser Lys Gly Thr Gly Leu Leu 55 Asp Lys Phe Val Leu 135 Lys Asn 40 Asn Pro Val Lys Val 120 Gly Ile Met Ala Ser Asp Asn 105 Gly Val 10 Ser Pro Ile Ala Pro Phe Lys Cys 75 Gin Lys 90 Lys Ala Unk Unk Unk Ala His Val Glu Val Tyr Asp Asn Tyr 140 Lys Leu Phe Asn Val Leu Gly 125 Ala Thr Asp Thr Pro Leu Asp 110 Tyr Leu Ala Ser Asn Gly Asn Val Gly Gly Glu Gin Ser Thr Lys Ile Asn Ser INFORMATION FOR SEQ ID NO:816: SEQUENCE CHARACTERISTICS: LENGTH: 309 amino acids TYPE: amino acid TOPOLOGY: linear I 7(ii) MOLECULE TYPE: protein NATC~ PU 1 9 6 0 91 2 2 PEA/US 18 DEC1996 678 (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori
FEATURE:
NAME/KEY: misc_feature LOCATION 1...309 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:816 Val Val Ile Arg Leu Val Leu Asn Met Leu Thr Cys Gln Ile Ser Tyr 1 5 10 Ile Arg Ile Ser Tyr Leu Val Ser Val Ser Asp Phe Val Ile Cys Lys 25 Glu Arg Phe Met Asp Glu Ile Lys Thr Leu Leu Val Asp Phe Phe Pro 40 Gin Ala Lys His Phe Gly Ile Ile Leu Ile Lys Ala Ile Val Val Phe 55 Cys Ile Gly Phe Tyr Phe Ser Phe Phe Leu Arg Asn Lys Thr Met Lys 70 75 Leu Leu Ser Lys Lys Asp Glu Ile Leu Ala Asn Phe Val Ala Gln Val 90 Thr Phe Ile Leu Ile Leu Ile Ile Thr Thr Ile Ile Ala Leu Ser Thr 100 105 110 Leu Gly Val Gln Thr Thr Ser Ile Ile Thr Val Leu Gly Thr Val Gly 115 120 125 Ile Ala Val Ala Leu Ala Leu Lys Asp Tyr Leu Ser Ser Ile Ala Gly 130 135 140 Gly Ile Ile Leu Ile Ile Leu His Pro Phe Lys Lys Gly Asp Ile Ile 145 150 155 160 Glu Ile Ser Gly Leu Glu Gly Lys Val Glu Ala Leu Asn Phe Phe Asn 165 170 175 Thr Ser Leu Arg Leu His Asp Gly Arg Leu Ala Val Leu Pro Asn ?rg 180 185 190 Ser Val Ala Asn Ser Asn Ile Ile Asn Ser Asn Asn Thr Ala Cys Arg 195 200 205 Arg Ile Glu Trp Val Cys Gly Val Gly Tyr Gly Ser Asp Ile Glu Leu 210 215 220 Val His Lys Thr Ile Lys Asp Val Ile Asp Gly Met Glu Lys Ile Asp 225 230 235 240 Lys Asn Met Pro Thr Phe Ile Gly Ile Thr Asp Phe Gly Gln Ser Ser 245 250 255 Leu Asn Phe Thr Ile Arg Val Trp Ala Lys Ile Glu Asp Gly Ile Phe 260 265 270 Asn Val Arg Ser Glu Leu Ile Glu Arg Ile Lys Asn Ala Leu Asp Ala 275 280 285 Asn Arg Ile Glu Ile Pro Phe Asn Lys Leu Asp Ile Ser Ile Asn Lys 290 295 300 Gin Asp Ser Ser Lys 305 INFORMATION FOR SEQ ID NO:817: SEQUENCE CHARACTERISTICS: LENGTH: 164 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
-M -qq- PCT/US 96/091 2 679 IPEAUS 18 DEC 1996 (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...164 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:817 Met Lys Asn Phe Ser Pro Leu Tyr Cys Leu Lys Unk Leu Lys Lys Arg 1 5 10 His Leu Ile Ala Leu Ser Leu Pro Leu Leu Ser Tyr Ala Asn Gly Phe 25 Lys Ile Gin Glu Gin Ser Leu Asn Gly Thr Ala Leu Gly Ser Ala Tyr 40 Val Ala Gly Ala Arg Gly Ala Asp Ala Ser Phe Tyr Asn Pro Ala Asn 55 Met Gly Phe Thr Asn Asp Trp Gly Glu Asn Arg Ser Glu Phe GIu Met 70 75 Thr Thr Thr Val Ile Asn Ile Pro Thr Phe Ser Phe Lys Val Pro Thr 90 Thr Asn Gin Unk Leu Tyr Ser Val Thr Ser Leu Glu Ile Asp Lys Ser 100 105 110 Gin Gin Asn Ile Leu Gly Ile Ile Asn Thr Ile Gly Leu Gly Asn Ile 115 120 125 Leu Lys Ala Leu Gly Asn Thr Ala Ala Thr Asn Gly Leu Ser Gin Ala 130 135 140 Ile Asn Arg Val Gln Gly Leu Met Asn Leu Thr Asn Gin Lys Val Val 145 150 155 160 Thr Leu Ala Ser INFORMATION FOR SEQ ID NO:818: SEQUENCE CHARACTERISTICS: LENGTH: 54 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...54 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:818 Met Cys Leu Ala Ile Pro Ser Lys Val Ile Ala Ile Asn Asp Asn Val 1 5 10 Ala Leu Leu Glu Thr Leu Gly Val Gin Arg Glu Ala Ser Leu Asp Leu 25 Met Gly Glu Ser Val Lys Val Gly Asp Tyr Val Leu Leu His Ile Gly 40 Tyr Val Met Ser Lys Asp INFORMATION FOR SEQ ID NO:819: PCT/US 96/091 22 680 IPEA/S18 DEC1996 SEQUENCE CHARACTERISTICS: LENGTH: 202 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...202 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:819 Met Lys Tyr Leu Trp Leu Phe Leu Ile Tyr Ala Ile Gly Leu Phe Ala 1 5 10 Thr Asp Lys Thr Leu Asp Ile Ile Lys Thr Ile Gin Lys Leu Pro Lys 25 Ile Glu Val Arg Tyr Ser Ile Asp Asn Asp Ala Asn Tyr Ala Leu Lys 40 Leu His Glu Val Leu Ala Asn Asp Leu Lys Thr Ser Gln His Phe Asp 55 Val Ser Gin Asn Lys Glu Gin Gly Ala Ile Asn Tyr Ala Glu Leu Lys 70 75 Asp Lys Lys Val His Leu Val Ala Leu Val Ser Val Ala Val Glu Asn 90 Gly Asn Lys Ile Ser Arg Leu Lys Leu Tyr Asp Val Asp Thr Gly Thr 100 105 110 Leu Lys Lys Thr Phe Asp Tyr Pro Ile Val Ser Leu Asp Leu Tyr Pro 115 120 125 Phe Ala Ala His Asn Met Ala Ile Val Val Asn Asp Tyr Leu Lys Ala 130 135 140 Pro Ser Ile Ala Trp Met Lys Arg Leu Ile Val Phe Ser Lys Tyr Ile 145 150 155 160 Gly Pro Gly Ile Thr Asn Ile Ala Leu Ala Asn Tyr Thr Met Arg Tyr 165 170 175 Gin Lys Glu Ile Ile Lys Asn Asn Arg Leu Asn Ile Phe Pro Lys Trp 180 185 190 Ala Asn Ala Glu Gln Thr Glu Phe Tyr Tyr 195 200 INFORMATION FOR SEQ ID NO:820: SEQUENCE CHARACTERISTICS: LENGTH: 168 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...168 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:820 PTIJ 9 6 /09122 -AJUS 18 DEC 1996 681.
Met Leu Phe Gin Leu Lys Ser Lys Thr Ser 145 Leu Leu Ser Val Leu Tyr His Giu Asn Giu Giy Thr Thr Met Asp Thr Unk 115 Giu Lys 130 Ile Ser Asn Met Ser Val1 Lys Tyr Leu Leu Lys 100 Unk Gin Lys Ala Met Tyr Giu Arg Ser As n Leu 105 Ile Tyr Ser Val1 Leu Lys Leu Ala Gin Giu Met Gin Lys Leu Glu Tyr Arg Leu Lys Unk Ser Asp Ile 160 INFORMATION FOR SEQ ID NO:820: SEQUENCE CHARACTERISTICS: LENGTH: 168 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .168 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:820 Met Leu Ser Ser Asn Asp Leu Phe Met Val Vai Leu Gly Ala Ile Leu 1 Leu Phe Gin Leu Lys Ser Lys Thr Ser 145 Vai Giu Giu Thr Met Thr Glu 130 Ile Leu His Asn Gly Thr Asp Unk 115 Lys Ser Val1 Lys Tyr Leu Leu Lys 100 Unk Gin Lys 5 Cys Met Leu Sen Sen Giu Lys Val1 Giu Leu Arg Tyr Leu 70 His Arg Thr Leu Phe 150 Vali Arg Ser Giu Leu Asp Trp Lys 135 Lys Gly Leu 40 Lys Lys Tyr Tyr Giy 120 Met Val1 Tyr 25 Giu Arg Ser Asn Leu 105 Ile Tyr Ser Leu Lys Leu Ala Gin 90 Giu Met Gin Lys Tyr Thr Arg Lys 75 Leu Giu Pro G iu Gly 155 Leu Leu Giu Giu Gin Lys Leu Gly 140 Glu Lys Asp Leu Asp Giu Ile Ala 125 Tyr Val1 Giu Lys Giu Scr Giu Gly Sen Sen Ile Gin Ile Unk 110 Met Lys Ser Vai Giu Phe Giu Tyr Ang Leu Lys Unk Sen Asp Ile 160 PCT/US 96/09122 IPfANUS i LJEC 1996 Leu Asn Met Ala Gly Leu Lys Trp 165 INFORMATION FOR SEQ ID NO:821: SEQUENCE CHARACTERISTICS: LENGTH: 186 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...186 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:821 Val Val Ser Gly Val Val Ile Ile Ile Val Phe Phe 1 Thr lie Pro Phe Phe Ile Ala Ile Ile 145 Ser Phe Leu Val Val Leu Val Ala Leu Ser 130 Lys Asp Ile Gin Tyr Val Thr His Ser Asp 115 Leu Lys Glu Ser Gly Ala Ser Arg Asn Leu 100 Glu Asp His Leu Phe 180 5 Leu Leu Ser Phe Pro Ser Gly Gin Val Gly 165 Ile Glu Leu Leu Leu 70 Lys Leu Asp Ser Lys 150 Leu Pro Gly Gly Val 55 Asn Lys Phe Val Lys 135 Glu Asp Lys Lys Thr 40 Leu Arg Val Pro Val 120 Asp Val Leu Lys 10 Met Phe 25 Leu Val Lys Ala Ile Tyr Ile Leu 90 Phe Val 105 Leu Ser Leu Met Lys Ser Gly Gly 170 Glu Trp 185 Arg Leu Thr Ala 75 Gly Gly Val Leu Ile 155 Leu Pro Ser Pro Pro Ala Lys Glu Asn 140 Val Asn Val Leu Ile His Leu Phe Asn Thr 125 Ile Ala Gin Pro Ala Thr Ser Leu Val Phe 110 Thr Glu Arg Thr Ile Leu Gin Ser Ile Ile Glu Thr Glu Phe Phe Leu Met Pro Pro Ser Ser Ala Thr Gly 160 Asp Thr 175 INFORMATION FOR SEQ ID NO:822: SEQUENCE CHARACTERISTICS: LENGTH: 72 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: -o" IR 7 ftl ~t-l- PCT/US 96/091 683, PE US 18 DEC 1996 NAME/KEY: misc_feature LOCATION .72 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:822 Val Gly Tyr Ile Pro Unk Glu Lys Ile Val Gly Ile Ser Ala Ile Ala 1 5 10 Lys Leu Ile Glu Ile Tyr Ser Lys Arg Leu Gin Ile Gin Glu Arg Leu 25 Thr Thr Gln Ile Ala Glu Thr Phe Asp Glu Ile Ile Glu Pro Arg Gly 40 Val Ile Val Val Cys Glu Ala Lys Pro Leu Val His Glu His Ala Arg 55 Gly Ala Lys Ala Lys Cys Asp His INFORMATION FOR SEQ ID NO:823: SEQUENCE CHARACTERISTICS: LENGTH: 121 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...121 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:823 Leu Asp Pro Phe Ser His Lys Glu Asn Phe Leu Ala Val Glu Thr Phe 1 5 10 Lys Met Leu Gly Lys Thr Glu Ser Lys Asp Asn Leu Asn Trp Met Ile 25 Ala Leu Ile Ile Glu Lys Asp Lys Val Tyr Glu Gln Val Gly Ser Val 40 Arg Phe Val Val Val Val Ala Ser Ala Ile Met Val Leu Ala Leu Ile 55 Ile Ala Ile Thr Leu Leu Met Arg Ala Ile Val Ser Asn Arg Leu Glu 70 75 Val Val Ser Ser Thr Leu Ser His Phe Phe Lys Leu Leu Asn Asn Gin 90 Unk His Ser Ser Unk Unk Lys Leu Val Unk Ala Arg Ser Asn Asp Glu 100 105 110 Leu Gly Arg Unk Gin Thr Unk Asp Unk 115 120 INFORMATION FOR SEQ ID NO:823: SEQUENCE CHARACTERISTICS: LENGTH: 121 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein S(iii) HYPOTHETICAL: YES PCT/US 9 6 0 9122 684 IPENA/US 18 DEC 1996 (vi) OR-IGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION 1...121 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:823 Leu Asp Pro Phe Ser His Lys Glu Asn Phe Leu Ala Val Glu Thr Phe 1 5 10 Lys Met Leu Gly Lys Thr Glu Ser Lys Asp Asn Leu Asn Trp Met Ile 25 Ala Leu Ile Ile Glu Lys Asp Lys Val Tyr Glu Gln Val Gly Ser Val 40 Arg Phe Val Val Val Val Ala Ser Ala Ile Met Val Leu Ala Leu Ile 55 Ile Ala Ile Thr Leu Leu Met Arg Ala Ile Val Ser Asn Arg Leu Glu 70 75 Val Val Ser Ser Thr Leu Ser His Phe Phe Lys Leu Leu Asn Asn Gin 90 Unk His Ser Ser Unk Unk Lys Leu Val Unk Ala Arg Ser Asn Asp Glu 100 105 110 Leu Gly Arg Unk Gln Thr Unk Asp Unk 115 120 INFORMATION FOR SEQ ID NO:824: SEQUENCE CHARACTERISTICS: LENGTH: 13 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...13 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:824 Val Ala Leu Val Phe Asp Ser Leu Ile Glu Asn Lys Lys 1 5 INFORMATION FOR SEQ ID NO:825: SEQUENCE CHARACTERISTICS: LENGTH: 99 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori K 'Vr QY PCT/US 9 6 0 91 22 iPEAUS 1bULU1996 685 (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...99 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:825 Met Lys Lys Ile Gly Leu Ser Leu Cys Leu Val Leu Ser Leu Gly Phe 1 5 10 Leu Lys Ala His Glu Val Ser Ala Glu Glu Ile Ala Asp Ile Phe Tyr 25 Lys Leu Asn Ala Lys Glu Pro Lys Met Lys Ile Asn His Thr Lys Gly 40 Phe Cys Ala Lys Gly Val Phe Leu Pro Asn Pro Gin Ala Arg Glu Asp 55 Leu Glu Val Pro Leu Leu Asn Glu Lys Glu Ile Pro Ala Ser Val Arg 70 75 Tyr Ser Leu Gly Gly Val Val Asp Trp Thr Ile Lys Ala Arg Leu Gly 90 Glu Trp Arg INFORMATION FOR SEQ ID NO:826: SEQUENCE CHARACTERISTICS: LENGTH: 71 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...71 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:826 Val Ile Lys Pro His Ser Val Gly Leu Val Arg Ile Gly Ile Cys Leu 1 5 10 Ser Leu Glu Val Gly Tyr Glu Leu Gln Val Arg Thr Arg Ser Gly Leu 25 Ala Leu Asn His Gin Val Met Val Leu Asn Unk Pro Gly Thr Val Asp 40 Asn Asp Tyr Arg Gly Glu Ile Lys Val Ile Leu Ala Asn Leu Ser Asp 55 Lys Asp Phe Lys Val Gin Val INFORMATION FOR SEQ ID NO:827: SEQUENCE CHARACTERISTICS: LENGTH: 149 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES .jj PCV 94 91 2? IPENUS 18 0EC 1996 686 (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...149 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:827 Met Glu Phe Tyr Gin Val Tyr Asp Pro Leu Gly His Ile Trp Leu Ser 1 5 10 Ala Leu Val Ala Leu Ser Pro Ile Ala Leu Phe Phe Ile Ser Leu Ile 25 Val Phe Lys Leu Lys Gly Tyr Ser Ala Gly Phe Leu Ser Leu Ala Leu 40 Ser Ile Leu Ile Ala Leu Phe Val Tyr Lys Met Pro Val Gin Met Val 55 Ser Ala Ser Phe Phe Tyr Gly Phe Leu Tyr Gly Leu Trp Pro Ile Ala 70 75 Trp Ile Val Ile Ala Ala Ile Phe Leu Tyr Asn Leu Ser Val Lys Ser 90 Gly Tyr Phe Glu Ile Leu Lys Glu Ser Ile Leu Ser Leu Thr Pro Asp 100 105 110 His Arg Ile Leu Val Ile Leu Ile Gly Phe Cys Phe Gly Ser Phe Leu 115 120 125 Unk Gly Ala Unk Gly Phe Gly Gly Pro Val Ala Ile Thr Ala Ala Ile 130 135 140 Leu Val Ala Leu Gly 145 INFORMATION FOR SEQ ID NO:827: SEQUENCE CHARACTERISTICS: LENGTH: 149 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein.
(iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...149 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:827 Met Glu Phe Tyr Gin Val Tyr Asp Pro Leu Gly His Ile Trp Leu Ser 1 5 10 Ala Leu Val Ala Leu Ser Pro Ile Ala Leu Phe Phe Ile Ser Leu Ile 25 Val Phe Lys Leu Lys Gly Tyr Ser Ala Gly Phe Leu Ser Leu Ala Leu 40 Ser Ile Leu Ile Ala Leu Phe Val Tyr Lys Met Pro Val Gin Met Val 55 Ser Ala Ser Phe Phe Tyr Gly Phe Leu Tyr Gly Leu Trp Pro Ile Ala 70 75 N Trp Ile Val Ile Ala Ala Ile Phe Leu Tyr Asn Leu Ser Val Lys Ser 90 Gly Tyr Phe Glu Ile Leu Lys Glu Ser Ile Leu Ser Leu Thr Pro Asp *y PCT/US 96/091 22 IPEA/US 1l uU 6 687 100 105 110 His Arg Ile Leu Val lie Leu Ile Gly Phe Cys Phe Gly Ser Phe Leu 115 120 125 Unk Gly Ala Unk Gly Phe Gly Gly Pro Val Ala Ile Thr Ala Ala Ile 130 135 140 Leu Val Ala Leu Gly 145 INFORMATION FOR SEQ ID NO:828: SEQUENCE CHARACTERISTICS: LENGTH: 255 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...255 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:828 Met Glu Ile lie Leu Leu Ile Val Ala Ala Val Val Leu Phe Tyr Phe 1 5 10 Tyr Asn Thr Leu Lys Glu Tyr Leu Lys Asn Pro Leu Asn Pro Lys Thr 25 Lys Thr Glu Glu Tyr Asp Leu Lys Asn Asp Pro Tyr Leu Leu Val Gin 40 Ser Ser Pro Leu Asp Lys Phe Lys Gln Thr Gln Ile Gly Ala Tyr Met 55 Arg Leu Leu Lys Phe Leu Asp Ile Gin Lys Asn Ala Leu Asp Asn Ala 70 75 Leu Arg Thr Leu Phe Ile His Glu Leu Glu Gin Pro Leu Asn Ser Glu 90 Gin Gln Asn Leu Ala Lys Glu Leu Leu Asn Glu Pro Val Asp Lys Lys 100 105 110 Glu Asn Phe Glu Ser Leu Cys Gln Glu Ile Ala Asp His Thr His Gly 115 120 125 Glu Tyr Thr Lys Arg Leu Lys Leu Val Glu Phe Leu Met Leu Leu Ala 130 135 140 Tyr Ala Asp Gly Ile Leu Asp Ser Lys Glu Lys Glu Leu Phe Leu Asp 145 150 155 160 Val Gly Ala Phe Leu Gin Ile Asp Asn Gln Asp Phe Asn Glu Leu Tyr 165 170 175 Asp Asn Phe Glu His Phe Asn Ser Ile Glu Ile Pro Met Ser Leu Glu 180 185 190 Glu Ala Lys Asn Leu Phe Glu Ile Gin Thr His Thr Thr Met Gln Asp 195 200 205 Leu Glu Lys Lys Ala Leu Asp Leu Ser Ala Pro Tyr Tyr His Lys Met 210 215 220 Asn Asp Asn Lys Arg Tyr Ser Giu Gln Asp Phe Ile Ser Leu Lys Lys 225 230 235 240 Ile Ala Leu Ala Ser Gln Leu Leu Glu Asn Asp Leu Lys Asp Ser 245 250 255 INFORMATION FOR SEQ ID NO:829: PCT/US 96/09122 IPE/US 18 DEC 1996 688 SEQUENCE CHARACTERISTICS: LENGTH: 106 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...106 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:829 Met Glu Val Glu His Gly Lys Ile Glu Thr Thr Leu Ser Leu Gly Ala 1 5 10 Ser His Leu Glu Val Ile Lys Met Met Leu Leu Glu Ser Leu Pro Ser 25 Leu Val Asn Asn Ile Thr Ile Thr Leu Ile Ser Leu Ile Gly Tyr Ser 40 Ala Lys Ala Gly Ala Leu Gly Ala Gly Gly Leu Gly Asp Leu Ala Ile 55 Arg Ile Gly Tyr Gln Ser Tyr Arg Gly Asp Val Leu Phe Tyr Ala Val 70 75 Val Val Ile Ile Val Leu Val Gln Ile Ile Gln Ser Ala Gly Asp Tyr 90 Val Val Lys Arg Leu Arg Lys Asn Lys Tyr 100 105 INFORMATION FOR SEQ ID NO:830: SEQUENCE CHARACTERISTICS: LENGTH: 527 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...527 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:830 Met Asn Glu Ile Asp Lys Ser Val Asp Ile Gly Phe Leu Arg Ile Leu 1 5 10 Asp Val Ile Lys Lys Val Lys Thr Pro Lys Gly Gly Ile Glu Val Leu 25 Arg Thr Leu Ile Asp Phe Thr Pro Lys Ile Glu Asn Ala Leu Asn Leu 40 Ala Thr Lys Ser His Lys Gly Gln Tyr Arg Lys Ser Gly Glu Pro Tyr 55 Ile Val His Pro Ile Cys Val Ala Ser Val Val Ala Phe Cys Gly Gly 70 75 Asp Glu Ala Met Val Cys Ala Ala Leu Leu His Asp Val Val Glu Asp 1,
T
i uiuS 96/09122 PENUS 18 DEC 1996 Thr Pro Cys Glu Ala Glu Thr 145 Val Leu Tyr Leu Ile 225 Asn Ser Ile Leu Tyr 305 Arg Ile Arg Trp Met 385 Asp Asp Gly Asp Gin 465 Val Lys Thr Asn Leu 115 Leu Gly 130 Phe Arg Val Lys Pro His Ala Pro 195 Glu Asp 210 Lys Glu Ala Phe His Ser Tyr Leu 275 Asp Leu 290 Lys Val Phe Lys His Thr Thr Phe 355 Lys Tyr 370 Arg Trp Pro Lys Ile Val Ala Ile 435 Lys Ala 450 Glu Leu Ile Pro Asn His Lys Ser 515 100 Val Val Lys Ile Asp 180 Ile Lys Tyr Ala Asp 260 Lys Leu Leu Asp Thr 340 Asp Lys Leu Glu Val 420 Ala Thr Arg Arg Leu 500 Met Ile Asp Ser Ile Ser 165 Lys Ala Ser Leu Ser 245 Phe Met Ala Gly Tyr 325 Ile Met Ala Gin Phe 405 Phe Leu Asp Ser Phe 485 Arg Ile Ala Ser Leu 150 Asp Gin Ser Phe His 230 Lys Lys Gin Ile Ile 310 Ile Phe His Gly Asn 390 Tyr Ser Asp Ala Gly 470 Ile Ile Asn Leu Gin 135 Ile Arg Val Arg Tyr 215 Lys Leu Leu Arg Arg 295 Ile Ala Asp Met Gly 375 Phe Glu Pro Phe Tyr 455 Asp Trp Gin Ile Thr 120 Asp Ser Leu Arg Leu 200 Tyr Asn Glu Val Lys 280 Ile His Leu Glu Gly 360 Val Lys Leu His Ala 440 Ile Val Met Arg Leu 520 105 Lys Pro Ala His Ile 185 Gly Ile Lys Lys Thr 265 Gly Leu Leu Pro Ser 345 Ala Asp Tyr Ala Gly 425 Tyr Asn Val Asp Arg 505 Ala Ile Arg Ile Asn 170 Ser Met Tyr Gin Lys 250 Arg Ala Leu Asn Lys 330 Ser Glu His His Lys 410 Asp Met Ser Lys Gin 490 Asn Thr 90 Glu Thr Ile Glu Arg Glu Thr Met Gin 155 Met Lys Ser Pro Ser 235 Leu Val Val Lys Phe 315 Glu Val Tyr Glu Asp 395 Asn Thr Val Lys Ile 475 Leu Arg Phe Phe Glu Val 140 Asp Leu Glu Ser Glu 220 Leu Phe Lys Asn Asn 300 Lys Asn Tyr Gly Glu 380 Ser Asp Tyr His Lys 460 Ile Lys Leu Phe Gly Ile 125 Val Pro Thr Thr Ile 205 Glu Leu Asp Arg Ile 285 Pro Pro Gly Glu Asn 365 His Asp Leu Thr Ser 445 Ala Lys Thr Lys Trp 525 Gin 110 Arg Ser Arg Leu Leu 190 Lys Tyr Leu Ser Pro 270 Asp Ile Ile Tyr Val 350 Ser His Leu Tyr Leu 430 Asp Leu Gly Ser Glu 510 Ala Asp Lys Ala Ala Asp 175 Ala Asn Lys Lys Gly 255 Tyr Glu Asp Val Lys 335 Gln Ala Glu Lys Arg 415 Pro Leu Leu Asp Lys 495 Ile Leu Val Glu Leu Leu 160 Ala Val Glu Asn Leu 240 Phe Ser Ile Cys Ser 320 Thr Ile His Gly Asn 400 Glu Val Gly Asn Lys 480 Ala Asp INFORMATION FOR SEQ ID NO:831: SEQUENCE CHARACTERISTICS: LENGTH: 124 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein PT/US 9 6 0 91 ZZ JPENAUS 18 EC1996 690 (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...124 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:831 Val Val Val Val Glu Asn Ile Lys Asp Ala Val Pro Leu Ala Gin Ser 1 5 10 Leu Ile Unk Gly Gly Ile Pro Ile Ile Glu Val Thr Leu Arg Ser Asn 25 Cys Ala Leu Glu Ala Ile Glu Leu Ile Ala Lys Asn Val Pro Lys Met 40 Arg Val Gly Ala Gly Thr Ile Leu Asn Leu Thr Gln Leu Glu Gln Ala 55 Gin Asn Arg Gly Ala Glu Phe Leu Ile Ser Pro Gly Leu Thr Ile Lys 70 75 Leu Leu Glu His Ala Lys Lys Lys Asp Met Pro Leu Ile Pro Gly Val 90 Ser Ser Ser Ser Glu Val Met Gln Ala Leu Glu Leu Gly Tyr Asn Ala 100 105 110 Leu Lys Phe Phe Pro Ala Glu Tyr Cys Gly Gly Arg 115 120 INFORMATION FOR SEQ ID NO:832: SEQUENCE CHARACTERISTICS: LENGTH: 110 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori
FEATURE:
NAME/KEY: misc_feature LOCATION 1...110 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:832 Val Glu Lys Ile Lys Pro Tyr Ala Pro Lys Asp Ser Pro Leu Ile Asp 1 5 10 Tyr Ser Ser Leu Val Arg Asn Val Gln Ser Thr Leu Lys Gly Thr Ser 25 Phe Glu Thr Leu Ile Asn Gly Val Trp Glu Ser Phe Glu Thr Lys Val 40 Leu Gly Glu Phe Asn Ala Tyr Asn Ile Ala Ser Ala Ile Leu Thr Ala 55 Lys His Leu Gly Leu Glu Thr Glu Arg Ile Lys Arg Leu Val Phe Glu 70 75 Leu Lys Pro Ile Asn His Arg Leu Gln Leu Leu Glu Ala Asn Gln Lys 90 Ile Ile Ile Asp Asp Asn Phe Asn Gly Asn Leu Lys Gly Met 100 105 110 x *^HP"T^P PGT/US 96/09122 IP Z8E01996 691 INFORMATION FOR SEQ ID NO:833: SEQUENCE CHARACTERISTICS: LENGTH: 325 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...325 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:833 Met Lys Arg Ile Leu Val Ser Leu Ala Val Leu Ser His Ser Ala His 1 5 10 Ala Val Lys Thr His Asn Leu Glu Arg Val Glu Ala Ser Gly Val Ala 25 Asn Asp Lys Glu Ala Pro Leu Ser Trp Arg Ser Lys Glu Val Arg Asn 40 Tyr Met Gly Ser Arg Thr Val Ile Ser Asn Lys Gln Leu Thr Lys Ser 55 Ala Asn Gln Ser Ile Glu Glu Ala Leu Gln Asn Val Pro Gly Val His 70 75 Ile Arg Asn Ser Thr Gly Ile Gly Ala Val Pro Ser Ile Ser Ile Arg 90 Gly Phe Gly Ala Gly Gly Pro Gly His Ser Asn Thr Gly Met Ile Leu 100 105 110 Val Asn Gly Ile Pro Ile Tyr Val Ala Pro Tyr Val Glu Ile Gly Thr 115 120 125 Val Ile Phe Pro Val Thr Phe Gln Ser Val Asp Arg Ile Ser Val Thr 130 135 140 Lys Gly Gly Glu Ser Val Arg Tyr Gly Pro Asn Ala Phe Gly Gly Val 145 150 155 160 Ile Asn Ile Ile Thr Lys Gly Ile Pro Thr Asn Trp Glu Ser Gln Val 165 170 175 Ser Glu Arg Thr Thr Phe Trp Gly Lys Ser Glu Asn Gly Gly Phe Phe 180 185 190 Asn Gln Asn Ser Lys Asn Ile Asp Lys Ser Leu Val Asn Asn Met Leu 195 200 205 Phe Asn Thr Tyr Leu Arg Thr Gly Gly Met Met Asn Lys His Phe Gly 210 215 220 Ile Gin Ala Gln Val Asn Trp Leu Lys Gly Gin Gly Phe Arg Tyr Asn 225 230 235 240 Ser Pro Thr Asp Ile Gln Asn Tyr Met Leu Asp Ser Leu Tyr Gln Ile 245 250 255 Asn Asp Ser Asn Lys Ile Thr Ala Phe Phe Gln Tyr Tyr Ser Tyr Phe 260 265 270 Leu Thr Asp Pro Gly Ser Leu Gly Ile Ala Ala Tyr Asn Gin Asn Arg 275 280 285 Phe Gln Asn Asn Arg Pro Asn Asn Asp Lys Ser Gly Arg Ala Lys Arg 290 295 300 Trp Gly Ala Val Tyr Gln Asn Phe Phe Gly Asp Thr Asp Arg Val Gly 305 310 315 320 Gly Gly Phe His Phe 325 PCT/US 9 6 0912 2 692 IPENUS '8 1996 692 INFORMATION FOR SEQ ID NO:833: SEQUENCE CHARACTERISTICS: LENGTH: 325 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...325 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:833 Met Lys Arg Ile Leu Val Ser Leu Ala Val Leu Ser His Ser Ala His 1 Asn Tyr Ala Ile Gly Val Val Lys 145 Ile Ser Asn Phe Ile 225 Ser Asn Leu Phe Trp 305 Gly Val Asp Met Asn Arg Phe Asn Ile 130 Gly Asn Glu Gin Asn 210 Gin Pro Asp Thr Gin 290 Gly Gly Lys Lys Gly Gin Asn Gly Gly 115 Phe Gly Ile Arg Asn 195 Thr Ala Thr Ser Asp 275 Asn Ala Phe Thr Glu Ser Ser Ser Ala 100 Ile Pro Glu Ile Thr 180 Ser Tyr Gin Asp Asn 260 Pro Asn Val His 5 His Ala Arg Ile Thr Gly Pro Val Ser Thr 165 Thr Lys Leu Val Ile 245 Lys Gly Arg Tyr Phe 325 Asn Pro Thr Gu 70 Gly Gly Ile Thr Val 150 Lys Phe Asn Arg Asn 230 Gin Ile Ser Pro Gin 310 Leu Leu Val 55 Glu Ile Pro Tyr Phe 135 Arg Gly Trp Ile Thr 215 Trp Asn Thr Leu Asn 295 Asn Glu Ser 40 Ile Ala Gly Gly Val 120 Gin Tyr Ile Gly Asp 200 Gly Leu Tyr Ala Gly 280 Asn Phe Arg 25 Trp Ser Leu Ala His 105 Ala Ser Gly Pro Lys 185 Lys Gly Lys Met Phe 265 Ile Asp Phe 10 Val Arg Asn Gin Val 90 Ser Pro Val Pro Thr 170 Ser Ser Met Gly Leu 250 Phe Ala Lys Gly Glu Ser Lys Asn 75 Pro Asn Tyr Asp Asn 155 Asn Glu Leu Met Gin 235 Asp Gin Ala Ser Asp 315 Ala Lys Gln Val Ser Thr Val Arg 140 Ala Trp Asn Val Asn 220 Gly Ser Tyr Tyr Gly 300 Thr Ser Glu Leu Pro Ile Gly Glu 125 Ile Phe Glu Gly Asn 205 Lys Phe Leu Tyr Asn 285 Arg Asp Gly Val rhr Gly Ser Met 110 Ile Ser Gly Ser Gly 190 Asn His Arg Tyr Ser 270 Gin Ala Arg Val Arg Lys Val Ile Ile Gly Val Gly Gin 175 Phe Met Phe Tyr Gin 255 Tyr Asn Lys Val Ala Asn Ser His Arg Leu Thr Thr Val 160 Val Phe Leu Gly Asn 240 Ile Phe Arg Arg Gly 320 INFORMATION FOR SEQ ID NO:834: qI"~Y POUS 96/09122a EPENUS 16 ULU 1996 693 SEQUENCE CHARACTERISTICS: LENGTH: 252 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .252 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:834 Leu Arg Sen Ile Sen Arg Ile Lys Met Leu Ser Val 1 Asn Ile Asn Asn Lys Leu Glu Val Ser 145 Gly Tyr Lys Phe Unk 225 Arg Ala Leu Ala Gly Thr Gin Glu Gly 130 Leu Ile Arg Unk Asn 210 Asp Leu Leu Met Sen Gly Leu Lys Lys 115 Ser Ser Asp Leu Lys Gin Leu Ang Asp Glu Leu Asp Vali Giu 100 Asn Ala Gin Sen Sen 180 Unk Ile Lys Ala 5 Lys Arg Asn Ala Gly Ala Gly Tyr 70 Phe Giu Ang Ala Giu Asp Phe Lys Lys Ala 150 Lys Gly 165 Ala Trp Tyr Ile Tyr Giu Leu Pro 230 Cys Ala 245 Val1 Ala Lys 55 Thn Met Lys Leu Gly 135 Ang Ang Ala Unk Ile 215 Leu Cys Leu Met 40 Val1 Leu Lys Lys Glu 120 Gly Phe Val1 Leu Unk 200 Pro Arg Ala C lu 25 Ala Ile Ala Leu Val1 105 Cys Leu Lys Asp Phe 185 Leu Thr Asp Phe 10 Giu Leu Ile Ang Ala 90 Gly Asp Giu Ile Lys 170 Lys Lys Unk Arg Tnp Giu Leu Arg 75 Lys Val1 Val1 Pro Ala 155 Ang Sen Unk Thn Lys 235 Leu Arg Cys Leu Sen Val1 Leu Phe 140 Cys Ala Cys Unk Phe 220 Lys Tyr Leu Ala G ly Val1 Pro Ile Val1 125 Leu Asp Phe Leu His 205 Leu Arg Giu Sen Val1 Ser Gly Met Lys 110 Asp Asp Ile Lys Leu 190 Leu Leu Sen Lys Giu Leu Gly Arg Cys Ala Cys Phe Pro Unk 175 Sen Unk Giu Gin Gly Asp Gin Asp Phe Gin Trp Val C iu Sen 160 Gly Unk Val Lys Ang 240 Gly Gin Ala 250 INFORMATION FOR SEQ ID NO:834: i)SEQUENCE CHARACTERISTICS: LENGTH: 252 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: POT/US 96/0912.
IPENUS 18 DE C1996 694 ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...252 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:834 Leu Arg Ser Ile Ser Arg Ile Lys Met Leu Ser Val Tyr Glu Lys Gly 1 5 10 Asn Ala Leu Asp Lys Arg Val Leu Glu Glu Trp Leu Leu Ser Glu Asp 25 Ile Leu Met Glu Asn Ala Ala Met Ala Leu Glu Arg Ala Val Leu Gin 40 Asn Ala Ser Leu Gly Ala Lys Val Ile Ile Leu Cys Gly Ser Gly Asp 55 Asn Gly Gly Asp Gly Tyr Thr Leu Ala Arg Arg Leu Val Gly Arg Phe 70 75 Lys Thr Leu Val Phe Glu Met Lys Leu Ala Lys Ser Pro Met Cys Gin 90 Leu Gln Lys Glu Arg Ala Lys Lys Val Gly Val Val Ile Lys Ala Trp 100 105 110 Glu Glu Lys Asn Glu Asp Leu Glu Cys Asp Val Leu Val Asp Cys Val 115 120 125 Val Gly Ser Ala Phe Lys Gly Gly Leu Glu Pro Phe Leu Asp Phe Glu 130 135 140 Ser Leu Ser Gln Lys Ala Arg Phe Lys Ile Ala Cys Asp Ile Pro Ser 145 150 155 160 Gly Ile Asp Ser Lys Gly Arg Val Asp Lys Arg Ala Phe Lys Unk Gly 165 170 175 Tyr Arg Leu Ser Ala Trp Ala Leu Phe Lys Ser Cys Leu Leu Ser Unk 180 185 190 Lys Unk Lys Unk Tyr Ile Unk Unk Leu Lys Unk Unk His Leu Unk Val 195 200 205 Phe Asn Gln Ile Tyr Glu Ile Pro Thr Unk Thr Phe Leu Leu Glu Lys 210 215 220 Unk Asp Leu Lys Leu Pro Leu Arg Asp Arg Lys Lys Arg Ser Gln Arg 225 230 235 240 Arg Leu Arg Ala Cys Ala Cys Ala Phe Gly Gln Ala 245 250 INFORMATION FOR SEQ ID NO:835: (i).SEQUENCE CHARACTERISTICS: LENGTH: 597 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...597 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:835 Met Ser Asn Gln Glu Tyr Thr Phe Gln Thr Glu Ile Asn Gln Leu Leu 1 5 10 Asp Leu Met Ile His Ser Leu Tyr Ser Asn Lys Glu Ile Phe Leu Arg PCT/'S 96/09122 IPENUS 18 EC1996 Glu Leu Ile Ser Asn Ala Ser Asp Ala Leu Asp Met His Gly Ala Lys Ala Ser 145 Ile Leu Val Tyr Lys 225 Met Ser Val Ala Tyr 305 Ser Leu Ile Ser Val 385 Leu Leu Tyr Glu Ile 465 Phe Glu Phe Leu Leu Ile Lys Lys Phe 130 His Ser Lys Val Thr 210 Glu Asn Phe Glu Pro 290 Val Tyr Asn Arg Lys 370 Leu Glu Lys Leu Lys 450 Asp Arg Ile Glu Thr Ser Gly Ser Asp 115 Met Gin Glu Glu Lys 195 Asp Glu Lys Ala Gly 275 Phe Lys Leu Val Ser 355 Asp Lys Leu Glu Leu 435 Tyr Ala Asp His Glu 515 A.p Phe Met Gly 100 Ser Val Ala Cys Glu 180 Lys Thr Lys Ser His 260 Ser Asp Arg Arg Ser 340 Ala Asn Glu Leu Tyr 420 Gly Ala Phe Ala Asp 500 Asn Glu Asp Asp Thr Ala Ala Tyr Val 165 Asp Tyr Lys Cys Glu 245 Asp Leu Leu Val Phe 325 Arg Ser Lys Gly Arg 405 Lys Glu Gin Val Ser 485 Glu Leu Lys Ser 70 Lys Lys Leu Ser Ala 150 Lys Ser Ser Phe Asp 230 Leu Asn Glu Phe Phe 310 Val Glu Val Asn Leu 390 Phe Glu Asn Lys Met 470 His Val Lys Leu 55 Gin Ser Ser Ile Lys 135 Trp Glu His Glu Glu 215 Gin Lys Ser Tyr Arg 295 Ile Lys Ile Lys Tyr 375 Tyr Tyr Asn Leu Gly 455 Pro Ser Lys Asp Ala 535 40 Lys Lys Asp Phe Gly 120 Ile Val Glu Phe His 200 Gly Ile Glu Glu Thr 280 Val Thr Gly Leu Lys 360 His Gly Ser Leu Asp 440 Tyr Gly Glu Asp Glu 520 Gly Lys Leu Leu 105 Gin Val Ser Gin Ala 185 Ile Glu Asn Lys Pro 265 Thr Asp Asp Val Gin 345 Ile Lys Asp Lys Lys 425 Leu Asp Val Ser Gin 505 Ile Leu Thr Ile 90 Ser Phe Val Asp Gly 170 Ser Pro Gly Gin Asp 250 Leu Leu Tyr Asp Ile 330 Gin Leu Phe Phe Asp 410 Glu Leu Val Asn Leu 490 Phe Lys Asn Leu 75 Glu Ala Gly Gin Gly 155 Thr Arg Phe Asp Ala 235 Tyr Ser Phe Lys Asp 315 Asp Asn Ser Tyr Glu 395 Lys Asn Lys Leu Glu 475 Lys Lys Gly Lys Thr Thr His Leu Val Thr 140 Lys Glu Trp Pro Asn 220 Ser Lys Tyr Tyr Ser 300 Lys Ser Lys Glu Glu 380 Asn Gly Gin Ala Leu 460 Tyr Glu Asp Val Leu Thr Ile Leu Ser Gly 125 Lys Gly Ile Glu Ile 205 Lys Ala Asp Ile Ile 285 Gly Glu Glu Ile Ile 365 Pro Lys Glu Lys Ser 445 Leu Asp Leu Leu Glu 525 Asn Pro Lys Gly Gly 110 Phe Lys Lys Thr Ile 190 Phe Lys Leu Phe His 270 Pro Val Leu Asp Leu 350 Glu Phe Glu Trp Ser 430 Pro Ser Lys Gly Ile 510 Leu Tyr Ser Asp Thr Asp Tyr Val Phe Leu 175 Asp Leu Glu Trp Tyr 255 Asn Ser Lys Leu Leu 335 Ala Arg Gly Lys Ile 415 Ile Leu Asp Thr Leu 495 Lys Ser Leu Ile Asn Ile Lys Ser Thr Glu 160 Phe Ser Thr Val Lys 240 Gin Lys Lys Leu Pro 320 Pro Asn Leu Lys Leu 400 Ser Tyr Leu Glu Pro 480 Ala Ala Gly His Leu 530 Thr Ser Ala Val Leu Ile Gly Asp Glu Pro Asn Ala Met PCT/US 96/0912Z PENUS18 DECi 696 Met Ala Asn Trp Met Arg Gln Met Gly Gln Ser Val Pro Glu Ser Lys 545 550 555 560 Lys Thr Leu Glu Leu Asn Pro Asn His Ala Ile Leu Gln Lys Leu Leu 565 570 575 Lys Cys Glu Asp Lys Glu Gln Leu Ser Ala Phe Ile Trp Leu Leu Tyr 580 585 590 Asp Gly Arg Ser Phe 595 INFORMATION FOR SEQ ID NO:836: SEQUENCE CHARACTERISTICS: LENGTH: 156 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...156 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:836 Val Asn Leu Gly Ala Tyr Tyr Thr Pro Pro Tyr Leu Val Asp Cys Ala 1 5 10 Tyr Lys Leu Leu Lys Lys His Val Gly Ile Glu Asn Tyr Thr Leu Leu 25 Asp Thr Ala Cys Gly Asn Lys Glu Phe Leu Lys Leu His His Pro Lys 40 Lys Ile Gly Ala Asp Ile Asp Pro Lys Cys Asp Ala Leu Ile Ile Asn 55 Ala Leu Ala Asn Pro Lys Arg Glu Asn Tyr Gly Ile Ser Gln Asp Glu 70 75 Pro Leu Ile Ile Val Gly Asn Pro Pro Tyr Asn Asp Arg Thr Ser Phe 90 Ile Lys Gln Asp Ile Lys Asn Lys Asp Phe Ile Phe Glu Ile Asp Asn 100 105 110 Asp Leu Lys Ser Arg Asp Leu Gly. Ile Ser Phe Leu Lys Ser Phe Ala 115 120 125 Ile Leu Lys Pro Ala Phe Ile Cys Val Leu His Pro Leu Ser Tyr Leu 130 135 140 Ile Lys Glu Ala Asn Phe Lys Gln Phe Lys Ala Ile 145 150 155 INFORMATION FOR SEQ ID NO:837: SEQUENCE CHARACTERISTICS: LENGTH: 157 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori PCT/US 96/09122 IPENUS 18 bD E 1996 697 (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...157 SEQUENCE DESCRIPTION: SEQ ID NO:837 Met Lys Ser Ile Leu Leu Phe Ile Ile Phe Val Val Cys Gin Leu Glu 1 5 10 Gly Lys Lys Phe Ser Gin Asp Asn Phe Lys Val Asp Tyr Asn Tyr Tyr 25 Leu Arg Lys Gin Asp Leu His Ile Ile Lys Thr Gln Asn Asp Leu Ser 40 Asn Ala Trp Tyr Leu Pro Pro Gin Lys Ala Pro Lys Glu His Ser Trp 55 Val Asp Phe Ala Lys Lys Tyr Leu Asn Met Met Asp Tyr Leu Gly Thr 70 75 Tyr Phe Leu Pro Phe Tyr His Ser Phe Thr Pro Ile Phe Gln Trp Tyr 90 His Pro Asn Ile Asn Pro Tyr Lys Arg Asn Glu Phe Lys Phe Gln Ile 100 105 110 Ser Phe Arg Val Pro Val Phe Arg His Ile Leu Trp Thr Lys Gly Thr 115 120 125 Leu Tyr Leu Asp Tyr Thr Gin Thr Asn Trp Phe Gln Ile Tyr Asn Asp 130 135 140 Pro Gin Ser Ala Pro Met Arg Met Ile Lys Phe His Ala 145 150 155 INFORMATION FOR SEQ ID NO:838: SEQUENCE CHARACTERISTICS: LENGTH: 191 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...191 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:838 Met Gly Leu Met Gly Val Ser Gin Gly Leu Pro Asn Thr Thr Ser Lys 1 5 10 Phe Gly Ile Glu Phe Asp Ser Leu Ala Asp Val Val Ala Phe Gly Val 25 Ala Pro Ser Leu Ile Thr Tyr Phe Tyr Val Gly Tyr Asn Phe Gly Arg 40 Ile Gly Met Ala Val Ser Ala Leu Phe Val Ile Phe Gly Ala Ile Arg 55 Leu Ala Arg Phe Asn Ile Ser Thr Asn Thr Ser Asp Pro Tyr Ser Phe 70 75 Ile Gly Ile Pro Ile Pro Ala Ala Ala Val Leu Val Val Leu Cys Val 90 Leu Leu Asp Asn Lys Tyr His Phe Leu Glu Gly Asn Thr Glu Lys Leu 100 105 110 \he Leu Gly Phe Ile Val Leu Leu Gly Val Leu Met Val Ser Asn Ile 115 120 125 PG'/US 9 6 091 Z.
IPEAJS 18 DEC1996 698 Arg Tyr Pro Asn Phe Lys Lys Val Lys Trp Asn Leu Lys Leu Phe Ile 130 135 140 Leu Val Leu Ile Phe Leu Ser Leu Val Phe Val Arg Pro Leu Glu Ala 145 150 155 160 Leu Ser Val Phe Met Gly Leu Tyr Leu Ile Tyr Gly Ile Ile Arg Trp 165 170 175 Ile Phe Leu Met Val Lys Ile Thr Phe Asn Lys Asn Lys Ser Ala 180 185 190 INFORMATION FOR SEQ ID NO:839: SEQUENCE CHARACTERISTICS: LENGTH: 90 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...90 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:839 Met Ile Gly Val Tyr Pro Asn Tyr Ser Lys Lys Gln Leu Lys Arg Pro 1 5 10 Leu Val Ile Phe Val Ser Arg Glu Leu Ala Leu Ala Asn Gly Ile Leu 25 Thr Asp Ala Tyr Asp Ile Glu Ala Asn Leu Tyr Met Asn Ala Arg Ile 40 Val Met Unk Asn Asn Lys Arg Lys His Tyr Glu Gln Arg Val Asn Leu 55 His Phe Unk Arg Ser Leu Gly Unk Val Phe Asp His Arg Ser Asn His 70 75 Val Leu Cys Asp Glu Lys Asp Leu Leu Arg INFORMATION FOR SEQ ID NO:840: SEQUENCE CHARACTERISTICS: LENGTH: 277 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_ feature LOCATION 1...277 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:840 1 Lys Ile Thr Ile Met Ile Lys Asp Phe Asn His Tyr Cys Arg Lys PTU11 K 9 1 a91a IPEN/US 18 b t 1996 1 Ile Lys Val1 Phe Cys Asn Ile Leu Ile 145 Ser Arg Pro Thr Giu 225 Val1 Pro Cys Thr Met Val1 Glu Ile Gly G iu Ser 130 Pro Gin Lys Leu Giu 210 Val1 Gin Leu Ala Arg Lys Ser Lys Glu Pro Asn 115 Trp Asp Asn Gin Ser 195 Ser Pro Gin Thr Ile 275 5 Gly P) Lys A Leu A.
Cys L.
Val L' 8 Leu G 100 Pro L Gin A Tyr A His P 1 Leu A 180 Giy G Giu L Asn A Ser A 2 Leu A 260 Leu P ia sn eu in eu la he 65 iy eu la ~sp :45 Isn Lrg Val Lys Giy Phe Ala Lys 55 Pro Asn 70 Pro Asp Tyr Leu Leu Leu Arg Asp 135 Ile Ser 150 His Ile Asn Asn Leu Asn Ala Gin 215 His Lys 230 Asn Ser Arg Ala Ile Leu 40 Asp Tyr Ala Leu Asp 120 Phe Leu His Leu Giy 200 Lys Arg Phe Ser Pro 25 Phe Pro Giu Gly Met 105 Pro Met Thr Ile Lys 18S His Ser Met Val1 Ala 265 10 Thr Leu Asn Lys Tyr 90 Pro Ser Ser Ile Ser 170 As n Lys Pro Gly Leu 250 Glu Lys Aia Val1 Asn 75 Val1 Thr Thr Unk Asn 155 Cys Ile Tyr Phe Asp 235 Leu Glu Lys Ala Leu Gin Val1 Thr Pro Lys 140 Ser Ile Asn Leu Val1 220 Tyr Aia Ile Gin Met Arg Asn Leu His Asn 125 Tyr Lys Ser Ser Aia 205 Met Giy Thr Gin Ala Lys Pro Lys Ile 110 Phe Giy Lys Leu Arg 190 Arg Leu Leu Gin Asp 270 i5 Ala Ile Ile Ser Asp Ser Phe Lys Gly Asp 175 Trp Arg Aia Aia Phe 255 His Lys Ile Vai Pro Ile Gly Tyr Pro Arg 160 Val1 Ser Val1 Lys Val1 240 As n Glu INFORMATION FOR SEQ ID NO:841: SEQUENCE CHARACTERISTICS: LENGTH: 58 amino acids TYPE: amino acid TOPOLOGY: linear (ii).MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc_feature LOCATION .58 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:841 Val Leu Thr Ser Gly Asp Met Ile Thr Cys Pro Tyr Cys Gly Arg Ile 10 Leu Tyr Ala Giu Ser Thr His Glu Ser Asn Aia Gin Pro Pro Lys Glu 25 Ser Gin Pro Lys Glu Ser Gin Giu Glu Ser Gin Glu Giu Ser Gin Giu 40 liu Ser Gin Giu Ala Val Arg Leu Ile Val 'V 700 INFORMATION FOR SEQ ID NO:842: SEQUENCE CHARACTERISTICS: LENGTH: 138 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...138 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:842 Met Ala Leu Asp Lys Arg Ile Trp Met His Phe Asp Leu Leu Pro Phe 1 5 10 Val Phe Ile lie Pro Leu Leu Val Val Ser Phe Leu Leu Ile Phe Glu 25 Ser Ser Ala Val Leu Ser Leu Lys Gin Gly Val Tyr Tyr Ala Ile Gly 40 Phe Leu Leu Phe Trp Val Val Phe Phe Ile Pro Phe Arg Lys Leu Asp 55 Arg Trp Leu Phe Ala Leu Tyr Trp Ala Cys Val Ile Leu Leu Ala Leu 70 75 Val Asp Phe Met Gly Ser Ser Lys Leu Gly Ala Gin Arg Trp Leu Val 90 Ile Pro Phe Thr Ser Ile Thr Leu Gln Pro Ser Glu Pro Val Lys Asn 100 105 110 Arg Unk Ser Phe Ile Val Gly Ala Phe Unk Unk Asn Unk Pro Asp Unk 115 120 125 Leu Leu Arg Ala Met Ile Gly Ala Cys Phe 130 135 INFORMATION FOR SEQ ID NO:842: (i).SEQUENCE CHARACTERISTICS: LENGTH: 138 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...138 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:842 \et Ala Leu Asp Lys Arg Ile Trp Met His Phe Asp Leu Leu Pro Phe S 10 1 Phe Ile Ile Pro Leu Leu Val Val Ser Phe Leu Leu Ile Phe Glu
-CT
091 2 IPEAUS 1 3 701 25 Ser Ser Ala Val Leu Ser Leu Lys Gln Gly Val Tyr Tyr Ala Ile Gly 40 Phe Leu Leu Phe Trp Val Val Phe Phe Ile Pro Phe Arg Lys Leu Asp 55 Arg Trp Leu Phe Ala Leu Tyr Trp Ala Cys Val Ile Leu Leu Ala Leu 70 75 Val Asp Phe Met Gly Ser Ser Lys Leu Gly Ala Gln Arg Trp Leu Val 90 Ile Pro Phe Thr Ser Ile Thr Leu Gln Pro Ser Glu Pro Val Lys Asn 100 105 110 Arg Unk Ser Phe Ile Val Gly Ala Phe Unk Unk Asn Unk Pro Asp Unk 115 120 125 Leu Leu Arg Ala Met Ile Gly Ala Cys Phe 130 135 INFORMATION FOR SEQ ID NO:843: SEQUENCE CHARACTERISTICS: LENGTH: 279 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...279 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:843 Met Lys Leu Asn Asp Pro Phe Thr Ser Pro Asn Lys Ala Lys Lys Glu 1 5 10 Leu Ser Pro Lys Gly Phe Arg Gly Gly Leu Glu Ser Glu Ile Leu Leu 25 Gly Phe Val Leu Gln Lys Glu Arg Val Phe Leu His Thr His Glu His 40 Leu Giu Leu Ser His Glu Glu Glu Thr Arg Phe Phe Glu Leu Val Gly 55 Lys Arg Leu Asn Asp Cys Pro Ile Glu Tyr Leu Leu Gly Ser Cys Asp 70 75 Pha Tyr Gly Arg Ser Phe Phe Val Asn Glu His Val Leu Ile Pro Arg 90 Pro Glu Thr Glu Ile Leu Val Gln Lys Ala Leu Asn Ile Ile Ser Gin 100 105 110 Tyr His Leu Lys Glu Ile Gly Glu Ile Gly Ile Gly Ser Gly Cys Val 115 120 125 Ser Val Ser Leu Ala Leu Glu Asn Pro Asn Leu Ser Ile Tyr Ala Ser 130 135 140 Asp Ile Ser Pro Lys Ala Leu Glu Val Ala Leu Lys Asn Ile Glu Arg 145 150 155 160 Phe Cys Leu Lys Glu Arg Val Phe Leu Lys Gln Thr Arg Leu Trp Asp 165 170 175 His Met Pro Thr Ile Glu Met Leu Val Ser Asn Pro Pro Tyr Ile Ala 180 185 190 Arg Asn Tyr Pro Leu Glu Lys Ser Val Leu Lys Glu Pro His Glu Ala 195 200 205 u Phe Gly Gly Val Lys Gly Asp Glu le Leu Lys Glu Ile Val Phe 210 215 220 iPEAiUS i o ocu 96 702 Leu Ala Ala Lys Leu Lys lie Pro Phe Leu Val Cys Glu Met Gly Tyr 225 230 235 240 Asp Gln Leu Lys Ser Leu Lys Glu Cys Leu Glu Phe Cys Gly Tyr Asp 245 250 255 Ala Glu Phe Tyr Lys Asp Leu Ser Gly Phe Asp Arg Gly Phe Val Gly 260 265 270 Val Leu Lys Ser Phe Leu Arg 275 INFORMATION FOR SEQ ID NO:844: SEQUENCE CHARACTERISTICS: LENGTH: 36 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...36 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:844 Met Ile Ser Phe Ile Gly Phe Glu Cys Ser Ala Leu Lys Val Phe Leu 1 5 10 Thr Phe Gly Tyr Ile Val Phe Lys Unk Trp His Tyr Ser Ala Ile Arg 25 Leu Ile Val Ile INFORMATION FOR SEQ ID NO:845: SEQUENCE CHARACTERISTICS: LENGTH: 129 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .129 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:845 Val Ile Gin Ser His Pro Lys Gin Thr Leu Ile Glu Asp Glu Asn Tyr 1 5 10 Phe Tyr Ala Asn Lys Gly Leu Tyr Lys Thr Asn Lys Glu Ala Phe Leu 25 Arg Val Tyr Lys Ile Pro Glu Ser Met Pro Ile Glu Lys Arg Glu Ser 40 4S Leu Ser Lys Val Ser Lys Ile Phe Leu Ala Leu Leu Phe Phe Ile Ser %0 0 702 Leu Ala Ala Lys Leu Lys Ile Pro Phe Leu Val Cys Glu 225 230 235 Asp Gln Leu Lys Ser Leu Lys Glu Cys Leu Glu Phe Cys 245 250 Ala Glu Phe Tyr Lys Asp Leu Ser Gly Phe Asp Arg Gly 260 265 Val Leu Lys Ser Phe Leu Arg 275 INFORMAT:IN FOR SEQ ID NO:844: SEQUENCE
CHARACTERISTICS:
LENGTH: 36 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_£feature LOCATION 1...36 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:844 Met Ile Ser Phe Ile Gly Phe Giu Cys Ser Ala Leu Lys 1 5 Thr Phe Gly Tyr Ile Val Phe Lys Unk Trp His Tyr Ser Leu Ile Val Ile INFORMATION FOR SEQ ID NO:845: SEQUENCE CHARACTERISTICS: LENGTH: 129 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc.feature LOCATION 1...129 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:845 Val Ile Gln Ser His Pro Lys Gin Thr Leu Ile Glu As 1 5 Phe Tyr Ala Asn Lys Gly Leu Tyr Lys Thr Asn Lys Gl 40 eu Ser Lys Val Ser Lys Ile Phe Leu Ala Leu Leu Pt PCT' 2 /091 2.
IPEANUS 1ou 703 55 Ser Met Leu'Phe Gly Ile Phe Trp Arg Leu Pro Lys Arg Leu Asp Thr 70 75 Lys Met Ser Leu Glu Ser Ala His Lys Asn Glu Leu Glu Asn Ala Phe 90 Gin Arg Tyr Asp Ala Leu Gly Val Arg Phe Glu Asp Ile Ala Gly Val 100 105 110 Asn Glu Val Lys Glu Glu Leu Leu Glu Val Ile Asp Tyr Leu Lys Lys 115 120 125 Pro INFORMATION FOR SEQ ID NO:846: SEQUENCE CHARACTERISTICS: LENGTH: 127 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...127 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:846 Met Phe Val Val Lys Met Val Leu Gly Phe Leu Ile Leu Leu Ser Pro 1 5 0 Leu Cys Ala Thr Gly Leu Asp Ile Ser Gln Thr Asp Ile Ile Giu Arg 25 Ser Leu Asn Phe Leu Leu Phe Val Gly Ile Leu Trp Tyr Phe Leu Ala 40 Lys Arg Leu Arg Ser Phe Leu His Ser Lys Ser Leu Glu Ile Ser Lys 55 Arg Leu Glu Glu Ile Gin Ala Gln Leu Lys Val Ser Lys Glu His Lys 70 75 Lys Lys Leu Leu Lys Glu Leu Glu Gln Ala Lys Glu Lys Ala Glu Leu 90 Ile Ile Ser Asp Ala Asn Lys Glu Ala Leu His Asp His Ala Lys Ile 100 105 110 Arg Ile Thr Asn Gln Asn Gly Cys Gly Lys Phe Asp Gln Lys Phe 115 120 125 INFORMATION FOR SEQ ID NO:847: SEQUENCE CHARACTERISTICS: LENGTH: 276 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori IPET/US 0c 996 IPEA/US i b c. 1996 704 (ix) FEATURE: NAME/KEY: misc.feature LOCATION 1...276 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:847 Met Arg Val Leu Glu Trp Lys Tyr Trp Leu Asn 1 Thr Ile Ser Ser Leu Pro Ala Ile Glu 145 Lys Ala Val Tyr Ala 225 As n Gin Val Pro Gin Met Asn Thr Lys Gin Ala 130 Glu Met Met Leu Gly 210 Gin Leu Ala Phe Thr lie Lys Ala Arg Asp Ile 115 Arg Val Asp Ala Asp 195 Ala Ile Ser Leu Lys 275 5 Asn Lys Gly Ile Asn Ala Leu Leu Ala Leu Ala Ile 100 Ala Gin Pro Lys Tyr Ala Ser Leu 165 Asn Pro 180 Arg Leu Ser Ile Gly Phe Tyr Phe 245 Ile Ile 260 Asp Pro Asn Lys 55 Gin Ala Ile Ala Leu 135 Gly Ile Leu Leu Gin 215 Ala Ile Gin Asn 40 Ala Asp Leu Ser Pro 120 Tyr Val Leu Ala Thr 200 Ala Leu Asp Thr 25 Phe Phe Leu Val Phe 105 Phe Asp Leu Lys Pro 185 Pro His Ser Lys Gly 265 10 Phe Asn Ala Lys Lys 90 Asn Asp Glu Val Asp 170 Tyr Ser Gin Leu Thr 250 Ala Lys His Leu Ile Glu Ser Leu Lys Leu 155 Pro Gly Leu Phe Ile 235 Leu Asn Thr Ile Leu Leu Ala Phe Ser Phe Ile 140 Trp Lys Lys Lys Ile 220 Asp Tyr Asn Asp Gin Ile Ile Ala Gin Gly Ile 125 Thr Ser Ile Ala Ser 205 Ala Lys Asn Pro Lys Ile Lys Val Ala Lys Lys 110 Ser Pro Glu Lys Ser 190 Lys Thr Lys Pro Leou 270 Trp Phe Gly Phe Ala Glu Leu Ala Phe Asn Arg 175 Met Ile Lys Asp Ile 255 Ala Thr Lys Asn INFORMATION FOR SEQ ID NO:848: SEQUENCE CHARACTERISTICS: LENGTH: 126 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...126 S (xi) SEQUENCE DESCRIPTION: SEQ ID NO:848 Va Ala Leu Leu Glu Pro Ser Val Met Tyr Lau Thr Glu Lys Tyr Gin lPEAt~ 1 Tyr Val Leu Ser Gly Leu Thr Ser Gly Thr Thr Trp Gly Pro Arg Val Phe Ile Val Pro Leu 115 Phe Val Phe Ile Leu Lys 100 Ile Trp Set Leu Gly Lys Thr Ile 120 INFORMATION FOR SEQ ID NO:849: SEQUENCE CHARACTERISTICS: LENGTH: 242 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION 1...242 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:849 Val Gly Leu Met Lys Ile Arg Phe Met Gly Arg Ser Val Phe 1 Asp Leu Leu Gly Ile Ala His Phe Lys Ile Val Ala Ser Gly Phe Tyr 130 Tyr Gln 145 Ala Lys Ala Pro Asn G1n Glu Gly Leu Lys Gin Phe Gin 115 Pro Ala Lys Phe Leu Arg Gln Lys Glu Ser Ser 100 Val Phe Phe Phe Lys 180 Leu 5 Ile Lys His Asp Val Leu Leou Giu Glu Phe 165 Gly Cys Glu Ala Gln Glu 70 Ala Gly Glu Ile Lys 150 Asn His Glu Glu Ile Leu 55 Leou Thr Val Asn Lys 135 Asp Ser Val Gln Lys 215 Val Lys 40 Asn Gly Asn Val Leu 120 Asn Leu Leu Val Leu 200 His Ala 25 Glu Lys Ile Ser Gly 105 Ala Ser Gly Val Va 1 185 Ala Phe 10 Arg Pro Leu Phe Ile 90 Thr Leu Val Val Glu 170 Cys Lys Pro Phe Arg Leu Lys 75 Gly Ile Gin Val Leu 155 Ile Ser Arg Pro Glu Arg Lys Gln Arg Ser Ser Arg 140 Giu Ile Gly Leu Asn 220 Glu Leu Arg Met Leu Phe Asp 125 Leu Pro Thr Gly Lys 205 Asp Phe Val Val His Phe Glu 110 Glu Lys Lys Ala Va 1 190 Lys Arg Val Trp Leu Gln Asp Asp Ala Ile Glu Arg Leu 175 Phe Leou Ser Gly Leu Glu Lys Lys Ile Glu Ala Phe Ile 160 Ile Cys Gln Ile 195 G1u Tyr Phe Phe His P* 96/091Z IPENUSI 706 Pro Val Gly Gin Ala Leu Met Ala Tyr Phe Asn Pro Thr Ile Ile Lys 225 230 235 240 Lys Gly INFORMATION FOR SEQ ID NO:850: SEQUENCE CHARACTERISTICS: LENGTH: 151 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION 1...151 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:850 Val Ser Asp Ser Asn Ala Leu Lys Glu Val Phe Leu Asn Ile Ser Ala 1 5 10 Lys Glu Asp His Cys Asp Val Leu Ile Asn Ser Ala Gly Tyr Gly Val 25 Phe Gly Ser Val Glu Asp Thr Pro Ile Glu Glu Val Lys Lys Gln Phe 40 Ser Val Asn Phe Phe Ala Leu Cys Glu Val Val Gin Leu Cys Leu Pro 55 Leu Leu Lys Asn Lys Pro Tyr Ser Lys Ile Phe Asn Leu Ser Ser Ile 70 75 Ala Gly Arg Val Ser Met Leu Phe Leu Gly His Tyr Ser Ala Ser Lys 90 His Ala Leu Glu Ala Tyr Ser Asp Ala Leu Arg Leu Glu Leu Lys Pro 100 105 110 Phe Asn Val Gin Val Cys Leu Ile Glu Pro Gly Pro Val Lys Ser Asn 115 120 125 Trp Glu Lys Thr Ala Ph* Glu Asn Asp Glu Arg Lys Asp Ser Val Tyr 130 135 140 Ala Leu Glu Val Asn Ala Ala 145 150 INFORMATION FOR SEQ ID NO:851: SEQUENCE CHARACTERISTICS: LENGTH: 154 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc.feature 4u1 LOCATION 1...154 707 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:851 Val Ile Val Ala Trp Leu Phe Arg Phe Lys Ser Ile Ala Phe Ser Ile 1 5 10 Leu Ile Thr Leu Leu Val Ile Leu Val Asp Ile Trp Val Tyr Ser Asp 25 val Arg Gln Phe Leu Leu Asp Thr Ser Ser Ser Phe Ile Trp Leu Leu 40 Ile Ala Leu Leu Ile Lys Trp Gly Val Ile Val Ile Ser Ala Arg Lys 55 Cys Tyr Gln Phe Ser Gln Lys Met Phe Ala Leu Ile Gln Arg Lys Arg 70 75 Gin Ile Arg Glu Asn Leu Lys Asn Arg Ser Asn Arg Lys Asp Ala Lys 90 Asn Phe Glu Lys Leu Ser Asn Ile Ala Glu Glu Ile Ile Ser Lys Lys 100 105 110 Gin Glu Glu Ser His His Lys Glu Asp Ser Asn Asp Glu Asn His Lys 115 120 125 Asp Lys Leu Ser Asn Ile Thr Glu Glu Met Ile Leu Lys Lys Gin Glu 130 135 140 Glu Leu Lys Ala Arg Lys Asp Lys Gly Asp 145 150 INFORMATION FOR SEQ ID NO:852: SEQUENCE CHARACTERISTICS: LENGTH: 326 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION 1...326 (xi) SEQUENCE DESCRIPTION: SEQ ID N0:852 Val Leu Met Ala Leu Unk Asp Lys Arg Tyr Gly Leu Glu Ala Gly Ile 1 5 10 Lys Tyr Phe Thr Met Gly Ala Met Ala Ser Ala Phe Phe Ala Met Gly 25 Ala Met Ala Phe Tyr Leu Leu Thr Gly Ser Leu Asn Leu Glu Val Ile 40 Thr Leu Tyr Leu His Thr Glu Gly Ile Thr Asn Pro Met Leu Phe Ala 55 Met Gly Thr Ile Phe Leu Ile Gly Ala Ile Gly Phe Lys Val Ser Leu 70 75 Val Pro Phe His Thr Trp Met Pro Asp Val Tyr Glu Gly Asn Asn Pro 90 Val Phe Ala Ser Tyr Ile Ser Ile Val Pro Lys Ile Ala Gly Phe Val 100 105 110 Val Ala Thr Arg Leu Phe Gly Ala Phe Ile Asp Thr His Thr Ala Trp 115 120 125 Val Glu Asp Ile Phe Tyr Val Leu Ile Leu Met Thr Ile Thr le Pro 130 135 140 n Phe Ile Ala Leu Trp Gln Glu Asp Val Lys Arg Met Leu Ala Tyr 150 155 160 U T n POT/US 9 6 U9 ip£ANUS lu-Q ,96 Ser Thr Phe Glu Gly 225 Val Phe Val Trp Ala 305 Ser Ser Glu Thr Lys 210 Leu Phe Leu Val Leu 290 Lys Leu Ile Asp Tyr 195 Thr Ile Gly Ala Met 275 Val Thr Leu Ser Ser 180 Ile Trp Lys Leu Val 260 Leu Ala Ile Pro His 165 Gln Gly Asp Thr Ala 245 Glu Val Met Phe Trp 325 Ser Gin Ala Glu His 230 Gly Ser Asn Phe Thr 310 Arg Gly Ala Phe Arg 215 Pro Ile Ala Ser Phe 295 Pro Phe Met Gly 200 Tyr Leu Pro Leu Ala 280 Asn Lys Ala Phe 185 Leu Asp Val Pro Glu 265 Val Lys Thr Leu 170 Val Leu His Ala Phe 250 Ser Ala Pro Pro Ala Tyr Trp Pro Ile 235 Ser Asn Ala Leu Pro 315 Cys Trp Leu Tyr 220 Leu Val His Phe Gin 300 Cys Val Phe Leu 205 Ser Gly Phe Ile Tyr 285 Thr Pro Phe Met 190 Lys Lys Ala Trp Leu 270 Tyr Gin Phe Ile 175 Phe Ser Phe Ile Gly 255 Leu Phe Ser Met His Ala Arg Asn Phe 240 Lys Ala Arg Tyr Arg 320 INFORMATION FOR SEQ ID NO:852: SEQUENCE CHARACTERISTICS: LENGTH: 326 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...326 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:852 Val Leu Met Ala Leu Unk Asp Lys 1 Lys Ala Thr Met Val Val Val Val sn r Tyr Met Leu Gly Pro Phe Ala Glu 130 Phe Ser Thr Phe Leu Ile His Ser 100 Arg Ile Ala Ser 5 Met Tyr His Phe Thr Tyr Leu Phe Leu His Gly Leu Thr Leu 70 Trp Ile Phe Tyr Trp 150 Ser Ala Leu Glu 55 Ile Met Ser Gly Val 135 Gin Gly Met Thr Gly Gly Pro Ile Ala 120 Leu Glu Phe Arg Ala 25 Gly Ile Ala Asp Va 1 105 Phe Ile Asp Ala Tyr Gly 10 Ser Ala Ser Leu Thr Asn Ile Gly 75 Val Tyr 90 Pro Lys Ile Asp Leu Met Val Lys 155 Leu Ala Leu Glu Ala Gly Ile Phe Asn Pro Phe Glu Ile Thr Thr 140 Arg Cys Phe Leu Met Lys Gly Ala His 125 Ile Met Val Ala Met Glu Val Leu Phe Val Ser Asn Asn Gly Phe 110 Thr Ala Thr Ile Leu Ala Phe Ile Gly Ile Ala Leu Pro Val Trp Pro Tyr 160 His F~~L 9/091, Thr Phe G lu Gly 225 Val1 Phe Val1 Trp Ala 305 Se r 0 1u Thr Lys 210 Lau Phe Lau Val1 Leu 290 Lys Leu 165 Asp'Ser Gln 180 Tyr lie Gly 195 Thr Trp Asp Il.e Lys Thr Gly Leu Ala 245 Ala Val Glu 260 Met Leu Val 275 Val. Ala Met Thr Ile Ph.
Leu Pro Trp 325 Gin Ala Clu His 230 Gly Ser An Phe Thr 310 Arg Ala Ph.
Arg 215 Pro Ile Ala Sor Ph.
295 Pro Met Gly 200 Tyr Leu Pro Leu Ala 280 An Lys Ph.
185 A~u Asp Val1 Pro Glu 265 Val Lys Thr 170 Val1 Leu His Ala Ph.
250 Ser Ala Pro Pro Tyr Trp Pro Ile 235 Ser As n Ala Lou Pro 315 Trp Lau 220 Lau Val1 His Ph.
Gln 300 Cys Phe Leu 205 Se r G ly Ph.
I le Tyr 285 Thr Pro 175 Ph.
S. r Ph.
Ile Gly 255 Leu Ph.
Ser Met Ala Arg As n ?he 240 Lys Ala Arg Arg 320 INFORMATION FOR SEQ ID NO:853: SEQUENCE CHARACTERISTICS: LENGTH: 179 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc...eatur.
LOCATION 1 179 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:853 Met Ann Tyr Pro Asn Lou Pro Asn Sor Ala Lou Unk 1 Pro Ala Lys Lys Leu Arg Val1 Lys S. r 145 Glu Leu Cys An Thr Ph.
Thr Unk 130 Tyr Thr Val Arg Ile Ala An Ph.
Asn 115 Leu Gin Lys Lys Ser Val An Ala Ser 100 Thr Glu Ile Asn Glu An Arg Glu Gly Glu Leu An Ph.
Lys 165 An Ph.
40 Glu Ser Lau Thr Asn 120 Ile Gin Ser Giu 25 5cr ValI Sor Lys Sor 105 Ala G iu Ala Leu Lou Glu Lau Lou Lou 90 Met C iu Thr Arg O iu 170 Lou Gln Lou Arg 75 Lys His Asn Thr Asp 155 Ala Lys Val1 Ser An Met Ala Ile Thn 140 As n Ile Ile Gin Glu Lau Ser Lys An Lys 125 Arg Ala Thr 5cr Lau Lou Asp Ile GlU C lu 110 Sor Lou As n Gln Glu is Gin Sor Ph.
O lu Tyr Gln Unk Lou As n Ala 175 Gin An Lou Ph* Trp Giu Glu Ile Thr Gin 160 Lys AMlED01 RT PCT/US 9 6 91 IP&A/tJSiou$ u-j o 710 Asn Asn Ser INFORMATION FOR SEQ ID NO:854: SEQUENCE CHARACTERISTICS: LENGTH: 240 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...240 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:854 Met lie Asn Ser Lys Lys Ser Leu Lys 1 Lys Ile Ser Gly Val Val Leu Ala Lys Pro Arg Ile Lys Ala Asn Ile 130 Ile Glu 145 Thr Tyr Val Lys Thr Arg Ser Arg 210 Glu Lys 225 Leu Phe Phe Tyr Glu Asp Tyr 115 Lys His Ala Gln Gly 195 Val His Lys Gly Gly Pro Thr Ala 100 Glu Gly Asp Tyr Unk 180 Arg Arg Pro 5 Asp Arg Leu Glu Thr Gly Lys Arg 70 Lys Arg Leu Ile Cys Glu Leu Leu Gin Gly 150 Pro Gly 165 Ser Unk Arg Trp Gly Lys Leu Pro 230 Asn Ile Arg 55 Phe Ala Asn Leu His 135 Thr Gly Asn Asn Gly 215 Gin Gly Ala 40 Arg Ile Ile Asn Asp 120 Leu Ile Unk Leu Pro 200 Asp Thr Ala 25 Lys Gin Pro Glu Ala 105 Asp Thr Ile Val Arg 185 Gly Lys Lys 10 His Ala Glu Leu Thr 90 Gly Trp Arg Asn Tyr 170 Ala Cys Pro Gly Leu Arg Gly Phe Phe Asn Cys 75 Ile Leu Glu Leu Leu 155 Gly Asp Val Lys Ser Leu Leu Phe Phe Ala Val Ile 140 Gly Ala Val Ala Pro 220 Cys Gin Gin Asp Ser Leu Met 125 Leu Ser Ser Ala Lys 205 Lys Gly Lys Lys Leu Met Gly 110 Ile Pro Ile Lys Gly 190 Pro Ser Phe Ala Asn Leu Gln Thr Leu Asp Ser Ala Ala 175 Thr Lys Gly Phe Thr His Gin Asn Asp Asn Thr Met Gly 160 Unk Asn Val Tyr Gly 240 Thr Arg Gin Gly Leu Thr Ser 235 INFORMATION FOR SEQ ID NO:854: SEQUENCE CHARACTERISTICS: LENGTH: 240 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein 091 2 2.
IPEMAJS 18DEC1996 (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_£feature LOCATION 1...240 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:854 Met Ile Asn Ser Lys Lys Ser Leu Lys 1 Lys Ser Val Leu Lys Arg Lys Asn Ile 145 Thr Va 1 Thr Ser Glu 225 Ile Gly Val Ala Pro Ile Ala lie 130 Glu Tyr Lys Arg Arg 210 Lys Leu Phe Phe Tyr Glu Asp Tyr 115 Lys His Ala Gin Gly 195 Val His Lys Gly Gly Pro Thr Ala 100 Glu Gly Asp Tyr Unk 180 Arg Arg Pro Asp Leu Thr Lys Lys Leu Cys Leu Gin Pro 165 Ser Arg Gly Leou Arg Glu Gly Arg 70 Arg Ile Glu Leu Gly 150 Gly Unk Trp Lys Pro 230 Asn Ile Arg 55 Phe Ala Asn Leu His 135 Thr Gly Asn Asn Gly 215 Gin Gly Ala 40 Arg Ile Ile Asn Asp 120 Leu Ile Unk Leu Pro 200 Asp Thr Gly Leu Arg Phe Ser Cys Phe Leu Gin Asn Leu Gin Cys Phe Asp Ile Phe Ser Leu Ala Leu Glu Val Met 125 Leu Ile Leu 140 Leu Gly Ser 155 Gly Ala Ser Asp Val Ala Val Ala Lys 205 Lys Pro Lys 220 Gin Gly Leu 235 INFORMATION FOR SEQ ID NO:855: SEQUENCE CHARACTERISTICS: LENGTH: 160 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1....60 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:855 Phe Ala Thr Asp Ser Ser Ser Phe Ser Met Gly Leu Thr Met Ala 10 °CT/US 96/09122 IPENJS 18 DEC1996 712 Ser Ala Tyr Glu Pro Ile Ser Gly Ser Gin Lys Pro Ile Val Gly Gin 25 Ala Leu Leu Leu Leu Ala Ile Leu Ile Leu Leu Asp Leu Ser Phe His 40 His Gln Ile Ile Leu Phe Val Asp His Ser Leu Lys Ala Val Pro Leu 55 Gly Arg Phe Val Phe Giu Pro Glu Leu Ala Lys Asn Ile Val Lys Ala 70 75 Phe Ser His Leu Phe Val Ile Gly Phe Ser Met Ala Phe Pro Ile Leu 90 Cys Leu Val Leu Leu Ser Asp Ile Ile Phe Gly Met Ile Met Lys Thr 100 105 110 His Pro Gln Phe Asn Leu Leu Ala Ile Gly Phe Pro Val Lys Ile Ala 115 120 125 Ile Gly Phe Val Gly Ile Ile Leu Ile Ala Ser Ala Ile Met Gly Arg 130 135 140 Phe Lys Glu Glu lile Ser Leu Ala Phe Ser Val Ile Ser Lys Ile Phe 145 150 155 160 INFORMATION FOR SEQ ID NO:856: SEQUENCE CHARACTERISTICS: LENGTH: 94 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION 1...94 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:856 Met Tyr Gly Val Lys Glu Ile Lys Asp Lys Ile Asp Lys Gln Leu His 1 5 10 Asn Asn Asp His Leu Phe Glu Gly Leu Phe Gly Glu Lys Glu Asp Leu 25 Lys Lys Leu Val Ser Met Phe Gly Gln Leu Arg Phe Gln Lys Arg Trp 40 Ser Gln Thr Pro Arg Val Pro Gln Thr Ser Val Leu Gly His Thr Leu 55 Cys Val Ala Ile Met Gly Tyr Leu Leu Ser Phe Asp Leu Lys Ala Cys 70 75 Lys Ser Met Arg Ile Asn His Phe Leu Gly Gly Leu Phe Pro INFORMATION FOR SEQ ID N0:857: SEQUENCE CHARACTERISTICS: LENGTH: 146 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES Amncnf PUT/US 96/09 122 IPEAUS 18 DECi 3 713 (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...146 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:857 Met Thr Leu Asp Asp Leu Leu Gly Gly Ser Leu Asp Pro His Cys Phe 1 5 10 Cys Lys Pro Leu lle Lys Thr Lys Lys Asp Gln Glu Arg Leu Leu Ser 25 Leu Ala Leu Lys Ala His Pro Lys Ile Ser Phe Gly Lys Asp Ser Ala 40 Pro His Phe Ile Ser Lys Lys His Ser Ala Asn Ile Pro Ala Gly Ile 55 Phe Ser Ala Pro Ile Leu Leu Pro Ala Leu Cys Glu Leu Phe Glu Lys 70 75 His Asn Ala Leu Glu Asn Leu Gln Ala Phe Ile Ser Asp Asn Ala Lys 90 Lys Ile Tyr Ala Leu Asp Asn Leu Pro Ser Lys Lys Ala His Leu Ser 100 105 110 Lys Lys Pro Phe Ile Val Pro Thr His Thr Leu Cys Leu Asn Glu Lys 115 120 125 Ile Ala Ile Leu Arg Gly Gly Glu Thr Leu Ser Trp Asn Lau Gln Glu 130 135 140 Ile Ala 145 INFORMATION FOR SEQ ID NO:858: SEQUENCE CHARACTERISTICS: LENGTH: 204 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION 1...204 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:858 Val Ser Gly Val Val Leu Ser Lys Phe Asp Ser Asp Ser Lys Gly Gly 1 5 10 Ile Ala Leu Gly Ile Thr Tyr Gln Leu Gly Leu Pro Leu Arg Phe Ile 25 Gly Ser Gly Glu Lys Ile Pro Asp Leu Asp Val Phe Met Pro Glu Arg 40 Ile Val Gly Arg Leu Met Gly Ala Gly Asp Ile Ile Ser Leu Ala Glu 55 Lys Thr Ala Ser Val Leu Asn Pro Asn Glu Ala Lys Asp Leu Ser Lys 70 75 Lys Leu Lys Lys Gly Gln Phe Thr Phe Asn Asp Phe Leu Asn Gln Ile 90 Glu Lys Val Lys Lys Leu Gly Ser Met Ser Ser Leu Ile Ser Met Ile 100 105 110 AMENDED SHEET PCT/US 96/09122 IPENUSI 96 Pro Ser Lys 145 Arg Ile Lys Gly Ser 130 Lys Ile Lys Lys Leq Gly 115' Leu Glu Glu Arg Ala Leu Arg Phe 180 Gly Ile 195 Asn Val Glu Gly 165 Asp Ser Met Lys Asn 150 Unk Gin Asp Ser 120 Ile Glu Leu Ser Met 200 Leu Ala Leu Unk 170 Met Leu 714 Lys As Met Va 14 Asn G] 155 Unk G: Ala L) Unk Ur INFORMATION FOR SEQ ID NO:858: SEQUENCE CHARACTERISTICS: LENGTH: 204 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii, HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...204 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:858 Val Ser Gly Val Val Leu Ser Lys Phe Asp Ser 1 Ile Ala Gly Ser Ile Val Lys Thr Lys Leu Glu Lys Pro Gly Ser Ser 130 Lys Lys 145 Arg Ile Ile Lys Lys Lys Leu Gly Gly Ala Lys Val Leu 115 Leu Glu Ala Arg Gly 195 Gly Glu Arg Ser Lys Lys 100 Gly Glu Arg Leu Phe 180 Ile 5 lle Lys Leu Val Gly Lys Asn Val Glu Gly 165 Asp Ser Thr le Met Leu 70 Gin Leu Met Lys Asn 150 Unk Gin Asp Tyr Pro Gly 55 Asn Phe Gly Ala Lys 135 Pro Gly Ala Leu Gin Asp 40 Ala Pro Thr Ser Ser 120 Ile Glu Leu Ser Met 200 Leu 25 Leu Gly Asn Phe Met 105 Ala Lys lie Glu Lys 185 Asn 10 Gly Asp Asp Glu Asn 90 Ser Leu Ala Leu Unk 170 Met Leu Leu Val Ile Ala 75 Asp Ser Lys Met Asn 155 Unk Ala Unk Asp Pro Phe Ile Lys Phe Leu Asp Val 140 Gly Glu Lys Unk Ser Leu Met Ser Asp Leu Ile Thr 125 Asn Ser Ile Arg Lys Arg Pro Leu Leou Asn Ser 110 Asp Ser Arg Asn Leu 190 Gly Phe Glu Ala Ser Gin Met Leu Met Arg Arg 175 Thr Gly Ile Arg Glu Lys Ile Ile Glu Thr Lys 160 Ile Asn INFORMATION FOR SEQ ID NO:859: SEQUENCE CHARACTERISTICS:
S.
I PEAUS 1 8 DEC 96 715 LENGTH: 173 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...173 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:859 Met Gly Val Leu Gly Met Phe Ala Phe Phe Ser Trp Val Phe Leu Phe 1 5 10 Lys His Asn Leu Ser His Lys Ile Arg Leu Tyr His Glu Lys Lys Asp 25 Phe Asp Lys Leu Leu Lys Gin Ile Leu Ser Gin Asp Thr Gin Lys Thr 40 Phe Leu Lys Thr Lys Phe Lys Ser Asp Leu Ala Lys Asn Leu Ser Gin 55 Ile Leu Ala Arg Tyr Asp Leu Lys Ala Asp Leu Asn Thr Pro Asn Ser 70 75 Gly Cys Glu Lys Val Asp Asn Leu Phe Lys His Tyr His Asn Ile Glu 90 Asn Asn Thr Leu Glu Pro Lys Asp His Ala Lys His Ser Leu Ala Tyr 100 105 110 Glu His Ala Tyr Phe Ser Lys Arg Leu Lys Ala Phe Ile His Asn Asp 115 120 .125 Leu Lys Asn Ala Phe Glu Val Leu Thr Asn Ala Gin Ile Pro Leu Glu 130 135 140 Leu Arg Arg Tyr Ala Tyr Arg Asn Arg Pro Lys Arg Gin Gin Lys Arg 145 150 155 160 Gly Phe Lys Gly Cys Glu Cys Asp Ala Arg Gly Phe Gly 165 170 INFORMATION FOR SEQ ID NO:860: SEQUENCE CHARACTERISTICS: LENGTH: 193 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc.feature LOCATION 1...193 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:860 Val Ser Val Pro Ala Thr Ser Ala Asn Leu Gly Pro Gly Phe Asp Cys 1 5 10 Leu Gly Leu Ser Leu Asn Leu Arg Asn Arg Phe Phe Ile Glu Pro Ser 25 T S 9 09122 rPF& S 18DEC1996 716 Asn Ile His Ala Val Lys Leu Val Gly GIu Gly Glu Gly lie Pro Lys 40 Phe Leu Thr Asn Asn Ile Phe Thr Lys Val Phe Tyr Glu Ile Leu Lys 55 Lys His Gly Asn Asp Gly Ser Phe Lys Phe Leu Leu His Asn Lys Val 70 75 Pro Ile Thr Arg Gly Met Gly Ser Ser Ser Ala Met Ile Val Gly Ala 90 Val Ala Ser Ala Phe Ala Phe Leu Gly Phe Ala Phe Asp Arg Glu Asn 100 105 110 Ile Leu Asn Thr Ala Leu Ile Tyr Glu Asn His Pro Asp Asn Ile Thr 115 120 125 Pro Ala Val Phe Gly Gly Tyr Asn Ala Ala Phe Val Glu Lys Lys Lys 130 135 140 Val Ile Ser Leu Lys Thr Lys Ile Pro Ser Phe Leu Lys Ala Val Met 145 150 155 160 Val Ile Pro Asn Arg Val Ile Ser Thr Lys Gln Ser Arg His Leu Cys 165 170 175 Pro Ser Val Thr Ala Cys Lys Lys Ala Cys Leu Thr Phe Arg Met Arg 180 185 190 Val INFORMATION FOR SEQ ID NO:861: SEQUENCE CHARACTERISTICS: LENGTH: 104 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc.feature LOCATION 1...104 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:861 Val Ala Lys Asn Leu Val Ala Ser Gly Val Cys Asp Lys Ala Thr Val 1 5 10 Gin Leu Ala Tyr Ala Ile Gly Val Ile Glu Pro Val Ser Ile Tyr Val 25 Asn Thr His Asn Thr Ser Lys His Ser Ser Ala Glu Leu Glu Lys Cys 40 Val Lys Ser Val Phe Lys Leu Thr Pro Lys Gly Ile Ile Glu Ser Leu 55 Asp Leu Leu Arg Pro Ile Tyr Ser Leu Thr Ser Ala Tyr Gly His Phe 70 75 Gly Arg Glu Leu Glu Glu Phe Thr Trp Glu Lys Thr Asn Lys Val Glu 90 Glu Ile Lys Ala Phe Phe Lys Arg 100 INFORMATION FOR SEQ ID NO:862: SEQUENCE CHARACTERISTICS: LENGTH: 355 amino acids TYPE: amino acid IPEMJSS 18 DEC 1a 717 TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...355 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:862 Val Arg Leu Phe Arg Phe Val Gly Trp Tyr Tyr Phe
I
1 Ile Lys Phe Leu Gin Ser Leu Ile Tyr 145 Lys Ser Leu Ala Asn 225 Val Asn Leu Pro Ile 305 Phe Phe Lys Val Tyr Thr Leu Tyr Pro Asn Tyr 130 Asn Ala Tyr His Asn 210 Phe Ser Ala Pro Ser 290 Ile Ser Phe Arg Leu Ala Tyr Leu Thr Ile Ala 115 Lys Asp Gin Ala Asp 195 Ala Arg .0 Ile Asp Phe 275 Leu Ile Ile Val Leu 355 Leu Asp Asp Ala Ala Phe 100 Thr Asp Asp Asn Glu 180 Thr Leu Pro Thr Thr 260 Phe Ala Thr Ser Phe 340 5 Ala Lys Ile Met Leu Leu Pro Asn Tyr Ile 165 Ala Thr Asn Lys Asp 245 Lys Val Arg Leu Gly 325 Leu Leu Met Leu Val 70 Leu Ile Phe Ser Val 150 Lys Lys Ile Thr Val 230 Ala Lys Pro Tyr Val 310 Ile Ala Glu Pro Phe 55 Leu Ser Ser Val Leu 135 Tyr Val Glu Tyr Thr 215 Leu Leu Val Phe Glu 295 Val Leu Leu Leu Asp 40 Ala Phe Ile Leu Tyr 120 Ser Phe Phe Ala Glu 200 His Asp Leu Arg Leu 280 Asn Trp Ile Ser 10 Phe Phe 25 Ser Ala Leu Asn Tyr Ile Gly Phe 90 Phe Phe 105 Met Glu Val Ser Asp Lys Arg Leu 170 Phe Phe 185 Met Pro Leu Glu Thr Ile Ser Leu 250 Ser Phe 265 Ser Val Leu Ala Gly Leu Pro Glu 330 Leu Trp 345 Val Asn Tyr Thr 75 Ser Thr Glu Glu Ile 155 Lys Glu Leu Thr Tyr 235 His Leu Leu Leu Phe 315 Ile Gly Met Thr I Phe Lys Ala Lys His 140 Asn Asp Asp Ser Phe 220 Gin Ala Tyr Ile Leu 300 Phe Gly Lys Ile Ile Leu Ile Cys Va 1 Thr 125 Leu Pro Lys Lys Phe 205 Lys Asn Leu Val Ala 285 Gly Ala Val Tyr Phe Asp Ser Ile Leu Pro Ile Lys Ser Gin Ile Tyr Val 110 Gin Asn Leu Val Leu Leu Thr Leu 175 Tyr Trp 190 Glu Leu Thr Leu Lys Pro Val Arg 255 Phe Ala 270 Tyr Phe Leu Lys Leu Gly Leu Ser 335 Leu Leu Phe Ser Asn Leu Gly Leu Lys Gin 160 Glu Ile Gly Lys Ala 240 Gin Ile Ser Phe Lys 320 Pro Tyr Phe Lys Lys Leu Asn 350 INFORMATION FOR SEQ ID NO:863: EDITORIAL NOTE NUMBER 63278/96 THIS SPECIFICATION DOES NOT CONTAIN PAGES NUMBERED 718 OR 719.
F&i/uS 960 Ei lPEJV~U$ ±~u&S 720 Ser Unk INFORMATION FOR SEQ ID NO:865: SEQUENCE CHARACTERISTICS: LENGTH: 233 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION 1...233 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:865 Leu Ser Leu Met Unk Val Leu Asn Ala Lys Glu Cys Val Unk 1 Thr Arg Gin Leu Lys Leu Thr Val Ile Lys Leu Thr Lys Gly Ala Phe 130 Glu Glu 145 Arg Glu Thr Leu Gin Glu Glu Trp 210 Pro Ile 225 Ser Gin Val Leu Tyr Leu Val 115 Thr Ser Leou His Gin 195 Ile Lys Val Ser Lys Asn Thr Ile 100 Lys Leu Val Val Asp 180 Gin Ile Ala 5 Lys Tyr Asp Thr Pro Pro Ile Lys Leu Ala 165 Phe Ala Leu Trp Tyr Lys Lys Phe 70 Glu Gly Phe Thr Leu 150 Lys Asp Lys Pro Gin 230 His Met Lys 55 Asp Thr Ala Tyr Leu 135 Lys Asp Ala Val Asn 215 Asn Gln Ala 40 Pro Tyr Trp Leu Ile 120 Lys Glu Tyr lle Leu 200 Ser Lys Gin 25 Lys Ala Ala Asp Asp 105 Ser Ser Lys Ala Phe 185 Gin Leu Lys 10 Ser Met Val Gly Lys 90 Phe Asn Phe Gly Ile 170 Ala Asn Tyr Ala Ala Ile Tyr 75 Phe Leu Arg Lys Lys 155 Val Lys Ala Gly Glu Leu Leu Leu Glu Glu Thr Leu 140 Pro Leu Asp Gin Thr 220 Ile Asp Asp Val Lys Tyr Gin 125 Pro Lys Gin Ala Lys 205 Trp Arg Asn Leu Lys Glu Ala 110 Lys Gin Ala Val Lys 190 Phe Glu Pro Ala Asn Asp Asn Gly Asn Asn Val Val Gly 175 Asn Gly Asp Ile Leu Leu Glu Cys Ser Ser Lys Ser Arg 160 Asp Ser Thr Gly INFORMATION FOR SEQ ID NO:865: SEQUENCE CHARACTERISTICS: LENGTH: 233 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein A (c',rknCMQccT PO/US 9 /E i/ IPEANUS18 OEC 1996 (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION 1...233 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:865 Leu Ser Leu Met Unk Val Leu Asn Ala 1 Thr Arg Gin Leu Lys Leu Thr Val Ile Lys Leu Thr Lys Gly Ala Phe 130 Glu Glu Arg Glu Thr Leu Gin Glu Glu T:? 210 Pro Ile 225 Ser Gin Va 1 Leu Tyr Leu Val 115 Thr Ser Leu His Gin 195 Ile Lys Val Ser Lys Asn Thr Ile 100 Lys Leu Va 1 Val Asp 180 Gin Ile Ala 5 Lys Tyr Asp Thr Pro Pro Ile Lys Leu Ala 165 Phe Ala Leu Trp Tyr Lys Lys Phe 70 Glu Gly Phe Thr Leu 150 Lys Asp Lys Pro Gin 230 His Met Lys 55 Asp Thr Ala Tyr Leu 135 Lys Asp Ala Val Asn 215 Asn Gin Ala 40 Pro Tyr Trp Leu Ile 120 Lys Glu Tyr Ile Leu 200 Ser Lys Gin 25 Lys Ala Ala Asp Asp 105 Ser Ser Lys Ala Phe 185 Gin Leu Lys Lys 10 Ser Met Va 1 Gly Lys 90 Phe Asn Phe Gly Ile 170 Ala Asn Tyr Glu Cys Val Ala Glu Ile Ala Leu Asp Ile Leu Asp Tyr Leu Val 75 Phe Glu Lys Leu Glu Tyr Arg Thr Gin 125 Lys Leu Pro 140 Lys Pro Lys 155 Val Leu Gin Lys Asp Ala Ala Gin Lys 205 Gly Thr Trp 220 Unk Arg Asn Leu Lys Glu Ala 110 Lys Gin Ala Val Lys 190 Phe Glu Pro is Ala Asn Asp Asn Gly Asn Asn Val Val Gly 175 Asn Gly Asp Ile Leu Leu Glu Cys Ser Ser Lys Ser Arg 160 Asp Ser Thr Gly INFORMATION FOR SEQ ID NO:866: SEQUENCE CHARACTERISTICS: LENGTH: 239 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...239 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:866 Met lile Tyr Gly Val Leu Asp Gly Leu Phe Leu Ala Ile Leu Gin Ala 1 5 10 v/ AMConn ;T 8 DEC 1996 Gin Asn Tyr.Arg Phe His Ser Leu Tyr Leu Leu Lys Lys Glu Ile Asp Gin Val 145 Asn Leu Ile Pro Lys 225 Ser Leu Leu Tyr Tyr Gly Thr Pro Phe 165 Gly Lys Ala Met Cys Phe Lys 70 Lys Lys Leu Lys Ser 150 Ile Val Glu Asn Phe 230 Tyr Ile Arg Ser Gin Lys Pro 135 Leu Ile Lys Val Met 215 Met Ala Gly Ile Phe Leu 105 Thr Lys Leu Ser Asp 185 Glu Asn Gly Arg Phe Thr Asn 90 Arg Leu Ile Leu Cys 170 Phe Arg Pro Gly Phe Tyr Phe His 75 Leu Gly Lys Asn Leu 155 Gly Gin Ala Asn Ser 235 Leu Ile Glu Lys Glu Phe Leu Cys Lys Lys 175 Glu Asp Leu Val Asp Lys Leu Leu Asn Glu Tyr Val Glu 160 Pro Arg Thr Ala INFORMATION FOR SEQ ID NO:867: SEQUENCE CHARACTERISTICS: LENGTH: 85 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_£eature LOCATION 1...85 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:867 Met Leu Ala Ala Gly Leu Thr Leu Pro Glu Phe Gly Cys Tyr Leu Ser 1 5 10 His Tyr Leu Leu Trp Lys Glu Cys Val Lys Leu Asp Gln Pro Val Val 25 Ile Leu Glu Asp Asp Val Thr Leu Glu Ser His Phe Met Gin Ala Leu 40 Glu Asp Cys Leu Lys Sea Pro Phe Asp Phe Val Arg Leu Tyr Gly Cys 55 Tyr Trp Tyr Tyr Gln Arg Asp Lys Ile Pro Cys Phe Ala Gin Arg Ile 70 75 Cys Ile Ser Ser Leu INFORMATION FOR SEQ ID NO:867: PCT/US 96/091k IPENUS 18 DEC 1996 723 SEQUENCE CHARACTERISTICS: LENGTH: 85 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...85 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:867 Met Leu Ala Ala Gly Leu Thr Leu Pro Glu Phe Gly Cys Tyr Leu Ser 1 5 10 His Tyr Leu Leu Trp Lys Glu Cys Val Lys Leu Asp Gin Pro Val Val 25 lle Leu Glu Asp Asp Val Thr Leu Glu Ser His Phe Met Gin Ala Leu 40 Glu Asp Cys Leu Lys Ser Pro Phe Asp Phe Val Arg Leu Tyr Gly Cys 55 Tyr Trp Tyr Tyr Gln Arg Asp Lys Ile Pro Cys Phe Ala Gin Arg Ile 70 75 Cys Ile Ser Ser Leu INFORMATION FOR SEQ ID NO:868: SEQUENCE CHARACTERISTICS: LENGTH: 289 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION 1...289 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:868 Met Leu Ala Phe Leu Lys Thr Pro Arg Asn Ser Ala Phe Ala Leu Gly 1 5 10 Ile Phe Val Gly Ala Leu Leu Phe Tyr Trp Cys Ala Lou Arg Lou Ser 25 His Ser Asp Phe Thr Tyr Leu Leu Pro Leu Ile Ile Val Leu Val Ala 40 Leu Val Tyr Gly Val Leu Phe Tyr Leu Leu Leu Tyr Phe Glu Asn Pro 55 Tyr Phe Arg Leu Leu Ser Phe Leu Gly Ser Ser Phe Ile His Pro Phe 70 75 Gly Phe Asp Trp Leu Val Pro Asp Ser Phe Phe Ser Tyr Ser Val Phe 90 AMENDED SHEET 724 Arg Val Asp Lys Leu Ser Leu Gly Leu lie Phe Leu Ala Cys Ile Phe 100 105 110 Leu Ser Ala Gin Asn Leu Lys Lys Tyr Arg Met Ile Gly Val Leu Leu 115 120 125 Leu Leu Gly Ala Leu Asp Phe His Phe Phe Lys Ile Ser Asp Leu Lys 130 135 140 Glu Val Gly Asn Ile Glu Leu Val Ser Thr Arg Thr Pro Gin Asp Leu 145 150 155 160 Lys Phe Asp Ser Asn Tyr Leu Asn Asn Ile Glu Asn Asn Ile Leu Lys 165 170 175 Glu Ile Lys Leu Ala Gln Ser Lys Gin Lys Thr Leu Ile Val Phe Pro 180 185 190 Glu Thr Ala Tyr Pro Ile Ala Leu Glu Asn Ser Pro Phe Lys Thr Gin 195 200 205 Leu Glu Asp Leu Ser Asp Lys Ile Ala Ile Leu Ile Gly Thr Leu Arg 210 215 220 Ala Gln Gly Tyr Ser Leu Tyr Asn Ser Ser Phe Leu Phe Ser Lys Lys 225 230 235 240 Ser Val Gin Ile Ala Asp Lys Val Ile Leu Ala Pro Phe Gly Glu Ile 245 250 255 Met Pro Leu Pro Glu Phe Leu Gin Lys Pro Leu Glu Lys Leu Phe Phe 260 265 270 Ala Arg Ala Leu Ile Tyr Thr Ala Thr Leu Pro Ile Ser Ala Ile Leu 275 280 285 His INFORMATION FOR SEQ ID NO:869: SEQUENCE CHARACTERISTICS: LENGTH: 436 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION 1...436 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:869 Met Asn Asp Pro Lys His Val Val Tyr Val Trp Leu Asp Ala Leu Leu 1 5 10 Asn Tyr Ala Ser Ala Leu Gly Tyr Leu Asn Gly Leu Asp Asn Lys Met 25 Ala His Phe Glu Arg Ala Arg His Ile Val Gly Lys Asp Ile Leu Arg 40 Phe His Ala Ile Tyr Trp Pro Ala Phe Leu Met Ser Leu Asn Leu Pro 55 Leu Phe Lys Gin Leu Cys Val His Gly Trp Trp Thr Ile Glu Gly Val 70 75 Lys Met Ser Lys Ser Leu Gly Asn Val Leu Asp Ala Gin Lys Leu Ala 90 Met Glu Tyr Gly Ile Glu Glu Leu Arg Tyr Phe Leu Leu Arg Glu Val 100 105 110 Pro Phe Gly Gin Asp Gly Asp Phe Ser Lys Lys Ala Leu Val Glu Arg 115 120 125 ale Asn Ala Asn Leu Asn Asn Asp Leu Gly Asn Leu Leu Asn Arg Leu AgvJcn cMCrT IPF JS1 8 DEC 1996 Leu 145 Ile Asp Glu Glu Ala 225 Leu Arg Lys Ile Glu 305 Glu Lys Glu Arg Ser 385 Lys Asn Ser 130 Gly Thr Asn Glu Glu 210 Leu Tyr Val Leu Glu 290 Lys Lys Lys Lys Leu 370 Leu Leu Asp Leu Met Ala Ala Leu 195 Pro Leu Ala Glu Gin 275 Lys Gly Ala Val Ser 355 Arg Val Met Asn Ile 435 Ala Tyr Asn 180 Phe Trp Ser Phe Ile 260 Asp le Glu Pro Glu 340 Asn Gin Gly Gly Leu 420 Ser Lys Tyr 165 Ser Asn Val Leu Met 245 Thr Met Glu Glu Pro 325 Ile Lys Ile Gin Glu 405 Ala Phe Glu Pro Asp 200 Lys Asn Ser Asn Gin 280 Glu Ala Glu Gly Arg 360 Gly Cys Glu Ser Asn Leu Lys 185 Phe Asn Thr Ala Tyr 265 Asp Lys Glu Asn Leu 345 Leu Ile Val Gly Pro 425 Tyr Glu 170 Met Leu Asn Leu Met 250 Glu Thr Ile Lys Tyr 330 Ile Lys Ala Val Met 410 Thr Ser 155 Lys Gin Asn Glu Leu 235 Lys Arg Glu Glu Ala 315 Ile Lys Val Leu Ala 395 Ile Arg 140 Leu Ala Leu Lys Ser 220 Gin Leu Phe Pro Lys 300 Glu Ser Glu Asp Asp 380 Asn Leu Glu Lys His His Leu 205 Glu Ser Ala Phe Leu 285 Ile Lys Ile Ala Leu 365 Tyr Leu Ala Lys Ser Gin Lys 190 Ile Lys Ser Ser Lys 270 Phe Glu Lys Glu Gin 350 Gly Glu Lys Val Ile 430 Thr 'le 175 Ala Ala Leu Phe Ala 255 Ala Ser Lys Glu Asp 335 Arg Glu Pro Pro Arg 415 Ala Lys 160 Leu Leu Lys Glu Leu 240 Phe Lys Lys Ile Lys 320 Phe Ile Asn Glu Ala 400 Asp Gly INFORMATION FOR SEQ ID NO:870: SEQUENCE CHARACTERISTICS: LENGTH: 114 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION 1...114 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:870 Met Lys Arg Pro Ile Ser Lys Leu Lys Gin Asn Phe Leu Gin Phe Lys 1 5 10 His Ser Phe Asn Lys His Leu Asp Lys Tyr Ser Leu Tyr Tyr Arg Leu 25 u AMIInFn qHFFr PCT/US 9 6 09 122 iPEMA S 18 DEC 1996 726 Phe Asn Ile.Ser Ser Ile Val lie Gly Phe Leu Ile Ala Leu Phe Ser 40 Tyr Gly Ala Gly Val Ile Lau Val Tyr Pro Ile Leu Phe Leu Phe Ala 55 Leu Ile Ile Lys Pro Ser Phe Phe Tyr Tyr Thr Thr Tyr Leu Leu Leu 70 75 Leu Val Ser Leu Ser Ile Ile Ser Lys Tyr Tyr Leu Leu Ser His Ala 90 Asn Phe Thr Met Lys Leu Ile Met Leu Met Thr Gin Trp Gin Asn Trp 100 105 110 Phe Leu INFORMATION FOR SEQ ID NO:871: SEQUENCE CHARACTERISTICS: LENGTH: 173 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc feature LOCATION 1...173 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:871 Met Gly Phe Glu Lys Ser Ile Leu Asp Asn Leu Asn Gly Ala Gin Lys 1 5 10 Ile Val Ala Cys His Ile Gin Gly Pro Leu Leu Ile Leu Ala Gly Ala 25 Gly Ser Gly Lys Thr Lys Thr Leu Thr Ser Arg Leu Ala Tyr Leu Ile 40 Gly Ala Cys Gly Val Pro Ser Glu Asn Thr Leu Thr Leu Thr Phe Thr 55 Asn Lys Ala Ser Lys Glu Met Gin Glu Arg Ala Leu Lys Leu Leu Lys 70 75 Asn Gln Ala Leu Ile Pro Pro Leu Leu Cys Thr Phe His Arg Phe Gly 90 Leu Leu Phe Lou Arg Gin His Met Asn Leu Leu Lys Arg Ala Cys Asp 100 105 110 Phe Ser Val Lou Asp Ser Asp Glu Val Lys Thr Leu Cys Lys Gin Leu 115 120 125 Lys Ile Ser Asn Phe Arg Ala Ser Ile Ser Gin Ile Lys Asn Gly Met 130 135 140 Met Asp Leu Ser Val Gln Asp Ser Glu Cys Tyr Lys Ala Tyr Glu Leu 145 150 155 160 Tyr Gin Asn Ala Leu Lys Lys Asp Asn Leu Val Glu Phe 165 170 INFORMATION FOR SEQ ID NO:872: SEQUENCE CHARACTERISTICS: LENGTH: 115 amino acids TYPE: amino acid IN TOPOLOGY: linear A 4st-neS LuCC7 IPE JS 18 8DEC 1996 727 (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc feature LOCATION 1...115 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:872 Leu Ile Ala Lau Arg Val Thr Ala Trp Lys Val Unk Ala Met Lys Arg 1 5 10 Leu His Leu Ser Val Lys Asp Ala Glu Asn Phe Asp Ala Ile Leu Arg 25 Glu Arg Pro Phe Phe Lys Asp Leu Ile Glu Phe Met Val Ser Gly Pro 40 Val Val Val Met Val Leu Glu Gly Lys Asp Ala Val Ala Lys Asn Arg 55 Glu Leu Met Gly Ala Thr Asp Pro Lys Leu Ala Gln Lys Gly Thr Ile 70 75 Arg Ala Asp Phe Ala Glu Ser Ile Asp Ala Asn Ala Val His Gly Ser 90 Asp Ser Leu Glu Asn Ala His Asn Glu Ile Ala Phe Phe Phe Ala Ala 100 105 110 Arg Glu Phe 115 INFORMATION FOR SEQ ID NO:872: SEQUENCE CHARACTERISTICS: LENGTH: 115 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION 1...115 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:872 Leu Ile Ala Leu Arg Val Thr Ala Trp Lys Val Unk Ala Met Lys Arg 1 5 10 Leu His Leu Ser Val Lys Asp Ala Glu Asn Phe Asp Ala Ile Leu Arg 25 Glu Arg Pro Phe Phe Lys Asp Leu Ile Glu Phe Met Val Ser Gly Pro 40 Val Val Val Met Val Leu Glu Gly Lys Asp Ala Val Ala Lys Asn Arg 55 Glu Leu Met Gly Ala Thr Asp Pro Lys Leu Ala Gln Lys Gly Thr Ile 70 75 Arg Ala Asp Phe Ala Glu Ser -le Asp Ala Asn Ala Val His Gly Ser 90 Asp Ser Leu Glu Asn Ala His Asn Glu Ile Ala Phe Phe Phe Ala Ala 100 105 110 AMENDED SHEET PCT/US 9 6 q 12.2 72 PEANUS 18 DoC996 728 Arg Glu Phe 115 INFORMATION FOR SEQ ID NO:873: SEQUENCE CHARACTERISTICS: LENGTH: 127 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION .127 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:873 Val Phe Thr Tyr Ser Leu Gly Gin Val Phe Phe Ser Leu Ser Ile Gly 1 5 10 Leu Gly Ile Asn Ile Thr Tyr Ala Ala Val Thr Asp Lys Thr Gin Asn 25 Leu Leu Lys Ser Thr Ile Trp Val Val Leu Ser Gly Ile Leu Ile Ser 40 Leu Val Unk Gly Leu Met Ile Phe Thr Phe Val Phe Glu Tyr Gly Ala 55 Asn Val Ser Gin Gly Thr Gly Leu Ile Phe Thr Ser Leu Pro Val Val 70 75 Phe Gly Gin Met Gly Ala Ile Gly Val Pro Cys Phe Asn Ser Phe Leu 90 Ala Arg Ala Arg Phe Cys Trp His His Phe Tyr Gly Gly Phe Ile Arg 100 105 110 Ala Lys Arg Asp Val Ser Tyr Arg Lys Val Ser Ile Leu Ser Phe 115 120 125 INFORMATION FOR SEQ ID NO:874: SEQUENCE CHARACTERISTICS: LENGTH: 150 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...150 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:874 Met Lys Pro Leu His Phe Ser His Leu Asp Arg Glu Gin Ser Gly Asp 1 5 10 \Val Gly Phe Ile Ile Lys Asn Leu Ile Phe Leu Gly val Phe Ser Leu PGT/ub 96 09 729 25 Leu Gly Trp Leu Asn Thr Glu Tyr Phe Leu Trp Pro Ser Met Leu Glu 40 Leu Lys Lys Ile Leu Leu Glu Glu Asn Arg Lys Lys Ser Val Leu Glu 55 Tyr Ala Gin Arg His Phe Glu Thr Ala Leu Ala Asn Tyr Arg Asn Gin 70 75 Lys Glu Thr Ser Glu Ser Leu Leu Lys lie Phe Asn Asp Glu Glu Ser 90 Arg Arg Ile Leu Glu Lys Ile Leu Lys Lys Cys Phe Asp Ala Tyr Lys 100 105 110 Ile Lys Pro Leu Leu Ser Gln Asn Pro Ser Gln Lys Thr Gln Phe Phe 115 120 125 Ile Met Ala Arg Ala Ser Glu Leu Glu Lys Thr Tyr Leu Phe Phe Thr 130 135 140 Leu Ile Asn Lys Tyr Leu 145 150 INFORMATION FOR SEQ ID NO:875: SEQUENCE CHARACTERISTICS: LENGTH: 209 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION 1...209 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:875 Met Asn Ala Leu Lys Arg Ala Cys Leu Arg Leu Met Gly Glu Thr Asn 1 5 10 Thr Asp Asp Leu Unk Pro Unk Ser Asp Ala Phe Thr Arg Ser Asp Ile 25 Pro Leu His Ala Lys Ala Met Leu Lys Asn Arg Ile Glu Asn Tyr Glu 40 Gin Arg Ile Glu Ala Ile Lys Thr Lys Gly Val Pro Val Ala Tyr Val 55 Gly Asp Val Val Gly Thr Gly Ser Ser Arg Lys Ser Ala Thr Asn Ser 70 75 Ile Met Trp His Phe Gly Lys Asp Ile Pro Phe Val Pro Asn Lys Arg 90 Ser Gly Gly Ile Val Ile Gly Gly Val Ile Ala Pro Ile Phe Phe Ala 100 105 110 Thr Cys Glu Asp Ser Gly Ala Leu Pro Ile Val Ala Asp Val Lys Asp 115 120 125 Leu Lys Glu Gly Asp Ile Ile Lys Ile Tyr Pro Tyr Lys Gly Glu Ile 130 135 140 Thr Leu Asn Asp Lys Val Val Ser Thr Phe Lys Leu Glu Pro Glu Thr 145 150 155 160 Leu Leu Asp Giu Val Arg Ala Ser Gly Arg Ile Pro Lou Ile Ile Gly 165 170 175 Arg Gly Leu Thr Asn Lys Ala Arg Lys Phe Leu Gly Arg Arg Ile Gly 180 185 190 Ser Val Gln Lys Thr Phe Arg Pro Ser Ser Ala Leu Arg Lou His Phe 195 200 205 AN~C~ POT/US 9 6/09 122 IPEUS 18 DEC 1996 730 Ala INFORMATION FOR SEQ ID NO:876: SEQUENCE CHARACTERISTICS: LENGTH: 234 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...234 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:876 Met Leu Ser Ala His Gln Pro Phe Lys Asn Tyr Pro 1 Lys Pro Ser Ser Ile Ser Lys Glu Cys 145 Met Leu Lys Ala His 225 Glu Ala Leu His Val Val Lys Glu 130 Thr Gly Arg Val Leu 210 Leu Leu Met Phe Asn Pro Phe Ala 115 Leu Phe Leu Lys Leou 195 Ile Ile 5 Gin Glu Cys Asp Ser Arg Val Phe Gly Leu Val Pro 100 Lys Ala Leu Lys Tyr Gly His Val 165 Val Leu 180 Pro Leu Gly Leu Ala Ile His Gly Asp Asp 70 Leu Ser Arg Val Thr 150 Ala Val Ala Met Ala 230 Asn Ile Val 55 Gly Ile Gly Gin Glu 135 Ala Asn Glu Lys Ala 215 Asp Ala Thr 40 Ile Ala Gly Pro Asp 120 Met Asn Ser Glu Leu 200 Thr Leu Tyr 25 Gin Ala Phe Ala Met 105 Phe Gin Ser Ser Ser 185 Ile Gly Val 10 Ala Gly Leu Phe Leu 90 Val Ala Ser Asn Phe 170 Ala Asp Gly Gly Ser Tyr Ser Leu 75 Ser Ser Met Tyr Gin 155 Ile Lys Glu Ser Val Glu Thr Gly Phe Gly Gly His 140 Met Asn Arg Lys Thr 220 Asp Ala Gly Unk Val Gly Ile Lys 125 Asp Met Pro Leou Ser 205 Asn Leu Ile Ser Gly Met Glu Val Gly Cys Asp Asn Leu Glu Asn 110 Ile Asn Val Gly Met Glu Asn Asn 175 Ala Ser 190 Ile Leu His Thr Lys Val Leu Leu Lys Ala Tyr Arg Thr Phe 160 Pro Gly Asn Leu INFORMATION FOR SEQ ID NO:877: SEQUENCE CHARACTERISTICS: LENGTH: 394 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein PCT/US 96 /U9 1 EA i'D.C099 6 (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...394 (xi) -EQUENCE DESCRIPTION: SEQ ID NO:877 Leu Met Trp Lou Lys Thr Leu Thr Lou Gin Thr 1 Ala Ile Ala Thr Pro Asn G1n Thr Asp 145 Ser Asn Ser Glu Tyr 225 Trp Asp Lau Val Asn 305 Val Val Ile Asp Arg 385 Leu Gin Asn Ser Pro Ala Asp Asn 130 Ala Asp Asp Ser Ser 210 Gly Gly Phe Arg Thr 290 Pro Lou Giu Lys Val 370 Phe Gin Ser Asp Ile Ile Leu Leu 115 Ile Lou Thr Pro Phe 195 Ala Asn Gin His Ser 275 Asp Lys Ala Thr Ile 355 Lys Asn Giu Ala Leu Gly Asp Ile 100 Phe Lys Glu Leu Lys 180 Lys Thr Thr Ile Lou 260 Ser Arg Val Asn Lou 340 Pro Asn 5 Phe Asn Giu Gly Ser Ser Lou Lou His Arg 165 Giu Glu Lys Ser Giu 245 110 Gly Ser Lou Lys 325 Lys Asn Ser Ser Asp Arg Giu 70 Asn Sen Gly Leu Se r
ISO
Glu Phe Lys Val Gin 230 Ile Ser Lys Lou Giu 310 Asn Ile Leu Thr Lys Val Lou 55 Phe Gly Asp Thr Asn 135 Ser Lou Phe Phe Ser 215 Asn Lys Sor Arg Ser 295 Ile Thr Asn Pro Ile 375 Thr His 40 Lys Leu Lys Asn Asp 120 Gin Lou Ile Tyr Ala 200 Asp Lys Asn Asp Val 280 Gln Pro Lys Ala Ile 360 Lys Met 25 Ser G1u Phe Tyr Leu 105 Lys Asn Pro Gly Lau 185 Lou Lou Val Lou Gly 265 Thr Val Ser Lau Ser 345 Asn Asp 10 Giu Giu His Gly His 90 Val Asp Lys Giu Asp 170 Gin Asp Lou Val Thr 250 Asp Glu Lys Val Ser 330 Arg Lou Leu Ala Thr Met Gly 75 Gly Pro Lys Leu Glu 155 Asn Gly Lys Asp Asp 235 Pro Phe Tyr Ala Phe 315 Glu Lou Asp Lys Lou Phe Ser Ile Ser Asn Tyr His Unk 140 Val Asp Ile Ala Lys 220 Val Gly Asp Val Val 300 Val Ii0 Gly Ile Asp 380 Asn Lys Arg Asn Lys Gly Asn Lys 125 Pro Phe Lys Arg Tyr 205 Ile Ser Ser Asp Lys 285 Pro Thr Ph* Asp Pro 365 Ala Thr Thr Ala Val Val Glu Ile 110 Lou Asp Ile Asn Pro 190 Gin Gly Lou Giu Leu 270 Ser Asn Lys Gly Glu 350 Ile Ile Asp Lys Ala Ala Asp Asp Ser Ile Val Lys Pro 175 Asp Asn His Asn Asn 255 Asp Ala Met Asp Asp 335 Ser Lou Lys Lys Lou Ile Asn Arg Lou Gly Thr Met Pro 160 Thr Gly Gin Ala Asn 240 Lou Ala Phe Tyr Asn 320 Lys Ala Leu 01u Asn Glu Gly 390 Gly Cys Gly Asn INFORMATICN FOR SEQ ID NO:877: HCT/US 96/09122 SEQUENCE CHARACTERISTICS: LENGTH: 394 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION .394 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:877 Lou Met Trp Leu Lys Thr Leu Thr Leu Gln Thr 1.
Ala Ile Ala Thr Pro Asn Gln Thr Asp 145 Ser Asn Ser Giu Tyr 225 Trp Asp Leu Val Asn 305 Val Val >(le Leu Gin Asn Ser Pro Ala Asp Asn 130 Ala Asp Asp Ser Ser 210 Gly Gly Phe Arg Thr 290 Pro Lou Clu Lys Gin Ser Asp Ile Ile Leu Leu 115 Ile Lau Thr Pro Phe 195 Ala Asn Gin His Ser 275 Asp Lys Ala Thr Ile Giu Ala Leu Gly Asp Ile 100 Phe Lys Glu Lou Lys 180 Lys Thr Thr Il Lou 260 Ser Arg Val Asn Lau 340 Pro 5 Phe Asn Glu Gly Ser Ser Leu Leu His Arg 165 Glu Glu Lys Ser Glu 245 1le Gly Ser Leu Lys 325 Lys Asn Ser Asp Arg Giu 70 Asn Ser Gly Leu Sen
ISO
Glu Phe Lys Val Gin 230 Ile Ser Lys Lau Glu 310 Asn Ile Lou Lys Val Leu 55 Phe Gly Asp Thn Asn 135 Ser Lau Ph* Phe Ser 215 Asn Lys Ser Arg Ser 295 Ile Thr Asn Pro Thr Met C 25 His Ser 40 Lys Giu Lou Phe Lys Tyr Asn Lou los Asp Lys 120 Gin Asn Lou Pro Ile Gly Tyr Leu 185 Ala Lou 200 Asp Lou Lys Val Asn Lou Asp Gly 265 Val Thr 280 Gin Val Pro Ser Lys Lou Ala Ser 345 Ile Asn 360 Lys Asp 10 Gu iu is ;ly His 90 Val Asp Lys G1u Asp 170 Gin Asp Lou Val Thr 250 Asp Glu Lys Val Ser 330 Arg Leu Leu Ala Thr 4et Gly Gly Pro Lys Lou Glu 155 Asn Gly Lys Asp Asp 235 Pro Phe Tyr Ala Phe 315 G1 u Lou Asp Lys Leu P Phe L Ser P 4 Ile Ser I Asn C Tyr His I Unk 140 Val Asp Ile Ala Lys 220 Val Gly Asp Val Val 300 Val Ile Gly Ile Asp sn ys rg Lys Giy As n Lys 125 ?ro ?he .ys Arg Tyr 205 Ile Ser Ser Asp Lys 285 Pro Thr Phe Asp Prc 365 Ala Thr Thr Ala Val Val Giu Ile 110 Lou Asp Ile Asn Pro 190 Gin Gly Lou Glu Leu 270 Ser Asri Lys Gly Gl 350 Ili Asp I Lys r Ala I Ala I Asp Asp Ser C Ile Val Lys Pro 175 Asp Asn His Asn Asn 255 Asp Ala Met Asp Asp 335 Sen Lou e Lys Lys Leu .le Asn Arg Leu ly Thr 4et Pro 160 rhr Gly Gin Ala Asn 240 Lou Ala Ph* Tyr Asn 320 Lys Ala Lou Glu 355 Val Lys Asn Ser Thr Ile POT/US 96/09! 2 733 PE/U 0 370 375 380 Arg Phe Asn-Asn Glu Gly Gly Cys Gly Asn 385 390 INFORMATION FOR SEQ ID NO:878: SEQUENCE CHARACTERISTICS: LENGTH: 102 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION 1...102 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:878 Leu Lys Ala Leu Asn Asp Cys Met Val Phe Phe His Lys Lys Ile Ile 1 5 10 Leu Asn Phe Ile Tyr Ser Leu Met Val Ala Phe Leu Phe His Leu Ser 25 Tyr Gly Val Leu Leu Lys Ala Asp Gly Met Ala Lys Lys Gin Thr Leu 40 Leu Val Gly Glu Arg Leu Val Trp Asp Lys Leu Thr Leu Leu Gly Phe 55 Leu Glu Lys Asn His Ile Pro Gln Lys Leu Tyr Tyr Asn Leu Ser Ser 70 75 Gin Asp Lys Glu Leu Ser Ala Glu Ile Gin Ser Asn Val Thr Tyr Tyr 90 Unk Phe Lys Arg Cys Lys 100 INFORMATION FOR SEQ ID NO:878: SEQUENCE CHARACTERISTICS: LENGTH: 102 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...102 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:878 Leu Lys Ala Leu Asn Asp Cys Met Val Phe Phe His Lys Lys Ile Ile 1 5 10 u Asn Phe Ile Tyr Ser Leu Met Val Ala Phe Leu Phe His Leu Ser 25 '^AW N, n ;\i1 n q P, f
CIT/
I P~NS 9~/~91 2 I Tyr Leu Leu Gin Unk Gly Val Glu Asp Phe Val Leu Gly Glu Lys Asn Lys Glu Lys Arg 100 734 Lys Ala Asp Gly Met Ala Lys Lys Gln 40 Leu Val Trp Asp Lys Leu Thr Leu Leu 55 Ile Pro Gin Lys Leu Tyr Tyr Asn Leu 70 75 Ser Ala Glu Ile Gin Ser Asn Val Thr Lys Thr Leu Gly Phe Ser Ser Tyr Tyr INFORMATION FOR SEQ ID NO:879: SEQUENCE CHARACTERISTICS: LENGTH: 265 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION 1...265 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:879 Met Lys Phe Leu Lys Phe Phe Ala Set Ser Val Thr Leu Asp G1u Lys 1 Phe Ser Gly Lys Va 1 Gly Phe Ile Pro 145 Sen Arg Leu Asn Ser 225 As Leu Asp Phe Tyr Ala Leu Ile Ala 130 Gly Val Ser Ser Asn 210 Asn Ser Met Leu Val Ser Glu Ile Lys 115 Leou Val Arg Leu Leu 195 Leu Val Met Phe Phe Val Leu Ile Asp 100 Ser Leou Ile As Phe 180 Phe Tyr Val Ala 5 Leu Ser Tyr Glu Phe Thr Tyr Ile Ala Ile 165 Ser Asp Leu Leu Ile i 245 Leu Phe Tyr Trp 70 Thr Leu Lys Ala Ser 150 Lys Leu Arg Pro Val 230 Ala Cys Sen Gly 55 Leou Leu Leu Asn Ile 135 Val His Ser Gin Ser 215 Ile Phe Asn Lys 40 Cys Phe Phe Ala Tyr 120 Lys Leu Leu Leu Gin 200 Asp Ala Leu Ala 25 Gly Ala Ile Met Thr 105 Leu Ile Gly Thr Ala 185 Ala Tyr Lys Ile Giu 10 Leu Phe Leu Gly Phe 90 Asn Leu Ile Leou Lys 170 Arg Ile Leu Ala Ile 250 Ser Leu Ile Ser 75 Lys Ser Tyr Arg Ser 155 Asn Gly Lys Ser Arg 235 Pro Asn Gly Pro Gly Met Ser Tyr Phe 140 Ile Asp Phe Phe Ser 220 Ala Tyr Ala Ala Lys Ile Pro Glu Ala 125 Arg Leou Ala Tyr Tyr 205 Thr G1u Thr Tyr Phe Lys Ile Phe Thr 110 Leu Ala Thr Ile Ser 190 Se Gly Ile Ser Lys Leu Arg Phe Ser Met Ile Leu Ile Leou 175 Ala Phe Asp Ser Glu 255 Asn Ile Leu Ser sor Lys Ala Leou Val Gly 160 Lys Tyr Leu :le Cys 240 Leu La Asn Glu Arg Glu Arg Glu Arg F- i/US 96/ 0912 !PEiUS i Ci99& INFORMATION FOR SEQ ID NO:880: SEQUENCE CHARACTERISTICS: LENGTH: 363 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_£feature LOCATION 1...363 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:880 Met Lys Phe Phe Leu Leu Lys Lys Phe Ser Unk Phe 1 Thr Thr Tyr Leu Leu Ala Met Val Leu 145 Asp Gin Asn Pro Leu 225 Ile Ser Lys Lys Ala 305 Lys His Phe Ile Ala Gin Lys Ile lle 130 Gly Phe His Ala Lys 210 Leu Leu Met Lys Glu 290 Ala Ile Phe Ser Gly Leu Ala Asp Pro 115 Glu Ala Lys Lys Gin 195 Thr Leu Lys Pro Lys 275 Lys Glu Lys Asn Lys Leu Asp Asn Leu 100 Lys Ala Leu Gly Glu 180 Lys Leu Thr Asp Leu 260 Gin Ile Glu Arg 5 Leu Glu Ser Phe Val Ala Lys Phe Pro Leu 165 Leu Glu Gin Tyr Phe 245 Asn Lys Ala Ser Pro 325 Lys Lys Lys Cys 70 Ile Tyr Ala Arg Pro 150 Leu Glu Arg Leu Gin 230 Glu Ala Ser Phe Val 310 Met Arg His Lys 55 Leu Asp Lys Asn Phe 135 Asn Asp His Leu Glu 215 His Asp Phe Gin Lys 295 Leu Asn Leu Ala 40 Pro Asn Asn Ser Leu 120 Asn Ile Ile Lys Lys 200 Ala Leu Lys Ile Phe 280 Glu Glu Gly Asn 25 Phe Pro Lys Asp Glu 105 Met Asp Tyr Leu Lys 185 Glu Lys Ile Glu Asn 265 Leu Asn Met Tyr 10 Ala Val Glu Phe Arg 90 Thr Iei Arg Glu Glu 170 Asn Lys Glu Asn Cys 250 Lys Tyr Gin Phe Glu 330 Ser Val Ser Thr 75 Ile Phe Leu Val His 155 Lys Gin Leu Leou Arg 235 Met Lys Leu Ile Met 315 Val Ser Asp Val Lys Leu Ile Asp Ala 140 Gin Asp Ile Glu Gin 220 Arg Ile Phe Glu Asn 300 Pro Leu Leu Phe Leu Leu Asn Glu Leu Gin 125 Lys Glu Phe Ile Lys 205 Thr Glu Glu Thr Glu 285 Tyr Val Tyr Asn Leu Ser Lys Ala Ile Arg 110 Glu Asn Glu Leu Lys 190 Leu Gin Asn Ile Leu 270 Glu Val Lys Tyr Thr Leu Ala Asn Lys Lys Leu Lys Asp Asp Ser 175 Arg Glu Ala Arg Asp 255 Ser Asn Arg Asn Lys 335 Gin Glu Pro Thr Ile Gly Glu Cys Ile Leu 160 Tyr Leu Asp Ser Val 240 Lys Lys Leu Asp Ser 320 Asp A crla, i %it i6- PCT/US n9 1?2 I PENUS 1 736 Unk Lys Unk Gly Leu Gly Lys Thr Lys Lys Arg Ile Ser Ser Phe Tyr 340 345 350 Lys Thr Gin Unk Arg Met Ile Unk Gly Cys Unk 355 360 INFORMATION FOR SEQ ID NO:880: SEQUENCE CHARACTERISTICS: LENGTH: 363 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION 1...363 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:880 Met Lys Phe Phe Leu Leu Lys Lys Phe Ser Unk Phe Leu Asn Thr Gin
I
Thr Thr Tyr Leu Leu Ala Met Val Leu 145 Asp Gin Asn Pro Leu 225 Ile Ser Lys Lys His Phe Ile Ala Gln Lys Ile Ile 130 Gly Phe His Ala Lys 210 Leu Leu Met Lys G0 lu Phe Ser Gly Leu Ala Asp Pro 115 Glu Ala Lys Lys Gin 195 Thr Leu Lys Pro Lys 275 Lys Asn Lys Leu Asp As Leu 100 Lys Ala Leu Gly Glu 180 Lys Leu Thr Asp Leu 260 Gin Ile 5 Leu Glu Ser Phe Val Ala Lys Phe Pro Leu 165 Leu Glu Gin Tyr Phe 245 Asn Lys Ala Lys Lys Lys Cys 70 Ile Tyr Ala Arg Pro 150 Leu Glu Arg Leu Gln 230 Glu Ala Ser Phe Arg His Lys 55 Leu Asp Lys Asn Phe 135 Asn Asp His Leu Glu 215 His Asp Phe Gin Lys 295 Leu Ala 40 Pro As n Asn Ser Leu 120 Asn Ile Ile Lys Lys 200 Ala Leu Lys Ile Phe 280 Glu Asn 25 Phe Pro Lys Asp Glu 105 Met Asp Tyr Leu Lys 185 Glu Lys Ile Glu As 265 Leu Asn Met 10 Ala Val Glu Phe Arg 90 Thr Ile Arg G1u Glu 170 Asn Lys Glu Asn Cys 250 Lys Tyr Gin Phe Ser Val Ser Thr 75 Ile Phe Leu Val His 155 Lys Gin Leou Leu Arg 235 Met Lys Leu Ile Met Ser Asp Val Lys Leu Ile Asp Ala 140 Gin Asp Ile Glu Gin 220 Arg Ile Phe Glu Ash 300 Pro Phe Leu Leu Asn Glu Leou Gin 125 Lys Glu Phe Ile Lys 205 Thr Glu Glu Thr Glu 285 Tyr Val Leu Ser Lys Ala Ile Arg 110 Glu Asn Glu Leou Lys 190 Leou Gin Asn Ile Leu 270 Glu Val Lys Leu Ala As Lys Lys Leou Lys Asp Asp Ser 175 Arg Glu Ala Arg Asp 255 Ser Asn Arg Asn Glu Pro Thr Ile Gly Glu Cys Ile Leu 160 Tyr Leou Asp Ser Val 240 Lys Lys Leu Asp Ser 290 Ala Ala Glu Glu Ser Val Leu Glu I /ljc, IPENUS DC1996 305 Lys Ile Lys Arg tnk Lys Unk Gly 340 Lys Thr Gin Unk 355 310 Pro Met Asn Gly Tyr Glu 325 330 Leu Gly Lys Thr Lys Lys 345 Arg Met Ile Unk Gly Cys 360 Val Leu Tyr Tyr Lys Asp 335 Arg Ile Ser Ser Phe Tyr 350 INFORMATION FOR SEQ ID NO:995: SEQUENCE CHARACTERISTICS: LENGTH; 822 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .822 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:995
GACCCACGTA
AGTAGAGGAG
TTATGTAT
AAGGGAGAGG
CCTATTAAAA
AGGGGTGTAC
GATATACCTA
AAAGATGAAA
GCTTATATCA
AAACGACAG
CTAGGGGATA
GCTGTGTCT
TCAGAGCCTT1
ATCCAAA
GTTTCTTrIIT
TACATOG
TTAGCACCCT
AGGCTrATA.A
ATGGTGAGTC
CTAAAGATA
GAGGGTATAA
AGAAAGCGGT
ACTI'AGGCAT
AATGTrAG
TTTATTATAG
ATTATAAAAT
ACCGGTATGG
CATGCGAT
AAGATTGGTA
ATACGCAAC
TOGTGACCAA
TAATAAGGAA
GCTITGCTAT
CAAGAA.AGCG
CAAT1T'G=G
GGAATATTTIT
CATGTATATG
AAAAGCOATO
CGGGAATGAT
GCGCCGAT
GTIAGGCGTG
TGACATTIGAT
GCTATGOCAT
AAATTAGCT
CACC LTGAGC
TATOACAG
ATI'CT= AG
GTTGAATATI'
GTGATGTATA
AGAATAGCTA
GAGGGCAGGG
CATAAGGGCA
CAATTGGGTA
GTGAGTTCTD
GAAAAAGATA.
AAAAATTGTA
TATGTII'GAT
TAAAGATITG
AAAAGGGAA
CGGCTTCL I
GGATCATGTA
TCCAAAAAGC
AAGAGGGTAA
CAGAGAAAGG
GAGT'rCCAAG
ATGTGGAAGC
TTGAGCCGGA
CTAGAGCTI!A
AAAAAAAGGC
AG
CTTAATrAAT
TTGGTAGGT
TATATTTAT
TATAAGAGC
TGAAAATGGT
TGTTCATAAC
GGGAGTTCCT
TTATACTAAC
TAACTATGCG
TATAT CTC
CAAAGATAAG
TGAAGGGTTG
TGAAGAATAC
INFORMATION FOR SEQ ID N0:996: SEQUENCE CHARACTERISTICS: LENGTH: 447 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori
T
M'E J 3:~iT POT/US 96/09122.
IPENUS 18 DEC 1996 738 (ix) FE.ATURE: NAME/KEY: misc~feature LOCATION .447 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:996
ACCATCAAAA
GCTACCCCTT
AACATCCTCA
GACATTTI
TATAG7I'TCA
CAAAATATCC
AGCAAAAMAG
CTCATCCTTT
ATACATCGTC ATCAACGACT TAGGCAAGGG AGCGATTAGC AACAACTCAC CCAAAAACAA CTGATGGCGT TTTATTGGAC CCGGTGAAGA TGTGTGCGAA.
TTCMAGC'I G CTI'GAATTTA CCTITITAAA CCATAAAATG GTGAAGATGA AAGCGTT 'rrAACAATGA
ATCAI'AAAA
GACTTCACCC
AAAGCGTIAG
ATCCAATCC
GGGGCTAGGC
GATITGAGCG
ATGACACCAT
TCAGCGGCCA
CCAGATACGC
TGATTrATTr
ATOGAACCCC
TCGCTWAGC
A3ATTG~AAGC TGCCGCTAT1C
TAACGCCCTA
TACGTGT03C
CAAAGCCCCC
CCTTTAGCG
GGGGGAATTr GAGCGI'CkG INFORMATION FOR SEQ ID NO:997: SEQUENCE CHARACTERISTICS: LENGTH: 804 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc.fieature LOCATION 1 804 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:997
AATCTAATT'
GAGCCGATGA
GGTTATGAAG
AAGCCGGTAT
GTGGCAGAAA
TITGAGCGAAG
A'TOGGCTCTT
GCCCCTCCCA
C'ITATTAATG
GGCTGTAQCT
ACI'CCACAC
GCGGAGCTTG
AATTTAGTGA
AACTIAATGG
ATCGGAGCTC ACAAAGGAGC TTGAATAC?1' GAAATCCAAT ACAAAGAGAC TI'TGAAAAAA TGTTAGAGCC AGATAGTAAC TCACGGAGCC TATTTTGrGCA TrI'rAGCGGA TACGACCGGC QCATGACOAA TATTGGGCAT GTC!AAGCACG CCTITGGGTA AGGGCTATTA TGCGATT TGTGCATGGG CAATCAAGCG GGAATTTA TAATCGTATG GGGCGGCGTG CGCITI'ACTA GTGAAAAGCT AGAGAGCCAA AGAATITTCAG GCTC
GCAGCCGCTI'
ATCAAGCTCA
CGCAGAGATC
GCCCAATACG
TGCCCTAATG
AAAAGACCCC
TTCAGAGCCT
GTGCCACCCA
GGGGCTGCCG
AGGGTTAGGG
GGTAGAGGG
GGGAGGATCC
AAAGACAAGA
GCGTGGTGCG
'I GATGAGAT CGAT GCA.AGC
CCGCTGTCAT
ACCCTGATGA
ACGCTATTGA
TTGGTGAAAT
GTAAAATGGA
GGGCAAGGAC
ATAATGCGGT
CTAAAGTGTA
CCACTAAAGA
TCTATCGCTA
'TrTGAATAAA
GATTGCAAGC
TTGGGTGGAT
TGAAATTGAT
CGTCGCTACT
TGAGTGTTTI
CGTTAAAALC
CGAACAAGAG
TGAAGTACCA
CGTTTrI'I'cT
TTTGGGCAGT
AGAATACATG
CATGAWTTIT
120 180 240 300 360 420 480 540 600 660 720 780 804 INFORMATION FOR SEQ ID NO:998: Ai) SEQUENCE CHARACTERISTICS: LENGTH: 1290 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular S (ii) MOLECULE TYPE: DNA (genomic) PCT.*. /0 22 1 P-ASJS 18 0E C1996 739 (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-.feature LOCATION 1290 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:998
AAAATOCCAT
GT'I GTATGA
CAGCAAATCA
AATCAAATCT
ACTTATACA
GCTAAAGAAA
GGCCGTTATG
GA'TI'CAATA
TATAAAGAAA
GTGGAAAAT
AAAACGCAAT
ATTGATTATA
ATGAATACG
AACGTTGAAG
AAI=IAGAA
ACTAAAAGCG
CTTTCCACAC
AAAATTAT
TCCTTATTAG
GAGATGTTT
GACAATCAAG
ATAAAAAACG
ACGCCTTAAG
TAAATI'IGCA
'rrAAGACAGA
=~CTIT
AGGACATCTr
GCTATGAGCC
CGATITTAGT
TCCAAGTCT
TGAAAAAGA
TGCTCCAAAA
TAGAA.AATCA
AAGAGCAAT
ATGATGATGG
TCAAACACCA
AACATGATGC
GTCTGATCCT
AAATCAAT
TCAITrGTCAA AGAGCGATTfl
TAAACACGCT
TCCGTTIACCA
AAAGCGAAAC
AAAAAGATTT
TGCCAAAAGC
GCCTTGCTCT
ATCCCAATAC
A.AACAAACTC
TAAGA~TGAA,
GATGAACACC
TGACAGCGAT
AAAAI'rCCCT
TACGACTATC
TACCGAGCT
AGGCATGCTC
CCTGATAGGT
AGAAAACAI'I
G1'ITI'I'AAA TrCTCAAATA
CA.ACCCCTCT
TGCCTTGCAA
AAGGCATGAT
AGATCCAT
CAATCAAAT'
AAAAAAAGAA
T'TCAAACCCC
TATCTGTI'r
TGGAGTCGCT
GATGATAACA
AACCCCGTAT
TAGCGAT
CrrrrAGCGT
GAAGAAAGCC
TTTATCATCG
AATACCCCTA
TCTTTAAGCG
GCAACTTTCA
CAACGCTT13A
TCTTACAAAC
AAI'CTACCT
GGGC'TITAG
TI'ACTCTI'GC
AACAGCGATG
TGGGTGAATT
TTTAAAAAGT
TATCAGGCI'
'ITITA1TrGTT
CTCCTTTGCC
TGAAAGACTT
ACCAAGATGA
TCATCGCT'C
TACTGCCTAA
ATTTGAACAC
CTGAAAAATr C'TrATTGAC
CTTATGTGCC
AGCGCTTGTA
TTAGCCCTAA
GGCAAATCAC
AAGCGACCAG
TAATI'TGAA
AGTATAAGCC
TCACCCAGCC
AAACGCTGAT
ATI'CCAGCGC
CTIITCAAGA
TAGGGTATTC
TrIATT
CCCAGCGCAC
GATGCTGCAA
GAGCCTTAAA
TCAAACTCCA
AAAGGTGGTG
CAGAAACAAC
AGAAGAAACC
TAAAGAGGGC
TACGGTGAAT
T~rTGGGGG
TTCGCCCGTG
GGAGTCTTTA
TTTCTA.AA.
CACCCCTACC
TCTTAAAATC
TAAAGACAGG
AGAATACGCT
GATAGGGCTA
GAGTITGGA.A
TITIAGCCG
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1140 1200 1260 1290 INFORMATION FOR SEQ ID NO:999: SEQUENCE CHARACTERISTICS: LENGTH: 1458 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/ (EY: misc-feature LOCATION .1458 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:999 TA?1' AGATA
TATGCGAGTG
TGTTTGTF
GGGGTAGCGG
GGGAT''TCC
ATTATTGAA
GGAAATTAAA
CCATTCTTTA
AATCTG'TrC
CTACAGCCAC
TACTTTTATT
AAGGKTGGT
TAATCAAAC
TAAAGTGGGG
CTITGTAACC
TTTAATGGGT
GCGGTGTTAA.
CC TTATGG 7I'rAACCAT
GCCACGATCA
T'rrTAAGAAA
ANTTCAAAA
CTTTGATTA
CCAAACTCAA
AGCTTCAAGT
GATAGACTAT
ATTACCCTTA
TAAGT AGT
'ITCCAAAGAA
GGA?1'CCAAT AM S H EET P C IPEAS 18 /0 912 740 C T C TC CCTA G3CGCTCc TT
TCAGAACTTTI
GACTCCCTCA
'TT ATTCTI'
TTTATGAGT'
T*rAAAATG-GT
TATGCCCCTA
CAACTCTATT
ATI'TACGGAG
GGGTTAAGGG
GATGTGTATI'
CGCTI'TACT
AACGCAAGGA
TATGGTGGG
GGGGGGGTGT
GCGAGCGAAA
GATGAAIT
AC COC C C TI
AGCATGAAAT
AAAACATrGA
ACGAI'CCAC
TITACCTCAT
TAGAATCTGA
ATGGCGATAA
CCTACACACA
'PIAGCTCTrT
TTGTAACTGA
TITCTAGCAA
CCCCCGG7TT
CTCAAACCAC
GGCGTAACTC
ACAACGAAT'
TTGGCTCGTA
TCI'CAGTAA
ATAGAGGGTr
GATCCATCAA
TAGAATACTA
TCAACAAAGC
TC I T7rI
AAAACACAGC
CAAA.ACGCTC
AGGGCGI'G
CGCTCACACC
ATTCCACCTA
GGGT717CAA
TGGGAGCGCG
ACATOOCAGA
GCATGTTCAA
TAAAATCCAT
TATTAATGTG
TAAGAT'GGC
TAACI'ITGGC
TGGTA6ACCCC
CGCTATI'ACC
TTI'ATGGGGT
CTTIGAACTTG
TGTGGTCAGC
cTTIAAGGCT TTrAAAAATAG
ATAGACCAAG
TGGGGI I
CGTAATTATG
AAATTAGGGC
CTGGATTATA
TTGGCIrTL'G
AAAGAAGT
GTCATGCCT'
ATrGATAGCA
ATITI'CCCTG
GAGTGCWCG
TvTTGGT'AT'
ATCCCTI'A
GCAGACGCCG
ATTTTAGGCA
GGCTATAAAT
ATGCACAACG
GACGCACAAG
GCGTIrGGGG
CCACGCATCA
TAGGCAACGC
TGCTGTATAA
GTI'ATCTCTC
AA6ATCAAT'C
GGCAATGGAT
ATGATGGCAT
TIT3CTIATT ACCCGAAATr
TI'TATGCTAA,
CATCGCTITI'
ACCAAAATTT1
ATI'ATAGAAA
TI'TCTGGGTA
GATACACT'A
GGGGI'CTTTI
GCTATAGATT
ATAGGAGTAA
GATITTAGGA
AATCTATGGC
TCC GGAAA
?I'CCTATCTOG
TAACATGCAT
TAAAATAGCG
ACGGGATTOG
CCATGCCGCG
TTCGCCTAAG
CAAAGGC LTA
AGATTTATAC
GATCCACCAA
TGGCAACGCT
TAACAGCGT'
TGTCITTTGGT
TGCCACTAGA
TGCTAGAGT'.
AGACTATCTC
CCTTATGGT'
360 420 480 540 600 660 720 780 840 900 960 1020 1080 1140 1200 1260 1320 1380 1440 1458 INFORMATION FOR SEQ ID NO:1000: SEQUENCE CHARACTERISTICS: LENGTH: 762 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc...feature LOCATION I1.. .762 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1000
GTI'TACGCG
GAAAACGCT
CGTI'CATGCA
TTTGTGCCGA
AGCATTGTGT
AGCTCTCTIG
AGAATCTACG
GCGTTTGTT
CCTGCTZ'TAG
GATCAATCTA
GTTAAAAGCA
AATCAAACCG
GATGAATTGG
GGTITGGCTAT
TTrAAAAT
AAGAAATCGC
?I'CTAACCTI!
ATGCGC'T'Tr
TCTTAAAAGC
CCCCTTTATI'
'TTTAATCGC
ATGAGGGCGA
AAGATCTCAT
TTGTCGCGCG
ATAC ~TI'AT
TTAGAAAAAA
CGCTATAGGC
GAGCGCTAAC
CGTTTCAGTOG
ACAGGGGT'A
AGGCACTTTA
CACGCCCCAT
GGATrW1*r AAGCCTr T
TGTGGTITT
GTTAAACATT
CACAGGGAGC
TTCTTTCATC
TCATGGATTC
ATGCTCAT
ACTAAAACCA
GTGAGCGGGG
GAGGGCAAGA
GI'CTATCCA
AGCGAAACCT
GTGCATAACC
?I'ATTCCCTTI
AGCGTWGAAA
GAAAGCGCGA
GATGAA7I'GG
CCTAAAAAAG
TITAAAAGAC
ACTCATCTGT
CTAAACTCCA
TGGTGATCAT
TGTI'IAGQCC
TCACTATCAT
TITTTAACGAG
CTAAAAAAGT
?rTTGGGG=AA
CCACCCCCTC
TTAAAAAGCA
GGCTGGATTT
AATGGAGCGT
GGTAGTGGTG
TGCAATCTAT
TATTGTG'TrT
ITTTAGCGCAA
TCCTGTAG'T
GTTTTAAAC
GATITTTAGGA
GAATTTCATG
TATTTCCI'TA
TGTCAAAGAA
AGGGGGTI'TG
TAAAACCAAA
120 180 240 300 360 420 480 540 600 660 720 762 INFORMATION FOR SEQ ID NO:100l: SEQUENCE CHARACTERISTICS: LENGTH: 471 base pairs -7 TYPE: nucleic acid Aat I V-0 t I 4i e r PCIus 9 6 /09 122 IPEANiiS 18 DEC 1996 741.
STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTH~ETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION .471.
(xi) SEQUENCE DESCRIPTION: SEQ ID NO:lO01 TGT GTC
ATOCGTATAG
GCGGAITTTAG
CATAAAAACC
AAAAATAGCG
AAAAGCGATA
ATGCCGATTG
AGCAAAAAAA
TAACATGCTA
TTAGAAATI
AAACCGGAAC
ATGGCTCAGA
GATTAGAAG
AAAGT=IIA
TGAA=~CAA
CCCAATACAT
TGGTAGTGTG
ATTTCTTGTA
CAAAA.ACCAC
AACCCAGACT
CGTOGGATI'A
TAAACAACTC
TAAAGCCCTA
GGACGGCGGG
ATAAAGAAAG
TCGTTGTGG
AAAAAGAGCG
AAAAACGATA
GAAAAAAGCC
GCTAAAAACA
TCITIrTGGGC 7ITGATGATGC
GCTATATAAG
CGTATAGTAG
GTAAAAAATT
AAAAGCTTTA
CTAACCTTAA
ATATCGCTIGA
ACATCCGTTT
AGGAGATCTT
TGCGTTCGCA
TrACAAACTC
TIGATTTCACT
AAGCCATAAA
AGGGGTGAGC
AAGGACTAAA
T
INFORMATION FOR SEQ ID NO:1002: SEQUENCE CHARACTERISTICS: LENGTH: 675 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-.feature LOCATION 1 .675 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1002
CCCAAAATTG
GCCTI'AGTGC
GTI'ITGAACG
AGCCATAAGT
CAAGATTTGA
AAGGAAGTGT
GCCTITAGCG
ATGATGATTA
CTT=GCCTG
ATTI'CIATT
AAGATCATGA
TGGAGCGAAG
CACCGCTGC
GAGCAACTCT
CGAGTTTCT
TCAACGATGA
GCGATATTGT
TCGCGCAAAG
ATCCTAAAGA
GGGCTAAGGG
GCACAGCCAT
TGGAPAAAGC
TI=CTTTGC
TGCAT
CAT13GCATA.
TTTGGGTOG
AGCCCACI'C
AAGGCCCTAT
GGCGTATCTC
TTGTCAAAGG
'rITAGCCAAT
CGAACATGGC
GCCTAGAGTG
GGGCGATAGG
GGTGCTGTCG
AATCCCAAAA
GGCCACCGGA
ATCAAAGACC
CCTATGCCGG
ACTTCTATTT
TGCCATAOCC
TATTrAGGCT
=~AATGITT
GGATTGAATG
AAAAAGCATG
TTCI'GGCTT
CATTCCAGCC
ATTTAAGCCA
CGGT1GAAAAC
CGFTTCTCA
TGCCTAAAAA
TGGATTATGC
CTCATGCGCC
TCATCAACGA
AAAAAGCTCA
AAAGGAATAC
ACGACTIGGAA
CCTATGGATA
TGTGGCGGGG
GGCGAAATTG
AT'ITAGCGAT
?I'TGAGCGAT
TAAAGATAAG
TGATTTCC
TCCGCAAAAG
AAAACAAGTC
TAGGGAI'
AAGAAAAGIT
120 180 240 300 360 420 480 540 600 660 675 'A14r.Mrrn P4,7 IPEA1J 9 i 2.
DE dDS i6 INFORMATION FOR SEQ ID NO:l003: SEQUENCE CHARACTERISTICS: LENGTH: 1143 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: No (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION I1.. .1143 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1003 ACTrGGCGGT
ATGAAAATT
TTTACCGGTC
GGCCTTTGTG
AGTGAATTCA
AACACCGCTA
ATCCAATACC
CATATGACAA
CCATCCCTTITI
CATTCTAAT
GAAITrATCTA
AAAGAATTGA
AGAAAGTCTG
AGGCTTTrTAA
ATAGACAATC
AAAATGCAAG
~TI'GCCACCA
GAAACGGGAG
TTTATCAGAC
GC
ATCAACTAGG
ACAAAAATTT
AAAACGATC
ATCCTACTGC
GAAAAATCAA
ATCCCATTAG
CCACACAAAC
ACCTTATAAA
CCCCCATGAC
TAGATAAAAT
TTGTTAATTC
TTGAAATCCT
TCTATATCCA
ATTTGTTI'GG
GTGTCAAGTA
AG TTIAAA
CGCACAATAA
TTTTTAAAGA
ACAGCTATTC
CTCATTAAAA
TGAGCACCTT
GGGTAAAACC
CAATCAAGTC
ACTCGATGCC
TATCCGCACT
CAGTTACAGC
CACAACAATA
AATGACTI'AT
CGCTCAAACC
TCTTAAAGCA
ACAATGTTTC
AATCAAAGAT
TCTTTTTAT
AGCTCTGTI'I
GGAATTrA
CATAGCCT
TATGCTAGAA
GGCAAAATCC
AAAATGGAAA
AATCTTTTAG
AGTCTTCCTC
GACAACCTAA
GAATTTGAAC
AAAGACATCA
ACGAAGCCAC
GAATTTGAAA
TATAAAGAAA
AACCCTAATA
GAAAACACAC
ATCAAAT'CT
GATGAAATAG
AAGTTAGCTC
TI'AAACGCCA
tTTAGCTTG
AAAGCGCTT
AAATGATTAA
AT11'AAACT
AAGCTCTTTA
CTGAACATGC
AAACCTTTT
ATOCTACTAT
ATZ GAATAG
AGCTCCAATI'
GGCAAAACCT
TACAATTAGC
TITTAAATGC
CGCTAGAAGA
TTATTATGGT
AAAGCGGTTT
AAAAATTACA
TCAACACGAT
AAAAAGAAAG
ATAGGGGTAT
AAGCGTAGAG
CATCAACTT
TACCA.ACACA
CGTGAATATT
TIATCAAGGA
CCCTCrI'ACT
CGATGATGCT
TCCTACAAT
AGGTTAATC
TATI'CCTATA
AAGCAAAGAA
TAATACAATA
AAGTCCCAAA
GAGCAT1CT
OCACCATACA
GA77CAAAIT
ATCCGATAAT
CGCTTCTGGC
0GAGGTT'AGA 120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1140 1143 INFORMATION FOR SEQ ID NO:1004: SEQUENCE CHARACTERISTICS: LENGTH: 852 base pairs TYPE: nucleic acid STRANVEDNESS: double TOPOLOGY: circular ADi MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (Ax) FEATURE: NAME/KEY: misc-feature LOCATION .852 PrT!' "7 O9 12 IPEMAJS 1 8DC196 743 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1004 ACCCATTCIT TAT~ccTT-G GAr1'AAACC ATQGGTTATTA AGTAAAAAGG CCG TGTGGA ATCAGTAAAA GCCTCAACCC CAAAAAACCG GCAI'TGA'T1 TCAAGCGTG AAGTGTTAAA TGCAGCTrI' TAAOGGCTI'A TTAGTGCAAC GAGAAACCC TTTCA.AGTCA TTAGCCCCAA CGTTATGGCA CAGGCAAAAA ACGGCTA GGG TIG CTAAAAA GGGTrCGCT G AAGATGAAAG GGCAAGGAAG AGTATTACGC ATI'TAGTGC GTTACAATTA AACCGCTTAA AA
TGGTAGTATC
CCAATI'AGGA
AGACGTITTTG
AGAGGNTTC
ATCCTTAGAA
GGGGAGCGTC
TGCGGTGTTT
CCCTAATGGC
AAGCGCTAGA
CGCTCAATTT
CGGAAGCTAT
GCAGGTTIT1
TAGCAAGAT'
CCTATCGCCC
AAAA'=TT
AAATACACCA
ATCCAATCTA
TATAACGGGC
GCCACAGGAA
TCI'ATGGCT
TCTAATGAAG
GATATACA
AAAATGAAAG
GAAGGGCTAT
AGCGCGGAGT
ACTATCGGCG
GCAGCCCCCA
TCTATTGCCA
TAATCCTTAA
ITTAAAGACGA
GCAATGTGGG
TTAGOCTA
AGATCCCTC
ATGGGTI'GAA
GCAAATTGAC
TCCCTAGCCC
AAACCrI'AAT
ACATAGGGGG
CCTATAACAG
TGGTI'ATCT
TI'TAA6AGA
TTCAAAACGC
AGAGGGCATI'
CTTTATCCCC
CATGATAA.AA
TGGAITI'TCT
ITI'GTCCGCT
TGCGACITI'
TACCCCCTAT
CAAACCCACC
TAAGGTGGTG
CAAAACAGGC
CTCT ITTTT
AGGCTCGCAT
A.ATCACCGAA
TIVTGGAAA
120 180 240 300 360 420 480 540 600 660 720 780 840 852 INFORMATION FOR SEQ ID NO:1005: SEQUENCE CHARACTERISTICS: LENGTH: 417 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .417 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:100S
GATAAAAAAA
CCATTAGGCC
ATCTCTCT'A
TCAATCCI'A
TI'CTATGvGCT CTTrACAACC
ATCACTTTAG
TACTTIAAT TATTCAAGGA ATATTTGGCT GAGCGCTIA TTGTCITTAA. ACTTAAAGGG TrGCGTTATrr TGTGTATAAA TCrATCG CTT1TGGCCG TTTCAGTGAA GTCCGGGTAT ATCACCGCAT TI'TAGTGATT
AAA'TIATGG
GTCGCACT
TATAGCGCTIG
ATGCCTGTTC
ATCGCATGOA
TTTAAATCT
TIr.AT7=GT
AATTTCATCA
CGCCTATTGC
GGTTrAAG
AAATGGTGAG
TrTTATCGC
TAAAAGAAAG
ITYIGTrrGIGC
AG'TITATGAC
GCTCrTTr
CTTAGCGCTT
CGCGAGTI'I'
TGCGATTTI'
CGTI'CAGTCC
TCATT
INFORMATION FOR SEQ ID NO:1006: SEQUENCE CHARACTERISTICS: LENGTH: 291 base pair3 TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO ANTI-SENSE: NO ~g*p
K~
744 (vi) ORISINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION I1.. .291 (xi) SEQUENZCE DESCRIPTION: SEQ ID NO:1006
CCTAAACCTA
AACAAGCT
TATCGCAT
CTCGCTCCAA
GGCACCGGCT
AAGGGGTTrG
TTI'CATACCC
ACCCGCTCAA
TTTTAACGC
CTAAAATTAA
CCCTAAAAAT
TAAACCCAAA
ACCCCACGAA
TATACACAGC
CCCTATA'-TC
CTAATGAGTA
ATAAAAGCGA
ATGGCCTTAT
ACTAACGCGC
ATGCCCATCA
AAAGAGCGAT
CAAACACAAG
TAGCGCTCGC
TCAACGCTAT
AAATACAAAA
CCGTTCCCT
CCACACCGTT
TACCTCACTG
CAAACCTGAT
A
INFORMATION FOR SEQ ID NO:1007: SEQUENCE CHARACTERISTICS: LENGTH: 1596 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular Aii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO Nvi ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-.feattire LOCATION .1596 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1007
AGAAACGATT
TTrGTI-ITGC
TTGGTGGATA
AAAATACA
AAAAACAAAA
TTAGAGTCCC
GAGCGCCCCA
ATTCTCA
TTAGGAGAAG
LTGGATAAAA
TIGCAAGGGG
GAAGCTATAA
?TTTAGCGG
TACAI'rGAAA
AGCGTGATCG
GITTAGGCT
CTCGGGTGGT
GCTAAGGGGA
A TITAGAAG
TTGTGC!CTA
AAAACGGTr
TCTAAAATTG
S.AAACAGCTCA
TTAAAGGTGT
AAGCAGAAGA
AAAAACTCGC
ACCAAATI"TA
AAAGCAAGGA
AGCAAAAAAT
ATATCCCCAA
TCAAGAGCAT
ITTTTAAAGCT
GCGCGMAATI'
CTCAAAACAT
GCATTGTCAA
CCCTITI'GAG
ATAATGAGCG
~TTAATCI'
TTGCGAGCGC
TTATCAITTZ
CGGATATIT
ACGTAACCTT
ACAATTACAT
GGGATGGCGT
CGCTCAATAT
ATAAAATGCG
TCCCTGAAAA
TGTCtTTTAAG
TACAAAAATG
TAAGAGCCAA
CAAAGACGAT
TACTG3AAAAA
TI'TATTAAAG
GTr'rGAAAGC
TATCCCTAAT
GCGTTTrAAAG
TTTAGATCAA
AAGCGATGAG
TCTAA.AAACC
ATCTCAAGIT
CGTGGTOT
CGTCTATACC
TC?TI'I'CT
GGGCTTAGCG
GATTGGG;GGG
TATTGGCGAT
TACCACTIAC
?rI'CACCACC
GGATI'TGC
CGCTACGGAA
CGACCGGTAT
TAACGGGATA
GAGCAAGATI'
GCAT1'AAGGG
GAATTATCAT
AACGTGTTGT
GAGAGCGTGA
ATrAGCACCT
TATGGGGTCA
ATCGCTAACC
CATGAAAATC
AAACACCAGC
ATTTATCAAA
ACGATCGGGA
A.AAAACCAGC
GCGTGGATTT
GTGAATAAAG
TATTTAGAAA
ATrGCGATGA
AGCGTGCATG
GTG'r GGATA
ACGAATAACA
ATGTITCGCTA
GTTACAT'ITQ
TrGTCTAAAG
TCTTTAAGGA
A.AAATCTCGG
GTGGCTG3AAA
TATTATTATT
CTATACAAAA
TGAAAATT
GGCAGGAATI'1
TAGAGCATAC
ATCCTTTTAA
CTATTGCGAT
TrAA)).ATAA TrAAATCA
CTCAAGCCAA
TTTTrCCA.AAA rrrAAA-
TAAAAAICAT
CCATTAACI'
ACG1'TACTTA
AGGATFITA
TGGCATAG
TTTCTATGIT
GQAGAGCGGG
A 1TACAGCCA
ATCTGATTTI
AATACACGGA
GTTTGAGCGT
TGTOGTATCA
*TTGTTAAGC
CrTrTGTI'rr
ACAAATGGCT
TGAAAACTAT
AAGGCGCT'A
CTTAAAGGCT
GGACTTGATA
CATTGATGGC
CCAGACTT1CT
GTGGCACGCT
ACGCTTAGAA
AGACACAT
GGTTTATGTG
Tr CCAGTAAA
CGTGAATGTG
CTI'GGTAACG
CATGAGCITC
GGTGCGTATC
GCACATI'ACG
CCGAATrATC
TTTTGGGATG
TAAAAAAGCG
TATTACCTAT
CAAGCCTCGA
AACCAATTCG
CTTTTGAAA
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1140 1200 1260 11320 1380 1440 1500 PCT11j's GAAGAAAATA. TCCATATCGC TIATACGACC AOCAAGCTGC TTAGT.; CTAGGCGATG GTrIGGAA TAAAAGGGAA CAAAAA INFORMATION FOR SEQ ID NO:1008: SEQUENCE CHARACTERISTICS: LENGTH: 1041 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-.feature LOCATION .1041 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1008
TGCTGATGCT
1560 1596
CCGAGTGAAA
TT~GGGGGAAC
GTGGCCGGGT
TOCOTGATAG
AXACGCCTTG
ATAAGCGATA
ATCCCTACOA
ACGCCTTATG
7TTAGC I 117
AAAATGGCGG
GATTGTTTAG
GATGAAAAAG
ATAGAAAACG
CGCATOOGCTA
ATAGAAAAT
AAATTACG
?TGCCTAAAG
AAGGTGTTAG
OAATGCAAGA
TGCCTGAAAT
TGCATTTGCC
AGTCCGGGGA
A.AATGCAArT
TGGTGGGGI'
CTTTACTCGC
GCAAGAACCT
T.AAAAACCCT
TTGTTITTGA
AAGAAGTAAT
AGCOAAACAT
AGACCAATTA
ATGATTTAGC
TATTAAAAA
AACGCTTTT
GTCTTCGAGC
AAAAATGGCA
AATC'ITAATC
AAAT1'GAA
CTATTTGTTA
AAAATACAAA
AAACCGCCAT
TGCGAGCAGT
TCA.AGT'GGAT
A.ATCGGATCG
TGAAAAAGG
TAAAAACTTG
CTITCAA.AGC
CAGGGCTrOOC
CGAGCGAT'I
CCTTTIC1YITA
ATTTGATCTG
TTTAGACAAA
GT1'TOAGATT
T
CCTTTAAAAG
CAAAAAGCGC
GAGCGCTA
AATTTTCATT
TCTTI'AATGA
GCGAGCGTGG
TCCACCAGC
GAATTTCAAG
GTAGAAAGAT
GTCAATATCA
TGAACTATG3 TGCATrGGCG
GQCATGCTCA
ATATTCAATT
AAACGAGA
GCCTCTCATA
AAAAAAGCTA
TCATCATTAG,
ACGCCITAGA
CATTAGAGCG
TAGCCCTI'GG
GGGGGATTGA
GGGGGAAAAC
CTAAAGCGGT
CGGGGGT'GC
TAGAAACAAA
AAGCTCAAGT
GGCATACCTT
AAGCGATCGC
CTI'rAAAAGA
ACCAAATCAC
ACCAAACCCT
TCCCTAAAGA
TAAAGTGTT
CGATAGCATC
AGTCAGAGTG
GATTTTAAAC
TGGGGGAGTG
TILTTAAT
AGGGATCAAC
?I'ATATGGAT
TGAAATCArr
GGATAAAA
CGTrGTTCAA
TGGCATGCTG
TATITGGCATG
ATACGAACGC
TGATATTCAA
AAAATI'CATT
AACGA'1'1TA 120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1041 INFORMATION FOR SEQ ID NO:1009: SEQUENCE CHARACTERISTICS: LENGTH: 588 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori
FEATURE:
ki" E "E *7 POT/US nq 1 9 IfPAAJS 18 DEC 1996 7"6 IA) NAME/KEY: misc..feature CB) LOCATION 588 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2.009
AAATCAAAGA
AACCTCACCG
TTGATCC'FIA
TCCAGTAAGG,
GAAAA'rTATr
GTTTATAAAA
AAATCII'T
-GCCCAAAC
AATGCATTCC
GAAGTCAAAG
GTATGAAATI'
CTCCCITI'AA
CTTTTGT
ATITrCTI'rA TTTrATGCTAA
TCCCAGAGAG
TAGCGTCT
GATTGGACAC
AACGATACGA
AAGAATTACT
AAGGAGAGGG
ACGCATCAAA
GTrGCTTTT TG3TGATCCAG
CAAGGGTCTT
CATGCCCATA
TETI1TCATT
TAAAATGAGT
TGCGCTAGGG
AGAAGTGATA
A.AAATCATGC
AACCGCTCGC
TTAATCTTAA
TCTCACCCTA
TATAAAACCA
GAAAAACCAG
TCTAGCATGC
TTAGAGAGCG
GTGCGI'I G
GATTATITAA
CGTTTTCTA
rI'GTI'I'GGC
GCGATGTC
AACAAACTCT
ACAAAGAAGC
AAAGTTTAAG
TTTITTGGGAT
CGCACAAAAA
AAGACATTGC
AAAAACCC
ATTTTAGAA
GTTAGGGTITr
TAGGCTCATA
AATTAAGAT
C7TTTTTAAGG
CAAGGTTTCT
C TITGGCGT
CGAATI'AGAA
AGGGGTGAAT
INFORMATION FOR SEQ ID NO:l01O: Ai) SEQUENCE CHARACTERISTICS: LENGTH: 537 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION I1.. .537 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:11O
ATGAAACCAT
ATAAAAACC
T71'CTATGGC AGCG7TI'TAG,
AAAGAAACCA
GAAAAGATCT
CCCTCCCAAA
CTTT~wT1CA ATrCTAAAG
TGCA'TITC
TrAT'-TTr
CTAGCATGCT
AATACGCGCA
GCGAATCT
TMAAAAAATG
AAACCCAAT!
CCTTAATCAA
ATAGCGACGG
ACACCTGGAC
AGGGOTI
GGATTAA
AAGGCATT
GTI'AAAGATT
?TTGACGcC
'TTTTATCATG
CAAGTATA
GTI'GTIGGTG
AGAGAGCAAT
TCCTATTIGG
AAAATCCTTTI
GAAACAGCCC
'TTAATGATG
TATAAAATCA
GCTAGAGCGA
CCGAGCGCTC
CAA'TTTGGCG
CAGGCG&T7T GTYT3GTITAA
TAGAAGAAAA
TAGCAAACTA
AAGAGTCCAG
AACCCTTGCT
GCGAATTGGA
AAAGCCAATT
TGAGTATTGA
GGGTTTTATC
TACCGAGTAT
TCGTAAAAAAA
CCGCAATCAA
GCGGATITTA
CTCTCAAAAC
AAAAACTTAT
GCCCTTAAAG
TCTCCAA
INFORMATION FOR SEQ ID NO:1Ol1: Ai) SEQUENCE CHARACTERISTICS: LENGTH: 1356 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO POT/US 9 6 /09 122 IPE4S 18 SDEC 1996 747 (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATUJRE: NAME/KEY: misc-feature LOCATION .1356 (xi) SEQUENCE DESCRIPTION: SEQ ID
TTTIAAAAGGT
GGGGTIGAAAC
AAAAAACATT1
ATGGTAGAAA
GGGCCTATGjC
ATTATGATAA
TATCGTTATA
GAATTACTGC
GATGTGATAG
CAAAAATTAA
GTTI'ITAGCG
ATTAATGAGC
CGTGCGGATA
TTAGGGAATA
AAAAACGCCC
GAATACCTGA
AGCGAATGCA
?1'TAGCGAI'
GTGTTAGAAA
AGCCTAGTGA
GCTCTIAA
GAkAACAAAT C. 3AATTAA KTI ATAAC
TCACCCCCAT
CTCAAACGAA
ACCTI'AGT
CTACCCCTGC
GCGCGAGCCA
AACTCAAAGA
ATCTAGCTA
GGCGCTATAT
GGATCGTGCT
AGC'T GGGGC
AATIGCGGGGC
TAGGCTT'GC
TCGTGCAT GG 'I CTTCTCA.
AATCCCAAGA
TGCGATTGAA
ACGCTAAAAC
GCAAGCTTGT
ATI'GAATAT
AAGAATTAGA
TACGAATCCT
AAGAA ETTTI'
GATGAAAAT
GITI'GTGATG
TAAAA'ITCTA
GAGCGCTCTC
GATCGCTI' T
CAACCCTI
AGAAGA6AGAA
TAAAGTGGGC
CGCGCATTIG
AGATACGGCT
TGATG~TIA
TTTACACCCT
TTTTGATGGC!
GGATAAGCTIT
AGCGGTTGTC
ITTTAGAATTG
TAAAGCCAAT
GGGCGATGGT
AAGCTCTATI'
CCAAAAAAAG
CCAACTAGAG
TTAGAAGCT
TGAAGGGCAG
TTI'GGGACTG
CGI'TAGGCA
ATCGGTAAAG
ACTI'CCATAG
TAACCGAAG
GAAGACAATIG
AGAGCGATTG
GAGAGCGTCG
AAGCACTCT
AATGGCGCGG
GTGATCAATG
AACCAATTGA
GATGCCGATA
TAGGGGTGT
GCTACGAGCA
AAGCATI'GCG
TTI'GGGGGCG
TTGGTGTGCG
GCGTTAAACC
C CC C C TTAG
ATCCGCCATT
AAAGACGAAA
TGTGC
ATCTGCGTCAG
T1GCTGCCGG
ACACCAGAAA
GCTATAATGT
ACATGCGCTG
GCATCAAGTT
AAGAAATCT
GTAGCGCTAA
TCCCCAAACA
CTTATAAGGT
ATIGAGCCTAA
GCCAGGAAGT
GGCTAGTGGT
TAGGGGTTTA
TGAGCAATITT
CGATTGGGGA
AGCAAAGCGG
CI TGCAAGT CCI'rTGAACT
AAAGCCTGAA
TGATCCGTTA
AACTITTTAGA
GGGTAAAGCA
ATTTAT'I'I
GAGCGGCTAT
GATCCAAATA
TOATGCGGGC
TCATGATGAA
AAGGATAGAC
TTTGAATTTA
GGCTCCGGTC
TGGGTGTAAC
GAAAAAATAC
GGCGGATAAT
TCAAAAATCT
AGCCCTTAAA
TAAGTIGTG
GCATATCATI!
GAGCGCGTTA
ATACCCCCAA
AGGTTATAGC
TAGCGGCACT
ATCCAAAATG
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1140 1200 1260 1320 1356 INFORMATION FOR SEQ ID NO:1012: SEQUENCE CHARACTERISTICS: LENGTH: 333 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-.feature LOCATION .333 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1012
AATCATCAGC
GCAAGCGAGT
TATAAACATT
TATCAACAGC
TGTAAGATT
CAAGCCAAGC
GAATACGAAG
TAAA.AGTGCG
CTGITTGCTI
GI'ATAGAGC
7TTATTCCCAT
TAAAAAGAGT
CCGCCAACAA
ATCTTGCAA
AAAGCCTTT
GTTTGCTCTA
AATTGATTT
CTCTAATGCC
TTTAGAAAGC
CAGAI'ITTG
TTTAGGI1711
ACGCTCTT
AAAATCGTT
TAT
CGTTTATCC
ATAAGGGTTT
GTITTCTCAA
CTI'GTAAGTT
?I'ATCCCTAT
CTTTZAGAAGA
AAAGCCCTAT
AATTCATGCT
?II'AACGCT
TCTAAAACAC
AMETHOED Sh2.A-. ?4
POUS
IPEWS
9/09 122? INFORMkTION FOR SEQ 10 NO: 1013: SEQUENCE CHARACTERISTICS: LENGTH: 600 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAI'E/KEY: misc-feature LOCATION I1.. .600 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1013
AAOCGCATGA
WITTGAACGCT
AACACCTA
ATTG'AAAAAC
ACCCCTAATG
ATGGGGGCGA
AGTAAII=
AGGGATI'7r
CTATCGCCA
ATACCAATCA
AAGAATCTTT
CTTTIAGGACG
ACATrGAATr
TGOTTATAG
TAAATTAGC
TGCTTAGCCC
TAAACGCTI'G
ACATTCAAGG
TAGGCACAAG
TTATACCGAT
TTACATAGAG
TAAGITT
TAACGAAAAT
CCCTAAAAAA
GT GGCGGTTl
TAGCC'TITA
CTT1ACAGCTI'
GTTAAAGCC
TrCTGCCTTA
CAGTGGTCI'
GGAATGACI'
GTGAAAAAAA
GAAACCAAT'
ACTCTAGCAG
ArTrTCACGC
CCTGAAAGCT
ATAGGCGCGC
TTATIGGCACA
ATTTCAGCCT
ATGGGCAT
GCACGGCGTG
TAGAAGTOAG
TAGACGAAAT
AAGAAAAAAA
T1'I'TGGT
TGCTTACGAT
TCATTGTCAT
GACAACCCAA
GTGGCAATTG
TICTAGCOGGG
CCTTAAAT
TTTTAAACTC
AGAATTTT
GTATCTI'CT
TAACCATCAT
GCAITGGGG
CATGAGCAGC
TATTTGGT
AGCGTGTGCG
120 180 240 300 360 420 480 540 600 INFORUMATION FOR SEQ I0 NO:1014: SEQUENCE CHARACTERISTICS: LENGTH: 723 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAZIE/KEY: misc-feature LOCATION .723 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1014
AAAGAGTCTC
AGTArIT'rI T TGTTGTTAG
ACCAACACCA
AGTCGCCC
GCGGTGA
,C7 GCACCAACA o
TAATGCCTAT
TAGGCATGAT
TGGTGGCGAG
CTACCAAGTT
CAAOCCTTAT
GCGCGTTGTT
CAAGC ATCC
TAACCCTCTC
GAGTArTT TC~rTT-rA
TGGTATTGAA
TACTTACTrT TGTGArrTrrT
CTATTCTC
TATC7TI'CC
TACGCTTCCA
GATGGGCTTIG
TTTGACTCTT
TATGTGGGGT
GGAGCGATAC
ATCOGTATCC
CCAATCTITT
GTTACCAATT
ATGGCCGTGT
TAGCTGATGT
ATAACTI'TGG
GATTAGCGCG
CCATTCCTGC
TACCGCTAGC
TGTCATGGCG
CGCAAGGCTT
GGTCGCT1*11
GCGTATAGGC
ATTCAATATC
GGCGGCGGTA
120 180 240 300 360 420 vu 1 /us 9 1PEUS 1 6 0 912 1U r-GGTGGTGC AAGTrAITTTT
CCTAAT=A
TCGTTAGTGT
TATCGCATCA
GCA
frLTrCGTGTr
TAGGCTITTAT
AAAAAGTCAA
'ITGTGCGCCC
TTCGGTGGAT
ATTAGATAAT
TGTCTTATTA
GTGGAATCTC
'rrrAGAGGCT CTTI TAATG
AAATACCAT
GGGGTG3crrA AAG3C7T1=CA
TGAGCGT-,T
GTAAAAATrA
TCTTAGAACG
TGGTGAGCAA
TCTTAGTGT
TT~ATGGGGTT'
CTTTAATA
CAATACCCAA
TATCCGCTAC
GATCTTTTA
GTATGATC
AAATAAAAGC
480 540 600 660 720 723 INFORMATION FOR SEQ ID NO:1015: SEQUENCE CHARACTERISTICS: LENGTH: 753 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1...753 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1O1S
TATITGCCCG
TTGAGCTTGA
TCTAAAGATC
TACGGGTTAG
TATCAAAGCT
ATAGATI'GTA
AAAATCArI'C
AAAAAAGAGT
CCTAACCAAT
TTTGAAGCGT
AAAGATATAG
TTAGAGATTG
CAAGCGAA)A
AAATAGACAG
CCTTTGCGTr AATrI'GArT
TT'GATTTAGA
ACCTCTCTAT
AAAAAGTCAA
TGCTTTTTAG
CAAGCGGG2'r
TCAACGCGAT
GTTI GCATGC
AAATCCAAAA
GGGATATTAA
CGCCCCCT G
CCTGTITTCT
AAGGCGT=r
GAAAGCGGAT
GGTITITAGAA
TATAAGAAGT
AGCCTTAAAA
CGCTrrCAAA
?ITCTACGAGT
CAAAACAAGC
GCCTTTAGAA
AAATCGTAAA
AGAAATTGCG
CCCTCTAGT'G
CTr'TIAGCG
AGTT'IWITGGGC
TTAAAAAACC
AAGTT=AC
GTGTTAAACA
CGC'TTrAG
CGATTAGCTA
CTTCAAMG
AC7TI'GAGA
GAATATITA
AATTTCT GT
ATI'
TTTTTAGTrC
TGGGTAAAAT
TATTGAAAAT
TCTTI'GAAAA
TGGAGCOCTT
CCAACGAGCG
ACAATCCTAA
ATATCAATAA
AATTACAAGA
GTTTGATAG
AAAGCGTC7CT
GGGGCGTGTA
A6ATCGTGGCT
CCCTAGCGGA
CATCGCOCAT
AGTGGGCGT
TCATAAITTA
AGACAT IGTr
GAACGCTCAA
AGACAGAAAC
GCATGCCCI'
CAA)AATAGAG
AGTCATGGAT
TCAAAGIT1' 120 180 240 300 360 420 480 540 600 660 720 753 INVORMhTION FOR SEQ ID NO:1016: SEQUENCE CHARACTERISTICS: LENGTH: 1782 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori
FEATURE:
NAME/KEY: misc-feature AMZ~iDEU SIKK- POUS 96/09 122 IPEVi'S .18 DEC 1996 750 UP3) LOCATION 1 1782 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1016
GTGGTCTI'TA
TTATACTTAG
CCTAACGCTA
AACCCTTTTG
ATGGTGCAAA.
GTGGCTAAGG
AACGCTCCCA
TCGCCCCITI'
CATGTTAAAT
I-rGCAGATCT
ATCCTGTTT
TACCAAAGAA
T11'GATCAAA
AGCGGGGCGT
GGGAAAGCTA
GGCATGCAAG
GAAGCCTTAT
TACAAGCGCA
CCTGAAGAAA
GAGCCTTATA
AATTI'AAAAT
TTGGTGGATA
GAAAGACTGG
CAAAGAGTGG
GTAGGAGTGA
TGAGCGCGA
GA'IITGATTO
GCOATOATA
TACAOGATCG
TCGCCGTATT
AAATTTAAG,
GCGAAGAACC
GAAAAGGCGG
CGCTTAAAG
GCTT'AGACGA
ATAACAGCTA
TTrTA3CGAG
ATAGGCAGTA
TCATTCAA
TI'CCAAAAA
CTAGTGGCCC
ACCCTAACTA
TCAAATI'rGA
ATGATTGGCG
TOGATAATAA
GGTTTTTCTT
TTTATGCGT
CCACTAGTT
AAGCCCTGCT
TCGTGCCTAG
ACGCCCAAAA
AGAATAACAA
CCCTAGCTT'
ATTTAAGCCA
TTGGCCAATC
AAGCCAAAGG
AAAGAATCAT
GGGTGTTGTT
CAGCGTATAAh
TATGGTGGAT
TTrATGG'ITA
CAAATATAAA
TGT'ITGAA
CACTAAAGCC
ACCTTTTGCA
TGTGATI' TT
CGATGTGAAG
TTACCAAGAT
AACCACTGAA
AGCGTTTCAA
TTATGTGATC
TTGGGCGAAA
GTATTACAAA
CCTTGAAAGC
AA.AAATCACT
CAACACGCGC
TGATITGAA
TTCAGTAAC
ACCCCT'AT
AACCGATGGG
GC'ZTrrAGAG
GCCTTTCAGT
TGCTAAAAAC
OTATGTCAAT
GTCTTCCCA
CACAAGGAAT
TCACGCTAAA
OCGGGGGTTT
TTACATI'GGC
AAAAAAAGAA
GGGGTTTT
GACAATI'TCA
AATCACGCTA
GAAGGCITrGG
GAATACCCCT
ACCCTAGATA
'TTAGCTTTG
GTTAALAAAGG
AATAAAGAAT
AAGGATTATT
GCTTCTT=TG
AATI'rGCCTA
GATGAAACCG
ACGGCTAAGG
AAATACCTCA
CGAGAAAT
TGGGCGAATA
TCTATCTATG
GAAAAGAGI'
CCTGATGTT
AGCGCGGGCT
TTCACTTTGC
'ITAAGGGTGT
CGGATCAAAA
GGTAATGAGC
TATGCGCGAA.
GATTATAAGG
TACGCGATAC
ATGCCTGAAA
AGGGGTCCTA
GTr-rCCTrAG
CGCATTTTGA
TAGGGACTTT
ATCTCA7A
TAATCGCTAA
AAAGAGCGAG
ATACGATAAT
CGGI'ATCTr
TGCCCCTCAT
77GAAA)AA
ATGTGGGCAA
GCAGAAAGGG
TCGCCITACA
TTGGGCTA;G
TAGCCCACAA
TCAAGGATAA
CGTCCCCTCC
TGGATGAAAG
TAGGCTATAA
TTTCCTACAA
TTAAACAG
TAGGCATITCA
GCTATGATI'r
AGCGCTITA
TCTCTAGTA.A
AGCAATrGGC CGCA'I 1?rA
TCAGCCCTAG
AA
GGCTACGCAT
ATACOCTAAC
TGATAGCCTT
TGACACTTrA
AGACGCCGAA
ATI'CAGCAAT
GAAATrAGGA
AGACAAGCAC
TTAGGGCAG
CCCTI'IACTC
GAAAATCACC
GCAATrCAAT
GGCTITTTA
GGGCTATGTOG
AATGCCAAGC
AAGGGTGCGT
TTTTTCGCA.A
TCTCCCAAGC
GGITTIAAA
TTGAGGGAA
AAACATGCGT
CCCGGCA'TT
AATGAAAATC
TGACATGAT1'
TTTGCTCT
AGCGGTAGAT
CGCCATI'CAA
TTTCCTAAT
CTATGGAT
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1140 1200 1260 1320 1380 1440 1500 1560 1620 1680 1740 1782 INFORMATION FOR SEQ 1D NO:1017: SEQUENCE CHARACTERISTICS: LENGTH: 603 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DN (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc..feature LOCATION .603 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1017
TCTGTGATTG
AAACTCGT
OCCATTAGCC
AGTTATTGC
VICGTTATTT
GTGTCTATAT
TAGAATCCAA
CCAAACATCA
AATCTCATTG
ATI'AAGCCA
TAGAAGATGA
CA'ITTCITIA
TOAAAAAITr
AGATTI'TGAA
GTATCATTCT
TTATCTI'A
TGTAACGCTA
AAAGAAAGTC
AAAGGCCGTT
AAATTACI'C
TATGTTGGCG
TGGAAAGAAT
GAGTCTCAT
AAAGGCGTIT
GCGTITCCA
AAGAGCTA
CTGG'TITGAC
GCGTCAAATI'
TCATGCAAGC
GGATACTGAA
AATCTTTGAC
TAACGCTCAA
TTTGCCTGAA
AGATCAACCG
CTTAGAAGAT
120 180 240 300 360 AM r, r. n Q ry ~PENUS i TGrrTrGAAA.A CCCCTTTTGA T ~rNTGAGA CTCTATGOGT ACAAAATI'CC ATGrir=c AAAGAATI= GTATTI'CCTC AATAACCf:TA TIAGAAAA ArVIAAAAAA ITrI'GATG TCTACCCATA AAGTCATCCA CCTATATTCT CAAAAAAATA
GCA
GTTIGTA
CCTTGATCA
TTTCTAGATTI
CAAAAAAGCT
TTACCACGAG
TrTrAAG TTTCTr
ATTACGCAAC
INFORM-ATION FOR SEQ ID NO:1018: SEQUENCE CHAR~ACTERISTICS: LENGTH: 1620 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION I1.. .1620 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1018
TTTAGTGAGC
-TGTGGATITTG
AATAATAATA
GCTCT7L1I'A
AAACAGGCT
GTGA.AAGAAA
-AAATCT.ATG
CCTTTCACGC
AATGATTTGA
CTAGACGCTT
CATTACGCCC
CATGGTTATG
CTAGAAAGGA
CAAAAAATCG
CTAAGCCGTA
III AGACA
ATGCCAAGC
GAGCCAAAGC
GCGGGCGGGA
CTCATTCCTA
GCCATATTA
AAGCAATA
CTAGGGACTG
AAGCAAA.ACA
GAAAACAAGG
TACACTTTTT
GGCGTGCCGC
GGGACTI=TA
GATTCTTOTC
ATACCCTACC
AAACCI71
TCACTITATIT
GCGATCTTAT
AGATrGTCAA
ATI'TAAA.ATT
TCCT?1AI
TGAATGAAAG
ACTCTAAAGA
GTGCTAATGG
CGCAAATI'G
GCT'rGCAAAA GC 171GCAAGC
TTACGCAAAA
CCTAAAT
AAACCATGCT
TGAAAATCAA
ATGACCCCCA
GCGCTCTI'r
ACGCTGATGA
ACCAAATCGT
AAGTGGAATI'
TAAAAGGGGT
CTT=AT
GCTI'IAGG
AGACGCTTCA
CAAACCCCTA
CGCAAAAGAA
AAATGAPLGTG
TGTT~GTCAAA
ACGATIGCGC
TCATGAACGC
GGATGATGAA
CTTGAACCGC
GCTTOCCCCT
ATTAAAAAGC
TTATIrCTAT
TAATCAAATA
ACACC"TITA
ACGGC~rAAT
AAAAT'GATIT
GAAGTT'TGAA
CTTAAAATCG
CGCCCATCAT
AAACAGCGCG
ATCCAAAGAA
AGCGAGCAGT
TATCACCACG
ACTOOCCGCT
TATTGGCAAA
TGAAAAGCGA
CAAAAAACAA
AAAAGATCCC
GAAGAAAGCC
AGAGGTTCTA
GATGCGATCG
CTCACCAAAT
TACATTGTCG
CTTAACGCCA
GGGCAAATCA
CTTAAAAAAG
TATTTAGTGG
GGQTTI'CTA
C7TrTGCCTG
GATTGCTGTA
TTTTAAAAT
TTCGCTAAAG
TTAGAAAACT
AAPLTCCATGC
C'T=AAGCG
TCTACTATCC
AACAPLTATCT
AACATGCTCT
TGTATMAA
CACCACAAAC
CTTrATGACG
AGCTATGCGT
AAGCCTTCTA
ACCCCTATGA
TTAATCCAAC
TAGAITAAA.
rI'GCTTrAGA
GTITGCCTGC
TAGGGACGCT
1I''I'ACAAAA
TTATTTTACC
APLCAAGGGGC
AGAGCACTA6A
ATACGCAAAG
GCGCGATCAA
AAAGCGCGCA
TCG'rrGAAAT
TCCTTTTTAA
CCTACAA'TI'
TITCGCACCC
TCGCTGIAC
CAGCTTI=
CCTAT='AG
CTACTTMC
TAGGCG'I GA
CCCTGTTAGA
GCCTGAGCGT
AGGAAAAAGA
T*MAAACCGC
TGGCGAAGAT
AAGATGTTCT
CTTAATGATG
PLGAG LTTATC
AAACGATCTC
CCCCAAAAGC
CCXIT1'AGAT CGCCr11'AAA CCCTI'TTT1
GAACGCTACC
AATCATI'CAC
CCACC~rAAG
AGGCGTTGTG
AAAAATCCC
GTOCCAAACT
AGAAT=I AT
AGAATIGTC
CATITIAAAA
CGGCGTGAAT
GAGCAAGCAT
AGAAATCCAC
AGGCAGAATIG
TGA).ATTGAG
AAAAT=TGC
G~rAATGGCA
ACGGCCCACT
'TrTGCGCTAT
AAGGAAAAAT
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1140 1200 1260 1320 1380 1440 1500 1560 1620 INFORMATION FOR SEQ ID NO:1019: SEQUENCE CMiARACTERISTICS: LENGTH: 1365 base pairs TYPE: nucleic acid STRANDEDNESS: double AMENDZD O
POT/K,
I PEMJS i~JY3~996 TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (gerbomic) Ciii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .136S (xi) SEQUENCE DESCRIPTION: SEQ ID NO;1019
AAGCTTACCG
TGCAAGATCC
AAAGCGCAAG
TTIGAAAGCTT
GATGTCATCA
GAATTAGAAA
CCC ?TTTITA ArTCTCCCCG
CGAGAGAC
T~ITWAACC
CACCACCATTI
AGAGTGATCT
GAAAAAAAAG
TTTGAATTGA
AATGCGAGTT
AATTTATrGA
ATTCTCATTG
AGGATTTATG
AAATACTCTC
GACAGGTTGA
AAAGCCCAT
TT1TAGAGC
GCCTTTGGAG
AGAAAATI'AT
AITICATCCG
GGGCTAAOAT
TAGGCGTAGA
TCCATTCAGC
TCCCTATT
GCGTGTGTGG
CTTGGAGC
CGGATATGAG
CTTI'GCGC
TAGAACGCTT
ATAAAGAAGA
ACATATAA
AAATTTGG
TGGCGATTTT
WITTTTAAAGG
ATGATrACGC
CCAAI'TAT
GCTTAATGGA
TCArITTACC
TAAGCATTA
TGTTAGTCAA
CGGOGATAT
GCTTGAAACC
TATAGGGGGG
CAGCGGATCT
AATI'AATATC
CATATCAAA
GTCTCGTAAA
GGCTCATGGA
GA~TTATTGGG
GATTGTGCCT
ITrCTrCGCT
TCCTTI'A
TATCCAATAC
GGCTTITTG
AAGCGCITI'A
CATAAAAAA
CCACCACCCT
GAATACGCAA
CAATTTAGAA
CGTITATAGC
TAACCCCACC
TGATAATGTG
TACCTATCAG
CCAAAAGTT
ATI'GGCATr
GATATTGCCA
CCGCATGATC
GAAGACAATA
GACGCTTTGT
AAGAGCAGTA
GCGCA'I CTA
GAAGCCGATG
AACACGGAGC
TATAAATATI'
AAAAACTATI'
ATTTAAAAG
GTGTOGGGGT
GATGAATTAA
CGCI'TGATA
ACTGAA.ATro
GAAAAAATTA
GAAT7AAAA
GCGAGTGAAG
TTTATAGACA
GTAGAAACGA
TI'GAGAGGCG
TACTCAAAAA,
CAGGCTTAGC
TA.AGCCCTAG
CAAAAGCGAT
CCGAAATACA
ATTCTATCCT
TCACGGCCAT
AAGAGTTI'GA
AAAGCGATTC
CAGAACATTT
TTITAGACCA
CTAAAGACGC
ACGGAGAGCC
TAGGCGAACA
ATITTAGAAGA.
TTTTGCAAAA
GCACCACTI'1
TAGTGATCTG
AATGTT1-r
TTAAAAGAGA
GGGT'OCGTAA
TTGAAAAAGG
AATG
CCTGCAAGAT
CAAATACCI'
CGT1'AAGTAT
CAACCATCAA
AAGGGCTAAG
TAAAGACAAG
GTI'GAGCGCG
TI'CCAATGTG
AAGTTTITTTA
GGAGCATI'AT
TGCTCAAAAA
CATGTTTA
TACACTTCG
TAACGCCACG
AATflAGAAAT
AAACGATCTC
AAAAAGCGCT
GCAAGCGCAC
AGAGCATTGC
CATGATTTG
AAAGGGGGAT
CTTGTATA
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1140 1200 1260 1320 136S INFORMATION FOR SEQ ID NO:1020: SEQUENCE CHARACTERISTICS: LENGTH: 201 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vO ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .201 7. (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1020 AMEAOED SC CUI/U i PENUS 1 EC 199 6 cGGGTAACCG CCAI1AGG GTGGGACGAA GAGGGCAAGC TCAAG'T1G CACAAATATI' TAGAAACGAG CAACGTGAAT GCCGGGAACG CCCTAACCAA ATGCAAAGAG GCTATTCTAT GAACGCTAGA GCCT7=GCG CGGGCGATGA GAAGCCATTA GCTrGAAAAA A rNFOR.MATION FOR SEQ I0 NO:1021: SEQUENCE CHARACTERISTICS: LENGTH: 558 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1l...S558 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1021
GAAAATCAGG
TCTCATTA
CATGATCAAA
A.AGCTACATC
GGCTTTIGAT
AATAAACTCA
CAAGACTCTA
ATGCGCATTG
GTCGCTCGCA
AACCTCTATG
CGCCATTTTA
TTTAGA.AACG
GTGGATCCCA
CAGCCACGCA
CCTATTICTT
AACTCTTAAA
AAGAAAATGG
TCGGTAIIT
AAATGCAAGA
GGGTGGGACG
AGCAACGTGA
AAAACAAAAC
CAAAATGA.AA
GGATAAGAGC
AACGAGTCAA
CGTGATrI'CT
AGCTCACT
AGGCACCATTI
AAGAGGGCAA
ATGCCGGGAA
CCTATCAATG
TCCGCCCCCA
GAAAACATGA
GAACGCAAGC
CTAGCCTTTIA
AACGATCAAG
AATGGCGAAA
GCTCAAG1'IT
CGCCCTAACC
ATCCTACTTG
TGACTTTGGA
TI'CTAACCAA
CTAGGGGCAT
GTAACGGGGT
CTAAGGAA
ACAGACCCCT
GGGAAAATCA
AATCTCA''
GGAAAIGTC
TTr'IAAGGGC
ATGICTAC
TTTAGAGAC
GGTAGAGCCG
AATCGGCGGT
AAGCGGTAAC
GGCACAAATA
TAATGCAAAG
AGGCTATCT ATGAACGC INFORMATION FOR SEQ ID NO:1.022: SEQUENCE CHARACTERISTICS: LENGTH: 516 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (geriomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION I1.. .516 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1022 TGTTTG TAGI'AAAAT GGTGTTAGGG TITTTGATCC TrI=AAGCCC TTTGTGCGCT PO'fT/US 9 6/ 0 912
IPENU
4 S .LucQ ijSO
ACTGGATTGG
GTOGGGATIT
CTI'AAATCT
AAGAAAAAAC
GATGCGAATA
GTGGAAAATr AGAGAG~rGG
GCGCAAGATT
ATA.1icACA
TGTGGTAT'TT
CCAAACGCTT
TCCTI'AAAGA
AAGAAGCCTA
TGATCAAAAA
TTGAAAGCGT
GCGT1GAATAT
AACAGACAT
TIrGCGCTAAA
AGAAGAGATT
ATI'AGAGCAA
CACGATCACG
TTCTAAGGCG
TITAAAGAT
TTTGAAACAA
ATAGAGCGT
AGATrGCGTT
CAAGCCCAAC
GCCAAAGAAA
CAAAAATACG
TTGATGGAT
CTAAGAOAGA
AGGCTT
CATTrOCA TTAAAcTcAG
AAGCTGAATT
AATACAAAC
TAGAAGTrAA
GTAAAAAAGT
CCTTTG'TrT
TTCCAAAAGC
TAAAGAACAT
GxrATrCT
CAA.AATGGAT
AAAGATCAAA
GTCTIICAAT
120 180 240 300 360 420 480 516 INFORMATION FOR SEQ ID NO:1023: SEQUENCE CHARACTERISTICS: LENGTH: 744 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION I1.. .744 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:l023
ATGCCAAAAAA
GTrGGTTTAG
CCCCCTATCC
ATO"GGGAAA.A
GAGGAATGGC
AAGGCTTCTA
AGAATCCATG
AAACCCCATIG
AAAAGCGAGA
GGGTATI'ACT
CTCAAAACT'
CCTI'ATAAAA
AATAAGCCTG
OTATATI'CAA
ACGATAAAAA
AGTTAAGGCT
OCACOCACTA
TAGGAGTCGC
TTGAAAACAG
ATTTATATGA
AGCAT3AAAT
ATAAAAAGGG
TGCAAAT~G
TCCCTCACCA
CCAAAGAAGA
CGTTGGTAGA
AATAACTCTG
AGCAGCTCCT
CGATCAAGCC
TGAGI'CCCT
CCATGAAGAA
CCCGATI'AT
?ITIATATA
GGCCCTCAAC
CTTAACAAAA
GGC?TI'TA
AATGGAGGAA
AGCCCTAAAA
GAAG
T G GGTTT
AAAAGCGTTC
TATGAAGACC
AAAATTAAAG
TGTGTGGCGT
AAGAATrcCT
GAGGGCAAAA
AAATCCCAAC
CCTAGCTrGA
AATTCGCCCA
A.AAGACTCCC
CAGCTTrOAAA
TCCTCTITT
AAAATACCCC
TTATCAAAAT
AAATCCTAGA
TAGTCATGTT
ATIGAAGCTITA
AAGTGAAAAG
CCTTAAAAAA
AAGACGCAAA
GTAAGGATTT
TCACGCATI'A
ATGCGGCTAA
AAGGAATGCT
TAAAAA'ITrA
GTTAGACAAT
ACAAAGCGAA
AATAAGCCCT
TGTGAAACAA
AAAAATCAAG
GGAACCGCCT
GATCCCTAAA
?rrCAAACG ?I T2ATTGGC
AAGCTTTAAA,
120 180 240 300 360 420 480 540 600 660 720 744 INFORMATION FOR SEQ 1D NO:1024: SEQUENCE CHARACTERISTICS: Lr_ NGTH: 681 bass pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori POUS 96/09122 IPENUS IPiDEC 1996 755 (ix) FEATURE- NAME/KEY: misc_feature LOCATION .681 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1024
AGTGGATOCT
CAAAAAAWDG
TTAGGTTATI'
AAAATCACTC
AATATCAC'7A TATG=I.. .r
A.AACCATI'AG
A.AAAATGGCG
GGCTACACI'
GCCGTI'ACCA
GAATACATCA
ATI TGAATC
GCGTGATCGT
ATCTI'AAAAA
TCAT GTAGA
CCTITGATGAA
TGGCGATTGA
GCATCACGCT
ATAAGATI'CC
TCGCCTCTGA
GTCGGGTAAC
CCAAACCTTrA
CAACTCTGAT
GGATTA'T=
CACTAGAGGC
TGTOGGGG'CG
CGAGTCAGAA
TGACAGCAGC
CTTAGAGGCC
GGACGCTAT
AGTGCGTAAA
TAAAACGGAC
TAGCGGTGAA
OT*OTATGTOG
ATCGGTCAAG
ATrGCTGGCG
ATGATGGAAA
AACACGAAAA
ACOGACAGAG
ACTAACGGCT
TTAGTGGATA
TACAATAAAT
AGAATGCGCG
TAII'AACCA
TATCATTGG
AAGAAGTGGT
CTACGGTGAG
TGGCAAAGAG
GCAAAAATTC
CGATTATCCG
TAGAGGGCTT
'ITGAGATGCC
TCAAAAACCT
GCGI'GAATC
CCGTAGTGAA
CIGGC COAT
CATCAAGTCT
GGGCGATGGG
CATI'AAAGTC
TCCTAGCGAT
CAAATGTTTA
AGAAATGCTC
TAAAATGGAT
GCCCTATC
CGGCATGACT
GCGCAGCATI'
AAATTAGAAG GAGACCAATC G INFORMATION FOR SEQ ID NO:1025: SEQUENCE CHARACTERISTICS: LENGTH: 828 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-..feature LOCATION .828 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:lO2S
ATGACCCTI'
GGGGGGTTAG
CACACGCATO
GGAAAGCQT1' CGCTCTT1'
CAAAAAGCCC
GGGAGCGGAT
AGCGATATT
AAAGAGCGTG3
CTGTCTCTA
GAACCGCACG
TTTTAGCCG
AAGAGCI'GA
AGCGGCTTG
CACAAGCCCT
AGTCTOAAAT
AGCATI'GGA
TGAATIGACTG
TCGTGAATGA
TTAATATTAT
GCGTGTCCGT
CACCAAAAGC
~~TTTTAAA
ACCCGCCCTA
AAGCCCI'rT
CTAAATI'AAA
AAGAATGCT'r
ATAGAGGGT
AAATAA.AGCC
?I'IWITAGGC
ATTAAGCCAC
CCCCATAGAG
GCATCTITI'A
TTCTCAATAC
GAGTT TGGCT rIVITAGAAGTC
ACAAACGCGC
TATCGCTAGA
TOGGGGGGTT
AATCCCTT
GGAGITTGC
TGTGGGCGTT
AAAAAAGAAT
'TrTGTCT1'GC
GAAGAAGAAA
TATTTATTAG
ATCCCACGGC
CATTTAAAAG
T'TAGAAAACC
GCGTrAAAAA
CTTTGGATC
AATTATCCTT
AAAGGCGATIG
GGTTATGATG
TTAAAAAGTI'
TATCGCCAAA
AAAAAGAAAG
CACGCI 7M
GAAGCTGTGA
CTGAAACCGA
AAATAGGCGA
CTAATCTCTC
ATATIGAACG
ATATGCCAAC
TGGAAAAATV
AAATCTTAAA
AAATrjGGGTA
CAGAGTMTA
TTTTAAGA
AGGCTTT'AGG
GGTrITTITG TGAATrIGGTA
TTTATGGG
GAT1'IAGTC
AATCGGCATA
TATTTATOGCG
CI'1rTCTA
GATAGAAATG
CGTTCTCAAA
AGAAATCGT
T13ACCAGTTA
CAAGGATTTG
120 180 240 300 360 420 480 540 600 660 720 780 828 INFORMATION FOR SEQ ID NO:1026: SEQUENCE CHARACTERISTICS: LENGTH: 564 base pairs TYPE: nucleic acid STRANDEDNESS: double ~~i~uiUq 9 ,QJ 756 (D TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (geflomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAM/KEY: misc_feature LOCATION .S64 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1026
AAAGCCGTGT
AAGCGTTTI'
TTGTTTTCT
ACCGCTGATG
TIAAAAATCT
AGAGTCAAGT
AAAACCCC'T
AACCGCI'AG
CCCCTrI'ATA
GCCATGTGGC
TGTTCAACCC
TAATCGTTA
'TTATGCGAA
CGATCGCTAA
TAGAAGAACG
TTTCTAATAT
ATITTGCGCT
GGGTTTCTAA
AAATGATAGG
TITATAAAAT
ACTACCAACA
TACCCTTTCT
AAATAACCTT
AAGCCTTITA
ATrCAAAAAC
CGGGGTGTI'
TAAAAAACAG
AATCATTATT
CTATGTGT
CCCA
AAAAGGTCCG
ACCTI'GCTI'I
TGGAAAACA
GAATTAAATA
ACCCCCIIG
GTGGCCTCT
GGCTTACC
GCAGAAGAAG
TTGGGCGCGA
TCATGCCCCA
TAGTGGGGGT
CCCAAATACG
ATGCCTCTTC
~TTGTTGGA
TTAAAAATG3A
TCACAGACAG
AAATTCAAAA
GI'IGTITT
TTIGTAGCG
CATOCAATAC
TTTAGAGCCT
CGCAGACAAC
CGCCTTAATC
CGCCCCAACT
AATCTTTZATC
CGCGCTAATA
INFORMATION FOR SEQ ID NO:1027: Wi SEQUENCE CHARACTERISTICS: LENGTH: 1224 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (1i) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAE/KEY: misc-.feature LOCATION .1224 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1027
AATATGC'ITG
ACTCCTI'ACA
AAGCCTGTTT
ATGCAA'rrAT TTGGTTTGrA
TACTTGGTGT
TACTATACTA
T7I TTAAGG
TACACTCTCA
CTGT1. GT
CAATTCACCC
GTGGGTI'A
iAACGCGTATT
ATATATGGAT
TTGTAGGCCA
TACTCCCACA
CCATI'ATC
COCATTI'AGA
TCCTTGTr CCATGCATTfl A'TTrTCAA
TAATGATCAT
TCATGATT
CC'ITGAATAA
AATCTCAAGG
TTGGAGGCTT
AGATATGATA
TAI"I GCAA
AAAGGATI'AT
TCAAATITTA
AGATCTCACG
GTITTAGCG
GGATAAGGAA
AGGAI'ATTG
TGAACATGTG
GGCTAATC'T
TAGGGATTTA
CATC~TTGTG
GGGTAAAAAC
ATCTGTA TI' TTGAAATI'rA
GAAGAAGCGG
GATGGGGTGA
CATTATTTAA
ATTCAAAGCG
TTTGGCTITTT
CTCAC'TTTAG
GAGCATTGGG
TTTTACCCTA
GAAAGTCAAA
ATGGACGCTA
AAGCGGGTGG
TTTATTTGCT
TCCGTCAAAA
GAAATTATGC
TCITTGC!TGG
ACCTTCCTGA
TTTTAGCT
CTAAGGTGAG
GCGTGGGGTT
AGATCAGCTC
AAATCGCCCA
TTGAGAGCAT
GCAAGAGGGA
TGTTGTTGA
CTTTTACG
ACTCTGCGAG
TATTAGGAAA
TTGGGTC7Z'r
AACGCTAGGT
ACCCATIAGC
TTrATCGTTG G'rrGTTGATT
GTTTTGTC
GCTTCAAC
GATGGATAAG
TGGGCGTTTG
CACTTTGATC
120 180 240 300 360 420 480 540 600 660 720 780 I PENUS 1396 TCTAAAGT'1'
AATAAGGAT
=TATCGCTC
AGrrI'ATCA ATT-rGGG'I-IT
TCTAAAGAGA
TA'IFCGCACC
GGACAGAAGG
TGTTGAA)AA
ATTI GCCGCC
CGATTCTACT
TTAGCC~CAA
cTrI'AGCCAA C7=I'ATGT rGCTrTTAGCC
TTTAGGGA'
cTTGT~rrrTG
GAACGAATAC
AGCGTTAGTIG
TTr CTTGCAT
ATTTTAGGGC
ATGGGAGGCT
GAAGGC7 r A
CCGGTGTTI'T
AATGCGGACA
TCCAI GTGA
TCACGCACC
ATGAGTTAGG
TGCTCGCTCT
ATGTCTCOCA
CCTIACGC
AGT77rGGGGC
ATGAAAATAA
CGCCGCTA'I'I
GCArI:1A1A TOI'TI CT
AACGCCAGCG
CATGCCTITG
GAGTAAGC
AGCGTTCCCC
AGAACGCCTA
840 900 960 1020 1080 1140 1200 1224 AAAGC7TFGG ATTATGAAAT TGAA INFORMATION FOR SEQ ID NO:1028: SEQUENCE CHARACTERISTICS: LENGTH: 432 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...432 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1028
ATTAGAAGGA
GCTAATGCAA
ATZGGCOATG
GOCTACACC
AATGTCTTCC
AAAGACACTC
TCMTGGACTGCA
ATAACAATAA
GACCAATCGT
GCTCTAAACA
AAGAATACGC
GAGTCCCTGA
C=r'ATCAG
GTTATTTGGT
TGCCATCCGA
GAGCAATCAA
AGAAGACAAT
CATTCCCAI'
AACCCCAAAC
TTTGCGT1'TA
GGTACGCCAT
ATCAGCATCC
T'AAAAGAT
GAAGAAATrI'
TTGAATATT
TATGTGCT'G
AAGI'TGGCT
AACGATCGAT
ACTA7ITGACC
TATTTGAAAG
TGCAATTCAT
TAGAGATCGT
GCGTGTI'CAA.
TGAAAGCCGA
CGCTGGGI'1
CGTCGCAGAA
ACAAAAAGAA
TGGCTTTAT
CAAACCCATT
T IAAGGGGC
AAAACAAAAC
TTCATCGCTT
ACTGTGCGCG
INFORMATION FOR SEQ ID NO:1029: SEQUENCE CHARACTERISTICS: LENGTH: 897 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc-feature LOCATION .897 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1.029 lzziv ARPFl1O SHEET'.
POT/US3 I PEMJS1 -0 =6~ TCGC~rTcTA
AAAATTIGTCA
ATCAGcTACA
GCTCAG'LTAG
ACccTTGAA-A
ATGCTCTCTG
AATAATAATG
ACCGCACTCA
GATCCCTAT
CTAATGGGCA
TTTTATACTG
AGGATTTTAA
GATAAAAGAG
TACCATTCAT
G.AAGAAAAAG
T'CAATAGTT
TGATGGTGTG
AGGTI'GAAAG
TCAGTTAA.
GGT'TITAAG
AGTT7GT
AACGAATGAT
ATGAAAACAT
ATAAAGAGGT
AGAATCAAAA
ATGT'GGTAGG
TCAACCCTAA
TCGCTAAAGC
TGAGCGGGAA
GGAATAACGG
TA.AAAAGGCA
TGCGGTrGTr cGTGTTGCAA
AATTCAAGGC
cCATGCAAAAT
AGCAAACCCT
CACTGCAATG
GACCAACCAA
TA-ATGCGAT
TG7I'ATAGGC cAAGAAAAAG
TCGTGAGAITI
TGTGGAGTAT
TACAGAAACC
ccAATcA=G
AAGGOAATGA
ATGITCATI'A
AGCCAAGCCA
ATrATGAAGC
GGCGCTATTA
CATGTGTTAT
AACATGGAI'
ATCCATTCGC
AAAATCTATIG
GCGCTCAA'rr
AGCAACACCT
CAAGATAAGA
TACAATCAAA
GCGTTGGGCA
AATCTACAAG
GCGCTGTTAT
CAGAATTGCT
GCATTTTAT
ATGACACCCT
TGGTTAGCGC
CAAAAATCGC
TCAAAAGTAT
GCATGGACAT
TCTTTTA
TITTTAATGGG
TI 'TAAGCGC
ACGAAGCGGG
TACAGCCCT
ATrGGGAA.AT AArIrGGrT
G-CGTTAT
GCAAAAAAAA
GGGCGCTA.AC
AAAAAGACGC
GATTTATACG
CTACCCTAAT
AACCCGTrCA TACC CTC CCC
CATTGACGCT
GAAAGACGGC
TATCAATCCG
CACTTTGAGC
TGATITZTI'
ATGTCAA
120 180 240 300 360 420 480 540 600 660 720 780 840 897 INFORMATION FOR SEQ 1D NO:1030: SEQUENCE CHARACTERISTICS: LENGTH: 303 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc-feature LOCATION .303 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1030
GGGGTA~TT'
TACCGC'II'
AAAAATGCCC
rTTrrGCTCT CGCA'I GATT
CCC
ACAATAGCTC
TAAAGAGATT
TTAGC Tv TGG.IrAAGCC TCM TGATAA
TCTCCCACAG
ATCACTTATT
TTTCTrCTAT
GCATGTAAAG
CCCCCAACTA
TATOCAAGCT
TTACTCATGC
CTTTGATT
GITTTATCATC
AAAACCCCCT
CTTTATTGT
TTAATAAGCC
TGGTGGCTCA
ATCAAAAGCA
AACCCGAGAA
ATTTATTTTA
AAAGccTTTA
TTGAGCACT
CCACCACAAG
INFORMATION FOR SEQ ID NO:1031: SEQUENCE CHARACTERISTICS: LENGTH: 333 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (Iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE: NO ORIGINAL SOURCE: ORGANISM: Helicobacter pylori v q4r1_z_
POUS
APNUS
1E ~DC 996 7S9 (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1 .333 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1031
TATCACTG
CATGGCATGG
CATGGCGTAA
AACCGAGTGG
GTGAGGATTG
GGTGCTAAAG,
CGATAGAAAT
GTGTGGTGAT
CTCTGGGGGG
TAGTTGGGGC
GGGCTAATGC
CCAAAACCAT
CCACCCGGGC
TGGCGAGACC
TACGGGCAAG
AGGGGCTAAG
GGTGGTGCTI'
CACAAAGGAT
GCTAAGATTG
ACAGAGATrG
TTTIAAGGGCA
GTCTIGGGCG
TCAGATI'IAC
CGT
GGAGAGGGCT
GAGATOATGT
AACGCCACCC
CGATUI'GCGT
CCACGGGI'C
TTA~TTGAT
TACCATrAT TACTT1'AGGC
GGGCGATGAT
TACGGCTGTA
120 180 240 300 333 INFORMATION FOR SEQ ID NO:1032: SEQUENCE CHARACTERISTICS: LENGTH: 1131 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-.feature LOCATION 1 .1131 (xi) SEQUENCE DESCRIPTION: SEQ 10 NO:1032
GTCAACTCCA
ACTAAACTCA
GCCCATGACA
ACCGTGGGCT
GCTAGAATGG
TCTGTAACTG
GTTGTI=A
ATGAAAAAA
AAAAAT
T
ITCA
TGCGGAAAAT
ArATTG
GGCTATATCC
GGGAGTGCTA
TTATGCG
GGCGGTCAAA
GTTTAGATOG
ATCTATCAAA
GAACGCTGTG
TAGGTGTI'AA
AAGTGCAAAC
AAGACAACCA
CTGAGATCAT
TTAGT=rTr
TACTCCCTAC
GAGTOATCAG
AAAGCCTTTC
TCACTCTCCA
ACCTCACCAT
CCACGCTGGC
ATAACACCCT
CCCAAAATAT
TAGATGAAAA
AGCATGAGG
AACAGCGCAT
AAGCCACTTC
TCGCTAAAAA
AAGTCATCAT
AAAAGTTA?1' GCrI'AAAGTC
CGAAGAAGCC
7rACTCCACT
GATI'IAGCG
CAT='TATG
CTATTATAAT
TAAGACCATC
AAACATTTCA
TCAAAAAGGT
GGATATTATT
ITTAACCAGC
TTACCTIT
ACGCITGAT1'
CCTI'AAAACC
AGGCATCGCA
AGCCCTAGAC
TAAA.ACCCTA
TGACATGAGC
ITTTTCAAAAT
CACAAACTT
TGCAAGTOG
GTCGCTTACA
TATGCCCTAG
GAAATCGCTT
GTTGAAGAGG
T1'CGCTrATA
CAAAAAATCG
ATGGGGC~rA
GAAA.ACAGGC
GATOOCACTOG
AAGGTGTGCA
CAAGTGGGCG
AGAGCCTTAT
AATCAAACCG
ATCGTrATCG
CAACACAAAG
AAAAAAAGGG
ITTTTCAGCAA
TIGGAGAAAA
TCCCCAGGTA
TCTrATICAA
CGCTI'TATCG
ACAACCAGCT
ATI'IAGTCCC
AGTCAAAACA
CTCTCATAGQ
CCTACCCTAA
GCTCATGGCG
TWGGOATAA
AAATrGCTCA
AAGGGGGCGC
ACCATAACCC
AGAGTAAAAT
CCCACCGCI'
ACAATCTCGG
TGAGATGGTC
ITTCAAAATC
TAGCCGTAA.A
I'rCAATAGAA
ATACGGCGAA
CATACTCCCT
TGCAACCAAT
TTTAGACTI'r
CCCGGTTTA
CCATAGCGGG
A.AGT GGGAA
TAAAAAAATA
TATCGC rrv
TATCTATGAT
TAAGCTTAGC
TGAAATTG
CATGGATGAA
AAGCACGATT
C
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1131 INFORMATION FOR SEQ ID NO:1033: SE, JENCE CHARACTERISTICS: LENGTH: 687 base pairs TYPE: nucleic acid STRANDONESS: double
PGTUS
iPENLJS 96/0912?' tYTOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION 1 .687 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1033
GCCTATAAAA
ATTTTGACA
AACGATAGTA
TCAAGGAATG
GAAGAAATAG
AGGGGGCAT
TTCCATATCG
ATI'ACTAAGT
AATATCATI'C
AATGATTATG
'TAAAAT
i. i GATTTAC
AAGGGGAAAT
GCAfGCA7I'T
AAGAGGGT
AAAAGATCCA
ATGCAT AGC
TGAATAGCGA
CTCAGCGGC
ATTTAAGAG
AAAAATACGC
AAAGCGCTAA
TAGTGGGGCA
AAAACI'CGC
CATGGCGCTT
AAAATATGAA
GAAACAATTTI
ATATTTTTAT
CCTAGAGTTTI
AGTGATGGCG
CTrGCATAGC
CGT'GAAGG
CTATCACCCA
GGCTAATAAA
AGATGGCTAT
AAAAGAG
GAAGTGGTTTI
GGGTAAGG
GAAGTTTATC
AACGAGAT
GGCGCTATCA
TTTATTGATA
GAATI'GCAAG
AGTCCGCCTG
AGCCGTATGC
GTGGCGTTTT~
CAAGGGAAGT
TATGGGA'TrT CG'rrGTTrCA
ACTATCAAAG
TAAAAACCCC
TAGAGCAAAA
AGCA'ITATCA
TGTTGTGCGA
ATAAACCCAA
TAATGATAGG
TGGGCTATAA
ATTTGAQAG
TGATGGCWG
AAAGCATGGC
TGGGGGGATI!
TATCGCTCAA
GC'TTIGAT
AAITATATT
GTI'AGGG,
GATI'ATCGCT
CGATAGCGTC
CAGCAAGGTT
CT TAAGGGG 120 180 240 300 360 420 480 540 600 660 687 INFORMATION FOR SEQ I0 NO:1034: SEQUENCE CHARACTERISTICS: LENGTH: 495 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTF7TICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc...featuro LOCATION .495 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1034
AATAAAAGCA
GCACAAGAAT
GAGAGGGTGG
ATGTTl'GAAA
ACCGGTGG
AAAATGGAT
CTTTTGAATA
AAAAACGCTTI
,CTACAATTCA
TGCAGCATTI'
TGGCTGG3C
GCTTGAGCGT
AAAATTGAT
GCA?1'GTGAT
TTGAGACCTI'I
ACCTCACTCA
CCTATCAT
TCOCA
AGTCTI'AATC
?I'TCAAATTA
GAGAGGGAI'
TGATGAATTA
GCATGAAAAT
GATrAAGCGT
AGCCAAAGAG
TGATGCAAGG
GGTITATG
GAAGTOCTG
'TrTGAAGAGC
AAAACGCTCA
CTTAAGGGOT
TTGAATCAAA
CTTI'TGAAA
GGTGGTI'AA
GGAGCGGTAA
ATACGGATAT
TTGGCGAAGA
AAACCCCCCA
TAGGCACAAC
AAGAAAGGGA
AACGACAAGC
ATAA?1'CTIT
AAGCTCTCTA
GATCATTAGC
CAATTTCAGQ-
TATCATI'rCT ?1-rrrACCTC
AAAACGCCCC
CCTCTATGAA
AA.AACAAGTG
PI M 6 DEC 1996 INFORMATrION FOR SEQ 10 NO:1035: SEQUENCE CHARACTERISTICS: LENGTH: 975 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECUTLE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vO ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .975 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1035
ACCGAGTTAT
GAAATCACT
CCAAAAAGTT
AAAGACCAGG
GAATCGCATG
TGCATI'ITAA
TACCCGGTGT
AGGGTGGCGA
ATGGTCATGT
?AATGCATTIT
GTITI'CCACC
ATTTTTCAAG
ACCATCATCA
GTGTTTAAAT
GGCGTGOCGG
CCCAAACGAG
AAGGCCTI'GT
ACGCCTACCT
TGGATTATT
GGCATAAGGA
TCAGTTTTAG
CCCACCCCTA
ATCATCAAAA
TGAAATCAG
ATTIATOAT
CTAGCTITG
CCATTGTGCT
AAGAAGTGTT
GGTTIAGG
TCAGCGTGAG
TGCTI'GAT
AACGC
GATGI'AAGT
CACTTATTTG
AAACAGGCAA
AGACGCTAAG
AGGGCTAT'IA
CGATAAGTAT
TCCrI'CTAAA
TAACGATCTA
CTCGCCTTCA
TTCTATCATG
GACAGCGATC
TTTAACCCTA
GGGTAAAAAT
CTCTATCATT
CGAGCCGGAT
CAGTTTGCG
AGAGACATTG
TTICGCACA
ATCAGTAAGA
GGCATGCTCA
GAGCATGAT
TXTIIATC
AAAGGGAACC
GCGTI'TGTGG
AAGTATTTA
CTCACTI'TAG
GTGCATI'A
GCTTTAGCCA
ACGGOACA
ATCGCATTAG
AAAATCACrI!
ATTTATGTTA
TCCAATATTC
ATATCCGCAA
TGCAAGCTGA
TGCII'AAGCC
TAACAGAAGG
AAGCCGTGAA
ATTGTAGT
TGTGCTTGCA
AAACTIAG
TGTCGCTGCT
GCAGTTTGA
CCITTGATTTI
ACCACCATOC
CCAI'GAAGC
ATGCGGTGTA
AATI'CGCTTA
CAAGATCCGC
CCACCTTCCT
A.ATCAAAATrG
AAGCCAATIT
GATTGAAT'A
TGAAAAGCGT
GAGCGCGTCT
AATCCCT=
CGAAGGGAGC
TITTATT~CGTG
CATTAAAGAA
GGTCAAGGCG
GATCCACCGC
GTTAATGCTC
TIGGCTATC
TACCGTGTTG
INFORMATION FOR SEQ ID NO:lO36: SEQUENCE CHARACTERISTICS: LENGTH: 592 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO NOi ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .592 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1036 PCT/US 9 6/0o91 2 IFPEAiS 10 199 6
CACAGTTATC
GTTrGTAGGA
CAACGTCAGC
AGGATCGCAA
GCATTTATCG
'ITAGGGCGA
CTrTGI'GTC
TATITATTT
TCCGGI'rAAA
GCGTT-ZTAAA
AAACGGTAr ACCT GCGCGT
AGTAGCTTT
AAACCCATTG
TI'CCACCATC
ATAGGGTTT
GGCATGATCA
ATTCGATCG
GAAGAAATCA
TACACGCCAG
CTGTGAGTITC
CTATGGGGCT
TGGGGCAAGC
AAATCATT
AGCCAGAAT
CTATGGCGT
TGAAAACCCA
GGTTTGTGG
GCCTGGCC7I'
AGGTATTATC
ACAAATCAAA
TACCATGGCG
CCTTTTATrG A'I GTGGAT
AGCTAAAAAC
CCCTATTITA
CCCTCAATC
CATTA'TITA
TAGCOTTATT
AGCGG'I GTT
ATAACAAGAG
AGTGCTTATG
TI'AGCGAT
CACAGCTrAA A-rGTCAAAG
TGCTTGGTGT
AACCTGCTCG
ATCGCTTCGG
AGTAAAATCT
TAGACGAOCT
GGGTGAI'GT
ATCCCXT=r
TAATTAT
AAGCCGTCCC
CCTITTTCACA
TATI'GACCGA
CTATCGGGT'
CTATCATGGW
INFORMATION FOR SEQ ID NO:1037: SEQUENCE CHARACTERISTICS: LENGTH: 1332 bass pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_featur.
LOCATION I1.. .1332 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1037.
CGGTTTGOC
AG7TTITGGAG
AACGAAATGC
GAI'ATAGAG
AAT7Z'AGAAA
GCTGAAGTGT
GTOC'TITATA
GGTITTATTAT
GAGTTAAGAT
AAGCAAAAAG
AATGCGATGA
CCTATCACTA
rTTI'CATCTA
CTCGCTTCCA
AAGATTGAAA
TCAAATTACA
CrrrCTCTAT
CGTTCGCTTA
CCCATTACCA
CCATAGAAGA
AGG'TITI'AGC
TTAAATTCAG
AAGATI GCA
TGATTTTATT
CTCAAGTGAA
ATGAAATAGG
ATGAATCTCG
AGGGCAAGAT
TATI'TGATCA
AAAATI'ATG3Q
A
4
AATCTTT
TCATTAAGC
CTI"ZTI'AAA
CTATCGTG
GTTTGTTACC
?I'ACCTCTAT
CAAAAGACGC
CCATATGG?1'
TTCGGTTTCT
CCTCTTTTI'A
ACGC7I'CGCT
GGATI'TGGCT
GGTTATTT
ACTAAGCTCT
CTTAACATO
GAGCAATAAA
AATTGATGAA
GGATI'IT GAA
CGATGACAAA
CAAACC7I'rA
CAGCCAAGCC
GGGATTGAAT
CGTTTTI'AAT
ATTflGAGAGA G TGTCGCT
TCTCTCAA.A
ACTATCAATG
AAAATTGGCT
CACCAGTTGC
TATAGGAATT
TTTGTTGC
CAAOGGGATA
AACGAA'TITG
TTGCGCTCTA
ATGCTCAAAG
TTGATTGAGC
GAAAA.A Trr
GATAAAAAAA
TTGTTTGCTA
CAGGTGTIThII
AAAZAAGAIT
CATGGGTG
TTGAGCTATC
AGTTITrACG
GGTGAAGGGA
TGTTTATGAT
TCAGTCACGA
?TAGAGAAAC
ACCACAGAAA
TAAAAAAGGA
A'TrCTTAGC
AGAGTTTATT
AAAGCGTGAG
ACAATTGCAT
TCATGCATGA
AAGAGCTGTC
AMTTGCCCG
TA.ATGAGCGA
GCCCTATCCA
TAGCGITIAAA
TGGATTTCAT
TTGAAAAGTA
GGTTAGGCAT
ATTATAGCAA
ATTTAGAAGC
ATGAAGGGAA
AACGCTCTTT
A~AACTATCAA
IAACTACTCT
CACAATAGAA
TATI GGTAT TGAGCATIT1T
CATTACGGTG
GCCTTTAAGA
TTGTAAAAGC
CCAAAAAATC
ATTACGCACC
TTCAAACGC
CATTGAGCAG
ITT71ATAGAT
TGTATCCTCT
AAACATC2ATA
AGGGAATAAT
TI'TGCAACCC
GTATATCATT
TGGAAGAATC
GGATAAT GAA
CAGAAA.AAGC
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1140 1200 1260 1320 1332 GACAATGCGA TCAAATACAG TTAGTGOTGT CCAATAAAAG TACITITAAAT CTI'CTAACCC AAAAACGCT TAGAGGCTAT TG'TICACTA TCCATGATI'G GAGCTACCCC CCCCCCGAAA CAATTGTGGG GT INFORMATION FOR SEQ ID NO:1038: SEQUENCE CHARACTERISTICS: LENGTH: 990 base pairs TYPE: nucleic acid
PPTIQ
RPEAMS
09122 2 Th 3 ~b (C STRANDEDNESS: double -OPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION 990 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1038
AGAAAAACAA
TTAAGAGCGA
GTCATAGAAA
ATGAGTATAG
GTTTTATTGT
GATCACATTG
ATAGCGGATT
GCTTCTGTGT
GAAAGCGGTG
AGAAAAGCAC
TTTGCGAGCA
GATCGCAAAA
GAAGATGAAA
ATTGTI'AAAG
GAATACGCCA
TTAGAAACGA
AAAGAAGTGG
AAAGAGAGAA
TGGTGAGAGA
GCGATAGCGG
AGCCTCTTT
TTGGCATI'CC
TCGCAAAAGC
TGTG?1=
CTAACGATAA
TGGATATCT
TOGATAAGGC
GTTATTACGG
GCTATCAAAT
AACAGGGTGC
AAATCAGAGA
TGCTCAAACT
TGAPCTIGLTI
CTAACTTAT
CATGTI'CAAA
AACACGTTTA
TATIAAAAAC
AAAAGAATGC
TAAACATAAG
TACCGAGAA
CGAATACACC
AACGCTAAAG
AGCTCCAAGC
CGGGTATITIT
GCCTTI'AGA.
GGAI'ACGCT
GGATATTTTA
TCACACTTTG
CGCTCAAAAA
TAAAAGAGCG
ACAA.AGGAAT
CGATTGAGAA
AATATTAATG
GAAATCAGCT
GAAGAATTAG
GACGCTACAG
ATAAAAAAC
GACCATGGGC
ATTTTAAATC
AACATGATG
CACACGCCCA
GATGTAGCCA
AACCAAAAAG
ATGGTGAAGC
CTCCCTTTAG
CACAACCTGA
GGAGCGGATA
GATACGAAG
ATTCATCGC
CCATGCCTGG
TGGGTI'TAGG
GAAGCCATGC
GArI'TAAGGA
ATTGCGGGAT
TI'CAAGGGCT
ATGGCAATGT
TCATGAGTTA
ATCTCCGCC
AAGCGCTIT
CGGCTITAGC
CGCTCTATAA
TCAACTATGA
TGATTATTAG
CAGCGAAAAT
TCCCTI'ATT
CGTGTATCAA
CATAAAAGCC
G ETAAATAAG TTrGATCG?1'
TTAGAAAAC
TAITTTGGCT
TITAAGCTI'G
TTCCACTAAA
GAGTTTTG'GC
AGAAAGCTG
GTATCTGGAT
TGTGAGTGGG
AAGCGTTTTA
CTATCATGCT
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 990 INFORMATION FOR SEQ ID NO:1039: SEQUENCE CHARACTERISTICS: LENGTH: 1086 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-.feature LOCATION .1086 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1039
AGCGCAGGGC
CAAAGCGCTA
ATCCAACACA
AGCATGCTAG
GCATr *GGC
TGGACGGCTA.
TCTTTGCCGG
TGACTGGAGC
AGAGTCATAA
AGAGGATATT
TGGGTTTAAA.
GGATGATGTG
GATGGTGCCA
AGATTTCGCC
ATTTGCGTTC
ATGCAAGACT
AGCGCTTTAG
AAGOCAATAG
CTAGCTCCTA
ACGCTI GCC
TGGGCCAAAA
AAGTCAAAGA
AAACGATCGT
AAGAITITAA
TAAATTCAAT
AACTCAAGTI'
AAATGAATGC
TCCCATAGAA
AATTCACGCT
120 180 240 300 PCT/U S I9 09 12aa i PEAIUS 16 DE C1996
AATATCCGTC
CGTTTGAAT
TTT'AGAAAAT
AACGCCCTAG
AAcTAcAACA CTTGAATrGC
G;ACTTTTTA
CTCAAACCTG
CCGGGTAATC
cGcTATCCT
TTAAAGCTTA
ATTCCTTACA
ATCGCTT1'AA
GAAAAT
.AAAAGGGCGA
ATCYOCCATAT
TAAAAATCGC
AGTGCCAGGT
CGCATTCT
AAGGCTATGA
MAGACGCT
GAAAGCCGGT
c'I=AAGTTrG
TAAATAAAGA
ATAACAAACG
ACAACCGCTA
TTGATGAAGG
GAACGCTI'CT
CGCGCTCATI'
TCTCT1'TAGT
TTATGATGT
AGGGG 1-11 A
TGTCATCCTI'
GAAAGAAAGA
AACTTTAGCC
C?1'ACTGGT! 'I'rI'AAATTA
GACGCATTTA
T3AATCAGGA
AGTGGGATTG
TTAAACAGCG
GCCTCTCAAG
AGCGGCGATG
AArrCAGTGG
AAAGATOGATA
TCAAGTGCGG
Ancccr
CAACTCAATC
TTACGAGTTT
AAACCCTTTA
ATC 'TAGGCA
GCGATTCAAG
GTTCAGGGCG
TTTTAGTCCC
GTCAAAGA
AATTAGTGCC
GTGTTTTTAA
AAAATTACA
GGGT'0AGCGT
TTATACGA
AAAGCAITAT
TGATTCTACC
AGGCTCAAAT
ACTATCAAA
CCCTT'GCGCA
AAATTGAAAT
TAAAAATACC
AATCAAAGCG
TTrAGGGCAA
CATOCTTAAA
GC'rrAAAATA
AGGGGATAAA
AAAAGTCAAT
TATAGGC7I'A C LTATTIGGAG
CAATGCCCCT
CCACCAATTC
AGTGGATTCT
TTTAAGG7I~r 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1086 INFORMATION FOR SEQ ID NO:1040: SEQUENCE CHARACTERISTICS: LENGTH: 633 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .633 (xi) SEQUENCE DESCRIPTION: SEQ ID NO;1040
GGGAATTACG
TTGGTGGCGG
TCCAAGAAT
GTGGA ITTGC
GATGGCTCTA
TTAAAAC?1'r GAl TMYGAT
CGCTCTITG
GATAI'1TATC CACAAkAGATT
GAAAAAAACG
GCCTAGAGAT
'M~rAAGCGT
TCCAAGGGG
CCACGAGCGC
TCCATITCTAA
CCCAACACAC
T1'rAATGGC
TGTTAGTCAA
AAAACATGGA
ATTACCGCAT
GGGCGTATGA
TAGATTTAAG
TTATAGCC
CTTTAGCGGG
TAGGATCTTA
AGTCGTGGGT
CCTTAATCAA
AAACAACACG
TCCTTATAGA
TI'TAAACCAG
CACGCTCATT
ATTAAAACTG
GAAATGGCAG.
AGAGACAACC
ATCTATGATG
AAAAAAATCA
ATTGATAAAA
GACGCCTTG
ATGATTTTGC
ATCGTGTITAG
AAGTTTTTr
TTAGACOGGA
AAA
CTrI'TGAGCC
ACTACCTCAA
CGCTCACTTA
GCATrGATTG
AAAAACGCTA
GTTCCCCTTA
ACACGCAAAA
CTcACATTAA
AATACCGCTA
GATCATAGGT
TGAAATCAAT
AGAAATC CAT
CCAAGATATT
GCACTACCCC
CCAGATCCAA
TAAAATL'ITG
AGGCCCITG
AGTCGGCACG
TCTTTTGGAA
120 180 240 300 360 420 480 540 600 633 INFORMATION FOR SEQ ID NO:1041: SEQUENCE CHARACTERISTICS: LENGTH: 1056 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE: NO PGT!1S i nl~~ IPEMuS 18 DEC 1996 76S (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1 1056 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1041 A7AAGCAGTGG
GAAGCCCTAG
CAACGCCAT
CGTAACGCT
TTAGCGAATA
TGCATCGCCC
AGAGAAGCGA
GCCCTAAACC
TCTGTGAGCT
AAG7I7'A
ACOCATGCGT
TTTGGGTA
TTAGGAGCGA
AAAAACGCCT
TrGAATrGC
AAACCGGCGA
TGAAAGTCA
CAAGCGCATG
CTACGCCTCA
ACTTTAAGGA
ACCCCAAAAT
TGAAAGTAAT
TGGAAGCGCT
CTTACTGCC
TCAAACTCAT
AAGGGGGTT
ATATI'GAAGG
CGCCTI'ITI'
TCATTAAAGA
AGGCTCATAG
TTAAAGGGGG
CTTCTAAAGA
'ITGAAATGG
TTTAGAGAA
CTACAATGGA
TGAGCATGCG
CCACACCCCC
AGTCATTCTA
CAAGCTTGTA
TGATAGCACT
TAAAAGCTTG
11'GCTATGAC
TCAAACCCCG
TAAAGATGAA
CAGTAAGGAT
TAACCCAGCA
TAAGCCTATG
CGATGGCGAT
GGATATI'GGC
GC-rT'AAAA
AGCGACCATC
TTGAGCCAA
AAAAT'GGG
'ITATAAACAA
?1'ATGGCTCA
GTGIAGCG
AAAOGCGGGG
TACACGATCA
TTTAACCC
ACAGCGATCT
CAATI'AAGCC
AGCAGCGCGA
TTGCACAA.AC
AAGGACACI'
GTITTAGGGG
GCTTTIATGC
GAATGGTITCC
ATCGTGI'GG
TTTAGCGAAA
cIrTrGGI
TI'CATTGGCA
AAACTI'
GCGTGTAT(;A
AATrGGATI'A
CATCAAGGCA
CCAGCGATGT
TCCAACAAAC
ATrATAACGA
ACACCAAAAC
?TTACAAGC
TCACCACAAG
?ITATAGGCAT
GGGTr1GTT
ATGCGGTI'AT
CTGATAATGA
A'IITTCTCA
TCCCTAAAAT
TAGAAAAATC
AACAAGAAGG
AAGCTAAA
TGTTTATATT
AGAATCCGTIG
GGCTAGGT
GAGCCATTAT
GGCTAGAT
GCTCCAATCA
TITCCCTAAC
CGGCGATIrrA GGGTrZGAT
GGATCGAG
TGATGCGAT1'
CCCCAAATAC
AAGCATTGGG
CACTCCTTAC
TCAAATCAGC
GCTGI'AGTC
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1056 INFORMATION FOR SEQ ID NO:1042: SEQUENCE CHARACTERISTICS: LENGTH: 615 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: HeIlicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .615 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1042
TGCI'GGGGA
TCGCTCAAGC
TTTTGGGGG
ACCGCCCATT
AAAATGTATG
TAOACATCA
GGCAAGACCA
CTTTTAATT
TTCAAGCAAC
GCCC'ITGAAG
-,ATTTATAGGA
TGTGTTAT
CCCTCTCTAA
AATGv1I~AA
TCATAGAAGC
CGGATTTrGG
CTCAAGACGC
CTCTACCCTA
CCTATTTCAA
ATGGTATCAT
CCAI'AAAGG
CITTTr
TCTAAAGCCT
TGCGGT1-ITA
TAGCGACA.AA
GAGCTTAAAA
GTTIGCATT
CAACACTCTA
ACAAGATAGT
AGAAGAAACC
GGAAAACAAT
TITITGAGI'
AGGCTCTCTA
CAAAAATACT
AGCATIGGCGA
GGCATGGCGT
GGTAAGCCCA
TATGAAAAAT
CATGAAATCA
CTTAAAATCG
TTGATTTTAG
GTCTAAAATG
GGGGCGAGAT
GGCGTATTTT'
I'rCTrrITAAA
?I'CAAATCAT
ATTTAGCGA
TGAATCAGCA
TAGAATGGAC
CTCAAGTTI'A
AAAAACTAGC
GGCGAATCCA
TG3AAGACGTG
AGAAGACAAG
TAA.AGACGCC
TGATGATIG
?TTAAAGAG
TOAACAAGGG
TAAGGAAAAA
TTCTAAAAAG
GCAAGATGTC
120 180 240 300 360 420 480 540 600 615 PCTUS 9 6/ 0912a I PEAr' n I- '0 C 1 9 9 766 INFORMATION FOR SEQ ID NO:1043: SEQUENCE CHARACTERISTICS: LENGTH: 393 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc~feature LOCATION .393 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1043
AAGAAGGTAA
AGCTI'GAACG
GCCTA'fAAAA
GGGGTGAG"TG
ATAOAT'TATA
GGGTTTG
CAAGCCATflG
AOATGAATAT
CCCATI ATG
GCGGGAATA
AAGGCTGCAC
AAAAAGCCCT
GCTAGGGG
ACGCI'ACGC
CAAAAMI' A
GGGGAAACAA
TI'CTAAAGCG
GCAATTAGGA
AGAATATTAT
GCTTTATGAT
AAGGCATGCG
AAAATATTAG
GACAATAGCT
GCGTCI!ATI'
ATCATTTATG
AAAACCGCAT
GAGGGTTTIAG
TI-r TrIGGAGGGTI' 7TTAGGGAT TrAAAAAAGC
AAAACGGGCA
GCCAGGCTGA
GCACGGCTCA
ATTTTTG
TGGTGAAAGA
ATGCAACGAT
AGGCACTAGA
TGATAGGGAA
AAATTATCAA
INFORMATION FOR SEQ ID NO:1044: SEQUENCE CHARACTERISTICS: LENGTH: 717 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .717 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1044
TCCAOCAAAA
AAACGCCAAG
AGAAAC CC CG
AAAACTAAAC
AAAGCCACCT
ACGCTAGAGA
GGTCAGGTCA
CAGCATTCAG
AGCGGCTCGC
TAGGCTCTAT
CCATGT
TGCT171111 C
GCGATCTCAA
ATTTAGCGA
TCI'GTATAA
AAATTOAAGc
GGCAAAGCAA
TI'CTATGGG
CTCTCTI'TA
AGAATTGCAA.
TAAAGGCATI'
AGAAGCCCTA
TGAAGAAGGG
CGCCATTIGAT
GTCATTCAA
ATCATCACCG
AAAATTTCAG
GCTTCGGTGT
AAAGCTAT
CAAGCCAACC
AACTGCTACA
TTTrrGACT
GCGATI'GAAG
AATGAATTTA
CAACCGATAT
CGCATZTAGC
TATrAAAGCA
GGCGCGTAGA
GCACCAAGCA
CTrACTCTAA TrGAT'rrAAT
CCTTAGAAGA
TTGTCTI'rCAC
TAGCGCTCAA
CrATCAAATC
TGCGAACGAA.
AAGGATCATT
AAGTT CAAA
AGACATTGAT
GGGGATTGTG
GAGcGAACAA CATTAT T3AT ju 9 J~j q.
AATGGCAAGG AAGTGGAAAA TAAAAGCGCT TTATVTTAGC AAGGGGAAG GCTIAGGG'rr AGCCCTGTCT TTCAAGTCG AT*GCOCTAT TAGAAAIATCA AGAAAAAACC 1T1'GAAAI'A
CTTTTL-GAAAC
?I'AAAGCCCA
AGATTCTTAA
CACTAAAITA
TGAAGGGAGC
CGCTTCT
INFORMATION FOR SEQ ID NO:1045: SEQUENCE CHARACTERISTICS: LENGTH: 465 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc..feature LOCATION .465 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:l045
AAGCCTAAAA
TTGCAAGCGG
CCACCGAI'
ATGTTTGATG
TCCGAAGCGA
GACATCTTTA
TCTAACACCG
CC-AAGT~I'GC
CAAr'TTAAA
ATGCGATCGT
TTCAATGT
ATCTCGCTGA
TCAAACTCAC
AAGAAATCT
CCGAAAAAGA
AAAAATCCAT
AAAAGGACTT
GTTATTATIG
GCATAAAGCC
AAGGATCGT
TCGTGTTAAA
AGAGGACTAC
AGGCGATAAA
TTGGATGCTA
TTGATGAAAA
AAAGTGCATA
ACTGAAGAAA
CAATTAGGAC
GAAGAAACTA
AAACACCTAG
GTACCGTAA
GAAGCCCATI'
CAT7TGAAAT ACT1'CCATI'G
ITTATGAAGG
ACCACCCCCT
AAACGAGCTT
AAAAAGAATT
CTTATGCGGA
TAGCT
TTTAAAACAT
GAATGTGAAA
GTTGCGGAC
AGTCAC ITTA
CCACTCTAAA
TAAAGAGCTC
CGATCAATA
INFORMATION FOR SEQ ID NO:1046: Ci) SEQUENCE CHARACTERISTICS: LENGTH: 393 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: rnisc-..feature LOCATION 1. 393 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1046 GGAATT GCA TGCAAGAAAA ACGACTTAAA GCCATTCAAA ACAAAATCGC AAGGAAAT G AAAGCGGCTT TATAGATOCA TTGITTI'CTA AGATTGGCCC ,\TG.CGCTCCA AACTCATGCT CGC'ITrGTTA GACGAAAAAA CAG.ACGCTAT ?*GCGCTCA A'ZTIIGTGTGC GATI'GTGGAA ATZATACAGA CCGCTTCTTTI TTCT1'GGATC
TICAAAGATG
ITTATrAGAT
ATTGCATGAT
120 180 240 POUS 96 0912 i PENi1S 18 8OEC'99 6 GATTGAT ACAAGCAC CATCCGCCGA AAGCTCCCTA CCATTAACGC TCTITGGG AATTTTAACG CCGTGATGCT TGGGGATGTG ITrFATTCTA AACC TTT TGAG'TTGTCT AAATGCccc AATCCATCGC TCA.AGCCCCT CTC 9 6 INFORMATION FOR SEQ I0 NO:l047: lPEA/S 1 8OE SEQUENCE CHARACTERISTICS: LENGTH: 1731 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genornic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1 .1731 (xi) SEQUENCE DESCRIPTION: SEQ I0 NO:1047 300 360 393 rG91. 2.
C01996 TO CATGCTAT '1FAAAAAG CC
TATAATTTCC
COCATOCAAG
TCGGAAAAAT
AAGACAATG
AArI'TCATCA
COTGATGAAA
GGTTATAGCT
CCATAAAG
GGGGCGATTG
ACGATCGTGG
AAAAGAACTG
ACCAGCGCTC
CTI'GTTAACA
GATGACAA1'
TTAGAATI'AA
ATAGGGCCT'
GAGGGCGATT
TTAAAGGGT
TGCCCTAATT
AAACTCOGGC
GAGCGGTTT'
TTAGAGCAAA
GTGGTGATCG
TATGAAAGAC
GGGGCGAAGA.
CAAACTAG
ATCAAAGACA
TTTCAAAACT
CTAAGCACCC
TACCCTTAGC
AGCATGGGGC
CAGGCCGT
ATTTGTTTT
AAAGCTACAA
TCCGCCCAAG
TTCATGAAGA
AGATTTTAAG
GGGGGAGTAA
TGTGTCAAAA
AGCCTAAT
CAAGCGTGGC
AAGTGATCCA
TAGAAGAGAC
GAGAGGCCAA
ATGGCTTGA.A
GCTTCATCGT
TTAAAACCT
GTCAAGGAGC
AAAGCTATGC
TTGAAATGGG
AAAGCGATGA
TGGTI'rCTAA
TGCTCCAAAA
TGAGGGATTT
AGAGTAAGGA
TAGAATrAGA
TTTTIGCCCCA
CGGGAACGGG
TAAAAAAGTG
GCAAAATATT
GGATAAATAC
AAGTCCCACT
GCAATTACCC
ATTCGGGTTG
CGCTGAAAGC
CGATGGGT
AAGCAGGGAA.
?TTCGATTAT
GTCCCCAAGC
GGAGTTTT
TAAAGATAAA
TAAAGCCCTA
TGAAGAAGAT
AAAGCATGTT
TGGGGCTAAT
TGITTATGCG
GTTOAAATAC
TAAAAGC7I'G
GTGCTATGGG
TCTAGGCTGT
CCTGAAAGAT
GGGCGTTGAT
TGAATTGATT
AITTTGAATGC
AGAAAAAATT
ACGCTCAAAG
GGACACCCCC
CTAGACAAAA
TTAATGAGTT
GGCAAGGAAT
TTAGAAGAAA
GTGCATCTCT
GTGAGAGCGA
I"IGGATAAGG
TTGGATIC
TTTGTCGITTT
GCCCCAATA
GCATI!AGCGA
AAAACAGAGC
GAAACCCTAG
AACACTGA
TTAAATAAAG
TGTTATATTA
GAAAAGGATT
GATATTGTCC
CATAAGAGT'
AAGGCTAGT'
ATAGGCATTA
GTGTGGACGA
GAAGCGCAAA
GCGCTGTTAG,
GGGGAACGAT
ATCAAACGCG
TI'AGAAATGT
AACCCCCAAA
TICAAATAGG
TAGAAAACGT
TTGTGGITTTT
TATTGGTTTT
ATATCACCCA.
ATCAAATCCA
GGGAATAT
AAATIAAA
GCATTGTGGA.
TAACAGAATG
TTGAAA.TCGC
AAT1'CCCCAC CTTAI'1TIGT CGTGCTITI'r ATCTI GGG
CAGGGTTAAT
TTTTGATGA.
TTCATGCGG;T
AGGTTAAAGA
TGGAAGTGGG,
TCTTGGA.TAA
GCCGGTTaCT
AAAATACCGC
AAAAACTCGC
ATGACAGAGA
TAGCCTTGAT
CTAATTTAGA
TAGCGAGCGA
AGACGCCGTG
CAGTGGGATT
CACGCACAAA
GGCGAGTI'G
TAAAGACCOA
AAIGCCGCT
CACGAAATTC
CATCAAAGAT
CACGCAAAGC
AGCGGATAGC
CGGGGAAGAC
TAAACGCTCT
CCCTAATACC
CTrAAAAGCG 7TTAGGGGC
GGCGAACGCT
AGCGGGCITTT
AGATrAAAA
GGGCGTGGAT
GACATIT
GCATATI'1TC
GAATGGCAA.A
CAGCGTGATT
TCCITTTTGAT
?ITT GAAGTG CGCTCGTI'r TOI'rGGGAAG
AAAGCAAACG
120 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1140 1200 1260 1320 1380 1440 1500 1560 1620 1680 1731 INFORMATION FOR SEQ I0 NO:1048: SEQUENCE CHARACTERISTICS: LENGTH: 552 base pairs N) STRANDEDNESS: double POUS 9 6/ 0912a7 IPEMJS 18 DEC 1996 769 TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc...feature LOCATION .552 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:l048
ATTCGTGAGC
ACCAC'TTL=
AAAGCGCGCC
AAAGAAGAAC
AAAAAGATAG
ATCAACCTTG
GGCGCGCTCA
ATTTTIGCG
GACACTAAAC
CACAGGTTC
TCTI'CCCT
AAGACACTGG
GATTGGAC IT
AGCCTAGAGA
AAACTA.AAGG
TCATGCTGCA
TGTITTATT
GCATCTTAT
AATAATGACT
GGCGCI'CTT
CGCTAAGATC
TTTAAAAGGC
GTATAGGGGA
CACTCAAACG
TAAGGCTAAG
GTTGTTAC
AAGCG~rI'I'A GCAATGAT GC TT GCGGI'A
AAAGA.ATGGG
TTTATAAAAG
GCGTI'AGTCA
AAAATCAAGA
GTGGGCATCG
?I'GAGCGCGT
ATAGGGAGCG
GTTATTTTCA
GTGGGCTTTC
TITTAGAAAA
AAAACCATAT
T GGCACGCC
CCATIGAAAG
TGTTTCAGGC
TTI-rAATGGT
TGGTGTTCTI'
CATCTATGCG
ATTGCTC'Tr
ATCCTTAAAA
CGCTATGCCT
T
0
ITGTATGAA
GGGCTI'ITTA
GCITIAGGG
GGCTTTTAAA
TGGAGCGATC
120 180 240 300 360 420 480 540 552 TATGTCTT TG INFORMATION FOR SEQ I0 NO:1049: SEQUENCE CHARACTERISTICS: LENGTH: 270 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .270 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1049
CTAATAAAAA
TTTGAAGCTT
AT ATCAAG T'r1I I GCTL'
TTTT~CTAAAT
GCAAATCAAA
CCATGCAATC
AGTTACGA
ATGAATCTG
TCGTGAGCCA
AAAGTGGCTT ?TGGTAGGGG GCI'flAAAA ACGGATGGCG ACTCA.ATTCG CATAAC GGG T CGCGI'AGGG T'rTAGAAAAG
CAGGTIGCAA
AAGGGGCGAA
TTTATTCTAA
TGTATTATCA
GGGGGTTAAT
TAGTGAAATC
CCACAAACCT
GCCTAATGTG
'ITTGGATAAT
120 180 240 270 INFORMATION FOR SEQ ID NO:l0S0: SEQUENCE CHARACTERISTICS: LENGTH: 849 base pairs TYPE: nucleic acid STRANDEDNESS: double AIJ_2.,OD SHEET POUS 9 6/ 0912 :iEAAuS 18DEUi199 770 TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misctfeature LOCATION .849 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1OSO
ATOCTAGAGA
GCCGTGATGA
CACATITCTT
rTAAATGCGG
TCTAGTAACT
TATGATTTGT
GCTATCCAAG
GATCCCAAAA
TTAGTGCAAG
TCAGGCACGA
GACATCACGC
GACAATAACA
ACCATTGCCG
TCAATCTTGC
AAACAACAA
GCGTGAACGT
TTACAGCCTC
CTATTGGCGA
TAGATGGGAA
TGCTCTCAGC
TCCATAAAAA
TGCAAAACAC
CCATrCAAAT
AAATCCCCAT
TCGTCAGG
TTAAAATCAC
TGTCCTTAGA
GGGTCGTAAA
AAGCCCTAAA
TAAATCT
CTTGCCCCCC
TGCGAAATCC
TATI'TACGCC
CAATATCATC
CGCCATGACT
'TrTAAATAAG,
CACCCCCCA
TTACTACCGC
AGTGGATATA
TAAAGAGCCT
CACCGCTCAC
AGCCI'ACAA
AAAAAGCGGC
GCAGACGATA
'ITTGCAAGAC
ATTCAAGGAG
CTCGCTCAAG
AACGGGGCGA
TAAGCCTGA
GTATTGGTA
GAGCGTCTII'
GCGAAAAATA
ATCGTGCATC
TTAAATGA?1'
AACACGCTGA
AAAATTGGCG
GCGATTAGCG
TT~AAATCTAA
AGGGCGATAA
GGACTTTAGT
GGGCTATCAT
CTATI'GAAAG
AAAACCCCAA
ATAAAGTAGC
CTATGGTCGA
AGATCATITGT
CTATAGTGGT
CTAAAAACAT
GTICTAACGG
TGAGCGCTAA
CGAAATGGAG
AAATGTCGCT
AATTGATAT'r
GATGACCCCT
TTCGGGTAAT
GGAAGTI1TCG
'TITTAAAAAC
CATAGCGCTA
GTI'ITTAGCT
AGATGAAAAA
TACAAGCCAA
GCAGGA'TTA
GAAAAACATC
GGGGATGGTr
ATACTATCAT
120 180 240 300 360 420 480 540 600 660 720 780 840 849 INFORMATION FOR SEQ ID NO:1051: SEQUENCE CHARACTERISTICS: LENGTH: 666 base pairs TYPE: nucleic acid STRANEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .666 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1051
ACGGGACATG
AAACAAGCCT
G TCAATAC
TTAGAAATCC
CAGGAGCAAA
ATTTTGTAT
kTTAATGCAAA
GCAGGTTAGG
GGATTLTATGA
GCCTTCTAAC
AAACTT =T
TTGACGCT
TAGGCTATAA
ACATGAGCT
AAATGATCAA
GTGGATATI'A
GCGCATGCTA
AGCCTGTA
GGCTAAATAC
AGATTCTCAA
CAACGCTAAC
GGGTTTGTCT
T'rTAGAAAAA
AATCCAAPLGA
TCTTTTATAA
CTGC ITI'A
CTTTCTAAAA
GAAAAAGTCG
GTGAGCGATI
CAAAAAGTGG
CAAAAAAAAA
AGGCCAAGTT
GCGCGTTTGA
GTTTGGGTI1'
ATCAAAAAAT
TTAGCAAATG
TTTTCAGGCT
kTAAATC4
TATTAGAGCT
TATCGCACTA
TAAAAGGGC
GGCTAAAGAT
ACAAGCCCTA
GGATAACCCT
GGATAGCACC
TAAAAAACTC
TAAAAAALACC
120 180 240 300 360 420 480 Ufl~WC~? ~PEMJS18 DEC1996 AAOCAGCAAT T.:GGL-;A'rAA T-rrAATCATA AACGGCAT AAAACTATPA GAAATAGAGC TTTTAAACAC AGCGATTAAA AATTAGAAA ACACCCTCTA CATT'CCAGTT CGCCCGA'T 1' AATAGCOATC GCCAAGTrAG AAATTAA
GAAATC
INFORMATION FOR SEQ ID NO:1052: SEQUENCE CHARACTERISTICS: LENGTH: 1041 base pairs TYPE: nucleic acid STR.ANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .1041 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1052 AA.AccAACAA
TCAAGCCAAC
ATCGCAAT'A
ATTG'L-r-ITTC
TTAAAAAGA
TCTCTTAG
GCGTATTTCC
CCTACGGACT
CAT1GCGCTCA
ACCCCCCCAA
AGOCTGGTTT
OTTCrTATTG
GTGGGCAAA.
ATTTCTAGCG
TGGATGGGGC!
ACCAAAGCCG
CCCAACGCI'
AC TTAGTGT
GAAI'GGTCA
GTAGCCATI'A
7ITCAACGCTA
ATCAAGGGAG
ATAAGCGGGC
CCCCCTTOTG
CTATGTWI'AA
ATAACGATCC
TCCCI'ATAG
GC ZTCAAACA
ATGGCTATCG
GCGTGAGTTT1
GGTI'GAGCGA
CGTTCAAT'C
?ITTCTCAAGT
CTAGAGCGCT
TAGTGGCAAC
CTTIrGGATI'r
ATCAAGGCAA
GCTTGTI'GCT
ACATGCTCAA
'ITTGAGCGTC
GGTGI~T1CA
GGTCAATGAT
AAACTATGCG
TATGTGCAA
CTACOATACG
CCTTAGGC
GGTTTCGTTA
GGGGGCG TI'
AATTTGGAGC
TAATTTGG
CGTGCGCACG
TGGGGTGAAT
GATCACTTAC
CTrAGGTTT
GGATAACCTC
TI'CTGTrTG
AGCGGTTTGT
CTCTATCTI'I
CGCCCTTrAT
OAAGTGGAGT
AACACGC'Tr
ATCATTATGG
ACAGACGATC
GTGTII'GGGA
CAGGGGTATI'
GCGATCCCCA
ATCATCTrrGT GAGrTTrAA
GATITAAAAA
ATTrCCTIT
GGCATGCCTA
ACCACGCCTC
GTGTICATIG
TAAAATGCG
?I'ATCGCTT'
TCATCTATAA
'I GGAGGCGA
TAAAAGACGC
ATTTAGACTC
AAGCCAGAGA
TTTI'ACTCAC
ATGGAGGGCT
TGCIT1TI=
TTTTAGTCTT
AAGCAAGGAA
TCATITCTA
TAATGGCGGC
TAGGGAGCGC
ATTAGCGGT
GCGAAGGGGT
TATI'CTGAGT
GI'AGCGCT'r
AGACAATAAA
TITTICACC
TTCATCATC
GCCTGCCCCC
CGTG3T1AGCC
CCTTTTTTAGC
AGTGGATI'rA ACTCAT1TGTG
GCTCTI'TAGC
TATGGACTAC
CCATGTTTI'A
TAGTA'rTTCC
GAGCTGGGC
TGTAGCCTI'
GCGCGATGCT
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1041 INFORMATION FOR SEQ ID NO:1053: SEQUENCE CHARACTERISTICS: LENGTH: 1557 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No ORIGINAL SOURCE: ORGANISM: Helicobacter pylori A% ~i~flSHFFr.
POT/U S 9 IPEMUS i 6/09 1 a b E U ';J496 (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1557 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1053
AGGGGTTACA
CAAAACATCA
AGCGGGAAAA
AATGGCGAAA
CATTAAGGG
TI'GCATAAAA
CAAGTCGCTCC
T'TvrrrGGATC
ATGOGCATI!A
GCGCAAATCC
GCCCTZ'AT
GTGTrAAAAA
AAGCACGAAT
GCGCTAGATC
TTCTTTAGGC
AAAGAAAACA
CIT=AAAAC
TTAAATCTA
TACGCATCAT
GCI'ACCCTA
GTGTGT=AA
CAAAGAGTGG
CCAACCTCTG
CAAGAAAAGC
TTTGCGATA
GAGGTG=G
TGCTAGAAAT
ATA~TTC?11'
GCTCTATCGC
TCCTGTrGA
GGAATATTAT
TCGGCAAGCA
TAAAGAACA
GTI'ACCCTTA
TTAACGCGCC
AAAACCAGAT
TCATTAGCCA
AAGGCGAGAT
AT CAAAACT AGACGC TIT CTTCTTT1AAA
TCGOCATCAT
TCGCTTTAAA
AG3GCGTTCAA.
TAXACCCTCG
AAGCTTCACA
ACCCTGAAT
CCATCGCTAG
CTTTAGACAA
AGATTAG
GGGTGTrAGT
ACAACCCCAA
CAAGAATTTA
AAGTTATAGT
TAATCTCGTC
AACAACCAAT
CGCTTACATC
AATGAGTOAPL
AG=IIAAAC
TG;AGCTCAGC
AAAACTG3CTC ?'rAGACTTG
TGATT'AAAG
AGTAGAXACC
C ITGATTCAG
AGAGGTGAAA
AAAACCCCTT
TrGGCGAAAC
CAGCGGGGAA
ACCCTACCGC
CTTAAGCATT
ACAAGAATGG
GCTTAACTT
AGCGATTGCC
AAGCATTCAA
CTATrrG'ITr
GGTGAGTGAG
ACACGCTTAT
AACTGcGTrT
GAAAGGGTGG
ATGCGATTAA
CTTTTAAAGG
GCCCAAGACC
GCCTATI'TI
GCCATGAAAC
GGTGGGCAAC
AT='CGATIG
CTCAAGCAAT
GCGGTI'AAAC
AATTTGACTA
GC71'CAAACT
GATTIAGCG
ATCOCATCGG
GWGCCGA
GAAAAOATTI'
AAGATTTTGC
CAAAGCATI'I
CACCATITAG
TACGCTTATG
TrAAAACCTA
AAAAGCGTGT
ATCAGCCATG
GGGAAAATCG
ACCAAGCGI'
TAAACTCTCA
COATCGTGGG
ACCCTAGATT
AAAGCGAAGC
CCCTATCCAG
TACACCATAA
AAGTCCAATT
GCCAAAGGGT
AGCCTACCAC
TGAGCGTGGA
GATTIGGCTGA
AAGAGCTT
TOCCCGCTAA
TTTAT'rACTr TGGA?1W1?1C
AAAGCTCTCT
TAGGCCAAAG
AAATGGTGTT
TAATAGAAGC
CTGA.ACTI'r 4
AGCTCAGCGQ
GAATCATTCT
TGGAATTATT
ATTTAGATGT
TGGAAACAGG
TGTP7GAATC TTrTCGCTC
CGAAAGCGGG
CAAGCCCCAT
GTTCATGCAG
CCTAAACCCC
AAACGCTTCT
GGATGCAAAAA
GTGTATCGCT
CGCGCTAGAT
AAAAAACATC
TAGGGTTTAT
TAATGACCCC
A~ATAAA
GCAAAAACGC
CCTCAAAGCT
AGCGTTAGGG
CGTGGGGCT'
TCAAGACCCC
?rrGcGCTl'
C'ITAGAAGAA
AGGGGACCC
TTTAGATOAG
GTTAAT'rA
GATCAAAGCT
CGCTATTGAA
CAGGCTT
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1140 1200 1260 1320 1380 1440 1500 1557 INFORMATION FOR SEQ 1D NO:10S4: SEQUENCE CHARACTERISTICS: LENGTH: 549 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-.feature LOCATION .549 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1054
GGGGGACTA
ACTCTAGCGC
AGCCATAAGA
T TTTTACCCT
GAAAAAAGCG
TGAATACTAT
AAACCCCCTC
A'TrAAAGCT
CCCCTAAAGA
ATAAAGCCGC
AAGCGCAAGA
?TI'GCCTAC
TATAAGATAT
TAAAACCCCT
CATTGATCCG
AACAGCGACC
TTTGGGGCTI'
ACTCAGTGTC
=ZGAACGCG
GCGAGTTTAT
GATGAAATCA
CCGACAAGTT
ACGATCAATC
TATGAATC
AAGCAAGCGA
AGTTATAATI'
GGGGCT IGTG
AGCAAATCCT
CTTTAGAAGC
AAGAGATCGC
TAAAGGGGGC
TGAAGAACCA
?I!AAAAATG3A
TAITACTCTA
TAACAATI'AT
GACACCGGGT
TAAATACCAT
TACCACCAAT
CACCATCGCC
AGCTAGGGAT
I 4 e" i t- c.t- rl-r IWS I J DEC 1996 ACTCCAGAAT ALTAAGCATA TAACACCCAA CAACTCCAAG CTCAAGTCAC TTTAATGGCT TTAGCAATOT GAATAATGSTC. AAAGAAAAGT CTGCGACTAC
TCCCTAAT
INFORMATION FOR SEQ ID NO:1055: SEQUENCE CHARACTERISTICS: LENGTH. 687 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .687 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1055
ATTGAATGTG
CGATCCACTG
GTGAAATTCA
ATITT'AAAAA
T =AGCGCTA AT TT'AGACC
AT'ITAA
AAAAAGCATG
?I'GGGTOCTG
GCGTT7GTGCT
TCTTTAGAAA
GTI=AAAT
CATCCTAAAA
CTTGATTTAT
GCGTTTTAAC
GAGCG TTAGA
ACAAATATCA
CTGAGATGAT
GCGCGGTCG
TCGTTTGGT
ATGAGG 1*11
TGATAGATAG
ATGAGAGT
CCAAAGAAAT
TCAAGCAACT
TCAAACAGCA
CCTTTTCCCG
AAAAAACCI'
AA.AAGCGOAT
AGAAAACGCA
CAAGCCTTTC
GTGCGGGCGT
TrrGTATAGGC
TATCGCTCGC
TCGAAA.ATAAT
CAATAAAATC
AAAGCTTGAT
CAAATCA
CAACTCATCT
TTrGAM-TGG
CACACGCTCA
CTCCACTCTG
AAGCAAATAG
TATOAGGGCT
GATIITIAT
CACAITCAAG
TATTTGGAGA
CCTGCACCT'
TTGTCAAAAT
TGCCI'ATrI' A6AGTGTTAAA
TTGTGGGGG
TTAAAA6ACCC
ACGCOATGCG
7M~ATGAACG
TAACAGGGGG
GGGI!I GGG
CCCCTAATTI'
TAGAATATTC
TAAGGACAAA
TGAAGATI'CT
CCTI'AGAGAT
TGCGGGGCA.A
TAAACACACG
ITTTGGCTCAA
CTCTATI'GAA
CGAGCTICGG
TAACGCCCAA
CCCTAACGCT
TAAAGGAAAT
A'T'ACCGC
INFORMATION FOR SEQ ID NO:1056: SEQUENCE CHARACTERISTICS: LENGTH: 1.098 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .1098 SEQUENCE DESCRIPTION: SEQ ID NO:2.056 i-LINDED SHEFT POUS 96/0912.2 IPEN1JS 180DEC 1996 AGGACCAGT .GG~rrCACT
CAAGGGAOCG
AAAAAAGTGOC
GTITT7GGCG
ATCGCCAACA
AGCGCGGGGC
GTCTTAAATC
AAAAGTGCGA
GATAGCGAT
CG TITTATTG
GTGGGGCGI'
TTAAACCCTA
AACGATT
TCTATCATrC
TCTII'AGAAG
AACCCCGAGA
GTGTCTGAAA
CTCACGAATA
GGAAGACAAC
TITI'ATGCGC
AACAGGTGG
ACGCTITTAAA
GTTTAGCGAT
CCCATCAAGT
ACACCTAA
CTAAAGGGGG
GGAGTGGGGA
TGATGGGGGC
ATGAAGCCAAP
TAAACCAAAT
CAGGTTTAGG
TGAAAAAAAT
TT TTAAACGG
TCAATCGCAT
AAAAGGGTAT
TCGCTCA-ACG
CACCACCGCT
ATGCGATITG
CGTGOAAGTT
AAGGGCTAAA
TGATAAAGAG
GCTGTATGTC
TGAAGA.ATA
TATCGCCT'A
AAAAATCCCT
TGGAGATATT
AGATTTAAGC
TGAAAAAGTG
GAATATGGCA
CAAGGCCATIG
CAGCCGAAGA
CATCAAACC
TAOCGAT'I G
CCCCCCACCG
AAACTCGCCC
CAACGCTrAG
ITICATGAAG
GAAGCGCAAT
CTTATGCAAG
GCAGACGCGT
GGCGTCAGCG
GGCATCACTr GA'TrAGACG
ATCTCGCTCG
AAAAAGCTCA
AAAAAATTAG
AGCGCGCTAA
GTTAATTCCA
AAAAGGATCG
TTTATCAGG
ATGAATCTAA
TGGTl'TTAAT
ACTATCTCAA
CAGCGGTGGA
AAAATAAAAG
TTr3ACGTGTT
AATTAAAGGA
TGAGCGGGCA
GGGTGGTGTT
ATCAATrG TGT7rATGCC
CTGAAAAAAC
AAAAAGGGCA
GCTCTATIGAG
AAGACACGGA
TGACGAAAAA
CTrAGGGAG
CGAGCAAAAT
TGAGTCAGGC
GGCAGGTTTrG
AACCAAAAAT
GCAATTAAAG
COTGAA.AGAA
AATCGTGGAT
AG~TTAA)LGAA
AGATG.GGGTC
AAGCAAATT
CTTACCCTrG
TGAAAGGATT
CGCCAGCGTr
TCTCTGATC
ITrTAGAAAGT
AGAGCGAGAL
CGGCTrAGAA
GGCGAAACGA
TAAAAATCAA
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1098 ACCCCCCCTA AAATGCGC INFORMATION FOR SEQ I0 NO:1057: SEQUENCE CHARACTERISTICS: LENGTH: 810 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc..feature LOCATION .810 (xi) SEQUENCE DESCRIPTION: SEQ 1D NO:l057
AGGAAAGCGA
A'rTGACTCI'r
GATAAAGA.G
?I'ACAGGT'TT
CAAAAGAAAA
GATATTGCTA
ATCAAGCACA
TTAGCGTTCG
CAGATCATCT
TT TTATGAAA
GCTTGTGGGO
GGGACATGA
AGTAACGCTC
GAAAGCCAAG
TGAACACCCA
TAGAGCCGTT
CTAAAAATAA
CTAAAAACGA
TGAGCGAGAT
AAGAGCGATC
AAAGCGAAAA
AATGGA
?I'AAAAAGAA
GGATT~AGGAG
GTTGTTTTAT
TCACTTCC
AACCTCCAAA
AAGAAAGCCA
CCTCAAACAA
GATCAGAGAA
ACATI=r
GCAAACCCTA
CAAATCCGAA
CAATCAAGCC
ACAAGAAGTT
'TTAGTGGAA
AGAAGAACTC
GTrGGGCGAAA TCGG'rrGAAC
GTATTGCGGG
AGAAAGCCAA
AGAATCCG7'
TTGATTGAAA
AAACGGAAAG
AA TOOAAG
CAAGACACOA
AGGGAGTTGC
AACAGAGAAA
TTGAAAAAGG
AACGAAGTCA
GTGGAAAAAA
AACACGAGCA
GATAAGATIr
CGTATITAT
CCAAAAGAAA
'TICGCAC?1'
ACTTGGATAA
AAGAAAAATT
ACGCTAAAAT
GCTC?1'TAAA
TTIGAAAACCT
AAATGCTAGA
AAAACATCAA
CCGAGCCTAA.
TCGTAACGAT
ATGCCGAAGT
ACGCTOAGAG
GCCAAGAAGA
CGATAAAGAA
AGCCTTGAAT
AGCCCTAAAA
CGCCAGTATC
CATTGAAGAA
GCAA.AATGAA
GCTTGOAAAAA
AGAAACCCAA
AATCTATAGC
CAAAAAACAG
GCTAACGAGT
TACCCATOAA
AAGCCAAGAA
120 180 240 300 360 420 480 540 600 660 720 780 810 INFORMATION FOR SEQ ID NO:10S8: SEQUENCE CHARACTERISTICS: LENGTH: 1701 base pairs 11 1tN7(B) TYPE: nucleic acid PCTIUS 96/0912 2 7S I PEAAJS 18 E C 1996 CC) STRANoDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FE.ATURE: NAME/KEY: misc...feature LOCATION .1701 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:10S8
ATGAACCAAA
AAAGTTAAAA
AAITTGAAA
GGTGAGCCT
GATGAGGCGA
ATGA.AACCA
AAAATCACTG
GrTTCAGCCC
GTGGTAAAGA
AAGCAGGTGC
GGCATGTCT
GAGTATAAAA
AACGCT TTTG
TTTAA.ACTCG
GGGGCGGTA
CCGATTGAT
CGTTTTAAAG
AT1'1TTCATG
CCAGTATC
CATCATGAGG
GACCCTAAGG
,TTCGCCCC
TACATGGTGC
GCCTTACTCA
GTAATACCTC
CGCATCCAAA
TCOACrrrrr1
GAAGAAAAAT
GAAAATTTIGG
TTGACAAATC
CCCCAAAGGG
ACGCCCTAAA
ATATTGTCCA
TGGTGTGCGC
TTGAGCGAGA
AAATCAGGAA
TCACT'TTAG
TTAGCGACAG
GTATCTAA
CAATCAAAAA
ATATTAAGGA
CGAGCAAG'T
TTACAAGGGT
ATATTGATGA
GCTACAAGGT
ATTACATCGC
AATCTTCTGT
GTAATTCAGC
GCATGCOOTG
AkTTACGA
ATGGGGACAC
ATAGTGATT'
ATCAAGAATI'
GTTTCATTTIG
GAAGAAACCG
TTGGGCGCTC
TAACAGATTG
GCCAAACTCA
CGTTGATATC
TGGTATTGAG
TTTAGCGACC
TCCTAII'GC
CGCGCTTTO
ATTT'GGGCAA
AGAAGAGTTA
AAAGATCCTT
GTTGCACAAC
AGAAACTCTA
CGAATTAGAA
GTAmTGCAC
AGAAAAAAAG
GAAACGCCCT
AATTI=rGAC
TTTAGGGAT'
TTTGCCCAAA
TTATGAAGTG
CCATGGAAG
GTTGCAAAAT
ACTCGCTAAG
TTACACTTTA
GGQCGATAAA
AAGGAGTGGG
GATGGATCAG
CTTGAXAGAA
TGwlw=AA TGvGGGT GGAG
GGATTCTTAC
GTTTTAAGGA
AAAAGCCATA
GTGGCGAGCG
CATGATGTGG
GATGTGGCTA
GGCGTGAG1'
ATTAGCGCGA
ATGCTCACCT
GCGGTGTATG
GACAAGAGCT
AAAAACAXAC
CTITTTGACA
TATI'CTATT
TTGTTAGCCA
ATTCATTTIGA
GAAAATOGCT
CAGATCCGCA
TATAAAGCCG
TTTAAATACC
AACGATI'GT
CCGGTGGGCG
GCCACGGACG
GATGTGGTA
C1'rAAAACT' AT'rGACACTA
GATGCGGAT
ACCACCTTAA
GGATICTGGA
CTTTAATTGA
AGGGGCAATA
TGGTGGCG'T
TAGAAGACAC
ATTTAGTGGA
CTCAAGATCC
TACAAGATCC
TAGACGCCT'
CCCCCATAGC
TTTATTATAT
AGTCTITrACT
GCGGGTTTAG
ATCTI'AAGAT
TTAGGATTTT
AT'TTCAAACC
ATAAGACAAT
CTTTTrGATAT
GGCGTGGA
ATCACAGCGA
ATCGTGAAGA
CGATCGCITTT
CTTATATCAA
AAATCATI!AA
CTAAGGCTAA
AGAGCATGAT
TGAAAGATTA
CAGAPLOCGAT
TGTI'AIAAA
?ITCACGCCC
CAGAAAGAGC
TTGTGGGGGC
GCCTTGTGAG
TCCGCTCACC
CAGAATGGTG
AAGAGCCTTA
GCCTCATGAC
GAGTCGNI'IG
TTATCCAGAA
CI'AAAACTC
CCATI'CGGAT
CCAACGAAAA
ATTGAAAAAC
CATrGTTTCT
ACACACGACG
OCACATOGO
TCATGAAGAA
TTTGAAAAAC
TAT TGTCG?1'
AGATTTCGCT
TAGTAAAAAA
AGGCGATAAA
AACCATTTG
CAATATCTTA
TAAAAACI'r
GAAAAGCTEIT
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1140 1200 1260 1320 1380 1440 1500 1560 1620 1680 1701 INFORMATION FOR SEQ ID 10:1059: SEQUENCE CHARACTERISTICS: LENGTH: 594 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni AmPgflcn cuccr 6 0 CO I96 TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAmE/KEY: misc~feature LOCATION .462 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1061
ACATTACTA
GCCCTTATCC
GAACTAGTGA
GAAGTGGGGT
ATGGTGTTAA
TTAGCGAATI'
GTGGTI'CAAA
AGGGGTAGCG
TAAAGAGATI'
CTAAATACCA
TCAAACCTCA
ATGAACTGCA
ATICCCCTGG
TGAGCGATAA
AAACTTATAA
GGGGGtTITGG
TGTTGATG
AACCGAAGGC
TAGCGTGGGA
GGTACGCACC
CACGGTGGAT
AGATTT'AA
AGCCCAAT
CAGCACAGGA
AAAATTrAAAA TCTrCAGGCT
TIGGTAAGGA
CGTAGCGGCT
AATGAT1'ATA
GTICAAGTAG
ATAGAATGCG
GTGAGTAAGG
TCCAAAAAAT
TTGATITGCA
7?IGGGATTTG
TGGCTTTTGAA
GGGGCGAAAT
GGGATAGGAT
AACAATTAGA
CA
CCACCCAAAC
CGCTGTAGAA
TTTGTC~TTA
TCATCAGGTG
TAAGGTCAT'
CGCTCAAGGG
TGAAACTT CA 120 180 240 300 360 420 462 INFORMATION FOR SEQ ID NO:1062: SEQUENCE CHARACTERISTICS: LENGTH: 525 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc-.feature LOCATION .525 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1062
AGAAAGAAAC
ATAGCCCTAA
CAAATTAAAG
CGTTATGGAG
AGAAT GGTA ATCCTflGCAC
AAGACTGAAG
TGTCATCAAG
CCTTTGGAGA
CAI'CAAGGA
TI'GCCTTrAG
GCGAAGCGTA
CCAITIWIGAA
AGAArrl'CAA AAGA'I GTT
AAACGGAAI'
TGGAATTGAT
CTT TTGCCTT ACGCATTrGAT
CGGCTGTAAC
=tICCCTAAC
AAATCGAGCG
TTATCGAAAGC
GAACAAGATI'
GAAATTAAAG
TAGCAATAAC
GGCGCGAGCG
TTGATGAATA
ATCAGAAAAT
CATT GCAAG
GTTATAGGCG
AG'TTrTAA
GATAAAAAAA
GGCGTTGAAG
CCTAACGCCA
TTAAGGGA
AACCATTT
ACTLTCAAACC
AAAGCATCGT
ATAXAGGTT
ATGAGAGTCA
CAAGCAAAAG
CGGAAGTCCA
GCCAACAATC
TCTT
AATCTTACTC
CGCTAAACAC
TrCGTCTAAT
AACGCAGCTA
AGGGT1IrX
CAGGGCGGCT
AGATAAAGTC
TATCGI'ATT
a POTUs, 'O1 I PEAIUS 16O u c. i 779 SEQUENCE CHARACTERISTICS: LENGTH: 657 base pairs TYPE: nucleic acid STP.ANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc...eature LOCATION I1.. .657 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1063
GGCATGAGCA
CT=3.AGAAG
TTTATCGTGG
GAGCAAACGA
ATAGCCTGC
GCCAGAGCGA
OZkAATCGT A
CTTGAAAAAA
GAAAAATT
AOTTCTTCAC
C AG CAAAAC C
TTAAGGAA.
GAGCGTTTAG
TGGCTTTTAT
GAGAGCGGAT
AAAAAAGAI'I
GTGAGAGGAA
AAGCGTTCGC
GCCCCATTCT
CTAAAGACGC
TCTATGCTAT
CTTCCAAACC
TTTAGAGCAA
ATTAGAAAAG
CGCTTATTTA
CACTCAAATI'
GAAAGAAGTC
CGATGCAAAC
CAAATATI'CT
TA.AAGAAATC
AATCAAAAAA
AATCTCTGTT
AACCAATCTA
GTAGAAACG
TTI'1TCAAAC
GGGGATACAA
TATAATGAAG
GCCCCAGAGT
GAGTTTAAAA
TACGCATCGC
AGCGCTTAC
GCGCATCAAA
TrAAAACA'rr
AAGAAAGAAA
AATTTAAAAG
GCTACAAGTG
AATTACAAGA
TOCTAGAGAG
TGTATGACT
GGCTTTCGCA
TCTCTAGAGA
AAGAAGTGAA
GT'rTATCAAC
ATGGAATG'L'I
CCATTCAAGG
CGATGAAAAG
GGTGTTG LTG
TTATAAGCAT
TCCTAATAAT
GTATCAGT'C
ATCTTCTAAT
TAAAAACCTG
CTTGTTGTAT
TATCCCTCTA
AGAAGATATI'
AACGCAT
INFORMATION FOR SEQ ID NO:1064: SEQUENCE CHARACTERISTICS: LENGTH: 594 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .594 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1064
AAGCGCTATA
ATAGGGGTTG
TATGGGGTGC
T-rOAAAATCT
AGCGAAAAAA
TTAGCCATTC
~TCAAAAGAC
AAAGGCTAGA
TGGAAAAAAT
AAGTII'CTAT
TACAAGTGAT
TTCTC'TTGA
TTTCAAGCT
TCCAGCAAGT
GC7ITTTTCAT
GCAAGAAATA
CTCTGCTTTA
GCGAACGGCT
TAAAGAAGAT
AAGGCTTII'G
TTCGCCGAAT
CCCAGGCATA
TCAAGATGAA
AAAAGGG
GAAGCGCATA
GCTTTGCTCC
GCGCATCT
AAAATCAATG
GAATTTGAAA
GGGAAAAAGC
AACAGACCCG
ATAAAATGAT
TAGAAGTGCA
AAACGGGCCA
TATACGGGT
GGGTAGGGGG
ACATTATCGC
TCGCCGATAA
CGCGCAATGA
AGTGGGTT G"-
AGGGGTITGTT
AAAAGCGCGT
TTAGAAGAG
GCGTATCGCT
TACTAAAGAA
GATCATCGTG
AGTC7TI A t 6O1 IPEA1J 18 D E~s GCCCTAGAGA GTr-rooocT'T TAAAAGC0CT GAAATCAATC CAGT TrAA AACCCTAAAA CCCCATCTCA GCATAGAGG-c AGCGAITAAA GAAGCCTTAC AGCAACTGcc CTCT INFORMATION FOR SEQ 10 NO:l065: SEQUENCE CHARACTERISTICS: LENGTH: 1221 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feaeure LOCATION I1.. .1221 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1065
AGTCGCACCC
CAAACACACC
AGCCCATAC
GTGGGGGTA
CTCAAACAAG
CA.AGCAGOAA
TrATCCAGTA
AAAGGCOGGC
CTATCAGGGC
TTrGCGTTTOG
ACCACGAGAG
AATCGTCTGG
TCAGAAGGGA
AATTTGGCTT
GTGGGAGCGT
GTGGATTA
AGCAATAAGA
GCCCCTCCAG
AAAAACGACA
CCCAATAACA
AAGGCAAAGA
TTTFGTGCAAA
GCAAAATCA.A
CGCAAGAGAG
TCGCCACAGG
CCGAAGAAOC
AAGGCT1'TAA
AGATTGATGG
AATGGAACA.A
TTAGAAACI'
OCCA.ATT1CAA
TGAATTI'CAA
GTICTGGAGC
TCACTAGCAG
CAAACAGCGT
A'ITTAGCCCC
ACCATCTCAC
CTCATATTGG
AAGGTGGCTA
AGAAAGAGAT
CGCAAAAAAC
CTCGGITrGTC AATCGTrA TCGCCCrrI'A
TCATGCCGCC
CACTGCTGTA
CAATAAA.ACC
TGAAITTCCT
AGGT~rGGGAC
GCTI'GAAGTG
TACTGGTGGG
TGGCCAATCT
CGCTAAAAAT
CGGGAGAAAA
TAAAAATGCG
TAAAI'IAAAT
TCATACAGC
TGTGGGGGAT
CACACTGGAT
CAAGGATAAA
CAGTCAAAAT
AGAAACTGAA
A
CAAAAAOAAA
GITTCTCTCG
11111rCACGA
GGAACGGTCT
CCAGATAAAC
AACAAGGAAT
TGGGGGAACG
OATATOAAAG
GATITrAGACG
TTCACAAGCT
ATTTCAATTG
GCCAGCTCTA
GAAATTTCTC
GGTAATGTGT
ACGATCAACA
CAAAACGCCG
TTGTGGCAAA
CCTAATAGTA
AACAATAGCA
CCCACCAAGT
GGAAOAAAAT
TTTTAGCAG
CCGTGATCAT
CAGGGCTCT
CCGATAAAGT
ACGACTTATA
CCGCTAGGCA
ACGCTGTAGG
TGAATATGCA
ATAAGGATAG
ATAATTTrGT CGGI'rIToAC
TTTATGATGG
GGATGGGCCG
CTCAAAAGT
CTCAAGCGGG
GCGCCGGT
CCACTTCTCA
ACACAGAGOT
CAIGATCGG
OGAAATACAA
AGCOI'rGATT TCCAGCCATr
TAGTGGGA
TTGGCCCAI'
CAAATCCCTT
TI'AIGGGTC
GACTIATAAA
AAAAGCCACT
CGCTGATCGC
AGAAATCAAT
'TITGCAAGCT
CGCCACGCTC
TTTGCAATAC
TCAAGGGGAA
CATTATCGCT
AAATATCATT
AAGTGGCACT
CAI!AACCCA
CCTIT'GTG
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1140 1200 1221 INFORMATION FOR SEQ ID NO:1066: SEQUENCE CHARACTERISTICS: LENGTH: 1278 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: lc~z PCTUS 9 6/0912,2.
780 IPEMJIS 1 8 DEC 1996 ()ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc..feature LOCATION 1 1278 (xi) SEQUENCE DESCRIPTION: SEQ 10 NO:1066
GTAATAAATA
TGCTCTAGGA
GTGTATAGCG
GCGGAGGGCT
GGTTrTGCOA
GTAGCGCTCA
CTCAAACTAT
ACCACTIT
GCAAGCTTAC
TTAGAAGCGT
TTACAC'TT
GGTTTTAAGA
CTAAAAGCGT
GCTI'CTTrIT
TATTACCCCA
GCTCTTTTCC
CGCTTGCAAA
ATAATGTTAA
GACACCCTAA
CTAACCAAAC
ATCTCTTTAA
CAACTAGTAT
TTTTGGCTT
ATATI'CTI'
CTI'ITrCTCA GTI GGTGGG
ATCCCTTATG
GCACCCCTAT
TAGGCGCGCT
TCAATTTIATG
TGTAT'TATTI'
ATCCTTTAGT
CTAAAAATAC
TTTTCAAGCA
TACACACCAC
ATAGAGTCTT
CTAGCATTGC
AGGCGTGGTT
GCAAAGAAAT
TCACTTCOCA
TCTrrrCrTT
TTTCGCTTTT
GCTAAAAAAA
TTACGGGAT
TGTGGCTTC
AAGCTTTrTA QCTTATrITTT
GCTAACCAAA
TGTAGCGATC
TTTIACAATAC
CATGATITI'A
GAGCTATGOC
AAAATTAGGC
AAACAAAAAA
ATL'C7LCCCC
AATCGCTTCT
CCAGCTCCCT
GATCGCGCTT
rr1TTGGTG
CACCGAACTT
AGTCTTITCG
ATGGCTTTAT
TTTAGGTTTA
ATATI'I TAA 77AATCATG
AAA'ITGCCTA
CCGAGCTTCA
TGTGGCGTr
CTCCTAGCTT
AATTTTTGGT
AAACACAGCT
GCCCTITTGA
GTGCT'TrAG
TI'ATGGGATT
GAATATCGT
AGCGTCTTAG
TTTCTGGCGA
?I'AGCCTTAT
AAAAACAACC
GGGGTTrI'GC
TTATTTGAAA
CTCTATCTI''I
GCGAAAT'AG
GCGGCTTCTI'
CCAACAGCTT
CCAATATCCT
ATCTATTCAG
TACGGAGTrC
TATI'CATGT
ACGGCT=GA
ATC TIATT TTI'I GCCAG
TTITCTAAAGA.
GGGGCGTGGC
TATTATTTAA
TGAATAGGGC
GCAATTCTAG
GCGGGAGCGT
TCGCTATCGC
AGCAGGA'rrT
TTCTITGCAG
GGGGGCAATT
TAGGCTTGCT
AGCAAAAAAA
TGAGTTTIAAT
AGGGATTTTA
AGGCTOG
GCGTATr 7I' CATI'AA0GG
GTGCTTATTA
TGAAOAAACG
GGTGTI'TATC
CGCTTATAGC
AAAAACGCAT
TCAA.ATCTTA
AGGGTTGTT'G
TAA.AAAGGAT
CGCTCAGATC
GTCTTATTTG
TATCTCCACA
AATCTTACAA
CATTGGGGG
TAGCCCTAAA
CCCTTTIrGG
AGCGGCTAAA
GCCTTTGTTA.
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1140 1200 1260 1278 GGG'T1FG GITTGCGT INFORMATION FOR SEQ ID NO:1067: SEQUENCE CHARACTERISTICS: LENGTH: 738 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc..feature LOCATION .738 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1067
TTTCGCTTAC
CAGCATTTAG
GTCAATAAAA
CTCATCGCTC
GATCATTrA
TTI'AGTCAAG
ATGCAATTAG
ATTAGAGGGT
WACCGCAAT
CAAGTCCCCT
CAAATAGCAG
TGGTGGITC
CCAATCTAI'
TAGArTrTAA TGGCTCTTITr
ATGAAAGT
TTAAAACGCC
GTATTTTAGA
TTGAAGTGGG
TACCTCAA'rr
AGAAAAAGCT
TAAACCCTCT
CGTTAGCAGG
AGAAAAGGTT
AAAACGGOGCT
GAAAAACGAC
AGAA.AAAATT
AGCGATTG
CAGAACAATA
TTAATGCGCC
AAAGCGTG
?I'rATCGTTA
GCTGGGGAAA
GTTTTAGATG
AAAAAGGTOC
CAACGCATAG
OATTI'AGCAC
CCTTAAGCG
AAACGCAATA
TAGAITACGC
TITTAAAAAA
AAGA0GGCGA
A.ATTAGGC
TGGGAGCGAG
TTTGCGTGGA.
AATGTTACGA
TrTGTCATGT GTGAA TT
AAAAGGGGGT
CCTATTCAAC
TCA.AATI'GAA
TITTTTAGAA
TAAGGGAGGC
TGT3GZAAA
AGAATGCGAT
GAGCTTTrATT
AACGCTTTTC
GGTGATGGAT
t"a1US 9 6/ 09122 IPENIUS 18 DEC 1996 AAAGAAGCCA 1; r ClAACGC 'TTAGAAAAC TTTAAAAACC ATTTAAAAAC CAAATCTTAA CGATCCAAGA AAGCTTAGTG AAAGGGAAAA ACGGGAATGT ATCCAT= CA AGCGAGCC INFORMATION FOR SEQ 10 NO:l068: SEQUENCE CHARACTERISTICS: LENGTH: 2547 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc..feature LOCATION .2547 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1068
AAAGAI=
TGAA~I III
AOACATGTGC
TTAGCGTTIr
GTGTGGTTTG
TATTI'GGCGT
TTAGAAAAAA
CTGI'TGAATC
GACTTTGGGC
AAACTGCCCC
GAGATTTACA
TTTGAAAACA
AACCTCAAAG
GCGATCCCTA
CAAATTTCC C
GAT'GACTA
CTAAAAAAAG
GAAAATCATO
TTACAAGAAA
AAAGAAACGC
GTATGGT1'A
GTGCAAAAAC
AAAGAAACTT
CTGCGCACCT
ACCITITGAAT
GATI'TAGCGA
GATGTCGTTG
TTAGAAAGCG
A'ITGTGGGTA
ACGACAGGGA
AACCCCCCTIG
TATGCOGACA
GCTTTCAA.A
GTI'AAAACCA
TAITI'GATTG
OAGTTTCCTA
GCGACCCAAC
AGGGTGAGTI
GCGCAAAGCIl
AACCGATGAA
TAACCCTATC
CCGCAATCAA
GGG I 'I'AT'
CTTTAGGGCA
AAGGGGAAAT
TTrATGTGCT
CTAAAAGCGT
AACAATGCTT
CCCCATCAGA
AAAACCCTAT
CCCCCTATAA
CACACCCCCC
ACCCCACTTT
AAACGCCCAC
ACAAAACAGA
GCCCACAAGA
AAAACGCTCC
MAGAATYT3AG
CCAAMGAI'A
CTTTAGACGA
TTAAATTGA
TCCGCCCAGC
TGACTTTATIG
GTATIGAAMT
AATTGTTTI-CA
ACCCTTTCAT
GCGGTAAGAG
ATCAACTCAA
TCCCTCATTT
GCGTGGCTAA.
TTGAI'CTTA
TGGTGA?1'GA
TCGCTAGAAT
GCCCGAGCGT
TTAGGGTAGG
TACTAGGAAG
ATCTAAAAA6A
TCATGGCTA
TAAAAAATAT
CCTTI'ATAC
TCTATTAGGC
CGGCAACAGC
GATAPLTGCI'
TTTTACCCT
GCAGGCCTTT
TrCTCAAAAA
TGATGAAAAC
CACGACCTA
TACCCATTAC
AAAAGAACCT
CACACTCAAA
AAACCACAAA
AAACCCACAA
AAGCI'TAGC
CGAAAATAAA
TGAGCCTCCC
AAACGAGATT
TC4CGATAT'
CCCTAGCGI'
CGCTGAATCC
CCCTAACAGC
AAAATCCAGC
CACGGATA
CGTGGGCGTG
ATrAGTGATG
ACTCACGCCC
AGAAATGGAG
TAATGAACAA
TGAAI'AGCG
CGCTCAAATG
GGATGTCGTA
CACTAAGA7T
GGCOATATG
CTTIATTTAG
GGTAATAGCG
TTTGGGTATC
AGGGCTAAAA
ATTI'ATCTI'
GCGCGTTTGT
ATGGTAGTA
TATATIGAACA
AGCCCTAATT
AAAGAAACCA
CACAACACCC
AATAA?1'CAG
ACCATTTACC
AAGCAAGAAA
CCTATCATGC
ACCCCTAACC
AA.AGAAAATA
CCACTAACCC
GAGATATTAG
ACAACGCAAT
GACCAAAAAA
ATACGCACTT
AAGGTGAGCC
ATCCGCATTC
CAA6AGCCAAA
TCGCCTCTA.A
AAAAAGCTCC
AATGCGAT13A
ATCGATCCCA
ATI'ATCACTG
CCCCGATACI
GCCCAAAGTA
GATT GATGA
GGGCGAGCGA
ACCGGCTTGA
GATTCTMA
CTCI'TACCC
CTTZAATCAT
GITTTAGTGGG
TTI'CATTGAT
ACCCTTTTAC
TACTCTIT1T
TTTTACACCC
TCTCTATTT1
AAACACAAAG
TTAGCCTGAA
ACAACGACAA
CTAACGAAGA
AGCCGCAAGA
CTAA.AAGAAA
CCAAAGAAAG
CCATATCCGC
ACCCCATAAA
TAGAAGAAAA
TCACCAGCGC
ACGGTTGA
TA7IGAATGC TCCAGGATTr
ATTCAGGCCC
GTA1'I'IAGG
AAGCCCCTAT
TTATTrATI'r
CCCTAGCTT
CCCACTIGCT
tTTTTATCCT
AAATGGTGGA
ACCCTAAAAA
c?1'TAATCAG3 *ACGGCGTT1GA
*TGACAGGGGG
*GCGGCTI'GC),
TTAAAACCAJ
TGAT1TAG) ccccAGGAAC AGGGGT=rIA
GCGTI'GGG
TAXTrACCC
AGAAATCGTT
GCAATCTAGC
TTTTATAGGG
AAI-ITrATTC
CCT=AAAA
AAAAGAGGGT
AGAAAAAGAA
ATCGT1T'1TA
AGGCTTAGTC
CCGATI'TGAT
AGAACCCACG
ATCCAACACA
AGAAGATGAT
TATAGAAGAA
TAAMAAACCC
1'TATGGCGAA GGTTIrGcTrQ
ATTGAGCAAG
TA'X GTAACC
CTTOAGCGAT
CAAAGGTMNA
AAGAGAAATT
AGGCAAAGAC
CATCGCCGGC
ACTTTATAAA
AITrrpGCATT
AGCTATCGGG
CGAATACAAG
AGCGTTCCCC
CAAAGAAGCG
CCTCATTGTG
CTrGCCTTCA
CACCOATG
AAACGGGI'TA
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1140 1200 1260 1320 1380 1440 1500 1560 1620 1680 1740 1800 1860 1920 1980 2040 2100 2160 2220 PCTUS 91; IPENUS 180DEC1996 GTGCGCImC
AAAGCCCAAA
rI'AGACACCC
GAAAAAAAGA
GCCCCACCA
GGCAACAGAG
ATGCCCCCTr
AAGAGGTG-GA
CTAACTATCA
TCACTTCTAC
T1'ACTGACGA AGATII1'MCA
TGCCACTGAA
ATACGATAAA
AGGCGATG3AC GAGC 17111 A
ATTAGAAGCT
AAA'TI
GATGAAATCA
GA'ITTCTTGC
ATTCTAGAAA
CAACGCCAAT
CAAGGCT=
AAAAAATCGT
TAGAAGAATC
GGGCTAAAGC
TAAAAATC-GG
TATCCCCAAG
GG.ATI~ATT
GCGCATGCCT
GGTr.AT=IA
CTACAACCAA
A.AACG;CCAAA
2280 2340 2400 2460 2520 2547 INFORMATION FOR SEQ ID NO:1069: SEQUENCE CHARACTERISTICS: LENGTH: 1344 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc...feature LOCATION .1344 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1069
AATTACCTAA
AAAAAAC CCT
TTTACGCT'
CCTACTCTAG
TrGGGGAGTT
TATTCCATTA
ATCGTAGGGG
GT'GZGGGAG
AAGGT'=T
rTTCGCTCT
CGTTATA
ATOGAAOAAA
AAAGAAACCC
AAAGCCTTAA
ACGGTGTATT
TTTATCATGC
GCGGATAAAA
ACGCCTA7Z'G
GAAATACTCG
GAATTATTCC
OCGCTT=T
GAGGGGTI'IG
TCCCTAAAA
AAA?1'TCATG TTCAAk TAA.AATCCCT TTTAG ATGCGTTCCT TGCTCI CGCTCATCTC AGCT TGTTrTGG TAAAT TCCIATGGC GCTAG AATGGGCGTI CTTGT AATATGGCGT GGTCG ATGGCTCTI1' CCAA TATCGT1'GA AAACG
TCGCTTTAGAGOT
CTATGGATAA TGAAG ATATCAAAGA AACCC TGATAGTCTT TGGGC TPIAAAATCTT 'I 'IAA TTTITAGCGCT CTCT TCA).ACGCAC CCAAA TCT'TrATGG TATC~ CATTGAGCAG CTG CTGAACATGT GCGAC
GAGGGAGCGCGA?
TGGGCTATGT CATG) AAACCTATI'T GOAG 3ATA
.CGCT
CT
TTTA
CCACT
ATGTA
TTTAC
TATTA
COACT
AAAGA
TAACT
CCAAC
'AMI
ITCTO
LAGCAT
4=IT
CGCTI
.ATATI
MGAGI
GCCATGAACC
AG7ITCAGGCA
TTCGCTAAGG
GTZTTATGC
GATAAAAAGG
TTCATGCTCG
?I'GTAGCCA
TATCTCTCTG
ACTTTAGTGG
ACGCATIGAGC
GCCCTACTCT
CCTCAAAAAA
GGCAGTTTAA
ATG3GGAGGGA
AGCTCATCGT
ATCTTCTrAC ATGGT1T1TTG
GCCACTAGCG
TACACI'TGCA
GOCGTGGI1 GCG~rAGAGI1 ATrGTrATC1
CCCAGATTCA
ATTTAGTG3GA
AATTTACCCA
TAGGGIT=
GGCGTAAAAC
CATCCTCCC
GGCMACA
AArrAGGCAA
GAGGGCAACT
AAATCAGCGC
CGCTC ri?1'
AGACTAATGT
AGGAA~TTCT
TTAGCCCTMA
?.ACCCTTATIG
CGATCACAGG
TGTATGAGC
TTGCTGGGGT
TAGCCTATGC
ITCAAACAGCA
TTIA.TGGTTAT
PCCCGCCACT
ATGGTATCAT
CACCAATGAC
CATGCGCCCT
TrCCATGGTG
CACTAAAGAA
GGGCTT'AGC
GAATGGTAAA
CI'AGCTA?1'
GTTTGCTTGG
GAGAAATATC
AAATAATACA
CAACCATAAA
TTACACTTT
AGAAAGCAGT
CGGGATGC
1 Ir
GCTT'ATTGTA
CCTATI"ITAT
TATTAAGGCG
GATCGCCAAT
TGGI~IWZAA
GGTTrATCATA 120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1140 1200 1260 1320 1344 INFORMATION FOR SEQ ID NO:1070: SEQUENCE CHARACTERISTICS: LENGTH: 1938 base pairs STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) PUTUS 96 0912a.
IPL#VtJS 16 DEC 1996 783 (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION I1.. .1938 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1070 AATGGAAkA
AACACGCTTC
GTGTOI'ITAG
ACCAACCCTA
T TAGTGTATA
TICAGGCAAT
GAAATCACCA
AGCCAATACG
TGTGGGGATG
CTCGCCTTO
ATTAATATTA
CTAGAATGCG
TCCCATAAAC
GAGGGGAGTG
GAAAACGCTC
TTGAAGAAG
CCTAAAACAA
CCCCC=IA
GCTATCGCTA
AACACGCAT
AGGG-AGCATG
TTTFGCGCGA
TTAATGAAAT
CGGGCGACGC
GCTTCAGGC
AACGCCCCTA
AAAGAGCAGG
CTTrGTrGCGA
GAAAATATTC
GAAAGCTATT,
ATAGAGTGGT
AAGGGCGATA
AAAAGGTAC
A'TTTGATGCA
GCT7TTGTG
GGCTAGCTGA
AATWGCTCAA
GTI'GI'GCA
TACACTCTAA
CAGCGCCI'T
CTCAAACCCT
GGGA'I TGCA
ATAATCTCAT
GIITAGCGA
ATGGGCATGA
CCACGCTI'
AAAAAACGCA
AAATCAATCC
TGAAAGTTAG
AAGAAAAGAT
AAAAAGGCGA
AAGAATGCGA
TGAAACACTC
CCATGGGGGC
CC~T7'GT T.rAAAAGCCCT
ACCAGCCCAT
CTAGCGATGC
GCGCTCTTAT
ITTCTAAAAGG
GCGGGAGCGA
CCACTCAAGT
TTAAAGAACT
ATCGTTTTGC
AACTCI'TGA
TCAACGCA
ATTGAGTAAC
TGCGOACATG
TGTGATGGTG
TAGGGACAGG
TT'TGGGGC
AACCCCAGGA
AGGGCAAGGT
TI'AGATAAA
AGAAGGCATT
TGTGATTTAT
ACAGGTI'AAA
CTATCAAGCG
AATCGCTCAT
TGGCTCGCCT
TAACGAAAGC
GGGTATTAGT
CCATGCGTTA
ATCTCTAGCC
GGGCTTTTTA
TGGCGATTTC
TATCACTAAC
GTTAGCGAT
rTI'TATCTrC AGAOCAATrG
TTICIAAAAT
TTTATCGCGC
OGCGTATGTT
AGTCTCTTTA
AGTGAGCGCG
CTI'rAAGGGT
GGATAAXATC
AAAATTTGGC
GCTGATTTAG
ATAGATAAGG
GTTTAAGCT
TT~GGTTTA
CACCCTGAAT
TTTG~CTA.ACG
GAGGCGATTT
AG'rrATGAGA
GACAGCAACC
ACACGCTI1T
ATTCATAACG
ACGATCAT1'G
TTAGTAAAG
TITATAATTA
TTAGAAGCCT
AAGAATI 'TG
ACGAGAGTGA
GGAGGGAGT G
CCTTTAGGGC
GCTTTAGCGG
TXITrAATGC
ACGCATGACA
AGCCATrI'AC
AAGGCTTGCA
CAGAATTTGT
AAACACCACT
GCTTTAGAGA
CCATGCITTTG
AAAGTCTTAG
AT1TGGCATGG 7ITTAGCGTTG AACGATA.A.A AAGCATGGCG
CTAATAGCGG
TG3CACCTCAA
GCGGAGGGCA
GI'TAGACGA
TACACCACAC
CTGTAGGC'r
CTCATAAAGT
OCACTI'CTT
AGATCAGCAT
TAGCGCAAAA
C TIAGAAGA
GTAAGGGGGC
AAGTGTTGAA
GCCCAAAAAA
TATW3GAAAA
AITTTAACGC
GTAACGGCAT
CGGATrAGC AAAACCT1GCA CGTATGGCTr
CTAGCATICG
GCATTGGGGT
GAGCCTTGCC
TGCAAGTICGC
CCGTGCTTGA
CTAAAGATCC
GCGCTAA.GAT
ACTTGTTGGT
TGATTGAAGC
ATTCrTTTGG
AAAACATTAC
GCATCCAGGC
CCTAAACCCC
TrCGAGCGCG
TTTAAAGCGT
CGAAGGCATT
TAGCATGGCG
CTATrGCI'G
AGCCGGGCAC
TGAAGGCGCT
'rrGGGAAGTG
AGCCAAAAAA
TATTGGCTTA
ACAATCCAAA
CAAATIGCAT
GTCCTTAAGC
CATTAATTAC
GATTTTAAAC
CCCATCCAAT
T7IGGGATC
GITI'GTGCCT
TTTGAGCGCT
GGGCOAAGAC
GCAI'TCTAT
ATTAAGTT
TGAGGTrCT
CATTATCACG
TTTAGAGCGA
AGAGC.AAGAT
GACCCGCGCG
GAGCTCAGCA
CGCTCAAGCG
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1140 1200 1260 1320 1380 1440 1500 1560 1620 1680 1740 1800 1860 1920 1938 INFORMATION FOR SEQ ID NO:1071: SEQUENCE CHARACTERISTICS: LENGTH: 819 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO vi) ORIGINAL SOURCE: N 7_ ORGANISM: Helicobacter pylori POUS 9 6/ 091~2 IPNU 'f-ADOEC1996 784 (ix) FEAT'URE: NAME/KEY: misc..feature LOCATION 1 .819 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1071
AAGGATTAT
AACCGCTTGG
GACGATGCGA
'rrAGAAGATC
ATCTATCAG
CTAGA'LT1'G GCT1'ATACCA
GG~TAG
AACGCTGA.AA
ATCAAOCCG
GGGCAAAACC
ITAAGGCAAT
ATTGAAATCA
ATGAACGCTG
GCATGCAAAA
ATTTAACCTC
TACAGGCGA
AAACCAAAC
AAATCTATAC
CCCTAACAAG
AAGACGGGCA
TGCTTTCACG
TI'GAAGTGGA
GCCCGTrGGC
TTTATACCTA
CCATGCTAGA
ACCGCTII
AAGCGATIrAA
TGGGTATTAT
TAACAATITA
7'rMAAGG
GAGCGCGAAG
GGATAGGAGT
CCCTAACCTC
TTITCAGCGT'
CTCCGGT'TG
TCAAAATCGT
TTITAGTO3AGT
TCAGGGCGAA
AAAAAGCAAT
GGACATGTAT
CA.AACTCGCT
GCGGCCACAG
GCCAACCTAA
CTTTACCAAG
TATCTCAACC
CTGGCGCGT
TATITTTGCGA
GATAAAGACG
AACGAAA.AAG
GGAATCACI!
TTTAGCGAAC
GGCGTTCATC
GTCAATGCGG
TCTAAAGT<;C
ACAAAAGCT
GGGCAATGGC
ACACCAACGG
AATACCGAGA
GCAACCTCAA
TIGAAGGGAC
TACAGACTAA
GCTTTI'rGGT
GAGGGATCAT
TTAGGGATAA
CTAAAAATCT
AAGTCTCTGA
TGCGTGAGAT
TAAAAACCCA
TACACAATT'
CTTTAAALGA
GCAACTGCCC
TCGTGTGCCT
GAATAACCCC
TGAGGGCGTC
AACCCTTAAT
GCTCATGCCT
TGAAGCCCAA
TAAAAAAATA
CTCTGGTGCG
GAGCACTTTG
TCAAGATGAC
120 180 240 300 360 420 480 540 600 660 720 780 819 INFORMATION FOR SEQ ID NO:1072: SEQUENCE CHARACTERISTICS: LENGTH; 1776 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .1776 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1072
GGAATGATAG
AAAAGCCCGC
CCT1'ATTTGT
GAAAATTTAA
AATCTI GG
T=CAATT
GCAAGAATGT
ATAGAAATCA
GACGCTAAAG
AAAAGCCCTA
GITT CAACCG
GCAACGCTTT
GATATTGTrGC
TTAGA'Z'I'TC
CAAGCGA'TTC
TTATTTGC
AGTGG
cAAGCG
GGATA
CGCTOAM'zTr
TAGATTCAAG
ATTATITGG
AACGCTTGGT
ATI'II'CAC
ACAACATGAT
ATGATTITAAA
ACCAGCATT
ACGCACTCAT
GTTAGTGGA
GGCCTAGTTT
TTrGCATAGA
TGTCTTI'AGA
AAGAAGGCGT
AAAAAGGGGT
ACCAGTATGG
TGCKITCTCG
GTAACAGCCA
AAGACAAGA'I
CAACCTCTITA
CTrAGAGCTA
CTTGGGTAAT
GGTCATrCAG
TGAGATITTA
TGCTCATTA
AC rMTr AAC
CACGCGCGCT
AGGCATCAAA
TITTTGTGAAC
AAATAAGCAA
CGCT'CTI'C
AAGGGTGGAT
TAT ITTTGCT
TAAGCAATC
TTATGTGGGC
TTTCAAAAGG
CGCTAGTGGG
?TTTATAGAA
GATAAAGAAA
TATAAAAATA
GGGGTGTm
CCTGAAATAG
GAAAATCGTT
TT TGATATOG
GCTTATTATIG
TTAGAGCATG
CAGCATGTCG
~CTTTAAAM
CTCCCCCT'1
CCTATI'CTAG
?I'AACGGCGA
CTGACTTCCA
AGITTTCCGCC
ATAGGCATGA
TGCGTGTTTA
GCGATTI'ATG
*AAATACGGGO
-l
CAAACACGCC
GCGAAAMTCA
ATCGCTCT
AGGTGATTIT
TGATrrATT
ATAAAAAGTC
AACGATACTC
GCGCTATTAG
CTAA7I'rGC
ACAGAGACAC
TAAAAGAA.AT
CCAGAGCCGG
AATTCTATGA
?I'GTGCATA.A
CCITTTGGCTA
GCGCAGCGAA
TCGGGCAAGA
GCGATAGAGA
GTAATGGGAA
CTTATTTGAA
CATGCTCTAT
TrAGOCAAT
CATTGTGCTG
GCATGCAAGT
TCGTTTATAC
TCATCAAATG
CGTAGGCAAT
TGAAGTCATC
CGCTATI'ATC
CGCTCCTTAC
TATCAAGCCT
AGAAACCCCC
ACGATTGATI'
TACCAACCTT
CATGGCGTAT
TTTGAGCTTT
GATCAAGCCT
AGTAGAAACC
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1140 PO/US 96 091 IPEA'US 16DE~C 1996
ACTTAGTGT
AAATTAGAAG
CCcTTrAAAG
ATTTATCCCA
GAGATCATCA
GCAGAGTI1T ITIrGAAGAAT
AAACGATCA
CATATCGCTG
TTAGAATACA
GTGATAGAAG
GGAAACTr'rr TCAT'rAACGC
AAGTGTGCGA
CCCAATCAGA
AATACGCCAA
TAGAAAAAGT
TAGAAAXITTT
ATTCGTAT
AAATCGTGTG
'TTTACGCGCA
CGATCAAAAT
CTTAGAATIT
TACTGAGG
AAAAATAGAC
ACAGGCTAAA
TG3AGAAAAAA
GGAAAAGCTT
GAGCGCTGAA
TATGGATGCG
TAAAAAAACG
CAAATACTGG
GGCTI-DOAAA
TTTGAAAAAG
GGGGCTAGGA
AAATCCAAGC
AATTTAAAGA
ACGCAAGTI'G
CATCGAAAAAA
ATTATAACG
ATACAATC?1' AGTAATG3AAG
CTTTAGTT
GAATG
ATAT'T'MAA
TTAAAGCGAC
CAAAGCCTCC
TCGCCAAGAA
AAGAAGCGTT
ACAAATrAGA
TTAAAGAGCT
ACATITCCA
ACGGAI'rAAG
TAGCGGGTGG
CACGCCCTAT
TAAAGAAATG
TATCAATC T
AAAXATGCGAA
TTTAAAGGTG
AGAGTTGGAT
IT=ATGAC
CCAGGAAT
GGCTAAGCAA
GATGGATTGC
1200 1260 1320 1380 1440 1500 1560 1620 1680 1740 1776 INFORMATION FOR SEQ I0 NO:1073: SEQUENCE CHARACTERISTICS: LENGTH: 348 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .348 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1073
GTGCA'Z=A
CAGGCGTGCA
ATCCCCCCTC
TI GGGGCTT
AICGGGGGCT
GCGCATTGCC
CGTGTATCIT
AAAAGCCACC
AAGTATrAAC
TGAGCAGCAC
TrGAGCA'rrA
GAATTGAATG
TCTAACCCTA
AACCAGATCC
CCCTCAAATC
TTT'AGAAGCC
TITATCCCCT
CAAAAAGACG
?I'AAAATGGA
ATTCAAGGTC
CAAGCGGGTA
CCCTTATI'GT
TTATATGGGT
CCAATGAAGT
T TTTGCCAGC
TGCAAAACAT
TACAAGGGGT
TTI'CTAAGCA
GGGGCAAGAT
GTATCGCT
CAAAAACAAG
CCAGCAAAAT
GATGCAAGGT
AATGTGGTG
TCACGATGGT
120 180 240 300 348 INFORMATION FOR SEQ ID NO:1074: SEQUENCE CHARACTERISTICS: LENGTH: 1131 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1 1131 POT/US 96/0912.2 IPEA/lJS 18 0E C 1996 786 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1074 CGCATGAA1'
GTTTTATTGA
TTGAAAGACA
TCTAGGCAAT
CCCTCTATGC
ATTCCCTCTC
GCGAACGCCA
AACGCCTTAA
GGGACAGACG
AA2TrACGCGC
AGCATGTTA
TTAAGGCTGT
TAI'TIGGGG
TT7TTGAACA
TGGATCAAAA
TTTATGATGG
CAAATAGTGC
GAAT ATAG
ATAGGGTGCG
?TTTTAAAAT
TCCTTATAGG
T CGTAACGCA
TAGCCTTCAT
TGGAAGCCAA
ATTTTGAAGC
ATTACTITT
ACGATGAAAT
GGATTAAGAT
TCTCTAGCGT
CTAGCTCCAG
GCGCAAGACT
CGCTGTITC
GCGATT
ATGAAGCCCA
GrTTGTGTG
CTGCTTATCA
ATG'TrTATAT
TGTTCAAACT
CCTTTTAATG
CGCTCCTITA
GCAAAAAATC
GGTGCAAAGC
AAAGCTTIA
CAATA'ITTAT
GA'rrTATGGT
CAGGTTCAAA
TAAGCCTATC
GCGTrGGAA C'rrGGTGTTC
'TTIATGGG
CATGCTTGCG
CACCACTCAA
GCCTTTrGAA
TGGGATCAGT
CCATTTTTAC
CAGCTCTA
GAGTTIAAGAG
ATCTATGGCT
GCCC~TGTAG
TCCAPLCGAGT
AAAGAAGAAA
AAACAAGTGC
GCGTI!AGCGA
CGCAACGCCC
GCTTTGTATA
ATCI'ACACC
TTGGoCCCTrr
ATGGGGGCGT
ATCGAACGGC
GCCTTGAGTT
ATCGTTTGA
TCCT 'OCCCT
TGCTCGGGC
GCGCTTATTG
AAGAAAGCTI'
CCATTGTC
TGTrATACCC
ATGAAGACAA
TAGAAATCGC
AAATITATGG
CTGTAACGAT
ATGCGGTTGT
AAATAGAAGA
ACCCTAGTGA
AGGTGATGCT
TAGACAAGAA,
TTAGCGTT
ATGGAAGCGC
TGGGGTCGTI'
TTT~CrCT
CTTATTGCA
GATTGAATCA
CGATTTTAT
GTGAAAACGC
TCATAAGGGC
TITTGCCTTAT
LrCCTrrCr
TPI'CITAGC
GATCTTACAC
AGATT'TTTAT
GGGGAGCATC
AGCTGAATTA
GGGGTAITG
CATI'GCAAGC
ACAAATCGCT
TGTTTTTIA~G
'IITAATGGTG
TTTAGGGGCA
GCCCTTGAT
AGTCTTCGTT
TATGCATGCG
CGTGAGTPITr
T
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1131 INFORMATION FOR SEQ 10 NO:1075: SEQUENCE CHARACTERISTICS: LENGTH: 267 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO- (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc..feature LOCATION4 .267 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1075
ACCTTAAAAG
TrTITTrGTCG
AAACAAGAGA
AGCCATCAAG
ACTAGCCTTT
GGATTGTT
TGTGTrI'rAT
CCCCAAGACA
TGGCGTTGA
CAGAAGCTAA
GTT'CAGATI'G ATAAGCGCAT ATT GCCTT TGTTTAGGGG GCTCCCTATC GTGGTGGTGG ATTAGGCGCA ACGAGTGCGG
ACGCTTT
GGGT 'TTACA TTT'1TAGGCAC
ATTTGGATAA
TW AAATCAA
AGACAAGTC
GCAAATCT'I'
GACCACTACA
ATACCAAGTO3 INFORMATIONl FOR SEQ ID NO:1076: SEQUENCE CHARACTERISTICS: LENGTH: 231 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO 1,- POT/Us 9%/f912 IPE~1jS i 6DEC 1996 797 (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscEeature LOCATION .231 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1076 AGCATGAAAA AAACAACCCT CTTTGTATl'G GGC2V1ATTAT GTI'GATGGGA TTI'CTCAAAC CGAGCCTCT TCTrI'GAATr TrGAACCATT CTAACGCCCA AAAACTCTCT TAAAAAACG AATCATGAAG GCTTGCATGC GCAGAATACG CCAITAAGCG
TCAATAGCTC
TGGCTC3AAGA
CATGGAATAG
AGCGAGTAAA
TTTAAGCGCT
TAGCCTGCCT
GGTGTIGTCT
A
INFORMATION FOR SEQ ID NO:1077: SEQUENCE CHARACTERISTICS: LENGTH: 303 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-.feature LOCATION I1.. .303 (xi) SEQUENCE DESCRIPTION: SEQ I0 NO:1077
GTAAGGAGAC
G'I rr AATGG,
AAGTTTGA.AA
ATTIAAGAGG
CAAGCTAAAA
AAACTATGAA
CAACCGATGT
AGAAAGCT
ATCTTATGGC
AATTAAGCGA
AAGGTI'AT
TAAGGCTCTT
AGGTAAAAGC
TTTTAAAAC
TGAAGACATC
GT=GTTTAG
GTAAAAGGTT
AAAATCGI!A
GGTGCCAACA
AAAGCI'I'IAG
GCGTIlrGGC
GTGCCGCI'TG
ACATGATGAG
AGAATCCTGT
CCATATACAT
GI'CGCAAAT
CCATGvGGGTI'
CGAAAAAGAG
CATGACCGCG
CCCCACTCTC
INFORMATION FOR SEQ ID NO:1078: SEQUENCE CHARACTERISTICS: LENGTH: 477 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori AMENOED SHEEF POUS 9 6/ 0912.
IPEAAJ 18Dr'c 1996 788 (ix) FEATURE: NAME/KEY: misc-feature LOCATION I1.. .477 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1078
AGACCTATGC
TACCCTAACA
TTCCCCCAAG
CTAGAAGAAA
TATGATIV1CC
TATTI'TTTAG
TTAGATCCT
CGCCAAGTGT
TACATAAAAA
CATGCCGAAGT
GAGGCAT'GA
TTGGCACGAA
CAAGCAACAT
TGCGCCTAAA
ATCAATI'CAT
ACCGCCAAGT
ATATCGTCCT
TTATCGCT
TGAGGGAGAG
TGAAATAGAG
GGAGCATAAA
GCATG?1'AAC
CCAGCTTAAG
CATCGCTTAT
AATGTTGCGG
GACCATAG
ACCCCTTTAG
ATITrGGCGC TTCTATrCGT AACATTGATr GATIrGCTT~A
TITTAGAAAAG
CCATTATCAT
ACATr GAAGG
AAGCACTCTA
AATACCCTAG
?TGACGGGCA
TCAACAAACA
AAAAAATCGT
AGGGGTATITr
GTCGCCAGAC
GGCGTGGCAG
TAGAGAATrA
ATGGATCGCC
AAAGCAGCGT
CACGCCAGAA
TCCCTTCAAA
GGGGTGT
120 180 240 200 360 420 477 INFORMATION FOR SEQ ID NO:1079: SEQUENCE CHARACTERISTICS: LENGTH: 393 base pairs TYPE: nucleic acid STRANOEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc..feature LOCATION I1.. .393 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1079
TGCATGAATC
TATT=lTGG
ACTI'AGCG
AAAAAAGT
ACGACCT
GAAGCCAITTT
TGGGTI7I'OG TTGTCT1'
GCAAAATGAT
TGAATCTCAT
TTGGTGATGA
CTrCTTATGG
CTTATGTCT'
CTAAGAATTT
GTGGGCCGCT
GCCCAGTAAA
AGGGTGTWITI
7vIrI'GATT
GTTAGACACT
AGGCACTAAC
TGTAGGCGTIT
CTAGGAGGG
7IYIVITAATGT
ATCATCGGCT
TrC7I'rGTAA
TAAAACTCT
CTIrAGGGC
AAT
CTATAGOGAG
TTGAAAGT'
TTATGGGGCA
CCGGAGTTT
TWCAAAAATC
TTA'rIGGGGT
CTCGI'AAGG
CCCTTTAGGG
TrrGGCCGcT AGGGGGTrI'r
CCAATACCTT
AGCTATCGGT
INFORMATION FOR SEQ ID NO:10S0: SEQUENCE CHAFLACTERISTICS: LENGTH: 819 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori Pci-us 9 6/O09 1*? IPENs1JS 0 E 0C1J96 789 (ix) FEA TURE: NAME/KEY: misc...feature LOCATION .819 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1080
TATITTATCAA
AAAAGCCAAA
GGGGCAAAAG
TIr GGGCATG
GCTGAAAGAA
TCTGGCTCTA
GAGTGGGGAG
GGCCTrAA
AAGAGCAI'IT
AGGATCT13CC
GAGGTAGAGC
GATGAGCTT
TGTTICCACT
AAAAACCCTA
TCGTGGTGGA
GCTCTGTGAT
CGATI'GAGGG
CGTI'AAGCGG
AAGCGI 71A
TTAAAGCCCA
AAAAAGCTTA
ACCCTGATGT
ACCCTATTGA
CCAGTAAAGA
G7T'TGAAAGA
TAAA.AGAGTC
TATGCCCTT1'
AAGGCGAAAA
AGATCAGAAA
CATTGAAGAC
GCTTIAAAA
GAATTTrGCAC AAATI'TAGTr
ACATGGCACA
TAAGATCCAC
GATCATCACA
AGAGCATTTG
TTTATCCTA,
AAGGOTAAGT
TGAATACITA
AGGGATTGAT
GATCTGCTIC
GGCATTTCC
GTGTGCTTCA
AAACATGGCT
ITTGTCGTTA
TCTGAGATGT
GGCAGGATCG
AAACAAATCA
AACGATAAAG
GACATGTGCA
ACGCCACGAC
CATGGTCATG
GCGCATOCCA
ACCGGGAGTA
AAAGATTCT
CTATCGCAGC
GCAAAGAGGA
TT'AAGGATAA
CGCCCATTCT
TTITTAATGGT
TAGCCCCTT
AGGAAI'GTr
AAATCCACAC
TGGAATGT(G
AACGCATCGT
ATGAAGATCA
CTTGCGCGGT
TCGCTTTAAA
GTCAAAAAGA
TTI'GTAGAA
TGGCATTA'ITA'
AGAAAATGAA
GAGCAAAAGC
TGTGGAAATG
TGATCCTAAT
TAAAAA'TrTA
GITI'TGAA
CATCCACAGA
GGTTTI'ACTA
GTCCCATAT13
TCATTATCAA
120 180 240 300 360 420 480 540 600 660 720 780 819 INFORMATION FOR SEQ ID NO:1081: SEQUENCE CHARACTERISTICS: LENGTH: 723 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc-featur* LOCATION .723 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:lO8l
TTGACTAAAA
CAGCAATTTA
TTrAGCCGGAT
ATAGAGACTA
ACGCCTI'rAA
CCCCTAA.ATT
AAAGGCATGA
CTrTTGATG
ATCGCTAAGG
GTGGAAAAGT
GATOTC.GGOG
AAA
AAAAGAGTOGC
CTrATGGGAG
TAGGGCTTT
TGAATTTGAA
AAAAAAGCGT
AAGCGATCGC
TGTTAAAACG
GGGAAAAATT
AGCCGGTGGC
AG'TrAGCCA
ATTAGACAG
AATTAAAA
GCAATTGG
TTTAAAAGCG
AGGGCCTAAT
CTATCAAGGG
GGCGTTTTTA
T'I'I'TATAAG
CTCAGCGTG
GCAGCTGATT
T=GA IOAC
AAACGCAAGC
CGCGAiir'
AGGGTATAGC
GGATTAAA
CTAGACAATA
GGGGCGGGTA
GAAGTGAAAA
AGCGATGGCG
GAT~?!=A
CCI'TAAAAA
TTAACCCTAT
CCTATTGCAA
TrGCTAGTCT
TAAAAGAAG
AGITTGGAGG
TGCTAGTAGA
TCAGTTTGAA
AAACCACTCT
TTTAAACCA
ATTTTAGA
GCGATI'rrGA
GAGAGTTCAA
CACGAAACGC
GAGAAGAGAT
CTACGCATT
CTAAAGTGGT
CAGCGTATAA
AATAGAGAAT
ACTACCCAAA
G'I'rAAAATT
AAGATTGGT
TCCTAAATrA
TGAATCAAAA
AGCCCTCA
TrCTTGTAT
TTTTGAGTTA
GGTGGTGGAT
GGCTI'I'IGGG
AGAAAGG7I'G 120 180 240 300 360 420 480 540 600 660 720 723 INFORMATION FOR SEQ ID NO:1082: SEQUENCE CHARACTERISTICS: LENGTH: 864 base pairs TYPE: nucleic acid POT/US 9 6/ 0912) IPeNUS 10 UtG uS6 790 STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobactar pylori (ix) FEATURE: NAME/KEY: misc~feature LOCATION .864 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1082
AAATCGTGGT
GGGCATGGCA
TI'GTAITT'G
CGATT'GACA
GACAATGTGA
GCGGATAAGG
GTTTATAGGG
AAATATGAGA
GCGGATAI'G
TOCAGCAT
AAATCGCAT
TTGCCCTATA
TTrGGCACTT
AACTCATOGG
TTGAAGCGC
TITTTCTATGC
TGAAGAAAAA
CGGTCTTr
AACAAAACCA
TAACCGCCTC
TGCGTTATGA
GCGAGGGCT
TCATI'CCC
CTAGCGGGAA
ACAACCCCAT
TGTCAATGTG
T TT'CATGTC
CCCACTTAGA
ATATGACCTT
GCTACATCAA
CCCTITI'AT
AGCAAAAGTC
Trl'GIGAGC
TAAGATIWITI
AGGGAATGCG
CACCAAGACT
GCTCGTTAAA
CT1TT'ATGTC
GGATCAAAAA
TGGCATGTC
GAATCCTAAG
CACGAGCAAT
CGGCTTTATT
TACCCCACAA
CCCT
GGTTTGTGGT
~TTTGGTGT
GTATCAGACG
GAAATCCTTG
ATCCTATTGA
AAAGAAGCGT
ACCGATTATG
CAAGACAGCG
TATAACATI'A
AATGCGACTI'
ATTATGTCG
AAAAGAACTA
TATTTGCAAC
ATCCGTTACA
GTTI'AAAAAC
GITI'IAAAAT
CTAAAGAAAT
CGGATAAAGT
ATATGACGT
TATTAGAAG
TGAAATTGAG
TGAGCGGGAT
AAAACATGAG
CAGGCTCATT
GCGATATTCC
CCGGGTTZ
CC'TITATI'I
AAAGGGGT
CCCTATCATA
GATTCGTTG
CGCTATGCAA
GAGCGCCAAA
GTATATTCTA
CAATATTAAG
TTTGAACGAA
TTGGGTGAGC
CGCTTCAGGG
TAACATGCAA
TGTATrOTAT
ATACCCTCAG
AGCCCCCAAA
TGGCTTGAAT
120 180 240 300 360 420 480 540 600 660 720 780 840 864 INFORMATION FOR SEQ ID NO:1083: SEQUENCE CHARACTERISTICS: LENGTH: 447 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc..featur* LOCATION .447 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1083
ATCGTTAGAA
TCTGTGATGG
TTTATGATCA
ATCTATCTTG
TTTATTTGGG
TrGTTGTTCA
AAAAAAGAAA
AGAAGI'AAT
CTCAATCC7I' ATCTrACAC
TCATGCCAGC
CGATGCAACA
TGCTCATTGC
GGATGAAAGC
G?1'AGAGATG
GCTI'GTCCAT
CCTTTTAAA
GATTTATATT
ATTTGAArI'
AGAAATCAAA
CTATATCAAA
AGTTTGCAAG
GCCTTTTTIIG
GAAAAGAATT
CTTTAAGCA
TCTTTTAGCG
CGCCATAAAA
AAAGCTAAAA
CATTAAATAC
CCGCCTTGCT
TCATCCAATT
TCGCTCTTTTI
CTGTTGTCAT
GCGTGAA
TCCTGTA'Tr
ACAAGATTCT
CGCCCTAGCC
GAACCGGAAA
GAGTGGGGTT
GC TGGGG
CGCTATCACT
'TTTAGAAACG
POUS 9 6/ 09122 IPENIJS 16 DEC1996 791 ATT CTATCA 1'GTGTIAAT GGGCATr INFORMATION FOR SEQ ID NO:1084: Ci) SEQUENCE CHARACTERISTICS: LENGTH: 357 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION I1.. .357 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1084
CCAGAAGGAG
TCCITTTGTGA
ACGGCTAATG
CTCAACCCTC
GATCGCTCTA
GATATTTTCA
GGAATGAACT
TTTTAGGGTG
AAAAGATTT'G
ATATCGGCTA
TCTATGATAT
AGCCAGAAAA
CAATGTGFI'
CGCGATTGAA
CCACGATTAT
TGAAAAATCC
CGCTTTAGAA
CATGCTAAGC
CAGCCGGTA
ACTTTAACGA
GTTTTTAACA
GCTATGATCG
AAGAAAATCT
CCTCACGCTT
TCGCTTACAA
CTAAATGCGT
GCATI'GCAT
CCAAAGAAGC
TAACCAAAGA
TCAAAAAGCA
GCTITI'CCAT
GGAAGGCATC
TGTTACCCCG
CTAAAAAGC
GCAACTGGAC
TAAAGAC
INFORMATION FOR SEQ ID NO:1085: Ci) SEQUENCE CHARACTERISTICS: LENGTH: 705 base pairs.
TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (gonomic) Ciii) HYPOTHETICAL: NO Civ) ANTI-SENSE: No (vi) ORIGINAL SOURCE: CA) ORGANISM: Helicobacter pylori Cix) FEATURE: NAME/KEY: misc-.feature CB) LOCATION .705 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:lOSS
AAAAGGCTTA
GCTAGAATGC
ATCTTTTATT
TTGAATGATT
GCGTTAGTGT
TITGCGTCTA
CATGTCG'ITT
CTCACTTTTA
TGGTITGT
TTAATCAA
ACAATGGCGG
ACGCTCATTC
ATTCTrAT
?TTTTTACAC
TAGAAGAATT
TGCTTF'AT
TCTATCCAT
TCrI'GGCCCT
GAGTATTGTG
TCAAGGC T
TITTGGATC
CCCITTAGTG
TGGCTCTATC
CTTAGCGG7I'
TTTAA
ATCCTTTTGA
AATTATTGCC
TI'GCCGGTO
GTAATTCTTT
GTCTCTTATI'
CTTTTTrCTA
TTAACGCCCC
GCI'ITAATGA
GTTI'GGCGT
AAACTTTATT
TGTTCGCATG
TGAGrITAGT
TGCACCAAAA
TTAAATATTT
TTTATTTCAT
Tur AAGc
TTTTGGAGCT
ACCGCAATCT
GGTvTrrPA
CATCAATAT
ATATTATCCC
I-rrAAAATCG
TCCCTTTXTA
PCT/US 9 6/ 0912a IPENUS 16DEC 1996 GGGGTCTTG QGGTCTTTTTT TTCTATAGTC CCGCATrCC AGrTOGATA 'TAGCCAGCAT GATTTTCAAC CATCAAAGCT CACCCATTGA AGCATTATCG rTI'TCGTTT TITITGCTATC TTTAAT'T-IT 'I GCCACCIT GTTCCAAACC CTAATGTTAA
TCTITITCAA
ATCAAAATTT
rTTTTCCTT
CGCAC
AAACACCATG
ACTCAAACAG
GATTCCTTTT
540 600 660 705 INFORMATION FOR SEQ I0 NO:1086: SEQUENCE CHARACTERISTICS: LENGTH: 831 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vO ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc..feature LOCATION .831 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1086
GAATGTAAAG
'TAAGCTCTT
GGACAAGCCC
GGTCCCCC
CACTCCAAAT
'ITCTTCCAAT
CTTTTCGAT
TTGGATATGG
AACGCTTCTT
GCAGCAAACT
ACTTA'rTGTA
TGGITGAAT
AGAGTGCCGC
TACCArI'TGA
GAATGGAATT
CGT1'GTI'AGC
GTTTGAATAG
CAGGTCTTAC
ACGCTAATGG
TCAAGTCGCT
ACGGGCATGC
TCTCTTGGGG
TTGGTATTIT
ATTGGAAAGA
ACCCTAATGC
'TTGGGGTGAG
TACTCATCAA
AACGGGAT'A
TATGAAAAAG
CGAAGGTGAT
CAATATFI'AT
CGCTAATAAG
GGCTTTGAAT
AGATATGACA
CGATrI'AGGT
TGTGGGGAGC
TGGTGGGGTC
GCAAATCATT
CCCTrATAGC
AGCCAATATC
TAAATTTTTG
TTCGCTTTAT
TTTGTAGCTT
GGTG'ZTTATA
AATACAGGGG
CATAATCCAG
GGTTGGGT
AGCAAGTGGT
AAACAAGTTT
GATTrGrl'AG
GCTATCGGCG
GAAGCCAAAG
ACCAACACT
TACAAGCATA
AGCGCGGGTC
TGGGGTATA
TAGGGCTTC!T
TAGGGACTAA
ATTGCACAGG
GAGGCACCAA
TGAATGTGGG
TTGGTI'TAG
ATGCACCTAA
CTGATATTAT
GTAACACTTG
GTCCTGATGT
CAACCGTCGC!
ATGGCGTGGA
CTAACGCTAC
ACTACACTT
ATCCGCGGTI'
TTATCAGCTT
GAGTGTTGTA
TATCAATTGG
TTATAAGAAA
AGTGTATGGG
TAAAATCCAG
TGATAAAGAC
GAAAAGCTCT
TTGTACCCCT
TTTTCAAGTG
ATTGCGTG
TAACCTrAT
T
120 180 240 300 360 420 480 540 600 660 720 780 831 INFORMATION FOR SEQ I0 NO:1087; SEQUENCE CHARACTERISTICS: LENGTH: 2028 base pairs TYPE: nucleic acid STRANDEDWESS: double TOPOLOGY: circular AiD MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-teature LOCATION .2028 POTus 9 6 /0912 2 79IPEMJ S8DEC 1996 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1087
GCITTCAAG
AGTTG1'G
ACGCCTTTAA
CAAATC PrGM
TTGAACAAAG
TTTAAAAACA
'ZLAAAGAGC
GGGCATCGCT
rI I ITAACTA
TATCTTAACG
GTG'TTIT
ATTAGCGGAG
GGGG7=TIT
CTCATCAACA
GATAAAGAGA
CATGGGGGTG
ACCGCCTTGT
GAAAAGCA?1'
CAAATCCCCT
CTOAprAC
CAAACCA
GATCAAGCCC
GATGAAATCA
AGCCGTTTCA
ATAAA.ATAG
GCTAAATACA
TTGAACATGA
AAGTTAAAAA
AC=AAGTG;
ACAGGCAAAA
AATCACCT=I
GAGCATAAT
GGGGATAAGG
GAAAAAACCC
AA'ITAGAGCC
GTTAGGGAC
ATCAAGGAGC
AAGGCT7rTM
ACCACCAAGA
GCCCCTAA
AAAAGGATTT
TGAAAGCCTC
AGCCCATM'A
AGCAAGAAAA
TATACGATOT
GGGAGAGCCA
ATOTITTAGA
CCCTrAGGAA
CATTA)GCA
AAGTGGTI'T
ATCTCAACGG
rTI'AGAAAT
TAAAACAATI'
AAACCCTITTT
ATCOGGGTGGA
CCATAGGCAA
GGAT=TT!
GC'ITTAATGT
AAATGCACTT
ACCCCCAAAC
GCGTGGAAGA
CGCTrATAGA
GGGGGGAGGC
CCC'ZTTATAT
TACAAGTCTT
TAGACATCAT
GCGGGAAAGT
AAAGCTATAC
TTTGAGTIT
AAAA'ITTAGC
GA TAAAGTrj
CACTI'ATAAM
CGcTCTTr
ACGCCCCTGG
GAGCGATI'AC
AAGTTGAGC
AGAAGTCTAT
AAAGATCGCT
GGGGCTAGGG
AAGGATACGA
CGAGCCTAGC
'TTTACAAAAA
TGCGGATT
TAGCGGGAGC
CACTAAAAAG
TAAAAATGTC
GGTGTGCATT
ACCCACCGCT
GAI'GTAGGG
AACCCCACGA
TGCCGAGCAA.
TAAAGGAGGG
TTTIGCCTGAT
I'rTAGAAATC AGC LrATGAA TCGTGGGCTrA
TCAAAGGATC
'ITTAGATGAG
GCATI'C71rG
CAAAAACGCT
CATTGCOAGC
GGGAAAAT1'r
TCCTTCAATT
TTAGATATrA A'TTrGGT
GGCATTGACA
1TATGGGAATG
AAAGGCATTA
ATGAGCGAPA
GTCCAAGTCG
CA'ITIrT=A GAACCCATr
TATI'TACTT
ATCGCCAGTC
A'1'GGCTrGC
AAGGGGAACA
G71'GTGGATA GTAAAAGATr A=rAGCGCC
AATATCAATA
ACGGGGGTGA
CAAACCCTrT rI'GGAGTATr
AGCAACCCCG
AAAGAAGCTA
CGGTGTGAGA
GTGTTAGTCC
AAGGTGAAAG
TTITTCTA
GGCTATATCA
AAATTGGCTA
CCTACCACCG
GTGGCGTrAG
OACTACATTA
GGCACGCCT
TTAGC'TGG
CCCCTAAAGG
GTAAGA'rTr
ATAACCGCAG
GCGCGCTGM
GCACTGAAAT
TCCAAATCGC
AAACCTGTrc CTGGCTrGAA
ATGATCCCAC
TAAAAGAGAT
TGGGGAGGGA
AAATCGGGAG
ATGAAAAAGA
CGCTCATTGT
TTGGGCCAAA
TATTGCAA
CCAXATGA
ACA7TAAGAA
GCGGGAGCGG
TAAACCATGC
TGGATAAAGT
CCACTTACAC
AAAIAGG
AATGCCAAGG
AATGCGATAG
GCAAATCCAT
AATI'CCCTAA
CTITAGGGCA
AAGAATrGAG GTTI'GCATr
GCAATTICCAT
TAGACATGG
TAGAAGTGGC
AATTGAAA
GGCGTGCGAA
AGATCCTAAC
TA'rACGCT
'I=CAACGAA
CAGC'TrCAT
?I'ATGACATG
?I'CGTGTAAT
AATGGCGGAT
GCATTITAAC
TTTAGAAAGG
TGCGCGAACG
CGGTTI'GACA
CACGCTCAAA
CGTAGAGCAT
GGCTGGAAGG
TAACCA'rrCT
ACCCCCTAAA
7=rAGCGTT
TAAAAGCTCG
TAAAAAAAAT
GATTTATTTA
GGGAGTGATG
CTATAGCACG
CGATCGGGGAT
CTGTAAGGGC
TGCTGATGTG
AATCGCTGTG
AAACGCTACG
TAAAAAAGAC
TGAAGATGTG
GCTAGTGATT
GCCTGATGGG
GCAAAATTGC
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1140 1200 1260 1320 1380 1440 1500 1560 1620 1680 1740 1800 1860 1920 1980 2028 INFORMATION FOR SEQ ID NO:1088: SEQUENCE CHARACTERISTICS: LENGTH: 828 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (gonomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscif eature LOCATION .828 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1088 GCCCGTTTTG TTAAAATCAC AGCGGATTAT TTCCCCTA TGGAAAACGT GTTTTACCGC TCCATTACCA TGACGC1z' ACTCTrGCTT ATCTATCCTI' TCAAACCCTA CCGC =TAAG 120 ATACAAAC AAGGCGG'rTr TAAAAAGCTC GCC'I-I-AGGG TCGTTGTGGG GGGCTTAGCC 180 POT/US 96/091 2 IPENtJS 18ODEC 1996
ATGCTGGCGT
CAATGCGCGC
AGAAGCGCGT
AGCGTGGAAA
TCTTTAGCGT
WTAGCGTI'CG
'TTTATCCA
GGGAITAGCG
GGGATCATCG
?I'AGGCGATA
GGCTI'GCTCA
TTI'rITATAA CTATTrATAC
TAATTTCGC
ATG3TAGGACT
ATATCACTTT
CCITTTGGCAT
CAGGCGTTCA
GGACTAGG
CCCCCATTGA
CATTTTTGGA
TI'GCCTT-GCC
TATIGAAAAA
GcTOCTCCT
ATGCATCGG
AGTI'GAAATC
AA.GGGATTTG
GAGTCTTCTT
TATCCCTAGA
GCAGTATTTC
ATACACCCGC
TCTTAAAAGC
CGCTCTTTTA
ATTTCGCTCG
TCCCCITTTGC
CTAGTGGGG
A'ITATGGGCA
AGGGAATAT
GGATTAGCG3 AAAG5GGATA
TAACCTATG
ATI'GTITTGG
TCTTTAGG03
AAAGAATTA.A
CCACAGCGAA
TITTTGAAAGA
TCOTGT71AT
TATTG~AZCGG
ACGACAAGCA
GCATGTrrCAT
TITTTATGGAT
CTTACATGAA
GGCTATTGTT
TCGCTTTGAT
AAAAAATT
CGCTrI'CTCA
AAAGCTCAAA
TCAGATCCT
GATCTITGTGr
GGCCGTGAT
TGATAr1'CCT
?I'CTITAATA
CGCTCCTGCT
TGGGCTGTAT
CTTATGTTCA
INFORMATION FOR SEQ ID NO:1089: SEQUENCE CHARACTERISTICS: LENGTH: 807 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori ALx) FEATURE: NAME/KEY: misc-feature LOCATION I1.. .807 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1089
GTCATOCAAC
GAAAAAAAA
GTCCTAGCTT
CAC~TTTT
GGCCAAAACG
TT1ATTCTACC
TGACTTACG
CTGGTGTTAA
TKITTAACCC
GTTTCCT
TTAATTGTGA
TTTATAZACA
CC'ITATACGC
CGAGCGGCTG
TAAGCCCCT
CAAGGAGCI'
TGGGGCTGTT
ATAGCGATGC
ATTTGGCITTT
TCATAGGGCG
CTTTATTGCC
GCC~TGGGCT
1TTAGCGCTTG
ACGCTTTAAG
ATACCGCTCT
CTTCTTAGA
TCTATAAAGC
GCTITTCCCT
ACAAAGCGCG
TGATAAGC
GATGAGCGAA
GTGGTGTC
AAGATTGCCT
AAAGAT'rTA
TGGGGTGAAT
TI GAI'IAGC
CGCGTTTA
AAAACGCTAT
TITTTAGTGGG
ACTCATGCTT
CCTI'rTGGAT TTGCcTr CTGTATAtT
GA'ITTAATTT
GAAATCTA
AAAATCGCTC
TTTTTGATCG
AAAAAGCCTA
CTCTTTGCGA
TXTGTATA
GACGGTGCGT
TTTAAGAGCG
GATTAATA
TTGTATTCGC
AAAAAGCCAT
TCCGTTACTT
TTA'rrGTCAT
TCAGCTACAA
AAAAAAGCGT
CTCACGTCAT
AAGACGCTCT
?1'1TACTGGC
?ITAAAACCCA.
TCATCCCGCT
CGATCTTTGC
A.AGGCTTGCC
CCTTAI wr
CGTTACTAGC
TATTTATCCG
GGTT TTIA
TGAAGCGAAA
AGCCATITA
CAACA7TTT
TTGTGGTA
TAAAAGCGTG
AAAAATCCCT
TTTACTAGGG
TTGGTGGI'
TAGCGGGTAT
CCTCTACTAC
CTTTATGGCG
120 180 240 300 360 420 480 540 600 660 720 780 807 INFORMATION FOR SEQ ID NO:1090: SEQUENCE CHARACTERISTICS: LENGTH: 723 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO PUT/US %6/091?2) 1PEANS l18DEC1996 795 (vi) ORrOGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1 .723 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1090 ACCCCI IIlA
AATAGCGATT
ATTTTIAGACA
CTAGCGAGCG
GCCCTI'AAAT
ATITGTATG
CAAA 1TAAAG
GTGAAAAAAT
TGCTTGGTCA
CAAAGTTTCA
AGCGCTCTAA
ACCAAAGAAG,
GAT
TGGATAGAAA
CGC7I"V11r
TAGGCTCAGG
TCATTTAGT
TCCCTAACGC
ATGCGATrT CoGCATGCGAG
GCCTGAAACC
TAGAGAGCT
AAGACAAAAA
AAGITI'GCC
?TTAAACAT
ACTCTTAAGA
ATACGAIr GTGTGGGGTr
GGAAA.AGGAT
TCAAGTGTTT
GTGCAACCCT
GCACCAGAGC
TAAAGGGTAT
AAAAAGCGI'
CGCCCATTG
CCCTrAATC CTATCAAA7I'
TTATACCAGC
TCACGCCCTr
CTAGGCTTGC
AGCAAAATGG
GAGAGCGATT
CCTTTTTATG
GAATTAGACT
TTATTI'I
AAACTCACGC
ATGCTTGGAG
ACGCACAATT
TGSTAACACT'
CCTI'AAACGC
?ITATCAAAAA
TCTGCGCTAG
CG71"IrI'GCTC
ITTTAGATTT
CTTTAGGATC
TCGCTTIC'rIT
GCTATGAAGC
TAGAAACTIT
CGGCTAGGAA
CCAAAAACCA
A'ITCTATCAA
TTATCTITAC
TAGCGGCGCG
AGACAACCCG
CCAAAAAAAC
TAACCCTCCG
TATI'AAATCT
GGTGGCTAAA
CTTGTCGCI'
AGGTTTGTC
TAATTCCAAA
AAGCGACAAC
AGCGCCTTTA
120 180 240 300 360 420 480 540 600 660 720 723 INFORMATION FOR SEQ ID NO:1091: SEQUENCE CHARACTERISTICS: LENGTH: 1287 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE:.
NAME/KEY: misc..feature LOCATION 1287 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1091 TCTCGrCTr
GGCTTGCAAG
CTTTTGGGGC
CCTGTTGTGG
TrTGGCTTGC ATTGGITT 3A
TGCTGGCTG
CTTTITAGGGG
CATGGCACTA
AGCTIGGAAG
GGGCCTGTCG
AAAGACACTT
ATCACTOCAT
ACT'~ITTAT
TTL'GTGGGGG
,\kAGAGGT=r
TAGGGGGCT
AAATTAAATT
GTTATGTGAT
GTGGGI'TrT
AGTTTGATTC
GCGCGGATT
TAGCG=GT'
TCAATCCTTT
GTGCGOCATG
TGGGCATGGC
CTAALATATT
TAGAGGGCGT
CCAG'ITTrGT CGCA'rrTGAT
TTATCTTAAG
CAGTTATAGG
TATTGGAATr AI'rATATrAT
AGACATTTAT
TTCTAAAGTC
AGTCGC'TTr
TTCTTTAAAA
CAAATCTTTA
TGTGGTGTGC
AATGGGGCI'
GGCTAATI'I
GTGCGCGACT
GATTTCTAAA
GGTGTCTAAA
AGAAACTTTA
GCCTAAAAGT
GAACGCTTG
GAATGTGAGC
GTTAAAACTC
AATAAGATAA
GCCACTTTAG
AAGTTTTrM
TI'TATCATGT
GATCCTTTAA
CAAAAAGGCG
CAAAATGCAG
TTAGGQGGAT
TTCACCCAAC
?I'I'GCTrIGG
TACAAACTAG
GGTTTGA
GCTCTCATrG
TTCACCTTAC
TCGTTITTTA
TTGAGCCTGT
GCTGTGCCT
A'TTGAI'AA
TGTGCATGGT
GAGATrATOGA
TAGCGCGTCA
TGCTGACTT
GGAAAATGCT
TOGGGATTTC
CGATCGCTTT
CACCTTATCA
TGAGCGGGGG
AACCTAAAGA
CCCCTAAAGA
CAATAGCITTT
CGACT TTCGT
AAATCCATAG
1711TAGCTTA
TAGCGGI!AT
TAAGGATACA
TI GGTtGTG
TATTCCAGAG
ATTTTATCAT
CTTCATCACC
TGCGGTI'ITr
TATCGCTAGC
AGTGGGTGOG
TTTAGCTCT
GATATTGGA.
CACTAAAGAA
GCAGCGCCTA
A'ZTAGTGGGG
GTGGTGTITG
CGTGTTI GAC
CGCTT'A.ATG
71'rOAGCGTT 120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 POUS 9 6/O091 a 796 IPNUS 16 DEC 1996
CAAGTGGCOG
TAINATGC0G
GCTATGGTOA
GTCGTGCCT
TTITTGCT
TTATGATCCT
CGGTOTTSTOT
ATATOCAAAC
TAGTGGGAGC
TGCCTTT
TTATGTGGTG CTTGTAACCT COCOGGCAT TCCGGTTTTT CATCACCAAC CACTATOGGC G E'TrTTG'T GATATTATTA
CCCTAGT
TAGGGTATG
GGCI'GGACC
CATCGCATGT
ACGCTrI'AGC
CGGGAAGGAT
GACCCCAACG
GGCGTTI'ATC
GATTAAAGC
1.080 1140 1200 1260 1287 INFORMATION FOR SEQ ID NO;1092: SEQUENCE CHARACTERISTICS: LENGTH: 573 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-featur.
LOCATION .573 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1092
AAAITCGTT
GCCCTAGACA
GCCGCTATGG
ATICrrrGTG
GGGCGTTTA
CAAAAAGAAA
GATTAGAAT
GAGCCGTT
ATCCTAGCG
CTATCAGCAT
TGCGTTCAAT
AAAGGGTGCT
CTTI'AGAAAG
GGAGTGGGGA
AAACGCTGGT
GGGCTAAAAA
CATGTGT
TAGATTTrGA
GGATAGAT'C
GGGCGCTATC
TCAAGGATA
TGAAGAATGG
GGCGGTTTTA
TAATGGAGGT
CTTI'OAAATG
AGTAGGGGTA
AGTAGATGC
AAGCCI'ITCT
TAAAGGCAGG
AAGTCATGCT
AAGATGCI'T
CTTTTAAGCG
CAAAACGCT
GATGGCTATA
AAATI'AGCAA
GTCATCAAAG
GTGGTAGGGA
CAAAAAGCAC
GTGGATAAGA
TAC
CAGTGTATGA
AAGACATTT
CTTTGGGCGC
CTCTAGCCAG
AAAGCCCCAT
CATGGGAAGA
GCGCTTTAA
GCTTTAAAAT
GGCGTTAAG
AAAAGGGAAT
AATGGAAAAC
TAAGGTCAT
GCGTWIAGTG
GTGCCAATT
AAAGAATGAA
GGGCGGATrTA
CGCTTGCGAC
GCGGATACGA
INFORMATION FOR SEQ ID NO:1093: SEQUENCE CHARACTERISTICS: LENGTH: 1323 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL. NO (iv) ANTI-SENSE: NO NOi ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc...eature LOCATION .1323 21(xi) SEQUENCE DESCRIPTION: SEQ I0 NO:1093 POT/US 9 6/O091?2 797 1.I iU 19 96
AATGCCCACA
AAAGAATACT
GAATACTrGA
TTATTACA.AT
AAGGGCATGA
GCGCAAT
ITTTCAAACCT
T CATI'GACA
CGGGATAGCT
CTGGCCATI'A
C'1T1TTATA GGGr1TTGG T7I=rAGGG A'T11'AGTI' TrGCr TITrA
?I'AAAACACA
ATCGCTTTAA
ATGTIMTI'CC
CCTTGAGCT
ATGCCTTTAA
rroTrAA
AGCATGGGCT
GGT
ACTTCGAAAGA
CATGGTCTGG
ATCACCAAAA
ACCCTAAAAC
TCTITTACAC
TTGGCAAGAT
ATTCTT TITTC
GCGCCCATIC
TGAATAAAGA
GCGGGTTTCA
CCCCCTTACA
TGTGGGTI'rr
CGTI'ITTAAT
TTAAAC 17 r
GCGTGGGGTT
CTCAAAITI
GCGTGTrAGT
CCTACCAGCT
TGICTTGCA
CCATCCCCAC
CGATTTTAAG
TTTTCTI'GTA
TAAAACCT
GGTTGTTTTA
GCTTSATTIT
GAAAGATCAA
CACCATTAAA
CAAGCCrr'GT
TTTAACGCGA
CAACGCCTTA
CTITAAGAGAC
TZTTAGGGA~
T
1
AAAACGCTAT
TTTGCTGGGG
GGGCTTATI!A
GGTLTTTAGCG
'TTGCTTTCT
'TTAAAGAT
G'TTTGAAC
CTTTAGCATT
TGCGGTGGGT
GATTTCGGT'
CGTGCG-r-r7r
TTGTTGCTAT
CAGGGGGGGT
AGCCTVIGT
TCAAAACCTA
AAAACCTAI'
GAGCCTAA
TCG TCTTAG
AAACAAGAI'
GTGGGTAAT
AGGGCTA6ACG
TICAGCCA
TTCCCTTACA
TATATTGC
GGGTIT7G
TGCTGTATCG
GTTIGTGGGG
TCTTCTTT
ATGCTCATTIG
CC'TIAGGCT
TTAGGGTCTT
TCTICGCCTT
TTTAAGGTT
cAATATATTA TTAAC TCT
TGGCGATTAA
CAAGCTTGIAA
?IGTCTAAA
AAAACCTCCA
AGTCTCTAAA
TCAAATCGCA
TGTATCGAGC
CGCTAGGGAT
GCGTGTAT
GGAACGCTTr
TATAGATTTI
CATCCTT
CCATAGCGTI'
TGTGGTATAT
TCAAGCGATC
TTGCGCATGc TGATrI'ITAC TAT TGGATAA
TATGGCTITTT
ATrI'AAGCAT
TAATGCCTAG
TACGACCCCC
CC'TTATTTA
CGCTCAAATC
ACTCCAATCT
ATACCGCTAT
ATCATGCTTT
TTTrGCGCCAT
GTI'ATTCATA
CAACCACTTA
TCT1'CTCT
TIATGATATA
TITACCCTCT
TGGGGTAAGG
ACTCCCTAAA
C'TTTTrGTrr GTrTCAAGCG
CTTTTTCCCT
TGTGTrrITrC
TATTCTAAGC
GGGGGCGCAT
GAATGTTT TG 120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1140 1200 1260 1320 1323 INFORMATION FOR SEQ ID NO:1094: SEQUENCE CHARACTERISTICS: LENGTH: 906 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL; NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Holicobacter pylori (ix) FEATURE: NAME/KEY: misc...featuro LOCATION .906 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1094
GAGGCGTTTA
GATAAGGCTA
ATTTIATG3AGA
AGGGATAGAA
CATAGTGGG
AGTATCCAAG
TGTGAAAATT
CCAAAGGAT
TATCATAAAG
GAGTTTTAT
AATAAACTAG
AAGGGGGCTA
GTGGCTTTAG
TCTCAAAACT
GGTTTAGAAT
CGACTA
AGGCGGATAC
AAGACTATAT
TCCCAACAGA
AAAACGCTCA
CGGGGTTGT
CG7ITAGAGTG
TCCCTAAAAA
TI'AAGAAGTG
AAGTGTITACA
CGTTATT 3AA
AAATCGCAAG
ATACCCTAAT
CCAAAGCAGG,
ACACGCCT
TTAAGAATCA
GACTATCAGC
AGGGGAATTG
CACTTTrA
CA.AAGGCGAT
GAGCGCTTTA
CGW-ATAACT
GCTCAGCGCG
GCTTGAATTA
AGCCTTAGAA
ATCAGTGGGG
GGATTI'CT
CGCTCATCAA
CAGTGGCGAT
AGACGCCCCC
TTACGCTA
ATGGGCGCTA
AAAGTC-GGGC
CTAGAAAAAA
TACGGGCATG
AGCGCGTA.A
TCTAATA.ACA
TTCGCTCTTG
GCCCCATGCG
AAAGAAGGA
ATCAATATAA
CAAAAATACC
GGGCGGGTTT
GTGTTAGCGG,
ATTAACGCAA
ACGCCCCTAG
TCAAGTCATG
ATTTAGGGGT
GCGAT1'TGAA
CGCATGTCCT
G'TTTGGATC
AGCCTTTAGA
GCATCGGGGTI'
T TTAGATGC
TCI'AACCCC
GCATGCTAGA
CCA.AGGTGGT
TTATCAACAA
GGCTGATGT
GTTTGGCGCA
ATTTGATAGA
cI'ACTAAGC
TTTAATCAA
ACTGCCCTITA
TTTGGGCAAG
?TGGGTGGTG
ATrGG~rr AGAAAATATT1
GGGCGTTTT'
TCACCCTAA
ATrACTAGAC TTrGCTrTTA
TTI'AGGGAGC
AAGCCTACI'
CGCCCTAGCG
AAAGATCAAA
120 180 240 300 360 420 480 600 660 720 780 840 900 906 PCI/Us 9 6/ 0912a 798 IPEI41J 16 J C 199 INFORMATION FOR SEQ ID NO:1095: SEQUENCE CHARACTERISTICS: LENGTH: 1125 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (i)MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .1125 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:109S
CTCGC=IAG
GTCGGrT1A
CCTAGTTTGG
G TrCTAGCA AA=rCTrAG
GAATCGTIAA
CGCI'TGCTCT
TTATGCCAGA
GGCATCAATT
=IAOCGATG
TT-rGAAGTGG AC7L'GCGCGG CCrPTGCCCC
TCTGCCTA
=.LTTITAA
AGCACGGATT
AAGAGTATCA
CCTTTI'AAAAC
AAGGTGATTG
CGTCAAA.AGC
CAGATGA
ATTATATCGT
CT11'AGGGAC
AAGCCTTACA
GCAAAGAI=
ATATI'GCTGA
TTGACAGGTG
CTAGCGTT
CCAGGATTGC
AATTAOCTAG
CGGAGITI
CTATTGGAAA
ACCGCATCGG
AAGATrAA
ATGATACTAG
TCAAAGGGA
TCGCTAAAGA
ATATTCCAGA
GACCGGTIT
AAI'AAAAAC
GGTGAAAATC
?I'CCATGAAA
AAAAGCGI'A
AGAGOCGATA
TGCGTI'CAGG
Gr11ATCT
AACGGACGCC
CACTAA.AATC
ATCTAAT=TA
ATCGCTCACG
CAAACAAGAA
TCAAGGCATT
CAI'AAAAGC
TGATACGCTC
GCGAGTGGAT
TTTAGCCAAA
AGACAGAGAA
CCCAI'GCAA
GATAI'ACCA
CCTCGCIT G
AGCATI'GGAG
TGCTCTTI'GG
AAAAAGGWA
TTCGWCGTIT
CAAATrCAAA AAAAAA?1'GA
AAAGAAAATG-
CAAATCGCGC
CCTTATTTGT
AAACAAGAAA
GAATITGA'rr
GTCATGCTCA
TATTTrCAAC GGCA'rrATCG
ATGCAAGCCC
AAATII'CCT
AAGTGGCTAC
ACACCCCAGC
CGTTTGAAAA
AAGTGATGGC
AAAACAATG
TCCGCCGGCC
CTGTGGATGA
AACTAGTCAA
GAGGGCTI'AA
AAAATrI'AGA
CCCAI'ITTGA
ATCCACCTA
AGAAAATCCT
A'rrGTTGCGT ATTGCAATcC
CCATACATTT
TCCATIrGG CCAT TATTGG
CITTT
CATGCTTGCG
GAGCTI'TGAG
ATTGCCGGT
GATAGGOGGGO
GCTAGGGTTT
CAATCCCAAA
AGTGTTTGAA
ACCAGAAGAG
AXAITTTAGGC
GGTCAGCCCT
AGAAGTGGAC
TGCCCCTAAC
AATCATAGGC
GCATG3CGAGC
AGAAACCGTA
TGAATGTGTG
GGGACAAACC
CACGCCTI'
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1125 INFORMATION FOR SEQ ID NO:1096: SEQUENCE CHARACTERISTICS: LENGTH: 456 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: FA NAME/KEY: misc-feature N~ LOCATION .456 799 l'~U ±dti (xi) SEQUENCE DESCRIPTION: SEQ ID NO:l1096
CGTCCAGTCA
GAAAGCGCGA
AACCAGACCA
AAAGACGCCC
ACGCAAGCGA
GATG7GCAC'I'I CTrI'ATTTAG
ATAGAAGAT'
TTAGCG~ccAA
TCGCTAAAAA
ACCTCAAAAA
CCTTACAA
AGATITTTCCA
CTAAGGGCGG
GAATGGGCGA
TGG77GATIGC
AGAAGGGAGC
TATAGATGAA
CGAGCTTTCT
ATTCCTTATT
TGAGACTI G
AGCGAITTTA
AAAAGAAGAC
GGTGTTTGT G
GATCCAAGCT
GT'=TATAG
AA.AATCGCGC
?I'AGACGC'CA
GCGCTAGATG
AGCGTGCTGT
GATrGATCG
GAACAA
CTCTAGCTTIA
ACACCCCCGG
ACACCTc
CGCAAGCCAG
GCGTrATAT ATGAGT1'I'Q CTI TIGATGA
CAACACCATA
GAGGTTGCAC
TAAAGTTTTA
TI'CTCGCTA
GACTAAGC~r
ATT'ACCCATT
AGAACGC'TrT 120 180 240 300 360 420 456 INFORMATION FOR SEQ ID NO:1097: SEQUENCE CHARACTERISTICS: LENGTH: 693 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1 .693 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1097
AATTTAAGGA
AGGGCTAAAT
CTCAAAGATT
AAAOGCGCTC
CG71IrGGGGT
ATGTCGTGC
ATGTATGATA
TTTG3TAAGTA
GCAAATCTTT
CAGCGGGMA
CATGTATI'AT
TTATA.ACCAT
CAAAAAATAA
ATCAAAATAT
TGAAGTTAAG
ATITCTAA
GGI'IMATIGA
CGATTTTAGG
GGAGTTTACC
GGGAGTTAGC
ACATGAATG2C A'TrACAI'r
GTGATGAAAA
TAAAACGAT
AGTCAGGGAT
TTTIA=rTAT
ACAAAAAAAT
AGAGGGTI'T
CCCGAGT
AATCGATACA
CCAATIATTC
GCTGGCTAAT
TCGTATCGT'
CATTAGAAGT
AGATCTATTA
TTTAGAGATT
AAAT TGGCT'
AGCCCATI'AG
AACCGCGTGT
ACTATCGCGC
TCGCGCTAT
AGCTrI'AGGC
AAAAAGCAAC
OGTA 'CTrA
ATGAAGAATA
CTrGGTAGCG
CC
TTTGTAAAOA
GCAAGCTITT
GGCATr.AGCT
GGTTIGCCTAA
CC1TTTAGGTT
ATAAGCGGGA
GCGTCGI'I
TAAAACGCCC
CAGACGCCTA
ATAAAAGGAA
TGITI!CATCA
ACGCTTGAAA
GTTTTGGA
TGACATTAGG
AAGCATCAAA
GCCATTAAGG
ATT'GGATTGT
TGGGCTAGGC
CTTAGTCATA
TGACATTGAA
ACATTATOAG
CCGCTCTAAT
INFORMATION FOR SEQ ID NO:1098: SEQUENCE CHARACTERISTICS: LENGTH: 600 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genornic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: Nzz AMENDED SHEE4- PCT/US 96/091-22 900 ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .600 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1098
AGAATAATAA
GTAGCGTGTT
AGAGGGCAAG
AAATCTTCG
CAATATGAAA
AAGCXTIAG
GAAAAAAAAG
AAACAGCGCG
ATGGCTTATA
GAAGCGCAAA
AAGGAAACAT
TGATCACCGC
CCAITAAA
TGGAAGCTGA
ATAAGAATT
AAGCOCAGCA
AGCTTGAAAA
CCA'T'GTA.A
CCAAAGATGA
AGAGCGCCTT
TAT GAGCAGC
TCTAATCATIG
AGGCGCTTCA
AGAAATGCGC
GCAACTCCAA
CAAAGAATTTI
AGAACGCCAA
AGAAGCTCAA
AATAAAAGC
GATCAGGCOT
GGGTrAAI-r
TATI'ATGTGA
GCCAAAGCTA
ATGAAAAGCC
ACCCATIT=
GTAAGAGATG
ATTTTAGAAC
GCCAAAGCGC
ATGATCTTAG
TATGAAGAAG
ACATITTCATI!
TGAAAAAGAT
AATTAATGGA.
AAGAATGCAA.
ATAAAAAAGA
AAAAACGCTA
AAOAGAGGGA
TAGATGCGAT
AGCAATTAGA
AAGCCTTTAT
AGAAGTCTTG
CTAI'ACGCT
XITTTCAAGCG
GTTGCAACAG
AGCGCATITM
TTGGAAAAG
AAATTTAA
GCTCAATTAC
ACAGGAACTA.
TATGTGTr'rA INFORMATION FOR SEQ ID NO:1099: SEQUENCE CHARACTERISTICS: LENGTH: 1050 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-featur* LOCATION .1050 (xi) SEQUENCE DESCRIPTION: SEQ ID N0:1099
ATAAGGTCAT
CCAAAACCCA
AAGCATGCGC
A?1'CCTAAAA
ATCCCTAAMA
GCAGAAAATG
ACCAAGCGCA
GGGGCGATGA
TTGCATAAAG
TACATTGATT'
TCAGTGCATG
TATrTTrTAT
GACGATGTOGA
CAGCGATTGA
GTCCGCAAAA
TTAGCCGGGG
GAATCTAAAC
GGCATTGATA
CAAATGACAC
CCCCTAAACC
ATTCAAAGCA
AAGAAATCCC
AAGAAATCCC
AGAGTAAGAA
AAAAACACAA
GCGCGAATT
AGCTI'AAAAA
TAGTGGCCCG
CCAATI'CCAT
CCACCGCAAG
ATI'TAATOGA
TCGTCTCCAA
ATTACCCTGA
C'IITAATGCC
GCATCCAAAG
GTTTICTI'CAG
CCAAACCACC
CATrAAAAAA
TGCGCACTCT
TAAAAAAGAA
TAAAAA.AGAA
CCAAATCTT
AAAOATCG7I'
GGTGTGTGAA
AAGAGGCTAT
AACGGAATTA
CCCTAAACGC
GAGTGAAAGG
CTATTTTrCT
CAAATTAGCG
TGTGGTGGAT
TTCAATTTTA
CAAACCGTAT
CAAGAATGAT
CAAACACCAT
GAGGCTAAA6A
CCATI'GAACG
ATCCCTAA.AA
ATCCCTAAAA
ATAGCAGAAA
T GGACGCTG
AAGGACATL'O
AGCGTTAT
GCCAATAAAA
TCCACCTCTA
GCTAGGAAAG
AAAAGTITTGT
ATGACGTGC
GGGGGGTTA
ATAGAAATTG
CAAAAAATCT
GGCACTCAAA
AGGCTAAAGA
AAAGGAGCGC
AAGAAATCCC
AAGAAATCCC
AAAATGATAC
GGCATrGOGGG
TTTWITAGAAGT
TGACAMGGGA
AAGGGGCGGA
ACGCCCATCG
TGGCTOAGCA
AATACGGCAT
GGGAGGGGCC
GTTATAA'rIC
TGGCTAAGGG
CACCAGACGG
GAAAACAACT
TAAAAAAGAA
TAAAAAAGAA
TAAAAAAGAA
TTGGATCAAA
GAAAGATIC
GGTGAAGTrr TAAOOACATr
~TTTATTCATC
CATAGAGACT
AGAAAATAAA
ATTGAACACG
GCTCCAAAGT
TTTTGGGTG
CCATGCGATA
CATTGCTGAT
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1050 PCTIIS o 9OI2 I PEAIUS w U v i -I 801 SEQUENCE CHARACTERISTICS: LENGTH: 558 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE:.
NAME/KEY: misc-feature LOCATION .558 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1100
AGAGTATCTA
GATTGTTTGG
ACCATIGGTC
GGTGGGGTGA
TTAGCGCGTC
GAGATGTATC
TTCTTTAATG
GCTATAGCAG
AAGCAAGAGT
TGAATGTCAA
AGAAACTI'G
AATTAGCGAT
TGAGTAAAAC
AAAGGCGTAT
AAAATCAAT'
AAAGTTTTGA
TCAATAACAA
GCTGGGAATr
AAAAAAGGGA
GAAAGAAAAC
CCC CATI'CCT 7TTITATGAT
TGAGATTGAA
TAATGAAGTG
TGAGCTCGAG
GATCCAAGAG
TATCACTAGC
AAGCCACAAA GTGGAAAGAT ACTACTTTT TAAGCAGTAT GGAGTGGAG TGCTCATrGG GTCTCGCTAA CGATITI'CAA AAAGAATGCC GTGAGAGTAT TIT GAGCGGT AT'TrCATG AGGGCGCTTI' GT'GCGGGCGA GGGATGGGTC AAGAGTTGCT CGTAAAGAGG GTIGGAATI'I
TGATAGGGTG
AGCTATGGGG
GGGCT'TGTG
AGAGGCTAAA
CAGACAGTTA
GACTATAAAA
TGCGGATIWIG
GT'ITGACAAT
CGTCACTAGC
120 180 240 300 360 420 480 540 558 CGTGGAAAAA. CAGAAATT INFORMATION FOR SEQ ID SEQUENCE CHARACTERISTICS: LENGTH: 1086 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-.feature LOCATION .1086 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:11 AGAAGAAAAG ACCGAACTCC CTAGCGCGAA AAAAATCCAA AAGAGGGATC AAATGGCCGA AAAGCCAGAG AAGAAGGCAA TTGGCTGGGC TAATGAGTAT ATGTATCGCC ATGTGTTGAA CTGTTTAACC AGCTGGCTAA ATGGTGGTGG CGI'TTTGTC ATTGAGCCTA AATTTTCTAA AAAAAGATCC TTGATGGGAG TTITTCATCT TTTCCTTATT
TGGTGGGGT~
TGTGCCTAAA
TTrTGTI AGA TTTCTCC
AGACACTT
TAATGTCT'G
AATCAACCCT
TTTGATCACT
AGCATGGAAG
TTTATATGGT
CTAGATTTTA
TTATTGCTTTI
CAATTTGGCT
ATCAATGGCG
TTAAAAGTTT
GGGTGGATGG
GCAAAGAAAG
TGCCTGTTTI
GGCTCTTTGC
TCAAAAACCT
TTTTAGCT'1T CGGCTC ri"T
CTTI'AGCGAG
CGTTCAAGAG
AATCATTTTA
CCCTAAAGTC
TT TCTTTA
TTTCTGGGG
GAAT11.CAA 120 180 240 300 360 420 480 540 TI'AGGGGAA TTMAACCATG A~ PCT/US 96/0912a2 IPENUJS i 8 D E C1996 GGCCAGT1'GT TlwrIWITGTcT
AAAATGACTA
A.AAGCCAAAA
cccAAATCCA
GAAGAACACC
AAGGGTATCG
CTTTATAGAG
ATI'GTCTI'CG
CCTCTI'
TGTGGTTTAA
t GGCTI'GT
AACAAGAAGT
TCCCCAGAT
ATGTCGTGGT
CTGTGCCTGT
CCAGAGAGCA
ACGTGAAATI'
CTCAAGTGGC
AAGcAAGGCG TTATGGCTCA GGATZ'IAATC ATCAAACGCC TAAGGACGAA TACAAACAGC GATGGTAAAA AACGCCACGA GACTAACCCT ACCCATTATG GGTAGTGGCT AAAGGCACGG TGACATAGAA ATTATAGAAA GAACGCCACC ATACCAGAAG; TAAATTAGAG CAAGAACGCC TTI'CTrCGCT
GCCAATACAC
AAGAAGGAAA
ATAAAATGAT
CCGTCGCTCT
ATAT'TAGC
ATAAAACGCT
AATTGTI'TGA
AAA.AACAAAA
TTATITIA
TAACTCTA
CCCAGAAATC
GCAAGAAATC
CAAA'rrrGAT CATITAGGATT1
CGCTAGAGAG
AGCGGTAGCG
GATCATTAAA
600 660 720 780 840 900 960 1020 1080 1086 INFORMATION FOR SEQ ID NO:1102: SEQUENCE CHARACTERISTICS: LENGTH: 543 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .543 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1102
GAAAATACTA
GACAGATTAG
'TCATCACGC
TTAACCCAAA
AACGAACAAA
TTAGGGGCAG
AGAGCGTATC
AAAAAACGCC
ATTAGAAATC
CAA
TGCAAGAI'T
ATACTTATGA
CTAAAATCTC
1-AAGGGGAG
AAGAAAAGAA
TGGTTAGGCT
GT'I GAGAGC
TTCTTTACAA
GCACGTATCA
ACAACA'TITC
CAGCCTAGAG
TAACTTAGAG
CGAATGGGTG
AAAAGAAATC
TAT'IIrT
TTATTATCAC
TTATATTAAA
TI'GGGAAAAT
AAAAhATGATA
CAATACAAAG
ATI'IATTTAC
TTAATGAA
ACGCATTCTI'
TATAAGTTAG
GAAAATAAAG
GCCCATAT'G
TTACTCAAAA
TTACGCTCAT
AAAMTAAA
GCAACGCTI'D
ATTCTTTAAC
TAATCTX!ATC
AGGGGGTAAT
ATACC1'YGCT
CTTTAAACTT
TCCAACCGAA
TCT7MTAAA
ACTCAZ'ITCT
AGACTATGC
AGATT1TAATT
TAAAATGTCT
ATTAGATTG
TATTAAAGGC
GCTATGGACA
CAACCGCCCA
120 180 240 300 360 420 480 540 543 INFORMATION FOR SEQ ID NO:1103: SEQUENCE CHARACTERISTICS: LENGTH: 567 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: No (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: Al,! I PCTUS 9 6/ 0912? IPENIUS 18 DE C 1996 803 NAME/KEY: misc..feature (al) LOCATION .567 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1103
GCTAATGGAT
AAAAAAGCGG
TGCCTrAAAA
CCAGAAACGG
TI'TAGCCA TT
CAGGCTCI'T
TITTGCTAAAA
?I'AAGCGTGG
GTAGGGCTIA
GAAAACATCA
GCGAAAAAAG
TGCCTATTGG
ACCCTGATAC
AGATTTTGAG
TAAACAGCTA
TT'GAAAGGGT
AAATGGTTCA
CTAAATTr
ACGCGCATAA
TTGATAGTT
GATI'CATG
TGTGGGCTTG
AGAAAGCCTT
CGTG TTGAA
CACGCCTITG
GCGTGTGAAT
AAAGGGCGT'
TTCTTTAAAG
GGAATITTAAA
GATAGTT
CTGCTTTGCG
ATAGAGAGCG
ATITATAG
ACCAI'GAAG
GATAATTTCA
AGCAGTAACT
TTATAGAAA
GCTA&AGGGA
GAAAACCACG
CGGGAAOGAA
CGATCAA'IT
GGAGCGCGGG
GCTATCAAAT
TTCACATAGA
ACATCCACAC
ACATGGAGT'r 7'17IT~GCGT
CCAAAGTCAA
TGAGACrTTTA
AACCAGAATG
GAGTTATAGC
TGAAGAGAGT
AACTAAAGAG
CAGCGAAATG
TTTAGCGTC
GAGCAATCAT
ACAGATTCTA
120 180 240 300 360 420 480 540 567 INFORMATION FOR SEQ ID NO:1104: SEQUENCE CHARACTERISTICS: LENGTH: 1018 base pairs TYPE: nucleic acid iC) STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc...feature LOCATION .1018 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1104 TI'TIAATGAG TrITrATAAGC AGAAI'rGTG GATICCTA GGAGTWIGGT TTTGTGGTTA CATI'ATTGCT GTTGAAA.ATG ACAAAGCCAT TI'ACCCACTC GCAArTTTAAC AACCAAGCGT AGCOACTAAC ACCGATATrA GTTTGACCCA AAAATCGCTA ?IATATTGTA ACCACCAACA
TTGCAATCGC
AAAAAATCAT
CTCAACTI'TC
GCGTCGCAAC
CAAGAATGGT
TTGATCGC
ATTTCATTAG
ATrrAAGGAA
CGCTCAATAT
GCGGCCTTAC
CGCTAGGGAA
TAGTGAAAAA
CTAGAGAAAA
AAGGCACAGA
TTGACGCTAA
AAAAGGCTAT
TTGAAGAAAG
CTCTTGGCAA
CCGT1T1TCCG
AGATITATGAA
GGCTAAAT1'C
CGCTAAAAAA
TCCTAATGAT
CTCTGATG
AGCGTGCAAT
?1'TAAGTTGT
TAAAACTTCC
ACTI-rTrTCA
AGAAA).ACGA
TAAACGAGAA
AAACGCTCCC
AGAAGAAAGG
GGAATTTGAA
AAGAAAAGCT
GAACCCTTAA
GCCCATG3ATT
ATCGTITAATI'
AAAGCGTTTG
GGGGATTTAG
GAACTCTATG
TTGGTTACTT
GTI'TATAGCG
GAGAGTTTTG
ACGCCGTITT
GGCAGTCA.AT
AAAGAAGTAA
ATCAAGCAAG
ACI'TAGAAG
CGTCGTTCA.A
CAAAGAGCGA
TTAGAAATGA
GAGT1GAGTAT
TGAAAGTGGG
CTGAAGTGGT
AGTCGATGAA
TCTATTTCAG
AGCAAATCAG
TITTGAATGG
TGGGGGTGAT
AAATrI'rAGA TTrCTAGGGT
CTAAAAATTA
GGATT1GAAAA
AAGCCATTAA
AGAAAAACTA
GAGATGAAAG
GAGAACATCA
ATAAGAAG
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1018
AAAAAGAGAG
TGAGGGCATT
CTI'CGCTI'AC
GMAAGAAGAA
AGAGCCTAAA
CCAAAAAGCA
GAAAAAAACT
AGAAAGAGAT
CTGGATACAA
GATI2CAGGCA
TATGACGCTTI
AGGATTGATG
AAAGCCAATC
GAGCGAAAAT
AAAGCCACCA
GAAAAAGAGC
INFORMATION FOR SEQ ID NO:1105: SEQUENCE CHARACTERISTICS: LENGTH: 852 base pairs TYPE: nucleic acid STRANDEDNESS: double PcTUs 96/091?"f.
HAW~tS 18OEG1.996 804 TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION .852 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1105
GGAGAAACAA
ATTTTAAGTG
ACGCCTGTGT
AAAGACACAC
AATAAACAAG
GGCGATGCCA
GACATrIGATT
AACTACAATG
AGTCAGCCAA
AACAACAAGC
CAGTATTACA
CAACCAGAAA
ATI'AGTTCTG
AGGGAGAAGC
CTCAGTGGTA
CAATGAAACT
CGTGCAGTAA,
ATAATGAACT
CATICATGGT
TI'GTACTAAC
ATAAGATCCT
TFITACTTGCA
ATAATCCCAA
TGCTAGGAGC
AAGTGATCAA
AGACTCTCTT
TITTAGAAAC
AGA'TTTTAA
TACAAGAAGA
AG
GAGAGCAAGT
CTATGCGAAA
GATAGAGAAG
GCAAGT(;AAG
T1'TCAAACTT
CCAATACAAG
ACCCACI'TG
CAACAAAGAA
TAACACAAAA
TGAAGTGGCA
GCAAGACAAG
ATTIGAGTAAT
GAATOGGCAAC
AAGAGAGAAT
GTTI'AATCG
AAAGTGGTGA
TATAGTGAGA
TrGCCAAATT
GTCACCAT'
AAT'rACTI'CC
AATCAAGG
AAACCACAGA.
AACTTGCATOG
AGAGAAAAAG
GAACAAGAAT
CGTGCAGGTT
TTGAACATGC
GAATACTTIC
GTGTGGCAAT
AACAAAAGAA
TCCCCTI'AAA
ACAAGGACTA
CTAAAAAGAT
AAGCTAACGG
GTGTGGTGAT
CCTTTGATGT
GCTATGATGT
CTCAGCTAGA
ATACCACTAG
ATCAAATGAG
AAGCCAAAGA
GCAATCAAAT
TCTGTGCTTA
CCATGTTrAT
TGACAAACTC
TT''TGTGGAT
TACGCTCATA
GGCAAGATCT
GATAGCGAGT
GTITGCAAGGA
GAGTGGAGCA
AAAAATCAAT
GAAAAATAAC
GCAGAATGTG
AGAAGAAGI'
CAGAAGTTG
INFORMATION FOR SEQ ID NO:1106: SEQUENCE CHARACTERISTICS: LENGTH: 723 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-.feature LOCATION I1.. .723 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1106
AGTI'ATTGTC
GTTGATGG
ACCAACCAAC
AATAATAAAA
GGAGATITAG
GATGTGATT
AATCCCTI'AG
CTrI'ATTGTG
AAATGAAAAC
CAGAAGATAT
AAGTGCTCAA.
TAGGTCAAGA
CGTTAT1TGAA TTAAGACTrA
ACCAAAAGAC
AGGGGAAGCT
ACTCGTGAAA
AACAAGCGGC
AAACCTAGAT
AGATGCTCTA
AGCCAATT
TATGTCTAGC
TCCTGAGCAA
GAAAATCGAG
AATACCATAT
TTAAAGCAAC
GAGATTTTTI
AACATCAAAA
GAAGCGAATG
CCTGAACTTT
CAATGCGGAA.
CAAGAAAAAC
ATI'CTrITrl'
TGGATAACAC
CAACCACTAG
AAGCGGCCAT
AGTTATTT
TATTAACCTA
TATCCGATAA
AAAATATAAG
GCTATTGTCT
CTACCAAGAG
CCCTAGCGCT
TGCTTTGAGA
CATCTCAGAA
TATGAAAATC
AGTTI'AGI
AGAGCGTTTA
120 180 240 300 360 420 480 PCTUS 96/O912 IPEWiVS i 8 DE c199-0 GAAACT1'CTC TAAAGGCATA TCAGAGCAAC ATTGGAGGTA TCACAGACGC TTGTAGAAAG CCTAAAAA.AT AAAAI~rTCA ATGTrAGCTC ACA.ACAACGT C~qrTTAAAT TATTTAGAGG TCCCTAGAAC AAAGTAAGCG ACAATACCTA CAAGAAAGGC
AA
CAGCTTCCT1'
TCAAAGGAAT
AGTTGGACGC
AATCAAGTAA
AATCACTGCT
CAAAAAGCI'
ATTAGAAAGA
GATCATIGTI'
INFORMATION FOR SEQ ID NO:1107: SEQUENCE CHARACTERISTICS: LENGTH: 1617 base pairs TYPE: nucleic acid STRANDEDNESS; double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .1617 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1107
ATAAATAAGA
CTCATTGIC
TACCAAACAG
GATATTTTGA
GGTGTGATCG
AAATATTTGA
ATACAAGGTI
AATAAAAACA
AArTrACCA
GGCTCAATAA
GGTAAAGAAT
GCATI'AGAAT
AATCTGCCTG
TATATTGT'D
GGCATTCAGA
ATGGCGATWQ
TCTATTATT
GATITTAGTGC
AATGTTGGCh TZTCGCTATTT1
TGATAGCGG
GATTGGTTCA
TGGT'CTAG
ACCATAACGC
ACTA?1TGCGA
ACCGTCAATG
GATAGAGAAA
ACATGTTTAA
CTAATTGGTT
TITATTGCAT
CAGGCTATAC
AAGCGCTTAG
ATACTI'AGG
?I'GCTCTAAC
TAGATGTATC
AAGGCGGTGT
CCGCTCAAGC
TCACTGCAAA
TATAAALGG
GAAAGCTATT
GCTGATACCG
ATCTATI'OGT
CACACCATTA
TCCTI TATGG
GCCATCAAGT
CATGGATAGC
TGAGGACAAT
TTCTACGAAT
TAAACTGCAA
CTG.TTGTCAA AGGACGAC 'ATATI'ATCAT AGGGCAAGG ACTIT~rAA
GATITGCCCA
AGTATGTT
GCATCAGGGA
GCCACAAG?1'
GGATCGGCGT
GGCTGTAATT
GTACTAGACA
GTGAAAGGCA
AI'ACAGCTG
AACAACACTA
GCTGCTG'1'IC
TCATATCTG
TCTITTATGA
ATGCGA~TTTO
GGmTTGGTT
GGGCTGAATC
ATITTACCTG
CAAGGCTTGC
ATGAGAATAA
TTCCCTATX
TTG2ATATGG1 GGTGTrI'EGC
ATCAATCAAC
TTAAAAGGTI
AGCTCTGTC1
T'I'GGGATTT
TTAACATAGG
TC TTTTAT
TTGGTTTAGC
TCAATTACAC
ACAACGCTCC
TITATGCAAGT
GGGCTTAG
AAGATTCTAT
CTATTCCTAT
CCTCTGTI'GC
GTTTGATCAC
CGATCGT'AA
GAGATGCCTT
TGTTTTTATT
TTITGAATAC
CGCCTATGCA
AGGTGCTT
TGTTAATTCA
TAGI'TGTTA
AACTATCATT
CGGTATTT
GAAAAACATA
TTGCTCTTr
TATACAAAAC
TCTATTTAT'
CACCATTTTC
TAACGATCAT
TrGTrI'CAAA
TAACCAACAA
GTGGAAAGAG
TAGCCGCTAG
GGGCAAGTGT
TTGGTTGGAA
ATTTGAGCAA
ATATTCTI'I'
ATGGTTTAAT
TAGCCATGCT
TTCCTGCATA
ATrI'rGTIrC
AATTGAGAGA
TrOGGGOGGAC
ATCTTTATAA
AAGTTCTI'IT
CGGTAAGAGC
AAGTGGCAGG
GCACTGTrT
ICAGTATGTTT
TrATTAATAA CATTA'I GGC ,JGA.Jrn..
7TCATAGAGAC
CTATGGATGG
GATCTATGTI
AAGTlrrrrvI
TCTCAAAAT'
AAGTI'TGCA
TTCAGGGCAG
CAATCTGGTG
TGCTACAGCT
CGCATTGATA
CAAGATTCAG
ACAAATAATr ,rrGGCTGATr TGCTTrrOCC
TGGTGTAGT
TITACCTAATT
TATTTCAAAC
ATTATTCAAA
AATCTCTI!AT
TI'GGGCTI'A
TGTI'TI'TCT
TATI'rCITA
TGTGAAACCT
GATCGTGCTA
TCTGT'rrATC
ATTCAATTTG
TATCGATTCA
GATTATTOAG
TAGCAGAATG
TAAAGGA
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1140 1200 1260 1320 1380 1440 1500 1560 1617 AATGGTGGGA AGAGTI'GGT( INFORMATION FOR SEQ ID NO:1108: SEQUENCE CHARACTERISTICS: LENGTH: 768 base pairs TYPE: nucleic acid STRANDEDNESS: double OrT4' 9,c/09122 IP ULU 1~o 99-6 806 TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .768 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1108
CTCCATAGAA
AAAGCCTIGT
CTAACAGTCA
7TAAAAAAGA
ACCACAGCCT
AAAATAAGAG
TATGTOCATA
CCTGAAAAAC
TATITTIGGTT
AAA'I GAGCA
TATAGAGTTA
GTGATCAATA
GGTGAATTGG
TTATCTCCTG
ATCAAT1'CAT
AATTAGAATA
GAGAAGAAGC
ACATCAATAG
AAGAAAAACA
AT-GCGTI!AAA
GCTCTAAACA
TCAAAAACAT
TGACTGATGC
ATGAAATITGC
AAGGCTATGG
AGCGTGTGAT
COATAGCOCT
TTrGAGGATA
CCCACAAAGA
AAAGAGGCAG
AGTAATGATIG
AAAAATTATA
AAGAAACCCT
TATTATGCCC
CACTCTCCAA
CGCCATTGAT
AGAGAAGTIT
GAAAAATCCA
TAAAAAGCTC
TGGAGGACTA
GCCCAAAAAG
CACGAAGTCT
AGAGAATTGA
GCGAGCAATG
CTAGATCAAG
GTGCCTAGAA
TCTGAAAT1T
CCTGCTATI'
CCTAACATIGA
AAGCTCATI'A
TrGACAAAAA
CCTCTTGTCA
ATCTrIGTrrGT ACAATITI GC
CTAGCGI'TAT
TCAAGCAAGA
AACAGATTAT
CAAAGGCGCT
ACTACAATITA
TTGATIGATGG
TrrGTGGTTCA
CTAATTCAGG
AAdACAAAGC
ATTACAATAT
GAGATAAA
GCGGACCAAT
TrCAGCGTAT
TGAAGAGGAA
AAATCTCAAC
CAACAAAGAA
AGAGACCCAA
CTACCAAGCG
CACATTCACT
ACCTGATGGG
ATTGAGATG
CCTTGTAACA
CAAAAACTAT
120 180 240 300 360 420 480 540 600 660 72a 768 INFORMATION FOR SEQ ID NO:1109: SEQUENCE CHARACTERISTICS: LENGTH: 363 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genoinic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc...feature LOCATION 1 .363 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1109
ACTAGTTCT'I
CAATI'CAAAC
AATATCAGCT
All I rAGTTT
TACACTACTT
AGCCACGCAA
TTA
TCAAAACCAA
ATrCI'rCAA
CTATCGTTAT
ATCCAATAT'
ATCTTIOCT
AT1-rCACAAT
AATGA.AACGA
CAAACATZ'rA
ATTC?'GTT
ACTCGTTI'CT
GAAGCTAATC
CCGATCAGCA
GATAAGTACA
ATAGCGCT
GCTCTTATAA
CTCAGCATAA
ATGCTTATGA.
AATTGAAACA
GCCTTTATTA
TTTCTTATGG
TAAAACCTAG
TAAGCAAATA.
CTCAATGGCA
AAACTmTA
TAGGCTGTTC
GGCAGGGCTG
C TTTTTAT
CTATCTCCTA
AAATr'GGTTC 120 180 240 300 360 363 INFORM4ATION FOR SEQ ID NO:l110: 091 irEAtUS Id i J 807 SEQUENCE CHARACTERISTICS: LENGTH: 393 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .393 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:lllO
GTATGCTATI'
CTI'ACACAAC
GGCGGAACAA
TI'GT'rCTTCC
CCTATGGACA
AAAAACATGG
ACTAATAAA
GTGAAATGCT
CAAAAATAAA
ATCTT1'AC
TGATGTI'AAT
ATATCAAGAA
GATCTGCTI
TGAGTGTCCC
TCCTACTAAA
AGGATTGAGT
AGGTTTIATCC
GATGGGAC'T
TTITATGGCA
GGTTGGTAAT
ACAAGTAAGA
ACACGCATTA
ATGGGAAAAA
AGTGATTGT
AATGAAGCAT
GAAGTGCTGA
GGTITTIGGTA
CTC
GAGATCCGAA
TTTTAGCTC
TTTCTATGAT
TAGGGAAAAA
AGAATOGATT
GCAGCAAATC
CAAGCAAGAA
TI'TGTI'GGGT
ATTAAATTTT
ATTAACTTG
CGATAGTATC
AGACAAAACC
INFORMATION FOR SEQ ID NO:1111: SEQUENCE CHARACTERISTICS: LENGTH: 892. base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE.
NAME/KEY: misc-feature LOCATION .891 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1111
GAGGAATTGT
TATrI'A'rIT
GGTAGGGTGA
AI'TGGACTT
TACATCACAA
ATTCAACCTA
CTAATGACAA
GACCCTAAAG
CAGGCGCAAA
AGAGCCAATT
AAAAATCTTA
TOATGGGGCA
TATCTAGCGC
AAGTG;GTGAA
CATTAGACAA
CAGGTCAA
AATCGGTAAA
GAGATTACCA
AATAGAAGA
AGGCACAAAA
TAGAAAATCT
GCGAAI'GAT
GGCATrTI'TT AAAAAAAT'G AATAGAAGCA GTAGCACTTG
TAAGAAGATT
TGTI'ACCGTG
TAAAGGTTGG
AAGTAATCTC
AGAATTTIA
ACAAAAAAA
AGATAAAAGA
CACTAACGCT
CAAGCAACAG
GCTTATTGG
ATCCAACTTIG
AGTATTGTGC
ATGTrGAAA
AAGACAAAAA
GCTCTAGAAA
GAAAAAAGAA
ATGAGTAACC
AGAGAAAkATG TTGGCTGT~r ACATrAAGAA
GAGATGAAAPL
AAAAAGATGA6
CTAATTCTAA
AAGAAGCAGT
AACTITATCGT
AAGAAAAAGA
AGGAGGAC
CACAAA.AT
AATTAGACCA
CTGTCTTGGT
'TTTTAATCGT
ACCTATTACG
AACTA2'1TCT TCATATAT'rC
GAATI'ITGCC
AGATGCGCCT
AGCTAAAGAA
TGCAAAAAAT
GAGCAATAAC
AATGGAACGA
120 180 240 300 360 420 480 540 600 660 PUS C96 u91k IHEA/IS i21996 CTAGAGGACA TOCAAGAGCA GGCTCAAGCT AACGCACTCA AAGAAACAAG CTGAAGAGGC AGTI'AGGCAA AGAGCCAAGG GATAAATCTC AAAAAAGCCC CGAGGATAAC TCCATAGAAT GGAC'OACTAA TCTIGTTGTG CGGACCAATA AAGCCTIGTA
AACAAATI'GA
ATAAAATCAG
TATCTCCTGC
TCAATTCA'rr
AGAGCTCAAC
TATTAAGACA
GATAGCGCTI'
T
INFORMATION FOR SEQ ID NO:1112: SEQUENCE CHARACTERISTICS: LENGTH: 765 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .765 (xi) SEQUENCE DESCRIPTION: SEQ IV NO:1112
AGCTGTCGCA
GGTGTGATAG
GCTTTATC
CCTTI'GAAGA
ATCGTCAAAC
ACTTCAAAAT
GATCAACTAA
GAAAATATCA
CAAAGAGAAA
ATCACGCCTG
TATGAT=r
AAAGTGTI'G
AGAAAGATI'A
TGTTAGGGAA
CCCTI'GATAG
TCTCTATGGT
AAACAGATAT
GCTCCGATGC
?I'GTCTCATT
TGCAGTATI'G
GACAATI'CGT
AAGTCAAAAA
ATACAATGGA
CTAGAGGTAA
ACATTCAAAT
AAGAAGTGGA
AAAAAACGAA
AI'GGCAAAA
GCTCAATGTC
ATTI'GTTTAT
TAGGCAAATC
GCTGTTGGT
CGATGTGAGT
AGATAAAGTC
TAGTCCCTTA
AAATTATGAA
CTCTTCTCAA
CACGGATTTA
ATCAAAAAAT
GAAGTCTTGA
CTCAATAAGG
GCCGCTGTAA
GGCATTGATC
GTCAATI'CTG
TATAGCAAAA
TTCCAAACCC
CGAGCAGAAG
ACGAGATI'AA
TATATCACTA
GAAAATCI'A
CAAAACGAAC
TTGATGAAAA
CCAATAGGAC
CGAGTATT
GATACACAGG
AAGCCGTTGT
ATTCTTTGAG
AAGCAATGAG
CTATCATTAG
CATI'ITrCAT
AAAAACAAGT
TCATCAACCC
AGACAGTAAG
TTTGGTTGG6
TTTCAAAAGG
GATGATGATG
AGAATTrAAA
GGATAGTGCA
GGATCGCAAG
AATGT17CAAT
CTCCAACATA
TACCATCAAA
AACTATAT
TTTTGGCTTC
CGAAATIIG
120 180 240 300 360 420 480 540 600 660 720 765 AAGGCATI!AA ATAAA INFORMATION FOR SEQ ID NO:1113: Ci) SEQUENCE CHARACTERISTICS: LENGTH: 750 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature X LOCATION .750 PEs.4LS z) 09 809 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:lll3
AAGCGCCTAA
AAACAATrTC
GGATCCAATC
TI'GCTAGACT
AAGAATCAAG
AGGTATGAAC
CATTCATTCT
ATAI'rGTTT
GTGGAAAGTC
GCGGTTTTGT
ATTGGTAGCA
GGCTA?1'TGA
TTCGCTTCAA
TI'CAAAGAGA
TCANI?1'AAT
CGCTAAACGC
CGI'ATATCC
AAGAGTTGAA
ITCTGCATGCA
TAGGATATAT
TGTTI'GCAAT
TAAAAACAAA
T77r TGGA'rr
CTAACGACAA
'ITTATAAAGT
AGAAACAAGG
TGAGACAATC
TCTTGAAAGG
CCCACCACCT
TAAAGGGAGT
AAATATCCTA
GATAGGACAA
AGGGGGACTA
CTATTTTIGTA
ATI'AAAACTr
AGAAACAATT
GGTGCTCTrI'
TATTAAAGTT
CGGTGCAGAA
GCAACTCAGA
AGTTTCATGA
AGCAACTCAC
TTAGGGGAAC
ATAGAAATAG
GCCAAACAGA
GAGCATCT
TTTTAAGAA
CAGTATTI
AGATCGATTT
GTTTTGAAAA
ATTGGTATAA
GAGAGAATGG
ACGATACAAC
AGAGCAACGA
AAAGATTTCA
AAAAGCTACC
GAATAATGGA
TAGGATIGTG
CTAGCAAAAA
ACTATGCCTI'
ATGAACTATA
ACATTTGCTT
AAAATTAT
TATAATATCA
AGAGCACCAT
TCTCFI'AAAT
CGAAGCTTTA
GCAAGAAAAA
AGCATACGCT
TATGGGTGG
CACAGAGCTA
TGGTGCGGT
TATCTTAGGA
CATAGGTATG
CAATGGTC'rr 120 180 240 300 360 420 480 540 600 660 720 750 INFORMATION FOR SEQ ID NO:1114: SEQUENCE CHARACTERISTICS: LENGTH: 1146 base pairs TYPE: nucleic acid- STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .1146 (xi) SEQUENCE DESCRIPTION: SEQ ID 14:1114
GGTTACAAAA
GTTTTGTCGQ
GAAGAAGTGG
CATGATI'rCT
AGAGCTAAAG
AAAGAGACAh
GCCTI!AAAAQ
AACCAAGAAA
AAAACGAGCA
CTTCAAATGG
TrATCTTACA
AAAGAATTGG
GCAAAAGATA
TI'TAGCAT'GG
AACTI'GTGA
AATCAAAAAT
AATTGATA
OTAGATAC
TTTAATTTCT
TTTGAA
ACTATAAGAT
CTAATGTGGA
'CCGCAAAAGA
TAGAAGACTr TTCTTT1TAGA
GAGGTAAAAT
ATAACCCTCT
CATTCACGCA
GTAT1TITAA
GTGTGTTTTC
AGCAAGCGAT
ATAATATAGA
TTGCTCAAAA
CGATTIGATAA
AAAATGTCAA
TGAGITTCGC
CCCAATCCAA
ATCCTATGAT
TCAAAACAGT
GCT IOCAAAA
GCAGTI'TGGT
AGACGCTCTT'
GGT1TTTTAGA
TTTAGAAAAC
CCTrACTGCT TrATAAGAAA
AGAAGATAAG
AAAAACTACC
TTI'AGATGAA
TCAAGAATAT
TTATI'ACTTG
AGCCACCAAC
GATCAATGAG
AGATGATGTG
ACAAAAACAA
AAAATCTATA
GAGCOACAAA
GGTTI'CTGCA
ATCG TTTA GCTCATITGGT TCAT1'rrrCA ACGAGATAAA
AAAGCTCGCA
AAACAAAAAA
AAGTACAAAA
AAGTCAAAGG
CTTCTTCCTA
GAGCG?1'TGA.
OCTACCACTA
GAGCAAAACA
TCCAATAACA
CAGCTT1GAAA ACGCTTA?1'D
AAATACTTAA
GAG'I CAATA
AAATTGTGTT
TTAAAAAAGA
ACAACTATGC
TACCGGAACA
AGAAGCTCTT
TCAAAGAGCT
AAGAAAAAGA
CTrATGGTGA ACCC1'rATGC GrATTACTA
AAGATAAGGC
AAAAAGCGAG
TTrCTAATET GAAACAAATr
TTAACTCGGA
GGGGCTATGA
CTTTGACTAA
TGTTGGLrr
CTAATGAATA
AAAAAGAACA
ATIGTTGCCAA
TGCG2TTTGGA
AAAAGAACAA
AAACAATACG
TGTGGATTAC
GGCTCTAGAG
TCTAGAGCAA
TrATGTTA
CCCCCAAGTG
TCAGGCTTTG
CCGATTAGCT
ATTAGCAGA
TGACTCCAAA
ACGCTTGGCG
AGCTTTTCT
AAACTTCACC
AGACAGCTI'C
CAATATCT'C
CTACAAGATA
GAATAACCCC
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1140 1146 INFORMATION FOR SEQ ID NO:111S: Wi SEQUENCE CHARACTERISTICS: POT/US 96/O91aa 1PENUS 16 0E C1996 810 ()LENGTH: 927 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1 927 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:lllS
AATTTAGTG
AAACCAAACG
GTTTCGCATA
AAAGAAGGGT
AAA'FTACTCA
TGCCAAAAAC
TTACAAAAAT
AGTGCGAAAA
CCTAGCGCAT
AAGGAAATCA
GATGTGATGA
ATCGTAGAAA
CGCATCGGGA
AACTTGCAAG
GGCTATATCT
AAGTATATT
CTGGAAAAAG
AGGCTAATGC
ATGAGAGCCA
ACCAGTGCAT
TGGCTICTGT
CCCATATCTT
TACAAGAGTA
AATCTCAAAA
GGCT'rTGA
TTAGGGAGAG
TTGATAAAT'
AAGAAAGCCA
CTAACGCGCG
TGATCGCTCA
ATCAAAGGAA
TATAATGAAA
CACTCTITI'A
GACTAGAAAA
AATCATEIWIT
GCTCTCACAG
GCATGATGAT
GGCTI'IGAGT
TCAAAAATAT
TITTAAACGCG
AAAGGATTTG
'ITTGT 'rGAT
TATAGAAGAA
AAAAAAAATC
ATGAAAATG
AAAATCATGG
TAGGGAT
ACTAAGGCAG
AACACTTTAT
TrGATGAAAT
TTAGACACTC
GCTTAAAAG
TI'GAAAGGGT
AAGATTGACA
TCATCGCAAT
CTTTTAGAAT
ATGAGCGATG
TITTTGAGCG
GAACGCATAG
GTGATAGGTA
CAAGAAGTGG
AGTAAGGAAG
GCITTTGTAGC
TAAACGCTCA
GCATCGTGCC
CAGGGCTCCA
CGATGGGCGA
ATGAAGAGTT
CAGCCACGCA
TITTAGCTCT
GCATCAGTAA
AAAAAATGCG
ATGAAATCCC
ACAAGGTGTA
AAAACGGGGT
GCGAAAAAAA
AAAAAAGCTT
TCTI'ATAGGC
T1'AGCCCTT T1'ITAAAGAC
TCATCAAGAA
TGCTGAATTG
TTTGAGTTTG
TAAGCAGGTIT
AGTGCCTI'IG
GCATTTAAGC,
CGATATI'TAT
TTATGAAAGC
TGCGCGCAT1'
GAATATCAAA
GG77TI-TrA
GCAAAAACTA
120 180 240 300 360 420 480 540 600 660 720 780 840 900 927 INFORMATION FOR SEQ ID NO:1116: Wi SEQUENCE CHARACTERISTICS: LENGTH: 1176 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc..feature LOCATION 1 1176 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1116 TTI'CTGTCTC TAAGTCTCAT AGAAAGGGAC TTGAAAACTA TGGCAAAGAT =\T'AGATA GAGATGAGTT AAACACACTT TATAAGGCAA
ATCTTGCTTA
CCATGAGC ATTATrCAA AVTrAAAAAA GATOTAGACT
ACAAACTCTT
Y7TA TOCATG AGCAATGTI'C TATAAGCTIT GTAGGCGGAC AAGGAGCTAA
ATTAAAACCT
TGCTAAAAAC
TA.ATCCTAGC
AAGATTATTA
POT/US 9 1 PEA/US i 6109121 6 0 E C -196 TACATACTCT ACAAGCTCGC TACGCCAAAA TGTITTTGCA GAACAGCAAG GTITTATI'GA AAAGATI'ACA GAGAATTAGA T*'AAGACAAT TCTTGAT1'A AAAAACCTAG CCTTGCTAA TI'AAAGAGTI' T FIAAAAAC AATAAGTGTA TTCTACTTAT ATAGAATTAA AACACATI'CA GGTAGAAAAG AGAGAAAAC TGGAIAGTG ATGAITACAG AAGCAAAAAT CACAAAATTC GCCCAAATCA AACATTACAA.
GCAACACTCA ?I'TATCAAGA AGCTCCTTAC TCTCTACTAA GCTCTIGTGT TTGATAGT
ATTTAATGCT
AG PTGTAGCA AGTCA LTAAA
ATGCTTAGTG
TGGATAGA
GACCAAAGAA,
ACTCTTAGAC
TG3TAATAC'rr
AGTAGAAGAG
TTATATTAAA
ACTAAAATAT
TTTIAACGCT'r
ACAATATGGC
AACCCAAGAC
GATTTATATT
GATAGAGAAC
AAGTCTAATA
AGAACTCTAA
GGAAAACAA
AAGAGCAAGA
AAAAGGCGTT
AGCTITACCCA
TATAAGCCAG
GCGGGACTTA
CAAAACTACT
AAGAGI'TGT
TTCAATGGAG
TATAATTTA
ACAGGCTTAC
TTAGTTAA
CATACCACAC
AAGAAG
AGATTGCCCT
TAAAGAATGT
GATACTTGTA
TGGCTAAGTA
ATGGCTI1GA
GACATI'TAAA
CTACAAGCT'
GAAAATGCGA
CTA'TITTAAT
TAGAACCAAG
CATATCTCTT
TCCCCTTAAT
ATCTATTTAG
CTI'CAAGGGC
AAGAGCATAA
AGATAGACAT
CAATATATI'A
TGTGTATCT
TIGTGATGTAT
TITTACGCTr
CGATAAAGAC
TGAAAAACGC
AGTGTTAAAC
TCAAGGTAAA
CTTrGAATGCT
TAAAAAGGAT
CTTTAAATTA
GCATAGTTI'I
GTrAGGGCAT
CAAGAAAGTG
300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1140 1176 INFORMATION FOR SEQ ID NO:1117: SEQUENCE CHARACTERISTICS: LENGTH: 510 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .510 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1117
AAAAGAAAGG
GGTITI'CAC
CAGCTCACTA
.TTATATGGA
GAAGTCCCCA
GAAAAATTTC
ATGATACCTT
ITTAGCATAG
ATI!AAAACCA
AACATTGCAT
CTCTI'TATT
GCCCTACGGC
AAAACTTAGA
TO2CAATTAGT
TTTGCTCAA
GGCTAGATAT
CGGAGTTCTT
AAGCTAATTC
GAAAAATI'rA
ACAAGCGGAT
TAAAGGCATIT
TAGATGGAAA
TGCTA'TICA
TGCTAAGAGT
ATTGAACTCT
TGATGAAGAT
ATITTACGCT
AGGCATWA
ATGACTACCT
TTAATGGTTA.
GAAATTITAA
GTTTCTAATC
TITTTTACTCT
~TCTCTTr
ATAAGTGACA
GAAAGCTTAT
TTTTT'AATrC TTI1T AGG
TGACCGTGCT
TCAAAGAAAT
CAGGATGT
ATGTGTGCI'
TITTAATCGC
CGCCTTA
CATTGAACAA
ACTrT2CTATI' TG~CTTrAAAA
CAGCTCCAAA
GCCTTATT
TCTCTTAATT
TCATTCCAAA
INFORMATION FOR SEQ ID N0:1118: SEQUENCE CHARACTERISTICS: LENGTH: 627 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO PCUrTiLi S 9 6 IPENS 18 0'91?2 UCA I (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .627 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:lllS
AAGTCTCGCA
TTTTCAGTAG
AAAAGCAAAG
GGGGTGAT'rA
AACACCCAAG
TCTAATATCC
GTGAATTTIGG
AGCAATGAAA
ATAGAAATTC
CT'TAAAGATG
GTCTITI'CA
ACTI'TAGCTA
GAATAGGCAT
CCC
4
TI'TATT
TCATGCTGCT
AAGTCCAAGC
AGCAATATTT
TCTCTCAAAA
AGCTTI'TGAA
TATCGTCTAA
AAATTAAGAG
CTGATTTCAT
TAATCAAACA
GGCAGAAGAA
TGTCArATT
TATGGGGAAT
TAATCCTATG
GGTGCTTGGG
TGGCAGACGC
TGAAGTCAAG
AAGCGTGGAA
CCATTTGAAT
TATCCAA
GA.AAAAM'rr
CAAGAAAATA
GGAAGCGTGC
AAGGAAGAAT
GCGAACAAGA
CCITTTGTATG
TACCTTAAGG
GTTAAAGACA
GAAGTGGTTA
TCGTTTTGA
GGGAAAACCA
CCGCGCAACA
TAGTGATGCT
CTAAAGAAAA
ATCAAGAAGC
CGATTGATIGC
CTCTAI'TC!
CGGCGATTA
CTAACAAAGG
TTGATGGCTl'
CTI'TAACTTA
ACCCCAAAAA
'TTATTGG TG
CGCTTCTAAA
CAAAGAAGGC
GCCTITrrGCG
GCTAGAATTG
GGACACGATI'
CAAAAACAAG
TATTAAAAAT
INFORMATION FOR SEQ ID NO:l119: Ci) SEQUENCE CHARACTERISTICS: LENGTH: 549 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc...feature LOCATION .549 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1119 GGAAGCAT3A
GAAAAAAAAC
TTCCAAAGAG
ATAGAAATCG
TATAATGGGA
GGTITTTATGA
CATAAGGGGC
TTAGCGCAAG
TrTAATA'rrT
AAGCATITTA
TQACGGAAAT
CAGGCTTGGG
TCAATGCCAT
CGCACAACCT
GGAATCCGGA
ATI'ITACCGC
ATACGGAATT
GGTTGCCTAA
TAGCTTTACC
GGAATAAAG
GGAGAGAATG
GCTCACAAGC
CAT 'LTGCGT
GCGTTI'TTAT
TTATAACACG
AGGCGAGGGT
AGAATGGAG
TTATGAAGTG
CTCATTAAAA
GA?'ATGG
TCGCTCATI'C
AACGATAAGG
CATAAGGCGC
AAGACGCCAG
GAAAGGCTGA
GTITTTCCCTA
TTTG~CAAAAG
TAGACACAAG
GTCGTTGI'A
AAAAGCATTT
TGGAAAACAT
AGTTATIT
GGCATTTGCA
TTAAAACTTT
GCAATGAATG
AGCGCGGGAG
CCAT3?ATTT
TTATAATAAA
GAA.AAGGGAG
CGTGTTTGAT
TCGTG3AGGAA
TTTTATGTG
ATCCATGAAA
GCCTAAGGAA
CTCTr=GCG 120 180 240 300 360 420 480 540 549 INFORMATION FOR SEQ ID NO:1120: Wi SEQUENCE CHARACTERISTICS: 1< LENGTH: 825 base pairs TYPE: nucleic acid z CC) STRANDEDNESS: double TOPOLOGY: circular I PEAAJ S 0 E~ 1996 813 (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) -ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1 .825 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1120 CCAT1TGA
GAAGAGAATA
AT'ZTGGCGG
TrTTACA.AA
GATGAGTT'IG
GTGGATAATA
CAAATGGAGA
GAGCCTATTC
CATAAAAAGC
GCAGCTAAAG
TCTAAAACCA
AACAAAGCCT
ACTAAACGCT
GAAGTCAGCA
AAGGATTI'I
AT'GGGAGTGG
TGCTIT'AAT
CCGATAGTGG
AAAGCTTGAA
TTAAAAAACA
TGAAAACAAC
CCATGAGCAC
CTAAAGTAGC
AGCCAAAAGT
ATCTTACTAA
TITTTACAAGA
ACCTCATAGG
AGAAGATGAC
GATGTCAGAA
TACTAAAAAG
GGTG77"rrGG
CATGCAAAAA
TATGGATTCT
AGAGAGTGAA
AGAAGAAAAA
TCAAAAAGAA
GCCAAAAGAT
CAAAAAAGAA
AGGGCATTAT
GTTTAATCAA
CCCTTATAAG
TAAACCGGTT
AAAGAAAGAC
GTGTTTTITGA
AAAAGCACCA
ATAGGCAACA
CCCAAACAAG
AATTCTATGC
CAAGAATCTC
TCTCAGGCTG
AAAGAAGCGC
GCTCGTAAAG
TTGCAAGTGG
TTCCCCCATA
AGCAAGCAAG
GTCATAGAAG
TGAATGAAGT
TCGTGGCCAT
GAGTCGCTCC
CTAAAGATGA
AAGACAAGT
CCATTICAAAC
AAAAAGAA~
TGGCTAAAAA
ATAAAGATAA
AAGTTITCTAA
GGGI'ITrGC
AAATTGAAGA
AAGCCTTAAT
TGCGG
GATCTTAGAA
AGCCAI!ATC
TAAAGAGACT
GAAAAAAGAC
AGACAAAGTG
CGATCAAGCT
AAAAGCTGI'
AGAAACCCCC
AGCTAAGCAT?
GAAAGCTAAT
GCACACCCCC
TAGGGGGGCT
GCATGCCGAT,
120 180 240 300 360 420 480 540 600 660 720 780.
825 INFORMATION FOR SEQ ID NO:1121: SEQUENCE CHARACTERISTICS: LENGTH: 567 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc.-feature LOCATION 1 .567 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1121
TCAAGGCTTC
GTGTTGTTTG
GTGGTTTTIAG
ATTAGTGAA6A
GTGGATGCTA
GTTTCCCTCT
GAAGACGT1'
CAAGTGGTGA
kATCGCIT
AAAAAGCCAT
CCACTCGTTG
GCTATGTGT
CGGATTTCGT
TGATGGTGCT
GCGAAATCAC
CCATI'GTAGC
TATCCAGTAT
TCCA TTGGT
CGCAGAAAGA
AATTAAAAGA
GTrGCTAGCC
CATGAAAGAG
T'ITATCAGCC
GCTCGCCAGT
TIGGCTAAAA
CATTI!CGGCG
TCCTAAAGAC
G TTGTGTGT
AAGGCAT
G71'GAGATGT CCTTTAT GCA TTGT GGCACA
?I'AGGTTTAG
TATGAAAGCT
CACACAGATT
ATTTTCTI'GC
ACGCCCCTAT
TCAGCGCTGT
TGGAAAAACT
TTGCCATGTC
TGCTCAGCCA
TGGA'ITTGTI'
TTGITI'CTAA
TrAACGCTrT
TCAMCGCTA
CGCATAACCC
TAACCGCTGCT
GATTGAAAGA.
GTrAGTGTTG T1'TAGACACC GTTCAT GGCC
ATI'AGACAAG
AAAATI'AAAG
cATGAG'TrTA
TATTTTGG
TACCAATAAC
120 180 240 300 360 420 480 540 567 P CT/ U t 1PEAtUS %/O91~2 I ~i L~o INFORMATION FOR SEQ ID NO:1122: SEQUENCE CHARACTERISTICS: LENGTH: 711 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .711 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1122
GGTI'TGAACT
TTTI!ATCATG
TTGGCGTCTC
AGAAATGAAA
7T17-17I1,rAG
ATAGACAAGG
ATCCTTTATG
AAGAGCGCTA
GTCAAACATG
AATAAAGGAT
GAAGCTTTAA
AAACCCAACC
ATATrGAT1T
GCTTCGTGAG
GCTATI'CTGT
CCATGACCAA
CTCTTGGAGT
CGI'AGGGT
CGCTCTCTAA
TI'TCCCCAC
TGGAGAAAAA
CTATTGATAA
AAGAAAAGGC
AAACCCCACC
GGCGTTACTT
TGAAATAGCA
GGCTGTTGGG
TCTCA'I'IGGT
GTTGCTAGGC
TATTTTTITCA
AATGGATTTIA
CATGAAAAGC
CCTTAAAGAC
CGCCAAAGAA
TAAGATT'IG
AATCCCAACC
GTGGTAGTGG
GCGACT1'TGG AATrTTr 'TTrACTG
AAGATGT'AG
TTTAAGA
ATGAAAGACG
GTCGCTAGTA
AACCTI'GAAG
TCTZI'AATA
CCTAAAA6ACA
CCATCTAATA
TAGCCTTTGG
GGATTGTGCT
CAGAGCATTT'
TGTI'GGCGTC
TCTTTAGCGG
CTTTTTrAGT
CTAACGCCTA
AGATCATGCG
AAATGAGCGA
AGGCTACGGA
TOCTAGAGCC
AAGAACCCCT
GATI'AGGGGG
TGGCGT1TAT
GTATGATTTA
CATTITGGGTG
TCTAGGCATI'
GCTTrCTTTC TT1ICAAGAA
CCTTGATGGC
TGAAGTTAAA
TAAGGGCGTA
AAAACAdAAT
A
120 180 240' 300 360 420 480 540 600 660 711 INFORMATION FOR SEQ ID NO:1123: SEQUENCE CHARACTERISTICS: LENGTH: 1185 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-.feature LOCATION .1185 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1123 AGCTITATGGG TTIGAAAACCC TATATTACTA TCACACTCAC AAGTCTATAG CCCCCCAAGA TGCTGGGTIT ?TAAAACCCC TAGAAACAGC GCM- rCTT TGGGTFITr CGTGGGGGCG TTATTGTT ACTGGTGCGC TTITAAGGCr1' TCGCATTCGG ATTTCACTTA TTTATTGCCC ~~CS6 /0912.2 S DEC t
ITAATCATTG
GAAAACCCCT
TTGArFOCT
TCTTTAGGGC
AGAATGATAG
GATTTAAAAG
TTTGACTCAA
CAAAGCAAGC
AACTCCCC'T
ACATrTGCGCG
GTTCAAATCG
TTTCTTCAAA
GCTCCCCAI'
GAAGGCACTT
AATAACGCAT
TACGCAAGGC
TTAAGCCCTA
TT'ITAGTAGC
ACTTCAGGCT
TAGTCCCGGA
TTATI TTT
GGG'TITTAI'
AGGTTGGAAA
ATTACCTTAA
AAAAAACCTTr FrAAAACCCA
CTCAAGGCTA
C* <-.!TAAAGT AA..CCCTrGA
TCAGCGATT
CCAAACCCGC
GGTTTAGCCC
GTTAT13ATAA
GCTTATTGGG
GTTAGTTTAT
'rrTGAGTrTT
TAGCTI
AGCTTGCATT
GCTGCTTGGC
TA TMAATTA
TAATATTGAA
GATTGTT TTr
ACTAGAAGAT
TAGCCTTAT
GATCTTAGCC
AAAGCTCrT
TACATTIAGAC
TTATTCAAGC
AAGCATTGAA
AATCATCITG
CGATATTCI'
GGGGTTTAT
TTAGGCTCTA
TCTTATAGCG
'TTI'GAGCG
GCG7IGGAT'
GTCTCTACAA
AACAACATIC
CCAGAGACCG
TTAAGCGCCA
AACAGCTCGT
CCCTTTGGCG
TT TGGCGAGA.
GATTTCACTT
AGCCCTTCAA
CCCACCI'AC
CACAGCGCGA
TTTAGGAAAC
TrATrTGTr
GTITI'ATCCA
TGTITAGGGT
CTCAAAATCT
TTCAT'rTI
GAACGCCCCA
TI'AAAGAAAT
CT1'ACCCTAT
AGATCGCCAT
~IIT TTTC
AGATAATGCC
GCGCTAT
TrCGCCCCTI' AAG'TTrTAT
AAAGAACGCT
ACTTTTCAAC
GATCA
GCTCTATT
CCCTZTTGGA
GGATAAATrA TAAAAAATAc
TAAAATAAGC
AGATTTGAAA
CAAACTCGCT
CGCTTI'AGAA
TI'IAATAGGG
TAAAAAAAGC
TTTACCGGAG
ATACCGCAAC
GATITrGCTAT
CCTAATGAGC
TI'IAAAATAC
TTCTI'ACATT
240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1140 1185 INFORMATION FOR SEQ ID NO:1124: SEQUENCE CHARACTERISTICS: LENGTH: 648 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .648 (xi) SEQUENCE DESCRIPTION: SEQ ID N0:1124 GAAACGATCA TGATTAA.AGC GGCGTGAATI' TGCGCATTAA GGTAAAAGCA CGCTI'I'AAG AGTI GTTAG AACACCAAGA CGCTITA)AkG TCGGCATCGT GAAAACTTGC AAGTCGCTDC CAATTAGGCA TAGCCCACAC CAACGCTI'AA GCATCGCCAG CCCACCGGGA ATI'TAGACAC ATTACAGAAA ACGAAGGGGC TGCTCTCAAG TCTATCGCCT
GATTGATATT
ACCCAAAGAA
CCATI'rGGCC
TATTTATGCC
ITITCAATCG
AATCCTAGCC
CCTAAAACAA
AGTGCTCT
CACTACCT
GTITAGTCTTA
AGAAAAAGAA
TCTCATGCTT
AGCCTIGGCGA
ACCATGCTAA
CTAAATTCCA
AAQCAAGAAA
GGCGTGGGCG
AAAAAACCCC
AATCAAGTCA
GCCACGCATG
TTGAAAAACC
T1TTTAGGCGT
AACCGGATAG
AAAAGCTTTT
TTAAGGG'rI'
TAAATCATI'IC
AATTGAGCGG
AAATCATrAT
TCAGCATGCT
ATGAGCATTT
TCITI!ATAAT
GAGCGGGAGC
CGGAACAGTC
GGAATTGCGG
TAGCGCTTTIA
CCTTTT'AGAA
CGGCCAGCAA
CGCTGATGAA
GCAAAATI!AC
AGCCTTCACT
TCTTTGA'rTA AGGAAAAA INFORMATION FOR SEQ ID NO:1125: SEQUENCE CHARACTERISTICS: LENGTH: 183 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) PCTUS 96/0912.2 IPENJUS 18BDEC 1996 816 (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .183 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1125 TCGCTCGCCC CTAAAI'TAAA AGCGTTIT AAGGTAGCGT TATCCTIGTAA GGCGGTGATA AAAATCACAG GCGTAGAGAT TAAAAAATCG T'I*TATGC GCTI'GAATAA T1'CCAAGCTA TTCA'ITCAG GCACTTGCAC GTCTAAAAGC AAGAGGIAA AGCGCTCAAC AGAGAGCCI'I
TCA
INFORMATION FOR SEQ ID NO:1126: SEQUENCE CHARACTERISTICS: LENGTH: 900 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature.
LOCATION .900 (xi) SEQUENCE DESCRIPTION: SEQ ID NO;1126 TrrGCGTI'GC 'ATAAAAAAGT TCTGTTGGCT TTGTTCGCTA AGGATAAAGA CTACACTTTG~ AGATCTGACT ATTC TGGGCA GGTCAATIG TGGCAAGATG& AAGAAGT1GAA AAAATACACA TITAACTGCCA GCTTGATT G
CTCACCCAAC
ATTAGGAATG
GGGGGTTCAG
GCCCCTI'ACG
ATI'GATGTGA
GTCAATATCA
ACTTATTGGG
CCITCTTCA
GGGATGATCA
TTTAGGGACA
AATGAAACCA
AAGCTAACCA
CCACAGGTGT
GGCATAGCGA
CTCACATGA
TCAAAGGTGG
TCACTAAACC
CTAAGGCTAG
TCAAGTCTT
ATAAGCATGT
ATAGCCCCTC
ATGGGATTAA
AAGCATI'GAA
GGG=GTATG
TOCGACGCTC
GCTAGACATr
AGGCAGCGTG
TATCCCTAAT
AAACGCTGW
AGGCAACAAC
GGGTATCCAA
TAGTATTTCA
AGCCTATI!AC
GGCAPAGGTrT
GTTATAC
GGAAGCCGCA
GAAGCTI'rAC
CCTACTATCC
ATGTTAGTTA
TTCCCTGTTA
CAATATGGGC
CAATGGGAAA
TTTGrCCGCTC
CTCCTCTATA
GCGCAAGCTA
AACTAT1'GGC
CAATACTACG
CTACTGCCGG
GGAT1TACCGC
CGGTGATCTC
AGAATGTCCC
AAATCCGTGG
ATGGTATTCC
CCITTCAAGC
CTAACACTTA
ACCAAGCGGC
CCCCTGATAA
ACACTTATGT
ACTGGGTT'AG
TGGATGGGGT
ATTTTGCTAT
CCAAGAGTCT
TAAAAAGGAT
GCCTAAGAGT
TAACAAAGCG
CGGTCTGCAA
CTI'TGGAGCG
TGTTTATATG
CATTG&TCGC
TGGGGGTATT
TGAAAGGATC
AACCGGCGAT
GAGGACGA
AGGCCAAGGC
CTATGACATC
CGCCCAACCG
120 180 240 300 360 420 480 540 600 660 720 780 840 900 INFORMATION FOR SEQ ID NO:1127: SEQUENCE CHARACTERISTICS: LENGTH: 825 base pairs TYPE: nucleic acid STRANDEDNESS: double I PENUS 1 9i 196 TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc..feature LOCATION .825 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1127
GTGTCAATAC
TGGGGAGCG
GGGGGGI'AA
ACGGATAAAA
GCTGATGGCT
AACGCAAGAG
TTAAACGATG
AAAAATGCT
CTGTCAGCAA
GAATAIA
GATTATT
AAAGCI'GTG
GGTAAAGGCG
CTAGGAI'AA
TAGTTATAAT
TCAAAAAAGC
TGGCAGAGCA
ATCACTAG
GTGCAATCT
AGAGCATTGA
CTGAAAAATG
TAGAATATTA
CTTrTTTATAA
CTAAAGCTI'G
'ITGGTGAAGG
AGTTGAACGA
TGGCAAAGGA
AAGAAGCATG
AGAACCT'AC
GGTITTAGG
AGATCCTAAA
AGCTAAGAAA
AAGAGAGGTI'
AAAAGCTCT
CAAGGAC'ITA
CTCTAAATCT
CGATATGATA
CGAGTTAAAT
CGTAACAAAA
TGCTAAAGGG
TGAAAAGCAA
CGATATTCTC
ACTITTI'ACA
GT=TGTT
GAGCTTATAT
TATTTGAAA
TATCTAGTG
GAACACACCG
GCAGAGIT1T
TGTAAGTTAA
AAGGGTTTGA
AACGGTGGAG
GATTTCAAAA
TGI'ACGCTC
ACGACAGAAA
AAAGAACAAA
AAAGGGAGGA
TGGGGGCGT'
TITCAGGTAT
AAGC'ITGCAA
GTAAAGCCAT
CTACTGCTAA
ATTTTAATGT
ATAATGTI'GA
AAAAAGATAA
GGTG'ITCTAA
AAGdTrI'GA
TAGCAGCGTT
ACCTTAAAA
AACAA
GAGTGTCATG
GTGFI'IATGC
AACTA?1'TAC
ATCAAACGAT
AGCGAGAGAA
AGTIGTAAA
AAACGATCTT
AGGGTGTATG
AAAAGATCTA
ATTAGGAGGG
ATATI'CTGCC
TTATAATGAG.
GAGTTGCAAG
120 180 240 300 360 420 480 540 600 660 720 780 825 INFORMATION FOR SEQ ID NO:112S: SEQUENCE CHARACTERISTICS: LENGTH: 417 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .417 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1128
ACCCGCAAAT
CTCATI'AAAA
AGTATI'AAAT
TTTGGCGGGC
ATCAAACGCT
ATCTTTGAAC
VCCAAAGATC
CATCAGCATC
GI'CAGGCAT
ACTI'GCTAGA
AGAAG TTI'
ACAACCCTAG
TCCAACAAGC
GTAAGCTGGC
CATGTCAGAA
CACGCCAGGC
AAGCGTGGGG
AGATCTAGTG
CTGTCTTrA
GGGCGTGGAT
TATTIGAAGGC
AATGAAAAAC
ATTGTCCTAA
CTAGTGC'Tr
CTAGAAAAGT
GAAGTGGATG
GTGGTGGTI'
TACAGAATG
ACCCCCATAG
ACCCCCACAC
TAATGAGCGT
GCTTGAAAGT
GGGGCGTGAA
CAGGGAGTA
TCAGACAACC
GGTTTCAA
GCATGAAGAA
GAATCCGGGC
TAAAGAACTG
TGATAAAAAT
TATTIGAA
TCTTGCA
IPEA/US
91 01 18 912.
DEC 1996 INFORMATION FOR SEQ ID NO:1129: SEQUENCE CHARACTERISTICS: LENGTH: 945 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .945 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1129 AAACT'rrrAA A'TrGTTI'C
GTGTI'TGTGC
GAATGGGTT
GATGGGGCA.A
GATGGCACGA
GTGAGGA'ITG
TI'ACAAGATC
ATI'GGAAACA
GGGGTTrTAG
GGGCTTATCA
ATTGTGCATG
CAACGCCCI'
CTTGTGGTI'A
CAAAAAAGCC
CTTAAAGAAA
GAGTTTTACA
AAGCTITTAAG
GGCCCACTCA
TA.ACGCTI'T
AAGATGCACA
?I'TTAGGGGC
GGAATTI'AGG
TCAAGCAAAA
CTTCTTTTTA.
ACATCAAAGC
TTGCCACGCC
CTTI'AAGCCA
TAGTG7I'AGG
TTGATGGGCA
CCACGACCAC
AGCTGTTATG
TA.AGATGATI'
CTACAATATA
TCATCAAAAC
AGAAGATGAG
ATTGATAAAA
TTIA.AGAATG
GIIT7 G
CAGGATCAAA
TGCGATCAAT
GTGCGCGGGC
CCTAGGCTCA
AAGCTATATT
GGCGGAATTT
AGCCACCTAC
CAAGCTC~rA
GGGGGAAAGC
AAAAAAGCGG
CGCATGAAAG
GCTCTTI'TA.
GGGTI'rGAAA
AA.&GCTI'ACO
ACGCATGCTC
GCGGTJY3AAT
TTAGAAGAGC
GAAATCGTGA
CATACGCCCT
ACCGCTTATA
TTAACGCCCT
TGCTTGAGTT
GATTTAAAAG
CAAAAAAATT
CCTAACAAAA
CTAAAACCCC
ATITAAACAA
AAGAGCTAGA
GCTI'IATGAT
CGTI'TI'GTG
ACAATAAGCC
TGAACGGG'rr
A'I'I'GGCTTT
TCGCTAAAAA
TI'AACACTI!A
A'ITTGAGCGC
TGTGCGAmT
TTTGCGCTCA
CCAACCAACC
CAAGGGATTA.
AAAGA
GACTATCGGC
GCAGGCTAAA
TGATAGCCTI'
T1'TAGGAGGC
ATGCTTTGGG
GAAAGATI TC
GGAGGGCCGT
AAAAGCTI'TA
TAAAGGCGAT
TCATGGGCCC
TTCI'TAACG
TGAAGACGCT
CCTATACAT'
TrTTTAAAGTG INFORMATION FOR SEQ ID NO:1130: Wi SEQUENCE CHARACTERISTICS: LENGTH: 654 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .654 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1130 CCCCCATGCA AAAAAAGATT TTTTTACTAG AAGACGATTA CCTTTI'AAGC 1PEAAJS Q/ UjI-7 ~DEO'IZ356
GAGAGTATCA
AAAGAGGCTC
GTGCCTGAAA
ACGCCTGTGA
TI'AGGCGCGA
AAAAGGI I
GCTTI'GAACG
TATTTTTTAG
GAGCAAGCGA
GGTAAAAAT
AGGAGTI'CT
ATGAAAGGCT
TGAATAGCTT
ITTrATCAC GCGAT ATTTF
TCAATIGATGA
TTAkA.GGGAA
AGCATAAAGG
TI'GATGATI'C
GCATAGAAAC
GGAGCATITA
CTcTGTTGAG
GGAA'ITATTC
CGCCTTACAG
GAAAAAGCCT
TCCGATAGAA
AAAGGAAATC
GCAAATCATC
CACCTTACGC
GCATAAGGGG
CGCTATGAAG
CGCTTTAACC
AAGCGCATCA
GATAACGCTA
TT GATITTG
ATCATGCCTA
TIACCGCCCCA
AGCTCTCAAG
ACTI'ACA ITA
GTGGGCTATC
TGTTI'CGC
TCTTGCTIT
AAAACGATTT
CCTTAAAAAA
ACGAATI'GGA
ACA~rFI=A
AAACCGCCCA
CG~TTAGAAAA
AAGTGTCG
GCTTTAACCC
T='rAACGGG
AGACGTGCAA
'ITTA.ATCTCT
CGCTTTTAAT
AGCGCGCAT'r
CCACCAACAC
ACTI 'rAGAA
CAACTTATGG
CAAGCTTTG
ACTA
120 180 240 300 360 420 480 540 600 654 INFORMATION FOR SEQ ID NO:1131: SEQUENCE CHARACTERISTICS: LENGTH: 1074 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1 1074 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1131
TGTGGCGCTA
AGCGGI'ATA
GCGTGGGGGC
CTCAAAGAAA
GAAATGTA
AACGACTACC
GTCCAGCATT
CTAGGGGG?1'
GGCATOGAGA
GACTACGCTA
GTGAATCAAQ
CTGGTTACAG
ACACAAGGGG
CAAGCAAGCC
AACATI3CCAG TATr-rGTTGT
GTGGCGAACA
GCTAAAGCGT
ATCGCTCAAA
GTAACGAAGC
AGG3AT?'GGT
AAGCGACTCT
TIAATAAAAA
CTATIT1'AGC
ATI'TACTIGGC
TGTCGGGTGC
GCGCGA.AAGT
AATTACAAAA
CCAATATCAT
CGAGCCAAAC
TAGTCA'I GA
ATTCTAACCC
GGATTGTCGC
ATTATI'rAGA
CGCTITGGAGG
TCAATCTGGC
AGGGCGTGGA
GTATGAAAGC
GGTCAAATGC
GTTI'AGTTAT
AATCACTrCT
GCCTATGAGC
TrAGAGCAT
GCAAAGGGCT
CTTA.AGCCA6A
CCACCCTTAT
TCAAGCCTI'A
CCCTAA.AGTG
TGTGGCTTGC
GGTGTATGTG
TAAAACGAGC
GCATGGCTTG
CTI'GAGCGCT
GTI'CAAATCG
GGTTrAGTI'
GTGGGGGCTA
AAAGAGCCTT
TI'GGATTTAG
AI'TGCACTG
GTGGTGGCTG
GTI'AAAGGGT
AAAATCGTCG
ATOGGOCTA
TATCATI'rGT
AACGGGGCGG
ATCTTAAGAA
AGTITrAGGGG
GAAGAAAGT
TCTACGGCTI'I
AAGGGTTT
TATAACGGCT
CCTI'TAGAAA
CAAAATGCGC
AAATCGTGGA
TAGAGCATGA
CGTATCAAAA
AAACCATTGC
GGAGGTIGC
TITATGGGTAA
TAATTGGAGG
AAGTAACGAT
ATGATTTAGA
TGGGCTAGT
GGCATrTAAA
GGTGCA.TA.AG
TGTTGCATTA
ATAGCCATOGC
TAACAGCCAA
ATATCACCCA
GGGCGCGAAT
TTCTAAAACG
ATACCCTIG
AAGCTTGTGT
CGGGCCTAAA
TGCGCATTTA
GGGGGTCATG
CGGTGTG?~
TI'rAGAATTIA
AGTCTTA.AGC
GGGAGCGGTG
ATACATGCAG
AGCCATACGC
T=GGTGCCG
GAGTtGTOCCG
CACTAAAATC
AGAAGGCATC
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1074 TITTAAAGGA GCTT INFORMATION FOR SEQ ID NO:1132: SEQUENCE CHARACTERISTICS: LENGTH: 489 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) PO/W 9 IPENUS .L /O I BDEC;i IW6 (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc..feature LOCATION .489 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1132
AAGGGTAAAA
GTGCGTCAAA
ATI'AGTGGGG
GGGCTTAAAG
ACGGAAGAAT
AAAAAAGAAA
GCGT1'ATTAA
AACGATAT
GGGTAAAAAA
ATGCCGTTTI'
CTAGTGGGGT
AGAGCAACC
ACGGCATIVFI
AAACACOCTA
AGGGGCT'1AT
TAATGCTCTC
CATCGCAGAT
TGAAA.AACTG
GGGGAAAAGC
TI'CAAACA?1'
TAGAGAAGAT
7ITTTTAAAC
TWACGCTI'A
CI'ATTAGAT
TTCAATAACA
GATCTGGAGT
GTCCTrAI'G
GAAGTGGAAT
GAGCATGAAC
CAAACAAGCC
TCTAACGACA
GGCTATATCC
TI'CAAATCAC
TI'AAAGATGQ
CGAGCCT1T
TGATCGCGCC
CCTTAGTTAT
TATCTAAAAA
GA7I'CAGCCA
AAAATAAAAA
ACGCTTAAAA
CTTGAGCGCG
AGGGGCGTI'I
T17TITTAGAC
TAGCGTGATT
CACGCTCAAA
GAATGAACTC
TAGGCGTTI!A
120 180 240 300 360 420 480 489
GCCCCCTIT
INFORMATION FOR SEQ ID NO:1133: SEQUENCE CHARACTERISTICS: LENGTH: 891 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc..featuro LOCATION 891 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1133 TCAAATCATA AAAGGGTTTTI' GTTATAGAAA TCATCAGTCT
AAGCCGGACG
GCGGATTTAG
AGCGTT1A
GCTTATGACC
ATAGGGGTIT
TTTGGGCATA
CAAAACAAGT
AGCGGAGGCA
GCAGAAAAT'
GITAAAAACG
'TTCCTTI'AG
GTTAAAAAGC
TTAGCCAGCC
CTGGOAGTTA
CCCTAGATAA
GCGAAGA.AAA
CCCTAGATGG
ATGAAAAQGA
AAATAGAATI!
TTCATTTTAT
ATCAAAAGGA
ACCGCTTGCG
GCGGAATGTI'
CCI'GATGGT
GTTTIGCTAGA
CGCATGAAGC
TATOGGATTAC
TTTAGAAAAA
CACTCAGTTA
GTTTrAGAG
AGAAACGCCT
GAGTTCAGTG
TTATAAGGCG
GGTGGTGGCT
AGAAACCATC
ATACTCAGGA
TTCCTACCCG
TGAAAAAGCT
TCAAAGCGTA
TCAGATTTA
AAACGT'ITrA
GGGGTTAAAA
GAAAACAGCA
GAAACT1TT G1'rACTAAAG
ATGGAGGCGA
CAAAALTTT AG
TTAGAAGAAG
GTflTTAGAAA
GGCTTAAAMA
TCTATGGTGG
CAAAAGAAAT
AAAGGGGAAG
GAAAGCTACC
GAAAAACATT
AAGGCAAGCA TGCGAACATC AAGCCCAAGA GATTAGAA GCGGOATAC GCCTATTAAA TGAGITTAGA GAATGTGAAA AAAACGGCTC TTATL'TGATC ATTTCTTAGT AGGCACGATT TIGCAAGCCT TrATGTGGTT Tr1TATCGITA CGCTI'ITrAT ATAAGGGTAA AATCATCGCT AGGCTTTAGA AGGGTTTT CTGAT GTCCA TCATGTGTG TGCGAAAGCT TTTrGAAGTC CGTrTATTI' TGATAAGGGG ATGAAAAAAG CGAATGCTAT TAAAGGGAGA A 120 180 240 300 360 420 480 540 600 660 720 780 840 891 INFORMATION FOR SEQ ID NO:1134: IPEANS 18 DEC 1996 821 SEQUENCE CHARACTERISTICS: LENGTH: 789 base pairs TYPE: nucleic acid STRANDEDNESS: double (0C) TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc..feature LOCATION .789 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1134 ACrFFITI'AA
TCCATGAAAA
TCTGGCATGG
ATGCATGCGG
GCGCTCTI'GG
TTTGACTACG
GCGCAAGTGO
GATCCCAGAA
AATGTCATCA
AATTCATGGC
AGCAAGAAAG
AAACATTCTA
ACTGCAAAAA
TTCACTTTC
TTATTr'ITrG
AATTTTTTTC
ATGGTAATGG
ATATTAATTC
GGTATCAATI'
CTCATGCCAA
CTAGTCAAAT
CTITTTGAGCC
ATAACGGCAT
?1'ATGGCGAC
CCACTC'T
GCATTGAAGC
ATTI'GGATAT
GGTATCTT
TCAATCTTTG
CGTTITA
TCAAAAACAA
TTTC ETTGAA
TTCTATTAAG
TCTTGGGAAA
GAACATGCTC
CATGAGTI'TG
ACCGAGCTTT
CCAATTITTTA
GGGCGTGAAA
kGGGTTTAGG
TTAAGAATI'A
TTAGCTCTITA
GGGGCGGGTT
GCCACCAACG
AAACACTTTG
CTI'AAAAACC
CAAGAAATCA
ACTTATGGGG
GGGGCTTTTG
GAGGGCATIT
TI'CAATGTGG
TTCCCCATGC
CGCGTGTATT
AGCATrATGT
'ITATCTCTAT
ATTGCAAGG
CTACGATCAA
GCITACGCCT
CTAAcTATAA
ATCGTTTAAC
GGGCTATGGA
GCGGGATACA
TAGTGGAACA
GGGCTCGCI'
TAAAGAAAAA
CGTGGTATGT
TAAGGAATTA
GAATG3CGGTA
ACAGGCGCAA
AGGCTTIGAC
TTATGGGTT
TAGCGAkGCG
AAACATTGCC
CGTGATGGT'
ATTGGCCGGC
AGCCCTTGTG
AAGGATCTITA
CCCCTACATC
GAATTACGTG
120 180 240 300 360 42 0, 480 540 600 660 720 780 789 INFORMATION FOR SEQ ID NO:1135: Wi SEQUENCE CHARACTERISTICS: LENGTH: 702 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .702 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1135 TGCAT GACG CTAAAAATAL AGAAGAAGCC ATCATTCAAG GCTACACTAT AGCACCGTTA TIGCGACGCA CACCAGCGAA TTAGTGAAAA A.ATACGCTGA SACCAAAGATG AAGTGAAATC CCrI71AGAG CGCTTGGCTA AAGACTATCC GAAGAGAGTA AAAAAATCCC CACCGGTGCG ATCCGCTCAG TCTTGCAAGC CAT1'GATCCA
AGATATC
TACGA LTGTA
CTI'GTTGCAT
~/O9122 IPEAiUS '~UECi9%
GAAAAAATCC
T GGTTCAAA
ATCACCAACG
AGCGAACAAT
A.ATGTGGGCG
CAA.AAAGGGA
AATCAAATGG
AACTCTAA'
CCATI'AAGGA
ACGATGTGAA
CTITI'AAATC
TIITGCTCA.A
AATTIGCAAAA
TCGCTCCGGT
AGCAGGCTAG
TI'GAAGCCTT
CATGCTCACT
TATCTTAACC
TGAAGACCGG
TAAAIGCGA
ACTCATTGAA
GATTTTGATI'
GATI'GATGTG
AGGCACGATC
ATITTTGGAAA
GAACAAGTGA
CGT'rIGAAAT
GAAAATGGCA
GGGGTTTCTG
GTAGAGCCTA
GTCGTGCTAA
CACATI'AACT
CGATTACTGA
GGGCGAGGCT
TTTrAACCTr
CCTCTAAGAG
AAGAGGCTAT
ATTAAGAAA
GCCATGCGGA
Tr
TATTGCTCCA
TI'CTAGGGTG
TCTACCGAT
CI'ATTACTC
GAAAGTCI'O
AGCCCTCT
ATTAGATCCT
INFORMATION FOR SEQ ID NO:1136: SEQUENCE CHARACTERISTICS: LENGTH: 885 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-.feature LOCATION .885 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1l36
AAAAAAAAGA
GCTI'TAGGGG
CAGTCCC?1'A
GAAAAACATT
AAACAAGGCG
CATCAAATCA
TTTGTTTCCA.
TTGTITTTCTC
AACCCCAAAA
GAGCATITAA
GAAGAACGAT
GAAGAAGTTA
ATCCAT1'TGG
GATITCATGC
ATAGAACAGG
CCCTAAACAT
ATAACCTCAT
AAATCCTAGG
'rrGAAATCAT T. .LTL J.Gi
AACGI'TGAT
TAACCACTCC
AAArI'rATGG
AGATTTTGAT
'AATCGTlwTT
ACGCTI'ITTT
AAAACCTGAT
CTTACTATTT
CGCCTAATAG
AlTTAGCCAA
TTCACAATTA
CACGCTTAGC
CACTCATTTG
TCCTGITTI
GATGAAGGAT
TTTAGAAAAA
AAATAAAGAA
GCATGTTITTT
CAACCCTI'TC
AAAACTCTTA
AAAAGACAGA
TTAGAAAGC
AAAGAAAAAT
TGGGAATGAG
AAAATTCCGC
GGAAAAACCA
CTI"1'IAAAAG
ACTTTAAAAA
GAAAATATCC
LTrrATGGT CAAGAT1'NTA
ATIAAAAACG
GATAACCCTC
ACAAGAGAAA.
AAACCCTTTDr
GTCGCTCATT
GATTTGTATA
TAT 'ITATCT
AATTTCCTAA
CATIGGGGC
TGCATGTTGC
AAATCGCTTC
TCGCCAAGCT
CTGCTITTTTA
TATI'AAAAGC
GAAG?1'TICT 'TrTATCAAAA
CATATCCCAT
ATGATAGGAA
GTGTTACGCT
ATCGCGCTAA
TACGGOGGA.
TITTATAG;
AAGCCCATAA
TATTA
TrIGTCTITTrG
CAAACAGCAA
TTTAGAATGC
TGACCTI'AAA
AATTAAAAAA
TIrATCCCAA
CCGCCAGGAG
GAGTI'TAAAA
TATTTCTTTA
TITAGATITl'
AACCAGTI'TA
TTCGTI'ITG
GGATAATG3AC
AAGCCATI'TC
120 180 240 300 360 420 480 540 600 660 720 780 840 885 INFORMATION FOR SEQ ID NO:1137: SEQUENCE CHARACTERISTICS: LENGTH: 204 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: No (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE:
.F.
POT/iub S/o9I2 I PEA1U S I bD EU .0 j 0 ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .204 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1137 AACACACAGC GCCAAACACT CCCCCTAGTC AAGTCCCGCC CACACCCCCT AGTCAAAATIT TACCTAAAAC AAATGTGTGG AATGGGGTTI' ArI'GGCTTCA AAACAAAACT TAPTCAAACA AAGGCATTTA TTATATI'GAT CCCAATCmT CAGGACAGAG CGGTCAAAGC GGCAACACGC TCAGCACCTA TACAGCTAAT TTGT INFORMATION FOR SEQ ID NO:1138: SEQUENCE CHARACTERISTICS: LENGTH: 4239 base pairs ,Z3) TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1 .4239 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1138
ACGCTAATAT
ACAGCAAGCT
GGGGCGTTAA
GGGCAGTITG
AACATCACAA
AGTGGGGCTA'
TATAGCGATA
ATCATTCAAG
TCGGCTTCCA
CAAAATCCTA
ACAAGCAACA
ACTTATAGCC
AGCGAGAATT
ATGATI'GAAT
GATAAGATI'A
ACTGACAACA
AATG~rACAA
GCGCTAGATA
TCAACTTCCC
ACCGGGACAA
CAAAGCGCTA
ATCTTTAATC
AATG LTCTTA
ATAGAAAACG
TTAGGCCAAC
AATGAAATCC
TCCATCATAG
CTTTGAA'T
CAAT1'1'ICAG
TTAATI'TTGA
ATTTAATGG
TITTAGGGAA
AATCTGTAAC
ATGGCTATGA
ATAACAACAT
AGAGCAITAA
ACACTATTTT
CCGGCTATAQ
TTAAAGGTCT
CATTTAACCA
TAAAAACGCT
CCAACCAACT
AAATCACCCA
TCAATCAAAC
ACTCTACTAG
GCGCCACTG
CI'ATI'IAGG
TTGGAAGTAG
ATAACI'AGT
TTTGGGTCA
GTCAAATGGC
CTCTAAGCCC
TTATAGGTCA
AAAACATTAT
AAAACTACCT
?I'ATCGGTGG
CGCAAGCCAG
CAGCGCAAGT
TTATGCGCCC
TAATGGGGAT
TTACAACATC
AAAAATCCI'r
CCAAACTTGG
AAATCGGGGAT
TAATATCGCT
CTAT13AT1TAT
TTTICACCCCT
GCCTTTIGAAT
TTTrAGGGATC
AGACAATATC
AGCGCAAAAG
CTTTAATAAC
CTCTATATGG
TTCTTC ITr
CTACATTAAC
TAACGCrrT
GTTGAATAAA
AGAAGGGAT'
TATGGAAAAA
T'TTGAGTAAG
AAATAACI'A
CAGTCAAAAA
TGCTAAGCAG
GTATATAGAC
GCTGATTI'I'
TCATTGAATI'
TCITrAACTA
ATTAATTTAT
TTAAACGCTrC
TTATGGCA
TCGTTTATAA
CTAACCATAG
CCTGAGCTTT
AGCGACAATC
AAAGGCTCTC
AGTTTGAATA
CITTCTCAAA.
ACTAACATTA
CAAGCGCTCC
GGGAATCTCG
TTTGGGGGCA
AGAAACACTT
GCTGAITTA
GAAAGCGGAG
GCTAACATAG
GATAAAATCT
ATCAAGCAAG
GAAI'ACCCG
GATGATTAT
CTAAGCATTT
TCTT1'AAAAA
GCTTCTGAAT
GAGGCAACAC
TTAATAACCT
AGGCTI'TAAT
CTGACATCAA
AAAAAGGGAT
TGAAAAITCCA
ACCCTCTCAA
AAGTTAA6A
ATAATTACCA
AAGCAGGCAC
AAACGCCTCA
TCTACAATAA
AI'CCGCCAC
GACTAT GAT
TACGGCTAAT
GAATGTCAGC
TATCTI'TGAC
TACTGGCATI'
AAACGCTACC
TTCTTCTAA
TAACCCTAAC
AGATTCTAAG
TrATDACTI'G
AACCCCAGGC
GGG.TrrrCT
CTTAAAAGAA
ATGAAGTGTr GCAACTCTrP 120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1140 1200 1260 1320 1380 1440 1500 1560 1620 1680
TAGAAACGAT
TTATAGGCGC
ATGGCTATAG
ACTTC.GGGCA
AAGCTAAAAG
GGAGCGCGGA
AAGCTCAAGC
T'TAATCAGGG
CCGGCGGTIT
CTAGCTTGCA
TGAATAATAG
TTGGCAA=I.
GCATGCTAGA
TAAGCTCTAT
CAACCATTG
TACCCAAGAT
CAGCCCTTGC
ATrATTAGGC
CATATATT
TGTAACCI'1'
CACAGACAAT
GAATflTAGCG
AGGGAACTT
AGATGAAACC
TGGAGTCATG
TGTI'ACCCCA
CGATAAAGGG
TI'TAGGCGTO
PTUS 9 6/i2 I PENUS nbL 3rS
ATITTTAAAGG
AACGACTTGT
TIGGTGAGTA
cAAGG=rAG
GGCACTCTII'
TrAAGCAATG
AAGTATCAAG
cTAAACGCCA
GGAGAAATTT
TCTAGCGTAA
GGCACAATCA
GGCACGCTCA
Gc LTTTAACA cAAGCCACT
GGCGATTIGG
ACAGCGACGA
GTGGGTACT
ATCACAGGAG
GGCAACCACA
AAAGATGGCG
ATI'CTTTATA
CCCACT1'TAA
CAAGCTGGGG
hTATTACTAA TGAACGAGrI'
ATATCATCAA
GGAGCGTG_3r
TATCGCCTAG
GCTATGTr
TCGCCAACAA
GCGCATTGAT
CTAATGGCT'
GTATCAATTTI
CCCCCACTAA
TCTCTAATGG
ATCTCAAT13A
ACGCCTCTAA
TAAGCACTAA
TG'rTTAACCT
TCATGGCCAA
ACACGCTGAT
GCAGTAGCCT
TGGTGATGAC
GTTIrAGTI'GT
ATAAAGTGAA
AACAATATAT
GAAATCAAGC
cCCCCTACA
TI'TAGGACAA
TAATGTrATT GCCGCccTCT
AGGCTTGCAT
TGTCAATAAC
GTCTATTATC
TTTTGCTrCT
AAGCCTTAAT
AGCCAATTGC
TGAGTCTTTA
GGCTATTIGAT
AAATGCGACC
CTCTACGGCT
CGCTAGTGGT
CAGTCATTCA
TAATAACCCT
TGATAGCGCT
GGATAATTAC
TGACAACGGC
AGGCT1rAAG
AATCGCTGT'
CGCTCAAATT
GATTAATI'GG
TCTAGAGAGC
AGAAGTCATC
CTACACGCAG
CGCTATGGAT
GACAGGAGT
TOTAGGGTAT
TAGCGGGI!C
TAGCCGAGCG
CAATAAAACT
ATACGACACT
TAAAAGCGI!
TTrAAGGGGC
TAAAA.AATCC
CTCTTATTAT
TAAAATGGTG
CACTITTTOCT
TGCGGGCATA
TGGTATGCGC
AGCCTGCAAA.
GATG;TIGTCA
TCTCAAGGCG
'ITAcAAAACG GATTI' GGC
AGCTCTTTTA
TrrAATIGGCG
AATGGTGTT
GCGGG TrGA
CCTACAACCA
AGCGTCCACG
TI'GTCTCAAG
TITGCAAGCTA
AATATTGATG
TTGAATGTCA
GTTAGTCATG
TrGATCCAAT AAAGCCA'TT1
CTTAAGCTTTI
TI'AACCTATA
GACTCTCAAA
TCTAATGATC
CAGGGCGI'C
CTCAATAAAA
CACTCCACAA
GCTAACCCTA
CAAATGAGTC
GAACGCTI'AG
GTGATTTTAA
GGAGGGGCTA
GATAGGI'TA
CATGCAAACA
TTTATCAAAA
TTCATCAACT
TGGACGACTG
ATI'TIAAAC
ATTATGGATG
GTTICTAACGA
TTuTGTATTG
CGTTTCATCG
AGCATTATCA
GQGGCTAGGT
TATGCTT
AAGACAT'GG
AAAAGCTAGA
GGT IGAGCGG
CGCTCAAAGA
AAAAAGGGTA
GTAACGCTAC
ATAATACGAT
CTAATATCAA
ATAATGTGAG
AAAACAGCTC
CTAATAA2TT!
TAACAAATAA
ATAATTTAAC
GTAATTTCAC
TGGGGAATTr CTArrATCAA
TCAACGCT'C
ATTACGGGTA
ATGCGCTCAT
ACGGGCAAGC
ATCAATACAT
CTATCAATAA
AAAGCGTGGA
TCTTTGAAAC
AAGATTTAAC
ATTTTAAAAA
GTTTAGCCAA
AAGCCCTTAA
AATACTCTCA
GTTTCATTAG
2-rAAGGGCGT
TCACTCAATC
GAAGCGAGCT
CCTATGACCC
ACGCTAAAAT
CCCAAGTAGG
ATCCTAT'rA TCAATT1GC
CGGATGTGG
GTAATAACAC
CAGGCGGGGA
TTGGGCTTGA
TGTGGTAGCG
AAGTCAAGGC
CGTEI'ATAAT
AAACGATITA
TrrTrAACT'rr
TGGCGGGTAGT
TIGACTrTAGC
TATCACCACC
CGTrCAAAAA
TCCTGCAAAC
CACITI'CTTA
TAGCGTrATA
GATCACCAAC
CTTAAACCAA
TAATAGCTAT
TACTCAAGGC
TI'CACCAGAA
TAACAACCAA
TGATATTAAT
CGTGAGCGTT
TACACTTCC
CCCACA.AGCC
TAGCATCGAT
TAAAGGAAGC
CACGATCGCT
TGACGCCACT
GCTCTCTGAC
AAACAAGdGA
AAGGAATAGA
TGGAGGTACT
GATT'1GTGGGA
AGGCTCTAGC
AACCATGAGC
CCTACTCTCA
CAAI'ATGGC
CTTAAGCTAT
CAACCAAfrrC ccTAGAAAGT
CAGAGACT!A,
CCTAAGCTAT
GATAAGATTG
'rTATAAAGAT 1740 1800 1860 1920 1980 2040 2100 2160 2220 2280 2340 2400 2460 2520 2580 2640 2700 2760 2820 2880 2940 3000 3060 3120 3180 3240 3300 3360 3420 3480 3540 3600 3660 3720 3780 3840 3900 3960 4020 4080 4140 4200 4239 CCT TATTCG CTCCCTATTA GGAGATAT1G CTAACACTT AATATI7TLAC AGATCAACAC ACT1'CAACTI TCGCCCGTI'C ?I'COCTGAT'G CGATCCCTAA GTIAAAAATA ATOTOTGOC GGAACTTTAT ATGGTATCAA GGTI'ATGCCG CTATGGGTA AATGTCAATG TGGGCGTI'TA TTGAATGAGA CTTGGGGATA ATCATCAATC AGTCTTACAG TATGATTTCA TGTrTAAAGA TATTACATTIG GTTTGTCTGG AOAGCCAATG CTGACCCTA CGGCATTATT TCAATAAAAA TTCATrAATT CTATGGGGGA AGAGATOGG GCAGATACAA TrCAAAACCT TI'TAT GTGAA ATTAATATrA cCGGAAATAT INFORMATION FOR SEQ ID NO:1139: SEQUENCE CHARACTERISTICS: 'LENGTH: 579 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: 7 NAME/KEY: miscjfeature 0 LOCATION .579 PCT/IS 9 0/ ui RPEAMS 18 DEC 1996 825 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1139
AGGGATAACA
GAGCATGGGA
ACAGACCCTA
TrACITGCGA
ATGCAACGAA
AATGAAATAG
CTATCGGT
GAGAGCGGTT
TATATTAAAA
TTAGGGGCAC
.rG-GAGCTTAT
TTAAGTI'TGA
GGGAGTTIGT
ATAATI'GCGC
AAGCTAAAAA
AGG TTTAAC
TTAGAGCGCG
TATGGCAAGG
GCTCAAGCAA
TAAAATTAGG
TTTAGGCTCT
ACAAAAAGCG
CTATTTGGCG
TATCGTGGTG
CAAGCGAGAA
TTGCTCTGCA
TTTAAAGGCG
AAGTGCGGGC
GAATTTAAGC
GGTTAAAC?'r
CAATCCAGCG
CTCTATTTTG
TGCAAGGGGA
GCTGATAGCG
GCCCTAAT
TTGA'TrCTC
TITTGATTGCA
TGTGTGCGTT
CTAGGGCGAA
ATGAAGAAAG
AATTAGAAAA
TGGTGAGCGT
'TTrAAAACG
CTGTGTI'GGA
GCGAAATAGA
TAGAGGACTT
TCITIAAAA
CCTAAAAACC
AGCTAAAGAG
GGGTAATCGC
CCAAAATGGC
ATGGCTGGAT
AAAATATrA
TCATAAGCCT
GGAAGGCTTG GTGGGGTI'GG GGCTGAATGT
TCAT'A?'A
INFORM4ATION FOR SEQ ID NO:1140: SEQUENCE CHARACTERISTICS: LENGTH: 504 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .504 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1140
AGAATGGCTC
GCTGI TI'A
AAAGAACTT
CTI'GTGGGCT
TTGAGCGAAA
GTATTCAATT
GATAACAAAC
TACATCACGC
AGTTTTAAAA
?IrTGGTTC AA.AGAGTAAG TCTCTGATGC GCATTFITG TAAGCGCCAA ACCCCCOCAA ATTTACCCCT AGATAAACAG TTTCACAAGT C'TTTACTTT CCAAAGTAAT GGTrTTGAG GCI'TTTGCT AGCCCATGGG AGCTCACI'C CACTT GGG CT CCTTATACCC TI'I'
ATGTTAGAAA
CCCAAAAGCC
CAGCAAAAAA
GAAGGCAACC
CGCCAAAACC
GATI'TATrCA
AGATTT
CTrATGCACT
CTCATTITAAT
TGGGCGATAT
TCATrrGA?1'r ATGATI"ITrC
AACCCGCAT!
TCACTAAAGC
TAAC~rri-I'
TAAAAGTGG
CCATACGCIT
1?I'CCATGTT
AATCCA.TGCG
CATGCGTTr ATrCCAGTAT
GTATGAATT
AAATTTATTA
120 180 240 300 360 420 480 504 INFOP14ATION FOR SEQ ID NO:1141: SEQUENCE CHARACTERISTICS: LENGTH: 960 base pairs TYPE: nucleic acid STRANDEDNESS: doubl* TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori r'LIIU 31
IPENUS
9/O09i D DECQ 1996 (ix) FEATURE: NAME/KEY: misc..feature LOCATION .960 (x ii SEQUENCE DESCRIPTION: SEQ ID NO:1141
AATGATGATG
ATGGGAACOC
AAGATAGAAG
'r GAAAGCCC
CAGCCGCAAA
ATCGTGGTGG
ATTAATTTGC
ATACTCAATG
ACGGOATA
TTAAGTTTAA
CATTICCATCA
AAGGCCGATG
TTTIAAATCTT
GTGGAGAATG
CTTGTAGGTT
CCTTTG3AAAG
AGAATAA.AGT
CTAGTT ITGC
TGGTGGGGCT
CAGAGACTAA.
GTTTGAAAGA
TGGCTTATGG
ATGCGTCGT'
ACGATAGGAT
vrMrAGAAAG
AATTAGCGCG
CAAGAAAGCC
GGTTAGTGGG
GGCCAGAAAT
AAAAGAGCCA
GTTI'AAAGG
CGAAGGATTA
AATTGAATTA
TGAAGT13ATC
ATTCACTCAA
AACATACATI'
GCCTGAAG7I'
TAAGATTI'G
ATTGCCCAAA
TI!ATGGCATA
CGCTI'CTI'
CATGGGGGCG
TCAAGATCAC
'TTTrAAAGAC
CTITTTTAGAA
CAAGGAAGGC
CAGCGTGCGT
TTTGAATGGC
AAAACAAGGA
TTAAGGGCGT
AGGGACAAAC
TTAGAAAATC
CAAATCTrAA.
CCTAAAGAGG
TACAGGGGGG
ACCACCATGC
TI!AAGAGAAG
ACTCTGCTI'C
ATGCAGGCTA
GCTAAAAACT
AATAGCCTTA
GAGATTAG
ATAGCAAGGT
AGGCGTGA
ATAACATGCG
T GG ETGAAAA CT7TGGGCG
ATTTAAATAT
AAGGTTTGAA
rTTrAACCAT
CTTCGCCCAT
TTATGGATrI'
ATTAITTGGA
1"TC7AGCT
GTTITTGTAA.
TGTTTwTA AACTrTAGA
CAATTGATGA
TGCAAGCGGT
AAGTGGGCGG
CATCGTATTT
TGAAGATAAA
CAAAAAAGAA
TCCCATTIC
GCCTGAITIWII
CGCTCCTr'GC
TCATGAGATG
GGAATTGGAT
TTTAGACGCT
CAAAAATI'1D
AAAAATCGCC
ATCGCTI'GCG
AGTGGAGTTA
AAGAGGCGTT
GGGTAAAAAG
TATTCTAACA
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 INFORMATION FOR SEQ ID, NO:1142: SEQUENCE CHARACTERISTICS: LENGTH: 513 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc...featur* LOCATION .513 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1142 AAAAGCAcAA GGAAAACAAT AATGGAAGCG, GGCGTGTI T
ACTAAGACTT
TTAGATAAAG
TCAGTCGCTC
GTCATTGATC
AAAATCCCTA
GTGvGCGTTAG
ACCATGCTTA
TACGGAGA
CCACCTACAC
ATGAAATI'AT
AAATCAGCTA
CCAATCTAGT
TCAT'rAGTAT
CCATTACCGT
AAAAAGI'CC
GATI'ITAGCT
TTCGCAAGTG
VTTCCCTTAT
CAACCAGTIT
AACCCCCACT
CGCTAAAGAT
GGAGCTGACT
CTGCAAAAGT
CAATTACQAT
GAGGCTAAGA
CGTGGAGGTC
GCTAAAGAGG
AAAAGCGACA
AAAGAAGATG
GAAGTGGGTA
AAATGCGTG
CGC
TTACGGGTGT
TCGTGAGCGG
CCACTAA.AGT
GCGAGAI'GA
TTAAAAAAGG
AGGAAA.AATA
ACATTATCAC
TGGAGGGCAA
GGGCTATGGC
GGATATT1TG TTITCATGCITr CGGTATCGTr
CCAGCTTAT
GCAATCTGTG
120 180 240 300 360 420 480 513 AAGAAAATAT CGTrCTAGAT INFORMATION FOR SEQ ID NO:1143:- SEQUENCE CHARACTERISTICS: LENGTH: 1284 base pairs TYPE: nucleic acid STRANDEDNESS: double POV!K 9/0 9 12a2.
IPEANS l8DEC1196 827 TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-.feature LOCATION .1284 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1l43
GCATGTTTAA
TGCAGATG
?I'GAAACAAT
CAAAGTTTTA
AAXITI'GAT
TGCCAGTITA
CGAGATGGTT
ACTTATIGTCT
GAGAG'I'TGG
ACCACCAACC
GCGTTAAAAT
ATCGCTATI'G
TTAAATAAAG
GTGAGTTI'CT
GAGTTTGC
TATCAAAAAG
GAAGGGGCTG
GATGTGATAG
TCAGACAAA
AACGATGT
AGOAGTCI'A
ATCTATGGGA
AACAPLGAAAA
ACGCTATGCC
TAGAAGAAGT
SIIIIAGGATC
ATTGGTTTCT
TCTATAAGGA
ATTTIATI'CCA
ATGCTCCCAG
AAATITTTGCG
AACAGGCGTA
GTTTAGATAA
TAGATACCAT
AAGTFI TGG
TACCTTI'C
TA.ACAAGCCC
ACGTTTCATC
7IGGATATGC
AATGGGTGAA
'TTATI'TTCT
CTTTGI'GTC
GGACAAACAA
AGTI'AAAAAA
TA'rrACTAAT
TAAAAGTTA
?TTTCCTAA.A
TTTATGCG'T
TTI'AGGAGCG
GATTCACAAA
AAAATT
ATTTAAAA
TAT1TTTAGAA
TIGTATATCTC
T'rACAGAAAA
TACTTTAGGC
GTGCTATGTG
ACACCCTAAA
TGAATACCCT
'ITGTGAAKAA
TTCATATrr
TTTCTI'CAT
TCCAGACGCG
TTGTATTA
GCAAGAGAGG
GAAA
ACGCAGATAT
GGCATAGCAA
TACAAAACAT
TT'ITATAAAA
ATGCAGGCAG
AGAAATATTG
AATATTTAT
AAAGCGGTAT
GGCGAAGAAG
TATAGCAAT'
TACIGTI 'r
TATI'CTTCGC
GATCTCCTAA
CCCGTIVIAT1I
ATI'TTAAATG,
CACCGCTCTA
AAAGAAAGTC
GACAATCCTA
ACGCATAAAA
AAGCCTTCAC
TTGT1TTAAAA
TGCATATCGG
CGCTATrAG
TTAATCCAAC
ATTATAI'CA
GAATTGCAGC
ATACTTTAGT
ATCCAAATC
'TTTAGAAGT
AAGTTAAAA
TTGAACATTG
CATCAAATTTr AAGGG2TAAT
GAATITTTAAA
TTCATAATTG
TAGAAAATGG
AAGCTTATIGA
AAATTTCTTT
GTATTCAAGA
ACGCTCTGCC
AAAGTrATAG
TATTGTCTCT
TGATAATTCT
AAAAAGCGTG
CAGTGTI'GCG
AAAACATIGAA
CGTTGC'ITAT
GTTI'GTGCG
ATATAAAACT
CGTAGAGGGC
GAAGCAAATC
CCGCCATTTA
AGAAGGAAAT
CCAAAAAOCT
TTATGATTGC
GGATITrATG
CGTTCCAATC
AAAA-ATAGTA
AGACATTCAT
TCAAGAGCAA
CTTGT17TGC
CGTATTAAAA
AATTAAAAAA
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1140 1200 1260 1284 INFORMATION FOR SEQ ID NO:1144: SEQUENCE CHARACTERISTICS: LENGTH: 1125 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .1125 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1144 GGGTTA?1'AG CI'GTrIGCT GGTCTI'ACTC AATCTAAAGA TrACGCCGAA TTTGATGTGG F2 LNZ &ET PcTus 9 6/609122 1PEhW~US cuu.u 828 CCTrAGATA ATGAGCG?1'A
GTOGGTATAG
GATATGGGGA
CAATGGTGGT
AT'PATTAT
ErrTr~Tr
TCCACCGTGC
CCTTCGTGGG
AAAGAAAGCC
CTAGAAGGCT
A'1'IATAGGGC
ATGTATCACA
?I'CCAA 1711r
GGGATCACGC
TTCATTGACA
ATGTATIA
AAAAAATTAG
!TTATTGrTGGT
GAAGAGAGAA
CGGTGATGTA
GCG~rG3GCA
GGGGGCATAA
TCTTGCCTAA
CGAGTTTGAT
CTGATTGGGT
GGACAGCGAT
CTTTGATCAA
CCATTCAAGC
ATGTGCATGAX
TGACCCCTAG
GGATCATGAC
AAGGGATGAT
CGGTTAAGGC
'rrGGATTrAT
AGCGTGAGCC
TGTGGCATGG
TAcTATTTAT
TATCTI'CAAT
TTCTATTTCT
TGCGGTCGCT
AGAGAGCGGC
GTTTGTAT
ACAAACCCT
TAACATGCTI'
GTITAGT'r
CATTAAAAGC
CGGCGTGCCI
GC1~T1CAAA ?1'TAGGGATT
GTGGAGGGAT
GCTAATCCCT
TATI'TI'GCT
CAATrIACGCC
GTGI'AT=G
GTGTCTTTGT
AACC'ZTTCTA
ATGTATTCAG
TTTGTCTTTA
CAGCCTATCT
ATr'GGGCGG
TCTAGCGTGT
TTAACGATGA
T1'AGCCTCAA
GTGAACGCCT
GGGTGGGTAG
AGAGAGATCT
GTGCTTrACT
GTGGATCAAT
TATTACAATA
TACAATATCT
ACGCCTATG
GGGTI'AATAT
GGTA'ITACAT
TCCCCACCTA
GCAGTAATGA
CCAGTGGGGT
TrTCTTACAA
GCGGGCACCA
TTTCAGTGGT
GAGGCCAATG
CTTI'CTACAT
TAGCCCACTT
GCTCACTTT
ATTCAGGAAG
'TTTCGTCCAT
ACGGGAATCT
TTAGAGGCGT
?I'ATGACAAT
CCAGA
GTIGGGAGC
CGCTACTTAT
T'TI'GTCGCT
TGCGCTCATT
rGATTGGCACG
ACTCAC'TTG
TTI'GATCTAT
GTI'GATCTTG
GCACCAGCTC
GCTTrCCACG
CACCGMTTGG
GATTGCGAGC
ACT1'GTGGAT
GTGGATI'GCA
CACTrACCAA TGGGGGTCTr
CACGGCAGGC
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1125 INFORMATION FOR SEQ ID NO:1145: SEQUENCE CHARACTERISTICS: LENGTH: 903 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .903 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1145
GGTTTGATG
CTCCAAAAAG
CTCGCTCTCA
ATTGGGGGGT
TCCGTAGGCT
ATGCTAGGAG
TCGCCTGAAT
AGTGGGGCGT
TCCGTAGTG
TG~CAT1TITT
ATAGCCATGT
AGCGCGGCI'
TATTTGATCG
TGCGG'1GTG 'lCCGCAAT
ACGATATGGA
ACACT1'TAAA
TITTTOGGCA
PTATGGCGAT
CTAAAGCCAT
CGATCATTGC
TrATrAACGA TATGGI'rGCA
GAGGGATITAT
TATCCGGCAT
TTTTAAT
TAAAGGTCGT
TGAAGGTT
TCCI'GCGCT
TAGAAAATAG
AATTAGAAAC
GATCGCTCTC
GGCTAATTCT
GAATATTGGC
TAGCATGGGT
TGGGGGGAA
TGCGCATGTT
TGTAGCCACT
GGGGGCTGGA
TGTGGCTAGT
GCTCAI'AAA
GCCTITATTTG
AAAACGCCTC
TTTGA'rl-I r
CCACGAAAGC
ATCAAAGAGT
GCTCTwlTTGT
AAGGGATTGT
GCGAACGATG
GGGGCGATI'1 GTGTTrCTA
TTCATTAATO
TAATAGGCG
ATGGCAGCAG
TOGGTAATCT
AAGACTATCG
GTGGCGI'GA
TATGCGGTGG
ATCCTTTTrA
GTCAATGAGC
TTGAAAAAGC
TCCTCATTGG
TCTATCTr
TGTCTAATAA
TGATCGCTGC
CGATrAAGGG
TCATGTTGGC
CTCCCGTI'rC
CTGGAATGTC
CGCCTTAT
C1'rATAAAGA
TCGAGCTTAGC
GTI'ITGAAAT
AAAGATTTGT
T1TTTAATGT
TTCCAAAAAA
CGCCGCTTTG
TG3CGGCCGTG
TGTCGGCCCG
GGTITTaTOAA
CCGTATCGTT
TAGCCTTTTG
CACTI'CGCAC
TGCTATCAAT
GGGGGCrII
AGATAAAAAG
CTTTAGCTGG
CCAGCTCGCT
GrN.AAAAAAA
CCCTTTGAT
120 180 240 300 360 420 480 540 600 660 720 780 840 900 903 INFORMATION FOR SEQ ID NO:1146: SEQUENCE CHARACTERISTICS: LENGTH: 1296 base pairs 1PEAIUS I1s Z; 829 TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .1296 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1146
AGAATGAAGC
AACACGAATG
GAAAAATACG
AAAAACTACT
ACCACAGCGA
GGCACAAGAG
ACTCTITI'AG
ATTATGGAGG
CTTAAAATI'C
TACAGGGACG
GAAACAAACG
CAITTGAATG
CACGATTTAA
CGTTACAACC
CCTTAGAAA
ATTGTACAT
CAAGTTTTG
AGGGATAAAA
ATCTTAACT1'
AAAGGCATCA
AACGCTTTAG
AACATTCAAA
TTAAAAAAAC
AAGTTIAGA
CCCCTI'TAAT
TTGATTTI'AA
GCTTGATGTA
GGTTIwrAT
AGCTITATAG
TGAGCTCCCA
TCACCAATAT
CTAAAAACAG
CCCTTTAA
?I'CAAGCCT'
GAGATCCCAA
TTI'ATAATAT
CGATCGCACC
CTAAACCI'T
AAAGCTTTAA
CCAAGCGCCC
CAGACAATCC
ATAATTCTrC
AAAATTTAAA
TCTI'TAAAGA
CCTGACTI'AT
AAACCCTAAA
CGCAGAAAAA
GATTAAGAT
TTCCTTIGCTC
CGACGACAAA
CGATIGGAA
TGCGATGTC
CACAAGCGAT
CTTI TAAA
CCCCATTAAC
TI'COCTCAAC
TCTI'AAAGAA
TTAGCGGGC
G?1'ATI'GGAA
AGTGGTCGTG
AAATCAAAAG
TAAAATGGGA
TAGAAGCGAA
CAACACCACG
GAAATCC'TT
AACCTGGCTA
GTAGGGATTA
TTAGATTTGA
CACATCAAAG
GAAGCGATI!C
CAAAAACGCA
CATTTAGATT
GATGAGGGCT
GCGCGCACTr
CCTTCCATTA
ACCGCCCTGA
GTTTTAGGGG
AACTTTTATG
GATTGCCC
ATCACCGCTC
GCGATAGCGA
AACGAAGAAG
CCTATTCI'T
I GTCAAAAC TTTGGATTr
CAGGCACTAA
ATAAAAAGAC
AAAAGGGCTT
GTTTAAAATG
TCGCTGGGCT
TCCATCAAAA
TAAAAGTCAT
ACGCACTOGA
GCGCGTCTT
TCCATTCCCC
?I'AAATTGCT
GGGTTAAGGG
ACACAACAGA
Tr'ITTGGGGC
GTTGTTACGC
ACATCATTAA
ACCGAAAAAA
TTTTAGGCAh
TTTAAGCGAT
GCCTTTAAAC
TAACGAGCTI'
TGGTAAAACG
CGCTCTTTA
GACCACGCCC
CGAATACTTC
TGATrI'CGCT
TATAGAA.AAT
CAACAGAGAT
TAAAAAAGCG
ATGCTACCAA
CCl-ITrAGGG
CACTCAATTG
GCGTTTGGAA
CGGCATGCAA
AGGGGGCGAT
GCATCAAATC
GGATAT1W1TA
GGCCATTTA
GGGCGATGAA
120 180 240 300 360 420 480 540 600, 660 720 780 840 900 960 1020 1080 1140 1200 1260 1296 TAAAGTCATI' GTAGAAAAAG AGACGATGAG GTGTTGTTGA.
CAAAACGATIT Trrivr INFORMATION FOR SEQ ID NO:1147: Wi SEQUENCE CHARACTERISTICS: LENGTH: 981 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .981 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1147 PCT/US 96/0912.2 1 PENA1JUS 1 0- D AGATrrATrAT
TTATAGAAA
TGCGGGGCGA
CAAGATGAAA
CTAAAGGATA
AACGGCTACA
GATGAAGCCA
GCGAGTGAAA
GTAACTITAG
GCACGAAAAA
cTAGTGCCAC cAAATCAACC
TCTAATIC
ACAGCCCCCC
CCTTTAAAAA
TI!AGAAAACA
GAAAAGCTTI'
CTCAATrTAA GGGAITFF1
CGAGTAACCC
TCGCTAAACT
TTrI'ACAAC
TCAGCCTAGA
AGCGGTTIATT
GCGCTTTTGA
TC7TI'CGCC
GAGCGGTCAT
A.AAATITTGCA
AGCATGCTAA
TAGCTAAAGA
TAGACGCCCT
TCACAGAAAT
CCGCCCAAAA
TAAGCAGTTI
AACAAGGATA
AGAAAACGAT
TAG'ITTGTT
CAAAGGCAAA
CTCTAGCGCG
AATTG3ACCCC
CAAAACATI'A
AGTCATTAGC
TAAAATTGCC
TAGCGTGTV1
AGCTCAAAGT
TAAGCTAATA
TTACTACATT
AAACGCTTAT
TGAAGCGTTC
ACTCCTTAAA
AACATGCAAG
TI' AAAGC
TGCGAAGCGA
AAAGCTAAAG
TrAATGCCI-r
TIT=AGAAG
AACCGCCCCA
GCTCTGGCTC
GGTGAAATCG
GTCTCACGAT
GGGATCATCA
AGCACCCTrT
AAAGCGCTGT
TTGCTTGACC
AAAAAAGAAT
GAAGGCIT3A
AAITCAGTT
TCATCAATAA
TCACAAAAAG
AAATTTATGA
TGTATGAAAA
ACGATGCGAT
ATGTGATGAT
AAGCCTCTAT
CTCAAATCTT
TTACAAAGA
ACGCTACCGA
'I GCATCCAC
GIT=~AAAAA
CAAACACCGA
TAAAAACGCA
TAGCGT1'CAA
GTGGTGCGAT
GGGGGCTATT
CGCGTTAT
AACTCTGOCA
AGACCCTAAC
TAAAAGCATT
TAAAGTCCCG
CCCCA'I'IAAT
AGCCAAAGAA
AATAGACCCA
GT13TTATT'AT CGGCGI'rAAA
CTCTATCAAC
GTGTCAAACC
CAATATITGAT
ACAATCCTTT
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 981 INFORMATION FOR SEQ ID NO:1148: SEQUENCE CHARACTERISTICS: LENGTH: 1074 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc.fieature LOCATION .1074 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1148 GGGTrTAAAG
GTGCTITAG
ATGCCT%2ATT
AATTACACCT
AAATCCAACC
CCTATTr 'rrTGTGTATA TCAGAGCATr
TTATTGCAAA.
TATGCTGAAG
ATCTATG3AGA
GAAACCITTA
AAGCCTGCGG
GCGGACACGA
CCGTITITTAA
GCTCTTTTAG
TI'AGGGAAGT
TTCGTAI'TC
TGCGTTTG'r CT1TTGGAATr CTG3CCAACAT TGCCCAT1'TC
AATACACCGC
TGATTAGCCT
T GGAAGAAAA
TGTTAGTGAA
AAGCCCAAAA
CTAAAGAAGC
TGCCCTTGAG
AAACGCTCAA
TTCTATCAC
AAAAAGTGCG
GCGTTTITAAT
GGCTAAAGTT
TCAGCATTTC
TAGCTCTCAG
TAGATTTGTG
GTTTITGTA
GATCATTrA
CTTGCTI'TTA
CCTOCTCTCT
GTI'ITrCACG
AACGCAAAAT
ATACAACGAT
TATCAAGGTD
TTTTTT'GAA
TTGAACTG
AAATTTCCGC
AGACGCTCT"
CTCGTT
CGCTA
T
1T TATCAT1'ATC
AGGGATACTC
TC'TTTGGTAT
GGGTGGTATT
GGCATTCACA
TTICACCT
GCGATG3GTT ATTGGATTr
GCTGTTTATG
TTAATI'TATA
GATI'ACGTGT
TI'TCGCCTAA
GACAAATATT
GGCGCGAACG
CCTAAAGTTI'
TTATCCTflGC
TATGTGTTG
TCGCCCAGTC
ACGCTCGT'G
ATI'CCTGAAA
TTTAAAAAAC
ATI'TCAAATA
GCCTGAAATA
ATGATAT1T
TATI'TTATAT
CCAAATGCCA
TGGGGTTGAA,
AAGACAATTC
ATI'I GATAA
AAGATAAAAC
GGAT1ACA
CTI'TAAACAC
TAGACACCAT
ATGCTTTAGT
CGATTGCC
TCGCCCGCTA
TTTIGGGGGCT
TAGGCGTCT
TTAATAAGAG
CTTI'AATC
CGCCGATAAA
ATTCGCTCTC
CACCTTCATT
GAT1VITAAGC
CGCGACTCCT
T1'TGAGCGTT
GATTAATCCC
711'AGA.ATCT
TGACACTACT
CACGCATI'rA ?I'ATCAAiAAC
GCGCCAAAAC
CTI '1TI'GTG
TGAAAACCTG
ATI'CTI'GCT
ATCGCCC TTT
ATTG
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1074 INFORMATION FOR SEQ ID NO:1149: PCTUS 96/09122 IPENIJS 1 Uuv 831.
SEQU.ENCE
CHARACTERISTICS:
LENGTH: 1377 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION I. .1377 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1149 AAGAGAAGAG TGGTGAAAT
CTATACTIAT
ATCGCTCAAA GCCACCATGG GGTGGATACG AAAACGCTCA CTrCTI'cTGG
GCTTI'ATGAA.
AAAAAAGCCC CCCTCATTCC AGAGAGTIG GTCATGCAGC TTTCAAGCAC
CGTAGAAGAA
CAGCGCAACT ATACrITI C AAAAAATAAG GATACGCCTI' TAGAGGCTAA
TAAGCAAGAC
AACCATAAAA AAGAAAGAGA
AAAAAGAGAA
AATGCGCAAC TAAGTAAAAT
CAGAGACAGC
GAGAAAAACC CTAATTCTGT
CAATATCCCT
AAACAAAGCG GCATGAAATC
CAGTCATTA
ATGCC'TI'AC GCATGCGGGA
AAATTCCGTA
CGTAAAATAA TCCTGTGTCG
CCCTGAAGAT
CTTGTAGGGC CAACAGGCGT
GGGGAAAACG
TCTAGAATGC TGGCTAAAAA
ATACAAGGTG
GGGGCTTTGG AGCAATI'GAG
TTGGTATGCT
ATrGACGCTA AGGATTTTGC
TAAAGAAATT
GTGGATACGA CAGGGCATTC GCAATACGAT ATAGATGGOG GTI'ATAATAT
TGATGTATCC
GACATGAAAG ATATTTATGA TTCTrGGG AAATTAGATG AGAGTAGGGG GTTAGGGAAT CCTATCAGI'1 ATCI'TCTGT
CGGCCAAGAA
GAGTATrAG TGGA TG CAT GCTAGATGGC
PAGTGGGGAA.A
CTGGTGT'TA
ATCGTTGTGG
TATGATGAAG
ATGCGCAAAC
ACTCTTAG
GCCTTGTI'GC
GTCAAACAAG
TTAAAACTCA
cAAGAAT1 G
GATGAAATCA
ACGATCAAGC
TTGAATTrGA
ACGAC'TTTGG
GGCATTATCA
AATAAAATGA
GAAGCTGG
AAGGAAAAAA
TTAGTGCTTT
GTGTTAGGGA.
TTGTTTTCTT
GTGCCTATGG
TTTAGTAACC
:GGCCGCTGA
kIAACCCAAGA
-GGTTGAAGA
%ATTGAATGA
rcGccGGGGT kAAAAGACGC
AAGCC'TTA&A
A~AGAAGAA.AT
T~cAAAACAT CCGAAATTrA
TGCAATTAAG
GCTATTI'AG
GGCAAAAACG
CTAAATTAGC
cTTTAGACAA
AAATGAGTAT
AATACTGCGA
TTGCCGGT'lT1
CGGTTACCAC
TTGACACTTT
TAGTGCATGA
ATTTGAAAGT
cTAATAAGGA kGCTTAMG kATCCGTAAA
%GAAGAAAAC
kGAAGACGTG 1'TCATCTAAC TCCA'rIAGAG
PGATGAAG.CC
TAA.AGATATT
GTTTTGGGAT
cAAACTAGCC ccTGGAATTG AGAAGTGI G CATITTTAATr-
CGCACGCTAT
TTATCGCATT
AGAAGCGGTG,
TTTTATTlTA GAAAGAGW1T
TAAGTATGAA
AATCTI'TACG
AAGCCAAAAG
GGCTACTAAT
ACAAGCA
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1140 1200 1260 1320 1377 INFORMATION FOR SEQ ID NO:1150: SEQUENCE CHARACTERISTICS: LENGTH: 106S base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL SOURCE: ORGANISM- Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-.featur@ i" .qZE
IPENS
091kA a aU LOCATION I1.. .1065 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1150
ATCATGGCTG
AATGTGGATA
TATGATTI'CA
CATGATAAAA
GAAATCCAGC
AGCCCTACGA
ATTAATCCTA
TATGATCAAA
CAGGTGATGC
GACGCTAAAG
ATGGTGG 1TIT
GTGATTTCCA
ACGAACTCCA
GATATGATGG
GTGGGGGATA
AAGAAAAAGC
AAAGAAGTGG
CAGCGCAGAG
ATATTTTAAG
'rrCAAAATGT
AGCGCCCTAA
TGGCTAGGAA
TTCATAGCGT
G?1'TTAATGT
GCATCGCTTI'
ACAGGGAGT1'
AAATTTTA)-A
AATCCAGCGC
TAGAGAI'AT
TrGAGAGCAT
AAAAGAGCCG
TGTTTGGG
CTATCCGGT'
GTIATTTAGC
?TTTATAGCGA
GCAAAGTGGG
CCAAGAAGAA
CCAAAAAAAA
TCGTGTGAGT
TCTTCCAGT
GGATCAAATG
CT TICCATG
CCCTATGATI'
TAGCGATATIT
AGAAGTr.TrG
GAATGTGGTC
cATTCGGCAT TC TTTCTAAA
TAATAAGGAL
CGCGGTGGAA
GAATAAAGTC
GAGCGTGGGG
AAAAGAACGC
CGATAT'rATIG
ATTGATGCGC
GATAI'ATCC
AAGGAGCAAT
CAAGTCTCI'
ACI'ATGGCG
AAGCCTATGG
GACAGACTAT
GAATTGAAT
TCGCCTGTGG
CAAATCGTCG
AGCCGTGGGA
ATC4GGAGTA
TT-GCAAGCAC
TGAGTTTGA
GCTAACGATG
TITCAAGGGT
ACTAAAGAAA
AAGATAGAAG
I'I TAGAAGT
CCCAACGCAG
TGCGCTCTTT
CTATCATGCG
AATTTTTGAT
GGGGAACGGG
TAGGGGGTAA
TATI'GGATAC
TGGAGATGTA
CTCAAAATGA
TGATG3AATAT
GGGA'TTCAT
TATTGAGCGG
AAGAAATGI
AAGTGAGCGT
ATAGGAAAAC
T'TTrAGAAAT
AAGAG
CGTTGATGAG
CGTAACCCTC
TAGGAGCATC
?I'CTATTGTA
GAGTTrGCCT
GGTTTTAGAG
GGGGAGCGCG
GATTTTACGC
TCCTACCATI'
AATTTCTATC
TTGTTACCCG
GCTTTCAGAA
GGTGAGCGTG
GGATTTAGAT
GTATGTACAT
CATTCAAA'rr
GCTAGAAGAA
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1065 INFORMATION FOR SEQ ID NO:1151: SEQUENCE CHARACTERISTICS: LENGTH: 891 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic), (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicebacter pylori (ix) FEATURE: NAME/KEY: misc..feature LOCATION .891 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:11Sl
GGAACAAGCA
AAAAGTTI'1
GGCGTGGGA
AAGGTAGGGG
AAAACCCATA
TGCGAGATTG
TACATCAGCG
TTAGATI!ATA
AATGCGAGCG
TATGCATGCA
GTAGCCCAAC
AATATCGCTT
CGCTATGTGA
TCCATI'GACC
CCAAAGAAG
TGAGTAATCA
TTGATAATAA
AATCCAACAT
TATTTGATGC
AAAATATCTI'
AACCCGGGCT
GCGCGGAAGC
TTGTGATTGA
A'I GCGTGGT
TTAAAATCAA
CTAAAGAAGG
CATTAGAATT
GGGAGCGAAA
AGATACAG
G??I'AAAAAG
AGCGAGCCAT
GGGGAATACC
TAGCGCTAAT
GGATATTG3GT
GCATGCCTTA
TTCTTAATC
T1'TGGATCGA
TACGGGTGCT
GATT'GIACC
CTCCAAGAAT
CAGGOCGACT
GCACTATI'A
GATTTTGAGG
CCTTTTAGTT
CTTrTTI'AAA
TTGGATAATT
AAATTCATCG
TTAGCTTACT
TTAGCGAATT
AAAGGCGAAG
ccTGGGGATA
TTCGTAGATG
GGGATTGGG
ACACCCGATC
AAAGATGAAT
TATGAAAGGC
GGGGCGATG
AAAATAGCCC
TCTAAACTAG
AGGCTTIGA
TTATGAACGC
CTATCACAAG
CVI'TATACAA
TAGATGTCAT
CCA;AA GCA
GCGGCGAAGA
AAGAGGGGGT
CCACTACGCA
CTrCAGCGAT
TGTTCCTTAT
TATTCAAGGT
AAAACAGCTC
CTAACGA?1'T
AAACCGGCAC
AGTATTTGGG
TAAAAATCCC
CGGTAAGGGG
OAAAGGTTAT
vrrrgGGGTG
AGAAATCATT
AATTrAA6AA TTrAAGCTCT
AGCGTT'I'T
TACCGATGCG
CGCTAACATG
GGCTAAAAAC
CTTATrGAAA
GTITTTCGCAA
TTrAGAAATA
G
120 180 240 300 360 420 480 540 600 660 720 780 840 891 INFORMATION FOR SEQ ID NO:1152: AlE.""Clo SHEE-11'
IPEAIUS
SEQUENCE CHARACTERISTICS: LENGTH: 1593 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc..feature LOCATION 1593 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1152
ATTTCGGAGT
AAAAAAGCTT
AACAATAAAC
TTGTTATTAG
AAAGACATTA
CAAGAGTAT1'
GTAGAGTCTA
CCCTITTATA
TTACCTGGTT
CAGTTTAAAC
GACGCCGATC
GGCGCGCAGA
TGCGAACGCT
GGCACAGAGC
TACGCCAGGG
TATGTCGCAT
AGCAAAAAAG
GAGGGAGAAA
ATCAAGCCCC
TATGAAAAGA
GAATACCAAT
TATGGTTI'1
GATGCAGGGA
TT'ICCAAGGGG
GTITTTAGA~r
TACGCTGAGT
GCTCATAAAA
TTAACCACCG
ATCAAAATTC
ATGTITACAGA
AACA.AATCT'
CCAT1T GTG
TGAGCGCAAT
AAATCATTAA
AACACAGTGT
TTAACCCTAA
TTTATGAAGA
GATIT TAGA
TCATGACCAT
TGGGCAATCC
'rrGCGCGCCT
CTITAGACAA
TCACTAGGGC
AAAGCAAAAA
TCGCGCCGGT
ATGCCTATG
ATAACGACCA
ACGCTTACAA
ATOGTTGA
TACAAGCCCT
T'rGTGTCTAG
ATAAAAGCTC
TTTlQCGAAC
GACTGCTTGA
CAGTGCGCCT
ACCCACCGCT
GGGCTATGTT
ACAAGAAGCT
CGCCACCAAT
TCGCCCAAGC
GAACGCTTTA
TrTAAAACTC
AAAAGAGAGC
GCCTGCGCAA
AAAATTIAGAG
TCATAAATCT
TAATTCAAGC
TTATTACAGA
AGAAGAAGCG
TGAGTTAGGG
CAAAAA.AATG
TAT1'TCTCCT
CGAGCAAGTC
GGAAGCGATC
CATTCCTAAA
TTACCAAGCG
TI'TTAAAAAT
GATTGATGTT
TCAAAATTAC
TCAAGCCCCC
AAATrATG
TTAATCATTA
TACT 'GGAGC
AAAGTCTCTT
CAAAACCTT'
AAGGACGC'rr
ACGGAATCTA
GAATACGCTI'
GCTGGATACT
GTGGCAAGCT
AGCTGTTTGG
GCTAAAGAGA
AAAGGCATGC
CATGCCAATC
ATGAAAAATC
GCTAAAGATC
CTGATTGTCG
CACGAACAAT
CAAAAAGAGC
CAAGAAATAG
AATr1'rGGTA
CAAAGCGTTT~
T'rAGAAGAAA
CATGCCTTAA
TTATTGTGGG
CAGCAAAGCC
CATTI'rAAAA GTr
ATTATGTGAA
AAAAATACCC
TAGTGGCTGA
TAGAACATCG
TAGAAATCAA
GCGCGAAATT
TAGCGGAAGA
TGCATGATGA
TTGTGTGGAA
AATI'AGCGGT
TCGCT1'CTT
AATTCCCTTA
TACCATT1
TA.AAACTI'CC
TGAAAAAGAA
TATTGATCCT
AAATTA'I'IIG
GTCTCAATTG
ACCTI'ACAAG
TGTGATCGCT
AATTATGGAG
TGGGTGCGAA
CAATCCAAAA
TGTGATTGTG
AACTCCTTGA AGAATATGAC GTGAGGTGGT GGATAAAGAT 120 180 240 300 360 420, 480 540 600 660 720 780 840 900 960 1020 1080 1140 1200 1260 1320 1380 1440 1500 1560 1593
ACGAAGAAAT
TGGCCAAAGA
TGGAACTCGC
CTI'TAATGAC
AAGAAGAGTC
TCGCCTrGCA
TAGAATATT
GTTTAGAGCT
AGGGTGAAGC
ATAGAGGGCA
ATAAAGCGCA
TACAAGCGGG
TAATGTGTAT
CAAGAAAGAA
ACCI 'TAGAA AAGCGTrrGTC
AGATAGCGAT
TAAGGGATTG
AAACTACCAC
1rr "TG.AAAC AAATT GTAT
AGTGTCTCAT
CATTATI'TAC
INFORMATION FOR SEQ ID NO:1153: SEQUENCE CHARACTERISTICS: LENGTH: 759 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO POUS 96/09122.
1PENUS U~6 834 (vi) ORIGINAL SOURCE: ORGANISM: IHelicobacter pylori (ix) FEATURE: NAME/KEY: misc..feature LOCATION .759 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:l153
TTATCAACCG
GAGCGATCAC
ATCACCAGTT
AGAA.ATGGGG
CTCAATTCTI'
GCCGCTI'ACC
CAAGGGGGCT
TACATCGGO
GAGTITrGGCT
GGGGTGTTAA
?I'TAAAACCC
AAAGAT1'ATG
TTACAGATIG
CTTATCAGGC
CATCTTCACC
CTTTCACCCT
TTATCTTTAG
GGAACGGGTT
ACCATTTGCA
ATATCTTTAG
GCGTAACCAC
TGTGGCTTGG
AAGCGGCTAA
CAACTAGGGG
GCGTI'GTAGG
AATGGATTTC
GGTAGAACTC
AGAAATAAAA
TGATGTGAGC
TrCCTATGCG
AGGCGGGAAT
AAAATATTTA
GTATAACACC
GGTGAGAGGC
AGGCGATGGG
AATGCGTTTA
GAGTTI'rCTTC GGCTGGGTTr
GCCCATGGGG
CATTGGTTCC
GGTATTTGG
TATGACAACA
ACAATGTCTG
GTCCGTAACA
TrGATAGAT'
GATGATTACT
T1'TAGGAACG ATTT TACCG GCGTIGGTT17T
TATAACGCTC
GAAAGGGCGA
CCTTGGTGT
TGAAAGCTGT
ATAGGGAT'A
CCGATGAITA
GTTI'GCCAAG
CCAAAGTTTA
TGATCGCTCG
TGCCCTrAAA
GCTCAATCAC
CTTCTACTGA
TTGACTTTGG
CCACCACGAC
CTTGGAGGGC
TCTAGTCCTG
CCACACGCCT
TTrATITrCCCT
CTCTGGCACG
TGGTAAATTC
'TTTAAAACG
CTCCACT'TC
ACCTAAAGAT
ATrGAGCTAT
TTTCTTAAC
GGCGAATT
TTCTACAGGC
120 180 240 300 360 420 480 540 600 660 720 759 INFORMATION FOR SEQ ID NO:11S4: SEQUENCE CHARACTERISTICS: LENGTH: 258 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1 .258 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1154
GCGAGGATCA
GTGTGTTTGA
GGTITGTTAT'
AGTTTG AAAT
GATGAATGGG
TCCTI'GATAA ACGCATTAAA ACGCT 'AC TTZ YTTG G GCGTOAG;TTT TACCAATAAG CCTCATTLGT GTTTTTGGTT TAGT1'TATCA GTGGCAAAAG AAACAAAAAA AAGAT'1'CA TTGACAGCGT TAGCGAATTA GAAAAGGATT TGAACATGGA
ATACCCAT
TCTTAATATG
TTrAGTGIA
AAGCGCTAAA
AGTAACTAAT
120 180 240 258.
INFORMATION FOR SEQ ID NO:115S: Wi SEQUENCE CHARACTERISTICS: LENGTH: 816 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO 6/O9122.
835 (iv) ANT I-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1 .816 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1155
TCACGGAGTG
CAGCCAGAAG
AGCAACGCGC
GAAGTGCTT
AAI'CCATTG
GAGCGCTT
ACCTTAAACG
ATAGAAACCA
AACGCTAACA
AAAAACAACG
GAAGCGAAAA
ATTAACGAAG
AATAACATCA
GATCATTATC
TGAAATGAA
TGAAAGAAAT
A'TITAGCGA
TGAG'TI'GGA
AGTGGCTGAC
?I'AGCGAGTrr
CTAACGCCGA
CGACAAGACT
ACCAAATCAC
CTAATAATGA
CGAACGCTAA
CCAAAGAAAG
CGCAAGAAAA
AAAACATTGA
CTACCCTAAT
CACTAACGAG
GCAAGTGGAA
'TTTrTAAG
TAACGCCGGC
TAATACGAGC
GAACATTAAA
TTTAACGAGC
AAAAAACAAA
AATAAGCAAC
TAATGAAATA
CGCTACAACG
AACCCAAGCC
TTI'rI GAG
CTACCTAACA
CTTAAAGC
TAAGCCTTA
AATGCGAATG
GAGAGCTITGA
ATGCATIGCCA
AGCGAAATTA
TATCAAATCT
ACCCAAAGCC
ACTCAAACGC
AGCAACAATC
CAAATAAACG
ACAAGCGAGA
TTTAA
GCGCTTrAGA
AATI'ACAAAA
AATGCATCGT
AGATTGATAG
AATTAAAAAT
ACGAGCAGGA
AAAAGCTAGA
ITIAAACCA
TTGAAGCGAT
AAGCGATAAC
AAACCCAAC
CCAATAAGCA
TCACCGAAGC
GATAAGCGAA
CGCTTTAAGG
TAGGATTA
CAGTI'TAAGA
GAAAGAATAC
AGTAACCAAT
AAATCAATI'G
AGCCAGAGAT
TACACAAGCT
TAATATCACC
GATAACTAAC
AGAAGCAATA
GAAAAAGACC
120 180 240 300 360 420 480 540 600 660 720 780 816 INFORMATION FOR SEQ ID NO:1156: SEQUENCE CHARACTERISTICS: LENGTH: 1329 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .1329 (4i) SEQUENCE DESCRIPTION: SEQ ID NO:1156
GGATTIGTCGG
ACCAAATrrG
GGGCAAATTC
CGCATCAAAG
GCTGAAAGCT
ATI'GATACGG
AAAAACCTCT
GGCAGAAGCC
GCTGATGAAA
TGGGCGATCA
GCGTGCGGAT
CGCTACGCTA
TGTTAGAACG
AAACTA'n'r
AAGATAGCGA
AAATTGAAAA
TGGGCGAAGA
CTATC7GCGTT
ATGAAACCCT
ATGGGGTGTT
TCAAACGGCA
GTGGGGGTCT
T ITTAGGCTT
GGCTTGCATG
GCCATI'GCA
GAAGCTCTGC
CTATGCGAAT
GGAAGTGGAA
TTTGAAAAA
AACCACTAAG
ATCCCGCTTC
ATrGATGACC
TAAAAATAGG
TGGCGAACCC
TTTAAAAGCC
CGGGAATTTC
AAAAACCGCT
CGATCTGGCT
ACGCAGTGAA
GATGCCTCAT
GAAGAAATG3A
AAAGCTGTCG
ATCTGCT'rAA
CATGATTTAA
T1'TCATTATG
AAAAGCTTAA
GCTTT1AGAGC
ATCACCTG
CTGGATI'TAA
GCGCACGCCC
AATATCAGCA
CTTTI'AGCGA
GTCTATGAAG
AA.AAGAAACC
AAGCCCTATC
TTAGGGCGT(G
AAGCGGCATT
TCGCTTTICAC
GGATCACTI'C
AACTCAITCA
ATCAAGACAC
GTCTAGTT
CGATGGAAT
CTTTAGAATT
ATCAAGTCAT
GCAGTTGTGA
TGGAAGAAGC
CCATCTTGAG
GAATGAGCAA
GAATAAGCTI'
CAATCTTGAA
TACTTGCGTIG
TAGCGA'rrGc AAA.AGGCG?1'
GCTAATGGG
AGCTC 171 M7
TATCAGCGTA
AGAAGAAITA
TCAAAGAGAC
AAAAATCGCT
TTTTCAGCA
CGAGAATATC
120 180 240 300 360 420 480 540 600 660 720 780 840 IPENIUS i'01 lEC'696 ACCGGGCTrTr
TGGCATIGAAA
ATCACCAGCG
CCTAAAAAcA
TI'ATTGGAAT
AAT'GCGATGA
=III ITI A A
ATCAGAGCAT
GTG'TrGGA GCAGGGTt3AT
GGGACATGAG
A'rrrCATGCT
TGCTTAAAAA
TGCCTAAAAA
AAATATGGGA
ACGCCCTACT
GTTTGATTA
TCGCTCT=~
cCATAGCTCT
CAGCCGTTTG
TTTAGCTI'TG
AGGTTTGAGC
GGTTTTGCAA
TAACGATGAA
CAGCTAT AC
ACTACCCCCA
GTGGAGCGTT
AATAGCGTGA
AGTC*GGGGGC
AGAGAAGAAA
CAAGGCGC1T cGcT rGAAAA
ACTAAAAATG
TGCTAGAAAA
TGCGCTGCC
TTGAAAATCT
TAGTCTWTC
GCTAT'TCTAT
TTAAAAACGC
AATATTTGAA
TGGGGGCGAT
TGTCGCCTTA
TGATCTGTTr GGTGGTrAT
GCAACGGGTG
CGTIGCAAGAA
TGATCGAAAAT
TGAGAGCGAL
TTTAAAAGG
900 960 1020 1080 1140 1200 1260 1320 1329 INFORMATION FOR SEQ ID NO:1157: SEQUENCE CHARACTERISTICS: LENGTH: 291 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (geflomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc..feature LOCATION .291 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1157
AATGATAGTG
TI'GAOCCGCA
AAOCCCATGA
GAAATAGATA
ACCCACCCTA
GCTCAAAACA
CACGAGAATA
TCAGAGCCTI'
AAAATAGCAC
GTATTAAAAA
TTI'CATCTTG
CATGGCCGAT
ACAAAAGATI'
CCGATCAGCG
TCGTATCCAA
CC TTTTAA.
AGCGGGGCGG
TCTAACGAT
GCCTATCI'T
TCCTTAAGAA
CGCTCCTTT
CGTTIAAT
ACACCAACAA,
TTAACGCTGA
AGCGTGTGAT
GcAAATGTAT
GCATGACAAT
CGATI'ATAAA
AATGTTTAGC
C
120 180 240 291 INFORMATION FOR SEQ ID) NO:1158: SEQUENCE CHARACTERISTICS: LENGTH: 540 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc..feature LOCATION 1 .540 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:11 58 TCOAAAAAT TrITCAACCA ATTTTrTAA AACATCGGCG AAGACAAGAA TCGAGAAOGT PCT'V96/091?.
IPENIUS 18DEC 1996 TrGAAAGAGA
GAAGATCCTA
GTGOCTCAAA
AATATTAGCG
CTCATIAAA
GAAACTTrG
=TGCATGA
AGAGGCCTCT
CGCCTAAAAG
dAGTGGCTTTI
ACATTGAAI'
TGGGATATAT
TTTATAGCAA
ATGAAATCAT
GCATGCAAGG
TCAAA.AAAGA
GGTTCAAGAA
AAAAAGCGCG
TTACTCCACT
CCCTAAGGAA
ACOcCTGCAA
AGAGCCAAGG
GGTGCAA.AAG
CCCTAAAACC
TI'ATGGAAAT
TAITTTCAAG
TGCGAGCACC
AAGATTGTAG
ATCCAAGAAA
GGCGTIGATCG
CAAAATGCGA
AGAGCTGAAT
TCTrGTATAA GcGTTI'GcGA ATr CTCCC
GCATTAGCGC
GOCTGACCAC
TGG7I 1'GTGA
TCATAAAAC
TTATGCAACT
AGGCTATAAA
TGAAATGATA
'T=I GG
GATCGCTAAA
TCAAATTGCA
ACCCAAGCAC
AAGTGTGTTA
cTTAAAATCT INFORMATION FOR SEQ ID NO:115 9 SEQUENCE CHARACTERISTICS: LENGTH: 924 base pairs TYPE: nucleic acid STP.ANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (geflomiC) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION I1.. .924 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1159 GTTATAAITC TAGGCATGAG
TAACCCTAAT
TTrGAAAGCT ?TI'AAAAAA CCATTATTrA AAAGcCTI'1T TrGAAATGGT GC~rAATGGG GCCGTGCTTT GCTCTTTAGT
GGGTAAAAAA
AAAATCGCTr TAAGCATTGA
ATGCTTGCAC
TGCATGGATA ACGCTATITT
AAGAAGAAAC
ACCACAGCCG TTrTAATCGG
CGATGCGCTC
TCTTTACTAG AAAGCCGTAT
CATTGTGGAA
ATITAAAGGCA TGAfTI!TAGG GCAGGCTI't TI'AGAGCAGC TCACTTTCTT
ACACGAGCAT
ATTATG;GGGC TT'GTrGCGAG CGGCATrAAC TTj-GGGTAA AAATWGGTCT I'rGTrTTCAA GATGAAAAAG AAAGCGGTAA
AACCACGCAT
TTATTGGGC TAAAAAAGGC
AAGCGGTTAC
GATITGAATG CATI'AGAACC
TACTIATCTT
AACACTCTAT TTAAAGGCAA
GACA
TTATCC JILr
CACCTTGAAG
GGCAAAAGGT
GATITATfCTA
ACTTM'ITCGC
CACCCCACI'
AACACCTATT
TrAGTCAAAA
GATTGCTATT
AAAACCGCTA
GATGAAGAGC
GTGCTAGATG
TTAGACAGCG
GCCCAAACTT
TCATTGCAAG
ATrGTAATGA GTGCGAGCGT GCTTCCACCC
TTATI'IGGAA
TCCGCCCCAA Gc~rrrrI'A ACCAACAAAC AGAATATTr TCATCCATGA
CGATI'IGCCT
TACACGCCAA
ATACGATGAA
CTI'ITGAATI'
GCTCTCAAAT
TCTTAAGCGC TAATGGGGG TTGA&AAACAC CCCCI'rAAAT AATrGATTAG
CGCAAGCCTG
TITTTAAAATG
GCTTCAGGCT
ATATTATAGA
CGTI'ACACAA
CTAAAAACAG
CTITGTGAAT
TAAAAACAGA GAT1'IrAAAC AAAATTAAA CGCATrATTG 120 180 240 300 360 420 480 540 600 660 720 780 840 900 924 INFORMATION FOR SEQ ID NO:1160: SEQUENCE CHARACTERISTICS: LENGTH: 1041 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE: NO PCTUS 9 6/ 0912.
IPENtUS o. E_ Q 0 83S (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .1041 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1160
CTTCTCAATA
GI'ATGCGAG
ETTGAAAAGA
GCGATT'TG
GGTATAGCCC
TTTGTGGTGG
AGCGGCGAG
ATCCATCGCC
TATATCATIA
C'ITATCGCTC
ATCGCTCATG
ATTGAGCA
CGCAAGAATA
CC'T'?I'AA
AGCGGGGCGG
TCTAACGATI'
GCCTATCTI
TCCTI'AAGAA
CATCAAAGAA
CGCGCTGCTC
TTATCGCGCA
CTITITATTGG
Trrrl'AAACT CTrI'I'GTCAT
AATACAAGCT
TTTGTAGA
ACGCCCCTA
T'TACAAGCGC
AGCTCAGCCA
ATATCATGCT
GCGGGGCGAA
CGCTCCI '17
CGTITAAT
ACACCAACAA
TrAACGCTGA
AGCGTGTGAT
AAAGCGCAAT
AAAGAAATCA
AAACAGGCTC
GTTG7I'GGTG
CATGACTI'
TATTCTIGI'
TATTGACCCA
GC ITrI7AGAA
CATCAACGCT
TTI'AATAGAG
CATACGGCAC
AI'GGTGGCT
TTTAGCCCGA
GCAA.ATGTAT
GCATGACAAT
CGATTATAAA
AATG'TIAGC
I GAAT rGGA
AGCATGAGAA
AAAACGAACG
GATGCTATTA
CAAATTC
TGTATCCAAA
AGCAAGGTTT
GAGGCTAAGC
ITTGCGAGCG
AGGTTAGATA
AACGACATCC
AA'TrrAGCG
ATGATTTTAT
TTGAGCCGCA
AAGCCCATGA
GAAATAGATA
ACCCACCCTA
ATTTITACI'G
AGGAGAAAAT
CGGT'TrTAAC
GAATCAACGC
CTACGAITAC
ATI"ITAGCTC
TAAGCTCTAA
TTCATTIT1A
GGTGGGATGA
GAGACGAATI'
GCTTGACCAT
TGTATITI'?I'
GGGTTTTACA
CACGAGAATA
TCAGAGCCTT
AAAATAGCAC
GTATAAAAA
CCTAAAGGGA
AATGACGAAT
CACTI'ACTGC
TAATGAMTA
TAT1'GTCATG
TATCATGTITA
AGAAAATCAA
GCCTAAGCT1'
ATCTAAITCC
AAAAGCCGTG
GTGCGT GGGG
CATGGGGAAT
GATCATCI'G
CATGGCCGAT
ACAAAAGATT
CCGATCAGCG
TCGTATCCAA
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1041 INFORMATION FOR SEQ ID NO:1161: SEQUENCE CHARACTERISTICS: LENGTH: 195 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .195 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1161 ACACAGCCAC ACAAAAACAA GAGATrAAAC AAGAGA'I'IAA ACAAGAGATT AAACAAGAGA TI'AAACAAGA GATTAAACAA GAGATTAAAc AAGAGATTAA ACAAGAAACT AAACAAGAGC AAGAAAAAGA AAATAAGCCT AAACAAAACA GTGTCTCGCC CGI'rCAAAAC GATCAAAAAA CCCCCACAAC CCCCT INFORMATION FOR SEQ ID NO:1162: Ci) SEQUENCE CHARACTERISTICS: LENGTH: 414 base pairs TYPE: nucleic acid _7 STRANDEDNESS: double Z TOPOLOGY: circular POUS 96/09122 IPENS 18DECiS99S 839 (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc..feature LOCATION .414 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1162
GGGGTAAACA
AAAAACACCG
CCAA.AAAA'T
TTTrTATCGC
TATTGTATT
TT GTAGATA
TGCGCTAAAA
TGCTTATITTT
ATGCTATITCA
TGGAATTAGC
ACAAGATAGA
TTAAGGATAT
GCAAAATCTI'
ATCAA.ATAGA
AGGACACCCT
TTCCAGCGCC
CCAATATTGC
GACGGACACC
TAAGCAAGCC
GIICTATG
TGGTGTCATT
TTAATCCCTA
AATAACGATA
TGTGAAAATG
TrTTrTAT
ATACTCGCCC
GATTTTAACG
TCTAAAGAT'
GCGCTCGT
TAGTGTGIT
GCGTCCAI'T
TCAACGCTT'
AACAACACGC
ATACAGAGTC
CACTCCTITTT
TG'TrTCATI'
TGAAGCAAAC
TAGCGTGATC
CAAACCGCTC
CACTAATTAC
ATGGGAGATI'
GAAA
120 180 240 300 360 414 INFORMATION FOR SEQ ID NO:1163: SEQUENCE CHARACTERISTICS: LENGTH: 402 base pairs TYPE: nucleic acid STR.ANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc..feature LOCATION .402 (xi) SEQUENCE DESCRIPTION: SEQ ID N0:1163
TTTAAATGCA
ACTATGAGAA
GCTGAGCATG
ATTACGGAT
GATAACCGAT
GTCATrACGA
GTTGAAAG
ATCTTAAAAG
GAATTATrAA
GGGTGGAAGC
GGAACATGCC
'ITAAGGAAAT
CTTTrAAAAGC
AAAAATI'AGA
GAGAAGTGCT
AAACACACTT
TTGGGAAAAA
TGAAATGAAC
CCCTATCATT
GGGCGTGAAT
GGI'GTTA
?'rGAAACTAC
TCACGCTTAG
CTAGACGCTA
GGGTTGGATC
ATGATCACCA
AACTACAT'M
GGGACAAACG
TGGTAGTAGA
GCTATGAAGA
ATGCGGACAC
TCGTTAAAAA
CAGAGGOCG
TOMAACCI'r
AT
TOATAGCTCA
TGTTTTAGMA
TAAGGTGCTD
GGTGCGTGCG
TAAAGCTGAG
TACCCCCCAA
120 180 240 300 360 402 INFORMATION FOR SEQ ID NO:1164: SEQUENCE CHARACTERISTICS: LENGTH: 840 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular POT/US 96/09122 IPENUS IS8DE2t"iJ96 840 (ii) MOLECULE TYPE: DNA (genornic) (iii) HYPOTHETICAL:
NO
(iv) -ANTI-SENSE: NO (vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc...feature LOCATION .840 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1164
CGGGTTATGG
CTCGTATCGC
GGGGCGIT
GCG'rTGTCGG
GAAGCGAGCA
AGGCTGT'IG
G'I GTAGAAA GT rTGGGTGC
GTGGATGCGT
ATITT'AGGGG
CAAAACTCAC
TTAATTGAGA
GCCITGTGA
ATGGTGTGTA
CGGTGCGAAT
TCTTTTI'AAG
ATGGGCTAAA
CGTT'TGTTTA
GCACGATT1' cGAATGAAAA
ACGGCAAGCA
CAAGCGGGGC
CTTI'GATCAG
GTATGTGAA
GCCTI'CTAG
GCAGCGCGAA
GCTTrrAT'r
TTAGCGTGCT
cATGGCGACG
CTTGTTGGTG
AAATIGGCGT'
TrCCCTI'TAT
AACGCTT-GTT
ATGTCTGGCC
GATAGAAAAA
TAAAATCGCT
CGGGGAGTT
CGTGGGCGTG
TTTGCTAGAA
TAAAATCGCG
GTGGCAATT
AGTCATAAGC
GTATGGACAA
CTAGTGGTGG
G GGCATGG
GCGATGTTIGG
TrI'GGCTCTA
CTAGAATCGC
CACCCTAAAG
TI'AGATGGCG
AAGCCT'rTGG CC rI'AGCT
ACTI'AAAAA
GATA TTI' GGITrGGGGG
TGCCCTTGCG
ACTCATGCAA
TGGGGCGTT'
ATTTGAGCGT
TGTCTCAAGA
AGTTIGGA
ATGAAATCCA
ATGTGOCGAT
TGCTrTAAA
AATTGGGGGT
ATCAAGTGAG
ACAGrII1'T
CTAAAGCGGT
GTAATT1TGA CGTTrCGCTCG
GGAATTTGGA
TTI'CATI'AAG
GTCTTIGGG
GACCTA II'
ATTAAAGGCT
TAGCGTGATC
AGGCTCGGTT
TAGCGCGAGC
TAATGATCCA
CGCGACCTTI'
AGAAAAGCCC
GTTGI'ITrA AAAAGCTtIrA
GCTACGCCCA
120 180 240 300 360 420 480 540 600 660 720 780 840 INFORMATION FOR SEQ ID NO:1165: SEQUENCE CHARACTERISTICS: LENGTH: 588 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISH; Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-.feature LOCATION .588 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1165
CGTGCTAGTC
GGGGTGTTTA
AAAGTGAAAA
AAAGAAAAAA
AGGGAGCATT
GAAAAGATAG
GTGGGGAGI'
AATATCATGG
ATAAGCTGCC
AAAACCCTT
AAATCTTTAT
TCATTCATGA
TAGCCCATAA
AGTTICGC
TGAAATTTTT
TAGGCTTTGC
CTAACGCTAA
GCGGGGATAA
CTTGCGCGT
GATCGTGTTT
AGACAAAACC
AGAPLTTI'GAT
TGCGATTCT'
TCATGGCCTG
AAACGCTATG
GAAAAATAAG
AGAAGTCATT
TGAAAGCTCG
CGCTCGGCTA
AAAGAAGCGT
GGCACCCTCA
GAAAGGCTrr
AAAACATTAG
AAAGCGAGCT
GGGGTTGAT
ACcTTATGCG
CAGGCT'N'AC
GTTAAGGAGT
CGCCCATAGC
TGTITTI'AGA
CGCAAAAAGA
TAAAGAGCCT
ATGGCGATGA
ATCAAAACGA
TAAAGGTTAA
CGTTATTCAT
AAAATCAAGG
GCGCGAAA
GTTAGTOATA
AACTCTGGCT
AGTCCT1TI'A
'TTAAAAACT
GGTTGATII'G
AACCTTGCTA
AGAGAGCGCT
TT'rAGAAGAG
CTTGGAATTA
120 180 240 300 360 420 480 540 588 PCT/iS 96 0912?2.
IPEANS IUDL_0 .3s9 841 INFORMAT ION FOR SEQ ID NO:1l66: SEQUENCE CHARACTERISTICS: LENGTH: 2001 base pairs TYPE: nucleic acid STRANDEDNESS: double .TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .2001 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1166
ACCCCAACCA
TCATGAGTA
ATITACATCA
CAATTAAACA
ACTTCTATTG
TTIGAAAGTCT
GAGGTCGCGA
TTGATCCGTI'
GATACCGGTG
TATATCCAAT
TTAAAAATCA
AATCTCAACG
ACTI'ATAAGG
GATGTGAAAA
TTGATTCACA
CTGCATTTCA
TrTTGCTCA
ATCGCTATAC
TTOCAACACA
AAGCATGTGG
ATITTTCGCGC
TTTGCCATGC
CTCATI'AAAG
ATTTATGGCG
GTCTTAGGTI
CAAATCAATG
ACCGCTI'rAG
CAGGTTTITG
ATAGAAACCT
GAAG'I'IAGGG
TACCCCATTC
AAGCTCTATG
CTCAAAACCC
AAGCCCCTAA
TCGCTAACAT
TI!AAAGA
GAGTAAGCAA
GCTGGGCGTA
TGCAAGATTT
GCGTGGGGGG
ATAACTTGAG
GGGGCG?1'AT
CTTTAAACGA
AAGATATAGC
GCGATAAGGA
TGCTI'AAAGC
TCACCAGCGT
CGCTCATAGA
GGAGCGCTTT
TGCGTrAT1'r
GCGATOOGT
'TTGACACGAG
GGGGCGCGAT
TCACCGGTCA
TAGTGGGAGC
GGCGGAT1TI'
TGAGTI'TGAG
TAGGGGGT
AAGGGGTAAT.
AATATTTGAA
GTAAAGTGGG
ACATTGAATTI
ACAAAI'GGA
GTGGCAGAAC
GTAACGACAC
TCAAAGAGAG
AATCGTGCAA
TGACACGGTT
CGGCGTCAAT
TCTGCCTAAG
TCAATACGCT
CTAI'ACCOC
CTITGTGAAG
IWITAGAACAA
TTTAGAAAAC
TTAGAAGAA
GAGCGTTAGG
AGTGGTGGGC
CATTAAAGAA
GTATGACAGG
AGAAAGCGTC
AGTGGTGATr
CAATATTGAA
GGATGCGGCG
AGACAACACT
ATI'TI'TGCC
AGAAGAAAAG
GCTGC'm'rCT
AGAAGAGTCC
GGTGTGCTT
AGTTGTAGCG
CATGTATATC
AAAAAGTAAC
GCGCGCTAAC
AAAGCCGCAA
AAAAACCCTG
GGACATGCTC
GGACAAATTA
TTTGTCCGGC
GAGCAGGI'A
AGAGGGATT
TrGTAFrGGG
GACGCTAAAG
TTATCTAGCG
TATGCGCTTI'
GAT1'ATGAAG
GTCGCTAACG
GGGTTTCAAA
ATI'GTGGTTA
CTAGCGCCCA
GGGAT1'GTITA
AAAATCGCCA
AGCGAATTGA
ATTGTGCTAG
ATCACTCTGC
GCGAGCATCA
ATAGTGATGG
CAAAGGGTITA
TTAATIGATCA
CTIWITTGCCC
ATI'ACGATAG
GAAAGCCCCG
AAGTTCAGAT
TATAAAAAAC
CCTGTAACTA
GCTGCTATCA
ACCAGCACCG
AACGAATGGA
CAATTAAAGG
TrAACCGGCA
CAAGAATG
TTTGCCGAGC
CTTACCCGT'
CTAGCTATGA
CTAGAGATAG
TGGAAATAGG
ATAGCAAGAA
TGGGGGTTGA
TAACGC?1'CA
CGATI'AAAAA
AAATI'ATAAG
AAAAAGAAGG
AACCGCGCAG
TGGTGCGCTA
CCTI'ACAAGC
TTGAAAAAGG
TCATTATC
CTTTAAGCGT
TGAGTICGG
TIGGAGAACGC
ATGCCATCAT
TCGTIGGTTTIC
CTTGCT
TCCCTGTTT
TTAACGC?1TT ACGCTTTTII1r
TCAACTGGA
TTAATGGCGT
AGCAACTGGA
ATOGCCGCCGQ
AAGAAAAGCT
GCTTGACTAA
TTIAGAACCC
CGATCCTTAT
GGTITICTACT
AAGCGGCTTG
GGTrI'TAGAG
GAGCGATC
TTI'AAGCGAT
TG7GGGTGAGT
AAACGATTCT
TTCCAATAAC
ATCGCATGGC
GGCTATCCCT
AGGGGCGGCT
TCACGCTIGAC
GAGTAACCCT
CATTOACAAT
GATI'TTCTI'A
GTGCATCAGT
GGGCATZ'GCG
TCACAAGCAT
GCAAGGGGTr TrrcTGCCT
CACCAAAACC
AATGGTATGG
TTTCATGAAA
AATAGCGAGC
ATT'rATCCCC GGGTA?1'GAT
TTTGTCAAA
TTTAGGAATG
CAGCTATAAA
TTCATGGACT
CCTAGGCATC
GGAGCAACAG
120 180 240 30 0, 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1140 1200 1260 1320 1380 1440 1500 1560 1620 1680 1740 1800 1860 1920 1980 2001 GATCCAATAA CGGCTACTAC ATCACGCTGG ATTTGGAACG A INFORMATION FOR SEQ ID NO:1167: SEQUENCE CHARACTERISTICS: LENGTH: 285 base pairs 77 TYPE: nucleic acid PCT/US 96/0912.2 IPEAIUS i 6 9&" 842 STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .285 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1167
CGCAACGTGG
GTTITTACAAG
ATCAATGCCG
CAATTGGCTA
AACGCAAGCC
AAGCGCGI'A
AGTTCGCTCA
CTCGCAGTCC
AAGAAGTGI'
ATTTCGCI'C
TI'ATTATGGG
CTTTGGATCG
'TTTAAGCACC
IiGAATT G
CAATTTAGGA
GACACI'CAT
AATGATGTGG
TATGCAAGAG
GGCGTGGT'I
ATGAGGTATA
ACTTTATTT
CGTCTI'TAAA
CGATCATGGG
ATI'TGCACAA
GTI'TC
GCATGCGGGA
CACCTTTAAA
TGGGGAATTG
TTTGAlTTTCC INFORMATION FOR SEQ ID NO:116S: Ci) SEQUENCE CHARACTERISTICS: LENGTH: 633 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION I1.. .633 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1168
AAACCTACCA
GCTTCATGT
ATTGTGGGCG
AACTCTGGG
GAATI'TGACT
AGCACTCTAT
AGAGCGAGT
GTGGGCGTGA
GTGGCTI'TAA
CGCGTTA7'A
TCGCTCACTI'
ATGTTTIGGGC
ATGGCACAAG
GTTTTGGAAG
CCAATAACGC
TTGAAGCTCA
TACAAGATT
ATGGTTATGA
GCTATAACCA
A.AAATGGCGC
TrATGGGGAC
TGGATCGAAT
TAACGCTATT GGGGGAGCGA CGCCGGCGTA GACGCTTI'CC
CTATGGTTAT
TAAT'TrGrGC
AGGGGCGCTA,
GAATCAAAGC
CTTCGCGTIT
TTTIAGGTTCA
GAGCAGTCAG
AC7I'CATACT
GATGTGGCGT
AGCTCCTTTA.
GTGTATAGCC
GGGAGCGATC
TATAATI'ACT
TTTAGGAACG
ACCAACT 'IA CATrTATTCA TTTATr'rGCA CT1' GCTT GAATAG
TTAACGGGAA
GCAATCAAGC
GTTTTTTrC
AATCAAGCTT
TAGCCTATAG
CT1'TAGTGTT
AAAGCAATAG
ACGCTAACGC
TGCGGG0AGTT
CGGCTCTAAC
TGTG3GAAGCC
GAACTCTCTT
CAACCACCCT
GAATI'rCAAA-
CGCCACAGCA
AAAACCAAGC
CCAATCACAA
AACGTGGALG
TTACAAGAGT
120 180 240 300 360 420 480 540 600 633 INFORMATION FOR SEQ ID NO:1169: Wi SEQUENCE CHARACTERISTICS: N LENGTH: 234 base pairs PCI/US 96 0912.2.
1PEA/US j.6 LujU 6 843 TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circul-ar (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc..feature LOCATION .234 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1169 AATAAAATCC TAGCCAGTGA GCTAGAATI' AAATTITAA TCAAAGGAGT CATCATGGCA CACCATGAAG AACAACACGG CGGGCACCAC CACCATCACC ACCACACACA CCACCACCAT TATCATGGCG GCGAACACCA CCATCACCAC CACAGCTCTC ATCATGAAGA AGGI'GT GC AGCACTAGCG ATAGTCATCA TCAAGAAGAA GGTTGTTGCC ACGGGCATCA CGAG INFORM4ATION FOR SEQ ID NO:1170: SEQUENCE CHARACTERISTICS: LENGTH: 1035 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1035 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1170 GGGGTl'TTXA TI'AGAACCCC TACTACACGC CCCCT'rATIT ATIGAAAACT ACACGCTTr1' CACCCTAAAA AAATAGGAGC CTAGCCAATC CTAAAAQAGA GGCAATCCCC CCTATAACGA TrCATI'ITIG AOATAGACAA.
TC TI'rGCAA ?I'TTAAAGCC AAAGAAGCTA AII'rAAGCA TTGTGTI'T CTTCTAAATC TATGAGCGAG GGCGAATGGA GATACGACGC TATGCTTAAA AACGCTAAAA AGGTTGGGGC CTCAAACGCA ACAAAACTI'r GATAAATGA T'ITAITACCA TATTA'IrrG GTAATr
GGA
ALCTTTAA AAGATAAAAG
CAAGCATTA
AGTGGATTOC
AGACACCGCA
GGATA I3AC
AAATTATGGC
TAGAACTTCC
CGATI'rGAAA
GGCGVTTATT
ATTAAAGCTA
?1'TCACTAAA
CTATGCAGGT
CGATTTTGAC
ATGCGTGGGC
ITI!AAACGCG
ATATATCCAT
TATTATCATT
AGCGCGTTA
ACCAAGCAAG
GCTTACAAGC
TGTGGTAATA
CCTAAGTGTG
ATTAGCCAAG
TI'rATCAAAC
TCCCGAGAI'
TGCGTGCTAC
rTTAAGGATC
AGTAACGAAT
AT'TAGGCGTT
TACATAGCCA
TATITTT'ITC
CCAAGCGAAA
TATTTTAAGG
GATCATTG
GAATATTTTA
AQAGCGTGAA TZTTAGGGGCT TTAAAAAA GCAT2G AAGAGTTTlT AAAGCTCCAC ATGC'TrTAAT AATAAACGCT
ATGAACCTTT
AAGATATI'AA
TAGGGATAAG
ACCC
4
I"I'ITC
ATTACAGGCT
TI'CCTATTGT
TTGTrrTvrCC
ATI'ATGTIGGA
CTATGCGAGA
ATGCGGTGCG
AAATTGCTCC
CTTT1TTAGA.
AAAAATTGTT
AATCATCGTG
AAATAAAGAT
rTMT rAAAA T'rATCTCATC
TTTAGACGCT
GATAGCTTTIA
AACTGAVI GC
TAAATACCCT
CATTAACGCT
AATCAGTCAA
TAAAATCCCT
AATI'AAAGAC
TCAAGGACAC
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 POUS 96/0912.2 1PENUS 18[jEO1996 844 ccTI'GTGAGT TTGAT INFORMATION FOR SEQ ID NO:1l71: SEQUENCE CHARACTERISTICS: LENGTH: 786 base pairs TYPE: nucleic acid STRANDEDNESS: double CD) TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .786 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1171 1035 AATATrrAA AAAATG TT AAAAAAGTGA TrGAGGI'rC ATCAGACATG CCTZ AGCGA TTAAAGCATI' ATOTAGAGTOG TTrGAACTCA CTACTTTAAA AAAACTCT?1' ATGAAITGAG TTAGAAAATT TAGAAAATAC AATTATGA TTACAAGAGA CTCTIACGCA TTTCTI'ATCC ATAGTTATA AGGAACAACA TCTAT7TGG AGTTAAAAAC CATGCCCTII' TGATTATCCA T GGAC TAAGCCAAGT
CAAAAT
CAAGGACACC
TATTCCTTTIA
TrATGGTATT
GCAGATCGGT
AGATGAAAAA
CGAAATGATT
Trl'AAAATI'r
AAGATITAGA
?I'TGCTCATT
ATATGGCTCT
CGCTACCCCC
TGAAACCAAC
GCACCATAAC
CTTGTGAGT
ACTTCCM'rI'
TCAACAGCGA
TATGATGTCC
TATCATTI'
TAI'ACGCTA
T1'AGAAAAAC
TCGCATCAAT
CATTCTITTTG
AAAACCCAAG
TTATTAAACA
GCTCTTGTGT
GATGTGTI'AA
T'GATTAAAGT
CAGGCAAAGC
CTAGAAAAAT
CCAI!AAAGA
TAGGGGCTAA
AGCGATTGGQ
AAAAACAATT
TTGGTGGCAT
ATGATAATGA
CCATGCTGTA
GAACCGCTAT
TTTTAGAAAT
AGATTAGA
TAGTGGTGAT
GCGTGTGAAA
CCCT1AG7
TAAAGAAAAA
TAATAAAGTA
'TTTAATCAGT
TATAGAAGAT
GGATTI CAA GT1GAGCGAA TTrTGCTrr
GCCCAAAGAA
GCTTAAAATr
AAAAATACTI'
120 180 240 300 360 420 480 540 600 660 720 780 786 INFORMATION FOR SEQ ID NO:1172: Ci) SEQUENCE CHARACTERISTICS: LENGTH: 1239 bass pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: CA) ORGANISM: Helicobacter pylori (ix) FEATURE: CA) NAME/KEY: misc...fature LOCATION .1239 t xi) SEQUENCE DESCRIPTION: SEQ ID NO:1172 POT/US 96/0912.2 JPENIUS i8 DEC 1996 T1'GAAGGCAT
TATTCTTTAA
GGA.ATGGCTA
cToTTAGGGT
CAAGATAAAG
GCAAATAACA
TACAAAAAAG
AGAACCCTCC
GACCCCCTTT
CTAGTGAAAA
'ITTGGCCAGC
TTT1'CCCAT
CTAGAAACCC
CCTGTFI'rAA
TTGATCCAT
AAGGTGGTT~G
GCTAACGGAT
AGCACGGGT'
ATTAATCCTT
G'I*ITIAG
TCTTTTGAAA
-TAAACGACTG
TGGTTGCTTr
AAAAGCAAAC
T TTTAGAAAA
AATTGAGTGC
CGCTCA'rrCA
GAGAGGATA
TTCTTTCCTT
TAGCCAACCA
ACGATAAAAT
CGACCATCAA
CAAACGGCCG
CGGTGAAATA
AAGTTAAACG
CTGCTI'CAG.A
AAATCCATT
TAAAAAAAGG
TAAGCACCGG
TAGGCTATAT
AAAAAGCTCA
AAAAT'CAT'
CATGGTATT
'rr'1ACCAT TCTI111IAG7G
AAACCATATC
TGAAATCCAA
AGCCCTTATC
1TIITTAGAC
ACAAACTTCG
ATTGATGAAC
CGCTATCGT'
AATGGCGATG
TrATI'ACGAT
CACCCCCAI'
GCCTCATI'AC
CGGCCGTGTG
GAATGAAT'G
CTCGTTCGTT
GCCGCATT'G
CCGCACCGCT
GTATI'CTAAG
TTATCTITTA
TITTCATAAGA
TTATCCTATG
GGTGAAAGGC
CCCCAAAAAC
AGCAATGTrA
CCTATTAGCC
TTTATCCCCA
CCCTATCAAG
GCGTATAAAA
TATACAAGGG
GTTAGCTCTC
TCAAAAGCGC
TC'I'ICGCCT'
;CGTGGATr GG'FITrATAG
CGCTI'GGTGT
AAAAAAGGGC
CAT7ITGGCG
AAAAGCAAGC
CAAAAATTAG
GAGGG'TT
AATrA~rrr
GCGTTCTTTT
TTGTGTGGGA
TCTACTACAA
CCTACTACAC
AGGATT TGCA
TTGTTTTCAC
ATATTGTCAA
AAAGCGTGCC
AI'ATCGTGT
GTI GCACCA
AAGAAGTGGC
TTTICGTATGG
ATGCGGCTAA
GGGTTAAGGC
ATGCTCACAT
AAATCATAGG
TGTATAAAAA
TGCATG3GCAA.
AAGAACTTTT
AAATITATC
AAAAGCCGAT
TAAGCTCACG
TTGAGCTCT
'ITTAAGAGAT
AATCCATATr
TCGTAAAGAA
AGCCACCAAT
ITTTAAACGC
GGGGCAAGCG
ATACTATCTT
AGGGTTI'IA
GAGGTrCCAT
ACATGGCAGT
GGGTTATGG
GAGCGCGTTC
AAGAGTGGGA
CTCCCGCCCC
ACAAAGAGAG
TAAAACCCAT
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1140 1200 1239 INFORMATION FOR SEQ ID NO:1173: SEQUENCE CHARACTERISTICS: LENGTH: 759 bass pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .759 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1173 GGATGCT1'GA
AAAAAATTWT
TTGCACATCA
GCCCCCAAAG
CTAGGCACT'
CCTAATATCA
GTAmTAGGC
TGGTIWTCAAA
GAACTCATCT
TCTCAAATrT CAGCCTflTrA
AAAGATI'ATA
AACGCCCTGT
TGAAAAGCAT
CACAAGATAA
TTAAAACGCA
AACATI'CTIG
ATITI'I'3CC
ACCCCTACCA
ATATl7CTTTIG 1'1TATAATG3A
ATGTTTATCC
GGATAGGTTG
ATAAAGAAGG
ACGGGCAAAA
GTTrCGTTTG TTTGCTCTTT ATGATTTTTG T1'rrAAGGTG AAACGATrrT3 GGr 2A 'II'
TI'TI'ATCAT
ACGCAATQGAG
GACTAAAGGC
CCCTCAATCC
TATrAATI'T
GCAGCACATT
TAATCCTGAA
AGATGTGCGC
GTGTGGGAAA
GATITATAACT
TCCAATGCCT
GCTAAAAAAT
AGTrrCACCC TTTDAAGT1TCC
ACGCTTTATC
GCCCCCATOC
AAACCI'I G
TCTAATGQTG
AACCAGTTTC
TGGGGGGGGT
AGGGAGGCC
TAGTI'TGTCA
ACTATITTQCG
GGTATCTCCC
ATTTAAACAT
CCATTTCA
AAATCAGTT
TGvGCTTATAC
GAATGATCAA
GGGGTAAAAT
TGGGGGGTGC
CAGGACAACC
GTCGTTCGGT
GTTAGAAGGC
CAAACAGGAT
TCCACAAAAA
GATG3GATTAT
ATGGTACCAC
TAGAGTGCCT
CCAAACTAAC
TI'TCATGCCT
AGGQAATT
GCAATG?1'AC
TGTAATCGI'
GAGCGCGGGC
120 180 240 300 360 420 480 540 600 660 720 759 INFORM4ATION FOR SEQ ID NO:1174: N(i) SEQUENCE CHARACTERISTICS: LENGTH: 272 base pairs POT/US 96/09122 PEAUS 18DEC1996 846 IB) TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION .272 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1174
ATGTGAAATT
ATGATAGCTA
TTTTTAATTT
TCTTACTGCC
GGGATAGAAT
AAAGGGCATG
CGGCCAAAAA
TCTITTTGCG
CGTCATTGGC
CCTTCTATCA
GATAAAGAAG AAAATGAAGA AAATAAAATT AGCCCTTTCC AAAAGCTATG GATATTGTIT GTTTTAGTGT ATT TITTCT GGCATTGAGC GGTTTAGAAA AAAACGCGCT AGAAGCCGGG ACCATCAAAA AA
AACCAAGCGA
GGTGGGGCGT
GGGGAAAAAG
CTGTTAAAGG
120 180 240 272 INFORMATION FOR SEQ ID NO:1175: SEQUENCE CHARACTERISTICS: LENGTH: 279 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: mise-feature LOCATION .279 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1175
AGAATTGAGT
CTTTTGTTGT
CCAGCCTTAG
TTGCCAACGC
ATGTTTTTAG
GGGGTAATAG
TTGGGGCGTT
ATGGGGCGCA
CCATACAAAA
GGCTTTTTAA.
GCATTGTGGG
TTrATCTATC
AATGCTAGGG
TGCGTTGTGG
IGACATTACT
GCGTTAAGCC ATGCCAATAG AATCTAGGGA TTTTAAATrr GTCGTTITA AAAATATTTT CTAGTGGGGG TGGGGTIlTr
CGTTTGCTA
CGTGAGCATG
ATrACCCATT
TCATATCGCT
GGTITTTIGTC
INFORMATION FOR SEQ ID NO:1176: SEQUENCE CHARACTERISTICS: LENGTH: 1272 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) PCTUS 96/0912.2 IREAIUS 18 DEC 1995 847 (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .1272 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:l176
AATTTAGGCG
?TATGTGGG
ATAAGGATTIG
CGCATCATCG
AACGCTGAT'
GGCGTGATCC
ATCACGCTAG
AGCAAATAI'
CATTIGAAAT
TATCATATCG
GGCGAGTTAG
GATACGGTGA
TGCGAGTTTG
AGTTTIAGAAG
AAGCTGTTAG
GATATTCTCC
CTTGTGTGG
ATAGTGAGCG
GTGGTGTTTG
GTCAAGGGAG
CGTI'TGATAG
ACACATAATG
GAGCGGCCAA
TAGTGGGAGA
ACACTTCAGG
CGCAAAACCA
TAAGAAAGAA
TTTCAGATTIA
CTAATAAGCA
CCCATGCGAG
TAGACAGCCA
CTATOCCTI'
TCAATTGCCC
TAGCGTCTTT
CTAATGCGGC
AAATCGCTTT1
AAACTTTAGA
ATAAAGGGCA
GGTTAAATAG
AAAAAGACAG
GAGAAGACAC
CGGACTACCT
AATTTGAAGA
AT
TGTGGCTAAT
TGAITTTAAAA
TGT TTTAATA
GCAA.ATCGTG
TCTTTAGAT
CAATAAGGGT
TCATAAGCTC
TI'TGATCACG
TGCGAA'TrA
AGTAACCTI'G
CACTATCGCT
AACGCTCTCT
TGCGGCGGTG
GATTTGAAC
ACGCAACCAG
TGCGAGCTAT
CGATAATI'CC
GGCGTTTCTI'
GCCCATAAAA
CAATAAAGAA
AGGTTATTCC
AACCI'ACCT
GGCAAGCAT
GATAAAACCC
CGCGTGGATA
TTATCGCAG
GTGT1'GGAT
ATI'TATGCG
CCTAATCGCG
TCAAAAGCGC
AGCGAACAAG
AAAGAAGTTT
TI'ATTGGAAT
GTGGT=GTA
CAAACGCACC
CAAAAAATCG
TTGCAAAAGG
ATTAAAAGGC
TTAGCGAGCT
TGATCAAG
GTCATAGGGA
ACAAGCGCTA
CITTTAAAAGC
TCATTAGCAC
GTTGCACCAC
AGGAAATCAA
AAAAAATTCA
TTGAACTCAC
ACCCTAAAGG
CTGAATTAGA
TCCAAATI'
GCATCGCTIT
ATGATGTAAC
CAAAAAGCT'
AAATGGGGAG
CTAAAATCCT
T'TrCACCAA
CTAAAGCT
TTAAGGGGGA
TGTCTrGCGT
CCCTAAAGCC
GCGAGTTGGC
TCATAGAAAA
TAAAGTCITI'
TTrrAAATTICT
GCI'AAAACG
AGACCCCI'A
AGAAATAGAT
TCAAACCATC
AAAGGATTAT
GCAAGCGCTC
ACAAGAAACT
TITAGAAAAA
GGGGGCAGGC
GAAAGAAGCT
CGCGTrIAGCG
CCCTTAGAA
TG7GCTGTTr
AGGGGATATT
TAAACGCCCC
GGATTATGTT
TGATATTrA,
TAAAGAAACC
AATTAAAAGG
120 180 240 300 360 420 480 600 660 720 780 840 900 960 1020 1080 1140 1200 1260 1272 INFORMATION FOR SEQ ID NO:1177: Wi SEQUENCE CHARACTERISTICS: LENGTH: 963 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: No (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .963 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1177 GGATCGC?1'A TGGTGAATGT G'rITrTCAAG CAGCAAAAAT TCGTCATTAA.
AATGACTrI'A ATGGTITGA TATAGAAGAA AATGAAGTGT TGTGGITGA ~CCTACGCCCA ATGAATTAGC CACTCTAAGC CAAGAATACG CTATCCACTA ATTCCCAAC GAGTCTCATC AGT'rACCAAA TACTGGGAAG ACAGCTCCAG
AAAACGCITT
ATAATCAAC
CAACACGGAT
CGTTACGATC
PC i/$916/092.
IPEU~i8DnI9 1 AACGCT=w
ATTTTGTCTA
ATCCAAAAAA
AAAATCTI'rG
ACGAGCCTGT
GTGCG.CTGT
CGGCGCATTA
TTAAATATCA
TCGCTI'GATA
A'DTAAACTCT
TATGGCATGA
CTGATTGTCA
T.CACCAACCA
ATAACATTCT
AGGTITGGC
AAGTGTAITT
TGCGCAAAAA
CCAATI'CA
TCACCGCTT
rITIAACCGA
ACATI'CAAAA
TCACTGTGGC
ATTIAAAT
TGGCGATC
GGATGAAAAT
TTTCACGAT
TAGCCCTAAA
TGAAAAAGGG
CATCA71iTIc
AGAATTTAAT
ATTAAGGAGC
ITrTAGCTCT
CCTGTTCGCT
GACTATGGCG
CATGCCGGAG
TACGATTTTG
GAGACITTTCC
TATTACGGGA
AAAT GAAG:
GTGGAATGTT
AAAGAAACI'
GTGGCTTTAA
AATAAAGTGG.
TTGGTGGAGT
TCTCAAGTCA
ATGATGCCCC
TrAGAATGGC
CCGGTGATII'
ACATGGAAAT
C'rITAGA.AAT ACGGG~rTGA
TGGAATGGAT
CTACCCATGA
GGGATTCCTTI
ATAGCGATAC
CTACAACGGT
ATGTGGAGCA
CCACATTGAT
AATACGGGTA
A'TTTCAAAAA
GGCGACcTT cTrI'GATrCT
TAI'CTAACT
CAACAAACAA
TGATATM~A
TTTTGACAAA.
TAAAAATAAT
CAATCTCAAC
AAATAAAATC
TGGCACGATT
TCTrT1'GCG GAAGGGTI GG INFORMATION FOR SEQ ID NO:117B: SEQUENCE CHARACTERISTICS: LENGTH: 732 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPEt DNA (genoruic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-.feature LOCATION .732 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1178
CCTITTCATGG
TCCTTGGCTA
ACGGTGATG
GGCTTAGCOA
CAAAAGCCTT
T
rrAGGGGGGG
AAAGAAAAAC
?I!AGACATI'G
GAAGTCATOQ
GTTGGCGATT
GTI'GTGGGCG
TATGCGGGTA
AATTTTATC
CGCTCACGCT
TTTATAAACT
.TGATCACTCG
TATTCGCTAT
CGTrrI'rTG
GCCAAGAAAA
TrrriTTCTT
CGCTTGCTAT
TTATTGAAAA
TGTrI'rrGTT
TTGGT'I'ITGC
CTCACTCTITA
TTTAGAGATC
CCCCAAACAC
TATAGGGCTT
AGCGGGCATG
?TTAAGGCG
AGCGTTTGGC
GGACTCCGTG
TATITTATCT
GCATTIATCGC
TI'TAGAAGGC
CTTIGCTCATA
GACGCTC?1'T
GTTCTAGGGA
CAGCAAAATA
TrAGGGAGCT AGCI 'rCAT
TTAGTGGAAT
TTTTTCATCA
ATCACGGCTA
GTAATCGTGA
GTCAAAACTI'
TTGCATI'IAC
CTACACCGCA
TTGATAATAT
AGGTCATGAT
TGTI'TTTCAT
GCGTATGT
TAAAAGAGCA
CTTTAATAGA
TTGGGATCGC
TGATGT'I'1'T
TAGCCT'I'IGT
ACATCAATAA
TGGCATAGTC
CAT1T1TATC T1'TAGGCTI'G
CAGCCATTTC~
GGTGCTGCTT
GATCTATCCT
AATCATGTr TAAACACTrA FrrCCAAAATC GTIT1TIGCTC
AAACTATVITO
AGAAAAGAAA
120 180 240 300 360 420 480 540 600 660 720 732 GAATGCTTGA ATATTI'CAT ATGAAAAAAA GT INFORMATION FOR SEQ ID 140:1179: SEQUENCE CHARACTERISTICS: LENGTH: 487 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO j, 1 9 6/09122 9 /IfY~ (iv) AN'TI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .487 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1179
GTI'ATGGCT
GCGCAAACAA
AATGAGCATIG
GGCGAATGAA
TTCTATTTGC
CTTTATTA
CGTGAATTAC
TACITTI'A
CGCCAT
7TGGGCTrG
GGGCGTII'CA
ATTTAGGCC
TCTTGGGGGC
GTCTATGCCT4
GCGAGCAGCA
TACC'TI'CTG
TACTTTrGG
TGTTTGTGC
ATTI'AGACAA
TGTrCATGCT
GCTATTGGGG
TGATCTTGCA
GCGTGCTAGG
GCTGCACAG
TAGCGATACC
TAGGGATA
AACCAT1TCI
CACAGCCGGG
GTGGACCCT
TTTGCGITrTr
GTTTTATTCG
CTATGCCGCA
ITI'CGCTCTC
AGTTrGGTrT
TCCATTAGCG
AAAGAAACTT
TrAGGCTCTC G ?I'TAATGA
GGTGATCCT'
GTATCTTGGC
TGTAITZ'
CTATCAATCA
GTCYGGGTGTG
GGGCGI'GAT
AAAATTGGCC
CTTATITI'G
TGCCGATCCC
GTATFI'CAAA
INFORMATION FOR SEQ ID NO:l180: SEQUENCE CHARACTERISTICS: LENGTH: 486 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION I1.. .486 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1180
CGATATTCCG
GGCGAGCATQ
ACTCAAAAGT
GATGTGAG=I
AAAAGCGTGC
AGCAATCAAA
GATTTGCAG
AACATCGCTA
AAAACT
ATCAGACGAA TCTATI!AGCC GTAGAGGCTr TGCGGTGGTG CTTAGCCGA AATCAATITCC CGCAAATGAA TCTCAATTCG AAGAAACTTA CGAAAAAATG GCATGGACGA TTACGCTAAA AAGTGGAAAA AGTGGCTTCT CGCATGTGAG TCGAACGACC
CTAAATGCTG
GC T3ATGAAG
ACTATCATGG
CAAAA.AATGG
AGTTCTAATT
TCCGGACACC
AAGACTTITGG
ATGAATI'TAG
CTATTGAAGC
TTAGGAATTT'
TGATTGTCCA
AGCGCTTGAG
TAAGCTCAGT
AAATTGAAGC
CTGAITCTTC
CGCAAGGGCC
AGCTGGGCGC
AGAAATCAAT
Cr.ATATGAGT
CGTI'TTAGAC
TATGGTAAGC
AGATATTTA
AcAAAcAAGT GAATITTI'I! INFORMATION FOR SEQ ID 140:1181: SEQUENCE CHARACTERISTICS: LENGTH: 183 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular S (ii) MOLECULE TYPE: DNA (genomic) A 8t I V% l F% Iu f r-
POUS
IPEA/US
9610912.2 16L)Lt, ,990 (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 183 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1181 ArTGTTI'AA AACTTAATCA GGGGGGAGTT TATCAAAAAA GGGT GGATT GTTAAAGGT'r TCTGTGATCA CGGCGTGTTT TAATAGCGAA AAAACCATIG AAGACAC CAT TCTTTCCGTG CTTAATCAAA CTITATAAAAA CATTGAATAC ATCATI'ATAG ATGGOOCTAG CGCGATAGCA INFORMATION FOR SEQ ID NO:1182: SEQUENCE CHARACTERISTICS: LENGTH: 1992 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1992 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1182
AATCATATTG
AACAGCAGGG
CATTTCAAGQ
GTCAAAGAAA
TTCA1TT1AG
TTGAGATTGA
GGGAGTAACC
TArrrACAGGA
TTCAAGGAAA
TTCAGTAATG
GTGCTTTI'rA
GTGCCTAAAG
GAATACTTGG
CTAGGCAAAA
GACAAGGTCT
ATGGTGTTAG
TTGGAAGTCG
TCTAGCGACA
GCGATCAATA
CAAGACACCA
GCTGAACCCG
TTITGCAAGAA
TGCGTGGCGT
TGAAAGAGAT
TTrAAGGAAGT
TGCTCCCTGA
CCAATTCGCA
CGC
4 I'1'TACG
CTITAGTGCA
AAATGCCTAA
ACACGCAAGA
AAATCACTAA
GCGCGAATAA.
CCACTAATGA
ATCCCT'rTAG
CAGA.AGTAA.
ATGAGCAAGT
CCTI'AATCAT
TITCTAGCAC
TTAAATTGGT
AAAATATCTT
?I'AAAGTGGT
CAAGCCCTGA
AGCGTGGGAC
TGATrrGTGAT 2'ITAAAAGAA
GCAAAGTGTT
AGACACCAAA
TOTCGCTGGG
AGATAACGAT
AAAAGCGATG
CGGGGCGGAA
AGTGGTGGGG
AAACAGGAGC
AAGCTTGCAA
AGTGATCGGCT
CCATAAGGAG
AGACAATCI'
GGGATCGGTG
AGCGATCACT
CTTGTCTCAT
TGAAGCGCGA
GCAAACCCA.A
'TCAGAT-GTG
'TTTGAAAGAA
TCACATGCCA
CGTGGCGT1GA
AGCGCTCTGC
TT'GGAAAACA
AGAGAAATCA
GTGAGCATGT
ACGATCAAGT
AAAAATAAAG
GITTATGGCG
GTTCT'GATGA
GACAAATCCA
ATITTAGAAA
AATTTI'ITAG
AATTGGATGA
COTTITTG
CTTTTAATGC
TTCTTTAAAT
TCTAATGACG
AAAACCATGC
AAAGCGGGGA
TGAGAGACG
AGCATTCA
GCATTTTAGG
ATTCAATGCA
CTTATACGAG
AAATCCAGTI
TTrI'rAAAGA
TGATGGAAAA
AAATI'TCTAA
TGGATATTCT
mTTC1'ETC
TAATTGGCCT
TCACCGAAAT
ATGGCTCTAA,
CCGI'rGAAAC
TCGCTTTGAT
TGGTTG3CAGC
GAGCGATCGT
TATTGAACAA
AATTAGGGCG
AAGAAGACTG
ATTI'TGCGGT
CGCTAATGGA
AAATCTTITGA
GGTGTCCTTA
AGATAGT1G
CATGGGCATT
GTTAAAAAAC
CAGAGAGGAT
CCCGTCATTA
AAGCTTGCCT
TI'TACCACTA
CATTGACAGC
TAAAGGTAAA
TTATAAAAGC
AGCGACTTI'A
CT1'TAAAATG CATI%3AAAAA
GAGTGCTATC
GAGCAATCGT
TCAAGCCCAT
CATGCAAACA
GCAAGCCGTC
GCGCATCACG
TCATGCACTA
AAGcTATTCT 120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1140 1200 1260 1320 PCTUS 9 6/ 09122 HANS IS DEC 1996
GGCTTGGAT
GCTTTAGGGC
GCGAACGATA
CAACACAAAA
GGCGTGAGCT
GAAATCATI'A
GCCGCACGAG
CTCGCTGAAA
CAAAGCATT
AACGCTTCTA
TCTTAGAAA
AAAAAGCAGT
'PrAGAGGGCG
AAGAAATCCA
GCGCGAATT
GCCTGATGGA
CTCAAAGTGA
GAGATATGC
CCGGCGAGCA
GGACGCAAAA
CAGACACGAG
TTGAAGCCTT
TCAGTCAAGA
TTr
GATCCAAAAC
AAAAATGCTA
AAAAGAATGC
AAcTTCCAAA
AGCCATGAT
CGATCAAACG
TGGCAGAGGC
ATCCCTCAGT
CGAAAGCA T
AAGATCGGT
AATTGACAAA
GCTTCGGGTA
GAAACTI'CGT
GTGCAAAAT
ACGATAGAAA
GAACAAGGGA
AATCTATTAG
TTTGCGGTGG
GAGATTGAAG
AAAAACCAGG
ACTGAGGGCA
GTCTCTAACG
GGGTGGAATr CTAATIrTTGC
TAGAAAAGC
ATATCACCAC
AAGACATTAA
CCCTAAACGC
TGGCTGATGA
CCAATATTAA
TTAAAGAAGT
ATCTAAAAAT
ATATITTAGA
GGTTACTAAC
CAAAGATCTA
TTCAAACTCC
TI'CCAFTCAA
AAGCA'DTGTA
TGCTATAA
GGTG3AGGAAG
TATTCTCGTI'
AGAAGAGATC
CGCTAGCGAT
AGATGTGAAT
1380 1440 1500 1560 1620 1680 1740 1800 1860 1920 1980 1992 INFORMATION FOR SEQ ID NO:1183: SEQUENCE CHARACTERISTICS: LENGTH: 1275 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .1275 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:11S3 CGTGGTGAAT GCTATITTTGA AAGAGAAAT1T TCTAAGGTTC TATTATI'TAT TGGGGTGGT TI'AGAAGGGA GGAAGCAAGA GTCTTCIT AAGGAATTGA AGAATAAGGA ATI!AAAGAAT GAAACAAAAG CCAAGAGAAA ACCCAGAGCA ACTCCAA.AGA'TCACGCCTCC TAAAATCAAA G TC AAAACA ACGCGCCAAA ACCTGAAGAA AATAAGGAAA CAAGCCCTAG CTCTCAATITC ACCAACAACA CCC'1TCAAGA TAAGGTCGTA CCTATCACGC TGTATCAAAT CCAAGAAGAG GCTAGGGATC G'TTTGATCGC TGAACGCATT CATGTAGATQ ATGACAAGCT AAACCAAGAA GATI'TAGACC ATITCAAACA GATG2CTTATG CAACTTAAAG AGCATTTAGA AATGCAAGAA GATACCAGCT CTGAAACCAA AATGCGCGAA ATCCCCACAG AAATAGAAAC CGTGCGCTAC GCTATGGCAG ACCCTAATIT GGAAGTCCCA ATGAAAACCC TAAACCCTCA AATCGCCCAA ACGCCCGTTA TGAATGGGGG TGGGOCAG GGTAAAAATG AAGTGAGCI! CAGTCAGGCC GAATCTAAGG ATAAGATrT AGAAGAGCAT GTGATGATCA GAGAG
GGATT'GATOA
TATGCAGAGC
GATAAAAAAA
AAGGATI %3A
GAAGTCCATC
GGGAGTAGTA
AAAGATACAA
AATCCATTT
GGGGGCATTI"
CAAGAAAAAT
AAAAACCAAG
ATGGCGATGA
GCTGAGGGGC
rrrGTTGCGTA
TAVITIACAACA
ACTTCCACCA
GGGGTGAGTA
GTCTTTATI
TTCATCACCT
GGAAAATrI'r
CTGATTCTAA
TCCGCCAAGA
AAAATAAAGA
ATGGGGACGC
AGGGCGTTCA
CCCCTCAAGC
TGGTAATCC
CATTGCTTGT
CTAAAGTGAG
AAATTGAGCG
TGGCGCAACA
AI'ATAAACT
ATATTTGCT
AACACAAGGA
ATCAAGAGGA
AGGCCAATG3A
CGCATGAGCA
TTATATCAA
TTCTTATATT~
AGTGGAAGCC
ATTGAAGAGT
AGAAAAGAAA
CAAAAATCCC
AAATCAAGGC
TACTGAAAAA
TAATAACGCT
TAATGTTCG
TAAGGCTCAA
CTTAAAAATC
ACAAGGCATG
CTATAGAGAT
CACGAATGTG
GCAATTCAGT
TTrAGAAAGG
AAAAATAGAG
AGGCTCTTITC
GGAAAAAAGG
ATTAGTGGAA
GTCTAGGATI'
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1140 1200 1260 1275 AAGCAATTCA TCGCCCAAAA 'ITTGAAAAAT TGCGCGTrAA INFORMATION FOR SEQ ID NO:1184: I SEQUENCE
CHARACTERISTICS:
7-h LENGTH: 1008 base pairs PCT/US 9 6/ 09 IPEA/US 18 DE 12 a 1A96 852 JB) TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (geflomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .1008 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1184
AI'GTGCAAC
TTCAI'1ATCG
AACAAA.AAAT
?I'AGACGAGC
TCTAAAGCG
AAAGATGAAG
TATTI'GCAGA
GAAGCGT 1GT GAAACT~rGG
CTCTATTIAA
AAAGCGTCGT
C TITT1TGGC
GATATGAATA
TCTCAAGGGT
GCTCTA'I GC
AAACAAATCT
GATATGGT1GC
ACTTCAAITTT
CTCI'GTGAT
TTTTGCAAAA
T=AAAGCA
ATGTGGA.AAT
AA.AAAATCGC
AAACAAAAGA
TGAAGC T*17r
AATGTTTGGA
TGCATTTIAAT
TAGATTI'GAA
AAGAAATI'GA
TCCCTGCTTI'
TGCTTTTGGA
ATAGCCCTAT
T rCCTII'GA T1AAAATCTC
CCTCTATAAA
TTTATTAGAA
ATTCGCCCAA
TGCTAAAATT
GAGCATI'GAA
TG;TTTTAGAT
CACCGTGAAA
GCATGCGTAT
AGAAT1TAGAG
AGAGAATAAG
AAAAATCGCT
TACAACCGAA
TATTTTAGAA
TCACAAACCT
AAAAGCGAGT
AAGCCATAGG
TAAAA.AAACG
GA?1'CTI'TAT
CAGGCTAGAG
AATCAAAACG
TCCAGTGA
ATCTTAAAAG
T1'ATGCTA GAAATrrGC
GAATTAGA.AA
GTGCCTAAAA
GAAGATGCGG
CTGAATCACT
CGGCTAGAAA
AAACATGCCC
TGCCAAAT?1'
CTGACTITG
TGTCCTGTGT
CATGCTATGG
TTTCTATCGC
CGTATITCAC
CCTATGCOAG
TG?TIAGC
GGCTTT1AA
AAAATTATTT~
GCTrCCCC
AAGATTATITC
'rrGAAACGAT
CTAA.AATCTT
TAA.AATCGCA
ATGTGATCGA
TITTTOCAGGA
TTGAATTAGA
AATACCGCTG
GTTACCAGTT
GAGTGGAT
TrI'ATTCACT
CCGAAAGAGA
CAGCGAGAAT
TAGGGCGTAT
TCGCCCCTTA
TAGCGTGGG
AAGG-AATGTG
AAAGGCTI'TA
TAAAAATAC
GCATGTI'TCA
TGATGAAAAT
TCTI'ATOG
CATCGCGCGA
GGTITTACGC
CAAGCATI'GC
AGCG'ITTATIG
120 180 240 300 360 420 480 540 600, 660 720 780 840 900 960 1008 INFORMATION FOR SEQ ID NO:1185: SEQUENCE CHARACTERISTICS: LENGTH: 765 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (Iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc..feature LOCATION .765 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1185 ATTAGAGGCG CAAAAACGGG TCAA.AACGAC CACTTAAAGG GAAAAATGAT I CGCTCTCAAA ATAGCCCI'A TGTAACGCCT GACAACCCTI'
ATCTAACGCT
EA GTATT CTI'TAAAGA CAAGCGTTTA T'rGGAGCAAG
CCTTAACGCA
1AG TGCTI' TAAACAATGA GCGCTI'GGAA TTGGGCCG ATGCGGTGTI'
GAAAAACAAA
AGAAAAAGCT
TAAATCATGT
GGGCT ,GGTG 120 180 240 PCTUS 96/09122.
IPEA/US 1I8ODEC 1996 853
ATAGGGGAGC
AGGGc VrCTA
GATTATGC
CTGTCAAGCG
GTGCGTAAAA
TTGTTATGG
CCCACTTACC
CTATACAITC
CAGCAATGCG
TGCTATACCA
TTGTGAGCGC
GCG'TITCTI'C
CTITI'GAGGC
TCATACAAAA
ATTATAAMAC
AATTACTCCA
AAGATAAAAT
CTTATCAAGC
TAAATI'CTAT
GCATGGTITC
TT-CTGAAGAA
TTTAATGGCT
T'rTACTCAAT CGCTTTrGCAG,
AGAAAAAGGC
GTATIGCGACC
GCTTCAAAAA
CAATACGATG
ACTAAATTAG
A TTTCTAAGG
GGGGTGTATT
cGTGCTITACA
GAATI'GACCC
CCCGATCACC
GCTAAAGGCA
CTTAAGGAAG
AGGGCAAACT
CGAAAGCGAT
GGAGGGAAAA
TAGAACCAGG
AGCGTTTGGA
AAGCGCAGTI'
ATAAAGAATT
AGAGTAAAAA
TCAAA
CTCTAAATrA TGcTTrACAA
ACCCTCTATT
GI'AGCTAAG
TTI'GGAGCAT
TI'GCGTGATC
TGAAATGGCT
AGAAGCCGAA
300 360 420 480 540 600 660 720 765 INFORMATION4 FOR SEQ ID NO:1186: SEQUENCE CHARACTERISTICS: LENGTH: 429 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc..feattire LOCATION .429 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1186
GCGCATCAAT
AI'GGAATCG
AACAGGAATC
CTGGTGGTGG
ATCAAGCT'G
GAAGCTTATG
GGCCGGI'rAG
AAAAAGGGC
CATCTCGTGG
CTGCGCTITTT
AAGCCTCTAG
GCAAACCCAA
TAGATTTrAA
AAAATTAGA
ACTCTTTGAG
TGTTAGCATG
AAACGGCGI'
GGATI'TGAGC
CGAAAG3CTAT
GGGCGAAATC
GCATTTGGGT
CGCTTG3TAGG ATITI'AGCAT GCGATGTGGG ATCTTGCCTr TOGAAGCGAT GATATI'GA GAAAAAAAGA GCAGATACCC ACGCCCGCAT GTTTTTATCA ATCAAGATAA AAGAAAAATA AGCGGATCGC AT1'ITAGAGC GCTATI!GCCA
GI'AAAACGC
'TrTACGCCAC CA'1'ICAAGTG
TGAGCATTIT
TrCTAGCGTA
TACCAAAGAT
GCAGGTTTA
120 180 240 300 360 420 429 INFORMATION FOR SEQ ID NO:l187: SEQUENCE CHARACTERISTICS: LENGTH: 1731 base pairs TYPE: nucleic acid sTRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genoiic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc-feature LOCATION .1731 POUS 96/0912.2 i f J MS i 8D E U -jo0 854 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1187
AAGAATGAAA
GTTGXITI'
TTGATCACCG
CAAGGGGGTT
CAACACCTCC
CCTAAAGATA
AGTAAAGTG
AACATCAAAC
CCCATCTA
GAAGTCCCTC
ACTCAAATTT
AACGTGAAAA
TCCAAAGAAT
AATAAGATCG
GTCAATGCGG
AAT3TCGTAA
GTTGGCGGTG
AAAGAGCCAG
AT1'ATCGAGA
GATGGCAAGT
AGCGATGAAT
AATAGAGGCG
CACAACGCCA
ACGCCI'TAA
ATCGTGCCTI'
TCCATGTTTG
AAAAAAGTAG
GAATATTT
CTCTI'TAAAC
ATTATCAA
TCATCAAGCT
CTITACTCGT
ATGGGGTTTT
AGCAAAACCA
AAGTGTATGA
GCTITGAAAT
TCATTCGCGC
AAGCCAATGT
CTAGCGCT'C
TAGGGATTAA
TCGTGAATGA
TAGCCTI'AGA
TCAATATCTI'
AGTTGATTTVI
GGAGCGAGCA
TGCCGGGAGT
AAAAATACGA
TCAAGGGCGA
ATAAAATCGC
CGCTTAAAAA
ATGATGTGGC
CTTGAGCGA
TCAAGTATAT
TCAGCGAACG
AAGAAATGGA
AAGATCAATT
TAGAAAAGAT
TCTAATCAA
GGT ITTrAATA TrGGATrI'AA CAATAAAAAG CAAAAAATCG GTlTAITG CTCTATCCVIT ATTTGAAAGA TrGGATTCTA AATCCCI'AT AAAGTCI'AA AGAAAGGATC ACTCTCGCTr CTrTGACACT AAAGACTIG CATTGAGGGG GAATI GTCGC GCATAT T3CA ATCCCTAAAG AGTGATGCTC AAGCTTAAGC AAATTTAATC GCTGCGCTG AAATGGCGAA TCAATAGGCG GCAATI1GCGC TACAAACAAA AGCCCCTATI GTGGGGGGTA CAGCCAAAAG AAAAGCACCA AAATTTAGAA GAAAAAAAAG TGTGAGCAAT ATrGGGCCTG AAAGTCTCAA AACACGACCA GTrGGCACC TIAATGCGTr GCTCGAAOAC GGGGCAAACG AATCAACGCC CTAGTCAAAC GGTGAGTAAT TTrGAGTII'A AAAAATCATG CATAAAACTC TrTT(GTGTrI' ATAGTGTI!AT CATGCTGGAA GTGGTGCCTG CGAAGAAGAA GATGAGTTGA
AGGCTTAAT-GCAAGCTI'TA
TAGAGGAACC CTTAAAGAGC AGATGAAATC TCTTCAGACA AGGTA 1TATT
CCCTGATCGC
TTAAAGAAAA
GCGATAACC
AAGACGACAC
CTCAAGGGAT
GGGCGACT1GA
GCACGATI'GA
ACAGCGTGTr
CTGACATGAA
TGCCTAAACT
AGGGCGATAT
ATTTTG'AAAA
AAAACAAGGT
AAGAGACTI'D
AAGGCGCTCC
TGCAAGGATr
ATTATGAAGT
TGAATGCQGC
CTTTAGAATA
AAGCCAI'IGG
ACCCTATGGC
AAAAAATCTT
TCATI 'rCTA
ATGAAGATAA
ACAAACTCGG
GCGAAGAAGA
GTCCTGATGA
GCGCGAAAGG
GCAACGGATIT
AGCGGGGGTr
AGACTACGCG
C?!A.ATCITA
CATTCTTGTC
CCCTAAAACG
'I'ITATCAA
AAGT'rTAAAC
TGTGGCTAAA
GCrI'TCACCC
CACGATAGAA
ACTAGAAAAC
CATTTrAGAA
GGTCGCAAGG
TGATCCCAAT
TAAAAAACAA
GAAGGACAAT
GGGTAAAACC
GGTTGTGGTG
CGAGCCTTTA
TGATAATCAA
GCCTATGATIT
AGGCTCATTTI
TAA.AAAAGTG
GGAAGTGAkA
CGATTIAGG
AGTAAGATkDT
AATCGCCACG
T
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1140 1200 1260 1320 1380 1440 1500 1560 1620 1680 1731 INFORMATION FOR SEQ ID NO:11SS: SEQUENCE CHARACTERISTICS: LENGTH: 597 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .597 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:118S
AAATGGTGCG
CGCCTTACCA
AACCATAAAG
GATTCATGT
GACGCGGTGA
,GCCCAGAAAT
G1-rATrGTGA
AAAACCATCA
TGATCCAAGA
?I'ATTAAAGG
T1'ATCCCCCA
ACCAAAAACC
TTTTAGAAAA
TAAAAGATI'A
CGAAAAACCC
GCGGAGGAGC
TGCTTITCGCT
AATCGCGCAA
TTTTTTTTTA
AGCGGATA
CTTGTTIGI'
AGGGCAGGCT
CCATI'TAAAA
TAGCTAT 3AA GTrAGGCGTG
TGCAGTTTGG
AACGGTTTGA.
GTTAGAAATT
AAAAGCGGCT
TTACCCCAAC
CAAGGGATAT
GAAATGCCTG
GAAGCGTATC
GATAITATCG
ATTTTATCTA
?I'TTAAGCGA
GTCTGGTr.AT
CTATGAGTAG
GCCTGAATGA
TrAATATITCA
AAATGAAAGA
TCAAATITrGG
CTCAAGAAAA
TCCCACGAAC
ACATGAAAAG
CGCTTTAACC
TGTGAGATTA
GAGCGACGGC
AAATT'TTATA
TGAATTTTTA
GGATAAGCTT
PO/US. 9 6 TTAGAATACG AGCTGTGCGG T~aAGATI'AAG CGCATCAATC ATCTCGTGGT
GTTAGCA
09122 Ujc u i.Thz;o 597 INFORMATION FOR SEQ ID NO:l189: (j)-SEQUENCE
CHARACTERISTICS:
LENGTH: 828 base pairs TYPE: nucleic acid STRANDEDNESS: double' TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION .828 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1189
AGGTTAAAAA
ATGAGTGAAA
TTAAGGCAI'
GGCACGGACA
AACCAATACA
GGGAGCGAAG
AACTTCGCTT
CACCCTCAAA
T'TGAGCTAT'
GAAATATCGC
CTCACTAGCT
TTGGGCCAAA
GCCGGCGCGA
TGGCAACCAA
AAATCGCCAT
TAGACATTGA
AGCAAATCGG
TCAATACCGG
AAGCCAGGAA
ATTTAGGCAA
CCATCGCCTT
TCCCTGATGA
CCCAAGTGGT
ATAAAATTGA
AGAGTGCCAA
TTAAAGAAAT
GCTIACCCCC
TTrACTCATT
CTCTATTACA
CGCGGCGGTT
CGGTTTAGAA
AGTGATGGAC
AATCAAGCCC
GA'TITGGCC
AATGAAAGCC
TAAAAGGGTT
AGTGGGCGGC
AACCACGCTC
GATGTI'CACT
AAACAAAAGG
CAAGTGGGCG
GAGATTTCTA
TTAGAGGAAT
TACGCTAGGG
AAACTCACTA
CAACAACTCG
CACATGGAAG
GAGATITCCA
TCCACGGTGT
TTGAGAGCGG
GCTCGCATI'G
?1'rGAAGATA
TTAAAAAAGA
CTCAATTAGA
AAGACACCAC
AGCAAATCGT
TTrGCGAT
AGCTTTTAAC
AAAGCTTGCA
CTGATTTCAT
CCCCTAATGC
TTAGAATGGC
TAGAAAACAA
TGGCTGAAAT
AAAGCGTGGA
TAGCCAAACT
CTGGTCTT
CGAACTrC
AGGCGAGATI'
GCAATThAAC CTTI'CAGTCt
CAGGACTTTA
AACGCAAAAA
CATTAACGAA
GGcTGAAACT
GAATTTAGGC
ACTAGAATCG
CITTAICCGC
TAACAAACTC
AGACAATTTT
120 IS0 240 300 360 420 480 540 600 660 720 780 828 CTATCATGA GAGATI'TTAA AAGTGGGGGA INFORMATION FOR SEQ ID NO:1190: SEQUENCE
CHARACTERISTICS:
LENGTH: 582 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature, LOCATION .582 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:119O PoT/us 9 1 PENUS i /0912a2 DU"E C I 53,6
AGAAGTTTGG
AATTIrTrTA
GTGATAGTIGG
rIGGTrATTT
TCTAGCTCTT
AGTGCGCGCA
CAAATCAGAG
CTCTCTAACA
GATTCTAATG
AAAAAACAAG
GAAAAGGGCG
GCGAAAAGAA
CGTG~GCT=T
TAGTGGATAT
TTIATI'rGGCT
AATGCTACCA
AGAATTTAAA
TCGCTGAAGA
ATGOAAAACCA
AGGAACTGAA
ACCAATGAAC
TGAGCGCTG
TAGGTITAAA
T1'GGGTCGTAT
TTTAATCGCT
ATTCAGCCAA
AA.ACCGCTCC
AATCA'II'CA
CAAAGACAAG
AGCTAGAAAG
AAGAAAAATA
CTGT*TAGCCC
AGCATTGCGT
AGCGATGTGC
TTACTAATCA
AAAATGTTTG
AATCGCAAAG
AAAAAACAAG
CTTCTAACA
GATAAGGGGG
GCGTAATITC
ACAGGCACAC
1-1CTAITII GCCAG 1711I
AGTGGGGCGT
CGTTAATCCA
ATGCTAAAAA
AAGAGTCCCA
TI'ACCGAAGA
AT
TGGTTTGATG
GAGGGGGITI'
AATCACTCTG
AITGGACACT
GA'rrGTrATA
AAGAAAAAGG
T~TrGAAAAA
CCACAAAGAA
AATGA'ITCTC
INFORMATION FOR SEQ ID NO:119l: SEQUENCE CHARACTERISTICS: LENGTH: 1617 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .1617 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1191
CTTATGGATA
GGGATCAT
TTGAAGATTG
GAAGTGTTG
rTTGAACA
GTGATAGAAA
GTAACCGATG
GTGGAAGTGG
CAGCTGAAAC
TATATCCGTO
CGGCGTCTI'Q
GAATAAAA
ACAGACACTA
CCCATI'GCCA
TTAGTAGAAA
TTAAGCTIAA
CTGGATACGC
?TAGAGGGCG
AAAATTTGCG
GGCATGCAAT
TCTACGGAAT
GATCAAAACC
?I'AGGCGAAT
CCTAACATCA
TGGGAAAATA
GAATTAGAAG
TTGCAAAGCC
GAGCCAAATT
CTTCTI'CAAT
ATCCTrATAT ?1!ACTAGCGA
GGAATTTAAC
ATGAAAGGAA
AAATCAA6AAG
OTGGAACCGT
T3GAATTACG
CCACTAGCGA
GCGTAACCCC
ACAAAATCGC
AAAGCATI'rA
GACGCTTTAA
AAATCATCGC
AAGAATCTTA
AAGTCAATAT
TTGATGCGAT
CCATCAAAG
TAGCGATCGT
TTAACCAACG
ACCAAAAACA
ACGAATGCGA
AAGAAAGACA
AAGGCTTGAA
ATCACCCGTTI
CTAACCCTAT
TATATTCGTr
CGCTACGCI'D
CAATATI'GAT
T3GCGCTGAA
GAGGTTGAAT
AGGGGAATAT
GCGCATTAAA
GGGCGATAT1G
GAATAAAGCA
ACTAAGAAGC
TCAAATCAr
TTTGAGTTGC
CGCATGCCCT
TTTGAATAAG,
TCCTAAACAC
TAAATCCTTIG
TOAATGGCTG
TT1TAGTGCCG
GGCTAGGTTA
TGA.ATITTTGT
CTGCGAATAC
GGTGCGCACC
AATCATGCCT
CCGCCATCGT
AGTGGTGGGC
CTTI'GTGGGG
TATTTTGGAT
ACAGGGGGCG
TTGCAGCATr
CCAGGCACCA
ACGGATTTAG
AATTTCACTA
TTAGGCAAAA
AGTGCGGCTA
GAGGGCATGT
CTCATCAATA
AGACCCACGC
?I'GGCGCGAT
GATGTGGAAC
ATTCTT1TCT
TTGCACCCTA
AAGGTCAAAA
ATTAAGCCC
GATAGCGAGA
GGGGGCTG
GAAAAACTCC
CGCAATGTT
CCTGTGGTGT
TATAKL'TCGC
AATAGCTTGC
TATGAAATCA
ITTGGGGCGA.
GTGCAATCC
TTCATTAAGA
TGTTAAGCTC
GCAATI'ACCA
T'GAGCCCT1TT
ACATCGGGCA
CCGGGCAGAT
CCA'rrCAAAT
AGGGGTITGGA
TTTATGTGGA
TGCATGTAAC
AACACTCCGT
CGCCTAAGCC
AAGACAGCGT
TGCAAGAAGG
AAATGGCGGC
TTGGT=TI'GT
TAATCCATGC
ATITTTAATGA
GAGAAAGGGG
CCTT'IAGG
TAGGCTTGAA
A?1' GATTGA CTrAGGAGG
TAGAAAAAGC
ACCCCAAATA
ATCATTTGAT
ACCCGGAMTT
GCGCTCTTCA
TCTAGGGAAA
~GTTTCTAT'
PAGAGCATGGG
TTATGAACGC
TTTTCAAGC
CGTCCCCCAT
TITTAATC
ACCGATCCGC
CTTGATIGCCC
CCAGGAATTA
TTTGGATAAA
GA'I GTAGCC
CATTI'AACC
TrGGAACACT
GGGCAAGTAT
GGGGGCGCAT
AAAGACTGAT
GATTGAGGGC
GATTGTIG
AGGGGCTAAC
AGATTATG
CACCATGCGA
CTATAAAAAG
C"CGCCAAGAG
TGAAGCGAT'
CACCTCCAGG
TAAATCC
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1140 1200 1260 1320 1380 1440 1500 1560 1617 )INFORMATION FOR SEQ ID NO:1192: Pci-us
IPENIUS
96/091?T SEQUENCE CHARACTERISTICS: LENGTH: 1107 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1 1107 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1192
ATATGGCGTG
ACGAAGGCTA
AGCGCGTATr
AACTCATGGA
CAAAAAACAG
CAGCATAAAG
CAAATCGCTG
GCGAATGAGT
GGGAATGTTr
TI'TGATGAGA
?1'CCATCCCT
CAAAGCGATG
GCGTTATTGA
TATATTGAT
GCTCAAAGCG
TITAAAGACA
GATGGTAAAG
ATI'ATCCAAG
IGATGAAT
GATGTGGAAG
AI'ACGAA.AA
TI'CCGGACAT
AAGAATI'GTC
AAGCTTTAAC
COAGCGAAGA
AGATCAACAA
TAAGGGATAA
TTAAAAGCAG
GCTATAACCT
TAGTGG'?TAA
ATI'TAAGCT
ATGTGTATAA
TG?1'GGATTC
CGAGCCATCA
CGAATI'ACAA
AAATCGCCAG
TCATI'AACGC
TATTTCACAG
CCATGACAGG
CACTTA2I'AC
TGATGAAGCG
TAAAAACGCC
GCACAACATT
ATAAAAAGC
ACGCATTAAA
GCGACATGAA
CATTAAAACC
TAATATCGGG
AGAATCCGAA
CACTAATATT
TGACGGCTCT
'TTITGCTAGG
TATI!GAGGGC
TATCAAAAAC
GAAAACCAT1'
TAACACCGAT
CGAGCTI'
GTG3CATGATG AGITI'GTTT GATACAGAGT 'ITTCGCATTT AGCCTT'rA CGGATI'TGCA AAAGACTCCG CTCAAAAACA AAAGACACCA GAGAGAGGTT GTCATTAAAG AAGTCAATAG GAAGTGGAAA ACAACAAGAG TTAGAGTTTC ATTI'GCGAGA CATI'CGCTCA CAGATAAAGA
TGCTCGI'AC
AAAAGAAGCG
AGATTA'TIT
GGCTCTCGCT
AACGACCTTA
CCTWGTGTCT
T1'TAAAGCAT
GCTITTTAGGG
CTCAGCGGAC
TGGCTCTATT
GGTITTATD
GAAAGTGGGG
GTI'GCAAGAT
TGCGATITAC
CGATGAAGCC
TTACAACACC
CATGAACGAC
CGAAAACGAT
CATGGGTTCA
AATAAAGGGG
ACCaACAAGC AACGGGACTr
GGCTI'GATAG
GAGCCTGTGG
GGCTCGTTTG
GCTATCACGC
GACAATCAAG
ATATCATA
GITTGAACCA
TCAATCAAGG
TAAAGGGCAA
AATCCACGAA
AGTI'TAATAG
ATTTAATCGC
CCATTACAAC
ACAACAACAC
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1107 INFORMATION FOR SEQ ID NO:1193: SEQUENCE CHARACTERISTICS: LENGTH: 813 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURF- NiAJE/KEY: misc-feature LOCATION .813 -7 Z (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1193 I I V. vl e 1-3 Irr PUS 9~ 1 PEAUS I /0 9v
AAAACAAAGC
CGCGCGTTTG
GGAGAATCGG
AGTAGCGGCT
TTAAAACCAC
TTAAACGTGT
GTGTTACGCT
GGGCAAGCCC
TTAGATGAGC
CTTGATITTTA
ATAACCAAAC
GAAAATCGGC
TGCCATI'ATG
TTTAAGCTG
TCG'TI"I'IAT
kITrGAATAT
GAGCGGGTAA
ATAT1'GAAGC
AACAGCGAAA
ATCAAAACAT
TAATGCGTr
AACGAGTCGC
CTTTAAACGC
TCAAGCGTGA
TCGCGCGAAC
TITI-CAAA
AGGTCATTCC
ArI'TCATTCA
GATAAAAGCG
AGACTTAGAA
AAGCACGATC
CAATCATTCA
AATCGGCTTr
CGCCTTGCT
AGAAAACCTA
TTTAGCAAGA
CCTAGATAAC
AAATITAAGC
T1WTCCTCTTT
CCGCTTAATG
TCAAACGATC
AAACAAAAAA
CGGI-rAAAA
ATI'AAAGAAG
TTACGCATT
GTATIGG IAG
GTGTITCAAG
CACCCTAAAG
AGCCAGCAAA
GCTI TAATCG
GCCITAAAAA
GTGTTATTGG
TTAAACAATG
GTAAAACCTC
AGTTTIGCCCA
TTT
AACGCCTT
cAGAAGTTGT
TAGCAGGGCT
ACACTCAAAA
ATI'ACGCCCT
ATAAAAATAA
AAArrCCCAA
CAGCCA.AAAA
ACGAGGT'GCA
TAAGTCATGA
GCGI'ATTGA
TCTq GAAGA
AAGATTGTCT
AGGATCTAGG
CGCTTTATTA
TGAAGCGGTG
AAAGATTI
ATTCCCTCAT
AATCCACGAA
ACTCTCTGGC
TCTATT'GCT
ACAAGGTr 'G
TCCAAACGAA
TCCTAATCAA
TGAAAATTAT
GAACCCAACT
INFORMATION FOR SEQ ID NO:1194: SEQUENCE CHARACTERISTICS: LENGTH: 213 bast pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genemic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc-.featuro LOCATION .213 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1194 GGCTI'ATCCG CTACTATTCT TGGTATGTGG ATTATGTCT1' CATICGCTCT TCTTCATCAA ATCAAACCCT GGCCAACTCT ATCIWITTCA TAAATAGAAA GTTTGTITTA GCACAGTATA ATI'1TACTCA. ATAGGGTGTT TGGTGTTCGC GTT CACT1'TCTAG rTCATTCTTI' TAAA.AGGTrG GGGTrCAAAh ATCCTAGCGT TTCAATTTTT~ INFORMATION FOR SEQ ID NO:1195: SEQUENCE CHARACTERISTICS: LENGTH: 225 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: 7IN ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc-feature PCTUS 96/O912.i JPANUS ibuc.[uIjo96 859 LOCATION .225 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1195 A'rTCAGCGCT CGCACCAGCT CTTTAATTI'G CAAGAAAAAA CACCAAAAAA ATATCTrAAA TATTGCTCAA AATGACATCC GTGGTCTT'I CTATGrI'AGC AACCCCTTPI' ATTrI'AAA.AT TTTArFI'C ACCAAAAGAG CCAAGAAAAC GAGCCGGCTA AAGGGATrCT TGG7ITTIA ACCAGCTCCT TATTCTCATG; ACCTAGAATC TATCGCTCAA
AAAAA
INFORMATION FOR SEQ ID NO:1196: SEQUENCE CHARACTERISTICS: LENGTH: 351 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc..feature LOCATION 1I .351 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1196
GGCTTGATGC
GCGCTCGCT
GTCGCTATAG
CAAGACCCAG
ATGATCTTAC
CGAGAGAGCA
GCATrATCAT
CTTTGATGGG
GGATTTTTGT
AAAAACGAGA
AAGACAAGCA
GGCAAAAACA
AAGGrrAC?1'
GGGGCTGG
GTITGATCTTG
AGAATACATA
AAAAGAAGAG
AGACCTTAAA
TCATITAAAA
TATGCTTrCA TrTGTml-rT
GAACGGCTTA
CAAATGCGCC
GAACAAATGA
TGAACGCTTI'
ATGGCGAAGG
TTATCCGCCC
AAAAAAACCA,
TCTATCAAGC
AAAAATACTC
TTrAAAACTC
CTCTGAGATT
TGAGAGGAAA
CAAAAAAGAG
A
INFORMATION FOR SEQ ID NO:1197: SEQUENCE CHARACTERISTICS- LENGTH: 327 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc..feature LOCATION I1.. .327 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1197 AGGAAAAAAA TGGAAATCAT TrATTIATT GTTGCGGCGO TTOTGT TATTTAC A 0~ S? 5MBSIA101C. 9U I AACACCCTCA .AAGAATATTI GACTTGAAAA ATGACCCCTA ACCCAAATAG GCGCGTATAT CATAACGCTT TAAGAACGCT CAAAA AG GCCAAAGAGC GAAAAACCCC CTAAACCCTA 'ITrrGCTGGTG CAATCTAGCC GCGTCTTIA AAA TFITAG IrI'rATCCAT GAATI'GGAGC
TCTCAA
AAACCAA.AAC
CCCTAGACAA
ACA ITCAAAA
AGCCCTTAAA
CGAkAGAATAC
ATTCAAGCAA
AAACGCCTTG
CAGCGAACAG
INFORMATION FOR SEQ ID NO:1198: SEQUENCE CHARACTERISTICS: LENGTH: 1629 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .1629 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1198 ATGCCTA.ATA ACGCTTATT AAAGTCATTIr GCAAGGATGC CAATGCTTTI' TGTATAAATI' CCCAACAAAA CGATACGAGA CTTACCTTAA GCGATAAAAA T =GAALAAC ATITITACCA ATTTCTAGCA ATA.ATGCCGA TTATTTGAAA GCGTCTCACA TCT'ATTAG ACAAACTCAA CAACAAGGCT ATGACTTTr AACAGCGGAG GGACATACGC AAGC7TITTAG TGAATAAACC GGAACGCTI'r TAATG.GCATr CAAGACATI'T CGCAAAAATC ACCCACTCTT TAAGACACGC GACCACAA&G GGAAAT1GA AACGAGCATO CCGAGAITC CCTAAAAACO ATAAAAGCAA ATGCTCAGTC CAAAAGGTAA AGCGGGGTAA ATAATAAGAA ATIWGATGC CCAGTCAGGT CAAAAAACGC CAAGCGCA TACACCGAAA ACAAAAACAA GAAACTTTCC AAAATAAAGC ATI'ACAGAAA AAAATTA'rTC GAGACAPLTCA GCCAAGCGGA AGCCTTTTG ATGAAAGCCA
AGGTTTGAG
GCAAATCAAA
TGGTTTAGCG
CTI'ATGCGAT
CTACAAAGAC
ACTCCCCAAA
TAACGA'rrrA
GCTTTI'AAC
ATACATTAAT
AAATTTTAAT
CGCCCCCATT
CGAATACTAC
CACTCAAAGC
AGCCCACCAA
CTrAAGAATG
CATTGAGGGA
TTTCATCGTG
GCAAAACAAA
AATGCCCATI'
GGGAGCTATA
TGTCCGGCAT
VIWTTWGCCAAC
GGAAGTGATC
AAAAACGCGC
CCCAAAATCG
TCTAAACCCC
GTTTGAAAAC
AAATTTGCAA
CAAGACACCC
GGCGACGOCA
AAGTTI'GAAT
TTTAACGAGG
CTCGCT'ATG
CACCTAAAGC
ACCAAAAGCA
GAAGGGTCTA
T~
T
CAAACAAG
TTTAATACT
ACCCCTI'TAA
GTCAAAATCT
ATAGGCACCG
CTCAAACTCA
AACACTL'TGA
AGTAACCCCC
AACGATI'1"I'
TACACGCTCT
ATCGTGCCAA
TAGTG3GATG
ACCGGCACTA
TTOAT'ACG
TTAAGACCAA
GATITTTG
GGGCAGTA'T
TTGATIGCAAC
CAAGAGA?1'T
TAAGTCTCAT
ACGGATACAA
TCTTTGA
AAGAAAAAGA
ATGAGCTTTr
TAGATGCTAT
CGGATGAAAC
AAAGGGCTAA
C?TTI'1'AAA
TACTCAAAGA
GCATCGCTAG
ATGATCCAAG
ATTCTTGCAC
ACCTGATrI~
CTAACCCCTA
CTTTCAAATT
TCTTAGGCGT
TI'3TCCAGCA
CCGGATTCAT
AAAGGCTCGT
ACGTGAGCAT
CTI'CCAA6ACT
GCGATATGGA
CTCTGGTI'TC
TCACTATAGA
AATATTCAAG
TAGAAACTTTI
TGACGATTTA
GATCATCACG
ACAAAAATTC
ATATTTTT'lC AAkACTATCT'
TI'TCAATCGC
CACTATCGCC
TT~1'ACAAGA
'I'I'ACAAAAC
TTACAATAAT
CATCATTGCC
CGCTGGCACA
CCTI %TQCC AAACGACTrG
CCACTCCAAA
GGATTTI'rCC
GCCTAATATC
TTGCCTGAAC
TAGTCCTAAA
TrATGGGGTG CATCT'TlT
CGGCGAAGAA
Tl'rGATTTT'A Tr1'TGATGAA
AGACACGAGC
CGAACTAGCG
AAAAGGGGTT
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1140 1200 1260 1320 1380 1440 1500 1560 1620 1629 INFORMATION FOR SEQ ID NO:1199: Ci) SEQUENCE CHARACTERISTICS: LENGTH: 576 base pairs TYPE: nucleic acid P 1~ 9 6 /09122 I mqbUl 80 G A5,9 6 861.
STR.ANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .576 (xi) SEQUENCE DESCRIPTION: SEQ ID NO;l199
AAAGGGGAT
AGCGCAGAAG
CAAAATAACC
AATTI'GTCAG
ACTAAAGAAG
CTI'ATTCT
AAAAAATGCA
CTAAArrl'AG
AGCTTTGTTA
AAGCGAAGAA
TCATGAAAGA
AATTITrTAAA TTAAGAAT~r
AAAAGATCTC
CGAAGT TI'A TrGAAATTGA
AAGATCATGC
ATGAAGAAAA
TGGATGAACA
TAATTIAG
ACAAGAATGG
AACCTTACAA
AGACGCTGCA
TAGAGCGATG
TTCGCAATGC
ATrrAAGAAT TrI'TTATTTA
GATCGCTCTA
TTGTTTTCT
CCCTCTI'CCA
GATTTAAGCG
ACAGA.AGTGC
AAATTTGCCA
GCTTACGCTC
GAAATGGCI'
TTGGACGCCA
AACAATCTCA
GCCCTTTCGC
TTGAACATCT
CAACCC
CTTTATI'TGA
AAGAATTTGA
ACACTCTI'AA
AATrACT'Tr
GTGCAAATAT
AAAAACAGCT
TAGAAAAGAA
CTGTGGGAGT
CTI'TACATAG
AAATAAAGAA
GAACGCTTAT
ACATITACGAA
TGCCAAGAAC
CCAACAACAC
CGCTTTCATT
AAAGCACACC
GOGTGCGI'T
AATAAACTTT
INFORMATION FOR SEQ ID NO:1200: SEQUENCE CHARACTERISTICS:' LENGTH: 465 base pairs TYPE: nucleic acid STR.ANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) AN4TI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .465 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1200
GCCAAAGAGC
GAAATCGCCG
ATGCTATITAG
GTGGGGGCGT
CACTTCAAT
CAAACCCACA
TACCATAAAA
ATCGCCCTCG
TI'CTCAATGA
ACCACACGCA
CCTATGCTGA
TI'TGCAGAT
CAATAGAAAT
CCACCATGCPL
TGAATGACAA
CTTCCCAACT
GCCTGTGGAT
TGGAGAATAC
TGGGAITIVIG
AGACAATCAA
CCCTATGTCT
AGATTIAGAA
CAAACGCTAC
TTTAGAAAAT
AAAAAAGAAA.
ACCAAACGCC
GACAGCAAAG
GATT1rAACG
TI'AGAAGAAG
AAAAAGC7r
AGCGAACAAG
GA'TITAAAAG
AT1'1TGAATC
TGAAATTAGT
AAAAAGAATT
AGCTTTATGA
CAAAAAATCT
TGGA=TAAG
ATTTTATCTC
ACTCA
CTTATGCCAA
GGAA'rrrCTT
GTTITITAGAT
CAATTTTIGAA
TITM~AAATC
CGCCCCCTAT
TTTGAAAAAA
INFORMATION FOR SEQ ID NO:l201: POUS 96/0912.2 IPENUS 16 ut6 zzo 862 SEQUENCE CHARACTERISTICS: LENGTH: 1215 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1. 1215 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1201 ATGCCC 1711
AAGCGTTTTA
CTCAATACGC
CACACGCCCA
ATGGCTAAA
CATTATTTAA
ATCTCAAACT
ACCATGATI'
cGcTTCcATT
'FITGCGCGTI'
AACCCTAATG
CTAGAAATCA
TATI'ACAAAC
AACACGCTTA
GCCCCCATT
GAAAATG;AAG
CATGGCG 1TA
TTAGAAAGAG
GCT71TGATT'
AAGCCCTTI'G
TAAAAGCCCT
GGGATAATT
CTTTTAAAAA
CGAACGCTTT
ACCCCTTIGAA
AATCTCAAAA
TT1TAGATAA ATGGCGrliI' CGC'TrATrl
ATGAAGXITTT
AATTGAAAAT
TGCCCTATAA
AAGCCTTAAG
AAAACTTACC
GCGTGGTGG
AAAAATTCAT
AAGTGGA.IVIT
CCCCCCTAGA
TACCCAAAGA
AGTATAGAAT
AGCATCTITT
AGITTTTTC
TTACCAATTIG
AAGCTACCCT
TAATCCCAGA
CAACCACAAA
TCATCAALACG
AGACGGCI'G
GTTTGAAGAA
GATITAAAAAA
GGArTTTr TG AAGCGCI'Tr GGGTTrGGG
CCTATGCCAA
TAATGGGCCA
CATTTTCA
TCAAATAGAA
AGACACCCCC
AGCGTtATG
ACGCAGCGCC
GATGCGCCCT
AAATCTI'ATC
CTI TGAAA
AAACATCAAA
TGGTCATTAG
CTCCCCCTAA
CCTTGCTCTT
TTTGGCTA
AATTTAGACT
GGGGCTAAAC
AAACGCCCTA
AAT1'TGCGCA
AGTTTAAG
ACCCTAAAAA
AGCCTGGATT
TGCGGAACCG
GTGGAGCGCA
TTAATGGGCG
TI'TATGCGTG
TTTGTGGC
?TTAGAAAA
ACCCTAATCT
CAAACCATCT
TGATAGAAAC
ACAATAACCA
CCQTTAAAGC
TAAAGAAATr ?rI'rACAGGC
TGTTAAAAT
TrTrTATTCA
TCACGCATTC
TGCGAGAAAA
ACGAATGCT
CCAAACCCAA
TATrG'I'1AGA
CTTTAAAGCC
TAGACTATCT
CTAACATCCT
GGGGGACCC
AATGCCGGGG
AGAAATTTCA
GTI'TAACGCC
TAATCTCTTA
CGCTITTAAC
CCTCTCI'IA
CACGCATGCG
CCTACCCCCT
TCAAAATTAC
CAG?1'GCTAT AGGGI?1TITr Trr'rrrAAAG
CATTCAAAGC
AGGGGTAAAG
AAIIAATTAAC
T-17i-AAAA
TTTAAAAGCG
TAAGGAGGTT
CAATCCTAAC
TTGCGCATAT
TGGCTTTAGC
120 180 240 300 360 420 480' 540 600 660 720 780 840 900 960 1020 1080 1140 1200 1215 GGGTI'TGATG AGCGA INFORMATION FOR SEQ ID NO:1202: SEQUENCE CHARACTERISTICS: LENGTH: 1239 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Hlicobacter pylori S(ix) FEATURE: Z NAME/KEY: misc.fieature LOCATION .1239 POUS 9 6 /0912 Z IPEIVIJS 18 DEC 1996 863 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1202
AAGGGGTTAG
GGCGGCGCTA
ACCCCTAAAG
TCACGAT'AG
TCTI'CAAGAG
GGTTAAAA
AA.ATACTATA
GGGGCTACT
ATCGCCCACA
CI'TIACACA
GATGAAAACA
AACCGCCTTA
TCCGGAAGTC
TI'CATACAAA
AATAACAAGA
GTGCGTTTG
CAATCCATGC
TCTAATGCT
ATGCTCCCCA
ATAACAGCCA
CTACTCCCCC
G'I'I'TAGTGA
CCCCACCTAC
ATTTATCCAC
GGTTrAAATC
CTCCCATAGG
GTATTATCCC
AGGATAACAT
TAGGTCTAT
CACTTTCTAT
AAATCTrAGA
ACAAACCCTA
TCCCTAACGA
AGCCACCCAA
ACAGAGATTA
TI'TGI'ATCA
GACTTCAAGG
AGGAATATAT
GCATGGCATC
TACCACCTAT
TTATrrAAAAA
TACTCTI'AAA
GTGGCAAACA
CAATAACCCC
TITTACAAGGG
ATGCTCTTGT
TTATGTGGCA
TAACAAAAAA
TI'CCAACATA
CCAAGTTAAG
hIWITAGATCAA
GCTI'CTI'AT
TCAAACTAGC
'TTTTAAAGTC
AAGTI'GTCAC
TAGCTCTAAT
ATATGATATI'
GGCI'ATAAT
ACGCAGT1'AT
TACGAGAGCA
TAATCTATI!A
CAATCAATCA
ACAACAAGTC
TTTGTTTAA
AAAA.ATTATG
CGCTACAITA
GTGTTGCTCC
ATI'GCTGAAA
ATTTATTI'
GGGGGCGGAA
ATACCCCCCA
AAAATAGAGA
GAGCAATACT
GGCGGGAAAA.
AAAACGCTAG
ATATACGAGT
AATTATGTITA
ATGATGGACA
GT T3CCrrAA
CTAAATTCAA
TCACTAAATC
CAAAAATACG
ACCCAAACCC
AAACCACAA
AAGATI'TAGG
GCAATAAAAT
AAAAAGGCAG
CAAAGCATGC
AAAGGCTATG
AATITITTATA
CTACTTAA
CTTATTACGA
ACAACCATAA
TCGTCCG'TI'
TGAAATTrC
GGGAACTAAT
ATAAAGAGGG
CATATAI'CC
AATACGGAGA
GTAAAATTAG
AACCTATAAA
AAAATCATAT
AAAAAATCGC
TAACCGCGCT
GAAAATAGTC
TGCTGGATT
CCGCAGCATT
CArTI'ATT11
CACCAATCAA
TTAC LTATTA AGAAG?1'TCA
ACAACAAAAA
AATCAATGAG
TGATTrTA
TAAAGAATT"A
AACTTGGATT
T'rACATTCGT
TATATCAAAA.
AGCTG3GATCC
CGTATTAAAT
AAAATATCTT
TTATTCTTTA
AAAAAATATC
CAGAGACTTT1 120 180 240 300 360 420 480 540 600 720 780 840 900 960 1020 108o 1140 1200 1239 INFORMATION FOR SEQ ID NO:1203: SEQUENCE CHARACTERISTICS: LENGTH: 591 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE; NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: risc-feature LOCATION .591 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1203
GGTGTAACTT
AGCT1'GAGCG
TATCAACAAG
GACCTITTATG
GCTAGGGTGT
AATITGCTCA
TI'CGCTCTAG
GATGTCAATC
GATCGCAGTG
GTAGCGCTTA
TAATI'CAACA
CGAGTI'TAGC
GTCGTTATG
GTTTAAr'r'
ATCGGCTTT
CCTATGGCGG
GTCTCAT'rGG
AAACCAGATTI
CGTTTGAAGC
TCCGCTACTA
AGAAGGATTTr GTrAGCTGGC CCCTrATAAC CAAATrAGGT AGATTG3GTT
CGGTGGCGAT
TGGCGTTCAA
CCAGTTCTTA
GGGCGTGAAA
TTCTrGGTAT ATTATGATTA AAAGAATrGC GAAGTGAATG GGTTTTTCAT AGCAATTACT CTGAT'TGGCG, TrrGTAGGCT 'I GCCAATAA AACACTr1CAG GGACTGAACA TTGATTGTCA ATCTCATTCC TTAGCCGGAA ACACTTGGAT TGGAAT'rrAG GCGGAAGAAT TITCCCTATGG ITAATCAGGG GTGGAT'ATG TCTI'CACTT
TGTATTTA
GGGTGCGGGT
TCATGGCA.AT
ATGGTTTGGG,
CACCAAAACC
TTCGGATAAA
GTTCCCTrAT
GCGTGTTIGGG
TAGCAAAGAT
C
120 180 240 300 360 420 480 540 591 INFORMATION FOR SEQ ID NO:1204: S(i) SEQUENCE CHARACTERISTICS: LENGTH: 1098 base pairs TYPE: nucleic acid PCT/US 9 1PEvLj I.
6/0O91 a 63 UCE0iS 10 or 8646 STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (geriomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc..Eeature LOCATION .1098 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1204 TTTCGCTrTI'
AGCACACTTTI
AAGAAAT TAG 1 -111 TAAAA
TTAATGTTTA.
GTGCTCGTI'I
TATTGTI'C
TCTTCAACCG
GGAAAGAGCG
ATTTTGACGA
ATTTCACCG
ATCTTAGAGC
TTCATTGTGG
GCGCAATTAA
GTGAGTI'TCT
TTI'AAGACTT
AAAACCGCTC
GCGCTCGCAC
ATTTCTI'TAA
ATAT'TGTTAT
ACATGCCCGT
TTAATGATI'I
TCATAGGCAT
TTG4GCTT
TGGGTCTC
CCATrGTGTI'
CGGTGGGGAT
?I'CTAGGCAG
GOATI'ATTr
AAGCCAAAGA
GCOCGGCGGG
GCATGGCGAT
AAAACCTCTT1
TCATGGAGAA
TTATCATTTIA
TTTCTVTGGC
CAGCTCT
ACCAAATCGA
TGCCGGCTITA
TATCATrGGC
TAATTGTTG
TGAGTI'TAAT
ACAGGTrGTT
GCCCATTT
GAAAI'CTTr
TTTGATITTC
TAAGGATrCT
AATTCTTA
CACGCGCTTG
GTTGAGCCAT
TI'CTAAATCG
TTTIGGCCCTT
ATTCTI'GTC
TGCGCTATTG
GCAAAT CGG
TCCTACTGGG
TGGCTTGCTG
TACATI'TGCA
TCTCATATI'G
TTTGACAAGC
T1'ATGCGCT TCCCTYGTvI
GAAGATITCCA
CAAGATATTG
CATGTCAATT
TTATTrGCCTG
CCTGAAATCT
rrTTrGGGT
CGCTATAAAA
TTTCATTA
GTCATCTTI'
CG7T=lTA
GAGTTI'CTI'
GA.AAGG -1r
TAGGCTTTGG
CAGGAACGGT
GTGAATTTGG
TCAAGTCCAT
TAATCGCTIT
TAGGCATOG
AACAGCTTAG
CAGCCATCC
TGCTCATTCT
AAAAAAAAGG
TATAGGCAC
ITI'CTATGTC
TCAATGTCCA
COATAGGOAT
TACTCATr 'r
GAGACGCTAA
TCGTGATCTI'
TATGGTAAAC
AATCTTTTA
CTTAGCGGCT
TATCGTCTTT
CAAACAAGAA
T1'TATTGGGG
GCTTCACTC
CACGCCTATG
CATGCTrI'TA
TAAAACCCTT
GGCTAATC1'C
GGTTTTAGTG
TTTG3GGGGCG
AGAAGAATTC
GCAGATTAAT
AGTGATGAGT
AACCGCCATC
TI1TAAATTCA 120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1098 INFORMATION FOR SEQ ID NO:1205: SEQUENCE CHARACTERISTICS: LENGTH: 726 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc..feature LOCATION .726 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1205 TGTTIATGCG TGGCGGAGC GCTTOCGCAT ATAAGCCCTTI TGAGTATAGA ATACGCAGCG ~CCTrrTGTGG GCAATGCCGG GGTGGCTTA. GCGGG2'rrOA TGAGCGATGA ATIATITG tGCGCTTTAG AITrGCGCTTA TATCAAAGGG 'TTrAAAAAGC ACGCTCAAAA TTCCTATTAT rauI/fus 96b"/0912.2
GGAGATGAAA
TATGAAACTI
CATTAI'ACC
GTTACCCTCA
CGCATTAAAA
AAAAATCTGA
AAGCAAGAAG
AAAACCCCCA
CTAATCGT
ACGCCT
AAOAGATTGA
TTAGCGACTC
AGCCTAAAkA
ATCACTCTCA
GCATGTTTAG
TTCGTTTIAA
CXITTAATC
CTATAGGCAT
CATTGCATCT
CACCTCATCT
GCTTIIITTTG
AGTCTATAAT
AGTGAAATG
CCCTAGAAGT
AGAGGAiiii1
GGTGGATAGC
TTATTTGA
TAAAGAAA.k:
TTAATCAGCG
CTCTCTAAAG
'PTAAGCTATC
AAACAAATCA
AATCATO-CTA
TTCACGCATI'
TTGAGTGGAT
GGGAGTGTCG
GAGCTGACGC
TAGAGGGTAA
AAAGGATTGA
GGGCGAAAAT
ACAAACAAGA
AGGATTTAAA
TAAACACGCC
TTTGCCA.AAC
CCCATATC'TT
TTTATCAAA
TGI'GAAGGT
AGAAGCCC LT
CAAGCACGCC
CGCTATCGI'
AAATTTACAA
TTGTAAAACC
AGCCAGCGCT
ACAAAGCGT
IFCTCTCAAA
INFORMATION FOR SEQ ID NO:1206: SEQUENCE CHARACTERISTICS: LENGTH: 957 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc..feature LOCATION .957 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1206
ATCCTTCTTG
TTTTI'ATCAA
ACGCCCACCA
ATAATCAATA
TTTGCCTTGT
GCTGCTGCTA
CCAAAAGACG
CAAAACGCCC
GATGAAAAAA
AGTGAAAATC
GCTATGGCTA
?I'AAAACTCA
CATCAATTCA
AAAAAAGACA
CAAGCCTTAA
ITri IrrCA
TTGAATTAAA.
AGATGAGGGT
ACAAACCCC
ACTITCAATCA
TAATCGTAT
ATCTCACGCG
CTATI'AACAT
CTTTTGAITT
TAACCCCI'T
TAAAAATGGA
ATCCTAAACT
CTCCTAGTCT
TCGCCACCAA
AAAACCTCTC
TCATCACTAA
GCCCTAAAGC
GTTACACCCT
TTTAGAGTGG
TCAAACTTT
'TrTAATCAAA
TTTCTCAAAC
CGCITTTAAA.A
TAGC 'TAAT ATrCATI'rCA TAA6AGAAGAA TTCTrI!AGA.A
AGCCCCTTAT
TAAATCTAAA
AAACGCTCAA
TI'ATI'TCATC
AAATGGGGCT
TAGAGCTATC
AAGATCGGTT
AAATATTGGT
AAAATACAAA
GGGAGTTCTA
GCTCTATTAG
GCCCTTGTTA
TCTTCAGGCA
GCGGATATIG
GTCTATGCTA
ATTCTTAAAG
GGAAAAGCCA
ATCATTTATG
ATAGGCTTTG
ATTGATAAAA
AATAACCCI'D
TTTAAAGAAT
A'TT1'CTAA.
TAAATACTGA
T1TTTTAAGAT
TGAAAAACGC
CGCAGGATT
AAGAATI'1CA
AACTCTACGC
CTAGACCCAA
AAGGCGTGTI'
ACCCTAAAAT
GCATGGA.AGT
GCGCTICTAT
GAGCGI'ATC
CCCTTT1ATAA
TAGCCAAAGT
ACGGCTATAT
AAGATTTAAT
TAAGTGGGAT
ACAAATAGGT
TTITCAAAGCG
AAAAATCGCT
AAAAGAACAC
TCAAATCGCT
AAAACTTTAT
GGIITATOG
TAAACGTATC
CTTGGATCGT
TTCTCAAGCC
VTTGATCGAT
CCCTATI'GAA
TI'1TAAAGAT
TGTGGAT
120 180 240 300 360 420 480 540 600 660 720 780 840 900 957 INFORMATION FOR SEQ ID NO:1207: SEQUENCE CHARACTERISTICS: LENGTH: 684 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO PCTUS 9 6/O09i IPENS 18 DEC1996 866 (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-Eeature LOCATION .684 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1207
AAAAGGCGAA
TTGATTACCA
AAACGCAATC
CCAAGCGTGC
~TITACAAG
AGCGTGATT
CCCAC'TCT
TTICTCCTAC
CACACTATAG
AGAGTGGCTA
CAATACGCCT
AATAAAAAAC
CAATGGATCA TGAGTITTG CCCTI'A'ri~Ir ACTCCCTATA 'T1'TAACGAG CTI'AACAGAA TAGGGTI'ITA TC'rrCTrA ATGTGTrAAA TGTGAAACTC TTTCCTTGCC CTTTATGGTA TAAAAGAAGC CAGTTATAGC TCCCTAACAT CAAACCCAGT GTGAATTTGG CGTGGTGATG GCATrACGAT CTTAACGAA TAACGCTCAC GCTTATTAGT AAAGCTCGI' TI'rA
ATTACCATGC
GGGATITI'r
ACGCIGTGT
ATCTTTTCGC
GT TTTTAGTT
AGCCCTATTA
TTGGGTAAAG
GTGTTGATGG
ATGCTTGGGG
GCTGAAGCAC
TI'TAGCCTCT
GTTTGAGCTI'
TAGGCTAI'rr
ATATGCCTITT
CI'CTTCT
TCCAAGGGCT
AAAGCGCGT'
GGGAATACTA
CTATCATTAC
GTGATATAT
TCAATTATTC
TGTT'GTTAC
TTCTTTAGCT
T'TTAAGCCT'
AGTITI'IACCC
TIrCZGAGCG
TATCTTAGGG
AATTTCCTTN
CACCCTTTT
AACTITTATG
AGGGGAAACA
TAAAGCCCAT
CCTATrTI'A INFORMATION FOR SEQ ID NO:1208: SEQUENCE CHARACTERISTICS: LENGTH: 561 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc..feature LOCATION .561 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1208 AA'TI'I'ATfl 'IT 'TTATTG
AGCACTAAAG
CCTAAACAAG
ATCGCTTCTA
TAGATGAGA
ACCGATGAAT
GTGAAAAACG
GGCGAAAGCA
GTGGATGTCA
r'GGAGAATr
TAGTTGGCTG
CGGTTCAGAC
AGCCAGCTCC
TI'TATTTMrA
TCGTGCAAAA
TTGGCTCTAG
CTI'TAGTCAT
AACCCAAATG
AATTAGTGAA
TATAATGAAG
TAGTCATAAA
TGCGCCTGT1
AGTGGTTGAA
ITTTGACAAG
AGCTAAAGAA
CGAATACAAC
TAAAGGGGTA
CGTCCAAAAA
G
AGATCTTCTG
ATGGATAATA
ACTACAGAAC
GAAAAGCCGG
TATGAGATCA
AACCACATGC
CAAGCGCfl 4
Q
GAAAAAGATA
ACTAGAGAAT
AGACTGTGGC
CAGCTCCAGA
CTM'ITGAAAG
AAGAATCCGA
AAGTCCTI'I'
GCGTTAAAAG
TGATCAAAAC
GTACAGAGA
CTGGTAGCT
TGGCGATGTG
GAAAGAAGAG
CGGGACTATC
TCAAGAGACT
GGAAGGCAAT
GACTTAGC
CATCAGI'r1
AAACAGAAGA
120 180 240 300 360 420 480 540 561 INFORMATION FOR SEQ ID NO:1209: Ci) SEQUENCE CHARACTERISTICS: LENGTH: 603 base pairs TYPE: nucleic acid
PL~
1 .9/9 IPENJUS 18DE(C'19 867 STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii-) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .603 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1209
AAACGAATCA
AAGGAGTGGG
GTCATCGCTI'
GTCGCTTI
AAAAGAGAGT
TGGGTGAAAC
AGCGI'GTGC
AATGTTTTT
GATTGGGTGA
'rrrGTTCTTA 'rrr
AAAGAGGGT
GT1'ATCTI'AT
CCATII'GAG
TAGGGAATT
TTTAAAGTA
GCTACGCCTT
CTI'TGGCAAT
CCAGTT
AAACGCTGTA
TAGCGCTITI
TITrrATGCAA
'TTATITITG
CGCTACCACG
AATAGGGAGT
TTCCAAAAG
GCTCATGAI'
TGGTTTTAGC
GTGGGCGTTA
TGAAAGGCI'
AATATGGTTT
GAAGCGTTGT
TATTCC'I'IGG
CACGCTITTGG
GGGGCTCTTG
CATAGAAGAA
TTTIGTCAATA
AAATACCCTT
ATCGTGGGGA
TCTCATI'ACA
TTATTGAAAC
TGCGm'TTCA
GGGGTGGGTA
ATATAAAAAT
TAATCTrI'GC
AATATCTCTA
TAAAAAAG?1'
GCGTTTCTT
CTTCG 11711T
GATATI'CGCG
AGAGGGCTr
TGTAGGGATT
AACCATCI
CCGCTATCAA
GGCGAGTTTG
TGGGATTAAA
TITATGGCTT
TCAAGCGAGC
TGTCATAAGT
CAAAATGGGT
INFORMATION FOR SEQ ID NO:1210: SEQUENCE CHARACTERISTICS: LENGTH: 1182 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc..feature LOCATION 1182 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1210
GCTAGTTA
AA'FITrCTCT
TCTAAAGGGC
CTGGTGGCTG
CTGGITTTCTA
ATCCTCATGC
ATTGAAGCTT
GCCAAAAACA
TTGTATCTCA
GCGCTAACAA
iTGAAACTCC
ATI'ACAATT
TAATCATCGC
TITAGTTTGAG
AATACCCAAG
ATGTGTTT
TTTAGCGTG
CACTCATCAC
ATCAAATTAC
AAGTCCATGC
TCATCATTTA
TTAAAGAGCA
TCAAATGTTA
TCAAAGCTTG
TGAAATCTI'G
CGGCGTI'TA
AATCGCTAGT
GGGG'ITGTAT
AGACATTAAG
TTATT 'GGGC
GATGCTGTAT
TI'TTAAAGAA
AGTCAA.AGGC
AGGAAAAACA.
CCCCATGCGA
CTCGTGCAAA
GCGGA~TTGA
?TTCGTTTG
GGTTTGTATA
GAAAACAAAA
ATGATTATAG
GTCGTGGGGA
AAAGAAGGGG
AGTCTTAAAG
TTrAGCTrA
TT
T
'AACCCC
CCTfTTrAG
TGAGCCGGAA
TGCTG TT
GCGCATGCTC
AAGA'ITTATC
GGAGTTCTI'
TTTT TTTAAT
ATTTTAAAAG
AGCTTAAAGA
CTAT3GGGCG CTl'GTTGCTT
TTI'ITGCGTG
TGATAGTTT
TAGCGGCACG
CAAGTITA
GGGATCGTTT
CATGCTCTGT
CCAAAAAAAT
TAA.CCCCAAG
120 180 240 300 360 420 480 540 600 660 r T!S 96IO9l2.2 IPE18U EC IJ C.ITAAAATITr
ATGTGGCAAG
ATCCT'I'X
AAAATCGCCC
ATCCC?1'ATT
TATTGC'ITGG
TCGCTTTTAT
CAGTI'GCGTT
ATCCTCTIT
T3TTAGTGGG
COGTATTIW
AAGTGATTTIC
TGAGTTCGCT
GTI'TCATAGG
GGTATCAATIT
cAAGCTGTGT
ACTI'CTCACC
TCTTTGTA
GCATTAZT
AAAACAAGGC
CATCCTcATT
TTTGGTGTTG
GGTGTATGCG
CTCCAAATT1C
GCGCGTGGTC
CCTAACTATC
TAAGGCTAAG
ACGCCTGTCT
GT1'AAAGAGC
CATTITAA
CTAGGCGTA
CTCATGGTGG
GTTTCTAAAA
TCTGTGCTAA
ATAACCATGC
CCGTTTIGATG
'TTTTATGAG
AATACCIITr
AAGCCAAAAA
GCCCCTTGTI'
CGT11rTTGc
ACAACATTTC
TCTTGTCGCT
ATITTTGCCCT
AG
CCATTTCCAA
TGTGTI'CTAT
TTACAGCCAA
GCrrAGCAAT
TTACATCAGT
ATCGCTCTCA
CAGTAGCCTA
AACGC TATC 720 780 840 900 960 1020 1080 1140 1182 INFORMATION FOR SEQ ID NO:1211: SEQUENCE CHARACTERISTICS: LENGTH: 261 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (gerioiic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .261 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1211 CGCAGAAATC ?1'ACTAGACA. ACATGGAAGT GTTAAAAAGC CATGCGAGCC TTTGCGATAG CGTGAGGAGC GGTAAAAGAT ATCACCGATA TTGTCAATAT CGGTATTGGG GGGTCAGATr ACCGCCCTAA AACGCTACGG CCACCCAAGA TTAGAAATGC GGCACGCAGA TTrTAGACGT T
GTGAGAAGCG
TAGGCTATAC
TAGGCGCVTT
AT11'TGTGTC
TTTTAAAACG
CAATCPLAGTG
AATGGTTTGC
TAATGTGGAT
INFORMATION FOR SEQ ID NO:1212: SEQUENCE CHARACTERISTICS: LENGTH: 222 base pairs TYPE: nucleic acid STRANDEONESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature 7 LOCATION I 222 2) (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1212 ACATATC CTAATAACCT AAAAGATATA GAGATGAATA CAGA.AAIWITr AACCATCATG 1 IJUU IPEA/U3 9 U -i k2 18 D E C 1 TTAGT GTCT CCGTGCTI'AT GGGATTGGTA GGCTAATAG AGCGGTCAGT*TTGACGATGA AAAACGCATG C CAAAGCG GAC =GAACG AAGCGATTr ACAAGAAAAA CGCCAAAAGA INFORMATION FOR SEQ ID NO:1213: SEQUENCE CHARACTERISTICS: LENGTH: 726 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicrc ra (ix) FEATURE: NAME/KEY: misc_-" LOCATION I1.. .72( (xi) SEQUENCE DESCRIPTION-
CGTTTTTATG
TGTTGTATGA
AT
GGGGGTrAAA
CAGCGCGAGC
CAAATGCAGT
GCTCTATI'AG
TTGATTGAAT
ATGCAGTTTG
GTTGATGGCA
ATTTATGTCA
TTAATGGGCG
CTCTTGCCGG
ATGAAGTI'N'
ATCGGGTATG
CAGTI'GAATI'I
GCGGTTAAAA
CCACTC
TTTACATGC
CGTTCTITAT
TGTIATTGGT
AAGAAATGAA
TCGCGCTCTT
AAGAGCGTCG
TGI," :TTC
TTTTATACCT
TCCTCTACAC
ACTACGCCAA
TTTCTAGCGG
TCCCGCTC?1'
GCATCTT.
GAGCGAT
c I-GTT
AGAA'
?TrrGl
TAAAGA
TCTTA)
CATCGC,
CTI-I=AGCG
TAATTACGGC
GAI!AAAACC
TCCCI!CACA
'CATCGCC
;CAGGC
GTTGGC
GTCCGTG
,AAGGGATC
GAAATCTCG
CTAT1TCTGGC
CATTTTATAC
AGACTGGTAT
AATAGGGAT!
TCTAACGCCC
120' 180 240 300 360 420 480 540 600 660 720 726 TCG?1'GTGCA
ATGATGAGTT
TGGCTCTT
CATGGCTGCC
±~i~mcAAAAT
TGC'TITAGG
TGATATVIT
TAGCTTC'
TTATGCGTAT
INFORMATION FOR SEQ ID NO:1214: SEQUENCE CHARACTERISTICS: LENGTH: 1488 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL- NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc..feature ST LOCATION .1488 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1214 POTUS 96/091a2 IPEA/UG 18DEC3%,,b
AAGAGGTCTC
AGCATTT'AC
TI'CACTICCA
GATTITTAG
CTAGATACTC
TCTTAGCCC
TACTI'GTITA
CTrATTGGGT CGCTACGGcT
TTGCTATGG
ACCCTATACT
IvrTAGATrG
GATGTGTATG
GCTGGCTTTG
GTAGAAGACA
TI'ATGGCAAG
GCTTTAGCGT
TrCATGTTrG
GAAAAAACAT
ACCCACCCCT
CCTTTTAGCG
ATrCTrAG
TGGCTCGTGG
ATTTACACCC
TGCTI'GTTCT
T1TATGTrAAT
CCATGCTGGT
GGTI'TCGCG
TGGTTTCAGG
TCTCGCTCAT
TI'ICAAAAGA
TTGTCGCTG
TAGAAACAGC
TAGAAGCAGG
GCGCGATGGC
TACACACTGA
GAGCGATTGG
AGGGCAATAA
TGGTAGCGAC
TTTTTTATGT
AAGATGTCAA
GCGTGTTTAT
CCTrCACI'A
GGGATGAACG
TAGTGGCGAT
TGTTrGGG;G
CGGTGGTGAT
CGATGTTT
AAAACGCCAC
CTGTGTTI'AT
AGATATI'CTC
GTTGGTGTGT
CAATT GAAT
GTI'AGAAGAG
CTCTCAAAGC
ACGCTICAAC
CTTrCAGTTC GCC!IT GCCC
GATCAAGTAT
T TTTACCTG
GGGCATCACA
CTTrTAAGGTT
CCCAGTCITTT
TCGCCTrTr TI'TGATCC?1'
AAGGATGCTC
CCACACTGAA
CATTGGGGCT
CTACGATCAC
CTrGGGCGCT
GAAATTTA
GTTAGTTAAT
CAATAAGCCC
CATGCCCATT
GATGCGAGGG
CACATCTC'T
GGGGGGA'IT
GTGTT LTTAT
CXAGAAAACG
ATI'GTCTIGA
GATTCAAA
ATGGITI'CAA
CTTTGTGTGT
TTCACCATGG
CTTACAGGGA
AACCCCATGC
TCTITAGTGC
GCGAGCTATA
GGGGCGTA
ATGACTATCA
GCTTIATAGTT
GATAGCCAAC
TTGGCCIWIT
CCCTATTCTA
ATI TGTT
GCCGTTGAAA
AGCGCGGTG3
'TACAAACCC
TATGCGGTCA
CTTAGAGT
TTGATAGCTT
TCACGCTCT
GCATGCTCT
CC TTTTTTGG
TTTCAGCT
CCGCTGAATr
GCAACCAGI'
TAATGGCGTT
GGGCGATGGC
GCTI'GAATCT
TCTTTGCGAT
C?1'TCCATAC
TTTCCATTGT
TAGACACTCA
CCATCCCTAA
CTATrCGCA
AAGCGATGT'
TATGGCTCI'
AATTCAACGG
TTGGGCTTGC
GCGCGTTAGA
CTGCGTITA
AAAGCTACGC
TIATTGCCAT
TTGTGGCT
TAGT1T1'GAG
AATCAACGCT
TTrGGTTTTG
GTTI!AAGC
TTCTCATT
TTAT1'CCCTA
TGTTGTAATC
GAGCGATAAA
GAGCGCGTT
TCAAGTCATT
GGGCACTAT
CTGGATGCCT
GCCTAAAATC
TACCGCTTGG
TTTCATTGCT
TrCTGGG?1'C
TGTTTATTGG
AAAAAGCCGG
CC'ITATCAAA
AGGGATCCCG
GAGCAATCAC
TTArTrCCGT
TCAAAACGAT
GGCGTrAGCG 120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1140 1200 1260 1320 1380 1440 1488 INFORMATION FOR SEQ ID NO:1215: C(i) SEQUENCE CHARACTERISTICS: LENGTH: 888 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genemic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc...feature LOCATION .888 (xA) SEQUENCE DESCRIPTION: SEQ ID NO:1215
AATCCCGCTC
GGCTCTGTCA
TGCTCCCGC
CTGTGCATGA
ATCGCTTATA
CTI'GAAGGGG
GGATCGATCG
AATGTGGGCA
TTTGCCACTT
TACATGCTCA
TAGCTGT
TTTCCCTTCA.
TGCITI!CAGC
TCATTTATGG
GCTCTrCTC
'TTCAGGGGC
TCGCTGGTAT
CTAAAAGCGC
TGCC TTAAG
ACCCTCTT
CTTCATATAA
TTGAAGATTT
TTTAGGGAT
TAGAGGTGAT
CACATGGCTG
CTTGCTTI'CT
ACTCAGAA
AGG1TTrCTA
GCACATGGGA
GGTGTITATG
CTTGGAAGAA
TCCTGTT1TT
CA?'GG~T'T
GGCTATCAT
AGATGTGITC
AAACGCTCGT
TrATCCTAAA
AGAAATCCGC
CCTTATGCGT
AAAATGGGGA
AT77TATTTAA.
GCCTACGCTC
GTCGTGGTGC
ATGTTTGCGC
CGCGCCAGCA
GCAGCCT TTT
GTGGGAGAGT
GCCGGGACAA
TITIGGCAACT
GAGGTAGGGG
GCGCTTTTAA.
TCGCTCC ?I'
ATTCTAACGC
CTTACGCCIT
CCCCCATAGC
AAA)AAATT
TrGGGG 'rrr
ATGGCGI'AT
GTTTAGAAAT
TrATGATCGT
TTTGAGCTT
GCATCATTCT
TAAAAACCGG
'1-ITrAAGCGT AACCGAT 'GA
TTTTAGGTTC
CCCCACTCTh
ATIACGCI'C
CA71TGTGGCG
AAAA.ACCCTC
TrCTrrCAAT
CGTCATGGGA
CGCTCGCTTT1
TTTAATGGCG
GTITAGGGITTT
ATCAGCGGTT
GAACAACCAA
GAITI'TAGCT
GCAAGGCTT'
ATTGGACACT
120 240 300 360 420 480 540 600 660 720 780 840 POUS c 1PEN["'Ug3' AAGATAAAAG AGGTCTCTTA TGTTAATAGA TA'rrCTCCAC ATCTCTr INFORMATION FOR SEQ ID NO:1216: Ci) SEQUENCE CHARACTERISTICS: LENGTH: 1404 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicebacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .1404 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1216
A'TIATTCAA
AGAGGCATrI'
GGAAAAATCA
GGGCGTrr=
GATTTAGGGC
ATCCAATGCC
TTTAAAATCA
ACGCTTTTAA
GCCCTAGAAG
TACAAAATCG
AAGGCTTTAA
CACCACCCAG
AACGCTATTr
TCTCATCATA
CAAGGCATCA
ATCAATAC'I'1
CTCAAAGAAA
CGCTATTro
GAACAAAGTC
CCTGAAGA.AA
GAAGCGCTrA
GGCGT(GAGAQ
TATI'TAGTCA
TTGCTGGGC
AAACAAGGAG TCATGACATG ACCCCACCAC TI'TAGATGAA TGCGAGAATA CGATAAAAGC TGTTI'GA.AGT TI'TGAGCGCG TAATCCCCAC ACCGGTAGCG CTAATrCCAT CATGATCACT CGCTCAATCA AAACCCGTITT ACGCAAAGCA TGAAATAAAG CGTATCATCG CTATISATC CCCTGGATTI' TGGTAATGGC ACAT'GA?1'T TAGCAGCCTT ACCCTAGCGA AGCGAAAAAC TAATAGGCT1' T<GCTTI'GAT TCTATGCGGG CGATGAATTA CCCCTToT GATCGGCGAA TI'GGTAAGAC GCTCATGTAT CTAATGCGCA T1TTGCGGCT GCTATIGATGA CGCTCT~IrAC CAAGCGACTT GGAAAACACC AAATCGCCGT GACCGAAGAA AAAACCCGCC AAGCCAT1'TC TGGTi TTGA ACATGGCTITT GCCGCTI'rGA AGGCAAGGAT TATTAGAAAA ACTT'
GACATI'AGCA
A.ATACGGCTr GTGTTT GTAG
GGGCTGCCAAT
TAT'ITTGCGG
GGCTCTCACA
TATGGCAAGG
CCCCTAAAAG
AAGGATTA
GTGGGGGCGT
TATAGCGATC
TTAAAAGACT
GGCGATGCGG
GCGAI'ITrAT
GTCA.AATGCT
AAAACCGGGC
GAAATGAGCG
GCATGTTTAA
ATI'AAAAACC
GAAAAATTTG
CCTACAATCA
GGGCTI'ATTC
GAAACAACAG
TrT=AGAGA
TTA:GTATCGG
GGCATGACGC
CAAGCGGC-r CCI'rTAATGA
ACCCCAAAGA
ACATTCAGGC
AAACGCCAGA
AGCATTTAAA
TAGGATrAGA.
CTGATGGGGA
TAGAAAAACA,
ATAGGATTGC
TCGCTAAACG
CTCAAQTGAT
ATAGCAATITT
GGCATATCTT
GGGCTT=GA
TCCCCTATTC
AAATCAI'CG
AAGAAATCAT
GCGCAAGCAA
CGI'rAGAATA
ATACGATATT
CGTGGAGT'rG
AAGGGTGCAT
GAAAGTGTAT
A6ATAGACAAT
ATACAACGGC
T'ITAAAAAAC
GAAAGTCAAT
AAATCTrAAA
GCCGATI'TA
TTCCTAAC
CATGCGAGAA
GATGCTAAGC
CTTGCATGCT
GTATAACGCA
AAAAATCAAG
TITTTAAAGAA
GTTATTGCTT
CTACACCACG
CAACTrACAA
CAGCATTGAT
CACCACCCCC
TAAAAGGGCG
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1140 1200 1260 1320 1380 1404 INFORMATION FOR SEQ ID NO:1217: Ci) SEQUENCE CHARACTERISTICS: LENGTH: 642 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genornic) N(iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO POT/US 96/09122 1PE/U3 180EC 1996 872 (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc..feature LOCATION .642 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1217
GGAATTA
ACGGCGTTGT
GAATTGTATT
GGCATTATCC
ACTI'ACATGG
GGCGTGAAAA
CCI'TAAAAG
TTAGCCAAAC
TATAAAACTC
GCGCACATGA
AATITGCGA
TGAATGAGAT
A TTTAAAAA
TGTTIGGATAA
A 'GTGCCGG
?I'GAGAATTT
AAGCCATTAA
AGAGCGATTTI
TCTCTGTGAT
TAGTGCCI'G
TACCAGGGCT
TGTGGGGCGA
CA'TITAATC
AAACAAGCCT
AGACAACGTT
GAGAGTGGGG
ACTCATGGGT
TCTAGCGAGC!
ATTGAACGGC
GAAGTATI'GC
TAACCTIAT
TATIGCTAGG
TGGCACGGCC
ACCGGCGCTT
GATG?1'ACCT
CAAGCCTAT'
GGCATTGTGG
TrGTATCT'I TCTrGCGCTT
TCTTTAGAAC
GAATACGTGA
GGCGAGTT1I
ATGCACACCG
GAAGAGAGTA
ATGGCATCGT
TACTCACCCC
TGAAAGAATA
CAAACATIAA
TTTCTAGCGC
ATCCTAAATA
CAACGAATGA
GCGCTGAAAA
ACAAGTTTGA
CTAAAAA
TC
GGGGCAGAAC
TAAAAAGAGC
CAAGCCTACA
CGATC'TrTCA TTTAGAT1TW
CGCCCCTAAC
AGGCTACGCT
AGGCG'TTTT
AGAA)).GATA
AAATGAAAAA
120 180 240 300 360 420 480 540 600 642 INFORMATION FOR SEQ ID NO:1218: Wi SEQUENCE CHARACTERISTICS: LENGTH: 1215 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-.feature LOCATION I .121S (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1218 GCTCACGCCA ACCGCACCAT AATGCCATYC GCCCCATGCQ AACGCTCTT T1AATGCGCC 'ITTAGCI'DAC TAGATAGCGA AGCGTITTTAG AAAATGAAAA GATTTCAA6AC CCACGCTCFI' GCTITrTGATr TTAATACGCC AGCGTCTrAG ACGCATTATT TOGGACOGGA GTC.GGGCTIA TTGGAACGCA ?I'GAAGAAGT GCGATCAAAG AGCCTAGAAG CTTTTfAAAAC GCGTrCAAAA CATGACAAAA AAATCAAAG GCGTTTAGTT TGGGCGTGGT GAAAATCTAG CCCTACAAAG GTGGTGCGTT TGAAGGAATT AAACGCATCG CTAAGAAATT CCITAAAG GGCATGTCGT VIGAACAAT'rAG CCAAGCGATI'
CATCCACAGG
TTTlGGTTAGA
CAAAAAGATT
AACTTCTGTT
ACACTTTAAA
AGC?1'GCGAT
CTTGTTGCA.A
ACAAGATCCG
TGAAAATAAG
GGCTAGATTT
ATTGGTrrrrA
GCATTTCAAA
CGTCOCCACC
GGGAACGATT
CGATGAGATC
TTATCAAGCG
TTTrAACAGC
GGTGTGCAGT
CAAAAAGCT
ATTGATGATA
GGGrI'rGCCC
TTAGCCCTTG
C'TTTACTCT
GAAACTTT1GA
GAGCATCAAA
GTCCAGCACC
CATTTAAATC
ATTTATGGGG
GAAGAATTTTf
GAAATCGCTT
GAAGACGAAT
AATTCCATAG
AGTITTTGAAG
GCTITTTACC
TTTGAAAAGG
TTAGTAGAAA
GGGGGCGTGT
CAAAGGGAGT
GCATCGCGCA
CCCTL'TACCT
GAGCGGAGCA
CGCCI"rT*T ATrTI'rTCTT
ACTACACCAC
ACCATGCCCA
ACCCCTTTAT
CGGAGTGTT
GGCTTAGG
TAAAACACCA
TAGGAATTTT
GGCGTTTGTT
CCGAGAGCGG
CTTTGAAAT
ATTTGGGCGT
TCAT'TACCGC
TTTGCAACCA
AT'TTTTCCA
GCGCGTGGAT
CACTTTACCC
AAAAGGGCAT
TGGGATI'TG
AAAAACCTAT
CACCAAAATG
CTI'ITTAGCG
AGGTATTGTT
TGTCGGGGAT
GGGGCAAAAA
GCTCA.ACAAG
TAAACAAATG
TGATATAGTG
GCAGGTTTTA
CAAAA.ACAGC
TTAGAACCC
TTTGATTGCG
ATTGTTGTGC
CAAGCATTIC
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1140 I PEA/ U 18 DEC 1996 CCCCCTAATG ACAGCAGTAT CCCTGTCGGT CAAGCCTTAA TGGCGTATrI' CAACCCTACA ATCATCAAAA AAGGA INFORMATION FOR SEQ ID NO:1219: SEQUENCE CHARACTERISTICS: LENGTH: 1338 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1 .1338 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1219 1200 1215
CGCTITIGAGT
TATATGTG
ATTAACTGGG
ATTACCATT'
ATrTCAGCTr
GGGGCTAAAC
ACGCTGATTA
TTGATTCAAG
CATCTTGGAG
TCTFI'CTTGC
TATTrGGGC
CCTAAAGCGA
ATGGGGCTTr
AAGATTTCA
AGCGCGATTTI
ACCATI'GCTG
ATGACGATT
GATAAAAACG
TTTGGCTCTG
GCTGCA=TGC
TTGGATATT
ATTGAGAGCT
GCGGAGCGAG
GGGGGCTTAT
TITI GTGGC
CAGATTATTT
TI'GTGAT1"IT
TCTTI'GAACC
TTGTTTCTTA
GGCTTI'TGAT
GGATI!GGAGA
AAGGCTCTAG
AACCCCATAT
CCACTATTGG
TAGGCGTTGC
TTGTAATGAG
TAGCGGCGGT
AAGATITCTA
CTAGGCTT1TC
CTAGCATCCT
TGATITGTT
TCTCT2GGGC
ATCAAATCGT
CTAGCGTG
TAAAGCAT
CGACATGAGC
CAATTCACAC
TAAGCGCTTA
TGAAACGCGC
AATCTTAAAG
GACCTrI'GGC
CACCTTITTTA
GATGAGCGCT
GGGGATI'AAA
CGTAGTCGCT
TI'TAGTGCGC
GATTTC?7GG
T'IATGTACAT
TCAATrGCTC
GATGAGCACG
TGCGACGATr
GGTITTAGG
CAGCATCGTO
TTCACTITI'r
TAGCACGGTG
TCCGGGCTITT
ATCAGGCACT
GGGTGGCTT
ATCOCCATAG
CGCATTTATA
TTTAGCGATIG
ATTTTTTATT
ATTCAATACA
GGAAGGTATA
TTAATCGTGG
ATCATTAAAG
ATTATI'TCAA.
TTCATGTCTA
ATOGTTATT
AAATI'rGACT ?1'DAACCCTT
GCCAGTTCGC
TI!CAATAAAA
GTCGCTTGCA
AG~rACGCAT
TGGTCAAGAA
ATTTTIATACG
ATTIGTAGCGA
AAAGAGGCCT
TAiTGGGAT'
GCTTGAGTT
CGAGCGT'GAT
ATAAACACAT
TI CTTCAG CCTACGC'ITr
AGGCGGTGTG
TGCCGATCGT
AGATCAAGCC
GCCTTC
t
TCCGCTCCAT
CTTAATTGG
TGAGTI'TAGA
GGATCACAGG
AACTGCTTGT
ACGCCCCCCA
TCGCTTTTT
GGGCTGGCTI
1
TGACGCGCAT
ATAAAT'T3GG
GCGTAGCTAT
TTQ"AACCAT
ACCGGGAGCT
GGGCGCACTC
CGCTAATTCT
CTI'GCGCTTG
GCTACTGAGT
AAGCATI'GGC
CTGGACGGAT
TATGATAATC
TGAAAACCTT
GGGGTTAGGC
TAGAGATGTO
GGCATrzCGTI'
AGACCCTGAA
CATTTTATTG
AAGCTCTTCT
AAAATTAGTG
CATI'TCAACG
TGGCGCGAGT
TCGGCGCGATr
CAAMAGCTTT
TGTrCCGTTI'
GCTTAAMGA
120' 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1140 1200 1260 1320 1338 INFORMATION FOR SEQ ID NO:1220: SEQUENCE CHARACTERISTICS: LENGTH: 1125 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) N(iii) HYPOTHETICAL: No ANTI-SENSE: No 7e PCT/1iS a,906/ 09 122.
IPENIU3 18DEC 1996 874 (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .1125 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1220
AATAAGTGGA
TCTII'AATCT
GACGATGAGG
AACACGGAAA
TTAAAAGCCC
CCCATGGATC
CTGGCCTCTC
TI'CCCTGTGG
GCCACTAATIG
TI'GATI'ACGC
ATITITGCAA
TACAGCAACA
ACTCCCCATG
AACGGCTTAG
CITICTACGC
AATAAAGAAG
AGCGOCATGG
CCCATI'GTGG
?I'CCCTATAC
TTAAAGGGGC
ACCACCAAAA
TGAAATACCC
GCTCCAAAGA
TAAACTCCAA
CAAAA.ACAAC
GCATCACCCC
ATAACCCTAA
AAAACAAGCT
CCATTTCTAG
GCATGvGGCAA
ATAACAAAAT
GCATI'AATAT
TGGGGGAATI'
TCACTAACGG
AGGTGACTAA
GGATCAATCA
TGATTAGAGA
CCAGAGAGAA
aoTG rmr
GCCAAAAGCC
CTTACAAGAC
CGCTACCATC
AGAAATGAAT
CCCCCCTAAA
Tr'CAAGCAA
TGGCATTGAT
'ITTACGCACC
CCAGATCGCT
AGCCGTCTI!A
GGGCGAATAC
CATGCTCACT
GATI'GAAAGG
CCTATTGA'IT
TTrCTTGG
AGTGGTCAAT
GGGGAGTAGG
TGAAGTCATC
GTAGGGGGTT TTGCAACGAT
CCCCTAAATA
TACACTI'TCA
AAAGCCTI'IAC
TATTCCAAAG
AAAGACTTT
AGCCCTAAAA
AGTTCACTA
A'ITACAGCTG
GGTAAAGTGA
ATCCCCAAAG
CGCTTGGATA
AACGCTALAG
AMTTCCAAC
GGGATCACT
GAT!ATCTTTI
CAAATl'rrAA GTCTTCATIwl
GCTGAGIT'
ACCAGCCTAG
CTCAAAACCC
AAGAACAGCT
AAGAGACTT
CTCCAAAACA
ATTACGAAGA
ACCI'rAAAGA
ACAAAATGAT
TITGCGCAAGT
GCTCTAAAGT
TTGTATGGAG
GGGCGGACAT
GCTATGGCGT
CGGCTTTAAA
TATI'GCAATT
GAGACAAGAG
CGCCCAATAC
TGAAG
TACAACCITTT
CCTITI'GAAT
ACAGCCAACT
CAAAGCCGCT
TACTAGCCCT
ATTAGATTT~A
AAACCTGAT!
XAAAGACATC
ACCCGCTITI'
GGAGAGCGAT
CATAGGCTAT
TCGAATCATC
TAAAGGCTAT
GCCGTrACTG
CAACAGAGGC
GATGAGGCAA
CAAGATCGCC
TGACATCTC
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 112 INFORMATION FOR SEQ ID NO:1221: SEQUENCE CHARACTERISTICS: LENGTH: 363 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicebacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .363 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1221
AAAGCGGCGT
TAATCAAGC
AGAGCGATGA
GTGrr TI'CC CTAGGG".7TA
TGGGTAACTT
TTA
TITGTATAGG
TITATITTGCA
ATAlwrTATrrA
AATCTATTCA
TCGTTATCCT
ACCCTATTGC
GATTI'TC
GCCAAGCGAG
TGTGGCTAT
ACGCACTAAA
AT1TGCCGATT
GCAATTTTA
TATGGCGCTI'
CAAGACGCGC
GTTTTTTTIAG
AGTTCGTTTA
TTAAGTCATT
GCCGTI'TG
AI'rATI'TCCT
TCTTTATGCA
GCATGACTTT
TCATCACGAT
?I'TATGGGGT
GTAGCGTTAG
AGATGAATTT
AGAGACTAAA
G'rrGTGCGCG TrCGCACACG
TAATGGCAI'
GGGTAACTTA
INFORMATION FOR SEQ ID NO:1222: PCTZA 96/0912.2 IPENUS 18 DEC 1996 87S SEQUENCE CHARACTERISTICS: LENGTH: 390 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .390 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:l222
ATGCTCAAAA
?I'CATCCCI'
TTrGTGGGCA
TT'TCCAGGAC
TATTTTAG
TTTlGTCGCTC GCGCGTTTr
AAAAGATTGA
AAAAACTGGG
TCATTGCGTA
GTCAAAATAA
TAAGCGCCTT
TGGGAGCAAT
'rrrGCATAAA.
TATGATCTCA
TAAAGAAGCT
TGAATTGCTT
AACCCATAGG
TATTTTGAGC
GACGCTTI!AT
GATTCTATTA
CITCTACTT
ATCGCTGCGG
TTrGGTITG
GCTAGGCT'G
ATGGCGTI'AT
GGAAGCTCTT-
ACTCTATGGT
TCAATATCGC
GGGCAGCGAG
TGTI'TAGCAG
TGCCTTTrAG TI-ITrATIAC
AGATGACATG
ATGGCCTATI
CATTGTGGGG
CGTGTITTAT
CGAAAATATC
INFORMATION FOR SEQ ID NO:1223: SEQUENCE CHARACTERISTICS: LENGTH: 483 base pairs- TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc...feature LOCATION 1. 483 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1223
AATCATI'ITA
AATGACAAAC
T1' TECAATT
ACCGTGATAG
GGGCAGTTGT
GGTGTGCCTC
GCTATCATGC
GCCAT1'ATCT
CTT
ATGGTI'GTGT
GCCGTT?1
GGCATGCGAT
ATTTATCAA
AAAGCACGGC
ACACGGCGGG
TTITITACGAC
TTTTAGGGTT
AGCGATGGTA
TTTT GTGTTG
AGGGGTTTTA
ACGATICT
GGAATTTAGC
GGAAAGGTTT
?TTGTTTGCG
cAGCACCTTT
GCGATGTTGA
GAAGTGG=G
GTCTI'AATGC
'rATCTTCAG GCTT1CTA'ITA
GTGAGCATGT
ATTTCTCAAG
TAGCGGATGT
TTGGCTCGTT
TTCAAGGCAG
AGCATTTTFIG
TCATTTCTTC
TGATTI'IATT
ATGGGATCGT
GCATCCAACC
CTITTGTGGTrG
AGCGAATATC
CGCGATAGCC
GcCAAAAAA
AGCTAAAAGC
GT11'AATACC
TATGTATAAT
GATGCAGAG
120 180 240 300 360 420 480 483 INFORMATION FOR SEQ ID NO:1224: POUS 96/091 2.
1PENS 18 DEC 1996 876 SEQUENCE CHARACTERISTICS: LENGTH: 1278 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (geflomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1 1278 (xi) SEQUENCE DESCRIPTION: SEQ ID 140:1224
TTI'TI'AACA
GCGGTGCTTT
ACGATTGTCA
TTGGGCAGAG
TATGAGGGGG
ATAGGAGGCT
ATTTCACTTC
TTGCAAAAAT
GTGGCGCACA
GAGXITTIG
TATGCGAGCA
GGGGGGTTGT
GATGTTTCTG
GGGCTTCATT
CTCGTI'AACG
GGGGTGGTTT1
CAAGCCGGGA
TATATGCAAT
AAAGCGATCA
ATTrOGGGGGC
AAAGCGGTGC
TTAGGGATI'
TCTTATIGC
GCGccT~TT
AAATACTGCA
TACGCIITT1
TTATCTUI'GC
TATATTATT1'
GCTI'AGGCAC
CCGAAGCGCC
CGGTCATGTG
TGGGCATI'CC
TGTrCGCTAA
CAGAAGAGCA
TAGCCTTGCA
GGCTTTTAGG
TAGGCACGCT
TTGCCGGGGA
TATTGCCTTA
TCACCTI'I'GC
TrGGCAGTTT
TGTAGGCAC
GAcGATGATI' TTGGcGTTD
GATI'CAAGTG
GGGTrTAGCT
ATTTGOCAAT
GATCAACGTT
AAAAATCATG
?1'CTAAAGCA
CTTAGTCAT
CGTGGGCATG;
TTTACCI'AT
AATCATTTAC
TGTCAATATT
TGTGGGGGCG
GGTTGTAGGG,
TTTAAAACCT
AATCATAGGC
TTTCGGCGAT
G'I GTGCGGA
AGTGCCTAAA
GCTTTCTAAT
T'ITAGCTCTC
TCTOGCAATA
GCTI'lAGGGG
AGCGGCATAC
CTCGCTCCAA
TTAGCGATCA
CCTTTAGTGA.
GAAAGCATGA
AAACCCTATr
GCTAGCGTI'G
TrAATCGCCG ccGCAAAACG
ATAGAAGCTA
ATGCTrAG GGATII'rAG TTGCCTI'rA
ATTAAAATCG
AACCCTCCTT
VrrCGCTAACT AAGAAAGAT1T
TTCATGAGCG
TTTTAGTGT
AAAGGGCTAT
CGTTGGCTTT
AAAGCGTGAT
ACGCTAAGGG
TTATCTTT'rr
TCAACCTCAT
GCGCAGCGGC
TGAAAAGCAT
CGGGGCCTGT
CATCGTTAT
AAACCATTTIC
TCGCTAATGG
CCTI-rGT=G GCAT 3GAGCA
TGTTAGGCGT
cGcTCAATGA TAATCT1TGAG
TAAGTTCAGT
TCATT2CCAG
CGACTATCGC
TGTAGGGATG
AAATTATCGC
ATATGTGCCT
TGGTITACGGC
CGATCAAGGG
TGCTAGCTTG
cGGCGGGGCG TAATATTIr
GAGCGATTCA
GTrAGCCGGG
GTCCGCTCCT
TAGCCATGCA
GGCAAGCACA
GATGCTCGCG
TTGTCTI'rA
TCCTTGGAGC
ATTTGTGGGC
CGAGAAAACC
CGCCATGCTC
aCTTGcTTTA :cGGGTTATTC 120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1140 1200 1260 1278 ATAGGGTTAA
GCGCCAAT
INFORMATION FOR SEQ ID 140:1225: SEQUENCE CHARACTERISTICS: LENGTH: 948 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature PCT/US 96/09122 IPENUJS 18DEC1996 877 LOCATION .948 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1225
ACGCTATCCA
GAATcAGGCT
GTTGTCATTC
AAAATGGATA
CAAAAAAATT
GGGCAAAAGA
OGGCATCTCT
CTCATGCTCA
GAAAGGAACC
cCATTGAACA
TCTAATGCGG
TATACGCACT
ATTGGCTATA
TTTITGGGTA
AGCGCTI'IAG
ATCGTCCAGC
AAGAAGAGGG
CTAAGCAACT
TTTTAI'GAT
CGATGACAAG
ACGCCCTAGC
TCCGTGGGCT
ATGATGAAGT
TTCCTAATGG
ACCCCATTAA
CGCCTGTGTA
GGTATGGGAA
TAGATCATGT
GCGGGAAGAG
AAATI'TTAGA
AAGAAAATAA
TCCAAGAGCA
ATTGATGCCA
CAAATTTrCT
CGTGGGGCPI'
CGAGAGGAAT
GAAAGAGATT
AGAATCCTI'G
GGATTTAGAA
CATGCCCCTA
AAAGATTAAG
TGCGAGCGCT
C "rGGTGCGC
CAATGTGCAG
CGGTAATAGC
CGCAGAAAAA
ATTTATTGAA
TGTGGATAAA
CAAAACCAGC
APAAAATITrAA GGcGTGGGGT
GCGGTITTAA
AAAAACAAGC
AI'GAAATCA
AATTTGAGCT
AAAACTTATA
GGCGT'rGAAT GATGGGAT1'G AT1'GAACATG
CCTAAAAGCT
GGCGGCGAAA
TCCTAGCAT
TGGAAGAATC
GACACCTTAA
TrTGATCAC
AACGCAACCT
TTTTAAAATr
GGGATTTTAG
GAGAAGAGCT
AAAAGGGGGC
TAAATCAAAA
GCGCTATCAA
CCGGGATCGA
TGGATTTTGT
CGT7"rGGTTr
TCATCCAAAA
AA 'DGCATITA
GGGATI'GGA
TGTTI GGGT
AAGGTCAG
CATCATTGAT
CATCXITTTCT
'TrTAATCGCT
GGGTTTGTAT
TTI'TATTGTG
TAATGGGGGA
ACATTTAGCA
ACCCACTAAA
?1'ITATCGCG
GAAGACTCGT
CAGCTCCATI'
AGGGCAGTTG
TGAAGTGCGG
TCATTTT'CAA
TTAGAAGAC
INFORMATION FOR SEQ ID NO:1226: SEQUENCE CHARACTERISTICS: LENGTH: 945 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAM4E/KEY: misc-.feature LOCATION .945 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1226 CGTTATATTA ATGTGCATAT GTGGGATCTT TATTGTTT ATGAAAAPIC AGCATGCTr AAGCTTTCTT TGCAAATGGA AAcGAT1TAG AAGAAGTGGT TITTTCCAGCC GC'I'GGATGT CTTATCCCTA ATGACTACCC AGAATGCACC CTATTGCA ATI'AACACGC CTGTGTATGC AATGGGGGGT ATGGGAATI' GCCCATI'TGA ATAAAATCGT GGGTATAGTG GTAATACAGG TTAGATCAAC CCATAAACCC GTI"ITTAATA AAGAAAGGAG ATGCAAAAAC AGGACCAGCG CAGGCGTI G C1TATTCCGC
AGGCGI'ITCA
AATCACTAAG
TGAGTTrA
GGGGGTGAAT
GGCTGGGAT]T
GCTAGAATCC
TGTTTGCAC
GAGCGCGAGC
GATTAAGG1'
CGTAAAAACG
AAT'GAGCACA
CATGAGTTT'C
CATCAGATGG
ACTATCATCG
ATT'GTGATGG
CAAATCAGTT
TTACTGGTT
GAATTTGAGA
GACGATVITGC
AGGCCTGAAG
ACCGGGCTTC
TATCGGCGCG
AACCATACCG
GGTAGTOG
TT'CCACCCr GGCGAAT'rTG
GGACCGCATI'
ACCAAATGGA
CAATCTITGA
CTCAAGGCAC
TTACGGACTC
TGTATGCGCT
TAAATAAAGA
AAAPAAGAGA
AACTTTCAGG
AAGAAAAAGA
AAAAAAGCTT
TTTCAGCCGC
TAAAGGGAGT
GTTGAGCGT'
AATTAAAAAC
GACGPIATGAA
GGAGCGCATC
AGAGGGCAAT
TATCATGCGC
TTTTAATAAA
120 180 240 300 360 420 480 540 600 660 720 780 840 900 945 GGCTTGATTT AAGCACCGCT GG~rAGCGAG CAAGGGGTGG TTGGTTrrrAA AACCTACTAC TCAAAAAAGQ GcAGTTGATT TGCATTATCA AGTG3CGCTTC AcATGAAAGA TTTTGAAGAA TAACAATAAT AAATCGGCTA
CAAAA
2) INFORMATION FOR SEQ ID NO:1227: POTU~S 96/0912? IPEN 3 180DE S 878 SEQUENCE CHARACTERISTICS: LENGTH: 1380 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (geriomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .1380 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1227
GATATTGAAT
AATT1'GCCCC
AGCTCACTGG
GTCATCAACT
ATTCCTATGA
TrACCTGAAG
AGATTCGCTC
ACTTI'TATCC
AATCAAGCGT
GGCATI'GAAC
GATTTGGGCT
?1'AAAAGATG
CTCAAAAAAT
AAAGAATTGG
TACGATAAAG
CTGAATGAAG
GAGATT1TCA GAGGCTI 'AA
GTGTTGTTGC
CT T1'AAAA
TI'TATGACTT
AACGCTAGCA
AACGCGAGCG
TCGCCAATCT
ACACCAAAGA
CCAGAAAAAA
ACCGCTTGCA
TTCATTGCAA
ACATI'GTGAT
AATGCCCCAG
AATCCAGCTG
TTGATCAAAL
ATGCGATT
ATCITCATII'
GTGCTAAGAT
ACGGGOCTGA
AATGGAATGA
CGAACGCCAT
CGCAAAAAT'
ATAAGGCTGA
ACGCTZ GAA
AAATCTTAGA
GAGAGAATT
TAGGGCTTAC
AAGAAGAGAT
TTAAAAAAGA
TI'ATCATAT'
AGAGATTTTA
AATCCTCCCT
AAATTGGGGG
ACAI'GCGGA
TGATGGGGAA
ATGCCATAAA
GTATTTCTTG
TTACTTGAAG
GCACTGTA
AGATGAGCCT
GAGCAAATCT
TCCCGTAAGG
CAACGCTTTA
TACCCCTACC
AGCCCGCAAA
AAGCGCTITAC
CGCGCA.AAGT
GCCTATGATC
CAAGCCTATA
CATrAATGGC
TATTATTI'TG
AATTTATGTG
CCTATAAAG
AAAAATAGCG
TATI GACA
GTGAGCCGTC
ATCGTGCCTG
GGCAATCCAT
GACGCTrAG
CGTTATACCA
~TATTTCATGC
TACGCGCGCT
T1'CA.AACAGC
AAAGGCAATG
CTCTTTATCC
GAAGGCGCGC
ACTTCTAAGC
AAkAGTCTATG
GCGTITAACA
GATGAGCAAA
CCGCACACGG
GAAGTAGATG
AA.AAGGCGCG
GCTAAAAAAG,
CCTAATA.AAC
TGATCACGCA
GGGAGTGGAG
AAGAAAATCT
AAAGGTAI G
AAACCCAACT
TAAAAAAGCA
TAGAAACAGA
CCCCCAAAAA
CGGTOGGACAC
Trl'TCACTAA
TATCACTCA
TCGTI'AGCCC
TrrrrGCTGC
ACCGGTTAT
CTGAATTI'AA
AGGCGTTGAA
CTFITGATCGC
TTTTATGCGA
CATGGGAATI!
AAAGCGCTI'r
CGGAATTGAA
AATTAGAGAA
TGTAATTT
AAGCCCTCAA
CGATCTITCT
CGGTAAAAGG
GGGAGCGCCC
GCCGGTAACT
TGCGAGTT<G
CACCATGGAC
TCAGCGTGAA
TTATArrIGGC GGCTI'rAAGG
AGGCATGGTC
TAAAGAGATA
CCCGCCGGCT
CAAGCGCTrrA
AGAAGTTGGC
AAAATCGCAT
AAGCTOCATG
GGGTTATTIT
GAGCGAGAGG
GATAGAAGAC
AGTCAATAT1! A-7A'ITAGAA
TGTTACCGCA
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1140 1200 1260 1320 1380 INFORMATION FOR SEQ ID NO:1228: SEQUENCE CHARACTERISTICS: LENGTH: 1209 bast pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genornic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature Ho' %0912a WPEA/US 18 DEC 1996 879 LOCATION .1209 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1228
CTAAATTTGT
TTAAAGGCGT
ATTCAAATTTI
GTGGTAGGGA
CAAGGGTTI'A
TATTTGAATG
TCGCACGCT
CTCGCTAAAG
ACCAACGCT
2-i rrAGGGG
AATATCATCG
AAACACGCGC
GAACGCCACC
GAAACGCTAT
ATCGGCCGTI'
AGCGCTAAAG
'ATAATTGCT
AAAAAGGTT
GGGATTAG
AATTA'TTGG
AAGAGGGAT
OGCTCAAATC
T= AGAAAC
ATAAGGAT'TT
CTAATGGTAA
AAGTGTI'GCA
GCTCTGTI'GT
TCAGTAACGC
ATTGCGATA
TGGAAAAAAC
ATAGTTTAGA
CTCCCCAACA
AATI'GATTGT
AITTAGCCCA
TGCCATIGCAA
GCGAGC rrrI
CCTAAAAGA
ATCAAGATAA
TGATITI'AGA
AAACTTTAGG
TGTATGGCTC
GCTrATGAGG
AAAGCCTAAG
TAAAAACGCT
GGGCAGCACA
TI'CACCTCC
TAAAGAAAGC
TIGCTCGTAT
'TrTGGITITA
CCTAAGCGI'
AAGCATTGCG
AGAACTGjGTI'
GGTTICAAAAT
TI'TMAGCG
TAAACAAGAA
AAGCCCTAAC
AGAAATCAAA
AGACGCTF
ATTGCATAAT
GTTAGAACAC
ATTTCTGTA
GGAAATTCAA
GAATACCATA
rI'ITITGAGA
GGGCGGTT
CCTCATGTI'I
GTTI'AGAAA
TTTGAATACG
GAAGCAGGGC
TCACCCCCA
ACTACTAAAT
TTAAATGTGG
GAAMTI'AA
ATGAATTTAG
GTTTTAAAAA
ATITTAATAG
COCATCrrl'A
TTGGTGCTAG
GAAAGAAT1'A
GCCTTG?'TG
GCCAACGCT
TAATGAAAAA
AGTTCGACCC
TTCAAGCCAA
TAACCCTT
TIGAATI'CAG
ACGCCCACCA
CTACCTTA'TT
TGGGGGA
TGATTACGA
TAAAAGCGAT
CTCAAAAAAT
AAGGAGTGAG
AAGTGGCTCT
ACCTAAAGCC
ATG2TGGGGCA
ACGCTCCAAT
AAATTAAA
TCCAATI'AGA
AAGAACTGAA
'TTTATGAACG
TAGTCATGGG
TAGCCCTTTC
AGTCATTCAT
ATTAGCCGAT
GGAGCGCTT'
GCAATTGCAA
AGCTGTCATG
GITTTGACAGC
TCATAAOGAA
GGGCTCTCT
CGCTAAAGAC
CGAT1'ATAI!
AAAGGCGTI'
CCTAGATA
TAACCCCCAT
CGTTCATT
GTCTGTGG'T
AAAACTTAAA
AOAAAATGAA
CTATCCAAAG
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1140 1200 1209 INFORMATION FOR SEQ ID NO:1229: SEQUENCE CHARACTERISTICS: LENGTH: 681 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc...feature LOCATION 1 681 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1229
AGCGTGTCCA
ATGAACCCCA
CCTTTATACC
ACCATICA
GGCGTGTATG
AAAAGGGCGA
CATGCGTGCG
GATTI'ACCCC
GCGTGTTTAG
AATGTGGCGA
CATGACTTA
GTCATAGCGG
TGCAATTAGA
ATCAAAGTTr
ATTGCTI'AGG
ACAAATCCTT
TGGTGGTTAA
AATTGAAAAA
CCTATGATTT
ATATTTTAGA
G ETTGTTGTA
GAGCATTAA
GAGCGCGGAT
AAATTGCT'C
TAAAAAATCC
GCCTI'TAATC
GTGTAAGACC
TGGAGGGGG
TAACGAAATT
GAAAGAA 'A
AAATAAAGGC
TTIGAGCCAT
AAACCAAAGC
TGTPGAAA
AAACAATCGC
GCCCCmTAA
AACCCCTTAA
ATGGCGCTAG
ACAGATGAAA
TTAGAGTATG
CAGA'TGA
AAAGATTCGC
AGGGCTAAAG
GCA'rrATGTG AT1'TGGGCGT ATr'rrGGGTT
GAAA.AGAGCT
GGCCAAAAAT
CGTT1AAGGC TCGTGrI GCA
ATTTGAGCGC
ACGCCA.AAGA
ATACAATGGT
GATTTAAAAG
CATTACAAA
GAATATTGAA
TTATTCGCG
TTTCACTAAA
CCAGCTTTA
'rrTAGGCGTT
TGACATITACG
TAAAGATTTr
AAGCGI'CAA
GG [TGCGGCG
AGGGCGTGAG
AAATCATAAG
120 180 240 300 360 420 480 540 600 660 681 GCTAAGCCAT GCCTAGCGTG, T INFORMATION FOR SEQ ID NO:1230: POT/US§ .N9 09122.
1 EI -j'U38D E C 1996 SEQUENCE CHARACTERISTICS: LENGTH: 882 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .882 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1230 ANT1GTAG
GG'TTGAGT
AAATTGGTTG
GTGTI I ATG
AATAAAGTCC
GC LTCAGCGT cTAATITATG
GCGTTTGTGG
GCGGTGATGG
AAGCGTI'ACA
GCGATTGTGC
TATAAGCGCA
AACGCCTIAA
GAAGACGCTC
GTI'TTAGATT
TGAGTGI'CC
TGAA??I'ACG
GGGAGGGTGA
AGATITTAAA
CTATTACAAG
TrGCG I 1"1T
AAAACCACCC
AAAAAAAGAA
TGATCCCTAA
GCGTGCAAGA
AAGGGAAGTG
TGCAAACTTA
TGAGCACGCT
CTAAATTAAA
TTGACAATGA
TGCAACGAGT
CAATCGTTT
AGGGATCCCT
AAAGCATGGG
GGGCATGG
AGGGTTTGCT
GGATAATATC
AGTGATAAGT
TAGGGTCAT1'
AAGCGTGTTI'
GGACTTGTTG
TCCCGTGTTG
TTCAGGGAGT
GCAGG'rrrra
TGGAGTCCTI'
GCGAATTTAG
TTTATI'GAGC
AAA? TTTTAA
AATGACGGCT
TCTAGCTCAG
TTTGATAGAG
ACCCCGGCGG,
TTAAAAACCA
TCTACCAAGC
AACCTrI'CGC CGTI'G1 GTT
TTTCGATCC
GGTrCGTCGT
AGCA.AGAAAT
ATI'GAGAAAG,
GCCCCGOTTT
CTAGTAATAT
CCAACAATAT
CGTTTAAATI'
CGATGATTGT
AAcATICT TGI'rGGGGG
AAATCCCT'C
AATCGCGCCA
ATGCGAGTTT
CTAAAGACAG
AAAAGCTCGC
TTTTTAACAT
TCCCTAAATT
AC
TGATTGCTTG
CCATOCGGTG
1'1'1CACCAAA
TTTATTGCAT
GGGGGCGGTC
CAATACTGCT
GTATAATIGCA
TrrrrrAAAA
TCTCTTGCCC
GATGACGATO
GATGCACCAA
TTTAGAAAAT
GTGTIATGAA
TAGGGTAGCG
120 180 240 300 360 420* 480 540 600 660 720 780 840 882 INFORMATION FOR SEQ ID NO:1231: SEQUENCE CHARACTERISTICS: LENGTH: 894 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-.feature LOCATION I1.. .894 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1231 'ITAGTATrCA AAAAGCCCT TI'TAAAAAT AGGITACTAA ACGTTACTAA TAAGI'AAAA TI'GGAA TAACCATAAT GATITAAAGAT TITAACCACT AmrTAGAAA AATAACGAGA I=TTGTAAAAATTCCCAC CAAAAAACAA GGAGCAAAAA AGATGAAAAA AGCGGT 'TT1 PUT/US 96/091??2 IPENS 16 DEC 1996 CTrTI~rTGG CGGCGATGGC TTGCGTAAGA TTGTrI'IGA CCATGCATAG AAGTCAAACC TTGCAATAT
TGI'GATGCC
GATCCTTCTA
CGCCTAACTT
KAATACGGAA AACCCATI'CC CGATCGCAAA ACCAT =CA CTGGATAATA ATCTAAAAAA GGGCATAAAT
ATITGGCGCG
GTCATGCTTG
CTAAAGAAGT
GTGGTGCAAC AGAGCGATAA TTAAATCGCG CTI'CAGCCGA
TATCATTGII'
GAAATGTTTG
CGACGCCGGC
AACGACTCAC
'rI=IACT G
TGATTATGCG
CATCCATAT
TATCAACAGC
TCGGGTAACA
GCCTAACGCG
CTCCTTTGTC
AGAGAT1'CAA
GTGAGTI'TAA
CCTAAT1'ATG
TATGTGGTTI'
ATTAGTGGCA
TCATGGCAAG
ATCTCTTTGA
TCITTGCAITA
CGTTGGTCGC
GAGAGCGAAT
CACAAACGCA
TTGTTAGCGA
GATCATGAAT
ACGCCAAAGA
AGAAAAATCA
TAA.AAGATAT
TTGAAAACCC
CGCGCGA'TI'
CGATCAATI'C
GCC'rrGATGT
CATI'ATCAGG
TAGCGCAAAA
TCGGGAGACTA
CACAATI'IAA
GCGCGAT
TCcGAATGTG
AAATCCTTCA
TAACGGTCCG
TTTGTTGCTT
TATGAGTAAA
TAAAAAAGGG
GCGCAAACAG
TGGCTT'GAAC
AAGCCCGTT
TGGC TrGGCG
CCCATTGACT
GCGT
INFORMATION FOR SEQ ID NO:1232: SEQUENCE CHARACTERISTICS: LENGTH: 363 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc..feature LOCATION .363 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1232
TATCATCGCA
AAACGCAACG
TATGAATGGA.
AATCT1AC
TCTTTGGTGC
AATGTGGAT'
GCT
CTAATACCAC
ACGCCTACAC
ATGGAPATGA
AAAATGGGGA
TTAAAAAAGG
GTAAAGTGGA
GATAAGGATA
CTACCATGAT
AATTAGTAAT
CTCGGTCATr CACTAAA6ATC
AGGGCAGAGC
ATTATCATGC
GGCACGCAGT
GAAGAATTGA
CTCATIAAAG
AAAAATATCA
TTGTCTTTAA
AAGATTTACC
TCGTTTGCTC
TCGTrAAAGA.
ATTTAAAGGT
AGCTTGTCAA
AATCTAAT
cccATGCCCT
TAGCTGTTIG
TTGCCATAAT
TAAAGGCTCA
TAGCGATCAC
CCTTAAAAAA.
INFORMATION FOR SEQ ID NO:1233: SEQUENCE CHARACTERISTICS: LENGTH: 225 base pairs TYPE: nucleic acid STRANDEDNESS: doublo TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc..feature AAPC;*:r?7 Qt2.T PGTUS 96/O91Za IPEAAJ 18DEC1996 882 LOCATION .225 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1233 AAGGGTTG'1T TTATGCGAGA ATTTTTAAG AAACTTGGCA 1-17rIGG'IT1 ATTGGCTTAG ATGGATG'G AGTGCGI'GG GTTTTTrATT A TTCAATT TCCGTGTGG CTCAATCTIT GCGGTGATTT PrrTCAAGTT GGATAAG ETG ATTrTCTA CAGAATACCC TTCCAAGCTG TGATGCTGCC 'TITTATGGAG TCTI'AGGGCA AACCATTGGA
AAAAA
INFORMATION FOR SEQ ID NO:l234: SEQUENCE CHARACTERISTICS: LENGTH: 1492. base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori
FEATURE:
NAME/KEY: misc-feature LOCATION 1 .1491 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1234
TTCTTTAAAC
TTTTTGCCTT
CATGTGGGCG
TTCATTCAAG
GGGAA'TTTA
GTGGTCACTC
ACAGGGTTTA
GTGTTGAGCG
TACTTGCTCA
T1'TGTGATGA
AATTTTGGCA
ATGCTC'1T1 ccTATOCACA
CATGCAGCGA
AGT(3CGGTGT
GGAGCGAGCA
TCTCAAT1'AG CACCTCTTT1A
CATGCGATGG
ATCACAGCTG
GGCTATTCT
TGGTTGTC
CTGGTG I7I'
CATGCTTG
GCCGTTTTTr
GCTATGAAAG
TAATCGGTGC
T=~CAATTC
CATGGCATCA
AAGTCGGCT1'
TAGTTCTT
ACCGCTATT
ATAMITI'IT
TTGGCT'r
ATCGAATCAC
CCCTCCAGTA
ACAI'AGCGT
CATGG~rAGC
CGATGGTAAC
TTGAAGTGGG
TGGCTrTAGT
GCTATATGTT
CCCATGCGTT
AAGACAATCT
TCT'ITATGAT
CCAAAGACAA
TTTTGA'rTGG rI GCACCCAA
AGCATGCTAC
CATTITATCT
GTI'AAGCATG
GGTTTATGCG
TrI'GTGCGTG
TCAAAGCTAT
TTCCCTCATG;
CTTAGTGCAT
TTCCTACC?1'
AGGGCTTTC
GTATCATAAA
GGATI'TAGGC
TAAAGAAGTC
GTTTC 171-1'r
CAACGCTATG
CGCTCQGGGTG
CAATAAGGAT
TGTAGCGGCC
CTTCAAATCC
GGATATTACT
TATAGGGTCA
GATI'TTAGAG
GGCGATCTIT
ACAACATGAA
CGTTAGGGGT
CTCAAGTGAA
C.AATATTCTI'
GGCTGTTI1G CTGGTTTr
GAAAAATATI'
CTGGATAATA'
GTGTATI'1CTA AGCGGCTI G
ATTGGCTGGG
AAAAGCGCGA
ATGCTCATG3Q
TTTAGCATGC
ATTGGCGCTA
GAGGGGCCTA
TATCTAATCA
GCATGCTI'AG
TTAAAACGCA
GGGCTTGGGG
CTCCTTTCT
AAAATGGGCG
GTGGCTT'I'IQ
GTCGCCTrIG
ACCGCTTTI
ATCAACCACC
TITrGGCGGTC
?I'CCTAGTGT
:TTTGCTGTC AGTGGTGTTG GGCTAAAGC TAAAGCGTTG rCAT wGGCG GGTGGrCTT rGTTTGACTG GATCGTGGTA rCAATIGcGGT CATGATrGTC TAGGcTATAT GGAGCATGAT rGTTTTrCCAT GCTGGTGTG A.AGGGGTGGG GcTATgcTCT NTAACGCTTC TATI'GAAGCC GGATTATT GATCTT'1TG TCAATAACGC CGATrATTCC TGGGGAAGAG TGCTCAA?1'C CCCCTGTATC CGCTCTCATC TCAGAGCCAA
TCCTTTGTAT
GAGCGTI'TGT GGCTCTlI' TCGTGGCTTA 'rrCCACGCTT cTI!ATQcGAT CGCGCTTTT'C TAGQCTCAQG
CAATGTCATG
CT'ITATACAA GCCTATGAGG GTC;GGATCTA cCCrl'rGCG GGATGCACCA ccACATTI'IA ATAGC CAG ACTCATCATG CCCATGAAGG
CCAAAAATTT
A ,GccGGTT TIrCAGAAGA TGGAGAGTAT C 120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1140 1200 1260 1320 1380 1440 1491 INFORMATION FOR SEQ ID NO:1235: Ci) SEQUENCE CHARACTERISTICS: LENGTH: 828 base pairs TYPE; nucleic acid POUS 9 6/ 09122 IPEAsIJS 18 DEC 1996 883 STRANDEDNESS: double D) TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .828 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:123S
AACAAGCCGA
AAAACAAAGA
AGACAGAGGT
GAAGCGGGCA
AACACCTTGC
AAAATGTTGC
GCGAACGCT~
T
AAAATCGTAG
GGGAAAGACG
ACGATCACTA
TATGACI'OA
ACCCACAAAC
TATTTCACTA
AATAGCGCTA
ACAAGGGTGC
AGAGAATAAA
TAAAGAGAAA
TCAA'ITTAGA
TAGTGGTTGG
G TTTATTAGC
TAGGCATCGC
GCAI'CGCGC
CTGTCAGTAA
ATGI'GAAGG
GCGATATCAT
TCCCTACAGA
ACGACAGGGC
AAGAATCGAA
AGTATTGGAG
ACAGAAGCGG
AATTGAAGTC
AACTTATGAA
CGAGGAAAT
CCAAAAAAGC
TTCTATITGC
TCAAGGGGAT
AGTGGATT
GCGTGTGTTG
GCAAGGCTT
AGCGGGC2T
TAATCACAGA
GCCACAGAAT
AAAACAAAGA
CTGCCCCAAA
CCTACCAAAA
AAAATTCTCG
TATAGCCACA
GCTAI'AAAC
GAATTGAGCG
TTCACTATCA
ATTCTGCCCA
CCCTTAAAAC
GGCTTTGTGG
AAAGCCTTAG
GGCTATTTAT
GCGAGCCTAT
AGAGGCAGI'I
AGAAAATCAA
CCACTTACZ'
CTCT TTTGCA
AACAAGCCCA
TCATTCTTAT
AAGAAGTIT*
ATAGCGACGA
GTCTCAACCA
CGGCTTTAAG
AAGAAAACCT
AGTrTTATCA
TAGGAACAAG
CAAGCCTI'
GCTTCAAAAG
ACAGAAAACA
GTT GCTTGAA
AAAATCAAAT
TAACATCGCT
CCCCCCAAGC
TGAACATGAA
TAGGGrI7r
ACTAGAAGGC
GTTTGAAGGC
CACAGAA TGC
TCTAACCAAC
CCATI'TGAA
120 240 300 360 420 480 540 600 6 &0 720 780 828 INFORMATION FOR SEQ ID NO:1236: Ci) SEQUENCE CHARACTERISTICS: CA) LENGTH: 669 base pairs TYPE: nucleic acid CC) STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: CA) ORGANISM: Helicobacter pylori (ix) FEATURE: CA) NAME/KEY: misc-feature CB) LOCATION 1 .669 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1236 GGAGG7TTTA
GCGACCGAGC
TAGGGCTTA
CAACTCCCCT
GGCTCTGAAA
AGGATCATCA
TTGGGGCGTT
ATGGGGAATC
TGGCCAAACA
AGTI'AAAGA
CGATCAAGGA
TAAGCCCACG
GGTGTATAGG
CGCATAAGGG
GCAT'ITATTG
AGAATACAAG
CACCATTAAA.
ATITTAGC
CTATCGCGCG
CTGTGGGCTG
CGAAGACAAC
CGGG'I GTGT
CGCCAGCACC
CAAC?1'CCTA
ACGAGCI'GG
CCA.AGCGTAA
GTGCATCATr
TGCGAAAAGA
CGCAAAAAGA
GCGGAAGT
CAACGCTCCC
AACGAGCCGA
GTTGGATCT
CCATCCATrA
TGCAACGGCT
TTITGCACGAG
TCGATTCTI'A
GCCCAGAATT
AATACGGCTC
AGTCCATAGC
AI'CAAAGGG
CCCTATGGAG
TTTAGACTCA
cAACTGCATA
CACGATCAAT
GGCGATCGTT
TAAAAGCGAG
120 180 240 300 360 420 480 POUS 9 6/ 0912Z2Z IPENS 18 DEG'1 u TTCTAACGA GCGAACAAGA CGCTAAAAAC TGCTCGCATG CCGAATIWITIT GCCGTAAGCC CTAATrATAA CGAACGCATG CAAGCCACCC CTTTIAGAI'A CCTCAAAAG AAGAATCCAA AGAAGAGTCT CCAACAAGCC CAGAAAGCCA GA.AAA.TG'r INFORM4ATION FOR SEQ ID NO:1237: SEQUENCE CHARACTERISTICS: LENGTH: 624 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc..feature LOCATION 624 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1237
AGGCTI'GGT
TGTCCAAGAA
TAAGGGAGAT
ATrATGTCCA
OCCATAAGG
TTAAGCATGG
GCTAGTAGCA
GTGGTGCAAA
TTTCAACT
CTTTCATTG
AACCTITCTA
ATTGGTrATG
TTAGTCGCTA
ACGCAATII!A
AGAACCTI'CA AAAGAAGAAT AGATGAAAAT GTITGAAACC CG?1'AGTGGT GATCACAACC TCGTI"1'?IAT TTCTGCTIT TCACGGTGTA TGTGGGTGCG CCGCTGCAGA AGTAGTTGAA GCGTGGCGCT GTTGCTCACC AGCAAGTCAA TICCAACCCT TGcTrTrCAC CAATTACCTC TGGTTGGAGG CATCGCTACA TAAAGGAATC TCTA
CCAAAGAAGA
ATTGCCT T
ACAAATATCC
TTCTTTTrAC
GTCATTGTGA
CGCAAGCAAA
'ITGAT1'TTAA ATTGATG3CGC ATrCCCTTTG
GGGATTCAAA
GTCTCCAACA AGCCCAGAAA ATrrCTI'rGC GATCCTITACT TCTATIGCCAT TACCGCTCTC TGGACGCTGA GT" ITC TGTATGCGT TGGCATGATG GCCCTAAAAT CTI'GTGCGT1' GCGCTCCTAG CATTGGCGAA AAATCCCTAA CATTAAAGCG AAGCGGCGGC TTrAATGvCTr AAATCCATGG GAAAAATCAC 120 180 240 300 360 420 480 540 600 624 INFORMATION FOR SEQ ID NO:1238: SEQUENCE CHARACTERISTICS: LENGTH: 738 bass pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION l. 738 (xi) SEQUENCE DESCRIPTION: SEQ ID, NO:1238
APNUS
0 &/912.
8 DEC 1996 ATGAAACAAT TTAAAAAGAA ATCVI'AAAGC GTCCTTTAT1G TATGCGGATG3 GAACAGACAT GTGCATCGTC CATGGTATGC TACAGGAA ACCAACTCAT CACTCTCAAA ACAACCAAGA TI'AAGCGGTC TGTATAACTA ?I'AGG/CAGTA ACGCTACTTT TATCCTAATG GGCATACTGA GTAGAAGTGG GCAATCGTGT AACT GAACG CTAATAAGGT GTGAATGTAG GCAATGCTAA TAC TGCAGT TCTTTAGC ACCAA. AAG
GCTTIATGCCT
T7rIGGGGC'T
TATATGGAGT
CACAAAAACT
CATCACACCC
CACCGGAGGG
TAATCTAGGT
TGTTAC LiTTi
GGGATCGGGA
TACTATCAAT
CACCGTTATT
ATAAAACGAT
TTACTGAI'G
AGrlrGGGGGG
TGCGATAAAT
TGGGCAGGGG
AATTTAAAAA
GAATATAATIG
GCGAGTAGTG
AGCGCTGGGA
GCTGGCACGC
TCCAATATCA
ACCAI'AATI'
CGCATCAAAA
GCGGGTITGC
AAAAAAGCCA
GGGAGGAAAA
GTAATGCGC
ATGOATAAO JO
GGGGGAATT
GGAATAGCTT
CTATCAATIGT
ACACCGGCAC
GCGCGTATAA
CGGTTCTTT
TCAAAAAACA
TAGTGGGGIG
AAAGGTATIGC
AACACAACAA
TAACTACTAC
CAC'ITAI1-
AGACATIGAA
CACTTCTTGG
GAATAACAGC
AGCCAC TTA
AACTTCCCAA
AAATGGGGAA
120 180 240 300 360 420 480 540 600 660 720 738 INFORMATION FOR SEQ ID NO:1239: SEQUENCE CHARACTERISTICS: LENGTH: 1200 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .1200 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1239
GTITI'CACGC
GAAATCTI'AA
TGTrI'GTrCA
TA'TTGCAAA
ACAGGAAGCT
TTCAACGCGC
AACCAGAAT
GGCGATATI'IA
GGCGAACAGC
.v ;ATGATT
TATGCCCCTA
ACTTTAAAMG
AAGGTTAG
TTAGGCTTAG
CGT1'1GCAAC
TI'AAAGGGCA
GTAACACCGG
GACGGGG??1'
AAATTGAAAA
CAAGCCACCA
CAAGGGTGAA
ACACAGAATI'
TACTCGTT
CCGCTAA.AGA
7rCGGGAAAAC
ATGCAAGCCC
TAGACOACAG
AAGAAATCAC
ATITAGAATA
CCAAACGCTT
AAGATAGCCC
GCACTTCTITr
GGGAGTTTAA
AGACAGAAAG
TGT1'GGAAGC
TGTAGAGGG
GATTAGTGGA
TGATGTCGC
CCCCCCAAAA
CGATTCAAGG
GCGC~rIrrC
AGCCCCTTTA
GAGCGCTTCT
TAAAATCGCC
CAGCACCAAA
TAAAAGTGTC
GAGTGAAATT
CCGTCTCATr TrrrAAAACT
AGAAAAAGCC
?l'TAATAGAC TGAAACGCTr
CGCCTATAAT
GATCAAACGG
GAATCAAAAA
CATITCGTTTA
AAGCAATACA
TATCATCACA
AATCTTACTC
CGATTTGAT
ATCTTCTAT
AATGGGATIT
TrAATCT1'rG
TCTTTAAAAA
AATTTCTTGC
AACACCCTTr
TATATCGCTG
GAACCGCACC
TTAGAAAATA
TTTGCTACT
TATTCTAGCC
ATCAATGGCG
ATCGCTTCAG
CTrGTVIWITG
ATCATI!ATAG
OCGAGCTTGC
GAAAGTAATG
GGGGAGTTGA
AAGGATAAGG
TCCTC77ITI'
CGCTCGCGCT
AAAAAGTC'r
ATTTAAAAGT
ATCAAATCTT
TAGGCATrGC
AAGCTGGGGC
TTGcCGTGGT
'TTCGAGAC
CTGTGGAAAA
TAGTTAGAAA
T1'rGGGAAAG
AGCTTAAGCC
ACGATAGCTT
ATCAAGGGCG
AGGC?1'TAGC
ATICCAAAAC
CGCAATTGGA
AATCTTGCAT
GGQCTATI TG
ATCCAAGCAG
CATCGCCATT
ACAAACCCAA
GAACGATATT
AAGGAATAAG
CGCAGAAGTG
TAAAGCGGAA
AATCAAACCC
CGTCCAATCC
CTI'rGAAACG
CGCTAAGCAT
TATTAACCAT
TAATGGGAAT
TAAGGTCATT
GCAAAAAATA
GATTGCTTCC
AAATATCTrA
TAATACATT
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1140 1200 TTATI'CGCTA. CTGACGCCCC INFORMATION FOR SEQ ID NO:1240: SEQUENCE CHARACTERISTICS: LENGTH: 2151 base pairs TYPE: nucleic acid PCTUS 96/O92.c4 APNUS 180DEC 1996 86 STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii)- HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1 .2151 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1240
TATGCC'ITAA
TATCATGGGG
TTAATGCCCT
GGCTATGCGA
GGCTTTTGTA
AA.ATTTGGTT
GTTIGCACCCC
CCTAATAGCT
AGACAAAAAT
TGCTATTTCA
AGGCAT(3T1A
AAAGCTAAAG
TCTTITTTATG
AGCCCTTATT
CCACAAACTA
CAAGTGGCTG
CCTGAACCCC
AGTTGGGCAA
ATGTATGTCT
GAAGAATrAA
GAAAGCTCTA
AAGT'rGCCTT TrCATCACGC
TI'AAAAGGCG
ATTGTCTCTA
GGTCAATI'GG
GCCCAAGATA
GCTACCCCCT
GCTAATI'rGC
ACTACAGAGA
GGGGAAAAAG
CCACAAGAGC
ACCTTAGAMA
TTAAAAAAGC
CAACAAAGCG
AGTCGTTGAG I cAAGCATCT'T ?TGTGGCTAC C
GATGGGCTAA
AAGTGGTGCA
T~CCAAAGCT
CTGGTGCTGG
GTATTATCAC
TCTTAAACAA
ATCCTTTTGA
AAGCAGTAGG
AGCTTTTTGT
ATGTCTCTAT
ACAAGCAACT
ACGCCCCTAT
ACCAAAAATA
CTTATGGAAC
ACACTCCTGA
ATAAAGACCC
GAACGGGCAA.
CTTTAGTAAG
AACCTGAAGA
TCTTGTTAGA
AAGATTATGC
TGGTGCATTA
AGGAAGTGG
TCTI'TGGAGG
TrATGAATAT
TAAAACTCAA
CTATTGATTT
TTGAAACAAC
TAGAGAATGA
TTGAAMATTC
ATGCTAATGA
CACTGAGTGA
ATGA'AGAAMG
~CAGGCTI'AT MGATTTAAAA AT1TATATC L'GTrAAAGAT; rAGATITAGGGC LAGAAATGTG k.AAAACTGOCA FGATATrAAA
TAAAAGGATT
CGATGGTAT
cTTTTrGCT
:GCACCAGCT
TTPCCAACAC
2AAAAATCCC cATAGATATG
A.AAAGGGGCG
TGATGAA1T
AAAAGTGCGT
TATCAGTATT
AGCCT1TIA
GCGTATTTTIT
AATGCCAGCA
TATGATrAGA
TAACATTGTC
CGAATTTACA
TAGCTCT1TCT cAATrCAGAT
AGCTAATTAT
AGAAGTAGAG
CCCTAATCAA
GAGCA)LTGAG
AAACTTAAAA
AAATATAGAG
AATCAGTATG
cGAFACAAGAA .rcTTTTCTC AAAGCGTGI' TGTAGGGCTI' TGAAGTCT ATCITACTAT
GCTAATCTCT
ATTCCAA AAACCAcAGA AACTITCGCAT .TAGAATGCT TrAA ATTT TAGCAAAGAG ;TGCAATTTG ATAATGGCTT TATTCTAGGT MNCTATGACA AGCCC?1'AGG AACGATGATI' CGTGTGGCTT TGCCAAAT1' ATTGACTTTG ;GCGAACTAA GAGATAAGAC
CGCAGGTAT
kT=rAATC C71'ATGGTGA TGATAACACT ;T GAAAAGA TGACCTTTGC GGAGCAM'ITA TAGATG AAGAAGACCA TTGGGTATCT 'T1'TACAAG TAGTAACCAA
AGGGCATAGC
'.ATGATTATG CCCCCI'AAT
ACACCCTAAA
GATAAAAAGA CAGGCGAAGT TATCTTAGAC :AAGCTAATG TIrTAAAACT CITTIAAAT AATGATGAAA AAAACTATGA CCCAAGAGAA TTAGATGAGA TTATAAGGAC
AGATGCTAGG
GGGAGCATTA TGTCTI'C?1T TAAGCG'1?I'I GAAGCTACTI' CTAAAATGAG
CTTTGATTAT
TACATTGTAA TCGCTCAAAT
TGATATAGGC
GAGAGTATTG CTAAAAACCT
TATGGTCAAA
ATCATI'GCTG ATGAATI 'GT TAGATI'TGGT CT'I'rGTCGCT CTTATAATGT TGTCCCCTI!A AAATACTATA GCGATGATGA TrGAMAATC TTrAAGATGA ATAGTGCTGA AGATGCTGAG AGACGATCTA AAAATTATTC TACCGAAAAA TATAGCCATG AGGGTAGAAA CTACTCACA GAAGTcATG TTATTGTTAC AGOGGCTAAA TGGTTCAAAG ATAAAGAGCT TTTAAAAAGA AGACAAAGAG TTGAAGAGCC
TATACAACCC
AAcAAAGCT AcTDAGAAcc AAGTAATAAG AGAAACACTA ACGAGAATAA
TCCCACTACA
GAAAGCGAGA AAGACAATGA
AAGTCCCATT
CAAGGAAATC ACAATGAAAT
TGATGAGATT
GAAGAGAAMA GAGCCTTGTT
TAAGAAAATG
GTI!ACACAAA GCACCCAAAG T 120 180 240 300 360 420 480 540 600 660, 720 780 840 900 960 1020 1080 1140 1200 1260 1320 1380 1440 1500 1560 1620 1680 1740 1800 1860 1920 1980 2040 2100 2151 INFORMATION FOR SEQ ID NO:1241: SEQUENCE CHARACTERISTICS: LENGTH: 7320 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular Q(ii) MOLECULE TYPE: DNA (genomic) PCTius
APNUS
96/091? (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc..feature LOCATION .7320 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1241
TATAATCATC
CAAAATGGAA
CCGcAAGAAA
AGTGATGAAG
GGA.ACAAGAG
GAGCGAGATA
GCAAGAGCGA
AGCGAAGAAA
CCATCTCATC
GGACAGACTG
GACCATGAAA
AACGAAAATG
AGTGAGCGAT
AGCCGATTAC
AGGGATCAAG
AI'AGAAACA
CAAAACAACG
ACTAAAATCT
TTAGAAAATC
GTGCTGGATA
ACACAAGAGA
GCGCAAGAGC
ACACAAGAAC
ACGCAAGAAA
CTTAATCCTA
CGCTACAAGQ
ATCTTAAAAG
GGATGGGGCG
?I'AAACGCCT
TACTACACCC
AATA.ACGACA
GCTCATGCGC
GCTAATCTM'
TACCAA=c
ATCTATAGCI
AAAGCTATCI
ATGG.ATGCT)
GCGATAAGAC
GTG?1'T Th*
TATTATGACI
CGCI'ITGATJ
?1WTGGTIVTCJ
GGCTACAGCJ
AGCATCAATI
CTAGGGCA7
TACAAATACI
CAAGCGATA,
GACGTTCT
\CTAAAAGCC
CAAATAAG
AAGAGAGAAC
TTCACCGCAG
ATCTTTCACA
GAGIIrATCG
GAATACATCA
ATAGCA.ATGG
AGGGGGATAA
AACAAA.ATAG
GACGCTTIACG
ACCAAAGAAA
GAGACAAAAG
ATGGAATI'GC
ATCATGCAGG
AGGGAAGACT
ACACTATAGC
ATCCTTTAA.A
TTTATGACAA
GCCTTAAAAA
GTCAAGCCAT
GCAAAATAAC
AAACCACACA
AAACCACACA
ACGCGCCAAC
AAATAGAT1T cTAACATTAA
GCGAVITCTA
GGTrAGAGAG
TACTCACTAA
CTAAATTAGT
*ACCATCCAAA
CAAGCGATAA
CTAAATTCC2l ATCAAGAAT.2
CCAATGACA)
LAAGAATTGA)
L AAAACCCTAI
'TGCCTAATA(
kAAAAAGGCGJ k AGATACTCAJ k. GTTTTATTC( k. AACAACAAA1 k CGCAAGATTL
TCAACGAAC
4 r' TGAGTI~cG, 3 ACTI'GCAAG, 3 WAAATTGC
TTATTGATT
A GGAGGGAAT G GCATITTITr T ATTTTAAAA
CGTTGCTGAT
AAATCGCGCA
AAGCGAACCT
CCJAAGACCCT
ATCTAGCGAC
ACATGTATCT
AGCATCAAGT
TCCCAGCGAT
CTCCAGAGAT
CCTTTTGAT
AAGGAGCGAT
CCCTAGACAG
TCAAGGAAGC
ACTCAGCGCA
TTATCAAAT
GAGTGAGCCT
AGATAGCPLTI
AT'rCCAArrA
ATCCATTGAA
TGATI'IAAAC
AGACAATAGC
AGAACAAACC
AGAPLCAAACC
CACGATAAAA
TAAACCGAGC
AGCCATTGAG
CGCCACTI'rA
CTACTTTAAA
AGATGAATTC
TATI'GATAGC
AAAAATCTTI
,GAATTACCGC
T1%CCCTAAl CGATGCGT1"]
AGAATTGAGI
LAGATGATGG(
LAATGAGAGA1
CGTGTTAJ
rT%2AAAAAGCJ k TAGCTTGGA!
"TAGCGATCX
k~ ATTOCAACGI ,k TAAGATCAT' ,k AACCCTAAA k AAAAACCCG c TTAGAAGA C TAAAGACGT c AAGTAACGA T AGTCA.AGTG T AAAACCCAC Tr TAAAGACGC
TTAGAATTAG
GATGAGCCGA
AGAGGACAGC
AGTI'rATTTA
CAACAGGCAG
AGAGGAGATG
CCAGCAAGCC
GAGAGAGGAA
TTGGGGCTTT
CATGGACAGA
AATGAGCTrG
AATGGAAGCG
TCAAATCAAT
CAAAATGGAC
TT-AGATAATr GATrAGAT
GTGGGGCGC
AAAATCAGCC
ACAACGAACG
GCTATCTCTA
GTAGAGTTGA
ACACAAGAAC
ACACAAGAAC
CAAGAAACAC
GAAGAAGT1' cT=rAAAAG
AAAGAGCAAG
AAGGCTCAAC
AGAAGAGCTI
ATI'rATCAAG GAACCCAGT3
TTCATCGGC
cAAGTCATCC 7GTGGGCAATC
SAACQAGAGTJ
ATAGGAG0G, k CACATCGCJ k. GCAACAGGC( k ACCAATCAA r' GATaACAccI PL CTrAAGATLT
CTGOTATGAA
C AAAGACTTC T GAATACTTT C TATAGATIT T GAGAGCTTG C TATCAATAC A CGCTATCAA G GATAATCTI :T AAAATCAAC
AGCAACAGAA
ATGGAACTAG
AAGAGGGAAT
TTGAGTCTAG
TTTCAGAAGA
GAGTATCAGC
GAATGGAAAA
TACCACAGAC
CTCTCTCTAG
TGGGCTCAT
ATAGACGCAG
CAAATCAAGA
cAGTATrATT
TTAGAGACCT
TAGA.AAGC TI
CCAGGCTCTIT
AACTCCTTAA
CTAAAAAAO-T
AAACGCTAAA
ATAGCGTAGG
ATAACGCTCA
AAACCACACA
AAACCACACA
CAATI'ACGCC
TAATCAAGCG
AATTGCAAGC
AAATCCTAGC
ACCCTGAGGA
ATI'TGAGCGC
IGTI'TAGATC)
1TAGGCACAGC
LCAGAATTAGJ
AAAALCACCG,(
CTCCTrATO( k TI'CATAATI'J r' TTGTGGTGA( k AAAACGCCAI -V CTOAAGTTAl k GCTTCACTA a TZTI'GCCT G TCAATGCGG A AAATAGACA A TTGATAAAC A TCCACCACC G AAACAAATG G ATTI'ATCCC !C ATAPLGACTP ,G AAGTTCAA) ,1T ATTTCCAAC :T CTA.AAGTCC TrAGGAGAA
AGCAGGAATTI
GGAGCGATCG
AGAGCAGGGA
ATCCCATAGA
AAGAGCGGAT
TGGAGCAAGA
ACCGCAATCC
AGAACAGCCA
ATITCCCACA
TGATAAAGCA
GAGCGCAAGG
ACCTGCTCAA
TGAAGA4AAC GCTI'AACGqT
AGAAGCCATI'
AGACCCTACG
cTTAGAGATT
CGCATI'CA.AT
ATTAAATCCC
AGAACAAACC
AGAACAAACC
AGAGCAAGAC
AGCCATCCCC
AGCTAAAACT
CAAACAAGAG
GCAATI'TAGC
ArIWITAAAGAA
AAGAGACGCT
ATTAGTT
CAAATTTATC
ITCCTATTAGC
TrAGAAAAc 1CAATCATAAA k CTTI'AGGG
ITTCTTGGTTI'
2ClTrrI'AGGc 2GAGCGACAT1T h AGCTATGCCT T GCAAAACAAC T TGCAAACCAT C CGCTAACT''I T TGGAAAGAAT 'C TGAAAACATI' G CGAACAAATI' A AGCGCTTAAA ,c CCTTAAAACA LA GCTITATCAAA :T AGAACAAAAT :A AGATITCACGA ;C GGAATTAAAC 120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1140 1200 1260 1320 1380 1440 1500 1560 1620 1680 1740 1800 1860 1920 1980 2040 2100 2160 2220 2280 2340 2400 2460 2520 2580 2640 2700 2760 2820 2880 2940 3000 3060 TTGAATGAI' TAACGAGCC PcT/US 9 609122z I PE/Uit~ CCCTrAAGCT. CTGATTTAGA GCTAGAAAAC
AA(
GAA~TTTGTCA AGAAATITrGG CTATCTCAAT
GA(
rCATTTGTATG GCGCTAAAGT CT1'AGGA'LTA
GA
AGAAGCGCTA AAATG3CAAAA CATAGAACCA AG4 TTTTIrGAAA G.GACTTTAAA cccTAAAAAA
GAX
TTAAT GCAA GCATCAATCA AAAAGGGGGT
TIN
ACAACCCAAA GTTTAGAAAC CACGATTAAA
GX
GACCACAAGG ATAATIGGCGQ CTATATTA
GC
AGAAAACTCA AAGAAGTTAA AGAAGCCATC
AA
GTGAAAGATIT TAGAGCTGAT TATCCCTAAA
GA
ATCAACAGCC CTTGGATACC CACTCAGTAT
TT
AACCA'rrATIG AAAAGCA.ATA CGGCGATALA
AT
GAAGACATCA AAATAGAACA CCTAAGCGGT
GC
TT'AAACGAGC TTTATGGTAT CAGGCATAAA
GA
GAAAGCCTTT
1 TA.AATAAAGT cTTAAACAAC
A
GATCCTAATG ACCCTAAAAA AGAAPLTATTC
AT
AGACAAAAAG CAGAAGAATr GAAAGAAGCT
T
AGAAGAACCC ATITAGAGCA AATCTATAAT
GA
TATGATGGCT CGCAATTAGA ACTAGAGGGC
T
CAAAAGAACG CTATT AG AACCATCCAA
GA
GGAGCAGGCA AGACTTTGTG CGCTATAGCC
AG
GTGAATAAAA CGCTCATTGC CGTGCCTAAC
CA
TATAAG;GCTT ACCCTAACGC TAATGTGTTA G1 rGAAAGAGAAc TITrATTCAA TcAAATCGCT Al CACACCCATT TrGAATTATT GTCTAACCCT
A
GAGCTAGTGA ATGCTI2AAAA AAACTI T3AA AC AGAGAAACTA AAAAACCCAA TGAAAGAGCC
T
AAATACGATG Cr.AT=TAGA AAAACAAGGC
TC
GACAATTTGA 7MG~GATGA
AGCCCACTTA
GAAAAAATTG cAGGACTTGG TAACCAACAA
G
AAAACG.CGCT ACTIGCATCA AAACGATAAG
A
GCTAATTCCT TGAGTGAAAT GTATCACTrG
C~
GAAAGAGGGT TAGAATTCTT TGAT'GATTGG G4 TTI'GAPLTTAG ACACTTCCOC TCAAAGTTAT
A
GATGTGCAAG GCTTAAGCAC cATG-TATAGA
G
ATITTAAAGc ATAACCCCCA cTTTGTGCC-
A
GTGGTGAAAA GAAGCGAAGA
AGTGGCTCAAT
TATAATGAAG GCTCTATCAT TOATAGGATG
C
GGGCAAGACA ATATCCTTrC r GACCACAG TTGATT3ACC CTAACGCTAA
AGTAGAAAAA
AATATCTATG AGAATrATTT AGAAACTCAT
G
GGGCTATCCA CACCCAAAAC
CCATAGCCAA?
CACGMAACTG AAAATAAAAA
TCCCCTAGAT
AGTTATGATG, AAAAGGGCAA TCTTATCGCT
C
AAAGAGAA&Q AA=CAAAAG CGTCAATI'rAC GATOTTTATA GCAGTT
AAGGCATTTAC
GCTI'rCATCC ATGACGCTAA
AACCGAAGAQ
CGTC.GCGGAQ TCAGGGTAT
ATIGGGCA-T
CAAGAAAGAT TAGTGCTAT
GCATG-AATTA
CAAATGGAAG GGCGT=GAT
AAGGCAAGGC
?TTAGAATGA AAATCTATCG
TTACGCCACT
ATCATAGAAA CTAAATCTAA
ACGCATAGAG
AATGAAMTAG; AAGACTI'TAA
TATGGGTAGC
ACAGGCAATC CCTTGATTAT
TGAAGAAGTC
TCAAAATACA AAGCCTTCAA
TAAAGAGCAT
GCTTCTAAAT TGGATrATCT
AMAACAGGAA
GTAATAATCC CCACTCATAC
AGAGATCAAG
GATTATGAGC TTATCAAAGT
TAAAGAGGTA
GAAGAATTAA CGCACAAGAA ACTCAAAGAA GAAAAGCTAG ACGCTATTAA
AAAGCAATT
GAAGAAGAlAG ATTATAAGCT
TTTAGAATAC
AAGTATCAAG TGGAGTTTAG TTrAACCCT jAGCAATATGG ?ITATAkkAA
CGATACTATC
GAGATCAAGT T G.ATGGGTT
TTTAAAA.AGG
AAAATCAAGG AlLTIAGAAAA CTCCATTGAA ~AGGGCTAL AA( JAATAAAA AT kLAAAGACT TIN .CAAGCTc AA, PCTTATTA TC.
GAcTGc AT ACTI I AG AG rAAcGATIT TcAAGGCG TG rrAAAG CC AGAAGAGT T GAcAGATI' AC TTATGAAG
T
CAAGCCGC A GGATI'TGA C CACTGATG
AA
TAAAGACT GG ,CACTrICA
AC
TAACTACC A ,CAGGGcGG TG CTGCATGG Al ,TI'rAACCA AC !TGTTGATA G( CAAcAATT Al ,AGGAATCA T GCAAGAAT
T
rrTAAAAACA A( :.TCATATTG A L'CAAAAATC
T
;CTCTAATC GI k~AATCATGTT AACGCTATrT
C.TAAGACTTA
AAATGGTTAA
cTTrTGcCG A
AAGTGTATG
TCATTGGAG
AAAAATGCGA
,ACGCTAGAA
,AATTCTA
ccACTAAAGC
AAGTCAGTT
LAAGCTCAAG
.CTAGCAAGA
;ATGAAGAGA
'TCCAAATGG
:AAAAGCAQG
:CTGCTAAAA
"ATTGCCCAT
GAAAAGACTT
cAATI'rAGAA
TCTAATGCGA
AAATTGAGAG
TAcTTCAATG
TTGAAAGATT
CTCTATGATT
GAGCCTTrAA
CAAAACAAGC
GcAAGcALT
AAGGGCTI'T
AAAGACAATC
AAcATGTTTA
TTGGATAACG
ATCACGAAAA
CTCAATCT TGTI'TATGAT :GTAAGGA
CATCAGACAA
3AAAAAGA
AATAACCCCT
~CCAAAAA AGCTCAAATC PLCTAACGC
TAAAGACGCA
~CATTAG GGATCATTC CAAAAACT
TATCTATAAA
?TGAGCGG CAACGTGAAA GAGGAT AG-AGGCTAAT ACTGAAAT CATGGCTAAT TrAATGGA ATrGAGCGCT CAACTAAG
CAATCTCAAA
'TTrTAG
AAACAATGAA
TCTTATAA AGTGCCTT GTrAAATA
CGCCCAAGTI!
GAGCAAAG
CAATCTCG-CC
~ATTTATAA
AGATTATTCA
:AACTI'TGT TTrAAAAACC ',ATCAGCTT
GCGCCCCCAC
;TGTITAGA CCATCAGGTr CAAA.AACG CATGGGATTA ;AATrGGG CGATGAAT1T :AAGGACAC
CACTGAAAAA
GACGCTGT GGTTATCGCG kGAAG3AATr
GAAAGAAGAA
k.GCTrATAA AAATAACCCT ~TTGGATAA AATCCGTGCT rjTrAGTCA AATGGGGATT kGccTTI .A AACTTCTATG CGCTAGAGA TTrrGTTTATT =TTAACCGG CACGCCTATA AACCCCTGA TGTGTTAAAA TGG=GAAGT
GGTGAATGAT
TCGCTTTTC
TAAATITAGC
,TATTGTCTC TAATGATGAT GGATAAACC
TATCAATGTG
r3GCTI'TAGA
AAATGGAAAA
,GGc;CAAGAA
AAGCCAAAAA
hAGTGGCTI'r
GGATTACCGC
LAAGCTATGC
TATGG.CAAAA
;CACACAACT TGGITTCATA AGAAGCGCT AGATAACGCT LtACTTAGA AAGCTTGTCT kAGAATI!AGA GAACGAGCTC rAGCTAAAGG CTGTrCGTIT GTATCCCACA
AAATGAAATC
AT'T'TrA A JIGCTCAAT TGGGCGTAGG
CACTAATGTG
GGAGACCTGA TGAATIGTr4_ ACCAAAATGA
TCCTGAAAAC
AcGATAGCCG TATGTGGCAA ACGCGCACAA ATTAGGCTTG G;CGAr.ATGAA
AGCAGAAGCG
3120 3180 3240 3300 3360 3420 3480 3540 3600 3660 3720 3780 3840 3900 3960 4020 4080 4140 4200 4260 4320 4380 4440 4500 4560 4620 4680 4740 4800 4860 4920 4980 5040 5100 5160 5220 5280 5340 5400 5460 5520 5580 5640 5700 5760 5820 5880 5940 6000 6060 6120 6180 6240 6300 6360 6420 6480 6540 6600 6660 6720 6780 6840 6900 6960
AAGAAAGCTT
TAGAAACGCT
TrAAAAATGA
AAGAAAACGC
AAATAGCCGA
TGAACACCTT
TGGTGAATGC
CCAATATTGC
GCTCTTATAA
CTATCACTAA
AAAATATCGC
A)AAAACAAC
TCAMAGATCC
AGAAAGTAAG
CTCTATGAGT
ACAAAATAAA
GTTTGTGAAT
TTATAAAACT
CTATAGCCCT
ITTCTGCGCT
ACTCCCTGAA
TAAATACACA
PUT/US 96/09122 IPEMS lb DEC 1996
AGATTAGTGG
GATCATAAAA
GCGTTCAACC
TrAGAGAATG
GAGCCAGCTA
AATGT IGAT
AGCAAAAACC
CTCTAATAGA
CTAAATCTAA
AGAGGGAAGA
CAGAAcAAGT
ACTACGAGA
TTCTTACCCA
TGAITrTAGCT
AGAAGTCT'A
GCAAGGGGTr
GATT'GAAAAA
CGAACAAGAA
CGACTACAAT
AAAATCGAGCA
AAGAATTTGA
AAGGGGAACA
GAAATAGAA
GTGGAAATTA
ACCTGCAAGC
AAGACAGAA
ACGCTGAAAA
cAAAGAGTCA
AAGGAGATGA
CTA.AATCAAT
TTTAATGG3 7flATAAGCCT .A kGAGCGAGT TGATGAAkATA
AATCGCTAAT
GGGTAGAAGA
7020 7080 7140 7200 7260 7320 INFORMATION FOR SEQ ID No:124 2 SEQUENCE
CHARACTERISTICS:
LENGTH: 1275 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION I1.. .1275 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1242
AGGGAGGGGG
AAAGTAGCCA
AACACAATTA
ATGTTTGAGT
AATTGGGGGA
CCATcTGAAA
ACTAACACTA
TATGcAATGA
CTCACAATGA
'rrAGGCTTAT 1TAGGT1I'AA TATcTI'AAAA TT'rAATTATG CAAGGCT1'1 GcAATGTCT TTAACCA'rrA Trr 7ATCAATA AAkAA?~GCA
CAAGTTAAGC
CAAAGCTG
CGATGAATT1' TTrGACACC
C
AAAGTCTTGC
TGAACATGTGC
TTAcTATTT
ATTTATG.ATA
TTAAAACCGC
TATGGGTGTG
TrAAAAATCC TAATG.ATIr AACTAGCCAT
ACTTATCGCT
ATTTAAGTCC
TAGTGAAAT?
TAGTTAATCT GT GGG ATAAT TACCTAAMAT AArATGT TGCTTATTAT
TGTGTTATTA
TTGTATrGCC
TTTAGGTTTA
AGCTCAT17rC CCTTACTCTr GAATAATCTA
TAAAGTCAAT
ATGGCAATGC
GGATAAAATG
TAAAAGGAGA
TTGGAACTCT
TIGTTI'TAGG TTCTGT3ATT ATATCTI'TGG
CACAAGTGGA
TGACAATAGG
CGGAGCTGTA
AAGCCTATCA
GAGTGCTWG
GGCTTGGAGC
AATCAGTGGA
GGGTGAAACA
CTTTGTAGCA
:?rATGGGTA ;GTAGC LTLrr rGGGTATA ;TrGTATTA' kACACTI'ATT
:AAAGCCTAA
TrAGCATAG GCVTrTGATG TITrrrAGGA
GTTACAGCAG
ATCCCCCAAA
TATAAACCfl
ACTTTAATCC
GCAAATGAGG
TATATAGCCC
TTTrCTTTC
GGCGTGGGG
T1'TGGGGGTA
GCGACTAG
GGGGCAAGTG
AGTG LrAAA.A O'GTTrGTTrGA C E'TcATGCACA
I.GCGTGTGAA
rAGCGTTTGT rTATCAATAC PTGATGGCr
GAAATTTAGC
GTATTAACAT
TTTTVAGGGGA
AAATrI'rTAT
CCAAAGGCAT
GTATGATGTT
cCACTAAACA
GAAAATTAT
ATAGTT1CTAT
TAGTCAAACG
CAGTAACAGA
GTCGCAGTrAT
CAGGACTTCA
CTATGGCAAA
GTCGCTTGG
;ccATCTCAA kCTCATTITA kGAGGGCGAT k.GGATTATC 3,ATATTCTAC
PGAAATCCCC
CTCAAGTGCG
GTrTTAATTGG, ATTATrIGVT
GTGGTCAGCA
GTrATTTAGC AGTAGCT'I'Tr
CGAAGTCACA
TGATGTCTI'r TGTAGGCT1'T
AGTGCCTGAT
AATGATGCAA
GG'I GCTAAT
AGCTGGAGCT
CCACAGGAGT
ATI GATAAT 120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1140 1200 1260 1275 GATAAAAATA
ATAAA
INFORMATION FOR SEQ ID NO:1243: SEQUENCE
CHARACTERISTICS:
LENGTH: 1326 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) 11 IN I PCT/IS 96/0912.2 It'EAAJ 16 DEC 1996 (iii) HYPOTH{ETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE- NAME/KEY: misc..feature LOCATION .1326 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:12 43
AAGGAGCAAC
CCG.AA1-r AT
TCAGACAAGG
AAAGCAAGCA
CGAGTCTATA
GAAAGTTCTC
TACGATCTGA
ATTCTAACCC
ACCCACCATA
TACGACCATC
AGAGAAATAA
FrrGAATCAA
AAACTAGAAT
TCAGCAACAA
ATGCATAGGC
AATAAGATTA
CAAAGCGCTA
GAAATCGCTC
GATGGGAATA
GAAAAAGCTI'
GCTAAAGAGG
AATACAATAG
CAAATT
kAATGGCTTA CAAACCTAAC TVGCATCT
AGATAAGGGC
.CcAATAAAAT
ACAAGAGCCA
rGATTTCTAG
AGATCCTAT
AGGATAATAG
TAAAGAAGAT
GTGTTrATGA
AGCGAATAAA
TTGATAGAAA
TATTGATAGA
A.CACAAACAG
CTI'AAAAGAA
ATGAAACGCA
TAAGAAAGCC
TrAAAGATAT TrACCAAGAA TCCCCAGTAT
TTCTAGCGCT
TAAACAATGA
AAATACCAAA
TTGAATTAGC
TAAAGAAGTG
ATTATTATTC 'rrGGATAGAT TIATCAATGA
AAATAAACTC
AGCAATTr CTTrAATAAT TACAAGAAAA
CAGAGATTAT
AAGCAAAAAT
TGAATTGCAA
AAAGAGAAAT
CAAGCCTTTT
ATAAGGAGCG
TTATGACAAA
GTGGTAATGA
GCGACAAAAT
AGACTAATAC T'rCTAACAAT
A.AAAAGAAGT
GATGTITGCAA
:TCCCTTATG
GAATGGGCAA
GTCAATTTCT
GAAGGGT'ITG
AATAGAGAAT
TTGAAAGAGC
TITAGAAAATG
GTAGAAAGAA
GAGTA'TTTCA
CTGAATACTA
CATATITTAA
AAAGATGATA
AAAGAAAACC
GGTTCTATTT
TC TTTAAGAA
AAATACTATG
AAAGAAATTT
TTGGTAAGCT
TCTAGTGCAA
ATTATTCAAM
TAAAAGAAT'
CAAACAATCC
TCGTGAAAAC
AGTATI AAG4
TTGCCAATGG
AAAGGCGCAT
T'I=ATAAA
AAGGGTTAGA
GCAATGAAAT
CAAAPLGATGG
AGC TTTACAA ACGAcAATGA
TCCTAGAGCA
ATGCGAATT'r
ATCTCAGCGC
TAGGCTGGAC
GCGCTCTTT
AAAGCGTTTA
TAAGAGACAC
TGAGTGCAGC
ATAACAATAA
ATAATGATAA
kIAGAGAGCAA rGTTGAAGAG
GCA.AATCAAT
C'rGAAAAA
TGAGATAAAA
cACTAAAAGA AGAAAi GAA
AATCCAATT-G
CGTrTAAAGAA
TGGATTGGTA
CAAACTGCCT
AGAAGTrAAA
ACAATTGCTT
TGCTGGA
CAATAACGCT
TAAA&GAAGAA
AAGTTTAGAA
TGTrAATGGT CAACAATrT
AATCATI'CAA
CCCTATTAAA
TATAATCATC
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1140 1200 1260 1320 1326 INFORMATION FOR SEQ 10 NO:1244: Wi SEQUENCE
CHARACTERISTICS:
LENGTH: 210 bass pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (geriomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc..feature LOCATION .210 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:124 4 ATCAAACATI' ACAAACAATA TGGCACAGGC TTACATCTAT ?TAGGCATAG rMrCAACA \\TCTTATC AAGAAACCCA AGACTAGTT TTAACTTCAA GGGCGTTAGG
GCATAGCTCC
U)JIACTCTCTA CTAAGATI'A TATTCATACC ACACAAGAGC ATAACAAGAA
AGTGGCTCTT
TGa ;t GATA GTTTGATAGA
GAACAAGAAG
120 180 210 tN)A 2 6NEV49 891.
INFORMATION FOR SEQ ID NO:l245: Wi SEQUENCE CHARACTERISTICS: LENGTH: 447 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc-feature LOCATION .447 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1245
AAAAAGAGAA
GAGCATACAA
GAAGAACAAG
CCTAAAAAAA
ATTGCCTTI'A
'TrTAAAGAGA
AAAAACACCC
GGCAATAATG
AATACATGCG
GTATGGAT
CCCAAGATAC
GGGGGCGTAA
GTCCTI'GTGT
CACGAAGCAC
AAGAGCAAAA
AAAACAATGA
TTTAGAAGA
ACAACAAAT!
CCCCCTAAAA
AAPLAAGCTTG
GATAAAAGAA
TT-TTATITGAA
GCTTTIVAAAG
ACT T3AA
GTTAAAAAGC
GATGAGCTAG
CAAGAGCCTA
TTAGATGAAG
CTTAATGAAT
GAAGCGCTI'A
CAACTAGAAA.
ACAAAAATAA
AAAAGAAGTT
GCACAAAGGA
ATAAGAAAAA
TTITGCTAGA
TTAGGCATITr
GATTACAAAA
ACACAATAAG
TGAAGAACAA
AGTAAAAATC
GAGCTI'TAAC
ATTITGGCTCA
AAAACACAGA
CAAAGAAAAG
120 180 240- 300 360 420 447 INFORMATION FOR SEQ ID NO:1246: SEQUENCE CHARACTERISTICS: LENGTH: 1119 base pairs TYPE: nucleic acid sTRANDEDNEss: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii.) HYPOTHETICAL: NO (iv) ANI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .1119 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1246
CTTAATACTG
GTTATAATGA
AAAGGTTTGA
GCTCCCTTAA
CACAATATCA
\\TGAATAGTIG
)AATGCGTAG
ATAAAATAAC
TAAGTGAGAT
ATAAAACTTI'
TGGCAAAGCC
AAGAAGATAC
GTTGGAATT
AAGAAGAAAA
TAAATACTTG
TATT1AAGTTT
AAAAACAAGC
ITTATTAAGC
GCTGACTAGC
ATCTAAAGAA
ACATAAACAA
ATTAI!ATTG
CAATTAAAAG
TTATTAGCTG
GATGAAGACT
TGTAATGCTA
TTTCCGCA.AG
GCCCI'AAT1' ATATATTr
GAATAAAAAT
GGGTr1'TACT
TATTGAAACG
AGGTGGACGG
AATATAGAGA
TAATCAATAA
AA).ACTTTAT
GATITAGATA
AGGTGCTACT
AGTAAAACTA
CTCTCAATAC
AAAGATTTT
AGAAGACACT
120 180 240 300 360 420 ROT/US '96/09122.
IENS 10 DEC 1996 AAAGATAAAG -AAGAACTTGC AGGCAAAAAT T1'ATGGCT CAAC E'ICAAA CCATGCTTGA TGGCACGAAC GCTTG GGGG GATATAGTG ATGAAGGAAA AAAAAAGATI TTGAAGAAAG ATGAGTGGCG
AAAACGATA
TCAAATAATA 'ITAAACCCTI' AATATCAAAA AAGAATATGT ATI'CATAAAG ATTrGGGGATT ATTTGGGAAT
GTATTAAGAA
ATAGTTT1GGA AAAAAAATAC
AAAAAAAATC
TGA).ATGA.A
GAACGC'iTiT
TATAAGTAGA
GATATTAGCC
CACTTATGAT
TAAAAI'ACT
AATGTCAAAC
TATGGGCT'GT
TITTrGGTAAG,
TAAAGTAAAG
TTATI'CTATC
AA)LGAAAT'IA
GAACACTCTA
GATAATGGAG
GAGAATACTT
'TrTGGCGAAA
ACTAGACAAA
TGGTTAAAAC
ACAGAG ITGT
A.ATATGGAAA
GCAAAAGTCC
TCCTATGACA
TCTCATCAC
AAGAAAAAGC
AAGAATI'CCC
CTGAAGTT
ATAAAGCACT
GAAGTTATAT
CCTI'ATCTGC
CCAAATATCA
TAAATATIGAT
TAGATGGTC
CAGAAACTT G
ACACTACCGC
TAAAGTTA
AAATAAAAAG
TATIGATGAT
TGGCATTAAA
TAGACAATAT
TATGGCTAAT
GCTCCATAGT
AGAGCTAACC
TAAATATCCC
GAGAAATAAG
TGAAATAGGA
480 540 600 660 720 780 840 900 960 1020 1080 1119 INFORMATION FOR SEQ ID NO:1247: SEQUENCE CHARACTERISTICS: LENGTH: 693 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc...feature LOCATION 1 .693 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1247 AAAGAT1TACA
ACGCATAAGA
ATCAGCCAAG
TI'TGCTAAGA
TTTAGTCCTA
GAATATGAAG
TATCTAT'1'1
GAAATCTATG
TATGACATTG
rG-AGTTATA ATCAGCT1'A
TTTAAAQ
AAACAAAGAA
TAATCTATAA
CTAGT'ITGT
TAAGCAATGA
TIGAT1TATGA
ATGATTTAGA
TAAATGGTAT
ATGAGTGCTT
ACTI'ATTCA
AACCTATAAA
GAAAAGACTA
AGA
t
'TITAGA
AAGGGCAATA ATGAAAACAA AGACACCCCT TrAAAGTrA
AGAGAAGTI'A
GAATGCCCCT
AAGCACTA1'1
ATWGCTAAAT
TAAAGAAAGT
AATAGAAATC
AGTI'TTAGTA
AGAAATCAAA
TGACAAAGAA
GAGCAAGGGT
ATCTTAGCTA
AMAATrCTA
CCTAGTGATTL
GAAGAAAAAG
GATGTAGAAG
GCTCAAAATG
AAAGGTTATG
GACmTAAAG
AAAGAGCCAT
ATT
TGAACTTGAA
AGGATACACT
ATATCTTAGC
?l'TCACGCTT TrAAGCCTAT
AAGATAGGCT
AAGTGTI'rAA
TCCTTAAAGA.
CTAAAGAGAT
ACAAAGACAC
TTTCTAAAAA
TGAATrTTT
AGAACAAGAA
CAATATGGTG
GATGT GTAAG AOATG3AAGAA
CTTTAATTAC
TIGAAAGTG3TA TAAAT1'ITCT
TAGAGAATTT
CGCACTTT
ATTGCAACAA
120 180 240 300 360 420 480 540 600 660 693 INFORMATION FOR SEQ ID NO:1248: SEQUENCE CHARACTERISTICS: LENGTH: 1263 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO PCT/iS 9 6/ 09122a IPENUS 1uoDEC 1996 893 (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .1263 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1248
ATGAMGGTT
TTTGCAGAGG
ACTATCATAG
CAAGCTCAAG
AT 'AGTAGTA
CAAATAGAGA
GCACAAAATT
GCTCTTACTA
GGCGAACAAA
GGCTATGGAA
TTGTGTAAAA
AATAACCCAG
AATAAGCAGT
GAG71'TGGTG
GAAAATAAAG
GATAACGAAT
AAAGACGCTC
AAATATTrAA
AGCGAGATI'A
AACCATATAG
TACTTTCAAA
GAT
TAACAATGAA
GGGAAACTCC
GCAAAATGGT
TCAATCAGT
GTGCTATCAC
GCATTAGATA
TGTTAAGAAA
ACAATAAGAT
CCCAAACCGC
ACATGCAATC
TGGTAAACGA
AAGAGCAAAA
TAAAAGATAA
TAACTI3ACCC
AGACAGGTAA
TAGAACAAGA,
AAAGCCAAGC
AAGAAATTAC
TGACAGATGA
ACAAACAATTI
ACCCTAATGT
AAAATAGT
TTTGATTGTC
AGATAGTATC
ACAAAAAGTC
'rrrAGCCAAT
CAACTATGAG
CAAATACI'A
TGTCAATCTr
AAGAGATGTG
ACI'GCTGGG
TAGTAATI'AT
ACGAAGAT
ACTGACCCA
TACAGCTAAC
ATGCGACCCT
AATCCAAACG
CTACGCAAAT
CAATCAAATG
TTATITAGG
AACGCAAAAA
TAAATTTGAC
TrTAGC!ATC
AATGACCCAG
AAAAGATACG
AATAACATGA
CCTATGCAAG
AATI'TAAAGC
CAGCAACAAT
AAAGATCTCA
CAAAATCTCA
GAATTGAGTG
GAAAGCGAGC
TTGCTTAGAG
TTTCTAAAAA
CATAATAAGC
ATTAAAAATG
CTCACACTTG
TrCAATCAAA
CTCTTTTTAA
CAAAATAATG
AGAATAAACG
CAATTTGGCT
?TTATGWIG
AAACCCATG3T AAGAGA'PrAT
TAAATACGAC
TTTTACAAAA
AAAGCATAGA
GCCCI GGCT
ATAACCTAAT
TTCAGTCCAT
GTAGAGCGTG
AAGCTCTTI'
TAAAGAAAA
GACTTGATGT
AAGGGATACA
TAITTAGGAC
ATTTAACCAA
GGATTAAAT1'
ATCAAACAAT
ATGGC'TrGG
AAAGAGAAAG
TTCCCA'TT
TAAAAGCGTG
AAGTCAAGCC
T1'CTAAGGCT
TAATTCTG
CGCTCAGTAT
AAATTGGAAC
TAATGTCAAT
CACCAAAAAT
TAGTGGCAGT
GGGGGAAATG
AGCAACAGGC
GGTrAATGAT
CCTACAAACT
TTATTGCACA
AACTCGCTTA
AGCCTCCAAT
ACTrACTCTA
GGCAATGCAA.
GGAAAAAGAA
AGCTAGAATA
TAGTATATGG
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1140 1200~ 1260 1263 INFORMATION FOR SEQ ID NO:1249: Ci) SEQUENCE CHARACTERISTICS: LENGTH: 1338 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Hlicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .1338 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1249
AAGCGI'GGT
CCTAACGAGA
TATITTGACT
TT1ACTGCCTT
ATGCTTTTAA
TGCGTCTI'GA
GGGGTGTGTA
TTAAAGCGTG
GGCTTGTGTG
GGTATTTCGT
ACCTTrAGA GGGGGGCTrC
AI'ATGCGAA
AAGAATGCCA
GCGCGGGGTA
TCCCTTCAAA
TGA'ITGTAGG
AAGTGGTGCG
GCGAGCG Tr
TCAAGI!AAG
AGGTTTGGCG
CGCTCAI'CT
AGAAAAGTTIA
TCGGGCGAGT
AACGAAGAAA
GCCTTATGAG
TATCCCTI'TA
TTAAACAGGA
TCTAGCATTA
AGTGCTTTAG
GTCGCTTCTA
AAGCGTTCI'
TCAGCGATITA
AA'TrAGAGC
CATCATTCTA
AATGAACATG
GTITTGCTCC
TrrrAAAAAA
TGGAAAAGCG
AACATGCGAT
TAAATTTGAG
AGAAATCA
CGTATGAA
ATGAAGI!AG
GTTTAI7GGA CT1'ACTCAAC
AGGGGTGTCT
CGTGAAATCC
TTTAATGGGC
TGCTAATCAT
AGAAATTrA
AGATATGGCT
CTGGCGTGAA
TTAGAAATT
120 180 240 300 360 420 480 540 PO/US 9 1l92 IPEAAJS 18 DEC 1996
TTAGAGCAAA
GTAACGGGAA
AT 'VFAGCT
CAAACCGGTT
GGCATFI'CTA
AAAATACG
TT TGGCACGC
GAATGCGGTT
GCcTTAAAAO
GTAGTGGCTI'
GA.ATACGCTA
?I'GAATC'1'IA
AGTTTGCACT
GCGGTGAAAA
CI=AAA.AAA
!TTTACGCC
TGGATTTAGC
TTTIATGCGCC
AAGATITCAT
CTAATCGCAC
CAGGATTGT
TGGAI'IAT
ACTTGCCCGC
TTAATATTGG
TTGAGACCCG
ACGCTCAAAA
TCACGCATIC
AArI'GCGT
AACCCCTAAC
'ITTAAAAGAA
GAATTTI'AGC
TCATAAGCTT
TGACACGCAA
ACGGCATGAA
GCAATITAC
ccATAAGAAA
TATTAATATI'
AGGGATI'TCG
GGCGGGTTGC
GTCAAGCGAT
CATAAACGAT
AccTCI'GT
GTI'ICATCAT
GCGCATGCTA
TTAGGGGGCG
ATCCCTCCGA
T11'ATI'GATIG
AGGAGCGCTC
GAAAACAACC
TATGGGAATTI
CCCTATGArrr
TCTTGCGCGG
TI'TAACGCTA
ATI'rGATTAT'r
CTGTGAGCC
TGTGTAAGGA
ACCCTAAAGA
T'rGGAGGGTG
GT=TAGCGC
AATTGCCITrT
TAGCGTATCA
?TTAAGGGT
TAACGGCGAG
TAGCGAGGGT
GGCCTTATG
AACCCGGATG
TGCTAGACAG
GGCI'CTAAT
ATATAGGGCT
TTGCGAATAC
CGGTCTTA
AGGGGGCGTG
AAGAGAAGAA
ATTAAGAGAT
GC 'IGTGTAT
TCGTGTGGG
Tr'rAAGCTAT
GCATGATITG
GCTI'AGAGTG
C1TrGAAAAAA 600 660 720 780 840 900 960 1020 1080 1140 1200 1260 1320 1338 INFORMATION FOR SEQ ID NO:1250: Wi SEQUENCE CHARACTERISTICS: LENGTH: 1290 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .1290 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1250
TATOTGATAG
TT'rAGCCTGC
TTAAGCTCTT
TCT ?ITAAAA
AATTCTGGCA
GTT1'TAAGCG
AAGGCGTTQ
GTAGGGGGTC
AGCGCTTA
CTTAGCC6TA GACGGCGT1T
GCCAATGATC
CGCCTTCTT1'
AAAAAAATGG
GATATTTIACA
CTTATTGATG
GTGAGAAACG
AXTCAAAG
TTAGGAGATG
AGT'ITCAATG
GAAATTGATA
CTATTCAAAA
AGCTTGACAT
TCGCTCAAAA
TAGAAATCGC
TCACACCCCC
CTAGCATGCG
GGGACAATC
GGGCAAAGAT
CTTTAAAAGC
T'rrAAGCGC
ACCACACAGA
TAAAAATTTC
CGTCTAQCGC
TAAAAAATGT
GCGCTCATAT
TAGAGCATGC
AAATCCCCGC
CTAAAGATI'I
CTI'TAGGGAT
CGAGTCAAT
ATCACAGGAT
ATTTAGAATG
AAAGGAGTCT
TAACGCCAGC
ACCTTGTI'TC
TCAAAAT'A
AACAACTATA
TTrATACAGC
CCTM.ACGCA
TI'TAGGGAGA
TGGATI'AT
CTTACAAGCT
AATCATGCT
ACCCCTAGAA
GTrI'Tr='A
CTGCTCAAC
AGAATATOGTT
CCCTI'1AAAA
TTTAAGCATC
ACGAGCCAAA
TGAGTGCGAA
AAAGCAGCAT
TGCGATGAGIr
CGCGAACAI
CAATGG:AAAI
GATAAATCGC
GTGCGGAATT
GGGGCTAAAG
AAAGAGCCTA
GGGCTrTAA
CGCCCCATGA
GAGGATAACC
GAAAGCCCTA
CAAGGCATAA
AAAAG??QG
AAACCCCTAG
GCTCTCGCTT
CCCACTCGCA
ATCCAATCCA
GCGATCAGTA
GCTATGCTT
GAAAGCGATA
GAATIGAAG
?ICTAAGA
erTCGCTGITT
TCTTTCCCAA
TCTCGCACAG
T
T
TT'AATOGG
TGGAiAAATAC
ATAAGATT
GCGCTCAAAA
AAAGAATCAT
ATTTTGCCCC
TCGCTI'CAGC
GCGCCTATAA
GGGCTAACAT
AATCC'rrrGA
GCGCGATTAC
TAGMAGCTT
AAGAT~rAGA
TTGATCAGAA
TTWGCAAAAGG
GGATTAAAGC
ACGC4='IA
TTAAACCCCC
TAACTTTAGC
*CCTTCAGCT
AGCCGTTATT
AGAAGATGT
CGCCAAAPLAT
AAXITrGCAAC AGGCC T1'
TGAGCCTTA
CTTAGCGATT
TCAAGTCAAA
AGAAAGCGAG
TCAAAATCAA
CTI'rACCATA
QCCAAAMAGC
TGAGGTTG
AGTTATTCGC
TATCGCCAGC
CAAAAGCATG
GGTTGT'rrCT
TATAGAGGGA,
TATTATCAAG
GTI GCCTTTA
TTGGCTCAAT
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1140 1200 1260 1290 2) INFORMATION FOR SEQ ID NO:1251: PO/U 9 6/ 0912 RPEAMS 18 DEC 1996 895 Ci) SEQUENCE CHARACTERISTICS: LENGTH: 576 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-.fieature LOCATION .576 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1251
AATGCGCGAA
GTCTCAATGG
ATACAAATCG
AAAGAAATCA
ATCCCTAAAA
TACTTGAAAA
CAGCAAA'ITG
AACCACCCTG
TCGTTAGAAG
ACCAAGCAAA
CATTTCTTTC
AAATTAAAAT
CTGAAAAAAA
ATCGTTTGGA
ATAAGAGCGT
ATAAGGGGGT
TGGAATCCAT
AAGTCAAGGG
AATTGCAAGA
CCCCAAAACT
CCAACCTTTC
GGCTAAGGAT
TCAAAACAGC
AA~ATTC
GATCATAAGA
TAAAATCACT
GAGTAAAGAA
CGTGATCAGC
AAAAAAATTG
CTTGCAAATC
AGCTTGGCT
TATGGTTTT1
TTGATTTITG
AATGTGAAAA
ACCCATGGCA
GACGCGACTT
GGGTATCAAA
TATCCCACTA
CAACGGAAAG
GCTTCT
CAATCTATTC
G'1 1TGGCGT
GCTCGCTCAT
TI'GAAGAAGA
TCCTAA.ACA
GCCCGTATGT
TC(TGCTTT
ACCAGGCTTT
TGGCTTTAGT
AAAAAAAGGA.
CAAAAGAGCG
TCATAACGCT
TCCTAAAAAA
GGATTTAGAA
GATCAAACCT
TGGGGAC ATT
AGTCGTCAAT
CTCTCAAACC
120 180 240 300 360 420 480k~ 540 576 INFORMATION FOR SEQ ID NO:1252: Ci) SEQUENCE CHARACTERISTICS: LENGTH: 261 base pairs TYPE: nucleic acid STRANDEDNESS: double CD) TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1 .261 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1252
AAATTACCAA
ATI'AACGATA
TTAATGGGCG
AGTAAGAT'G
GAAGTGAACG
TCCACGCATr CGTTTT'AATG TGITTAGCGA TCCCCTCTAA ATGTGGCACT CI!AGAGACT T GGGCGTTC AAAGAGAAGC AGTCCGTTAA AGTGGGCGAT TATGTGCTAC TACACATCGG ATGAAAAAGA AGCCCTAGAA TCCATTGAGC ?TTACCAAGA AAACGCATGA A
AGTCATAGCC
GAGCTTGGAT
CTATGTGATG
AATGATCGCC
INFORMATION FOR SEQ ID NO:1253: PCIus 96 0912.2 1PEAN1S 1b DEC 1996 896 SE.QUENCE CHARACTERISTICS: LENGTH: 738 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .738 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1253 AAAGGAACAA GCATGAGCGA AAAAAAGACA TCAAAATCGT ATGAAAGAGC GCTACCTI'AA AGCGGTAAAA CCACGATGT1 GTAGAGGGCG ATrrGCAAAC GCGCATCAGA TCACCACCGG ?TTTGATTI'AT TAAAAGATGA GTGGGGAATC TGGT 1'GCCC CTCTCTGTCC CAGAGGGCGA GATGCGGTCA ?1'ATCAGTAA GTCAAAGAAG ACATGCAAAA GACCCTAAAA GCTTGGAAGA CAATCCACGC ATTCGTT
ACAACGAAAA
GGAAAAGATT
AGAAGGGTCT
AGAAAATCTA
CAACAGGGAT
CGAAGCGTGC
GGGAGCGTrA
CTCAAGCTAT
TGATAAGGTG
GGCGGACATG
ATTAAAGCCT
?TTAAAAAT
GAATCGTI!AC
TTGAGCAAGA
GTATGTCTGA
GCGGATITTTA
GCGGACAGGT
CATI GGAAG
GAAAAAAGCG
AATCTAGGGG
CTAAAATACC
ATTGAAGTGT
GAAGCGCCCA
TTCCTIAG
AAAATAACCC
ACGACATTAA
ATI'CATGAG
AAGjAcTTTAA
TGCGTAAAAA
CGAGCATGAT
ATTI'I"IAAT
CGGCGATGAA
CTACGATGTT
T1'AATTTTAG ?rrTTrrrIAAT
AAA.AAAAGCG
TAATTTGAGT
AGCCGCTGAA
TI'CTCCCGGT
GTIT'GCGTG
AGGCGTGAGC
TGAGGGGGCG
CATTAAAAC
TATCGTTA
CATGTGTGCG
GGTTTrCTCAA
GAGCTCCAAA
TGAAAATITAC
120 180 240 300 360 420 480 540 600 660 720 738 INFORMATION FOR SEQ ID NO:1254: SEQUENCE CHARACTERISTICS: LENGTH: 2871 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1 .2871 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1254
TGGCAAAGAA
AAGAGGAATI'
?ITGATGATAA
TGCTISGTTGC
AAAAGCATTA
AGAGCCATZ'
AAAACAAGAA
GAACGCTAAC
TAAGGAGCTI!
TTA TITAGA
TTCATTCGCT
TAAGGTAGAA
GTAAGGAATA
GAGATTAACG
TTAGATTACC
GACTTCAAAG
AATrGCGATT
AATCATTGCG
ATGAAArrl'r ATCCGTrAGA
AACAGCAAGC
AJAGTXAAAA
TCGCTAAAAA
TGCGTT'mGA
TGTCGCTCAA
AATGCTGGAC
TTTGATTAAC
AGAA TI'TAC
GAAPLCTCAAT
AAXTCATC
POUS 9 6/O091
?Q
RPEAMS 18 DEC 1996
AACCGCCTAG
GTAGAGCTTTI
T1'TAGCGCGA
AATAAGGACT
TTTTATCGTG
GATTTAATGA
AATGGGGAAA
AGACAGGCGA
TTCACTGAAG
AAACTTGGCT
GAATTGAAAG
TrAGGCATGC
TTCACGCAT'
CGCGTGAT'G
GAATTAAAGA
ATTIGAGGTCT
TTTTATIGCCA
GCI'I'ICAAGC
GAATGGATCC
GAAGAGAGCT
GCTTTTGACA
CTTGATIGATIG
AGCGTCAAAA
AAGCTGAAAC
AGCCTTGAAG
CCTGGCGT1G
TACCGAAAA.G
GAAAAAAATT
TTAAAGCATG
GCGCATTTTA
ATTAAAGGCA
AATOGAGAAAA
ATTCAAACCA
AAAATCGCGC
TTrCAAAGTTG
AAAGCCAAAA
TTAGAAGAGT
AGCAAGATTG3
AGGCGCTTI'
TT'CATT1ATC
CTTTTGAAG
TTAAAATTT
!CCTTACAT
'tAAGCGTGGC ACGAGCATTr
AI'CCAAACA
CTCCAAAAGA
GCGATGAAGA
ATTATGTGAT
TTIr=AGCCT
AAAGCGATCT
ATGGTAAAGA
ATI'TAAACGA
AAAAACGCTA
CTIGTGAACAT
AAAATGATGA
ATCCGGAATI'
TTAAAGAGAG
GTAATGGGCA
TCAACACGAG
GTGAAAAAT
AITrCAGCCA CTG3GGTGGQA
ACGCTAAAAA
ACCAACGCCA
CAAACGCTGC
CGATTTTAAA
AAATCAAATI'
AACAAACCAA
TTAAGGATTI'
AAATITATGA
AAAAGGTATC
AGCTATACCC
TCGTGCA'TrT
TCCAAGAAGT
AAGGCGAGAT
GTGATIGCAGA
ACTGCGATTIG
TGTITAAAGAT
ATGAGCATT
TCCCTGAVI'T
CTAAAGGGAG
ATAAGGTTL'D
ATGvGGGATAA
GGCCACAGG
TATGGGAATG
AATCAAGCAA
AAT GATTTC 'rrCTTrAATO
AAGCAAGGAA
TTAGATGAA
GCTGTCTA
CATCACTIGCG
GTCTGTITITA
CAGGGAAAAA
TAAAGTAGAA
GGAAAACAGC
TGAGAGCGAT
TITAAAGGGC
TATTGAAGTC
CGATAAAGTC
AAAGAGCGTG
GATI'GATAAG
TAGCACAAGG
GCTGGTGAAA
AAGGTTAGCG
AATGCTGGAA
GTI'CCAAAAA
AGAAAAAACG
CGCTC7I'AAA
AAAAGAGCAT
CCCTAAAGAT
AACCTGOCAT
TAATCAAAAA
TAAAAGGGTI
GAAAGAGCAT
CGATCCTTAT
GCTGTI'AAAA
GCTTIAGCAT
TACCGAAACG
AGACAATITG
TATCTI'TG
CAAACACACT
TAACCCTAAA
GGATGATGTG
AGCGGTAAAA
GGTGATCC
TT GAAAAAG AAAAACC ITA
AAAGAAATCG
AACCTT17AA
GCGCATAAGG
AAAGGG rl 1
GTGTATAAI'I
TIGAAGAAAA
GAAATCGCTC
GOCTATTTTC
GATGCGGAAA
ITTTrCAAAAG
GATGGCAAAG
ATGGATTITA
ATCAI'AACC
'TrTrGCCTGA
AAGGTGGTGA
AGCAGTATCA
CCTAGCGTGA
CAATCTTTG
TATTTAGAGA
ATGCTITTI'S
GACAGCOAAA
CGCATAGAGC
A'TTCTAAA
'TI'CATTAA
TACGCGCTGT
TATAAAGAI'
GTGCCTAAAG
AAAG ITAAGG GCGCCITrTGG
GATACAGAAA.
CTCAAAGAGC
GTGGTTAAGG
CTGCAAGAAA
TT TATI'CCCT
CTGCAAAAAG
GATTACGAGC
GACGATCCCA
GGGGAGCGTI'
CGATCGTCAT
CTAAGAAAAA
AAATTGAAAA
AAAGCGTTAA
CTCTI'I"'IA
ATTATAAGGA
GGAATAAGAC
TATTCAATr
TGAGCGTGGG
ACAACTTAAA
TTrAAAGGC
ATGACCCT
TC'I'I'I??AA
CTAAAGACGA
ATAAAGAAAA
AAGGCI'AAA
CTAAAAACAA
TI'AGAATAGG
GTAAGAATT
ATATCTI!AGT
TITI'ATTI'I
GCAGGGGCGT
TAGATGAAGC
TGATACCTAC
ATGGGGGTGA
ATOCCI'ATI
GCGC'rrCoi'
TGAGTGAAAA
TAAAAGAAAT
TAGATI'ACAT
ACGAGI'TAA
CGGATAAAAA
ATAAAGAAAC
AACACAAACA
ATI!ACTACAC
TAAAGAGCGA
ACTATGATTT
ATATAGACAA
GCGGCACGCA
ATAAGGCAGA
ATCTCAAAAT
ATAGGGATCT
TATCAAACTG
TATCATGTTr
ATACAACCGC
GAATAAGGAT
?I'ACCGCGCA
TTGTITGGAT
TG3AAAGCAAA
CAGCGCCACT
CGAGTGGGTG
CGCTTTTAAG
G'ITA=rGT
AATGCTCGTG
AACTI'TAGCG
=IIATI'AGAG
AGACTATAAA
AGAAGCAGTI'
CCAAGAAATC
CGATM'IrACA
GAGCI'CAAA
GGGGTCTCGT
AAATATAGGG
AAGGAT1TGAA
CATAAAGAC
CAA.CCATGCA
GAATAGAGGT
CGTGCCT'TGC
TAAAATGAGC
GCAAT*I'MTI
GATACAAACA
OATI'rCTGAA
CGCCCTAGAT
AGAAAAATI'G
TTTIAAGAAAA
AGACAGAACG
CCCGCTCAT'
GAGCCATTT
TGGCGT1'C
CGCTACAGAA
GATCTTGC
TGCGTATCAA
CAAAGTGGTT
T
420 480 540 600 660 720 780 340 900 960 1020 1080 1140 1200 1260 1320 1380 1440 1500 1560 1620 1680 1740 1800 1860 1920 1980 2040 2100, 2160 2220 2280 2340 2400 2460 2520 2580 2640 2700 2760 2820 2871 INFORMATION FOR SEQ ID NO:1255: SEQUENCE CHARACTERISTICS: LENGTH: 747 bass pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-.feature LOCATION .747 F'CI/Us 9 6/091T 898 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1255
TGO'ATGCGT'
T-rAGACATTA
GCGAAAAACA
GAATTC'AAA
GAGCGTPI'GA
ATGACTTCAT
TTAGAAGAAA
CTAGAAA.AAG
ATGATAGGCC
GTGGATTTCA
CTAGATGGGA
TACACI'ATA
CATGTG1 17I1 TTrATTTAA
AAGGCAGCTC
GCTTACTAGA
AAGAACGCTT
ATAGTA ETTA
TCATCAATT
ACAAGATA
GGCGCTTGAA
AAAATCAAGT
TTrGTCCCAAG TTI I'rGGAGC
A.AAGCGCGGT
TAAGCGGTGT
ATTCCT'rrGG
TTCTATATC
CAACGTTCAA
GATTTTAGAA
TCC'ITTAGAA
AGAAGACACA
TGGCCTTGTC
CGGGTI TT1G
CTTAGGCTFI'
CGCTIGAAATC
GGGGGTGTr
GTTGAAAAAC
GAAAAAC
CT TTT'AGGGA
AGCGACCGGG
GCGTATI=I
GCTTTAAAAC
AATCCAAAAA
CACAGCGI'I'
TCTCACAACC
AACGCCCACA
ATAGGGACTA
AACATAGGCG
GTGGGTGAAG
GCTTTTAA
'TTI'C'rrAT
TTAAAAGCGC
TTCAAGCCCA
TAGAAAACC
TGACTI'ATAC
CTCTCAACCC
AAGCCATAGG
AGCGGTGTGC
kITTCAAGCA
ATCAAGTGCT
TI'CAAGCGT
GCGAAGCCAA
rTTTATTTT
CI'GATGAGC
AAACA ITAAG
TGATTTGAAA
CCCTACTTTIC
TATI'GTGAAT
CATT(CCGTG
TTATAGCGTG
AGAATrAGTC
AACGAGCGGG
TGAAGATCAT
ACTTTTAAGG
120 180 240 300 360 420 480 540 600 660 720 747 INFORMATION FOR SEQ ID NO:1256: Ci) SEQUENCE CHARACTERISTICS: LENGTH: 462 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular C(ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-.feature LOCATION 1 .462 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1256
TGGTA'ITTTA
TCTAGGAAT
TTCTCACTTC
CCTGAACATT
GCGTITGGCA
GTTTCACTAT
AATTGGTGGQ
CAAAAGATT
AAAAAGAAAG
GGTCI'TAAG
?1TGTCATI!AC
TGATTGGGTG
AAAAAAGTAA
TGCTTGGCGC
CTGTCTTTr
T'TTTGTAA
AAATCCCATG
GA.LTAGGGGC
AGCGGTTAAT
GTI'ITrGAT'
GATTAAA
T1'TACCAGCG
TATAGAAGCG
ATATTC4GTG
GTTATACATG
AGGCAT"I'IG
AGAAGTAGTG
TCTr1'TAGTG
ACCCGCTT
CATTATTTT~
GGAGCTGATC
GATCGCTATT
AAAAAATCAA
CATCTTCAAG
CAGT'GC?1TG
GGGAATITT
GAATTT1CTAT 'I GTATGGTT'
TATTGGTGGG
AT
AAGCCGC'rrr
CGTGAI
GTTrATTIGATG
AGCAGACATG
TGTGAGCGGC
TGGCTTTATT
CTGTGTGATA
INFORMATION FOR SEQ ID NO:1257: SEQUENCE CHARACTERISTICS: LENGTH: 228 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genornic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: PCIUS V6/U9i2.2 .f4j ~U A (j 899 ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KFX: misc.fieature LOCATION .228 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1257 TGGGCGAAAG GCGCTGGGGC TTTAGTGCTT GAAGAATACG AGAGCGCGAA AAAAAGAGGG GCTAAAAT'I'I ATGCAGAAI' TGCCGGGTAT GGCGAGAGCG GCGATGCTAA CCACATCACA GCCCCAGCCC CTGAGGGTGA AAGGGCTT AAAGCCATGA AAATGGCTTT AGAAATGGCG AAAGTGGAAG, TATGCTATGT GAACGCCCAT GOGGACAAGC ACGCATrA INFORMATION FOR SEQ ID NO:1258: SEQUENCE CHARACTERISTICS: LENGTH: 333 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .333 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1258 120 180 228 ACGCCCAT1G GGACAAGCAC GTGTTTGGCT CTAAAGAAAA TGCTTGGGTG CTGCGGGCGC ATCI'ACCTC CTACCATTAA CCTAATACAG CCAGAGAAAA GGCACTAATG GTGTTGTGAT GCATTATAAC GATTGGTATG AGTCCCTCCT GTTAGCTCCA GTrrAGTAGCC GTI'ATTTCTA TCAAGAAACG CCTGACCCAG GCAAGTGA.AT GCGGTGATGA 'TTCAAAAAA CC
AAAGCATTGC
CTAAAGGGCA
TCATGGCCAT
AATGCGATCT
GTAACTCATT
GTTAAAAAAT
GATI'GGGCAT
GAATCAAGGG
GGATTATATC
TGGTTGGT
INFORMATION FOR SEQ ID NO:1259: MI SEQUENCE CHARACTERISTICS: LENGTH: 567 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE:*NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 5S67 AM At 2DS4.E FT PG7' ,3 /09V2 IPEMAJS 1 8 DEC 1996 900 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1259
GGCCCAATAC
AT0CITTTA.
TACCACATGA
ATGGGGCGTT
I llAA TTTG
GCGTTTGCCA
ATTAGAATGc
GTTTAGACC
ATTAGACOGO
CCTAACGvGCG AAAGCGCTCC AGCAATG.
GTGCTGATGC 'ITTAAAC( ACAAGCTIrr 'TTrAGAG TCGA'I'TCCTT AAAACTA( ACAAACCAAG CGTGTA AAAGCATcAA CAAT~c AAAGCTCTTC AGGCGAG~ CTAACArrl' GATAGAG~ TGTcTTTrrw GGAGTGG AGAGCCTTAG T~rGAG
AAC
GAT
:GT
:TC
kIAT k.CG
;AA
AAGC IIr
AAGATTGAGA
TTGTITAAAA
A6ACACTCTCA ATCACTrC.A
AATATIGATGG
G TT7rCAT
ATIGAAA.AGGC
TACGACTTTG
TAGCTTTTAT
ATITAATGOG-
ATCGTAAGGA
AAGAAAACGG
AGGCTI'CAAG
GGTATTCGTA
ACGAGC?'rAA ATGG~rTTGA
CCTTACAAAA
TGTI'GGGGGA.
GGAGCGATCC
TT~ITCTATGAA
GCTITrATCG.
TAATCCCCTA
TGVI'ITCCT
AACGGAATAC
'TTTTATGGAT
GATCAAGCTC
120 180 240 300 360 420 480 540 567 INFORMATION FOR SEQ ID NO:1260: SEQUENCE CHARACTERISTICS: LENGTH: 963 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENS.E: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc..feature LOCATION .963 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1260
ATGGAACAGA
AA.AGATATIT
CAGATTCTAA
AATATCCATT'
TTTATACAGA
GACAAAGTGT
GAAGAAACG
ACTTCATTAT
GTCATTAT1'r
CAAGAACOCO
GAAGAAAAAA
CAAGGCAAAG
ATTTGGTAG
AAAAGTTATC
CTTAT'rCTTA
TTATACGAGC
CAA
ATAAAAAAAG
CTGGAACGGC
AAGAAGTrGG
CTATCTTGGA
TTTTAGAGCA
GTGT1TIAA
CAAAA.AAACC
CCAAAAAATC
TAOGGTCGT
CTATrAAGCC
A=TAGAGCC
AAGCGATCAA
AAGTGCATTGA
CTTTAGAGGC
AAAACAACCA
CAAATAAAGG
?I!TAGAAAAT
TTTAGAAGAA
AGCGGCAGAA
AAAGCGCTAT
CGAGTATAAA
AGAGGCGTG
CCrAAGGTT 'ITCCAA6ATIGG
TATCATTCAA
CGACACCAAA
AACGCCTAAA
AGAAAATCCT
TI'TAGATCAG
TAAAAACCAC
TCAAGAACAA
TI'rAACGCTC TTAGATCTTT CTGATGTTCA TTATCGCTTA AAAATI'TAGA ATI'rGCAAGG CGACTAAAAT GAGTCmTAT CAA =GTOCA ATGTTG GCGCATGGGT GGAGAAGAGC AAAAACAAGA GAATTGOATT ACAGCATCAA
AAACCCTTTO
AACAGCTCTT
AATAATTCTr
TI'AGAAGAAA
AATACCAT
CGCTTGTT'GT
GATTATAACG
ATCAATGCAGG
TTATCGTITTT
CTTTAAAAGA
TCAATGAAAC
AACACAAAGA
ACATPATCCC
CTTCAAAA
TACGCITTGG
ACAGCAAAAC
CCCAATACAA
AAACATTTCT
TAAAAATG
CGCTTCTAAA
TGCTAGGGvGT GAAAGAATTTu
AACAAGCCCT
TCAAGCCAAT
AGGGTGGTT
AGAGAGAGAG
TAATCCTACA
ACAAGACAAG
TAAACGAGAT
GGTTTTAAA
GCATGGGCAT
TAGGCOGTTT
AGCGCTCCAG
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 963 INFORMATION FOR SEQ ID NO:1261: SEQUENCE CHARACTERISTICS: LENGTH: 345 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular IPEMJS 183 DEC 1996 901.
(ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1 .345 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1261 AGGAGTGGGA ATACGACTFI' GTITI'GAGTA GCGATCCTGT AATCAAAACG CGTXTI'AAA TITI'ATGATG AAAAC ETAAA ATCGCTCT1'A ACTTGCTTGA ATCA TITTAA AAAATGGGAT
GCCTTACAAA
GGAGTFrAAG
AATAAGCTCC
GATCATTCAA
TGGCGTGCGT
TAGCGTGGT
AGATCAAGCT
GAAGCGAGCG
AATAACCCT'
ATCATTGCTA
'FrTATCCATA TTTGAT GCGA
CCCTAACGGC
GGAAATATTG
TGTGGCAACC
AAGAAAACAG
TCACTGACGC
TGCCT
GAGAGCCTrA
GCTGAGCGTG,
CAAAATCAT
ACAACAAGAA
AAAAAACCCT
120 180 240 300 345 INFORMATION FOR SEQ ID NO:1262: SEQUENCE CHARACTERISTICS: LENGTH: 615 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc_feature LOCATION .615 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1262 CGGTCTCTAG CGTGCTGGCT AAGATI'GAGT
ATCGTI'ATT
CTTTATTTG
CTCAGGCGCG
AGGGCTTGGA
ATCTCTTCTA
TTTAACAATT
AAGGCGCTI'A
TTGATCTTAA
TTTTCAATAA
TGATGACTT
AGATGCAATC
TAATAAAAAA
AACACCAGGT
CAGCCCCCTT
TGGGCGCGTT
TCGCCACCGC
AGCGCAAGGT
GAGCGGGTIT
ATGGGTCT1T T1'IGTCTAAC
AGAAATGATG,
TCTTAAGCAA
TATI'GGTI'TG
AGGTCAAGCT
TGCAGGGTT
GTATGATI'TA
CTCT1'TAAGG
GTTACCACGC
TI'GTATAAAA
ATTCTTAATG
AGACCAAAAG
AGCACGACAG
TTTGGGACGG
TCTI'ITGGAG
TI'AGCAGCCA
TCGGTTTATG
GGATAATCAT GTTCGATTCA TTGTTrAGT
GCATTGTATT
GAGCGCAAGA
GTATTCTAAT
GT'I AGTIGGT
TAGTTGAAAT
TGATCGCACC
TTCCAGCCTA
TGCAGATGCA
TI'GGATI'ICG
AAAGATTGAA
CGCTCAGAGC
GAATTGTTGC
GI'GAGCAT1'
TTTAGAAGCG
CATTATTT1CT
TTCTTITTAC
AGTGGATATI'
120 180 240 300 360 420 480 540 600 615 ?I'GTCTTCTA AAAAA INFORMATION FOR SEQ ID NO:1263: SEQUENCE CHARACTERISTICS: LENGTH: 408 base pairs B) TYPE: nucleic acid STRANDEDNESS: double IPENS 18 DEC 1996 902 C.D) TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .408 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1263 AAGGTI'rrA CCTTrAGTGG
ACCTATAAAG
AAAGTGATAG
GAATACAACT
AGGGTGAGTA
ACGATTAAAG
TGAATTACGA
ATGTGATGCT
AAGAGATI'GC
AGATACGCAT
CTTTCCCGGA
TCCGTGCGGA
AAGCGGGGrI' TAACTA'rrGG TG TrIATTG CTTGCCT 'CT
GGATAAAGAC
CACTrTCAAT CAAGCGAT1'G 'TTGAAAG'rr
GATGAGGACA
GCTATI'CTrA
GGTTCAAAAA
GCAAAAATCT
TTGCITTCTA
ACCTATGACA
TCITTTAATCA
AACCAGAACT
TGGTAACGAC
CTGCTAGAGC
ATATAGATAG
AAAAATACGA
AAGTGATTTA
CAAGTCCT
CAATATCACG
GCCCACTCTC
CACTCAAGAT
TCAAACCTAT
TAAAGATACT
TTGTAAA
INFORMATION FOR SEQ ID NO:1264: SEQUENCE CHARACTERISTICS: LENGTH*: 384 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULZ TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc..jeature LOCATION .384 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1264
AAAGTAGGGC
ITCI'GCTCT
GAGAAAATCC
GATCTGCCAA
TI7IIAGAGC
TCTTCACTCA
ATGAACAAGA
CAXITI!GCAT
ATGCTrGTT TITTAGATrT
GCGAGAAAAA
CTAAAGAAGA
ATGATrTCA
AGAACAAAGG
GAGTAAGAGC
ATTATATGGT
AAATAAAAAG
GAATGAAAAA
ACCCAAAGAA
AGAAAGACAG
CGTI'
GCGAr
T
TTTG
TTGTI!GTTAG
GACGAACAAG
ATI'GAAAAAG
GAGCCTGAAG
ACAAAAACGC
TrCTTTCTGG
AAAGGCATAA
CCATrGACTr
TAACGGAAAA
AAAGCCTTGA
TCAAAAAGAC
CTTTTAGCG
TAAAGAAGCA
GAATI'TAGAA
ACAGGGCGAT
AGATATI'1?r
GAGCAAAAAA
120 180 240 300 360 384 INFORMATION FOR SEQ ID NO:1265: Ci) SEQUENCE CHARACTERISTICS: LENGTH: 645 base pairs TYPE: nucleic acid STRANDEDNESS: double CD) TOPOLOGY: circular
IPENIUS
9926 (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 645 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1265
GGAAGAACAA
GATAAAACGC
TCCATAGATA
AAGACTAGCC
GAACTCAAGG
AATAAAATT
GACTACCCCA
GTGAATGAT
AAATACATTIG
AAAGAAATCA
ACGGAGTTTI'
TGAAATATTTI
TAGATATTAT
ACGATGCCAA
AGCATTGA
ATAAAAAAGT
CACGATTAAA
TTGTAAG'FIT
ATTTAAAAGC
GACCAGGAAT
TCAAAAACAA
ATI'ACACGCA
ATGGCTrTTI' TAAAACCA'rr
TTACGCTTTA
TG TI'CTCAA
CCATCTTGTA
ACTI'TATGAT
AGATCTATAC
CCCTTCTATC
CACAAACATC
CCGACTCAAT
GATGGCGGAA
TTAATATACG
CAAAAACTTC
AAAITGCATG
AACAAAGAGC
GCGCTTGA
GTGGATACAG
CCTITTGCAG
GCTTGGATGA
GCACTAGCGG
A'TrTCCCCA
AAACGCCCAT
CTATAGGGCT
CTAAGA'ITGA
AAGTCTTAGC
AAGGTGCTAT
GCGTGGCGGT
GAACGCTCAA
CGCACAACAT
AGCGCCTGAT
A'ITATACGAT
AATGGGCGAA
GGT
TTTITGCAACA.
AGTGCGCTAC
GAACGATITA
CAATTACGCA
AGAAAACGGC
AAAGACT
GGCCATTGTG
TGTTTITTCT
GCGTI'ATCAA
CGCTGAGCAA
INFORMATION FOR SEQ ID NO:1266: SEQUENCE CHARACTERISTICS: LENGTH: 342 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .342 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:l266 T1'CCTGAGGG
GGGGAATG
GePTGAGArrrG GrrACTAATG
GATGACAGAG
AGGI'AGCGG
GGAAGTTrrAT
GGGTGCTITA
AAACCGAAAA
AACGGGTGGA
ATGATGCTAT
TCTCTAGCGT
ACAGGAGAGG
TGGGCATAGC
CCAAAAAGAG
TATTTTAGCC
CTCTAGGGCT
GCTGGCTAAG
TTAAAAGCGT
AACATGATCA
CACATI'GCTA
GATGGAGCGG
AAAAAGCTTT
ATTGAGTCTC
TGTGI'GCCA
CCTI'GCTTICA
TCAATTGGGG
TCTITATI'AA
TAGAGGACGC
TTw
AGGAGTGGAA
GCGGACTG
TTATGCAGAA
AAAAGGATCA
AAGCTCTGAC
INFORMATION FOR SEQ ID NO:1267: SEQUENCE CHARACTERISTICS: LENGTH: 297 base pairs TYPE: nucleic acid iPENJ 18 DEC 1996 904 STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION l...297 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1267
AAGCTTAGCA
AATAAAAATA
CTAAATTCCA
TTAGCCAAAA
CAGGGCCACG
TGAGAGCGAT
TGATl'GATT AGCTC ITfGA ATrATGGGGC
ACTTTAGAAG
CGCTATGT
TTTCAATAAA
AAAAGTGTT
GAGTTITI'TG
TGATGGCCTA
TI'AGCCAGAA
CCCATGCTCG
ATCTCTAGCG
AATTI'ACGCC
TCACATGAAA
GTI'CCAGTAA
CTTACCCTAT
ATAGCATGGA
CTAAAAATT
GAATTAGAAT
AAGGATTAAG
TGAAACAGCA
GTATGTCAAT
AGCAGACGAG
TAAAAGA
120 180 240 297 INFORMATION FOR SEQ ID NO:1268: SEQUENCE CHARACTERISTICS: LENGTH: 768 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .768 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1268
ATCCCTCCGA
TATGGTAAAA
TATTATGATA
TATGGCGTGC
ATI!GGCTTGT
CTAGGAGTCA
TTGCATAAAG
GGCTTTGCTC
GCGATTAG
AGGGGTITAT
GTGGCTTTAA
ITTAAAGAAG
GAAGCGATCG
GCACACCATr
TAAATACTTG
AAGACATTGA
AAGGAGAGGC
ATCAAGGGAG
AGGAATTAGT
AAGTGTTAGA
ATGGTTAG
TCGCACCAAA
ACCATCTAAT
GCTATGCTAA
AATGCGAGAG
TAAGAATIGGG
TCTTAACATT
CTITAAACACG
'TrTAGGCGTI'
TCAAGCACTC
T
T'TGAGCGTT
CCAACAATCT
AAAAGAAGTG
CGTGCATTI'C
AGGGCCCGGG
CGCCATAGAG
AGCGATGGGT
CGATTTA ETC
GTTTGAAACT
CTGCATGTT
CTAGGAGATI'
ATCCAATCCT
AATTTGAGGG
TCAAAAGCAA
GATGTGATCA
ATCCCTT
AATCAGGTTG
AGCGCTTTAA
CAAGAAAGCT
GGGGGGAGA
GGCGAGCAAG
'ITAATCAAGG
TTAAACAT'rA TGATrTTTGGC!
TACAAGTGGG
ACTCTAAAGT
AAAAAGAGGG
TGGCGTTACT
TAAAAGAGGQ
TI'CTCCCAAA
GAGAAGAATA
CAATTCATAA
TCGGGGGTrrr
CGGTCI!GTG
CAGGATAC
TCGCTCCCAT
ATI'ACCCGTT
CATI'ATTGGC
GAAGGTGCGT
CITTTGAGGTQ
TCCGGATGAA
GCAAATTATA
AGGCGTGGGC
CCTTAAAAAT
CGCTAAAGCG
AGAAACGAGT
CGGGGGGTTA
120 180 240 300 360 420 480 540 600 660 720 768 L(2) INFORMATION FOR SEQ ID NO:1269: POUS 9 6/ 0912a IPEWUS 18 DEC.1996 905 SEQUENCE CHARACTERISTICS: (A LENGTH: 273 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FE.ATURE: NAME/KEY: misc-feature LOCATION .273 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1269
CAGACGAGCA
AAAGATGAAG
TTACAAAACG
TCTCCCTI'TA
TTAAAGAGCA
GGGCCACGAC
ACATTGCGTG
CTITIGAAAC
GCGC'ITCGCC
TI'CAAACACG
TTI'AGAAGTG
TTGTTTGTAT
TTTAAAACAA
TATCGTTC LT
CGCACGCAAG
ATGGCCTATC
GGCGTTTCAG
AATCAAAATA
TTAGCCI'GA
ATC
ACATGAAAGA
TATTI'TACA
CGGATITATGT
AAACGGCGTT
AT1'AGAATIA
AGAAAAGCAT
TF1'CACATGC
CAAATGGCI'
INFORMATION FOR SEQ ID NO:1270: SEQUENCE CHARACTERISTICS: LENGTH: 936 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .936 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1270
ATGAAAAGCG
GGGTI'GATTT
CGAAAAACCG
GCTGGGGGAA
GCGGITGTT
GGAAACATFI'
CTAAAACAAG
GAATIAGGAT
AATGCGCFI'
TATAGAGAAA
TATCAAAGAA
GCTAACCCTA
AGAGACCATG
CCTCCTTAT
ATAAACCCTT
TCGCGCTCTA
CTAAAAAGCA
GCGGTAAAAC
CTAGAGGGTA
TAGTTCCTCA
CGAGCGTGAT
CAAAGATCGT
TAAAACCCAA
ATATTAAAAG
TCACCTCTAT
GCAGGCTTGA
CCCCTITTTGA
TGGTTACTTC
TTTAGAACGC
TCCT1TTTTCT
TGATITI'AAA
GCCCTTCATT
TCAACGGGAT
AAAAACAGCG
TGTGAGCGAA
GTI E'?IAGAC
AGTCCCCCCC
CTATAAAGAA
CACTAACCCC
TGCGTTTITA
TTTGAAGCTT
AAAAGATCTC
TATTTTTATG
TrAATCTATC
ATCCCCATTA
TrAGAAATCG
TCTAAAGGT
GGCGATGAAG
AAAAGGGAGC
GATGGTTI'TA
TACTACCCT
GCCCAePTTAG
ACCAAACGCA
CCCAAAGAAG
TTAGAAAAAG
GTCAAATTAC
ACCCCACTCT
AATGTAT!GC
TCAGCATAGG
CTCCAAGATA
TAGTGGTGGT
CCTATCTTTT
TAGGCGTTT
GGTTTAATT
ITTGT'rrGCC
TCATTACAGA
TGCTI'TTAGT
TGGTTAAAAA
AGTTI'ATCA
AAGATTGCAA
TTTGCAAAAG
CACAATI'AAA
CAACT~
T
GATC
CCAAGAAGTG
GAGCGTTAAA
AGCCTTAAAT
AAAAGCCCTT
CAACCAATTC
TAGCGGGTIG
AGATAAGGAT
AACGGCTATC
ATTGTATT
AAATAACGCC
ATTGCCTTTA
120 180 240 300 360 420 480 .540 600 660 720 780 840 IPENUS 18 DEC 1996 906 AGCGTAT'GG ATI'AAAACT AGAAATTGMC CCTAAAGTTT TAGAGGAGAT ATCC TTCTI' ATCCTI'GTAA TATAAAAGAA CATCTA INFORMATION FOR SEQ ID NO:1271: SEQUENCE CHARACTERISTICS: LENGTH: 591 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1 .591 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1271
TGATCGI'AT
AAAGTGTTGT
TGGTCTAAAA
GCAAGAACCC
CTTGAACCTT
T 'TTGAGCG
TTGCAAGCTG
TCGCCCCTT1'
GGTATCAGTA
GCGATCGCGC
TACATGGTGC
GGGTGCTATA
AATCCATGCT
CACGAGCCGG
TTGAGATGCC
GTTTTTTAGA
TAGGGGTCGT
-TAGCT'rGCC
ACGCTATTAA
TTTAGTCAT
TTGGGTTTAT
TTI!AACC
CITTTGTGGAT
GGGGCTTGGG
TITTAAGGGG
AGACATI!AAC
T1'GCATCATT TTATrTCATC
TATCATI'GAC
TCATTATATA
GGTGTTAAAT
AGTTTATTTA
AACGCTAATA
ATCTITCTTT
CTTTCAT17AA
TCATCAACGC
GCT1TITIAT
GGGTTTAACG
GACCCTAGCA
TTCCCT1'CAG; T1TTGCTCTI'
AAATCCAAGG
CTTTI'GCGTT
TCTTAGGGCT
GCCCCAAAAT
CTrI'AGTGGT
TCGCTATT
GGCTTGCATC
GTTTGTCTTG
GAAAGATT
GATTTT
CTCCATC .T
GGCTTGTTAT
ATCGCTAGTG
ACGCCI'ATT
GAGCGATTTT
TATGCTGGTG
TGGGATITGC
TTTGCTCGCT
T
INFORMATION FOR SEQ ID NO:1272: SEQUENCE CHARACTERISTICS: LENGTH: 489 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .489 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1272 CACI'TGTCT TGTITGCTCG CITACATGGT GC ETGGGT ATGGTGTTAA ArI'TCCC'ITC SGGAAAGATT TFITAGGCGA TGCGGGGGCG TATTTTTTGG GTTTGGTGTG CGGGATITCT TCTTGCATT TGAGTGGA GCAAAAAATC AGCGTG'TIT TIGGGCTCAA TTrAATGCTT PC-iL,~ IPENUS i u DEC 1996
TATCCGGTCA.TAGAGGTGCT
ACCATGCCGG ATAA'TITGCA TI'CAA ETACC CTAACCCTITT TTAATAAGCG 7TIG'TrTCG ATCGCATGCT AT'ITAATAGG CGGGCGTF1'
TITTAGTATC
TITTGCACACC
ATGCGCG'PI'
CTI'GGACGCT
CTATGCTTAT
CTIAGGCGCA
CT'FTrATTTA
ATCCTTATTC
TATGCGCTCA
TTGAATAGGC
AAATAAAACG
AATTCTTGCA
TATGCAACCT
TTIGTGA'ITAG
AAG'TrGCGC
CCAGAAAGCC
ACAACGCTCT
GCCTTATT
CCTAGTCTr
TTTAGAAAAG
INFORMATION FOR SEQ ID NO:1273: SEQUENCE CHARACTERISTICS: LENGTH: 270 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .270 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1273
ATGAATAAAA
AAAGTGATCG
TACGATATAG
GACTGCGCGA
AGCGTGGAAA
CCATAAAAGC
CAAGCGGGGT
CGCTCTTC
TACCTGAAGA
ATAACGCGCA
CGCCGCCCTA GCCTATAACA GGGCGAAGTG GCTAAAAGGA TAACCCCATG CTGGTGGATT ATTGTATGAA AGCGTGGTGC
AATGTCCAAG
TGGGGCAAGA
TCATTCAAAA
CGCTCTTAAA
AAGTGTTTT
TCATGCCCCA
AGCTAAGGAA
GGTGGAATTA
ATGGCTCAAC
120 180 240 270 INFORMATION FOR SEQ ID NO:1274: SEQUENCE CHARACTERISTICS: LENGTH: 855 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .855 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1274 GTCAAAAAGT CAAATAACAT GGTAGTAGAA T1'AAAAAACA TTGAAAAGAT TTATGAAAAC GGGTTTCATG CTCTAAAAGG CGTGAATTTG GAATTGAAAA AAGGCGATAT TTGGGCGTG ATAGGCTATr CAGGGGCGGG GAAATCCACG CTCATTCGCT TGATCAArI'G TI'TAGAGCGC CCAGTTCTG GCGAAGTT AGTCAATGGG GTCAATCTGT TAAACTTAAA GCCTAAAGAA prmi 4;'O 109i2 IPENJS~ 18 DEC1996 908 ITGCAAAAAG CGCGCCAAAA AAAAACGTGT. TIGAAAACGT ATTAAATCAA GGGTGCATGA TATCCTAAAC AGCTCAGCGG AATI'GCCCTA ATI'GTTGCT CAT1'CTA TrT TAACGCTTCT ATCACACACC AGATTGAAGT GGCGAAATCG TAGAAAGAGG ACTAAAGAAT TGCTTGGCAT CGCATCGTOGT TTTTAGGGGA.
'AAAATAA GACGT
AATAGGCATIG
CGCTI'TCGCT
AT'GTI'GGAA
CGGGCAAAAA
TI'GCGATGAA
AAGCGGCATT
GGTI'AAAGAA
CTCGGTGGAA
CAAAAACGAA
GCAT ITAGAC
ATTTTCCAGC
CTAGAAATCG
'ITAGTGGGGT
CAACGAGTGG
GCCACATCCG
CAAAAAAAGT
TTGTGCAATC
GAAATUI'TTG
CATGCGGATC
GAGCCGATCA
ATTTrCAAITT
CCCGATIGGGA
TAGAAGATAA
CGATCGCTAG
CTrI'GGATrC TI'GA TTGAG AAATGTGT13T
CTAACCCTAA
AAAAATCGCA
TrTTCTAArrrr
ATTGAGCGCT
AAAAACTAAG
AGTGCATT
GAGTTTAGCG
TAAAACCACG
CATCGTIWITC
GATCAGCAGC
ACATGCTGTT
AGACAT'TAT
GATCAGGCGT
300 360 420 480 540 600 660 720 780 840 855 INFORMATION FOR SEQ ID NO:1275: SEQUENCE CHARACTERISTICS: LENGTH: 441 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .441 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1275 TTA TTTGCT
AGCAI'ATCC
TTAATGGAAG
GAAGTCATTA
ACTI'rAATr
GGGGATITAG
GTGGTCGTGA
CGCITGAGAA
CCTGCCTrA TCAGCGCTT CGTTAGCCAT TTCGGCCATT TAGAGCATGG CAAGATTGAA AAATGATGCT TTTAGAGAGC CTCTAATAGG CTATTCGGCT CCA'rrAGGAT TGGCTATCAA TCATCGTrr AGTGCAAATC AGAATAAGTA T
TTGATTGGCA
CCTTTI'GTTG
ACCACTTTAA
CTGCCTTCTT
ATGGCTGGAG
AGTTATAGGG
ATTCAAAGCG
CAAGCAT GG
TAAAGCTT
GCTTGGGGGC
TAGTGAATAA
CGrrrAGGGGC
GCGATGTGCT
CGGGGGATTA
ATCTAGCGCG
TGAAAA'FrCT
GTCTCATTTG
TATCACCATC
TGGGGGATTG
TTTTTATGCG
TGTGGTGAAA
120 180 240 300 360 420 441 INFORMATION FOR SEQ ID NO:1276: SEQUENCE CHARACTERISTICS: LENGTH: 837 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature
PQT
1 I' '9 iT IPENUS 18 DEC 1996 909 LOCATION .837 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1276 TCTTA'7I'
TCTCTCTATA
AACAACATCG
TTGTITTTACC
GATGGCATGG
GGCAGCCCTA
CAAGTCCAGC
GAGcAGGGCA
GAAGACACCA
CAAACGACTT
C'FTCATTCTA
GGCAACCCGG
GTGAGATrIGG
TCTAAAAGCA
G'ITATAATCT
GTGCCACTTC
CCAATGTCAA
AAGCGATGCA
AAGTGGGCCT
AAGAAACGGA
TTCCTGATGG
ATCITGTAAC
CGCAAGTGAA
CTAACGTGAT
TGGGGGATAA
ATTCTCAAGG
TAGAAGAAAT
TTCAAACCGC
TAGGTTG'ITA
AGGGATGCTC
TACCACCGGG
ATACGCCGGC
TGGCGTACGC
GAATAATITA
CACTACCGCT
AAGCGAGGGC
TATCGGTGTG
CGGGCAAATC
TTTGTITCC
C'ITAGGCAAG
GACAGATCTA
TGATGCCATG
AGTTrAGTTA
GCCCAACAAA
TTTAAAAAAT
ACCAACACAA
CCTAGTGCGA
GATATTGCTA
TACACAAGGA
TATCTCCTCA
GATGGCACGG
ACTTTGGCTA
ATCACCAACG
TTAAGGCAAG
ATCACCGCTC
CTCCAAACAG
AAGGGAAAAC
CGCACATTIGA
CTCGCGCGGA
GCAACACGAC
TTACCAAAAT
TTACAGGTAA
GCGGGAATT
TCCCTCAAAT
TGAGCGTGAC
AITTTrGTCAA
CTAGCGGCGA
GCTTITTGGA
AAAGGGCTTIA
TCAATTCCCT
CATGCTCCGC
CACCACTTCA
TTAACGAC
ITTTATCGCCA
GTT'TTCGCAA
AGGCTTTTT
CAAGCTAGAC
CACTI'TACCC
TCAAGGCT'G
TCCGGCGGGG
TGCGATI'GTG
GCTTAGTAAC
TGAAGCCAAT
CAAACGC
120 180 240 300 360 420 480 540 600 660 720 780 837 INFORMATION FOR SEQ ID NO:1277: SEQUENCE CHARACTERISTICS: LENGTH: 948 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .948 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1277 AAATGGCGCA ACTCATCAAG GATATTCAAG GCGTAGGCTr TGTGAGCCGT TGTATCTCGT AACGCTTATG AAACTAAAAC AACTCTAGCA CGATAGGCAA AAAAAGGCTT~ GCGAGTTGGC AACAAACTCG CATCOCAACA CAACGCTACA AAGATCATCA, CTATTTAGCG ACCATGTGCC GTTIAAGTTI'T TATI'AGCGTI' TI'CAACCCCC ATGCGGGCGA GCCATTCAAG AGAGCAACCA GATAGCGCTI' TTGCCCCCAA GATGTAGGGC TAGCCCCTT AACGCTCCCA TTTTACGCGC AATAAGGCGA ACCATAAAAG
CGATAAAATG
AGAATTGATC
TCATAGCGAA
GCTI'AATGCG
AGTCAGCACT
GGATAGTAAA
AGCTCAAATC
AATTATTATG
VTTAAGCGCG
TCAAAAAAGC
AGAGGGAT1TG
AACGCTAGGT
TAAACGCAAA
AAAAGCGCTC
TTCCACTGAC
CTATTGAAC
GCTAAAAAGA
?ITAAAAAGCC
CTTCTAGAAC
ATCGCTAT
CAAAGCGGGG
GAAGTGGATG
CCITTTTGTGG
ATGCTTGGGT
GTITCTCAAC
ACTCAAGCCA
'TTTGGGGAAG
TTTGAATGCT
ATAACCCCCT
TATTTTGATG
CACGGCACGG
GCGATCAAAT
AAATTGCGAT
ATAAGGAAGT
GAGCCAATCA
ATGCCCCTIT
CGTATAGCTr
GCATTTGCAC
GGCATACCGA
GTTCAAAACT
TCATTCAAGT
AAATCG'rrCA
AAGATGAAAA
TTTTGGGGCC
TTTATGTGAG
AAAGCATCAA
CGTTI'GATAT
ACTTGGCT
CAGCTGTGGG
GAGTGCACITD
ATI!GCTTGAT
ACCCTrrATTA
TGAGAGTIT
TI'TGCCTATC
TTTTTGAAA
CTTTGTGGGG
GAAAGCGTTA
AGTGTGTGGT
GATTT1TAAAA
ACTGCCCGCT
CATGAGCCAT
TGTGAGTI'G
TGCTI'ATCAA
120 180 240 300 360 420 480 540 600 660 720 780 840 900 948 INFORMATION FOR SEQ ID NO:1278: N SEQUENCE
CHARACTERISTICS:
LENGTH: 1062 base pairs A r tl r P G..
I PENUS 18 EC 1996 91.0 TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 2 .1062 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1278
CAAGGTATAA
AGTI'CTTIGCG
CAT'TI'AAAA
GCATCGCGCC
AATAAGGATT
ACTTTAATAG
A 11' TGGAAG
CGCATGCCTT
GAT1'ATGAAG
GATAAGG'ITFI
GCCC L'IGAI'
CCGAATTTGG
AACGCCCATA
GCTATCGAGC
TTTGGCATTG
TGTGCTGAGT
GCCATGATAG
AAAGCCGATA
TI'CAAGCAAA
ATGACAGCTC
TCTCTCAAGA
TGCATGCTGA
TITCCAAAAT
AGGGTTTGAT
ATCATITGAG
TAAGCGTGCT
ACATI'AAAAT
CAAAAATGCT
ATGCACACCC
CT'ITTAGTT
ATTTGAACGA
ATTTAATCCA
TGGGGGGAGC
TTGATI'GCGA
GGCGATCAAG
ITTCGCCAAG
AACACCACCC
TTTAGCCCTI'
AAAGCACCAC
GAATTTGCCG
TAAAGCCATC
GATGGCAAAA
AGGGCATGTG
GCTAGTCTCT
CG'ITGCCACG
TGATWIAGGC
AAACGAGCCT
TTCAGGTTTA
TGAGGTAAAA
GCAGACTAAA
GAGCCAAAAT
CC? GTTTA
CCTAGAAGCT
AACGCTG?1'A
AAAGATAAAG
ACAAGAATAG
AGCTCTTATG
C TITATTAG
GCTATCACTA
GCCTTGAGCT
TATI'CGCTCT
GGGGGGCA'rr
AGTTTAGACG,
TATCCAGGAG
TTAATGTrCC
AAAAATGCGG
CAAAAGATI'G
CGCTATITTA
CTAGCCTTAA
GCCCCTTTAG
TATCAAAAAA
AAAAATTG
ACATGA'I TT
AGGACGCCAA
GGGGCGITGT
AACGCGTTAA
ATCAGCCAGG
TGTCTITTGAA
TTATCAATGA
CTTTAATTT
ATAGCTTTGG
GCCCCATAGT
CTATCCCTT
TGCGTTTGGA
GCTATCATTT
AAATCAAACG
GAAAGGCGIT
AA'FITrGCAG
AGCGCITTTAT
AG
AAGCATTGAA
GCTCATCGCT
GCCTGAGAI'
AATAAGCTTG
TTTGv-AGCGT! TTrACCC?'G,
AAAACAAACC
AGAGGCTAGA
GGAGAGT
GGAAAAATTA
AAAAAACAGC
GGTTAAAAA
TCAAAGCGCG
CCCTAAAATT
TGAGGA'TI'G
CGACAATGCC
CCCITIAGAA
2.20 2.80 240 300 360 420 480 540 600, 660 720 780 840 900 960 1020 1062 INFORMATION FOR SEQ ID NO:1279: SEQUENCE CHARACTERISTICS: LENGTH: 768 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1 .768 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1279 AGGAATAATA TGGCATACAA ATATGATAGA GACTTGGAAT TTTTAAAGCA ACTGGAATCT AGTGATTTAT TGGATTTGTT CGAGGTGC IT GTrTGGTA AAGACGGCGA AAAAAGACAC .ATGAAAAAC TCACAAGCTC CATAGAATAC AAAAGCcATG GCGATGATTA CGCTAAATAC IPENIUS 38 DEC 19 6
GCAGAAAGAA.-TCGCTGAAGA
AAAGGTGAAG GAGTCI!ATA AATTACAACA AGAAAACTGA GAAAGAAGCC TAGAAGAAAT ATAAAAAACA CGGACAATTT AAAATGGGAG GCTITAAATC ACCAITCTAG GGCGTGGTT TITTAACAG GCCCTGTTGG GGGCCGGCI' ATAGGGTAAC ACGCAACAAG CCAATGAAGA G ITGCAATAC
CAAAGAGATI'
AACGACI'TA
GGATGATGAA
GAACAGACAA
TI'ATCAATTA
ATCGCTTGCG
CTGGATCATT
CATACCGGCA
TAAGAAGTCG
TATGGGAGCA ATAGTTTTGC TTATGCGATG TGTGCGATAA ATTGAACAAA ACATCCTI'TC GAAGTGAAAG AAATGTGCGA GCCTTAAGCG CGGCGACTT GCTGTCATI'G TI'GCGAATGC GGCAATCAAG TGCTIACAAG ACAGGCGTAT GGACAGCGAT TGCATI'GTGG TCGCCACTr TI'GCAAATAG, AATCCGTI' GAGTI-rCATT
AITAAAGGTC
TAAAATCITA
TGAATI'GTCC
AACGCTGTTTI
GGTTGCAAAA
AACTCTGAGC
TGATATI'GCA
ACGCCTAAAA
240 300 360 420 480 540 600 660 720 768 INFORMATION FOR SEQ ID NO:1280: SEQUENCE CHARACTERISTICS: LENGTH: 303 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .303 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1280
GTTATXATAT
TTAGAGTCAT
CAGAGACAAA
TCCGGTAAAT
TTGGCGGCTA
CGA
TTTTGCTAI'
'rrTTGTGGGT
AAGACATGGA
CTTTACACCA
ATGTTI'TCT
GTrT1' TTTA
AATATTGACC
ACAACTITATC
AGAAACACAA
CAWI'GGTCTG
GGAAATAAAG
ACTTGGTGT
AATGGGATTG
CAAGCAAATA
GTTIGT'rrTGG 'rrrrCAGTAT
GTTTGGTCAT
ATAGGATTAT
AAACCGATAA
cTGTITTTTCA TlTATTl'GCTI'
GCATGAAGAT
TAAAGCAAAT
AGCATGGGAT
CATGATCAAG
INFORMATION FOR SEQ ID NO:1281: SEQUENCE CHARACTERISTICS: LENGTH: 354 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .354 (xi) SEQUENCE DESCRIPTION: SEQ ID, NO:1281 0Cij 0 91.2 IPEA/US 18 DEC 1996 GCGGTGAAAA AAGTAGAATC TITAGTGATCG TGCTCACAAC CCTCAAGTGG ATAAGGATAG ATCGCTATIT CTAATAAGGG 'rTAAAACACA AGGTI'TCCAC AAAAGCAAT TGGACAACTT1
CATGAATGTG
GGCGTCTI"IT
CACTGATI'CT
rrrCTITTAT TTTGGcTAAA TATcAAAGTG
GTGCCTTTCA.
GTGCAAACI'
AAAGATGTGT
TTTGACGATA
GACACCCCTA
GTGGA'TTAT
TTGACATCAT
CAAAGCTTCC
TGGAcAAAAA
AAGAAATCAG
TTGTCTrGCA
TGCAACTAAC
GCTTGTGTrG TATrAGCATI'
ACAAGTTACG
CTTTGAAAAT
AGGCGATAAG
AATC
120 180 240 300 354 INFORMATION FOR SEQ ID NO:l282: SEQUENCE CHARACTERISTICS: LENGTH: 336 base pairs TYPE: nucleic acid STRA.NDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .336 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1282
CTACACAGAC
ATTGGCTCAA
TTTATGGAT1' CTTGCTrAA AACTT1GTI'AG
GTTGATACGC
AGGCGCAAGT
ACGCCCCTI'A
TAGGCTCAGC
AAGCGACCGG
TGAGAAAAAG,
AATCCCATGA
TAGAATTAGC
TATCGGTCT
TTCT(3GCAT
CATGGGGI'A
CGAGATTTTA
GGTTT'ATAGC
CTI'ACACAAA
TrAGGGACGG
GACACTAAGG
TTGGTAGCGA
GTTACCAAAT
AAAGCC
CGACGACT
'rrATGGGGAT
CGATCATGAC
TCCCTGCGAT
GGGATATITTT
AGTGGCCACT
CATGCTCACC
TAATTTAGCC
TGTGATTTAT
CCACCATCCG
120 180 240 300 336 INFORMATION FOR SEQ ID NO:1283: SEQUENCE CHARACTERISTICS: LENGTH: 417 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL-
NO
(iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .417 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1283 AACCATAAGA 7ITAGGGGTTA TGAAAAACGC ATGGCATTAG ACAAAAGGAT T1GGATGCAT \\I-rTATCTTT TGCCTTTTGT GTTI'ATCATC CCCTTGTTGG TGGTTIT T'ITGTI'GAT'r PCTUS 96/0912 IPEN1JS 180EC1996
?I'TGAGAGTA
CTCTGGG
TATTGGGCGT
GCGCAGCGAT
AAAATCGCTA
GTGCGG-II
TAGTGTFTDV
GCGTTATITTT
GGCTAGTCAT
TcTCTITATT GAGcTTGAAG
TATCCCTTTC
ATTAGCGTTA
TCCTTTCACT
GTTGGCGCGA
CAAGGGG'rTr
AGGAAACTCG
GTGGATTI'A
TCTATCACCT
TTI'GATCAAA
A ITATGCCAT
ATCGGTGGCT
TGGGATCGAG
TACAGCCTAG
ATCAACCCAC
AGGGT TCT CTTTGCGCTr
CAAGCTTGGA
CGAGCCTGTG
INFORMATION FOR SEQ ID NO:1284: SEQUENCE CHARACTERISTICS: LENGTH: 930 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .930 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1284 TI TGTGGGA
AAAAAGAAAT
ATCTGTGCGT
GCTAAACATT
GATGCGTTTG
GTCAGAGCCT
GTTGAAGGTT
AATAAGAAAA
ATGATAGAGG
CTTATCCCCA
TATAAAATGA
GCAGGATI'GT
CTTAAATTCA
GAAGGCATTG
GAAGTCAATr
AACTTGGATA
CACTAAAGGC
GGAAGATT1CT
TAAGGAGACT
GGAATATCCC
TCCAAGAAAC
ATGTGAGGGT
TAGAAGAAI'
GGCATTTCTI!
AATGTAAAAC
TACCTITAG
ATGACGCT
TAGGCGTAAC
'FrCCTGTTGT
GGTTTGCGTA.
TGCCTGGTGA
CAATCAAAAA
ATTGAAGATA
TTTAAAACAC
TCTTCTAGGG
AACGATI'GTC
TAAAGGGATC
CAA'ITCCGTT
GGTAGATGAA
GAGTATTCAA
cATITATCCAT
CGATGCGCTC
TGGAATGGAT
CGCTGTCGCG
GGGGAGTGTI'
TTrGAAAGTG
AGTTGGCATG
ATI!AAAACCA
AAGATTACCA
TTGATGAAAA
TTCAAGAGAG
G7171' CACAC
ATAGACGAAG
GCC 1-TTrCAT
ACGAAAAAAT
AGAGTTIAAGA
GTTGCATCAG
GCTATCGCAC
TTGGATAAAT
CAAGTGGGGA
GCAGGGGGCG
CTAGAAAAGT
ATCACTTCTC
CGACACCATG
AGAAGCCATT
AGAGAGAGT'
ACACTCAAGC
AATGGGGGTT
TTAGGGGGTI'
GCCTTTCAGA
TTCAAGAAAG
GCGCTGCAGG
CCATTCAAGC
CTGTGGGCGC
GGACTCTCGT
CAACCGCTGC
GCTTTAATGA
TCTTTAAGGA
CAAAGCATA
GATGTGGCGT
ATTAAGCTrTC
CGAAGCCGGC
TAAAGGTTT'
GAAAGTCCCT
CGCTGAAAAA
AAAACAGGCT.
AG 1TGCTGGG
AGGGATGATC
GAGTTTGGTC
TAATGG'TrC
TGTTATCACA
TGAGACGGGT
GAATTATCTC
120 180 240 300 360 420 480 540 600 660 720 780 840 900 930 INFORMATION FOR SEQ ID NO:1285: SEQUENCE CHARACTERISTICS: LENGTH: 1257 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori P~g GT>7±L IPENS 18 DEC 1996 914 (ix) FEATURE: NAME/KEY: misc_feature LOCATION .1257 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1285
ATGAGGTCT
GCGGTTIA
GAAAATACAG
TCAGTGGGCT
TATCGFFI'GA
ACCCACTATI'
TACAAGGGCG
AATCCTGTAG
AGCCCGCACC
AAATTTTTAA
TTAGAAGATG
TCCAGGCCTA
GTTAGAGTGA
GAAGATGTGA
ATCGCTCAAA
TATI'ATAAAG
GCCATGGGTG
GACTCTTCGG
GTGTATCGTT
CAGTTCGTGG
GATAAAGATG
GGATGAAGAA
TAGGGTGTTIC
ACGATAAGCT
'rrGAATGGTC
AAAAAGACTC
ATGATGAGGG
ATAAAATITTC
AAAGCGTGT
CAAATCCCAG
ATGTGGGGGC
GGCAAAAATA
GCGTGATAGT
GTCAAAACCT
TAGCTI'ATCG
CCACCAACAC
TCGTCGCCGT
AAACCTCTGA
CCTI'GATCCA
TTGAAGCCAA
ATAAGGACAT
G'TTAGAGTC
AAAATAC'ITC
TTCTACCAGG
CCCAGTGGTC
TAAAGTCGCT
CAAGCTTAAA
GTTAGAAACA
CAAACTrTCA
TGCAAGCCTI'
CGTTTCTAAA.
TGTAAAAAAC
CCGCTACCAA
GGAGGGGAAA.
CACACGACAA
CATTACGCT
TTCCTAT GTG
AGATAAAACG
TAGGCCTGAA
ATGGGAAAAC
CTCCAAAACC
GAXAGTGGGC
GCACCCAAGC
ACGCTrAT
AATCATACL'
CATI!CCATTA
GACACTTATG
AGAATCGCCA
GAGAGTI'CCT
GAACCCATI'
GAATACCCTA
TACATCATI'C
CGCTTATCG
ATCATCGCCG
ACCAAAGACT
ATTGAATTGA
TCCAATAACC
GATAAGATAG
CATCTrGAAG
GCCCCTATCA
AACCCAAGCC
CC TrGCGTT
GTGGCI'ATC
AAAGAAGTGC
TGCAAAGTAG
TTTCAGCCCT
AAACGATTAA
ACA'rrGACGG
CCATTAAAAA
ACACTTACCA
TAGTAAAAAC
AAAGCGTGAA
AAAGGCAGAA
TGGAG'TT
AAAATTTCAT
TGCCCAAAGA
GTTGGGATAA
GCAACGATAA
AAAAAGACAA
GGCGCTTACC
TCACTAAAGG
CTAAAATAGC
TI'GGGAATAT
GCTATCAGGT
GTTTG17r-17r
TGTGGTATTA
TAGTAATCAA
CGATGTGAGT
GTITwlGTTrG
CCCTTATGCG
ATI'AGCCACC
CTCCTTTATC
AGTCTTTTGG
TAAAGACGGC
TGATAAAGAT
GGGGGATAAA
AATCGCTAAT
ATCCCCAGAA
ATACAA.M'1C
TCTCACTCGT
CAAAGAGCCT
GACTATI'CAA
CAC?1'ATGCG
CACACAAAAC
GGTGAGCGTG
AGAGCGC
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1140 1200 1257 INFORMATION FOR SEQ ID NO:1286: SEQUENCE CHARACTERISTICS: LENGTH: 780 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .780 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1286
CTTAAAAACA
ACTGGGGATT
GGTTTTAAAA,
ITVTAGCGC
TAACCCATA
AGTAAAATCG
TTTGCAACGA
ATTCTAGAAA
AGCGCTTT'TT
G'ITCAAAATA
ATCAGCGCGG
TACGATAAAA
CTCTAAAAGG
TAGCCATGCG
ACGATTCTAG
TTCTTGTIGA
TCAGTTA TrT
CCACAAACAA
CCGCTCAAAA
AGCCTTTAGG
TTAAAGAAGA
TCCTTGAAT
ITGAAATCTG
TCGGGGCT T
CAGATTTACC
GTTATTGATG
AAAGCTCTT'
GATTATCGCA
AAAAACACAA.
GCGCGTCCGT
TAAGCCCTTG
TTTAGCCCAA
GCATGAT'ITA
ACAAATTI
GCGCCTGAAT
CGTGTATGAG
AAGGGATATG
CAACGATTA
CTGGATI'ITG
GTI'rCGCTT
TCGGGGCGTA.
CTGCATI'CAA,
TTGGATAACC
ATI'ITCTACT
AACGCGCTCA
AAGACTTGTA
AGAATCGATC
AACCCTATCT
ACTTTAGGGG
GI'CAAAACC
AAAGATTGA
ATTTIGGTTCT
ATGAAATITA
AGGAGCTATC
GAGAAAAGGG
CTAAAGACTT
ITTTCTATCTC
ATCACGCTAA
ATTATTTAGG
TAAACAT1'IT
TGGAAGAAAG
ATCTCI'GCA
GGCAAGAAAA
TI'TTGGCGCG
TATTCATTAT
CAATGAAGAG
TGAGGAATTT]
TGAAGAATG
CCCTAG'iTI' CACTCGrTrG
CCAAAGCATI'
GAAAAAGGGC
ATGGGATCAA
GGGCGAATI'
AGT1ATCC
ATCAAAG'TT
120 180 240 300 360 420 480 540 600 660 720 780 1i461uU 916/0912.2 IPENUS 18 DEC 1996 915 INFORMATION FOR SEQ ID NO:1287: SEQUENCE CHARACTERISTICS: LENGTH: 1038 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .1038 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1287
GGCATGGTTA
GTGCTG'TTTT
ATTAAAGTGA
T-rITI'Air
TATGACCATG
GCGTTTGTGC
ATCCCCACT1'
ATTAACATCA,
AAGACTGAAA
GAAAGCTIA
AATTTGTATA
GAAGAATTGC
CAAGGCACGG
CAAAAACGCC
FIAATCCCCT
GTCCITGGAG
TTGATGACCT
TTCATTTTAA
AACACTATCT
T1'ATCTCTTC
GCTTTITGGA
TGCCGATCAC
AATI'GTrAGT
CTTTIAAGT
CTAAGAGCGC
GAGCGGGTGA
ACAATTCCTA
TTTI'GGCTCA
ACGGGCATGC
ATTTGCGCAA
ATTATITGGG
GTITTTCTCA
TATTTGGCAT
CGGTTGGGGT
TITTCTI'CCC
AGCGTTAT
TTTCATGGCG
CAF1'GTGTTIA
TCTGGTGCAA
TTTITTGCG
G TrITCTCT
GTTAGTGAGC
?1'ATTACGGG
ATTCGGGCAA
TGATAAT'TG
AAAAGGCAAT
GTATTTCACT
CAAGCTCAAG
TTATTGGAAA
AGCGATCI'A
CGCCAACCCG
TTATITTIA
CTTTATTTGG
G'rrTCGCAGG
TTAATCAGTA
CTCTTrT.U
GCTTGCGCT'
TTAGGGGTT'
GCGATTAT
TITTTGCGTC
AAATTAGGCG
GTGCTITI=
ATCAACAATC
CAAGGCGATA
TCT=TTCTC CTI'CTTI'TA TrGCAAGCGT AACGCTCGTG A'ITCCTI'GCC AGGAACCACT TGGGGCTr1TC AAGGCTrAGC CGCCTAAAAA AATGACTAAA TAGCGTTrC GCTCATCTTA
AAAAAAAAGA
ATTGGCTCGT
CTAATAAAAG
AAAACGGCGT
AAATGCGTAA
TCTTTCAATI' CTAATGATGC AAAGCCTrTG GTAAAAACGC GTTTCCTTGT TCCCT1'IAGC CGATTCAAAPI CGAATTGGAG ATGGTGCATG TGATI'TCTAC
CAAGATTGAC
GTATGTGGAT
TCTCTCTCAA
GTI 'GAATTG GGT1'GATTTT
GGCTTATTTG
TAATAAAAAT
GAGCGTGTTT
TrATr'rCCAT
GGATTTGTT
GTTTAGAAAA
120 180 240, 300 360 420 480 540 600 660 720 780 840 900 960 1020 1038 INFORMATION FOR SEQ ID NO:1288: SEQUENCE CHARACTERISTICS: LENGTH: 1845 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .1845 77N
PC.'
IPENJUS
E_ 0 C19 96 916 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1288
ATCTI'AATTG
ACAGAGCGTA
CAGCCCAAGA
GAGCATII'AA
TATAATGACA
GAGTI'GCAAG
GGTATCACGC
TI'AAGCACCG
TGCGATAAAA
GTGTTTGTGC
CGCCAAGATT
AGCTATCATG
ATGGAGTTTA
CGAAAGGITTT
GCCAAACTCA
GGTTCTACTA
AATIGGGACG
AACGGATCAG
GAATTGCTAA
CAAAAAGGCA
AAAGACGCTG
GCCGCTAATG
TCAGCCATTA
AGCGAATITI
CCI'TCCAAG
GGGGCTTTGC
GCGAGCGGGA
ATCATTAAGA
GTGCI'GAAA
AATTTAGAAA
GCCAATACCG
AAGGGGTGTT
GCAAAAAAAC
TTGAGAGCTT
AAATGCCTT
TGCTTICAGC
AGCATAACGC
AAGGTTATGA
CCGTAGGGT'
TI'GTGCCAGG
CAAGCGGGCC
'rTGCAATGGG
ATGTGGGCAC
TGGGGTTGCA,
TAGTAGAAGA
TI'GATGAAAA
ACCACAC'TIT
ATTTTGACGC
CGGATGTGAA
AAGAGGGGCT
TGCAAAAITA
TIAGTCATAG
GAGGGCT1'AA
AAGATGAGCA
TAGAACGCTI'
GGCCTAAGTC
AGGATATGG
AAGTGCCTAG
TI'AAAGATGG
AGGATTTGA
AGCCTACTTI'
CTGAAGAGGG
CATGCCTAAG
CAGAGAGCTT
GGGTTGCGCG
AGGTT1CGCAT
CCACCA.ACCT
CTATGCGAGC
GGGAATGGAA
AAGCCATAAT
CTTGCTCATA
TATGGTGAGC
AAAGATCAAC
TI'GCACTTT
TGTGGCCAAT
GAGCGCTAAA
AAGCATTCTT
GCA7TM~ATC
AATCTCTAAT
CGCTTGAA
TITA'ITTGAA
CACCAAAACC
CCTGAATACG
AATCTITAAAA
TAGGAAAGT
TAAAAATAAA
TAACGGCATG
CTACAAGGTC
CGCGATCCAT
CGATTTGATA
AAAGAGAGGC
TGGGTTGGGT
TGGCATGAGT
CATTCTIAG
TATTTAGAAA
AATATTGCGC
AAAAGAAAGC
T TAAAAATT
GTCGCTAGTG
TT1GAGCTI'GT
GT'TTITGACG
GGAGCG'ITAA
GGGATAGAAA
AGAGAAGAGC
TATGGCACGG
TCTAGCTI'IA
AGAT'TAGCGA
AACGCTCTITA
GCTATCGCTA
CTCATACCCC
GCGTGTGGGG
GACACTCATA.
CCCTTTTrTAG,
GATATTITAC
GGTAATI'TGG
AAAGCTAGAG
GAATTAGAAA
CCAGAATTGC
GCGCTCGTTA
TITAAGCCCTG
GAATTAGACG
ATCAACCCCT
AGGGAATTAT
TTTGGCATAA
AACAAATCAA
ATACCTICAA
ATG'ITACGGC
ATITTTGCGAT
ACCCTGATCT
GGGTGCCAGC
TrAGTAGAGA
GGGCGTTTT
GC'TTTGGGAA
ATTATAAAAA
T 'rrAAAAGT
CTAATTCTAA
TCAACCCTAA
GCGGGAAAGT
TAGGCTIAAT
GATCI'GTGG
?rITrAGCTAA
GCTTAGCGT
CCATTATGGA
AAAACGACCA
GCCCTGTI'AG
GGCGGGCCGT
CGAITGTTT
GGGACTTTGT
ACAAACTCAC
CGGATGGGCG;
AGGGGGCGTI'
CTCCTAATAA
TGTTTAGA
TTACAAGCTI
AGGTA
AGAAAAAAT
CCCTAAAAAC
GAGCATGCCA
TATCACCGCT
GATTAAAAA
GATGTGTGAT
TGTGATCGCA
ITTTGGGCGTG
TrTAGCGAGC
AGCCAAAGCG
GGAAATGCAA
TCAAATGATG
CAACCCCTTA
CCTGCCTTI!A
GGCAACAGGG
GGTGATCCTC
AGTCTATCCT
TGTGATCAAA
TACAGAAACG
ATrGGTGTAT
TGAGCCTITTT
GATTAAAATC
TAAAACCCAA
GGCGGTCTI'G
CACGAATrrA
CATGAGTGGG
AAACGGGGCG
CGCCTIGAAT
AACCTTAGAA
GAGATI'GAAT
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1140 1200 1260 1320 1380 1440 1500 15 1620 1680 1740 1800 1845 INFORMATION FOR SEQ ID NO:1289: Wi SEQUENCE CHARACTERISTICS: LENGTH: 642 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .642 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1289
AAATATAAAG
GTCCCTGTGG
GAGGGGGGTA
GAGCTTATCG
GAGATAAAAT
TGGTGGI'GA
TTCCAATCAT
CTAAGAATGT
AGCAGGCTCA
TAGAACACGC
GCAAGATAAA
GAATATAAAA
AGAAGTAACT
GCCAAAAATG
AAATAGGGGG
AAAGAAAAAA
ATAATAGAAA
GACGCTGTGC
?I'GCGATCAA
CGCGTGGGTG
GCAGAGTTTT
GACATGCCTT
TTTACAAAT
CTI'TAGCGCA
ACTGTGCTITI
CTGGCACGAT
TGATTAGCCC
TAATACCTGG
CAGCCCCATTI
AAGCCTGATA
AGAGGCCATA
ACTCAATCTC
GGGTCTTACG
GGTTTCTAGC
Ascfnqn-m rt-17-V /109122a IPENIJS 18DEC1996.
AGCAGTGAAG TCATGCAAGC GAGTA7I'GCG GGGGCGTTAA TTGCCCCA CTGGGGGGAT GTTGTGTGCG TGGGGGGGAG GATAAGATCA CAGAAATTIM 'FrrAGAATTG
ACTTITAAAC
TAGCGCAGAT
CTGGCI'ACC
CAAGAGAGCG
GGTTATAACG
GCTITAACG
AACATGCGT
CCTAAAGATT
TTAGCT1'TAA C TrTGAAATr
GCCC'TITTAA
CTTATT~TGGC
TAATTCAAAA
GA
TTCCCGGCG
AGGGGTGAAA
ETITAGAAAAC
CAAAGAGTGG
INFORMATION FOR SEQ ID NO:1290: SEQUENCE CHARACTERISTICS: LENGTH: 285 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc-feature LOCATION .285 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1290
AATACCGCTA
GTAGCTGI'G
CGCTT1T'ATC
ACGCAATGCC
AAGCGAGAAA
TTGTATCGI'
GTTIATATGGT
TTAAAGCACT
CGCCCCATCA
CGCTCCCATG
TTTATGGTT
ATCGTTGCI'
ACTArrl'GCT
AGTCCGGGAG
CGCCCTTTCG
GCITATGTTTI
GGCGCCTA
ATATTCTATC
t TTTrTCAT F1'TCAAAACG
CTATAGGT
AACGCACCCC
ATGCAGTAAA
CACGACATGC
CGCTC
AACTAATTITT
?I'GCACTAAT
TAATTITCTA
ACAGGGATGG
INFORMATION FOR SEQ ID NO:1291:- Ci) SEQUENCE CHARACTERISTICS: LENGTH: 1080 base pairs TYPE: nucleic acid STRANDEDNESS: double CD) TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc-feature LOCATION .1080 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1291
AAGAAAACGC
CAGAGGTGI'
ACAAATGCGC
AGGTGCGAAG
GAAAGCCTTA
CCCCTATTCT
TTATGCCAAA
GTT'ITGGTT
ATITTGAGAG
AACTGCACCC
CTGCCGATTIG
AACTGAAACT
GGAAGTCGCC
CTI'GAGTGAT
TATrATGGC
CTCGGATTT
TACCCAAGAC
CCACGACAGA
GCGGTGCGAT
TCTTTTGCTG
ACATTCTAAA
TATTAGCCGA
TGAATGCGT
TTTACCTITC
TGGCTACGCC
AAAGTI'ACCA
TATTGGCGGC
TGAAGTCITG
TAAATIGCAAA
CATTATGGGG
PCT /Qlu0912 I PEAIUS 18 DEC10 199 6
GATTTTIGTCC
*rrGAATrrAA
GCGATGCAAG
AAAGCGAE T
GGCTCTTTGA
TTAGAAATTT
TrTTTGAGCG
GAAAAAGTGG
TTGAATGGGG
ACGCTCGCTG
GGGATTATCC
ACGAAAGGGC
ACTCCCGGAC
AAATGACGAA
AAAAACTGCT
AAAACGATCT
TAGGGCCAGG
AAGTCTIGCC
TAGTGTGGCA
GTAGCGGCCT
CGAAGTTGAG
ATI'ACCCTAT
CTGATGTGGC
CACGAITCAT
GCATGGGAGC
TTGATGGGGC
CAACCACTGG
TGTCATCAAT
AGCCCAAATA
AACCGGGCTr
CGACGAAGGT
ATACGCCCGC
GGTGTTGATI'
cAAGGCTGAA
ATGCCGATTG
TCTCACTI'G
TGATTA'TT
GT1TTCTCGCT
GGGCATTGCG
ACTTTTTCTA
GATTT13TCG GGcGGGATIA
GGGGTAAGCA
GGGCATGTGA
TCTAAXI'TCA
TATGAAGCCC
TTAACCCCAC
ACCTTGGACA
GGGGCTAGAG
AAAACTTCGC
TCCATCCCTG
TTAGAAAATI'
TTGAAACGAC
CGCAAGCCTA
AGTGTGAAAT
CTCTI'ATCCA
GCITI'GCCCC
ACCATGTGAG
TGTCTAAACG
AAATCATTAG
CITTrTGCTC
GGGGGGTGTA
CCTTrAGAGC
TGCATGTCGT
ATTTACTGCA
ACGGCAATGT
TGCCATTAGC
CAACGCTCCT
AAACAGCGAT
TTITGATGAT
CGCGGAAAGG
CAAAGGC'ITA
CGAACGCGCT
CATGCTTGGC
TTTGGTGG
GCGTITI'GAA
GATIGAAAAAA
TGATAGAATA
360 420 480 540 600 660 720 780 840 900 960 1020 1080 INFORMATION FOR SEQ ID NO:1292: SEQUENCE CHARACTERISTICS: LENGTH: 1020 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1020 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1292
TCCCAGGGAC
GAATTAI'GT
AAAAACTCGC
GAATTACAAA
ACACAAGACC
TCAGATTTGG
GAAATGCATG
AATGAACTCA
TGCGAGGAAC
AAAGATI'CTC
rITAATATGG TrGCTI'CTAT
TTAGTGGGG
CAAAGAAAAG
AAAAGCCGCA
GGTTAACA
GAAAAACTAG
TGATITl'TGA
ATCAATCCCA
GCGCCAAAAT
ATACGATAAA
CCCAACAAGA
AAAAATCAGC
AACGCATTGA
AACAAAGAAA
AAT1TCCGTGG
TAGCGATTAT
ATAGCGGCAT
TGACGCCTGT
TAGGTAAATC
AAGT GGATAA
TTGAAAGTITA
AACTITGTTGA
GATACATCTA
TAAAAAGAAA
ITTCAAACCA
CATTCAATCA
AACCACGATT
AGCTCGCTT
G TCAGCAAA AAGAGGTAT1'
GACAAAATTG
AAGTGTAGGA
AAAACGCATC
TGATACAATA
AGTAGGTGAG
AATATGGAGT
GAATI~rACAT
TAAAAATGGT
TCATrACGAA
TAATAGTATC
CAAAAATTTC
TTAGTAGAAT
AACTGCAATA
GAAAAACAGA
AATTI'GGATC
ATCAATCAAT
GGAAATAATG
ATTGAAGACA
AAAAATATG
AATAACCTTG
GGCTTATI'TA
TTrGCGTTAA
TTTTTGATT
CAAATIT
m
GCG
GCATTGGGAA
CGCATGAAAA
CATCTI!ACAA
TAAAAGATTT
TTATAGCCGA
AAGCCI!AAA
TCAATCCAGG
GTTCTACAGA
TCGAATI'TAA
AATGTAAAGA
TAGAACGGCG
AACAACTTGA
GTCTI!AATCC
GTTCAATAGG
TTGCAGGAGT
CAGATTATAA
AAAAAATTGT
TAAAGCAGGA
AGAGCTTCT
AGTGGTAGAA
GATGAAAGAA
TAAATTTATA
TTITAGAAAA
AATTrGGC
GTTCAAAGAA
AGAAAGAGT
TAATTCTAAT
AGGT1'1GGTG
GGGTTTAGCA
AAhATCCCAA
GCAGGATGTG
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 TGATI'GAAGA ACTCAACGCC GACAATTGGA AGAAGCCCAT TATCTAACCG CCGCATACAA INFORMATION FOR SEQ ID NO:1293: SEQUENCE CHARACTERISTICS: LENGTH: 657 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular K/O912 IPEAIUS 18 DEC 1996 919 (iMOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .657 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1293
AGTGCCTTAT
TTTTTCAAAC
GC TIAGAAG,
A'FITTAGCGA
AAAGCGACGA
AITCGCATI'
GAATTGTTAG
ATCA'TI'AG
GGGCATTTG
TAITI'GCAAC
CATGCGAGCG
GGCACAAAGA
CGCATGAGAT
AGATGCAAAA
TCAAGCGGCA
TI'CAATCCAA
TAGCTACTTC
AAACTI'GCAT
GTI'GCACGCA
CCCI'CCAAC
AAAAATACGC
GCGATGTGAT
CCCCACCACC
TGAATTAI G
GTATTCTAAA
AGTGGAAGAT
CGCCTATGAC
TCITrTITGTG
GCATTA'ITAT
TI'TTTCCCTTA
GCCCCCCCTA
CCTTAAAAAC
CTGGCTAGAA
ATCAAGCAAT
ATTGTGGCAT
ATCCCTATTG
AAAAACGCCC
AACGCCCTGA
CCTITGAETG
TI'CACTCCCT
ATCGCTCAAA
CTCATCCATT
AATGCATGCA
AGACAAGCTA
TI'GGCTI'AGA
GCAACACCGC
TGGGCGTGAT
CTATrTI'AGT
AACAACAAGG
AAGAAAGTAT
TAGAGATTT
AAATTGAGGG
CGGGCGATGC
CATI'CCCTAA
AAGAATGGCT
GGCTII'GGAT
GAGCGCTCTG
TGAGCCAAGC
GCTAGGGACA
CTATITGAAC
TTAGAGGGC
ACCCGAAGTG
CTATTTCATG
TAI'GTAGAA
AGTGGAATT
CAAA'ITG
INFORMATION FOR SEQ ID NO:1294: SEQUENCE CHARACTERISTICS: LENGTH: 327 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .327 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1294
GGTATTAAAC
GCAGGAI'CT
TTII'GCAGGAA
ACTAATCCGC
AGCGTGCCTA
CAAAGCATGG
TAGGGGGTAT
TATCGCAAGT
TAGTAGCGGG
AAATGACCGC
TGAAAGCCGC
CTGTGGGAAC
TAACATGGCA
CTCCTCAATC
CGCTATGACA
TATCATGACC
TAACCAACAA
AATATCT
GGCACACAAG
ATCTCAAGCA
GCAGCGATTA
CAATACAATC
TACAGCCAAT
CTATATATGA ATCATCTTCT CAAGTGGTGT CGCAGGGCCA TTCCTATTGT TGTGGGAIWIT AAAGCATCGC TGAAGCTGTA TGTATCAAGG TTTTAACGAT INFORMATION FOR SEQ ID, NO:129S: SEQUENCE CHARACTERISTICS: LENGTH: 366 base pairs TYPE: nucleic acid IN STRANDEDNESS: double POT/s 9 /O912.2 iPEN/US 18D0E C 1996 920 TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .366 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1295
TITTCAAITTG
GTTGTAGTAA
GCAACAGGCG
GTAGGTGGTT
ATCAAAAGAG
GCAGGTGGCA
GCTAGC
AAAGGAAACG
CITrAGGGCT
TI'ACTGAGAC
GCGCTTTAGG
GTCAGGCGAC
'ITATCTATIT
CATGAAA TT
AGTGGTAACA
TAAAAGTTTG
GGTCAAAGGC
TG'TI'TGCT
GAGCACTAAG
TITACAAGAA
ACCAATCCT
GTTAI'CAGA
ATAGCAGATA
TACGCGCAAC
TTTTCGCTTCA
TCACTGACAG
TAATGGCGGT
TCATrCTGT
TTI'GGAAAAT
CCATAGCTAT
ATATTGGCGA
CTACAAGAAA
CACCAGTCCT
TCTAGCGATC
CTCTGATGAC
GTTAGCGGTG
GAGTGGAGGA
120 180 240 300 360 366 INFORMATION FOR SEQ ID NO:1296: SEQUENCE CHARACTERISTICS: LENGTH: 2973 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .2973 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1296 AGCGGTATAT CTATAAAGAG AGGGGTGTIT
AAGCTAGI'A
GCAGACATGC
TTGTTTGGTT
GTATITATCTG
GTGCTI'GTAG
ATGAAA'ITTA
v rCCATGA
GACAGGCTTG
GATGGGGTGA
GATI'TTAA
TI'TAGGAATT
GTI'ATTGATG
TATAATIGAGA
CAAGATITAT
TAGAGCAAGA
AAAAGGGTGT
TCCCTGAAAC
TITATTCT'rrT
CTCTTGGATT
AAAAACCTT
AGCCTAGTAA
TGAGCGCTGC
TCCI'ACTAA
CCACTTCCAA
TGTTACCCC
AAACCAATAG
AGCAAAAGAG
TAGACACTCT
AG LTTCAAAG
GGTI'CAAAAG
CAATCCCTT
TIVIWIAT?1AT
TCAAGCCTAT
CAAGAAAGAT
'TTTGTTTAAG
AGAAATGGCT
AAACTCCTAT
CAACTATTCT
AAAAGATCTC
TGAAT1'CAAA
GGATTATGGT
AGAAAGTTTT
CAATGAACCC
GATI'AIAGA
GTGGCAAGCA
CGGCAGTC
TTTAAAGTCT
TCTTCTATAT
GAACCTGT
TACAGGC TT
GGCGTGAAAA
AATGACATCC
CTAGCGAATA
C iITI'A GCA
ATAGAGTTAC
TrI'ATTTTC
CI'ATTT
TATGATATTA
GITAT(3AATA
GCCAAGCTTG
AACAAGCTGA
AAAAAATAGA
TGTTTGATGG
'rrATATTG'rr
TGATTGTAGC
ATCAAAGAAT
ACAAAGCGT
ACI'AAATCC
ACTATGAATG
CAATCAAT
ACGCI'CTAT
ACACTGTTAA
CTAATGATTT
GT'TrrATCT
AAAAGCATTT
AAAACTTCAA
CGAACAAAAA
AGAACTI'AAA
GGGGAATAGG
TGTAACAA?1T
GATGTATT
GGAGCGAGCG
CATGAGCATT
AAACAGAGAA
LITrT AGAT
GGGGGGCAT
TTATAGCGTT
AAAGAAAATC
CATGCGAGCC
CACCATAGAG
TGCAGACAAT
AGATAGGATA
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 I !26</LI5%~ /6YR/~2~ 'ba- 99e~
GAGCTCATAG
GATGGCATI'A
GCCCCTT'ITA
AAAGAAGTIT
TATTT'TAGCG
AAAATCAACG
CAAGTTrTAA.
AAAGAGCAAG
CTAGGCAGTT
AGCGTTAACG
TTCTCTATGG
TTTGATGTAA
GGCAAAGAAG
TCGCCTTIWIT
ACTTTGATAC
GCTATGGGGC
ACTATGGTT
GAGTATGTCA
TGTGTGCAAA
GAGC'FIGTGA
TCtTI'TAGCC
GATATGAACC
GATCCTAATG
CAATGGCTTT
GTTGATGGGT
TTCGCTCGTA
TGGAAATATI'
AGGAAAAGAA
CCTATTGCTG
GGTAATCT'
ACTAAGGGGC
AGTIFTAAT
TTTGTCAAAG
TTGAGGCAAA
AAGAGCTACT
'TrTACTCCAA
TTTGCAACAG
ATTTI'GCCAA
CTATTGAGAT
CTCTAGACAG
AGGAcAAACT GcATGAC1TTI
ATGGTAATIC
AATGCGTCTC
AAAATrACTT cTTCTAACAA
ACAATAACGC
AT1'TGAACT
TTGGCTCAAC
AATI'GCCTA
ATATGGATAA
AGATTGAGCT
AAACAAATGC
AAAACTTAGC
TAGCAGATTC
TAGAFI!ATCC
GGCrI'GTCGC
TTGACAATAA
CAAGTTTCT
TCCAAGAAGC
TAGGCGATCC
ACGCTATTGT
ATACGATI'AG
CTGATI'ACCA
TGGATAGGAA
TGAGAGGCAT
AAATTGACAA
TGTATCAACA
GAGTAAATAC
ACAATGCGAA.
AAAAGACTTG
TAAGCATGGA
CAGTGAATAC
CGAATTTATC
AGC rTCACC
GGGTTGCTIG
TI'TAGTGCTG
TAGTCITAAC
ITTGCCAAA
TrTGCTGAT
TTGGGGCAAT'
CCACATGCCC
CGGTTCAGGT
TAATITITCCT
AGATTATGGC
AGGGACAGAT
AACAATGGAG
AACTAAAAGC
TAATACGCTT
TATCACTCAA
GCGATI'AGCG
AGCAACAGAT
AGACAATAAT
AATGGATGGG,
AAAGGTCGCT
TAGACTTGCG
AGAACAATGC
AAGATTAGCC
AATCCTCTAC
TCCTAAAGAA
GATTATCCAA
AATAAAGGAG
CACCCCACTA
'rrTrACAATT
TATCTCAAGG
AAAATCFI'AA
GCCCCTAAAT
TTrATGCATG
TCTAGAAGGA
AGcGAA'ITAG
TITTGCTGATA
GCTAAAGGTI'
cATTGCTCT
TI'CATAGCGA
AGCGTGATGA
ACTGATITTG
AAGACAGTGT
GCTAATATCA
GC11'ATGGGA
ACAGGATTAA
CAAAAACAAA
GATGAAAAAG
GCAGCGGCAG
CT'AAATG
CCTTIGCA
CGCTTAGATT
GACGTI'CGC
CGTAGATTTG
TATITI'GTGA
ACTCAAAGCA
CCTACAAAGA
AATGTTACAG
AAACAGGATG
TATIGAAAA
AACCATAGTA
TAT
GATITAAAAGA ATACACTAAA
TFTCTTGTGG
AAAAAATGCA
ATGACGATT
CACAGAGCGA
CTTATTCGCC
TTATTATTAG
TGGGTAATGG
GCTTTGAAAA
TITTAGCCAA
TTATCACGCT
TGAGAGCGAT
CGTTAAAAAG
GTTCAGCTTC
TTATGTCCAT
GCAAAGACAA
ATATTG ITGC ATCCTITrTGC
CAGCTA'ITTC
ATGAAAATGG
TAACCAACCT
CTIT7CGGGAA
AATCAACCAA
TTTCAAAAAC
CTITTATTTG
TCTTAGATAT
GAGACATGCT
TCACTGATCT
TI7TTTGAG
AAAAAGAATT
GAAGCCCTAG
TTTTATCCAC
TCATAGATAA
AATGAATGAA
TGGTGGGGTG
GAGTGAAAAA
TTTGITGAT
TAAAAACTCA
TGGAGGCTCC
TGATATT1ACG
AATGAAACAA
CGCAGCGACT
TCCTTATT
GAGTITGAT
CGAGATCAAT
AGCAGGACAC
GACTCTAAAC
GCAAAAGCTC
AATGGGTGGG
TTGGGCAGCT
TGITGTCAAA
CAACAGCATC
TATCACAGGA
AGACCACAAT
TGGTGANTT
GATTATTGGC
TTTrACCTT
TGATGAAGCG
AAAAACTGCA
TTTrGGCTTGC
AAACGATGG
TGA.AATCATC
CGTTATCGCT
AGATACTGTA
ATATCAGGCC
1020 1080 1140 1200 1260 1320 1380 1440 1500 1560 1620 1680 1740 1800 1860 1920 1980 2040 2100 2160 2220 2280 2340 2400 2460 2520 2580 2640 2700 2760 2820 2880 2940 2973 INFORMATION FOR SEQ ID NO:1297: SEQUENCE CHARACTERISTICS: LENGTH: 3549 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .3549 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1297 T TTTAGTAG
GCCATI'AACC
CTTCAAGTGG
CCAATCGTTG
\AGGGAGGAAT
CATTAATGAT
AACAACCACA
CT'ITTATTAA
ATAAGAATGA
TCGCTAATAA
GTAAGAGCAA
ACCAAATTTA
AACCGAAGCG
AGTTGATAAT
TAGGGATAAT
AGCGATCAAA
TGAT ITAATC
GATATAGAAG
GC'TITAACC
GI'GTCGCTT
AGGCAAGCT
AATCCTACCA
GACAAAGACA
GAGAAACAAT GACTAACGAA CGCAGCAAI'
TATCAATAAT
CATTTGATCC TAATCAAAAA TTGAGAAAAT CTCGCAGCTA AAAAGAATCA GTATTTTICA ATCTCATTGA
TACAGG'ITCT
120 180 240 300 360 /1/s 922 TCCATAAAGA- GCITI'CAGAA
TCCCATCAAA
ATCATACAAC
CAAGCTTTTIG
GTGTTI'GATG
GATCCTACTG
TCTTCCGATC
GCCACTACCA
AGGGGTAATI'
GCTGACATTG
TCTGTGTTAA
AACAATGGTG
CGAGGCGACA
ATAGCAGGTG
CTCACAGGCT
GAATITCITG
TTCCAAAATG
AATGATCACA
'TTTGGTAATG
TI'AGATAGGG
GTI'GATTIATI
GCTACGAATG
CCTAATTAA
ATCGCTAAAG
AACAAAGAAT
ACAGGCAACT
CGAGAGCGTI'
AAAATGGAAG
AAAGAGGCTA
AGGGAATI'GT
TTTGATGAAT
GCCCTI'AAAG
AACCTTAATG
ACGCAAGCAA
ACGGATAAAG
AGTGGGGTAG
CAAGCTCAAA
AAGAATGGTG
CTTTCTAAA.A
AACAATAACA
AAGGTAAAAG
CAAGCAGCGA
C TTCAGCTA T1'GAAAAGGC
TTGACTCAGA
GACAACCTAG
CTATATGTTG
GCTACTAACA
GCGACCGGCA
GTTCCGCATA
AAGAATATGA
AAAGACATTA
AGCTTGATIGA
CAAAAATCT
ACGATCCGTC
CCCCTATCTC
CAGGAATTAT
AATCTTTGAA
GTGGGGAT'G
TCAAAGAAAC
CCACTGACAT
TTI'CTAAATT
ATCCTAATI'A
TGGGGAGTCA
GTCCTGAAGC
ATGTGGCTAC
GTGAGAAAGG
CACAACGAGC
CACAAAATAA
AGMVI GAAGA.
TTGCTrTGT
GGGAATTGAG
AGGCAAAAAC
CTAATCAA
GCGTTI'CCCA
ATAATCTCGC
GATTGTCCCC
TGGTTGGAAA
ATGACGAGGT
TGGAGAAAGA
CAAAATCTCA
ATAGGGATGC
CTGATAAACT
TCAAAAATGG
GCTCGGTGAA
CAGCTTTGAA
AAAGCGACCT
TTGATAATCT
AGCAAGCGTT
AAAATGAAGA
TAAACGGAAC
ACTTTTCGGA
ATAATGGACT
CAAAAATIGA
GCTrCCTrrr
ACCATGAACC
ATGATAAAGT
AAATTGACAA
ATCAAATGAT
AAAGTGCAAA
GCCACACACG
TGCTAACGCA
ATGTGGGAAG
AAGATTATTC
AGTCTGGCTT
AAGCAAGTGT
ATITGGGACT
TAAAATCAAC
TGATGATAAA
CATAGGAAAC
AGAGAGGCAA
GCTTGATAI'
GCTCAATCAA
ACAAAGC?1'A
CACTCTTGGC
CAAGTITCAAC
TAATGGCATA
TAGGCATGAT
ACTCATTIAAT
GATTAACAAC
ATTGAGTCAA
TGCTAAATTA
TTTCAAAA
TTCTAAAAAA
CTACACTCTC
CACTCTI'CAA
ATACACCAAC
TITAGAAGCA
TATCACTAGT
ACAAGAAGCT
AGCTTAAAC
GAAACAAGCT
TGTAGCGAAA
AGCTAACAGC
AAGAGCAATC
TGAAAATATC
CAAAAATAAG
AGATTTAGGT
TGAATTCAAA
TGAAAATTCC
CAATCAAGCG
AGCCGATCTC
'FTrCAATACT
CCTAGTCGGT
CATCAAGAAA
CGAAAACAGC
CCGACTCGAT
GAAAAGGCAT
CATI'TACGCT
TGATGATCTC
TCTCAACCAG
AGACAAGCTC
AAAAGTGCCT
CATTAATAGC
TGCTCCTTTG
TGATTCGTTC
TGTGCAAT'r
GGAACATGGA
cAGCGTTACC AccCAAAAAA
GAGAAAGCGG
cAAATCCGAT
GAAGCAGAAA
TTITTATCAT
GAACCAGTC
CCGCCTGAAG
GATATGAACA
CAATTADTGA
GAACCTGAAA
TGGAACGCCA
GTGCATATGA
CCTAGTTT
GAAGAGATCC
GACAACTI'GA
GACTCTAAGG
GACAAAAAAC
AAAGATTATG
GGTAGCCTAA
GCCTCCAAGA
GGCTTTAGCA
GTCGTAAGGC
AATAAGCTI'G
'DTCAATAAAG
CAGAAAGATC
AAI'TGGAGA
CAAAAAGATG
GC'ITACGCTC
AACAAGGATI'
GAT1'TCAGCA
ATCAATCCAG
AATGGCAAAA
ATI'AAAGATG
GTATCAGTGG
AAAATT'CT
GGAAAAAATT
AATGGGTTAT
GAGTI'GAATG
ACAGAACCCA
CAAATAGCAA
GATAAAGTTG
ACGATTGATG
AGTAAGGTAG
GCGGTATCAG
AAAGATTCTA
ACTAGTTTGT
AATGTCAAAA
GAGTGGCTCA
TCAGCGTATG
AAGTTTTCCA
TAACCAATA
GTCAAAAATA
AAATTTTrAT
TCCGAGGTT
AGTTTGAG
CGGATCAAAA
AAAATGGAGA
TTGTGI'TAA
CTCATGTCCA
CTAGGGATTT
TGTTAGAT13T
TCCACAATAA
AAGTI'TCAT
CCGT'rGGTTA
AAAATGGCAG
ATCTCTACAA
AAAACAAAGT
GCAAGAAAGA
CVITArTrAGA ATTTAGCTrI'
GGAAAAAAC
AACATGATGG
GTCCTGATAA
AGGTAGCTGT
AGGATT'AGA
TCAAAGNT
CTGTAGCTGA
?I'GAAAAATC
GCAAAAGCGG
AGATTTrOC
AGAATCTTAA
TGAAAGACTT
AGGCAGAAGA
AATGGATTIC
ATAAGGAT
TGATCATCAA
CTAAAGCAAC
CAAAGGAGCA
CTGCACTATA
CTAAAGCAGA
CAAAACTTGG
'TTTATACTCA
GTGGTTTGGG
ATGATCTCAG
ATCTCGGCGG
GGCTTTCAAG
AAGCTAAAGC
CAAAAAAGAA
CAGCGAAATT
ATGGAACAAT
AGCTCGTGAA
ATAAAATI'GG
CCAGGTTGAG
TATrTTCTAT
CTAATACAAA
GAATI'GGGTG
TATGGAAAAT
GTCTGCCAAA
ATiTCATGGGC
GCCTAATGGA
CAAAAAACAA
ACCAGATGTA
GCITGATGAA
TGAGGGAGTC
CGCTCTGTCT
GTTGTATGGA
TAAAAACCAA
TGGGTTAGTC
AGAAGACCAA
GGATTTCATG
GAAAGAAAAA
CGCCCTAGGG
AGTTGCTGAG
AGATAAAGCT
CGTGATGTT
GGGTGTGGGT
CITTAA'TrG
GGATAAACTA
TI'TGAGCAGC
AGCTAAAAAC
TCTAAAGAAA
CAACAAAAAT
GTIGATCAAT
AGGCATCAAA
TAGTA&ATCT
AACACTAAAA
AAAAGTTGAA
CAGCAAGGTA
TCAAAAGATA
GGGTGATITC
ATI'GGCTCAA
CCAATCCGT'r
AGCCACAACT
AAATTTCAAT
AG TTGCTAAA.
TGATGTAGGG
TAAGGTAGGG
ACCTTI'CCCT
G.GAGCAAAAL
AAGTCATI'
TGTTGTGAAT
GGACAATTAC
CAATGAAAAA
TGATAAGATA
ATTCAACCAA
CAATGCCGTA
GGGATCTTAC
AGGTGGTTTC
420 480 540 600 660 720 780 840 900 960 1020 1080 1140 1200 1260 1320 1380 1440 1500 1560 1620 1680 1740 1800 1860 1920 1980 2040 2100, 2160 2220 2280 2340 2400 2460 2520 2580 2640 2700 2760 2820 2880 2940 3000 3060 3120 3180 3240 3300 3360 3420 3480 3540 3549 INFORMATION FOR SEQ ID NO:1298: SEQUENCE CHARACTERISTICS: LENGTH: 672 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) PCTUS 96/09122 iPEAII 18 DEC 1996 923 (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .672 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1298
GCACTAAGT
AATAATAACA
TTCAGTTCGT
GAAAAAAACA
ACTATCAAAA
AAAGATGAAG
AAGCATI'ACG
AATGTAGAAT
ACGACCAACA
GATGATAAGC
TTGAAACACA
TGGCTTCAAT
ATAAAAAACT
ATGGGTCAGC
CTCCCAATGG
ATTTGAAAGA
TrT1rGACTr
ATCCAGTTAT
TACAGATCAA
AACAACGCTG
TATATAATGT
TTAGCACCAT
ATTIGGCGAGA
GAGAGGCTTI'
AAATGACGAT
GCTTGTAT
CAAGAAAGTA
CGTGATTGTC
TGAAAAAATC
TCCTGAAGTG
CTTI'CTATCA
TrTA'rGGCC
AGAGTCTCTC
GTGGAGGAGC
T TFI'GAAAG
AAAGAAGCCA
ACGAATITAG
ACTrTCAAAG
AATAGAGTCC
TTT1GATGAAA AAAGACTr
TGCACGGAG
GTATTCAAT
AAAAAAATCT
TAGCTAAATT
TTCTCTTAAG
AAAAAGAAGC
ATTTIGATAG
AAGTCAATCC
TTAAAAAAAT
AGGGTAAAGA
TTACTITCAA
AAACAAGAGA
CITATGATCC
TTTATACGAT
GATCAACAAT
TCTCG ITGTI'
GCTAGAAAAA
TTITAA~AGCG
CGATATTATC
AAAGGATTI'G
AATGGGATI'G
AAGCATCAGC
AATITTATGC
TAATGATCTI'
TACATGTGAA
120 180 240 300 360 420 480 540 600 660 672 GCGGTATATC TA INFORMATION-FOR SEQ ID NO:1299: SEQUENCE CHARACTERISTICS: LENGTH: 462 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .462 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1299
AATAATGCTA
AAATI'ACTAT
CAAAACACGG
GITTCTAGAG
ATACTCAATG
AGTTCCAAC
ATGAGCCAAA
ACATACTOAG
AAAATAAGAA
TI'GCTTGGTG
ATATAAAAGA
ATCAGCTAAA
ACTATAATGA
CTAATCATAA
TGATGAGCAA
ATTCATCG T
TAAAGGAGTC
TCTI'ATCT
TATTAGTCCT
AATAGAGATC
TAAGAATG T
TCTAGGTATC
TACGGTCCA
T'ITACCACCG
AAAAGTATGA
GGCATGTTTA
GAAGATATGG
CCTAAAGAAA
AATATCAAGT
AATGCGATGT
AACAAI'CTT
ATC'FrAGGGT
AAACGAACT!
ACGCTCCGCT
CGCTAAATAG
CCCTAGAGCA
TTGACGACAT
GGGGCATCA
TCATGTATGG
AT
TTATAAAAT
TAACGCTGAC
CGTGGGGCTI'
AAAAGTGGCC
AAGTTTAGGG
AAATCTTCTC
CTATGCGCCA
INFORMATION FOR SEQ ID NO:1300: SEQUENCE CHARACTERISTICS: LENGTH: 1554 base pairs PC7 96/ -,09122 IPEAIAtS I BDEC '1996.
924 TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1. 1554 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1300 CCTGGTTA AAATAAGGT1'
ATTTTTGAT
AAGTATTTAG
GGTTGGGGGC
AAGATITCTC
TCTATCCCTG
AGCGCGCTAG
CTTGGTGCTA
GATGGCGTT
AAGCATTTTG
CCCAAAACCA
AAITAGACA
ATGAAAAAAT
CGCTCTTTAT
TACCATAAAA
GI'CAAGAGC
AGCTATATCG
AACAACTCCC
GTCCTAAAAC
AAAGACGAAT
GAAAAAACCC
AAAAGCGTGG
GAGAGCGCGA
ATAGGTAATA
GCAGAAGAAA
AAAGCGTTGA
TTTTAAAAGG
TGGTI'ACGAT
AATACAGCTT
AAGAAGAATI'
ATTTTAAAGA
ATTCGCTCAT
CCAAGCAAGA
TTGATGAAGA
AAGAAAGCGT
CCACCCCTTT
TTCTrATCCT
ATTATGAAAA
AITTTGACGC
ACAAGGTGTC
AAGTCAAGCA
CTCTAAAAAA
CCTATACTGC
CAGAGCCTTT
TGCAAAATTT
TTATGGCGTT
GTrATGTAAG
AGTATCAA
AAGTGGTGCT
ACCAATACAT
TAGAAGAATT
ATTTGATT
GATITAGAGTT
ATGGATAAGC
TTCTTTAGAT
AGCCCAAGAA
ACTCACCGAA
CAATCAAGCT
AGTGGCCAAA
ATrGTATAAA
TGAAAGGCTT
GGAGCAATCC
AAATCCTAAT
CCATAGAAAG
TAGTTTAGAA
TI'ATTI'GGAC
TGATITAAAC
GGGGAACGCA
TGAAATCACG
TAAAGATGGT
TGATGAAGCC
GCAAACTTTA
CCCTAATTTT
CACCCTTTT
TTATCAAATC
GCAGCGTITTA
GAAAAAACGC
ACTATAAGGT
CTTATGArITG
ACGATCGCTT
AGCGATAGCG
TACCGCCGCC
GATCAAATCA
TI'ATI'GAGGA
GAGATCAGAA
AATATCTTAA
TTAATCCTTC
AGTCTATCGC
GATGTTAAAA
GATITTAAAA
AAAACTGATI'
AAAGAGGGGA
ATGCAAAAGG
CAAAACTACA
CAAAAACTCA
TITATCGTGG,
AAAAGCGCTC
GCTAAAGAAA
GGAGGCACTA
AACCGCCAGG
ACAGAGCAAA
GTCAATAACA
TATAAGATAG
TGTTTAAACC
AATGGATGCA.
TI'ATTGCCGC
CTGCCAAAGT
TTAAAGACGC
AAGCCATGCA
ATTrCGCTTT
AA.ACGAACGT
AACAAAGCCA
AAAAAATCAG
TITGGGCAAA
TCTCTCTCAA
AGCCCACAAG
TGAAAGAGTT
AATTACAGGA
CGAATGAAAA
CCACGCAAGA
CCGCTCTCAA
TGCAGCTTGT
TTAAAACCCG
AGCTTAAGGA
TCAGTGAACT
AAAAAAAAGG
AT1'TCAATCA
CTAAAACGGA
TCAAATACAT
TGAATTrCAC
AAATCATAGA
cGGAATGATA GGGACAGAT1'
CTATGCTGAG
TTTAGAAAAA
AGA TTAGGG
TTTICAAAAA
TrACCGCCC
CGCTCTAT'C
ATrGCAAGAC
TGAAGAAGAG
cTTTAAAACA GGAGGAATAC
TTTTAAAAGC
AGCCTTAAGG
~TTTGAAAAA
GCCCC?1'GAA cTCTcAAAT'r
TCTGACTCAA
TTTAAAGGG
TAACCAAGAA
GTTTGTAACC
CCCCTTAGT
171TGAT
TCAA
120 180 240 300 360 420 480 540 600, 660 720 780 840 900 960 1020 1080 1140 1200 1260 1320 1380 1440 1500 1554 INFORMATION FOR SEQ ID NO:1301: SEQUENCE CHARACTERISTICS: LENGTH: 471 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: PCT/US 96/09122 IPEANS 18IEC 1996 925 NAME/KEY: miSc_feature (Bi) LOCATION .471 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1301
AAAGGTAAGC
TCAAACTCTT
TTIGGGCTTTT
GTG ITAGCGT
CTI'ATAAATI'
GCTGCCT1'AG TrTCTAGCCT
TCATACATGT
TAGGCCTAT
GTTGTAAGGC
'TrTCCTT
TAGTCATAGG
CAGGGCTATC
TGTC'FTTCTC
'FITCT ?r'rG
CCCCAAACTG
TTACTATT
CTGTTG'FTGC
TGAAGAAGTC
GTCTAGATCT
AGTATGGCTI'
AGCTI'GTCT
GCTCACCCTA
CTCATGCAAA
TCAGACTTAC
TITTCTI'TCT
TCTGGCTC T
GGGTTAGAAG
TCAAGCTCCC
TCCArrrITrr
ACCATGCTGA
GCCCCAAAAT
TAGAGTCGCT
TTGAAAGGCG
TTGAAGCTGT
AATI'CTGTGT
CACTGCTCCT
TAAGAACGAT
TCAAGTATT
CTGAGCCTT
AATrTTGCTrT TCG EMI I
TTCITI'GAGC
CTTAGAAGAG
CTT GGAAT
TGCATCCACT
GATATACCCA
G
120 180 240 300 360 420 471 INFORMATION FOR SEQ ID NO:1302: SEQUENCE CHARACTERISTICS: LENGTH: 618 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1 .618 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1302
GGGCTTTTGA
TI'AAAGCCI'
'ITTAATTI'CA
GCTATGCCTA
GAGTCCTI'AA
'FrAGCCAGAA TTAGATrAA
GAATTGAGCG
GTGGTCATGC
TCACACAATT
AGCCTI'TAGA
ATGAAAAAGC
GCGTGTTGGA
AAGCTAAGCA
AAGATCAAGG,
GCTrGTTGCA
AAAACCAAGC
TI'TAGTCAA
TCAAAGATAA
TAAGCGCGCT
AGAAACCGAA
CAAAITGAI'
TITI'GTCT'A.
CATI!AAAGAA
CATTAACGAT
AAGAACGCCC
TATCCATGAT
AAAAC'TITI
TTATGACACG
ATCAAGGCGT
GCTI'ATATCC
ATGGGGAAAG
GCCACGAGCG
TI'GTCCGGCG
TTATTGTTAC
GATGCGATTA
CCCAA'ITTGG
TTGCAAGCTI'
CCCCTAGAAG
GTAACAAAGA
CCCAAGTGGA
CGACGCATTT
TTTTAGAGCG
GTCAAAGGCA
TGGATGAGCC
AAGATGAGAT
TTGCCAGGCA
CCACGCCAAT
CGATCTGGCA
TATI'TACCC
ATATTATGCG
GAATCTGTTC
CTTGGATTA
GATGGTACTT
TACGAGTGCG
GAAAAAACGA
CTCCACGCAT
CGCTATGACT
TGATGATAAG
120 180 240 300 360 420 480 540 600 618 CTTGTGGTGT ATGCGTT(3 INFORMATION FOR SEQ ID NO:1303: Ci) SEQUENCE CHARACTERISTICS: LENGTH: 339 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO PCT/U'3 96/ 0 912a2a IPEAtJS 18DEC 1996 926 (vi) ORIGINAL SOURCE: ORGANI5-M: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1 .339 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1303
AAAGAAGCCG
GTAGGGGGGC
AAGAAAAATT
GCCCCTTTTG
~TTTCCAAT
AAAACGATGA
TGCAACAATT
GTTATAGCT
TTAACGCCCT
AAAGCAAT
ccAAAGOCCA
AAAGCATATC
TGGCATTGAC
GTGGTCGGCT
TTGAAAGGG
ACCCGTITA
CTTGATCGCC
GCTAAGCACT
GAGCATAACA
ATTGGCTrAT
GCGTATTTAA
ATGGGATI'AA
CCITACGAC
TTGTAGCGGT
TGTTTGGAT
CCATI'ATGAT
TGGATGAGCA
TCGGCGTGTG
ATCCACCAAT
TTGGGATTTr CTATTT1AGGG TrTTAGAAAC
GTATATCAAT
INFORMATION FOR SEQ ID NO:1304: SEQUENCE CHARACTERISTICS: LENGTH: 468 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .468 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1304 CACAACAAGA CACGAATGAA TACTACACCC CAAGCGTTTT TCTATGGGGA GCTTGATGA CCTTGCGCGT TAGTGAT1'rC CGAAAGGGGA TT1TAATGAA ATCGCCTI'IG ATAAAACCGG CCGCAAAACG GGCATI'CTAA CCACGCACCC GATCGCTTTA
AAGAGCGAAA
ATTCATCGCC
GTGGATTTAT
TGTGCCTTTA
AGGAGTGCAT
CACTTTGACT
AGAAGAAGTT
TCCATTCAAA
CGGAGGAAAT
TrrAATGATCG
AGGGGGCTTG
GGGTATL'TTG
GTTTTAGAGG
AAAGGCGTI'I
TGCATTACGC
AAGCATGCGA
TTATCACTAA
CTGTATTACC
TGGCTI'rAAT
GAGGCGTGG
TGCTTACCCA
TrAAAGTGGT
TTCTTGCTCG
AGAAATGT
ATIT~TACGC
GCCCTTGTTT
GGTGAGCTGT
AGCGGCGAGC
AACTAAAAGC
GGATATrIGTG
CAGCTTTTAT
120 180 240 300 360 420 468 INFORMATION FOR SEQ ID NO:130S: Wi SEQUENCE CHARACTERISTICS: LENGTH: 297 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: PDP 9b/09122a IPLNUS60-C1996 927 ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .297 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1305
CGCTCCACTC
AAGCAAAGCG
GCGATCGCTA
AAGGCGGTr
GGCGATGTGG
TAGCGAGCGC
CGGACATI GT
AAAAAACTAA
'ITATCGTGCT
GGGTI'ACGCT
TGATGTGGG
GATCACTAAT
AAGCA'TA T
AGGGCTAG
T'rrAGACTI'A
ATI'GGCATGG
GACTCCTTAA
TGGCAAAATA
GGGGTAGCGA
GCCAATI'CCA
GGAAAGGATC
GCTCTTTAGT
TCTTGTrCGC
GCTI'GTGGGA
TGCGCACGAT
AGAATTGAGC
CAAAGTITTA
TITGCGGGATT
AGCGGTCTTr
GAGGGCT
120 180 240 297 INFORMATION FOR SEQ ID NO:1306: SEQUENCE CHARACTERISTICS: LENGTH: 1083 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .1083 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1306
CACCAATCTT
GGT TTTGAAA
ATTCAAGGGC
AGCCGT'rIAG
AC'ITTCACCA
CAAGCCCTTA
CAACACATGA
AAAACGCTCT
AACGGCAT0A
CAAAACGCGC
AAGATTTITAC.
ATGGTAGATG
?1'CACGCACC
GGGGCTGATA
AAA'ITAGAGA
AGCCATAACC
GTGATTTGTA
CWAGCCCTT
TGG
TTAAAAGAGC
AAAGCAT ?I'
CTTITATTGAT
CGTATTTGAT
ATAAAGCGAG
TCCCCCCCTr
ATCTTTTAAA
GCAAACAGCT
TGGATTTGAG
TCAAAAAAGA
AAGATAATGA
AGTATCAAGA
ATAATTTGTG
?I TCTAACAT
CCAACTACCG
AACACCGCCA
AAGAATACCC
TI'AAAGAAGG
GTTTGAACCA AGAAGAAAAG AGACAAT'ITG AACGGAGCGC TITTAGCGGGA GCTGGGAGCG TGGCGCTTGT GGCGTGCCTA TAAAGAAATG CAAGAAAGGG GCTTTGCACT ?ITCCATCGTT AAGGGCGTGC GATIT1'TCGG CAAAAITTCA AA'rrrCAGGG CGTGCAAGAT AGCGAATGTT CAATTTAGTG GAT1TTGACG AAAACTCGCC AAAGAGACCA CACGAACGCC CTGCAACTGG CGTGGTGGGC GATGACGATC TTTAAATT TCCAAGCAT1' C TCTAGCGCT GAAATCTTAG CATTAAAACG CTTCAAAGTr CACGCAAAA GAAGAGAGCC GCGAGATrT AGAAAATATc GGCGAGT1'I'
AAAAAATTGC
GTAAGACTAA
GCGAAAACAC
CTrTGAAATT
TGGTTTGCT
TGCTAGATAG
CGAGCATTTC
ACAAAGCGTA
ATTTGCTTTG
GCGAACGCTA
lITTTAAA
AGAGCATTTA
'ITAAAGGGGC
CGTGCGCTAA
TCAAAGGTI'C
TGGATGTGGC
GCTATTTT~IGT
TAGAATAATG
CCCATOCCAC
GACTTTAACG
ITTAACGCTC
GTI'GAAAAAC
G TT1AAGG
CGATGAAGTG
TCAAATCAAA
TGAGCTI'TAT
T1TCAGCCTI'
CCATTACATT
ACAATrTGAGT
TGGGTTTAGG
TAAAATAGTG
TCCCTGATC
GCACAAAAGC
TTATCAGATT
ATCGTTTAAA
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1083 INFORMATION FOR SEQ ID NO:1307: SEQUENCE CHARACTERISTICS: LENGTH: 2526 base pairs STRANDEDNESS: double PUTUS 96/0912.2 IPENS .80EC 1996 928 TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE- NAME/KEY: misc-feature LOCATION 1 .2526 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1307 TrGTGCTGA ATGAAGAGCA AAAGAAACCC CCCTAAAGGG CAGACGArrA GTAAAATCAA AAAAACCTTI' ATATCGCGCT AGTI'GTrAC TAGGGCATAA ACCACCAATA ACGAAACGCC AATI'AGACT TGCCTGATTI' GTGGATGCGA TGATGCAAAA TrGCAI-ITGT TTGATAAGAT GTGATTAAAT TCAAAGAAAA GCTTCTAAAG AAAACGCCAG CAAGATGCGG ATTTGTATTA TACAAAAAGT C TTTATTC TTTGAAGCCC TI'TCGCCTI'I CGCTTAGCGT CTAAAITGTT CAAAAAAGTG CGAACGCCCA ACTTACAAGC AGGCTTI'GGA AACGCTTI'AA TGGCTTTGGA GAGCCT'A AATTAGCCAG CCCATCAAGC CCACTATAAA TGGAACACGC AATMTI'TGA GCTCCTT'ITA AGGTTAGA CTTTI'AGAI'r CTGACACGCA CGTITGATGG CGATAGCGGA CGTCTAAAAA AAGCCCTITTC C TITTGCATI' ATAATGTGGG TTCCATTIT1' TAAGGGCTTT GTI'TAGCCT CGCATTI'CAC AAT1TTTTATA GTCATGAI'T GCTTAITTGA ATTACCGCAC CTCCC'rTI'1' ATTACGCGCT ATGGTGCAAT C'T1'rGGGAA ITITATGAAA TCGTCTCGTA CTTAGATrr CGCATAAAT CATTTCTACA CTTACATGGG GAGCAAAAAA TCGCCAGT'I GCGCTAGTGA GTTTGTTI'CA ATTGATGGGC 'rrAAGGATAA GCGCAAAATA A'rrACAATAA AATAATGAAA ATATCCGT'A TCAGCGCTAA ACCATT TTTGAAATTG ACACCAATCT
TTAGAA
AAATTCATTA
CATTCATTCT
AAGCTCTAAA
TGGAATAT1'G
AAAAGAAAAT
TAACGACACC
AATCGGCAAA
ACCGAGCCTT
CGCTTCTITC
GGATTI'TAAT
CGTGAGCGCG
TCATTATCTA
CTACGCI'AC
AATGCACCCT
TTTGATGTTI'
AGATGAGC'T
GCArI'TGCAG
ATTGGTGAGT
CCATACGCAA
CCCTATGTITT
AGGTAAAAGG
CTCTAAAGAA
AAAGGATTITA
TAAAAACGCG
CTrGATTTAT
CCATTTGAAT
CCATGAAGAC
TTCTAGCCCC
CAATTGGGAT
AGAAGCGGTG,
TTTAAAAAAA
TITACGATGCG
CAGTITGGGAT
AT'rrATGGTC
AGAAAGGGGC
AGGCCAGTAT
CGAGGCGCGT
CGCCGCTITA
CGC TTAGGG
AGCCATTAAA
TTTAAAGAG
GAAGAAAAAG
AAAATCCCCT
GAG7ITI=CA
CITTCACTCA
AAACAAACTT
AATAACGCAG
GACTCTTTGA,
TTGTATGAGC
TCGCAAGGGA
GGGGCGTTGG
ATTGATGCGT
AAAATTGTAA
GCACTCAAAT
AATTCCAACG
AAAGATGAAA
GCTTTAGGGC
CATTATTTGC
TTGAAAATGG
GAAGACACGC
TI'AGACAAAG
GATTTTATCT
ACCTTAGGCG
GAGGGGGCAA
CTCAAGGGGT
TI'GTCTTTAA
GCGCAATTGG
TCTGCGGATI'
ACCACGGAGT
ACGCAAAAAG
ATIGGACTGGC
TI'CGCTAAAG
ATGCTCCCTA
AGCATCCGCC
CAAACCATGC
AATGATCTGG
GAAGCCCCTA
GAAAAAGCGA
TTAAAAATCC
TGGCTAGAGC
TTIGTIGTATC
ACCTCTGA?1' CG TIGAACC
GGGGCGAAAA
CTTTGAAGCA
AACAGCTTCT
TCGCGCTCAT
CTI'TACAAAC
AAGCCGAAGG
AAAGAAACGA
AAGGGCAAAA
TTGCGAGCCA
ATITGITI'GA
TAG'rTACGGC
GAGACACTT
CCTACTACGC
CCF1'TTAAA
CGAACGCTI'A
T TTGCAGGC
ACAACTACCC
GCGATACCCT
TATTAGCCAA
AAAGGGCCAA
ACCGCT1'GCT
TGATTGAAGA.
GCCTTGCTITT
TGAAAGAAT'
AAAATAGCCC
AAAAI'ACCA
ATTTGAGCGC
TITTAAGAGA
CTTITACTCTC
TCAAAAACGC
AGAGCAAGGA
AAGATCTCAT
ACACTTTAAG
AAGGGCCCAT
ATCATCAAGA
ACGATI'GGTT
GCGCGTI'GTA
TAGCGGGTTT
TTGGGAAATT
AAAGAAAGGG
'rrTCGTCGCC
AAGAAGAAAA
CAAAAACGAA
GGCTITGGAG
ACACAATAAA
TGTGGCTTTG
TAATACCGCC
GCAAATAGAA
TGAAAGCCAA
AGATGAAGCC
TAATCTAGGG
T1'CCAGTATC
TI'ATCATI'TG
GTATAAAGAT
TGGAGAGTAT
GCCTAATGCG
CAAGCAATTG
CCGTTTGGGT
TAAAGATITA
TAAAGCGAGC
CTCTTTITAC
AGAGCG7I
GITTTTATIAC
GGGGCTGTTT
TAAAAGGGGG
AGAAAAGAAG
CAATAACGCG
CAAAGCTTAT
GGTTTrI'GCG
AATCACCGAG
TI'CGCTCATC
CCCTAAAAAG
TAAAAAATTG
CTCTAATATI'
CAT1'TACACC
?I'TAGGGCGT
AAGM'ITGTTA
GGAAAATTTA
TCAAAACT'rA
AACCTATATC
AGACGATCCG
AGACI'GAAA
TATTTTGAT
GGGCGAGTT
120 180 240 300 360 420 480 540 600 660 720, 780 840 900 960 1020 1080 1140 1200 1260 1320 1380 1440 1500 1560 1620 1680 1740 1800 1860 1920 1980 2040 2100 2160 2220 2280 2340 2400 2460 2520 2526 INFORMATION FOR SEQ ID NO:1308: SEQUENCE CHARACTERISTICS: PCT'US 9 6/ 019I1 a IPENIUS 18 DEC 1996 929 (A).LENGTH: 1068 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .1068 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1308
AAGGTI'ACTA
CGCTGGATCA
GAAAAAATGA
TCCGTAGAAA
ATCACTAGAG
GGGGGCATGG
TTGGTCGCTA
ACCGTTAA.TG
TTAGGTTATA
ATrI'ATTCTA
GATAACATGA
GATGAAGTGG
GTGGATAGGC
GAAGTGGATT1
AAAAAAGCCG
TCGCACCATT
ATTGTAGCCA
AGGCGCTTTA
CTACCATGAT
AACAATACAA
GCGATGTTGA
AAGATITTGCA
AAGCGAGCAA
TCTTAAACGA
CTI'AGCGGT
ATTACTTAGC
GCGTAGGCAC
AAGACATTGT
AATAWI'CTIT
A?1'CCATIT1
GCATGGAAAA
TCACCATAGA
AAAATCTCTT
TAGACCAAGC
ATAATGAAGT
GTGAGGGCTT
AAAAGCAATC
AAAAAAAGTC
GCTGCAAAAC
AGAAAAAACC
AAGGATCTTA
TGGCAAGATC
GGCTTTGAAC
CCATAGGGAT
GATCACTGCG
TI'ATGGCACT
AGAGCATAAA
AATTGATGAA
TTACAACAAG
CGAAAAAAAC
TGGCGTGGAT
CTTGAAAGCG
GGTGAI'GTA
AITGGAAAAA
CTAGCCATCA
GCTTTTGAAG,
CTITAGAAG
AAGATGCGCC
GCTGAAATGA
GCTATGAAAG
TCTAAAGAAA
AGCGTGCGAG
AATAATGAAT
GTGCAAAAAT
GCGAGAACTC
GCTGATGAAG
CGCGCGATTT
AATI'TATACA
AATTIACCTCT
GATGAATTTA
TCATCGGCAC
ACGCCTTAGA
AATTAAAAAA
lTTI'ACCAGA ArrITrGATGT
AAACCGGAGA
GCGAGAGCGT
TGGdAGCCGTT
ATGATGATGA
TTGGCTTI'GA
CCCATGCGTT
CTI'TAATCAT
TCGCTAAAAG
TAATCACTGA
AAATTGAAAA
TTATTGA
CCGGCCGT
AAGAGGCG
TAGAAACGAT
GCcTACTTAT
ACGAGTGCGA
AAGCTTTGCT
GCAACTCT
GGGTAAGACT
GTATGTGGTA
GTATCAATC
GCGCTTAGAA
TTATCTAAGG
CGCCATTGT'
TI'CAGGGCCT
CATGCAAGTG
AGAGGGGATT
CGCCGCCCTA
TAAAGATTAT
GTCTGAGGGG
120 180 240 300 360 420 480 540' 600 660 720 780 840 900 960 1020 1068 ACACCAGGCT TI!AGAGGCTA INFORMATION FOR SEQ ID NO:1309: SEQUENCE CHARACTERISTICS: LENGTH: 1095 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1 .1095 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1309 AAGCTTTITC TAAAACCCCT AAAAGAAACG AGCCI'GCCC TTGTGGGAGT GGCAAAAAT ATAAAGATTG TTGCGCTAA.A AGCGGGCCTA AAAAGGGCT1' ATTTGCCAAA TAGATCCTI'A 'G TM 1 S 96/0912.2 IPENLJS' 18 DEC 1996
ATCTTICC.TTATCAAGC!G
ACTGC TrTGT TrAGCCFIT1' GCGATCATGA ACGGCATGAG TTAACGCTCT ATACCACAAG AAAAAGTTCC CTAATITGCT GCGCAFI'CCA TGAATGGCGG AATGAAGTTI TAAATGACGC TTTAAMTTGA TCGTGGGGAA GCCGATTTGT TrFTCACCGA CGC TI'ACTA TCAAAGGCGA TATGCGAGCC TrCAAGCTAT GTGCATGTCT ATI'CTAAAAC ACAATCAACC ACCATGGCAT TCGGCGATGG AATTGGAAAA GCGTCTTTIGA ATATCATCAG GCCCTACTCT TrAGCATGGG GGTAATATCA TrAGT
TTATI'IGCGT
TGGCGTGGCG
TAALGGAATI'I
CCCTTATGGG
TrTTrAGCCCC
CGTGGTGTT
cTTAAAAAAC
AAGCTTGAGA
ATAGAGCCA
'rrrTGATTCA
AAGCGCGATC
GCCCATGAAG
AGGCATITGAA
AAGAGCGTA
CTCGCTTTTA
GAGCAGTCAA
TTTGATAAAA
GTTGGCGTGA
GAAAAAAAGC
ATCAGCGAAG
TATT1'GCAAA
GGGGTTGATT
ATrAATGAAA TACAGC ITGA
ACAGGTCTCA
GGGCTAAAAT
AGGAGATTAC
GATATTGAAA
GGGTGGTGGC!
TTCATTGTGC
ATGGTGGTGA
AAAGAAATCC
GCCAGCCTT
TGGTTTTAAT
TTT'ITGTGAT
AAGTGGTrCA
CCCAAAGTCC
TTCTAAAGA
ACGATCTCTT
ATTTAGATCT
CGCTCTCCCC
CCTATGACAT
CCTrAGGGCT
AATTACGCAA
AACAAAACGG
TCATGCTCAT
TGAACAGGCG
AAA.AAACCTI'
CATIAGTATC
TGTGGCTATG
GAACTACCCC
AGCTTTAGAA
GATTAAAAGC
AAGGCACATC
CAAAAACCCT
CAATCAAAAA
CATCATGAAA
GAGCTACATG
TTATGATGGG
CGCIWITAAAA
GAATTITC
TATI'ITAATG
TAAAGAAATC
TTTAT'TG
180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1095 INFORMATION FOR SEQ ID NO:1310: SEQUENCE CHARACTERISTICS: LENGTH: 1062 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: H-elicobacter pyl~ori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .1062 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1310
AGAGGCGTGA
TTCAGGATGT
T-I71rTAGAAA AAAGA'TrGA
AAAATTAAAG
AAGAGTGAAA
GCCAAGCAAC
ACGATTGCGA
GAACTTGGGG
CAATTAAGGG
TTAGAAGACA
F1'AGGGCCTA
GCGCAAAAAA
GATGTGGCTA
AATTACGATA
TCTAAACTCA
AACATTTTAA
CCTATTGAAA
GCATTAAAGA
TTCTAAACT
TCTACAATl'
ACGATCTGAT
AATTACACGA
CCTTGCACGC
ACACTAAAGA
CCAACATGGC
GGCTGTATAT
GGCGAAGCGG
ATCTGTTACG
AAGACGGCGA
AAGTGGAGAA
ATGAGCAACG
TTAGCGCTAA
AAGCCTGA
AAGAAGATTT
TATTTGTGGC
AGAGAGCCAA
TTCAGGC.ATG
AGA.AGTGGTG
CTATAAGAGT
TAAGGGTCAG
TTTACTCAAA
AGCTGAAATC
AGGCAGGGGC
CATTGGCACT
GCGTCAAGGC
CATITTTTGGG
ACACATTGAA
CTTGCATTI'
AACAAGCGTG
AATCGCTGAA
CCATCAAAAC
TAACGCTAGC
TGAAAAACTC
ACCTI!AGCCG
ACAGGCACGG
TCCATCCCTA
GAAAAAGAAA
CCCGTITAG
AAAGAGCGCA
ATCAAAGACG
GT1'GATATTA
GAAAGGCATG
GATCCGGGAG
AGCGATAGGA
TrCAAGCTCG
GACAGCCGTA
TATAATCTTA
AACAGAGAAT
CTGTCTGAAG
GTTGAATTAG
AAAAGCGGAT
ATATTACI'T
CTCAAACCGA
CTAATCTAGC
AATTTGACGC
TCGGCACGGC
TCCCTCACAC
CCGGGCTTAA
AGCTCACTGA
AGAGCCGTAG
TGAGTCAGTr
CTAAGGGGGT
TTACAAGAGC
AGCATTTGTT
GAGATGAATT
ACGCGCTCAA
AGGAAC TTTT
AAGATTTAGA
TA
CCAAAATI'AT
AGCCACAGAA
GATCAAGCGA
TGTGATCCTT
TAGCATTGAA
CGTTAAAC
AGGGGCGGTr
TGAAGTTAAA
GATTGACA.AT
TrATTGAGC
GATGGAAAAA
GGTGGAAAAC
AGAATACGAT
ATTAGACATC
TCAAATCTT
AGGGcTI'AAA
AAAAGCCTCC
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1062 INFORMATION FOR SEQ ID NO:1311: SEQUENCE CHARACTERISTICS: A ,C,"ut/Uls 96/0912.2 PEA/S ia DEC 996 931.
LENGTH: 321 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .321 SEQUENCE DESCRIPTION: SEQ ID NO:1311
ATGCAGAAGT
TTAGCAGCGA
GATCAGTI'AG
ACCGATCACT
TTAGAGCCTA
AAAACGGTITG
TTTTCTCTCG
TTGATATTGA
TGAGCCTGAG
TAAAAGATCT
AGCCTAAGGG
AAATCGGAAG
TTTI'AGAAGG
TGAAGTAACA
CGATAAGCT
TAACGATTTG
CAAAGAAGAT
TGGGCGTTGC
GAAGCTCAAG
TTAGAAAAAG
CATGAAAAAA
AGTCCTAACT
CCTTITATTT
CTAATAGCAT
CGGTGGATAG
TCAAACATTT
TGGGAGGTAA
TGTGAGCGCT
TAAATTAAGC
GGGGCGCAAT
GCGCTI'GATI'
TAAGGATATG
INFORMATION FOR SEQ ID NO:1312: SEQUENCE CHARACTERISTICS: LENGTH: 825 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .825 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1312
AAAAACCAAA
AAATCTATTA
TTTGAACCCC
TCTAACGACA
CACACCAAAC
AAAGAAAGGC
GAAAAAACCG
AATGAAAAAG
ACTAAAGAAA
TTAGCCACAG
GAGTI'AAAAA
ACCAAGCTAA
AAAACAGAAT
GACAAAGAAA
TAC'ITCAAAT
CAGATCTITAA
TTAGAAAACT
CCCAAGAAAA
CGACTGAAAC
TAGAAAGAGA
AATTACAAAA
CCGATrGGCT
AAACAGAGCT
AAAAAGAAAA
ACTCTAAGCA
AAACAGATAA
TAAATAACAA
ACCTAACTAA
CCCACTGCI'
AGATCG~CCTT
CTCTCATI'
CCCAAAAGAC
CACCGAACTA
AAATAAAAAC
ACAAGTGAAT
AAGAGAAAAA
GACTGAAAAA
CCTAACTAAA
AGTTrAGAA
AACAGATCTG
GATTACTGGG
AGAAAGCAGA
CCACCCCCCC
AAAAAA'ITAG
ATAG'ITATAG
GC TI'AAAAT G ITGAAGAAA
CTAACTGCAG
GAGTTAAAAA
GAAAATCTAA
AATAAAGTGC
GAAAAAACCG
AATGAAAAAG
ACTGAAAAAA
TTAGCCACAG
CAAAGAAAAC
CCAATAATGA
AAGATCTTAA
GTAATTIv1GTT CCACCAAT1'1
ATAAAGCGCT
ACAAAGAAAA
ACTCTAAGCA
CCAAAGACAG
TAACCACAGA
AATCACAAAA
CCGATCTGAC
ATCAAAGGCT
AAAAAGAAAG
CTAAC
AGAGCTTTA
ATTAGAAGAC
TGGAAAATCC
CCACGAGAAA
AACCACAGAA
CCTAACTAAA
AGTITTTAGAA
AGAAAACCTA
AAAAGAAAGG
ACAAGTGAAT
CAACGAAAAC
AACCACAGAA
GTTAGCCGCA
120 180 240 300 360 420 480 540 600 660 720 780 825 ;01 v r% f% I I POT/US 9 09)12a.2.
I PEAIUS 180JE C 1996 932 INFORMATION FOR SEQ ID NO:1313: SEQUENCE CHARACTERISTICS: LENGTH: 390 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii)-HYPOTHETICAL:
NO
(iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .390 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1313
GCGCTTTCTA
CATCGTTTTI'
TCTCGCTCAT
GCTTTATT
AGCCTTTCTT
AATAAGCGTG
TTAGTGAGCT
ATTGTTTGAG
CTAGAAACCC
TAGTGAGCGC
C'TTrAGTCAG
TI'TCTGTIGT
TGTTI'TCTTI'
TGTTATTGTT
C!I'1GTCAGTT
ATGCGCATCT
GGTAAC'ITGG
CTCGGTGATI
CAATICTCTT
AGCTAAAATG
TTIGCCATAAT
AGGCGI'GGT
TGCAATCGCG
TGGTTGAGCT
TTATGGGTTA
TITTCTI'CAG,
TCTTTTTCCG
TTTCTTTCTC
CTCGCTCTI'G
TGTICGTI'TTC
GCTCGGTGTI
TCAGCCGATC
TTTTCAGTTC
TAAATTGGTG
TTCGAGACTA
GGTGGTTAGT
TTCTCTITTTT
TCTGGCTGCT
TGCTTTTTCT
120 180 240,, 300 360 390 INFORMATION FOR SEQ ID NO:1314: Wi SEQUENCE CHARACTERISTICS: LENGTH: 981 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .981 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1314
ATGGGAACGC
CGCATCAGTG
GCAGAAACTA
TTCATAACAA
T'rATCTGTAA
AAGCTCACTA
ACACGCTITAT
AAAGAAAGGC
TCATI'GAAAA
AGTTAGAAGA
GCGAGTTA.AA
AAGACAAGCT
AAATCAGCGG
AAGAAAAAGC
TAGCAGCCAG
TAAAAAGAGA
ATGGTTTGGC
CGAAAACACC
AGACGCTAAC
AACCAAAGAA
GTTAGAACAC
AGAACTGAAA
AGATCGGCTG
AAACACCGAG
TTCTCTCAAA
GAATTGITAA
GATCAATTAC
AACACCGAGT
TCTAACGATC
ACGGAAAAAG
ACTGAAGAAA
CTAACCCATA
TCAGAGAAGA
GAGAAAGAGA
GGCAAAAAAA
TATTCGCAGA
AAT1TATGGCA
ACATITTAGC
AAAGAGAAT~T
AAATCACCGA
ATTAGAAGCT
ATACTTAGCT
CGACAAGI'A
AAACGAAAGC
AAACAATAAC
TAAAGAAAAC
GACAACAGAA
GCTGACTAAA
"N I I I r 71 C-1 f PCT/US 96/09122 IPEA/US 18 D EC 1996 GAAAATAAAG .CACTAACCAC AATGAGCGAG ATAGTCTCGA GAAAAACGAT GCACCAA TIT TTAGAAAGCG CTCAAAAAAG AACTCTAATG TCCAATTAGC GAGCGAGAAA TCGCACGC7I' TrACACAACA GGCG rTTACC GAAGAAGAGA ACATCGCCCT
CGAAAACGAC
ACAAGAGCGA
AGAGAAAGAA
CTTGGAAAAC
ACAAGCTAAA
GAAGAGCTA
GAGCGCAAAC
CAAAGAGAGG
AAGCTCAACC
GCGCGATTGC
AACCAACGCC
ACTAACAATC
GAAAAAATAG
GAGGGTATGG
GAGGATTTAA
GTTGATGGCT
ACCAAGTTAC CGCGCTCACT AAGATGCGCA TGGGTTTCTA TAACTGACAA GCTCAAACAA AATTACGGCA AGCTF1'AGAA CCATAGAGAA AAGCGAGCTG AAGCCAAAAG CGATCTGGAC AACGCCAAAA CCGAAAA ITA.
TGAACGAGCA GCTCTCCAAA TI'GCAACCAC AAAAACCACA A INFORMATION FOR SEQ ID NO:1315: SEQUENCE CHARACTERISTICS: LENGTH: 279 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (geriomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .279 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1315
TFI'AAAACCA
AAAGGATATA
?1'ATTGAGCG
TCTTCAAAAG
CCTTATTCTT
TTGAACGAAA
AAATGAAAAC
GTTGTTCTAG
ACGCTI'CTAC
CTAACTTAAA
CGATITTTAAA
AAT1'AAAAAT
C'TTTGATGCT
CAAAAAAGAA
CCATTGGGAT
TTAAACGGAT
GGTATI'ATGA
CAGCG TrCG
GCGCAATACA
TCTACATTC
TGACAAAAAT TI"IACAAAAC TCGGCACACT CGGTGCGITG CTTGTCTCCC TAAAGACCAT TTCCTAAGGG CTTI'TGAC 120 180 240 279 INFORMATION FOR SEQ ID NO:1316: SEQUENCE CHARACTERISTICS: LENGTH: 909 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:.NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc-feature LOCATION .909 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1316 *AGCTTAAATA AGGGTCTGGC ATTGTTTA GTCAAAAAAA TAGGCGTGGT AATAATGAT' POT/US 9 6/ 09122Z IPEAIUS L8 DEC 1996 TTAGTCTGCT -!TITAGCTI'G GAGCAAGAAA ATGACGGCTC AGCGAAACGA ?TTIW1WTTACA TT~CCAACTGA CTAAAGATGA AATGAGCCAA GCGATAATAG AATGAAGACA ACGCTAATAA ACAAAAAACC CAAAACTCAT GATA'ITATCA TGAGTAAAGA AAGCGT1.VI'T TAAAAGATCA GACACTAAAA CGCAAATCGC AATAACGGTA GC'FIGAGTTr GATAATGTTT1 ATACGATAGA ATGGTGTI'AA AAAAGCATIC GATTI'GGA'IT TrAAAAAAGA
AAGGAAAGT
CTCGCAAGAG
TAAACGCCCC
AAACATGGTG
AGACAATITCT
TGAAAAAAAC
TAGTCAAAAA
TGAATATTCC
AGGGGATCAA
AAACGATAAA
GCAAATTAAG
AAGGCCTTrT
GAATAAGGCT
AACCGATAAA
GCGCTII'AAG
AGCTI'TATCA
AGCTATGTGG
TATCAGCCTA
'rTrAACCCTG
CTACTCTCAT
AATCCGT1'CC
CAACAAGATI'
TGGTTGATAG
GATCGCCAGA
GGCAAAAT Tr
TATGAATCGT
'ITAGATACTA
TTAGACAGCC
AGCGATACGG
AAATGCAAAA
ATTCGGATI'A
TAGAGGAAAG
AAAATI'CCGT
ACCCAAACGA
ITTTACAACC
TCTACCCCCT
AAATCCAATC
TCCAAACTTT
CTTCGTATGT
TITTGTTAGA
TGGAGATITC
AGCATAAAGC
AACTCITTTTT
AAAAGCCCAA
TGAAGTC'T'1'
AA.ACGCTTT
GATI
T
TTACTIG
TCCCAATAAC
CAAAAGAAAA
AAAAAATGGG
CAAAGCCTTG
CACTITI'AAT
TTATACCACC
AAAAAAGAGC
AAAGTGTCAA
CATCAGTAIT
AGAATGTCTI'
120 180 240 300 360 420 480 540 600 660 720 780 840 900 909 INFORMATION FOR SEQ ID NO:1317: SEQUENCE CHARACTERISTICS: LENGTH: 363 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1 .363 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1317
GCATGGI'AA
GGAGTGGTGT
ATI!GAAAAGA
CTrCAGATA
GAAGCTITCA
GATACGGATA
GAG
AAAGTAGGGT
GGGGGAAATC
CCCAAACCAA
TGGATTATAG
AGGGATAG
AAGTTTATGT
TTAATGAAA
CTTGCCTAAG
AGATGAAAAA
CTTGTCCTCA
AATAGAGATT
GCTI'CTAAGA
CGCCTTGCTG
TGGGCAAAAG
A'rTTTAGTGT
GCCAGACAAA
AAGGCTGGTG
ATCACTAAGA
'ITGCGC'ITAT
ATTGCTCAAA
GTGGGATGAG
ACGCC'ITAGA
AGCTAAAGGC
AGCATGTCGC
TTTGGTGTTG
AGAGATGCGG
CGATATATI'G
GAAAGTGATG
CACTTTTATT
'TTTAATGAAT
120 180 240 300 360 363 INFORMATION FOR SEQ ID NO:1318: SEQUENCE CHARA.CTERISTICS: LENGTH: 918 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: j) ORGANISM: Helicobacter pyloni 9 0912.2 IPEAiIJS 18DJEC 1996 93S (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1. 918 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1318
GGATTGATAA
AGCGCAGAGC
CTTI'ATGGGA
TTAGTGGCGT
GATAATAAGT
TTGAATAATG
AGGATCAATC
CAGTITTCCA
ATGGGGGATI'
CCGGTGAGT1'
GTGCGAATCG
TACGCTAGAG
TrCACGGACA
CAAGGCACGC
ATCACGCGCT
TGAAAAAGAT
CTAAGTGGTA
GTGGT1'CAGC
CTATI'AGCGT
TAA.AATCCAG
TAGAAAMTGT
AAAACTTGTT
CCTTAATGCC
TATTGGCTAA
CGTTAGAAAA
CTTrwTGATGA
TGCTAACCCC
GTGCTAATGG
CTGTATTGAA
TGCAATCTTI'
TATI'CTTGCA
TAGCAAGGCC
CACTI'CTAAA
GGTGGTCAAT
CGATTCACAA
CAATCAAGAA
TTGCAGGGT
TAAGGTTTGC
AGCGGCGCCT
TTATGAAAAA
TAACAGCGAC
TAGCGATGAA
CATCACACGC
TAGGAGTCTI'
ACITTTATAAA
TGCC'rTGTGG
TATAACAAAA
GAGGCTI'CTA
TCACAAATCC
ACCATCAACT
GCGCAAAAAG
rITAAGGGATA AAAGGGGTrr
ATGGAAAGGA
ATCTATTACC
ACAGAGATTA
GAAAAACTTT
ATrAGAGTGA
GAAGTGGATG
GAATI'GAAAG
CTI'TTGTGGG
CAAACGCCCA
AACAAAAAGC
ACATTCAAAA
TAAAAACCGA
GGATCTACTA
AGTATAACGC
'TTACAAACA
TTITAAAAGC
AAAACGCTT
AAAACGCTCT
ATCAAATCAA
TTATTAGCGC
AAAAGAATAA
GTTATGCCAA
TGCCAATITA
AAAAGGCTAT
GTTAGCGGAT
AAGTCGTGTG
TGAC'ITGGAA
CACCAGAGTG
TCTTTATGGG
ATCCAAGAGC
GTATTCTGTC
CAAACCTAAA
CATGAGTGCT
AAATGAAGTT
GAGCGATGT
GAATITTGCT
TAAAGAAGGA
120 180 240 300 360 420 480 540 600 660 720 780 840 900 918 CAAGGCAATA CAGGGCTA INFORMATION FOR SEQ ID NO:1319: SEQUENCE CHARACTERISTICS: LENGTH: 1017 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .1017 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1319
CCCCAAAGAG
TTAAGGATTG
GGGGGTrrGG
GCGGGCAGCT
CAGCATGAAA
AGAGTT1TAT3
ATTCCTAGAA
CAGTATATT
CGAGCG'ITTG
'TrTGATGT
ACTCAAAAAG
TGGGTGGGAC
CAAAAATACG
GGAGCGGAGT
CGCTTTCATT
TCCCATAAGA
TTAAAGGTGC
TGTTTTTAG
CGGTGGTGAT
GGCAGGCGAT
TTATTATTGC
ACGCCTTGCA
TTAATTTAGC
GTGCCATAGA
TGGGCGAAAT
GCATTGGTGG
ATGTGGAATA
TGGATTTGA
T TI'GGGCTT
CAATTGAAAC
TTGAT T TrAGAAG Tr
TCAACGCT'I
TGAAGGACGA
GGTGCGATTC
GCTAGTAGCG
TTTTAGAGGG
TCTT1'TAGC
ACGCCTATTT
GGTGTTTCTrr
AGAAAAGCCC
TTTAAGCCTT
GGGGACGATG
TACCGGCACC
AACGATTAAA
TAATAACACC
TT'rCAGCGAT
TGAAAGAGAG
GCATGAAATG
AGACGTCTTC
TAAAGGGTTT
TTGCTCGCTA TCCCCCAAAT
ATGGCTGGAA
CTAAACACGC
GTTTTAGCGG
TCTCAAAACG
TTITrTATTGC
TTAGTCGTGG
TTG [TAGAAA
AATATCCATC
GCTTGGGTGA
AAGCGTTATG
TArI'CTTAG
TTAGCCTC
GACGC'TITTA
GATATTAATT
ACTACAGACO
IT TCTAAT
TCGGGGCACT
AAAATACCAC
ATCAATTTGT
CCACCCAAAA
TAGCGAGCGC
CGACAAAACC
AACACCATAT
CGGCATTGAT
ACACGCTCAA
AGAAGGAATT
CGATTTCTAA
ATAGCCCGAA
AGGGCTTAAT
TGCGTTATAA
CTCAAATCAA
ATCAGGCCGG
rTTAGTGGGC
CATTGGGGCT
GAGCGTGITr
ACAAAAAAGA
TTTATGGCTC
TAGCAGCGAG
CCCTATCAAG
TAGGGGCGAT
AAACCCTTTG
TAATCTTTG
AGAAGACGCT
TTrTGATT
CAAAGCTTAT
AAGTTTrGAA
AGAGCTGGAT
TATI'GTT
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1017 WEANS 18DEC 1996 936 INFORMATION FOR SEQ ID NO:1320: SEQUENCE
CHARACTERISTICS:
LENGTH: 432 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc~feature LOCATION 1 .432 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1320 GGAGCAAAAA TGAAAAAAAT AAAGCCCATG
AAGTGAGCGC
GAGCCTAAAA
TGAAAATCAA
AACCCGCAAG
CAAGAGAGGA,
TCTGTAAGGT
ATI'CTTAGG
GCGTTAAAAC
TAGAAAATCA
AA'TI'TGCCA
AAAACCCTGA
GGCCAAGGTA
GA
TGGITTTGAGC
TGAAGAGATT
CCACACGAAG
TTITAGAGGTG
GGGCGTGGCG
AAACGCTAGT
AGAATTCGCC
TTGTGTTTGG
GCGGATATT
GGGTrTTGCG
CCACTACTCA
ATGGACGATA
TGGACAATGG
CAAITTTTIG
'rrTTGAGTTT GGGTTTTTITA TCTACAAACT
CAACGCCAAA
CTAAGCGT GTrCCTCCCT ATGAAAAAGA
AATCCCTGCG
AAAGCAAGGT
TAGGGGAATG
TGATGCTCAA
TACAGAAATC
AAATGAGACT
TCCTAAAAAT
120 180 240 300 360 420 432 INFORMATION FOR SEQ ID NO:1321: SEQUENCE CHARACTERISTICS: LENGTH: 1584 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc...feature LOCATION I1.. .1584 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1321
CATGAGTTI'
CAAAXAGAGC
GAAACGCTTT
GTGGTGGGCT
CAAGGCATTT
CATGTTrAG
NCAATACAGCC
TAGCTATTAA
TTTTAGAAAA
TAAACAATTA
TCATI'CCCTA
TrGTGCGCCC
GTTATGTGGG
AGATTGTAGG
TGAAI'GATG
AATTIGAGGTG
CCAAAAAGAA
TGCCACCATG
TTTAGACAAG
GGTGGCAAGT
cAAAACCGGC
TITGACGTGT
ATCCAAAAGT
AATTCGCTCT
CAATCCCTT1'
CGCTACTACC
TTACAAGATI'
ATTGAAAAAG
TTTTGCCCAG
?TTCCCTAA
ATAACCATAA
ATACCAAACT
CTAATAACGC
TAAAAGACGA
AATACAACAA
CAGATTGAAA
TTTCCCAAA
CCTCATTAAA
cATCCAAACT TrTAGCTTCG
TGAAGAGAAT
GTT'TTTACAA
120 180 240 300 360 420 P CT fi sC G 0/9 12 IPENUS 18 DEC 1996 G4GCAAGGTGG
GAGGTCGTGC
AAAGAAGCAC
AATGGCGAAT
GGGATCAGTC
CGC'rrCGCTA a r71 rAGAAA
GTGGGCAAGC
AAAGCCA~rA
GAAA.AACTCT
CCGA.ATGAAT
GACTGGCGCG
CCI'TGCAGG
rFI'GCTATcC
CTCCAAGCCT
CATTCCACAA
GAAATCGCTC
TCCCATGCGT
TTAGTAGAAC
AAACTCTATG
.GTTATAAAAT
CACCACGCTC
ACAAGCTCT
TGCTCGTTGC
AAGACAAATG
ATGCCTI'GTA
ACCI'CATAT
GCAAAF1'CAG
GGGAGTCCGT
CTAAMCCT
TTGTGGGGAT
TTGGGGACAC
TGTAGCCTA
ATAACCAACA
TGCGCGTGGG
GAGGTI'CTAA
AAAACATCGT
GGATI'ACGGC
ATGGGGAGGG
AGCTI'GGCTA
CATACATGTC
CAATAACCAC
TGTAAATAAG
AGGAAGTTAC
GCAAAAACTC
TCCGCCGGGA
CACAGAAAAC
GGACTGGAAA
GGATGTGTAT
AAGGGAAGTG
TGTGCCGGAT
GCTCAI'ACT
CACAGGACTC
ACCGCTCAAA
CATIGTATGAA
GG'ITACCTTA
CAATCGCATG
ATTCTT1GCCC
AGGGTCAAAA
TCTT
AATGCGCTCA
TCGCAATTGA
AGAGGGCCTA
CCTGAATACA
CAAGATGATA
TCTGTGGTIA
ACCACTATCC
AAAACAGGGC
TTITATAAGT
GGC'ITTGGGG
AATTTGTGGA
GCTATTGGGC
ATTGCGACAG
GACCCCCTGA
GTGTGTA.ACC
GCGTGTAAAA
AAAGAAAAGG
TATGAAAAAC
cTAGGGGGCT
ATCAAGAATT
GITTAGACAA
I'rTTAGTGAT
ATI'TGAACGA
TTTATAACCC
AAATGGGCGT
CCACACCGCC
ATGGCAAT'C
'rIGGGCTTGA
AAAAAACGGG
AGCTCAAACG
AAGGCTCTTT
GCAAACTGGC
ATAGTITrCA
ATAAAGACGG
CCGGCACCGC
ATATGGAATA
CCAAATACGC
TGTTAGTGAA
AGCCACCIA
ACGCITCCAA
GGATGCAGAA
TrTTTGTAGGC 'TrTA'rAAAC
GGGGTTAAGC
TITTAT']GAA
TAATI'GTAT
AATCTCTATA
CGTTGAITG
CrrrCAATCAA
TTTAGCCACG
AACGCCTCAT
AAAAAAGAAG
CACCGCTTAT
GCAAGTCGTA
'ITTCCATCGA
TATCACTAT'
AATGAGCAAC
480 540 600 660 720 780 840 900 960 1020 1080 1140 1200 1260 1320 1380 1440 1500 1560 1584 INFORMATION FOR SEQ ID NO:1322: SEQUENCE CHARACTERISTICS: LENGTH: 840 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc-feature LOCATION .840 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:l322 ATTAATTTTG TTAATAAAGG GGTTTTTATG
GCTATGT
GACCACAAAA
'rIGCAATCAG
ACGGATTATG
CAGCACCGCC
GCCAATATCC
CTI'AAAAAAG
ATITTTACTCC
GAGTTTGATA
TTGCCTAAGG
GCAAAACTCA
GCCTCTCGTG
AGCGAAAAGA
TAGGTTTTTT
TCACTCGTGA
TTGTGGATGA
TGTTG.CCTAA
CTTATTEGGA
ATGTGGAGCC
GCTCAGTGAT
ATAAACAAGG
'rrGTCAAAAA
ITITAGGGGA
CCGGAGCCT
AGGATAATGC
ccAGGAAATI'
TAACCTITITA
GCTAAAGTG
TTTGAAAGAG
'TTTAGCGCTC
TCGGTrAAT 'rrTAAGATTT
TGCTGTGCCA
CCTTATCGCT
TCCTI!ACAAC
TGTGGATGGG
ATTCAGAA
GCAAGATGAA
CATTTTGGAT
AACATATTCA
GACGCCAAAC
GGCGCTAACC
AAAGGGATCA
AATGACGGCT
?1TGGACAGAA
TATTCTCAAA
AATGATCCGG
CTCAAAGACC
ATCAAAATCA
GCTATCATAA
GATAAGGACT
GCGATAAAAG
ACCTATAAGG
AGCGTATTAT
ACCACAAAGA
CTGTGCCGCA
AATrAGTGAT C TTTAGACGC
AAATGCACCT
AAATCACAGA
CCAATCAAGG
CAAGCAATCT
AACCCCTAGA
CAGGGAATTA
CGCCTI!ATGC
CGTI'GATTIGA
GGGCGAI'AT
TTGCGTAACC
AAAAAAAGAA
TGCGCAAATC
CGTGTC'1I GAATTACrI'C Ta'rrGGTG CATrAAAAAC
CAGGGCGTTG
ATACGCTACG
AGCTGCGTA
TGCCTTGCAA
TAATCTTGTA
AGCCTTACAG
cccGGCTTTT 120 180 240 300 360 420 480 540 600 660 720 780 840 INFORMATION FOR SEQ ID NO:1323: SEQUENCE CHARACTERISTICS: LENGTH: 978 base pairs P fjf~ ~091~ IPENIUS 18IDEC 1996 938 TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .978 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1323
ATGATGATAA
C'TrCGGCGT
GCGAAAAGCT
GTGGTGTCTC
rTATTGCTT
AAFTTTGGG
TCCATCACGG
GGGCTGTTAG
ATTGGGCAAA
ATAATGCTGC
GCAAGTGTCC
ATGGTTAITT
AGCCAATI'
GTGGGGAGTI
GCAATGGTI'
GTGATCTT
CAAAATGAGG
CCAAACAATC
TTATTITTAA
TTGAAATGGA
TGGCTCAIT
TTCTTTTCGC
TGCTTCTCCT
CTTCTTTAGT
CG'ITAGGGAG
7?I1rGGATI'G
TTATGTGGAA
CTATATI'AAT
CTGGGCATT
CTCCTGACAT
'ITTrIGTTCGG
TAGTCATTG
TGCAGATITI'
GTATTCAC
GTATCAAAGA
CACCACCOAG
GAGCGCAACA
GCCCTTGATG
TCTTI'A'rr
TITCTCGTATG
CATTCGTGTC
TTCGTTAGCG
GCGATCCACT
ATTGCTCCCG
GAAACGCCCG
CACCACTI'AT
TACAACGCTA
CCGTTTGTAT
CCCGCAACTC
CTTGTGGGGG
TrCGCTITAA.
TTTGTCCCTG
GTGGGGCTI'A
CTGCTI'AGCG
TTCAGCCATA
GGTATCGCTT
GCGCCAAGAA
ATGATTTTAG
TI'TGGCGTGA
CATCTACCGA
CTTTITAGTGG
AGCTATATTG
ATGTTGTTTG
GCGAAAAATI
TGCTTTTTG
ATI'GGGATI'A
TGCGGGTT
TTGCACTI'CT
TGATCACTGC
CTAAAATI'GA
TCCTTTCAGC
TI'GCCCACTC
ACAAAAAACA
GGTI'GCCGCT
T"I'GGGGGCGT
GTAGAAACGC
GGATTATTTI
AGCC TI'AT
TGTTTGGGTT
CAAGAAAATI'
TGTITTAAAAA
CTTCACTCAC
TGTG TITTCG
GTCAGACATI'
TTATGCATGG
AAGGAAACGC
G TTAGCGTGG
TATITTTGG
ACAGGCC ITA
TGGGAGGATC
TGCGACTCTT
CGGCACGCTC
GCTTGTGAT6
CATTCAAATC
AGCAGACGTG
TATCGCTITT
CTTAGAGTGG
CATACGT'A
INFORMATION FOR SEQ ID NO:l324: Wi SEQUENCE CHARACTERISTICS: LENGTH: 264 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .264 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1324 AAGGGCArrrC AAAAGAAACA AAATC'FTAAA GAGGTGGCTT TAGACGCTT AGCATCAATT ACTACCATTT TAACGGCTCT CTCACCGCTC CTCCTTGCAC GCATGGTTTG TCATAGAAGA ACCTTIGGAL GTTTCTCCA AACAATTGGC .AAACGCATGA AAAAI'CGCC CAACCAACGC CCCGTCCAGC CTGACTACAA
CTTGCCTAAA
AGAGGGGGTG
TGAAATCAA
CACCGTGATC
POUS 96/0912.2 IPENLIS 180E C 1996 ATTAAAAGCT_-CGGCTGAGAC CCGC INFORMATION FOR SEQ ID NO:132S: SEQUENCE CHARACTERISTICS: LENGTH: 450 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1.._450 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1325
AGGATAATTA
GGCGCTGAAA
AAAI'GCACA
GAGCATI'ACT
CCTAAAGCGG
ATCAAI'ATA
TTTTTAATCA
GGGCGTTTGT
AAATGAAAAA
ACACCAAATG
AAGATTTTGA
ACCACACGCA
TCTTTI'CAC
GAGGCCATGA
ATAATAAAAC
TGGTGTI'AGC
AACTTrTI'TG
GGATTATAAA
AGTGTGCAAA
AGATAAAGCC
CCACCATACT
CTATGTGI'G
CAGGCCT1'TG
GATTGGGTTT
ATCGCTTTAG
AATAAAGAAA
AGCGGTAAAA
GA'TrGCAAT
TTAAAGGCT
GATAATGTGC
AGCGCGCATT
CGCI'ACGGC
AT3GCCCGCA
GCCAATCGCC
TCAAATACGC
CGTUI'GAGCC
ATTI'CCACGC
TCGTGCATAA
TTCTCTI!ATA
CCGCTG9GAC
CATCAACAT
CGC'ITCTAAA
GACTAACCAC
CCCTATGGAG
AGACGCTAAA
INFORMATION FOR SEQ ID NO:1326: Ci) SEQUENCE CHARACTERISTICS: LENGTH: 1149 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .1149 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1326 ATGCCTGT'rA
GCAAAAGAAA
GAAGCGATAA
G'ITAAGACTG
GGTGTAACAG
AAAGAAGTGG
TAAGAGTT
AGAAAGTT1T
AAGACTCGAT
CGGATGATTA
CGATAACAGC
CTCAAGCTCA
AGTAATGCTT
TAAGAATGTG
AAAAAAACAA
TTTAAAAACG
CATGCTTATG
AAAGGAAGCT
GCAACAATGA
GGAATATCTA
ATAAAAAAA
CATCCTAACT
AATGTGTGTr
GAAAACGCTA
TGATGAAATT
TAATGGGGAT
GCGATTGGAT
CATGGTTTAA
TTGCTGATGA
GGGATAGAGC
AGTAAAAACG
TGCTTGG
ATGCGGGAAT
TTCAGCAATA
CCAATCCAAA
GAACAAGAGT
PCTUS 9,,/912 IPENUS 18 DEC 1996 GGGATAGAAC TGGAACAAGA
GAAAAACAAA'AGACAGAACA
CAAGAAAAAC AAAAGACAAG CAACAAAAGA CAGAACAGGA AAAGCAGAAC AAAATTGCCA AAGGCTGGCA T1'GCTATAGA AATCAAACCC CTATCCAGCC GGATCAAAAG CGCAAGAGCT TCACAAAAAG CTATCGCTAA GAACTAGATC. CTAGAGATTI' CGCTCTAAAG CTCAAGCTAA CACCTTI'CAA CCTCTCAAAG GAAATAAAAG TAGTI'GCTAA
AAAAGGCATG
AGAGCAAAAG
AGAAAAACAA
CAATATAGAG
AAAACAAAAG
AGAAAATCAT
AATAGAAGCT
AAAACACCTC
TATCGCTTAT
ACAAGTGGAT
TAACGCTACA
AATGCTTGAA
ACAGAACAAG
AAGACAGAAC
ACTAACAATC
ACAAACAATA
AATCAATTCT
GAATCCAAAA
CCAAACTCCA
TTGCAAAAAG
TTTTATAGGC
GAAGAATGGC
ATGAGGAGTT
AAAA.ACAAAA
AAGAAAAACA
AAATAAAAGT
CGCAAAAAGA
rITATAAAAA
CCCCTAAACC
AACAACCCCA
AGCTAGAATC
CAAGTTCTAT
AAAAAGAAAA
TAAAACCAGA
TATrGCTGA
AAGCGGGTTA
GACAGAACAA
AAAGACAGAA
AGAACAAGAA
TTTGGTTAAC
ATTAGGAATT
CACAAAAACC
PrCTCAAAGA
TCTGCCCTAT
CGC'TATA
TITAAAAATA
CCCACAAGCC
TGT1'AGTAAA
TGGTI'ATAGT
420 480 540 600 660 720 780 840 900 960 1020 1080 1140 1149 CCTITTGCTC GTTICAAAAAA TACCGAGAAA AAAGTAGAAA INFORMATION FOR SEQ ID NO:1327: SEQUENCE CHARACTERISTICS: LENGTH: 996 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .996 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1327 AATAAAAGGA AGAACATTAA AAAGACACGC TGACTGGGGA ATGGAATITC CTGAGCCGGT GAAAAAATGG GCGTAGCGTT ACTCAAGAAG AAACCGGTCA ATCGTGGATA GATTGAAGAG GCCTAGAG AGACTATCCG
GGTGGCCGTG
GGGTATGAAT
GTGGATAAGG
GAT'I'IAAAG
'TTAAAATCG
CTAGAGCCTA
GGCGATITAA
ATCGTGAATG
GCCACTCAAG
AATATCGCTA
GGCA.ATACGG
T7GTG;AATGA
GTATCCAAGA
TACCCTTTA
CTGGCTCTAT
TGATGAAAGT
ACAGAAGAAG
CTTTCGTGCC
GGCGTGGG.AC
AGGAAATCGT
AGAAGTITAT
CACGCITI'GC
CATTCACATC
AGGCAAGCT'
AACCCTrAT'
AGAATTTAAG
CTCAAGCGTG
GCATGTGITTT
AATI'rCTGGG
AGCGATGCAA
TGATGGGAGC
GGCGTTTAAA
GGAAGTGGAA
AGGGCAAATC
GTTAGTGGAA
TTACTCTATG
GGAAAAACC
GCGGGCGAGA
GATGAAAAGA
GCTGTGGAGC
GCTGAAGAAG
GGTGGTATGG,
GTGGAAGCTG
AGCAAAGAGC
ATCAAGCTTN
GGCGTGATCC
AATGGCGTTT
TACCATGATG
GAAGCGAGTC
GTCCCTGA.AG
AATTCTATGG
ATIGTITGGT!
GAGTTTGACC
AAAGGC
?ITGCGCGTT
ATGCGGTGGT
CTAAAACGAA
ATCCAAGCTTr
GTGAATI!GCA
AAATCGGTCA
ATAAATACGC
AGCCTAAAGA
CTAAAGAATA
TGGCAGGCTA
TGGATTCTTC
GTGCGGCTAA
AATACATGGG
ACGATAGATTI
ATTCTACGGA
ACTATGGCGA
CGTGGGCTTG
TTTAGAGAGA
AGCAGACCAG
TAGGGTGATG
CCTAGAAATC
GCCGCAAGTC
TAAGCAAAGT
GCCTGGCAGT
TATCCCTGCG
TCCGGTGGTG
AGAA.ATGGCG
CCCGG
4
TITTA
CGATGTGATT
AGGTIAAA
TTTGCGATCA
AGTGCCTAGC
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 996 INFORMATION FOR SEQ ID NO:1328: SEQUENCE CHARACTERISTICS: LENGTH: 327 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular POUS 96/0912.2 IPEA/US 18DEC 1996- 941 (ii) MOLECULE TYPE: DNA (geriomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE- NAME/KEY: misc_feature LOCATION 1 .327 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1328
TCTAAAAGGG
ACTCGTAAAA
TCTTTCAAAA
AATCCTGTAG
TCATITTITA
GTGTCTAACA
CGTI'CGCAAG
GGGGTTTAGA
AATATTGGGC
GCGTICTAAC
GGCTTAAAGC
CTCITI'AGTG
AACCGTAGGG
GTTTAAAAGA
GCCTAAAGTT
TTGCGCGATA
GGTGGTA
TCT1'CTAAGC
GGGCGGATAG
GCGGGAITGT
TCAAAAATAA
AAGTATTCTA
TGTTI'TGAG
CCCCCACTAA
TTrCAAACTC
TCTGTTGGTG
AATGGGCCAA
GGACAAAGAA
AAACCCCTT'
TAGGGTAAAA
TGCTAAGC
AGTCAAAGCG
INFORMATION FOR SEQ ID NO:l329: SEQUENCE CHARACTERISTICS: LENGTH: 1314 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .1314 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1329
ATAAGGAATG
TCTGAGATTG
TI!GCATGAGG
GCAAGCT2TAA AArTrACAAG
TCATTGGCTA
TITTGCACGA
CAAGAAACAG
TTAATAACCG
GCCACTI'CGT
TTGATTGATG
GCACGAGCGG
GCTGAAAAAA
GAAGCGAACG
GGTGATGTGG
AAATACACCA
GTGGTC ITTA
,LAGCCATAAGA
CCACCATGT
CGGAGTTAAA
GTITTTGTAGG
ACAATITAGA
GGGTITCTTA
AAAAAACAGG
GCTTAAAAGA
GCTI'GCTCTT
TTAATAAAAC
TAGCGGACTC
ATATTGCAGA
GTGAACATGG
CCCAAAAAGC
ATATTCAAAC
AAGAGCTTAA
TCTACAATAT
AAAACAATCT
GT'TGCCGTT
TGGGAATAAG
AAAAGAAGTC
TATTAAAAAC
AGAACAAAGC
TTCTTTGAAA
6GGTGTGGGG
GGOCTTAGAG
GAATGCGGCT
GGGTCAAGAC
CCTCAACCAA
GCAAACCAAT
CAGAGGGTT
CACTAAAGAA
CAACACCCAC
ATCCACCGTA
CAATAACCGG
TTATGGCATG
AGGCAAATGG
CAGTI'ACAGC
AATCTCTATC
AATAAPLGTCG
GTTCATTTTA
AGCCAAAATA
GAATACCATA
AACGCGCAAG
AAAAATGGCG
ATTGAATCGC
CGGAGCAATG
CTCTTAGCCC
GCGGTGGTGG
ATCGCTGTCG
GATATTAATT
AAAAATAACA
GTGTTI'TGCG
GTCTTTGGTC
TATTIATGAGG
TTCAAATCAG,
AAAGCCTII
TTTTAAAAG
AAGAAAACGC
TTGACGGCGT
AAAATGATTr
AAAGCATGCA
AAGAGCATTC
TTTATGAAAA
AAATCACTCA
TAAACGCCGC
CTGATGAGGT
TGGTTAAAAG
CTATTGTAGG
TGATI'GTCGC
GTCTGGCTAA
TCAA?1'CCTT
GTGCGGGTAA
TCAAAAAGAT
AAATTGTGC
CGGGAATCTT
AGAAAGCGTT
GCAGTArTT
GTTTAAGACT
GTATTrCCAT
TAATGAAGGA
GATGCAAAAC
AGTCATTTCT
TATTGAGGCC
GAGAAAGCTC
CATGCAACAA
CTCTATTAAG
GCAAGCCGCA
ACTCGATCAT
TGACATI'ACC
AGAAAAC TTT 120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 AMENED SH1EET FPCTUS 9 6I/O91?2.a ,,PEN1JS 16 D EC 1996 GCTAACACTT -CAGGCTATAG AGCTTAGAA AGCCACCATG AATGATITGG T1'AAAGCCGT TCAAGAAGAT CACGTCACCG AAAGTGCATI TAATGGAAGA TAGCCCTAAG CATGTCAAAG TATIGAAAAAC AAGATGAACT CMATAAAATC ATTGAAAAAA
CGAGCGTGCA
ATTCAAAATA
AAAATATTGA
TITCAAAAAGG
TGCTGAAGCT
CCTAGAACAT
TAAGATGTI'
CGAA
1140 1200 1260 1314 INFORMATION FOR SEQ ID NO:1330: SEQUENCE CHARACTERISTICS: LENGTH: 1032 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (geflomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .1032 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1330
GAGTGGTTAA
GGGTTGTTGG
ATTAAAGATT
GCTAATA TT TTrGrTGAAA.
TTAGACGCTG
GGTAGCACTC
ACCAGAAAAC
GAAATTTI!AG
ACCGCAAGTT
ATGT1'AGTCG
TCACTCTCTA
AACGAGCTCA
AATATCGCTC
AAAACTCAAG
GAGTCTI'rGC
TGCTAAAAAA
CCGTICTI'GT
ATCGCCCCAG
ATGATAAGGA
GCCTTCTAGC
TCATGCGCGC
TAACCCAACA
TCAAAGAAGC
AGCG'rrATTT
TAGGGTAT
CCTTACCTAG
GGGCTAATGA
AATCCGCTCT
CCTATGTCGT
GCTATACCAT
GTtTTTGGGCA
GATTITAT
CGCTCAAGTr
TGTCGCTTCA
A'FTTCGTTTT
GGTAGAAGAC
TATGATTAAA
ACTCG ITAAA
TATCATCTCC
GAACCAAACT
TAAAAAACCC
GGCTCCAAGT
TATITI!AAGG
CAATGAAGTG
GGATGAAGTG
AAAACTCACG
TCAAAAAATC
GGTTATCG
TGGGTAACTA
CAGATTTTAG
TATGCGCGTT
ACCCTCTIrTT
AACGCTAAAA
AACATGGTGC
ATACGCAT'G
ITTrTGGGC
CTI'GACAAAC
TTTTATGACC
CGGTTGTATT
CCAATCGTCT
TTGAAGCAAT
ATAGATTTGG
TTAGAAAAAA
AACTTAAACG
T TrATI1r
CGGATAAGGA
ACAGAAAAGG
TI'GAAGAAAT
TTGAGCATGG
GTGGTCGTIA
TCACACGGGA
AAAAAGTCTI'
ATGGGTATTA
TCACGCTTAA
CTACCAAAAA
CTTTAGGCTG
ATAACCAAAC
TGGATCAATT
ATTACCAACG
TCGCTAA.AGA
CCCAGCATGA
GATI'ATCGTA
TATI'GCTAAA
GCGTTTGATC
CCCCCCACGA
GGGGATCAAT
CACTGAAGGG
AAAAACCCTA
AAGCAAAGAA
TGGCGTGAAA
AGAAATCACC
'rrrAGAATTT
GATTTCTTCT
TTCCACGCA.A
AGACGGGTI!A
CI'AGCGTTG
GAAGCCAAAA
TAGTTACAGA
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1032 ACTAACGCTT CTAATGATA.A AGATGAAGAC AACGAGCACC GG INFORMATION FOR SEQ ID NO:1331: SEQUENCE CHARACTERISTICS: LENGTH: 1779 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori \X ~~AEHE S Z 0 i o EET PCIUS 9 6 /091 ?.Z IPEA/US 16 DECi99 943 (ix) FEATURE: NAME/KEY: misc-feature LOCATION .1775 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1331
ATACGAACAC
AAAAGCTCAC
CCATCTCTGA
AAGCATACC
CTGTTrAA
CAATITTTCTA
AATTTTTTTG
ATCCGCCCCC
ATCAGTCTGT
GCAACAGTGC
GATAAACTTC
cAAAAGAACA
GAAACAAAAG
ACCATATATG
TTTAITATCC
AGCTCTACCC
AATAAATACT
CAAATCAAAT
CCTAATTCAA
GCATTAGTCG
TATACCCCAA
CTAAATAGCT
TATAGCATG
AAAAGAGAAA
AACACACTAT
ATAGCTACCA
AGCGCCATCG
TCTAAGATGG
ATCGTGTTAG
CAGGGATTAT
CAATGGATAC
CAAAATGTGT
ATATTC'ITGT
AT'TrGAATA
CGCATGTGTTI
TAAATATCAT
AGAATAAAGA
TAAATI'ATGT
TrTGGGATAT'
CTTGTATI'CT
AAGACCAAAA
AGGACAACCT
AATTGTATCT
CTGATGITT
TTTCAAAATT
AACAACAACT
TTGAAAATrA
TAGAAGAAAA
AACTT-ATT
GCAAGAATGC
ATrCAGGTCA
ACCATCAACA
ATGATAATCT
TACTAAAATC
?I'GGAGCGCA
TGAGAGCCT'
ATCCCATTAT
CTTTAATITAT
ATCAAGGCAA
TTTGCGAATI'
CATAAAAAGC
TGTGTTGGCA
TATGATAAAA
CAGCI!GCTG
CTCAGGAAIT
CACTcAGCT
CCATACTATC
CAGTAATCTI'
ATTTCCAT
CATI'TCCAAC
AGAAAGCATG
ATI'AT TAAC
CAATAATT
AATCACCACT
AATTGGTGTG
ACAAGATTTA
TTTCTGTATI'
AATCCATAGC
AI'CCCATAA
TCAA'ITACAG
TGATGATA
TrACCAACTT
TI'ATCAAGCT
GCTAATAAAC
AAGCI'AACA
rriTI'CAATC
AGTATTTATC
CATATAGCAA
CAAAAI'ACT
TTCATGCTAA
GTGAAAGTAG
CTAAGTATIG
GGAGCAATTG
TCATT11TATG TrAGArI'ACA ATTACAT1'TG GAAC'rITrAT
TGCTXTGT
TTGTGTGAA
TACTACTATG
TGCAAACCAT
TCACACAAGT
CTATCCATAA
TACAACGCAT
TACCCTF1'AT
AAAAACATAG
TATACTCTOG
AT TrCACCA
CCCAAAAAAA
CACTATTr
CTGGGTATAT
GAAAGTGGT
AAATACCGAA
AAAATAITAG
TACACTCTAA
TTAATTTAT
ACCCATI'ACA
ATTTTCTCT
CTAAAGAGCA
ATTGTCTTAA
CTTTAGGTCA
TTGTTTTAGA
TrATrTrAA.
TCAAGCAAGC
TTGAAACCCT
TPI'ACTCTAT
CGGCATTCTr
TCTATTACAA
GGGAGCCT'G
TATTGCCGAA
TAAAAATCTA
cGGACTGCAC
TATAGGGCTT
AATGAT'11'TT TGC'1'1CCATA
ACTAGATAAC
TAAATTT1ATT
CTTAATATT
TCTAATGGTI'
CCAAGCATT
TTTTGCTATC
ACCAGAAACA
TTTCTCTTAT
TAAAATTTAT
A'rrAGGTTr
AGACTTGWAA
TTATGCTGQG
ATIGAAGCAA
TGATTGCAAC
AAAGCAACGC
TGAGCCAAGC
AAAATCGCAA
TAATGAAATT
TATGAAAAAA
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1140 1200 1260 132 0, 1380 1440 1500 1560 1620 1680 1740 1779 TGAAAACT1'T AATCTCTC?1' TAGCGGAAAA AGCACGCTGA
AATTATCATI'
AATGAGTGCC
'rrrTATGCAA
TTTITGATGAG
ATATAATGGG
TTTAAAACCA
GGAAAAAGAG
TACACACCGC
ACTAATAGAA
GITTI'GAAA
AATAACAAAT
ATATTTCAAG
AACAATATCA
AATTTCAAA
GTAGATIT
AGTAAT1'GCA TTrTAGATI'
ATGAATAGTG
CAGGGCAACT
CAACAATAC
INFORMATION FOR SEQ ID NO:1332: SEQUENCE CHARACTERISTICS: LENGTH: 351 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .351 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1332 ACGCCCAGCA TGATAGITAC AGAAACGAGC ACCCGTAAGA TTTTAGCCTT AGTGGGGGGG ATTGA'ITATA AAAAAAGCGC TTTCAATCGC GCCACGCAAG CCAAACGGCA GTTr GGG AGC \\GCGATCAAGC CTI'rIGTGTA TCAAATCGCT TTTGATAATG GCTATTCCAC CACTTCCAAN NFO~4WNDED Sh~lL PT L 9/091 a2 IPEAUS 18 DEC 1996 ATCCCTGATA. CCGCGCGAAA. TITI'GAAAAT GGCAATI'ATA CACGCATGGC ACCCTAGCAA TTATACTCGC AAATTTAG GCCTI'GAGCC ATTCGITAAA TCTGGCTACG AITAATTI'AG
GTAAAAACAG
GGCITGTAAC
CGATCGCTTG
CGTGCAAAAC
CTTGCAAGA.A
G
INFORMATION FOR SEQ ID No:1333: Ci) SEQUENCE CHARACTERIST-ICS: LENGTH: 444 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .444 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1333
CAAGGAGTTA
GTGCAATCCG
TTAAGGATCA
TCGCAAGCGA
CAGGTTGCGG
GCGACTCAAG
ATCGTTCG'T
AGCGTTATI'G
CAACAATGGC
CACTCACTCA
ATAAAGCGGC
GCAGTTI'GGG
ATAAGGCTAT
CGGCTCAAGA
TGAI'CAAGG
TCTGGTCAAT
Tr 'TCAGGTC
AAACGCACTT
TGATGACGCA
TCAAGCGATI'
GGATGAGCAA
TGGGCAAACT
TITGGATA.AT
TCAC
AATACAAATA TCAATGCGAT AAAACTTCAT TGGAGCGA T TCAGGCATGA CGGTGGCGGA.
CCCAACACGA ATGACGGCAT TI'AAAAATCT TAGACACCGT ACGGAATCTC GTAAAGCGAT ATCGGTAACA CAACGACTI'A
GAATGCGCAT
GAGTTCAGGT
T'TCTTIGCGT
GGGGATTATC
TAAGGTTAAA
TCAATCTGAC
TAACGGGCCA
601~ 120 180 240 300 360 420 444 INFORMATION FOR SEQ ID NO:1334: Ci) SEQUENCE CHARACTERISTICS: LENGTH: 744 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) Ciii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: CA) ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .744 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1334 TTCAAGGTTT GGATAATATC GGTAACACAA GGTCAAI'CA CTAACAAAGA ATTCCAAGTA TCTATCGGCT CTACCAC'ITC CGATAAAATC \\NTCACGGCTT CTGGGGATAT TAGCTTGACT CGACTTATAA CGGGCCAAGC GGGGCTATr CTAACCAAAG GGTCAGGTTC GTATCGCTAC TTTAAACAAG TGGATGGCGT
GTTATTGTCT
CATTAAGGCT
AGGCGCGTTA
GAATGATIGTA
AMENDED SHZT
ACTTTAGAGA
GTGATCAATA
AGCGATGTGG
GGTAATATCG
GCGGTCACT
CGCAGTATAG
GCTTTAACTA
GGAAGGTAT
CACGCTTGCT
GCGTAAAAGT TI'CTAGTTCA AAAACTCTAA CCGAACAGGG CGGTCCAGTC
AGGAAGTITG
CAGATATTAA GAAAAACGAC CAGAAACCGG TGTGGAAGCT ATG.GTCGTGG GATI'GAAATC AACGATGGTC AAAGAGCGGT CTCGGACACG CCTAGACGTA TGc~rcAGAG CTAT GcAGGCACAG
GTIAAAGCTT
AGTAATrI'AA
TCAGACGGAA
TATACGGATC
AAAATTGACA
CAAGATGAAA
AGAGCATCAA
GGATCGGCGT
ATGCGAGCGT
CCTTAAATGG
GGTTAGTCAC
AAAAAGGGCG
GCGTCAGTAA
CGAAGGGATC
TGTCGATI'CG
GTI'AGCAGAA
TATCACCACG
GATTCATTrrG
AGCGATCAAT
CTTGAATTrG
CGGGCCTAGT
TACTAACTAC
GTATTTAAAT
300 360 420 480 540 600 660 720 744 INFORMATION FOR SEQ ID NO:1335: SEQUENCE CHARACTERISTICS: LENGTH: 390 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO-
(iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .390 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1335
TCACCTCTTT
GcTATCTIGC
GGGCATTCGC
ATCGCAGGGT
ATCGCGCTCT
GTGTI'AAAAT
TTGGGCTTGT
GGTTAAAAAC ACGATTCCCA TTTGCGCGAT CGCTCATTCT CTTGGAGTAA CGCTrATGAG TTG'rITIACG ATCCAAACTC TTGTGGCTCA rTrAGGCTTT CCTA'rrGGCT CAATATCCAT GTTTTGTGCT AGGGATITrA AATAT'r GGC TCGCTAAAAT GTGGGGCTAA TCTrGCGCTG TCCATGCTCT ATATCGCATG GCGCTATCGG CTTCTAGCTr ATGGACCCTC AAATTGGCCC GTCTCTGTCA TCACCGCTAG
CCTI'TATATG
GTATGTGAGT
GGCTTCTGTT
ITrTGGCCGGT TTrAGTGCCG
TI'ATGGCTIT
120 180 240 300 360 390 INFORMATION FOR SEQ ID NO:1336: SEQUENCE CHARACTERISTICS: LENGTH: 1110 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .1110 S(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1336 ik~xnrnc w c r
AAAAGGCTTG
AGCACCTI'TA
ACCATI'GAAC
CAAATCGTAA
TGAT'AAGG
GAATGCGAAG
AACGATAAAA
GATATTGCCA
GACGCTAAAA
CCGGCGAAAA
CGTTTAT
ATTCTCAACG
GTCGCCTTGT
GAATTTGC
TTTAAGGAAr AcGATTAAAA
AAAGGCTTTA
GCCGGGGCGP
GGcGATGTGI
AAATGGGCTT
ACGCGCTCAC
CCAATAAAGC
AGCCTGAACG
GGGCGAGCAA
TGATcTTGCA
TTGACCCCCT
CTTTAGACAA
ATCTTTTAGA
CTTTccccTT
CCCATAAAAA.
AGCATGCCAA
GCGCTAAATT
AAAGTTTGGG
TAGGCTTGAT
AAGGTTCTAG
.rrAGAGcTGA
AAGAAAAGGG
TGCATITTCG
GTCTGTAGGC
CAAAACCCAA
CATTGTGAAT
AATCTTGCAT
GGGGGAGGGT
AGTGGTGCGC
AAATGATATA
AAGGATcGAT ATGCGcTTTG
AAACACGAGC
AATGATCTAT
AAAAGTTGAA
GGAAGAAGAA
CGTAGAAGAA
CAATTA'rITr
TGCGCCTGTG
AACCATCAGT
AGCGTTACGC
CTTCAATGTC
ATGTGGGT
TGCCTAATGT
AACGCCCAAA
GTGCGAATTA
GTGCCTGACA
GGCGGCTTGA
TCTGTGGTGG AATTrlGTGGA TTAGGCAATC AG TTIAGC TG TI'TGAAG
ATGACAATAT
GAAACCA E G AAXIGGAATr CGCTI'GCAAA
AAGCCCTAAA
AGTTTAAAAA CGCA TI'AGA GAGGCTTr
TGGAATTAGA
GTCGCTAATG
TGGGCGAAGA
AACCATGCGA
AAGTCCAAAA
ATGGTITCTA
TGAGTGGAGA
AGCGGGCTAG
AAAAAACCAT
ACCGCTGGAG
TCAAGGAAGT
GCTGCT1GGGG
TGATCCATAA
'TATGACGATT 'rrATCGCTTA ATI'GAAGGTA
AGGATIATAT
GGGCAAATCC
CCCTITI'TGC
TGCGTTGGCT
TATTGccGGA
CAATATCAAG
CACGCATGTG
GATTTGGCG
AAGCTCAAAA
AGAATTGAAG
CAAGGAATTG
AGATITAAAT
TAGCGAGTT'
TGAAGTCAPA
TCGTTTGAGT
GCGATCATGG
GGATrGAA
TAAGGGCGAA
CGTTCAAGAT
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1110 INFORMATION FOR SEQ ID NO:1 337 SEQUENCE
CHARACTERISTICS:
LENGTH: 423 base pairs TYPE: nucleic acid STRAN4DEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (geflomic) (iii) HYPOTHETICAL':
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylor.
(ix) FEATURE: NAME/KEY: misc_feature LOCATION .423 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:13 37 TGATI'ACAAA
ACTCCAGAAT
AGGAATAAAA
CTAGGCGGCT
AAGTTrGTGC TCTI'TcATGT
TCCATGCAAG
GAAAACCGCA
TTGGTGCTTT
GAA
CCATGCAAGC
ATTTGATGCA
CTTACGAAGC
ATAAMTTTA
A.AGAAATGCA
CTTATTTAGT
TGGGGCTTTG
GTTAAAATCA
TATAGCTAT
'rGAAGGGATC
AAAACCTGCA
AGATAACCCT
GGCTGAAGGT
GATGCC
L~TA
TTCATCATTT
TACAAACAAC
AAAATCGTTG
TTAGGGATTA
ATGGGCGTAG
TI'ATTTGGAT TGGA GGG CTT TGGCCAACTC CCCTTTCTT1' ACAAAATGTC
TGAATCCCAA
AAAACAAAGA
ATGGCATA
CGATCATGAT CCTAGGCATr TTGGGGGCTT CTrTGTCGCTG 120 180 240 300 360 420 423 INFORMATION FOR SEQ ID NO:13 38 SEQUENCE
CHARACTERISTICS:
LENGTH: 231 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) IPENUS 18 DEC 1996 947 (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION .231 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1338 CGATCACCAC CCTATTCTTT TTTATTCACA
ACGCCAGAAG
CCATGGcTT CTGGGGCTGG AAGGCTAGTG
GTTAAAGACT
TTGTI GTGG CCGGAITTGA TGCGAAACGC
TATTGGAGG
GACCGCTCAT CGGTAGGGAT TAAAACTAAA
TGCTCTAGCG
TGTFI'GTCAA.
TGGCGTTA1'
GTAAAGGGT
GGTGTTGCTC
TCAGCA!FTTC
TTCGAGGC
TI'GCTTGATG
T
120 180 231 INFORMATION FOR SEQ ID NO:1339: SEQUENCE CHARACTERISTICS: LENGTH: 819 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .819 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1339
TGGTGTITTTA
AA.AAAAGATT
GATGGGCTTG
TCAGACGGCT
TACCAACATG
ATCCGCATAG
ACCATACCCA
ccTATGTTCT
GGGTTATTAA
AATATTAACA
GGGGTTGAAG
CGCCTITI'TC
GAGCTTT1CTI
AGCGTTTTAG
CAAATATTCA GGAAATCGGG TTTCCAATTT1
AGCCCAACAG
TGGTCGTCTT
ACCGAGTAAA
CTAAAGCCGG
CATGTGTGGG
CTATACCCC TAAAGAGCAT AAGAGCCCAA
CATCGTAGAG
ATTTAAGATG
CAAAAAATT
ATCTI!ATcAA
TACAGGAGTG
ATTCTCTTAA
CACACTGGAA
TCGCT1TAT
AGAAAATAAA
ATTTCACGCT AGCTTGCGGG ATAACACCCC
TAAAAAAGCC
TAAAAAATGA TGGAAT'rrrr GCATGGGTGT TTrFTAAAAAT AATGAT~rTI'
GTGTGCCATA
GATTATGACT
AATGCGAGCC
GTTTrTTAG
AGCAATCTCG
'TTTACTAATA
CCTCATTlTAG TrAAGGGCTT
GAGACGAT
ACAGGCATGG
ACTCTCATCC
TATAAAGGAG
GGGTGT'Tr
TAATCCCTCA.
GGCATGAGGG
ACGAATGGGA
GTTGCGTGGG
CCGGAAAAAG
GTAATTATCA
ACAGCG'I TT
TGGGATTTGT
TAAGGCATGA
'TTTTACAAAC
CAGCGGT'TTT
CTAAAAGCAA
TCGCGCGTTA
AAGTTI'CAAA
TTTTGGGGCA
TITTTACAAT
GTTATTI!GCC
AGAGATTTCT
AATCCTAGAC
AGAAAATATC
GAAAAATAAA
ATVITAACGCT
TTATGAGAGA
TATCGCCGCG
CGAATTII'A
TATcGGCATG 120 180 240 300 360 420 480 540 600 660 720 780 819 INFORMATION FOR SEQ ID NO:1340: SEQUENCE CHARACTERISTICS: LENGTH: 1077 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular PCTUS 9 6 /0912Z.a IPENUJS 1.8D E C1996 (ii) MOLECULE TYPE: DNA (genomfic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .1077 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1340 TTTTrGGTTC
TTTTGATI'G
ATCGCTGGGC
TCTAATGTTA
TTGTATTTTA
TCAGCCI'AA
ATTCATGATG
TTGTTGAAAG
T1'TATCTTGG TrAGGGGTCT
ATTTTACGAA
GGGACGATGA
GCGTCTTTGG
CTFI'ATCATG
GGTGTGI'GA
TTTAAAACCA
TCTCAATTTG
AG'PTTAATGG
GTTTTTATTG
TTTTGTGTGT
TCAGTTCGT
rrTGTTTATAA
TCAAATGGCT
GGGT-rAGCAA
TGAGCAGTIA
GGTTATTGTT
TGCCTCTTGA
TCGTGC?1'T1
TAATAT(:GGT
TGCCGGCTGT
GGCATGTGAA
?I'GATAGCGT
CCCTI'AAAAT
GTTTTTGGGG
GGATAATTGC
GATGCTTI'AT
GGGGCTTTTT
TTTATGCGTT
GGGFI'CTAAT
TAAAGGGACA
GTTTTTAGAA
TATTGGGAAA
TTTTCT~rTT
AATGAATCAA
AACTTCTCTC
TGGGCATGAT
TGGGGGGGCT
TGAGGCTAT'
GATCAAGCCA
CAATGAAATA
GA LTATCGTA
TTACTTTIATT
ATGAAAGCTC
CTGTATCAAG
CAAGTGAAAG
TTGGTTTTAG,
GTCAT11 G
ATCACCGAAA
AATTTTAGCG
TACAGCTTGA
TACTATGGGG
AGTAAAAAAA
ATCACGGTTA
GGCTGGTCTT
'TGATTTGGA
TTTATCGTTT
ATTTTAATCG
'rrGATTrI'CT
GGGCCTACCA
CAAAAGGAGC
AGTATTTCTT
ATITTIAAT
TmrrTTGAA
CGAGCGTTGT
AAATCAATTT
AT?1TGTCGCA
CCGCTTCCAT
AACTCGTTAC
AGAAATTI!A
'1rr TA
TITTAGAGGG
TAGGGA'tiI r
TCCCTATAGC
TGTATI'CCAT
TrTTTATCAA TTrCTATGAT
TCACGGCGTT
AAAAAACATG
TITGGATTCTT
GGACGCACTG
TAAACGC TT
GATCGTGCCG
TGAAAAACTT
TTTTCCTGCC
CACGGGCTAT
AGACGCTTTA
TCG'ITATTr
AGTGGCTGGG
CGTGGCGTT
ATACGGCCTA
GATTTATGA(;
TTGTTAATT
AAAAAGAATC
TGCTGGGATT
T TTATCGCG,
CGAATGT
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1077 TTACTGCGAT TGTATGAAAA INFORMATION FOR SEQ ID NO:1341: SEQUENCE
CHARACTERISTICS:
LENGTH: 645 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL SOURCE: ORGANISX: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .645 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1341
C)
4/
AGGTTAAACA
TTCTTTTCTC
GAAAGTTTCT
CCTACCGAAA
'CCCAAAAGCG
GCTGTGATI'
TGAACTACAA
AAAGTGAAGC
CTAAAGTCGG
CCTTTATGAC
CTACGGCTAA
ATGATAGCAC
AGTTGCATCT
TTTTGATTTG
TTTCAATAAC
GA~TTATGGCT
CGGGCACCAT
TAAGGATTTT
GCTAGAAATA
GGTAAAATCG
AAACCTATCA
TACATGCAGG
TTAGACGGGA
ATTAACGAAG
TCGCAACGCT TCTTTTCTIA CTAAAATCAA
AGCGGGTGCT
ACACTAATAA
AGGGATTITAC
TGGATI'TAC
GGAGCTCTTG
GCCTTGGGGG
TTGGGGGGGT
TTACAGGAAA
ACCCTATGGG
120 180 240 300 360 ROJOU 96/O912.a IPENUS 0 DEC 1996 GCTATGACGT -PGAACTACGT AGTTGCGGGT TAGCCACAGG GAAATGACGC AGTI'GTCTAA GCCGATCACA CGAGAAACTA ATTlTTTGAAA
TTAGGGGCGG
GGGCTATI'GG GGCGGTCTI'G GAATTTGAcc CAAGGCCAAT TCAAGAAGCT TTAGCGGCTT TGTGAITAT AACGCTDACT AAGGTACGAA TCCCAGCGGA
TAGGGCAAAA
ACGATAAGAT
CCAcTTGCGC
TGCGCTACAA
TTrATA
ACCATGGGCT
GACTCAAGCT
AAAAACCTAT
CTACAAAGAT
420 480 540 600 645 INFORMATION FOR SEQ ID NO:1342: SEQUENCE CHARACTERISTICS: LENGTH: 795 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .795 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1342
ATII'CTATC
GCTTTAGGGC
GCGG ITTGTT
CTCTTTTA
CTCAACGCGC
TCTTTATI'GC
TTTGTGGCGA
ATCTTGCACA
CTG'rTI'TAG
AGGATCAAAA,
T1 9 GGAATrGG GGG TITTAvrr
GGGGTGGATT
CAA.ATGGGTA
AAGTAGGGAA
TTTCCTCTCA
?TTTAGGGGC
TTTTrI'CTAA
TCCCTAAAAT
GCGTGCG TrT CCGCTT'rAAA
GGCTTGTTTT
AAGCGCGTTT
CTTTCAATI'C
ATTTCTTGCA
TTTTAAAAA
4
I
TAATAATCGC
TATTGTTATA
AAGCGCTGAA
GTITITATTA
AAGAGGGGT
cTTGCTCCCC
GGGCTATITAC
AACCTTTGCG
AATGAAATT
TTTACTCGGG
GTTACTGCCC
ACAACAAGAA
ccTTTTATTG ATGGGT'T1
GGGAATTTCT
GAAACGACCA
GTCGCAATCA.
TTAAGCTTITT
ATGGTGTTTT
CTrrrI'AACG
TTAAAACCCA
TTATTTGTTI'
GGGTrrGTTGT TTAATGAG1T
TAAAAGTTTT
TAATAACGCT
TGCTCACCCT
GCGTGGGAGC
CCTTACCCAT
TTATCI'CAG
CGCAATCCAG
CTAAAACTAT
TGAGCGTTTTl
TCATTCTGGT
CTAGTTTGAG
AAAACATGAC
CACTGTTI!A
AAGCTACACG
GATCAAAAAC
TAGTTTGGAA
TrrTGTrCTGG
CGTGCTGTIT
AGGCGTTGCG
AAACGCTACT
GGGGGTTGTT
CATCAATGAG
TCTTITTATGG
GcTCACGCAT 120 180 240 300 360 420 480 540 600 660 720 780 795 TTACAAGAAA ATAAATACTA TATGGGGTGA TCCGTrACTT AAATTAGAAT TGGAT INFORMATION FOR SEQ ID NO:1343: SEQUENCE CHARACTERISTICS: LENGTH: 594 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE:
NO
(vi) ORIGINAL SOURCE: CA) ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc..feature PCTil,. 96/0912.2 1PENUS 18 DEC 1996 (B3) LOCATION .594 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1343
CACATGAAAG
GAATCTI'ATO
GAGGGCGTTT
GA2-ITrGAAA GGCTTTrAA
AAAATAGAAT
AAAATCGCTC
ATGCTCATTIA
ATCACGCAAA
TI'GTTATI'GA
GCTTATGGCT
TTTTTrAACAA
CTAAAGAGCT
AAAATCCTAT
AGCAGCTCAA
TAGTGGCTAA
CCTTACTCCC
ACGGCTATC
AIW1TAGCGC CGcTT1'TGGG
TGTAATCTCT
TCTAAGGGG
TTATCI'AAA
CGCTCTAGCG
ACCCCCTI'T
cccTAAAGAT CAcAAACGCT
GGTCGCAGTA
TCCTAAGGGA
CGCGTTTTG
TTAG ITT'ITG cGTTAACAG
ACCGGCGTGC
AATAAAAAAG
GTOGTATTCT
'rTGCTAGACA
AAAGAATACA
GATGCTTTAG
GTAACTITG
GGGcTTI'A TTGGTTrTrT
AAAAAAGCGT
GTITGCGAT
AGCGCCAAAG
TITTCTACCA
CTGATAAAAT
CGCCCCAAAG
CGGAAAAATA
TAAACSGTGGT
TrTTAAAAA
GTGGGCTAAT
TGCG 11'IATA
TGATATGACG
CTATCAAGAG
TGACGCTCAA
CTTrTTTGAA.
AATTrCAGCC
TCATGTGAAT
TAI-rrATATI'
ATCT
120 180 240 300 360 420 480 540 594 INFORMATION FOR SEQ ID NO:1344: SEQUENCE CHARACTERISTICS: LENGTH: 591 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .591 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1344
GAGGGAAAAT
TTTGGGCTTG
GATITAGTGT
ACTTATGAAA
AGCCCTAAAA
CAAGAAAACC
TTGCAACCGC
CCCAGCCAAT
CAATGAAAGA
GGATCGTGGT
ATTITCAAGGG
ACTTTAAATC
CCCCCATTT
TrTTAAACAA
TCAAACCCGC
CCCAGCCCAG
AAAAAACTTT
GTrrI'TAGTG TcATAACGAA
CAATTATCGT
GCCC rTT CGCTTTGA'rr r]TTAGATITCG ATTAT1TAGGA TGGcCTTrAG
GTGGATTTAA
TITTCAGTGG
TCTAAAGGCA
TTAGAAAAGT
CCAAATATTC
ACGCTTGAI1T
GT'GGGGCGCT
GAGCAACTGG
GAATCATGAG
TAAAAAATTC
AC TTAACGC
GTITAAAGCC
CGCATGGGGA
CCAACACGCT
AAGTGTATT
GTAAA.AACGC
ATAAGATCCT
CGTGCTrATT
GCCTAAAAAT
CATGCTrAAA
TCTTACCGAA
TAAAAAAATC
TTATGCACAA
AGCGTTCTAT
ATGCGAACCT
TTI'rAAATTT 120 180 240 300 360 420 480 540 591 TTAAAATTTG AT1'IGTTAGA GGGCGATAAA GTTTITTAAPA ATAAAGAAGA ATTGATTT1 G INFORMATION FOR SEQ ID NO:1345: SEQUENCE CHARACTERISTICS: LENGTH: 1128 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE: NO PCTUS 9 6 /0912Z2.
IPENS 18 DEC 1996 951 (vi) ORIGINAL
SOURCE:
(A).ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc..feature LOCATION .1128 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:134
GCAAATCAAT
AGGGATITTTA
TFTGACCTTI'A
CCTAAATTCA
CCAAGCCACC
ACCATTGTITG
ATCGTGTTAG
CAAAATAACG
ATAGTGTCTG
AAAAACCCCT
TI'ATCCACGA
AGCAT'ITTCA
TCTAAATACT
GCATTAGTGG
ATGGGCGATA
CATAATGAAA
ATCTI'GCAAG
CATCATCATI'
ATTI'CTATGC
TTGCGCTACA
TGCTCTATI'C
GAGCAGGGTr.
TrCTATGGGC
AGAATAAAAA
CGAGCGTGTT
TGGGCTTTAG
CCGGGATGAG
'TTATTGAG
TGTGT(AAAT
GCAATGCGGT
CCCTCTI'AAG
TGCTCTATCC
GATCGCTCTT
GCGGGAGTT
TCTTGCTCGT
TAGGGAGCTA
TIGAACAAAA
TGAGTAA 1TT ATTTCCTr'r rl'TATT)AT AGGG TTTTTC
CAAGGCTAAA
GGATACCCCT
GTGCGCGTCT
TTrTGTGGGT
TGCGAAAATG
CCTI'AAGGGG
GCCCACGATG
GAAITTAACC
CC TI'CTATC
TAAAGTCATA
TGGCTTTI'G
GGCAATAGGA
TTTAATGGGG
TAAAACCCGT
GGGTTGGGCA
AGTCGCTCT
TCTAA'ITTCA
GGCTATI'TTA
ATAGCCITIT
AAGGCTAACC
ACGATGGGGG
TTGAGCAATC
TrAGAGACG
AAATGGCA
TTGGACACTT
'rrAGCGGTTG
GACGGGI'AG
'ITTGTGTATIG
GATGTGGGGG
TGGTATAACT
GGGTTTATCG
TCTATTTT1TG
AAAAAACGCC
GAAAATAAGG
TTGAGCT1'GA
AGCATGGCGA
ATATCAATCT
TTCTCACGCT
AGCCCAITTC
GCArTrGTGTr TTTATGTGTr
ATI'ACACTAA
TGCTGTTTAT
TTTTATACGC
GTT1GGGT
ACGGATTAGC
TGGCAGGGAA
AATTGTTrGT
GCAACCCGGC
CTTATAACGC
TAATAGAAAC
TTTTrTTAAT
TGATCGTGCG
AGGTGTGT
TTTTACCACA
'rITccAGTAT TrTTTTAATG
TAGCTTCGTG
TGT1-rITGCA
GTTAGGGATA
AATCAACCAG
CCmTCGCTT
GCCGTTTG
GTTGGl'lTrr
GAGTGTGCCT
TGCGGAATT
GAITI'CGCTA
AAGCGTGTTT
TATGTTTCG
TCTGTCTGTG
GGCACCCATC
TTTTGGATC
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1128 INFORMATION FOR SEQ ID NO:1346: SEQUENCE
CHARACTERISTICS:
LENGTH: 909 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .909 (xi) SEQUENCE DESCRIPTION: SEQ ID, NO:134 6
GCAAGATTTA
ACITTGGGTA
AATGGGGGGA
ATGCTTAG
CAAATCTTAG
GGCCCTCTCA
GTAGTAAC ET
CAAAATGGCA
TGGTT1'GITI TTATTG'TrG
,",AAAGCTTI'GC
'dACGCTTTAG
TTAAAATATT
GCTCTATCGG
GCGCGTTTGT
TGGAAATGCT
ATCCTAAAAG
TTCTATC'TI'
TTGATTTGCC
GTTTGATCTG
CTAGGGGGAT
TGATITTCAT
GTTTTTTATI'
GGcAGATGTT
TGGCATGGGA
TTAGGGCAT
GCTITTTATAC
GATTGGAAAT
GAAAAAATAT
TTATGCGGTG
TAAAGA'TTA
GCCTGTTATT
TGAAGAGGGG
AGGGCTTITA
TAA'TTIGAG
TTTI'TCTTTG
AATITTCTA
ATTTGGCGCT
CTAGCACTAA
TTGGGTAAAA
TACCCTTTCA
GTGTTAGGCT
GAGCAGGCTA
GGCTTTAGCG
ATTGAAAAAT
ATCTATGCGA
ATTCAAAAGA
AGTTTAGGGG
AATTAGGCTT
rI!CCTTATAT CCTT GAGTTT AAGACG I GT CTrCTTTT
GGGTGCTTTA
AAATGCAATTI
CATGCTI'GTT
TAAATGTCGT
TGACTTTAGA
rrrcA 1TTAA
TAGGCACGAT
TATrITAGCC
GGTAGGTCAT
AGGCATT-GCT
7rCCAATTAT
TA'TTETAGGC
CTATCTTTIT
CAGCATGCT
GCCGACAATA
GCTGATGCCC
AAGCATGCCT
GGTTGTGATG
CATTACTTAT
120 180 240 300 360 420 480 540 600 660 720 PUS 9 6 /0912Z2.
IPEANS 18IDEC 1996 TCGGCTTA CGCCTAAAAA AGAAAACCTA
CTCAAAAGCT
GGTATTrAA _TTrTTTGAT TGCCGGGGTG
ATGATTITA
GCAGACGTGT CTCAAGGGCC AGGGCTGT
TTTATIITCCT
ATGGGATCA
CTCTG ITTAT CCTrTGTGTT
TACCITTTAAC
TGTTrACCG
TGAATACCAT
TTl'CGCTAAA INFORMATION FOR SEQ ID NO1:1347: SEQUENCE
CHARACTERISTICS:
LENGTH: 1278 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .1278 (xi) SEQUENCE DESCRIPTION: SEQ ID 110:1347 AGGTGTGTI'A
AAATGAAAA'I
CGTTTIWITTA
AAAAAAACCA
T LTIAAGGATA
GCGAGGGTTT
CAACTAGAAA
TCGTCAGCCC
CATTTAATGA
GCGAATACG;
ATGATAAGTA
TTAGCGGCA(
TTAGAAGATT
TI'AAGGCTG'
GAAAAACGAT
CGCCCTTGT(
AAGGCTTACC
CTTTAATCT
TGCAATT'ITG
AAAATAT'
TCGCTCGCTA
TCCTCCCTT
CAAAAAATCT TTTrGACA.
GCCCTTTI T 'TAAGGGAG CAXITTTI'AA
AAATAAAGA
CTGAACGC
T
rr TTAAAATCG TTGTGGGTAQ
ATGACAGCA
TrIrAAAAACC
AAAAAATCC
CCCCTTI'1'IG AAGAGTTI11 TCTATCATAC
AAGCCTTAC
GAAAAAGCGG
TTCAAGAAI
CCTAGCGCGG
CCAGT~
T
G
GCGTTGTTTr
TAAAAGAT
43
A
TrCTrTATrG GGGCATGGAA TAATGAAGTC
AAAT'TTITG
TCTITGCTAC
CCTAGTAAGG
TGGCATTAGT TrCACGCACC
C
'rTATATITGAT
AGTTTGTTTGI
TAACGGGAAA AccACCACGA GAGTGGGGGG
AATATCGGCA
GGTGCTAGAA
ACAAGCTCCT
CTTGCTCATC
AATGTGGAAG'
GAACGCTAAA
CTCAAGGTT
AAAATJ2CAAA
GAACACCCTA'
AAGCGAAGAG. GTT1'IAGAGT GTTTTTvIATfA
GACGCGGCT
TTTAAAATGG cAAGATTATA CTCGCATAAA
ATGGAAGAAT
AGCCACGAAT
ATI'GATGCCA
TTTGATT1TA
GGGGGCGATA
AAACTATAAA
ATAAGCCTTT
GTTAGAATT
AATGTTT
TAAAAGCGT' TrATTACAAA STCAATTrTCT
TCGTATAAAG
,TGATAAAT'
LTTTTAACCC
:TTAGTCAT
TCATClTIv cGAAATGCT
GCCCTTGAT
m 'TTTTGCA CCGATCArrrr
TA;CATTGAT
rTGTrCAAAA
GTTTAAAAAT
TAGCCCTTT
GAGAAAACGC
TrAGGGATAA
CCTTACAAGC
TrAAAGGGGTI
ATGCCATAGG
GTCAGGTTI
ATGAAGTCGC
AAAGGGGTG;
AG~CCCTAGOG
CCCTGCATTT
TAATGATTCC
GAAAGCCAAG
CACGCCTACG
CACCACACT'
TGAATTGTTr
TTACACTAAT
GAcTTGGCAT
GCCTAAAACT
CTCGCAAGCG
cCC'I-CTAAC
AGTI'TATGAG,
CTAAAAGA
ACAAGGGCGT
CCTAAA.AACC
CAAT'rrAACC ATcAAGCGCT I TTGAAGTA
TTGCTTTCA
AAAATTCAAA
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1140 1200 1260 1278 INFORMATION FOR SEQ ID N.1:1348; SEQUENCE
CHARACTERISTICS:
LENGTH: 810 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
7r PCT/3 16 60 912.
IPENUS I8DEC 1996 953 (iv) ANTI-SENSE:
NO
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NME/KEY: misc..feature LOCATION .810 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1348
GATATGGGTA
GGTTTAGGGC
GTTTATTGT
CTATTAGGAC
CCTAAAAAAC
'ITTTATGGCA
CCTAGCAGTA
CAATCCATAG
AAAGAAGGCA
GGTTTGCTT'
GATTTCAAGC
TTTTCTCTAA
CAGAATTTGC
GGCAGGGCTI'
ATCATTTC
ATATCTIGGCG
'I TTATITTTT
AAAGCACGCA
GCTGGAAATA
CTATIT1'AGG
TCCAAGAATC
GGCTTI TAG
TTGAAAAACT
'rrTATGCGAT
CAAAAGATIT
GTATCGGTTTI
TTAAAAGCAC
ATGATTCA
TAAATTAGGA
cTrCCCCTAT
ATCCTTAAGC
AAAAAATGTA
CGCAGGGATC
rrGGGTGcTrT
TGAACAAAT
CGTTTI'ATTC
CAATTTGGTT
GAGCATGGAT
GACCTCTCAA
AGGGATCAAT
GA'FTTGGGTG
TTTIG TITAG
ATGACTGGGG
GTTGGTGCGG
ACAGAAGCTT
ATGCTI'ATT
TATTATT1GG TTTAcTCAAA
ATAACCGGAT
TrAATGCCCT
TCTITTTCTA
GTGTTCACTT
ATcACTTATG GrTI'TATCAG CGGCTTTAGG GAGCGCGATA
CGATGTTTAT
TTAAAGAGCT
CTGGACc'irr
TGAGTATTAG
CT'rrGCAGTC GGAT'rGTTTC
TACTCTTTGC
AAGCTrCCA
ATTCCTTGGG,
CTGCCGTTAC
GGATTFI'AAT
CGCTGAAAG
TGACATTAAC
AATACTGACT
TTrAA'TTG TATAGGGTrA
TAGGGGGATT
CACTTTTTTTr eITTCATGTTT
GCAGGTTTTC
GGATAAAACG
TTCTCTT'GTG
120 180 240 300 360 420 480 540 600 660 720 780 810 cvrrTG1.TGTr INFORMATION FOR SEQ ID NO:134 9 SEQUENCE
CHARACTERISTICS:
LENGTH: 186 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
MO
(iv) ANTI-SENSE:
MO
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NME/KEY: misc_feature LOCATION .186 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1349 TGTCTCACAA GGCACAGGGT TAATCTTCAC TTCTTTACCG GTGGTTTTrG
GCCAAATGGG
AGCGATAGGC GTTCTTGT CAATTCTTI'T CTTGCTCGCG CTCGCTT
CTGGCATC
TTCTACGGTG GC'TrATTAG AGCCAAGCGT GATGTATCI' ACCGAAAAGT
ATCAATACTC
TCG??I'
INFORM4ATION FOR SEQ ID NO:135O: SEQUENCE
CHARACTERISTICS:
LENGTH: 561 base pairs TYPE: nucleic acid STRANDEDMESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DMA (genomic) PGT/jS 3 9 6 /O09y 954 (iii) HYPOTHETICAL: No (iv) ANTI-SENSE: NO (vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .561 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1350
TTCTCTTGT
TCACAAGGCA
ATAGGCGTTC
ACGGTGGCTT
VTrTAAGGTrA
TCGCTCCATA
TTGGATTTG
ATGGGCTGGG
AAATTGTTTG
A'ITT1GGTTGA
GGGCAGGGCT
CAGGG'IIAAT
TrGTTrCAAT
TATTAGAGCC
CTTGGGGTCT
AGGATTATAA
CATCAAGCAC
TrrI'GAAAAA cAACT1'GGTA
GCAAGATTTA
TATGATTTTC
CTIcACTTCT TCTrTTTCT'rG
AAGCGTGAI
TGTAGCGTTA
AGACTATCTC
CATTATCATG
AGAAAAATrG
TTTCTI'GCTI'
ACITTTTGTGT
TTACCGGTGG
CTCGCGCTCG
TATCTTACCG
ATCTI'GTGG
ACTTTCTTTG
CCTI'TAGGCG
CGTCTTGA
AAATACATCA
TrGAATATGG
TTGGCCA
CTTTGCTGG
AAAAGTATCA
TAGGCGTGGT
AAAAAAGTCT
GGATGGCAAC
GCGCGCACTT
CCCCTTI'AAT
GGCTAATGTC
AATGGGAGCG
CATCACTTCT
ATACTCTCGT
GTTGATl'TTC
TTTTGAI'GG
CTTTAT~i '1r 'rrTAGGCCCT TGTG'TTi7CC 120 180 240 300 3 420 480 540 561 INFORMATION FOR SEQ ID NO:1351: SEQUENCE
CHARACTERISTICS:
LENGTH: 855 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .855 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1351
GAGTC:TTTA
AAAAAACCAA
AGTTCTGAAC
CAAAACCATC
CCCTATATIG
AGAGGCTATC
AAGATTI-Wi~ AATTTrAAAAG
GTATGGTTITA
GTAGGAACTT
TT'rAATTCTT
-CACAAGATTT
MAAAAATA
TGGGGTGTTC
oGC ITAAG
ATGACGCCAA
ATGTTACGCC
ATGTrrGTAGG
ATAAG?~CA
AAGTGTTGCG
CCGTTTTGGA
ATCCCAATAG
ATTTTTATGA
TTCAGGCAAT
CAAAAAGCGT
TAAACAGAAM
TCGCCAAATA
AAAAG
GTTTATCTTT
CGTGTTGATC
AAACCAACAA
ACTAGATr
TATTTTAATG
AGACGCTII!A
TTTTCAAGAT
TTGAAAGGG
TCCCAATrI'A
ACCAGAAAGC
AACATACACA
TATCCATGAA
GTATGCGGTT
CAGAGACOCT
AAAAAAGTTA
GGTTGCGCGA
CCAGTI'CAAA
AATTACCCGG
CCACGCATTC
ATI'AATCAAA
GAAAAAGCTT
TGGGTAGGAA
GACACGCTAG
AATCGTGTCG
TACACCTCTA
AATTI'GGATA
GTCATGAAAA
ATTGATAGAA
GGGTTTATTC
TGAATCCAAG'
CTCATGAAAG
TGCATATTGT
AAGTGAGCGA
TCCAAACTAT
TGAATGTGCA
TCTTAGAAGA
TGGATCAAAG
TCCATGATT
CTAATAACGC
AGAATAGAGA
AAGCTGTAAC
TGAAAGGCTT
TAAAATGTI'O
:crTGAGACA
A.ATGACAACA
TCAAGCCCCA
TAATCTAAAA
TTTGAAAAA
AGATAAGAAA
TTGAAAATG
CTCAGGCTCT
TGCTGTAGAA
rrCAGGAGGG
AGACGCGATA
AGAACTI'ACA
TAAAAGTTCT
120 180 240 300 360 420 480 540 600 660 720 780 840 855 0r*01%. rm ourzr 04T/0 9 6 /09122.
IPENIUS 18DEC 1996 INFORMATION FOR SEQ ID NO:135 2 SEQUENCE
CHARACTERISTICS:
LENGTH: 1053 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (geflomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1 .1053 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:13S2 GAATTGGTTI' TGITTTGAAAA CCAGAAGTCA ATTrAAATI'C ATTTTAATCC
AATTIGCTCGT
AGCCTTATGC
AAGCTI'TCTT
TTAAATGAAA GCCAGTITGG GGGACGGGAA rTATTGCT CTTACCAGAT
TGATTAAGGA
TATGTGATTT
GTTACCATAA
CAAATCCCCT
TTGTGGTCGT
AAATACCCCT
ACTATATCAT
TTAAGCAGCG
CTAGGGGCGT
ATGGTGAGCG
TGCGCTTGTI
AGCGCACACA
GCGATGAAGG
TCCCCTACAA
AACTCATGGC
AATATCTI'AG
AGCGTI'ITA
GTCCCCAAAA CCAGCTGGC1 GCTAAAGCCT rTGTGArTG GGGAAACGAT TA'1'IGCAAGC
GTTGAAATT
TGAAATCTAT
GCTTTTAGGC
TCAAACGACT
GCCTATAAGT
TAGCGTGGCT
GAAAGGTATG
TGAATACACC
GGATAATGAT
AGGCGATCCG
TGTGGCGTTG
TGAJAAAGGAA
TTTAGAAAAA
GCAGAGAGTG
CAACAAAAAA
TGTGTTAAGG
TATCACTCAA
GAATCCAAGC
'TTAAAATCA
GAGCAATITA
ACTCTGGGAT
TACACCATGA
ATTTTrTAA
ATTTTAGTTA.
ATTATAAAA
ATTGAGTTGA
CCTAATI'TG
CACACCAATT
TCTAAGATT
rrrAAAACGCA
TTAAAAAAAT
AGcGCGATGG GACACGCmT
AAATTAAAAG
AAAGATGGCA
TAT
AAAAAGACGA
AGGTCTTTAG
ACTTCGCCCT
CAGCTACAGG
cTTCCATTT1'
GCGTGGTCAA
TCGCGCGCCT
GCAAGCAGT
AAGAAGAAGC
TAGCCATGCT
TACCGGTGAA
AACCTTACTA
TAGGGGCTGA
CGGTGCGTCC
TAGACTTAGA
AAGCCCATI
AATACATCCC
TGAAAATCAG
ACTCCCGCT'
AGAAAATTAT
GTTTGGCGCT
AGTTTT
TAAAGGCACG
TAAGGATCAT
TCGCTCCGCT
CATTAAGCAC
AAAAACCCAC
CGTGGCGTI'A
.cATCATTGCG
TATGGTGGI!
!GGATATIGGAA
,GGAAGTGATr
TAGAGAGATC
CATGCCTGAC
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1053 INFORMATION FOR SEQ ID NO:1353: SEQUENCE
CHARACTERISTICS:
LENGTH: 31S base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1 .315 a., POUS 96/0912.2 IPEAMIS 18DEC1996 956 (xi) SEQUENCE DESCRIPTION: SEQ ID NOz1353
ACCAAAAAGT
AAAATCAT1T
ATGCCTATT
TATAGAAGCA
GGGGGGGTTG
ATGCCACGCT
TAAACAATAC
TITGTGCGT
TGCGCAATAA
TCATTAACCG
GCGCTGTAGA
CAAT
TCTATTCAAT
TTTTrTGATA
AACCCCCAAA
CCA.AAAGCTC
AGcCA?1'AAG
AAAGGA'ITAA
GGGGGATTTG
AAAAATTACC
ACGCGTAAAA
GACTATCAAG
TrATTTTTAA
TCATTCCACC
AAGAAGCCCA
AAAGCGGGTG
GCAAGGAAAT
AATGTTTAAA.
CCTrGAAGCC
TGAAAAGCTC
GTATTITI'TA
GAAAGATI'GG
120 180 240 300 315 INFORMATION FOR SEQ ID NO:135 4 SEQUENCE
CHARACTERISTICS:
LENGTH: 261 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .261 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1354
ATCATGGCGT
ccGcG?1TAG
ACTCCAAAAT
GAAGAAAGGA
AAGGCATGCG
GTAATIG CCCTAAGATC AGAAAAACAG GCTITTTATTC AG?!A.ATAAG
CTAGGGTATG
cTrCAcGccc TCTTTCACGC
CCTATTGAAA
AAAAGCGI'T TATAGAGTITG CAAAAAGCAT AAGAGGTTTT T
ATITGGATITT
CGCCCAAATT
AGCCTAACAA
GCTTACTTCA
TA TI'AATC
CAATACCCCC
TATGACTGAA
TAAAGACAAA
INFORMATION FOR SEQ ID NO:1355: SEQUENCE
CHARACTERISTICS:
LENGTH: 519 base pairs TYPE: nucleic acid STRANDEDI4ESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc-feature LOCATION .519 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:135 \'CGAGCTATCA CAACAAATCA ATTCGTAGGA ACAAACATGT TTTTTAAAAC
TTATCAAAAA
."#iACTGGGCG CGAGCTGT1'T GGCGCTGTAT TI'AGTGGGCT GTGGGAATGG
TGGTGGCGGT
POT/US 9 6/G091 IPENIUS 18 DEC 1996
GAATCGCCGG
GATACATA
CCAGTAAGTG
GATTTTAAAG
ATAGCAAATA
AATITGGAG
CAAACCGACA
TTGAGATGAT
TGCAAATAGC
CTAT1'CAAGG
CGTGAAGCT
AGAcGTTITCA AATGGGTGT ATATGGCAAG cACTTATAAG AAATTTCTCA
A'ITAGAGCAA
AAAGITTAAA
AGGCATTTCT
AAGGCGcTI'G
GACTTTTAAC
GAGGGTACGT
AATAGAGGTA
TTAAGTCAAG
ATATI'TGATC
AAGGGTGTGA
CAAGGGTGCA
TTGATAAA
TrCAAATCGA
ATTGTGCTGT
TTACTCCAAT
AAAAGAAAGG
TGATGGAACC
ATATI'ATAGA
CTCCAAAGCA
CAATTr'rGTT
CTCTATACAG
G'ITGGCAAAC
TCAAACCCI'
GGcAGAAATA 180 240 300 360 420 480 519 INFORMATION FOR SEQ ID NO:1356: SEQUENCE
CHARACTERISTICS:
LENGTH: 432 base pairs TYPE: nucleiC acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION I .432 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:13S 6
ATATCAAACA
ATCTI'GCAAG
CTCGCTCTCG
TTATGCGTTT
CAAGAAAGGC
GAAAGGCTGT
GCCATGCG~r
GGTTTGTT
TGGAAAATAC
GCGTITATCAA
CTGTGGGTGT
TAGGGGTGTT
TGTTI'AGGGA
TTGAAGTCTT
CGTTTAGTCT
GT
CCCGAAAGAC
CAGAATGGCA
CT'rATCCCTC
GTTAGCATGT
GCAATACCAA
CCCTATTCAT
TTTCCCCTAT
AGAGCAAGAA
CAAAATTCTT
AAAATAGAGG
'TITTATCTTr TGGcTAATAA
CAAACTTGCC
TGGGCGTTAG
TCCTTATAGA
TAGAATGCAA
CAATTTCTAA
TAGACGCTTA
AAAACCGACT
AATCAACGCA
GTTTGTGTTT
AGAGCTI'AAA
AAAATGGACT
TTTTrTATGGG
TTATCTCATG
TAA.AACCGAT
AT1TCTTATCC
GGTGGGCTAT
120 180 240 300 360 420 432 INFORMATION FOR SEQ ID NO:13 5 7 SEQUENCE
CHARACTERISTICS:
LENGTH: 966 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .966 SEQUENCE DESCRIPTION: SEQ ID NO:13 57 PCTUS 96/0912.2 IPENIUS 18 DEC 1996 cccc'rrAAAT
TTGGTTAAAG
AAAAAATTCG
TATCTTAATG
CTCGCTTCGC
ITAGGCGATG
ATGGTGAGAG
AcATGCAAGA
CATCAGGGCT
TTTGAAAAAA
CAGTGTTTAA
TGCTATTCTG
AAATACAAGC
GAAGCGAGTT
GAACGCCTTG
AAAACGATI'A
CTCTCT
CAAAGGCAAG
GGGTAACTTT
CTTCAT1'AGA
AGTCTTGCTC
TCfrrCCCTAA
TTGCAAGCGC
ACACTTTI'C
ATITTAAAAT
TTAACATGGG
TCGCTI'TAGA
TCAATATGGT
ATITTTCAA
CGTGGCGT'C
TTTGGCTCGC
AAATGGCTAA
GGGATTATTTI
CAAACTTI'A
AGAGCAGCAA
GTTTATAGAC
CAAGcG 'rAT rTATTCTAAA
TAVITTGCG
CCACCTTCCT
TGATCTT1TG
CTTTGGTG
GTTTTTGAAA.
GTTTTAGAG
AGAGCACTAC
TGTCAGTTCT
CAACCTrTwrr
AGACCAACAA
TTAIITTTAGG
GGCGCTAACA
AAcAAGCTTT
ATCAATTCGC
GGcGGGCTTC
ATCATTTCCA
cTGGATAATG
TTTGAAGCCT
CGCT'ITAGCC
GCGAATTTAG
ACTAGGGGAA
CGTATTTTAG
CCTAAAAGTA
TTGAACGGGC
TGCACCCCT
ATGCAATCTTI
ATAAAAAATA
TCGTGTATAA
TAAAAACCAT
TAGAT1'ATIC TTGTrTIGTG
TAGATGTGGA
AAcccACTAA 7TrGTGATr
AAAACGAAT
ATTTATGGCG
AGGATCTIT
AAT1'GCCTAT TCATcATGCT
GTITGATTTG
TT-AAAAACGA
TTAAAACCCA
TTTTGAAAAA
AATCCA7TTG TGAGCCT1T
CATAGAAAGC
ccGGCTCTTG TACGGTG'F1T
ATT-GCTTGGC
TITGCGAACGC
AAAACGCATC
CGAAXATGGG
CTACCCTGAG
TCATI'ATAAT
CCAIWICATC
cTATGAAGCT TTmrTTAAA
CATCCGATCA
AGTTTTCGAA
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 966 INFORMATION FOR SEQ ID NO:13 58 SEQUENCE
CHARACTERISTICS:
LENGTH: 1698 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NAIAE/KF-Y: misc-feature.
LOCATION .1698 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:135 8 AAAAAGTTTT
C
GCCAGTAGCG
AACGCTTACA;
ATCGGGT1TTG TrAGAATGGC TT'rATGITTIA
TCTGAAACGA
TTGATCGCTT
ATAGCGAGCG
CTTACAAAGA.
ITII:ATTCCG
TTAAATAATC
GTCTTAGTCA
CCTAATAATC
AACCTGTTCG
AGCCTGCTCA
ATAGATATTT
GAATGGGGGA
GGAAACTATG
CAATTAAAAA
CATGCAAGCA
A ACGAC'ITTG
:GAACTCTCT
!AACTCTAGA7 UAAATAGCGA =GTGTATTA Lr.TTTATAGG kAATGCCTrrr rGGGTTTAT3 rGTrGATCGC
TTTTAGGGCT
AcGATGCGAT' cTrATI'TGAG
TTTATTTACC
TCGGCGAAAG
CCTTATGCGA
TGTTITCTGA
AITATAGCGA
TCAAGCGATC
TCACACAAAA
GTGCATACGA
GCAAGAATIT
CTAAAAGCTI'
GCGATAGAGA
TTTTGAATGG
'AAAGGACAA AAAAAAACGA 'GAAAAATrr
T
!7TTTrCT ,rGGTI'GCGCG haGCGGTAT' ?rCCAAAGGC
UAAAAGCTAT
:ATTAAAATC
LTCTATcCCTr
TTAAAAAGA
TTTGTTTGAT
AAGCGATTAT
CGCGAGCAGA
GCGAACTCGC
CACGATAAGC
TGCTGAAACG
CCATTATGAA
TCTAGTCTCT
TGAAGAGCTA
TATCGTGTI'C
TGCCAAA'rrC
CAAGCAAATC
AATTTTrAAC
TCTCTAAAG
:TAATCCCTA
kTTTTTAGCG
MTATGACA
kAAAATTATT
ACAATAGGGA
TCACTCTTTT1
CGCCAACAAG
CTTTCTAGCA
AATTTCATGC
CAAGCGAGAC
AAAGAAGCCC
ACTAAACCT9 ACTTTTTGG1
AATCGTTCTJ
GTGAAATTI
CATTTGCTT(
AA6AccAAGCI
GTCGCTGAT
CTCTrI'AAA TGAAATrT1'
TTCTTI'GCAA
AA.AAACGCTT
TGGCAGAAAT
CGCTTrTTAGC
TGCTTTACTA
GAGCGCTrGT GCG 1TCGTAA
CTCTI'TCVT
CCATAAAATrr
CGGGCGATAT
AACTCTATGG
AGAGAGAGAG
AcACCTCTGP
SGGTATCATT)
r TAGAAAAAC; k AAAACCGCTI r ATTCTAAAA2 3 GCTCTCATT( 2; ATTTGTCT1' T ATGTCAATT1 G ATAAAGACGI AAAATTCTrr
CGCTCTTCT
GAAATAT'TCA
FrrTTACGCTG
CACAAACAGC
CGCTTGATT
GCCTGGTGTG
CATTAAACAC
AGCTAGGGGG
TITATAGCTTT
rrTCAAATGTC
CTATAGCGTT
AGAGAGTAAC
TGTCTTrGAA
LCCACAACATG
AATCGTCGAT
CTATATI'TG,
k TGTCCAACCC
ETGGTATGCC
r T1'CTAATTTG GC'rrrATTAT
TATTGTGT
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1140 1200 1260 1320 1380 PCT/U3',1 96/0912.2 IPEANUS 18 D EC 1996
TATITGAGCG
TCTAAAGCGG
CACCCCGAGA
TTAATCCAI'T
AACCTTTTTA
AATTATGATA
ACCATGCGCA. AGATATTIT GAT TAGAAAT
CCCTTITATG
AAGTGAAGTT
GA'FTAAAAAC
cTCTTITTGcc T1'TGGTGGGC GCCCCCAAT
TGACGCCCAA
GGACTAAA
GAAAGCGGCC
A'ITTATGTIGA
GCTFI'AAACA
ATTCACACTA
AGAAAAAGGG
cTACT1'ATGG
GCGATAT'ITI
AACCFITCAT
AAGATGAAAT
CTGTTI'GTTA
GCATAGCTGT
TAAAGAAAAA
GAGCGATGAT
AGAGAGTAAA
TGGCAGCATG
1440 1500 1560 1620 1680 1698 INFORMATION FOR SEQ ID NO:1359: SEQUENCE
CHARACTERISTICS:
LENGTH: 222 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTrI-SENSE:
NO
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .222 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:135 9 AAATCTTTTA TGCCACCCAC ACGCCCCCAA
GCGAGTATT
CCTTTGAGCA TGCTATCTCG TTATTICGCTC
TGTCTGI'GA
ACATCAAACA GCGCACCAAL AGCATGCTI'G
ATI'GCGGGCT
TrTrATATTAA ATACCCTAAA GATTCGCAGC CTTrTAAAGC TAAGGCTAAC CCTAAAAAAC AAAAAACGCG
CTTGCAAACA
TATTGAAGAA ATCAAAGCCC
CA
120 180 222 INFORMATION FOR SEQ ID NO:1360: SEQUENCE
CHARACTERISTICS:
LENGTH: 255 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii.) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1 .255 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:136O
ACTTCCGCAT
AAAI'CCGCC
TATCAAATGG,
CAATTTTTAG
GAAGAAATCT
CAAGGGTGGC TAAAGACATC ATCAGCGAGT CTCAAAACCT
TTGCGCAAGA
GTTTGTATGC GTTATTGAAA GAAAATGAAA TGCTCATTCG
CATCGGATCT
GGAACGATAA AGAGCTTGAT GAAGCGATI'A AGAAAAAGGC
TCTAATGGAG
TGCAAGATGA AAACGCTITA CAGCCT1TG AACAAAGCTT
TCAGCAATTA
TAAGA
PC'I 9/0 9 122 IPEMJUS 18ir-C1996 960 INFORMAT ION FOR SEQ ID NO:1361: SEQUENCE
CHARACTERISTICS:
LENGTH: 279 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .279 (xi) SEQUENCE DESCRIPTION: SEQ ID, NO:1361
GATAAAAGGA
ACIT1'GATGA
ATTTTTCAAG
GCCGTGAPI'G
ACCAAAACCT
ATATcATGGA
TTCT'TACC
CGACCACCCA
GGGTGCTGAT
TAATCAAGCT
ATCACAACTC ATGAAACTCG GGTATTATTA GCGGGCTTAG AATCAATGAA
ATGACTTI'GT
TTTAACCATG
CCGTGGATGA
CATTCCTAAA
ATCATAGGC
CCATTGAAAC
TGGTGGGGCT
C~TITGTGCC
CGAACATGCT
TTATAAAATC
GTTAGTCAGT
TAAGATTITA
TTTAGATTAC
120 180 240 279 INFORMATION FOR SEQ ID NO:1362: Ci) SEQUENCE
CHARACTERISTICS:
LENGTH: 783 base pairs TYPE: nucleic acid STRANDEDNESS: double CD) TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL
SOURCE:
CA) ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature CB) LOCATION. 1 783 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1362 AAAATGCTAG AAACCACTAT TGATTI'1'CT 'FrAGCGAACA
TACGATTATA
AAAATTTTTvA
CCTGGCACTT
AATGTTTTAG
GATTATCGCA
'GGTTTAGAG
CCTAA1TTG
GCGTTTTAGA
ACCTTAAT
TITTGCGATAA
ATTATTI'TAG
TAGGGGCGT'
AAAGCGCTTG
GCAGCGGGI'
AAGGGGTTT
GGAGCTG?1'T
AAACGATAAT
CGCTCCTGAC
GGGTGAGTGG
GGCGAATGAT
AGTTAAAATG
CGTTAATGGC
TAATGGCGI'
AAAAGCGTGT
CAAAAACCCG
CGTTACAGCA
GAAATCTCTC
GTGAAAAATC
GTGGAGGTAG
TTAGAGGGTT
AATGCTGGCA
GAATGGCTAG
GTTTTGAGGG
AAAAGCATGC
CCTAACGATT
GCGTGAAAAT CGGTGCGCCT AAGAACACCA
GATCATAGGA
TCGCT1TATT
AGGAAAAAAC
GGGGAGCGGC
CAATGCGTCT
TAGAGT1TI'
AGGGCAATTIG
TGAAAGA.T
TGAAATAAAA
AAAAAGAAGC
TTTGGGGCTA
CTAGGTTTAA
AAAGACGCAT
GCAAAAGCCA CCCCAAAI
G
ATGCGGGGCA
GGCTTTTAGA
120 180 240 300 360 420 480 540 600 P07; 9 6/ 09122.
WEANUS .L6uaCIs96 GGGCGTGGGC TTIAAGGGGTT ATI'GTCTAAA AAGAGTGGGG
CTTTGCCAAA
AAI-rrI'GG TcdA A TrGGG GGGCGCAGAA T1TTIGAAGAAG
CCCTAGATCT
GCCAAAACCA GAGTGCTACA AGAATATGGC ATTCATITAG
AAGAAGAAGT
AGG
INFORMATION FOR SEQ ID NO:l363: SEQUENCE CHARACTERISTICS: LENGTH: 270 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (geflomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .270 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1363
GCAACATGCG
GATAGAACTC
GAAAAT TI'A
CTCAATAGCG
AACATGATGA
CAAGAAAAAG
GTGTCGGTA.A
AAGACAGAAG
AACATCCCTT
TGGCAGCGGC
TGGCGGCTTA
TGGCTAGTT
'rrATT1'ATGA GTTTGATTGG GCTAGCAAGC CATGWTAGGG ATTGATCI' ITTAGAGGAA
AAAGGCTATC
TGG'ITATCGT AACCAAGAGA
AGTGATTGAA
AGACTTATAT
GCCCGATTGA
TAAACACGGC
TTACCCCTAA
CCAAATGGCG
AGGGTATGAT
AGAAT 'rGGC
AACCCGCTGG
INFORMATION FOR SEQ ID NO:1364: SEQUENCE CHARACTERISTICS: LENGTH: 1131 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1 .1131 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1364
AAAGAGATAA
AACGAGAAAA
-CAAACGCAAG
CCCACAGACA
AAATTAAAAT
ACTATAGAAA
CCATGAGAAA
ACGGCTTI'
AAAAAAGACA
CGAITTTAAA
TCTCATCTT
ACFI'CTTGCC
ACTATTCATC
CATAGAAGCC
CACCACCACA
AAGAGCGGCT
ATCCCCTGTT
TI'ATAATT'rA
CCACTTAT
GGCTITGAAA
AAAAACACTT
AATTTATI'CA
AGAGTGTTGT
AATA.ATGTTA
TATTCAGCGC
CTGGGCTATT
ACGCAACTTA
CCAATOCCGA
ATATGTATAA
AGCTTAGITT
?l-rAGAAGCG
AGAAGGCACA
CAATTATTTA
AGCGATTTCA
TGGTCAATTA
TACAGACGCT
120 180 240 300 360 PCTUS 96IO912.a IPEMJS 18 DEC1996 962
CAAGGCAATG
TGCCCGGAG
ATI'GAAGCCA
AATAAGAI'A
GAAAATCATI'
AACATGATCG
GAGI 'CACTA
ACAAACGGGC
GTCAATAAAT
GTAGGGCTI'G
T1TAGGGGTAG ATCAAT TTAG
CATAACGGGA
TGATTGATCT
AGGCGTGATA
AGGCA'TTGA
CTAGCACTI'C
AGACAAA TT
GGGAAGCCT
CTGTITrAGA
ACAGCCCAAC
TTGTCAATTC
TTAAAAACAA
GGAGTGATAT
TAGCTTCTGC
AGGATT1'AAG
ATATGACCTA
TAGTCTAAAA
TATTTCTGAC
GGTCGTAAAT
TACCCCACAA
cTCCCAATCT AGA ITGCGAT
TAAAGTCGAT
AGcGGATCTIT
TACCCCTAGC
TTTAGATCCT
AACCATCTTG
TCAAAGAGTG
GAGACTATCC
ATTGACCCAT
GCTAACACGC
TATAGGAATG
ACCGCAGAAG
TGGGGCGATG
AATGATCCTT
CAAAAATATG
GATGTAATTG
AACAATGATG
AAAAAACTCT
CATGAATTCA
CCGGTAACGA
CCAAACACTC
ATAcT'ITATT
AGAGGGTGTT
AAAACAAATT
AATTCACCAA
cGATCTI'AAA
CAAAATGCGT
TGTTAAACAA
TTAAAGGA
ATGGCAAGCA
TTGGCAACGA
GCCACACTAA
AAGATGTCAA
TAAGATITGTT
TCTICCA.AAA
TGAAACGCTC
T2AAAGATCAC 'rrrAATGTTG CGCTCCTlTr
AAATCCTGGG
ACAAGACAT
T'rcAGGGGTT
TTATGGCCAG
ccTTAAGACT
AGGCTATGGG
G
420 480 540 600 660 720 780 840 900 960 1020 1080 1131.
INFORMATION FOR SEQ ID NO:13 65 SEQUENCE
CHARACTERISTICS:
LENGTH: 648 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc..feature LOCATION 1 .648 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:136S
ATAATGGGCG
GGGGCGAGa-r
GTCTATGCGC
TGCGTTGATA
GCTAAAGAAG
GTGGAAGACA
TGTGAAGTGG
AATCTTTCTr
AAGCATGCCT
CAAGTGTGTr
AATGATGAGC
TTGGAGAGAA
CTGGGATI'GG
TCTCTAGGCA
TTGATGTGAG
ATCATTGCGA
CGCCCATTGA
TGCAACTG
CCATAGCGGG
TAGAGGCT!A
TGATI'GAGCC
GGAAAGATAG
AGAAGAGAAA
GTTAGAGTGC
CGCGACTGL,
CGATTCTAAC
CGTTTTGATC
AGAGGTrAAA TTTGCCCTrA
GCGTGTGAGC
TAGCGATGCC
AGGCCCGGTG
CGTTTATGCT
AAAGAAAGCC
GTGTTAATGC
TGCGTAGCGT
GCTTTAAAGG
AATTCCGCCG
AAGCAATTTA
TTAAAAAACA
ATGCTCTTTT
TTGCGTTTAG
AAAAGCAAT
TTGGAAGTGA
AAAAGGTGGC
TGTTAAATCA
TAAACCATGC
AAGTGTrTT
GTTATGGGGT
GCGTGAATTT
AGccTI'ATTC
TAGGCCATTA
AGCTrAAGCC
GGGAAAAAAC
ATGCGGCT
GGTTATCACT
AGGCTATAAG
GTT~ATGCGAG
AAACATCAGC
GTTTGGGAGC
'ITTCGCCCTr
TAAGATTTC
CAGCGCGAGT
cTTTAACGTT
CGCTTTITGAA
120 180 240 300 360 420 480 540 600 648 INFORMATION FOR SEQ ID 140:1366: SEQUENCE CHARACTERISTICS: LENGTH: 768 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
PCT"* 0 .j912a2a IPENUS 18 DEC 1996 963 (vi) ORIGINAL
SOURCE:
(A:)'ORGANISM: Helicobacter pylori ,ix) FEATURE: NAME/KEY: miscfeature LOCATION .768 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1366 GACTcAAATA AGcATCI'GA cCTAGAATCT
GAAAAAAAGA
AACGATITAA
GATATAGAGC
GCTTCTcTT
TATGCGCTAA
ATTIGTTGGGG
ATI'GATAGAC
TCTAGAGAGC
CCTAAAGAAG
ATTIAATG
GAAGCGCTTI'
AGATAGCGTI'
TTGATGV1'GC
AAGCGTCAAA
AGCGTGATAA
GTGGTITAT
CTAAAGACAT
TAGACAATAT
ATTCTGAG
CCATGAGCGA
AAGCGTTAGA
CGTTAAAAAA
GCGCTTACCG
TATATGCCAC
AAAAGTTTA
AGACATAGAA
ACAAAGCTAT
GATAGTGGAT
CCCGCCTAA
CGTAATAACG
CCAACATAAC
CGTTCAGTCG
GcAGTTTCTC
GTGGGTGCGA
TGCGGAATI'A
cc~rcAAAAC
AATCTAGCGA
TCAGAGCGAA
CAAGAAGAGA.
AAACAAAACC
AAAAGAACGA
GATTTGITAA
ATAAAGCAAG
ACGCTTGATG
C'I'FIATGTTA
AACCATATTG
TrATCGCAAA
TCACAAATTG
GATCTTAAGA
TGGTTGAT
AAAAAAATCG
GGGAAGTCAT
TrCAAATCA.A TTrTTAAGCGT
AACAATTAGA
TAGAAAAATI
ACACGCTTGA
CCWTAATCT
GGAAAMTGGG
cTAAACTGAT AAGAAATATr
AAGGGCGA
GATITI'CACA
TTATGG1TII'
TGAATGGCGA
TAAAATCGCT
GATAGACGCT
AAAAATTAGC
AGAGCTITAAC
TrrACC'Tr
TGTGATTGAT
GAGTTI'GAA
CATIGAAACG
GACCGGCTGT
120 180 240 300 360 420 480 540 600 660 720 768 INFORM4ATION FOR SEQ ID NO:1367: SEQUENCE CHARACTERISTICS: LENGTH: 588 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .588 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1367 r=GCAATGCTA GGACTTGTAT TGTTATATGT
GGATTAACCA,
TCCATrrGTTrr
GAAGGTGCAG
ACTGGGTTAT
GATITGGAGAC
ATTTTIATCCC
GATI'GGTGGG
AACATCTTGA
T'AACCGCTT
AAGTCGATCC
GTA.ATGTGGT
AAGATATGT
TGTI'rGGTTT
CCTATTCTI'G
ACTATAGCGA
CAATCATATG
AA.ATCCC1TTT
GGATCCCTGC
TAAAAGCACC
GGTCATCACT
TCAAGTATCG
TACCTACTTG
GTATAGCTTA
TATGCTITGAT
GTrGGCTTGG AGGGAAATrC
TTGGTTACTC
TGGGAT1TGTC
GCGGTGATGA
TACTCCGCGC
CACCATTTGA
TATGCCGCTA
TI'CGTAGCGA
GACCACAAAG
GGTGTTTTGT
ACTCCATGGC
TI'TATCCAAC
TTAATCAGCA
ACTTTIGT
TCCACCCTAC
CCAGTTTCTA
TCAACCACAC
TCAACACTGT
TGTTAGGCAT
GGCTTACCGC
TTGCTATCAT
ACTGGGTG
ATGGGATTGC
GGwcGGAcTr
AGCCCCTGTA
TGGGCCAGCG
TTTTGGTTG
TCCTGCTGCG
CACTGAAGGC
TTrCATIGAA
TGAGGGTATT
120 180 240 300 360 420 480 540 588 INFORMATION FOR SEQ ID NO:1368: SEQUENCE CHARACTERISTICS: LENGTH: 1920 base pairs TYPE: nucleic acid STRANDEDNESS: double .4 t- I I P CT/L 9 09 12a2.
1PENUS 18 DEC 1996 964 TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori.
(ix) FEATURE: NAME/KEY: misc_feature LOCATION .1920 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1368 AGCATTTGCC ATGAATATIT AAAGGTI'AAT TTTGTGCATI' ATAATGAAAA CGCCAAAGAC GGGGTGGATG CTITGAGTAA AGACGCGCT TCTAAAAATG GGGTTI'A CTTrGTCAAT GAAGATTTGA AACGCTATGC GGAGTTTT TACCTTAATG TAGAAATCAT CAGCGATCAA GCTGATAAAA 'rrAAAGCGTA TTACAAGCAA TI'ACAAAGAG ACAAAGAATT TrGGACTAAA GGGTGGGATA TTAACCATAA GGAAGTGTGT CTCATTTGCG ACCACAGCGG GAGTGGGAAA CTAGCT 'TCT ACTACGATCC CGATGAAGTC GTGGAA'LTTA ACGCGTATGT AGCAGATCCC GCGAGTTCAA TCTCTTATGG CATCACTTI'C AGAGCCGATC GGTTCAAGCA GTTTAATGTG AAAATGCCCA GACTGATCGT GGTGATTGAT TCCACTAAAG CGGTGGAGGG GCATITAAAC GTGCA~fl'GG TTTGGCCAC TCAAACCATG GCTCAAATCG CCAACCGCAT
CGCTI'IGCCT
GGCGATGATG CGGCTTGTGA GATTCAAAAC AATAGAAAAT ACCACACCAA GATGAGTGTC CTCACAAAAA TACACGCTGA ATTI!AACCAA TATAATGGCG AGACACCTTT AAAAATGCCC CATCTGGGCA AAAAAGTGGA TITATGAGCAA GAATCGCATI' TGTTGGTGGT GATCCAAGAT 'ITATrrCCAAA ACGTTAAGAG CGCGAACAAA TrGATAAGGT CTTTTGATGC ACAAAAAGAA AGCGTTTTIAG, ACACCGCTAT GAATCCTAAC GCGAAAGAAT TGCACGACAA AGTAGGGGCG ATAGACAACG AGCAGTATrG CGTCATI"IV TACCATTI'G ACAAGTIAAA AGAATTGTFA AGGTGCAATQ GGGAAAACTT GAACGCTATC AACGTGCTAT TGATAGAGCT TITCCAAAGAC 'I GCAAGAAA
TCCTTIGCCTI'
TATTATCTAG
TI'GGAGAGCG
AAAGACAGGA
GGTATTAAAT
AAAAAGAAG
AGCTCTCAGC
TTrAAAATCG TCCAA I'ICT
CAACTCTI
GCTTTAGAGC
TTGAAATGGC
AAAGATTTAA
GAATCAGG
ACCCTGCTTA
CGCGGCACTG
ATGGATGCAG
CCAGAAGGCA
CCTAAAGCCC
AGAAATCTCG
GACACCCTTA
AAGGACCTGA
TTAAACGCTC
GAATTGGT1T
TACGGCATCA
AGCGCGCTTG
GAAAAGTTAA
GCGCATGACT
AACAACCACFI
AAAAGCGATI
AGCGI'ACTG
AATTAGCCGG
TAAAAGCGCT
AAAAGATCAT
AAAAAAACAA
cAAGTTTIGA
CCCAACACAT
TTAAAAGGGA
ATGAAGTAAG
GTAACGAACA
TGCATGTGTT
TGTrTAGACTA
ATGCGAGGT
TTTGTGATGA
GCGATTACCG
TGCTTTTTAG
AAAAGGGCCG
ACATI'AATCC
AAGACAGCAG
TTTTCAACAA
CTGATGATr
CACCCATAGA
AGGCTAATGA
TAGTGGAGTT
GCATCGCTTT
TTGCAATAA
CGCCTGTAGA
TGATAGACAA
AATCGrTTr
TTAGGCAAAT
TCAAGCAATG
TGCCTCCACC
AATI'CAGGCC
r'ITrAGAGAT
TTTTTTAAGC
GCGTTFI'GGC
rCAATCCGCA
~GGGTTAAAA
GCAAGACTTC
GTI'GAAGGAC
CGTGCCGGTG
WAACACACG
GA
T
ITCAAAAT
TAAAGAGGGG
GGTGAGCGTG
AATGCAAAAA
CAAACATGAA
CGATAATAAA
TAGCTATGGG
AAGCTTTAAG
TAGTGmI'TG
CAACGGAGGG
CAAATC'TT
TCGTAAAATC
AATGCGTI'TG
T1GAAAGTAAC
AATGAAACTC
AGAAAAACGC
AAATATTTTA
TCTCAACGAA
AGAAAAAGCC
TAAAACTAAT
CCTAGCCTTT
AAGCAAACT1' TrI'CAGCTTA 120 180 240 300 360 420 480 540 600 660 720 780' 840 900 960 1020 1080 1140 1200 1260 1320 1380 1440 1500 1560 1620 1680 1740 1800 1860 1920 INFORMATION FOR SEQ ID NO:1369: SEQUENCE CHARACTERISTICS: LENGTH: 264 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
1(iv) ANTI-SENSE:
NO
AMC-Ivi iTD P7TIV "1 O912.2 fEAN1180JEC 1996 965 (vi) ORIGINAL SOURCE: .ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .264 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:l369
AGGCCCAATC
GAAAGCACCC
TCCACAAGCC
ACCTTACAAG
AcccAAAGAT
TCTCTAGCCA
TCCAACAGGA
ccATGGAAT
CCATGAACGA
CCCACCCATG
GTTCCTTTAC ACGGAAATGC TI'rAAAAAAA ATCTTAGGGA ACGATI'GGCC AATCAAAAGC ATITAGACATG GGTGCAITIWII
CCAC
TGAGCTTAAA ACTAACCTAT GAAGAAGT CATAATGCTA TAGGCAATCG TrTCAI!AAA TTAACGCT'A CGCTCAAACA INFORMATION FOR SEQ ID NO:1370: SEQUENCE CHARACTERISTICS: LENGTH: 669 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc-feature LOCATION .669 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1370
GAAAAATCAA
ATCGCCACTC
AAGCTAAGAG
TTGCAAAAAC
CTCAAGCCGA
CAATTCACAG
GGTrATTGC
TATCCTTTCC
GAAATGCTCA
GATGCGTTGA
GACTTTATTr
CATTTGCCA
CGAGCAACT'
ACAAAGCGAG
GCGCTATGGT
TAGACGATGC
TCATTTCACC
ACGCGCCGAA
AAGTTAGGGG
CCCCTAAAAG
TGCGCTTACT
GCTTGGGGGG
ACCAGCAAAG
GAAGAAGCCA
ATCGATAGGC
GAATATCTITA
CT1TAGATAAA
AATAGAGGAC
GTTCAATGAA
CAAAAATGGT
CTTGTATATA
CTCCAGCGCG
CATTIVAAT
GATTTTGACC
AGCGTTTOGA
TTATGCGTGA
AGGATAAAAA
GTTGTI!GCTA
TACCAAAAGA
GAGGGTGCTr
GCTAACATGG
GAGCATGAAA
CCTFI'AGTGC
CTGGCCAGAA
GAAAGCAAGG
GAAGCAAGTT
AGCCAAAGAG
TGATTGAAAT
AAAAAGAGCC
GTGTCAGGCA
ACCCTCAATT
AAT1WITrATT
AAGACGGGCA
AATTGGAAGT
GGCTTTTAGA
AAATAGAAGA
GATATGCAAG
CATGAAAGAG
AAGCGAATG
AGAGAGTTTT
AATTCAAGCG
TTTAAGCTGT
GCCTAA.AGTT
GTITI!GAGA
GATCTAAT'
TAAAAACAAT
AGCCCTAAAG
120 180 240 300 360 420 480 540 600 660 669 INFORMATION FOR SEQ ID NO:1371: SEQUENCE CHARACTERISTICS: LENGTH: 339 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO %in 0 PCT/U /0 9 12z2a JPENJS 18DEC 1996 966 (iv) ANTI-SENSE: NO (vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .339 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1371
ACATGGGTGC
AGcTATGGCG
CTI'TATGCGC
AACGACGGGC
ACCCTAGAAC
ATGCAGCATG
ATTTTTTAAC
rTTTGCGGC
AAACTTCTAA
AAAAAATCTT
TAGACGAAAG
AdAG TTTATA
GCTTACGCTC
GAGTI'TGAAT
CATGGTGATC
ATTGAGCTTG
CCACTTGTGC
cTCGCGCCTT AAACAACCCA AAGATCCCAC ATGGAATTGA
AAAAGGCTTT
AACTGCGTTA
AAAGCGTCCC
CAAAGCCCTT TTAACCAGCT GCAGCAAGCG TT'CAAAACGA
TATATGTCT
CCATGCCACT
AAGcATTAT
CTTATCCCAA
CATAGAAAAA
CATT AAGGCG INFORMATION FOR SEQ ID NO:1372: SEQUENCE CHARACTERISTICS: LENGTH: 468 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii-) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .468 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1372
CGAGCTI'CAA
TTAATCGCTC
AGCTTGAATG
TCTTTTACA
TYv GAAATGA
AATCAAGGCT
GGCATCATCA
ACCAATGGCT
TGA.AAAACTT
TGAGTCTGCC
GCACGGCTIT
ACCCGGCTAA
CCACCACCGT
TATATTCGGT
ACACTATAGG
TATCACAAGG
TrCCCCACTC TATTGTCTrA CTTGCTI'TCT TATGCGAATG AGGCTCGGCG TATGTCGCTG CATGGGCTI'1
ACTAACGATT
GATCAATATC
CCGGCCTTTA
AACAAGT1'TA
GAAATTGATA
GTTAGGCAAT
ATCCTTAAAG
TATCAATCGT G'rTCAAGGGG AAAAGCTCAA AAAACGCCAT GC'rI'TMAAT
CCAAGAGCAA
GGGCTAGGGG TGCTGACGCT GGGGCGAAAA CAGAAGCGAA GCTTTAAAGT CCCTACGACC AAAGCCAACA AAATATTA CGCTTGGCAA
TACGGCCGCT
TTATGAAC
120 180 240 300 360 420 468 INFORMATION FOR SEQ ID NO:1373: SEQUENCE CHARACTERISTICS: LENGTH: 651 b ase pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (gerlomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
AMF~!r PUP_' 931,/0912.2 IPEAIJS 18 DEC 1996 967 (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .651 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1373
GCGGATCGAG
ACCCCTAAGA
TIGAATGCCT
GAT1'ACGGCA
AGCCAAAAAG
TCGGCCAAAT
GATGATATG
GAATATGTGA
GGCCTGAT
CCTTCTTTGC
AGGATAAACT
TCATGACGCT
CTAAGGAGCG
TGCCAATr
CGATCAAAAC
TGGGCGATAT
GGATI'GCTGC
T-TrTAGGGAG
TCCAAAGGTI'
CTTTCCAAAA.
AAGATT1TAGA
CTCTCACTCT
TTTrTrTGTT
GATCCGACAA
CAGACTCATT
CGATAAAGAC
TTACATGACT
AAGGGATTIG
GGATAT1TT TcAAAAAAGC
CTTGACTCAA
ATAATCATGC
TC'ITGCTCTA
GAAGAAGCCA
TACATTAACA
CACAATACTG
AAACGGAGCA
TTTGGCAAGG
AAAGGTTTAG
GGGGAAATTA
AAAATTGCTA
GGTAT'TI'AG AAGCGCTTTT AGCACCCITI'
TTCTAAGCAA,
ATAAAAAAAG AGAAGAGACT CGCCGGTI'F1
AAGTAACCCT
TTGTTTTAG
TGAGCTATGG
GGAAACGCCA.
TCCTTTATGA
TrAGGATTGA GCGAGCTrrCA TrATAAGCTC
CCAAAAATGT
GGATTTGTI1T
CCTAACCCCT
AAGAAAAAAT
ACCCTATGAG
A
120 180 240 300 360 420 480 540 600 651 AGACAATGAA AACGCTGATA INFORMATION FOR SEQ ID NO:1374: SEQUENCE CHARACTERISTICS: LENGTH: 708 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .708 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1374 GAAATCGCTG AGATCGTGAG GAAAAAAATA GGGTITI'AAA AAAGCGCTcA. AAGCGATCGC AACAAGCCCA TAGGGAGTTT GCTAAAGCI T TGGCGCAATr! AGCGAATACA TGGAAAAGCA GGCTATGAAG AAGGCGGGCA TTATI'AGATG AAGTGGAAAA GATGAGGGGC
ATTTAACCGA
ATTI'AACCA GCAATGTGGC AAACAAAAAG
CGATCAAAGA
TI'AGATGAAA TCATCTCCI'
CCAATGGACG
CATTGAAAGC
TAAAGCGATI'
CCTCT'TITA
CI'GTTTGAT
CGCTATCAGC
ATTGACCGAA
AGCCCATCCG
TAGTAAGGGC
TAGCGGCGCG
GAGCCTGAGA
TAPLCGCCCTA
CACATCCCGT
GAATTGCAAA
AAAAGGAATA.
GGGCCAACAG
AGCGATAAAA
CGTCTTAT1'G
GCGGTGCGCA
GATGTGTII'A
GTGAGGGTGG
CTITTAGAAG
cAATTCTTCA
GATAGTCATG
TCCAAAAAAT
AAAGGGTGGT
AGGCTGGGCT
GCGTGGGTAA
ATCTTATACG
GGGCCGCTCC
GAAAACCTTA
ACTrCTTGTTT
AITTCAAAAA
AGGATTTGAG
AGCCGGAATT
CTATCATC
GI'CCAAAGC
GGGGCAAGAA
TAGCGATAGC
AACCGAGAGC
AATTGACATG
TGGGTATGTG
TAGCGTAGTG
ACAGGTTTTT
CACGAT1'TG
TGAAGCCGAT
TTTAAACCGC
120 180 240 300 360 420 480 540 600 660 708 INFORMATION FOR SEQ ID NO:137S: SEQUENCE CHARACTERISTICS: LENGTH: 777 base pairs TYPE: nucleic acid U S 45* A~ PCTUS 9 6/ 0912a.2 I PEAAJS 18 0E.C 199 6 968 C-C) STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION I1.. .777 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:13 7
GTGAGGTT
ATG TI'GATA
GCTGGGAT~
T
TATATTI'CGC
TTITTAAAAT
TCTATGGCCA
ATTGTGATCC
ACCCAAAGCG
TTGGGCATGA
GTGATCATGA
GGCTTGGCGA
AAATCCTTAA
ATGGGAATAT
GTTATI'CTAA
AAAATATAAA
ACACGCT1'AT
TAACTTIT
AAATTrCT'rr CCT1'GATGTT
AGCTTATCCA
TTTTTGGrTr
CTGGTTTAGC
GTTTCGC'i-ir
GTGCGAGTAA
TCCCTI'GT
GAA.AATACAA
TGATCATGAC
CAATI'TATT
AAGCCCTTGC
AGAGGATATI'
TGTGGTGGGG
TAGCTTTTCG
GCATTI'TTA
GAGCAAATCT
GGGTTGGACG
GGACGCTTAT
ATTGGTGGCT
CCGCGCGATI'
AAATTCTTTA
AAAACGATTA
GAGACAGCGC
GTGTI'GCCTT
AAAGATGGTA
~TTTTCGCTCG
TTTCCT1GG
GGCGTGTTTC
AACAGCATGC
CCATGCATCG
GGCI'AATGC
TTAATGCTAG
GAAATTGT'IT
GAAAGCCTAA
TmATAAAAA cTCT t
TI'AAC
TGATCCCGGC
AGGCTAAAAG
TGTTTTGGG
TGAATTATAT
GTTTTGCGCT
AGCGcTTI'A GGccGATATI'
TTATGGTGGT
AAAGAGCGCT
CAGGGTTGGT
CTAACTr71I:
GGATTGGATG
TrCGCTTITA
GTATATGTCT
GGTTTCGGTT
CGTGGGCATG
CGCTGGGGG
TTTGTATAAA
CCCCTTCTr
CACTTCTATA
GTTTGTAATG
TTTGTTITA
GCTTATI'TA
ACAAAAT
120 180 240 300 360 420 480 540 600 660 720 777 INFORMATION FOR SEQ ID No:1376: SEQUENCE
CHARACTERISTICS:
LENGTH: 594 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY; misc-feature LOCATION .594 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1376
ATAGGAGGTG
GTGTTTGTT
AACCTCCCCA
GTTFTTAT
TTTGACAAAT
AAATTTAAAA
GCTGATTTAA
CACAATATAG
GAGCATGCTI'
CGCATGCGTT T'ITATATTAT ATAGTATTGA
TCCGCAAGCT
rI'GCCGTATG
GCTTATGGGC
TCAACACAA
TCTCAGCCAT
TGCTCAAACA
AATCCTATCC
GCGATCTCGC
TAAAAACCTC
ACACGCCAAA
TAGCGGGTGC
AAAATAACAC
CCTTGAGCCT
ATI'TICTAA ACGCTTGAAG cTTAcATI'1T TACGC ITTCA
GTTTTGGGCA
AAAATCCGCT
CAAGACACCC
TCTCAAATCT
GAAAAAGTGG
AAAGATCACG
GCTTTCATTC
TGTTTATTGT
ATTTAGGGAG
TGTTCGCTTI'
TATACCATGA
AAAAGACTTT
TAGCCCGCTA
ATAACCI'I'
CTAAACATTC
ATAACGATTT
GGGTTTTGGC
CTATAGCTT
'TTrCATGG
AAA.AAAGGAT
T'rrAAAAACA
TGATTTAAAA
TAAACATTAC
CCTAGCTTAT
GAAAAACGCC
120 180 240 300 360 420 480 540 -1~ IPENLS 18 DEC1996 'TrTGAAGTT TAACAAACGC GCAAATCCCT TTGGAATI'AC GCCGCTACGC CTTA INFORMATION FOR SEQ ID NO:1377: SEQUENCE CHARACTERISTICS: LENGTH: 1374 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (geflomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .1374 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1377 cAAGATAAGG
AACATTI'AA
ATGGACTTTA
CTCAATCAAA
ATGGAGACTA
GAAATCTI'AG
TTrAGAAATA
TTGACAAAAC
TTAGAGCTTA
TCTCAACTCA
ATTTCTGGGG
AGCGTGATCC
CAT1'CTGG
GAATTCACTI'
AATTCC'rrGC AATGGGAATr
GTGGGCTL'GA
GCTrACCAAC ATGGGGT1'AG
TTGGGTAGGG
AACACITTAT
GGCGAAATGC
TI'GCAATACC
GGTA'AT
GCCTTTCTGT
CCCCTCCCAC
TGAAGCTGT
AAGAAAACCC
GCGTAACAAA
ACGCTACCAG
TCTCTGATTT
AAAACAAGCG
GCAAACACCC
GCAATGGCAC
TTGGGGGTTA
CTAATAATGT
TGAGCGCGAA
TCTCTGTGTT
ACGGCTATGA
GCTATCATT
AATTCGTCAT
AGAGCCGTAA
ATCTI'I'GAT
TGTACCGCAA
ATTTGTGGCG
AAGATCTTAA
GAGTGTAGCA
CCTTCACAAC
CTI'ACAGGAT
TGGGGGGAAT
GCTTTTTGCG
AGATCTTCAA.
CCTTTTAGAA
TAGGOCTAGA
TTTAGCGAT
CAATAACCT
GCTI'TATGGC
TGTGGCTrAT
GGATGTGGG
TGAAACTTAT
GAACCAACGC
TTTICATGTTC
CATAGGCT'G
GCATI"CAAAC
ATATTTTGGT
CAAAGCTAAA
GGGGGAAATT
T1'TGATGTAT
TATCACTGGG
CTACCTAACT CAAACAACGC CAGATTAAAA TGtCTTATGG TACATTGTGG GCATTCAAGG AACGCTATCA AGTGGcTTTC CCGATrI'ATr TAGAAAACCA AACACCGCAA GCTTGAFI'TC ATGGCGAGT' ACACCCAACA
GAGGGAGAGT
CCTAACCCTA
TGGATITCAAG
TITGAATGTGG
GGCTATAGCG
ATGTATGCGA
GGAGGCAATG
TACAACTACA
AAACAAAAAA
AGCGGGATGA
CCTTCTAACG
AAAAATTCCT
GGCGACAATG
TTAACACTT
GTGAATGCGG
AATGTGGGCA
GTGAGGTI-tI
GGGTGGGAGG
GCTATGACCG
GITTTTAACGG
GGGCTWITr1 9
CGAGTCATAT
ACACCTGGAC
GCGTGGTGCT
AAGGTAAAAT
AATCGGTTT
ATI'ATTGT
TGGTGCGTTr 'rTGCGAGCGT
GGGTGGGGCT
T GCGAGTGGC
CTCTCAAAAC
TAATAAAGTG
ACAAAGCGCA
AACATr GATG CTCmTAhAT
TAACCCTAAT
AACCAGCCGT
AGAGCGCTTG
TGTCAAATAC
AGCGAGCTI'
ATI'GGTTAAA
GAACATCATG
GAAAAGAAAC
CAAT'rCTICT
AACGAGCGTG
AAAACCTCAA
GCAAAATCCA
AACGCTCAAC
AACGGCGAGG
TGTGGGTGAA
GATCACAGGA.
TAAAATGGGC
GTTT
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1140 1200 1260 1320 1374 INFORMATION FOR SEQ ID NO:1378: SEQUENCE CHARACTERISTICS: LENGTH: 753 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE: NO PC I i jT 960912? 11PEMJS 18DEC1996 970 (vi) ORIGINAL SOURCE: (A)y ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION .753 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1378
ACGATACTAT
ATTATTAAGA
GAAGCCCCGT
GCTGATI'ACT
GGGCCTTTCA
GA'ITATI'GGG
TCCACTCGCG
AATGAAGTGG
ATCGCCAACT
'TGGCTATCA
GCTCAAAAAA
CCCTACGAAT
GGCTTI'AAAA
GCCCAGGGGC
GCAI'GAAGC
TThGCGAA
TGGCTCAAAA
AATCTTr GccTTAAAGC CC ITAGCGTT
AGCAATTAGA
GGC77 TATT
ATCATGCCAT
TGGTCAATCC
ACGATTI'GAA
CCAATATTTG
TAAAAGCTAT
TrAGATGAC TrI'GGGCATG,
TAATAAAAAA
GTGGAATAAA
GTATITGGAT
AAGAACCGGT
AAAACTTCAT
GAACACGCAA
CAATGTI'GAT
CTTCCCGCCC
AAAGGCTAAG
TACATC'ITTA
AAGTATTGGG
TATACCATI'A
GAC'TITTTAA
GACGAGTI'GG
GATGAGAAAA
AAGGTGGTGG
GAAATCATGC
AATATCGTIGG
AAAAAGTA IT
GATTIACATCA
ACCATATGGG
GAGI'G'TGA
CTC
AAGGCATGGG
GATITCACGCT
GCATTTTGAG
CTAAAAAACC
TCATI'CTGGT
TGCGCACCAT
TCATGACCGG
TGGATAGAAG
TTAATAACCC
AGGTGATITA
GTTATAACTA
AACAAGCGGG
CATGTCTCAT
TAATGGGCCA
TAAGGAITAC
TGTTGGGACA
TAAAAACCAG,
TCATAATiT
GCATAATCTC
CCCTGGGI'G
TTGGTGCGT
TGAAGGrrr
TAATATCAAA
CTATCCTAAiC 120 180 240 300 360 420 480 540 600 660 720 753 INFORMATION FOR SEQ ID NO:1379: SEQUENCE CHARACTERISTICS: LENGTH: 2637 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .2637 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1379
ATTCATAT'A
CACATITGCCC
TTG'rrrGTTA
AACCAAATGA
ATCGCTTCAG
TTAAAAI'rCC
TACACTI'CAA
TTI'AAAACCA
ATCGCTAACG
GGGGGGGAAT
AAATACCATG
TATAATATCA
ACCACCAACA
GAGCATTCTT
ATCGGCGATA
ATTAGGCCTG
CAAGAAAGCG
ACTTCGCAAA
AACGAA'Tr
CACTCAAACC
AAAAAACCAA
ATCACTACCA
GGCTAAAAAT
AATACGAAGA
CGCTCAATAC
AACTCATCCA
ATTTAGAACG
TTATTTGG
GCAATGGCGA
GCGGGCAAGA
TTAAA'ITACT
CAI'GCCTGA
ACGATAAAAA
ATGGCTCTAG
CGACTAAAGT
ATAAAGTCGT
TTTACTrAAk ATrCATGATT
TAAGGATTTIG
AAACGCTTTA
CCGTTATGGT
AAACACCT'A
CGACAAAGCC
ATCCGCTAAC
cTI'AAAAGAG
AGGCAGTAAG
AGATTTAAAC
TrrTGTTTTTA cAATCAAAAC
AGAAGTTTTC
CCCCACCAAT
TTTTAAAGAA
GAGCGATTT1G
GGATGTGAGT
AACACCCCAT
ATTATTAACT
ATCATGCGCG,
CAAAATAAAA
TATCAAAACA
GATCAAGGCA
TTGCAAGAAT
GATGTGCAT
CATATGATAA
GTGGATAGAC
GCGCTTATTA
GGCACCGATA
AAGCTCCACC
ATTAAACCCA
GACCCTAAAG
AAATTCGCGT
TTGGATAAAA
?I'GAACAAVI
TrAACCCGCC TGTTTrGGAA 'rrACCTTTGG
TCAACGACGC
GCGACATTAA
TTGATGTGGC
TTTCTAAAAC
CAGAGACT'C
ATGTCGCTAA
CCCCCATTGA
GCTCTGATA
AAGACAAACA
CTGATGTGAT
GcGATACCI' AGT1'TTTTTA
TGGATA.AAC
.TCGGGCATGC
,GGGGGcAAAT
ATTATTCCTC
TACTI TAGC
CTCCAA.ATAC
TAACACGCAG
CAACCAGAAT
TCAAAACGCT
GATGGAGGCG
TCGCGCCGCT
TACCTCCATA
TAGTAATGGG
CCTI'GTGCCT
CAAACTCAT
GGACGCTITA
GCGAGAACTC
TTIGCAAGGC
CTATCAAAAC
TTACGGGAAC
TGAGATTAAA
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 pO/us 96/091Z.2 JPENS 18 DEC 1996
AACCTAACCC
GACGATTTAG
TrTGTAACGG GTGC11'GAAA
AAGTI'CAGCG
GGCGATGAAA
TI'AGATGTGA
A)LTGAAGTGG
AAAGAATCGC
GGTATCCCCA
AAATI'AGAAA
CTIGAGTGAAG
GTGAATGGT
TTGCCTAATG
AAACCCAATG
AGCAACACTG
AAGGAGCGAT
GAAGAGGGTA
cTTTTTrGATA
CTTAAATI'AA
CAATTAGAAA
GATACTTAT
CACTTGAGCG
GAAAACATCA
ACGACCGGCA
AACGCCGTTT
CCGGCAGTGA
ACGCCTTGCG
ATAGGAGTT
TCCCTAGCGT
AGATTTTI'GG
GCGCTATTAA
AAAACTCTAC
ATGTGGAAAT
CTAITTCTIT
CTAATAACGC
GCAATGTTGC
TCTCTAAGGG
CGTTTAGA
GCGT1'AAAAT
AAGTCACTTA
ATCCTGCAAT
TCATTGAAI'
AAGTCATTAT
AAGACGCGAA
ACGCTAATAA
ATAFI'ATCAC
CTAGCGACAT
ATCACATAGA
TCAGGCGTAA
CGGATATGGC
TGGCTTCCAC
AAA TrGGAT
TI'CGAGCGGT
GAGCCAAGTI'
G LTTGTGACT
CGATAAGGTG
AATCCCAAAC
GATTAAAGAT
TGAAACGAAC
TGCCTrAAGC
GAGCGAATAC
CCAAACCGCT
GAGTTTGGAA
AGCGCAAATA
CCCGCTTTAT
CAGGCAGCTC
CTACCAACAA
GTI!AAAACAA
CCAAGACAAC
TGAT'TITCT
CGCCCTAAT1' 'rrCTGTAAGA GCGTAAT?1'A
AAAAATGATC
TGAAGTTTA
AGAA.ACTTAT
GAACAAAATC
TTTCATI'TGA
AAAAGGGTITA
AAAGCGGTGC
AAAGACAATG
GAAACTTI'AA
CTCCCTATTA
TI'GAAAGACG
GGGCGTTTlGA
ACCCTGGATC
CAAAAAACCT
CAAATGAG
AATAGCGTTT
AACTTGGATA
GACCCCACAA
ATGGATGCGA
ATCAGCGATA
GCTAAAGACA
ATGCATI'CAA
CAAAACGCCT
ATTGACAAGC
AAAGGGATT
GGCA~rCAAA
GCTAAAAACG
AAAACACAAG
AACAAGTTTT
AATAATCTGT
'TTTCTAGCGA
CTGAATATGT
CTAACATGTA
TTAGCTAA
AAATCAACGC
AITTGGATAT
CGATTAAAGA
GGATCATI'GA
AAAAAGGGCT
ATTTCAATA6A
CGGCTAATGG
TI'AACATGAA
ATAATGGGGC
CCGCTGATAT
TGAGTATCGC
ACCCTAC'ITC
ACCTTTCTAT
ACACCAAAAT
TACACAGCGA
CAAGCGTGAA
ATCGCCCAGA
ACGGCATCAC
GCGCTCATGG
TTCAAAGCAT
CCAATCTCAC
CT?1'AACGAA
TGGGGA'TT
CAAAAGCGCG
TAACCCTAAA
CAAAAACACC
CAGCCGTTTG
TCCCAI1C T
ACGCTTCAAT
CAA'rrCICT
AGAAGTGGCC
AGAAGGGGCC
CTCTACTAAA
ATTAAACGAT
TTTTrTGAGT
TCAAGCGTCT
GCTCAATTAC
AAAAGAAAGC
TAATI'TGAAT
GCAGTI'CATG
CAAACCAAGC
TTTGAT
CGCTTTAGGG
CCTTATAGAT
TAAGGCAT
TCGTGGGGAA
TAACAACTAT
GTATI'TA
1140 1200 1260 1320 1380 1440 1500 1560 1620 1680 1740 1800 1860 1920 1980 2040 2100 2160 2220 2280 2340 2400 2460 2520 2580 2637 INFORMATION FOR SEQ ID NO:1380: SEQUENCE CHARACTERISTICS: LENGTH: 543 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc_feature LOCATION .543 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1380
AGGATTIGATC
TGTITTAG
AAAAGCTCI'
GATGTGGATG
CGCAGCGATA
AAAGGCGGTA
AATDTCAAACG
ACCTTCACTT
AATCTCATGC
ACA
AAATTAAAAT
GGGCTGTAGA
'rTGTGGAGT'
GCTCTAAAGC
AAGGCGTGGT.
AGGCGTATAA
GGGAVI'TGGA
TGAAACGCGT
GCTC LTTA
TATGAAAMTG
GTTGCCTGGA
TTTrGAGCAT
CAAAAAAGAC
G'FIT1TAAGC T E TrATGAC
ATTCACTTCA
GAGGGGTGCC
CAGGCAGACC
GTGAGTCTT1A
GTTTATCAAA
AACGGGAAGT
AAACTCAATC
GATTTGATI!A
GGCAAGACCT
AGCTATGACA
GAAATCAGTA
CACCTTTTI'
TTGTAGCGTI'
CTCAAGAATT
TCTATGCCTA
CTAACCCAAA
AGGTTGGGGA
ACCATGTGAG
AATGGGGGTA
rITT'AAAGCT
CTATTGGTAA
AGTIWITGT
TTTATACATG
TGGTATI'TCT
GCTAAGGAAT
ACAATCTTAT
AGTCACTCAA
TGTGGGCAAT
CAAGCGTTTT
GGCCTACGCG
INFORMATION FOR SEQ ID NO:1381: ?~1s 18 DEC 1996 972 SEQUENCE
CHARACTERISTICS:
LENGTH: 645 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (geloiC) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1 .645 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1381
AAGGATTI'AA
TGCGCGGCGG
GTGTTTTTGA
TrTTGCGTGG
GGGGCAGTTI'
AAAAAAAAGC
T1'AGGCGTI'A
AGCGCTATGT
GCC ITTTCTT
AACAACCAAA
AGCGTTACTT
GCAAGATGTT
TGGGGGCGCA
TTTGCGCCT'
GGGCTIATTr
TTACCGGATT
AAGTCCAAAC
CCI'ACTCAA
CTTrAACCT GGCTITTAT1'
AAATCITTTAT
TATI'CAGGGA
TGTGGTTTT
ATCCTTGTTI'
GTG!TITTATG
CGCTAAAAAC
TTACGCT TTT
CCCTAAAAAA
TCCTCAAGTG
AGTGCAAAAA
GTTIATGCACC
GGGCGTGAAT
TTTTTTAGCG
ATAGAAGGTT
ATTGTGGAAA
TGCGATATIG
CTTATT1TGA
TTGGCTTI'AA
T'rATCCTTAA TA TTGGAAA
TTCGTCTI'C
ATGTCCTTAC
CTCTTTGTAA
TTATTGAGCA
TTGGTAGC
GGGGGATGGC
TCTAATGAG
GCTTGTTT
AAACCCTTI'
AAAAGACCTI'
TGGTGTTr
TAGCTGGCAC
GCTATGGCTC
CCGCTATCAT
AAACC
GATTTCTTTG
TAGGAATTIAT
CATGGGCGTG
GAATTATTT
TCA.AACCT'T
ATTATTCACT
AATTrGGCGCG
TTTIATCGGCT
TAAACTTI'TG
GGGAACGCTC
120 180 240 300 360 420 480 540 600 645 INFORMATION FOR SEQ ID NO:1382: SEQUENCE CHARACTERISTICS: LENGTH: 720 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE: No (vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY:*misc-feature LOCATION .720 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1382
ATGGATATT
GATGTTTCTT
GGTAAAACCA
TATTTAAACG
GGCTACTTGC
CTAGCAGGGG
CTTGATGCT
CAAAGAAGGC
TAAAAGCAGA
TAGAAGTGAA
CCACCTI'TA
ATGTGGAIT
CCCAAGAATC
AGAGCACTI'
TTAATATCCA
GCGTAGAAAT
GCATITAAAC
AAGCGGCGAA
CATGATATGC
AGCTAAATAC
CAGTATITTI'
TAAAAACTCT
AGCCATAAGA
CGCTAGGGCT
AAACAGArA
GTGGTGGGGC
GGGCTTAG
CCCTTACACA
A).AGAATTGA
AAAGAGAGCG
GAGCGCAAGG
TTAATGAAAA
AAAAAACCAA
TTTrAGGGCC
AGCCTAGTGG
AGcGTTCTAA
GCGTGGAAGA
AAGAAAAAAT
GCATGAGCTT
ACCCTAAAeTT AATCG 171!CA
TAATGGGGCG
GGGGAGCG LT C'rrGGGCATA GAA 'ITGGCC
GGAAAGCTTG
GAGTGGGGGA
CGTGcTGTTA 120 180 240 300 360 420 480 C 4, PCfi 9 6 /09 12Z2.
1PEANJS 18 DEC 1996 973 GATGAGCCT TTGCGGGCGT GGATCCGATT
GCGGTGATI'G
AGCTI'GA?1G GArrrAAACAT TGGCGTGTI'G
ATTACTGATC
AGCGTGTGCC ATAGGGCGTA TGTGATCAAA
AGCGGCACGC
AATGAAATTI' ATGAAA.ACGC TITGGTGCGT
AAGTMTTAT
ACAT~cAAAG
ACAATGTGCG
T ITTAGCGAG
TAGGGGAAAA
AATCATTGAA
AGAGACCTTG
CGGGAACGCT
TTTTAAGGTA
540 600 660 720 INFORMATION FOR SEQ ID NO:1383: SEQUENCE
CHARACTERISTICS:
LENGTH: 240 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1.._240 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1383 AACACTGGTT TGTGGCACTC TTGGGGTITTG
GCTCCAGCGC
AAACATGCTC ACCAATTITT TCAAATCTTC! TTTrTCCCCA ATCGTTATTG TGGAGTIGCT TGTCAA7rT
ATCTIAATC
GGGGTTAAAA TGATAGATAA TATCAAACTC
CCACTTAGAC
'ITTTGGAAAC
AAAAGCCCTI
TCTTTICACGC
GCATAAAAAT
GCAACTGCCC
CAAACAAATG
CATACATGI'
GCGCGCTCTC
120 180 240 INFORMATION FOR SEQ ID NO:1384: SEQUENCE CHARACTERISTICS: LENGTH: 1644 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1 .1644 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1384 ATTGATCTAG
GCOTGATAGA
GCGTI'GATA
GTTTAAAAGA
AAA'ITTGAAG
CCACTAGCAC
CTCAATAACA
'FTA)AACAAA
,AACAC?1'GTC
CTTACAATAA
CC4CAAACCG
CAGAAGAATT
CAATCI'GGG
GCGATGCGAT
GACCATCCCC
GGCGITTGAT
TTCTATrCT
TCTTATAATG
TAATGGTAAT
CACCAAI'TA
CTTAAACGCT
AAACACTCTA AGATGTITT AA.AATTGACC
CCTATACTT
GATACTAACA
CGCAGAGGGT
AAATATAGTA
ATGAAAATCC
ACAAAAAATG, AI'GTTGGCA ATGI'GAACA
TGATCGCTGT
CCTTTTGAAT TCACTAACAG
ACCCGGGGAG
CTTTTTCCA
GTITIGAAACG
AAACAATTTC
AAAfITTCACC
TTTAGACTCC
CTCAACAGAT
120 180 240 300 360 420 A M i 1"o PCT/IS 9 61O 912Z2a IPENIJS 18 DEC 1996
TGCGATAGCG
GTCGATCAAC
GAAATTGATG
AIATGATGGTG
TTTGGCAACG
AGCCACACTA
AAAGATGGTC
TATAATGTGT
AATI'CCATCT
GT1'rGGCAGC
CAAACAAACT
AGCACCATCC
TCGCAAAGT
'ITTAATGAT1'
G'ITAATCAAPA
ATCAccACVI' TcATcITTTTG
AAAGTCAAAG
TCTAAATAT
AGCGGTGGCG
TTTTTCAATT
ATCCTI'CAAA ATGCG A74TATATACT CAACA CGGTTGTrIT
AAAAA
AATATGGCAC
ATI'AG
ACCTTAAGAC
TATCA
AAGGCTATGG GCATA AAGTGGAAAA GGATA GTTCGCTI'A
TGGGG
ATCACAATTG
TGCG
AGCTCATCAA
TCAAA
ACAACCTAAA
CGCTA
AAAAAACCT
TGTAA
TrAGAAGCCCTAI TCATAGGGTT
GGCT
AAGTCCAGCA
ATTG~
ACTCCAATAA AAAT' GTATCTrTGGGGG GAAGCGGCAA TTTAC CTGTAGGGAT
TAGC
AT1'ATACGAA
CTCT
ACGGGTGGGT
G'TTT
TAAAT
A.ACAA
ATCA
GGTA
ATTTA
ACGGG
GTAAT
GATTC
ATGTC
CGCC
.G'TTA
CTTCT
TrAGGG
'ATTAT
LGCTAT
LGCCT
7.TAAGG
;ATGTG
TCCCT
MTTGTT
CCCGGAGTAA
GGTATTATTA
GGGGTI'GTAG
GAAGCCTATG
GAAGATTI'AA
AATATGACCT
GGCAAGCCAA
AATCAGCCCG
ccGGCTGGCT TTGccGATCA
AACACGCAAG
AGCGTITACCA
GTTAACGCTA
GGcATCATCA GGTrGGGGGGA
ACAGGCATTC
GGCTTGTATA
GCTACCGGGT
TTAATCCAAA
TI'CAATGAAG
ATGGGCGTGT
ATAAT ITTAG
GGTTAGCCAA
CTTTAGATCC
GAACCATCTT
ATCAAAGAGT
AAGATTCTGA
CITrCCCTAG TI'rAGGGGT
ACTACGCTAA
ATTTAGCCAA
ACCACCATTT
AAATAGGCTA
AATACAATTA
TAGATTTGT'
AAACCAAAAG
ACAGCTAT'A
TGAACTACCG
GAAAAGCTAG
GGGCTAGCCA
TGATACTAAA
AAAAAAAATA
TGGATATGGC
TAAAAAACTC
GCATGAATITC
GCCGGTAACG
TGGCCTrCCC
CAACTACCCT
AACAGCAGCG
C'rrGGGGAGT
TTCCATGCTC
TTcAAACGCA
TCAAAACTAC
CGCTAAAGCT
ATI'GGATFI'C
GAATTTTCT
ITGGTTGAAC
CTATAAGCAT
CGTCGTCT
CTTTAAGGTG
480 540 600 660 720 780 840 900 960 1020 1080 1140 1200 1260 1320 1380 1440 1500 1560 1620 1644 INFORMATION FOR SEQ ID NO:13 85 SEQUENCE
CHARACTERISTICS:
LENGTH: 1260 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .1260 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1385 GATCATAGCT 'rrAATATTCA ATITAAACCCA TAAAAGCCCC GCGTCCATI!A
GGCGCTGGA.A
CAAGCCCATA
AAGCGATGAT
GATTTIAGAT1'
TAGATCTIT
TTAACCGATA
TTAAACCCCC'
GCI'CCTATG
TTGCGCAAAG
CTCAAAGAGT
ATTTAAGCCA
CATTTATG
CGTCTAAGTG
GGCGTGAAAG
AGAITAAAGA
GAA GGG CT TTGGGGAAAA CGTTTCCAAA
AGCGCTGGAG
ACTTTATGCG
TGGCOATTAT
ATGCGGATCA ATCATr1'TTr GACATTATCA
CGCCCATCAA
GAAAAAAAGG
AAATGCAAAA
TTGAATTTTCACCGAAAA
GTTT1CACTA
AAGACGCTGA
GT1'TGCGGGG
AGCTTTTGAA
LAATAGTATA
CAAACTCAAA
rGACCAAGCA
TGCGTATCTG
PLATCAAPLTAT
TArrrrlTrAC TTrGCAAGAT
CAGGCCTCAA
GGAGTTTGAT
TAAAATTGAC
AGAAGATI'TG
CCAXACCCCA
GGGGTAT'IA
GGGCGGGCTI
ACAAAGCGTI
CAAAGTCTAT
CGAGTT'AAP
AGAAI'ATTC
GGTGTGCGA1 AAAAGGAAAG
TCATGTATGC
TCTCAA?1rr TAAGGCGTGTC TGCCCTI'TGG
AAWTGTGGA
CTCGCTAAAG, AT1TAAAGA ITTTGCTITG AGT'T1TGGA GCCCTCCAAC AAACGCATAG GAAATCAGTG
CGTATITC
ATITTTAGAAA CTCAAATITrr ATTATCTATC ATrrrAACCC AAGCAACTCC
ACAATAACGA
AAAAAATTGG
TGAGCATGTT
AGAGTGCCAC
AAACCAGTGT
TTGAGTI TG ACTI'GAAAGC TrCCATGATr TACCCGAAAT GCAGGGCTTG ATCATI'GCAT TCCTTTGTGT
CTI'TGGGCGT
AACCGCTACA
AAGACAAGTC
ACGCTTTATA
ATAGCGATGA
SCATTTGAGCG
CGTI'TTAGA
;GCTCATCCT
ITTTTGGGC
=TAGACAAG
VAGGGGTAAA.
;CGCTTGGTT
rAAAGAGT1TA rrITAGAGGAA
AGAGAGCGCG
CAACATGTAT
TCATTTGTr
TGGGCAGTTG
TCTAGGGCAT
TrGTAAAAGC
TTTAACCCGA
TAAAGAGAT
TCAAGAAGAT
TCATCAAATC
ATATCTTGGG3
AGCCCAAATC
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1140 PGTI'' 919R2 1PEAIUS 18DJEC1996 TCTCTTTCTC ATGGCATTTC TAGCTACGAT TI'AATCCAAG
GAGCTAAAAA
TTGCGATCCC AACGGAACT GCTI'GATT1'G GATTTAGA
AATI'GTI'TAG
CC TrrAGAA
AGATITTTAAG
1200 1260 INFORMATION FOR SEQ ID NO:138 6 SEQUENCE
CHARACTERISTICS:
LENGTH: 804 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .804 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1386
AATATTACAA
AAAAAATGCT
ATI'GAAACCA
GCGTTAGATG
AAAGAGTATG
AATCAGGGCT
CAAAAAAAAG
CCTAAAAGGA
AAAATGGAAA
AGTGGGGAAT
TTCTTAAAAA
AcGGATAATT
CAAGAAATGG,
GAATTAAAAA
TCAAGGATAG
TTTTAGGCGC
ATGAAGTTGC!
AAAAGAvrTTr
~AAACAAATT
ATAAGGT1'AT
AAGGGTATIT
CCATACAGAA
GGGTTTrrAAT
CI'TGGAI'C
CCACCCATT
CTAATGACGC
ATAAGAAACT
ACAAGAGAAP.
AACGATGAAA AcAAATGGTC ATTTTAAGGA GAGCrGTGGTG GcIrTATTAG
TGGGGTGTAG
'ITGAAATTG AATrACCATC
CAGCTAGCGA
ACTITI'AAGG CcGTTC
AATACAGCGA
CAAGAATCAA ACCACGCTTA
AAGTI'GAAGA
TAATGTGGAT AGCAGCGATA
AAGACGATTT
GGCTGTCGCT ATGAATGGCG AAATl'GTITl' AAAATCAGAA CCCGGGTTAT
TATTCTCCAC
CCCGGCTGGG rrrGTCAAGG T1-ACCATACT ?1-rTACGATG GATTTGAGCG
AGI'GGACAT
AAGCCATAGC GGAGGG1 'AG TrAGCACTAT AATTAAGAGC GCTI1GAATA
AGATITTTTGC
CACTCAAAGG AATTTAGAAT
CTIATCAAAA
CCGA
'TTTTGCATGG
CCCGcATT
GAAAGTTCAA
TAATATTGCT
GATCTTGCAA
Tl'C'T1TGCG
ACGCCCCGAT
TGGTI'GGAT
AAAGCCTATG
CCAAGAAAAA
GGTTAAGGGG
AAGTATCATG,
AGACGCCAAG
120 180, 240 300 360 420 480 540 600 660 720 780 804 INFORMATION FOR SEQ ID NO:1387: Ci) SEQUENCE
CHARACTERISTICS:
LENGTH: 300 base pairs TYPE: nucleic acid STRANDEDNESS: double CD) TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .300 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1387 P l '41 2. 0S @912 2 IPENUJS 18 DEC 1996 TCAAAT1'TTA AAAAAGGAT1' GGGATTITTAG GGGTrAGT TTGCAACATG ATCATTATCT ATAGAAGAAG CTTGAAAAA TGCTCGGCTG CTATGAGAAT
'TI'TATGTTT
GGTGGm-rrT
ATCACAAGTG
GGATAGCGAA
AGCTGCTGGT
AAAAGCAGAT
TGGGATGTCA
AAAGAAAGGG
TGCTTGAAA.
GAAAGAAATA
TAAATTCATG
TAAAATACAA
AAGAATATI'A
AAGGAGGCGA
GAAGAATGTT
AATAGAAGAT
TAAAAACCAC
TAAAGTGGAT
AGAGATTAAA
INFORMATION FOR SEQ ID NO:1388: SEQUENCE CHARACTERISTICS: LENGTH: 726 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .726 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1388 AAAI'ATITT TAGTTATAAT CATTTCAAAA ATGATATTAC CTAGAGCAAT ACAAAGAAAA ?TAGAAATI'T ATTTACGCAA TGGGTGTTTA ACGAAAGCGT GAAATCACGC ATTCTTTAAT TTGTrATA AGTTAGAGGG TACCCCAATA ATAAAAATGC TCAAAGGT'TC ATATI'GCTI'I GAAAATFI'AC TCAAAATCCA TTAAAAGACA ATGATAGGGC TT1TCAAAAA ACCTTAAGAG GCTCATTCTA TCTAAAGACA 'rrTAAAACTC ATTGCTTTCA CGCTTTAGAC TATTGCCTGA TTTrAACCCCT TTAATCAAAG CTTATCTAAA ATGTCTTTAG GGTAATATITA GATTTAAAQC ATTATITATC AACAATAAGA AAACTTGCTA TGGACAATTA ACCGAACAAG CGCCCACGCA AAGAATTCCT ATGAATATCA
AAATCATGCA
GATI'AGATAC
TCACGCCTAA
CTCAAATGAA
AATTAAAAGA
GGGCAGTGAT
GCATCAATTrr
AA)ATCCAT
GAAATCGTGC
TTACGACT1TA
GTGTAGAACC
AGATTTACAA
TTATGACAGC
AATTTCTAAC
AGGGAGTGAA
AAAGAAAAAA
CAGGCTTATT
CAAATCCTAT
ATCTAGTGCT
GTATCAT'GG
'rrrCATTGGG
AAGTAAAATC
AGATTTAAGT
120 180 240 300 360 420 480 540 600 660 720 726 GTCTGT TAGATGATI'T AATI'AAAAGC ATCGGAAATA AAGACTTGGA AGTI 'G INFORMATION FOR SEQ ID NO:1389: SEQUENCE CHARACTERISTICS: LENGTH: 1401 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc_feature POUS 9 6IO 091 z ipuvaJ i8 DEC 1996 977 LOCATION .1401 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1389
GGCATGAAAG
'ITAAACCACT
GGTGCTAAAA
AGGATCAAGC
AAAGTGAATG
CCCAATCCCA
ACTGAAAGGA
CGCATCTCTG
GAGAAAAACT
CTAAAGGATT
GCTGGACFI'A
GCGGCTAAAA
TATACGGCTI'
AATGTGTATG
ATGGATAATG
TATTGCAAGA
AATCGCTI'AA
AAAAAAGGTG
AGCGTAGAAA
ITAATGGTGC
ATrCCTGCTG
CAAGAAATAG
GTAGGAAAGG
ATCCAGTCGT
CGTI'GAAGAC
TAAACGCTGT
GAGCATGGGA
TCGCTCAAGA
ATGTTTTGAA
TGcAGTATGT
TCAAAGAAAA
AAAAArrGCCC
TACACCAATT
TTGCTAACGC
GAGGCAGAGC
AAATCCAATT
ATGAAAAACT
CGAAAGTCAA
AGTTGGGCGT
AAGAAAACAG
AAGCGCAAI'
AAGCAGCCGC
CTGCTrAGA
AAATGCAAAG
ACGCCCTAAA
AGAAAGTCTA
CAAGTGGCGT
TI'AATCCGTA
TrrrrrAAAA
GGCTATGAT
TGAAAGCAAG
CACATTAGAT
CAAAACCAAT
AGAAAAAATC
TCCACAAAAC
TGAACTCAAT
ITTrCACGAGC
CATAGGTAAC
CTTATIAGAA
A?1'AGACAGC
TAGAGCTGAA
ACAGCTTGTT
TAAAAC IlFI
AAATGGCAAA
TGATGAGCTT
TAAAGTGTTC
AATCGCTCAA
CTATGCATTC
AGATGACAAA
TAGGGCTAAA
GAATTCAAAT
T
AAATCCCTTA
GTGGATAATC
TGGGCTAAAC
AGGGCTAATC
cAATTTCTAA CAAAGT1TI'G
TAT'GATATAC
TGGGATGTCA
AAGGGGAAAG
ACTCAAATCA
TACATTTGCA
CAAATGACI'
AAAGAAGAAT
GTAGCTI'CCC
GGGTTCAACG
AGCGAGTGCA
AATrI'AGAT
AATGACTACA
AATTrAAGTT
AAGCAACAAA
GAGCATCAAG
TI'AGACGCT
AGTAATAATG
'rrCTGTTACT
CTACGCAGAA
ATITAGCCAC
AGACGCTI'AA
CAGGCAGTAT
CCAAGCAAGT
GCAATCAAAT
GTCAAGACGC
AAAGCGCTAA
GCACGGCGAA
TI'CAAAAAGG
TAGCTCTACT
TAAAAAGACA
AAGATAGAGC
ATGAGAATGT
TCCCTAACAT
ATAGTAGGGA
AACACCGATT
?I'ATGAATAA
TGGGCTATT
AAAATCTTGA
ATGG'ITTCCC
AAGCCCCAAG
AGCAATTGCC
CGCTTGGAAT
TAITACTGAA
T'TCCATCAAC
T1'TAAGCATC
TCAAGCCAAT
TGCAGCCAAA
GAGCCCTACA
CACAAAGGCT
CGATTITAGGA
CAATTTAGAA
CAATAACGAC
AATCGCTTCA
G ETTAOTCAA
TAAAAAAGGT
GCTCAATGTT
TATTGCTGGT
CCAACAATTA
GACGCTAGGT
TGAAGATATT
ACAAAAACAA
TAATGGTAGT
CTCTGATAAT
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1140 1200 1260 1320 1380 1401 INFORMATION FOR SEQ ID NO:1390: SEQUENCE CHARACTERISTICS: LENGTH: 1272 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .1272 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1390
AGATI'AAATA
CTI'CGTGCTT
TTAGTTGTCC
AGCAAGATCT
GTTTTAGGAA
TTTGAAATCA
TATGCTITA
AATCATGTAA
GTGGTTAAGG
AGTATCACTA
CTATATGAAG
TI'GTI'ATTAG
ACATGGCCGC
TAGCTGTCAT
AAGCAGATG
TGAAAGGAAT
TGCTITTAAT
AAACCTIWII
AATCTGATGG
CAGAAA TT
AATATCAAAC
ACGCTAATAT
ACTTCAAAAT
TTATTTTAGG
TCCACTACTT
AGGAGTGGGT
GCTI'ATAGT
TGGTGAGCCT
CCTITTGTAT
AATGCTTTT7.
TTCTAGTAGC
TGACACGCCT
AAATAGTGCA.
ITCATTCCAT
TAATAATGGA
ATTAGAAITG
GCTCTGCCCT
GCTTACTN'GT
GAAATTCTTG
TTAGCCA.ATG
TCCTI'TA.AAC
GTGTTTGTAG
GGTAATGGTC
GCTAACTI'GC
AGAGAACACA
GTCAGACAAA
CTATCGCTAA
TTTTTATTGT
TTCTTTCTAA
ATCCCAATAA
GGTTTTTCAT
TTATCCAACC
GCTATCAAAA
GATACC'TI'C
GCTCCAG TI'
TAAATGCTGG
AGAATATAGA
TTTTAACGAG
MACCCITAT
TCAAAG 3:17 CCCT1'TAGTG
GCAAGATTCT
TTCGTIT'CT
'rl m rlGGTATG
CAATGATTTA.
TTTGTACCAT
TGCCTITDCAA
GATTTCTAAT
CACGCACCAC
TTGAATAAA
TGCAGCTGTT
CTGTTATGTT
120 180 240 300 360 420 480 540 600 660 720 ama qwvv. Pfl 0-- IPENUS .8 DEC 1996 978 TPI'ATGACT1' ATTTAGAAAA GGGTITTTC AGCAGACTAG ACTTITACA TGCCTrI'GTI' GCAATCAAAG TGGGAGGGAG GGAAI TCAC TGACATFTAT CAAGGTGGTC TAACGGATGC GGAGCTGGAG
CCATAGCTGG
CTAGAAGCTT1
ATAAAGACGC
ATGCCAGGAC
ATCCTGGTGT
AGAGCTAGCA AA
AATTATTTAC
AGGTTITA
GTTGCTATTA
CAATGAAATA
TCAAAAAGTC
TAAAAGCTTC
AAGTCTTAAG
AAAATCTACG
TAGAGTGGGT
TTGTCTTTGG
GTGTCTTATG
GTGTTATTCA
GTGGCTAAAT
CCCGAAATGA
ATATATCAAG
AGTGTGGGTC
ATAAACAGCA
GTGGAGACGA
TI'ATTTTCAT
TGAAAAAAAT
ACTCTTTTC
ITGGCA 'AT
TTAACGCTAT
GTGTGCAAAT
GTTCAGCAT'r
CTACGGCTKA
TTGAACTTCC
GCTACTGCTA
TATI 'CAT'G A?1'ACAATAC
TGTAGCAATA
CTTTGGCACA
GGCTAGTGCT
TGGTAGAACG
CATGAGAGAC
CAAGTCTCAT
780 840 900 960 1020 1080 1140 1200 1260 1272 INFORMATION FOR SEQ ID NO:1391: SEQUENCE CHARACTERISTICS: LENGTH: 1152 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc-feature LOCATION .1152 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1391
AAAAATCGCT
AA.ACATGCCG
CAAACCTCCC
ETCACGCAAC
ATCAGCT1TGC
AGGGATGTGA
TCATTCTTT
GGTAACCCCT
ATGGGCGGGT
IT AAGTTTIG
AATAAGCCTT
ACCCAATACC
CCTAATACCT
ATGGCGTI'TA
ACTGATTGGC
CTCAATTTAA
AAAGAACT'I'I
GATAAAGCGA
GTCTATACT'
ATCTI'AAGAG
CCTITIVITGT
CCTATGCTTT
TCACTATCCC
CTAACGACAA
AAATCAGCGC
TAACCAAAGA
TGcTTTITr
GGGCCACTTC
CGCGAAAACT
TAAACACCAC
CCTTGTTGTT
TAAACCACCA
GAAACCATTC
AAAAACCCAT
ATGGAATATT
GGCTTTCTA.A
ATGAAGTGAG
ACAACCGCTC
GGGGCGAAAC
GGGGCTITTT
CACGCATAAT
TAAACCAAAT
TCTTTTGAGC
GAATCTTT
AGAGCTTCT
GCATGATAAT
TAAkAATCTAT
CTCITTTAAGC
TGATGGCGGG
GAAATL GAC
GCTCCAACCA
'TTAAAGAT
TI'CTACAAAT
GTATTTGATC
ATTAGAAAAC
TTACCCAAGC
TCATATCAAA
GCTATCTI'GG
ATCGTTI'GT
CAAGCCCTTG
GACGCTTTAA
GCTTATTTTA
GACAGCAAGA
CATCATTCGC
AAAATI'rrGT CAAT'rTGAAA
CCTTTTAA
TTTrATGCTAC
CAACAAAATA
AGCI'AACCC
AGCCTCATGC
C'rTAAAAACT
CACAACCCTA
TCCAACTCGT
AACCTTCAAG
TITTAATTAT
TCACTCAAAC
GCGCGCATGC
GCGGCACTAA.
CTAATCGCTG
ATGAATACAT
TGTTTGTCGT
GCGCTTTAGA
ATTI'GAGCCA
CACTCTATCA
ACCCAAGAGA
CCTTTrAAAGA
TAGAAACCTG
TAGATGATTC
GCGATTTATC
TTAAAACCTT
~AATCGCCTA
ATG AAGCAC
CCCCCCCTAT
GAGCTCTI'TA
A.GAAGGGGCA
GAGCGAAGCC
CAAAAAATTA
AGGGGTGAGC
GCCGATTCAT
TTTAGTAAGG
CGAATI'AGCC
GCT1?rAAGG
CTGCGCTGTC
TAAAACCCCC
T1'TAAATTTA
ACTGCGTCGT
AAAAGTTTG
TATAGATATT
T1TATTTAAAT 120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1140 1152 TATAGCCTITA ATCCGCATTT CACATCCGTT
TCAATATGGC
TCCCTTCTCA AG INFORMATION FOR SEQ ID NO:1392: SEQUENCE CHARACTERISTICS: LENGTH: 555 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular )/09122 iPEAAJS 18 DEC 1996 979 (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .555 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1392
TI'AGTCATGT
TTII7TI'CA
TTAAGCAATA
GCCCCCITAA
ATACTCAAAA
CTGTTGCTTI'
GCTTCTCTGA
GGCGTGATCG
TTAGATTCTT
TTATATCTIC
AAAATAAGCC
TCGCTI'GAA
GCCCCTTI'AG
AGCCCCCTT
TGACAGATAT
TTI'AGCGC
CT TAGTGGC
TATI'GGATTT
TTCTTACACG
ATrGGGTTTG
AGACTCCCTA
CTGTCITTTG
AGAAACCTTG
TTTAGGG TI'
GCTTTTGC
Trl'ATCCAGT
CCCATI'ATT
CTGAGTI'TG
AGGTTI'CGC
TCGCTCAATG
ATCCTTGCTI'
CAATCI'ATA
TTGCCTITI'T
AGCAGTTTGT
TCGCI'TIGA
cTTTTTGTCT
TATGGCITI'T
TCTCTTTGAT
AATTTTTAAG
ATGCAAGCTT
GCGTCATGCT
CAATCTACCA
T TTGAGTAG,
TGCGTTCTAA
TTITTAAGAC
~TAATrrITC
AAGCGTGAT
CAGTITACA
TTCTTGCCAT
GTTTTTCAAT
TCATTITCATG
CCCCTTATTIA
TTTTCAAATC
TTTATATCT'I'
120 180 240 300 360 420 480 540 555 GCTAAAAAAA GGTTA INFORMATION FOR SEQ ID NO:1393: SEQUENCE CHARACTERISTICS: LENGTH: 2946 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .2946 (xi) SEQUENCE DESCRIPTION: SEQ ID, NO:1393
AAAAGAATAC
CACATACAAA
AACAAGCTTT
ACTAAAAAGC
GTGTCTTAT'
AATATCTTT
TCCCTAGAAG
AAAGTCCAAG
TTGATI'GTCA
TTAAAAACCA
CCTCTTI'CC
TITGCCAGCT
ATCCCATCGC
TTTAATGATG
TGATGAAGAA
CAGTATITCAC
AITI'AAAAAT
CITTGGAAGT
G TI'AGAAGT
TTGAAAAACT
TTGATGGGAA
ACGATAAAAA
TGGATGGCAA
AGCCC'ITAGT
TAGAATTAAA
AACGCCAATC
TTAAGATTGA
?TI'GGAAAA.
GCTTATCGCC
AAGAAAACAT
TCTTTTAGTC
TGGAAA.ACTT
TGAGCGGGT'
TI'CTGA TI'G
TAAAGTCAAA
TAAATACGAG
TATCAAGCTT
CGCCCACTAT
TGAACCCAGC
AATTAACACT
GCAAAAAAAT
TAACGCTTI'A
TTCTGTAGT
CATTAAAATG
GTATCCAAGA
GTCATTCACA
GGCATTTCTG
GATCTCTCTT
AI'AAAAATA
GAAATCA7I'T
TTAGAATTTC
AAAATCATCA
TCACCCAAAG
GCTGCAATTI'
TCTCCAATGA
TTAAAAACGT
ATCAAGGCTA
AAAGCCACTT
GATAAAACCG
AAGTGTTTAA TGTCATTATC AAACCCTTTC AAACGGCATT AA'rrATACTT AAAACTCAAT
CTITCTTCCA
TCCGTTATGG
TAGACGATAA
CAGGAATCAA
ATTTGCTTTT
CCAGGAAAAT
ATTI'GCAAGG
AAAGCCTAGC
GGATTTT'GA
A'ITTCACTCC
TGATTAAGCC
AATTGATTr
TCAAAAACCC
cATTTGGGCG
AAATAAAGCC
AGGGGAAT
TAAAGATGT'
GGCGTTCAAT
GCTAACCGAT
GTTTTTAAAG
CAAGATCCAA
TAGCGAGT
TTCAGTCGT1'
CAAAAACAAA
120 180 240 300 360 420 480 540 600 660 720 780 840 900 p 7..G12 )PENIUS 18IJEC 1996
CAGCTCCTCA
GCCACTI'T
AATTATTATG
GATAAAATCA
ACCGCCCCCT
TATAATATCC
CAATACATCT
AAAATCGCFI'
CAAGTCAATA
GATCCGCAAA
GAAAATTCAG
AAATTCACTA
TGATTr
GAATTTAAAG
TCccccATTA
TTTGTCAATA
GATGGATCGC
GTCTATAcTC CTrAATAACA
GGATTATTCT
GTTCATTA
CGCATCCATG
CTTGATATTG
ATCATGGCGG
TATATCAACA
GCTCTI'GAAG
TTCGCCCTCA
AGAAACCCTC
ATCACTAAAG
GCTGGCAATG
ACTATCAAGG
GGAAAAGGAG
ACCCAAGTAA
'rrCACGCCTA
TTAAAA
TACAGCCCCA
CC AATrrGTrr
GCGATAGCAT
GCATGCCATC
TATTI'AGCGT
ACATAGACAC
TAGAT'ZTAGG
CCAATAACAA
CTAAC?1'TAC
AAGTITTTAG
AAGATGTTT
CCAACCCCGA
ATAACGCCTA
TGGACTATAT
TGATTITT1 ATTTT1GAT1 C
CAAGCAAAAG
TTGATTI'GAG
CAAAAGAACG
GCGCcAAACA
CTAAAGATGT
TCGCTCAAGA
A?1'TAGTGCA CcATI'CTICA ATCAGGTTTTr
TGCAAAACAT
ATTTAGGGGC
AATATTTAGG
GAATCATTGA
CT'rTGAGTAA
GTAAAATCAC
CTTTAGCGTC
,TTGACATCAI
AAAAATCACT
AGAAGCCCCT
TAAGGATITA
TAGcGCGGAT
TCAAGGCAGC
GcAAAGCGCT
GATCCACACG
TCAAAAAAAC
TATCAACATG
TTTGGATCTA
AAGAAAAATC
TTACGCCACA
TCACATACAA
TACTTTTAAG
TGCCCTAAAA
TGCTAAAGAT
'rrrITCTTTA
CATATCCATA
TATTGATGAT
AAAAGAAAAG
ACGCTATGAA
CGTGCTGATC
cGATAGGGTG
TGGGGCTTG
AAA.AGAT1'TC
CAATGGCGAA
GGTCAATCTC
TAATGGCTAT
GTTAGAAAAA
*A'rrAGACAAA
TGTCTTAAAT
cACTAACGTrG
AGATATTATC
7CGTGGATGAA
TATGAAACCA'
AAGTTGGAGG
TTGAGCGCTT
TTGAAGCTCA
GTI'AATI GC cAAATCAATT cGCTATGCAA C ITTCTTTGG CGCTC 'ATG
AAAAGCTTGC
ATAGACACCA
GGAGACACTC
TGGAGCGTGC
ATcAAAGATI'
GACGGCTCTI'
TrGAAAATCA TTrGGCTCTA
AAAGTI'AAGG
?TCTTGGATA
CCTAGCTCTA
AAAGCCCACA
TATAAAAAAA
AAAATTGATG3
TATCTTAAGG
GTAGAAGGAG
TT-GAAATcC
ATCAACACCA
CAAATCAAAA
ATTGATCI'G
AACAAATI!AG
AAAATCCCTA
AATGTCAAAG
cAAGCGCCTT
GTCAAGAAA
rGGAATTIAAC rrTTTTTAAA
ATAAAGTCGT'
cTTTGCAAT
AAGAAGGCAC
TGGACATCGC
ACATGCTGGA
AT]TTTAGT
ATCCCAATAA
ATTCTATCAT
TTAAAGCCCA
TCAAAAGCCT
CACAACTCTI'
TGAAAAAGAT
TAGAGGTTTC
ACCTCCCCAT
TcALATAAAGA
GGGATCAAAA
GTAAAATGCC
AAGAAATCCA
AAATTATCCC
TGccTTCC
GCAATI!ATAA
CTCATAA'TI'
GCI'AT1CAC
AAAACACAAG
TT'CCCTCCCT
CCGGCTCCGT
TCGGCAAAAC
ATTTAAACTT
TCGTGGGCTA
GCACGTIGGA
TTAAAATCTT
ACA'FIGA'rrC
:GGCTCTTAC
kACGACCCCT M ACCTTTG CT'rAAAAAAC r'rrCTCGCTC
:CAAGAATAC
rTTAGACGCT
CCATAAAATC
CACTCAAGAA
I'CAAGAGGGT
AAGCGAAGAT
GTCGTTCAGT
AT'AGAAGGC
CAAGCCCTAT
TACGAGCGAT
T1'ATAGGAGC
TGAAATTTCT
GGATATTACC
AGcTATrGCG
AGATGAAGAT
CATCTCTACA
TTTAGAAAAT
AAACGCCATG
TAGCGGGGAT
GCTTATTGGG
CTTAAAGAAT
TATGTCT1'
TGTGTTTGGG
GCTTGATATI
AGAAGTdC
TCTCGTTTA
TAAGCCTAAA
ACGCcGTATI'
AAAAAGGAAA
960 1020 1080 1140 1200 1260 1320 1380 1440 1500 1560 1620 1680 1740 1800 1860 1920 1980 2040 2100 2160 2220 2280 2340 2400 2460 2520 2580 2640 2700 2760 2820 2880 2940 2946 INFORMATION FOR SEQ ID NO:1394: SEQUENCE CHARACTERISTICS: LENGTH: 1113 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) AN~TI-SENSE:
NO
(vi) ORIGINAL
SOURCE:
(A).ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .1113 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1394
AGACCATTCA
TTAGAGTGCG
ATAGACGCCC
AGCGAACCTT
CCAATCACCC
GATCGCI'AT
TTATTACT'G
ACTTGCATGT
TTAGCGCCGC
TAGAATATGA
AAGGATTACC
GGAGGCAAI'
GCGAGAAAAC
AGTGATCATG
AGAAGAAATI
CACGCCCCAA
AACAGCATGG
GCGcTTTTAA
CCCAATCTCA
TTAAAAAATT
AACTAAAACC
AAATCACGCT
AAGCGGTGTT
GTAAGCCVTT
cTTcAAAcI'
CTCA'FTCGCA
.ITTTGACCCC
GGAATAT1'CT
GATTOACACT
CAAGCCTTA
Y7 P0K 9/091a2.
IPENIUS 1.8DEC 1996
ATGAGTTTGT
GGCATI'AAAT
TCGGATTTGT
AITITATGCG
AGCG TI'AG
AGCGATTGGC
TTACACCATA
TITTGCAAAC
AAAGCCCACC
CATAGCGCTA
GAACTIITG
AAAAAAATCT
TTTATAGTCC
GAAACGCTAT
AT=~AACGA
TTTAAAACT
TGGGTGAAAA
TCCATGCAGA
AAACTTTCGC
GCAGTATCGC
TCAGCATGAC
CCTTAATCAA
CTAAAATCTC
ACATCCCGGC
AAAA.ACACAA
ACGCGCTAGA
CTACGCACAC
CTTGGAACCT
TGGTITGACT
cTACCCCAAA
GACTTTGGAG
ACAAGCT(GG
CC TI'CATI'C TI GATTGAA
TITAGATGAC
AACCAAAAAA
T'I'TTGGATCG
GGGCATCTT
CGCTTTAGAA
CAATr'IACCC
GCTTTGCTTG
TCAAGAAATC
TI'AGAAGAAT
GGCATGACCA
GTTTTIAGAAA
rrFTTGIWIGG
CCTAAACTCA
AAGCATGACA
TrATTAGGGG
GACCAAGAAA
GACAGTGCCC
TCTGCCCCTA
AATTTGCAAG
AGTAAAAAAG
AATGAAAAAA
GCC
TGCAACGAGC
CAAACGCGCA
ACGCCCAAAA
ATAAAGAATT
AAATCATTAT
ACCTCTATGC
GGAGTTTGGA
GGCTC'ITATC
CGCATTTCAT
TTlTTGTTGCC
CCTTATCAG
CGCXTTGTC
TCGCTATCTT
TAAAAACAAA
AAATGGCACT
AI'AGGCTT
TATGCCAT
AGAGCATI G
GACTTTGACC
CCCGCATITGT
CCTrGC ITrA
'FTCTAAAAAG
TGCGI'GTGC
TGATAACGCT
TAAAAAACCC
AAGAGGGGGC
360 420 480 540 600 660 720 780 840 900 960 1020 1080 1113 INFORMATION FOR SEQ ID NO:1395: SEQUENCE CHARACTERISTICS: LENGTH: 693 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1 .693 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1395
GAAATATA
CCTGTGGATC
TGGTTGATT
GTTAAATTAA
AAAA.ACAACC
CCCACACCCC
AAACCAAAGC
GTGGAAAAAG
GAACAAAAAG
CCTAACCAGC
GGCTTGGATA
T1TAGGCACAG
TGCCGGAAAA
ATTCTAACAG
ATTTTAT
ATCCTGAAAA
CAGGCGCTCC
CCACTCCGCC
CCAAACCAGA
TGGAAGACAA
TAGAGCAGAA
TTrCTrrCTT
ACCAGACTAG
CCCGAAAAAG
TCTAAACTA
GAATTITC
TGAACACAGA
TTTATTGGTT
TAAACCCACG
AACCCCACCA
ACCCAAAAAG
AAAAGTAGTA
AAAAATAGAA
GCCTAAAGAA
AAGGGATAT
ATTTCATCAG
CAACCTGCTA
TTI'TCTCTCA
GAAGATIT
TTAAAAAGAG
CTAGCTGGCC
AAACCTATAG
CCCAACCACA
GAGGAGAAA
GAGAAAAAAC
GTTGCGCCAC
GATGAATTGT
GAA
AGTTAGGGAA
TTCTGTCTGT
TTCCTTCAAA
GCCATTCACA
CTCAAAAACC
AAAAGCCAAA
AACATAAGGC
AAGAAGAGAA
CTGTCAAAAA
CCAGACAGGA
ATGGCGAAGA
AAATTTTGAC
ATI'GIACAC
ACCCAAGCTC
AGATCCCAGT
CCCCACACCC
GCCTGAGCCT
GCTCAAAAAA
AAAAGTAGTA
AGAATTTGAC
AAACAATAAA
ATTTGGAGAT
120 180 240 300 360 420 480 540 600 660 693 INFORMATION FOR SEQ ID NO:1396: Wi SEQUENCE CHARACTERISTICS: LENGTH: 618 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO P CT/K 'G /09 12P 1PENUS 18 DEC 1996 982 (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAmE/KEY: miscjfeature LOCATION .618 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1396 AGTCGTTATC ACCCAAGAGG GCTACAGGCA
CGGATAATGT
AACGTGAGCG CTrATTCTAC TTGTTGGGGA
GGATCAATGA
GATATTTT1TA CGCACATTAG GTTATTGGTI' TAGGCAATAT AAGGTGGTGT
ATTTCCCC
GAATI'GCTI'A
AAACAAGCGG
GATTTAATCG CTCTGAAAGA GGGCGTGGGG GCATTIGTGAA TATTACGCGA GCGATGTG
TTTTAGCCAA
GGATATAAAA
CGAATCTGTA
,TACGATCGT
cGATATTAAA,
CGGTAAAAGA
TAAAGATAAA
TATTATCAGC
ATTGCAA.AGC
TGAAAAGGAT
?I'GCCTAAAC
AGCGCGAAAG
GCCCAGCACA
TAI'GCAAAA
ATGGGGCTrA
GTCGCCAAGC
AAAGAAGAAT
AI'CATGCCC
TTAAAAGATG
T'rGGCT'rTAA
TCAAACTCAT
CTTTAGGCAT
CTTAGCGTG
GCGGGGAATA.
TTAAAGGAGG
TCGCTCAAGC
ACGAGCGCT
CCTTAAATGA
GGGcGATI'TT
TTTTAGAAAC
TrGCATCACC
AGAAGTCAAA
CGCGTTGTCT
TAGTCAAAGC
TCAATGGGGG
TTTrCGGGGCA
GAGTTTAGAG,
AAGCACGcGC
AATCAATGTG
CAAAGATTG
120 180 240 300 360 420 480 540 600 618 INFORMATION FOR SEQ ID NO:1397: SEQUENCE CHARACTERISTICS: LENGTH: 318 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .318 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1397 ATATI!AGAGA ATTTGAGGAT TrACGCCAGG TTGTTATTTT TAGCAAAGAG AAAACTTATT GGGAGCAAGC TTAATGAAGT
CGCAAGATCC
TT1TCCTAATI' ACGAATTTAT TTGGATAACT AAGCTCCAAG AAGCTTACAA ATCTGTAGAA ATATCAAAGG TGCAAAAA CTrTTGGAAA.
TTCATAGAAG
TATCAAGACT
GATGGCATAG
ATCTATAACT
TGATACTAAA
CTAA?1"ITA.
TAGCTrAAA
GI'GGCTAGA
TAAGCTATGT
AAATTTGATT
TAccATTAGT AKj'TTAAGCA
CGCTAAAAGC
GAATGATITT
INFORMATION FOR SEQ ID NO:139 8 SEQUENCE CHARACTERISTICS: LENGTH: 357 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) PCT/U %/091 2 2 IPENIS 1.8 DEC 1996 983 (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE: NO (vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .357 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:l39 8
TGCGTGATGC
TCTATGAGTT
GATTTAAATG
CGTAGCAGAA
TTTAAAGAAC
ACTAAAAAAT
TAATGGCAAT
TATTCGCCAA
Arrrl'GTTTT
AGGCTATGGA
AAGTAGATAT
TTGATr TGT
ITTTACCCCT
TATGGGGTTG
TGGTATAGAA
AAATCATCTI'
TAGAGAATT
TA'TI TAGC TATATTCTTA TTI'TGAAAAT GAGCAAATIT
'TTGCAACAG
GTGGGGCT ATAGCAATGC ATCGGTCTI' TrGTCCAAGC GAGGATTTAC GCCAGGCTI' AAAGAGAAAA
CTTATITCA
GATGAAAAAG
AGACATTAAA
GAGAAAAAAT
rCAATTAAAT
TGGAAATGAT
TAGAAGC
INFORMATION FOR SEQ ID NO:1399: SEQUENCE
CHARACTERISTICS:
LENGTH: 912 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc_feature LOCATION .912 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1399 CTI!GTGATcAAT GCTAGT1TTGAAG GACACGCTT A GGGGTGAGCA TCA ACTI'TAGAGC
AAA
CAAGCCATTA
TAG
CTAGACGAAG AC~ GGCGATATTC GTG
GATAATGGGGTA
AGTTTGGATG
AAC
?ITTTTATG G(.
'rrrl'TAAAT TC3 ATI'TATGAAG AT9
CAAGAGCTTTA
CAAATCTCTA AA( GCTAAAAAGA AT
CTAAAAC
ATTTGGG
TGTCTAA
CGCGCCC
CCACAGA
AAGCCT
,CGCGCTA.
CCATTAG
,AAAGCTT
CGGACTGCTC
TTTGAGCGCT
GAATTTGCAA
CACTAATGAG
GCCTAATAAG
TAAAGAATTT
TGACGCTGAC
ATCCTCTCTT
6ATGAAATAC
ACCATTAAGG
GGCATGGTGC
AAAGCGAGCG
GTCAATGATG
CCTGCCATTA
GTCAAAGCCT
AcTAAAATCG
AATAATGTGT
GGGCTTAGTT
TTrAAATTCTA
GGGOCAGAG
CTCATAGATG
AAAAGCCTGA
ATGGCGGAGC
TCCGTGCAAA
GCGAGGACGC
AATCTTATGA
ATTCGCAATT
TGATCAGCGG
TCAGCGTGAG
ATAATGAGCT
CCGGGATTT
'rrrCTATAG
TAGACGATAA
ACCCTAAAGC
AAATCCACCA
GAGGGAACGC
.CCAAAGACAA
!GCTTTGCCGC
TITAGGCAAG
AGCTTCGCAA
cACTTACAAT
GGTTAATATC
CAGAGACAAT
TATCCCTAAA
TAACGGCGTG
CGTGCATACG
GGGCGTGATG
GACTCAALGAT
*AGAGGGCATT
TAAATTAAAG
AGAAAACGCT
TTATGATAGT
120 180 240 300 360 420 480 540 600 660 720 780 840 900 912 ;CTAAATr ATCAAGTGCA GCGATAG CAAGGATATG ATCAAGT CATCGCTAAC ~CCCTAGA CAGAGACGCT %AAACCCG CTATAACATC CCAATCA AAAATTCAAT TGATGATCGA
TCAAGCAGCG
INFORMATION FOR SEQ ID NO:1400: SEQUENCE CHARACTERISTICS: POCTK12Oi! 09 i2 IPENUS 1L8 DEC 1996 984 LENGTH: 387 base pairs (B)TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .387 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1400
AGGAACATI'A
GAATCCCCGG
GCCAAACGCT
ACGGATATIT
GTGTATCTTA
AATGACGCGA
AGGGAAATCC
TGCAATACC
CAAAACTCAT
GTATTGAGAA
TCACGGAGI'
CAGGCI'ATA-
GTAAGATTGA
ATCAGATGA
TAACGCTI'AT
TGAAATGCTTI
TGAAGACAT
GTrGAATATl'
CACCCATCAA
TTTGGTGTTG
ACTCGCC
CAAGCCTACC
TATGAAGGGA
GAAAAGAAGA
T1'AGACTATG
ATCAAAGI'T
AATGTGGCTA
AGCATAACCG
TTTAAGATT
TCTArrrATAT
AAAAAGGGGG
TAACGCAAGC
GGGGGTTGTr
AGTGAGTGTG
TrCTTCGCAA TAATAGGGTr
GAAAGTGGCG
CAATGTGGAA
AGAGGCATGG
120 180 240 300 360 387 INFORMATION FOR SEQ ID NO:1401: SEQUENCE
CHARACTERISTICS:
LENGTH: 249 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .249 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1401 7TTGATGATC T'rrATGGATC AAACTCACT CCAT1TTATC TTICCCCACTT TCAAATGGGC GTTACTCAAA
GCGTTGATTA
GGCTGGCCCA CAAGGGCGAC AATGATTCT TTCAT GGGT GTTmTTAA T1TTTGGTTA TATAGTTI
AAAAGTTGGC
ATTGTTATA
INFORMATION FOR SEQ ID NO:14 0 2 SEQUENCE CHARACTERISTICS: LENGTH: 660 base pairs TYPE: nucleic acid STRANDEDNESS: double
CACGGGTAAC
AGGACGAT
TTGAATGCTC
ACTATAGCGC
CCCGGTAAAA
CCCCACATTA
cGcATTAAAA
TATAAGACTA
120 180 240 249 ;tI DE D Si E POUS 96/09122 I PEAIUS 18 0E C 1996 985 TOPOLOGY: circular (ii) MO LECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .660 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1402
AAGCGAGACA
GAAACCATTC
CTAAAAATCT
CCCCTTTATI
'L TATCAAAG
AAAGAGCTT'
TI'TAATGGCA
ACCTI'AGACG
GAGCAGT'TC
AATCTAAATG
TTAGTGCATG
AGAATGTI'AA
CTAATATAAG
GTGAATGGAG
TGCATGAAAT
TAGGGAATTT
TAGAGGACT'
GAGGTITTTGA
C1?I'rTACAG A TrGGATT
GCGTGCTC
CGATTTATTA
AATGCGAAAG
C'ITGTGTAAA
TTTTGAAAAG
CATCTCTT
TGGTCAAAAA
TTTCAAATAC
TATI'CCCCTA
CCAAGAAAAC
GATGGATAGC
TATGACGAAT
CAACCCCCAT
GGGCGTGTGA
GAGCATTC
CAAAAAGAAA
GCAGCAGTCA
CACGAGAATA
TTTAACGAAA
CTCACGCTCA
AAATGGGAAA
TTGAGCCA!Fr
ATTICCTGGTA
TI'AAGGCCAA
TG'TATGCGT
AATI'AAAAGA
AAAGCGGGAG
'ITGGCGATGA
AAGAGGATTT
AGCAACCGCG
AAGCCCTI'AA
ATTACCGCGC
ATGGATCCGT
AATTTGATGT
AAGGAGGAAA
G'rrrGATATA
AGACGATGCG
CGAGTTI'G
'ITACGGGCAA
TGCGAGCGAA
CCTAATAAGC
ATACAATT1'A
GCG'ITATAGC
TAGGGGGTITG
GAGCGGGGAC
AAGGCATI'AT
120 180 240 300 360 420 480 540 600 660 INFORMATION FOR SEQ ID NO:1403: SEQUENCE CHARACTERISTICS: LENGTH: 762 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc_feature LOCATION .762 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1403
AGATTI'AAGG
TGCCCCTTAA
AGTGATCCTA
TTAGCCCCAT
7In~IrAAGGA
TCTTI'GATAT
ATTAAGCCTI
CCTT1'CAAGG
ATTAGGAAT
GCATTTATGA
77 rTrGGTGA
CCGCCTGTAA
CTAGAATI'GT
TGAGCGCGGA
AACAACTCGT
CGTI'GATT
CCGCTI'AGG
TGACTI~Tr
ATATGGATAA
AATrCATGCT
TGCCTAACCC
TAAGCGAGTT
TI'GATATGGT
TGATTTCTCT
GCGTTITC AT1TlWITIAA TAGCGCTrA
AACCACCCTI'
AGTGATGACG
CACGCAACAA
TATCATGGAA
AAAGATTTCT
TAAAAACACA
TAAAACCCCT
GAAAACAGCG
TATCAGCTCT
GCCTTTTAAA
CCTAGCGTCA
AATGTCATCG
AGTTTCACCC
ACCCCACCCA
CCTAGCTTGA
TACACCGAAG
CGAGAAAAAG
GATGATGTGA
TTTCAAATCG
ATTAATGG
ArII'GGTGT
TTCTCATTTG
ATCTCTCTTT
CCTTACTCAC
GTTTGATCGT
CTCAAATI'CT
AAAAGGCTTA
CGITTGAAAA
ATCTAGCCCT
GCTTGAGCGT
GC TTTACT
CGATGGGTAT
TTATTCTGGT
CCCT'ITAATA
AAACGCTCCT
GCTTGGTT
GGTGTTCT
AGTCTCGCTC
TGATACAGGG
AAGCACTCTG
TTTTTTAGG
TTTAATCCCG
CTACTTGCCT
GATGATGCTC
GGATGGGTTT
120 180 240 300 360 420 480 540 600 660 720 IPANS 18 DEC 1996 AAT=AmrGA CCGAAAA~rr AGTGGCGAGT T TAAAATGG
T
INFORMATION FOR SEQ ID NO:1404: SEQUENCE
CHARACTERISTICS:
LENGTH: 1842 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomiC) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .1842 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1404
AAGTGGGCAA
GATCATCAA
GAAGAAAAGG
GTGGATTCCA
AAAAAAATGC
AATACAGAAA
AAAGAAGATC
AACACTACAA
TACAGCCAGA
AGTTTTGAAC
ATTTTTI'TAG
CAAAAAGCCC
AATGAAGA'rr
TCATTCTTGC
TATATGAGTA
AAGAGTTTTA
AGAACCTI'AC
TGCTCGGCAA
GCTGGGTTTG-
AAATTACTCA
AAATACCGCT
TACCTCAAA
CAATACCCTA
AAAAACGCTA
TTGGATAAAA
GTC'TTAACC
GCTAAAGAGG
AAATCTGATC-
TTI'ATCGTG1 GAAGCTGG GC GCGTTTTCC1 'T1'TACCGGG
TCACTATCAT
TGACTAAAGA
ccAATTTAGA
TGCTTGCGCT
AGCTCTCTCA
GCTTGAACAC
ACAACGAAAA
GCGCCCAAAG
ACACTITATAA
GGTTTATGTT
TTGAAGAAGG
TAGCGTCTTT
cTTTAATTGT GGGTAGCGrr TCCCT1'TAAT
AAAACTATAA
GACTGCCTAT
TGCTGTTTTG
AATTAAGCGT
TTCCCAGTTG
AAGCCGGGAC
AAAATGATGC
ATCTTTCAAG
*AGAATTITAAA
*cTATGGATTT
TGGTGGTTTC
CTTTTAGAGA
TTGTGATGTI
GGATCAAGT7 TGATAGCTT7
GTTACCCGTG
TGATTrACCG
TTTTTAGAA
GcGTAATTTA
CAACATGTGG
AGAAI'GGGG
AGAGCTTTA
CATCAAAGTC
AATCGCTAAA
GAT1'GATAAG TATCATCTerr
GTITAAAATT
GGTGGGCGAT
GGTGTTGTAT
TI'TACTAGAC
CACCGGTTTT
CGAACGATTG
TTATGTGCTG
CATTTATATr
GTTTAAAGGA
GAGAATGGTC
TI'ATATITI'A
GGCTATGAAG
CGAAGCTAAA
AAATAGCGT7' TGATTw1GGCG1 tACTIGGG
GATAATCAG)
TTATATCCCI]
TG;TAGCGTA1
TATGCGACJ
GATAAAATGG
GGCACTTACG
AAAGGGCAAT
GCCTTAAGCG
GATGAAGCCA
GI'GTGTGCG
TTAGACGAAA
CCATCTCAAA
TCAGTGATCA
A'r1TrAATGC
TCTTTGAGCT
TTGAGCGATA
GGCATTATTG
TTTGGGATIT
GGGATCTTGC
GGTTGCTCAG
ATCACGCT1T
TTTGTAGGCT
TTGGGGGCGG
CAGACTGAA'I
TAT1TCAGTA
GTGGGAGCGA
AC~rrATAAAC *GAAGAAAAA1
GTAGGAAGAC
TTGAGCGTC1
GTGTTGT=T
LAAAGAAGTCJ
?TGT'rrrGCA(
TTATTCATC'
~CAAATTTTQ
AAGTGAG TT
CGCTCAATGA
ACAATCTCAT
CGcAGTrATT
AGAAAGAAGG
TGCCAACAAG
TTGTCAGGCT
GTITTAAAGA
GTGAAAACAA
ACCAGCGTI!A
TTI1TAATAGG
GTATTAAAGA
GGGGAGTGGG
CTT1TACTAGA
ATAAATTTGG
TGCCTGcTTA
TTGTGATCGG
cGTTTTTCCC
TTGTGGCGTT
CCTTITATCAT
TTACACCAA
T1'TTGATCTG
AAGAAAGCTT
TAAAAGAAT7
GCGGGGCGTA
SCGCTTGTAAC
r' C?1'TAGGGG) k GCGTGCCTAC CGACCAT'rAC r TcAcAACCGI 72 TT
GATCCATAAA
CTrCACCACT
TCTCAATGTG
AGACACAAAT
GATCAACATC
CGCGAGATCC
TTATITCTCAA
GTC'rrTAAAA
ACAAAATGCG
TGGGA'TTrC
AGGGGGAGTG
AAATGTGGCT
AQCGACGGTT
GACGACAGGC
TT1'GCATGGG cATGGCGACA
CTTTATGAGT
cTCTI'CAAGT
AGTGATGGCC
GGAAXTGCCC
ATCGC'TTCT
GTTTATGTCC
1GTTAGTCCAA
*AAAA.ACCGAA
TTrAGAAAAA
CGGTTTTATG
LTCAAAACGAA
CGGGATCGCT
'T711-GGTAGG r' TGTAGCGTAT 120 180 240', 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1140 1200 1260 1320 1380 1440 1500 1560 1620 1680 1740 1800 1842 INFORMATION FOR SEQ ID NO:140 5 SEQUENCE CHARACTERISTICS: LENGTH: 975 base pairs TYPE: nucleic acid STRANDEDNESS: double ,VP a TIDV PCTUS 9 6/ 0 91a IPEANS 18 DEC 1996 997 TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .975 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:l405
ATGAAAAGAA
CATAATTTGG
TGGAGGAGCA
CTCACTAAAA
ATI'AGAAACT
GGAGGCCCAG
GCGCCCTATG
ATCAGCGTAA
ATCAACATCA
ACTIITTGGG
AAAAGCTTAG
AAGCATTITG
AGCCCTACGG
AAAATCACCG
ATAGCCGCTT
AGAGCGAAGC
ITTTTAGTC
AAAGGGTGGA
AGGAAGTTAG
GCGCCAATCA
CTACCGGTAT
GGCATTCTAA
TTGAAATTGG
CTAAGGGTGG
TCACCAAAGG
GCAAGTCTGA
TTAATAACAT
GAATCCAAGC
ATATI'CAAAA
CTT'TTrTCA
ACAATCAAAA
GATGGGGAGC
TTTGGCTGTr
AGCTTCAGGG
AAATI'ATATG
AAGCAFI'GAA
TGGAGCTGTG
TACGGGAATG
CACGGTTATT
GGAGAGCGTG
CATI'CCTACC
AAACGGGGGC
GCTITTTAAC
TCAAGTCAAT
'ITACATGTTA
ATATI'ATAGT
TCGTTI'CAA
TGTGTATCAA
TI'GAGTCATA
GTGGCTAACG
GGTTCTCGCA
GAAGCTTTGC
CCTAGCA'Tr
ATTCTAGTCA
TTTICCTGTAA
CGTTATGGCC
AATTGGGAAA
Tl'TTTCAATC
ACCTATITAA
TGGCTCAAAG
GATTCAI'GT
TATITCTI'GA
AACAACCGCC
AACTr1'rrrG
GCGCGCATGC
ATAAAGAAGC
CGGTGATrC
AAAATGTGCC
CCATTAGGGG
ATGGGATI'CC
CCTITCAGTC
CTAACGCIWIT
GTCAGGTGAG
AAAATTCTAA
GAACGGGGGG
GGCAAGGGTT
ATCAAATCAA
CAGACCCTGG
CCAATAACGA
GGGACACGGA
TGTCAAAACT
GCCTTTAAGC
TAACAAGCAA
AGGCGTGCAT
G'ITTGGTGCT
TATTTATGTC
TGTGGATAGA
TGGCGGTGTG
CGAGAGGACC
AAACATI'GAT
TATGATGAAT
TAGATACAAC
TGATAGCAAT
ATCTTTAGGC
TAAAAGCGGG
TAGGGTAGGG
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 975 GGGGGATI'TC ACTT INFORMATION FOR SEQ ID NO:1406: SEQUENCE CHARACTERISTICS: LENGTH: 2391 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .2391 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1406
AGACTAAAAC
CAAAAAGTT
AACAACATIT
GGCATCCTCC
CI'TrCACTG
GTTAAAAGGC
CAAATGTTAT
CAAACTATT
TAGGCTTGTA
GTTTAGAGGG
AGCGCCAAAT
GTAAAA ETGA
AGAGCGTAGG
'rrTAGGGGTT
TGATGAGCAT
GG'ITAGCTAC
GGCGT'IAGAT
TTATAAACAA
ATGTTAGAAA
TTGCCTAAAA
TTITTGCTCA
ACCCATT'rAA
TCTTTAGAAA
AGCA'ITCAAT
AGCTTTTAAG
GCTAI'CTAT
cTAAA4ACGA
GCACAGACCA
AAGTCGTGGC
CTGACTCTCA
CGCTATCAAA
GAGCGAAGAA
AAACTTAGTG
ATTGCAAGAT
GcGTCTTGTG
ATACTI'GCAA
120 180 240 300 360 POT/US 96/0912? I PEMJS 1.8 D EC 1996 GCGATCTINA ATCAGTrGA GAAAGCACTC ACTCTITTGCA AATAGAGAAA A'rITrAAGGA AAAAGCTTAG AAATCCAGCT TTGAATTIVIT ATGCAGAATA GGGTATGA GCGATAGCTA CAAGAAAGCT TrAATCAAAA GAAAGGATCA CTrCTATAGC ATCTITTCCA TAGAGCCTAT AAGTTTAGCA TGTCTAATCT ACcAAAcGAT TATCCATGCA GAGGAI'TAG ACGCTCAAAC GGcGTTATAG AAACT GG CATITAAACC ACCGCTIGCG GAAAGGCAAA ATTTIAGGTT AAAAATrTGG ATTATTCCCC AACGCTAAAG AAATTGCCAG GGTAAAAGCA CGCTGATIAG CT'FI'AGCTT TrGACAGGAT TACCATGACG GCCAATCTT ?TAGAAITI TGCAATCCTI' GAAGCCTI'AG AAGACATGAA TACCCCAAAG ATTrTAGTrI' CAATrGGGCT TGAG'rrTAGA GCGTI'CAACT CCAACGCTT AAAGAC'ITAG GGCTITTAGC AACGACAGCG GCTTrTTGGT TTAAACACTA AAATCAACGC TTGGCCTI'GC AAGACATTTA AACATGGGGA CTCTCAIT AATGTGCCTI' TGAGCGAAAC CAGGTTTIAG TCAAAAATCT GGCTTGGGGT GT1ATTTGAA GCG'ITACAAA AAGACTACCC
AATA.AAGAA
TGGCGITTFIG
TATTCTCTCT
CAAAAACTAT
TATTAATGGG
TATCGCTAGT
AACCTATAAC
GGTGGGAGCG
GAGCGTCAAT
TGTTAAAAAC
AAAATTCGCC
CAGCTTAATI'
CTTGAAAGGG
TTT TrAAcC
TAAGGCTAAT
TTTTTATTC
AGTGAATGGG
CTA'TTAATG
CCAAGGG?1'G
TAGTATCAAC
TTTrGAGC
TGCGATTCT
GCTGGA TT
GCCGTATTI'G
TTTAAATGTG
CTATTACTI'G
TTITrTTAGAC rFITAATCACG
CCAACTTAGC
GTATCCGCAA
TGAAATTTCT
GGGTAACGGG
AATCTTTAAT
TACAGAGTGG
GTGTATGAGA
GAGCATAAGA
TATAAAGCGC
GCCCCCAAAC
TTTGAACTCC
TCTATCACT
CGC ITGATI'G
CTTTATACC
AAAACGCTGA
GAGCTATI'AG
CTAAACGTTC
TrAGGGCTI' GGGTATI'I T
TCTAAAGCCC
ATCAGTATTTI
AAAAATCT
ATI'T TGCA TCT1'AAACTC CTTAAAAcC
TTGAAAAAGA
GCATTIAAAGC
AAGAGACGCC
GTITT1'AAA
AATACCAAGA
TI'ATCAAAGC
TATTTAAAGA
CCTTrrCCC
TAGCGTIGT
TCATG.GGGGA ATAGCCCmT AA'TrTCCACA ACCAAGAAGT
CATACTITAG
ATGAGCGCT1 TATrCITrCA CCCTrrGTTl
ATGTTGGATC
GGCGCGATTIA
AAAGAAACGC
AATAACCCCC
ATAAACCTAG
TTTTATAAGA
GAATAAAT
CAAGCCAGGA
GGGGITAAAA
AAAAACGCTA
TTTAGAAA
AGTTCCAACA
TCAGATT1CCA
CGTGAGAAAC
TTATAGGGGC
TAAAATACCA
CCGAATITTTT
TAGAGCCTAA
TTGCCCCTTC
AGAGCCTTTA
TTAAAAGAAC
'rrITrAACGC
ATGCGATCAC
TCTTAGAAGA
CCTATGTGGA
AAGCTAATGG
ACGCCCATAG
GGGAATrGAA
ACACCCCTCT
TGATTGATGT
GTCATGTCAA
TTTTGAAGAG
TTTAGTTTTA
CATGCACGCT
AGAAACTTTA
TAAAGAGGI'
CCTAGTAGGG
TATTTCATT
TTATGAGAGC
'rrTGGATA'rr
AGAGAGGGCC
ATI'AGTCAAA
CCCCAGTTG
AAACTTAGTG
TGAACGCATC
GATGGTGTT
GAGCGTGTT
GAGCCATAAT
AACCGGAAGC
AAACATG3CGC
TAAAGGGCAT
ITTGCAGAAT
AAGGGATAAA
TGAGACCTTA
CTCATCTAAC
TTI'GAATGAC
CCAAAACCCT
GTCTAGGAAA
AAACGATTTG
CGTGGTGGTG
TTTTTAAGC
ACACAATTTC
GTATGCCAGG
GAGTTTGGAG
TAAAGTGAAA
T
420 480 540 600 660 720 780 840 900 960 1020 1080 1140 1200 1260 1320 1380 1440 1500 1560 1620 1680 1740 1800 1860 1920 1980 2040 2100, 2160 2220 2280 2340 2391 INFORMATION FOR SEQ ID NO:1407: SEQUENCE CHARACTERISTICS: LENGTH: 1587 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .1587 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1407 AAAATGAT1'C ATTAGCTC T
CATGAAGAAA
GGGTGTGGGG
GTGGAAGCGC
Grr'rATTACG
TTAAAAG'ITC
ATGTGGATTI'
GGAGCGCGAG
CGAGCGGGGA
TTGAGAAAT
ATCATAAAGA
CATGATCGC
GAGGAAATCA
TTITAGCGTC
TAGCATTAAA
AGCCCACCGA
AGATTACCAC
CTTTTACAAA
GGTTCGAATT
AATCAAGTTA
TTTGTGATGG
TT1CAATATAG C'TTTrAGAAA
CGATAGATAT
ACATGGCTTG
AAGGGTTTI'A
CGTGAAAA
CTTTAGAGTA
TGGTGAGTI'C
TGTAGAAGTC
TCCCcTTT cTAT IGC'TT AC'TrCGFI'T
TGACAAAGGC
GTTGTATCAA
120 180 240 300 360 AM N0E D 8E
PC
T 96/0912Z.2.
HAMNIS 18DEC1996
GAAGAGCTT
GAGAGCATCA
AATAAAGGCT
GAGGATAAAA
GCTCAAGTGG
TCGCCCCAAA
GAACACATTr 'rrGCACCAGG
CATTTGCCCT
GCAGGGCGGA
GGGGTGATTT1
GAAACITTAA
ATGGcGGGTT 'FrAGGGTTT
ACGCTITTGC
1?ITACCCCA
CCCAGTTGG
TTGGAT'IAG
GACGc'TI'AT
AATTTACCCC
Ti'GAGCCGC T1'TAACGCCCC
AAGCGTTTAA
TGAATAAGGA
CCTATTI'GCG
TGGGTTTTGG
ATAAGCTT!
ATAAACAAAA
CGGGTTTTAA
TGcTTAAAAA
ATGCGGCTTA
TGTTTGAAAA
AA)A Z GGCT CTTATC71r TGAAAAACTr
AAGCGCCTT
AAACAGAAAA
AATTrAGA
CGGTGGGTI'A
GTCAAGAAAA
TAAAAAAAGG
CAACTCAAAG
GTTTITG
GTTAGGCTTA
CAAATTGATT
CTTTTTlGGAT
AGGGCGCACC
TGATAAATCC
GCAGGTCAI'
AAACGCCATA
AGGCGATCCA
TAAAGCGAGC
CAACCTAGAC
ATCGCGCCCC
AGACGATCCT
TTCCTTGCTT
GCATGTTA
GccTAATCGC
AAAATTGGTG
TATCCATAGT
AT1'GGACGAC
GGGTTGAA.
AAATCCC
AATTATITTGC
TGCACGAATA
GAATTGGGCG
CGcATCATGT
TTAAAAGAAA
AGCTI'GCTCT
GTAACAGAAG
GCCACGCTTG
GAAATCCTTTI
TTGATGTTAG
CCAGCGGATA
ATAGCTTTCA.
r1AGAAAAAG
TTACAAAATG
GGGATTAGAG
CCTCAAAAGT
ATCCGCTACC
GGGGTA?1'CT
CCTAAATTAG
AAGGAATTGC
AAAAAAGAGG
AAATTrGATrA
TGCTAGGCAA
TCCCTATI'A
AAGCGGCCAA
ATGGCTATCA
GGTATFIGGA
GGACAGCTTI
TGAGCTATGA
CTAAAGAGCA
TGATCGCTAA
'rGATIGT
ATAAGGCCCT
AATACAAGCC
AGCCAGTTTC
TCGCGCATGT
TTTTAGAAGA
TGcATAAAAA TI'GCGI'ATT1 GTrTTGTGAT
GCTTAGCATG
cGGCATTGAA
GAGCGATAAA
TAGCCCTAGT
GTATATCAAT
TTTGGCTAAA
TGTGATTTTA
AACGCCATCG
TGGGGATAAG
AAGGAAAGGG
TCATCAGAT
'FrrAAGGCAC
TAAAGAAATG
C'rTAATCGCT TTrrrCAGCCT
'ITCTAGCATG
CAGAAGCCTA
ACAAGAM'I
ATI'AGATGCG
TTrTGCGCTAC 420 480 540 600 660 720 780 840 900 960 1020 1080 1140 1200 1260 1320 1380 1440 1500 1560 1587 INFORMATION FOR SEQ ID NO:1408: SEQUENCE CHARACTERISTICS: LENGTH: 1290 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .1290 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1408
CTAAGAGGGC
ATTGAAGCTA
AGCGTrAGGG GCC?1rAGGG
ACCGCTAATA
GTGTCCAGCT
GAATTAGAAA
CTCATrATI'G
ACGA'ITATGC
ACCAAAAAAA
GAGAGTAAAG
ATGGTGTIG
GCATGGACTC
GGGGAATTGA
TTTTCTGTTG
GAGACCGATG
TTGCACTTGC
ATGGCGAGCG
ACGGGCGAAT
ACAGGCGTAC'
AAAAGATGAA
GCGATCCAGC
ATCATTACGC
ATATTGACAG
ACACGCCTAG
AGCACGCCT'
AAAAATACAC
GTAA.AGCGGC
GCGAAGACAA
ATITTGCGT
AAATTGACCC
CAGTGGGCGG
AACTCACCGG
TCAAAGTCTT
CAGAGAATAA
ATGTCCCTGA.
TGATGGCGAG
TGACTTTGAG
TTATATAGGC TCCATGCCCG
TCCGGTCATG
GAGTGCTTTA
GAATTTCAGC
GATCCCAGCT
CGAAAAAGAA
AAAGCCTAGC
CAGAGAAGCG
t
TTAAAATAC
AGATAAAAAA
CTCTATCACG
CATAGATGAA
TGATGTGCTT
GAGTTTGGGC
GTTGGATAAC
GAAAAAGAAA
GGGGGCTACG
CATTTTGTGC
CGGGGAAGTI
GTTTTAGATG
TTAGAGATCT
ATTGAT1'TGT CCmTAAGAG
GAGATCGCTA
GAAGTGGATA
GGCGTI'IAGGG
CTAGAAGATA
GGCGGA.AATG
CCTGATAACC
GAAAATAAAA
AAAATI'GAAG
GACGTGATGA
GAAACCTTAA
AAAGTGCTGA
CCTAAAGACG
GATAGGGCTP
TTACCCATAC
GGCGTATTGT
AAATTGATAA
TAGACCCTGA
CGCAAGTGAT
ACAGAATGGA
AAAACTACCT
TTAGCCATGA
ATTTACGAAG
ACCCGCACAA
AAGAAAACGA
rAAAGAGTA
TCGGTATCGT
CGGITAAGAT
AAGAATCCGC
,AAGTGCCTAA.
,AAGTTTATAA
GCCCGAGCGC
TAAGAAGCGA
GGGGGTTGAA
CCAAGGGCTT
GGTGGATCGA
GCAAAATATC
TTTITATCGCT
XITrrATCAGC cATCCCCCAA
ATGTTTGAAA
ACAGATCGCA
AAAAGGGCGG
AAAAAGAGGT
TrrAGAACGC
CAATGGCT'G
TAGAGGCAAG
CATTAT1'GCC
AATCCCTAGC
CGCTTACGAT
TGGGATCGCT
AGTGGCGATG
AGAAAAATG
120 180 240 300 360 420 480 54 0 600 660 720 780 840 900 960 1020 1080 1140 A.q.4PJr',;ns4;z-r I PEN1S L8D0E C 1996 ATCGCTGCTT TTAAAGCCGG CATCAAAACC GCTCTCAITC CTGTCAAAAA GAITI'AGACG AGATCCCTAC TGAAGTGCGA GAGAATITAA ACATCGTTGC ATcGCTGAAG TGT1'AGAAAA AACCTTGCIT INFORMATION FOR SEQ ID NO:1409: SEQUENCE CHARACTERISTICS: LENGTH: 816 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 816 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1409
TTACGAAAGG
GGTGAAAAAC
1200 1260 1290
AAAAGATATA
AGGGAAT
CGCTI'CAAA
TTTI'ATACGA
CAT1ACTTGC CTCA 1TGGCG
ACGCTTGAAG
ATCGCGTCAA
ATCTT1TAT
GTGTITTTTG
GTITTTAAGAT
AAGGTGTI'TA
CATGTGCTGA
AGCCTGTATG,
GAAAAACTGC
TrIAAAAGCGT ACGCCT72TIr
T'ITTGTCI'T
AAGCGCACAG
CGATTAAGGA
AGGTGTCTAT
AAATTITTGA
TTTGGGGGTT
ATATTAAGAT
GGATAGGCAC
AACAT!ATIT
AATGGGCTTC
GGAGCCGTT
TCTCTTACGG
TAGAGGGT'T
AGGGTTAAGC
ATCGCCTATT
CGGTGAAATG
7TTI'TAGAA.
TGTGGTGGCG
CGCAAAGCCC
TGGCACGACT
CCAAGTGTTT
TTACGCGTT
TTGGGTGTTr
CACCTATI'I
CCCATTTTGT
CTTGACAATG
TTGAACCTrrC GAATl'GTT
TTGTTGTITCG
GAAGCCTTGA
AAT'TrAAAA
TI'GGTGCTT
AGAGATI'ATG
'rAGTGT
TI'TGAAGATA
T
TTTIGATCC
TTATGGGTGT
ATGTGTI'ATA
GGTTTT
GCGACAAGCT
TTAGAATGAT
ACTACGCTTC
TGTI'CAGTCT
TITI'CCCTAA
AAACAGACAT
TTrGTGAAAA CGCA1TIAA
TATTCGCTT
AAGATTCAAG
'TTTTACCAT
TTITI'ACGAG
CCAATCCGCA
GTCAT1'AAT
TTTCCCCGAG
CAGC'rrGAGT
TTTTGTGTCT
CGCTCCTAAA
GACCTTAGGC
CTACCGCTCC
GGGTAAAGAA
GCCTITTGGTG
CTTGTTGCAT
TCCCACGAAT
CG TrCTTGG
CTTACTCATG
120 180 240 300 360 420 480 540 600 660 720 780 816 INFORMATION FOR SEQ ID NO:1410: Ci) SEQUENCE CHARACTERISTICS: CA) LENGTH: 747 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .747 Pc1/uJ) 9 6/ 09 12a2 I PEMJS I b 0EC 1996 991 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:141O
GTAGGTGTTG,
AGTGTGTI'AA
CAAAGTGCTG
GAcAATAACC
ACCGTTTTGA
CCAGAAACTT
GAC 'ITTAG
CAAAAAAATA
GAAGAATCCG
GCTAAGGAT
TTGcTAAAG
AAATTCGGCA
CCTATAAAAG
TTATGATAAA
ATGCCAAAGA
AGATCAGAGC
TTAAGCTCGT
ACACTTTTGA
GGGATAAAT'
AATACGCTAA
AGGCATTCAC
TTrGTTAAA
ATGCGATTGT
ACGCTAAAAA
CAGAATGGAT
CATGGCAAAA
AAAGACCCT'
ATGcGTCG CTTGCAA ITA
TAAAGACAAA
TTATGCGGGC
TGAAAAAGAA
TTCTAAGGGC
Tr'TAAAAACG
GGAAAAAGGC
TTTACAAGTG
cAGCCAAGAA
TA'FITTACCC
TAAAAAA
GCATCGGTTT
CCCATAACAA
cAAAGTTACA
AAGCCAGCCG
TATTTAGTCA
GGCTCTCTTA
GTTAAGATITT
CTCAAAAGCT
AAGCCTAAAG
GGCGACACTT
CAACAAGCCA
AACTCTCITTT
TAT1'AGGAT'I GAGITIGATG GAAGCGTTAA GTATCATCAG AAATGGCGAA AATGGCGCTA
TCATCTI'GGA
AAAACTGCAT
CGCTCA LTCC 'rrrACATTTC TTIAAGCTcC
CCGTTAGGCG
TGCATGATTI'
AAGTCTTGCA
ATGGCACATG
TAAATACACC
TGGAGCGCTA
TAACCGCACC
CCAAGTGAGT
GGAGTI'AGTC
TGACGCCAT'
AAACGCTCAA
GGAAGATGGG
120 180 240 300 360 420 480 540 600 660 720 747 INFORMATION FOR SEQ ID NO:1411: SEQUENCE CHARACTERISTICS: LENGTH: 1089 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .1089 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1411 CATGACAAAA AATITGATCT AAATGCAAAG
ACAAAGAAAA
GATI'TTAT1'T TAGTGA'ITCC GTAGAAGTGT ATI'rGGGCGT CCTTTCATTG ATGAAGTTAT TCCACCGAcG cccTTATCI' 'rrGAGAAAAT CCATCCCTA CAAAAGAGAG TGCGCCAAAA GACTTAATCC ATGCGT1T1'IG GCATGGAAGC TTAAAGACAA AATGTTGATC TAT1'GTGGAT CCCGCTI'CGC ATTTcATI'GA ATTCTTATrrr
GCGGGCCAGG
TTCGCTCACC TCTATGATAC TTAAGCGTCT GTATCGGGAA CAATCTATCG GGTITTACCC AACGAACAAT TTTTAGGCAT ATTCAAAAAG AAAGCGAAAA
CAAGAAAGA
CTTAGGCGGA
CTCTCAAA.AA
CGCTTTvAATC
GGTTGTGCCT
CATAGAAGAC
TITATTTTCT
TATCCTAGCC
CCGCTCTTTA
TAAAGACTAC
ATCCAAAGAG
TGGCGTGCAT
pTTGATTGCA
CGAGAGAAAA
GAGCCATAGT
CGCTITCAGGC
TAACGAACTC
CACCCCGCCT
GATTATGGGA
GTCATGGA'rr TCGTAGGGTT
GT
T
IVTGTGA~
GCTCTCAAGC
AGCTATACCA
AACCATFITAG
AATTITrAAAA
CCAAAGACCA
TGC~rrAAAAA
GATCTCCCTA
CGATCCATCA
ATGCATAGCG
ATCTTGCATG
GCCACAGAAG
'rrAGTGGATT
CCITTGCATG
ACCGCCTCTA
AATGGCTCAA
TTTATCACAA
ATGC'TrTrr7.C
CCCCAATCGC
CCACCACCCC
ACGCCAAACT
AAATCTATTC
CCGAATACGA
ACGCTCAACT
TCGCTTCAAA
GAGGCAGTTC
AAAAATrAAG
AACTCCTTAA
TAGCCAAATr
TGAACGCTT
?I'GCCAGATG
ACGATATGGG
AAAATCTITrC rGAAGATTTA TAAGTrAGGC
A.GAAAAAGGC
TTAGAATTC
CAAAAACCGC
TGCITTCAG
TTGGCTTTAT
ATACAATTTG
TAAAAAAATC
ACTCAACGCT
GCCCGTATTG
'rrGTGAGATC
AGAAGTCCCT
GTGCGCGAAT
ATTTGACAAC
GCGGCCITTC
ITTTGATTGAC
TCATCACATG
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1089 INFORMATION FOR SEQ ID NO:1412: SEQUENCE CHARACTERISTICS: LENGTH: 1986 base pairs AMENDED s E li" IPENS 180DEC1996 992 TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc..feature LOCATION .1986 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1412
GGTAACACGA
GACATCCCTC
TACACGCTTC
ATCGAACAAA
GCGATTITI'A
ACAGACAGCG
GATATTTATA
GTCTCTAAAG
ACGCT TI'AG GAGT'T EACG
TCTTTTATTG
A PrCCTFI'GC
TTATTGAAT
TTI'GAACGCG
CCAGCCTI'
TGGACGATAG
CTCGCCATGG
GGGCAAGATG
AACGATT1TGG
TCTCTAAAAA
AT1TTTAGATA rrTGTrrTAATA
CACAAAAACA
CTACAATCAA
GCTITCT
CAAGATATGG
ATTGAAAAGA
GCAGAAAAAA
GAVI'TCAAGA
TCCAATAAAM
TCAGGGATCG
GCTAATTTAA
CGAGATAATG
ATCAGC
TrrATAAAGAT
ATATTGGCCA
AAGGCGAAGA
GTGCGAGACT
AAAACCAGTG
AGCATCAAAA
AAGGCACTITA
TGGATAATAC
AAGAAGAGAG
CTAAAAACCC
AGCAGGGTF1'
CTAAAAAGAT
ATGCGAGCGC
CTAGGCATAT
TGATGAGTT
AGGGCGTGAA
AGTATGGGAT
GGGATT1TTC GGAATTTGTr
GCACCAAAAT
ACGCTAAT1TC
TTTATGATTT
ACGAATCAGA
GCTTCT'TGCT
TAGAAATCAC
TITTACAAGA
TTGAAAAGAT
AAGAAAAAGA
.AAGTAGAGAT
TACTGCGCTT
CTTrGGATI'A
AACCCGCAAA
ATAATCTGGC
GCAAAAATCA
TGCTTATACG
AGTCTTT1'1
GAGGAATCAA
GGATTTITC
ATGCGTGCAA
TAGCGGGTAT
AGATAGTAAA
TTATTTIC
TGAAGCGATT
ATTGGATCTG
GAACGATCCT
GTTAGGGTAT
TGTGGGTAAG
GAATTTGCCC
AATGAGTAAG
TGAAGAATTA
TAAAAAAGCG
GAATCGTFIG
CACTGCGTAT
TTTTGTGCCEI
TT2GAATAAA
AAAATTAGAA
CTATGCGTI'C
GCCCAATAAI
CACCGAGCCI
TGAAAAGATI
AAAAGCCCCI
TAAAGTGGG(
A.AAAG GGWX
TGAGCCTGAJ
*GCTTATGGG!
TTAATCAG1
CTGATCACAA
ACTTTGATIG
TTAACCGGCA
AGCCCCAAAG
AATTTAGATT
AACGCCITI'G
TATTGCGTGA
GTCCTATGCC
AAATTIGAGTG
TTGCCCATIT
TCTATCACGC
AAGCATGTGG
TTGAACGGTT
GATATTTTAC
TTATTCAAAC
AGCTI'GGGTA
CGCTATITrTT
TTAGTAGAAC
CTAGGCATGG
TATCCTAAAG
AAAATGCAAT
CTCATCGCTA
GCCTTATTGA
ATGCCAAAGA
7TACGAACGC7 TATIwrCCA
?GAAAAAGGGC
k CCAACACAAG.
;CWrATCAAAG r' TrAGGCGAAI k AGCTT'GGTG( r GAAATGAGT(
:CCTACCAGAC
CCCCCATITA
CGGACACTTT;
CCGACGAGCA
CTTACGCCGA
ATGATGGTTTr
AAATCATGTT'
GCTGTGAGAG
CTGATTGCTT
CGTATGAAAA
ATCGTAAAAA
GCACGAGCTT
TGTATGTTTIG
TAGACAATAA.
GCTTCCATGC
AGCTCTGTGT
ATGTTTTAGA
TA'I GCGTGA
GGATTAATGC
CTAAAAAGTA
AGCTAGAAAA
TGCATAAGGC
AAGAAGAGCC
.GTTTGATCGC
,GCGCTATGAA
ITTTr'rAAGGC
AAATI'GAGAA
AGGAAGCCCT
AAAATTATAT
AAGCTCAAAG
ATCGTTTGAG
GTCAAATGGT
AGGGCATGAT
AAAATG
L TATGTGAAT
LAAGAAGTAT
~GGGCAAAAG
E'AGCATTAGC
L'ATCCGCACC
rGAAAAAGGG rTATTGCGCG
;AGAGAGACC
GCcTTTATG CGAGGTAAC
TGAATGGGGT
GCTGGACGCT
AATGGCGCAT
CAVFITATTGG
GCATGGGTGG
CGCTCAAAAG
GGTGCCT1ITT
GAATTITGAAT
-rrCAATTAT
AGCACATCAA
rTl AGAGGAA
GTGGGTCTTG
AAACACGCTA
ATTAGCGAGC
TAAAAAATI'A
AATTGAAAAG
AGCAGAAAAA
TAGTATTGAG
GATTGAAAAA
GCAGATCATC
GTGCGTGGTG
rIWITAGCGGTG AGGAAGTTT1G 120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1140 1200 1260 1320 1380 1440 1500 1560 1620 1680 1740 1800 1860 1920 1980 1986 INFORMATION FOR SEQ ID 140:1413: SEQUENCE CHARACTERISTICS: LENGTH: 1026 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) AMEIJD~ 5 2_7r PC T USI-1 96/09 1 z RAMNS ib DEC 6 993 (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE- NAME/KEY: misc_feature LOCATION .1026 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1413
GGACGCATGA
ATTGAGGGAG,
AAAGACAAAG
ACGCAAGATT
TCCATTTACT
CATAGCGGGG
AGGCCTGCTA
GCAGGAGCGA
GAATACGCTA
GAAGAAGATA
GACTTITI'
GTTTGCGATG
ATAGGCTCTA
ATGCTTAAGA
GCACCGC'Tr
GCGGTI'GAAT
ATTACTCAAG
GACGCT
TGAAAATTGT
TCTCAAGGGC
CGACCCCT'T
ACA?1'AAAAT
TGGGCATGGA
CGACTATGGG
TTrGCACTr
ACACGGATITG
AAAGCGTGTT
TTAAGGGGAA
ATGGCAATGT
GC'TrATGGG ,rrrrrAAAGA
ACGCGTI'TGG
TGGGCGTGAA
GCGCGATTI!A
CGTrTGAGAG
AATAGAC'ITA
TTTAGAGAAT
TATTTCTAAA
GGAAGAAGCC
TATTI'TAAAA
TTrAGCGACC
AATGCCTAGC
CAAGCCTGAA
GCATTATGAC
TACGCTCGTT
GGAGGGGAGC
GAATGTGGTC
TGAAATTAAA
TATTTTAAAA
TAAAAGCGTG
TCAGGCTATT
TTTGAAATCT
ATGGGGGCTG
AAGAGTTTTA
GAGTTAGCCA
GCCACTGAGG
AATGGGGCTG
T'rGCGTTTAG
GTI'GGCAAAC
TATTTGATI'G
AGCCCTAAAG
AAAGAAACGC
GATATTTTCA
TrAAAGACAA
AGCTCTTTTA
CAAAAAACCG
ATCATTAGCC
AGCGCTGTTG
CAATCTTTTG
ACCATGGGGT
GCGTGGTTTT
GCAAAGTGGA
CGATTAAGCG
ACGCTTTGAT
GGCGTATCAA
GCCCTAGCGT
ATTTGCTCT
TGGGTCTT~l~r
ATAAAATGTT
AAGGGGTI'GT
CTGAAGGGGT
AATCTAAAAT
ATTACGCTGA
ATGGCAAGAG
AAAGTCAGGT
AGAGCCAAAG
TTrACCCATI'
AGTGGGGGAT
AATGATCCAC
TAAGGAATCT
TTCAGCGGGG
GGGGGTTGAA
GCTATTAGAC
CATGGGGTAT
GAGTAATGGT
GAAAGCTTAT
GGATGTAGTG
CGCTAGTGCG
GGGGGC
T
rrrG
ATATGGGGGA
CAACGCTAGA
TTGTTTGAGG,
CGATCAACAA
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1026 INFORMATION FOR SEQ ID NO:1414: SEQUENCE CHARACTERISTICS: LENGTH: 759 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY.: misc-feature LOCATION .759 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1414
AACGCTCATG
AGAAAAGACA
TATGAAAACA
GAAGTTTCAC
CCCAAAGAAT
ATCGGTGGGC
GGAGGGTTTT7.
ATGAGCGCGG
GATAAAGCGA
CCTTI'ACCCA
ACACCTI'GCC
ACAAGCCTGT
AAAAGCATTT
ATTTGCATGA
CTCAAGGCGA
GCCCGCATGG
CTTATGCGGC
CCGTGCAGCT
TCCATTTAGC
TTTTAAGG
AAGCGTTGAT
AAAAGAAGCG
CAATATCAAG
TGCGGGTrG
AGGGGGAGCG
CCGCTATGTG
TGCTTATGCG
GCACCAGCTC
CCTGATGGCA
ACGATTGTCA
GTGATTGAAG
TTTTTTATAA
ACAGGTAGAA
TTTACCGGGA
GCTAAAAATI'
ATTGGGGTGA
GCTTTCGCCT
AGTCTCAAGT
TTTCCACCCA
AGATCGTGTA
ACCCTACAGG
AAATCATCTG
AAGACCCTTA
TGGTAGCGAG,
TAGAGCCTGT
AGCTCAAAAA
GAGCGTGCGT
ACATI'CCCCA
TAAGGTTTTA
AAAATI'CGTC
GGATACTI'AT
CAAGGTGGAT
CGGGGTI'GC
GTCTATI'TAT
120 180 240 300 360 420 480 540 AsT/1 96 0912.
JPENUJS 18 DEC 1996 GTGAACACGC ATAACACGAG CAAGCATTCA AGCGCGGAGT
TGGAAAAATG
GTTTTCAAAC TC ACGCCAAA AGGCATCATT GAAAGCTTGG ATrITGTTAAG TCGCTCACTI' CAGCTTATIGG GCA ITTTGGG CGCGAGTITAG
AAGAATTCAC
ACTAACAAGG TIGAAGAGAT TAAAGCGTTC TTTAAGCGT INFORMATION FOR SEQ ID No:141 5 SEQUENCE CHARACTERISTICS: LENGTH: 435 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-.feature LOCATION I1.. .435 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1415
CGTGAAATCG
ACCCATrAT
TTGGGAAAAG
TCAACAAT'C
GCACTI'AAGA
GTGGTGGCCA
CTCAGAGAGA
GTTATGGTT
GATCCCAAAC
AATGCGGTGC
ACAAGGAGTr
AAAAAGTGGT
TGAAACGCT'
GACCC'TTI
TAGAAGGCAA
TCGCCCAAAA
ATGGGAGCGA
TAAATTGAAA
AGGCAAAACC
GCATI'TGAGC
TAAAGATTTG
AGATGCGGTG
AGGTACTATC
TAGCTTGGAA
CAAAGAACGC
ATTGATCGCT
GTGAAAGACG
ATAGAGTTA
GCTAAAAACA
AGAGCGGAT'
AACGCGCACA
TGTCTATrAT TrGAGAGTAA
CTGAAAACT'
TGGTGAGTGG
GAGAGCTI'AT
TTGCTGAGAG
ATGAAATCGC
TAAACCGGAT
CGGCTTGGAA
TTATGCGATC
TCCGGTGGTG
GGGAGCGACT
CAITGACGCT
TTTCTTrITr 120 180 240 300 360 420 435 GCCGCTAGAG AGTIT INFORMATION FOR SEQ ID NO:1416: SEQUENCE CHARACTERISTICS: LENGTH: 579 base pairs TYPE: nucleic acid, STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NQ
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .579 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1416 GGGCGAGGTG GAA'TTTATAT TGAACATGGC CTTTCAAGGG TTTrTGG'rrC TGTGGCTGGC ATCAACGCTC TTTATGTTAA GATCTTI!AAA AGGGTTAAAA TGGTAGCTTT AAGCAACGCT TATAAATTCC CTTCTTAT
CCAAAAAAGC
ATTGATTTGA GCGAGTTTGA GCCTTTAGAA IU91,)- JPENIUS iDEC M6
AATTATAAGA
AAAGCCCCTA
GACAACGATA
GAAATCAACC
TACCACCACT
AA.TACTAC
GAAAGGGTCG
QTTTGAACGC
ATATITGCAT
GCGCTTTACA
CCTTAACCC
ACCACGCCCC
CAGTCA.ATAA
CGC?1'GTTGC
TCITTTCATG
TGcGccITGC
AATTAAAGGC
TTCTTrrc
TTGCGATTTA
GCCCTCATTA
AAAAGACGAT
CGCTCTTTAA
GATGc1'TTAA ATGcccTATA
TATGTGAAT
GAAATTTTAG
C.AcAAAAACA
TCAAGGCAA
AAAAAGAACG
TCACTGAATG
AAGCGCATGA
TTTACCTTTC
AGGCTCGTTA
AAAATCTGTT
CCCCTTTGAC
CGCTITTI'A
ATTAGTGGGC
GCCCAAAGAT
T'ITTCGGGG
TGTGGGCAAT
240 300 360 420 480 540 579 INFORMATION FOR SEQ ID NO:14l7: SEQUENCE CHARACTERISTICS: LENGTH: 720 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1 .720 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1417
AACCATAATA
A ITGATAAGG AA4AGGCATGG
ATCAACCCT'
TATTTCAAGC
CCCATTGCAG
TTAGGGGTGA
TTTGATAAAG
AATCTTT1CAA
TATCATGGGG
GAGCAGATIT
GGCTATTTGG
AAGGGGCGGA
ATAACCCAAG
TCATTTTTAG
TAGCTITCA.A
GCTI7'v CTrC
GAAGCGTGGC
TGTrGTGGGT
AAAGGGGCTT
GGCTCTCGCA
GGCTrTrGC
TAGTGGCCAG
GGGTGGTGTT
AA
T
rTTCGCTA
GACGAAAAAC
CGTTTCAAAC
GCTITCGTTA
TTTGGCGCAT
GGTITTAGGG
GGCTGGGTfl'
GTTTTCCATI'
CCTI'GTGGCA
GTATTTGGGC
AGATI'ATAAA
TI'TTATFI'I?
TGGGGTTTAA
CGCCCGAGCG
GCTAT'rTTGT
CCTTTTI'TAA
TTrGTCGTGG
GATATTCCTT
GATTTGCTCT
CCTAGCCAAT
CTGATCTGCT
TTAGGGGTT1?
CCCGCTTGGT
TGGATGGTAG
TTGTGGGATG
TCATITTTAGG
GTTr GGCTIT
TATGGA.ATGT
ATTCmTACA
TAGGGGAAAA
GGCT1TrGTI'
CAGCCTTGAT
GGATAGAGAC
GATCAGCGTT
GAGTAATTTC
GGGGTATTCG
GGGTTTAGCC
CTI'TI'GGCT
GGATATGGAG
ATGGTGCTTG
TGTGAAATGC
CTITACTCTAT
TGTGAGTAAT
CAAGCATGCA
120 180 240 300 360 420 480 540 600 660 720 AACATTCCTA AAGCCTTTT ATCGTCCTTG
ATGTGGGGTT
INFORMATION FOR SEQ ID NO:1418: SEQUENCE CHARACTERISTICS: LENGTH: 552 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECU LE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature IPENUS 18 DEC 1996 996 LOCATION .552 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1418
GTAATGGCTA
ATGCATGAGT
GATTTATCGT
GAAGAATI'TG
ACTCTGGAAT
AAAGAAAAT'
G LTTGCCTAA
GAGGGGAAAA,
CGCATGCACG
TTTGGGGGTG
TGGTTTTAAG
TTTCTIATGA
ATrGGTTAAA
TACTCAAAGC
TACTI'GAATT
AAAAACAAAG
TCCTAGCCT'
CCTTAGACAT
GTGT1TTTTA ATccCAAGCT
AAGGTTTATT
TTCTGGCTT
GCTGTATTT
GGAGCAAAAG
ccTGATAGCG TI'I GGCGTG
TAAGCGTTAT
rTTTrATCGT 'TrAGGGTITLG
TCTAAAACCA
GATTTTCAC
AAATTAGAAA
GATCGCATCA
CCTCAAACT
CCI'rGATGTG
AAACGCGCTIT
AACGCTCTTT
GCTTGAACGT
AATTAGAGAG
TCGCT1'TAGG
ACTATGGGCG
GCGTTCAAGC
AGTCCAGTGC
AGCGGTG ITA
TGAAAATGAC
CCTGCTTA
GCATGGGCTA
TTGCGTGTI'A
AGAAATCACT
CGAAAGAAAA
GCAAGGGATA AAGATTI'T GAT1'CCTTCA TTGTTGATAG GGCTTGAAAT TA INFORMATION FOR SEQ ID NO:1419: SEQUENCE CHARACTERISTICS: LENGTH: 345 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .345 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1419
ACGGGAGCAA
TTGGTGTrGG
ATGAGGCGTT
CGTTTGAGAG
GACAGCTCAT
TCCATGGATA
TCATGTI'ATC
TGTGCTTGGT
TAGAAAAAAC
AATTAGAGGG
TAAAAACGAC
AAGAGCGCGA
T'rCTAATGAT T1'GTTTATGG GGGGTA'T1'G TATCTI'AAAG TI'rAGATGAA TCCTATCAAG GCG?1'TGGAA GGCCTTTCTI' TCTTTCGCAC CTTTATAACC TTACTTAGAA GAAAAAATCA
TCGTITTAGG
AAAAAGAGTT
AAAAT1'ATCT
TAGAAAAAAG
AGTTGCAAGA
TrACT
GGCGATTTTA
TTACCATAAA
CTATTCTAAG
CGCTAAAGAG
AATCCAAAAA
120 180 240 300 345 INFORMATION FOR SEQ ID NO:l420: SEQUENCE CHARACTERISTICS: LENGTH: 1005 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: PluI/US 9 4, 191a~ IPEAIUS 18 DEC1996 997 (AY NAME/KEY: misc_feature LOCATION .1005 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1420
GAGCCCA'ITA
ATACAAGGCG
TATATCAGCA
GTAGCCATAG
GCTACAGGCG
AATT1CTGACA GGTGA7AAAGG
GTTAAAGAGG
CCTAACAATA
TITTTAGACA
CGCTTGCGCG
CGI'GCGCCA
CAAATCCTTA
ACCAGAGTI'C
AAGCGGTATI'
GCGGCGITTC
GAGA'ITGAAA
AAAGCGACAA
TATCACACAT
AAGGGTATCG
G ITTAGAGTT
TGCAATI'AAA
ACCAGAATCG
ATTTGAATGA
GAGAGCGCGA
TACAAGGTCT
GAGATCATI'A
TTAAAGATCT
GAGATITTTGA
TCAGCTACTT
TI'TATTCTT
TGGGCAAGAG
TIGTGCGTAA
AATI'AGCAAC
AGAAGCCTT
TAAGAATAAT
CAITGAAGAG
GGGCGAAGAC
AGGGCTGGAT
TCTATAAT
TF1'CATCAAA
AGTGTATTAC
TATGAGCGAT
'TTITACAT
CGTAAAAATC
AGAAGGCAAA
CGTGCGCCGA
ATACAGACAG
CGTI'GGTCAA
CGCTI'ATGCA
GCTGAACCGC
GATCTGGTCA
TATAAATI' E
ATITATGGCG
GATCCGCAAG
CTCATCCGCA
ACI'ATTGGG
ACCTAT1'TGA
GCGCTAAAAG
ATGCGAGAAT
CGTGGAGACC
AAAT'ITGGCG
TTGGA'ITATG
AGCGTGTGCG
CTAGGGGAAG
ATGGCG'FTCC
GCAAATCAAG
cAAAAGAAGA
TGCAAAATCG
TCACCAAAGA
CGITITITGTG
TGGTGTFI'GA
ACTAITTGAT
TGCC'TIAGA
GAATCTATI'
CCCACCACAG
ATGGCAGAAT
CGCAACAG T
TGGCAAAGCC
AAAACTI'CCA
GGGATICTAC
ATGTFI'CAGC
CTAATGACGA
TGTGCAAAT1'
GAAT
ATCGCATGAA
GCTTGACAAT
GCTCAAAATC
GAGCATCAAC
GATGGGGGAA
AAATI'GGCTI'
TGAGGATAGA.
AGACAA'TIC
C'iTTCAAATC
AGCGAA'TTA
CTTrGTrrTTG TGAAATCTrG
CCCTACGC'TT
CGATGCATI'G
TAAAATTAAA
CATCCTGCTT
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1005 INFORMATION FOR SEQ ID NO:1421: Ci) SEQUENCE CHARACTERISTICS: LENGTH: 282 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .282 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1421 TTCTATGTCT CGATCATI'AA GGTTITGCCCG, CCCTTGGGGT TrTAATGTGG GGGCATACGC GATCAATGGG ATTCAAGCTT ATCTTITC AAGCGCTCAA
ATGCACGCCT
CTATATGGAT
TTCAGAGACT
GAGTI GGGC
AGTCGCCACG
TrA'rTGGTCC
CCAATCCCGG
'rrGAGGGCGA TrGAATTACT
GCCAAGCCTA
AAATCGTAAT CGTGT1'ITAT CAG~CATTAT TGCGI'TI'CT GC'TTCTITC TGTCCCTAAA TGCAAACCTT T'TGGCATGTC
AG
120 180 240 282 INFORMATION FOR SEQ ID NO:1422: Ci SEQUENCE CHARACTERISTICS: LENGTH: 1383 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) iii) HYPOTHETICAL: NO P CT/ U 0 3. 9)/O91zz IPEAIUS i8OEU 1996 9983 (iv) ANTI -SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .1383 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1422 TCAATAAAAC ATTTAGGCAA ACTTTAGAAT TTTACGATT TTTICCCAA ACACGCTTAG GCAGGTTATC TGGCGCGCCC GGTCGTAAAA ACATGI'CAT GC2'TTGATGC CAACTITTAA CCTAAAAACG CTCATTIATCT TGTCAAGGCG TCGCTGTGGG GCCCCACAAG GACAAAAAAA ATTPTCTTI'GCGAG I TGGT GAAGA7IGGG CTTGCCGGGT TAITIGAGGC GCTTrTAGA ?I'AGTCAAAT TCCCGCI'AA ATGCITATCA C? GGGT1' TTI'ACCCI'A CGCATCCCAA CTAGGACTI'G TTGGTATGT AAACCGCACA AAGr1'TGCAT TTI'AAGGAAT T1'TAI'CTAA GCTTGCTTITT GCGCGGGCAT GCTAGAATCC GTTTTAGCGG GGCTTrrACCC CTCAACTI'C TI'GCAAAGTT ATGGTTTAAG TCGCTII'AA TGGCGCCAAT
GCA
AAAAGAGGTG
TATCATCTTT
CCCTATCTGG
GCTI'GGTGGC
GCTCTCTAT
TGATTrIGGTG TGGTrACATA
TGGTGAATTG
CACT'TATATC
TTATATCGGG
TGCC'TI'GGG
AGAAACTCCC
AGAGGTGT
AACCGCTTGT
771TI CATr1'C AAGTTCTA?1'
GGCTITI'AGC
CGCGCCAAGT
TATGAATTT
AAGCTGGTTA
CTITTATATC
AAAACCTI'AG
GTATTTA
TCTGAAATCA
ATAGTGATGG
TT'ATTAATGG
GG'I"ITI'GGCG
GCTCCTGTTI'
CCTGGCGCTI'
GGTTTTAA
ATTTACATGG
CT1'GGAGGAA
GTTITTTCAGC
AAAAATTCCC
ATTITGATT
ACTCCGTTTG
ATTITCACCG
GCGGCCTTTG
'ITAGTCAATA
TGCCCCAT?1'
GCTTATAACA
AACGCAAAAG
CTI'ATAGTTT-
GAT1TGTCTI'C
CAAGTATCAT
ACACTIATGG
CCCACTTT G
TAATCCCAAC
TGGATAGCAT
TITTGGTGCT
GGGT'I TrGT
CCGCTTCCGT
TITI'GACAA
TrTTTl'GGTAT
AAATGAAGCA
TCTTTGGTAT
TTATCCT1I171
AAAAAACCTA
GGI'TTTGGC
GGTTrGG
CTATAATTTT
TCATGAGCGA
TAGCCTATGC
CTATAGCAGT
CTT1'AA'ITGC
AACACGAAGT
GCTIGGTGGG
TGCCAAACAC
GATCTTTGCT
GGATAAATTC
CTTTGCGCTA
GGGGCTTACC
TGT1YAGGATT
CCATGAACAT
AGTITCTGGG
GCCTGTTGTI'
CATTTCTGTG
GGACGATGCC
ATCAATCTCC
TGTCCCGAAT
TTTCAAATT
TGATAAAATC
CT'TrTTATc ATAC'TTrA
TGTGTTI'AGC
TATAACCGCT
GCCTIGAAAGT
T'TTrATTACA
GTCGCCCACG
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1140 1200 1260 1320 1380 1383 ?I'ATCACAAA TCTAATACCC INFORMATION FOR SEQ ID NO:1423: SEQUENCE CHARACTERISTICS: LENGTH: 1521 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1. 1521 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1423 AAATCGCTCA AAAAGAAGTG CCGGAGCTIT TTGCAAGAAT ATGAGGI'TA TTGGCTTTAA TGGTAGCGG GCCAAAATAC AGAGGGGATT TI'GAAAAGCG ACGCTCAAAG AGATCCAGCA AAACGGCCGT ATCATTAT TCATTGATGA CTTTTAGGTG; CAGGGAGCAG TAACGCTGGG AGCI'GGATG CGGCGAATAT rrCTTTGGAT
CCTGAAAAAA
AATCCACACC
ATAAAACCG
POUS 9 6/ 0912a.a IPENUS 18 DEC 1996 GTTTAACGG -ATGGGAGCTr GTGTITTGAAA AAGACAAGGC TCTAAGGAAG CGTGTIACT CAGGTGCGTI' ATAATGAAAG CATGATAAAT TCTI'GCCGGA AAGATCAACC CTAAAAAAGG CTCAAGC ETA AAATCCCTAA 'rrGGAAAAAT CGCTAAAAAA AATGCGATCA AAATCCAGCA TITATTCGTGG GGCCTAGTGG FI'GAATI'GC A'ITTTGAACG AAGCTCATCG GAAGTCCTAG GCGATTAAAA AGCACCCGCA AATGTGTAT1G ATTI'GTrGTr AACAAGGCGA GTITTAAGCA.
AAGGACACGC TAGGGT1TI' CTITTAACCC CTGAATI'GCG TTGGAGGATT TrGAACGCAT GAGCAAGGCG TGATCTTAAA TACCAGAGGA GTTTTGGTGC CAATI'AAGCG ATATAGTGCT AAGAGCACAT TTCACAAAGT
GAAATGTTIG
TII2CAACAGG
GATITTAAAG
CGTGTTTAAG
TAAGGCGAI'
CAAAAAAATC
AATGCGTA
TAAGM-Trr
TTGCGGGCTT
GGTAGGGAAA
CT1TGACATG
CGGTTIATGTG
TTGTTT'GCTG
GCAGGTGATG
TGTGATACTG
TAGCACTA7A
ATCCAGAATT
TGTTCGT
ATI'CCATAAA
GAGAGAAATI'
TAAACAATCG
G
GGGGCGACCA
CGCTIr1CTA
AATATTGCCC
GCATGCGTGG
GAA ITAITAG
AGCGI'GATG
AATAGCGATA
GCCCAAACCG
TCTGCAAAAA
ACAG;? %?I'GG
AGCGAATACA
CTIITAGATG
GATAACGCCA
ATTATGACTT
AACGCCAAGT
GATGCGATCG
GAATI'GGACG
GAAG 1TGTGA
AAAAAAATCA
CTTAAAAAAC
CTTTTGAAGA
TAGT'GAATGT
CCCTTI'ATGA
ATTTGACGAG
ATGAGGTGGG
ACGTGCAAGA
AAAAAGCCCT
AAGCGATCAA
ATAAGCCTGT
CTAAAGAATI'
AAGAAGCCCA
AAGGCGGGTT
AGATAGAAAA
CTTTGAGCGA
CAAATGTGGG
ATGATAGAGC
TGCCGTrAA
GGITAAAAGC
AATGCATCGC
ITCAGAGGGA
CAACAAGATC
ATACCGCAGC
TGAAGAGCCT
AGAACACCAC
CTATI'ACATG
ATCAAGGAAA
AACGCTCGCT
T1'IAAGGAAT CC ETGTCAGC
GGGGAGCTTT
GGCCTTGAAT
TAGCGTGGCA
ATTGGTGAAT
GGCCCACCCT
TAATI'TAGGC
GAGTAAGGAT
CGTTAAAGAG
CGCGCTCAGT
CCTAGCAATA
GCAAAAGAGC
AATCAACCCC
GTTGCGCATG
300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1140 1200 1260 1320 1380 1440 1500 1521 INFORMATION FOR SEQ ID NO:1424: SEQUENCE CHARACTERISTICS: LENGTH: 534 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .534 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1424
GGAATAAAGT
TTAGCGTTCA
GGGGTGGAAG
ACCCTTGCTA
ACCGTCTATC
GCTGATATTT
GGCTGGCGGA
GAGAGCGATG
GGCTI'TTTTA
TGATAAAATT TGTGCGTAAT TGCTI'TTAGT GAGTTATI'GC TCAAAAGAAT GAATGAAAAT GAGATGTCTA TTITGTGCAA GTAACGAAGA .CACGCGCTT CAGCTCTCGC TCAAAGTA TCAATTTGTT TAACATGTI'C AGATGTCAAA ACCCG TT TCAGTGCACG, TTCTGITTGC GTGGT1TTTAT
ATGCCCCATT
GAAAACACGC
ACTTACGACC
GGCTI'CCCTT
GTCAATCAGC
CCTAATGTGA
AGCTGGA'TDT
ACTL'rATI'TA
TCAITYAAC
ATAGCGTGGC
CCAATAATAA
CTAAGGATCA
FrlTlATITiTwAA
AAGTGGAAGT
T'TTrrTTAAA
TATACGCCCT
AGGGCAAAGC
AGCGATCT'1
TGTCATIAGC
GGAAGTAAAA
AAAAAGCGTG
GTTTAAMTCG
GCAATACTAT
ACCCTTAAAA
GCTACTAGTG
TCAT
120 180 240 300 360 420 480 534 INFORMATION FOR SEQ ID NO:1425: SEQUENCE CHARACTERISTICS: LENGTH: 1914 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular
A)
1 PCTIUB- 96/U91aZ IPENUJS 18 DEC 1996 1000 (i)MOLECULE TYPE: DNA (geriomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc..feature LOCATION .1914 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1425 GCGCGGCTI' TATI'GTATAA TCTTAAAAAT CAAGAATACA CCTI'CCAAAC TGAAATCAAC TA ITCTAATA AAGAGATITT TI'AAGGGAG AAGCTGAATT ATTTGATGCT AACCGATGAG ATCCATTI'GA GTITTrATAG CCAAAAAAAA ATGGATAAAA GCGATCTCAT CGAGCATTTA 1I7rTAAGCG CT 'IGAGTGG GGATAAGAAA GTGGGCTI' AT'rCGGCGTT CATGGTAGCG ACCAGTCATC AAGCTI'ATGC ATCGGTGAGC TGCGTCAAAG AGGAGCAAGG CACAGAAATC TrTGCGAGCC GTTGGGAGAT TGATAGCGTI' CCTAT IT?1 TAACTTACAC CGATACGAAA GTI'AAAGAAG AAAAATGCGA TCAGATCAAT AGCGAATTGA AAGAAAAGGA TTACAAAGAC GAGCCTGA GCTATATCCA TAATAAAGTG TATATCCCTA GCAAAGCGCC CTTTGATI G CTrrATGTI'A AACGGGTGTT TATCACTGAT AGGTTM'TIA AAGGCGTGAT TGACAGCGAA TTIACAGCAGA ATAAGATTTT AGCCAATATC GAGATI'GAAA GGCTGAGCAA GGATAACAAG AAAGTGTI'AA AAGAAGGCPT GTATGGGGAT TrGAGArrTCT ATTCTAAAGA CAAAGGAGAA 'rrAAAAGAAAt ATCAAAAAAG CATTTACTAC GCGTCCCCCC TITTAGAAAA ATACGCTCAA GAAAT GATG CGTTIGTGAT GCCAGGCGTG GCTAGCCATA GTGAGAGTT1' GAAAGAGCTT GATCAGTTTA AAGATTTAAT CAAAGCGI'T GTAGAGCmT CTGGTCATCT CACTTCAGCG ATGATGGCTA ATI'GGATGCG TCAAATGGGG GAATTAAACC CTAACCATGC GAT11TGCAA TTGAGCGCTr TITATCTGGTT GCTTTATGAT AAAGACGCTA AAAGT1TI'IAA CGAACGCCTA TrATTAAAG CAGCTT1'TGG
TTGATI'CTA
AAATTAAAAG
ACCTI'AACGA
GGCACGATCG
AAAGATAGCG
AGTAAGATTG
GATGGTAAGG
ACCCTC'1'7iT
GTTAAAAAGT
TTTGAGGGCG
CAAGCGAGCG
TITrACCAAT
GAAGGCTCTI'
ITTAGGGTGG
GATGACAAAG
GXITI'GCCCT
CGTTCCGCI'
AATTACCATA
TTGAAAACA
TGGATTTCTT
CT1TTAGGCG
AAAGGCTATG
AATGAATACG
GG?1'TGGCAG
GAAGAAAATC
GTGGCTTTAA
CAAAGCGTGC
AAACTCTTAA
GGGGCGAAGC
AATAGCGTGC
GAAAAAGITC
ATrrGATGAT
ACGCGAGCGA
GGCTGAATAC
TTAAAGACAA
CTAAATCAGG
CCTTAATTGG
TCGTTCAAAC
GCAAGI'TGA
TAAAAGAAGA
ATTCTGAGCA
AAGGGGATAA
CTTTATGGAA
CGTTTGCGCA
TAGAATACAC
ATI'ATAAAAG
AATTGTTGCC
TGAACGTGAG
CAGTGAAAAA
AATTCTATGA
AAGAAAAACT
TAAAAGAATA
AAAATTTAGA
ATGTTTTGTT
ATAAAACGCC
AAATCCATGA
TTAAAGATGA
TAGGCGATGA
CTGAAAGCAA
AATGCGAAGA
TITTAGAAAA
TATGAAGGC
AATGTCTAAT
CCACTCTITG
CGCTTTGGAT
CACGCCTAGC
TGGTATAGGC
CACGAAGAGT
CCAATTTGGC
CAAAAAAGTT
AATCAGCGAA
AGATTCTCAT
TATCCCTTTC
TAAAAAAGAA
AATGAATAAG
TGATAACAGC
GACGCTTr
CGGGGTCAAA
GTCT1TATTl'G
TCGTGAAATC
GATTTI!AAGC
GCCTTTITGGG
TTTAGAATT1G
CAAAGAAAAT
CTTATTAAAA
ATTGAGCGAT
cTTTAGAGAC
TGAGGTAAAA
GATITAAGGGC
ACCAAATGCG,
GAAAACTTTA
TAAAGAGCAG
AGGGGCTTTA
GTZG
120 180 240 300 360 420 480 540 600 660 720 78a 840 900 960 1020 1080 1140 1200 1260 1320 1380 1440 1500 1560 1620 1680 1740 1800 1860 1914 INFORMATION FOR SEQ ID NO:1426: Wi SEQUENCE CHARACTERISTICS: LENGTH: 1275 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: 4i IV777 0912?_a 1PEAiUS DEC 1996 1001 ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .1275 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1426
AAGCAATTTG
CI'ATAAAAT
AACAAAACAT
CAAGAAGATG
GTCAGC'TI'G
GAAATCCCCT
ATGCAAGAAA
GCTCCAAAGC
TCAGGCAAGG
AATrTAAACC
ATGATGGGCT
TTAAAAGCTI'
CTCATTTGGA
TGGGGGGATr
ACGCTAGCCC
AGTTTIAGATG
GGCATTGTAG
TTTGGCTCAA
CTCCCTTITAG
CATCCCACTA
TTAGACAAGG
CATGCI'ATT
GTAGGCGAGT
TCCATGCCCT
GCTATAAAGA
TCTTAAACGC
GI'TrGTTAA
CAAGCTCTGA
AAGGCGTGAA
CCACCACTAA
GCGGTGTGGG
AAAAAGTGGG
TGCAAAACGC
TT1GGCGTTrC
GAGGACCCAT
TAGACGTGCT
AAGCCGTGCC
ACGCTAAACG
AAAATATGGG
ATTCCATGAG
AGCCTAAAGT
GCGTGAGTGC
TGGAAAGGGA
CGCAT
T'TACCCAA
ATCCTTTAAA
AAATI'CAAAT
GTTIAAAAACG
AAACATCACC
GGAAACGAGT
AGCTT TGAAT
AAATCTGGCT
TAAAAGCACC
GCTACTAGAC
TGATGTGATC
TGTGATGAGC
GCTCATGCGA
GGTGGTGGAT
ACTCAGCGCA
GAG TTGGAC
GAGTTTTIGTG
TGGA ITAFI'A
GCGTCTAGGG
TAAAATTTI
AALAACTAGCC
ATI'CCTAAAA
AACGCAAATT
ACTATCA LTr
ATCATCTACC
TTGCATGACA
GCGATTTTAA
TTGGATATTA
AAAAACATCA.
ACCAGCGTGA
GCTGATGTGT
ATGGATCCTA
ATGGGGCTT
GCGATTGAGC
ATGCCCCCAG
GGAATCACCG
ATGTITAAGA
TGCGAGCATT
GAGGCTTATA
GGGGATAAGG
GAAAAAATGG
GATAATAAGG
TGGTGCAATT
TAATTATAA
TAAGGArI'AA
CTAATTTI'GA
ACCAA'PTAGG
GGGAAAATAT
AAACCCCGCC
AGCATGTGGT
ATTI'AAGCAT
ATGGCCCTAA
GCGGTAAAAA
TGTATGATGA
AGATGCTAAG
GAACAGGCGA
TI'ACTACGCC
AACTACACAT
GCAAGAAAGA
ACACCCAGAT
GTGAACCGAT
CAAAGGATI'
ACATCCAGCC
TCAAAACACG
TGCAAAAI'A
AATGCTCACC
AAAGGATAT'r
GCTTAATA
CTCCAAAGCG
TAAACCGCAA
CATGATAAGC
CGCTrAGCG
TATCCCTAGA
ACTCATTCCT
GGCAGAGT
CGATATI'ATI'
TGCGCAGCTC
TCAAATCGTG
TCCTATTGCG
GAGCGAGATTI
TTTAGCCAAG
TGTGATrCT
GAGTGCTTTT
CACACAAACG
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1140 1200 1260 1275 INFORMATION FOR SEQ ID NO:1427: SEQUENCE CHARACTERISTICS: LENGTH: 1329 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) VEATURE: NAME/KEY: misc-feature LOCATION .1329 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1427 CTAGGG 117 r AGAGTGC7GAT
ATTTACCCTA
CTCCCTAAAG
TTAGC?1'ATG
CCAGCGAACT
TGGACCAGAG
GATrATCAAT
II=AGCG
GTGTGGTTTA
TGGCTrGCA CGTrTCGCG
CAGGGAGTTA
GGAI'GAAAA
AI'CCACGAA
GGTATTIACAT
AGCAAAAGGC
ATAAGGACAT
GGTTTAATCA
GCACCI'TGG
TGGGI~r
TATCGCTITC
TGTAACCACT
CCACAAATI'G
GGGGCGATGG
TCAAAACGCC
1ITTGGATT AGGG EI'AG
AAGGGCI'TTA
CTCAGCGCTT
AACCAATCGA
ACCGGGGCI'
GGTITTGGGG
GATGAAGCCA
GAGGGCTA?!'
AGGCCTI'ATG
AAACTAGGGC
A 'I'ITIACC
GCCAATGAGC
T'rGAGTATCA
TCATCAAI'C
TACAAGTTGA
TGGGGGGCGA
ACCCTAAGGC
TGATGCAACA
TGTTATACAA
G'ITACCCTTC
GGTGGAAAXA
AATACATI'AG
AGTGAGCGCT
CAAAAAAGGG,
TTCTAGTTTIG
AATAGGAGCG
AGGGTI'TCAG
CAGCCAAAAT
TTTGTAITTA
TAAGGCTTG
GTTAAGATA
GGATIT1'AC I POU S I, 69 1U 4_ IPENIJS DE1JC 1996 1002
GCTCCTGTCA
GAAAATAAAT
CCTGGAT"I O
ACGACTTI
GCCGCTTTAG
TC'ITATCGT
TGGAATGGCT
GCT1'ATCCA
ATTAAGAATC
CAAAGC 1TAG
G'ITAATGGCT
TACAACCCTG
TATCGriTi
ATACAAGCA
ACATTAGGAT
AAATCACCCA
ACGCATGGT1'
TGGGTAAAAA
TTGGCTGGAG
CACCCAITGA
A'I=ACAA
TrGGTGCA
GGGTTAC'TI
ATCAAATCAC
ATTI'CGCTCA
AAAAATCAAC
CGCGCCTT
TGACACAAAA
TCCTCTCTAT
AAGCGCGGCT
CGTGTATAAG
TCCTrrITrAC cGcTAATTCC
AITTTATG
TAAATATAAC
GATGCATAAG
AACCATTCAA
TACGGCATCC
ATITTGGTTT
TCI'ATTGGA
AGCGACTAT
TTGTrI'GTGT AATITrTGGGA
GACACGAAAG
ATAACGATTA
AAATrAACCT
CTTAAAAAAC
GG'ITATAAGG
AATAGAAGCT
ACA.A TCAA
ACCCTAAGAA
AATCTCTI'TG
TGTCTAAAGA
TTCAAAGAGT
ACGCGAGCGT
ATGATACCCC
ACGCTTTTAT
A'FrCCCCAAG ATATCTA'TrT
TAGGGTTTT
ATTTGATGAG
CCTCGTII'AC
TTTTAACGCT
GCGCATCCAA
'rTATI'ATAGG
GAATTTCCGC
TCAGTTAGGT
?I'ATGAAGAC
AGGGAAGAGC
GGCTGATGCG
CATGCTAATG
TACAAGCGGT
CTCTATGAGT
660 720 780 840 900 960 1020 1080 1140 1200 1260 1320 1329 INFORMATION FOR SEQ ID NO:1428: SEQUENCE CHARACTERISTICS: LENGTH: 414 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .414 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1428
TACCCTACAA
CTAATGATA.A
GCGACTGGGG
ATGAACGATG
GCGACTAAAA
CATGAATTAA
TTAGAAGTTA
ATACTATTAT
GCGGTGITI'G
GGAAATI'CAT
AACCGGTCGT
AAGTAGAACC
AATACTCGCA
AAATCATCAC
TGAAAGGATT
TGTGGGGGCA
GGGGAAAATG
GATTAAAAAC
CAAATITGGC
ACAGATATTI'
GGACAAGGGC
TTGATGTTI'A
AAGGATT1'GG
ACGGACTCTA
CTTAT1'GTCA
GATAAGTTITA
TACCGCCTOG
GAATATTACC
AAAAAATGTG
AITTTCAAGCT
GTCTITIAAG,
ATAGGGGAAA
AAAAAGAAAA
ATI'GCAAGCC
ATAAATTC
TTTGAGCCTG
GGATTATCGC
TATCACTI'CT
TTCAGTCGAA
ACTCITI'GAT
TAACCAATTIG
CAAA
120 180 240 300 360 414 INFORMATION FOR SEQ ID NO:1429: SEQUENCE CHARACTERISTICS: LENGTH: 1173 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (geflomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: OW.ANISM: Helicobacter pylori (ix) FEATURE: A1 POT/US 9 6/0o91 JPENUS 1.0t 6~~'96 1003 N.AM1E/' KEY: msc~feature LOCATION .1173 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1429
AGGATTGGCA
CCCAAAGAAT
GAATGTGAAA
AAGCATGCAG
CATITTIGCT
CCCTrTAAAC
GGGGGCGTTG
CTAGAAA.AAC
TGCGAAAAAG
CTCATITTTAA
GATACGCTCG
TGTrIGACC GT1'ACACCAG
GAGAGTGA
GAATCAAGCA
GAAAATATFI'
GATGCGCGAT
AGGATCCATG
i'rTTTGGGGG
TGGACGCT
GCGGTA11rI
AAAATCGCGT
AAAAAGAACA
TTGCAGGGCA
CCATCATI'AA
GGGCGT'TT~
TACTCACGAG
TCAAAGAAAA
TCTTAGGCGA
AAGGCGI'CA
C'ITCAGTTrT
CTTCAAAATI'
GGAGCGTAGA
AAGAATAT
GTTCGCCTTT
TAAAAACATG
TTMAGCGC
CCGTTGATGA
TTTTrAGAGGG
AGAAATCACC
TGAATACATI'
GAAAAACCTI'
TGCAAAAGAA
TATIGATGTC
AGAGGGGT1T'I
GAGTGCGAGT
CGATGAAGAA
GGA'I'ITGCTG
TAGCATCAAA
AGGGCATGTG
GCCTCTCATT
AGTCATCACC
AATTGCC TTT
GGAAAAGGTT
CATCACGGCT
CCACACCACC
TCATGGTATA
AAGGGTGAGC
CTTGAGCGAG
CAAAAACTCA
AAATCGCTTT
'FI'TITATACC
AAGCATGTAA
GTGCCTCCTG
TTATACGGTC
TTAAATITTTA
GGGCCAGGGA
CCTCATATGG
ATTGGCCGAA
GC'ITACCCGC
TCAGGAGTTC
AACTI'GCATG
AATGCGCGCC
TGAAAGATI'
TCCCATTCAA
CCCCTTI'TAA
GAAGTGGTGG
TI'GAAGGAAT
AAA
TCAGTTACCC
TrCCTGCTTT GCATTrTTTAA
AAGAAAATGT
GGAACAATrG
GTGGGGCGCA
ACCCTAAAAC
TTITITGGCAC
CGATITGTGGC
GAGGCTCTAT
AAAAATGCCA
ATT'AGACAA
CAGGGTTAGG
ATTCIITAAA
TGCCTI'ATAC
AGCTI'ACTAG
ACACCAAAGG
AGTTTGGCGC
TAGAGCII'.
TACCATTACG
TAAAACCCTA
CCCCCTCAAA
TAAGCCCT
GCAAAGTGAT
AGACATGAAG
CCCTT7I'
TAGGCI'ATG
TGAACCCACT
TAATIGGCAAA
AAACCCTATI'
TGGCGATGAG
GGCTAATAAT
AACCACCCAA
TTTAGAATTA
CGTTTTACAA
CGGCACGAGC
CATTAATGAC
GGAAAAAGTG
120 180 240 300 360 420 480 54 0 600 660 720 780 840 900 960 1020 1080 1140 1173 INFORMATION FOR SEQ ID NO:1430: SEQUENCE CHARACTERISTICS: LENGTH: 2784 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc-feature LOCATION .2784 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1430
ACAAGCCT'G
GAAGTCAGTC
CATGTAGAAG
GACTATTCAA
TATAGAAT
GAATATGCCA
AACAATCAAT
CCTAATAAAG
T1'AGCAAAAA
ATGGAAGACA
ACAAAATTCA
CCTATCAATG
GATGAAATAA
CACTGCAAAA
AAAAATATCC
ATCACAAAAT
ATAA'ITTAAA
CTrI'AGGGGA ATA'TrGCAC
CATTITTTAGA
ACGTAACCAA
TGGTTAAAAA
AATACAAACC
TTTATTCTCA
TCTTIAAAAAA
CACCAAAAAC
AAAAGGXTr
ATGAATGCAA
AACAA.ATATG
CACAGATTT
GGAATTATCA
ACAATGCAGT
TI"ITATAAA
TAATCTGCTr
TTTTTATCAG
CAATCAATTT
TTTAAAAGAA
GCTAGAGGAA
TGAAATTAAG
ACGGCAATIT
TGAGCGAAAC
TAGCGAAGAA
CAAAAATTAT
TCI'IGCGTGG
AAAACGCTAA
AACTrCGTI'r
GATTATAA
GATAAATTAA
?1'CAAAAAAT
TGTATAAGAG
TTATAATAG
C?1'AGTGCA.A
TTAGATAAAA
GATATTATTA
AATGAGTITG
AAAGAGTCGC
GAGCCGGAGT
ATAGAAAGTC
ATTTGAGGAT
TCAGCTATCC
CTATTCCCAT
ATCTTATAGC
AATTIGAGCGA
TAATCAAACA
AAATTATAAA
GGAAAGGCAA
GTGAAATTAA
TTTTAAAAC
AAGAAATAGA
AATCAAATAT
TGATCCGAGA
ATAAGATI'AA
ATGCCGI'AA
CCAATCTAAA
TTI-rGAAAAA TAACAATG3AC TC TACAAT
GCTTGTAACT
TTTAAGCGGC
ATACAACGCC
ACAAAAACAA
ACCACAAGAT
TACCGACTTI
CGAAAAATAC
TGAAAAACAT
AATTGAAAAT
TGATCTGSCTC
TGATGTGTCT
PCIUS 96/U9127.
IPE4IJS A DEC 1996 1.004
AAAGATATTA
TcAGAAATI'G
GAGAGTATAA
GAAATCAAGG
GAGTTCGCAG
ATAAATAATG
GAGCCAAAAA
AGCCAATTAT
CCTAATAAAA
GATTTAGAAA
GAAATAGATC
AAAATAGAGA
ACAAGITI'C
AAAATAGAT'
CCCCAAGATA
AAATATACGG
AATGAGCCAA
TTrGGCTITC
ATGGACGAGC
AAAGAATACG
GTGGATACGG
ATI'AAGAATC
AAAATCAAAC
ATCATTTTG
CGTI'ACAAAG
AAAAACGATT
CCTATGTrI' CGA'TrAAAA
TGCGATAGGC
GCTAAAAATA
GAAGATGCGA
TGGGCTACAA
AATCCATGAT
TGCGATACAG
AAATT ITAGA
ATAAATI'TGA
AATATTGCCG
GTTTATCTCA
TCACAGATAA
CTGGGCACTG
TTTGGATTCC
TCTATITI'GA
AAGAATCACT
GTAAGCATGA
'ITTTTGCTAA
CTrTAATTAC
GTTACCAATI'
AACATGAAAT
TCATC?1'AAG
TT'TATAATGT
CAGCCACTCA
CTCATAAAAA
ATCXITI'AGA
ACTTTAACTA
GCTCITTTAGG
TAGAAGGCAT
AATACAAGGA
CAAACGATAT
TGACAGACGA
GAGCTAATGA
ATTI'CAAACA
AGCAAATGGA
TAGAAAAACA
ACI'GATCAA
ATACAGCAAT
TAATGAAAGT
AGCAAACAAG
AGAGTGTAAC
TCAATTTGAA
TACCTTGAA
GTTI'cAG ITrAGAGTTC
TAGTCATGAA
AAAAAAGATC
TAATAACGAT
AGGAAGTTIT
AAAAGAATT
AAAATI'CGT
AAAACTT1GAA
CCAGCAAAGC
GGGATCACAT
TTGAGCGTG
TCATGT'IACT
TGAAATAAGG
TCCCCTAAAT
AGTGGGCCAG
CACGGATTAT
CAACCCCATT
GAAAGAAACC
TGACAGAAAA
AGAAATGCAT
AATTGAAGAT
ATTGAGCATG
AACAAAAAGA
AAAC
C7'rTT'GAAC
GGCA'ITTATT
GAAAA4ATTCA
CCCTATACAG
AAATrCGTGC
GCCATATCAA
CTTTCG'ITAT
AATAAAAGAT
TCGTTCAATA
AAACAATCAA
ATACTGCAAC
GCAGAAATTI'
AATAAGCTT
GTCCGACATA
GT1TIATGATF1
ACCGGCTTCC
rr'rAGTTTTA
CCAGCCAGAA
TTTG'T=rAG ATrGTGGAAA
AATGCAAGCA
CATGITI=C
TGTTATrGA
CCTTTCACTT
ATTGAAAAAC
TGCG TMA
GATCCCATCA
TGTTTCAGCG
GCT=IIAAAA
AATTTTTAA
AGATAGAI I
CAATACAAAG
TGTTICCCTAA
AACAAPLGCAA
CGT'rTAACI'
CAATCATGAA
CCAAAGACAC
TTAATAAAAC
CAAAAATAAA
TCTCTAAAAA.
AAGATrrrl'T TT~GAATrrrTT
TAGAATACAA
TAGCGATCGT
ACAATAAGCT
GCAGAAAATC
AATGGGCGI'
ACCATAATAT
AGGAGTTI'AG
CCACCCATGA
AGGAAACAGA
AAGACTCCGA
ATAACCCCCA
GCGCTTI'AA
TCTI'ACCCAT
TTCGAGT
ACCAACAAC
CCATCCTACA
CAAACGATAG
CAAGGCI rr AATI'A'rCAA
AITAGTICAAT
ATCTTTATGG
AAATATTGGT
AAATG'ITTCT
TCATCTAAAT
AGAATACAAA
TGGTCTTIGCT
AAACTTI'AAT
GTTTGATAAA
ATACTTGCAA
TTCAATTCAA
TGAGAATGAT
CATGCAATTA
TCAAGATAGT
TCCTAGAGAG
CCACGATCAC
TAATTTCATG
TATCTATGTC
GAAA'TTIA
CCCCTTTTrIA
AGGCTCTGTA
CGCTI'TGGAC
AAAACACCGA
AT1TGTATIWTG
TTCAGGGCTT
AGACAATCAC
AACGAGCGAA
ACTCTCAGAC
AAACAAATAC
GTATGGCGGA
AjPGATTGCA 960 1020 1080 1.140 1200 1260 1320 1380 1440 1500 1560 1620 1680 1740 1800 1860 1920 1980 2040 2100 2160 2220 2280 2340 2400 2460 2520 2580 2640 2700 2760 2784 INFORMATION FOR SEQ ID NO:1431: SEQUENCE CHARACTERISTICS: LENGTH: 873 base pairs.
TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genozuic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .873 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1431 CAAGCAITGG GTATCAATAT TTTATITTAA GCTTGTGCGC ACGACTGAAG AAAACACCCC ACTCTAGAGC TTAAAGAAGA GAAGAAATCC ATAAGAAAAA AATGAATCCA TCPI'ATTCCA ATCCTLTGGCG ATATAGGGAT ATTCAAGCI' CTCCCTTGCT
GTGITCTAAA
TGAAGAAAAT
TAAAGACGCT
AAATGAAGTG
ACCCCAGCTT
ACAAATGGCT
TAACGCTAAT
GTATGGTA
AAAATAAGAA
ATCACCAAAG
CCCATTICTT
GCAAAAAAGA
TACATGCTCA
AAAAATAAGA
CCTTATGAGA
AGGAGCGGGT
ATCTCATTTT
AA.AACATGAC
TGGAAGAAAA
TTGATGAAAA
AAGGGGAAT
GCGGCTT'
AGT'rTGAACT
ATCAAAAGTA
ATGCTTTGGT
TGAAACGAAC
ACGCGCCCAA
AAGCCTGCT1
GCATGAAAAG
TATAGGCGTG
TTAAGCAAT
?TTTCGCTAAC
PCTUS 96/0912 IPENUs 18 DEC 1996 1005
GGGATTAGCG
AGCGATTC T
CCTATI'GACA
AATGGGATGT
TTGGTGTTAA
CTAAAAATGC
AATATTITATT
'CCTTACGCTr
TAGCTTCTI'A
AAGAAAAAAG
ATCAAAKJ7IT ATI-rAGGGGT
CTCCCTI'AAA
ATATTAG ETA
TTATGGGGAA
TCAAACCGCA
GTTTGCGTTA
AAAAGAGATT
GAGCATGACG
AGAAACTI'CG
CAACTAFI'TA
TATI'TAGGGG
AGCTTGAATA,
GGGATAIT'G
AGAGGGTATT
CTCAACCTCA
CAA.ACC'TT
TTG
GGGCGATGAA
TTIGATCTG'TT
GAGGCGTGG
CACAGCCTAA
AACACCGCTT
TATATTATIT
AGGGTrrAAA
GATGGATAAG
AGTGGGGTGG
CGCCTIGGG
TGAATrAGCC
TAAAAGCACT
540 600 660 720 780 840 873 INFORMATION FOR SEQ ID NO:1432: ()SEQUENCE CHARACTERISTICS: LENGTH: 678 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1. .678 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1432
AGATTTTTTA
TCTTTTAACT
GATTTTTTAT
TTAGGGCTII'
AACGCT T
TTAAACGCCT
GCTCAAAAAG
AAAT1'CCCTA
ATCCACAGGC
CGTAAGAAT
ATGGTAACGC
GCCCTTAAAC
GAAkAGCATAG
ACCACAATCG
GCG LTITAGG
TAAAACCCAG
TACGCCAAAA
TACAAAACAT
AAGCCAAAGC
ATGAATTGAG
CAGAACTCAT
TACAGGATCT
ATGATGAAAA
AAGAGCAG
GGTTATAAGC
CGCTATT TI
GGAGAGCGGG
TCTGGGGAGC
AATAGGCTAT
GACTIw1T1'GC
CTI'AGCGTTA
TGGGGGGCAA
TTTATTAGAT
CATCAAAGAA.
CGAGGCGCAA
ATGAAAGAAA
AAGGATTA
AGCGGTAAAA
GTI'AAAATCT
ATCGCTCAGG
CTTAAMTTAC
AAAATGGGGT
GCCCAAAGAG
GAGCCT1TrA
ATACACCAAA
AAGTTAGCCA
TCGTI'ACAAT
ATTT1AAGCAT
GCACGCTITT
TI'AATGAGAC
GCAAT1'CCT
AAGGCATAAA
TAGACGAGAG
TGGGCAflAT
GCGCTTTAGA
ATITCTGCGC
CAAAAACCCT
AGAGAATGTG
TCAAGAAGGG
AGGCTTGATT
CCTI'CAAAC
ATTCCCTCAT
CAAACAAGCC
CCTTATGGAT
TAGGGGGATI'
TAG'TrGAAT TACT1'TCAT1'
AGAAATCAAA
120 180 240 300 360 420 480 540 600 660 678 INFORMATION FOR SEQ ID NO:1433: SEQUENCE CHARACTERISTICS: LENGTH: 1782 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature POUS 96/0912.2 IPENUJS 1IbDEC 1996 1006 LB) LOCATION 1 1782 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1433
ATGGCTGATT
T=rATAAAA
AAAAGCTATT
GTCCAAATGA
GACGCTIGA
TTAAGAGACG
CCTTTAATCA
AGCGGGGCTA
AATI'GCATCA
TGCGAGGATA
AI'TGAAAATA
AACTTGCG ET
GCCCCTTTCA
CGTGGGAACA
TCAGCGTITG
GCCATTATCA
GCFI'GTTCTA
AAAATCGCTC
AAAAACGCTC
GAAGCGCGAT
AGCCACCATI'
CAAAAAGACT
GAATTGCTCA
ATAGATGGAG
TTTGTAGAAG
GGGGGTGCTA
AAACGCTTGC
CATAGATCCA
GGAGAAGCCA
GCGAGCGATC
TATTGTCCAG
ACCGCCAAI'
?TTTCTGTCCG
TGGTCAAACA
T~TI'GGAAAA
ATAAAACTTA
CACGAAAAAT
AGGATATI'?T
AGGATAAAAA
AA.ATCACTAA
AAGACAGGCT
TTGAAGAAGC
CTI'GCATGGA
ACAAGGCGGT
AAAAAATCCA
ATCATTACCA
ATGAA.ACGCT
TTAGCATTCC
AAGAGATTT
CGCTCTTCAA
CAAACAGCCA
CTTATCGGCG
CCAGAAGGGC
GGAGGGCGCA
TGATCGCTAT
AAGACATTAT
AGTGGGTGCA
CTAAACTTAA
GCGTGAAAAA
AGGAAAAAAA
TGAAAAAC
ACTCTACATC
TAATAATGAA
GATCGCTTT
TTCTTTGATC
CCC'rrATATT CTrAAAACAG
GGACAGCTG
GGCATGCATG
AGAAGAATAT
CATCAAAGAG
CTT-AATTTAT
TTTAGCCAAA
GTTAGTGAAA
CTCTCTCAAC
ATCGCATTIG
TAAAGAATG
TAAAAAGGGT
TAGCCAAGAA
TTTAGAGTGC
ATGCGTGGGG
CTACCATCTA
'TTAGACT
ATI'AAACATC
TTCTAAAGAA
CCATACGAT
AAAATITGCGC
AAACATGAAA
A'ITGTTGGAT
CGCCGTIA
CTCTAGTA
GGTAAGGCGA
ATCACGCCCA
TAGAAACCA
AAGCAGCTCA
TACATGGATT
CCTGGCGT1'A
TATGAATI'GC
TTTTATCAAA
TTAAAAATCG
CTTIGAATTGA
AGGGATAGGA.
CTCTACGAT
ATGTTCATGC
GGGTTTGACA
CCrTTGATGC CAAGAGTfl'A
GATAAGCTCG
AAAACCTCTA
GTGCCTTATA
GGAATGGTCG
AAAGGCTCTA
GCTAAAGAGC
GCTTAGAAA
AAAAGGGAT
AGTCATACTI'
GATGAAAGCC
CAAATCGCTC
TATT TTGGGA
AAAAAACGAA
GTAGTGGGGT
AAAATrrAAA
ATCCTCGCAC
'ITTTAGTGGA
AGCCTAAATA
'TTCTATTGA
AATATITTTGG
TCCCTI GGT TAGAGCGTrG
CTAAAGAATG
AAATGGAGCG
TGGATATT
GTGGGGGTAA
CTIGATGAAGC
CTGAACAAAT
TCTCTCACCA
CTTAATAGA
ATGAAGATCG
GGGTAGAAAT
TGTATGAAAA
ACGAATATGA
CACCGCCTAA
TITTAAAAAG
CTAAGGCTI'A
ITAAAT1'GCT
ACCGGTATGC
TTTTAAAAGA
GTITTGAAGC
AA
GTATCAATAT
AAAGCGCATC
AAGCTTACGC
AAACGAGCAA
CAACArI'C'r
TTTCCCTATC
CCCTTTTACG
TCAAAAGAAA
TAAAGCCCCA
ITTTAGAAATG
CC'rrTCTAGT
CCAAAAAATC
TGCTI'TAT
AATCA-TII'CT
GATGAAACAA
CTTA'FTGAGC
ATATI'CTAAA
AATCGCTATG
GATCTTAGAA
C'ITTGACACA
CAATGCATT
TCAAATGAGC
Tr1'GTGGGTG
CAGCGGGAGT
TCGTTCTAAA
CCCTAGCGAC
GATAAACTTC
AAAGGGCATA
GATAGAAAAA
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1140 1200 1260 1320 1380 1440 1500 1560 1620 1680 1740 1782 INFORMATION FOR SEQ ID NO:1434: SEQUENCE CHARACTERISTICS: LENGTH: 1272 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc.-feature LOCATION .1272 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1434
AGGAAAAACA
ACGGTCGCTA
ATTAAAATI'A
ATCAGTGATG
ATGGGTGGGG
TTCGTTACAG
TGAAAAAAAG
AAATCTTACA
AAAAAGCGGT
ATTrAGAAAG
TGGAAGCGCC
CCAATAAAGC
ATTGAATATA
AGAAAATCAA
GGTGCGAGAC
CGTGATAGAA
rI'ATCTrTA
CATGTTAGCG
GGGCTITG
GAAATCATI'A
GTGAAAAAAC
GATAAAGGGA
GCTAAAAAAA
TACCACCGCT
GTTI'AGGGTG
AAGACAGAGC
ACAAGGGCTA
TrGATATTGT C'T1'AGCCAA.
ATGAATTAGA
CGTGGGGAC
CGGCGTGGAA
TGCTI'GAA
CGTGGAGC?1'
ACAAAAACCC
ACAAATCGCT
POi/US 96/0912.2 WFENUS ib DEC 1996 1007
AAAAACACCC
TTAAAAGACG
AGcAATTACA
GACGCGCAGC
GCGGCGCACA
CAAATCT1A TITrGG TATA
AGGGTGCATC
AACGCTATCA
GGAGGAGAC
AGCTCTCTAA
ATCCAATGCG
ATCAGCGCGA
CCGCAATCCA
CTGAACGCCC
CGI'TGGAAA
CCATAGGCTT
GCTTGAGCGC
?r'rrAAGCCA
ATTTAGGCTA
AATI'ATTGAT
TTGAAGGCAT
GCATCAAACT
CAAGCATGAT
GCGTCATAGG
CTACCGCAAG
TGCTGGGCTT
CTTACTAGC
TTTTAGCCCA
ACAAGGCTAA
TTAAAGAGCT
AT
TGAAGCGAGC
TAATCACATC
GATGTAAA
TGCGGAATTG
TI AGCGTCT
TGAAAAGATA
TTrAGGCATC
TAAAAATGAA
GGATAAGGG
CGCGGTCAI'
TGAAACCCCT
GCGC7GTA
AAATGATATT
AATCTTATTr
TGAAAATTTA
GTGTGTGGGG
CTTCTTTTA
AATCAAGCGA
AACCCTGAAT
?I'AGCGTATIG
GAGCCAGATG
GCTAAAAMAC
TGCATGCTCT
CGCGAGACTI'
AGCGATATI'A
CAAAAACTCC
GTGAGCGATG
TCGCTCAACA
TCCACGCACA
CAAAGCGTGT
GTATCCCCAT
AAGGGATT
GCTITAAGGA
'ITGACATI'AA
GCATTGATGC
ACATGGAATI'
ACCAGGATTIG
CTAAAGTGGA
TGTATTATGG,
TAGAAATCGC
CCCTAAAACC
AAAAAGGGGT
ATGTCTTGCA
CCACCAACGA
TGGATACCCC
TATCAAGGCT
AAACGGCACG
CGCTTTGAAA
GGGCATTGAT
GAAATTAGAA
TG3CAAAAGAG
CATTGAATTA
TGGGGTGAI
GGCTGGGGCT
AAGGAAA1AA
CAAAGAAGAA
TTTTTCTCAA
AAAAGAAATC
AA.AATCTATG
TAAAATGATC
420 480 540 600 660 720 780 840 900 960 1020 1080 1140 1200 1260 1272 INFORMATION FOR SEQ ID NO:1435: SEQUENCE CHARACTERISTICS: LENGTH: 978 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .978 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1435 AGTCGCTF1'A
ATI'ATIGGAG
AAAAACGCCG
ATTGAAAATrr
CAGGAGCAAT
AAAAAAGGTT
GTGATCATCG
TCGGGTAAAG
GTAGCGGTGC
TGCAAAAAAG
GAGCATGCTA
AAGGGCGATG
AGAGAATTAG
TITGAAGCAAG
GATFTTCCA
GCCCCCAAGC
AAAGAGCAAT
GTGGTCCTGC
T?1'TATTTIGA
ATCCGGGCGT
GCTTTCGCTT
CTCATTTTGT
CTACCGGTGG
GCGTTAGCAC
TTGGTGGAGG
TCTATCTCAT
AAAACAATAG
CTI'CTGGCGT
TCGTG3CCGGG
AAGATAACTC
TGAAGACGAA
AAGTGGTTTG
TGAACAAGCT
AGGTTTGAGT
AAAAGGAATG
TAAGGAAGTG
TGG ITrAAAG
TATTTITGGCA
TAGCCCTAAA
TrI2TGCAACA
CGATACCGCC
CCACAGAAGA
*TAAGATTGAG
GTCTTICTT1TA GCTTTTrATT
CATGCTATGC
TGT'rCAGGGC
TGCGGCAAGC
?I'TAGGCTAG
GCGGGGCTT
CCTGGGGGGC
GTGAGCGGAT
CATGAGATGA
GAAGATGGCA
CGCACAGGTA
TGCGATGGCT
GTAGAAGAGG
GATGGTITrA
TTTTT'AACCC
AGCATTAAAA
TTTGTGGG'rr
GAATGCGATG
TGrl-GCGG
GATGGTGCTA
TGGCCATGAT
ATGCCACTAG
AAATCACTGG
TGGATTTCAT
CCGCCATTCA
AGACTTTTGA
TCAAGGGCGA
TCTTTTACAA
CGATTTATCT
GGTGTGCGCC
CTTATGTGGT
ACACAGCCAC
ATGATGTGAA
AATACGGCTC
CAGGAGATAT
CGGCAGCCTT
AGATTGCGCG,
AGGCGGTGTT
CAGTAGTGAG
GCAACCATGG
AAGGGTTTCT
AGCTAAGAGC
GTCAGAATAT
AAATAAGGAA
AGCCAATATC
TATCACTTTA
GGAAGAAATC
TAACGAAAAA
TAACGCCGTG
TAVI GTCGTG TCGCATrrI'T
AAGCGTGATT'
120 180 240 300 360 420 480 540 600 660 720 780 840 90.0 960 978 TCTTATTTAG AACAC CAT INFORMATION FOR SEQ ID NO:1436: SEQUENCE CHARACTERISTICS: LENGTH: 837 base pairs TYPE: nucleic acid MA..sa POT/US 96/091a2 IPENS DEC1996 1.008 STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: rnisc.feature LOCATION 2...837 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:l436
AAATI'ATGGG
AAAT TGGTT
CACCAAGCGC
CTAGTTAAAA
GCAACCAGTC
TTTATGAGCT
AT -AGCTCA AAA. AGGGCT
CATTTATTGT
CAAGAGCGTG
ATCACGCCCA
GATACGATAA
GTGATCGCTG
AAAATCGCTC
AGTT'AGC'rr
TGGTI'AG
A).ATrTTTGA
AGCATI'ACA
TCATCAGTGA
TGGGGGAGCT
ATGAAGCGAT
TGGATTTr
ATGATGCCAG
TGGGGATCAT
AGATTGCCAA
TGGACGCTAC
ATGATGAGCA
TAATGAGAGA
GCGTGTTI
AGACACCACA
TGCGkTI'AT CCCTAITTrC GGT ETCTAAG
TGGGTGCTAT
CTGTMTI'A
AGAAAAACAC
CGTGAAAAGT
TAAAGCTTAT
AGIEITIwrG rTTATCCAT
AATCTCTACG
ACTCCATTr ATCA TTCT ACTrTTACTCA
TCCAAGACTI
ATCACGCAAA
TITTATACG
GCGAGCCATI'
GAAGACGATA
ATCCAAGAGT
GAGCCI'TAA
AGCCATGGGG
AAACACAGCC
GGCGTGAAAA
ATAGCGCGAA
AAATTTTGA
TAAATCAAAA
ATAATATCAA
TTGAAGGCGG
ATATCAAAGA
CTTTAAAATA
ATrCGTTGTG
TAACCI'GAA
TAGGCTATGC
ACCATGAAAA
TGGGGACGCA
GAAAATGGGT
ATCTGGTGTr
AAGAAGAACC
AATGGTGGCA
AGTGTGCGAT
CCCCACCCAC
GTTGCACCCC
CATGGGGA?1'
CCATGCGAAA
GCAAAAATGC
AGAGGATTIT
GCGTI'GATG
CCAAGAGATA
AGGCTATGTG
TGT'rCCTGTG
ACAACCT='
CTATAGCCCT
GTTTGTA
INFORMATION FOR SEQ ID NO:1437: SEQUENCE CHARACTERISTICS: LENGTH: 708 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc..feature LOCATION .708 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1437
GGGATTITA
AATATACAAG
GCTGGAAAAT
GCACAAAACA
GTTGTCTCTA
TATCAATTT
ACCTACGAAC
CATCACCCAC
TAXITTCTAA
ATITCATI'
CAACGCTTAT
ATAATATTCC
ACCTATTCAA
TCACAAAAA
ACCTAAGCGA
AATTAGTTAT
CATCAGCATA
TAAAAATCAT
CAACACTATT
ATACCACOAC
CTACCCACCT
CTGCACTCTA
CGGACAAAAA
TATGGATGAA
CACCCAAAAA.
ACTAGTACAG
CTAGGCATTA
AATGTTATAC
GGATTAAACG
GATTTGTTTG
CAGCGCT'IAA
CCAGAAACCA
CCATGTITAA.
CCAT'rATTGG
GATCAGACTA
CACAACGCAA
CAAACGACCT
AAAAAAATCT
AAATTIGACT
GTI'TAGAGCA
AAACGCTTITA
CACAAATGGT
TAATTTTAAA
GCAATTGGGA
TTTrAAATl'C
'ITTAAATAAA
AGCTCTTAGC
AAACGCTCT
US 96/09122 1WIS -10ULLU I96 1009 ATAAGACTAT CAAATCTCAT AAGCTI'GCGC AACACCCAAC ACTCATGATC CTATI'GTCrr AGATAGTTGC GAATGGGTAT ATTGCTCAAT ACAAACCTTI' AAATTCTATA ?I'AAAATCTG AAAGAAAAAC CAACCACAAA AGACI'A'TA GCGTTAC'rAA
AACTTACAAG
TGCTCCTTAA
TAGCTAAXA.c
AGGATATT
TATCATCGCC
GAATGGCAAC
'TITAACTT'r INFORMATION FOR SEQ ID NO:1438: SEQUENCE CHARACTERISTICS: LENGTH: 339 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .339 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1438
-ATTI'ATICTC
GATCI'ITITA
GGGGTTTTTG
AI~ATCAG
GGCTATGT
ATCGCTAAAA
ATCTCGCTCC
TAACTIGTCA
TATCTAACGG
GGAGTTTAAC
T'IGGGAGCTT
TCAGTIT1AA
CATI'ATGCAC
TGTGTTAAGG
CTI'GGCTCGT
CCCACACCAA
TTTAATCCAA
ATTAATCACT
TATCAAMTAA
ATCAAAATGC
TTTGGCTATG
AGCI'rCCAAC
TTTAAGCC
TI'GAGTTF1 9 CAAGT1'TCAA
GCGTGTTTGT
TGGTTTTAAT
TGGGTATTGC
CG?1'AATGTC
TATAATACAA
TGCTTTI'A
tCCCTACTC
GGTGCTAATG
A ITAGAAAGC INFORMATION FOR SEQ ID NO:1439: SEQUENCE CHARACTERISTICS: LENGTH: 240 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: No (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc feature LOCATION 1...240 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1439 AGTATGGGCG GATTCACAAG CATATGGCAT TGGGTCAITG TITI'A'TAGT TI'ATTTGGGG CTAAAAAGAT CCCAGAATTG GCTAAAGGTT' TAGGCAGTGG TTCAAAAAAG CCGTGAAAGA CGATGAAGAA GAGGCTAAAA ACGAGCTAAA GCTCAAGCAA CACAAACCAA AGTGCATGAA ACTAGCGAAA TI'AAAAGCAA
GATTGTGTI'G
GAT'IAAGA.AT
AACCCTAGAC
ACAAGAAAGT
PCT/U1S 96/09122 1010 IPEMS 16 r_0 996 INFORMATION FOR SEQ ID NO:1440: SEQUENCE CHARACTERISTICS: LENGTH: 801 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .801 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1440
AGAAAAACCA
TTATCTATI
ACTITTATTT
ACTGAAATT
GCGATCTIG
TACATGCTAT
ATCGTTIGTA.A
ATCACTATC
TrGTTTTrGr TrAGGAII'
TTAGAATACC
AATCAACT1'C
ACATTTI'CA
ACACCAAAAG
ACCACAAAAG
TAAAACTTGA
ATCCTATITI'
'TI'ACT"1AA
GTCTCACACA
CACCAGCAAC
TCCTATAT1GC TrAAT TAA
TTTGCTTGGC
GTAATATCAT
TACCTAATAT
TAATCAAAGC
TTATTGGTGG
AACGCATGCG
ACTTATTAGC
AATCAAATCT
AATGCTCCTA
TAACATTATA
AGCTATAACA
TTTCAA.ACAA
TTTTATCITTT
AGCGCTTATT
AA'TTrGTA
CAATCTCTAT
TGGTCAATI'A
TTTTCAAGGG
CATTATTA
GTTIACTAAAG
TATCTCACCA
TI'ACTAATI'
GGTCTAATGG
AGCTCTAGAT
ATAACTCTAG
ATTGTTCTCT
TTGGGGTTrA
GCTAGAATIT
GCGCTAATGT
~TTTATCAAAA
ATTGATACTA
TITI'TACTA.A
GATATTTIAAT
ATACAAGCGC
TTGTTTTTC
GACTI'CTTAT
CGCATAATAT
CAI'AATCGC
CTTITATGC
TI'AGCA'TT
'ITCAAAACGA
CTI'GTAATOGT
CATCTATTT
TACTGGTI171
GCGCTA.ATCG
GGGTGCAAI'
GCTATITGG
AAAAAATACC
TATT1'CTAGC
ATI'CTTATI'C
TTCAAGACTA
GGvTCAATATC
TI'CAAGCGCA
ACAAAGCATC
TTTGTCCT
TTACTACCTI'
AGCAACITCA
CATGI!ACTA
120 180 240 300 360 420 480 540 600 660 720 780 801.
INFORMATION FOR SEQ ID NO:1441: SEQUENCE CHARACTERISTICS: LENGTH: 816 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .816 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1441 AGAAAACAAG AAATGAAAAA ACI'CTTI'A CTCTIAG.AGC ATAAGATCGT AAAAATGGC 71'AATTATI'G TGATTGTGTIT AGTGGGTTI' TTTCTrrITI' ATGAACAAGA AATCAAAGAA PCT/J S 96/09 12a 'PEAUS I DEC'j996 1011
AAAGCTGITA
GAAGGCATI'A
AGCGTTAATG
CAAAAGTTAC
'TTrCAACT CGTATrAGCA
ATAAAATCCA
GG'FrCTrT
TCAAGGGGAA
TCGCTAITI
ATAGGATTAA
TCGCI'GAGT
ATGTTTICTCA
AGAATAAAAT
AGAATATAGA
CAAATTTGCC
ACAATACCG-C
GCCAAAAAGA
AAGAAAAACG
CCTITGCTTTC
TAGGATI'GGA
CCTTATTATC
TCTl"PTGTI'I
TTTCATCT
AGGTAAATI'C
AGATACTATC
AAAAACACAA
TAAGGACTTT
TAACGAAGAT
AACGCAACCT
AGAACTTGAA
CAGTTCTTCT
I'TGTGAGAAG
TTCATTGTT
TTCTAAGTTT
GTCAAGGCTA
CCCACTITCAT
AATCAAGTIGA
AAAGATrAG
AATAAAACAC
GA.AAAAAACC
CCCA7T'ITCTA
AAAGAATGGG
TCTIrCTT
CTCAAATCCT
TGCCATCCAC
TCTAGAGAGC
GGATCA
CI'ATITGITT
AGCCAAACGA
ATGATITI'AA
TTATAAACc GCCTGGT GAT
TAAAAAATAG
CAAAACCTAG
CI'ITTGAAGT
ITTTAAAAGc ITCTCTTr
TAGTIGAATGC
TCAAGCTTAC
TGAAACTAAA
TGCGCTAGTG
ACAAAGTCCA
TFI'AGCGTCT
CGTTCTCAC
TGTITC TT
TTCTTITA
TTTCAAGT
TTIGCTCTCTA
GTCTAACAAT
180 240 300 360 420 480 540 600 660 720 780 816 INFORMATION FOR SEQ ID NO:1442: SEQUENCE CHARACTERISTICS: LENGTH: 1014 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE:. NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1 1014 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1442
AAAATCTTCA
TT GCCTAAGA
GI'AAGGCTA
GAGCAACA)A
AAAAAGCGTIG
CTITTTCAAG
GCTCTAGCCC
CC'ITATTI'AG
AAGAGCATCC
AGAGAA.AATA
CAAAGCGCAT
TACACTAATA
ACCCAAGCCA
AAGCGTTATA
G 1TCCCCTAA
TTAAAAGATT
CATGTCGAGA
AAAAGGCTr1' T TI'AGAAGA
AAGCAATAAA
AGACACAAAG
ATATGTI'ACA
CAGAGCGTAA
TATAGAAGC
TAACCTI'r
GTGCTAATCA
TI'TCAAGTAT
TT'GAAGTG3TG
TAAATCTAAC
ATATI GAAAT
GAATAAITAT
ACCCTACAGG
TAGATGAGAA
AAAAAGACCC
AAGGCATAAA
AAGATITAA)).
CGAAGAAGAG
AGAAAAAACA
AAGCACTATG
AATrGGCGAT
CATTA'ITATT
AAACGCTACA
AGCGCTrGTG
AAAAGAGCAA
GGAT7IT
ACGAAAAATT
ATCCGCACAA
GACCTTTGA).
CTTATTGT
AAATAAAGTC
TCATATGAGC
ATIGGAAAAAG
GAAAAATATG
C'rrGAAGAAC
CTCAATGGAT
TTATI'TGATG
TGGATrrA
GTATGCTTAT
CAAAATTTG
AGACAAT1'GG
AACGAAATAG
GAAAAACTGG
AGCATTATCA
CTITTTCATA
T1TTGAACCTA
ACAGGTTATG
AAAGATGATG
CAGTATAAAG
TTTGCGTGAG
GCGATGATTG
AAGTCAAAGC
ITTTAAAAAA
AAGTCAAAGA
GCAGTGCGGT
TGCCGTTAAA
CCATAGTCCA
TAGCGTCTTA
CCCACGAAAC
T1TTrTATGA ATATCGCTITr
AAGAAAAG'T
TITGAAATITGA
ATGTAACTGA
GTGTGAAATC
ATGTTAAGGA
CGCATGGGGG
GGAAAAACAT
TAAAGCCAAA
AGTTGGTTTA
AGCTGATGTG
AGAAAAAGTG
AAGAGCAGAC
TGTTAATA.AT
CAT1'AGGTTG
GCATAGCATT
AATCAGTAAA
AGAAAGCGAA
TACAAAATCT
AATI'GCGATT
TAGGATTATC
GCAA
120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1014 INFORMATION FOR SEQ ID NO:1443: SEQUENCE CHARACTERISTICS: LENGTH: 930 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) AM~s~e .2 ~i~T PU/US 96/09122 IPENUJS 16 DEC 1996 1012 (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: No (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .930 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1443
GTI'GTGGTAA
AG'FrATCTTG
AAAACGCTGT
GCTATIGTTIG
AAACTCTTAT
TTAATCCI'A
AI'ATCACTG
TCAAGCATTG
ATI'GAAATCT
CGCTTGCATG
ATCAATAGCA
AGCGATAI'G
GATAAAAACA
ACCATTAGGG
GAACGCATCA
ATT'TCTATCA
TAAGGTTAGT
TCTCTGTTA.G
TAGTGGATT
TCITTTGTAT
CCAAAAAGGA
TCATTACTAC
TTTTAGGAAC
CTGGAGGGAT
CTGGCCTAGA
ACGGGCGCI'
ATAACACTGC
AACTGGTIGCA
TGCCCACI'T
TITGGGCAAA
AAAACGCCCT
ACAAACAAGA
CCTA.AACATG
CGAI'q=TG
?TCCCGCAG
AGGTTTTAT
TGAGATI'G
AATCATCGCG
GGTGGGGATT
AATCCTTAIT
GGGCAAAGTA
GGCGGTTTTG
GTGTCGGCGC
TAAGACTATA
CATTGGAATC
GATI'GAAGAC
GGACGCTAAT
CTCTTCTA.AG
CTAACATGTC
ATTrGCAAGG
GCAAAGCATI'
TITTTCGTT
GCGAATITTTG
CTCAGCACGC
GCGGTGGCGT
AT1'TrACACC
GAAGCGCT'A
CCTAATAGAA
ATTGAATGGG
AAAGATGT~rA
ACGGTIT
GGGATCTTTA
CGTATI'GAAA
AAATI'AGCTA
AAAGA TrAT
?I'GGGATAAT
TCI'ACGGAAk
TCGCGCAGGT
TAGGCGTCCA
TGGCTITAAA.
CTTITCAAAAA
ATTTrTAA
GTGTCGCTAA
TCTGTGGGGT
TIGACGGGAT
GACAAAGTTC
ATGTGAGGAG
TCCCITTCAA
TATAAGGATA
GGATGAAAT1'
CTTAATCAAG
CAAAACCATG
TACTTTTATC
AACCACCTCT
AGATTATCTI'
AGGAGACATC
TACTTCI'TA
?I'CTAATAI'
AGGGTATGGG
GGAAAAAAI'
GCTGAACT'C
CGAACTCAT'
CAAGCTAGAT
INFORMATION FOR SEQ ID NO:l444:.
SEQUENCE CHARACTERISTICS: LENGTH: 477 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION1.. .477 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1444
AGCAAAAGAA
CATCCTATAA
ACAC'TrGCA
AAGAGTGA
TTAATAGAAT
ATGAGAGCCA
ATTGATTTAA
GAAAAATCCT
CACAACAAAC
TGTTI'GCCTA
TGGCG'rITCA
TAGGCAACCT
GTGGCGTCCC
GACAAGTGCT
AAAAGATG
CAATGATCTT
CTOI"I=ICTA
TATCGCTAAC
AAAAATATCT
TITCTCAAGTG
A'rrAAGCGAT
AGTAAAAAAT
CAAGAACTAC
AAAAAAGCAA
TTCATTGATG
GCGCTCGCTC
CAAGTCAAAG
ATI'ATCTACC
AGTGAAATCA
ATCG'ITACAA
ITIATA'ITCT
ACCAAGAAAC
AAACTAAAGA
AAGCTAGAAA
AATTAGGCAT
CCACAAAAGA
ATT'TC "rACA
ACGCTTCAGC
TGATAGCAAT
TTATAAGGAA
CTACATTATG
GATCAACGGA
TGATAAAGCA
TACTGATGAA
CAACACGGAC
TITTATTGAA
GCTGGTAATA
GAGTAI'
P I /091? I PENIS 0uE C 1996 1013 INFORMATION FOR SEQ ID NO:1445: SEQUENCE CHARACTERISTICS: LENGTH: 774 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .774 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:144S
CTCCTTAAAA
ATGGATTTTA
TTGGTTrI'AC
AACCCGCAAC
GTTGAAGAGT
CAAATCAATA
TrI'GAAAAAC
GAGATAAALAG
ACTAAAAGAT
GAAATTGAAA
ATCCAATTGA
GTTAAAGAAT
GGATTGGTAA
ATATTGATGA
AAAAATGCCC
TTATTGAAAT
CGAATTTA TT
CAGACAAGGC
AAGCAAGCAT
GAGTCTATAA
AAAGTI'CTCG
ACGATCTGAT
TTCTAACCCA
CCCACCATAA
ACGACCATCT
GAGAAATAAT
GAAAAAGCTT
TAATTI'TGAA
CCACTCTAAA
TAGCATCTI'A
CAATAAAATA
GATTTCTAGA
GGATA.ATAGT
TG'ITTATGAA
TGATAGAAAT
CACAAACAGC
TGAAACGCAT
TAAAGATA?1'
CCCCAGTAI'
TCCGTAAGTA
AA)AAAATGTG
GGACTACACA
GATAAGGGCG
CAAGAGCCAC
GATCCTAT'G
AAAGAAGATG
GCGAATAAAG
ATTGATAGAA
T1'AAAAGAAT
AAGAAAGCCT
TACCAAGAAG
TCTAGCGCTG
AGGTAAATGA
CGTTTCTTG
TGCAAAAAAA
ATGTGCAAC
TCCCTTATGT
AATGGGCAAA
TCAATITTCTI'
AAGGGTTI'GA
ATAGAGAAT
TGAAAGAGCA
TAGAAAATGG
TAGAAAGAAC
AGTATITTCAC
AAAAAGGCAC
T'ITCTCAAAT
GAAACCCAAG
AAACAATCCT
CGTGAAAACG
GTATrTAAGC
TGCCAATGGT
AAGGCGCATC
TIATAAAA
AGGGI'AGAA
CAATGAAATC
AAAAGATGGT
CCTT
INFORMATION FOR SEQ ID NO:1446: SEQUENCE CHARACTERISTICS: LENGTH: 274 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .274 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1446 Asp Ala Ang Sen Phe Phe Leu Arg Leu Val Ala Met 10 Ala Leu Cys Leu Ile Leu Ile Asn Ser Arg Gly Val Ala Met Gly Tyr Ala Sen Lys Leu 25 Ala Leu Lys Ile Cys Leu Val Gly Leu Cys Leu Phe Sen Thr Leu Gly 40 Asp Glu His Leu Glu Gln Lys Gly Asn Tyr Ile Tyr Lys Gly Glu Glu US 9 j/09 1 ?22 18 DEC 1996 1014 55 Ala Tyr Asn Asn Lys Glu Tyr Glu Arg Ala Ala Ser Phe Tyr Lys Ser 70 75 Ala Ile Lys Asn Gly Glu Ser Leu Ala Tyr Ile Leu Leu Gly Ile Met 90 Tyr Glu Asn Gly Arg Gly Val Pro Lys Asp Tyr Lys Lys Ala Val Glu 100 105 110 Tyr Phe Gln Lys Ala Val Asp Asn Asp Ile Pro Arg Gly Tyr Asn Asn 115 120 125 Leu Gly Val Met Tyr Lys Glu Gly Lys Gly Val Pro Lys Asp Glu Lys 130 135 140 Lys Ala Val Glu Tyr Phe Arg Ile Ala Thr Glu Lys Gly Tyr Thr Asn 145 150 155 160 Ala Tyr Ile Asn Leu Gly Ile Met Tyr Met Giu Gly Arg Gly Val Pro 165 170 175 Ser Asn Tyr Ala Lys Ala Thr Glu Cys Phe Arg Lys Ala Met His Lys 180 185 190 Gly Asn Val Glu Ala Tyr Ile Leu Leu Gly Asp Ile Tyr Tyr Ser Gly 195 200 205 Asn Asp Gln Leu Gly Ile Glu Pro Asp Lys Asp Lys Ala Val Val Tyr 210 215 220 Tyr Lys Met Ala Ala Asp Val Ser Ser Ser Arg Ala Tyr Glu Gly Leu 225 230 235 240 Ser Glu Pro Tyr Arg Tyr Gly Leu Gly Val Glu Lys Asp Lys Lys Lys 245 250 255 Ala Glu Glu Tyr Met Gln Lys Ala Cys Asp Phe Asp Ile Asp Lys Asn 260 265 270 Cys Lys INFORMATION FOR SEQ ID NO:1447: SEQUENCE CHARACTERISTICS: LENGTH: 149 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...149 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1447 Thr Met Lys Asn Thr Ser Ser Ser Thr Thr Leu Thr Met Asn Asp Thr 1 5 10 lie Ala Ala Ile Ala Thr Pro Leu Gly Lys Gly Ala Ile Ser Ile Ile 25 Lys Ile Ser Gly His Asn Ala Leu Asn Ile Leu Lys Gin Leu Thr Gin 40 Lys Gln Asp Phe Thr Pro Arg Tyr Ala Tyr Val Cys Asp Ile Phe Ser 55 Asp Gly Val Leu Leu Asp Lys Ala Leu Val Ile Tyr Phe Lys Ala Pro 70 75 Tyr Ser Phe Thr Gly Glu Asp Val Cys Glu Ile Gin Cys His Gly Ser 90 Pro Leu Leu Ala Gln Asn Ile Leu Gin Ala Cys Leu Asn Leu Gly Ala 100 105 110 PC >!92 101S I PENUS 16 DEC 1996 Arg Leu Ala Lys Ala Gly Glu Phe Ser Lys Lys Ala Phe Leu Asn His 115* 120 125 Lys Met Asp Leu Ser Glu Ile Glu Ala Ser Val Gin Leu Ile Leu Cys 130 135 140 Glu Asp Giu Ser Val 145 INFORMATION FOR SEQ ID NO:1448: SEQUENCE CHARACTERISTICS: LENGTH: 268 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc..feature LOCATION I1.. .268 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:i448 Asn Leu Ile Tyr Arg Ser Ser Gin Arg Ser Ala.Ala Arg Leu Lys Leu Val1 Asp Pro Gly Gin 145 Leu Thr Arg Arg Ala 225 Asn Tyr Leu Ile Lys G iu Ala Val1 His His 130 Ala Ile Giu Asp Met 210 Ala Leu Met As n As p Arg Pro Glu Ala Ala 115 Phe Arg Asn Val Asn 195 Gly Cys Val1 As n Lys Giu Arg Asp Ile Thr 100 Ile Arg Leu Giu Pro 180 Ala Arg Ala Ser Phe 260 Glu Met Asp Se r Thr Leu Asp Ala Trp Gly 165 Gly Val Gly Leu Giu 245 Asn Pro Ile Ala As n Giu Ser Glu Phe Val1 150 Tyr Cys Val Ala Leu 230 Lys Leu Met Ala Met 55 Ala Pro Giu Val1 Gly 135 Val Tyr Ser Phe Lys 215 Gly Leu Met Ile Ser 40 Gin Gin Ile Val1 Phe 120 G iu Pro Ala Leu Ser 200 Val Arg Glu Glu Glu 25 Gly Ala Tyr Leu Leu 105 Ile Ile Pro Ile Cys 185 Thr Tyr Ile Se r As n 265 10 Tyr Tyr Trp Ala Ala 90 Ala Gly Val Ser Phe 170 Met Ser Leu Pro Gin 250 Phe Leu Giu Val1 Ala 75 Cys Asp Ser Lys Lys 155 Gly Gly Thr Gly Thr 235 Lys Arg Lys Asp Asp Val1 Pro Thr Cys Asn 140 Met Ala Asn Arg Ser 220 Lys Asp Leu Ala Ser Lys Lys Ile Asn Thr Met 125 Ala Asp Ala Gin Asni 205 Ala Giu Lys Cys Val Asn Ile Giu Thr Pro Val Giu Ile Asp Pro Gly Lys 110 Thr Asn Pro Pro Giu Gin Gly Ala 175 Ala Arg 190 Phe Asp Glu Leu Glu Tyr Ile Tyr 255 Val1 Lys Leu Leu Asp Asp Arg Ile Ser Glu 160 Arg Val Asn Gly Met 240 Arg INFORMATION FOR SEQ ID NO:1449: AMErZ:o- iiE F EDITORIAL NOTE NUMBER 63278/96 THIS SPECIFICATION DOES NOT CONTAIN A PAGE 10 16 PC1i;U 96/ 0912.
IPENUS i EC 1996 His Asn 385 Asp Ser Asp 370 Thr Asn Phe 1017 Trp Val Asn Tyr Ser Ser Ala Ile Gly Leu Glu 375 380 Leu Asp Pro His Phe Lys Lys Ser Phe Gln Glu 390 395 Gin Val Arg Tyr His Asn Gln Ile Tyr Gln Ala 405 410 Glu Pro Ile Lys Asn Glu Ser Glu Thr Lys Lys 420 425 Met Phe Leu Ser Leu Glu 400 Leu Gly Tyr 415 Glu 430 INFORMATION FOR SEQ ID NO:1450: SEQUENCE CHARACTERISTICS: LENGTH: 486 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...486 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1450 Tyr Leu Asp Asn 1I Lys Ile Leu Lys Gin Ser Ser Val Gly Ile Val Asp Ile Gly Thr Leu 130 Tyr Leu 145 Asp Ser Asn Ser Gly Arg Phe Glu 210 Ser Ser 225 Tyr Ala lile His Pr6 Phe Asp Phe Pro Ser Phe Ser Val 115 Ile Ile Leu Tyr Tyr 195 Leu Phe Pro Ala Ala Tyr Gin Leu Lys Pro Asn 100 Gly Asp Gly Ile Leu 180 Leu Asp Gly Ile Ala 260 Tyr Tyr 5 Tyr Lys Leu Val Thr Leu Gly Gin Arg Glu 165 Phe Ser Tyr Arg Val 245 Gin Phe Leu Asn Thr Phe Ile Phe Asn Gly Phe Leu Arg Ala Leu Ala Gly 70 Ala Leu Ile Ala Trp 150 Ser Tyr Asn Lys Ala 230 Thr Leu Ser Ser Pro Phe 55 Phe Thr Pro Leu Thr 135 Trp Asp Ser Met Ile 215 Leu Glu Tyr Pro Gly Leu 40 Asp Asn Phe Lys Gly 120 His Gly Ala Tyr Asp 200 Asn Ala Asp Phe Lys Lys 25 Leu Tyr His Val Asn 105 Ala Gin Phe His Gly 185 Phe Ser Phe Gly Ser 265 Ile 10 Leu Phe Lys Ser Thr 90 Ile Leu Ile Leu Thr 170 Asp Met Lys Gly Arg 250 Ser Tyr Lys Val Phe Lys 75 Ala Glu Ala Tyr Gly 155 Arg Lys Ser Ile Gin 235 Lys Lys Gly Arg Ser Ser Leu Thr Lys Tyr Gly 140 Asn Asn Phe Ser Ala 220 Trp Glu His Ala Ile Ile Gly Asn Ile His Asp 125 Ser Ala Tyr His Tyr 205 Leu Ile Val Val Pro Gly Leu Val Ser Lys Ser 110 Ser Glu Pro Val Leu 190 Thr Lys Arg Tyr Gin 270 Gly Ala Tyr Ala Lys Leu Leu Thr Leu Trp Leu 175 Lys Gin Trp Asp Asp 255 Val Val Val Asn G1u Glu Gin Lys Lys Phe Lys 160 Tyr Leu Gly Phe Trp 240 Gly Met Lys A SHEET ft i.-*>oct 02/09 '99 THU 17:29 FAX 61 02 62853593 I.P AUSTRALIA 002 WO 96140893 [ICT/US96/091 22 1018 Ile Gin 305 Asp Leu Asn Phe 385 C ly Tyr Lys Val1 As n 465 Ser Asp Ile Trp Gin 340 As n Pro Ala Tyr Arg 420 Ser His Phe Phe Leu 300 Ala Trp Asn Ile 380 Gly Leu Leu Leu Leu 460 Ser Leu Arg Asp Leu Ala Ser 335 Gly Phe 350 Trp Ty c Gly Gly Va I Phe Arg Tyr 41.5 Leu Gly 430 Tyr 71yr Gly Pro Leu Met Ala 320 Leu Gly y Val1 Gly 400 Thr Tyr Val1 Phe Val1 480 INFORMATION FOR SEQ ID NO;14S1: Ci) SEQUENCE CHARACTERISTICS: LENGTH: 254 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc feature LOCATION .254 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1451 Val Val Thr Loeu Ser Ile in,- Lou Ala Glu Asn His Ala Gly Val Gly Lou Ala Lou Ser Arg Ph.
Ile Ala Ile Gly Met Lou Ile Asp Ser Ser 02 SEP '99 17:30 tnRTmr!SHEET (RU 61 02 62853593 PAGE, 002 .li 2 Ph.
Leu 145 Pro Ser Ala Gly Thr 225 Asp Val. His Ala Ser Leu Asp Ser Leu 180 Lys Lys 195 Asp Giu Ile Ser Leu Val Asn Leu Glu 165 Asp His Leu Ph.
Arg 245 Pro Lys 135 Ser Leu 150 Gly Asp Gin Ser Val Lys Gly Leu 215 Ile Pro 230 Lys Asn Lys Phe Val1 Lys Glu 200 Asp Lys His Val1 Pro Val1 Asp 185 Val1 Leu Lys Gly Ile Phe Leu 170 Leu Lys Gly Glu Phe 250 1019 Leu Gly 140 Val Gly 155 Ser Val Met Leu Ser Ile Gly Leu 220 Trp Ser 235 Phe Lys Phe Met 160 Pro Ser Thr Asp Lys 240 INFORMATION FOR SEQ ID NO:1452: SEQUENCE CHARACTERISTICS: LENGTH: 157 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .157 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1452 Trp Leu Phe Leu Thr Cys Tyr Gly Sen Val Ile Lys Lys Gly Tyr Ile 1 Arg Val1 Asn Gly Lys Lys Asn Ala Gin 145 Gly Ala Asp 5cr Asn Ser Asn Leu 130 Tyr Asp Lys Glu Ser His Ile 115 Ser Met Leu Sen Lys Thr Gly Lys 100 Ala Phe Asp Met Sen Ser Glu Leu Lys Glu Gly Gly Arg Ala Gly Thr 70 Glu Ser C ly Pro Gly 1S0 Ile Ph.
Lys 55 Lys Gly Asp Val1 Tyr 135 Leu Val1 Ala 40 Lys Asn Val1 Lys 5cr 120 Ph.
Met Asn Asp Tyr Lys Leu 90 Ph.
Pro Ang His Lou Lou Lys Lys 75 Glu Tyr Ile Thr Ile 155 Ph.
Glu Leu Lou Lys Lys Val Lys 140 Arg Lou Thr His Tyr Ser Gin Asn 125 Ser Phe Val Gly Lys Asp Pro Lou 110 Ph.
Lys Ser Thr Asn Ph.
Asn Ala Asn Lys Ph.
Lys His Thr Lou Lys Lys Thr INFORMATION FOR SEQ ID NO:1453: SEQUENCE CHARACTERISTICS: LENGTH: 225 amino acids TYPE: amino acid
SHEET
PCT/US 96/091?.2.
IPEAUS 16 DEC 1996 1020 TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...225 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1453 Pro Lys Ile Ala Pro Leu Ala Met Ala Leu Asn Pro Lys Thr Phe Gin 1 5 10 Pro Leu Trp Ile Ala Leu Val Arg Ala Thr Leu Leu Gly Trp Gly His 25 Arg Asn Leu Ser His Val Ala Gly Val Leu Asn Ala Ser Phe Leu Ala 40 His Phe Ile Lys Asp Pro Val Lys Thr Ala Lys Leu Ser His Lys Phe 55 Asn Asp Glu Arg Pro Tyr Pro Met Pro Ala Phe Ser Gln Phe Ser Asp 70 75 Gin Asp Leu Ser Asp Ile Val Ala Tyr Leu Thr Ser Ile Leu Pro Lys 90 Asn Leu Ser Asp Lys Glu Val Phe Ala Gln Ser Cys Gin Arg Cys His 100 105 110 Ser Leu Asp Tyr Ala Lys Asp Lys Ala Phe Ser Asp Pro Lys Asp Leu 115 120 125 Ala Asn Tyr Leu Gly Ser His Ala Pro Asp Leu Ser Met Met Ile Arg 130 135 140 Ala Lys Gly Glu His Gly Leu Asn Val Phe Ile Asn Asp Pro Gin Lys 145 150 155 160 Leu Leu Pro Gly Thr Ala Met Pro Arg Val Gly Leu Asn Glu Lys Ala 165 170 175 Gin Lys Gln Val Ile Ser Tyr Leu Glu Lys Ala Gly Asp Arg Lys Lys 180 185 190 His Glu Arg Asn Thr Leu Gly Ile Lys Ile Met Ile Phe Phe Ala Val 195 200 205 Leu Ser Phe Leu Ala Tyr Asp Trp Lys Arg Lys Val Trp Ser Glu Val 210 215 220 His 225 INFORMATION FOR SEQ ID NO:1454: SEQUENCE CHARACTERISTICS: LENGTH: 381 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_ feature LOCATION 1...381 PCTUS 96 09 12 2 iFENUS A. DEC 1996 1021 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:14 5 4 Thr Trp Arg Tyr Gin Leu Gly Ser Leu 1 Lys Giu Lys Pro Ser Phe Giu Tyr Leu 145 Pro Leu Giu Lys Giu 225 Arg Giu Phe Ph.
Phe 305 Phe Ile Leu Leu Ser Asn Thr Thr Glu Tyr His Se r 130 Ile Ser Gly As n Ala 210 I ile Lys Ser Phe Ile 290 Leu Ala Ser Giu Giu 370 Val1 Phe As n Ala Phe Gin Ala 115 Lys Asn Leu Lou Ala 195 Leu Leu Ser Pro Ile 275 Asp Lys Thr Asp Lys 355 Lys Giu Lys Leu As n Arg Gly 100 Thr Asp Thr Se r Ile 180 Met Giu Gin Val1 Lys 260 Met Giu Ala Thr Asn 340 Giu Ala
S
Ile Lou Leu Gin Lys Asn Ile Ile Thr Pro 165 His Phe As n Cys Tyr 245 Arg Val1 Ile Leu His 325 Giu Ser Leu Giu Ile Giu Val1 70 Ile Thr Pro Asn Ile 150 Met Ser Ile Leu Phe 230 Ile Lou Ser Giu Ph.
310 Asn Thr Ala Tyr Asn Asn Ala 55 Se r Lys Ala Leu Leu 135 Thr Thr As n Pro Gin 215 Asn Gin Lou Ile Ser 295 Lys Lys G ly Ser Arg 375 Tyr Phe 40 Lou Leu Lou Asn Thr 120 Asn Lys Met Leu Ile 200 Lou Pro Ile Asn Lou 280 Gly Leu Glu Val1 Gly 360 C iy Lys 25 Ph.
Tyr Pro Asp Pro 105 Ile Ser Pro Thr Asp 185 Giu Ala As n Lys Lou 265 Ile Leu Ala Ph.
Ph.
345 Ph.
Met Gly Lys Ile Ph. Giu His Gly Gin Asn Asn Thr Gly Giu His Ala Asp Asri Lou Ser Ile Arg Tyr Pro Thr 125 Asp Ala His 140 Lou Gin Ph.
155 Giu Ph. Giu Ile Ala Gin Ser Ile Val 205 Lys Giu Lys 220 Lou Asn Ala 235 Giu Asn Thr Gly Trp Gly Asn Arg Val 285 His Thr Lys 300 Lys Lou Gin 315 Lou Asn Ala Asp Ile Ala Arg His Ser 365 Val Arg Gly 380 Gin Leu Asp Lou Val1 Lys Thr 110 Gin Met Ser Arg Thr Asn Giu As n Pro Ph.
270 Lys Met Ile Ile Leu 350 Tyr Met Lys Ala Cys Asn Thr Giu Thr Thr Tyr Gin 175 Tyr Ser Lou Thr Lou 255 Ile Tyr Gin Gin Asn 335 Ph.
Sor INFORMATION FOR SEQ ID NO:1455: SEQUENCE CHARACTERISTICS: LENGTH: 284 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori
SHEET
t- 6/US 986/ 0912 APNUS 18 DEC 1996 1022 (ix) FEATURE: NAME/KE: misc-feature LOCATION .284 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1455 Thr His Cys Lou Phe Leu Gly Gly Ser Ile Lys Ile 1 Lys Thr Val1 Leu Gin Pro Gly Val1 Giu 145 Phe Ile Leu Ser Asp 225 G ly Glu Ala Glu Ile Leu so Asn Lys Leu Tyr Phe 130 Thr Gin Lys Tyr Tyr 210 Giu Lys Ile Ile G ly Lys Ile Pro Thr Ser Gly 115 Ser Ala Val1 Val1 Ile 195 Ser Arg Giu Thr Gin 275 Ilie Asp Gin Glu Giy Ala 100 Leu As n Pro Ile Val1 180 Gly Ala Gin Giu G iu 260 Asn As Asp Ser Asp Ile Phe Asn Giu As n Ser 165 Arg Giy Glu Val1 Tyr 245 Ile Ala Leu Phe Ser Phe 70 Asp Lys Ala G ly G ly 150 Pro Tyr Lys Ser Phe 230 Tyr Leu Leu Asn His Ile Pro 40 Asn Val 55 Tyr Asn Lou Ser Arg Glu Thr Phe 120 Lys Lou 135 Asp Ile Lys Ser Gly Thr Thr Gly 200 Tyr Asn 215 Thr Ile Ala Ser Val Arg Giu Lys 280 Gly 25 Ser Gly Giy Lou Val1 105 Lou Thr Tyr Ala Gly 185 Thr Sor Gly Lys Tyr 265 Asn 10 Tyr Lys Met Leu Glu 90 Lou Gin Thr Ile Arg 170 Lys Ala Ser Val1 Ile 250 Asn Arg Tyr Lys Ile Leu 75 Ala Lys Lou Pro Pro 155 Lys Asn Arg Ph.
Val1 235 Ala Tyr Leu Gin Ala Lys Gly Thr Gly Lou Tyr 140 Ser Met Ala Val1 Ph.
220 Ile Ala Leu Lys Lou Lou Val1 Ile Tyr Gly Sor Arg 125 Leu Pro Lys Gin Ala 205 Gly Lou Pro Ser Lou Gly Val Ser Gly Lys Val1 110 Ala Val Lys Glu Phe 190 Lys Phe Gly Ile Pro 270 i Lys Glu Lys Phe Ile Ser Tyr Gin Pro Thr 175 Glu Agn Ala Ser Phe 255 Sor Leu Tyr Asp Ser Ser Pro Tyr Ala Arg Thr 160 Lou Gly Gly Glu His 240 Lys Ile INFORMATION FOR SEQ ID NO:1456: SEQUENCE CHARACTERISTICS: LENGTH: 139 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: mnisc-feature LOCATION .139 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1456 AM37:;o SHEET uGTiUS 96/09122 IPEAUS 1 DEC i996 1023 Asp Lys Lys. Ile Leu Leu Ile Ile Gin Gly Lys Phe Met Glu Phe His 1 5 10 Gin Val Tyr Asp Pro Leu Gly His Ile Trp Leu Ser Ala Leu Val Ala 25 Leu Ser Pro Ile Ala Leu Phe Phe Ile Ser Leu Ile Val Phe Lys Leu 40 Lys Gly Tyr Ser Ala Gly Phe Leu Ser Leu Ala Leu Ser Ile Leu Ile 55 Ala Leu Phe Val Tyr Lys Met Pro Val Gln Met Val Ser Ala Ser Phe 70 75 Phe Tyr Gly Phe Leu Tyr Gly Leu Trp Pro Ile Ala Trp Ile Val Ile 90 Ala Ala Ile Phe Leu Tyr Asn Leu Ser Val Lys Ser Gly Tyr Phe Glu 100 105 110 Ile Leu Lys Glu Ser Val Gin Ser Ile Thr Leu Asp His Arg Ile Leu 115 120 125 Val Ile Leu Ile Gly Phe Cys Leu Ala His Phe 130 135 INFORMATION FOR SEQ ID NO:1457: SEQUENCE CHARACTERISTICS: LENGTH: 97 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...97 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1457 Pro Lys Pro Lys Gly Val Cys Pro Lys Asn Leu Met Ser Lys Arg Ala 1 5 10 Ile Arg Phe Pro Asn Lys Leu Phe Ser Tyr Pro Lys Pro Lys Ile Lys 25 Ala Thr Asn Thr Ser His Thr Val Leu Phe Ala Tyr Pro Leu Lys Pro 40 His Glu Met Ala Leu Leu Ala Leu Ala Thr Ser Leu Leu Ala Pro Ile 55 Phe Asn Ala Ile His Ser Thr Asn Ala Leu Asn Ala Ile Lys Pro Asp 70 75 Gly Thr Gly Ser Lys Ile Asn Pro Ile Ile Met Pro Met Lys Ile Gin 90 Lys INFORMATION FOR SEQ ID NO:1458: SEQUENCE CHARACTERISTICS: LENGTH: 532 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein MEN, PCT/U' 9 6 /0912 2 IPEUS 1 DEC 1996 1024 (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1...532 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1458 Arg Asn Asp Phe Lys Gly Val Arg Lys Met Ala Leu 1 Phe Ser Asp Gin Lys Thr Val Pro Lys 145 Leu Gin Gin Lys Ile 225 Phe Ile Lys Phe Ala 305 Leu Arg Asp Thr Asn 385 Lys Phe Ser Asp Ile Asn Leu Asn Asn 130 Ser Gly Trp Thr Thr 210 Val Leu Ser Ala Ser 290 Ser Gly Val Ile Tyr 370 Tyr Thr Cys Ile Asn Tyr Lys Lys Pro 115 Ile Met Glu His Gin 195 Thr Lys Ala Ser 110 275 Tyr Ala Trp Arg Ser 355 Thr Ile Val Phe Gin Val Thr Lys Ala 100 Phe Ala Arg Val Ala 180 Ala Ile Ser Ala Lys 260 Asn Leu Gly Phe Ile 340 Met Asn Phe Trp 5 Leu Lys Trp Giu Sen Leu Lys Asn Leu Leu 165 Leu Lys Gly Gin Leu 245 Tyr Phe Glu Leu Ile 325 Ala Leu Asn Thr Asp 405 Phe Gin Leu Lys 70 Lys Glu Asp Pro Lys 150 Lys Asp Arg Ile Val 230 Leu Ile Val Asn Ala 310 Ile Lys His Arg Thn 390 Gly Leu Met Lys 55 Glu Asp Ser Leu Ile 135 His Leu Lys Leu Phe 215 Lys Ser Glu Asn Val 295 Ile Leu Gly Ile Arg 375 Met Val Gin Ala 40 Lys Ser Leu Gin Ile 120 Ala Glu Leu Ser.
Glu 200 Gin Asn Val Asn Val 280 Thr Ala Ile Thr Thr 360 Ala Phe Asp Ala 25 Leu Phe Val Leu Gin 105 G1u Ile Asn Asp Ala 185 Leu Lys Gin Val Asn 265 Ser Tyr Met Gly Asp 345 Ile Gly Ala Phe 10 Glu Val Glu Arg Lys 90 Lys Arg Ile Leu Gin 170 Lys Gin Asp Leu Phe 250 Giu Val Leu Lys Gly 330 Ile Leu Arg Asn Cys 410 Asp Asp Asn Gin 75 Ile Met Pro Asp Lys 155 Lys Leu Gly Ser Phe 235 Ala Arg Ile Val Asp 315 Ser Phe Glu Ile Tyr 395 Val Lys Lys Tyr Glu Ser Phe Asn Gly 140 Asn His Sen Ala Asp 220 Lys Trp Val Val Thr 300 Leu Val Ile Asp Ile 380 Sex Th Arg Ser Lys Lys Leu Thr Glu Ile 125 Ile Asn Gin Asp Gin 205 Glu Leu Ile Tyr Leu 285 Val Phe His Gly Val 365 Phe His Phe /al Gin eu Ile Arg Leu Ser 110 Pro Ser Gin Leu Glu 190 Asn Ala Val Leu Thr 270 Ile Leu Met Val Asp 350 Thr Val Phe Asp Leu Glu Ala Tyr2 Arg Glu Tyr Asn Phe Thr Leu 175 Ile Ile Ile Tyr Lys 255 Val Phe Gly Ser Gly 335 Val Phe Pro Gly Ser 415 Leu Leu Lys Asn Leu His Gly Ile Ile Ser 160 Asn Tyr Leu Ser Val 240 Ile Asn Leu Phe Leu 320 Asp Leu Thr Asn Met 400 Asp Phe Lys Lys Ala Ser Lys Ile Ala Leu Asn Ile Ala Thr Giu Leu Ser 430 a a PCTUE9 0/091 a2 IPEMJS 1 DEC 19 9 6 Lys Arg Pro 465 Tyr Ala Leu Arg Giu Tyr 450 Glu Ala Phe Leu Giu 530 Tyr Thr 435 Ser Lou Asn Asn Thr Met Leu Lys 500 Lys Val 515 Gin Lys Asp Arg Gly Ser 485 Giu Asp Tyr 440 Se r Ile Ser Ile Ala 520 Gin Lys Val1 Ile 490 Ile Gly 102S Lou Asn Pro Arg 460 Trp Tyr 475 Val Ala Ala Tyr Asp Gly INFORMATION FOR SEQ ID NO:1459: SEQUENCE CHARACTERISTICS: LENGTH: 347 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .347 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1459 Arg Sor Glu Arg Met Gin Glu Ile Leu Ile Pro Lou Lys Glu Lys Ser 1 Tyr Ala Leu Ser Asn Gly Phe Val1 Lys 145 Leu Ala Arg ,Gin Lys Leu Lou Gly Ala Gly Arg Asp 130 Asn Ala Glu Leu Ser Val1 Ile Glu Glu Ph.
Gly Gly 115 Ala Lou Phe Ile 0 lu 195 Val1 Phe Ile Arg Lys Glu Val1 100 Ile Ser Ile Lou Ile 180 Thr As n
S
Lou Ser Leu Tyr Met Ile Asp Val1 Gly Lys 165 Lys Lys Ile is Gly Asp Asn Lys 70 Gin Ser Phe Gly Se r 150 Thr Met Asp Lys Glu Ser Ala 55 Asn Lou Asp Ile 0 ly 135 Phe Lou Ala Leu Ala 215 Lou Ile 40 Lou Ph.
Asn Met Asn 120 Lys His Giu Val1 Lys 200 Gin Pro 25 Val1 Glu His Arg Val 105 Ile Thr Gin Lys Cys Asp Vali G1u Ala Val1 Ser His 90 Gly Pro O ly Pro Arg 170 Ph.
Cys Val1 Ile Gly Arg Lou 75 Ser Ph.
Thr Ile Lys 0 iu Asp Lou Val1 Lys Lou Val Glu Leu Ala Thr Asn 140 Ala Phe Lys Giu Gin LeuI HIis :ys Arg met Sen Leu 125 Thr Vai Gin Asn Giu 205 Asp L6ys Lou V/al Ile Ile Ser 110 Lou Pro Ala Lou 190 Val1 Giu Gin Pro Ile Lou Ala Ile Ala Met Gly 175 Val Ile Lys Lys Tyr Asn Leu Gin Gly Asp 160 Val Giu Ph.
Giu 210 220 Ar; Asn Ile Ang Ala Gly Lou Asn Tyr Gly His Thr Pho Gly Met Lou r I M., 7-7 -1 16- PGT/L S/91.
IPENUS 16 DEC 1996 1026 225 Ilie Ala Leu Asp Arg 305 Leu Giu a lu Ile Thr Leu 290 Leu Pro Thr Asn a ly Leu 275 Ile Phe Lys Ile Giu Met 260 Lys Phe Leu Gly Leu 340 Thr 245 Arg Giu Asn Asp Val1 325 Lys 230 Asn Met Tyr Tyr Lys 310 Gly Val Arg Asp 265 Ile Thr Giu Giu Lys 345 Phe 250 Leu Giu Asp As n Ile 330 Trp 235 Leu Ala Asnr Ile Gin 315 Ala His His Leu Leu Gin 300 Thr Ser 240 Ile Met Phe Giu Ile 320 Lys INFORMATION FOR SEQ ID NO:i460: SEQUENCE CHARACTERISTICS: LENGTH: 196 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc-feature.
LOCATION .196 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:i460 Lys Ser Lys Ser Met Lys Leu Arg Arg Giy Lys Ile Met Pro Pho Sor 1 Lys Ser Leu Phe Giu Ala Arg Ph.
Leu 145 Asn Phe Leu Phe Lou Asn Phe Giu Ilie 130 Asp Ala Leu Val1 Lou Leu Ser Thr Phe GiU Lou Ile Val1 Phe Arg 100 Lou Ser Lys Gln 5 Asn Ala Lou Ile Tyr Val1 Ser Met Met Arg 165 Lou Lou Ser Gin 70 Ala Tyr Lys Lou So r 150 Tyr Thr Gly Asp 55 Ser Asn Lys Val Ph.
135 Lou Asp Aia Prc 25 Pho Le~ Phe Lys Arg Ile i Ile Lou Thr Val Ser Arg His Pro Lys Lys Gly Lou 90 Ile Pro Giu 105 Ser Lys Ile 120 Gly Ile Phe Giu Ser Ala Ala Lou Gly 170 Lou Gln 75 Tyr Ser Ph.
Trp His 155 Val1 Ile Thr Lys Met Lou Arg 140 Lys Arg Phe Ser Lou Thr Pro Ala 125 Lou Asn Phe Lys Asn Arg Cys Lou Leu Ser Lys Asp Ile Giu Asp Asn Lys Giu Ile Giu Lys 110 Lou Lou Ph.
Pro Lys Arg Giu Leu Glu 160 Giu Asp Ile 175 Ala Gly Val Asn 180 Lou Lys Lys Pro 195 Glu Val Lys Giu Lou Lou Giu Val 190 PCT/ /091 2 1027 IPEMJS DEC1996 INFORMATION FOR SEQ ID NO:1461: SEQUENCE CHARACTERISTICS: LENGTH: 179 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION 1...179 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1461 Met Lys Pro Leu His Phe Ser His Leu Asp Arg Glu Gin Ser Gly Asp 1 5 10 Val Gly Phe Ile Ile Lys Asn Leu Ile Phe Leu Gly Val Phe Ser Leu 25 Leu Gly Trp Leu Asn Thr Glu Tyr Phe Leu Trp Pro Ser Met Leu Glu 40 Leu Lys Lys Ile Leu Leu Glu Glu Asn Arg Lys Lys Ser Val Leu Glu 55 Tyr Ala Gln Arg His Phe Glu Thr Ala Leu Ala Asn Tyr Arg Asn Gin 70 75 Lys Glu Thr Ser Glu Ser Leu Leu Lys Ile Phe Asn Asp Glu Glu Ser 90 Arg Arg Ile Leu Glu Lys Ile Leu Lys Lys Cys Phe Asp Ala Tyr Lys 100 105 110 Ile Lys Pro Leu Leu Ser Gin Asn Pro Ser Gin Lys Thr Gln Phe Phe 115 120 125 Ile Met Ala Arg Ala Ser Glu Leu Glu Lys Thr Tyr Leu Phe Phe Thr 130 135 140 Leu Ile Asn Lys Tyr Leu Pro Ser Ala Gln Ser Gin Leu Pro Leu Lys 145 150 155 160 Ile Ser Lys Asp Ser Asp Gly Leu Leu Val Gln Phe Gly Val Ser Ile 165 170 175 Asp Leu Gin INFORMATION FOR SEQ ID N0:1462: SEQUENCE CHARACTERISTICS: LENGTH: 452 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...452 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1462 PCT/US 9 /09122 WENUS 0DlEC1996 1028 Phe Lys Arg Tyr 1 Arg Gly Ile Ala Gly Cys Asn Glu Ser 145 Asp His Ala Val Cys 225 Arg Val Val Val Ser 305 Ser Gly Cys Ser Leu 385 Ala Tyr Giu Gly Gly Ile Leu so Leu Pro Asp Gly Glu 130 Ser Val Leu Ala Leu 210 Gly Ala Ala Leu Val 290 GIn Giu His Ala Ile 370 Asn Leu Ser Lys Gin 450 Lys Ala Ile Val Met Ala Ile 115 Arg Tyr Ile Asn Tyr 195 Val Ala Asp Asp Gly 275 Ala Asp Cys Ile Leu 355 Ala Ile Leu Gly Leu 435 Leu Ala Ala Gly Ser Pro Gly 100 Lys Ala Lys Gly Leu 180 Lys Ile Leu Ile Asn 260 Val Thr Leu Met Ile 340 Gin Leu Gin Lys Thr 420 Leu Cys Phe 5 Gly Gly Lys Ala Thr Ile Phe Ile Val Arg 165 Gin Val Asn His Gly 245 Leu Tyr Ser Glu Arg 325 Phe Val Asn Lys Glu 405 Glu Glu Ile Val Leu Asp Leu 70 Pro Met Phe Glu Gly 150 Tyr Lys Ala Asp Pro 230 Phe Gly Gin Met Leu 310 Leu Ser Ser Pro Lys 390 Leu Asn Ser Thr Lys Tyr Thr 55 Thr Ala Ile Asn Glu 135 Glu Ile Leu Pro Glu 215 Asn Ala Asn Lys Ser 295 Lys Asn Asp Ala Phe 375 Pro Asp Lys Lys Met Leu Phe 40 Arg Ser Ile Ser Ser 120 Ile Ser Ala Arg Val 200 Pro Gin Phe Ile Ser 280 Asn His Lys Tyr Leu 360 Glu Pro Gin Leu Met 440 Lys Thr 25 Lys Lys Ile Ala Ala 105 Tyr Phe Val His Ile 185 Val Asn Leu Asp Val 265 Lys Leu Cys Ala Ala 345 Val Leu Leu Leu Arg 425 Gir Ile 10 Pro Lys Ser Gly Phe 90 Ser Gly His Gly Leu 170 Val Phe Gly Ser Gly 250 His Asn Ala Ala Asn 330 Lys Leu Tyr Glu Glu 410 Ile Glu Phe Met His Gly Tyr 75 Leu His Tyr Asp Ser 155 Lys Leu Ser Cys Gin 235 Asp Gly Ala Leu Ile 315 Phe Thr Glu Pro Ser 395 Ile Leu Leu Gly Phe Ser Tyr Asn Thr Asn Lys Glu 140 Ala His Asp Glu Asn 220 Glu Ala Asp Leu Lys 300 Gly Gly Gly Ser Gin 380 Leu Arg Leu Lys Thr Val Gin Met Val Glu Pro Leu 125 Glu Lys Ser Thr Leu 205 Ile Val Asp.
Lys Ser 285 Giu Asp Gly Asp Lys 365 Ser Lys His Giu Glu 445 Asp Met Thr Val Ile Asp Phe 110 Lys Leu Arg Phe Ala 190 Gly.
Asn Lys Arg Leu 270 Ser Tyr Lys Glu Gly 350 Leu Leu Gly Leu Ala 430 Phe Gly Lg Asn Glu Gln Met Glu Glu Leu Ile Pro 175 Asn Ala Glu Lys Leu 255 Leu Gln Leu Phe Gin 335 Leu Val Val Tyr Ile 415 Lys Phe Val Leu Lys Asn Ile Arg Asp Glu His Asp 160 Lys Gly Asp Gin Tyr 240 Val Gly Ala Lys Val 320 Ser Val Ser Asn Ser 400 Arg Asp Glu INFORMATION FOR SEQ ID NO:1463: SEQUENCE CHARACTERISTICS: LENGTH: Ill amino acids AM1P- -HFFT PCT/US 9 /0 0 91 2 S-LULU iJ96 1029 TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...111 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1463 Asn His Gin Arg Ile Arg Ser Arg Gin Gln Phe Arg Lys Pro Phe Asp 1 5 10 Pro Phe Arg Arg Ala Ser Glu Leu Lys Val Arg Ser Cys Lys Gin Ile 25 Phe Asp Lys Gly Leu Lys Pro Tyr Tyr Lys His Ser Val Cys Leu Lys 40 Pro Phe Phe Arg Phe Cys Phe Leu Lys Ile His Ala Tyr Gin Gln Arg 55 Tyr Arg Ala Phe Ala Leu Thr Leu Phe Ser Cys Lys Phe Phe Asn Ala 70 75 Cys Lys Ile Phe Ile Pro Ile Ile Asp Phe Lys Ile Val Phe Ile Pro 90 Ile Leu Lys His Gin Ala Lys Leu Lys Arg Val Ser Asn Ala Tyr 100 105 110 INFORMATION FOR SEQ ID NO:1464: SEQUENCE CHARACTERISTICS: LENGTH: 200 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...200 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1464 Lys Arg Met Lys Glu Ser Phe Tyr Ile Glu Gly Met Thr Cys Thr Ala 1 5 10 Cys Ser Ser Gly Ile Glu Arg Ser Leu Gly Arg Lys Ser Phe Val Lys 25 Lys Ile Giu Val Ser Leu Leu Asn Lys Ser Ala Asn Ile Glu Phe Asn 40 Glu Asn Glu Thr Asn Leu Asp Glu Ile Phe Lys Leu Ile Glu Lys Leu 55 Gly Tyr Ser Pro Lys Lys Thr Leu Ala Glu Glu Lys Lys Glu Phe Phe 70 75 Ser Pro Asn Val Lys Leu Ala Leu Ala Val Ile Phe Thr Leu Phe Val 90 Val Tyr Leu Ser Met Gly Ala Met Leu Ser Pro Ser Leu Leu Pro Glu PCT/1JS Ql 9 1 APNUS 1ADEC'j996 1030 Ser Gin Ile 145 Leu Cys Ile Leu 115 Ile Gly Ala Trp Ilie 195 1 Q0 Thr Gly Phe Ile Ph.
Leu As n Lou Ala 150 Thr Pro Ala His Ile 135 Leu Ser Ile Cys His 120 Val1 Trp Aia Ile Ala 200 105 Ser Asn Phe Met His Leu His Arg Gin 155 Ala Leu Ile 170 Ile Pro Ile 185 Leu C ly 140 Pro Ser Ser Asn 125 Arg Asn Ala Giy 110 Aia Cys Leu Asp Phe Tyr Met Ser Ser 160 Cys Gly Asn 175 Leu Met Gly 190 INFORMATION FOR SEQ ID NO:i465: SEQUENCE CHARACTERISTICS: LENGTH: 241 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Heiicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .24i (xi) SEQUENCE DESCRIPTION: SEQ ID NO:i465 Lys Giu Ser Leu Met Pro Ile Asn Pro Leu Tyr Lou Phe Pro Asn Leu Lr- 1 Ph.
Ser Ile Ser Gly Gly 11e Ser Cys 145 Lys Asn Thr Ser Leu Lys Val Arg Arg Phe 130 Val Lou Ile Aia Tyr Asp Ph.
Ala Ile Lou 115 Ile Lou Phe Arg Ser Gin G ly Gly Pro Gly 100 Ala Giy Leu Leu Tyr 180 Ser Phe Lou Ile Ser 8S Met Arg Ile Asp Gly 165 Pro Ile Vali Asp Giu 70 Lou Ala Ph.
Pro Asn 150 Ph.
As n Phe Lou Giy Met 25 Met Ala Cys Trp 40 Giy Arg Vai Ala 55 Ph. Asp Ser Lou Ilie Thr Tyr Ph.
90 Val Ser Ala Lou 10s Asn Ile Ser Thr 120 Ile Pro Ala Ala 135 Lys Tyr His Phe Ile Vai Lou Lou 170 Phe Lys Lys Vai 185 Phe Lou Sor Lou 200 tMet Giy Lou Tyr 215 Val Lys Ile Thr 4et Ser TyrA.
Leu Vai Arg Lou Ala Asp 75 Tyr Vai Ph. Val Asn Thr Ala Vai 140 Lou Giu 155 Giy Val Lys Trp Vai. Phe Lou Ile 220 Phe Asrq 235 Ile 1 Thr Val Gly Ile Ser 125 Lou Gly Leu Asn Val1 205 Tyr ~he lia ksn Jal Tyr Phe 110 Asp Val Asr Mel Le' 19 Ar Gi Ser Thr Ala *Asn Gly Pro *Val i Thr t Val 17 1 u Lysc 0 g Pr y 114 Lou Thr Phe Phe Ala Tyr Leu Giu 160 Ser Lou Lou e le sSer 24.0 Ph. Ile Lou Val Lou Ile 195 Giu Arg 225 Ala Lou Ser Val Phe 210 Trp Ile Pho Lou Met 23( Lys Asn Ly: 1-1 -1 1- I PENS u)19 9 6 1031 Ala INFORMATION FOR SEQ ID NO:1466: SEQUENCE CHARACTERISTICS: LENGTH: 251 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-.feature LOCATION .251 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1466 Tyr Lou Pro Ala Ser Glu Asn Ala Pro Leu Pro Sen 1 Sen Ser Arg Ph.
Tyr Phe Asn Leu Lou 145 Pro Glu Clu Lou Ile 225 Leu Ile Val1 Leu Asp Gin His Thr Lys 130 Phe Asn His Ser Glu 210 Gln Glu Val1 Gly Sen Leu Ser Asn Asn 115 Arg Sen Glu Ala Leu 195 Glu Lys I le
S
Ala Leu Lys Ile Ph. Gly Lys Ala Phe Asp Leu Ile 100 Glu Arg Phe Leu Ala Phe Ser Ser 165 Leu Phe 180 Asp Ser Tyr Ph.
Asn Ang Gly Asp 245 Sen Pro Leu Asp 70 Leu Asp Asp Asp Lys 150 Gly Glu Lys Lys
LYS
230 Ile Leu Ser Leu Leu Giu Cys I le Asn 135 Ang Phe Ala Ile Ser 215 Asn Lys Lys Gly 40 Lys Lys Val1 Asn Val 120 Pro Lou Ser Ph.
Glu 200 Val Ph.
Glu Ile 25 Ser I le Asn Lou Lou 105 Lys Lys Ala Thr Asn 185 Ala Lou Lou Ile Asp Lys I le Leu Giu 90 Sen Ile Asn Asn Ser 170 Ala Val Trp Ala 250 Ser Asp Ala Ph.
75 Lys Ile Ile Ala Ile 155 Lou Ile Ph.
Met Gly 235 I le Lou Pro His Glu Ph.
Ile Glri Gln 140 Asn Ph.
Lys Gly Asp 220 Val Ser Ph.
Ph.
Tyr Lys Leu Ang Lys 125 Lys Lys Lys Thr Lou 205 Lys Tyr Val Ph.
Sen Lou Ala Lou Gly Lou Val Gly Lou Giu Ser Val 110 Val Lys Lys Glu Asp Arg Glu Lou 175 Sor Thr 190 His Ala Asp Ile Gin Sen Ser Ph.
Ang Glu Val1 Arg Lou Ala Lou Asn 160 Gln Phe Pro Glu Phe 240 INFORMATION FOR SEQ ID NO:1467: SEQUENCE CHARACTERISTICS: LENGTH: 594 amino acids TYPE: amino acid TOPOLOGY: linear PC7/US q I I 7 IPEAUS 1 DEC 1996 1032 (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...594 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1467 Val Val Phe Lys lie Leu Ser Leu Trp Leu Gly Val Phe Cys Phe Leu 1 5 10 Arg Ala Thr His Leu Tyr Leu Gly Glu Glu Pro Lys Tyr Lys Asp Asn 25 Phe Thr His Phe Glu Tyr Ala Asn Pro Asn Ala Arg Lys Gly Gly Val 40 Leu Arg Asn Asp Ala Ile Gly Thr Phe Asp Ser Leu Asn Pro Phe Ala 55 Leu Lys Gly Thr Lys Ala Glu Gly Leu Asp Leu Ile Tyr Asp Thr Leu 70 75 Met Val Gln Ser Leu Asp Glu Pro Phe Ala Glu Tyr Pro Leu Ile Ala 90 Lys Asp Ala Glu Val Ala Lys Asp Asn Ser Tyr Val Ile Phe Thr Leu 100 105 110 Asp Lys Arg Ala Arg Phe Ser Asn Asn Ala Pro Ile Leu Ala Ser Asp 115 120 125 Val Lys Phe Ser Phe Asp Thr Ile Met Lys Leu Gly Ser Pro Leu Tyr 130 135 140 Arg Gln Tyr Tyr Gin Asp Val Lys Lys Ala Val Ile Leu Asp Lys His 145 150 155 160 His Val Lys Phe Ile Phe Lys Thr Thr Glu Asn Lys Glu Leu Pro Leu 165 170 175 Ile Leu Gly Gin Leu Gin Ile Phe Ser Lys Lys Ala Phe Gin Lys Asp 180 185 190 Tyr Phe Glu Lys Asn Pro Leu Leu Ile Pro Val Ser Ser .3ly Pro Tyr 195 200 205 Val lie Ala Ser Phe Asp Val Gly Lys Lys Ile Thr Tyr Gin Arg Asn 210 215 220 Pro Asn Tyr Trp Ala Lys Asn Leu Pro Ser Arg Lys Gly Gin Phe Asn 225 230 235 240 Phe Asp Gin Ile Lys Phe Glu Tyr Tyr Lys Asp Glu Thr Val Ala Leu 245 250 255 Gin Ala Phe Leu Ser Gly Ala Tyr Asp Trp Arg Leu Giu Ser Thr Ala 260 265 270 Lys Val Trp Ala Arg Gly Tyr Val Gly Lys Ala Met Asp Asn Lys Lys 275 280 285 Ile Thr Lys Tyr Leu Ile Ala His Lys Met Pro Ser Gly Met Gin Gly 290 295 300 Phe Phe Phe Asn Thr Arg Arg Glu Ile Phe Lys Asp Lys Arg Val Arg 305 310 315 320 Glu Ala Leu Phe Tyr Ala Phe Asp Phe Glu Trp Ala Asn Lys Asn Leu 325 330 335 Phe Phe Ser Gin Tyr Lys Arg Thr Thr Ser Phe Phe Ser Asn Ser Ile 340 345 350 Tyr Ala Ser Pro Pro Leu Pro Ser Pro Glu GIu Lys Ala Leu Leu Ala 355 360 365 Pro Tyr Glu Lys Ser Leu Asp Glu Arg Val Phe Lys Glu Pro Tyr Ile 370 375 380 Val Pro Arg Thr Asp Gly Pro Asp Val Leu Gly Tyr Asn Leu Arg Glu 385 390 395 400 Asn Leu Lys Tyr Ala Gin Lys Leu Leu Glu Ser Ala Gly Phe Ser Tyr 405 410 415 ~2
PC
T
/US 9 6 /0912 EA/US io UEC u9 i6 Lys Leu Lys Leu 465 Val Tyr Arg Ala Val 545 Tyr Ser Asn Leu Asn 450 Ser Gly Phe Ile Lys 530 Leu Arg Tyr Met Arg 420 Leu Asn 435 Leu Arg Gin Tyr Val Ile Gly Ser 500 Ser Ser 515 Asp Tyr Leu Arg Ile Ala Gly Phe Leu Ser Val Val Gly 485 Leu Lys Lys Gly Ala 565 Ser Val Pro Leu Asn 470 Gin Ser Ala Glu Phe 550 Tyr Pro Asp Lys Ala Phe 440 Gly Ile 455 Arg Ile Ser Ser Ala Lys Val Asp 520 Gin Leu 535 Tyr Ala Asn Tyr Tyr Leu Asn 425 Glu Glu Lys Phe Ala 505 Asp Ala Ile Ile Trp 585 1033 Asn Lys Pro Arg Leu Ala Met Lys Ile 460 Ser Tyr Asp 475 Pro Gly Asn 490 Lys Gly Thr Leu Ile Glu Ala Ile Gin 540 Pro His Phe 555 Gly Met Pro 570 Phe Leu 445 Gin Phe Glu Arg Arg 525 Ala Tyr Glu Ser 430 Ala Arg Asp Gin Asn 510 Ile Met Leu Ile Phe Phe Val Met Arg 495 Tyr Ile Asp Pro Ser Thr Ala Asp Ile 480 Phe Ala His Arg Asn 560 Pro Trp Ile Lys Lys 575 Glu Arg Gly 590 Pro Lys INFORMATION FOR SEQ ID NO:1468: SEQUENCE CHARACTERISTICS: LENGTH: 201 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION 1...201 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1468 Ser Val Ile Gly Val Tyr Ile Ile Ser Leu Lys Glu 1 Leu Arg Phe Ser Leu Leu His Val Val Val Phe Glu Tyr His Ile Tyr 135 Val Leu Asp Leu Val Tyr Leu Asp 120 Trp Phe 10 Ser Ile Asn Ala Leu Asp Leu Tyr Pro Ser Lys Lys Ser Thr Glu Thr Pro 125 Thr His Arg Lys Gin Leu Pro Val Glu Asp Phe Phe i 9 6 0 91 2 2 1034 iPEUS 1 996 145 150 155 160 Asn Asn Pro Ile Leu Glu Lys Phe Lys Lys Phe Phe Asp Val Ser Arg 165 170 175 Phe Leu Asn Leu Ser Thr His Lys Val Ile His Leu Tyr Ser Gln Lys 180 185 190 Asn Thr Lys Lys Leu Leu Arg Asn Ala 195 200 INFORMATION FOR SEQ ID NO:1469: SEQUENCE CHARACTERISTICS: LENGTH: 540 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...540 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1469 Phe Ser Glu Arg Asp Phe Glu Leu Phe Arg Gin Lys Thr Asn Pro Tyr 1 5 10 LS Glu Arg Cys Ser Cys Gly Phe Gly Phe Leu Set Asp Ala Ser Lys Arg 25 Ser Leu Asn Pro Thr Leu Met Met Asn Asn Asn Asn Thr Leu Pro Lys 40 Pro Leu Glu Glu Ser Leu Asp Leu Lys Glu Phe Ile Ala Leu Phe Lys 55 Thr Phe Phe Ala Lys Glu Arg Gly Ser Ile Ala Leu Glu Asn Asp Leu 70 75 Lys Gin Ala Phe Thr Tyr Leu Asn Glu Val Asp Ala Ile Gly Leu Pro 90 Ala Pro Lys Ser Val Lys Glu Ser Asp Leu Ile Val Val Lys Leu Thr 100 105 110 Lys Leu Gly Thr Leu His Leu Asp Glu Ile Tyr Glu Ile Val Lys Arg 115 120 125 Leu Arg Tyr Ile Val Val Leu Gin Asn Ala Phe Lys Pro Phe Thr His 130 135 140 Leu Lys Phe His Glu Arg Leu Asn Ala Ile Ile Leu Pro Pro Phe Phe 145 150 155 160 Asn Asp Leu Ile Leu Leu Leu Asp Asp Glu Gly Gin Ile Lys Gin Gly 165 170 175 Ala Asn Ala Thr Leu Asp Ala Leu Asn Glu Ser Leu Asn Arg Leu Lys 180 185 190 Lys Glu Ser Thr Lys Ile Ile His His Tyr Ala His Ser Lys Glu Leu 195 200 205 Ala Pro Tyr Leu Val Asp Thr Gln Ser His Leu Lys His Gly Tyr Glu 210 215 220 Cys Leu Leu Leu Lys Ser Gly Phe Ser Ser Ala Ile Lys Gly Val Val 225 230 235 240 Leu Glu Arg Ser Ala Asn Gly Tyr Phe Tyr Leu Leu Pro Glu Ser Ala 245 250 255 *Gin Lys Ile Ala Gin Lys Ile Ala Gln Ile Gly Asn Glu Ile Asp Cys 260 265 270 Cys Ile Val Glu Met Cys Gin Thr Leu Ser Arg Ser Leu Gln Lys His 275 280 285
T
PCTUS 9 6/O091 1PENUS 16 DLC 1996 1035 Leu Leu 305 Met Pro Met Lys Lys 385 Ala Ala Leu Ser Gin 465 Giu Giu Ala Lys Leu 290 Gin Pro Ile Leu Ser 370 Ilie Ile Gly Leu Ser 450 Ile Asn Arg Phe Arg 530 Phea Leu Lys Phe Leu Phe Lys Giu Phe 295 Ala Ser Leu Ala 355 Leu Asn Ile Arg Giy 435 Leu Vali Lys Pro Glu 515 Lys Arg Phe Lys 340 Val Leu Ala Asn Met 420 Val1 Tyr Ile Giu Thr 500 Thr Pro Leu Thr 325 Glu Thr Ser His Asp 405 Lys Asp Lys Thr Val1 485 Tyr Ala Ser Asn 310 Gin Pro Gly Ala His 390 Pro Gin Giu Thr Thr 470 Giu Thr Leu Met Phe Lys Lys Val Ala 375 Ser Gin Phe Ile Leu 455 His Leu Phe Arg Ala 535 Ala Lys Pro Asn 360 Phe Thr Asn Ser Giu 440 Leu His Leu Leu Tyr 520 Lys Lys Met Leu 345 Ala Leu Ile Ser Ala 425 Leu Giu Lys Ala Lys 505 Gly Ile Ala Ile 330 Asn Gly Ser Pro Ala 410 Leu Gly L~ys Arg Ala 490 Gly Val1 Arg Tyr 315 Leu Leu Gly Lys Tyr 395 Asn Leu Thr Leu Leu 475 Leu Val1 Pro Lys Asp 300 Asn Glu Lys Lys His 380 Phe Asn Ser Asp Leu 460 Ser Ile Pro Asn 540 Phe Leu Asn Phe Thr 365 Leu Arg Ile Lys Ala 445 Lys Val1 Asp G ly Ph.
525 Leu Giu Phe Giu 350 Met Ile Giu Ser Giu 430 Asp Gin Leu Giu Lys 510 Leu Asp Ph.
Ser 335 Lys Leu Pro Ile Thr 415 Asn Giu Asn Met Glu 495 Ser Ile Ser Val1 320 His Ser Leu Met His 400 Ph.
Met Ala Asn Ala 480 Lys Ty'r Glu INFORMATION FOR SEQ ID NO:i470: SEQUENCE CHARACTERISTICS: LENGTH: 455 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL; YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .455 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1470 Lys Leu Thr Glu Lys Ile Met Leu Glu Thr Pro Lys Val Leu Leu Lys 1 5 10 Asn Leu Gin Asp Cys Lys Ile His Ph. Ile Gly Ile Gly Gly Ile Gly 25 Ile Ser Gly Leu Ala Lys Tyr Leu Lys Ala Gin dly Ala Lys Ile Ser 40 Gly Ser Asp Ile Ala Ile Ser Pro Sen Val Lys Tyr Leu Lys Ala Leu s0 55 Giy Val Giu Ile Asn Ilie Pro His Asp Pro Lys Ala Ile Asn His Gin 70 75 Asp Val Ile Ile His Ser Ala Ile Ile Lys Giu Asp Asn Thr Giu Ile
HE~T
-0 69 1036 Gin Arg Leu Tyr His Giy 130 Phe Gly 145 Arg Giu Ser Ser Giu Pro Phe Ala 210 Lys Giu 225 Giu Lys Pro Tyr dly Leu Ala Leu 290 Phe Lys 305 Ile Leu Leu Lys Ile Ilie Leu Glu 370 Ile Leu 385 Lys Ala Lys Lys Th Ile Tyr Gin 450 Ala Se r 115 Lys Aia Se r Phe Giu 195 Tyr Asp Lys Thr Gly 275 Asp Gly Ile Ser Val1 355 Giu Pro His Gly Glu 435 Leu Lys 100 Ilie Ser Ile Ala Leu 180 His Lys Pro Asp Ser 260 Giu Giu Ile Asp Ala 340 Ilie Phe Val1 Phe Asp 420 Lys Arg Giu Leu Ser Ile Asp 165 Phe Leu Tyr Phe Ile 245 Phe His Leu Lys Asp 325 Arg Trp Lys Tyr Lys 405 Phe Gly G ly Leu Lys Ile Gly 150 Met Ser Glu Phe Leu 230 Tyr Glu As n Asn Lys 310 Tyr Ile Gin Lys Ser 390 His Leu Phe Glu Giu Asp Thr 135 Ala Ser Asn His Leu 215 Lys As n Leu Ala Leu 295 Arg Ala Tyr Ala Cys 375 Ala Tyr Glu Val.
Met 455 Ile Lys 120 Ala His Leu Pro Tyr 200 Asp Asn Ile Lys Thr 280 Giu Phe His Ala His 360 Phe Ser Asn Leu Ile 440 90 Pro Ile 105 Arg Val Met Leu Ser Lys Val Phe 170 Phe Cys 185 Asp His His Ala Tyr Ser Gin Tyr 250 Asn Leu 265 Asn Ala Glu Ile Asp Ile His Pro 330 Asn Leu 345 Lys Tyr Leu Glu Glu Val Pro Thr 410 Leu Val 425 Leu Phe Ser Glu 155 Giu Ala Asp Gin Lys 235 Ile Gly Ser Arg Leu 315 Thr Leu Ser His Lys 395 Phe Asn Ser Ser Ala 140 Phe Ala Ile Leu Lys 220 Asp Leu Ala Leu As n 300 Gin Glu Asn Arg Cys 380 Arg Ile Asp Arg Lys Asp Ala 110 Val Cys Gly Ala 125 Ile Cys Pro Ala Asp Ser Asn Val 160 Asp Glu Ser Asp 175 Val Pro Asn Thr 190 Glu Arg Phe Phe 205 Arg Val Ile Tyr Ala Ile Val Leu 240 Lys Asp Gly Giu 255 Phe Leu Val Trp 270 Ala Ile Leu Ser 285 Asn Leu Leu Asn Lys Asn Asp Leu 320 Ile Gly Thr Thr ~335 Thr Gin Giu Lys 350 Leu Met Asp Asn 365 Asp Arg Leu Ile Asp Ile Asp Leu 400 Asp Arg Val Arg 415 Asn Val Val Glu 430 Gly Asp Ile Thr 445 Gly Phe Gly Ala INFORMATION FOR SEQ ID NO:1471: SEQUENCE CHARACTERISTICS: LENGTH: 67 amino acids 1B) TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature
SKEET
PCI/9 96/091 P~~MJ~ L96 1037 Ala Gly Asn Ala Leu LOCATION .67 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:147i Val Thr Ala Ile Leu Giy Trp Asp Giu Giu Giy Lys 10 Lys Ile Arg His Lys Tyr Leu Giu Thr Ser Asn Val 25 Ala Leu Thr Asn Leu Ile Leu Met Gin Arg Gly Tyr 40 Arg Ala Phe Gly Ala Gly Asp Asp Met Ile Lys Giu 55 Lys Lys Leu Lys Phe Asn Ala Gly Ser Met Asn Ala Ile Ser INFORMATION FOR SEQ ID NO:i472: SEQUENCE CHARACTERISTICS: LENGTH: 186 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .186 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1472 Lys Leu His Arg Gly Sen Gin Lys Gin Asn Pro Ile 1 Trp Pro Lys Leu met Val Gin Thr Val 145 Phe Phe Giu Met Sen Leu Arg Val1 Gly Ile 130 Gly Arg As n Gly Asp Met Ser Giu Val Lys Giu Gly Gin 165 Arg 5cr Gly Thr Arg Val Ile Gly 120 Pro Gin Cys Tyr Ala Asn Lys Lys Ile Gly 105 Asn Leu Val Arg Glu 185 Thr Lys Leu Pro Sen 90 Ile Leu Sen Trp Giu 170 Arg His Leu Phe Arg Leu Leu Tyr Giy Giu 155 Arg Lys Thr Tyr G ly Ala Ala Giu Asn.
140 Asn Pro Asn Met Tyr Gin Ile Phe Ph.
Met 125 Arg Gin Asn Asp Lys Ser Asp Ph.
Ser Thn 110 Gin His Ala Gin Pro Ser Leu Ser Arg Asn Asn Giu Ph.
Gin Ser 175 Thr Ala Asp Lys Asp Gly Asp Gly Arg Ile 160 His INFORMATION FOR SEQ ID NO:i473: SEQUENCE CHARACTERISTICS: AMEDIo SHJEET P 9 6/0912 2 IPfENUS i 0tC1996 1038 LENGTH: 172 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...172 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1473 Trp Met Phe Val Val Lys Met Val Leu Gly Phe Leu Ile Leu Leu Ser 1 5 10 Pro Leu Cys Ala Thr Gly Leu Asp Ile Ser Gln Thr Asp Ile Ile Glu 25 Arg Ser Leu Asn Phe Leu Leu Phe Val Gly Ile Leu Trp Tyr Phe Leu 40 Ala Lys Arg Leu Arg Ser Phe Leu His Ser Lys Ser Leu Glu Ile Ser 55 Lys Arg Leu Glu Glu Ile Gln Ala Gln Leu Lys Val Ser Lys Glu His 70 75 Lys Lys Lys Leu Leu Lys Glu Leu Glu Gln Ala Lys Glu Lys Ala Glu 90 Leu Ile Ile Ser Asp Ala Asn Lys Glu Ala Tyr Thr Ile Thr Gin Lys 100 105 110 Tyr Glu Leu Gln Thr Lys Met Asp Val Glu Asn Leu Ile Lys Asn Ser 115 120 125 Lys Ala Leu Met Asp Leu Glu Val Lys Lys Ile Lys Arg Glu Leu Val 130 135 140 Glu Ser Val Phe Lys Asp Leu Arg Glu Ser Lys Lys Val Ser Phe Asn 145 150 155 160 Ala Gin Asp Cys Val Asn Ile Leu Lys Gin Arg Leu 165 170 INFORMATION FOR SEQ ID NO:1474: SEQUENCE CHARACTERISTICS: LENGTH: 248 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...248 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1474 Met Gln Lys Ser Ile Phe Lys Ile Thr Leu Leu Leu Val Phe Leu Phe 1 5 10 Leu Arg Asn Ala Val Gly Leu Asp Asp Lys Lys Ala Ala Pro Lys Ser 25 IPENUSi D f99 1039 Val Gln Asn Thr Pro Lys Asn Leu Pro Pro Ile Gln Leu Arg Leu Asp 40 Gin Ala Tyr Glu Asp Leu Ile Lys Met Leu Asp Asn Met Gly Lys Ser 55 Thr Gln Tyr Glu Phe Pro Lys Ile Lys Glu lie Leu Glu Gln Ser Glu 70 75 Glu Glu Trp Leu Gly Val Ala His Glu Glu Cys Val Ala Leu Val Met 90 Leu lie Ser Pro Lys Ala Ser lie Glu Asn Ser Pro Ile Tyr Lys Asn 100 105 110 Cys Tyr Glu Ala Tyr Val Lys Gln Arg Ile His Asp Leu Tyr Asp Phe 115 120 125 Tyr Ile Glu Gly Lys Lys Val Lys Arg Lys Ile Lys Lys Ala His Glu 130 135 140 His Glu Met Ala Leu Asn Lys Ser Gln Pro Leu Lys Lys Glu Pro Pro 145 150 155 160 Lys Ser Glu Asn Lys Lys Gly Leu Thr Lys Pro Ser Leu Lys Asp Ala 165 170 175 Lys Ile Pro Lys Gly Tyr Tyr Leu Gln Ile Gly Ala Phe Leu Asn Ser 180 185 190 Pro Ser Lys Asp Phe Leu Gln Thr Leu Lys Thr Phe Pro His Gln Met 195 200 205 Glu Glu Lys Asp Ser Leu Thr His Tyr Leu Ile Gly Pro Tyr Lys Thr 210 215 220 Lys Glu Glu Ala Leu Lys Gln Leu Glu Asn Ala Ala Lys Ser Phe Lys 225 230 235 240 Asn Lys Pro Ala Leu Val Glu Lys 245 INFORMATION FOR SEQ ID NO:1475: SEQUENCE CHARACTERISTICS: LENGTH: 227 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...227 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1475 Ser Gly Cys Tyr Phe Glu Ser Asn Ser Asp Val Tyr Val Val Ile Ile 1 5 10 Gly Leu Ala Asp Gin Lys Ile Gly Val Ile Val Asp Tyr Leu Ile Gly 25 Gin Glu Glu Val Val Ile Lys Ser Leu Gly Tyr Tyr Leu Lys Asn Thr 40 Arg Gly Ile Ala Gly Ala Thr Val Arg Gly Asp Gly Lys Ile Thr Leu 55 Ile Val Asp Val Gly Ala Met Met Glu Met Ala Lys Ser Ile Lys Val 70 75 Asn Ile Thr Thr Leu Met Asn Glu Ser Glu Asn Thr Lys Ser Lys Asn 90 Ser Pro Ser Asp Tyr Val Val Leu Ala Ile Asp Asp Ser Ser Thr Asp 100 105 110 Arg Ala Ile Ile Arg Lys Cys Leu Lys Pro Leu Gly Ile Thr Leu Leu PCTUS 96/091 2a2 1PEANS 16 DEC 1996 1040 Glu Lys 145 Gly Leu Arg Oly Asp 225 115- Thr Pro Thr Leu Val1 195 Tyr Ser Gly Ala Ala 165 Ala Ser Thr Leu I le 150 Ser Val1 Gly Thr Glu 135 Leu Glu Thr Met Val1 215 Leu 140 Met Asn Lys Thr Ile 220 125 Lys Pro Lys Thr Lys 205 Lys INFORMATION FOR SEQ ID NO:1476: SEQUENCE CHARACTERISTICS: LENGTH: 276 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .276 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1476 1Met Thr Leu Ser Gin Ala Leu Asn Lys Ala Lys Lys Glu Leu Ser Pro is Lys Leu Ser Asn Arg Glu Lys Leu Pro 145 Lys Thr Pro Gly Gin His Asp Ser Ile Glu Ala 130 Lys Giu Ile Leu Phe Lys Glu Cy.
Ph.
Leu Ile 115 Leu Ala Arg Glu Giu 195 Arg Giu Giu Pro Phe Val 100 Gly Giu Leu Val1 Met 180 Lys Gly Arg Glu Ile Val Gin Giu Asn Giu Phe 165 Leu Ser Gly Val Thr Glu 70 Asn Lys Ile Pro Val1 150 Leu Val1 Val1 Leu Phe Arg 55 Tyr Giu Ala Gly Asn 135 Ala Lys Ser Lou Ile 215 Glu Leu 40 Ph.
Leu His Leu Ile 120 Leu Leu Gln Asn Lys 200 Ser His Phe Leu Val1 Asn 105 Gly Ser Lys Thr Pro 185 Glu Glu Ile Leu Leu Gly Ph. Val Thr Glu Gly Leu 90 Ile Ser Ile Asn Arg 170 Pro Pro His Leu Ser 75 Ile Ile Gly Ile Lou Tyr His Glu Val Cys Pro Ser Cys Ala 140 Giu Trp Ile Glu Val1 220 His 0 ly Asp Arg Gin Val 125 Ser Arg Asp Ala Ala 205 Lys Phe Pro Tyr 110 Ser Asp Ph.
His Arg 190 -Leu ilu Ang Tyr Giu His Val Ile Cys Met 175 Asn Phe Lou Leu Gly Thr Leu Ser Ser Lou 160 Pro Tyr Gly Gly Val 210 Lys Gly Asp Glu Leu Lys Glu Ile Phe Leu Ala Ala IPENUS 16u i96 1041 Lys Leu Lys Ile Pro Phe Leu Val Cys Glu Met Gly Tyr Asp Gin Leu 225 230 235 240 Lys Ser Leu Lys Glu Cys Leu Glu Phe Cys Gly Tyr Asp Ala Glu Phe 245 250 255 Tyr Lys Asp Leu Ser Gly Phe Asp Arg Gly Phe Val Gly Val Leu Lys 260 265 270 Ser Phe Leu Arg 275 INFORMATION FOR SEQ ID NO:1477: SEQUENCE CHARACTERISTICS: LENGTH: 188 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION 1...188 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1477 Lys Ala Val Leu Phe Asn Pro Leu Pro Thr Lys Arg Ser Val Met Pro 1 5 10 16 His.Ser Leu Lys Lys Arg Phe Leu Ile Val Tyr Thr Leu Ser Thr Leu 25 Leu Leu Val Gly Val Leu Leu Ala Leu Phe Phe Phe Tyr Ala Lys Asn 40 Asn Leu Leu Glu Asn Thr Gln Ile Arg Met Gln Tyr Thr Ala Asp Ala 55 Ile Ala Lys Ser Leu Leu Glu Leu Asn Asn Ala Ser Ser Leu Glu Pro 70 75 Leu Lys Ile Leu Glu GIu Arg Phe Lys Asn Thr Pro Phe Val Leu Leu 90 Asp Ala Asp Asn Arg Val Lys Phe Ser Asn Ile Gly Val Phe Val Ala 100 105 110 Ser Phe Lys Asn Asp Ala Leu Ile Lys Thr Pro Tyr Phe Ala Leu Lys 115 120 125 Lys Gln Gly Phe Tyr Leu Thr Asp Ser Ala Pro Thr Asn Arg Leu Gly 130 135 140 Val Ser Lys Ile Ile Ile Ala Glu Glu Glu Ile Gln Lys Ile Phe Ile 145 150 155 160 Pro Leu Tyr Lys Met Ile Gly Tyr Val Phe Leu Gly Ala Ser Leu Phe 165 170 175 Val Ala Leu Ile Ala Met Trp Leu Tyr Lys Ile Pro 180 185 INFORMATION FOR SEQ ID NO:1478: SEQUENCE CHARACTERISTICS: LENGTH: 408 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein AM E"ED SHEET iPENU £DEC2 1996 1042 (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Holicobacter pylori (ix) FEATUJRE: NAME/KEY: misc-feature LOCATION .408 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:i478 Asn Leu Phe Asp Ile Phe Giu Ser Lys Phe 145 Tyr Ser Pro Asp Ser 225 Asn Asp Giy Gly Leu 305 Ser Ala Asp Lou Phe 385
LYS
Met Leu Asp Ile Trp Ile Asp Met Phe Ile Tyr so Ile Gly Thr Val1 Giu 130 Phe Thr Phe Lys Lou 210 Gin Ala Thr His Ile 290 Pro Lou Met Lys Vali 370 Tyr Ala Phe Arg Glu Ser Lou Lou Lou 115 Phe Lys Lou Phe Ile 195 Giu Gly Tyr Leu G iu 275 Met Pro Ile Pro Ph.
355 Ser Val1 Lou Thr Thr Pro Gin Lys Lou Giu Ala Giy Gin Ile Lou 70 Thr His Lou 8s Gly Tyr Lou 100 Ala Lou Pro Gly Ph. Ser Gly Lou Lou 150 Ile Met Ilie 165 Vai Val Phe 180 Ala Gin Leu Ser Gin Ilie Ile Ph. Val 230 Ph. Gly Gly 245 Ile Sor Lys 260 Lou Giy His Gly Gly Lou Lou Val Ph.
310 Thr Ile Leu 325 Lou Ile Gly 340 Giy Ala Ser Ile Val Asn Phe Lou His 390 Asp Tyr Giu Tyr Cys Asn 55 Asp Giu Val1 Ile Lys 135 Lou Ile Val1 Ph.
Giu 215 Met Lou Val1 Ph.
Leu 295 Giu Leu Ph.
Lou Giu 375 Ph.
Ile Giu 40 Tyr Gly Asp Ph.
Ser 120 Vali Thr Giu Phe As n 200 Ser Asp Gly Gly Lys 280 Ala Gly Lou Ph.
Ser 360 Asn Thr Val1 25 Lys Ala Val1 Lou Ala 105 Tyr Ser Lou His Met 185 Gin Met Ala Lys Thr 265 Asn Lou Ph.
Ph.
Ser 345 Ser Lys His Ile Ile Cys Giy Asp Ile Pro Val Lou Ilie Arg Lys Ile Phe Ala 75 Thr His Tyr 90 Lou Lou Ph.
Tyr Thr Thr Lou Ser Lou 140 Giy Val Gly 155 Val Giu His 170 Ile Leu Ala Ph. Thr Pro Met Asp Lys 220 Ser Lys Arg 235 Asn Lys Arg 250 Giu Gly Lou Lys Asp Lou Val Ph. Ala 300 Asn Val Ser 315 Lou Pro Val 330 Arg Lys Asn Lys Glu Thr Ala Ph. Pro 380 Pro Pro Lou 395 Ile Leu Lou Met Gly Lou Leu Met 125 Ph.
Lou Trp As n Lou 205 Val1 Asp Val Lou Lou 285 Leu Gln Ph.
Giu Lou 365 Tyr Lou Ph.
Gin Pro Gin Trp Asn Ala 110 His Ph.
Lou Glu Lou 190 Asn Gly Gly Val1 Aia 270 Lys Ile Thr Ser Tyr 350 Ala Ser Giu Tyr Leu Gin Leu Val1 Lou Ile Leu Lys Lou Ile 175 Ph.
As n Ph.
Arg Lou 255 I le Asn Ala Pro Ph.
335 Asn Lys His Arg Leu Lys Lys Son Ph.
Pro Gin Asp Asp Ile 160 Ser Tyr Ang Lys Lou 240 Phe Lou Lou His Ala 320 Tyr Ala Ala Pro Lou 400 Ile GiU PCThs 9 /0912 2 IPEAUs D0EC 1996.
1043 INFORMATION FOR SEQ ID NO:1479: SEQUENCE CHARACTERISTICS: LENGTH: 144 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...144 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1479 Ile Arg Arg Arg Pro Ile Val Ser Asn Gln Leu Lys Asp Leu Phe Glu 1 5 10 Arg Gln Lys Glu Ala Asn Ala Ser Ser Lys Gln Glu Asp Asn Glu Glu 25 Ile Leu Gln Phe Ile Gly Phe Ile Ile Gly Asp Glu Glu Tyr Ala Ile 40 Pro Ile Leu Asn Ile Leu Glu Ile Val Lys Pro Ile Gly Tyr Thr Arg 55 Val Pro Glu Thr Pro Asn Tyr Val Leu Gly Val Phe Asn Leu Arg Gly 70 75 Asn Val Phe Pro Leu Ile Ser Leu Arg Leu Lys Phe Gly Leu Lys Ala 90 Glu Lys Gin Asn Lys Asp Thr Arg Tyr Leu Val Val Arg His Asn Asp 100 105 110 Arg Ser Leu Gly Phe Ser Ser Leu Ser Gly Leu Met Pro Ser Glu Ser 115 120 125 Ala Ser Thr Ile Asp Pro Ser Gln Lys Leu Cys Ala Ile Thr Ile Ile 130 135 140 INFORMATION FOR SEQ ID NO:1480: SEQUENCE CHARACTERISTICS: LENGTH: 299 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION 1...299 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1480 Ser Phe Ser Ile Asn Ser Phe Lys Lys Ala Lys Gly Met Lys Ser Thr 1 5 10 Arg Ile Gly Ser Lys Ile Val Met Met Val Cys Ala Val Val Ile Val 25 lie Ser Ala Val Met Gly Val Ile Ile Ser Tyr Lys Val Glu Ser Val 4 31m i~~MJ$E IiC1996 1044 Leu Gin Ser 40 Leu Gin Ala Thr Glu Ser Thr Leu Leu Ala Glu 145 Asp Ile Asn Lys Asn 225 Asp Giy Ala Ser Phe Leo Lys Leu Met 130 Asn Pro Thr Phe Lys 210 Pro Lys Thr Ile Leu 290 Lys Giu Arg Val2 1125 Asn Met Tyr Leu Phe 195 Ser Asn Arg Leu Gin 275 Ala C ly Leu Leu Ile Ser Gin 150 Giu Met Ile Phe Ile 230 Lys His Asp Asn Ile Met Ser Asp Ser Giu Tyr Thr 2.20 Lys Ile 135 Ile His Val Asn Giy Lys Asp Ala 200 Leu Met 22.5 Gin Asp Ala Va 1 Ser Leu Phe Phe 280 Trp Giu 295 Leu Gin Lys Lys Arg Ile 75 Glu Asn Gly Phe Leu Leu 105 Asn Asn Asn Ala Tyr Pro Ser Leu Lys 155 Giy Asp Lys 170 Asn Gin Asn 185 Phe Tyr Thr Giy Lys Asp Lys Ilie Leu 235 Glu Tyr Tyr 250 Ser Gly Asn 265 Giu Giu Lys Ile Cys Gin Ala Met Ile Asn Arg 125 Thr Ile Tyr Ile Val1 205 Arg Ala Gin Glu Asn 285 Gin Gly Asn Pro 110 Met Ala Thr Giy Gly 190 Val1 Ile Ile Asn Thr 270 Asn Leu Ala Asp His Ile Leu Arg Met 2.75 Ala Gly Leo Asn Glu 255 Phe Gly Val Asn Thr Val Thr Asn Ser 160 Asp Leu Lys Ile Pro 240 Ala Leu Gin INFORMATION FOR SEQ ID NO:i48i: SEQUENCE CHARACTERISTICS: LENGTH: 101 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .101.
(xi) SEQUENCE DESCRIPTION: SEQ ID NO:1481 dly Val Phe Tyr Asn Ser Ser Leu Pro Gin Pro Pro Thr Lys Asn 1 5 10 Leu Thr Arg Giu Tyr Arg Phe Leu Lys Arg Leu Ser Leu Ile Tyr 25 Sen Sen Phe Ile Val Phe Ilie Leu Lys Asn Ala Leu Lys Leo Phe 40 4S Ile Leo Leu Leo Met Leo Asn Lys Pro Lys Pro Leu Phe Leo Leu 55 Val Lys Pro Phe Phe Tyr Leu Phe Asp Leu Val Ala His Leo Ser 70 75 Pro Ala Leo Leo Thr PCTiu 9 /0 91 2 IPENUS 1 DEC 1996 1045 Arg Ile Asp Leu Ile Asp Lys His Val Lys Val Tyr His His Gin Lys 90 His His His Lys Pro 100 INFORMATION FOR SEQ ID NO:1482: SEQUENCE CHARACTERISTICS: LENGTH: 111 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...111 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1482 Phe Ile Thr Gly Ile Glu Ile His Pro Gly Ala Lys Ile Gly Arg Gly 1 5 10 Leu Phe Ile Asp His Gly Met Gly Val Val Ile Gly Glu Thr Thr Glu 25 Ile Gly Asp Asp Val Thr Ile Tyr His Gly Val Thr Leu Gly Gly Thr 40 Gly Lys Phe Lys Gly Lys Arg His Pro Thr Leu Gly Asn Arg Val Val 55 Val Gly Ala Gly Ala Lys Val Leu Gly Ala Ile Cys Val Gly Asp Asp 70 75 Val Arg Ile Gly Ala Asn Ala Val Val Leu Ser Asp Leu Pro Thr Gly 90 Ser Thr Ala Val Gly Ala Lys Ala Lys Thr Ile Thr Lys Asp Arg 100 105 110 INFORMATION FOR SEQ ID NO:1483: SEQUENCE CHARACTERISTICS: LENGTH: 377 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...377 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1483 Lys Gly Phe Leu Gly Val Lys Lys Val Ile Val Phe Ile Lys Lys Lys 1 5 10 Gly Glu Met Val Val Asn Ser Lys Val Gin Thr Leu Lys Val Phe Ser IPEAUS 18DE C 1996 1046 Lys Glu Glu Thr Lys Leu Tyr Ser 145 Asn His Ile Ile Asn 225 Gly Asn Cys Lys Gin 305 Val lle Ile Met Phe Ala Ile Val Tyr Ala Asn 130 Leu G1u Pro Ala Ile 210 Thr Tyr Ile Lys Thr 290 Arg Leu Met Ala Ser 370 Phe His Ile Gly Gly Leu 115 Glu Ser Lys Val Leu 195 Met Leu Ile Ala Met 275 Gin Ile Asp Asp His 355 Gin Ser Lys Tyr Phe Glu 100 Tyr Ile Lys Ile Leu 180 Ile Gly Leu Pro Phe 260 Ala Val Gly Glu Glu 340 Arg His Asn Leu Ser Ser Ala Arg Ala Thr Thr 165 Lys Gly Leu Thr Gin 245 Gly His Gly Ile Ala 325 lie Leu Lys Phe Phe Thr 70 Leu Arg Ile Tyr Ile 150 Leu Asn His Thr Ser 230 Asn Ser Ile Glu Ala 310 Thr Tyr Ser Asp Lys Gly 55 Leu Leu Met Leu Asn 135 Val Gin Phe Ser Tyr 215 Glu Ile Ala Tyr Gly 295 Arg Ser Gin Thr Asn 375 Ile 40 Glu Gin Ile Val Pro 120 Gin Glu Asn Asn Gly 200 Pro Asn Tyr Ile Asp 280 Gly Ala Ala Ile Ile 360 Leu 25 Thr Asn Val Leu Leu 105 Ser Leu Glu Ile Leu 185 Cys Lys Arg Leu Asp 265 Phe Ala Leu Leu Ala 345 Glu Gly Lys Ser Val Ala 90 Pro Val Ala Asp Ser 170 Thr Gly Ser Arg Phe 250 Glu Leu Lys Tyr Asp 330 Lys Arg Leu Arg Pro 75 Val 1 Thr Thr Thr Leu 155 Phe Ile Lys Gly Ser 235 Asp Lys Cys Leu Asp 315 Asn Asn Cys Lys Lys Arg Ala Ile Gly Asn 140 Val Ala Gin Ser Glu 220 Trp Gly Arg Glu Ser 300 Asn Glu Lys Glu Asp Asn Ala His Tyr Ser Tyr Ile Ser Met 110 Val Ile 125 Val Val Pro Leu Tyr Lys Lys Gly 190 Thr Leu 205 Ile Phe Arg Lys Thr Val Leu Ile 270 His Glu 285 Gly Gly Pro Glu Thr Glu Thr Leu 350 Val Ile 365 His Asp Ile Leu Tyr Ser Phe Asp Ser 175 Gin Ala Ile Lys Gly 255 Lys Gly Gin Ile Ser 335 Ile Ile Glu Thr Glu Phe Ala Tyr Lys Phe 160 Lys Lys Asp Asp Ile 240 Asp Val Leu Lys Leu 320 Lys Val Asp INFORMATION FOR SEQ ID NO:1484: SEQUENCE CHARACTERISTICS: LENGTH: 229 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...229 PCT/UIS 96/0912.2 1047 IPENU 18 DEC 1996 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1484 Ala Tyr Lys Lys Gly Giu Ile Met Ala Leu Glu Val Val Leu Trp Asp 1 5 10 Ph. Asp Gly Val Ile Ph. Asp Ser Met His Leu Lys Tyr Giu Gly Ph.
25 Lys Ala Leu Ph. Gin Lys His Gly Asn Asp Ser Lys Glu Gly Leu Lys 40 Gin Ph, Giu Val Tyr His Tyr Gin Ser Gly Gly Ile Ser Arg Asn Giu 55 Lys Ile Gin Tyr Ph. Tyr Asn Giu Ile Leu Lys Thr Pro Ile Ala Gin 70 75 Glu Giu Ile Asp Ala Leu Ala Leu Giu Ph. Gly Ala Ile Ile Giu Gin 90 Lys Leu Ph. Asp Arg Gly His Leu Asn Ser Giu Val Met Ala Ph, Ile 100 105 110 Asp Lys His Tyr Gin Asn Tyr Ile Ph. His Ile Ala Ser Ala Ala Leu 115 120 125 His Ser Glu Leu Gin Val Leu Cys Giu Ph. Leu Gly Ile Thr Lys Tyr 130 135 140 Ph, Lys Ser Val Giu Gly Ser Pro Pro Asp Lys Pro Lys Ile Ile Ala 145 150 155 160 Asn Ile Ile Gin Lys Tyr Ala Tyr Asp Pro Ser Arg Met Leu Met Ile 165 170 175 Gly Asp Ser Val Asn Asp Tyr Giu Ser Ala Lys Ala Asn Lys Val Ala 180 185 190 Ph, Leu Gly Tyr Asn Ser Lys Val Leu Lys Asn Leu Val Gly Gin Asp 195 200 205 Gly Tyr Gin Gly Lys Tyr Leu Giu Ser Ph. Lys Gly Phe Asp Leu Gin 210 215 220 Asn Ph. Ala Lys Giu 225- INFORMATION FOR SEQ ID NO:1485: SEQUENCE CHARACTERISTICS: LENGTH: 165 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL; YES (vi) ORIGINAL SOURCE: ORGANISM: Heiicobacter pylori (ix) FEATURE: NAME/KEY: misc...featur.
LOCATION .165 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1485 Asn Lys Ser Met Gin His Leu Val Leu Ile Gly Ph. Met Gly Ser Gly 1 5 10 Lys Ser Ser Leu Ala Gin Glu Leu Gly Leu Ala Leu Lys Leu Giu Val 25 Leu Asp Thr Asp Met Ile Ile Ser Glu Arg Val Gly Leu Sen Val Arg 40 Gly Ile Phe Glu Giu Leu Gly Giu Asp Asn Ph. Arg Met Ph. Giu Lys s0 55 Asn Leu Ile Asp Giu Leu Lys Thr Leu Lys Thr Pro His Ile Ile Ser 70 75 Thr Gly Gly Gly Ile Val Met His Glu Asn Leu Lys Gly Leu Gly Thr PCT/ 91 1048 90 Thr Phe Tyr Leu Lys Met Asp Phe GIu Thr Leu Ile Lys Arg Leu Asn 100 105 110 Gin Lys GIu Arg Glu Lys Arg Pro Leu Leu Asn Asn Leu Thr Gin Ala 115 120 125 Lys Giu Leu Phe Glu Lys Arg Gln Ala Leu Tyr Glu Lys Asn Ala Ser 130 135 140 Phe Ile Ile Asp Ala Arg Gly Gly Leu Asn Asn Ser Leu Lys Gln Val 145 150 155 160 Leu Gln Phe Ile Ala 165 INFORMATION FOR SEQ ID NO:1486: SEQUENCE CHARACTERISTICS: LENGTH: 325 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...325 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1486 Ile Phe Phe Lys Gly Leu Val Met Leu Ser Arg Asp Ile Val Gln Tyr 1 5 10 Ser Lys Ile Arg Thr Glu Leu Tyr Ala Tyr Leu Thr Tyr Leu Phe Ser 25 His Asn Ile Arg Asn His Leu Pro Glu Ile Thr Leu Asp Tyr Leu Asn 40 Arg Gln Ile Ser Lys Met Gln Ala Giu Ile Lys Met Ala Lys Ser Phe 55 Phe Val Leu Asp Ala Lys Gly Met Leu Met Leu Lys Pro Ser Gln Phe 70 75 Lys Glu Gin Gly His Lys Glu Gly Leu Leu Glu His Asp Leu Thr Glu 90 Gly Ile Glu Leu Glu Ser His Val Ser Phe Ser Asp Lys Tyr Tyr Phe 100 105 110 Tyr Gin Ala Val Asn Glu Lys Arg Cys Ile Leu Thr Asp Pro Tyr Pro 115 120 125 Ser Lys Lys Gly Asn His Leu Val Val Ser Ala Ser Tyr Pro Val Tyr 130 135 140 Asp Gln Asn Asn Asp Leu Ala Phe Val Val Cys Leu Gin Ile Pro Leu 145 150 155 160 Arg Val Ala Ile Glu Ile Ser Ser Pro Ser Lys Tyr Phe Lys Thr Phe 165 170 175 Ser Glu Gly Ser Met Val Met Tyr Phe Met Ile Ser Ile Met Leu Thr 180 185 190 Leu Val Ser Leu Leu Leu Phe Val Lys Cys Ile Ser Ser Phe Trp Thr 195 200 205 Ala Ile Val His Phe Ser Ser Phe Asp Ile Lys Glu Val Phe His Pro 210 215 220 Ile Val Leu Leu Thr Leu Ala Leu Ala Thr Phe Asp Leu Val Lys Ala 225 230 235 240 lie Phe Glu Glu Glu Val Leu Gly Lys Asn Ser Gly Asp Asn His His 2A 250 255 PCT/US 9 6 /091 2 2 IPEAN S 18DEC1996 1049 Ala Ile His Arg Thr Met Ile Arg Phe Leu Gly Ser Ile Ile Ile Ala 260 265 270 Leu Ala Ile Glu Ala Leu Met Leu Val Phe Lys Phe Ser Val Ser Glu 275 280 285 Pro Asp Lys Ile Thr Tyr Ala Val Tyr Leu Ala Ile Gly Val Ala Val 290 295 300 Leu Leu Ile Ser Leu Ala Ile Tyr Val Lys Phe Ala Tyr Ser Val Leu 305 310 315 320 Pro Lys Arg Glu Arg 325 INFORMATION FOR SEQ ID NO:1487: SEQUENCE CHARACTERISTICS: LENGTH: 188 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...188 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1487 Glu Ser Tyr Gin Thr Val Phe Thr Arg Gin Arg Tyr Tyr Gln Arg Leu 1 5 10 Phe Arg Arg Ala Val Cys Arg Asn Leu Arg Val Cys Glu Phe Thr Asn 25 Gin Asn Asn Lys Arg Gly Asp Cys Gin Arg Gin Gln Leu Phe Tyr Gly 40 Ala Tyr His Gly Glu Cys Leu Ser His Phe Arg Ile Ala Lys Thr His 55 Cys Gly Ala Ser Pro Phe Ile Val Ser Asp Phe Asn Phe Ile Gly Phe 70 75 Ile Val Pro Pro Ser Asn His Phe Ile Cys Gly Ser Gin Leu Lys Ser 90 Arg Pro Phe Arg Ala Ile Cys Leu Ala Arg Ile Ser Lys His Cys Gin 100 105 110 Ser Leu Phe Thr Leu Val Cys His Arg Val Phe Tyr Gly Val Pro Tyr 115 120 125 Phe Met Leu Gly Val Ile Glu Arg Tyr Tyr Phe Trp His Asp His Glu 130 135 140 Asn Pro Pro Ser Ile Gin Pro Ala Arg Tyr Arg Val Ser Gly Asn Cys 145 150 155 160 Asp Arg Val Cys Gly His Tyr Phe Asn Arg Phe Gly Tyr His Gly Ala 165 170 175 Phe Arg Arg Asn Gln Pro Gly Leu Arg Tyr Asn Leu 180 185 INFORMATION FOR SEQ ID NO:1488: SEQUENCE CHARACTERISTICS: LENGTH: 444 amino acids TYPE: amino acid TOPOLOGY: linear PCTUS 9 6 /09122 !PEANUS 180E01996 1050 (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .444 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1488 Gly Val Lou Arg Phe Se Ile Phe Phe 1 Ile Gin Val1 Ile Asn Asn Leu Val1 Ile 145 Giu Ser Phe Leu Gly 225 Phe Arg Ph.
Asp Ile 305 Asp Ile Asp Gin Giu 385 Cys Thr Ile Thr so Giu Leu Ile Leu Ser 130 Leu Leu Cys Asp Phe 210 Lys Ser Ile Leu Giu 290 Giu Asn Gly Phe Aia 370 Ala Ph.
Lou Sen Thr Asp Giu Trp Lys 115 Tyr Ph.
Arg Lys Asn 195 Leu Ile Ser Glu Met 275 Asp Ala Ala Asn Glu 355 His Met Thr Ph.
His Ile Tyr Lys Tyr 100 Lys Arg Leu Ser Se r 180 Cys Arg Lou Ile Gin 260 Ser Lys Asp Ile Asn 340 Lys Gly Gly Ile Ser Giu Asn Leu Val1 Ala Asp Asnr Phe Gin 165 Lys Ile Ser Sen Ph.
245 Leu Asp Lys Ph.
Lys 325 Leu Tyr Phe Leu His 405 Phe As n Giu Tyr 70 Leu Giu Giu Tyr Leu 150 Val1 Gin Gin Ile Ser 230 Asp Ala Leu Ser Giu 310 Tyr Val1 Leu Gly Asn 390 Asp Giy Tyr Ile 55 Lys Ala Val1 His Phe 135 Ph.
Lys Lys Lys Met 215 Met His Ser Ile Pro 295 Lou Ser Val1 Gin Leu 375 Leu Cys Ala Gin 40 Leu Ile Lys Phe Phe 120 Leu Val1 Arg Asp Ile 200 His Leu Leu Lys Asp 280 Ile Ph.
Asp Ser Pro 360 Gly Ser Val1 Phe 25 Asn Asn Gly Arg Lys 105 Val1 Ala Leu Ph.
Giu 185 Asn Glu Lys Asn Asn 265 Lys His Ala Asp Asn 345 Tyr Met Tyr Ph.
Val Val Ala Tyr Tyr Phe Met Arg His Tyr Ser Asp Arg Giu Thn 75 His Gin Lou Ser Asp Met Tyr Lys Asp 125 Thn Val Gly 140 Ser Leu Leu 155 Gin Gly Asp Gly Asp Lou Met Asn Giu 205 Arg Thr Pro 220 Giu Lou Sor 235 Lou Ile Giu Gly Ser Asn Giu Lys Met 285 Ser Ser Ser 300 Ala Lou Lys 315 Gin Val Phe Ser Lys Pro Lys Ser Sen 365 Ile Ile Lys 380 Tyr Ser Asn 395 Ser Ph. Tyr Leu Val1 Tyr Tyr Thr His Val1 110 Leu Leu Pro Lys Ala 190 Ser Ile Cys Gin Lys 270 Lou Asn Asn Lou Lou 350 Asn Asn G ly Asp Phe Ser Gin Arg Ile His Ph.
His Leu Leu Sen 175 Asn Arg Thr Lys Ph.
255 Giu Lou Met Asp 335 Lys Pro Ala Arg Lou 415 Met Sen Ph.
Ala Giu Arg Ile Sor Leu Arg 160 Val1 Giu Val1 Lys Arg 240 Ala Lys Ile Ile Ile 320 Ph.
Giu Sor Lou Ile 400 Glu A PCTUS 09122 I PEWS EC 199B 1052.
Ala Asp Asn Glu Giu Lou Pro Pro Pro Arg Lys Phe Glu Arg Gly Glu 420 425 430 Gly Asn Glu Gly Asn Arg Lys Ser Gin Leu Trp Gly 435 440 INFORMATION FOR SEQ ID NO:1489: SEQUENCE CHARACTERISTICS: LENGTH: 330 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .330 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1489 1Arg Lys Thr Lys Arg Giu Asn Met Phe Ser As n Lys Pro Val1 Ala Lys Tyr Asn 145 Giu Val Pro Phe 225 Glu Ala Leu Gln Ser Giu Asp Phe Asn Glu so Leu Leu Leu Leu Lou Asn Arg Phe 115 Thr Asp 130 Asp Lys Ser Gly Leu Ser Ile Met 195 Arg Asp 210 Gin Met Asp Giu Tyr Lou Ala Lou 275 Lys His As n Ile Ile Lys Phe Lys 100 Lys His Thr Val Lou 180 Sen Val Asp Lys Asp 260 Tyr Asn
S
Lou Ala Ser Giu Gly Asp Asp Gly Leu Asp 165 Arg Tyr Ala Gin 245 Ile Asn Lou Arg Pro Sen Cys 70 Ile His Lou His Lys 150 Ile Lys Ser Asn Ala 230 Gly Val1 Val1 Ile Ala Met Val 25 Leu Phe Val 40 Met Pro Gly 55 Giu Giu Lou Pro Lys His Ile Val Ala 105 Ile Val Ile 120' Cys Gly Ile 135 Ile Lou Asn Lou Ala Pro Ala Lou Asp 185 Thr Lys Phe 200 Sen Pro Pro 215 Asn Gin Lys Ala Asp Ile Lys Glu Ile 265 Sen Gly Giu 280 Asn Tyr Glu 295 Gly Ala Asp Lys Arg Ile Val1 Val1 Lys 90 Lys Ala Lou Lou Ser 170 Lys Ala Ser Giu Lou 250 Arg Tyr Sen Met Glu G iu Tyr Gly 75 Asp Ala Asp Glu Gin Asn Ala Ser Ph.
Ala 235 Met Asp Ala ValI Ile Thr Sen Gin Lou Ala Thr Lou Asn 140 Gly Met Gly Sen Gly 220 *Lou *Val His Met *Leu 300 Ile Arg Asp Met Gly Thr Arg Cys 125 Ala Lou Met 205 Asp Lou Lys Thn Lou 285 Lou Sor Arg Lou Ang Ang Lou Ang 30 Ser Ser Ile 31y Glu 110 Ph.
Ser Ile Asp Phe 190 Tyr Arg Giu Pro Lou 270 Lys Giu Asn Gly Ile Lys Ser Ile Cys Val1 Lou Gly 2.75 His Gly Lys Sor Ala 255 Leu Lou Thn His I le Ioe Glu Ala Hiis Lys Glu Sen Ala 160 Asri Thr Pro Son Lou 240 Lou Pro Ala Met Ala 290 Thn Cys Phe Lys Arg Ala PICT/& 96092 IPENU 18 DEC 996 1052 315 305 310 Lys Glu Val Ala Asn Leu Leu Gin Arg Asn 325 330 INFORMATION FOR SEQ ID NO:1490: SEQUENCE CHARACTERISTICS: LENGTH: 362 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .362 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1490 Ser Ala Gly Arg Ile Leu Ala Glu Asp Ile Ile
I
Pro Asp Asp Thr Cys Lys Ser Lou, Lys 145 Asn Asn Asp Ile Asp 225 Lou Ile Val Lys Asn 305 Lys Leu Val1 so Gly Met Ile Val Ile 130 Ile Ala Met Lys Leu 210 Ala Lys Ile Leu Lou 290 Ph.
Gly Sen Ala Lou His Lou 115 Ala Ala Lou Lou Asn 195 Ser Lou Pro Gly Ile 275 Lys Asn Gin Ala Met Glu Ala 100 Val Sen Lou Glu Lys 180 Leu Ser Lys Gly Lou 260 Lou Pro
S
Gin Lys Leu Val1 Ser Asn Pro Gin Ph.
Cys 165 Asn Gin Ala Giu Lys 245 Pro Pro Phe Ser Thn Giu Pro 70 His Ile Lys Gly Ser 150 Gin Tyr Lou Gly Arg 230 Pro Gly Lou Lys Ala Gin Val 55 Lys Lys Ang Asn Ph.
135 Ser Val Asn Lys Val 215 As n Vat As n Lou Ala Met Val1 40 Lys Gly Asp Gin Thr 120 Lys Gly Tyr Thr Ile 200 Sen Ala Thr Pro Glu 283 Gin Asp 25 Ile Giu Ile Ph.
Lys 105 Arg Giu Asp Asp His 185 Lou Vat Lou Lou Lou 265 Ang Ile 10 Gly Gin Asn Glu Ala 90 Gly Lou Ile Giu Val 170 Ph.
Giu Gly Ph.
Ala 250 Ser Lou As n Tyr His Giu Thn 75 Lou Giu Asn Lys Lou 155 Asn Lou Lou Asp Tyr 235 Gin Cys Ser Ala Tyr 315 Cys Gly Ile Cys Ile Ala Asn Tyr Ala 140 Val Ser Gly Gin Lys 220 Tyr Lou Lou Lou Pro 300 Sen Val Ph.
Ph.
Val1 Val Pro Ala G ly 125 Ph.
Pro Vat Val Gly 205 Asp Giu Asn Lou Asn 285 Lou Asn His Lys Ala Lys Pro Lys Ser 110 His Arg Leu Gly Lou 190 Tyr Ph.
Lys Gin Val1 270 Lys Lys His Ala Met Gly 'Ile Ile Asp Lou Ile Lys Gly Val 17S Lys Asp Ph.
Val Ser 255 Lou Asp Lou Gin Lou Gin Asp Met Giu Ph.
Asn Ala Lou Gin 160 Ph.
Asp Vat Lys Asn 240 Ile Arg Ph.
Asn Phe 320 Lys Arg Thr His Lou Ile Lou Gly Asn 310 Av.
PCT, 9 6 /0912 2 IPEAUS uDtC 1996 1053 Ile Pro Tyr Asn Asn Arg Tyr Glu Ser Gly Ala Ile Gin Ala Leu Ala 325 330 335 Gin Val Asp Ser Ile Ala Leu Ile Asp Glu Gly Val Gly Leu Val Gin 340 345 350 Gly Glu Ile Glu Ile Leu Arg Phe Glu Asn 355 360 INFORMATION FOR SEQ ID NO:1491: SEQUENCE CHARACTERISTICS: LENGTH: 211 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...211 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1491 Gly Asn Tyr Gly Leu Glu Ile Arg Phe Lys Glu Met Ala Val Leu Lys 1 5 10 Lys Met Ile Gly Leu Val Ala Val Leu Ser Val Leu Leu Ala Arg Asp 25 Asn Pro Phe Glu Pro Glu Ile Asn Ser Lys Asn Leu Gin Gly Gly Phe 40 Ser Gly Ile Tyr Asp Asp Tyr Leu Lys Glu Ile His Val Asp Leu Pro 55 Thr Ser Ala Arg Ile Leu Lys Lys Ile Thr Leu Thr Tyr Gin Asp Ile 70 75 Asp Gly Ser Ile His Ser Lys Val Val Gly lie Asp Lys Ser Ile Asp 90 Trp His Tyr Pro Leu Lys Leu Ser Gln His Thr Leu Asn Gin Asp Ala 100 105 110 Phe Glu Lys Arg Tyr Gln Ile Gin Asp Phe Asp Phe Leu Met Ala Asn 115 120 125 Asn Thr Met Ile Leu Arg Ser Pro Tyr Lys Ile Leu Arg Ser Phe Val 130 135 140 Leu Val Asn Pro Tyr Arg Ile Val Leu Asp Thr Gin Lys Gly Pro Leu 145 150 155 160 Asp Ile Tyr Gln Asn Met Asp Leu Asn Gin Lys Phe Phe Ser His Ile 165 170 175 Lys Val Gly Thr His Lys Asp Tyr Tyr Arg Ile Thr Leu Ile Leu Asp 180 185 190 Gly Lys Tyr Arg Tyr Leu Leu Glu Glu Lys Asn Gly Ala Tyr Glu Leu 195 200 205 Lys Leu Lys 210 INFORMATION FOR SEQ ID NO:1492: SEQUENCE CHARACTERISTICS: LENGTH: 352 amino acids TYPE: amino acid TOPOLOGY: linear PCTUS 96IO91aa iPEN/US P5D0C1996 1054 (ii) MOL ECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1 .352 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1492 Lys 1 Giu Ser Leu Lys Leu Thr Ile Thr dly 145 Ser Sen Thr Pro Ala 225 Leu Asp Leu Thr Leu 305 Leu Gly Ala Val Ala Thr Pro His His Thr Pro Lou Trp Ser Giu Val1 Val1 Ala Ser Tyr Pro 130 Gly Val1 Gly Phe Met 210 His Gly Pro Asp Ile 290 Giu Lys Leu Ph.
Leu Lys Ile As n His Tyr 115 Gin Ph.
Ser Asp Ile 195 Val1 Ser Ala Lys Ph.
275 Phe As n Val1 Leu Lys Asp Gly Asp Met Tyr 100 Asn Leu Lys Tyr Leu 180 G ly Leu Asp Ile Tyr 260 Ser Ser Leu Thr Val 340 5 Glu Tyr GJly Ser Glu Cys Glu Ser Asp Ilie 165 Lys Met Gly Gly Lys 245 Lys Gin Giu Sen Thr 325 Ala Val1 Ala Thr Ala Ile Ala His Glu 150 Giu Ph.
Gly Gly Asp 230 Gly Asn Ser Ile Gin 310 Met Lou Tyr Se r 55 Tyr Leu Ala Lou Thr 135 Ser G ly Phe Ph.
Val 215 Ala Gly Ala Ile Pro 295 Leu Giu Asp Ile 40 Arg Thr Lys Pro Asp 120 Lys Ser Sen Thr Asp 200 Val Leu Asp Ser Gly 280 Lys Lou Lys Ph.
25 Gin Gin Ile Ser Tyr 10s Ang Thr Ala Lys Pro 185 Thr Lou Leu Ile Ser 265 Phe Ile Gly Met Ser 345 Lys Arg Giu Thr Leu 90 Lou Giu Leu Ile Asp 170 Phe His Asp His Gly 250 Lys G iu Thr Lou Gly 330 Met Glu His Sen Ser 75 Ph.
Pro Ala Gin Lou 155 Lou Phe Ala Cys Ala 235 Glu G iu Lou Pro Glu 315 Phe Arg Val1 Tyr Val1 E0 Asp Lou Cys Ile Sen 140 Gin His Asn Ph.
Glu 220 Val1 Trp Lou Lou Tyr 300 Lys Ile Tyr Lou Ile Pro Arg Val1 Thr Tyr Lys 125 Ala Ala Lys Pro Ile 205 Phe Ile Phe Lou Glu 285 Lys Ser Gly Lys Son Lou Lys Asn Ala Lou Asp 110 Lou Lou Ph.
Lou Ala 190 Lys G ly Asp Pro Lys 270 Met Pro Gin Lys Gir 350 Val1 Va. 1 Ile Ala Arg Gin Thr Ile As n Pro Thr 175 Lys Asp Leu Ala Asp 255 Ile Gly Ala Ile Gin 335 Lys Tyr Val Lys Leu Gly Gin Ala Gin Gin Asn 160 Thn Asp Lys Lys Ile 240 Asn Val1 Ala Ile Ser 320 Giu Leu Gin Ala His Val INFORMATION FOR SEQ ID NO:1493: SEQUENCE CHARACTERISTICS: LENGTH: 205 amino acids TYPE: amino acid TOPOLOGY: linear PCT/US 9 6 091 2 iPEA/US 1 DEC 1996 1055 (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...205 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1493 Cys Leu Gly Met Cys Phe Ile Leu Lys Pro Phe Leu Ser Cys Leu Lys 1 5 10 Trp Ala Asn Pro Ser Leu Lys Pro Leu Ser Asn Ala Val Leu Arg Leu 25 Ser Arg Gly Glu Ile Glu Asp Val Phe Val Gly Glu Cys Phe Asn Ser 40 Asp Lys Gln Lys Tyr Trp Arg Ile Leu Glu Asp Lys Thr Ala His Phe 55 Ile Glu Ala Ser Leu Lys Ser Met Ala Ile Leu Leu Asn Lys Asp Ala 70 75 Lys Met Tyr Ala Asp Phe Gly Leu His Phe Gly Met Ala Phe Gin Ile 90 Ile Asp Asp Leu Leu Asp Ile Thr Gin Asp Ala Asn Thr Leu Gly Lys 100 105 110 Pro Asn Phe Ser Asp Phe Lys Glu Gly Lys Thr Thr Leu Pro Tyr Leu 115 120 125 Leu Leu Tyr Glu Lys Leu Asn Gin His Glu Gin Gly Leu Leu Ile Ser 130 135 140 Tyr Phe Lys Gln Asp Ser His Giu Ile Ile Glu Trp Thr Lys Glu Lys 145 150 155 160 Phe Lys Gin His Gly Ile Ile Glu Glu Thr Leu Lys Ile Ala Gin Val 165 170 175 Tyr Ser Lys Lys Ala Leu Glu Ala Ile Lys Gly Glu Asn Asn Leu Ile 180 185 190 Leu Glu Lys Leu Ala Gin Asp Val Ile Tyr Arg Thr Phe 195 200 205 INFORMATION FOR SEQ ID NO:1494: SEQUENCE CHARACTERISTICS: LENGTH: 131 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...131 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1494 Lys Lys Val Lys Met Asn Ile Lys Ile Leu Lys Ile Leu Val Gly Gly 1 5 10 Leu Phe Phe Leu Ser Leu Asn Ala His Leu Trp Gly Lys Gin Asp Asn '?CT1J3," 96 091226 IPENUS 16DEC 19 1056 25 Ser Phe Leu Gly Ile Gly Giu Arg Ala Tyr Lys Ser Gly Asn Tyr Ser 40 Lys Ala Ala Ser Tyr Phe Lys Lys Ala Cys Asn Asp Gly Val Ser Giu 55 Gly Cys Thr Gin Leu Gly Ile Ile Tyr Glu Asn Gly Gin Gly Thr Arg 70 75 Ile Asp Tyr Lys Lys Ala Leu Giu Tyr Tyr Lys Thr Ala Cys Gin Ala 90 Asp Asp Az-g Giu Gly Cys Phe Gly Leu Gly Gly Leu T'yr Asp Glu Gly 100 10s 110 Leu Gly Thr Ala Gin Asn Tyr Gin Giu Ala Ile Asp Ala Tyr Ala Arg 115 120 125 His Ala Phe 130 INFORMATION FOR SEQ ID NO:1495: SEQUENCE CHARACTERISTICS: LENGTH: 239 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc feature LOCATION .239 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1495 Ser Set Lys Thr Ala Phe Arg Ala Lys Gin Ile Ile Thr Ala Thr Asp 1 S 10 Ile Ser Ala Gin Lys Arg Gin Giu Arg Lou Ala Ser Met Gly Lys Ile 25 Sen Ala His Lou Ala His Giu Ile Arg Asn Pro Val Gly Ser Ile Son 40 Leu Leu Ala Set Val Lou Lou Lys His Ala Asn. Giu Lys Thr Lys Pro 55 Ile Val Val Glu Leu Gin Lys Ala Leu Trp Ang Vai Giu Ag Ile Ile 70 75 Lys Ala Thr Leu Leu Ph. Set Lys Gly Ile Gin Ala Asn Arg Thn Lys 90 Gin Sen Lou Lys Thr Lou Giu Sen Asp Lou Lys Giu Ala Lou Asri Cys 100 los 110 Tyjr Thr Tyr Ser Lys Asp. Ile Asp Phe Lou Phe Asri Phe Sor Asp Glu 115 120 125 Glu Giy Phe Phe Asp Phe Asp Lou Met Gly Ile Val Lou Gin Asn Ph.
130 135 140 Lou Tyr Asn Ala Ile Asp Ala Ile Glu Ala Lou Giu Giu Ser Giu Gin 145 150 155 160 Gly Gin Val Lys Ile Giu Ala Phe Ile Gin Asri Giu Phe Ile Val Phe 165 170 175 Thn Ile Ile Asp Asn Gly Lys Giu Val Glu Asn Lys Son Ala Lou Phe 180 185 190 Giu Pro Phe Glu Thn Thr Lys Lou Lys Gly Asn Gly Lou Gly Lou Ala 195 200 205 Leu Sen Lou Gin Val Val Lys Ala His Giu Gly Sen Ile Ala Lou Lou 210 215 220 PCT/US 9 6 0912 22 IPEA/US 18 DEC1996 1057 Glu Asn Gin Glu Lys Thr Phe Glu Ile Lys Ile Leu Asn Ala Ser 225 230 235 INFORMATION FOR SEQ ID NO:1496: SEQUENCE CHARACTERISTICS: LENGTH: 155 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...155 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1496 Lys Pro Lys Thr Ile Leu Lys Lys Gly Leu Leu Met Lys Thr Phe Glu 1 5 10 Ile Leu Lys His Leu Gln Ala Asp Ala Ile Val Leu Phe Met Lys Val 25 His Asn Phe His Trp Asn Val Lys Gly Thr Asp Phe Phe Asn Val His 40 Lys Ala Thr Glu Glu Ile Tyr Glu Gly Phe Ala Asp Met Phe Asp Asp 55 Leu Ala Glu Arg Ile Val Gin Leu Gly His His Pro Leu Val Thr Leu 70 75 Ser Glu Ala Ile Lys Leu Thr Arg Val Lys Glu Glu Thr Lys Thr Ser 90 Phe His Ser Lys Asp Ile Phe Lys Glu Ile Leu Glu Asp Tyr Lys His 100 105 110 Leu GIu Lys Glu Phe Lys Glu Leu Ser Asn Thr Ala Glu Lys Glu Gly 115 120 125 Asp Lys Val Thr Val Thr Tyr Ala Asp Asp Gln Leu Ala Lys Leu Gin 130 135 140 Lys Ser Ile Trp Met Leu Glu Ala His Leu Ala 145 150 155 INFORMATION FOR SEQ ID NO:1497: SEQUENCE CHARACTERISTICS: LENGTH: 131 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...131 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1497 aT
POUS
IPE~jbS 1058 Gly Ala Ser Leu Leu Asp Ala Ser Ala Ile Ser Lys Leu Cys Val1 Leu Lys Pro 130 Cys *Met Trp Ile Ile Gly Asp Glu Ala Ile Ile Asp Ph. Gly 100 Ala Phe 115 Leu Arg Glu Met 40 Ala Ile Met Ala Ser 120 Leu Ser Leu Ile Gin Arg Val1 105 Lys Gin Asp Leu Lys Leu Pro Asp Ser 125 0~/912a2 Ile Phe Ala Asn Asp As n Tyr Gin INFORMATION FOR SEQ ID NO:1498: SEQUENCE CHARACTERISTICS: LENGTH: 577 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Heiicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .577 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:i498 1Cys Met Leu Phe Ser Lys Leu Phe Ala Pro Thr Leu Lys Giu Lys Pro Lys His Trp Phe O ha Leu Ang 145 dly Asp Leu Val1 so Giy Giu Lys Asn Pro 130 Pro Tyr Ala Gin Leu Ala Lys Asp Ile Val1 Ang Ser Leu Gly Lys Asn Gly Lys Glu Leu Gly His Lys Ser Ile Ile 70 Arg Asp Ile Tyr Leu iso 0 iu Ser Gly Glu 55u Leu Asn Ala Gin 135 Val1 Asp Pro Ile 40 Asn Met Asp Asp Ala 120 Ile Arg Ala Lys His Tyr Asn Val Thr Sen Phe Lys Tyr 90 Ph. Val 105 Asn Phe His Thr Ala Arg Giu Sen 170 Ile Leu 185 Pro Ph.
His Val1 75 Gly Leu Ile Lys Glu 155 Leu Ser Gly Leu Lys Val Lys Ser Lys Ph.
140 Ph.
Asp Asp Asn Pro Arg Leu Giu Pro Sen 125 Ang Ile Lys Leu dly Leu Met Ala Leu Thr 110 Tyr Asp Met Giu Gly 190 Pro 0 ly Ala Gin Ser Leu Leu Lys Glu Lys Ile 175 Leu Pro His Lys Giu Leu Val Giu Gin Ile Asp 160 Leu Asp 165 Asn Thr Gin Sen Ala Tyr Lys Giu 180 <D3 0.,1 r~ti^^°9b 1059 Phe Arg Cys 225 Lys Thr Glu Asp Glu 305 Leu Ile Ile Ala Glu 385 Cys Gly Ser Tyr Ser 465 Val Ala Leu Leu Ser 545 Ile Glu Arg Glu 210 Gln Arg Pro Pro Lys 290 Glu Glu Ala Ile Asn 370 Asn Pro His Phe Gly 450 Asp Val Phe Asp Ile 530 Lys Lys Ile Val 195 Phe Val Asn Cys Thr Glu Asn Thr 260 Tyr Phe 275 Glu Thr Thr Lys Leu Arg Gly Phe 340 Phe Asp 355 Glu Lys Leu Val Asn Cys Ile Phe 420 Leu Asp 435 Ile Gly Asp Leu Ile Val Glu Val 500 Asp Arg 515 Gly Glu Glu Phe i Asp Ile Glu Ala Val Leu Asp Tyr 230 Pro Leu 245 Thr Ser Val Leu Leu Ala Ala Leu 310 Glu Ala 325 Ile Gly Glu Asp Asp Phe Tyr Ala 390 Gin Gly 405 Lys Leu Lys Asn Ile Ser Gly Cys 470 Val Ser 485 Tyr Glu Asp Ala Arg Leu Glu Cys 550 i Glu Leu 565 Asp Thr 215 Ala Met Ala Lys Cys 295 Asn Asn Pro Leu His 375 Asp Ala Gly Gly Arg 455 Val Asn Arg Arg Ala 535 Ile Ser 200 Glu Ala Ser Pro Ala 280 Phe Thr Glu Tyr Lys 360 Ala Ile Leu Gln Lys 440 Leu Trp Leu Leu Phe 520 Leu Lys Gly Cys Asn Pro Ser 265 Leu Phe Leu Glu Gly 345 Glu Val Val Lys Ser 425 Glu Leu Thr Lys Leu 505 Gly Ile Arg Ala Gly lie Ser 250 Val Val Val Asn Asp 330 Leu Gly Gly Gin Tyr 410 Tyr Arg Ser Lys Asp 490 Gin Ala Val Ala Ile 570 Ile ;lu Glu 235 Ala Ala Asn Arg Leu 315 Leu Lys Asp Val Val 395 His Ala Phe Val Asn 475 Glu Lys Lys Gly Asr Gly Asp 220 Ile Leu Glu Lys Gly 300 Leu Asn Lys Cys Asp 380 Lys Lys Lys Phe Ile 460 Thr Ala.
Gly Met Lys 540 i Leu Gly 205 Thr Ala Ala Phe Val 285 Asp Gly Lys His Leu 365 Leu Glu Ser Ser Glu 445 Leu Ala Gin Val Arg 525 Gin Glu Ser Ile Lys Lys Phe 270 Ile Asp Ala Ala Val 350 Ile Lys Ser Leu Leu 430 Met Glu Pro Lys Asp 510 Asp Thi Lys Lys Val Arg Phe 255 Lys His Asn Asn Gly 335 Cys Val Gly Asp Glu 415 Lys Gly Gin Phe Lys 495 Ala Phe Leu.
Gir Ser Val Ser 240 Pro Thr Lys Leu Ala 320 Leu Tyr Gly Phe Cys 400 Val Ala Cys Lys Asp 480 Leu Leu Glu Glu i Thr 560 555 Leu Giu Met Leu Glu Glu Lys Ala Ser 575 INFORMATION FOR SEQ ID NO:1499: SEQUENCE CHARACTERISTICS: LENGTH: 184 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori PCT/US 96/0912 2 1060 PEMUS 1 DEC 1996 (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...184 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1499 Ile Arg Glu Pro Gin Val Ala Ile Met Thr Ala Met Met Arg Tyr Phe 1 5 10 His Ile Tyr Ala Thr Thr Phe Phe Phe Pro Leu Ala Leu Leu Phe Ala 25 Val Ser Gly Leu Ser Leu Leu Phe Lys Ala Arg Gln Asp Thr Gly Ala 40 Lys Ile Lys Glu Trp Val Leu Glu Lys Ser Leu Lys Lys Glu Glu Arg 55 Leu Asp Phe Leu Lys Gly Phe Ile Lys Glu Asn His Ile Ala Met Pro 70 75 Lys Lys Ile Glu Pro Arg Glu Tyr Arg Gly Ala Leu Val Ile Gly Thr 90 Pro Leu Tyr Glu Ile Asn Leu Glu Thr Lys Gly Thr Gin Thr Lys Ile 100 105 110 Lys Thr Ile Glu Arg Gly Phe Leu Gly Ala Leu Ile Met Leu His Lys 115 120 125 Ala Lys Val Gly Ile Val Phe Gin Ala Leu Leu Gly Ile Phe Cys Val 130 135 140 Phe Leu Leu Leu Phe Tyr Leu Ser Ala Phe Leu Met Val Ala Phe Lys 145 150 155 160 Asp Thr Lys Arg Met Phe Ile Ser Val Leu Ile Gly Ser Val Val Phe 165 170 175 Phe Gly Ala Ile Tyr Trp Ser Leu 180 INFORMATION FOR SEQ ID NO:1500: SEQUENCE CHARACTERISTICS: LENGTH: 90 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION 1...90 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1500 Leu Ile Lys Ser Lys Ser Lys Lys Trp Leu Leu Val Gly Glu Gly Ala 1 5 10 Asn Ser Glu Ile Phe Glu Ala Ser Met Gin Ser Leu Leu Lys Thr Asp 25 Gly Val Tyr Ser Asn His Lys Pro lie Tyr Gin Glu Phe Tyr Glu Leu 40 Asn Ser His Asn Gly Leu Tyr Tyr Gin Pro Asn Val Phe Phe Ala Tyr 55 Glu Ser Cys Ala Leu Gly Phe Arg Lys Gly Gly Leu Ile Leu Asp Asn 70 75 Phe Ser Lys Phe Val Ser His Arg Leu Gin riA/u, 9 6 0912 IPEAJUS 18 DEC 1996 1061 INFORMATION FOR SEQ ID NO:1501: SEQUENCE CHARACTERISTICS: LENGTH: 283 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...283 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1501 Met Leu Glu Ser Val Asn Val Lys Ile Ser Ala Asp Asp Ile 1 Lys Arg Lys Asp Ser Arg Leu Asn Ile 145 Leu Val His Glu Ser 225 Thr Lys Ser Asn Gin Ser Gly Ser Glu Lys Lys 130 Gin Val Asp Pro Pro 210 Leu Ile Gly Ala Val Gly Ile Asn Asn Val Asn 115 Val Ile Gin Glu Ile 195 Leu Asp Ala Met Lys 275 Ala Asp Gin lie Leu Ser 100 Pro Phe Thr Glu Lys 180 Val Asn Thr Gly Val 260 Trp 5 Ala Lys Gly Tyr Leu Tyr Asn Gly Arg Ile 165 Ser Val Asp Ala Val 245 Ser Arg Val 1 Ile Gly Ala 70 Ser Asp Phe Asn Pro 150 Pro Gly Thr Ser His 230 Val Ile Tyr Met Asp Thr 55 Leu Ala Leu Lys Lys 135 Glu Ile Thr Ser Lys 215 Asn Lys Leu Tyr lie Ile 40 Leu Ala Asn Phe Asn 120 Val Arg Tyr Ile Gin 200 Asn Thr Ala Gin Asp 280 Thr 25 His Val Gin Ile His 105 Ala Ala Leu Tyr Val 185 Asp Met Leu Leu Ala 265 Lys 10 Ala Ile Met Gly Ile 90 Lys Ile Ile Ser Arg 170 Ser Ile Gin Ser Gin 250 Leu Gin Ser Ser Thr Ala 75 Asn Asn Gin Ala Met 155 Ala Gly Thr Asp Ser 235 Lys Lys Gin Leu Ser Pro Ile Gly Ala Val Leu 140 Val Lys Val Leu Leu 220 Asn Ile Lys Pro Ile Leu Ile Ala Met Gin 125 Asp Glu Asn Asp Lys 205 Asp Gly Gly Ser Pro Gly Asn Ser Thr Thr 110 Asn Pro Phe Lys Ile 190 Ile Asn Lys Val Gly 270 Lys Ser Phe Ala Asp Ala Ala Val Gly Asn Ile Glu Leu Ser Thr Leu Lys Thr Leu Ala 160 Ile Ile 175 Ile Val Thr Lys Asn Met Asn Ile 240 Ser Ala 255 Ala Ile INFORMATION FOR SEQ ID NO:1502: SEQUENCE CHARACTERISTICS: LENGTH: 222 amino acids TYPE: amino acid PCT/UL 96/U 9 i 1062 IPEANS i o 6 .ui996 TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...222 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1502 Thr Gly His Gly Arg Leu Gly Trp Ile Leu Asn Pro Lys Lys Ala Lys 1 5 10 Phe Ile Ala Leu Lys Gln Ala Trp Ile Tyr Glu Arg Met Leu Ser Phe 25 Ile Ser Ala Phe Asp Lys Arg Gly Val Ser Ile Arg Leu Leu Thr Ala 40 Leu Leu Leu Leu Phe Ser Leu Gly Leu Ala Lys Asp Leu Glu Ile Gin 55 Thr Phe Val Ala Lys Tyr Leu Ser Lys Asn Gin Lys Ile Gin Ala Leu 70 75 Gin Glu Gin Ile Asp Ala Leu Asp Ser Gin Glu Lys Val Val Ser Lys 90 Trp Asp Asn Pro Ile Leu Tyr Leu Gly Tyr Asn Asn Ala Asn Val Ser 100 105 110 Asp Phe Phe Arg Leu Asp Ser Thr Leu Met Gin Asn Met Ser Leu Gly 115 120 125 Leu Ser Gin Lys Val Asp Leu Asn Gly Lys Lys Leu Thr Gin Ser Lys 130 135 140 Met Ile Asn Leu Glu Lys Gln Lys Lys Ile Leu Glu Leu Lys Lys Thr 145 150 155 160 Lys Gln Gln Leu Val Ile Asn Leu Met Ile Asn Gly Ile Glu Asn Tyr 165 170 175 Lys Asn Gln Gin Glu Ile Glu Leu Leu Asn Thr Ala Ile Lys Asn Leu 180 185 190 Glu Asn Thr Leu Tyr Gin Ala Asn His Ser Ser Ser Pro Asp Leu Ile 195 200 205 Ala Ile Ala Lys Leu Glu Ile Leu Lys Ser Gln Leu Glu Ile 210 215 220 INFORMATION FOR SEQ ID NO:1503: SEQUENCE CHARACTERISTICS: LENGTH: 347 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...347 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1503 I PENS L Lj' 9 9 1063 Ile Val Phe His Gin Giy Ser Leo Ser Val 1 5 Arg Leu Asn Met Pro Aia Met Leu Giy 145 Val Leu Pro Phe Ser 225 Thr Ty~r Phe Gly Gin 305 Val Val Ile Phe Asp Phe Thr Phe Asp G iy 130 Tyr Leu Val1 Met Trp 210 Gin Lys His Leu Phe 290 G ly Aia Arg Leu Ile Arg Lys Asp Ile Leu 115 Thr Arg Ile Asp Leu 195 Ile Val1 Ala Val1 Met 275 G ly Lys Ilie Asp Ser Ala Pro Asn Tyr Ile 100 Asp Asp Val1 Gly Leo 180 Phe Ile Val1 Ala Leo 260 Ala Met Asp 5cr Ala 340 Phe Leu Leu Asn His Ser Asp Ser Val1 165 Val1 Leu Leu Arg Arg 245 Pro Ala Pro Asn Leu 325 Phe Lys Leo Phe Ala Asp Ala Pro Gin Leo 150 Ser G ly Leu Phe Thr 230 Ala As n Ser Ile Leu 310 Leu Asn Lys Ala Ile 55 Glu Pro Leu Ala Ala 135 Val1 Leu Gin Ile Leu 215 Glu Leu Ala Ile Gly 295 Thr Leu Ala Asn Leu 40 Tyr Val Tyr Ile Pro 120 Arg Phe Gly Arg Val1 200 Val1 Phe Gly Leu Ser 280 Ser Thr Scr Asn Lys 25 Ser Lys Glu Val Pro 105 Thr Asp G ly Ala Leo 185 Ile Leu Leo Val Val 265 Thr Ala Pro Val Met 345 Arg Leu Asp Phe Gin 90 Tyr Pro Val1 Ile Phe 170 Ser Ser Leu Lys Asn 250 Ala Leu Ser His Leu 330 Leu Ser Ala Leu Asn Gly 75 Asn Ser Pro Leo Leo Gin Glu Ser Phe Ala 235 Asp Thr Val1 Leu Leu 315 Val1 Lys Gly Val Ala Lys Gly Thr Tyr Scr Ala 140 Leo Gly Ile Ala 5cr 220 Arg Leu Ile Ser Gly 300 Ala Phe Leu Phe Pro Ala Asp Leu Asp Phe 125 Arg Thr Tyr Trp Phe 205 Trp Asn Lys Thr Leu 285 Glu Val Ile Phe Ser Leu Tyr Phe Leu Thr 110 Lys Leu Leu Tyr 5cr 190 As n Met Met Ile Tyr 270 Asp Leu Val Gly Lys Leu Trp Phe Phe Lys Ile His Val Phe Gly 175 Ala Ser Gly Asp Ile 255 'Ile Phe Val Ala Glu 335 Met Tyr Val1 Pro Thr Asp Ile Leu Ser 160 Gly Ile Asn Leo 240 Phe Pro Leu Asn Ph e 320 Gly INFORMATION FOR SEQ ID NO:1504: SEQUENCE CHARACTERISTICS: LENGTH: 519 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION I1.. .519 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:i504 PC' '9122 IPENUS 6 DEC 1996 1064 Arg Gly Tyr Met Leu Glu Ile Lys Asn Leu Asn His Val Leu Leu His Ser Phe Leu Tyr 145 Met Thr Gin Leu Gly 225 Lys Lys Ser Pro Gly 305 Leu Ser Leu Ser Ala 385 Val Gly Pro Ile Asp 465 Phe Phe Ala Val Phe Leu Leu Leu Asn 130 Pro Gly Ala Leu Lys 210 Giu His Asn Val Leu 290 Ile Leu Val Gin Ile 370 Ser Cys Gly Arg Gin 450 Leu Cys Ser Ile Met Glu Arg Asn His 115 Ala Tyr Ile Leu Ser 195 Ala Ile Glu Leu Tyr 275 Ile Ile Lys Gly Met 355 Gin Gin Leu Glu Ile 435 Lys Ser Asp Leu Val Arg Thr Gly Pro 100 His Met Glu Ile Asp 180 Val Val Val Tyr Lys 260 Tyr Ala Gly Leu Leu 340 Val Ser Gin Asn Arg 420 Ile Ser Tyr Arg Gin Gly Leu Thr Asn Leu Lys Lys Leu Asn 165 Ala Glu Lys Glu Ser 245 Ala Leu Ser Glu Ala 325 Leu Phe Ile Glu Pro 405 Gin Leu Val Leu Val 485 Asn Glu Asn Asn 70 Ile His Asn Gin Ser 150 Ala Gin Lys Arg Thr 230 Lys Leu Gin Val Ser 310 Leu Asn Gin Leu Trp 390 Glu Arg Leu Leu Phe 470 Leu Ile Ser Pro 55 Leu Ile Lys Ala Val 135 Gly Pro Ile Asn Leu 215 Asn Leu Asp Lys Asp 295 Gly Asn Ser Asp Ile 375 His Leu Val Asp Glu 455 Ile Val Asn Gly 40 Arg Leu Ala Ile Ser 120 Gin Gly Lys Gin Ile 200 Ala Leu Leu G 1u Arg 280 Phe Ser Ser Lys Pro 360 Glu His Leu Ala Glu 440 Leu Ser Val Ile 25 Ser Phe Lys Tyr Gly 105 G1n Leu Gln Leu Asn 185 Ala Asp Thr Ile Thr 265 Phe Ser Gly Gly Ala 345 Tyr Ala Leu Asn Ile 425 Pro Leu His Ser Asn 505 Ser Gly Lys Giu Ile 90 Lys Val Asp Arg Leu 170 Gin Leu Arg Lys Gin 250 Leu Phe Leu Lys Giu 330 Phe Ala Leu Ala Phe 410 Ala Thr Leu Asp Giu 490 Leu Lys Pro Ser 75 Ala 31n Leu Glu Gln 155 Ile Ile Leu Vfal Glu 235 Ala Leu Arg Lys Ser 315 Glu Lys Ser Arg Giu 395 Tyr Arg Ser Asn Leu 475 Gly Cys Ser Ser His Glu Gin Met Leu Lys 140 Arg Cys Leu Phe Tyr 220 Leu Ser Glu Pro Ala 300 Ser Lys Pro Leu Phe 380 Leu Ala Ala Ala Leu 460 Asp Lys Val Tyr Ser Asn Ala Asp Ser Lys 125 Phe Val Asp Asp Ile 205 Val Phe Asn Val Ser 285 Lys Leu Ile Tyr Asn 365 Ala Cys Tyr Ile Leu 445 Gin Val Ile Leu Ser Ile Gly Phe Pro Giu 110 Glu Leu Cys Giu Leu 190 Ser Leu Asn Leu Lys 270 Leu Glu Ala Leou Arg 350 Pro Tyr Leu Glu Ala 430 Asp Glu Ile Val Asn is Giu Ala Glu Met Leu Ala Gin Asp Ile Pro 175 Leu His Lys Asp Pro 255 Asp Lys Asn Leu Gly 335 Lys Arg Pro Glu Leu 415 Leu Lys Lys Lys Giu 495 Ser Arg Asn Ile Gln Ser Tyr Val Arg Ala 160 Thr Lys Asp Lys Pro 240 Ala Phe Lys Ile Gly 320 Gin Ile Leu Lys Giu 400 Ser Lys Ser Gin Ala 480 Thr Gly Ala Ile Glu Glu Val Phe Asp 500 Pro Lys His Ala Tyr Thr Lys 510 IPEANUS 18 DEC1996 1065 Arg Leu Leu Glu Ser Arg Leu 515 INFORMATION FOR SEQ ID NO:1505: SEQUENCE CHARACTERISTICS: LENGTH: 183 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...183 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1505 Gly Gly Leu Met Asn Thr Ile Ile Arg Tyr Ala Ser Leu Trp Gly Leu 1 5 10 Cys Ile Thr Leu Thr Leu Ala Gin Thr Pro Ser Lys Thr Pro Asp Glu 25 Ile Lys Gin Ile Leu Asn Asn Tyr Ser His Lys Asn Leu Lys Leu Ile 40 Asp Pro Pro Thr Ser Ser Leu Glu Ala Thr Pro Gly Phe Leu Pro Ser 55 60 Pro Lys Glu Thr Ala Thr Thr Ile Asn Gin Giu Ile Ala Lys Tyr His 70 75 Glu Lys Ser Asp Lys Ala Ala Leu Gly Leu Tyr Glu Leu Leu Lys Gly 90 Ala Thr Thr Asn Leu Ser Leu Gin Ala Gin Glu Leu Ser Val Lys Gin 100 105 110 Ala Met Lys Asn His Thr Ile Ala Lys Ala Met Phe Leu Pro Thr Leu 115 120 125 Asn Ala Ser Tyr Asn Phe Lys Asn Glu Ala Arg Asp Thr Pro Glu Tyr 130 135 140 Lys His Tyr Asn Thr Gin Gin Leu Gin Ala Gin Val Thr Leu Asn Val 145 150 155 160 Phe Asn Gly Phe Ser Asn Val Asn Asn Val Lys Glu Lys Ser Ala Thr 165 170 175 Thr Asp Pro Leu Trp Leu Ile 180 INFORMATION FOR SEQ ID NO:1506: SEQUENCE CHARACTERISTICS: LENGTH: 229 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: PC, o/0 912 2 IPEA/UJS 8 dEC 1996 1066 NAME/KEY: misc_feature LOCATION 1...229 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1506 Val Lys Phe Ser Val Leu Thr Leu Phe Pro Gln Leu Ile Leu Pro Tyr 1 5 10 Phe Glu Asp Ser Ile Leu Lys Arg Ala Leu Glu Lys Asn Leu Phe Glu 25 Leu Glu Val Leu Asn Leu Arg Asp Phe Ser Ala Asn Lys Tyr Gln Lys 40 Ala Asp His Thr Leu Ile Gly Gly Gly Ala Gly Gln Ile Leu Asp Pro 55 Glu Met Ile Glu Asn Ala Leu His Ser Val Lys Asn Pro Lys His Thr 70 75 Ile Phe Leu Ser Ala Val Gly Lys Pro Phe Lys Gln Ile Asp Ala Met 90 Arg Leu Ala Gln Lys Lys His Val Val Leu Val Cys Gly Arg Tyr Glu 100 105 110 Gly Phe Asp Glu Arg Ser Ile Glu Leu Gly Ala Asp Glu Val Phe Cys 115 120 125 Ile Gly Asp Phe Ile Leu Thr Gly Gly Glu Leu Gly Ala Leu Cys Leu 130 135 140 Ile Asp Ser Ile Ala Arg His Ile Gln Gly Val Leu Gly Asn Ala Gin 145 150 155 160 Ser Leu Glu Asn Glu Ser Phe Glu Asn Asn Tyr Leu Glu Thr Pro Asn 165 170 175 Phe Ala Asn Ala Val Phe Lys Ser Lys Glu Ile Asn Lys Ile Pro Ala 180 185 190 Pro Leu Glu Tyr Ser Lys Gly Asn His Ala Lys Ile Lys Gin Leu Lys 195 200 205 Leu Asp Leu Ser Lys Leu Arg Thr Lys Phe Tyr Arg Leu Asp Leu Phe 210 215 220 Lys Gln His Lys Ser 225 INFORMATION FOR SEQ ID NO:1507: SEQUENCE CHARACTERISTICS: LENGTH: 366 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...366 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1507 Arg Glu Gln Trp Phe His Phe Arg Ser Thr Pro Pro Thr Val Val Leu 1 5 10 Met Ala Gly Leu Gln Gly Ser Gly Lys Thr Thr Thr Thr Ala Lys Leu 25 Ala His Tyr Leu Lys Thr Lys Asn Lys Lys Val Leu Leu Cys Ala Cys 40 Asp Leu Gln Arg Leu Ala Ala Val Glu Gln Leu Lys Val Leu Gly Glu 55 IPEAIS 18DE 1996 1067 Gin Val Gly Val Giu Val Phe His Giu Giu Asn Lys Ser Val Lys Giu 70 75 Ile Leu Gin T'yr Thr 145 Asp Gly Asp Asp Giu 225 Asn Ser Leu Ala Leu 305 Val1 Met Leu Ala Ile Giu Val1 130 Phe Ser Leu Val Ile 210 Ala Asp Ser Lys Met 290 Asn Ser Ala Met Asn Val1 Leu Aia As n Asp Pro Phe 195 Ile Lys Phe Leu Asp 275 Val1 Gly C lu Lys Ser 355 Asn Asp 100 Lys Asp Glu Ser Leu 180 Met Ser Asp Leu Ile 260 Thr Asn Ser Ile Arg 340 Gin Ala Ser Glu Ala Giu Ljys 165 Arg Pro Leu Leu As n 245 Ser Asp Ser Arg Asn 325 Leu Ala Leu Ala Vali Leu Ile 150 Gly Phe Giu Ala Ser 230 Gin Met Leu Met Arg 310 Arg Thr Lys Lys Gly Lys Ser 135 Gly Gly Ile Arg Giu 215 Lys Ile Ile Glu Thr 295 Lys Ile As n As n Arg Arg Giu 120 Gly Vali Ile Giy Ile 200 Lys Lys Giu Pro Ser 280 Lys Arg Ile Lys Gin 360 Ala Leu 105 Val1 Gin Ser Ala Ser 185 Val1 Thr Leu Lys Gly 265 Ser Lys Ile Lys Lys 345 Thr Giu Ile Asn Gly Val1 155 Gly Giu Arg Se r Lys 235 Lys Gly Glu Arg Leu 315 Phe Ile Pro Ala Asp Pro Val 140 Vai Ile Lys Leu Val1 220 Gly Lys As n Val1 Giu 300 Gly Asp Ser Lys Gin Lys His 125 Lys Leu Thr Ile Met 205 Leu Gin Leu Met Lys 285 Asn Ser Gin Asp Met 365 Phe Glu 110 Giu Ser Ser Tyr Pro 190 Giy Asn Phe Gly Ala 270 Lys Pro Gly Ala *Leu 350 Arg INFORMATION FOR SEQ ID NO:1508: SEQUENCE CHARACTERISTICS: LENGTH: 270 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .270 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:i508 Arg Lys Ala Met Asn Thr His Leu Lys Gin Leu Ile Glu Ile Ser His 1 5 10 is Leu Asp Lys Giu Ile Asp Ser Leu Ciu Pro Leu Ile Arg Giu Lys Arg 25 Lys Asp Leu Asp Lys Ala Leu Asn Asp Lys Giu Ala Lys Asn Lys Ala PCTi -/0912 IPEAAJS l8 D EC 1996 40 Ile Leu Asn'Leu Giu Giu Glu Lys Leu Ala Leu Ly's Leu Gin Val Ser 55 Lys Asn Giu Gin Thr Leu Gin Asp Thr Asn Ala Lys Ile Ala Ser Ile 70 75 Gin Lys Lys Met Ser Glu Ile Lys Ser Giu Arg Glu Leu Arg Ser Leu 90 Asn Ilie Giu Giu Asp Ile Ala Lys Giu Arg Ser Asn Gin Ala Asn Arg 100 105 110 Giu Ile Giu Asn Leu Gin Asn Giu Ile Lys His Lys Ser Giu Lys Gin 115 120 125 Giu Val Leu Lys Lys Giu Met Leu Giu Leu Glu Lys Leu Ala Leu Giu 130 135 140 Leu Giu Asn Leu Val Giu Asn Giu Val Lys Asn Ile Lys Glu Thr Gin 145 150 155 160 Gin Ile Ilie Phe Lys Lys Lys Glu Glu Leu Val Giu Lys Thr Giu Pro 165 170 175 Lys Ilie Tyr Ser Phe Tyr Glu Arg Ile Arg Arg Trp Ala Lys Asn Thr 180 185 190 Ser Ile Vai Thr Ile Lys Lys Gin Ala Cys Gly Gly Cys Phe Ile Arg 195 200 205 Leu Asn Asp Lys Ile Tyr Ala Giu Val Leu Thr Ser Gly Asp Met Ile 210 215 220 Thr Cys Pro Tyr Cys Gly Arg Ile Leu Tyr Ala Glu Ser Thr His Giu 225 230 235 240 Ser Asn Ala Gin Pro Pro Lys Giu Ser Gin Pro Lys Glu Ser Gin Glu 245 250 255 Giu Ser Gin Giu Giu Ser Gin Giu Glu Ser Gin Glu Ser Val 260 265 270 INFORMATION FOR SEQ ID NO:1509: SEQUENCE CHARACTERISTICS: LENGTH: 567 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein Ciii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .567 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1509 Met Asn Giu Ile Asp Lys 5cr Val Asp Ile Gly Phe Leu Arg Ile Leu 1 5 10 Asp Val Ilie Lys Lys Val Lys Thr Pro Lys Gly Gly Ile Glu Val Leu 25 Arg Thr Leu Ile Asp Phe Thr Pro Lys Ile Glu Asn Ala Leu Asn Leu 40 Ala Thr Lys Ser His Lys Gly Gin Tyr Arg Lys Ser Gly Glu Pro Tyr 55 Ile Val His Pro Ilie Cys Vai Ala 5cr Val Val Ala Phe Cys Gly Gly 70 75 Asp Giu Ala Met Val Cys Aia Ala Leu Leu His Asp Val Val Glu Asp 90 Thr Pro Cys Giu Ile Giu Thr Ile Giu Arg Glu Phe Gly Gin Asp Val 100 105 110
IPEANUS
9 6 i :C996 1069 Ala Glu Thr 145 Val Leu Tyr Leu Ile 225 Asn Ser Ile Leu Tyr 305 Arg Ile Arg Trp Met 385 Asp Asp Gly Asp Gin 465 Val Lys Thr Phe Thr 545 Glu Asn Leu 130 Phe Val Pro Ala Glu 210 Lys Ala His Tyr Asp 290 Lys Phe His Thr Lys 370 Arg Pro Ile Ala Lys 450 Glu Ile Asn Lys Glu 530 Asp Asn Leu- Val 115 Gly Val Arg Lys Lys Ile His Asp 180 Pro Ile 195 Asp Lys Glu Tyr Phe Ala Ser Asp 260 Leu Lys 275 Leu Leu Val Leu Lys Asp Thr Thr 340 Phe Asp 355 Tyr Lys Trp Leu Lys Glu Val Val 420 Ile Ala 435 Ala Thr Leu Arg Pro Arg His Leu 500 Ser Met 515 Asp Ala Cys Gly Leu Gly Asp Ser Ile Ser 165 Lys Ala Ser Leu Ser 245 Phe Met Ala Gly Tyr 325 Ile Met Ala Gin Phe 405 Phe Leu Asp Ser Phe 485 Arg Ile Asp Val Gin 565 Ala Leu Ser Gin 135 Leu Ile 150 Asp Arg Gin Val Ser Arg Phe Tyr 215 His Lys 230 Lys Leu Lys Leu Gin Arg Ile Arg 295 Ile Ile 310 lie Ala Phe Asp His Met Gly Gly 375 Asn Phe 390 Tyr Glu Ser Pro Asp Phe Ala Tyr 455 Gly Asp 470 Ile Trp Ile Gin Asn Ile Leu Lys 535 Glu Thr 550 Thr His Thr Lys 120 Asp Pro Ser Ala Leu His Arg Ile 185 Leu Gly 200 Tyr Ile Asn Lys Glu Lys Val Thr 265 Lys Gly 280 Ile Leu His Leu Leu Pro Glu Ser 345 Gly Ala 360 Val Asp Lys Tyr Leu Ala His Gly 425 Ala Tyr 440 Ile Asn Val Val Met Asp Arg Arg 505 Leu Ser 520 Asp Tyr Thr Leu Ile Arg Ile Asn 170 Ser Met Tyr Gin Lys 250 Arg Ala Leu Asn Lys 330 Ser Glu His His Lys 410 Asp Met Ser Lys Gin 490 Asn Thr Lys Thr Thr Met Gin 155 Met Lys Ser Pro Ser 235 Leu Val Val Lys Phe 315 Glu Val Tyr Glu Asp 395 Asn Thr Val Lys Ile 475 Leu Arg Phe Asn Glu 555 Glu Val 140 Asp Leu Glu Ser Glu 220 Leu Phe Lys Asn Asn 300 Lys Asn Tyr Gly Glu 380 Ser Asp Tyr His Lys 460 Ile Lys Leu Phe Phe 540 Ala Ile 125 Val Pro Thr Thr Ile 205 Glu Leu Asp Arg Ile 285 Pro Pro Gly Glu Asn 365 His Asp Leu Thr Ser 445 Ala Lys Thr Lys Gly 525 Glu Met Arg Lys Ser Ala Arg Ala Leu Asp 175 Leu Ala 190 Lys Asn Tyr Lys Leu Lys Ser Gly 255 Pro Tyr 270 Asp Glu Ile Asp Ile Val Tyr Lys 335 Val Gin 350 Ser Ala His Glu Leu Lys Tyr Arg 415 Leu Pro 430 Asp Leu Leu Leu Gly Asp Ser Lys 495 Glu le 510 Arg Ser G1u Lys Lys Ser Glu Leu Leu 160 Ala Val Glu Asn Leu 240 Phe Ser Ile Cys Ser 320 Thr Ile His Gly Asn 400 Glu Val Gly Asn Lys 480 Ala Asp Val Leu Phe 560 INFORMATION FOR SEQ ID NO:1510: SEQUENCE CHARACTERISTICS: LENGTH: 198 amino acids TYPE: amino acid PCT/ 9 6 /091 2 2 1070 IPEAIUS id DEC 1996 TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...198 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1510 Val Thr Ile Lys Ser Phe Ile Asn Gly Leu Arg Arg Asp His Ala Gly 1 5 10 Lys Asp Lys Lys Gin Ala Gly Phe Gly Glu Ile Phe Trp Gly Ser Val 25 Ser Trp Gly Gin Pro Val Trp Ile Asp Ile His Val Leu Asp His Ile 40 Ala Lys Glu Ile Arg Ser Leu Val Giu Asn Asp Ile Glu Val Gly Ile 55 Val Ile Gly Gly Gly Asn Ile Ile Arg Gly Val Ser Ala Ala Gin Gly 70 75 Gly Ile Ile Arg Arg Thr Ser Gly Asp Tyr Met Gly Met Leu Ala Thr 90 Val Ile Asn Ala Val Ala Met Gin Glu Ala Leu Glu His Ile Gly Leu 100 105 110 Asp Thr Arg Val Gin Ser Ala Ile Glu Ile Lys Glu Ile Cys Glu Ser 115 120 125 Tyr Ile Tyr Arg Lys Ala Ile Arg His Leu Glu Lys Gly Arg Val Val 130 135 140 Ile Phe Gly Ala Gly Thr Gly Asn Pro Phe Phe Thr Thr Asp Thr Ala 145 150 155 160 Ala Thr Leu Arg Ala Ile Glu Ile Gly Ser Asp Leu Ile Ile Lys Ala 165 170 175 Thr Lys Val Asp Gly Ile Tyr Asp Lys Asp Pro Asn Lys Phe Lys Asp 180 185 190 Ala Lys Asn Trp Thr Leu 195 INFORMATION FOR SEQ ID NO:1511: SEQUENCE CHARACTERISTICS: LENGTH: 339 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION 1...339 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1511 Met Asn Ala Leu Lys Arg Ala Cys Leu Arg Leu Met Gly Glu Thr Asn 1 5 10 EDITORIAL NOTE NUMBER 63278/96 THIS SPECIFICATION DOES NOT CONTAIN A PAGE 1071 IPENJUS 18DEC 1996 1072
I
Ile Gly Val Glu Met Ile Val Glu Gly .145 His Phe Gly Leu Val Lys Gly Phe 130 Ph.
Pro Asp Leu Gin Lou Val1 Asp 115 Ile Gly Leu Ala Ile Thr Pro Ala Ala Glu Gly 150 INFORMATION FOR SEQ ID NO:1513: SEQUENCE CHARACTERISTICS: LENGTH: 175 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .175 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1513 1Arg Lys Lys Pro Ph. Lys Giu Arg Ile Asp Leu Met Asn Lys Pro Phe Lou
LYS
Pro Ile Gin
LYS
Lou Giu 145 Ile Asn Lou Ile Gly Thr Lys 130 Leu Lou Ph.
3S His Lys Gly Phe Son 115 Gly Ile Lou Lys Lou Asn Lys Phe 100 Lys Val1 Sen
S
Ile Ala Pro Ala Gin Glu Giy Ala 70 Asn Phe Ile Lou Ser Arg Glu Ala Asn Asn 150 Lou Lys Ser Val1 Asn Ala Ala Glu 135 Pro Ile His 40 Ile Ile Tyr Gin Ala 120 Vali As n Ala 25 Gin Val1 Gly Glu Asp 105 Lys Gin Ala 10 Ph.
Ile Sor Asp Sen 90 Cys Thr Asp Ser Ser Lys Ser Lys 75 Ser Lou Gl1u Lys Gin 155 Gly Gly As n Gly Ph.
Asn Glu Val1 140 Gin Cys Glu Arg Lou Lou Lys Thr 125 Cys Sor Asn Ala Thr Asn Ile 110 Giu His Ile Met Gly Gin Giu Asp Lou Gin Val1 Arg Ph.
Ala Lou Ser Lys Lys Val1 Ile 160 Pro Lou Giu Thr Phe Aia Lou Ala Arg Ala Lou Lys Gly Ile PCT/US 96/0912 2 IPENUS 1 DEC 1996 1073 INFORMATION FOR SEQ ID NO:1514: SEQUENCE CHARACTERISTICS: LENGTH: 219 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...219 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1514 Gly Met Ser Ile Lys Glu Asn Leu Glu Gln Val Arg Asn Glu Phe Lys 1 5 10 Ser Asp Glu Lys Leu Leu Glu Gly Ala Phe Arg Leu Glu Lys Phe Phe 25 Lys Arg Tyr Lys Trp Val Leu Leu Phe Ile Val Val Ala Phe Ile Ala 40 Tyr Leu Gly Asp Thr Lys Leu Gin Asp Tyr Lys His Glu Gin Thr Arg 55 Glu Arg Ile Thr Gin Ile Tyr Asn Glu Val Leu Glu Ser Pro Asn Asn 70 75 Ile Ala Leu Gin Lys Arg Leu Lys Glu Val Ala Pro Glu Leu Tyr Asp 90 Leu Tyr Gin Phe Ala Arg Ala Ser Glu Arg Asn Asp Ala Asn Glu Phe 100 105 110 Lys Arg Leu Ser Gin Ser Ser Asn Giu Ile Val Lys Ala Phe Ala Lys 115 120 125 Tyr Ser Tyr Ala Ser Leu Ser Arg Asp Lys Asn Leu Leu Glu Lys Ser 130 135 140 Pro Ile Leu Lys Giu Met Ser Ala Leu Gin Glu Val Asn Leu Leu Tyr 145 150 155 160 Glu Glu Asn Ser Lys Asp Ala Ile Lys Lys Ala His Gin Ser Leu Ser 165 170 175 Thr Ile Pro Leu Ser Ser Ser Leu Tyr Ala Ile Ile Ser Val Leu Lys 180 185 190 His Tyr Gly Met Leu Glu Asp Ile Gin Gin Asn Pro Ser Lys Pro Thr 195 200 205 Asn Leu Lys Lys Glu Thr Ile Gin Gly Thr His 210 215 INFORMATION FOR SEQ ID NO:1515: SEQUENCE CHARACTERISTICS: LENGTH: 198 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: PCT/US 96/09122 1074 IPEAJS 18 DEC 1996 NAME/KEY: misc_feature LOCATION 1...198 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1515 Lys Arg Tyr Lys Arg Leu Glu Gin Glu lie Lys Lys Arg Asp Lys Met 1 5 10 Ile Val Gly Leu Ile Gly Val Val Glu Lys Ile Ser Ala Leu Glu Ala 25 His Ile GIu Val Gin Gly Val Val Tyr Gly Val Gln Val Ser Met Arg 40 Thr Ala Ala Leu Leu Gin Thr Gly Gin Lys Ala Arg Leu Lys Ile Leu 55 Gin Val Ile Lys Glu Asp Ala His Leu Leu Tyr Gly Phe Leu Glu Glu 70 75 Ser Glu Lys Ile Leu Phe Giu Arg Leu Leu Lys Ile Asn Gly Val Gly 90 Gly Arg Ile Ala Leu Ala Ile Leu Ser Ser Phe Ser Pro Asn Glu Phe 100 105 110 Glu Asn Ile Ile Ala Thr Lys Glu Val Lys Arg Leu Gln Gin Val Pro 115 120 125 Gly Ile Gly Lys Lys Leu Ala Asp Lys Ile Met Val Asp Leu Ile Gly 130 135 140 Phe Phe lie Gln Asp Glu Asn Arg Pro Ala Arg Asn Glu Val Phe Leu 145 150 155 160 Ala Leu Glu Ser Leu Gly Phe Lys Ser Ala Glu Ile Asn Pro Val Leu 165 170 175 Lys Thr Leu Lys Pro His Leu Ser Ile Glu Ala Ala lie Lys Glu Ala 180 185 190 Leu Gln Gln Leu Arg Ser 195 INFORMATION FOR SEQ ID NO:1516: SEQUENCE CHARACTERISTICS: LENGTH: 407 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...407 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1516 Ser Arg Thr Leu Cys Ala Lys Ile Val Leu Gln Lys Glu Arg Lys Lys 1 5 10 Met Glu Ile Gln Gin Thr His Arg Lys lie Asn Arg Pro Leu Val Ser 25 Leu Val Leu Ala Gly Ala Leu Ile Ser Ala Ile Pro Gln Glu Ser His 40 Ala Ala Phe Phe Thr Thr Val Ile Ile Pro Ala Ile Val Gly Gly Ile 55 Ala Thr Gly Thr Ala Val Gly Thr Val Ser Gly Leu Leu Ser Trp Gly 70 75 Leu Lys Gln Ala Glu Glu Ala Asn Lys Thr Pro Asp Lys Pro Asp Lys 90 f.
PCT/US 96/09122 IPEA/US 18 DEC 1996 107S Val Glu Trp Trp 145 Leu Gin Ser Lys Ser 225 Ser Gly Val Tyr His 305 Ser Leu Ser Gin Gin 385 Lys Trp Tyr Asp 130 Asn Ser Lys Tyr Asn 210 Gly Glu Ala Trp Ser 290 Leu Asn Asn Thr Asn 370 Lys Ala Arg Asp 115 Trp Lys Gly Ala Lys 195 Ile Ala Gly Thr Met 275 Thr Thr Lys Ile Thr 355 Asn Thr Lys Ile 100 Leu Gly Leu Leu Thr 180 Asp Ser Gly Ile Leu 260 Gly Ile Val Thr Ile 340 Ser Asn Glu Thr Gin Tyr Asn Glu Arg 165 Leu Ser Ile Arg Thr 245 Asn Arg Asn Gly His 325 Ala Gin Ser Thr Arg 405 Ala Lys Ala Val 150 Asn Arg Ala Asp Lys 230 Ser Leu Leu Thr Asp 310 Ile Pro Ser Asn Glu 390 Leu Gly Ser Ala 135 Asp Phe Leu Asp Asn 215 Ala Ser Ala Gin Ser 295 Gin Gly Pro Gly Thr 375 Pro Ser Lys Leu 120 Arg Met Thr Gly Arg 200 Phe Ser Lys Ser Tyr 280 Lys Asn Thr Glu Thr 360 Glu Thr Gly 105 Leu His Lys Gly Gin 185 Thr Val Ser Asn Asn 265 Val 1 Val Ala Leu Gly 345 Lys Val Lys Phe Ser Tyr Asp Gly 170 Phe Thr Glu Thr Ala 250 Ser Gly Gin Ala Asp 330 Gly Asn Ile Ser Phe Ile 125 Lys Gly Asp Asn Asn 205 Asn Thr Ser Leu Leu 285 Val Gly Gin Asp Lys 365 Pro Gly Pro 110 Asp Gly Thr Val Ser 190 Phe Arg Leu Leu Asn 270 Ala Asp Ile Ser Lys 350 Glu Asn Leu Asn Gly Gly Tyr Asn 175 Phe Asn Val Gin Tyr 255 Gly Pro Phe Ile Ala 335 Pro Ile Asn Leu Lys Gly Gin Lys 160 Met Thr Ala Gly Ala 240 Asp Asn Ser Asn Ala 320 Gly Asn Ser Thr Leu 400 INFORMATION FOR SEQ ID NO:1517: SEQUENCE CHARACTERISTICS: LENGTH: 426 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...426 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1517 Val Ile Asn Thr Thr Ser Met Leu Lys Lys Ile Phe Leu Thr Asn Ser 1 5 10 Leu Gly Ile Leu Cys Ser Arg Ile Phe Gly Phe Leu Arg Asp Leu Met
S.
PCT/US 9 6 /0912 2 IPEA/US 16 DEC 1996 1076 Met Ala Phe Gly Trp Ala Ala Gly 145 Ala Glu Leu Leu Lys 225 Leu Ser Ala Leu Ser 305 Arg Ser Glu Phe Phe 385 Ile Met 25 Ala Asn Ile Leu Gly Ala Gly Val Tyr Phe Ser Phe Cys Tyr Ile 130 Ala Ser Lys Gly Gly 210 Asn Lys Ala Ser Pro 290 Ile Leu Ile Arg Ser 370 Ser Ser Pro Lys Gin Ala Leu Gly 115 Asn Leu Leu Thr Gly 195 Leu Thr Ala Gin Gly 275 Leu Ala Gin Gly Gly 355 Leu Leu Leu Leu Leu Ser Ser Leu 100 Phe Phe Leu Leu His 180 Val Trp Asn Phe Ile 260 Ser Ala Ile Lys Gly 340 Gin Tyr Trp Ile Leu 420 Pro Asn Phe Leu 70 Leu Val Val Ala Asp Glu Trp Tyr Gin Tyr 150 Asn Leu 165 Leu Glu Ala Gin Asp Leu Lys Lys 230 Phe Lys 245 Ala Ser Val Ser Leu Phe Ala Leu 310 Ala Trp 325 Ile Met Phe Ser Leu Leu Leu Tyr 390 Ser Leu 405 Gly Val Leu 55 Pro Gly Leu Glu Leu 135 Lys Cys Ala lie Leu 215 Glu Gin Phe Tyr Ala 295 Lys Phe Leu Pro Gly 375 Ala Phe 40 Phe Ser Leu Asn Thr 120 Leu His Met Leu Leu 200 Phe Tyr Phe Leu Leu 280 Ile Asn Phe Ser Lys 360 Leu Lys Arg Phe Ile Pro 105 Leu Leu Ser Ile Tyr 185 Leu Lys Arg Phe Asp 265 Tyr Ala Asn Leu Lys 345 Asp Leu Leu Arg Ile Phe 90 Leu Lys Val Phe Leu 170 Tyr His Gly Leu Pro 250 Thr Tyr Ile Gin Val 330 G1u Thr Pro Glu Ser Ile Arg 75 Cys Trp Leu Phe Phe 155 Ala Leu Phe Leu Asn 235 Ser Thr Ala Ser Gin 315 Gly Ile Leu Phe Gin Asp Phe Ser Gly Leu Cys Ile 140 Ala Leu Ser Tyr Leu 220 Arg Val Ile Asn Thr 300 Asp Val Thr Ile Gly 380 Lys Ile Ala Ser Val Thr Thr 125 Thr Ser Leu Tyr Pro 205 Gly Ala Leu Ala Arg 285 Ala Leu Leu Glu Thr 365 Leu Lys Phe Glu Ile Leu Lys 110 Pro Thr Ala lie Gly 190 Leu Phe Lys Gly Ser 270 Val Leu Ile Leu Leu 350 Ser Thr Ala Phe Gly Lys Phe Leu Ile Phe Tyr Ser 175 Val Val Lys Lys Asn 255 Phe The Phe Leu Leu 335 Leu Gin Lys Ala Val Ser Gly Met Leu Val Leu Ser 160 Lys Leu Lys Thr Asp 240 Ser Leu Gin Pro Gin 320 Cys Phe Val Leu Lys 400 Leu Gly Leu Ala Ala Ser Leu Ser Leu 410 415 Leu Gly Leu Arg 425 INFORMATION FOR SEQ ID NO:1518: SEQUENCE CHARACTERISTICS: LENGTH: 246 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: PCT/US 9 6 0912 2 IP JUS 18 DEC 1996 1077 ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...246 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1518 Phe Arg Leu Pro Ser Pro Leu Thr Ser Ile Leu Met Arg Leu Asp Tyr 1 5 10 Ala Leu Phe Asn Gln His Leu Ala Asn Ser Arg Glu Lys Ala Lys Ala 25 Leu Val Leu Lys Lys Gin Val Leu Val Asn Lys Met Val Val Ser Lys 40 Pro Ser Phe Ile Val Lys Glu Gly Asp Gln Ile Glu Leu Ile Ala Pro 55 Asn Leu Phe Val Ser Arg Ala Gly Glu Lys Leu Gly Ala Phe Leu Glu 70 75 Asp His Phe Ile Asp Phe Lys Glu Lys Val Val Leu Asp Val Gly Ala 90 Ser Lys Gly Gly Phe Ser Gln Val Ala Leu Leu Lys Gly Ala Lys Lys 100 105 110 Val Leu Cys Val Asp Val Gly Lys Met Gin Leu Asp Glu Ser Leu Lys 115 120 125 Asn Asp Gln Arg Ile Glu Cys Tyr Glu Glu Cys Asp Ile Arg Gly Phe 130 135 140 Lys Thr Pro Glu Lys Ile Asp Leu Ala Leu Cys Asp Val Ser Phe Ile 145 150 155 160 Ser Leu Tyr Cys Ile Leu Glu Ala Ile Leu Pro Leu Ser Gly Glu Phe 165 170 175 Leu Thr Leu Phe Lys Pro Gln Phe Glu Val Gly Arg Thr Ile Lys Arg 180 185 190 Asn Lys Lys Gly Val Val Met Asp Lys Glu Ala Ile Leu Asn Ala Leu 195 200 205 Glu Asn Phe Lys Asn His Leu Lys Thr Lys Asp Phe Gln Ile Leu Thr 210 215 220 Ile Gln Glu Ser Leu Val Lys Gly Lys Asn Gly Asn Val Glu Phe Phe 225 230 235 240 Ile His Phe Lys Arg Ala 245 INFORMATION FOR SEQ ID NO:1519: SEQUENCE CHARACTERISTICS: LENGTH: 849 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION 1...849 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1519 Arg His Val Gln Pro Met Lys Ser Lys Lys Leu Tyr Leu Ala Leu Ile 1 5 10 Ile Gly Val Leu Leu Ala Phe Leu Thr Leu Ser Ser Trp Leu Gly Asn 1078 25 Ser Gly Leu Val Gly Arg Phe Gly Val Trp Phe Ala Ala Ile Asn Lys 40 Lys Tyr Phe Gly Tyr Leu Ser Leu Ile Asn Leu Pro Tyr Leu Ala Trp 55 Val Leu Phe Leu Leu Tyr Arg Ala Lys Asn Pro Phe Thr Glu Ile Val 70 75 Leu Glu Lys Thr Leu Gly His Leu Leu Gly Ile Leu Ser Leu Leu Phe 90 Leu Gin Ser Ser Leu Leu Asn Gln Gly Glu Ile Gly Asn Ser Ala Arg 100 105 110 Leu Phe Leu His Pro Phe Ile Gly Asp Phe Gly Leu Tyr Val Leu Ile 115 120 125 Met Leu Met Val Val Ile Ser Tyr Leu Ile Leu Phe Lys Leu Pro Pro 130 135 140 Lys Ser Val Phe Tyr Pro Tyr Met Asn Lys Thr Gln Ser Leu Leu Lys 145 150 155 160 Glu Ile Tyr Lys Gln Cys Leu Gln Ala Phe Ser Pro Asn Phe Ser Leu 165 170 175 Lys Lys Glu Gly Phe Glu Asn Thr Pro Ser Asp Ser Gln Lys Lys Glu 180 185 190 Thr Asn Asn Asp Lys Glu Lys Glu Asn Leu Lys Glu Asn Pro Ile Asp 195 200 205 Glu Asn His Asn Thr Pro Asn Glu Glu Ser Phe Leu Ala Ile Pro Thr 210 215 220 Pro Tyr Asn Thr Thr Leu Asn Asn Ser Glu Pro Gin Glu Gly Leu Val 225 230 235 240 Gin Ile Ser Pro His Pro Pro Thr His Tyr Thr Ile Tyr Pro Lys Arg 245 250 255 Asn Arg Phe Asp Asp Leu Thr Asn Pro Thr Leu Lys Glu Pro Lys Gin 260 265 270 Glu Thr Lys Glu Arg Glu Pro Thr Leu Lys Lys Glu Thr Pro Thr Thr 275 280 285 Leu Lys Pro Ile Met Pro Ile Ser Ala Ser Asn Thr Glu Asn His Asp 290 295 300 Lys Thr Glu Asn His Lys Thr Pro Asn His Pro Ile Lys Glu Asp Asp 305 310 315 320 Leu Gin Glu Ser Pro Gln Glu Asn Pro Gln Lys Glu Asn Ile Glu Glu 325 330 335 Asn Ile Glu Glu Lys Glu Thr Gin Asn Ala Pro Ser Phe Ser Pro Leu 340 345 350 Thr Leu Thr Ser Ala Lys Lys Pro Val Met Val Lys Glu Leu Ser Glu 355 360 365 Asn Lys Glu lie Leu Asp Gly Leu Asp Tyr Gly Glu Val Gln Lys Pro 370 375 380 Lys Asp Tyr Glu Leu Pro Thr Thr Gin Leu Leu Asn Ala Val Cys Leu 385 390 395 400 Lys Glu Thr Ser Leu Asp Glu Asn Glu lie Asp Gin Lys Ile Gln Asp 405 410 415 Leu Leu Ser Lys Leu Arg Thr Phe Lys Ile Asp Gly Asp Ile Ile Arg 420 425 430 Thr Tyr Ser Gly Pro lie Val Thr Thr Phe Glu Phe Arg Pro Ala Pro 435 440 445 Ser Val Lys Val Ser Arg Ile Leu Gly Leu Ser Asp Asp Leu Ala Met 450 455 460 Thr Leu Cys Ala Glu Ser Ile Arg Ile Gin Ala Pro Ile Lys Gly Lys 465 470 475 480 Asp Val Val Gly Ile Glu Ile Pro Asn Ser Gin Ser Gln Ile Ile Tyr 485 490 495 Leu Arg Glu Ile Leu Glu Ser Glu Leu Phe Gln Lys Ser Ser Ser Pro 500 505 510 Leu Thr Leu Ala Leu Gly Lys Asp Ile Val Gly Asn Pro Phe Ile Thr 515 520 525 Asp Leu Lys Lys Leu Pro His Leu Leu Ile Ala Gly Thr Thr Gly Ser 530 535 540 IPENIJS 18 DEC 1996 1079 Gly 545 As n Glu Thr Met Asp 625 Tyr Gly Ala Val1 Arg 705 Ala Thr Ile Asp Asn 785 C iu dly Ph.
Ph.
Lys Ser Val Gly Val Asn Ala Met Ile Leu Ser 550 Pro Ph.
Asp Giu 610 Ser Leu Lys Ser Val1 690 Val1 Gin As n Lys Lys 770 Tyr Lys Tyr Leu Pro Ser Pro 595 Arg Tyr Ile Giu Giy 675 Thr Gly Ser Gly Lys 755 Asp Gin Lys As n Ser 835 Asp Ile 580 Lys Arg Asn Val Ala 660 Leu Gly Thr Leu Leu 740 Ile Phe Gly Ile Gin 820 Pro Gin 565 Tyr Lys Tyr Giu Vali 645 Giu His Leu Lys Leu 725 Val1 Val1 Leu Asp Thr 805 Ala Arg Leu Ala Ala Ser Gin 630 Ile Phe Leu Ile Ile 710 Giy Arg Asp Leu Asp 790 Ser Ala Asn Lye Asp Ile Leu 615 Ala Asp Pro Ile Lye 695 Asp Arg Leu Ph.
Giu 775 Ile Thr Thr Ala Leu Ile Gly 600 Met Gin Glu Ile Val 680 Thr Ser Giy His Ile 760 Giu Leu Ser Ile Lys 840 Val1 Pro 585 Ala Ser Se r Leu Ala 665 Ala As n Lys Asp Ala 745 Lys Ser Giu Phe Thr 825 Gly 555 Ile Leu Gin Tyr Giy 635 Asp Ile Gin Pro Ile 715 Leu Ph.
Gin Met Ala 795 Gin Glu Arg Asp Leu Ser Lys 620 Val1 Leu Ala Arg Ser 700 Leu Ph.
Ala Lys Pro 780 Lys Arg Leu Glu Leu Pro Thr Val1 605 Val1 Giu Met Gin Pro 685 Arg Asp Thr Thr Giu 765 Leu Ala Gin Giu Ile 845 Leu Lys Pro 590 Ala Lys Ala Met Met 670 Ser Val1 Thr Pro G iu 750 Val1 Asp Val Leu Ala 830 Leu Tyr Met 575 Ile Lye Thr Phe Thr 655 Gly Val Ser Asp Pro 735 Asp Giu Thr Ile Lye 815 Gin Gin Lye 560 Val1 Ile Giu Ile Pro 640 Gly Arg Asp Ph.
Gly 720 Gly Giu Tyr Pro Leu 800 Ile Gly Asn INFORMATION FOR SEQ ID NO:i520: SEQUENCE CHARACTERISTICS: LENGTH: 448 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAM4E/KEY: misc-feature LOCATION .448 (xi) SEQUENCE DESCRIPTION: SEQ ID, Ken Tyr Leu Lye Ile Sen Cys Sen Arg Ile Ala Met Aen Pro Gin Ile 10 Gin Pro Ala Thr Lys Lye Pro Leu Lye Sen Leu Leu Ala Ala Ser Sen PM /0K f91 22 I PE4AM lDEC 1996 1080 0 ly Pro Leu Leu Thr Leu Phe Tyr 145 Lys Leu Glu Ile Met 225 Lys Leu Gly Thr Leu 305 Ala Gly Ser Ser Giu 385 Ala His Ile Asn Leu Val Glu Trp Tyr Asp Ph. Tyr Ala Tyr Tyr Ile Gly Ser Ala Leu 130 Gly Gly Leu Gin Leu 210 Asp Glu As n Ser Asn 290 Ala Asp Leu Val1 Phe 370 His Leu Gly Phe Ph.
Ser Se r Met Lou 115 Leu Val1 Phe Ala Ile 195 Ala As n Thr His Leu 275 Ser Leu Lys Ile 355 Tyr Val1 Ph.
Ph.
Met 435 Ala Ala Leu Val1 100 Leu Leu Val1 Tyr Ile 180 Ser Leu Glu His Lys 260 Cys Ser Ser Ile Val1 340 Giu Thr Arg Gly Glu 420 Val1 Lys Ph.
Phe Pro Ala Ala Gly 165 Ph.
Ala Leu Ala Ile 245 Lys Ph.
Se r Tyr Lys 325 Thr Ala Cys Ala G iy 405 Glu Met Glu Leu 70 Ph.
Ser Thr Arg Thr 150 Ser Ser Phe Ser Thr 230 Lys Ala Tyr Phe Ph.
310 Arg Pro Leu Ile Lou 390 Ser Gly Val, Phe 55 Val1 Gly Ile Lys Leu 135 Tyr Phe Leu Ala Leu 215 Pro Glu Leu Thr Ser 295 Ile Thr Ile Ph.
Ala 375 Gly Ala Ph.
Ile Thr Phe Lys Ile Glu 120 Lou Leu Gin Phe Trp 200 Ph.
Gin Thr Met Ph.
280 Pro Ph.
Gin Val1 Tyr 360 Gly Val Ser Val Ile 440 His Thr Met Leu Lou Gly Lou Met 105 Ile Val Gin Gly Ser Glu Tyr Val 170 Ile Val 185 Arg Tyr Leu Arg Lys Lys Gin Arg 250 Ile Val 265 Thr Val Lys Glu Lou Gin Met Leu 330 Ph. Tyr 345 Giu Ile Val Ile Gly Leu Tyr Ile 410 Gly Tyr 425 Ph. Pro As n dly Asp Ala Gly Ph.
Leu 155 Thr Giu Lou Asn Thr 235 Gly Ph.
Tyr Ser Pro 315 Met Gly Leu Lys Ala 395 Ala Val Lys Asp Ph.
Lys Leu Giu Ser 140 Gly Leu As n Ph.
Ile 220 Asn er Gly Lou Ser 300 Lou Val Ile Ala Ala 380 Tyr Lou Met Lys Ala Pro Ph.
Lys Gly Trp 125 Val1 Lys Val1 Val1 Ala 205 Met Val1 Leu Lou Lys 285 Ph.
Cys Phe Lye Leu 365 Giu Ala Glu Lou Thr 445 Ph.
Thr Met dly Ser 110 Ala Gly As n Gly Tyr 190 Leu G iu Asn Lys Thr 270 Ii.e Ile Gly Ala His 350 Ser Lou Ile Ph.
Ser 430 Tyr INFORMATION FOR SEQ ID NO:1521: SEQUENCE CHARACTERISTICS: LENGTH: 646 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES F'~I~S9~091 2a2 IPENIS 18 DEC 1996 1081 (vi) OR-IGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .646 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:iS2i Lys Trp Lys Asn Leu Met Gin Leu Ser Asn Ala Ly Lys Met Trp Lou Asp Glu Gin Gin 145 Cys Leu Asn Val1 Giy 225 Son Ala Lys Giu Lys 305 Pro Ala Val Phe Lys 385 Arg Leu Ser Ala Val1 Leu Val1 Lou Leu Gly 130 Thr Gly Ala Gin Lys 210 His His Ile Glu Sor 290 Val1 Lys Ile Ser Lou 370 His Giu Ph.
Met Asn Val1 Asn Tyr Lys His Ph.
Leu Asp Gly Ile 195 Thr Asp Lys Gly Val 275 Ph* Arg Thr As n Asn 355 Gly Ser His Val1 Ala 20 Ser Lou Arg Ser Arg 100 His Ala Leu Gly His 180 Ser Arg Tyr Pro Leu 260 Lou Ile Gly Lys Tyr 340 Gly Gly Gly Ala Pro Asn Gly Asp Lou Phe Thr Asn Asp Asp 165 Lou Ile Ph.
Gin Thr 245 Glu.
Lys Ile 11.
Glu 325 Pro Met Sen Asp Met 405 Ph.
rhr H{is Leou Arg 70 Leou Arg 31u Ala Lys 150 Lou A.rg Diu Lou Ala 230 Lou Gly Gin Ser Sor 310 Lys Ala Ile Ala Ph.
390 G ly Cys Lou Pro His Lou His Gin Gly Val 135 Glu Gin Leu Gly Ala 215 Ile Lou Sor Ser Pro 295 Lou Ile Ph.
Lou Asp 375 Pro Ala Ala Ang Gly 40 Lou Val1 Lou Lou Ile 120 Giy Ala Clu Asp Ala 200 Gin His Ile Glu Lys 280 Lys Glu His Lys Asn 360 Lou Leu Ile Thr Ph.
25 Val Asn Phe Trp His 105 Glu Ph.
Ile Gly Asn 185 Ile Asn Asn.
Ala Lys 265 Giu Asn Ala Ala Lys 345 Ala Ala Gly Thn Ph.
eu :ys 5er 1ly Ser Ilie Ser Sor Ile 170 Lou Asn Tnp Ala His 250 Thr Asn Lys Lou Lou 330 Glv Ile Prc Gir Asr 41( Ph~ Cys Lou Asn Gly 75 ?h.
Lys Thr Met His 155 Sor Ile Ile Giu Lou 235 Thr His Ala Met Trp 315 Lys Glu Ala Ser iAsn 395 i Ala SVal k.sp 'ala ;ly Pro ksp rhr rhr Ala 140 Lys Tyr( Val1 Ser Val1 220 Glu Ile Gly Gin His 300 Glu Asn Sor Lys Asn 380 Lou Lou Phe bksp rhr His Leu Pro Ala 125 Sor Val1 Glu Ile Ph.
205 Lou Glu Ile Ser Ile 285 Ph.
Lys Ph.
Lou G iu 365 Asri His Ala Sex Glu MetI Ala Asn I Ala I Sor 1 GlyI 110 Pro Gin Tyr Sor Tyr 190 Ser Glu Ala Gly Pro 270 Asn Glu Ser Asp Ala 350 *Cys Thr *Phe LA! x *Asp 430 rng le ~sp ~ro er .eu is eu :ys L'hr f7 k.sp ;lu :ys Lys Lys 255 Lou Pro Glu Lou Ph.
335 Thr Glu His G11 Tyx 411 TY2 Lou Asp Val1 Lys Ala Asp Pro Gly Ala Lou 160 Ser Ser Gin Asp Lys 240 Gly Ser Asn Val Ser 320 Asn *Arg Gly Lou rIle 400 *Gly *Lou 420 425 Met Pro Ser Ile Arg Lou 5cr Ala Lou Met Lys Lou Lys Ala Lou Ph.
pf I] i]I9 i PEA/US DEC C1996 1082 435 440 445 Ile Phe Thr His Asp Ser Ile Gly Val Gly Glu Asp Gly Ala Thr His 450 455 460 Gin Pro Ile Glu Gin Leu Ser His Leu Arg Ala Leu Pro His Phe Tyr 465 470 475 480 Ala Phe Arg Pro Ser Asp Ala Phe Glu Asn Lys Ala Cys Met Gin Val 485 490 495 Ala Leu Ser Leu Asn Ala Pro Ser Ala Leu Ile Leu Ser Arg Gln Asn 500 505 510 Leu Ser Val Leu Asp Glu Val Ser Lys Glu Gln Val Leu Lys Gly Ala 515 520 525 Tyr Val Lys His His Ser Lys Asp Pro Ile Ile Thr Leu Val Ala Ser 530 535 540 Gly Ser Glu Val Ser Leu Ala Leu Glu Ser Ala Lys Ile Leu Glu Arg 545 550 555 560 Glu Asn Ile Pro Thr Gln Val Val Ser Ala Pro Cys Phe Asp Leu Leu 565 570 575 Val Glu Gln Asp Glu Ser Tyr Phe Lys Glu Leu Phe Lys Gly Lys Val 580 585 590 Leu Val Ile Glu Ala Ser Arg Ala Ile Glu Trp Tyr Arg Phe Ala Asp 595 600 605 Lys Ile Ile Gly Met Asp Ser Phe Gly Ser Ser Ala Lys Gly Asp Lys 610 615 620 Leu Phe Glu Lys Phe Gly Phe Ser Val Glu Asn Ile Thr Ala Gln Ala 625 630 635 640 Lys Arg Leu Leu Asn Ala 645 INFORMATION FOR SEQ ID NO:1522: SEQUENCE CHARACTERISTICS: LENGTH: 273 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...273 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1522 Lys Asp T4r Cys Met Gln Asn Gly Tyr Tyr Ala Ala Thr Gly Ala Met 1 5 10 Ala Thr Gln Phe Asn Arg Leu Asp Leu Thr Ser Asn Asn Leu Ala Asn 25 Leu Asn Thr Asn Gly Phe Lys Arg Asp Asp Ala Ile Thr Gly Asp Phe 40 Leu Arg Leu Tyr Gln Glu Tyr Arg Glu Gln Leu Pro Leu Glu Asp Gin 55 Thr Lys Ala Ser Ala Lys Tyr Leu Asn Arg Asn Leu Asn Arg Val Pro 70 75 Ile Leu Ser Glu Ile Tyr Thr Asp Arg Ser Leu Gly Ala Phe Glu Gly 90 Thr Asn Asn Pro Leu Asp Phe Ala Leu Thr Ser Pro Asn Leu Tyr Phe 100 105 110 Ala Ile Gln Thr Asn Glu Gly Val Ala Tyr Thr Lys Asp Gly His Phe 115 120 125 PC~0 9 IPENIJS 18oDE C 996 Ser Leu 145 Asn Asn Giu Gly Met 225 Ile His Ala Val1 130 Ser Ala Giu Pro Giu 210 Leu Glu Gin Asp Arg G lu Ala Lys 195 Gly Glu Ile Asp Lys Ser Ile Gin 180 Asn Val1 Lys Asn Asp 260 Val1 Lys Asn Ala 185 Gly Asp Ala Met Ala 265 Thr Gly Gly 170 Leu Gin Ser Val 250 Ile 1083 u Asn 140 Ly Ile Ly Ile La Leu ;n Leu Ly Ala 220 -g Glu is ?r Lys ;n Lys INFORMATION FOR SEQ ID NO:1523: SEQUENCE CHARACTERISTICS: LENGTH: 592 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature.
LOCATION .592 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:i523 1Gly Met Ile Ala Leu Asn Ph. Asn Leu Lou Asp Lys Giu Thr Asn Thr Pro Asn Gly Arg Asn Leu Met Phe Gin 145 Asp Pro Lou Ser Asn Leu Lou His Asp Asn 130 His Ala Ciu Ph.
Glu Gly Val Lou Ala Lys 115 Ala Phe Lys Val1 Giu Lys Ile His Val Ph.
Val Ile Asp Phe Sen Phe 100 Lys Ser Tyn Tyr Thr Arg Asp Ala 165 Ile Lys Ser Met Glu 70 Sen Cys Arg Glu Ala 150 Lou Ser Pro Lou Arg 55 Pro Thr Asri Lou Arg 135 Lou Ile Pro Lou 40 Lou G lu Glu Tyr 120 Tyr Giu Gly Ser Asp Pro Lou Ile Ile Asn 105 Ala Ser His Ile Lou Ser Ser Leu Giu Lou Tyr Lys Tyr Lou Giu Lou 90 Met Arg His Gly Lys 170 Val1 Lou Gly Val 75 Giu Ile Met Gin Ala 155 Gin Asp Tyr Asn Ile Asn Ala Met 140 Ile His Phe Tyr Giu Ph.
Ang Ser Asp 125 Ile Sen Val1 Val1 Ph.
Asn Ile Leu Lou 110 Lou Glu Val1 Ala As n Gly Lou Lou Lys Val Lou Ile Lou Ph. Asp Lys Lou Ile Asn Giy Asn 160 Asn Lou 175 Ala Lou u -^^J996 1084 Lys Asn Lys Gin 210 Cys Ile 225 Asp Ile Glu Glu Ser Ile Gin Phe 290 Gin Tyr 305 Glu Leu Asp Leu Tyr Gly Ile G1u 370 Lys Leu 385 Lys Leu Thr Lys Lys Pro Ala Lys 450 Tyr Ala 465 Ala Glu Glu Glu Asn Val Asp Ala 530 Ile Val 545 Leu Glu Gly Met 180 Arg Asp 195 Leu Pro Asp Ala Val Leu Thr Pro 260 Val His 275 Ser Phe Gly Tyr Val Val Ser Phe 340 Asp Arg 355 Lys Tyr Phe Leu Glu Val Glu Met 420 Lys Pro 435 Asn Leu Asn Glu Phe Leu Leu Asp 500 Lys Glu 515 Ile Gin Cys Lys Tyr Ile Asp Cys 580 Thr Leu Ser Ser 245 Leu Lys Arg Val His 325 Ser Glu Gly Glu Ile 405 Pro Pro Lys Lys Glu 485 Phe Leu Ser Lys Tyr 565 Val Ala Leu Phe 230 Leu Asp Arg Pro Gly 310 Ser Gin Ile Gly Phe 390 Asn Phe Ile Ile Lys 470 Lys Glu Phe Tyr Thr 550 Ala Ile Lys 215 Pro Glu Phe Leu Phe 295 Ile Arg Ser Lys Asn 375 Phe Ala Lys Asn Ala 455 Thr Val Glu Asp Ile 535 Ser His Ile 200 Glu Ile Arg Gin Ile 280 Gly Gly Phe Gly Pro 360 Gly Glu Thr Glu Leu 440 Lys Gin Glu Leu Asp 520 Phe Asn Lys 185 Val Ile Leu Val Glu 265 Gin Tyr Met Lys Asn 345 Lys Lys Lys Glu Val 425 Ile Lys Val Lys Glu 505 Lys His Glu Tyr Ser Ala Ala Asp 250 Gly Ala Thr Ser Arg 330 Ser Lys Val Asp Gly 410 Cys Tyr Lys Glu Leu 490 Asn Arg Gin Asp Trp 570 Thr Pro Arg 235 Leu Val Ile Asn Ala 315 Cys His Asp Glu Ile 395 Gly Glu Pro Cys Glu 475 His Leu Phe Glu Gly 555 Leu Gly Tyr 220 Ala Thr Ile Gin Leu 300 Ala Val Ala Lys Thr 380 Phe Ala Lys Thr Glu 460 Ala Glu Ser Asn Leu 540 Leu Phe Pro 205 Ala Gly Ala Phe Lys 285 Phe Asn Phe Ser Asp 365 Thr Asn Arg Ile Gin 445 Glu Phe Lys Ala Ser 525 His Arg Ser 190 Ser Thr Ile Lys Ala 270 Gly Asp Met Ile Gly 350 Lys Leu Thr lie Asp 430 Ser Ile Leu Asn Glu 510 Tyr Ile Ala Leu Leu Asn Leu Phe Lys Pro 240 Phe Tyr 255 Leu Thr Val Lys Leu His Ala Tyr 320 Gly Gin 335 Ala Ile Ile Phe Val Trp Pro Tyr 400 Lys Gly 415 Lys Ser Qlu Gin Ile Lys Lys Val 480 Lys Leu 495 Ile Asp Phe Met Ala Glu Lys Gin 560 Ala Gly 575 Ile Glu Ala Ile Lys Met Ala Leu Lys Glu Trp 590 INFORMATION FOR SEQ ID NO:1524: SEQUENCE CHARACTERISTICS: LENGTH: 116 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: C PGT/U 1/091 2 IPEA/US 1 DEC196 1085 ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...116 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1524 Val His Phe Thr Cys Ile Phe Leu Thr Leu Leu Lys Trp Ile Leu Pro 1 5 10 Ala Lys Asn Lys Gln Ala Cys Lys Lys Pro Pro Thr Arg Ser Ile Gin 25 Gly Leu Gin Asn Ile Gln Gin Asn Ile Pro Pro Gin Val Leu Thr Pro 40 Gin Ile Gin Ala Gly Ile Gin Gly Val Met Gin Gly Phe Gly Ala Leu 55 Ser Ser Thr Leu Glu Ala Pro Leu Leu Phe Ser Lys Gin Asn Val Val 70 75 Ile Gly Gly Phe Giu His Tyr Leu Ser Pro Leu Tyr Gly Trp Gly Lys 90 Ile His Asp Gly Ala His Cys Arg Ile Giu Cys Lys Lys Thr Pro Met 100 105 110 Lys Cys Ile Ala 115 INFORMATION FOR SEQ ID NO:1525: SEQUENCE CHARACTERISTICS: LENGTH: 377 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...377 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1525 Arg Met Asn Phe Phe Lys Ile Leu Leu Met Glu Leu Arg Ala Ile Val 1 5 10 Ser His Lys Gly Val Leu Leu Ile Leu Ile Gly Ala Pro Leu Ile Tyr 25 Gly Leu Leu Tyr Pro Leu Pro Tyr Leu Lys Asp Ile Val Thr Gin Gin 40 Lys Ile Ala Leu Val Asp Glu Asp Asn Ser Phe Leu Ser Arg Gin Leu 55 Ala Phe Met Val Gln Ser Ser Asn Glu Leu Glu Ile Ala Phe Phe Ser 70 75 Pro Ser Met Leu GIu Ala Lys Lys Leu Leu Lys Glu GIu Lys Ile Tyr 90 Gly Ile Leu His Ile Pro Ser His Phe Glu Ala Asn Ile Tyr Lys Gin 100 105 110 Val Pro Val Thr Ile Asp Phe Tyr Ala Asn Ala Asn Tyr Phe Leu Ile 115 120 125 Tyr Gly Ala Leu Ala Asn Ala Val Val Gly Ser Ile Asn Ala Leu Asn 130 135 140 Asp Glu Ile Arg Phe Lys Arg Asn Ala Gin Ile Glu Glu Ala Glu Leu 1086 145 150 155 160 Gly Thr Asp Gly Ile Lys Ile Lys Pro Ile Ala Leu Tyr Asn Pro Ser 165 170 175 Glu Gly Tyr Leu Asn Tyr Ala Leu Ser Ser Val Phe Ile Phe :le Leu 180 185 190 His Gln Val Met Leu Ile Ala Ser Ser Met Phe Thr Ser Ser Arg Arg 195 200 205 Leu Glu Leu Ala Leu Leu Asp Lys Lys Gln Ile Ala Leu Arg Leu Cys 210 215 220 Ala Arg Leu Leu Val Phe Met Gly Ala Phe Ser Val Phe Val Leu Trp 225 230 235 240 Tyr Phe Gly Ala Leu Phe Ser Phe Tyr Gly Ile Glu Arg His Gly Ser 245 250 255 Ala Leu Met Val Phe Leu Asn Ser Leu Ile Phe Met Leu Ala Ala Leu 260 265 270 Ser Leu Gly Ser Phe Leu Gly Ala Trp Ile Lys Asn Glu Ala His Thr 275 280 285 Thr Gin Ile Val Leu Ile Ser Ser Leu Pro Leu Ile Phe Met Met Gly 290 295 300 Phe Val Trp Pro Phe Glu Ser Leu Pro Ser Tyr Leu Gln Val Phe Val 305 310 315 320 Gin Ile Val Pro Ala Tyr His Gly Ile Ser Leu Leu Gly Arg Leu Asn 325 330 335 His Met His Ala Glu Phe Ile Asp Val Tyr Ile His Phe Tyr Ala Leu 340 345 350 Ile Ala Ile Phe Ile Val Ser Phe Ile Gly Cys Val Phe Lys Leu Ser 355 360 365 Ser Leu Lys Lys Ala Cys Glu Asn Ala 370 375 INFORMATION FOR SEQ ID NO:1526: SEQUENCE CHARACTERISTICS: LENGTH: 89 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...89 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1526 Thr Leu Lys Gly Ile Val Leu Phe Arg Leu Ile Ser Ala Trp Val Leu 1 5 10 Gin Asp Lys Phe Leu Phe Val Val Cys Phe Ile Leu Pro Phe Cys Leu 25 Gly Val Leu Gly Thr Gin Ile Phe Lys Gin Glu Thr Pro Arg Gln Leu 40 Pro Ile Val Val Val Asp Leu Asp Lys Thr Thr Thr Ser His Gln Val 55 Ala Phe Glu Leu Gly Ala Thr Ser Ala Val Glu Ile Lys Tyr Gln Val 70 75 Thr Ser Leu Ser Glu Ala Lys Arg Phe 96/09122 iPENUS 16 oc 991 6 1087 INFORMATION FOR SEQ ID NO:1527: SEQUENCE CHARACTERISTICS: LENGTH: 77 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...77 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1527 Ser Met Lys Lys Thr Thr Leu Phe Val Leu Gly Leu Leu Phe Asn Ser 1 5 10 Ser Leu Ser Ala Val Asp Gly Ile Ser Gln Thr Glu Pro Ser Ser Leu 25 Asn Leu Ala Glu Asp Ser Leu Pro Leu Asn His Ser Asn Ala Gln Lys 40 Leu Ser Leu Lys Asn Ala Trp Asn Arg Val Leu Ser Asn His Glu Gly 55 Leu His Ala Gln Asn Thr Pro Leu Ser Glu Arg Val Lys 70 INFORMATION FOR SEQ ID NO:1528: SEQUENCE CHARACTERISTICS: LENGTH: 101 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...101 (xi) SEQUENCE DESCRIPTION: SEQ ID N0:1528 Val Arg Arg Gin Thr Met Lys Lys Val Ile Val Ala Leu Gly Val Leu 1 5 10 Ala Phe Ala Asn Val Leu Met Ala Thr Asp Val Lys Ala Leu Val Lys 25 Gly Cys Ala Ala Cys His Gly Val Lys Phe Glu Lys Lys Ala Leu Gly 40 Lys Ser Lys Ile Val Asn Met Met Ser Glu Lys Glu Ile Glu Glu Asp 55 Leu Met Ala Phe Lys Ser Gly Ala Asn Lys Asn Pro Val Met Thr Ala 70 75 Gin Ala Lys Lys Leu Ser Asp Giu Asp Ile Lys Ala Leu Ala Ile Tyr 90 Ile Pro Thr Leu Lys IPEA/US DEC 1996 1088 100 INFORMATION FOR SEQ ID NO:1529: SEQUENCE CHARACTERISTICS: LENGTH: 159 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...159 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1529 Arg Pro Met Leu His Lys Lys Tyr Arg Pro Asn Val Ala Ala Ile Ile 1 5 10 Met Ser Pro Asp Tyr Pro Asn Thr Cys Glu Val Phe Ile Ala Glu Arg 25 Ile Asp Ile Glu Gly Ala Trp Gln Phe Pro Gln Gly Gly Ile Asp Glu 40 Gly Glu Thr Pro Leu Glu Ala Leu Tyr Arg Glu Leu Leu Glu Glu Ile 55 Gly Thr Asn Glu Ile Glu Ile Leu Ala Gln Tyr Pro Arg Trp Ile Ala 70 75 Tyr Asp Phe Pro Ser Asn Met Glu His Lys Phe Tyr Ser Phe Asp Gly 90 Gin Lys Gln Arg Tyr Phe Leu Val Arg Leu Lys His Val Asn Asn Ile 100 105 110 Asp Leu Asn Lys His Thr Pro Glu Phe Arg Ser Tyr Gln Phe Ile Gin 115 120 125 Leu Lys Asp Leu Leu Lys Lys Ile Val Pro Phe Lys Arg Gln Val Tyr 130 135 140 Arg Gln Val Ile Ala Tyr Phe Arg Lys Glu Gly Tyr Leu Gly Cys 145 150 155 INFORMATION FOR SEQ ID NO:1530: SEQUENCE CHARACTERISTICS: LENGTH: 131 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...131 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1530 PCTUS 96IO912.
IPENS 1b DEC1996 Cys Ser Met Cys Gly Thr Ser Gly cuy Met Ser Phe Phe Asp Thr Gin Leu Val1 130 Asn Lau G1u Ile Asp Ph.
T~yr Ile 115 Asn Lau Arg Ser Ile Phe Ser Leu 100 Gly Ala Met Phe Lou Thr Thr Val1 Phe 10e9 Leu Giy Met Pro Ser Val Ala Ala Gly Val Leu Lys Leu Gly Leu Ala INFORMATION FOR SEQ ID NO:1531: SEQUENCE CHARACTERISTICS: LENGTH: 273 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .273 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:i531 1Tyr Leu Ser Ile Val Val Giu Asp Gin Ala Set Phe Ser Lou Lys so Leu Ser Ala Glu Val Set Met Val Ile His 130 Pro Asp 145 Lys Ser Gly Phe Arg Giu His Asn Lys Set 100 Pro Gin Ile Tyr Giu 180 Lys Asp Gly Leu Ala Ser Phe Ilie Ile Pro 165 Arg Sen Phe Phe His 70 Ph.
Giy Val Lys Thr 150 Ile Ile Gin Set Val Giu Lys Asp 55 Ph. Vai Giu Asn Set Ile Giu Met 120 Glu Lou 135 Asn Asp Giu Giu Cys Pro Ser 25 Gly Asn Val Lau Lys 105 Giu Ph.
Lys His Set 185 Glu Lys Val1 Ala Gly Thr Val 90 Ala Trp Asp G iu Leu 170 Lys Val1 Ile Ile Lys Ala Ile Ile Pro Ile 75 Set Glu Giu His Gly Glu Pto Asn 140 Ile His 155 Asp Met Asp Leu Giu Arg Giu Ile Ph.
Leu Met Gly Lys 125 Gly Thr Cys Set Lau Asp GiU dly Giu Phe Thr 110 Ala Leu Lys Met Lou 190 Lys Val Giy His Asn Leu Giy Tyr Leu As n Giu 175 Thr Glu Gly Ile Ph. Pro Ile Ala Cys Leu Ala Giu Met Arg Lys Asn Leu 160 Cys Pro Arg Arg Gin Arg Ile Val Ile His Arg
ME
ipskjs 18 D EC 1996 1090 195 200 Ser His Gly His Asp Giu Asp 210 215 Giu Ser Giu Tyr Leu Ala His 230 Ser Thr Leu Cys Pro Leu Gly 245 His Tyr Gin Lys Asn Pro Lys 260 Gin Val Ala Thr Ile Asp 250 Gly GiU 265 205 Lou Leu Asp 220 Cys Ala Val 235 Thr Gly Ser Lys Ile Cys Giu Leu Leu Cys His Met 240 Ile Ala Lou 255 Phe Lys Asp 270 INFORMATION FOR SEQ ID NO:1532: SEQUENCE CHARACTERISTICS: LENGTH: 241 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Heiicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .241 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1532 Arg G lu Asn Pro Asn Ile Asp Phe Ser Giu 145 Leu Ile Val Ile Lou 225 Lys Phe Leu Gin Lys Sen Aia Gin Ile Trp Gly Ile Lys Met Ilie Ile Asn Leu Glu Pro Ser Val 130 Lys Phe Phe Ser Phe 210 Giu Ser G ly Asn Thr Lys Asp 115 Pro Lou Asp Giu Thr 195 Leu Asn Leu Ala Lys Leu 100 Ph.
Leu Gin Giu Leu 180 His Lys Lou Thr Lys Lys Leu Pro Gly Lys Thr 55 Gin Gly Giu 70 Lys Sen Val Thr Pro Leu Asp Glu Ser Lys Arg Giu 135 Leu Ile Lou 150 Pro Val Ala 165 Ile Ala Lys Leu Val Val Glu Ala Lys 215 rhr Lys 40 Thn V'al Ala Lys Lys 120 Ph.
Thr Gly Glu Asp 200 Val1 Tyr 25 Gin Leu Lys Phe Ala 105 Ala Lys Lou Ile Ph.
185 Val Val1 Gly Gln Leu Ile Leu 90 Ile Lou Ala Sen Asp 170 Sen Giu Ala Sen Ph.
Lys Leu 75 Ser Ala Asn Leu Arg 155 Pro Gin Lys *Phe *Ala 235 Lou Ile Ile Asn Asp Ph.
Lou Ser 140 Asn Ile Asn Tyr Gly 220 Lys Gly Leu Gin Gly Tyr Lou 125 Lys Ala Ala Ala Lou 205 Asp Alia Lou Ala Lys Asp Lys 110 Lys Gly Ser Arg Ser 190 Asp Val Lou Val Lou Asp Leu Gly Giy Lou Ile Gly Ph. Lou Asp Phe Ang Ph.
Met Arg Lou Tyr 160 Glu Glu 175 *Lou Lou Ser Ala *Gly Giu iArg Lou 240 Lys Lys Gly Tyr Sen Son 230 Lou Giu Ala Tyr Lys Gl1, PCT/US 96 /0912Z.
t-AS 0 iE C1996 1091 INFORMATION FOR SEQ ID NO:1533: SEQUENCE CHARACTERISTICS: LENGTH: 288 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...288 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1533 Lys Ser Trp Phe Phe Tyr Ala Pro Phe Tyr Gly Leu Trp Cys Leu Lys 1 Thr Cys Leu Gin Asp Val Ala Val Ile 145 Ala Ser Thr Pro Phe 225 Phe Leu Tyr Pro Cys Ser Asn Asn Tyr Leu Lys 130 Phe Asp Ala Ser Lys 210 Met Gly Ala Lys Ile Phe Val His Val Ile Leu 115 Thr Pro Ile Ser Gly 195 Ile Ser Thr Pro Arg 275 Ile Lys Ser Lys Ile Leu 100 Glu Asp Phe Ala Gly 180 Ser Tyr Thr Ser Lys 260 Gly 5 Gly Met Asp Ile Thr Ala Gly Tyr Tyr Ser 165 Cys Phe Val Ser His 245 Asn Phe His Ile Ala Phe 70 Ala Asp Asn Val Val 150 Gly Ser Asn Gly Asn 230 Leu Ser Gly Gly Arg Lys 55 Glu Ser Lys Ile Lys 135 Gln Lys Ile Met Asp 215 Lys Asp Trp Leu Met Trp 40 Glu Ile Gly Val Lys 120 Leu Asp Asp Asp Gin 200 Ile Arg Gly Asp Asn 280 Lys 25 Leu Ile Leu Asn Arg 105 Val Ser Ser Gin Asn 185 Lys Pro Thr Phe Met 265 Phe 10 Lys Tyr Ala Ala Ala 90 Tyr Tyr Leu Val Lys 170 Pro Ser Val Thr Ile 250 Thr Glu Lys Leu Met Asp 75 Ile Asp Arg Asn Ser 155 Tyr Ile His Leu Gly 235 Tyr Phe Ala Ala Ala Gln Lys Leu Thr Gly Glu 140 Gly Lys Trp Leu Tyr 220 Phe Leu Thr Arg Lys Val Arg Val Leu Lys Glu 125 Lys Ile Ile His Ser 205 Leu Leu Gln Pro Tyr 285 Val Phe Phe Ser Asn Thr 110 Gly Tyr Trp Lys Val 190 Met Pro Tyr Pro Gin 270 Ile Phe Phe Asp Rla Tyr Lys Leu Glu Val Asn 175 Asn Trp Tyr Pro Phe 255 Ile Asn Trp Leu Lys Lys Asp Glu Leu Ile Ser 160 Met Ala Asn Ile Glu 240 Tyr Arg Pro INFORMATION FOR SEQ ID NO:1534: SEQUENCE CHARACTERISTICS: LENGTH: 149 amino acids TYPE: amino acid PCTL 3/091 e.
IPENUS 6 DEC 1996 1092 TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...149 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1534 Ile Val Arg Lys Lys Leu Met Leu Glu Met Ser Leu Gin Ala Leu Asn 1 5 10 Thr Gln Asp Ser Ser Val Met Ala Gln Ser Leu Leu Val His Ala Phe 25 Phe Ala Ala Leu Leu Ala Leu Ala Phe Met Ile Asn Leu Tyr Thr Leu 40 Phe Lys Glu Lys Asn Phe Ile Gin Leu Asn Arg Lys Ile Tyr Leu Val 55 Met Pro Ala Ile Tyr Ile Leu Leu Ser Ile Ala Leu Leu Ser Gly Val 70 75 Phe Ile Trp Ala Met Gln Gin Phe Glu Phe Ser Phe Ser Ala Val Val 90 Met Leu Leu Gly Leu Leu Leu Met Leu Ile Ala Glu Ile Lys Arg His 100 105 110 Lys Ser Val Lys Phe Ala Ile Thr Lys Lys Glu Arg Met Lys Ala Tyr 115 120 125 Ile Lys Lys Ala Lys Ile Leu Tyr Phe Leu Glu Thr Ile Leu lie Ile 130 135 140 Val Leu Met Gly Ile 145 INFORMATION FOR SEQ ID NO:1535: SEQUENCE CHARACTERISTICS: LENGTH: 119 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...119 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1535 Pro Glu Gly Gly Asn Glu Leu Asn Val Phe Glu Pro Val Ile Ala Tyr 1 5 10 Lys Leu Phe His Ser Phe Val Ile Leu Gly Cys Ala Ile Glu Thr Leu 25 Thr Thr Lys Cys Val Glu Gly Ile Thr Ala Asn Glu Lys Ile Cys His 40 Asp Tyr Val Phe Asn Ser Ile Gly Ile Val Thr Ala Leu Asn Pro His 55 AWNDED SHEET Ile Asp Glu Ala Gly Arg Gin Phe PCT/US 96/0912Z2 IPEAN S 16 DEC 1996 1093 Tyr.Glu Lys Ser Ala Met Ile Ala Lys Glu Ala Leu Lys Ser 70 75 Ser Ile Tyr Asp Ile Ala Leu Glu Lys Lys Ile Leu Thr Lys 90 Leu Asp Asp Ile Phe Lys Pro Glu Asn Met Leu Ser Pro His 100 105 110 Lys Lys His Lys Asp 115 INFORMATION FOR SEQ ID NO:1536: SEQUENCE CHARACTERISTICS: LENGTH: 235 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc feature LOCATION 1...235 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1536 Lys Arg Leu Met Val Leu Phe Leu Ser Ile Phe Lys Lys Ser Phe Asn 1 Asp Leu Ile Ala Ala Val Tyr Ser Leu 145 Gly Lys Ser Ser Ala 225 Phe Ser Val His Leu Ile Leu Ile 130 Leu Val Asn Tyr Phe 210 Thr Leu Leu Asn Ser Val Asn His 115 Leu Phe Phe Thr Gin 195 Phe Leu Ser Ala Tyr Gin Tyr Ile 100 Gin Phe Leu Gly Met 180 Asn Cys Leu 5 Ala Phe Cys Gly Phe Phe Lys Ser Ala Val 165 Ser Leu Tyr Gin Arg Phe Gin Phe 70 Leu Ala Tyr Ile Val 150 Phe Leu Leu Leu Thr 230 Met Gly Thr 55 Phe Ile Ser Tyr Lys 135 Leu Phe Asp Lys Phe 215 Leu Leu Ala 40 Leu Ala Phe Ile Pro 120 Tyr Thr Ser Ile Gin 200 Ser Met Leu 25 Ile Leu Gly Trp Phe 105 His Phe Pro Ile Ala 185 His Leu Leu 10 Ile Phe Pro Val Ile 90 Tyr Val Leu Leu Val 170 Ser Arg Ile Thr Asn Tyr Gin Phe 75 Val 1 Thr Val Lys Tyr 155 Pro Met Leu Pro His 235 Leu Tyr Ser Ala Ile Pro Leu Ser 140 Phe His Ile Lys Phe 220 Gly Asn Leu Trp Leu Leu Glu 125 Leu Ile Phe Phe His 205 Phe Pro Gly Asn Val Leu Val 110 Glu Thr Pro Leu Asn 190 Tyr Asn Ile Gly Asp Phe Ser Val Phe Phe Phe Phe 175 His Arg Phe Leu Ser Tyr Lys Leu Ser Gly Met Ile 160 Phe Gin Phe Phe INFORMATION FOR SEQ ID NO:1537: SEQUENCE CHARACTERISTICS: P CT/b 9 6/0912? iPEMJS 18 DEC 1996 1094 LENGTH: 277 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .277 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1537 Glu Cys Lys Gly Met Glu Ph. Met 1 Leu Tyr Ile Gly His Gly Trp Leu Ser 145 Asn Trp Lys Gly 225 Arg Thr Ser Ile Lou Ser Tyr Phe Gly 130 Trp Ala Lys Gly Ser 210 Val1 Val Asn Asn Ala Gly As n Thr Lys Lys Gly 115 Lys Gly Sen Sen Pro 195 Thr Arg Pro Leu 275 Val1 Thr Thr Ala Tyr Lys 100 Ph.
Gin Val1 Phe Ser 180 Asp Asn Ala Leu 260 Thr 5 Lou As n Gly As n Ala Ph.
Arg Val1 Gly Gly 165 Ala Val.
Thr Asn Leu 245 Tyr Phe Ser Asp Lys 70 As n Phe Val1 Tyr Sen 150 Ile Ala Cys Ser Ile 230 Ile His Ser Ser Gin Lou 40 Cys Thr His Asn Gly Ala Gin Phe Tyr Gly 120 Ala Pro 135 Asp Lou Phe Gly Asn Tyjr Thr Pro 200 Thr Val 215 Tyr Lys Asn Lys Leu Lys Lys Leu 25 Gly G ly Pro Leu Lys 105 Lou Asn Leu Gly Trp 185 Thr Ala His Phe Arg 265 10 Lou Gin Ser Gly As n 90 Se r Phe Lys Ala Val1 170 Lys Tyr Ph.
Asn Lou 250 Asp Lys Ph.
Ala Ala Val1 Gly 75 Gly Leu Asp Ile Asp 155 Ala Giu Cys Gin Gly 235 Ser Tyr Val1 Glu Arg Val Thr Ph.
Asp Tyr Gin 140 Ile le Gin Asn Val1 220 Val Ala Ser Ala Giy Leu Gly Asn Gly Met Gly 125 Leu Ile Gly Ile Pro 205 Trp Glu Gly Leu Leu Asp As n Cys Ile Lou Thr 110 His Asp Asp C iy Ile 190 Asn Lau Ph.
Pro Tyr 270 Gly Leu Gly Val Ser Asn Pro Pro Asn Trp Asn Val.
Ser Lys Aia Asp Met Val Lys Asp 160 Asn Thr 175 Giu Ala Ala Pro Asn Ph.
Gly Val.
240 Asn Ala 255 Lou Gly INFORMATION FOR SEQ ID NO:1538: SEQUENCE CHARACTERISTICS: LENGTH: 676 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES pr9'J 96/0912 2 IPENUS 18DEC 1996 1095 (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...676 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1538 Ala Phe Glu Glu Leu Glu Pro Leu Ser Phe Ser Phe Asn Ser Pro Lys 1 5 10 Gly Ala Cys Glu Ser Cys Leu Gly Leu Gly Thr Lys Phe Ser Leu Asp 25 Ile Ser Lys Ile Leu Asp Pro Asn Thr Pro Leu Asn Gin Gly Ala Ile 40 Lys Val Ile Phe Gly Tyr Asn Arg Ser Tyr Tyr Ala Gin Met Phe Glu 55 Gly Phe Cys Thr Tyr Asn Gly lie Asp Ser Ala Leu Cys Phe Asn Glu 70 75 Leu Asn Lys Glu Gln Gln Asp Ala Leu Leu Tyr Gly Asn Gly Thr Glu 90 Ile Ser Phe His Phe Lys Asn Ser Pro Leu Lys Arg Pro Trp Lys Gly 100 105 110 Ile Ile Gin Ile Ala Tyr Asp Met Phe Lys Glu Gin Lys Asp Leu Ser 115 120 125 Asp Tyr Met Ser Glu Lys Thr Cys Ser Ser Cys Asn Gly His Arg Leu 130 135 140 Lys Ala Ser Ser Leu Ser Val Gin Val Ala Gly Leu Lys Met Ala Asp 145 150 155 160 Phe Leu Thr Lys Pro Ile Glu Glu Val Tyr His Phe Phe Asn Asp Pro 165 170 175 Thr His Phe Asn Tyr Leu Asn Glu Gin Glu Lys Lys Ile Ala Glu Pro 180 185 190 Ile Leu Lys Glu Ile Leu Glu Arg Val Phe Phe Leu Tyr Asp Val Gly 195 200 205 Leu Gly Tyr Leu Thr Leu Gly Arg Asp Ala Arg Thr Ile Ser Gly Gly 210 215 220 Glu Ser Gin Arg Ile Arg Ile Ala Ser Gin Ile Gly Ser Gly Leu Thr 225 230 235 240 Gly Val Leu Tyr Val Leu Asp Glu Pro Ser lie Gly Leu His Glu Lys 245 250 255 Asp Thr Leu Lys Leu Ile Asn Thr Leu Arg Asn Leu Gin Lys Lys Gly 260 265 270 Asn Thr Leu Ile Val Val Glu His Asp Lys Glu Thr Ile Lys His Ala 275 280 285 Asp Phe Val Val Asp Ile Gly Pro Lys Ala Gly Arg His Gly Gly Glu 290 295 300 Val Val Phe Ser Gly Ser Val Lys Asp Leu Leu Gin Asn Asn His Ser 305 310 315 320 Thr Ala Leu Tyr Leu Asn Gly Thr Lys Lys Ile Glu Arg Pro Lys Phe 325 330 335 Glu Pro Pro Lys Glu Lys His Phe Leu Glu Ile Lys Asn Val Asn Ile 340 345 350 Asn Asn Ile Lys Asn Leu Ser Val Gln Ile Pro Leu Lys Gin Leu Val 355 360 365 Cys Ile Thr Gly Val Ser Gly Ser Gly Lys Ser Ser Leu Ile Leu Gin 370 375 380 Thr Leu Leu Pro Thr Ala Gin Thr Leu Leu Asn His Ala Lys Lys Asn 385 390 395 400 Gin Ser Leu Asn Gly Val Glu lie Val Gly Leu Glu Tyr Leu Asp Lys 405 410 415 Val Ile Tyr Leu Asp Gln Ala Pro Ile Gly Lys Thr Pro Arg Ser Asn 420 425 430 Pro Ala Thr Tyr Thr Gly Val Met Asp Glu Ile Arg Ile Leu Phe Ala A, PCT[ '3 96/0912 2 IPEJS 16 DEC 1996 1096 Glu Phe 465 Ile Ser Lys Tyr Leu 545 Thr Ser Thr Ser Asp 625 Gly Ala Leu Gin 450 Asn Lys Cys Gly Glu 530 Ile Leu Lys Gly Leu 610 Ile Asp Gin Glu 435 Lys Val Ile Lys Lys 515 Phe Asp Ser Lys Leu 595 Val Ile Lys Asn Leu 675 Glu Lys Glu Gly 500 Ser Phe Val Gly Asp 580 His Ala Lys Gly Cys 660 Lys Ala Gly Met 485 Ala Ile Ala Gly Gly 565 Thr Phe Leu Asn Gly 645 Glu Lys Gly 470 His Lys Ala Lys Leu 550 Glu Gly Glu Gly Ala 630 Lys Lys Gly Tyr Ser Glu Lys Cys 475 Pro Asp Val 490 Pro Gln Thr 505 Leu Asn Met Lys Ile Ala Ile Thr Leu 555 Arg Ile Lys 570 Leu Tyr Ile 585 Asn His Leu Met Leu Val Ile Ile Asp 635 Ala Ser Gly 650 Ser Tyr Thr 665 Thr 460 Gin Leu Leu Ser Val 540 Gly Leu Leu Leu Ile 620 Met Thr Gly 445 Ser Gly Val Glu Val 525 Lys Gin Ala Asp Gin 605 Glu Gly Pro Lys Arg Asp Gin Ile 510 Glu Leu Asn Lys Glu 590 Val His Pro Leu Phe 670 Phe Gly Cys 495 Lys Glu Lys Ala Glu 575 Pro Leu Asn Asp Glu 655 Leu INFORMATION FOR SEQ ID NO:1539: SEQUENCE CHARACTERISTICS: LENGTH: 276 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION 1...276 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1539 Ala Arg Phe Val Lys Ile Thr Ala Asp Tyr Phe Ser 1 5 10 Val Phe Tyr Arg Ser Ile Thr Met Thr Leu Leu Leu 25 Pro Phe Lys Pro Tyr Arg Leu Lys Ser Tyr Lys Gin 40 Lys Leu Ala Phe Arg Val Val Val Gly Gly Leu Ala 55 Phe Tyr Asn Ile Glu Lys Ile Ser Leu Ala Thr Ala 70 75 Gin Cys Ala Pro Ile Tyr Thr Val Leu Leu Ser Pro 90 Pro Met Glu Leu Leu Ile Gly Gly Phe Met Leu Ala Asn Ala Phe Leu Leu Leu Asn Tyr Lys Phe Ser Lys PCT/US 96/09122 HPAM 1JS 0EC 1996 1097 Ala Cys Glu Lys Lott Lys Arg Ser Ala Leu Ile Ser 100 105 dly Glu Ile 145 Leu Ile Asp Pro 225 Leu Ile Leu Ile Gly Asp Phe 165 Phe Ile Tyr Thr Ph.
245 Gly Sor Ile Leu 150 Gly Lou Ser Ala Arg 230 Lou Leu Asp Leu 135 Arg Met Ser Lou 215 Ile Asp Leu Ser Giy Tyr Lou Giy 185 Giy An Trp Lys Ala 265 Glu Ph.
Asp i55 Gly His Ser Pro Lou 235 Ser Pro Ile Val1 125 Ser Gin Ala Pro Thr 205 Gly Phe Gly Lou Gly 110 Gly Lou Ala Gly Arg 190 Lou Ile Gly Val1 Lou 270 Lou Lou Ala Val Met 175 Lys Gly Ile Lou Ala 255 Lys Val1 Val1 Tyr Ile 160 Phe Giu Gin Ala Tyr 240 Lou Glu INFORMATION FOR SEQ ID NO:i540: SEQUENCE CHARACTERISTICS: LENGTH: 269 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobactor pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .269 (xi) SEQUENCE DESCRIPTION: SEQ ID N0:1540 1Val Met Gin Leu Sen Pro Lou Gin Sen Ala Leu Leu Tyr Pho Ph Phe Sle Ser Gly Ile Pro Val1 Lou Ile Phe Glu so Asp Gin Asn Lys An 130 Gly Tyr Ile 35 Giu Ala Asn Met Asp 115 Lou Lou Pro 20 Val1 Ile Trp Asp Phe 100 Ala Ph.
Lou 5 Giu Met Ser Phe Lou Lou Lou Ala Ile Lys Val Ile Val1 70 Ala Phe Tyr Ile Son Lys Ph.
Sen 55 Lys Lou Tyr Val1 Lou 135 Tyr Thr Leu 40 Tyr Ile Arg Lou Val1 120 Lou Leu Arg 25 Val Asn Ala Lou Ile 105 Lou Ala Tyr Ser Leu Giu Gin Pro 90 Gly Thn Lys Ile Ph.
Ala Ala Lys 75 Ph.
Arg Tyr Sen Lys Asp Leu Lys Ser Lou Lys Ala Val1 140 Thr Leu Gly Asp Val Ile Ile Lou 125 Lou Gin Ser Lou Ph.
Ala Ala Lou 110 Lou Val1 Lys Arg Tyr Asp Lou Lou Met Ph. Tyr Ile Lou His Val Lys Lys Pro Gly Lou Son Ile Pro PCT/Ub 9 6 /O0 9 12a 2- IPEMJS D1996 1099 145 Tyr Leu Ser Ser CYs 225 Pro Ala Leu Leu Ala GJly 210 Leu Tyr Phe Thr Leu Ile 195 Asp Giu Thr Met Leu C ly 180 Phe Phe Leu Leu Ala 260 Ala Phe Leu Lys Lou 230 Lys Ala Cys Ala Val1 Gly 215 Leu Ala Ala Ala Tyr Val1 200 Leu Tyr Leu Gly Phe Ala 185 Leu Pro Ser Leu Ph.
265 INFORMATION FOR SEQ ID NO:1541: SEQUENCE CHARACTERISTICS: LENGTH: 241 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .241 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:i541 Sen Pro Phe Met Asp Arg Lys Leu Leu Arg Leu 1 Ala Pro Gly His Ala Phe Tyr Gin Leu 145 Cys Leu Gly Tyr Phe Val1 Leu Lou Asn Ala Ser 130 Lys Leu Arg Ala Ser Ile Lou Val Lys Pro Leu 115 Glu Pro Val1 Phe Ala 195 Tyr Lys Gly Glu Ph.
Pro 100 Gly Leu Lys Ile Val1 180 Arg
S
Asn Asn Lou Lys Pro Ile Sor Asp Gly Glu 165 Gin Asn Ser Ser Lou Asp Asn Lou Ile Ph.
Tyr 150 Sen Ser As n Asp O ly Cys 55 Sor Ala Tyr Lys Ala 135 Ph.
Lou Ph.
Ser Lys 215 Ser Ala 40 Ala Lys Gin Asp Ser 120 Ser Ile Lys Lys Lys 200 Lou 25 Ile Arg Met Val1 Ala 105 Gin Leu Phe Ser Asp 185 Ser Ph.
Lou Asp Ala Ph.
90 Ile Ile Val Cys Val 170 Lys Ala Leu Asp As n Phe 75 Giu Val Lys Ala Tyr 155 Lys Asn Lou Tyr Tyr Ilie Pro Cys Ser Cys Gly Lys 140 0 iu Leu Ala Lys Asn 220 Gin Asp Gly Lou Ser Asp Asn His 125 Val1 Ala Thr His Val1 205 Pro Lou Asn is Phe Sor Arg Ser Gly Cys Ala Son Val Gin Lys Asn Phe Leu Asp Pro Pro Ph.
110 Ala Arg His Lys Lye Cys Lou Sen Lou 160 Lou Glu Thr 175 Lou Mot Lou 190 Lou Pro Pro Leu Ilie 210 Thr His Asn Sen Asn Gin Sen Asp Thr Lys Giu Val I -021'aEE PCT9 US 6 /09122 IPEM S I DEC 1996 1099 Leu Asn lie Tyr Gln Ile Cys Asn Thr Tyr Ser Ile Lys Ala Pro Leu 225 230 235 240 Asp INFORMATION FOR SEQ ID NO:1542: SEQUENCE CHARACTERISTICS: LENGTH: 429 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...429 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1542 Ser Arg Ser Phe Arg Gly Leu Leu Tyr Tyr Asn Lys Ile Asn Leu Ile 1 5 10 Asn Lys Asp Thr Gly Leu Gin Glu Ile Lys Leu Asp Ile Tyr Ala Thr 25 30 Leu Val Cys Met Val Leu Val Leu Leu Leu Gly Arg Tyr Val Ile Ser 40 Lys Val Lys Phe Leu Arg Asp Tyr Asp Ile Pro Glu Pro Val Val Gly 55 Gly Val Leu Val Ala Phe Phe Ile Met Leu Ala Arg Gin Phe Tyr His 70 75 Phe Gly Leu Gin Phe Asp Ser Ser Leu Lys Asp Pro Leu Met Leu Thr 90 Phe Phe Ile Thr Ile Gly Leu Ser Ala Asp Phe Lys Ser Leu Gin Lys 100 105 110 Gly Gly Lys Met Leu Ala Val Phe Leu Leu Ala Val Ala Gly Phe Val 115 120 125 Val Cys Gin Asn Ala Val Gly Ile Ser Ile Ala Ser Leu Leu Gly Val 130 135 140 Asn Pro Leu Met Gly Leu Leu Gly Gly Ser Ile Ala Leu Val Gly Gly 145 150 155 160 His Gly Thr Ser Ala Ala Trp Ala Asn Phe Phe Thr Gin Pro Pro Tyr 165 170 175 His Phe Ser Ser Ser Leu Glu Val Gly Met Ala Cys Ala Thr Phe Gly 180 185 190 Leu Val Ser Gly Gly Ile Ile Gly Gly Pro Val Ala Lys Tyr Leu Ile 195 200 205 Ser Lys Tyr Lys Leu Glu Pro Lys Asp Thr Lys Glu Lys Asp Thr Leu 210 215 220 Glu Gly Val Val Ser Lys Gly Phe Glu Thr Pro Lys Glu Gin Arg Leu 225 230 235 240 Ile Thr Ala Ser Ser Phe Val Glu Thr Leu Ala Leu Ile Ala Ile Ala 245 250 255 Leu Leu Val Gly Thr Phe Leu Ser His Leu Met Pro Lys Ser Phe Thr 260 265 270 Leu Pro Thr Phe Val Trp Cys Leu Phe Val Gly Val Ile Leu Arg Asn 275 280 285 Ala Leu Ser Phe Phe Lys Ile His Ser Val Phe Asp Arg Glu Val Ser 290 295 300 Val Ile Gly Asn Val Ser Leu Ser Leu Phe Leu Ala Tyr Ala Leu Met
PCT/US
IPENUS
1100 305 Ser Ile Thr Gly Met 385 Val Ala Leu Val 340 Val Gly Ile Leu Gly 420 Lys Met 345 Tyr Ala Gly Phe Pro 425 Leu 330 Ile Asp Thr Pro Val 410 Phe 315 Ala Leu Ala Pro Ser 395 Asp Phe Val Tyr Ala Thr 380 His Ile Pro Pro Val Val 365 Ala Val Ile Ser Leu Val 350 Leu Met Ala Asn 18 DEC 1996 320 Val Val Ala Asn Ile 400 Leu INFORMATION FOR SEQ ID NO:1543: SEQUENCE CHARACTERISTICS: LENGTH: 191 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE; ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...191 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1543 Lys 1 Glu Ser Val Ser Gly Met Lys Asp Asp 145 Ile Arg Phe Lys Glu Leu Gly Arg Cys Ala Cys 130 Phe Pro Arg Val Gly Asp Gin Asp Phe Gin Trp 115 Val Glu Ser Ile Leu Asn Ile Asn Asn Lys Leu 100 Glu Val Ser Gly Arg 180 Arg 5 Ala Leu Ala Gly Thr Gin Glu Gly Leu Ile 165 Leu Ser Ile Ser Arg Ile Lys Met Leu Ser Val Tyr 10 Leu Met Ser Gly 70 Leou Lys Lys Ser Ser 150 Asp Asp Glu Leu 55 Asp Val Glu Asn Ala 135 Gln Ser Lys Asn 40 Gly Gly Phe Arg Glu 120 Phe Lys Lys Arg 25 Ala Ala Tyr Glu Ala 105 Asp Lys Ala Gly Ala 185 10 Val Ala Lys Thr Met 90 Lys Leu Gly Arg Arg 170 Leu Met Val Leu 75 Lys Lys Glu Gly Phe 155 Val Glu Ala Ile Ala Leu Val Cys Leu 140 Lys Asp Glu Leu Ile Arg Ala Gly Asp 125 Glu Ile Lys Trp I Glu I Leu Arg Lys Val 110 Val Pro Ala Arg Ala 190 jeu Arg Cys Leu Ser Val Leu Phe Cys Arg 175 Tyr Leu Ala Gly Val Pro Ile Val Leu Asp 160 Leu Ser Ala Trp Leu Ser Ser His INFORMATION FOR SEQ ID NO:1544: PCT/LS 96/0912.2 IPENUS l18DEC 1996.
1101.
SEQUENCE CHARACTERISTICS: LENGTH: 441 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .441 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1544 Asn Ala His Asn Leu Lys Asp Lys Thr Ph. Gln Gly Gly Phe Glu Lou Ser Lou, 1 5 jeu Thr Thr Pro Lys Glu eu Lou Ala Ile Asn Leu k.sp Phe Ser Lys Pro Thr so Pro Lys Thr Lys Asp Gtn 70 Lys Gly Met Ile Ph. Tyr Gin Tyr Arg Tyr Ala Gtn 100 Leu Gtu Ser Lou Lys Ser 115 Thr Arg Lys Gln Asp Phe 130 Ala His Sen Asn Ala Lou 145 150 Gly Asp Sor Lou Asn Lys 165 Ile Asn His Lou Lou Ala 180 Ala Sor Val Tyr Ph. Lou 195 Arg Tyr Ph. Pro Tyr Arg 210 Trp Val Ph., Lou Lou Gly 225 230 Tyjr T'yr Ser 55 Lys Thr Ph.
Cys Lys 135 Val Asp Ile Ph.
Asn 215 Tyr Sen Tr 25 Lou G1i 40 Lou Asi Thr Ty, Thr 11 Ph. Gi' 10 Ph. Ph 120 Son Hi Gly As Lou Ar Sen G1 18 Sor Le 200 Ala Pt~ p Cys Gly Val Val Lou 30 Ls o 5 n 9 Tyr Ala Phe Lys 90 Lys Gtn Lou Lou Asp 170 Ph.
Ph.
Lou Gln Val 7S Glu Ile Thr Ang Tyr 155 Ang His Tyr Asn His Ile Lou Li* Lys Pro Lou Lys Pro Tyn Son 125 His Ph.
140 Arg Ala Ala Asn Lou Gly Thr Pro 205 Ile Gly 220 Lou Lou Lys Cys 110 Ph.
Ile Lou Ala Ile 190 Lou Val Gln Gln Asn Ser Son Asp Ph.
Lou 175 Lou Glun Lot: Pnc Tyr Lou Ph.
Lou Son Ile 160 Gly Sen Lys Val Son 240 eo Tyn Asp Lou Lou Lou Lou ASP Ph. Lot Ph.
Ph.
Ile Lou Gln 305 Ile Ala Gly Val Ph.
Gly Ala Son 290 Ile Ala Ph.
Lou Gly Arg Val I lo 275 Val Ph.
Lou Phe I le 355 Lou Ala Ph.
245 Arg Ile 260 Ala Lou Cys Gly Ph. Lys Ser Val 325 Pro Met 340 Phe Thr Gly Ser Lou Lou Lou Val Asp 310 Lou Ph.
Val Lou Son Pro Trp 295 Sor Vat Ser Ph.
Leu Gly Ph.
Lys 280 Tyr Sen Ph.
Pro Ph.
360 Asp Lou Lys 265 Lou Ile Ph.
Lou Tyr 345 Pro Asr Lou 250 Lou Lou Ph.
Ph.
Asn 330 Gin Lou Ile ;ly Lou Ph.
Lou Lys 315 Met Lou Son Lou Ph.
Val Sor Ph.
300 Ang Lou Phe Lou Ser Lou Lou Val 285 Lou Sor Ilto Ser *Ph.
365 MeNt Ala Ala 270 dly Lys Ph.
Val I le 350 Lou Pnc 255 Cys CyS Ph. Lou His Thn Gin Ala 320 Ala His 335 Pro Leu His Ala Lou Thr Ile 385 Leu Met Ile 370 Pro Phe Asn Ile PCT/US 96/0912 2 1102 IPEVUS 18 DEC1996 375 380 Thr Ile Ser Val Ser Ser Pro Leu Trp Leu Leu Gly Ala His 390 395 400 Leu Thr Ile Leu Ser Val Arg Phe Phe Lys Val Tyr Leu Ser 405 410 415 Val Leu Ser Met Gly Phe Phe Leu Tyr Cys Cys Tyr Gln Tyr 420 425 430 Met Pro Ser Leu Ile Val Gly 435 440 INFORMATION FOR SEQ ID NO:154 5 SEQUENCE
CHARACTERISTICS:
LENGTH: 302 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...302 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1545 Glu Ala Phe Lys Ala Asp Thr Thr Ile Ser Met Gly 1 5 Cys Leu Leu Ser Asp Lys Ala Lys Asp Tyr Ile Gly 25 Gly His Leu Gly Val Phe Asn Gin Ile Tyr Glu Ile 40 Phe Leu Leu Glu Lys Ser Asp Leu Lys Leu Pro Leu 55 Asn Ala His Lys Gly Asp Tyr Gly His Ala His Val 70 His Ser Gly Ala Gly Leu Leu Ser Ala Leu Ser Ala 90
N.
Ser Asn Ser Lys 145 Tyr Pro Ile Phe Thr Gly Lys Ala 130 Lys His His Ser Ser 210 Leu Val Pro 115 Ph& Trp Lys Pro Met 195 Gin Ile Val 100 Leou Ala Leou Glu Lys 180 Leu Lys Ala Ser Ile Gin Ala Glu Leou Glu Val 165 Glu Glu Tyr His Leu Gly Leu 150 Leu Phe Leu Pro Gin Val Met 135 Ala Gin Leu Leu Lys 215 Gly Phe 120 Gly Pro Ala Ser Asp 200 Val Arg Leu 105 Cys Leou Cys Leou Leu 185 Val Val G1u Cys Glu Glu Asn Phe Glu Asn Ile 140 Val Leu Asp 155 Glu Lys G1u 170 Leu Lys Ser Lys Leu Glu; Leu Leu Leu 22( Phe lie As 235 Asp Val Lei 250 Pro Leu As] Ala Ile Lys Ser 15 Glu Leu Lys Val Pro Thr Asp Thr 45 Arg Asp Arg Lys Leu Leu Gly Lys Leu Ser Phe Gly 95 Ile Thr Ser Asn 110 Pro Lys Lys Leu 125 Pro Lys Asp Ph.
Ala Gly Val Phe 160 Val Ile Leu Thr 175 Val Gly Il0 Asn 190 Ile Ala Arg Asp 205 z Lys Gly Ala Asn i Asn Leu Gly Ser 240 u Ala Gly Leu Ile 255 Ala Ala Ile Asn 225 Val Ala Leu Ala Lys 245 Val Ser Leu Leu Ser 260 230 Ala Gly Ser Gly Gin Asn Tyr Thr 265 270 9 6 091 ?2.
IPENS lb DEC 1996 1103 Ala Ser Leu Ala His Ala Leu Ala Gly Leu Glu Phe Lys 275 280 285 Ala Leu Thr Pro Leu Asp Leu Ile Glu Lys Ile Lys Arg 290 295 300 INFORMATION FOR SEQ ID NO:1546: SEQUENCE
CHARACTERISTICS:
LENGTH: 375 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...375 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1546 Asn His Tyr Leu Leu Ala Leu Ala Ser Lys 1 5 Thr Met Leu Ala Val Gly Ala Thr Gly Phe Pro Ike Ala L Thr Asn T 3 Lys Ile I Leu Gly Asn Phe I Trp Leu Glu Ile Phe Arg 130 Asp Arg 145 Gly Ile Lys Asn Asn Glu Asn Leu 210 Glu Phe 225 Pro Leu Leu Ile Asp Tyr hr I 15 Pro Thr Leu ;ly Arg 115 Leou Trp Asn Leou Asn 195 Gin Leu Pro Ile Cys 275 Pro Arg Ser ;lu Phe 100 Arg Gly Phe Ser Gly 180 Leu Ile Sel Prc Gl 261 Cy; Ala S Phe 1 Met Ala Glu Pro Val Leu Ser 165 Phe Glu Ala Leu o Ile 245 y Ser 0 s Val Ser Ala Lys 70 Leu Ser Asn Ser Ser 150 Val Phe Ser Let 25 Phe Glu Pr 40 Phe Glu Ly 55 Ser Ile Gl Gin Lys Al Leu Ser Ly 10 Pro Lys Ar 120 Val Asp G1 135 Gin Ile G1 Leu Thr As o y a s 5 g u 10 u Asp Ser Phe Glu Leu .90 Asp Leu Val Ln !p Ser Asp Val Ser Pro His 215 Thr Pro 230 Gly Asn Gly Pro His Ala Ala Arg 185 Pro Phe 200 Phe Glu Tyr Leu Lys Gin Asn Arg 265 Ser Phe 280 Asn Pro Lys Ala 170 Ile Glu Glu Tyr Gl 25( Il Al Gl' Glu Ile L Leu Asp T 4 Ala Gly V Val Met A 75 Cys Ser L Leu Glu Leu Tyr Phe Glu 1 140 Leu Val 155 Lys Lys Ala Thr Val Glu Val Asp 220 Ser Thr 235 i Lys Gin 0 a Gly Gin a Leu Lys u Thr Val ys A 3 yr I al S la I ieu G la I Ile 125 Leu Lys Leu Lys Leu 205 Thr Tyr Glu Gly Asp 285 Ser ys sn 0 le er le lu Ile la Cys Ala Arg Il 19( Al Cy Al Ly Il 27 Le Th Val Ala Asp Ile1 Val Val Ser Thr Gly Gly Asn Asn Lys Lys Asp Ala Gin 11e Glu Glu 160 Gly Leu 175 e Lys G1u 0 a Arg Ser s Ala Ala a Pro Asn 240 s Lys 11e 255 e Glu Phe 0 u Asn Ile ir Asp Tyr Lys Ser Val 290 Asp Thr Ser Met Leu Asn CVS 295 300 Asp Thr Leu Tyr Phe Glu Pro Ile His Phe Glu Cys.Val PCT/IJS 96/0912.2.
I PEAIUS 18 D EC 1996 1104 310 315 320 Lys Ser Ile Ile Gin Arg Glu Arg Val Asp Gly Ile Ile Val His Phe 325 330 335 Gly Gly Gin Thr Pro Lou Lys Leu Ala Lys Asp Leu Ala Lys Met Gin 340 345 350 Ala Pro Ile Ilie Gly Thr pro Ph. Lys Val Ile Asp Ile Ala Giu Asp 355 360 365 Arg Glu Lys Ph. Pro Ser Ph.
370 375 INFORMATION FOR SEQ ID NO:1547: SEQUENCE
CHARACTERISTICS:
LENGTH: 152 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .152 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1547 Arg Pro Val Ile Ser Ala Lys Giu Giy Ser Asp Pro Ser Ser Leu Ala 1 S 10 is Tyr Asn Thr Ile Giu Ser Ala Ile Ala Lys Aen Ile Asp Giu Val Ph.
25 Ile Asp Thr Ala Gly Arg Leu His Asn Gin Thr Asn Leu Lys Asn Giu 3S 40 Lou Sen Lys Ile Ala His Thr Cy5 Sen Lys Val Leu Lys Asp Ala Pro 55 Phe Tyn Lys Ph. Leu Ile Lou Asp Gly Thr Gin Gly 5cr Ser Gly Lou 70 75 Thr Gin Ala Lys Ile Ph. His Giu Thr Lou Ala Lou Asp Gly Val Ile 90 Met Thr Lys Lou Asp Gly Thr Ser Lys Giy Gly Ala Ile Leu Ser Val 100 105 110 Lou Tyr Glu Lou Lys Lou Pro Ile Lou Tyr Lou Gly Met Gly Giu Lys 115 120 125 Giu, Asp Asp Lou-Ile Ala Phe Asp Glu Giu Arg Ph* Ile Glu Asp Lou 130 135 140 Val Asp Ala Val Ph. Val Glu Gin 145 150 INFORMATION FOR SEQ ID NO:i548: SEQUENCE CHARACTERISTICS: LENGTH: 231 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: PCT/US 96/0912.2 IPEA/US 18DEC1996 1105 ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...231 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1548 Asn Leu Arg Ile lie Thr Ile Lys Thr Ile Phe Arg Asp Phe Cys Lys 1 5 10 Glu Arg Leu Lys Arg Ala Lys Ser Lys Asn Lys Val Arg Asp Lys Leu 25 Ala Cys Lys Leu Leu Phe Trp Lys Leu Lys Asp Tyr Gin Asn Ile Leu 40 Leu Tyr Ser Pro Leu Gly His Glu Leu Asp Ile Arg Pro Leu Ile Leu 55 Lys Leu Arg Gin Lys Asn Lys Arg Val Trp Leu Pro Lys Ser Ile Lys 70 75 Lys Gly Ala His Phe Ser Lys Glu Gly Phe Thr Ile Ala Pro Phe Arg 90 Leu Pro Leu Arg Arg Leu Gly Trp Phe Asp Glu Pro Ser Leu Ser Arg 100 105 110 Tyr Tyr Lys Arg Glu Leu Asp Cys Ile Val Val Pro Ile Leu Gly Met 115 120 125 Asp Thr Ser Phe Arg Arg Val Gly Phe Gly Leu Gly Met Tyr Asp Arg 130 135 140 Ser Leu Pro Gin Leu Phe Lys Lys Gin Leu Lys Arg Pro Leu Val Ile 145 150 155 160 Phe Val Ser Arg Glu Leu Ala Leu Ala Asn Gly Ile Leu Thr Asp Ala 165 170 175 Tyr Asp Ile Glu Ala Asn Leu Tyr Met Asn Ala Arg Ile Val Met Lys 180 185 190 Asn.Asn Lys Arg Lys His Tyr Glu Gin Arg Val Asn Leu His Phe Ile 195 200 205 Arg Ser Leu Gly Ser Val Phe Asp His Arg Ser Asn His Val Leu Cys 210 215 220 Asp Glu Lys Asp Leu Leu Arg 225 230 INFORMATION FOR SEQ ID NO:1549: SEQUENCE
CHARACTERISTICS:
LENGTH: 200 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc.feature LOCATION 1...200 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1549 Arg Ile Ile Lys Gly Asn Ile Met Ser Ser Gly Leu Ile Tyr Ile Ser 1 5 10 Leu Glu Val Leu Val Ala Cys Leu Ile Thr Ala Leu Ile Met Tyr Tyr 25 Val Met Lys Lys Ile Tyr Tyr Ala Arg Gly Gin Ala Ile Leu Lys Gly PT/US 96/091ZZ IPEAUS 18DEC1996 1106 Ala Glu Gin Glu Asp Arg Ile 145 Met Glu Glu Ser Ala Tyr Ala Glu Gin 130 Cys Ala Gin Glu Ala Glu Glu His Lys 115 Ile Lys Tyr Glu Ala 195 Lys Glu Asn Leu 100 Arg Leu Glu Thr Leu 180 Phe Met Lys Gin Glu Lys 120 Arg Lys Ile Lys Leu 200 Glu Ser Leu Ala 105 Glu Glu Ala Lys Ser 185 Phe Gin Gin Gin Lys Asn Leu Ser 170 Ala Val Gin Lys Arg Glu Ala Tyr 160 Leu Glu INFORMATION FOR SEQ ID NO:1550: SEQUENCE CHARACTERISTICS: LENGTH: 350 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION 1...350 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1550 Ile Arg Ser Ser Asn Asp Thr Gin Thr Thr Gin Thr Pro Trp His Ser v 1 Asn Lys His Glu Ile Pro Glu Ile Ala 145 Thr Lys Ser Ile Pro Lys Lys Val 130 Asn Arg Arg Ala Lys Pro Leu Pro Lys Lys Lys Lys Glu 100 Asn Asp 115 Leu Asp Leu Val 5 Pro Glu Asn Lys Glu Ala Thr Ala Cys Leu 165 Lys Lys Glu Glu 70 Ile Glu Trp Gly Glu 150 Pro Thr Arg 55 Ile Pro Asn Ile His 135 Lys Thr Thr 40 Ser Pro Lys Glu Lys 120 Gly Asp Pro 25 Lys Ala Lys Lys Ser 105 Thr Gly Ile 10 Lys His Lys Lys Glu 90 Lys Lys Lys Val Tyr 170 Pro Ala Lys Glu 75 Ile Asn Arg Asp Leu 155 Ile His Glu Ile Pro Gin Lys Cys 140 Glu Lys Ser Ile Pro Lys Ile Lys 125 Gly Val Lys Lys Pro Lys Lys Phe 110 His Ala Val Glu His Lys Lys Glu Ile Lys Met Lys Ala Ala Lys Glu Ile Ala Lys Ser Phe 160 Leu His Lys Glu Lys Lys Arg Gly Ser Val Leu Leu Thr Arg 175
A
.9"Mommemirm POUS 96 091?.2 IPEAJUS 18 DEC1996 1107 Asp Lys Lys Thr 225 Asp Ser Val Val Lou 305 Glu Lys Lys Arg 210 Ala Asp Lou Gin Asp 290 Met Ser Asp Gly 195 Ser Arg Val Asn Tyr 275 Giy Pro Lys 11e 180 Ala Thr Ser Asn Thr 260 Gly Gly Ser Arg Asp 340 Ile Leu Asn Arg 230 Met Arg Lou Arg Lou 310 Gin
ASP
Phe Ala 215 Ala Asp Leu Gin Giu 295 Ile Ser Leu Ile 200 His Arg Tyr Ser 280 Gly Giu Lys Ser Val 185 Ser Gly Lys Phe Val 265 Val Pro Ile Pro Phe 345 Ala Val Ile Val Ser 250 Ser Arg Ph.
Gly 330 Phe Arg His G iu Ala 235 Lys Asn Lys Trp 315 Gin Ser Leu 190 Ser Ph.
Giu Phe Ala 270 Pro Ala His Leu Asp 350 Ala Ile Leu Asn Lou 255 Ile Asp Gly Ala Ala 335 Msn pro Ser Lys 240 Msn Asp Val Ala Ile 320 Lys Gly Ile Ala Gly Ile Asp INFORMATION FOR SEQ ID SEQUENCE CHARACTERISTICS: LENGTH: 186 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL; YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc..featuro LOCATION .186 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1551 Arg 11 Ph.
Ser Lou Ile Arg Lou Asn 145 Val Sor Met Msn Val Lys Lys Lys Gly Lys Pro Gin Ser Asp Lou Pro so Lys Ala Arg Glu 130 Msn Ang Ser 3S, Giy Thr Arg Gin Phe 115 Arg Lys Val Ser Vai Phe Gin Lou 100 His Ala Ile 5 A.sp 110 Gly Tyr Arg as Giu Gly Cys Ala Val Asp Arg Met Thr Lou met Lou 55 Val Ile Tyr Ile GlU Gly 40 I10 Sen Giu Gin Lys 120 Lys 25 Ser Giy Lou Ile Msn 105 Ph.
Lou Gly Lys Glu Msn Gly Lye is Thr Thr Ile Giy Thn Giu 90 Gin Ph.
Gly Gin Phe Val Ile Ph.
7S Lys Giu Ph* Asn Asn Glu Lou Giy
LYS
Cys Giu Ser 125 Aia Lou Giu Gly Glu Arg Val 110 Ph.
Ile Ph.
Gly Val Ala GiU Ph.
Asp Ala Asp Trp Pro met Lys Sen Glu Giu Val 160 Asn Lou Cys Ala Gly Asp Ala 135 Gin Giu Giy Met Gly Gin
ISO
Asp Giu 155 Lys Gin Glu Cys Trp Giu Ph. Ile Thr Ser Ang Lys POT/US 9 6 0912 IPEA/US 1 DEC 1996 1108 165 170 Phe Val Thr Ser Arg Gly Lys Thr Glu Ile 180 185 INFORMATION FOR SEQ ID NO:1552: SEQUENCE
CHARACTERISTICS:
LENGTH: 362 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION 1...362 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1552 175 Lys Arg Asp Gln Met Ala Glu Glu G 1 5 Lys Lys Ile Gln Lys Ala Arg Glu G 2 Glu Val Val Gly Phe Leu Gly Leu L 40 Val Phe Phe Ile Trp Trp Val Asp G 55 Val Leu Lys Asp Phe Ser Leu Asp I 70 Leu Phe Asn Gln Leu Ala Lys Asp 85 Leu Ile Ile Leu Met Val Val Ala I 100 Gly Trp Leu Phe Ala Pro Lys Val 115 120 Asa Pro Ile Asn Gly Val Lys Asn 130 135 Asp Gly Ser Leu Ile Thr Leu Lys 145 150 Phe Phe Ile Ph* Ser Leu Phe Leu 165 Leu Asn Leu Gln Gly Gln Leu Leu 180 Leu Ile Ser Ser Leu Leu Phe Leu 195 200 Leu Ile Ile Lys Arg Arg. Gn Tyr 210 215 Gin Glu Val Lys Asp Glu Tyr Lys 225 230 Lys Ala Lys Ile Arg Gin Met Met 245 Met Gln Glu Ile Pro Lys Ser Asn 260 Tyr Ala Val Ala Leu Lys Phe Asp 275 280 Val Ala Lys Gly Thr Asp Tyr Leu 290 295 lu Lys T 10 lu Gly A 5 eu Ala G !ly Phe S >he Ser L 7 Thr Phe L 90 ?he Leu S 105 Ile Glu I Leu Phe Val Phe 1 Gly Glu 170 Trp Phe 185 Phe Phe Thr Asn Gin Gin Val Lys 250 Val Val 265 Glu G1u Ala Ile hr Glu L< sn Val P: ly Leu M 4 er Glu M 60 ys Glu S
S
.eu Leu L er Asn V Pro Lys P 1 Ser Leu I 140 Leu Ala 155 Leu Asn Lys Ser Val Leu Ser Leu 220 Glu Gly 235 Asn Ala Val Thr His Pro Arg Ile 300 eu ro et 5 et er eu al he .25 ys Phe His Lys Ala Lyi As Th As Va 28 Ly Pro Si 1' Lys S Ser I Tyr A Val G Leu P 9 Leu G 110 Ser I Lys Phe I Ala Ala 190 L Phe i Met n Pro r Asn n Pro 270 1 Pro *s Gly er er le rg in ro 5 In ,ys le Leu Ala 175 Let Th Gl Ly 25 Th Va
II
Ala.
Met- Phe His Glu Val Phe Ile Leu SGly 160 Leu Trp l Asp r Lys u Ile 240 s Met 5 r His .1 Val ,e Ala Arg Glu His 305 Asp Ile Glu 310 Ile Ile Glu Asn Lys 315 Thr Leu Ala Arg APJ'FW;l
SHFFT
PCT/US 96/0912.2 IPEAUS 18 DEC1996 1109 Leu Tyr Arg Asp Val Lys Leu Asn Ala Thr Ile Pro Glu Glu Leu Phe 325 330 335 Glu Ala Val Ala Ile Val Phe Ala Gin Val Ala Lys Leu Glu Gin Glu 340 345 350 Arg Gln Lys Gin Lys Ile Ile Lys Pro Leu 355 360 INFORMATION FOR SEQ ID NO:1553: SEQUENCE CHARACTERISTICS: LENGTH: 181 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...181 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1553 Glu Asn Thr Met Gin Asp Leu Gin His Phe Lys Asn Asp Ile Thr Leu 1 5 10 Ile Leu Ser Lys Asp Arg Leu Asp Thr Tyr Asp Ser Leu Glu Gin Tyr 25 Lys Glu Asn Leu Lys Leu Ile Ser Phe lie Thr Pro Lys Ile Ser Asn 40 Leu Glu Ile Tyr Leu Arg Asn Ala Leu Asp Tyr Cys Leu Thr Gin Ile 55 Lys Gly Ser Glu Trp Val Phe Asn Glu Asn Ser Leu Thr Asp Leu Ile 70 75 Asn Glu Gin Lys Glu Lys Lys Lys Glu Ile Thr His Ser Leu Ile Leu 90 Ser Lys Met Ser Leu Gly Ala Val Val Arg Leu Ile Phe Cys Tyr Lys 100 105 110 Leu GIu Gly Val Ile Leu Asp Leu Arg Ala Tyr Arg Leu Arg Ala Tyr 115 120 125 Tyr His Glu Asn Lys Asp Thr Leu Leu Ile Lys Gly Lys Lys Arg Leu 130 13S 140 Leu Tyr Asn Tyr Ile Lys Ala His Ile Ala Leu Asn Leu Leu Trp Thr 145 150 155 160 Ile Arg Asn Arg Thr Tyr His Trp Glu Asn Leu Leu Lys Ile Gin Pro 165 170 175 Asn Asn Arg Pro Gin 180 INFORMATION FOR SEQ ID NO:1554: SEQUENCE CHARACTERISTICS: LENGTH: 189 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES PUT/US 96/0912 2 IPENUS 18 DEC 1996 1110 (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...189 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1554 Ala 1 Asn Ser Ser Ile Phe Glu Asn Gly Lys 145 Val Lys Asn Gly Cys Glu Thr Leu Ala Ile Asn Leu Ile Phe Leu Ser Val Ser His Leu Thr Lys Glu 100 Tyr Ile His 115 Val Leu Leu 130 Ile Phe Ser Gly Leu Asn Gin Ile Leu 180 Glu Lys Arg 5 Lys Lys Ala Leu Thr Arg Ile Gly Ser 55 Phe Glu Ser 70 Asn Ser Tyr Gin Ala Leu Thr Ser Glu Glu Asn Met 135 Leu Lys Ala 150 Ala His Lys 165 G1u Asn Ile Ile Phe Met Val Met 40 Ala Ile Thr Phe Met 120 Glu Lys Glu Ile Pro 25 Cys Gly Glu Pro Glu 105 Phe Phe Gly Phe Asp 185 10 Ile Leu Ser Gly Leu 90 Arg Ala Phe Ile Lys 170 Ser Leu Gly Lys Tyr Tyr 75 Asp Val Lys Ser Phe 155 Glu Leu Leu Val Asn Ser Gin Asn Arg Lys Val 140 Cys Asn Ile Cys Gly Pro Pro Ile Phe Val Met 125 Leu Val His Val Ala Leu Asp Glu Glu Ile Asn 110 Val Ser Ser Ala Gly Arg Ile Glu Thr Glu Thr Glu Glu Ser His Ile Ser Ser Gin Lys Val Ala Asn His 160 t Lys Val 175 INFORMATION FOR SEQ ID NO:1555: SEQUENCE CHARACTERISTICS: LENGTH: 293 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION 1...293 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1555 Phe Val Leu Ala Cys Asn Arg Leu Leu Ala Arg Thr 1 5 10 Tyr Arg Ile Cys Gly Phe Ala Lys Asn His Pro Phe 25 Glu Ser Gly Gly Val Trp Phe Cys Gly Tyr Ser Thr 40 Arg Phe Ser Gly His Tyr Cys Cys Lys Trp Arg Arg 55 Ser Val Val Asp Giu Thr Lys Pro Phe Thr His Ser 70 75 Leu Lys Ser Glu Ser Gly Pro Phe Phe Arg Leu Asn Asn Gly Ile Gin Lys Asn Gly Arg p I PCT/US 9 6/0912.2.
IPE-ibS 1 DEC 1996 1111 Lys Arg Val Val Gin 145 Lys His Leu Arg Ala 225 Lys Lys Ser Phe Arg Gly Ser Thr Gly Tyr 115 Gin Cys 130 Tyr Phe Arg Arg Ala Arg Arg Phe 195 Arg Lys 210 Lys Ser Deu Pro Arg Lys Glu Arg 275 Arg Asn 290 Phe Ser Leu Phe Gln Ala Ile Gin Leu 100 Phe Leu Lys Tyr Glu 180 Ser Asp Gin Lys Glu 260 Thr Glu Ala Asn Gin Phe Glu Trp Arg Gly Gly 135 Leu Glu Phe 150 Asn Phe His 165 Thr Phe Phe Glu Lys Arg Cys Arg Lys 215 Ser Arg His 230 Ser Arg Ala 245 Lys Asn Ser Ser-Arg Lys Glu Ser Asp 105 Val Pro 120 Asp Leu Asn Phe Ala Val Arg Gin 185 Lys Thr 200 Thr Arg Arg Lys Lys Ile His Gin 265 Arg Lys 280 His Lys Tyr Arg Phe 170 Ser Lys Asn Arg Arg 250 Lys Arg Arg Asn Cys Lys 155 Phe Ile Arg Gin Ser 235 Arg Gly Ala Pro Tyr Arg Asn 140 Lys Gly Lys Ser Ala 220 His Arg Tyr Arg Ser Phe Phe 125 His Arg Gly Leu Lys 205 Arg Phe Lys Gly Lys 285 Val His 110 Lys Gin Ala His Leu 190 Asp Ser Arg Ala Ile 270 Lys Phe Leu Glu His Gly Cys 175 Arg Lys His Arg Ser 255 Thr Lys Asp Phe Ser Ala Tyr 160 Arg Leu Glu Arg Glu 240 Phe Lys Ser INFORMATION FOR SEQ ID NO:1556: SEQUENCE CHARACTERISTICS: LENGTH: 284 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION 1...284 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1556 Gly Glu Thr Thr Met Lys Leu Arg Ala Ser Val Leu 1 5 10 Ile Leu Cys Leu Ile Leu Set Ala Cys Ser Asn Tyr 25 Val Lys Gin Lys Asn His Val Tyr Thr Pro Val Tyr 40 Glu Lys Tyr Ser Glu Ile Pro Leu Asn Asp Lys Leu 55 Phe Met Val Gln Val Lys Leu Pro Asn Tyr Lys Asp 70 75 Asn Lys Gin Val Val Leu Thr Phe Lys Leu Val His 90 Ile Thr Leu Ile Gly Asp Ala Asn Lys Ile Leu Gin 100 105 Phe Gin Ala Asn Gly Ala Arg Ser Asp Ile Asp Phe Ile Gly Val Ala Ala Lys Lys Val Asn Glu Leu Ile Lys Asp Thr Pro Tyr Leu Leu Asp His Ser Lys Lys 95 Tyr Lys Asn Tyr 110 Tyr Leu Gin Pro fl. PCTUS 9 6I0912 lPENUSJ 9%T 199 6 1112 Thr Asn 145 Ser Val Lys Asp Lou 225 Ile G1 u Leu Leu 130 Pro Gin Ser Ala Lys 210 Glu Sor Clii Arg 115 Asn Pro Cly Gin 195 Glu Thr Ser Giu Asn 275 Lys Lys Lou 165 Asn Glu Giu Ser Ile 245 Arg Ile Gly Val 135 Giu Lys 150 G1y Ala Msn Lye Lys Ile Tyr Thr 215 Msn Arg 230 Phe Lys Clii Lys Arg Ser 120 Val Pro Asn Gin Msn 200 Thr Ala Msn Leu Lou 280 Met Gin Thr Val 185 Gin Arg Giy Gly Gin 265 Lau Ala Ser 140 Ph. Asp 155 Msn Lou Msn Giu Tyr Lye Msn Asn 220 Gin Net 235 Lou Msn Giu Arg Gly Lye 125 Msn Val His Val1 Thr 205 Gin Arg Met Ghii Lou Gly Ala 190 Lou Arg Gin Gin Asn 270 Asn Gin Tyr 175 Arg Leu Glu Mna Ala 255 Glu Asp Gly 160 Asp Glu Gin Ile Val 240 Lys Tyr INFORMATION FOR SEQ ID NO:1557: SEQUENCE CHARACTERISTICS: LENGTH: 241 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NME/KEY: misc..featiire LOCATION .241 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1557 Ser Tyr Cys Gin Met Lys Thr Lou Val Lys Asn Thr Ile Tyr Ser Ph.
10 1s Lou Lou Gin Lou Lou Asp Gly Gin Cly Asp Ph. Ile Lou Lou Clii Gin 130 Gly Lye 145 Ciii Thr Lou Asp Glu GlU Lou Sor Lau Gin Leu Ser Sen Vai Lou Ama Thr Tyr Ile Ph. Ser Asp Ala Lou 70 Ala Lou Lou Ciii Asp Val 100 Thr Tyr Met Cys Gly Ile Lys Ilie Glu 150 Lou Lye Ala 165 Met Ala Ciii Asp Ile Thr Sen Cly Lou Lye Gin Thr 55 Asn Lye Ile Lys Son 135 Gin Glu 40 Thr Ile Ala Pho Ile 120 Asp Ciii Thr Msn Gin Ser Pro Sen Lys Lys Ala 7S Msn Pho Ciii 90 Lys Thr Tyr 105 Asn Pro Lou Lys Val Leu Lys Gin Asn 155 Gin Ala Ala Ala Met Asp Val1 140 Ile Val Msn Ii.
Msn Ser Gin 125 Lou Arg Lou Msn Ala Clii Ser 110 Lys Tyr Clii Lys Msn Lys Ile Lou Arg Lou Ph.
Pro Clii Thr Ala Cys Ciii Arg Lou 160 Ala Ser 175 Tyr Gin Ser Asn 170 Ile Cly Cly Thr POT/US 96/0912 2.
IPENUS 18DEC1996 Leu Phe Leu Ser 225 Lys 1113 Ile Thr Ala Ser Gin Thr Leu Val Glu Ser Leu Lys Asn Lys 180 185 190 Ile Lys Gly Ile Lys Lys Leu Met Leu Ala His Asn Lys Val 195 200 205 Asn Tyr Leu Glu Glu Leu Asp Ala Leu Glu Arg Ser Leu Glu 210 215 220 Lys Arg Gin Tyr Leu Gin Glu Arg Gin Ser Ser Lys Ile Ile 230 235 Asn Phe Gin Val 240 INFORMATION FOR SEQ ID NO:1558: SEQUENCE CHARACTERISTICS: LENGTH: 539 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...539 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1558 Ile 1 Ile Pro Ile Gly Gly Ser Ala Ser Asp 145 Asn Leu Ala Leu Val 225 Asn Asn Ser Ile Pro Tyr Val Asn Trp Ser 130 Val Phe Gin Asp Gin 210 Val Leu Lys Phe Val Ser Thr Ile Leu Ala 115 Gly Ser Thr Ile Gly 195 Asn Lys Pro Asn Met Phe Asn Phe Ser Tyr Ser Glu Val 100 Ser Cys Met Lys Ile 180 Leu Asn Gly Asp 5 Leu Asn Val 11e Ala Lys Val Asn Asp Gly 165 Gly Ile Thr Ala Ile Ile Leu Leu Gly 70 Leu Tyr Ala Phe Ser 150.
Gly Ser Trp Ile Asp 230 Ile Val Lys Thr 55 Ala Ser Leu Thr Gly 135 Val Val Ile Leu Ala 215 Ala Ile Ile Pro Ile 40 Asn Ser Thr Asn Ala 120 Trp Leu Glu Thr Ile 200 Met Ala Gly Lys Asn 25 Tyr Lys Gly Pro Thr 105 Ile Asn Asp Asp Ala 185 Gly Leu Val Gln Arg 10 Trp 1 Gin Ser Ser Leu 90 Leu Gin Ala Asn Asn 170 Gin Lys Ala Leu Gly 250 Leu rhr Phe Gly 75 Ala Gly Gly Leou Leu 155 Val Ala Glu Phe Pro 235 Ser Lys Val Ala Lys Thr Pro Phe Ile 140 Ser Lys Ser Phe Ala 220 Ala Tyr Ala Tyr 4 Asp Ser Ser Leu Ala 125 Asn Asn Gly Thr Thr 205 Ala Tyr Leu Ile Cys Ile Ser Leu Trp 110 Leou Lys Lys Asn Asn 190 Ala Leu Gly Asp Asp Met Leu Gly Ala Gly Thr Asn Ile I1e 175 Ile Asn Glu Val Phe 255 Thr Phe Leu Ile Thr Ile Leu Leu Thr Gin Ala Ser Pro Ile Gin 160 Leu Thr Lys Ser Val 240 Val 245 Ser Tyr Leu Ile Tyr Ile Val Phe Gly Ile Phe Val Phe Ile Ser Phe PCT/US 96/091Z2.
IPEA/US 16 DEC1996 1114 Met Glu Ser 305 Ser Phe Pro Leu Met 385 Leu Leu Trp Leu Ser 465 Thr Thr Val Val Lys Tyr 290 Phe Ile Trp Ala Leu 370 Gin Ile Ile Phe Phe 450 Val Ile lie Ser Gly 530 Leu 275 Met Ile Tyr Ala Val 355 Gin Val Ala Val Ile 435 Gly Ala Ala Ile Met 515 Arg 260 Arg Arg Ala Phe Leu 340 Arg Gly Thr Gly Leu 420 Asn Val Ile Ser Glu 500 Asp Val Asp Phe Tyr Gly 325 Asp Ala Leu Ile Ala 405 Asp Asn Leu Gin Leu 485 Ser Gly Gly Ile Val Ala 310 Leu Leu Val Gin Ile 390 Phe Trp Leu Ala Asn 470 Ile Val Ser Ser Gly 295 Gly Ala Val Phe Val 375 Met Ser Phe Phe Leu 455 Ile Thr Asn Arg Asn 280 Gly Phe Gly Leu Ser 360 Ala Arg Gly Lys Ile 440 Leu Asn Leu Ala Met 520 265 Gly Ile Thr Leu Gly Tyr Ala Phe 330 Asn Tyr 345 Asn Val Gly Ile Ile Ser Ile Val 410 Asp Ser 425 Leu Val Ala Phe Gin Gly Phe Ile 490 Ile Val 505 Asp Arg Gin Phe Leu 315 Gly Thr Gly Ser Thr 395 Phe Met Leu Asn Gly 475 Leu Asn Glu Ile Lys 300 Tyr Leu Val Asn Leu 380 Val Pro Lys Ala Leu 460 Leu Lys Thr Arg Asn 285 Met Lys Asn Asn Asn 365 Phe Val Ile Asn Ile 445 Thr Gly Gly Ile Asp 525 270 Ile Ala Ile Gin Ser 350 Ala Ala Val Ala Ile 430 Pro Ile Ile Phe Phe 510 Ala Gly Phe Met Val Ser Tyr 320 Val Leu 335 Ile Leu Pro Ser Ile Phe Lys Pro 400 Val Cys 415 Leu Ile Ile Leu Thr Pro Asp Ser 480 Ile Gf 495 Ser Ser Leu Met Gly Ser Met Phe Lys Gly 535 INFORMATION FOR SEQ ID NO:1559: SEQUENCE CHARACTERISTICS: LENGTH: 256 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION 1...256 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1559 Leu His Arg Ile Ile Ser Cys Asp Ser Ala Trp Arg Thr Asn Leu Val 1 5 10 Val Arg Thr Asn Lys Ala Leu Tyr Gin Phe Ile Leu Arg Ile Ala Gin 25 Lys Asp Asn Phe Ala Ser Ala Tyr Leu Thr Val Lys Leu Glu Tyr Pro 40 Gin Arg His Glu Val Ser Ser Val Ile Glu Glu Glu Leu Lys Lys Arg 55 PCTUS 96/0912? IPEA/US 1Id DEC 1996 1115 Glu Glu Ala Lys Arg Gin Arg Giti Lou Ile Thr Ile Gin Asn Ser 145 Gin Met Lys Gly 225 Gly Thr Ala Asn Lys Ala Lys 115 Pro Val 130 LYS His Phe Gly Pro Asp Thr Asn 195 Phe Lys 210 Tyr Gly Glu Lou Giu 100 Ala Pro Ile Phe G ly 180 Ser Lou Lys Glu Ile Asn Arg 85 Lys Ile Arg Lou Giu Thr Arg Asn Tyr 135 Met pro Ser 150 Lys Asn Ile 165 Lys Leu Ser Gly Lou Arg Ile Lys Asp 215 Asn Pro Lou 230 Arg Vai Ile 245 Glu Gin 120 Asn Glu Thr Met Trp 200 Lys Giu 105 Tyr Tyr Ile Leu Thr 185 Tyr Ala Met 90 Lys Val1 Tyr Phe Gin 170 Asp Arg Lou
LYS
75 Ala Gin His Gin Asp Pro Ala Val1 Val Gin Giu Ser Asn Lys Ile Asn Ala 125 Ala Pro 140 Asp Gly Ala Ile Ala Ile Asn Glu 205 Thr Val 220 Asn Ile Lou Val Asn Glu Ile 110 Lou Giu Thr Ph.
Asp 190 Ile Ile Lys Arg Lou Gin Lou Lys Lys Ph.
Val 175 Pro Ala Asn Asn Asp 255 Asn Ile Asp Arg Arg Thr 160 Val Asn GlU Lys Tyr 240 Lys Thr Lys Asn Tyr 23S Lys Lys Lou Pro 250 INFORMATION FOR SEQ ID NO:156O: SEQUENCE
CHARACTERISTICS:
LENGTH: 121 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/ KEY misc_feature LOCATION 1 121 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:156O Thr Ser Sen Ph. Lys Thr Lys Met Lys Arg Pro Ile 1 5 10 Gin Asn Ph* Lou Gin Ph. Lys His Sen Ph* Asn Lys 25 Tyr Ser Lou Tyr Tyr Arg Lou Ph. Asn Ile Ser Sen 40 Ph. Lou Ile Ala Lou Ph. Sen Tyr Gly Ala Gly Val 55 60 Pro Ile Leu Ph. Lou Phe Ala Lou Ile Ile Lys Pro 70 75 Tyr Thr Thr Tyr Lou Lou Lou Lou Val Ser Lou Ser 90 Tyr Tyr Lou Lou Son His Ala Asn Pho Thr Met Lys 100 105 Met Thr Gin Trp Gin Asn Trp Ph. Lou 115 120 ser His Ile Ile Sen Ile Lou Lys Lou LYS Lou Asp LYS Val le Gly Lou Val 'Tyr Ph. Ph. Tyr Ile Sen LYS Ile met Lou 110 INFORMATION FOR SEQ ID NO:1561: PCT/US 96/09122 IPEA/US l DEC 1996 1116 SEQUENCE CHARACTERISTICS: LENGTH: 131 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...131 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1561 Val Cys Tyr Cys Glu Met Leu Pro Thr Lys Thr Arg Ile Arg Asp Pro 1 5 10 s 15 Asn Lys Gin Glu Leu Thr Gin Pro Lys Ile Lys Gly Leu Ser Met Gly 25 Lys Ile Leu Ala Ser Leu Leu Gly Gly Gly Thr Asn Leu Phe Thr Gly 40 Leu Ser Ser Asp Leu Phe Ser Met Ile Leu Asn Phe Leu Phe Phe Leu 55 60 Met Leu Met Met Gly Leu Asn Glu Ala Leu Gly Lys Lys Phe Asn Lem 70 75 Pro Met Asp Asn Ile Lys Asn Phe Met Ala Glu Val Leu Lys Asn Gly 90 Phe Asp Ser Ile Lys Asn Met Gly Ser Ala Leu Val Gly Asn Gly Phe 100 105 110 Gly Ser Ser Lys Ser Asp Lys Thr Thr Asn Lys Met Ser Val Pro Gin 115 120 125 Val Arg Leu 130 INFORMATION FOR SEQ ID NO:1562: SEQUENCE CHARACTERISTICS: LENGTH: 297 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM; Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION 1...297 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1562 Glu Glu Leu Leu Met Gly Gin Ala Phe Phe Lys Lys Ile Val Gly Cys 1 5 10 Phe Cys Leu Gly Tyr Leu Phe Leu Ser Ser Ala Ile Glu Ala Val Ala 25 Leu Asp Ile Lys Asn Phe Asn Arg Gly Arg Val Lys Val Val Asn Lys 40 PO/US 96/09122.
IPENUS I Lutfl,996 1117 Lys Ile Leu Asp Tyr Ile Asn His Giu Lys Phe Leu 130 Leu Glu 145 Gin Ala Arg Ala Asn Pro Gin Gin 210 Gin Giu 225 Lys Lys Ser Ilie Giu Leu Pro Ilie -290 Ala Msn Thr Ile Giu 115 Lys Giu Gin Lys Gin 195 Arg Gin Gin Lys Ser 275 Lys Val Thr Phe 100 Ala Thr Gin Lys Asn 180 Asn Giu Ala Ala Thr 260 Pro Pro Leu Thr Gly Ile Val
LYS
Lys Aia 165 Arg Leu Asn Gin Giu 245 Asp Ala Cys Gly Val 70 Ph.
Gin Msn Lys Lys 150 Gin Ala Ser Giu Ala 230 G iu Lys Ile Ile Asp Ile Asn Pro Phe Leu i3 5 Ala Lys Asn Msn Leu 215 Msn Ala Ser Ala Asn 295 GlU Gin Lys Lys Ala 120 Ile Leu Asp Lou Asn 200 Asp Ala Val Gin Leu 280 Ser Lys Lou Gly Ser 105 Lou Val Giu Lys Giu 185 Lys Gin Lou Arg Lys 265 Pro Giu Trp 90 Val Met Asp Lys Arg 170 Asn Asn Met Lys Gin 250 Ser Ile Lye 75 Ser Lys Thr Ala Giu Giu Lou Lou Giu Gin 235 Arg Pro Thr Ile Asp Giu Ile Val Sor Asn Arg Asp 125 Pro Asp 140 Lys Giu Lys Arg Thr Asn Ser Giu 205 Arg Lou 220 Ile Giu Ala Lys Giu' Asp Trp Thr Pro Lou 110 Tyr Pro Ala Lys Ala 190 Lou Glu Giu Asp Asn Thr Ile Msn Met Gin Lys Lys Gilu 175 Met Ile Lou Lys 255 Ser Ser Ser Ser Phe GiU Giu Giu 160 Glu Ser Lys Met An 240 Ile Ile Lou Cys Gly Gly Gly Lou 1ie Lou 285 Ph.
INFORMATION FOR SEQ ID NO:1563: SEQUENCE CHARACTERISTICS: LENGTH: 255 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAE/KEY: misc..feature LOCATION .255 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1563 Ser Cys Arg Met Lou dly Lys Lye Asn Giu Giu Val 1 5 10 Aen Lou Val Gly Gly Val Ile Ala Lou Asp Arg Lou 25 Lye Ala Asn Arg Thr Phe Lye Arg Ala Phe Tyr Lou 3S 40 Asn Val Ala Ala Val Thr Se Ile Val Met Met Met 55 60 Thr Asp Ile Ph. Val Tyr Gly Ilie Asp Arg Tyr Thr 70 75 Ile Vai Lye Arg Ser Asp Ala Arg Gin Ile Val Asn Lou 116 Ala Lye Sen Met Pro Lou Gly Glu Ser Giu is Lou Val Lye Phe Ala Glu Asn Lou Lys Lys Val1 PCTUS 96/0912? IPENIUS 18DEC 1996 Ilia Val Asp Lys Asri Val Ser 130 Gin Phe 14S Gin Arg Ile Thr Thz Lys Ser Gln 210 Ile Gin 225 Arg LYe Ser Ala 100 Ser Lou 115 Phe Gin Val Asp Giu Lys Ile Lys 180 Lys Gin 195 Glu Msn Ile Thr Ile Lys Thr Arg Thr Lys Val 165 Ile Val Leu Asp Glu 24S Ser Asp Gin Val 150 Lys Thr Thr Ile Lou 230 Val Ph.
Lys 120 Met Ala Ser Asp Tyr 200 Msn Asn Val 105 Asp Arg Glii Pro Thr 185 Tyr Pro GlU 90 Ser Gin Met Ala Leu 170 Met Asp Phe Gin Asn 250 Lou Leu Ph.
Ile 155 Thr Giu Phe Giy Thr 235 Leu Met Asn 140 Ile Arg Asn Ala Ph.
220 Val Phe Gin 125 Giu Set Leu Tyr Arg 205 Lys Set Giy 110 Asn Sor Thr Glu 190 Giy Val Giu Cys Ile Asn Phe 175 Msn Ph.
Ile Lys 255 Ser Asp Arg Ile 160 Phe Ile Ser Asp Lou 240 Glu Ser LYS Lye Ala Leu Asn INFORMATION FOR SEQ ID NO:i564: SEQUENCE
CHARACTERISTICS:
LENGTH: 250 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc..feature LOCATION 1 .250 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:l564- Lys Arg Lou Ile Gin Arg Asp Giu Thr Ile Ala Thr Gin Arg Giu An 1 5 10 is Giy Ile Ii.r Ser Lys Gin Ph. Lou Asn Lou Ile Lou Glu Arg Ser Ph.
25 Met Asn Asp Thr Thr Giu, His His Gly Ser Msn Pro Lou Msn Ala Pro 40 Pro Pro Son Msn Sen Gin Ser Msn Asp Lou Lou Asn Lou Lou Asp Ser s0 5S Lou Tyr Pro Lys Gly San Lou Gly Giu Gin Arg Ph* His Glu. Ala Lou 70 75 Lye Msn Gin Giu Glu Lou Lye Ann Ile Lou Ile Glu Ile Giu Lys Lou 90 Pro Gin Giu Lye Arg Tyr Glu Lou Lou Met Gin Ile Gly Gin Ala Lye 100 105 110 Gin Arg Ile Met Glu Ala Tyr Ala His Ser Phe Lou Gly Tyr Ile Gly 115 120 125 Gly Lou Giu His Lou Lou Gly Lou Cye Met Giy Gly Ile Phe Vat Lou 130 135 140 Ph. Ala Ile Tyr Phe Val Ph. Lou Arg Thr Ser Lye Aen Thr Giu Lou 145 150 155 160 Val Glu Ser Lou Lye Thr Lys Lou Lys Lou Gin Tyr Phe Tyr Tyr Ala 165 170 175 POT/US 96/09122 IPENUS 1i DEC1996 1119 Phe Gly Val Gly Ala Val Leu Phe Phe Gly Leu Glu Thr 180 185 Ile Tyr Glu Leu Tyr Ile Leu Gly lie GlY Ser Thr Asn 195 200 205 Leu Phe Val Leu Lys Asn Ile Cys Phe Ile Gly Met Gly 210 215 220 Tyr Lys Val Ile Lys Val Ile Gly Ile Lys Asn Phe Ile 225 230 235 Phe Ala Ser Lys Lys Gin Gly Gly Ala Glu 245 250 Arg Ser Lys Val Leu Ile Gly Leu 240 INFORMATION FOR SEQ ID NO:1565: SEQUENCE
CHARACTERISTICS:
LENGTH: 382 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...382 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:15 6 Gly Tyr Lys Asn Tyr Lys Met Leu Ala Lys lie Val Phe Ser Ser Leu 1 5 10 Val Ala Phe Gly Val Leu Ser Ala Asn Val Glu Gin Phe Gly Ser Phe 25 Phe Asn Glu Ie Lys Lys Glu Gin Glu Glu Val Ala Ala Lys Glu Asp 40 Ala Leu Lys Ala Arg Lys Lys Leu Leu Asn Asn Thr His Asp Phe Leu 55 Glu Asp Leu Val Phe Arg Lys Gin Lys Ile Lys Glu Leu Val Asp Tyr 70 75 Arg Ala Lys Val Leu Loeu Asp Leu Glu Asn Lys Tyr Lys Lys Glu Lys 90 Glu Ala Leu Glu Lys Glu Thr Arg Gly Lys Ile Leu Thr Ala Lys Ser 100 105 110 Lys Ala Tyr Gly Asp Leu Glu Gin Ala Leu Lys Asp Asn Pro Leu Tyr 115 120 125 Lys Lys Leu Leu Pro Asn Pro Tyr Ala Tyr Val Leu Asn Gin Glu Thr 130 135 140 Phe Thr Gin Glu Asp Lys Glu Arg Leu Ser Tyr Tyr Tyr Pro Gin Val 145 15.0 155 160 Lys Thr Ser Ser Ile Phe Lys Lys Thr Thr Ala Thr Thr Lys Asp Lys 165 170 175 Ala Gin Ala Leu Leu Gin Met Gly Val Phe Ser Leu Asp Glu Glu Gin 180 185 190 Asn Lys Lys Ala Ser Arg Leu Ala Leu Ser Tyr Lys Gin Ala Ile Glu 195 200 205 Glu Tyr Ser Asn Asn Ile Ser Asn Leu Leu Ser Arg Lys Glu Leu Asp 210 215 220 Asn Ile Asp Tyr Tyr Leu Gin Leu Glu Arg Asn Lys Phe Asp Ser Lys 225 230 235 240 Ala Lys Asp Ile Ala Gin Lys Ala Thr Asn Thr Leu Ile Phe Asn Ser 245 250 255 Glu Arg Lou Ala Phe Set Met Ala Ile Asp Lys Ile Ash Glu Lys.Tyr PCT/US 9 6 091?? IPEA/US 1i DEC1996 1120 Leu Asp Ser 305 Asn Tyr Met Ser Arg Val 290 Phe Phe Asn Gin Ala 370 Gly 275 Glu Ala Asp Ile Lys 355 Tyr 260 Tyr Leu Gin Thr Phe 340 Glu Arg Glu Ala Asn Thr Lys Gin 310 Gin Ser 325 Val Asp His Tyr Asn Asn Phe Leu 295 Lys Lys Ser Lys Val 375 Ser 280 Thr Leu Lys Asp Ile 360 Ala 265 Asn Lys Cys Ser Pro 345 Phe Lys Leu Asn Leu Ile 330 Met Asn Asn Leu Phe Leu 315 Leu Met Phe Asn Lys Thr 300 Val Lys Ser Phe Pro 380 Asn 285 Asn Leu Lys Asp Lys 365 Phe 270 Val Gin Asp Thr Lys 350 Thr Glu Lys Lys Ser Asn 335 Thr Val Asp Leu Phe 320 Glu Thr Val INFORMATION FOR SEQ ID NO:15 66 SEQUENCE
CHARACTERISTICS:
LENGTH: 309 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...309 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1566 Lys Phe Ser Glu Val Tyr Phe Ile Met Lys Thr Lys A 1 5 Ala Leu Ile Gly Lys Pro Asn Ala Gly Lys Ser Thr L 25 Leu Leu Asn Ala His Leu Ala Lau Val Ser His Lys A 40 4 Arg Lys Leu Met Lys Cys Ile Val Pro Phe Lys Asp I 55 Glu Ser Gin Ile Ile Phe Leu Asp Thr Pro Gly Leu I 70 Lys Leu Lou Asn Gin Cys Met Leu Ser Gln Ala Leu Asp Ala Glu Leu Arg Val Phe Leu Ala Ser Val His 100 105 Gly Tyr Glu GIu Phe Leu Ser Leu Cys Gln Lys Pro 115 120 Leu Ser Lys Ile Asp Thr Ala Thr His Lys Gln Val 130 135 140 Gin Glu Tyr Gln Lys Tyr Ser Ser Gin Phe Leu Ala 145. 150 155 Ser Ala Lys Lys Ser Gin Asn Leu Asn Ala Leu Leu 165 170 Lys His Leu Ser Pro Ser Ala Trp Leu Phe Glu Lys 180 185 Asp Glu Lys Met Arg Asp Ile Tyr Lys Glu Ile Ile 195 200 Phe Asp Phe Leu Ser Asp Glu Ile Pro Tyr Glu Ser 210 215 220 la Gly Phe Val 15 eu Leu Asn Thr 30 la Asn Ala Thr 15 jys GIu Gly Tyr His His Gin Glu Lys Ala Met Gly 95 Asp Asp Leu Lys 110 His Ile Leu Ala 125 Leu Gin Lys Leu Leu Val Pro Leu 160 Glu Cys Ile Ser 175 Asp Leu Met Ser 190 Arg Glu Ser Leu 205 Asp Val Met Ile I I.1. I POUS 96/0912? 1 PENUS i "D E C1996 Asp 225 Ile Val Val Ser Gin 305 Lys Val Asn Gly Trp 290 Arg Phe Giu Ile Giu 275 Ser Asn Ilie Lys Lys 260 Lys Lys Arg Giu Giu 245 Arg Lys Giu Asp Giu Gin Giy Ph.
Lys 295 1121 Arg Ile Asp Lys Vai 235 Lys Lys Ile Val Ile 250 Thr Asn Aia Arg Leu 265 Leu Msn Leu Gin Vai 280 Ser Leu Gin Lys Leu 300 Tyr Giy Lye Ile 285 Gly INFORMATION FOR SEQ ID NO:1567: SEQUENCE CHARACTERISTICS: LENGTH: 392 amino acids TYPE: amino acid TOPOLOGY: iinear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyiori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .392 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1567 iPh. Lou Ser Leu Ser Lou Ile Giu Arg Ala Lys Gin Tyr Lou Lau Ile Giu 14S Leu Asp Pro Leu 1 eu ksn Lys Cys I10 Asp I10 Lys i3 0 Leu Arg Ph.
Arg Asp 210 Lys Lou Asp Ser Lou Arg Lys 115 Giy Giu Gin Thr His 195 Tyr Pro Alia VIal Ile Tyr His 100 Msn Lys Cys Ph.
Lou
ISO
Lou Lys Asn Lou Tyr Aia Asp Tyr Ser Ph.
70 Lys Lou Tyr Aia Val Msn Gin Arg Lou Val 150 Phe As; 165 Lys Asr Msn Asj Pro Al~ Asp Lys Lys 55 Val Aia
LYS
Ile Tyr 135 Lys Tyr Lou Lys Thr krg ksn 40 Lou Giy Asp 25 Thr Ph.
Gly Asp 10 GiU His Asn Gin Lou Lye Lou Asn Giu His Pro Ser Giy Aia Thr Thr Tyr Ile Lys Met Leu Ph.
Met Arg Lye Ser Nsn Lye Ii.
Ph. Msn Ala Met Lou 120 Lou Ser Leu Ala Asp 200 Ser Ph.
105 Giu Tyr Lys Asp Phe 185 Lou Phe Lou.
Giu Val Met Arg 170 Aia Lys Giu Lin Gin Tyr Ala Lys Lys Sor Lys Val Gly Lou 140 Lye Arg Thr Ph.
Arg 220 Ala is Tyr Lys His Leu Val Ph.
125 Lys Tyr Arg Lys Leu 205 Asn Ala 110 Ile Asp Val Tyr Giu 190 Lys Lys Arg Giu Tyr Met Gij 17 1 S02 Th Cy Lys Lye Ph.
Giu Lou Ala Thr Val Arg 160 Ph.
Lou SLou s Ile 215 Lou Lou Ile Val Ile Lou Gly Giy Lou Arg 1319;230 Lys Cys Giu Vai 235 Lou Asn 240 Ile Lou Ile Giu Lou Lys His Ile Gin Vai Giu Giu Gin Asn Tyr Sor PCT/US 96/09122 IPEA/US 10 DEC1996 1122 Ile Leu Lys Gin 305 Ala Arg Leu Tyr Asp 385 Gin Gly Leu Glu 275 Tyr Phe 290 Asn Ser Gin Ile His Ser Thr Ser 355 Ile His 370 Ser Leu 245 Lys Gly 260 Pro Ser Asn Gly Leu Thr Lys His 325 Phe Ala 340 Arg Ala Thr Thr Ile Glu Arg Leu Ala Leu 310 Tyr Thr Leu Gin Asn 390 Lys Asn Tyr 295 Tyr Lys Leu Gly Glu 375 Lys Glu Ala 280 Leu Asn Gin Ile His 360 His Lys Arg 265 Trp Phe Phe Tyr Tyr 345 Ser Asn 250 Lys Ile Lys Ile Gly 330 Gin Ser Lys Ala Ser Lys Pro 315 Thr Glu Leu Lys Tyr Asp Asp 300 Leu Gly Thr Leu Val 380 Ile Asp 285 Lys Ile Leu Gin Ser 365 Ala Lys 270 Tyr Gin Phe His Asp 350 Thr Leu 255 Lys Arg Lys Lys Leu 335 Leu Lys Val Ser Leu Ser Leu 320 Phe Val Ile Phe INFORMATION FOR SEQ ID NO:1568: SEQUENCE CHARACTERISTICS: LENGTH: 170 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION I...170 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1568 Lys Arg Lys Glu His Cys Met Lys Asn Leu Arg His 1i Ile Thr Gly Asn Glu Ile Leu Asn
IV
Ala Phe Ile 50 Leu Val Ser Ser Ser Phe Phe Leu Asp Pro Ser Gly 115 Phe Leou Asn Met Arg Met Lys 100 Phe Val Gly Ser Val Trp Gin Glu Val Leu Phe Ile Ile Lys 70 Leu Lys Pro Tyr
C
C
er Pro Leu Leu Leu Gin ;lu Gin 40 Phe Leu 55 G3u Ile Val Ala Phe Leu Phe Ile 120 Val Cys 135 Ile Ser Ser Phe 25 Gln Gly Leou Ile Trp 105 Met Phe Leu Leu Met Ser 90 Leou Ile Leu Thr Ala Thr 75 Val Asn Pro Leu Ser Ile Val Ser Ala Trp Ile Phe Arg Lys Leu s15 Ala Asp Met Thr Pro Thr Ala Lys Phe Ile Trp Lys Leu Ala Leu Lys Asn Leu Lys Glu Lys Ser Phe Leu 110 Leu Asp Ile Leu 125 Phe Ser Ile Ala 140 130 Glu Phe Phe Asp 145 Ile Lys Thr Lys Glu Asp 150 Ala Asn 165 Asp Ile Leu 155 Tyr Ala 170 Ile Ala His Ser Lys 160 PCT/US 96/09122.
IPEA/US C 1123 INFORMATION FOR SEQ ID NO:1569: SEQUENCE
CHARACTERISTICS:
LENGTH: 209 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION 1...209 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1569 Lys Ser Arg Asn Phe Ser Tyr Asn Gin Thr Glu Lys Ile Trp Giu Asn 1 5 10 His Phe Asn Leu Phe Ser Val Gly Ile Gly Met Ala Glu Glu Gin Glu 25 Asn Thr Ala Gln Gln Pro Gin Lys Lys Ser Lys Ala Leu Leu Phe Val 40 Ile Ile Gly Ser Val Leu Val Met Leu Leu Leu Val Gly Val Ile 11e 55 Met Leu Leu Met Gly Asn Lys Glu Glu Ser Lys Glu Asn Ala Ser Lys,, 70 75 Asn Thr Gln Glu Val Gin Ala Asn Pro Met Ala Asn Lys Asn Gin Glu 90 Ala Lys Glu Gly Ser Asn Ile Gin Gin Tyr Leu Val Leu Gly Pro Leu 100 105 110 Tyr Ala Ile Asp Ala Pro Phe Ala Val Asn Leu Val Ser Gin Asn Gly 115 120 125 Arg Arg Tyr Leu Lys Ala Ser Ile Ser Leu Glu Leu Ser Asn Glu Lys 130 135 140 Leou Leu Asn Giu Val Lys Val Lys Asp Thr Ala Ile Lys Asp Thr Ile 145 150 155 160 Ile Giu Ile Leu Ser Ser Lys Ser Val Glu GIu Val Val Thr Asn Lys 165 170 175 Gly Lys Asn Lys Leu Lys Asp Glu Ile Lys Ser His Leu Asn Ser Phe 180 185 190 Leu Ile Asp Gly Phe Ile Lys Asn Val Phe Phe Thr Asp Phe Ile Ile 195 200 205 Gin INFORMATION FOR SEQ ID NO:1570: SEQUENCE CHARACTERISTICS: LENGTH: 183 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: AAmtnrn wrcrT PCT/US 96/0912.2.
IPEANUS 18 DEC1996 1124 NAME/KEY: misc_feature LOCATION 1...183 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1570 Gly Ser Met Met Thr Glu Met Glu Leu Lys Leu Ile Lys lie Asp Thr 1 5 10 Ser His Tyr Phe Glu Lys Lys Pro Gly Leu Gly Glu Arg Met Asp Tyr 25 Ala Gly Arg Cys Tyr Tyr Asn Lys Phe Gin Arg Val Asn Ala Met Leu 40 Thr Ser Ser Leu Ile Gin Lys His Leu Lys Arg Glu Ile Glu Ile Ala 55 His Asn Leu Ile Leu Arg Asn Asp Lys Val Glu Asn Ile Val Phe Asp 70 75 Tyr Asn Gly Arg Asn Pro Glu Arg Phe Tyr His Lys Ala Gin Leu Leu 90 Leu Arg Glu Glu Gly Phe Met Asn Phe Thr Ala Tyr Asn Thr Lys Thr 100 105 110 Pro Gly His Leu His Leu Tyr Val His Lys Gly His Thr Glu Leu Gly 115 120 125 Glu Gly Glu Arg Leu Ile Lys Thr Leu Ser Met Lys Leu Ala Gin Gly 130 135 140 Leu Pro Lys Glu Trp Arg Val Phe Pro Ser Asn Glu Trp Pro Lys Glu 145 150 155 160 Phe Asn Ile Leu Ala Leu Pro Tyr Glu Val Phe Ala Lys Glu Arg Gly 165 170 175 Ser Ser Trp Ala Lys His Leu 180 INFORMATION FOR SEQ ID NO:1571: SEQUENCE CHARACTERISTICS: LENGTH: 275 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION 1...275 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1571 Pro Phe Leu Lys Gly Phe Leu Met Ser Glu Lys Glu Arg Leu Asn Glu 1 5 10 Val Ile Leu Glu Glu Glu Asn Asn Gly Ser Gly Thr Lys Lys Val Phe 25 Leu Ile Val Ala Ile Ala Ile Ile Ile Leu Ala Val Leu Leu Met Val 40 Phe Trp Lys Ser Thr Arg Val Ala Pro Lys Glu Thr Phe Leu Gin Thr 55 Asp Ser Gly Met Gin Lys Ile Gly Asn Thr Lys Asp Glu Lys Lys Asp 70 75 Asp Glu Phe Glu Ser Leu Asn Met Asp Ser Pro Lys Gin Glu Asp Lys 90 Leu Asp Lys Val Val Asp Asn Ile Lys Lys Gin Glu Ser Glu Asn Ser 100 105 110 ^irf U F PCT/US 9 6 091 PUS i .i1996 1125 Met Pro Ile Gin Thr Asp Gin Ala Gin Met Glu Met Lys Thr Thr Glu 115 120 125 Glu Lys Gin Glu Ser Gin Lys Glu Leu Lys Ala Val Glu Pro Ile Pro 130 135 140 Met Ser Thr Gin Lys Glu Ser Gin Ala Val Ala Lys Lys Glu Thr Pro 145 150 155 160 His Lys Lys Pro Lys Val Ala Pro Lys Asp Lys Glu Ala His Lys Asp 165 170 175 Lys Ala Lys His Ala Ala Lys Glu Pro Lys Val Lys Lys Glu Ala Arg 180 185 190 Lys Glu Val Ser Lys Lys Ala Asn Ser Lys Thr Asn Leu Thr Lys Gly 195 200 205 His Tyr Leu Gin Val Gly Val Phe Ala His Thr Pro Asn Lys Ala Phe 210 215 220 Leu Gin Glu Phe Asn Gin Phe Pro His Lys Ile Glu Asp Arg Gly Ala 225 230 235 240 Thr Lys Arg Tyr Leu Ile Gly Pro Tyr Lys Ser Lys Gin Glu Ala Leu 245 250 255 Met His Ala Asp Giu Val Ser Lys Lys Met Thr Lys Pro Val Val Ile 260 265 270 Glu Val Arg 275 INFORMATION FOR SEQ ID NO:1572: SEQUENCE CHARACTERISTICS: LENGTH: 189 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc.feature LOCATION 1...189 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1572 Ser Arg Leu Gin Lys Ala Ile Ile Lys Arg Val Glu Met Leu Glu Lys 1 5 10 Leu Ile Glu Arg Val Leu Phe Ala Thr Arg Trp Leu Leu Ala Pro Leu 25 Cys Ile Ala Met Ser Leu Val Leu Val Val Leu Gly Tyr Val Phe Met 40 Lys Glu Leu Trp His Met Leu Ser His Leu Asp Thr Ile Ser Glu Thr 55 Asp Leu Val Leu Ser Ala Leu Gly Leu Val Asp Leu Leu Phe Met Ala 70 75 Gly Leu Val Leu Met Val Leu Leu Ala Ser Tyr Glu Ser Phe Val Ser 90 Lys Leu Asp Lys Val Asp Ala Ser Glu Ile Thr Trp Leu Lys His Thr 100 105 110 Asp Phe Asn Ala Leu Lys Leu Lys Val Ser Leu Ser Ile Val Ala Ile 115 120 125 Ser Ala Ile Phe Leu Leu Lys Arg Tyr Met Ser Leu Glu Asp Val Leu 130 135 140 Ser Ser Ile Pro Lys Asp Thr Pro Leu Ser His Asn Pro Ile Phe Trp 145 150 155 160 Gin Val Val Ile His Leu Val Phe Val Cys Ser Ala Leu Leu Thr Ala AP4~'~v~r4 ~4I&~ POT/US 9 6/0912.
IPIBEA DEC 1996 1126 165 170 Val Thr Asn Asn Ile Ala Phe Ser Gin Lys Glu Arg His 180 185 INFORMATION FOR SEQ ID NO:1573: SEQUENCE
CHARACTERISTICS:
LENGTH: 237 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...237 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1573 Gly I 1 Gly I Leu C Val C Met Phe Gly Lys Asp Phe 145 Val Asp Asn Asp Thr 225 Leu I Ile Sly ly rhr Phe Leu Thr Leu 130 Pro Lys Glu Lys Leu 210 Pro Asn krg Ile Asn Asn Leu Gly Phe 115 Met Thr His Val Ala 195 Pro Pr Tyr I 5 Gly PI Val L4 Leu P] Leu I Ala L 8 Ile I 100 Leu V Lys A Met L Val G Lys 180 Thr Lys o Ile le Asp Leu Ala Leu Leu Val Val Val Val Ala Phe he eu he le eu 5 le al sp ,ys ,lu .65 snr As Pr Tyr His Gly Gly Val Tyr 40 Ser Glu His 55 Gly Phe Leu 70 Gly Val Leu Asp Lys Ala Leu Ser Phe 120 Ala Asn Ala 135 Ser Val Ala s150 Lys Asn Leu Lys Gly Ser Lys Gly Val 200 i Met Leu Glu 215 o Thr Pro Ser 230 10 Phe Va 25 Leu Al Leu Ty Leu Va Leu Gl 90 Leu Gl 105 Ile Le Tyr Li Ser L) Lys A4 Ile A! 185 Glu A 1 a r 1 y y Iu eu ys sp 70 sp la Ser Ser Asp Leu 75 Lys Phe Tyr Gin Ile 155 Asn Asn SLeu Glu Arg Leu Ala Met Ile Ala Glu 140 Met Leu Ala Lys Ile Ala Tyr Ser Arg Asn Ser Ile Leu Val Phe Ser 110 Leu Ser 125 Lys Ser Arg Leu Glu Glu Lys Glu 190 Glu Lys Ala Val Glu Trp Phe 95 Cys Lys Ala Asp Met 175 Ser Ala Thr Ala Thr Val Ser Leu Met Ile Gly 160 Ser Phe Lys i Gin Pro Lys His Asn Lys Glu 235 205 Asn Lys Pro As 220 Pro Leu INFORMATION FOR SEQ ID NO:1574: SEQUENCE CHARACTERISTICS: LENGTH: 395 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein I2EAUS b0 0.U 6 1127 Ser iii) HYPOTHETICAL: YES (vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION .395 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1574 Leu Trp Val Giu Asn Pro Ile Lou Lou Ser His Ser Gin Val Tyr 1A 15 Ser Pro Ala Leu Arg Leu Leu Val Giu Asn His Pro Ser Val Cys Ile 130 Val Lou 145 Asp Leu Gin Asp Ile Lou Val Phe 210 Pro Gly Ser Ala Pro Phe Phe 115 Ph.
Lou Lys Lou Lys 195 Pro Arg Phe His Lou Tyr Gly 100 Ang Leu Leu Glu Lys 180 Giu Giu cys Phe Ser Val Phe 85 Phe Val Ser Leu Val 165 Ph.
Trp Val Asp Tyr 70 Arg Asp Asp Ala Gly 150 Gly Asp Val Gly Phe 55 G ly Leu Trp Lys Gin 135 Ala Asn Ser Phe Ala 40 Thr Val Lou Lou Lou 120 Asn Lou Ile Asn Ala 200 Pro 5 r Lys as 25u yr Lou Ser Val los Ser Lou Asp Glu Tyr 185 Gin 11e Thr Pro Arg Asn Ser Ala Phe Lou Leu Phe Phe 90 Pro Lou Lys Phe Leu 170 Lou Ser Ala Ile Lys Leu Thr Ala Ty1 21 Phe Ty Lou Pr 60 Tyr Le Lou G Asp Se Gly L4 Lys T His P Val S Asn A Lys G Lou G 2 Ile A 235 Asn S s Val U Gin r Arg e Arg 315 r Ser 0 r Pro a Arg Br Tyr rg Ser 395 r Trp o Leu u Lou y Ser r Phe mu Ile %125 (r Arg 40 he Phe er Thr sn Ile cys Ile Leu Ser Phe 110 Phe Met Lys Arg Glu 190 Ala Ile Tyr Phe 95 Ser Leu Ile Ile Thr 17S Asn Lou Val Phe Ile Tyr Ala G1)( Ser 160 Pro Asn Lys Thr Gin Lou 225 Thr Lou Arg Ala Ser Lys Lys Ser 260 Gly Glu 11 Met 27 S Leu Phe Ph* Gly 290 Ser Asp Phe Thr 305 Giu Gly Thr Ser Ile Lou Met Ser 340 Lou Gin Arg Thr 355 Ile Leu His Ser 370 Lou Lou Gly Asp 385 ;lu Gin 245 Val Pro Giu Lou Lys 325 Asr Let Al Il Asp Lou S 230 Gly Tyr Gin Ile Lou Pro Ser Ala 295 Asp Asp 310 Pro Ala Asn Ala Lou Lys x Asn Phe 375 e Lou Phe 390 or Ser Ala G1u 280 Tyr Phe Tyr Trp Tyr 360 Sex Ar Ala Lou Asp 265 Phe Lou Thr Ser Phe 345 Tyr Thr g Lys Lys
TS(
Le Ty Ph So 33 So Al
S
A
1n lu or le Lys Asn 300 Pro Pro Sex Ar 1I 38 Lys Thr Lou Ile 205 Asn Ser Pro Ph*- Ite Lou Ile Gly 240 Ser Ph* Lou Phe 255 Lou Ala Pro Ph* 270 Pro Lou Glu Lys 285 Ala Pro His Phe Lou I1 Cys Tyr 320 Ser Lys Val Ph.
335 Ile Giu Pro Thr 350 g Tyr Asp Lys Ile 365 e Lou Ser Pro Ser 0 INFORMATION FOR SEQ ID NO:1575: Ai4~D HEET, PCTUS 9 6/0912 IPAU 13. D)C 1996 1128 SEQUENCE CHARACTERISTICS: LENGTH: 216 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobactor pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .216 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1575 Giu Thr Ile Met Ile Lys Ala Ile Asp Ile Ser His Ala Phe Giu Lys 1 5 10 Pro Lou Tyr Asn Gly Val Asn Leu Arg Ile Lys Pro Lys Giu Ser Leu 25 Ala Ile Leu Gly Val Ser Gly Ser Gly Lys Ser Thr Lou Leu 5cr His 40 Lou Ala Thr Met Lou Lys Pro Asp Ser Gly Thr Val Ser Leu Lou Glu 55 His Gin Asp Ilie Tyr Ala Leu Asn Sor Lys Lys Lou Lou Giu Lou Aig 70 75 80 Arg Leu Lys Val Gly Ile Val Phe Gin Ser His Tyr Lou Ph. Lys Gly 90 Ph. Ser Aia Leu Giu Asn Lou Gin Val Ala 5cr Ile Leu Ala Lys Gin 100 105 110 Giu Ilie Asn His Ser Lou Leu Giu Gin Lou Gly Ile Ala His Thr Lou 115 120 125 Lys Gin Gly Val Gly Glu Lou Ser Gly Giy Gin Gin Gin Arg Lou Ser 130 135 140 Ile Ala Arg Val Lou Ser Lys Lys Pro Gin Ile Ile Ile Ala Asp Glu 145 150 155 160 Pro Thr Gly Asn Lou Asp Thr Thr Ser Ala Asn Gin Val Ile 3cr Met 165 170 175 Lou Gin Asn Tyr Ilie Thr Glu Asn Giu Gly Ala Lou Val Lou Ala Thr 180 185 190 His Asp Glu His Lou Ala Phe Thr Cys Sor Gin Val Tyr Arg Lou Glu 195 200 205 Lye Giu Ser Lou Ile Lye Giu Lys 210 215 INFORMATION FOR SEQ ID NO:1576: SEQUENCE CHARACTERISTICS- LENGTH: 61 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc-feature, 9 91g 2.
IPENUS i oDC 1996 1129 LOCATION 1...61 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1576 Ser Leu Ala Pro Lys Leu Lys Ala Phe Phe Lys Val Ala Leu Ser Cys 1 5 10 Lys Ala Val lie Lys Ile Thr Gly Val Glu lie Lys Lys Ser Phe Leu 25 Met Arg Leu Asn Asn Ser Lys Leu Phe Ile Ser Gly Thr Cys Thr Ser 40 Lys Ser Lys Arg Leu Lys Arg Ser Thr Glu Ser Leu Ser 55 INFORMATION FOR SEQ ID NO:1577: SEQUENCE CHARACTERISTICS: LENGTH: 300 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION 1...300 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1577 Phe Ala Leu His Lys Lys Val Leu Leu Ala Leu Thr Ala Ser Leu Ile 1 5 10 Cys Gin Glu Ser Leu Phe Ala Lys Asp Lys Asp Tyr Thr Leu Gly Lys 25 Val Ser Thr Ala Gly Lys Lys Asp Arg Ser Asp Tyr Ser Gly Gin Val 40 Asn Leu Gly Tyr Ser Gly Ile Thr Ala Pro Lys Ser Trp Gin Asp Glu 55 Glu Val Lys Lys Tyr Thr Gly Ser Arg Thr Val Ile Ser Asn Lys Ala 70 75 Leu Thr Gin Gin Ala Asn Gin Ser Ile Glu Glu Ala Leu Gin Asn Val 90 Pro Gly Leu Gin Ile Arg Asn Ala Thr Gly Val Gly Ala Met Pro Thr 100 105 110 Ile Gin Ile Arg Gly Phe Gly Ala Gly Gly Ser Gly His Ser Asp Ala 115 120 125 Thr Leu Met Leu Val Asn Gly Ile Pro Val Tyr Met Ala Pro Tyr Ala 130 135 140 His Ile Glu Leu Asp Ile Phe Pro Val Thr Phe Gin Ala Ile Asp Arg 145 150 155 160 Ile Asp Val Ile Lys Gly Gly Gly Ser Val Gin Tyr Gly Pro Asn Thr 165 170 175 Tyr Gly Gly Ile Val Asn Ile Ile Thr Lys Pro Ile Pro Asn Gln Trp 180 185 190 Glu Asn Gin Ala Ala Glu Arg Ile Thr Tyr Trp Ala Lys Ala Arg Asn 195 200 205 Ala Gly Phe Ala Ala Pro Pro Asp Lys Thr Gly Asp Pro Ser Phe Ile 210 215 220 Lys Ser Leu Gly Asn Asn Leu Leu Tyr Asn Thr Tyr Val Arg Ser Gly 225 230 235 240 Gly Met Ile Asn Lys His Val Gly Ile Gin Ala Gin Ala Asn Trp Val A~at~u~v-r~ c~u~r PUT/US 96/09 2.
PEVUS i u 6.G 1996 1130 Arg Trp Tyr 245 250 255 Gly Gin Gly Phe Arg Asp Asn Ser Pro Ser Ser Ile Ser Asn Tyr 260 265 270 Leu Asp Gly Val Tyr Asp Ile Asn Glu Ser Asn Gly Ile Lys Ala 275 280 285 Tyr Gin Tyr Tyr Asp Phe Ala Ile Ala Gin Pro 290 295 300 INFORMATION FOR SEQ ID NO:1578: SEQUENCE CHARACTERISTICS: LENGTH: 275 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION .275 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1578 Val S 1 Glu I Cys Pro Phe Ala Ile Thr Asp Glu 145 Lou Lys Gly Thr Leu 225 Gly Lys ;er Ser Leu Lys Thr4 Asp Ala Ala Lou 130 Tyr Ser Lys Gly Lys 210 Asn Lys Ser le Val Gly G1u Arg Gly Arg Thr 115 Ala Tyr Ala Asp Cys 195 Asp Asp Gly Cys Leu Val I 5 Met Leu C Ala Lou Lou Ile Ala Lys Cys Ala Giu Asn 100 Ala Lys Glu Phe Ser Lys Thr Phe 165 Lou Giu 180 Ser Lys Phe Lys Ala Lys Val Ala 245 Lys Leu 260 le Ile Giu
I
ly Ser :ys ?he Lys 70 Ile Ala Val Tyr Ser 150 Tyr TyV Leu Lys Gly 230 Leu Ser 55 Tyr Leu Arg Cys Phe 135 Cys Asn Tyr Gly Ala 215 Cys Val Cys 40 Gly Phe Arg Giu Lys 120 Asn.
Lys Asp Ser Gly 200 Phe Tyr Pro Lys as Gly Ile G1u Giu Ser 105 Lou Val Lou Met Lys 185 AsS
G
Al Tyr 10 Lys Gly Thr Lys Val 90 Ile Asn Asn Asr 1le 170 Ala Tyl u Tyi i Le S Gl Thr Phe Tyr L Ala Val Phe A 3 Lou Met Ala G 45 Ile Tyr Thr P Ala Cys Lys S 75 Tyr Ser Ser C Giu Lys Ala Asp Ala Glu 125 Asp Lou Lys 140 Asn Val Glu 155 Lys Gly Lou Cys Glu Lou r Phe Phe Gly 205 n Ser Ala Lys 220 u Ala Ala Phe 235 n Thr Thr Giu ys rg 0 lu
ISP
Ser ly Leu 110 Lys Asn Gly Lys Ar 19C Gi1 Al Ty As Arg G 15 Val L Gin P Lys Asn Lys Glu Cys Ala Cys Lys 175 Asn.
Gly L Cys SAsn n Lou 255 iu eu sp Asn Asp Ala (is
LYS
Lou Met 160 Asp Gly Val Giu Giu 240 Glu Lys Asp Glu Ly 250 Ala Cys Asp Ile Gly Lou Lys Giu 265 Lou Lys Glu 270 Gin Lys Gin 275 AEACVM 'M CUCL"r |ZiAS 1
C
0 1996 1131 INFORMATION FOR SEQ ID NO:1579: SEQUENCE
CHARACTERISTICS:
LENGTH: 139 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...139 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1579 Thr Arg Lys Ser Ser Ala Ser Met Ser Glu Asn Glu Lys His Pro His 1 5 10 Arg Val Leu Gln Leu Ile Lys Ser Ser Gly Ile Thr Pro Gly Ile Val 25 Leu Asn Pro His Thr His Glu Glu Ser Ile Lys Tyr'Leu Leu Glu Se 40 45 t Val Gly Leu Val Leu Leu Met Ser Val Asn Pro Gly Phe Gly Gly Gin 55 Lys Phe Leu Asp Leu Val Leu Glu Lys Cys Leu Lys Val Lys Glu Leu 65 70 75 Ile Lys Arg Tyr Asn Pro Ser Cys Leu Leu Glu Val Asp Gly .Gly Val 90 Asn Asp Lys Asn Ile Phe Glu Leu Gin Gln Ala Gly Val Asp Val Val 100 105 110 Val Ser Gly Ser Tyr Ile Phe Glu Ser Lys Asp Arg Lys Leu Ala Ile 115 120 125 Glu Gly Leu Gin Asn Val Arg Gin Pro Leu Ala 130 135 INFORMATION FOR SEQ ID NO:1580: SEQUENCE
CHARACTERISTICS:
LENGTH: 315 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:.YES (vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...315 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1580 Lys Leu Leu Arg Val Leu His Lys Met Ile Lys Lys Ala Ala Lys Thr 1 s 10 Pro Phe Phe Lys Ile Leu Phe Gin Ala Leu Ser Tyr Asn Ile Arg Met PCT/US 96/0912..
1132 Lys Gin Thr Asp Cys Ala Leu Lys 145 Ile Lys Pro Gly Leu 225 Gin His Lys Leu Leu 305 Asp Asn Leu Gly Leu His Ser 130 Gin Gly Lys Phe Ser 210 Ser Arg Glu Ala Leu 290 Leu Leu Ala Leu Ala Gly Asn 115 Ala Asn Asn Ala Asn 195 Thr Gin Pro Asp Asn 275 Gin Trp Asn Leu Glu Lys Gly 100 Lys Val Arg Thr Leu 180 Thr Ala Ser Leu Ala 260 Gin Lys Gly Lys Thr Phe Lys Asp G1u 70 Asp Ala Asp Gly Pro Cys Glu Leu Ile Lys 150 Ser Phe 165 Gly Val Tyr Lys Tyr Asn Tyr Ile 230 Val Leu 245 Leu Val Pro Leu Asn Ser Glu Ser 310 Ile Gly 40 Glu Leu 55 Gly Phe Gin Leu Thr Ile Phe Gly 120 Asn Gly 135 Leu Glu Tyr Ala Leu Asp Gly Asp 200 Leu Ser 215 Leu Thr Gly Ala Val I1e Tyr Ile 280 Arg Asp 295 Pro Asn 25 Val Glu Glu Ile Leu 105 Val Leu Glu Ile Ile 185 Gly Ala Pro Glu Asp 265 Gin Tyr Lys Phe Val Arg Gln Ser Lys 90 Gly Arg Lys His Asn 170 Lys Leu His Leu Phe 250 Gly Lys Phe Lys Ala Phe 75 Lys Ala Ile Asp Leu 155 Glu Ala Ile Gly Cys 235 Cys Gin Ser Lys Arg Lys Met Ala Leu Gly Phe 140 Ala Ile Cys Ile Pro 220 Asp Leu Ala Pro Val 300 Pro Glu Ile Tyr Arg Asn 125 Leu Leu Val Ala Ala 205 Ile Phe Ser Thr Thr 285 Leu Thr Trp Asp Ala Met 110 Leu Gin Glu Ile Gly 190 Thr Val Ser Phe Tyr 270 Thr Lys His His Val Leu Ser Leu Phe Leu Thr His Gly Phe Asp Leu Gly Arg 160 Ala Lys 175 His Thr Pro Leu His Ala Leu Thr.
240 Cys Ala- 255 Asp Leu Thr Lys Glu Lys INFORMATION FOR SEQ ID N0:1581: SEQUENCE CHARACTERISTICS: LENGTH: 218 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION 1...218 (xi) SEQUENCE DESCRIPTION: SEQ ID N0:1581 Arg Tyr Asn Thr Pro Met Gin Lys Lys Ile Phe Leu Leu Glu Asp Asp 1 5 10 s 15 Tyr Leu Leu Ser Glu Ser Ile Lys Glu Phe Leu Glu His Leu Gly Tyr 25 Glu Val Phe Cys Ala Phe Asn Gly Lys Glu Ala His Glu Arg Leu Ser 40
A?
POT/US 96/0912.2.
IPEAu. "i996 1133 Val Glu Arg Phe Asn Leu Leu Leu Leu Asp Val Gin Val Pro Glu Met 55 Asn Ser Leu Glu Leu Phe Lys Arg Ile Lys Asn Asp Phe Leu Ile Ser 70 75 Thr Pro Val Ile Phe Ile Thr Ala Leu Gln Asp Asn Ala Thr Leu Lys 90 Asn Ala Phe Asn Leu Gly Ala Ser Asp Tyr Leu Lys Lys Pro Phe Asp 100 105 110 Leu Asp Glu Leu Glu Ala Arg Ile Lys Arg Phe Phe Asn Asp Asp Pro 115 120 125 Ile Glu Ile Met Pro Asn Ile Phe Tyr His Gln His Ala Leu Asn Val 130 135 140 Lys Gly Lys Lys Glu Ile Leu Ala Pro Lys Thr Ala Gin Leu Leu Glu 145 150 155 160 Tyr Phe Leu Glu His Lys Gly Gln Ile Ile Ser Ser Gin Ala Leu Glu 165 170 175 Asn Asn Leu Trp Glu Gin Ala Ile Asp Asp Ser Thr Leu Arg Thr Tyr 180 185 190 Ile Lys Val Leu Arg Lys Leu Leu Gly Lys Asn Cys Ile Glu Thr His 195 200 205 Lys Gly Val Gly Tyr Arg Phe Asn Pro Leu 210 215 INFORMATION FOR SEQ ID NO:1582: SEQUENCE
CHARACTERISTICS:
LENGTH: 358 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION 1...358 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1582 Cys Gly Ala Asn Arg Ser Lys Gly Arg Gly Gly Phe Ser Ser Lys Cys 1 5 10 Ala Gly Ala Asn Ser Gly Tyr Ser Asn Glu Ala Tyr Glu Ser Val Gly 25 Ala Lys Ile Val Asp Ser Lys Thr Ala Trp Gly Gln Asp Leu Val Val 40 Lys Cys Lys Glu Pro Leu Glu His Glu Tyr Pro Leu Leu Lys Glu Lys 55 Ala Thr Leu Phe Ser Tyr Leou Asp Leu Ala Tyr Gln Lys Ser Leu Cys 70 75 Glu Met Phe Ile Asn Lys Lys Ile Thr Ser Ile Cys Thr Glu Thr Ile 90 Ala Gly Pro Lys Asn Asp Tyr Pro Ile Leu Ala Pro Met Ser Val Val 100 105 110 Ala Gly Arg Leu Ala Ala His Leu Val Gln His Tyr Leu Leu Ala Leu 115 120 125 Glu His Val Lys Gly Phe Met Gly Lys Gly Val Met Leu Gly Gly Leu 130 135 140 Ser Gly Ala Gln Arg Ala Lys Ile Val Val Ile Gly Gly Gly Val Val 145 150 155 160 Gly Met Glu Ser Ala Lys Val Leu Ser Gin Met Gly Ala Lys Val Thr PCT/US 96/091 2 IPEA 6Dj D EC1996 1134 165 170 175 Ile Leu Glu Leu Asp Tyr Ala Lys Leu Gln Asn His Pro Tyr Tyr His 180 185 190 Leu Tyr Asp Leu Glu Val Leu Ser Val Asn Glu Ala Asn Ile Ile Gin 195 200 205 Ala Leu Asn Gly Ala Val Gly Leu Val Gly Ala Val Leu Val Thr Ala 210 215 220 Ser Gin Thr Pro Lys Val Ile Leu Arg Arg His Leu Lys Tyr Met Gin 225 230 235 240 Thr Gin Gly Val Val Ile Asp Val Ala Cys Ser Leu Gly Gly Cys Ile 245 250 255 Arg Ala Ile Arg Gin Ala Ser His Ser Asn Pro Val Tyr Val Glu Glu 260 265 270 Ser Leu Leu His Tyr Gly Val Pro Asn Met Pro Gly Ile Val Ala Lys 275 280 285 Thr Ser Ser Thr Ala Tyr Ser His Ala Ser Val Pro Tyr Leu Leu Tyr 290 295 300 Tyr Leu Glu His Gly Leu Lys Gly Phe Leu Thr Ala Asn Thr Lys Ile 305 310 315 320 Val Ala Asn Thr Leu Gly Gly Leu Ser Ala Tyr Asn Gly Tyr Ile Thr 325 330 335 Gin Glu Gly Ile Ala Lys Ala Phe Asn Leu Ala Phe Lys Ser Pro Leu 340 345 350 Glu Ile Leu Lys Glu Leu 355 INFORMATION FOR SEQ ID NO:1583: SEQUENCE CHARACTERISTICS: LENGTH: 163 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION 1...163 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1583 Lys Gly Lyn Arg Val Lys Asn Met Arg Asp Phe Asn Asn Ile Gin Ile 1 5 10 Thr Arg Leu Lys Val Arg Gin Asn Ala Val Phe Glu Lys Leu Asp Leu 25 Glu Phe Lys Asp Gly Leu Ser Ala Ile Ser Gly Ala Ser Gly Val Gly 40 Lys Ser Val Leu Ile Ala Ser Leu Leu Gly Ala Phe Gly Leu Lys Glu 55 Ser Asn Ala Ser Asn Ile Glu Val Glu Leu Ile Ala Pro Phe Leu Asp 70 75 Thr Glu Glu Tyr Gly Ile Phe Arg Glu Asp Glu His Glu Pro Leu Val 90 Ile Ser Val Ile Lys Lys Glu Lys Thr Arg Tyr Phe Leu Asn Gln Thr 100 105 110 Ser Leu Ser Lys Asn Thr Leu Lys Ala Leu Leu Lys Gly Leu Ile Lys 115 120 125 Arg Leu Ser Asn Asp Arg Phe Ser Gin Asn Glu Leu Asn Asp Ile Leu 130 135 140 PCT 6 0912.
IPEAUS i DEC 1996 1135 Met Leu Ser Leu Leu Asp Gly Tyr Ile Gin Asn Lys Asn Arg Arg Leu 145 150 155 160 Ala Pro Phe INFORMATION FOR SEQ ID NO:1584: SEQUENCE CHARACTERISTICS: LENGTH: 297 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...297 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1584 Ser 1 His Lys Gin Leu Ser Ser Ala Lys Ile 145 Gin Lys Lys Ser Gly 225 Phe Phe Tyr Asn Ala Lys Leu Asp Val Tyr Asn Ala 130 Glu Asn Ile Lys Gly 210 Met Pro Asp His His Asn Ala Glu Lys Phe Leu Phe 115 Gin Leu Lys Ile Ala 195 Ser Phe Leu Lys Glu 275 Lys Ile Gln Asn Phe Ser Ile 100 Leu Asn Val Phe Ala 180 Leou Met Ser Ala Gly 260 Lys Arg Val Phe Met Asp f 5 Val Glu Ser Leu Glu Ala Val Leu Val His 165 Ser Glu Val Tyr Leu 245 Val Ser Ile lle Ser Glu 70 Glu Tyr Gly Val Ala 150 Phe Gly Gly Ala Pro 230 Met Lys Glu Glu Leu Gly 55 Glu Lys Asp Thr Ala 135 Leu Ile Gly Phe Asp 215 Gin Val Lys Cys Ile Glu 40 Asp Thr Glu Pro Ile 120 Ser Glu Glu Asn Phe 200 Val Lys Glu Arg Tyr 280 Ile 25 Lys Thr Phe Thr Leu 105 Ile Leu Glu Thr Gin 185 Ala His Lys Lys Leu 265 Leu Tyr 10 Ser Pro Pro Leu Pro 90 Asp Gly Tyr Val Ile 170 Lys Glu His Leou Ala 250 Leu Ala Lys Arg.
Leu Leu Asp Ala Ile Lys Ser Leu 75 Val Thr Gly Ser Val Tyr Val Val 140 Tyr Arg 155 Val Leu Asp Phe Asn Tyr Val Leu 220 Arg Lys 235 Lys Gly Asp Gin Ser Pro Phe Glu Gly Ala Glu Lys Ser Glu 125 Phe Tyr Glu Ser Arg 205 Val Leu Glu Sex His 285 Lys Lys Ser Asp Asn Glu Val 110 Lys Gly Ala Asn Leu 190 Leu Lys Phe Ala Val 270 Glu ;ly sly ryr Leu Val Asn Met Asp His Phe Lys 175 Gly Arg Lys Glu Phe 255 Glu Al Lys Val Thr Ala Lys Gly Glu Tyr Lys Tyr 160 Gly Leu Tyr Gly Val 240 Tyr Ser i Gin Ile Leu Glu Lys His Leu 290 Lys Gly Glu 295 PC 9 0 91 2. 2 !PENUS 18 DEC1996 1136 INFORMATION FOR SEQ ID NO:1585: SEQUENCE
CHARACTERISTICS:
LENGTH: 263 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...263 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1585 Thr Phe Leu Ile Ile Phe ft
L
lal Lys Leu Ile Phe Leu Ile Asn Ala Leu Leu Tyr Asn Pro Gly Lys 130 Phe Glu 145 Asn Val Gin Leu Ile Leu Phe Leu 210 Glu I Ile 1 Gly Ser Leu Gly Asn 115 Gin Pro Ile Ala Val 195 Phe Ala Lys Tyr Leu Ser Ala Gin Gly Phe 100 Tyr Glu Asn Asn Gly 180 Glu 5 Ser Met Gly Lys Tyr 85 Phe Asn Ile Met Asn 165 Asn Gin Met I Asn Tyr Gin 70 Gin Asp Ser Asn Leu 150 Gly Ser Ala rrp Lys Ala Leu 55 Ala Phe Tyr Glu Arg 135 Thr Ile Trp Lei Val Lys Val 40 Gin Thr Phe Ala Ala 120 Leu STyr Met Leu Val 200 Phe Phe 25 Ser Gly Asn Phe His 105 Ala Thr Gly Ser Met 185 Ser 10 Phe Gly Gin Ala Glu 90 Ala Gin Asn Gly Leu 170 Ala Lys Phe Leu Arg Ile Lys Ser Met Ala Thr 75 Lys Asn Val Ile Ala 155 Gly Thr Lys Gin Ser I 3 Asp Gly Gin Met 1 60 Ile Lys His Phe Ser Ile Ala Ser 125 Ala Asp 140 Met Asp Ala Phe Pro Ser Ala Thr 205 Leu Lys 220 Lys Asn "eu Asn Iis Sly Gly Lys 110 Gln Pro Val Gly Phe 190 Ser His Pro His Tyr Leu Ala Gly Val Ala Asp Phe Asp Leu Arg 95 Leu Lys Ile Leu Arg Thr Met Val 160 Gly Ile 175 Glu Gly Phe Gin Ser Ser Tyr Ile 240 r Trp Tyr 255
I
Asn Val Gly Ala Arg Leu Arg Ile 215 Ile 225 Thr Val Glu Ala Asn Gly Asn Val 260 Val Leu 245 Phe Lys 230 Asp Thr Phe Pro Met Leu Lys 23S Ile Gly Phe Arg 250 Phe Arg Val Tyr Se INFORMATION FOR SEQ ID NO:1586: SEQUENCE CHARACTERISTICS: LENGTH: 234 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein POT/US 9 6 /091 Z 2.
IPi U joCEGw1996 1137 (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...234 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1586 Trp Ile 1 Ile Ile Lys Lys Leu Glu Lys Ile Glu Lys Asp Ile Val Arg Asp Gly 130 Leu Leu 145 Asn Val Met Lys Pro Asn Asp Val 210 Asp Ala Lys Asn Lys Glu Asp Tyr Arg Pro Ile Ala Ala 115 Arg Asn Gly Val Leu 195 Val Pro Ala Leu Thr Pro Pro 100 Arg Leu Lys Glu Leu 180 Arg Val 5 Ser Thr Val Ile Glu Asp Phe Ile 40 Ala Lys Asp Tyr 55 Gly Ala Ile Arg 70 Ile Lys Asp Met 85 Leu Val Gln Asn Leu Ser Arg Val 120 Lys Phe Leu Thr 135 Leu Arg Glu Asn 150 Leu Gin Lys Leu 165 Gin Lys Gly Ile Lys Ala Leu Ser 200 Glu Ala Ile 10 Ala Thr His 25 Thr Lys Asp Pro Thr Ile Ser Val Leu 75 Leu Thr Ile 90 Asp Val Asn 105 Ile Thr Asn Phe Ser Thr Gly Thr Ser 155 Ile Glu Gly 170 Ala Pro Val 185 Asn Gin Met Ile Gin Gly Tyr Thr Ser Glu Leu 30 Glu Val Lys Ser 45 Val Glu Glu Ser Gin Ala Leu Leu Leu Glu Thr Ile Ile Leu Thr Glu 110 Ala Phe Lys Ser 125 Asp Ser Glu Gin 140 Lys Ser Leu Leu Val Ser Glu Glu 175 Ile Leu Ile Val 190 Glu Gln Ala Arg 205 Thr Val Leu Lys His Thr Gin Glu Phe Leu 160 Ala Glu Ile
L
Leu Ser His Ala Glu 215 Thr Ile His Ile Asn 230 Leu Phe Asp Pro Asn 220 Ser Asn Phe Glu 225 Ala Leu Gly INFORMATION FOR SEQ ID NO:1587: SEQUENCE CHARACTERISTICS: LENGTH: 295 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE.: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...295 (xi) SEQUENCE DESCRIPTION: SEQ ID N0:1587 Lys Lys Lys Thr Leu Asn Ile Ser Gln Leu Gly Lys Thr Met His Val A/i9 6 0912.2.
IPEA/US 1 DEC 1996 1138 1 Ala Lys His Glu Lys Ala Phe Lys Ile 145 Asn Asn Phe Asp Asn 225 Ile Arg Leu Phe Cys Glu Leu Ile Gin Iie Arg Glu 130 Tyr Pro Ile Cys Arg 210 Leu His Asp Lys Arg 290 Leu Ile Thr Ile Gly Lys Ser 115 Ile Gly Lys Ser Val 195 Val Ile Leu Asn Ala 275 His Leu Ala Leu Pro Val Lys 100 Phe Lys His Lys Leu 180 Thr Ala Leu Ala Asp 260 His Leu Ala Ser Lys Val Phe 85 His Leou Asn Val lie 165 Glu Leu His Glu Tyr 245 Asp Lys Gly Leu Lys Ile Phe 70 Trp Gin Leu Val Phe 150 Leu His Leu Tyr Ser 230 Tyr Phe Ser Gly Gin Ala 55 Glu Ala Ile Ser Tyr 135 Asp Ile Leu Asp Arg 215 Asp Leu Met His Asp Gin 40 Lys Asn Met Lys Gin 120 Gin Asn Asn Lys Phe 200 Ala Leu Lys Pro Phe 280 Asn 25 Gin Leu Ile Lys Arg 105 Phe Asn Pro Pro Ile 185 Glu Lys Tyr Lys Pro 265 Ile 10 Leu Ser Leu Pro Asp 90 Leu Val Arg Pro Phe 170 Val Glu Thr Ile Asn 250 Asn Glu Ile Leu Glu Ala 75 Phe Ile Ser Gin Tyr 155 Thr Leu Arg Ser Gly 235 Tyr Ser Gin Thr Leu Lys Ile Cys Glu Phe Tyr Leu Trp Leu Glu Ile Thr 125 Glu Leu 140 Pro Met Arg Glu Lys Leu Tyr Ala 205 Leu Glu 220 Gly Asp Phe Ile Gly Asn Asp Leu 285 Ser Leu Lys Asp Leu Lys 110 Thr Phe Ser Asn Leu 190 Phe Glu Ser Phe Glu 270 Ala Leu Gly His Leu Leu Gin Pro Ser Leu Asp 175 Lys Leu Val Phe Phe 255 Asn Lys Leu Thr Phe Lys Lys Asp Asn Gin Lys 160 Arg Pro Lys Lys Leu 240 Tyr Phe Lys Leu Leu 295 INFORMATION FOR SEQ ID NO:1588: SEQUENCE CHARACTERISTICS: LENGTH: 68 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM; Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...68 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1588 Asn Thr Gin Arg Gin Thr Leu Pro Leu Val Lys Ser Arg Pro His Pro 1 5 10 Leou Val Lys Ile Tyr Leu Lys Gin Met Cys Gly Met Gly Phe Ile Gly 25 Phe Lys Thr Lys Leu Thr Gin Thr Lys Ala Phe Ile Ile Leu Ile Pro 40 PCT/U3 9 6 0912.2 IPEA/US 1 DEC 1996 1139 Phe Gin Asp Arg Ala Val Lys Ala Ala Thr Arg Ser Ala Pro Ile 55 Leu Ile Cys Ile Gln INFORMATION FOR SEQ ID NO:1589: SEQUENCE
CHARACTERISTICS:
LENGTH: 1413 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...1413 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1589 Thr Leu Ile Ser Ile Phe Ser Ala Ser Gin Ala Asp Phe Gly Gly Asn 1 5 10 Thr Thr Ile Asp Thr Ala Ser Phe Asn Phe Asp Ser Ala Ser Ser Leu 20 25 Asn Phe Asn Asn Leu Thr Ala Asn Gly Ala Leu Asn Phe Asn Gly Tyr 40 Ala Pro Ser Leu Thr Lys Ala Leu Met Asn Val Ser Gly Gin Phe Val 55 Leu Gly Asn Asn Gly Asp Ile Asn Leu Ser Asp Ile Asn Ile Phe Asp 70 75 Asn Ile Thr Lys Ser Val Thr Tyr Asn Ile Leu Asn Ala Gin Lys Gly 90 Ile Thr Gly Ile Ser Gly Ala Asn Gly Tyr Glu Lys Ile Leu Phe Tyr 100 105 110 Gly Met Lys Ile Gin Asn Ala Thr Tyr Ser Asp Asn Asn Asn Ile Gin 115 120 125 Thr Trp Ser Phe Ile Asn Pro Leu Asn Ser Ser Gin Ile Ile Gin Glu 130 135 140 Ser I1e Lys Asn Gly Asp Leu Thr Ile Glu Val Leu Asn Asn Pro Asn 145 150 155 160 Ser Ala Ser Asn Thr Ile Ph. Asn Ile Ala Pro Glu Leu Tyr Asn Tyr 165 170 175 Gin Asp Ser Lys Gln Asn Pro Thr Gly Tyr Ser Tyr Asp Tyr Ser Asp 180 185 190 Asn Gin Ala Gly Thr Tyr Tyr Leu Thr Ser Asn lie Lys Gly Leu Phe 195 200 205 Thr Pro Lys Gly Ser Gin Thr Pro Gin Thr Pro Gly Thr Tyr Ser Pro 210 215 220 Phe Asn Gin Pro Leu Asn Ser Leu Asn Ile Tyr Asn Lys Gly Phe Ser 225 230 235 240 Ser Glu Asn Leu Lys Thr Leu Leu Gly Ile Leu Ser Gin Asn Ser Ala 245 250 255 Thr Leu Lys Glu Met Ile Glu Ser Asn Gin Leu Asp Asn Ile Thr Asn 260 265 270 Ile Asn Glu Val Leu Gin Leu Leu Asp Lys Ile Lys Ile Thr Gin Ala 275 280 285 Gin Lys Gin Ala Leu Leu Giu Thr Ile Asn His Leu Thr Asp Asn Ile 290 295 300 Asn Gin Thr Phe Ash Asn Gly Asn Leu Val Ile Gly Ala Thr Gin Asp
P.
P C7 96 16/09122 iPEA/US i6 DEC1996 1140 305 Asn Val Ser Ser Thr Tyr Ile Asn 370 Gly Ser 385 Gin Ser Ala Thr Ile Phe Giu Lys 450 Leu Ser 465 Lau Gly Ser Gly Ile Phe Lys Gin 530 Ile Gly 545 Ile Leu Gly Val Val Lys Val Il 611 Ser Va 625 Giy Th: Tyr Ph Phe Se Ile I 69 Ala Le 705 Leu As Ser Va Thr L) Ser L 310 ir Thr Ser Ser Ile Thr As Pro C) Lou G 355 Ala A Ser A Ala A Asp A 4 Asn G 435 Ile L Pro L Gin L Val M 5 Gly A 515 Ser L Gly T Lys A Val 2 Lys 595 Ser 0 1 Leu r Lou a Asn r Asn 675 e Ph.
0 u Ile n Ala l Gin s Asn ?u Ser in 10 sp sn sn sn 20 in eu eu :et 00 sn eu yr sp Ala Leu Prc Le Ph 661 Al As Ph Th Ly 74 Se Va
S
325 Ala Leu As Gin Leu LE Phe Lys A] 31i Ala Phe G 390 Asn Leu Vz 405 Ile Phe A Gly Asn L Gin Ala G 4' Ser Lys G 470 Ile Gly G 485 Asn Glu I Phe Val T Lys Ser M
S
Ile Asp A 550 Ile Thr A 565 Asn Asp L Giu Ser C Gly Gly I Pro Ser 630 i Ser Pro 645 e Lau Ser Thr Gly Gly Asp e Ala Ser 72.0 r Asn Gly.
725 s Gly Glu 0 r Ser Pro l His Ala p eu la T5 Lu sn eu ly 55 lu in le hr et 35 la sn eu .1n ;r Ser Gly 360 Lys Ser Leu Leu Ala 440 Gly Leu Asn Gin Pro 520 Lou Ser Pro Lou Gly 600 Ser g Gly Ala Th 345 Ser Th Ser Il Gly G Asn Li 43 Lou GI 425 Asn Va Lou G Pro A Asn L 44 Asn I 505 Ser I Asp A Glu L Pro T 5 Asn G 585 Lou V Gly V Asn Leau y Tyr r Lou 0 r Ile y Val r Lou z Ile 745 n Ser 0 n Phe Trp P r C r S e0 I al
S
.0 ly la eu le le sp eu hr 70 lu al la 'is 650 lal :Ys er Tyr er 195 la Gin Leu Asn Ser 475 Asp Ile Ile Lys Ser 555 Ser Phe Ser Tyr Le 63! As Ph Ser Pro Ile 380 Ala Asn Giu C Ser Phe 460 Lou Asp Ser Glu Gly 540 Ser Lou Lou Asn Asn 620 aLys p Phe e Val he Gly Gly Asn G er yr 165 Thr Asp le ly G1n 145 Ile Gin Lou Gin Asn 525 Leu Ile Gin Gly Ile 60S Glr Gi Tr As Phe A 350 Leu G Gly T Val T GCu P 4 Ile A 430 Met P Giu Asp C Lou 1 Lys 510 Tyr Lou Lou Lys Gin 590 Ile Gly u Asn p Gin n Asn 670 ly 35 rg ly rhr hr la i5 sp la Asn ;iu Asn 195 Leu Leu Asn Gly Asp 575S As; Asr Le As Ly 65 Se Tyr Asn Tyr Ile Phe 400 Gin Lys Met Ala Thr 480 Asn Ser Ala.
Phei Val 560 Ile Val Asn I Gly p Leu 640 s Gly 5 r Sen Asn Gly Asn 695 Msn Lou Ile Ala Asn 775 Gl Se 68 Th G1 So Cy As 76 As Asn Asp Ser Asn 730 Asn Ser Thr Phe Val Ala Asn Lys Ser 685 Phe Ser Lys Tyr Gin Gly 700 Asn Ile Asn Ile Thr Thr 715 720 Ala Gly Lou Asn Asn Val 735 Lou Ala Asn Cys Pro Thr 750 Val Thr Pro Thr Asn Giu 765 Phe Lou Cly Thr Ile Ile 780 Thr Asn Asn Ser Val Ile 795 800 Lou Gin Ala Asn Asn Lou 815 Asn Ser Thr Ala Asn Ile 770 Ser Asn 785 Gly Thr Thr Ile Gly Lou Thr Ala Asn Asn 820 Ile Asp Lou 790 Leu Asn Giu 805 Ala Phe Asn Ser Gin Val Asn Ala Thr sic Asn Ala Se 825 830 rA*.
PCT/US 9 6/0912. 2 114 !PEAUS JDEC1996 1141 Asp Gly Asn Phe Thr Leu Asn Gin Gin Ala Thr Leu Ser Thr Asn Ala 835 840 845 Ser Gly Leu Asn Val Met Gly Asn Phe Asn Ser Tyr Gly Asp Leu Val 850 855 860 Phe Asn Leu Ser His Ser Val Ser His Ala Ile Ile Asn Thr Gin Gly 865 870 875 880 Thr Ala Thr Ile Met Ala Asn Asn Asn Pro Leu Ile Gin Phe Asn Ala 885 890 895 Ser Ser Pro Glu Val Gly Thr Tyr Thr Leu Ile Asp Ser Ala Lys Ala 900 905 910 Ile Tyr Tyr Gly Tyr Asn Asn Gln Ile Thr Gly Gly Ser Ser Leu Asp 915 920 925 Asn Tyr Leu Lys Leu Tyr Ala Leu Ile Asp Ile Asn Gly Lys His Met 930 935 940 Val Met Thr Asp Asn Gly Leu Thr Tyr Asn Gly Gin Ala Val Ser Val 945 950 955 960 Lys Asp Gly Gly Leu Val Val Gly Phe Lys Asp Ser Gin Asn Gin Tyr 965 970 975 Ile Tyr Thr Ser Ile Leu Tyr Asn Lys Val Lys Ile Ala Val Ser Asn 980 985 990 Asp Pro Ile Asn Asn Pro Gin Ala Pro Thr Leu Lys Gin Tyr Ile Ala 995 1000 1005 Gin Ile Gin Gly Val Gin Ser Val Asp Ser Ile Asp Gln Ala Gly Gly 1010 1015 1020 Asn Gln Ala Ile Asn Trp Leu Asn Lys Ile Phe Glu Thr Lys Gly Ser 1025 1030 1035 1040 Pro Leu Phe Ala Pro Tyr Tyr Leu Glu Ser His Ser Thr Lys Asp Leu 1045 1050 1055 Thr Thr Ile Ala Gly Asp Ile Ala Asn Thr Leu Glu Val Ile Ala Asn 1060 1065 1070 Pro Asn Phe Lys Asn Asp Ala Thr Asn Ile Leu Gln Ile Asn Thr Tyr 1075 1080 1085 Thr Gin Gin Met Ser Arg Leu Ala Lys Leu Ser Asp Thr Ser Thr Phe 1090 1095 1100 Ala Arg Ser Asp Phe Leu Glu Arg Leu Glu Ala Leu Lys Asn Lys Arg 1105 1110 1115 1120 Phe Ala Asp Ala Ile Pro Asn Ala Met Asp Val Ile Leu Lys Tyr Ser 1125 1130 1135 Gin Arg Asn Arg Val Lys Asn Asn Val Trp Ala Thr Gly Val Gly Gly 1140 1145 1150 Ala Ser Phe Ile Ser Gly Gly Thr Gly Thr Lou Tyr Gly Ile Asn Val 1155 1160 1165 Gly Tyr Asp Arg Phe Ile Lys Gly Val Ile Val Gly Gly Tyr Ala Ala 1170 1175 1180 Tyr Gly Tyr Ser Gly Phe His Ala Asn Ile Thr Gin Ser Gly Ser Ser 1185 1190 1195 1200 Asa Val Asa Val Gly Val Tyr Ser Arg Ala Phe Ile Lys Arg Ser Glu 1205 1210 1215 Leu Thr Met Ser Lou Asn Glu Thr Trp Gly Tyr Asn Lys Thr Phe Ile 1220 1225 1230 Asn Ser Tyr Asp Pro Leu Leu Ser Ile Ile Asn Gin Ser Tyr Arg Tyr 1235 1240 1245 Asp Thr Trp Thr Thr Asp Ala Lys Ile Asn Tyr Gly Tyr Asp Phe Met 1250 1255 1260 Phe Lys Asp Lys Ser Val Ile Phe Lys Pro Gin Val Gly Leu Ser Tyr 1265 1270 1275 1280 Tyr Tyr Ile Gly Leu Ser Gly Leu Arg Gly Ile Met Asp Asp Pro Ile 1285 1290 1295 Tyr Asn Gln Phe Arg Ala Asn Ala Asp Pro Asn Lys Lys Ser Val Leu 1300 1305 1310 Thr Ile Asn Phe Ala Leu Glu Ser Arg His Tyr Phe Asn Lys Asn Ser 1315 1320 1325 Tyr Tyr Phe Val Ile Ala Asp Val Gly Arg Asp Leu Phe Ile Asn Ser 1330 1335 1340 Met Gly Asp Lys Met Val Arg Phe Ile Gly Asn Asn Thr Leu Ser .Tyr PCT/US 9 6 /0912 .2 IPEAlUS 18 DEC 1996 1142 1345 Arg Glu Arg Met Asp Ile Phe Arg 1410 1350 1355 1360 Gly Gly Arg Tyr Asn Thr Phe Ala Ser Ile Ile Thr Gly Gly 1365 1370 1375 Arg Leu Phe Lys Thr Phe Tyr Val Asn Ala Gly Ile Gly Ala 1380 1385 1390 Gly Leu Asp Tyr Lys Asp Ile Asn Ile Thr Gly Asn Ile Gly 1395 1400 1405 Tyr Ala Phe INFORMATION FOR SEQ ID NO:1590: SEQUENCE CHARACTERISTICS: LENGTH: 193 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...193 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1590 Arg Asp 1 Asn Leu Phe Asp Leu Ala Asn Cys Met Gin Arg Gin Ser Pro Lys Ala 130 Trp Gin 145 Tyr Ile Val Glu Leu Asn Met Glu Leu Ile Leu Gly Ser Gln Ser Ser Leu Glu Cys Ala Arg Asn Val 115 Phe Gly Lys Gly Lys Glu Lys Ile Lys Gly 100 Leu Asp Ser Ser Leu 180 5 Glu Ser Gly Val Ala Asn Glu Cys Ala Ser 165 Leu His Gly Ile Leu Lys Thr 40 Lys Leu Glu 55 Val Ala Asp 70 Lys Asn Lys Glu Ile Glu Trp Leu Asp 120 Ser Glu Ile 135 Gly Cys Val 150 Ser Lys Asn Gly Ala Leu Lys 25 Thr Lys Ser Arg Val 105 Leu Glu Arg Leou 10 Phe Asp Ala Val Glu 90 Leou Ser Lys Leu Ser 170 Glu Pro Lys Val 75 Ala Thr Val Tyr Glu 155 Val Gin Arg Glu Ser Leu Cys Phe Leu 140 Asp Gly Lys Glu Leou Val Glu Ser Arg 125 Glu Phe Leu Ala Arg Ala Ala Leu Tyr Phe Val Tyr Leu Ala Asn Gly Asn Arg Phe Leu Lys Ala Leu Ile 110 Ala Arg Leu Ser Gly Leu His Lys Pro 160 Gly Leu Asn 175 Lys Leu Gly Val Lys Leu Ser Leu 185 190 INFORMATION FOR SEQ ID NO:1591: SEQUENCE CHARACTERISTICS: LENGTH: 168 amino acids TYPE: amino acid TOPOLOGY: linear ACT/US 96/09122 i-b S DEC 1996.
1143 (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...168 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1591 Arg Met Ala Leu Phe Gly Ser Lys Ser Lys Met Leu Glu Thr Tyr Ala 1 5 10 Leu Lys Ser Gly Ala Val Phe Ile Ser Asp Ala His Phe Leu Pro Lys 25 Ser Pro His Leu Ile His Thr Leu Lys Glu Leu Leu Ser Ala Lys Pro 40 Pro Gin Val Phe Phe Met Gly Asp Ile Phe His Val Leu Val Gly Tyr 50 55 Leu Pro Leu Asp Lys Glu Gin Gin Lys Ile Ile Asp Leu Ile His Ala 70 75 Leu Ser Glu Ile Ser Gln Val Phe Tyr Phe Glu Gly Asn His Asp Phe 90 Ser Met Arg Phe Val Phe Asn Ser Lys Val Met Val Phe Glu Arg Gin 100 105 110 Asn Gin Pro Ala Leu Phe Gin Tyr Asp Asn Lys Arg Phe Leu Leu Ala 115 120 125 His Gly Asp Leu Phe Ile Thr Lys Ala Tyr Glu Phe Tyr Ile Thr Gin 130 135 140 Leu Thr Ser Thr Trp Ala Arg Phe Phe Leu Thr Phe Leu Asn Leu Leu 145 150 155 160 Ser Phe Lys Thr Leu Tyr Pro Phe 165 INFORMATION FOR SEQ ID NO:1592: SEQUENCE
CHARACTERISTICS:
LENGTH: 320 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION 1...320 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1592 Asn Asp Asp Glu Asn Lys Val Ile Glu Leu Lys Thr Arg Asn Asn Met 1 5 10 is Arg Ile Val Phe Met Gly Thr Pro Ser Phe Ala Glu Val Ile Leu Arg 25 Ala Leu Val Glu Asn Glu Asp Lys Lys Ile Glu Val Val Gly Leu Phe 40 Thr Gin Arg Asp Lys Pro Phe Gly Arg Lys Lys Glu Leu Lys Ala Pro A!i' PCT/US 96/0912.2.
PEAUS DE1996 1144 55 Glu Thr Lys Thr Tyr Ile Leu Glu Asn His Leu Asn Ile Pro Ile Phe 70 75 Gin Pro Gin Ser Leu Lys Glu Pro Glu Val Gin Ile Leu Lys Gly Leu 90 Lys Pro Asp Phe Ile Val Val Val Ala Tyr Gly Lys Ile Leu Pro Lys 100 105 110 Glu Val Leu Thr Ile Ala Pro Cys Ile Asn Leu His Ala Ser Leu Leu 115 120 125 Pro Lys Tyr Arg Gly Ala Ser Pro Ile His Glu Met Ile Leu Asn Asp 130 135 140 Asp Arg Ile Tyr Gly Ile Ser Thr Met Leu Met Asp Leu Glu Leu Asp 145 150 155 160 Ser Gly Asp lie Leu Glu Ser Ala Ser Phe Leu Arg Glu Asp Tyr Leu 165 170 175 Asp Leu Asp Ala Leu Ser Leu Lys Leu Ala Arg Met Gly Ala Thr Leu 180 185 190 Leu Leu Ser Thr Leu Lys Asn Phe His Ser Ile Thr Arg Lys Pro Gin 195 200 205 Asp His Met Gin Ala Ser Phe Cys Lys Lys Ile Ala Lys Ala Asp Gly 210 215 220 Leu Val Gly Phe Lys Asp Ala Lys Asn Leu Phe Leu Lys Ser Leu Ala 225 230 235 240 Phe Lys Ser Trp Pro Glu Ile Phe Leu Glu Asn Ser Leu Lys Leu Leu 245 250 255 Glu Val Glu Leu Val Glu Asn Glu Lys Ser His Lys Glu Gly Glu Ile 260 265 1 270 Leu Ala Ile Asp Glu Arg Gly Val Leu Val Gly Cys Leu Lys Gly Se 275 280 285 Val Arg Ile Ala Arg Leu Gin Ala Val Gly Lys Lys Pro Leu Lys Ala 290 295 300 Lys Asp Tyr Leu Asn Gly Arg Arg Leu Lys Val Gly Gly Ile Leu Thr 305 310 315 320 INFORMATION FOR SEQ ID NO:1593: SEQUENCE
CHARACTERISTICS:
LENGTH: 171 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc.feature LOCATION.1 171 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:159 3 Lys Ser Thr Arg Lys Thr Ile Met Glu Ala Gin Leu Arg Phe Thr Gly 1 5 10 Val Gly Gly Gin Gly Val Leu Leu Ala Gly Glu lie Leu Ala Glu Ala 25 Lys Ile Val Ser Gly Gly Tyr Gly Thr Lys Thr Ser Thr Tyr Thr Ser 40 Gin Val Arg Gly Gly Pro Thr Lys Val Asp Ile Leu Leu Asp Lys Asp 55 Glu Ile Ile Phe Pro Tyr Ala Lys Glu Gly Glu Ile Asp Phe Met Leu 70 75 PCT/US 091 2.
IPEA/US i DEC 1996 Ser Gly Asp Lys Ile 145 Thr Val Gly Glu Asp 130 Thr Met Ile Val Tyr Gly Leu Lys 165 1145 rs Ser Li Thr -o Ile r Val 140 .u Asn Lys Glu Ala Ala Asp 160 INFORMATION FOR SEQ ID NO:1594: SEQUENCE CHARACTERISTICS: LENGTH: 428 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...428 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1594 Ala 1 Gly Ala Pro Leu Lys Ala Ile Ile Ala 145 Glu Lys Asn Arg Asp 225 Cys Asp Thr Lys Gly Phe Val Asp Phe 130 Pro Ser Lys Phe Lys 210 Thr Leu Lys Gin Glu Asn Asn Leu Tyr Ser Asp Ala Thr 115 Asn Arg Leu Gin Glu 195 Tyr Ile Ser Phe Lys Leu Tyr Tyr 100 Leu Ile Ile Glu Ile 180 His Leu Thr 5 Trp Arg Thr Cys Trp Cys Val Leu Leu Ile 165 Thr Cys Phe Leu Ala Lys Phe Val 70 Phe Gin Phe Tyr Lys 150 Leu Thr Arg Ser Gly 230 Asp Ser Asn 55 Phe Leu Phe Val Pro 135 Lys Arg Asn His Ser 215 Tyr Ile Asp Val 40 Pro Tyr Leu Ile Ala 120 Asn Ala Ile Gin Leu 200 Asn Ser Thr Asn Ala 25 Leu Thr Lys Gly Tyr 105 Arg Ser Val Leu Gin 185 Ala Leu Ser 10 Met Lys Ser Asn Ala 90 Lys Asp Tyr Phe Glu 170 Ala Leu Glu Gin Thr Gin Pro Lys Gin Leu Val Ala Tyr Ile 75 Met Gin Glu Ile Gly Tyr Lys Thr 140 Leu Glu 155 Gly Glu Tyr Val Lys Cys Gly Asn 220 Gly Leu 235 Ile Ser Glu Gin Gin Ala His Leu 125 Thr Val Glu Tyr Leu 205 Ile Ile Leu Leu Glu Ser Lys Gly Lys 110 Leu Tyr Val Glu Leu 190 Asp Ala Gin His Gly Val Phe His Ile Arg Gin Val Glu Val 175 Tyr Asn Ile Lys Ile Ile Phe Ile Glu Ala Asn Lys Tyr Gly 160 Lys Ser Tyr Val Ala 240 Leu Asn Lys Glu Val Phe Gly Cys Tyr Val Asp Leu Leu Arg Ile Leu POUS 9 6 0 912 IPL~~U~ J C 19 9S 1146 Asn Tyr Val 305 Giu Leu Pro Asp Leu 385 Arg Lou Ph.
Pro 290 Ser Gly Asp Ser Ala 370 Leu Ser Ile.
Asp His 275 Ile Ser Ala Ile Ile 355 Thr Ser Leu Lys Cys 260 Asn Leu Cys Val His 340 Gin His Cys Arg Lys 420 245 Val1 Trp Asn Giu Gly 325 Asp Asp Lys Ile Thr 405 Ile Leu Met 280 Asn Arg Ser Giu Gin 360 Leu Pro Gin Lys Pro 265 Glu Gly Ser Tyr Trp 345 Phe Pro Ser Giu Leu 425 250 Phe Phe Val1 Lys Phe 330 Val Arg Leu Gin Arg 410 Lys Ser Leu Pro Ala 315 Lys Asn Gin Phe Ser 395 Leu Lys His Leu Ile 300 Tyr Glu Phe Ile Cys 380 Tyr Ph.
Lys INFORMATION FOR SEQ ID NO:i595: SEQUENCE CHARACTERISTICS: LENGTH: 375 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .375 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1595 1Gly Leu Lou Ala Asn Trp Ile Val Asp Asp Ph.
Ser Ser 145 Lou Giy Tyr Met Met Ala Thr Gly 130 Leu Met Val Val Tyr Gly Leu Ser Gin Met Trp Asn Ser Ile Ser Ile 100 G ly Pro Phe Cys Pro Met Leu Phe Val Gin Val Ile Val1 Lou Phe Trp Asn 70 Trp Trp Ile Phe Tyr 150 Asp Gly Tyr 55 Asn His Trp Gly Sen 135 Ile Ile Sen 40 Tyr Leu Sen Trp Thr 120 Tyr Trp Ile 25 Met Ile Sen Ile Giy 10s Ile Lys Ala Val Sen Ala Ile Sen 90b His Tyr Leu C ly Val Val Thr Pro 75 Met Asn Tyr Thr Gly 155 Val Ang Tyr Thr Tyr Ala Phe Leu 140 His Leu Leu Val Leu Leu Asn Leu Lys Ile Ala Arg Val Tyr Sen Val Leu 125 Phe His Trp Glu Gly Ph.
Gly Ala 110 Pro Sen Leu Thr Val Asn Ile Val Ser Phe Lys Ph.
Ile Pro Lou Thr Ala Ala Asn Val Glu Trp Tyr 160 AM05.9 SNET' 1147 Ser Thr Val Leu Met Arg Leu Val 210 Ile Gin 225 Ile Ile Leu Ilie Ile Tyr Gly Ile 290 Gly Met 305 Phe Ile Val Gly Ile Phe Tyr Ala 370 Val Ile Gly 195 Leu Ala Giy Ala Ser 275 Val1 Met Asp Gly Met 355 Thr Pro Leu 180 Gin Ala Ile His Ser 260 Gly Leu Trp Thr Leu 340 Thr Pro Asp Trp Val Gin 165 Pro Ser Trp Giy Trp His Gin Leu 200 Ser Thr Phe Tyr 215 Lys Ser Val Asn 230 Val His Asp Gly 245 Met Tyr His Met Arg Leu Vai Asp 280 Tyr Phe Ser Ser 295 Arg Asp Val Asp 310 Val Lys Ala Leu 325 Met Tyr Phe Ile Ile Thr Ala Giy 360 Met Ala Arg 375 Leu 170 Ala Giu Leu Leu Leu 250 Pro Gin Trp Tyr Pro 330 Phe Lys Ser Ile Ser Ser Ala 235 Gly Arg Phe Ile Gly 315 Tyr Ile Leu Ser Asn Pro Thr 220 His Trp Leu Trp Ala 300 Asn Tyr Ile Glu Val1 Met Leu 205 Leu Phe Val Phe Ile 285 Gly Leu Asn Phe Arg 365 Phe Leu 190 Ile Giu Thr Gly Lys 270 Met Ile Thr Ile Ala 350 Glu Ser 175 Leu Lys Gly Asp Phe 255 Arg Thr Thr Tyr Arg 335 Tyr Pro Val1 Thr Phe Ser Trp 240 Thr Glu Leu Gin Gin 320 Gly Asn Asn INFORMATION FOR SEQ ID NO:1596: Ci) SEQUENCE CHARACTERISTICS: LENGTH: 301 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .301 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1596 Plie Asp Asp Asp Met Glu Ile Arg Asn Ile Lys 5 10 Ser Lys Lys Leu Gin Lys Asp Thr Leu Lys Ile 25 *Ph. Leu Ile Gly Ala Ala Leu Leu Ala Leu Ile 40 Ser Lys Gly Leu Leu Leu Ile Phe Ala Ala Val 55 *Aia Met Asn Ile Gly Ala Asn Asp Val Sen Asn 70 *Val Gly Sen Lys Ala Ile Ser Met Giy Gly Ala 90 *Val Cys Glu Met Leu Gly Ala Ile Ile Ala Giy 100 105 Thr Ile Lys Gly Arg Ilie Val Sen Pro Giu Phe Gly 1 Ala Leu Asn Met Ser Ala Ser Giu Phe Glu Aia Leu Ala Ph. Gly Gin Ile Gly Gly Asn Val Gly Ile Leu Ile Gly Giu Val 110 Ile Asn Asp PCIUS 96/0912.2 IPE.'10-PQ 1lb KC 1996 1148 His Val 130 Trp Leu 145 Ser Val Ser Ala Ile Ser Ile Lys 210 Lys Val 225 Tyr Leti Ilie Gin Phe Lys Giu Ser 290 115 Phe His Val1 Ile Pro 195 Lys Vai Ile Leu Arg 275 Val1 Vai Thr 150 Ile His Gly Ala Leu 230 Val Gly Leu Leu Ala Gly Aia Ser 185 Ile Glu Leu Arg Leu 265 Ala Val1 Giy Thr Ala Ser 190 Leu Ala Phe Gly Phe 270 Asn Ala Ser Gly 175 Trp Met Ala Ser Phe 255 11ir Ser INFORMATION FOR SEQ ID NO:1597: SEQUENCE CHARACTERISTICS: LENGTH: 432 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM. Helicobacter pyiori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .432 (xi) SEQUENCE DESCRIPTION: SEQ ID N0:1597 1Arg Met Lys Leu Lys Lys Thr Leu Thr Ph. Leu Leu Ph.
Glu Lys Asp Ph.
Thr Thr Thr Ala Lys Glu Leu Giu 130 Ser Ser 145 ser Val Asn Lys Ala Leu Lys 115 Glu His
S
Asp Asn Lys Thr Leu Ala Ile Lys Ser Leu Leu Gly 100 Gly Leu Ala Ile Ala Ile Thr Pro Ile Ile 70 Met Thr Thr Arg Val 150 Asn Giu Leu Asn 40 Leu Asp 55 Val Gly Tyr Ser Arg Gly Thr Pro 120 Leu Lys 135 Gin Lys Val 25 Giu Ph.
Ile Leu Phe 105 Thr Cys Arg Tyr Leu Lys Asn Thr Leu 90 Ph.
Leu Giu Ile Giu Tyr Glu Gly 75 Leu Ile Leu Tyr Ala 155 Asn Ala Leu Thr Asp Asp Giu Phe 140 Gly Pro Pro Lys Asn Leu Asp Leu 125 Ile Leu
LYS
Leu Asn Gly Asn Lys 110 Tyr Met Asp Gin His His Ala Tyr Ser Glu Ile Ile Ala Tyr Phe Lys Thr Lys Lys His Ile Ser Asp Giu Val Phe Ala 160 POUS 92/ 2 IU~~u: 6 g6 19 1149 Lou LYS lie Lou Thr 165 Asn Ile Giu Asn Tyr 180 Giy Leu LYS Val Ile 195 Ile Asn Ala Arg Thr 210 Gin Ala Phe Sor Leu 225 His Asp Lou Arg Asp 245 Pro Lou Lou Gly Arg 260 Gly Val Lys Lou Lou 275 Lou Giu Asn Phe Tyr 290 Lys Pro Lou Vai Val 305 Gin Vai Pho Glu Sor 325 Ala Gly Gly Asp Arg 340 Ala Ser Cys Tyr Ala 355 Ser Giu Asn Glu Giu 370 Asn Sor Sor Lys Val 385 Asn Ala Lou Glu Asn 405 Lys.Gly Asp Giu Asn Asn Arg Asn Tyr Asn 230 Pro Tyr Thr Gly Val1 310 Phe Asp His Asp Ile 390 Lou Ile Ile Asp Arg Aia 215 Pro Asn Asn Gin Val 295 Asp Lys Lys Gin Ile 375 Val1 Lys Gin Thr Ala Asp 200 Lou Ser Lou Lou Lou 280 Lys Phe Asn Thr Ile 360 Ile Glu Asp Ile Ser Lys 185 Glu Asp Ile Lys Tyr 265 Pro Gly Ala Gin Lys 345 Ile Lys Lys Asp Phe 425 His Ser Asn Lys Ala 235 Thr Ile Giu Lou Thr 315 Ile Pro Thr Ile Arg 395 Val1 Asp Asp Phe Lou 205 His Lou Lou Ala Ile 285 Ile Asp Ala Met Asp 365 Lys Lys Lou Thr Phe Lys 190 Phe Lou Cys Ile Giy 270 Ala Val Gly Lou Gly 350 Asn Gly Ala Ile Ile 430 His 175 Asp Asn Asn Tyr His 255 Val Pro His Met Ph.
335 Ala Pro Ile Ile Lou 415 Ph.
Gin Giu Pro Val Gin 240 Sor Lou Lou Sor Gin 320 Giy Ile Arg Asn Lou 400 Gly Ph.
INFORMATION FOR SEQ ID NO:1598: SEQUENCE CHARACTERISTICS: LENGTH: 327 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY; misc-feature LOCATION .327 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1598 Arg Lou Lou Ser Gin Ph. Lys Thr Arg Ile Asn Met Gin Glu Phe Ser 1 5 10 Lou Trp Cys Asp Ph. Ile Glu Arg Asp Ph. Leu Glu Asn Asp Phe Leu 25 Lys Lou Ile Asn Lys Gly Ala Ile Cys Gly Ala Thr Sen Asn Pro Ser 40 Lou Ph. Cys Giu Ala Ile Thr Lys Sen Ala Ph. Tyr Gin Asp Giu Ile 55 Ala Lys Lou Lys Gly Lys Lys Ala Lys Glu Ile Tyr Glu Thr Lou Ala PCT/US 9 6 0912. 2.
IPEA/US i DEC 1996 1150 Leu Lys Glu Thr Ala 145 Val Leu Arg Gin His 225 Ser Asn Asp Ala Ala 305 Glu Lys Asp Asp Leu 130 Phe Thr Ala Phe Ser 210 Ala Asn Ser Pro Phe 290 Gin Lys Asp Pro Asp 115 Asn Glu Leu Lys Asp 195 Gly Asn Ser Ile Asn 275 Lys Lys Leu lle Asn 100 Ala Arg Val Val Glu 180 Lys Ile Lys Leu Asn 260 Thr Lys Leu Leu Leu Asn Ile Pro Ile Phe 165 Ala Glu Met Leu Ala 245 Thr Glu Glu Leu Ser 325 70 Gin Gly Lys Asn Ser 150 Ser Arg Ile Asn Ile 230 Lys Ala Cys Leu Lys 310 Ser Ala Tyr Ser Val 135 Ala Pro Lys Asp Ala 215 Ser Asp Pro Gin Lys 295 Glu Phe Ser Ser Ala Ile lie 120 Met Leu Lys Arg Pro 200 Thr Thr Tyr Leu Thr 280 Thr Gly Ser 105 Asp Ile Ala Ile Ala 185 Leu Glu Leu Tyr Asp 265 Pro His Leu 75 Leu Met Pro Glu Ile Asp Ala Lys Arg 125 Val Pro Ala 140 Ala Ser Ile 155 Gly Glu Ile Ile Ser Val Pro Gln Asn 205 Tyr Tyr Gin 220 Ala Ser Thr 235 Lys Ala Leu Leu Asn Ala Lys Ile Thr 285 Ile Asp.Leu 300 Ala Phe Lys Leu Pro 110 Leu Ser Pro Ala Phe 190 Leu Ile Gly Cys Tyr 270 Glu Glu Gin Tyr Phe Phe Glu Ile Gin 175 Val Gin Asn Val Phe 255 Leu lie Asn Ser 8
C
I
S
I
A
1
I
S
C
1
I
I
I
;1u eu Lys er sn le er la 1in Lys 240 .ys Leu lu rhr Phe 320 Lys Ile Ile Leu Ile INFORMATION FOR SEQ ID NO:1599: SEQUENCE CHARACTERISTICS: LENGTH: 358 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION.1...358 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1599 Gly Phe Lys Val Arg Leu Phe Arg Phe Val Gly Trp Tyr Tyr Phe 1 5 10 Tyr Phe Leu Ile Val Leu Leu Ala Leu GIu Leu Phe Phe Val Gly 25 Asp Ser Leu Lys Tyr Ala Asp Lys Met Pro Asp Ser Ala Asn Met 40 lie Leu Phe Phe Thr Tyr Asp Ile Leu Phe Ala Leu Asn Tyr Thr 55 Pro Ile Ser Leu Leu Leu Ala Met Val Leu Phe Tyr Ile Thr Phe 70 75 PGT/US 9 6 /0912 Z IPEA/US io.EC1996 1151 Lys Ser Asn Gin Tyr Thr Ala Leu Leu Gin Tyr Gin Leu 145 Leu Thr Tyr Glu Thr 225 Lys Val Phe Tyr Leu 305 Leu Leu Lys Ile Leu Val Gly 115 Asn Leu 130 Val Lys Leu Gin Leu Glu Trp lie 195 Leu Gly 210 Leu Lys Pro Ala Arg Gin Ala lie 275 Phe Ser 290 Lys Phe Gly Lys Ser Pro Leu Asn 355 Ser Pro 100 Leu Asn Ile Tyr Tyr Asn Lys Ala 165 Ser Tyr 180 Leu His Ala Asn Asn Phe Val Ser 245 Asn Ala 260 Leu Pro Pro Ser Ile Ile Phe Ser 325 Phe Phe 340 Lys Arg Ile Ala Lys Asp 150 Gin Ala Asp Ala Arg 230 Ile Asp Phe Leu Ile 310 Ile Val Leu Phe Thr Asp 135 Asp Asn Glu Thr Leu 215 Pro Thr Thr Phe Ala 295 Thr Ser Phe Leu Pro 120 Asn Tyr Ile Ala Thr 200 Asn Lys Asp Lys Val 280 Arg Leu Gly Leu Ile 105 Phe Ser Val Lys Lys 185 Ile Thr Val Ala Lys 265 Pro Tyr Val Ile Ala 345 Ser Ile 90 Ser Leu Val Tyr Leu Ser Tyr Phe 155 Val Phe 170 Glu Ala Tyr Glu Thr His Leu Asp 235 Leu Leu 250 Val Arg Phe Leu Glu Asn Val Trp 315 Leu Ile 330 Leu Ser Gly Phe Met Val 140 Asp Arg Phe Met Leu 220 Thr Ser Ser Ser Leu 300' Gly Pro Leu Phe Phe Glu 125 Ser Lys Leu Phe Pro 205 Glu Ile Leu Phe Val 285 Ala Leu Glu Trp Ser Thr 110 Glu Glu Ile Lys Glu 190 Leu Thr Tyr His Leu 270 Leu Leu Phe Ile Tyr 350 Lys Ala Lys His Asn Asp 175 Asp Ser Phe Gin Ala 255 Tyr Ile Leu Phe Gly 335 Phe Cys Val Thr Leu Pro 160 Lys Lys Phe Lys Asn 240 Leu Val Ala Gly Ala 320 Val Lys INFORMATION FOR SEQ ID NO:1600: SEQUENCE CHARACTERISTICS: LENGTH: 459 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...459 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1600 Lys Arg Arg Val Val Lys Phe Tyr Thr Tyr Ser Gly Glu Thr Ala Ala 1 5 10 Glu Ala Leu Lys Ile Ala Gin Ser His His Gly Val Asp Thr Leu Val 25 Phe Lys Thr Gin Glu Ile Arg Lys Lys Thr Leu Thr Ser Ser Gly Leu 40 Tyr Glu Ile Val Val Ala Val Glu Glu Glu Glu Asn Lys Lys Ala Pro PCT!US 96/091?2 ,,US 18DEC1996 1152 Leu Val Val Leu Gin Giu 145 Asn Met Phe His Met 225 Arg Arg Leu Lys Gin 305 Ile Asp Lys Val Ii 38! Ly Gl Me As Ile P Met G Ser S Glu Asp 130 Arg Ala Phe Ala Leu 210 Arg Lys Ile Ala Val 290 Leu Asp Phe Ile Ser 370 D Tyr s Leu u Ser t Asp p Gly 450 ro In er Lys 115 Ala Glu ;Gn rrp Giu 195 Asp Glu Ile Leu Lys 275 Gly Ser Ala Ile Ala 355 Leu Asp As; Gir Let 43 Ph Glu S Leu S Asn C 100 Asp I Leu Lys Leu Asp 180 Ile Glu Asn lie Met 260 Leu Ile Trp Lys Leu 340 Gly Val Ser Glu Lys 420 Lys a Ser er 1 7 Ser 1 GIn I Ala jeu Arg Ser 165 ;lu ryr Ile Ser Leu 245 Leu Ala Ile Tyr Asp 325 Val Leu Leu Phe Ser 405 Pro Val Leu 0 ;er Arg ?ro ;In ;Gu Lys Lys Lys Met Val 230 Cys Val Ala Thr Ala 310 Phe Asp Lys Ser Gil 39C Arg Il Al 55 Tyr I Thr Asn Leu Ala 135 Val Ile Asn Leu Gin 215 Thr Arg Gly Arg Leu 295 Asn Ala Thr Glu Val 375 Val Gly B Ser Asp al Tyr ;lu 120 Leu Lys Arg Pro Ala 200 Leu Ile Pro Pro Tyr 280 Asp Lys Lys Thr Phe 360 Thr Leu Leu Tyr iu ;Gu Thr 105 Asp Lys GIn Asp Asn 185 Lys Ser Lys Glu Thr 265 Ser Asn Met Glu Gly 345 Ile Thr Gly Gly Let.
Glu 1 Giu b 90 Phe S Thr I Asp C Glu C Ser 170 Ser Gin Leu Arg Asp 250 Gly' Arg Tyr.
Lys Ile 330 His Asp Lys Ile Asn 410 Ser eu 15 et ;er Pro Glu 1u L55 Leu Val Ser Glu Tyr 235 Leu Val Met Arg Met 315 Glu Ser Gly Tyr As; 391 Let.
Va Asn GiU Arg Lys Lys Asn Leu Glu 125 Ala Asn 140 Glu Ile Lys Leu Asn Ile Gly Met 205 Leu Met 220 Phe Arg Asn Leu Gly Lys Lett Ala 285 Ile Gly 300 Ser Ile Ala Leu Gin Tyr Gly Tyr 365 Glu Asp 380 Thr Leu Phe Ser l Gly Gir i Val As 44 Glu Asp Val Leu Ala Gly Lys Thr Leu 110 Ala Asn Lys His Lys Lys Lys Asp Ile 160 Ile Gin Asn 175 Pro Gin Glu 190 Lys Ser Ser Pro Leu Arg Glu Val Leu 240 Arg Gin Lys 255 Thr Thr Thr 270 Lys Lys Tyr Ala Leu Glu Glu Ala Val 320 Glu Tyr Cys 335 Asp Lys Glu 350 Asn Ile Asp Met Lys Asp Ile Phe Thr 400 Leu Val His 415 Giu Val Pro 430 Cys Met Leu
I
425 Thr Asa Giu Tyr Le 440 Asn Pro Asn 455 Lys Glu Gin Ala INFORMATION FOR SEQ ID NO:1601: SEQUENCE CHARACTERISTICS: LENGTH: 355 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: POUS 96/09122a PEA/tS 15 DEC 1996.
1153 ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .355 (xi) SEQUENCE DESCRIPTION: SEQ ID 1le Met Ala Asp Ile Leu Ser Gin Giu Giu Ile Asp Val1 Ile Val Ala Glu Met Met Met Arg 145 Gin Tyr Val1 Gly Giu 225 Thr Gly Lou Lys Tyr 305 Lys Met Glu Val Pro Sen Arg Ile Ser Giy Ile 130 Giu Val Pro Aia His 210 Sen Asn Val Lys Val 290 Leu Glu Leu Glu Asp Gin Lys Asn Gin Leu Gly 115 Asp Ph.
Met Thr Gin 195 Ser Ile Ser Ser Glu 275 Ala Ala Val Giu Glu 355 Giu Arg Giu Leu Leu Pro 100 Thr Arg Ser Gin Ile 180 Asn Arg Leu Lys Val 260 Met Asn Sen Val Giu 340 Asn Val Sen Vai Gin Leu Ser Ser 70 His Sen Ser Pro Giy Vai Leu Lou Asp Ile 150 Ile Lou 165 Asp Aia Giu Ile Gly Met Ser Lys 230 Lys Sen 245 Asp Met Leu Asp Asp Giu Val Gly 310 Tyr Ser 325 Gin Arg Asp Thr Arg 55 Gin Val1 Thr Leu Gly 135 Giu Lys Lys Sen Met 215 Met Arg Met Leu Vali 295 Phe Giu Ang Ile Leu 40 Sen Val1 Asp Ser Giu 120 Giy Leu Giu Giu Ile 200 Asn Gly Asn Val Asp 280 Ser Gin Lys Gly Gin 25 Tyr Phe Sen Gin Phe 105 Ile Lys Asn Val1 Ser 185 Met Ile Sen Lys Ph.
265 Val Val Gly Giu Lys 345 Asn Asp Arg Ser Met 90 Asn Asn Giy Leu Trp 170 Sen Val Cys Arg Giu 250 Lou Gly Tyr Tyr Arg 330 Val Vai Gin Ph. Lys Ser Ile Ile Met 75 Thr Tyr Val Phe Pro Sen Ser Aia 140 Lou Asp 155 Ser Pro Ala Asn Vai Leu Tyr Pro 220 Asp Ph.
235 Lou Gin Gly Ala Asp Thr Val His 300 Arg Lys 315 Thr Lys Gly Asp Ala Lys Arg His Arg Giy Ser Ile 125 Tyr Thr Val Val1 Giu 205 Val Met Ala Val Ile 285 Lys Thr Giu Ile Lou Lys Pro Asp Sen Giu Met 110 Ala Asp Ile Val Val 190 Ile Ile Leu Leu Giu 270 Arg Lys Ile Ile Met 350 Lou Asp Asn Lys Ile Ph.
Lys Ph.
Gin Leu Glu 175 Gin Ile Ser Ser Leu 255 Leu Lou Lys Gin Lou 335 Lys Giu Ile Arg Met Val Lou Pro Pro Asn Ang 1 q.0 Met Ile Ile Ile Giu 240 Ser Ser Asn Arg Ile 320 Giu Ile INFORMATION FOR SEQ ID NO:i602: SEQUENCE CHARACTERISTICS: LENGTH: 297 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein PCT/US 96/091Zz IPEANUS 1 DEC1996 1154 (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...297 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1602 Gly 1 Ala I Ile 1 Ala Phe Lys Gin Asp Asp Val 145 Asn lie Glu Ala Leu 225 Arg Leu Leu Thr jys Ala Asn Asp rhr Glu Ser Arg 130 Ile Ala Thr Leu Thr 210 Glu Tyr Phe Glu Ser Asn Ile Leu Ala His Ile Gly 115 Phe Asp Ser Asp Phe 195 Tyr Leu Val Se Th 27 Met Pro I Thr Ala Asp Lys Ile 100 Glu Val Thr Asp Ala 180 Leu Glu His Arg r Gin 260 r Gly 5 5er Asn Gin Ala Ser 5 Lys Ser Tyr Ile Asn Cys Glu Asp Gly Cys 165 Tyr Ile Arg Tyr Glu 245 Ser Thr Ser Gly Ser Gly 70 Ile Glu Ile Glu Ala 150 Val Ala Ala Leu Leu 230 Arg Ile Phe Lys Leu 55 Leu Leu Ile Leu Glu 135 Gly Val Cys Asn Phe 215 Gly Lys Asp Phe I Gly C 40 Tyr I Ala His Glu Lys 120 Gly Ile Ile Ile Met 200 Lys Ala Ile Gin Asp Gly Lys Asn Ala Pro 105 Tyr Val Gly Val Lys 185 Val Val Ile Leu; Ile His I 10 Asn Val Lys Leu Leu 90 Gly Ile Leu Ala Thr 170 Ile Ala Ala Glu Arg 250 SAla Leu Asp Asn Phe Met Asn Lys Gly Asn Thr Lys Phe Gly Gly Asp 75 Lys Leu Ser Ser Thr 155 Thr Asn Gin Lys Asn 235 Lys Ser Lys Tyr Val Gly Cys Gly Ser 140 Thr Pro Ser Pro Asn 220 Ser SIle Leu Ser 45 Lys Ile I Glu 2 Leu Ala 125 'Leu Gin Asp Lys Lys 205 Asn Ser Ala Leu Leu 285 Asn Val ?he Ala Ile 110 31u Asp Ala Pro Asn 190 Glu Ile Leu Pro Val 270 Ile Gly I Gly Lys I 95 Pro Ala Tyr Phe Ser 175 Lys Gly Ala Leu Asn 255 SSer
L
Ser Val Val Leu Gly Leu Ile Leu 160 Ala Asp Arg Ser Lys 240 Asp Lys 265 Leu Glu Ile Pro Lys Glu Gly Lys Ser Phe Phe Lys Arg 290 Leu Leu Lys 280 Tyr Leu Gly 295 INFORMATION FOR SEQ ID NO:1603: SEQUENCE CHARACTERISTICS: LENGTH: 531 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori PTUS 96C/091 a IPEAlJS 1b DEC 19&6 1155 (ix) FEATURE: NAME/KEY: miscfeature LOCATION 1...531 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1603 Ile Ser Glu Phe Asn His Arg Ser Ala Pro Leu Ile 1 Asn Giu C Tyr Gin Lys 2 Lys 2 Ser I Ala His 145 Leu Lys Leu Leu Met 225 Cys Glu Asia Glu Thr 305 Ser Ala Glu Gin Asna 385 Glu Leu Giu Lys Val Thr Gin Tal Ile Asp Asn er Leu 130 Ser Pro Ile Glu Glu 210 Thr Glu Glu Arg Ala 290 Arg Lys Pro Pro Val 370 Asp Tyr Asia Ser Asn 450 Ser Ile Lys Lys Leu Ile Tyr Ala 115 Giu Val Gly Met Leu 195 Ala Ile Arg Tyr Glu 275 Ala Ala LyS Leu Leu 355 Gin Gin Gin Tyr Leu 435 His Arg ?he Tyr Val Gin T'hr Leu 100 Lys [yr Leu Phe Glu 180 Ala Lys His Leu Asp 260 Val Lys Glu Glu Giu 340 Met Glu GILu Tyr His 42( Gi Al 11 5 Lys Pro Ser Giu Ile Gin Leu Ala Lys Asn 165 Gin Val Glu Lys Gly.
245 Gly Val Asp Leu Ser 325 Giu Thr Ile Ala Ala 405 Tyr u Leu a Leu e Asp Lys Lys Leu Ala 70 Leu Glu Ser Leu Leu 150 Pro Phe Gly Ile Ser 230 Asn Thr Asp His Gly 310 Lys Gly Ser Giu Ile 390 Tyr Gly Phe Lys Val Ala Thr Val 55 ;Gn Cys Tyr Gin Ala 135 Ala Lys Lys Cys Ala 215 Lys Pro Glu Lys Glu 295 Leu Asn Giu Val Giu 375 Asr As Ph Gi Gi 45 Le Tyr C 2 Ser P 40 Ala P Asn I Ala Leu Leu 120 Glu C Gly Lys C Leu Glu 200 Ser Gly Asna Leu Asp 280 Giu Ile Lys Ile Val 360 Glu Phe i Ile e Tyr .u Asn 440 f Giu 5 u Leu ln 5 sn sp eu .hr Ser .05 Val Glu Tyr lu Tyr 185 Asp Phe Met Ser Ala 265 Tyr Ile Val Lys Ala 345 Ile Ser Gly Pro G11 421 Asp Al Tr 10 Asn Asn Glu I Leu C Asa I 90 Ala Giu Pro Leu Ser 170 Glu Ala Asn Gin Ser 250 Arg Ala Asn Val Met 330 Pro Lys Asp Ile Lys 410 Leu Ala x Ala p Asp er I Lys I Lys Glu 1 75 Lys Ile Ser T'yr I is 155 Val Glu Asp Pro Phe 235 His Leu Arg Val Ala 315 His Val Pro Ser Ala 395 Gin Asp Gly Pro His ;iu His Asp Arg Lys Lys 140 Asp Ala Pro Gly Lys 220 Pro Ala Tyr Ala Tyr 300 Lys Glu Ile His As; 380 Let Se Ty Il Ile A Thr A 3 Val I Leu L Arg I Ala L Pro S 1 Ile I 125 Pro P Asp V Ser I Ala C Phe I 205 Gly Tyr Asna Tyr Leu 285 Tyr Asp Gin Ser Ala 365 Tyr His Val r Gin e Gin 445 sn la 0 hr eu le eu er le he ral Phe Gin 190 Leu Ala fal Gln Arg 270 Asp Val Lys Leu Pro 350 Tyx Git Ly Le Al 43 Al Tyr Tyr Giu Leu Asp Glu Thr Lys Tyr Ile Val 175 Ser Glu Gin Ile Leu 255 Met Lys Ala Lys Glu 335 Gin Gly Lys s Gl u G1 41 a Le 0 a Le Val Leu Gly Glu Pro Ile Glu Asa Lys Ala 160 Trp Cys Lys Ile Val 240 Leu Lys Giu Phe Giu 320 Leu Lys Glu Asa y Leu 400 i Tyr u Giu u Phe Phe Leu Phe Gin Gly Val 460 Arg Gly Gin Asa Leu Tyr 9 1 Z u 996 1156 465 Val Gin Lys Leu 470 475 Asp Tyr Lys Ser Ser Gin Asn Tyr Gin Gin Ser 485 490 Ser His Tyr Ala Glu Phe Leu Arg Thr Gin Ala 500 505 Gin Ala Gly Ie Ilie Tyr Ala His Lys Arg Lou 515 520 525 Val.
480 His Lys Ala 495 Pro His Phe 510 Leu Glu Lys INFORMATION FOR SEQ ID No:160 4 SEQUENCE
CHARACTERISTICS:
LENGTH: 253 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL
SOURCE:
ORGANISM: Holicobacter pylori (ix) FEATURE: NAME/KEY: misc..feature LOCATION .253 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:160 4 Leu Ser Thr Ala Tyr Gin Ala Val Glu Lou His Trp Ph. Leu Lys Ala 1 5 10 Val Leu Val Leu Glu Arg Sen Pro Sen Ser Pro Glu Ile Lys Gly Ile 25 Trp Asp Ang Asp Tyr His Thr Pro Ile Thn Ser Sor Ph. Thr Leu Asp 40 Val Ser Tyr Asp Asn Thr Asp Asp Tyr Tyr Phe Pro Ang Asn Gly Val 55 Ile Ph. Sen Ser Tyr Ala Thr Met Sen Gly Lou Pro Ser Ser Gly Thn 70 75 Leu Asn Sor Tnp Asn Gly Lou Gly Gly Asn Val Arg Asn Thr Lys Val 90 Tyr Gly Lys Ph. Ala Ala Tyr His His Lou Gin Lys Tyn Lou Lou Ile 100 105 110 Asp Leu Ile Ala Arg Ph. Lys Thr Gin Gly Gly Tyr Ile Ph. Arg Tyr 115 120 125 Asfl Thr Asp Asp Tyr Lou Pro Lou Asn Son Thr Ph. Tyr Mot Gly Gly 130 135 140 Val Thn Thn Val Arg Gly Ph. Arg Asn Gly Ser Ile Thr Pro Lys Asp 145 150 155 160 Glu Ph. Gly Lou Trp Lou Gly Giy Asp Gly Ile Ph. Thn Ala Son Thr 165 170 -175 Glu Lou Son Tyr Gly Vai Leu Lys Ala Ala Lys Met Ang Lou Ala Trp 180 185 190 Ph. Phe Asp Ph. Gly Ph. Lou Thr Pho Lys Thr Pro Thr Ang Gly Son 195 200 205 Ph. Ph. Tyr Asn Ala Pro Thr Thr Thn Ala Asn Ph. Lys Asp Tyr Gly 210 215 220 Val Val Gly Ala Gly Ph. Gilu Ang Ala Thr Trp Arg Ala Sen Thn Gly 225 230 235 240 Leu Gin Ile Glu Tnp Ile Sen Pro Met Gly Pro Tnp Cys 245 250 POT/US 9 6 091 Z IPENUS 18 DEC 1996 1157 INFORMATION FOR SEQ ID NO:1605: SEQUENCE
CHARACTERISTICS:
LENGTH: 86 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...86 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1605 Ala Arg Ile Met Leu Asp Lys Arg Ile Lys Thr Leu Leu Leu Phe Phe 1 5 10 Gly Leu Asn Met Val Cys Leu Ser Val Ser Phe Thr Asn Lys Pro His 25 Leu Cys Phe Trp Phe Leu Val Leu Gly Cys Tyr Leu Val Tyr Glu Trp 40 Gin Lys Lys Gln Lys Lys Asp Phe Gln Ser Ala Lys Ser Leu Lys Phe 55 Asp Ser Val Ser Giu Leu Glu Lys Asp Leu Asn Met Glu Val Thr Asn, 70 75 Asp Glu Trp Asp Thr His INFORMATION FOR SEQ ID NO:1606: SEQUENCE CHARACTERISTICS: LENGTH: 272 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...272 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1606 Ser Arg Ser Val Glu Met Asn Tyr Pro Asn Leu Pro Asn Ser Ala Leu 1 5 10 Glu Ile Ser Glu Gln Pro Glu Val Lys Glu Ile Thr Asn Glu Leu Leu 25 Lys Gln Leu Gln Asn Ala Leu Arg Ser Asn Ala His Phe Ser Glu Gin 40 Val Glu Leu Ser Leu Lys Cys Ile Val Arg Ile Leu Glu Val Leu Leu 55 Ser Leu Asp Phe Phe Lys Asn Ala Asn Glu Ile Asp Ser Ser Leu Arg 70 75 Asn Ser Ile Glu Trp Leu Thr Asn Ala Gly Glu Ser Leu Lys Leu Lys 1] C; PCT/US 96/0912.2 1158 Met Ala Ile Thr 145 Asn Ile Thr Giu Lys 225 Asn Ala Lys Asn Lys 130 Arg Ala Thr Gin Ile 210 Giu Asn Lys Glu Ty'r 100 Glu Gin 115 Ser Giu Leu Leu Asn Asri Gin Ala 180 Ala Ile 195 Ser Asn Ser Ala Ile Thr Lys Thr 260 GiU Giu Ile Thr Gin 165 Lys Thr Asn Thr Gin 245 Asp Arg Val1 Lys Ser 150 Ile Asn Asn Gin Thr 230 Giu His Phe Thr Lys 135 Tyr Thr Asn Ile Thr 215 Gin Lys Tyr Phe Ser 105 Asn Thr 120 Leu Giu Gin Ile Lys Asn Ala Asn 185 Thr Glu 200 Gin Ala Ile Asn Thr Gin Gin Asn 265 Giu Leu Asn Phe Lys i7 0 Asn Aia Ile Ala Aia 250 Ile Phe Asn Gin Leu 155 Thr Glu Lys Thr Asn 235 Thr Asp Asn Aia Leu 140 Asn Gin Ile Thr Asn 220 Lys Ser Phe Thr Asn 125 Ile Gin Ser Ser Asn 205 Ile Gin Giu Phe Ser 110 Ala Giu Ala Leu Asn 190 Ala Asn Glu Ile Glu 270 Met Giu Thr Arg GiU 175 Thr Asn Glu Aia Thr 255 Phe INFORMATION FOR SEQ ID NO:1607: SEQUENCE CHARACTERISTICS: LENGTH: 443 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 443 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1607 1Gly Leu Ser Val Leu Giu Arg Tyr Ala Asn Glu Giu Met Lys Ala Leu Trp Val Giu Ile Ala Ser Leu Asn Gly 145 Giu Arg Ile Lys Ser Asp Leu 115 Ala Phe Gin Ala Cys; Thr Leu Cys 100 Ile Leu Gly Thr Trp Leu Thr Gly Ile Gin Giu Giu Giu Leu 40 Ala Asp Ser Ala Vali 120 Asp Thr Thr 25 Gly Phe Leu Arg Met 105 Lys Thr Phe Gin Asn Ile Phe 90 Ala Asn Leu Gly Val Asp Arg Thr Tyr Met Glu 125 Gly Leu Giu Sen Ile Thr Gly Thr 110 Thr Arg Ala Lys Asp Lys Cys Ile Lys Leu Ser Leu PCT/1i 9 610 Q9,2 1159 Ala Phe Ala Thr Leu 225 Val Ala Asn Ser Asp 305 Ile Leu Gly Leu Ile 385 Leu Asn Asn Asp Ile Pro Ala 210 Ala Asn Phe Pro Phe 290 Met Thr Val Leu Ser 370 Trp Phe Glu Val1 Gilu Ser Leu 195 As n Cys Ile Ser Ile 275 Thr Ser Ser Val1 Val1 355 Arg Giu Leu Ser Gly 435 Ile Vali 180 Glu Ile Asp Arg Ala 260 Leu Thr His Asp Tyr 340 Phe Giu Val1 Asri Giu 420 Ala Lys 165 Trp Leu Ser Leu His 245 Giy Ser Pro Ser Phe 325 Pro Ser Giu Leu Ala 405 Ile Ile Arg Ala Glu Asn Ala 230 Leu Gin Giu Met Ser 310 Met Lys Gin Ser Gin 390 Leu Arg Phe His Leu Ile Ser Giu Leu 200 Gin Val 215 Leu Leu Gin Arg Lys Gly Asn Ile 280 Leu Giu 295 Val Giu Leu Ser Asn Met Arg Val 360 Tyr Ser 375 Gin Gly Leu Asn Ala Cys Lys Arg 440 Lys Gly 185 Aia Ile Ala Ser Ser 265 Thr Asn Arg Arg Leu 345 Leu Ile Ala Asp Phe 425 Val1 Ala Leu 170 Gly Leu Cys Gly Gin Arg Ser Ser 235 Giu Val 250 Ser Ala Gly Leu Val Ala Phe Ala 315 Leu Asn 330 Lys Asn Leu Giu Val Gin Phe Lys 395 Glu Arg 410 Asp Tyr Phe Gly Asp Gly Phe Asp 220 Cys Tyr Met Cys Leu 300 Leu Ser Leu Leu Glu 380 Asn Lou Ser Leu Thr Asn Phe 190 Leu Gly 205 Arg Ty'r Giu Lys Giu Val Pro His 270 Arg Val 285 Trp His Pro Asp Val Ile Ala Leu 350 Pro Lys 365 Asn Ala Ala Asp Lys Lys Tyr Tyr 430 Met 175 Ala Leu Ala Ile Giu 255 Lys Ile Giu Leu Giu 335 Ser Lys Met Giu Tyr 415 Thr Giu His Lys Arg Ala 240 Glu Arg Arg Arg Phe 320 Asn G ly Gly Lys Asn 400 Leu Lys INFORMATION FOR SEQ ID NO:1608: SEQUENCE CHARACTERISTICS: LENGTH: 97 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .97 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1608 Asn Asp Ser Gly Ser Lys His Phe Ile Leu Pro Phe Leu Thr Lou Leu 1 5 10 Leu Gin Met Tyr Lou Ser Arg Thr Arg Giu Tyr Met Ala Asp Sen Gly 25 Ala Ala Phe Leu Met His Asp Asn Lys Pro Met Ile Arg Ala Leu Gin 40 Lys Ile Ser Asn Asp Tyr Thr Asn Asn Asp Tyr Lys Giu Ile Asp Lys PCT/US 96/091 2.
1160 55 Asn Ser Thr Arg Ser Ala Ala Tyr Leu Phe Asn Ala Glu Met Phe Ser 70 75 Thr His Pro Ser Ile Lys Asn Arg Ile Gln Ser Leu Arg Lys Arg Val 90 Ile INFORMATION FOR SEQ ID NO:1609: SEQUENCE CHARACTERISTICS: LENGTH: 180 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...180 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1609 Met Glu Lys Phe Phe Asn Gln Phe Phe Glu Asn Ile Gly Glu Asp Lys 1 5 10 Asn Arg Glu Gly Leu Lys Glu Thr Pro Lys Arg Val Gin Glu Leu Trp 25 Lys Phe Leu Tyr Lys Gly Tyr Lys Glu Asp Pro Arg Val Ala Leu Lys 40 Ser Ala Tyr Phe Gin Gly Val Cys Asp Glu Met Ile Val Ala Gin Asn 55 Ile Glu Phe Tyr Ser Thr Cys Glu His His Leu Leu Pro Phe Phe Gly 70 75 Asn Ile Ser Val Gly Tyr Ile Pro Lys Glu Lys Ile Val Gly Ile Ser 90 Ala Ile Ala Lys Leu Ile Glu Ile Tyr Ser Lys Arg Leu Gin Ile Gin 100 105 110 Glu Arg Leu Thr Thr Gin Ile Ala Glu Thr Phe Asp Glu Ile Ile Glu 115 120 125 Pro Arg Gly Val Ile Val Val Cys Glu Ala Lys His Leu Cys Met Ser 130 135 140 Met Gin Gly Val Gin Lys Gin Asn Ala Ile Ile Lys Thr Ser Val Leu 145 150 155 160 Arg Gly Leu Phe Lys Lys Asp Pro Lys Thr Arg Ala Glu Phe Met Gin 165 170 175 Leu Leu Lys Ser 180 INFORMATION FOR SEQ ID NO:1610: SEQUENCE CHARACTERISTICS: LENGTH: 308 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES POT/US1 9 6/091? 2.
uA 1161.
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .308 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1610 Val Ile Ile Leu 1 Giu Glu Asri Ser Lys Asp Thr Ala Ser 145 Ile Thr Ala Ile Met 225 Asp Son Thr Cys Gly Gly Lou Ile Asp Leu Leu 130 Arg Lys Pro Lys Asn 210 Gly Giu Pho Leu Giu Pho Gly Val1 Ala Leu His 115 Asn Ilie Gly Leu Leu 195 Asp Leu Lys Val Lys Arg His Lys Gly Leu Pro 100 Ala Thr Ile Met Asn 180 Ile Giu Cys Giu Asn 260 Thr Gly 5 Phe Pro Arg Lys Ser Cys Lys Tyr Val1 Ile 165 Leu Ser Giu Phe Ser 245 Leu Giu Giu Tyr Phe Lys 70 Ile Met Tyr Ser Giu 150 Leu Giu Ala Lou Gin 230 Gly Lou Ile Met Ser Asn Pro Asn Lou Ser Ph. Tyr Ser Lou Arg 55 Asp Giu Asp Asp Ph.
135 Lou G ly Gin Ser Leu 215 Val Lys Gly Lou Phe Giu 40 Pro Tyr Cys Asn Glu 120 Giu Val1 Gin Leu Leu 200 Lys Leu Thr Lou Asn 280 Leu 25 Lys Lys Sor Leu Ala 105 Thr Leu Lys Ala Thr 185 Ile Trp Asp Thr Lys 265 Asp Lys Ala Leu Asn His 90 Ile Thr Leu Ile Leu 170 Ph.
Met Lou Asp His 250 Lys Leu Asn Ph.
Phe Gin 75 Thr Leu Ala Ser Lou Asp Leu Giy Gin Ile 235 Lou Ala Asn His Phe Lou Gin Tyr Arg Val Asn 14b Sor Cys His Lou Ala 220 Ile Asp Sen Ala Lou 300 Tyr Giu Ala Thr Ser Arg Lou 125 Ser Ala Tyr Giu Val1 205 Phe Asp Son Gly Lou 285 Lou Met Val Giu Lou Asn 110 Ile Lou Asn Phe His 190 Ala Gly Val Ala Tyr 270 Glu Cys Asn His Lou Val Leu Lou Cys Tyr Phe Ile His His Pro Giy Asp Lou Glu Gly Gly, 160 Giu Asn 175 Lys Thr Sen Gly Lou Lys Thr Gin 240 Lys Asn 255 Ala Gin Pro Thr 275 Tyr Lys 305 Lou Sor Lou Gin Glu Asn 290 295 Gly Lys Thr Lou Asn Ala Lou Asn Thr Lou Pho INFORMATION FOR SEQ ID NO:i611: SEQUENCE CHARACTERISTICS: LENGTH: 347 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni PC TUS 96/091ZZ 116 2 p .uDtu'0i996 (ix) FEATURE: NAME/KEY: misc_feature LOCATION .347 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1611 Leu Leu Asn Thr Ser Lys Lys Lys Arg Asn Leu Asn 1 Cys Arg Arg Phe Gly Thr Gin Asp Leu 145 Tyr Glu Asp Arg Ile 225 Arg Gin Arg Asp Thr 305 Ala Leu Lys Leu Ile Ile Ile Asn Pro 130 Leu Ile Ser Arg His 210 Met Lys Ile Thr Asn 290 Asn Tyr Lys Glu Lys Gly Ala Val Phe 115 Ser Glu Ile Asn Asp 195 Asn Leu Asn Ile Arg 275 Lys Asn Leu Gly Lys Thr Leu Leu Met 100 Ser Lys Leu Asn Ser 180 Glu Asp Leu Ser Leu 260 Glu Pro Asp Phe 5 Val Met Ile Met Asn Ala Leu Val 70 Phe Lys Phe Val Ser Ile Val Leu Leu Glu 150 Ala Pro 165 Leu Ile Leu Lys Ile Arg Val Ala 230 Gly Ala 245 Pro Phe Tyr Met Met Ile Tyr Lys 310 Asn Ala 325 Ser Leu Arg Thr Val 55 Asp Leu Val Met Ser 135 Glu Tyr Ala Ala Leu 215 Asn Asn Leu Ala Arg 295 Glu Glu Arg Ala Asn 40 Leu Ala Met Ala Leu 120 Ser Ala Met Leu Val 200 Thr Phe Leu Thr Asp 280 Ala Ile Met Lys Arg 25 Phe Thr Ile Thr Phe 105 Ser Lys Lys Asn Thr 185 Ile Met Ser Ala Leu 265 Ser Leu Asp Phe Arg 345 10 Cys Glu Thr Arg Phe 90 Val Gly Glu Leu Ala 170 Ser Ala Cys Val Arg 250 Leu Gly Gin Lys Ser 330 Val Ser Lys Tyr Ile 75 Gin le Asp Asn His 155 Phe Ala His Val Tyr 235 Met Leu Ala Lys Asn 315 Thr Ile Lys Ile Cys Asn Ile Ile Glu Gin 140 Phe Ala Leu Glu Gly 220 Phe Ile Gin Ala Ile 300 Ser His Trp Lys Ile Ala Ala Phe Leu Tyr 125 Ile Glu Ser Ile Leu 205 Ile Phe Leu Met Phe 285 Ser Thr Pro Asn Ser Ala Ile Asn Pro Val 110 Lys His Pro Gly Glu 190 Ser Leu Met Trp Tyr 270 Leu Asn Arg Ser Phe Ser Gin Phe Asp Thr Cys Leu Arg Lys Trp 175 Arg His Ser Gly Val 255 Leu Met Asp Ser Ile 335 Thr Met Asn Ala Leu Ile Ile Ile Leu Leu 160 Asp Leu' Ile Asn Asn 240 Leu Ser His Tyr Ala 320 Lys Asn Arg Ile Gin 340 INFORMATION FOR SEQ ID NO:1612: SEQUENCE CHARACTERISTICS: LENGTH: 65 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE:
I
PCT/US 9 6/0912 2 1163 ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...65 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1612 Thr Gln Pro His Lys Asn Lys Arg Leu Asn Lys Arg Leu Asn Lys Arg 1 5 10 Leu Asn Lys Arg Leu Asn Lys Arg Leu Asn Lys Arg Leu Asn Lys Arg 25 Leu Asn Lys Lys Leu Asn Lys Ser Lys Lys Lys Lys Ile Ser Leu Asn 40 Lys Thr Val Ser Arg Pro Phe Lys Thr Ile Lys Lys Pro Pro Gln Pro 55 Pro INFORMATION FOR SEQ ID NO:1613: SEQUENCE CHARACTERISTICS: LENGTH: 138 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...138 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1613 Gly Val Asn Met Leu Ile Leu Gly His Pro Leu Ile Pro Ser Ala Arg 1 5 10 Phe Val Phe Ile Lys Asn Thr Asp Ala Ile His Ser Ser Ala Asn Asn 25 Asp Ile Val Cys Phe Glu Ala Asn Pro Lys Asn Leu Glu Leu Ala Gin 40 Tyr Cys Cys Glu Asn Gly Val His Phe Ser Val Ile Phe Leu Ser His 55 Lys Ile Glu Thr Asp Thr Phe Phe Leu Phe Asn Ala Phe Lys Pro Leu 70 75 Tyr Cys Ile Phe Lys Asp Ile Lys Gin Ala Ile Leu Ala Gin Gln His 90 Ala Thr Asn Tyr Leu Leu Asp Ser Lys Ile Leu Phe Ser Met Asp Phe 100 105 110 Asn Asp Thr Glu Ser Trp Glu Ile Cys Ala Lys Asn Gln Ile Asp Gly 115 120 125 Val Ile Ser Lys Asp Ser Leu Leu Leu Lys 130 135 INFORMATION FOR SEQ ID NO:1614: SEQUENCE CHARACTERISTICS: LENGTH: 134 amino acids TYPE: amino acid PCT/US 96/0912.
IPEA/US i DEC1996 1164 TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...134 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1614 Phe Lys Cys Asn Leu Lys Arg Arg Ser Ala Leu Lys Leu Leu Val Val 1 5 10 Asp Asp Ser Ser Thr Met Arg Arg Ile Ile Lys Asn Thr Leu Ser Arg 25 Leu Gly Tyr Glu Asp Val Leu Glu Ala Glu His Gly Val Glu Ala Trp 40 Glu Lys Leu Asp Ala Asn Ala Asp Thr Lys Val Leu Ile Thr Asp Trp 55 Asn Met Pro Glu Met Asn Gly Leu Asp Leu Val Lys Lys Val Arg Ala 70 75 Asp Asn Arg Phe Lys Glu Ile Pro Ile Ile Met Ile Thr Thr Glu Gly 90 Gly Lys Ala Glu Val Ile Thr Thr Leu Lys Ala Gly Val Asn Asn Tyr 100 105 110 Ile Val Lys Pro Phe Thr Pro Gln Val Leu Lys Glu Lys Leu Glu Val 115 120 125 Val Leu Gly Thr Asn Asp 130 INFORMATION FOR SEQ ID NO:1615: SEQUENCE CHARACTERISTICS: LENGTH: 280 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION-1...280 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1615 Arg Val Met Ala Val Arg Ile Met Ala Thr Val Trp Thr Asn Ser Cys 1 5 10 Lys Glu Phe Gly Leu Val Ser Leu Phe Leu Ser Leu Leu Val Leu Val 25 Val Val Gly Arg Phe Phe Ile Lys Gly Ala Phe Tyr Gly Leu Lys Asn 40 Gly Val Leu Gly Met Asp Leu Ser Val Ser Phe Gly Ala Leu Ser Ala 55 Phe Val Tyr Ser Leu Tyr Ala Met Leu Val Ser Gin Glu Thr Tyr Phe 70 75 .K UT'e PCT/US 9 6 /091 2 1165 Glu Ala Ser Ser Thr Ile Leu Thr Leu Val Phe Gly Ser Lys Phe Leu 90 Glu Leu Lys Ala Arg Leu Phe Ala Asn Glu Lys Cys Leu Ala Leu Glu 100 105 110 Ser His Glu Ile His Ser Val Ile Val Val Glu Asn Gly Lys Gin Ile 115 120 125 Glu Lys His Pro Lys Asp Val Ala Ile Gly Ser Val Val Trp Val Pro 130 135 140 Ser Gly Ala Lys Ile Ala Leu Asp Gly Val Leu Leu Asn Ser Ala Ser 145 150 155 160 Val Asp Ala Ser Leu Ile Ser Gly Glu Phe Lys Pro Leu Glu Leu Gly 165 170 175 Val Asn Asp Pro Ile Leu Gly Gly Tyr Val Asn Val Gly Val Pro Phe 180 185 190 Ser Tyr Gin Val Ser Ala Thr Phe Gin Asn Ser Arg Leu Ser Ser Leu 195 200 205 Leu Glu Thr Leu Lys Lys Ser Phe Leu Glu Lys Pro Leu Ile Glu Ser 210 215 220 Ser Ala Asn Lys Ile Ala Asp Ile Phe Ser Lys Ala Val Leu Phe Leu 225 230 235 240 Ala Phe Val Ser Phe Leu Leu Trp Gin Phe Gly Leu Gly Gly Asn Phe 245 250 255 Glu Lys Ala Leu Met Val Cys Ile Ser Val Leu Val Ile Ser Cys Pro 260 265 270 Cys Ala Phe Ala Arg Leu Arg Pro 275 280 INFORMATION FOR SEQ ID NO:1616: SEQUENCE CHARACTERISTICS: LENGTH: 196 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...196 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1616 Arg Ala Ser His Lys Leu Pro Leu Arg Val Arg Ser Ala Thr Pro Ile 1 5 10 Ala Leu Val Ile Gly Val Phe Lys Asn Pro Leu Ile Val Phe Lys Glu 25 Ala Leu Phe Leu Glu Thr Leu Ala Lys Val Lys Lys Ile Phe Ile Asp 40 Lys Thr Gly Thr Leu Thr Gin Lys Glu Val Leu Leu Lys Glu Lys Ile 55 Ile His Glu Glu Phe Asp Glu Arg Leu Leu Lys Ser Leu Leu Lys Thr 70 75 Arg Glu His Leu Ala His Asn Ala Ile Leu Lys Thr Leu Asp Gly Asp 90 Glu Val Asp Leu Glu Lys Ile Glu Phe Phe Ala His Gly Leu Lys Ala 100 105 110 Ser Tyr Gin Asn Glu Thr Leu Leu Val Gly Ser Leu Lys Phe Leu Asn 115 120 125 Ala Met Gly Val Asp Leu Lys Val Lys Glu Ser Ala Asn Ile Met Val PCT/US 96/0912.2 1166 130 135 140 Gly Phe Ala Lys Asn Lys Thr Leu Cys Ala Leu Phe Ile Leu Glu Glu 145 150 155 160 Arg Leu Lys Ala Asn Ala Lys Glu Val Ile Gln Ala Leu Gin Asn Gin 165 170 175 Gly Leu Glu Leu Glu Ile Leu Ser Gly Asp Asn Glu Ser Ser Val Lys 180 185 190 Glu Cys Ala Lys 195 INFORMATION FOR SEQ ID NO:1617: SEQUENCE CHARACTERISTICS: LENGTH: 667 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...667 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1617 Thr Pro Thr Lys Ala Pro Lys Ile Val Gin Glu Gin Val Thr 1 Leu Ile Val Val Thr Asn Leu Val Asn 145 Asp Arg Val Val Asp 225 Thr Val Ser Asn Ser Ser Leu Leu Lys 130 Leu Thr Ser Lys Arg 210 Lys Tyr 5 Ser Thr Phe Ser Tyr Glu Leu Tyr Trp Asn Leu Pro Ile Gly Trp Ser Asp Leu 100 Gly Val Asp 115 Asp Tyr Glu Ser Leu Glu Gly Gly Gly 165 His Gly Tyr 180 Lys Glu Gly 195 Leu Ala Pro Glu Val Val Lys Val Leu 245 Met Ser Ala Lys 70 Ala Lys Gly Val Gin 150 Val Ile Ala Lys Gly 230 Ser Gly Arg 55 Asp Tyr Val Val Thr 135 Val Ile Gin Ile Pro 215 Gly Ile Leu 40 Asp Ala Gin Leu Ser 120 Leu Ala Leu Ser Pro 200 Arg Ile Ile 1 Ala A 25 Ile Arg Lys Tyr Gin 105 Glu Gin Asn Glu Leu 185 Leu Arg Val Lys 0L Asn Ile Asp Thr Val Tyr Pro Arg Gly Tyr Ile Ile Val Leu Glu Val Glu Ile 75 Ala Leu Ser 90 Asp Phe Tyr Val Ala Ser Asn Asp Ser 140 Ala Ile Lys 155 Asn Gly Phe 170 Asn Asp Leu Lys Ile Lys Gly Ala Ala 220 Met Val Arg 235 Glu Lys Ile 250 Phe Gin Gly Ser Tyr Val 125 Leu Asn Glu Glu Asp 205 Asn Tyr Ala Lys Asp C Leu Asn Ser Asp Asp Ser 1 Arg Tyr 110 Gly Gly Ile Arg Ser Asn Lys Ile 175 Glu Ile 190 Ile Ala Leu Asn His Ala Thr Leu 255 Arg Ser 270 Gly Arg Ser 1 ys Ala Phe Tyr Asn 160 Ile Val Ser Gly Asp 240 Gin Glu Lys Ala Ala Ser Asn Pro 260 Asp Val Lys Ile Thr 265 Ser Val Tyr Asp
~T.
PCT/US 96/0912.2 ouEGi996 1167 Leu Ser Ser 305 Phe Gly Met Asn Gly 385 Ile Tyr Ile Glu Ser 465 Val Glu Thr Ser Lys 545 Ile Leu Lys Met Asn 625 Leu Asn Ile Glu 275 Val Ile 290 Ala Leu Leu Leu Gly Ile Val Glu 355 Thr Gin 370 Ala Ile Phe Ala Thr Lys Val Pro 435 Ser Glu 450 Leu Arg Leu Gly Phe Ile Ile Asn 515 Asn Ala 530 Val Gly Glu Thr Ser Tyr Gly Leu 595 Leu Leu 610 Asp Thr Lys Thr Gly Tyr Lys Val Val Met Ala 340 Asn Arg Phe Leu Thr 420 Val Ser Val Leu Pro 500 Gly Ala Arg Tyr Lys 580 Thr Thr Asp Leu Tyr 660 Gly Leu Val Arg 325 Ile Ala Val Phe Thr 405 Phe Leu Pro Val Gly 485 Gin Val Ile Ala Ile 565 Glu Asn Gly Lys Lys 645 Ile lie Val Ile 310 Tyr Ala His Asn Ala 390 Gly Ala Met Val Leu 470 Gly Ile Gly Lys Asn 550 Glu Val Ser Ile Leu 630 Glu Thr Asp Ile 295 Ile Phe Ile Lys Ala 375 Leu Gin Met Val Asn 455 Lys Leu Asn Ile Gin 535 Thr Leu Arg Trp Arg 615 Gin Ser Leu Asn 280 Ile Thr Asn Arg His 360 Ile Met Glu Leu Trp 440 Ala Phe Val Glu Asp 520 Leu Ser Lys Asp Thr 600 Thr Glu Leu Asp Leu Ala Leu Ile Ala 345 Leu Met Ile Glu Val 425 Leu Phe Arg Val Gly 505 Thr Asp Thr Pro Lys 585 Tyr Pro Leu Ser Leu 665 Ile Ile Pro Glu 330 Met Gin Gin Ile Lys 410 Gly Ile Phe Tyr Ala 490 Val Ala Phe Asp Gin 570 Leu Pro Leu Ala Gly 650 Glu His Phe Leu 315 Ala Val His Gly Val 395 Leu Ala Lys Met Ala 475 Tyr Ile Leu Val Ala 555 Asn Glu Ile Gly Ile 635 Phe Arg Thr Leu 300 Ser Ser Asp Ile Val 380 Val Phe Leu Gly Lys 460 Phe Lys.
Met Glu Lys 540 Ala Glu Lys Arg Ile 620 Leu Ala Leu 285 Leu Val Ile Ala Asp 365 Lys Ser Ala Leu Arg 445 Ile Leu Lys Tyr Tyr 525 Gin Gly Trp Thr Gly 605 Lys Met Glu Ile His Cys Met Ala 350 Thr His Phe Pro Ser 430 Ile Tyr Ile Leu Met 510 Leu Val Leu Lys Leu 590 Arg Leu Glu Arg Glu Glu Phe Arg Ile Ser 320 Ser Leu 335 Ile Val Arg Asp Val Gly Leu Pro 400 Leu Ala 415 Ile Thr Leu Glu Gly Val Ala Ser 480 Asn Trp 495 Pro Val Lys Lys Phe Gly Gly Met 560 Glu Lys 575 Gin Leu Thr Asp Tyr Gly Gin Gin 640 Ser Asn 655 INFORMATION FOR SEQ ID NO:1618: SEQUENCE CHARACTERISTICS: (ii) (iii) (vi) LENGTH: 95 amino acids TYPE: amino acid TOPOLOGY: linear MOLECULE TYPE: protein HYPOTHETICAL: YES ORIGINAL SOURCE: ORGANISM: Helicobacter pylori PETUS 96/091 2i 2 IP~~tU lbDEC 1996 1168 Arg 1 Leu Val Ser Glu Asn (ix) FEATURE: NAME/KEY: misc_feature LOCATION (xi) SEQUENCE DESCRIPTION: SEQ ID NO:i618 Asn Val Giu Ala Arg Tyr Tyr Tyr Gly Asp 11 5 His Ala Gly Val Leu Gin Glu Phe Ala His P1, Ala Ser Leu Asn Thr Phe Lys Ile Asn Ala A Thr Tyr Ala Arg Ala Met Met Gly Gly Giu L 55 6 Val Ph. Leu Asn Leu Gly Val Val Tyr Leu H 70 Ala Ser His Phe Ala Ser Asn Leu Gly Met A INFORMATION FOR SEQ ID NO:1619: Wi SEQUENCE CHARACTERISTICS: LENGTH: 211 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .211 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:16i9 1Lys Pro Thr Asn Val Trp Ala Asn Ala Ile Gly Gly Ala Sen Ph.
Giy Asn Glu Leu Tyr Ala Tyn 145 Val Ala Gly Leu Asn Ph.
Asn Leu Phe 130 Asn Ala Thr Sen Asn Ser Ala Asp Phe Ala 115 Phe His Lou Trp Asn Gly Ser Asn Ph.
Lys 100 Tyr Arg Leu Lys Lys 180 Ala Asn Ph.
Phe Glu Sen Sen Asn Gly As n 165 Ser Val 5cr Gly 70 Ala Thr Ala Ala Sen 150 Gly Leu Glu Asn Val Gin Leu Thn Leu 135 Thr Ala Tyr Ala 40 Gin Tyr Gly Leu Ala 120 Val Asn Sen Gly Thr Sen 25 Ile Val Gly Ala Asn Sor Ser Arg Ph.
75 Ala Leu Gly 90 Gin Asp Leu 105 Ang Ala Ser Lou Lys Pro Phe Lys Ser 155 Ser Gin His 170 Ala Gly Leu Ph.
Sen Asn Tyr Sen 140 Asn Qly Ph.
Asn Ala Asp Gin Gly 125 Val Ser Ser Leu Asn Val Asp Ala Gly Sen Tyr Sen Gly Ala Asn His Pro Gin Ser Sen Sen Tyr Asn 110 Tyr Asp Ph.
Gly Val Sen Gin Sen Gin Leu Ph. Asn Ala Asn 175 Ph. Ile Arg Val Ilie Ile Gly Thn Leu His 190 PCT/US 9 6 /091 2 SiujcG1996 1169 Cys Met Arg Glu Phe Tyr Lys Ser Ser Leu Thr Leu Asp Arg Met Met 195 200 205 Trp Arg Leu 210 INFORMATION FOR SEQ ID NO:16 2 0: SEQUENCE
CHARACTERISTICS:
LENGTH: 78 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...78 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1620 Asn Lys Ile Leu Ala Ser Glu Leu Glu Phe Lys Phe Leu Ile Lys Gly 1 5 10 15 Val Ile Met Ala His His Glu Glu Gin His Gly Gly His His His His 25 His His His Thr His His His His Tyr His Gly Gly Glu His His His 40 His His His Ser Ser His His Glu Glu Gly Cys Cys Ser Thr Ser Asp 55 Ser His His Gin Glu Glu Gly Cys Cys His Gly His His Glu 70 INFORMATION FOR SEQ ID NO:1621: SEQUENCE
CHARACTERISTICS:
LENGTH: 345 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...345 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1621 Gly Val Leu Ile Arg Thr Pro Lys His Leu Thr Lys Gin Glu Ser Val 1 5 10 Asn Leu Gly Ala Tyr Tyr Thr Pro Pro Tyr Leu Val Asp Cys Ala Tyr 25 Lys Leu Leu Lys Lys His Val Gly Ile Glu Asn Tyr Thr Leu Leu Asp 40 Thr Ala Cys Gly Asn Lys Glu Phe Leu Lys Leu His His Pro Lys Lys PCT/IJS 9610912.2 ivPAMs 18 DEC 1996 1170 Ile Leu Leu Lys Leu Leu 145 Lys Leu Giu Ala Cys 225 Asn Asp Giu Ile Asn 305 Ala Phe Gly Ala Asp Ala Asn Pro Ile Ile Val 100 Gin Asp Ile 115 Lys Ser Arg 130 Lys Pro Ala Giu Ala Asn Leu Asp Ala 180 Phe Pro Ile 195 Gly Ile Arg 210 Leu Asn Asp Ala Lys Lys Ile Asn Ala 260 Asn Ala Val 275 His Tyr Phe 290 Leu Asp Ile Phe Leu Lys Gln Gly His 340 Ile Lys Gly Lys Asp Phe Phe 165 Phe Val Arg Phe Val1 245 Leu Arg Lys Ile Asp 325 Pro Asp 70 Arg Asn Asn Leu Ile 150 Lys Val Ile Phe Asp 230 Gly Lys Ile Glu Ile 310 Lys Cys 55 Pro Glu Pro Lys G ly 135 Cys Gin Val1 Ala Val1 215 Tyr Ala Arg Ser Ile 295 Asp Arg Glu Lys Asn Pro Asp 120 Ile Val Leu Ser Leu 200 Phe Ile Cys Asn Gin 280 Ala His Ala Phe Cys Tyr Tyr 105 Phe Ser Leu Lys Ser 185 Tyr Pro Ala Val1 Lys 265 Asp Pro Phe Arg Asp 345 Asp Giy 90 Asn Ile Phe His Leu 170 Lys Glu Thr Asn Gly 250 Thr Lys Lys Ala Leu 330 Ala 75 Ile Asp Phe Leu Pro 155 Phe Ser Arg Asp Tyr 235 Tyr Phe Leu Ile Phe 315 Glu Leu Ser Arg Giu Lys 140 Leu Lys Phe Gly Cys 220 Val Phe Leu Ile Pro 300 Leu Tyr Ile Gin Thr Ile 125 Ser Ser Asp Thr Arg 205 Asp Asp Phe Asn Tyr 285 Tyr Giu Phe Ile Asp Ser 110 Asp Phe Tyr His Lys 190 Met Thr Lys Pro Ala 270 Tyr Tyr Ile Lys Asn Glu Phe Asn Ala Leu Tyr 175 Ser Asp Thr Tyr Met 255 Pro Gin Phe Lys Lys 335 Ala Pro Ile Asp I le Ile 160 Arg Asn Tyr Leu Pro 240 Arg Ser Tyr Gly Asp 320 Leu INFORMATION FOR SEQ ID NO:1622: SEQUENCE CHARACTERISTICS: LENGTH: 262 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM-: Helicobacter pyiori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .262 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1622 Asn Ilie Leu Lys Asn Cys Phe Lys Asp Thr Leu Val Ser Leu Ile Lys 1 S 10 Val Ser Gly Asp Lys Lys Val Ile Giu Val Ser Ile Pro Leu Thr Ser 25 Ile Ser Gly Lys Ala Arg Val Lys Ile Arg His Ala Phe Ser Asp Tyr 40 PGT/US 96/0912.2.
u' S i GEU'1996 1171 Gly Ile Ser Thr Ala Thr Arg Lys Ile Pro Phe Ser Leu Lys His Tyr 55 Val Glu Trp Gln Ile Gly Tyr Asp Val Pro Ile Lys Asp Lys Glu Lys 70 75 Phe Glu Leu Thr Thr Leu Lys Asp Glu Lys Tyr His Phe Leu Gly Ala 90 Asn Asn Lys Val Lys Thr Leu Tyr Glu Leu Ser Giu Met Ile Tyr Tyr 100 105 110 Ala Lys Arg Leu Gly Leu Ile Ser Leu Glu Asn Leu Glu Asn Thr Leu 115 120 125 Lys Phe Leu Giu Lys Gin Lys Gin Phe Ile Glu Asp Asn Phe Met Ile 130 135 140 Thr Arg Glu Arg Phe Arg Ser His Gln Phe Gly Gly Met Asp Phe Glu 145 150 155ss 160 Leu Leu Arg Ile Ser Tyr Pro Leu Leu Ile His Ser Phe Asp Asp Asn 165 170 175 Glu Leu Ser Glu Ile Val Ile Lys Glu Gln Gln Tyr Gly Ser Lys Thr 180 185 190 Gin Ala Met Leu Tyr Phe Cys Phe Ser Ile Leu Glu Leu Lys Thr Ala 195 200 205 Thr Pro Leu Leu Asn Arg Thr Ala Met Pro Lys Glu His Ala Leu Leu 210 215 220 Ile Ile His Glu Thr Asn Ala Leu Val Phe Leu Glu Met Leu Lys Ile 225 230 235 240 Phe Gly Leu Leu Ser Gin Val His His Asn Asp Val Leu Lys Ile Leu 245 250 255 Glu Lys Ile Leu Gln Asn 260 INFORMATION FOR SEQ ID NO:1623: SEQUENCE CHARACTERISTICS: LENGTH: 413 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...413 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1623 Leu Lys Ala Leu Asn Asp Cys Met Val Phe Phe His Lys Lys Ile lie 1 5 10 Leu Asn Phe Ile Tyr Ser Leu Met Val Ala Phe Leu Phe His Leu Set 25 Tyr Gly Val Leu Leu Lys Ala Asp Gly Met Ala Lys Lys Gin Thr Leu 40 Leu Val Gly Giu Arg Leu Val Trp Asp Lys Leu Thr Leu Leu Gly Phe 55 Leu Glu Lys Asn His Ile Pro Gln Lys Leu Tyr Tyr Asn Leu Ser Ser 70 75 Gin Asp Lys Glu Leu Ser Ala Glu Ile Gln Ser Asn Val Thr Tyr Tyr 90 Thr Leu Arg Asp Ala Asn Asn Thr Leu Ile Gin Ala Leu Ile Pro Ile 100 105 110 Ser Gln Asp Leu Gln Ile His Ile Tyr Lys Lys Gly Glu Asp Tyr Phe P1T9/U 9J6/0912_Z tS 10 6 1996 o E 6z 1172 Leu Leu 145 Asp Pro Arg Ala Asn 225 Leu Gly Asp Arg Ile 305 Ala Gly Gly Thr Lys 385 Ser Asp 130 Ser Pro Phe Asp Met 210 Gly Glu Arg Tyr Val 290 His Asn Arg Val Ala 370 Ala Phe Phe Leu Leu Lys Tyr 195 Val Arg Thr Phe Ala 275 Gly Leu Gly Val Tyr 355 Lys Gin Glu Ile Gin Leu Arg 180 Arg Ser Tyr Pro His 260 Ala Phe Asn Leu Gly 340 Lys Ser Tyr Lys Pro Thr Ala 165 Leu Val Ser Tyr Val 245 Pro Lys Ile Glu Lys 325 Ser Asn Lys Ser Asn 405 Ile Ser 150 Asn Val Gly Arg Asp 230 Lys Val His Gly Leu 310 Lys Thr Ser Leu Lys 390 Ser Val 135 Pro Gln Lys Gln Leu 215 Ser Tyr Leu Gly Val 295 Arg Gly Gly Arg His 375 Gin Phe 120 Phe Tyr Leu Asn Ala 200 His Lys Thr Lys Ser 280 Lys Leu Ser Leu Pro 360 Gly Lys Tyr Thr Gln Met Asp 185 Phe Gin Ala Arg Val 265 Leu Ala Val Phe Ser 345 Ile Lys Leu Leu Arg Asp Asn 170 Lys Gly Tyr Gin Ile 250 Lys Ile Gly Tyr Val 330 Thr Asn Gin Glu Leu 410 Lys Ile 155 Ala Ile Gin Tyr Glu 235 Ser Arg His Tyr Ala 315 Lys Gly Pro Arg Glu 395 Glu 125 Glu Arg 140 Val Lys Tyr Lys Ala Ile Pro Thr 205 Leu Phe 220 Val Ala Ser Pro Pro His Ser Ala 285 Gly Lys 300 His Met Lys Gly Pro' His Leu Gly 365 Glu Val 380 Leu Phe Gly Phe Thr Ala Lys Val 190 Ile Ser Gly Phe Tyr 270 Ser Val Ser Gin Leu 350 Tyr Phe Lys Leu Thr Ser 175 Tyr Lys His Phe Ser 255 Gly Asp Val Ala Ile 335 His Ile Leu Thr Leu Asn 160 Val Thr Met Ser Leu 240 Tyr Val Gly G1u Phe 320 Ile Ph9 Arg Glu His 400 INFORMATION FOR SEQ ID NO:1624: SEQUENCE CHARACTERISTICS: LENGTH: 253 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM; Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...253 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1624 Gly Cys Leu Met Lys Ser Ile Leu Leu Phe Met Ile Phe Val Val Cys 1 5 10 Gin Leu Glu Gly Lys Lys Phe Ser Gln Asp Asn Phe Lys Val Asp Tyr 25 Asn Tyr Tyr Leu Arg Lys Gln Asp Leu His Ile Ile Lys Thr Gln Asn 40 PCTIUS 961/09122Z IPENUS L 6 EG996 1173 Asp Leu Ser Asn Ala Trp Tyr Leu Pro Pro Gin Lys Ala Pro Lys Glu 55 His Ser Trp Val Asp Phe Ala Lys Lys Tyr Leu Asn Met Met Asp Tyr 70 75 Leu Gly Thr Tyr Phe Leu Pro Phe Tyr His Ser Phe Thr Pro Ile Phe 90 Gin Trp Tyr His Pro Asn Ile Asn Pro Tyr Gln Arg Asn Glu Phe Lys 100 105 110 Phe Gln lie Ser Phe Arg Val Pro Val Phe Arg His Ile Leu Trp Thr 115 120 125 Lys Gly Thr Leu Tyr Leu Ala Tyr Thr Gln Thr Asn Trp Phe Gin Ile 130 135 140 Tyr Asn Asp Pro Gin Ser Ala Pro Met Arg Met Ile Asn Phe Met Pro 145 150 155 160 G1u Leu Ile Tyr Val Tyr Pro Ile Asn Phe Lys Pro Phe Gly Gly Lys 165 170 175 Ile Gly Asn Phe Ser Glu Ile Trp Ile Gly Trp Gin His Ile Ser Asn 180 185 190 Gly Val Gly Gly Ala Gln Cys Tyr Gln Pro Phe Asn Lys Glu Gly Asn 195 200 205 Pro Glu Asn Gln Phe Pro Gly Gln Pro Val Ile Val Lys Asp Tyr Asn 210 215 220 Gly Gin Lys Asp Val Arg Trp Gly Gly Cys Arg Ser Val Ser Ala Gly 225 230 235 240 Asn Ala Leu Cys Phe Val Trp Cys Gly Lys Arg Glu Ala 245 250 INFORMATION FOR SEQ ID NO:1625: SEQUENCE CHARACTERISTICS: LENGTH: 83 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...83 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1625 Met Asn Arg Ala Trp Ile Lys Lys Lys Met Lys Lys Ile Lys Leu Thr 1 5" 10 Lys Arg Met Ile Ala Thr Ala Lys Lys Ala Leu Ser Lys Ser Tyr Gly 25 Tyr Cys Leu Val Gly Arg Phe Leu Ile Phe Phe Leu Arg Phe Cys Ile 40 Phe Phe Trp His Ala Gly Lys Lys Ser Tyr Cys Pro Ser Leu Ala Val 55 Lys Lys Thr Arg Lys Pro Gly Cys Arg Gly Ile Glu Ser Phe Tyr Gin 70 75 Pro Ser Lys INFORMATION FOR SEQ ID NO:1626: SEQUENCE CHARACTERISTICS: PCT/US 9 6 /0912 2 IPENUS 1 DEC 1996 1174 LENGTH: 93 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1...93 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1626 Arg Ile Glu Trp Gly Asn Arg His Cys Gly Ala Leu Ser His Ala Asn 1 5 10 Ser Val Ser Met Leu Leu Leu Phe Gly Ala Phe Leu Ser Ile Asn Leu 25 Gly Ile Leu Asn Leu Leu Pro Ile Pro Ala Leu Asp Gly Ala Gin Met 40 Leu Gly Val Val Phe Lys Asn Ile Phe His Ile Ala Leu Pro Thr Pro 55 Ile Gin Asn Ala Leu Trp Leu Val Gly Val Gly Phe Leu Val Phe Val 70 75 Met Phe Leu Gly Leu Phe Asn Asp Ile Thr Arg Leu*Leu INFORMATION FOR SEQ ID NO:1627: SEQUENCE CHARACTERISTICS: LENGTH: 424 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION 1...424 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1627 Asn Leu Gly Gly Ala Ala Asn Val Ala Asn Asn Leu Thr Ser Leu Lys 1 5 10 Ala Lys Val Phe Leu Cys Gly Val Val Gly Asp Asp Leu Lys Gly Lys 25 His Phe Ile Ser Thr Leu Asn Ser Ile Arg Ile Asp Thr Ser Gly Val 40 Leu Ile Asp Lys Thr Arg Cys Thr Thr Leu Lys Thr Arg Ile Ile Ala 55 Gin Asn Gin Gin Ile Val Arg Val Asp Lys Glu Ile Lys Asp Pro Leu 70 75 Asn Ala Asp Leu Arg Lys Asn Leu Leu Asp Phe Ile Ala Glu Lys Ile 90 Gin Glu Ile Asp Gly Val Ile Leu Ser Asp Tyr Asn Lys Gly Val Leu 100 105 110 ?CTUS96/0912.2 11275 Asp Phe Giu Leu Thr Gin Thr Ile Ile Thr Leu Ala 115 120 Lys His 145 His Leu Gin Ile Ala 225 Cys Ser His Asn Lys 305 Leu Asp Ser Ilie Asp 385 Arg Lys Leu 130 Ala Leu Gin Gly Ala 210 Ser Glu Ala Pro Gin 290 Gly Val1 Lys Leu Lys 370 Tyr Leu Ile Ilie Ser Lys Giu Ile 195 Lys Leu Phe Leu Lys 275 Gin His Val1 Arg Ser 355 Leu Leu Ile Lys Leu Leu Leu Thr 180 Ala Giu Thr Ala Ala 260 Ilie Lys Ala Gly Pro 340 Cys Ile As n Giu Arg 420 Cys Ile Asp 165 Tyr Phe Vai Leu Asn 245 Ser Leu Ile Ser Leu 325 Ile Vali Gin Lys Phe 405 Thr Asp Thr 150 Ser His Leu Tyr Ser 230 Ala Leu Pro Val1 Tyr 310 Asn Vai Asp Ala Giu 390 Giu His Pro Lys 135 Pro Asri His Ala Ile Ala Giu Lys 200 Asp Vai 215 Leu Leu Ala Ala Giu Giu Leu Giu 280 Phe Thr 295 Leu Gin Ser Asp Ser Giu Tyr Val 360 Leu Lys 375 Val Ile Giu Gly Asn Asp Gly Lys Arg Ala Asn Leu 170 Met Pro 185 Gly Giu Thr Gly Glu Ser Ala Val 250 Ile Ala 265 Lys Leu Asn Gly Lys Aia Asn Ser 330 Lys Asp 345 Val Vai Pro Asp Giy Ser Asp Glu 155 Ser Leu Leu Ala Lys 235 Vai Leu Leu Cys Lys 315 Ile Arg Phe Ile Glu Tyr 140 Leu Lys Val Vai Gly 220 Ser Val Ile Giu Phe 300 Ala
LYS
Ala Gly Leu 380 Leu Asn 125 Ser Giu Aia Thr Asn 205 Asp Leu Gly Leu Thr 285 Asp Leu Arg Phe G iu 365 Vai Ala Lys Lys Gin Leu Leu 190 Cys Thr Lys Lys Asn 270 Leu Ile Gly Leu Leu 350 Asp Lys Lys His Tyr Ala Gin 175 Ser Pro Val1 Giu Met 255 Gin Giu Leu Asp Lys 335 Leu Thr Giy Giu His Ser Leu 160 Ile Giu Thr Ile Ala 240 Gly Thr Arg His Ile 320 Giy Ala Pro Aia Thr 400 Tyr Ser Thr Ser Ala Ile 410 Ile Giu 415 INFORMATION FOR SEQ ID NO:1628: SEQUENCE CHARACTERISTICS: LENGTH: 321 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:. YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .321 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1628 Gly Ser Leu Met Val Asn Val Phe Phe Lys Gin Gin Lys Phe Val Ile 10 Lys Lys Arg Phe Asn Asp Phe Asn Gly Phe Asp Ile Glu Giu Asn Giu POT/UIS 0912Z2Z 1176 Val1 Leu Val Asn Met Gly Pro Val1 145 Thr Asp Leu Arg Leu 225 Ser Gin Pro Pro Ala 305 Leu Leu Ser Ser Ala Ala Thr Lys 130 Tyr Ser Asp Arg Ser 210 Thr Leu Asn Pro Giu 290 Ile Trp Gin Ser Phe Thr Leu 115 Lys Phe Leu Ile Asp 195 Asn Asp Asp Lys Thr 275 Leu Ser Phe Giu Val Phe Phe 100 Giu Phe Giu Leu Leu 180 Ser Lys Phe Asn Ile 260 Leu Giu Thr Giu Tyr Thr Thr Ile Ile Giu Lys Arg 165 Val1 Phe Val1 Ser Ile 245 Ile Ile Trp Ile Leu Ala Lys 70 Asn Leu Phe Asp Gly 150 Lys Arg Phe Asp Ser 230 Gin Lys Gly Gin Leu 310 Ile Ile 55 Tyr Gin Ser Asp Gly 135 Val1 Asn Leu Asp Ser 215 Leu Asn Leu Thr 295 Pro As n 40 His Trp Asp Asn Ser 120 Phe G iu Ile Ser Lys 200 Asp Val Leu Phe Ile 280 Gly Val1 25 Pro Giu Giu Asn 105 Ile Asp Cys Ile Asn 185 Arg Thr Giu Phe Thr 265 Tyr Tyr Ile Thr Asn Asp Asn 90 Ile Gin Ile Leu Phe 170 Leu Arg Lys Ser Ala 250 Val Gly Leu Tyr Pro Thr Ser 75 Glu Leu Lys Leu Glu 155 Lys Gin Ile Asn Thr 235 Ser Ala Met Phe Phe 315 Asn Giu Asp His Ser Ser Thr Phe Phe Thr Lys Val 125 Thr Lys 140 Trp Ile Giu Thr Giu Phe Ile Thr 205 Asn Leu 220 Thr Vai Gin Val Thr Met Asn Phe 285 Ala Leu 300* Lys Lys Leu Ser Val1 His Ile 110 Leu Ile Asn Ser Asn 190 Aia Asn Asn Asri Ala 270 Lys Ile Lys Ala Gin Thr Met Tyr Ala Phe Lys Thr 175 Val1 Leu Ile Leu Val1 255 Met Phe Val Gly Thr Arg Ile Giu Tyr Ser Giu Gin 160 His Ala Leu Ile Asn 240 Glu met Met Met Trp 320 INFORMATION FOR SEQ ID NO:1629: SEQUENCE CHARACTERISTICS: LENGTH: 244 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyiori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .244 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1629 Pro Phe Met Giu Phe Leu Ser Ser Leu Leu Asp Ala Leu Ser Thr Pro 10 His Gly Ilie Val Ser Leu Ala Thr Leu Thr Leu Leu Glu Ile Vai Leu 25 PCT/US 9 6/091 Z 1177 UQ US C 1996 1177 Gly Ile Asp Asn Ile Ile Phe Ile Thr Val Met Val Tyr Lys Leu Pro 40 Lys His Gln Gln Asn Lys Val Met Ile Leu Gly Leu Gly Leu Ala Met 55 Ile Thr Arg Ile Gly Leu Leu Gly Ser Leu Phe Phe Ile Ser His Leu 70 75 Gin Lys Pro Leu Phe Ala Ile Ala Gly Met Ser Phe Ser Trp Arg Asp 90 Val Val Leu Leu Leu Gly Gly Ala Phe Leu Ala Phe Lys Ala Leu Val 100 105 110 Glu Leu Lys Glu Gin Ile Tyr Pro Lys Glu Lys Arg Gin Glu Lys Ala 115 120 125 Phe Gly Phe Phe Ile Thr Leu Ile Giu Ile Met Phe Leu Asp Ile Val 130 135 140 Phe Ser Leu Asp Ser Val Ile Thr Ala Ile Gly Ile Ala Lys His Leu 145 150 155 160 Glu Val Met Ala Leu Ala Ile Ile Leu Ser Val Ile Val Met Met Phe 165 170 175 Phe Ser Lys Ile Val Gly Asp Phe Ile Glu Lys His Tyr Arg Val Lys 180 185 190 Thr Leu Ala Phe Val Phe Leu Leu Val Val Gly Val Phe Leu Phe Leu 195 200 205 Glu Gly Leu His Leu His Ile Asn Lys Asn Tyr Leu Tyr Ala Gly Ile 210 215 220 Gly Phe Ala Leu Leu Ile Glu Cys Leu Asn Ile Phe lie Glu Lys Lys 225 230 235 240 Met Lys Lys Ser INFORMATION FOR SEQ ID NO:1630: SEQUENCE CHARACTERISTICS: LENGTH: 156 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...156 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1630 Val Tyr Gly Phe Trp Ala Cys Val Leu Cys Gly Phe Lys Phe Gly Phe 1 5 10 Val Tyr Phe Ala Gin Thr Arg Ala Phe Gin Phe Arg Gin Asn His Ser 25 Phe His Arg Tyr Gin Asn Glu His Asp Phe Arg Pro Val His Ala His 40 Ser Arg Glu Phe Leu Arg Trp Gly Val Gly Glu Ile Leu Gly Ala Leu 55 Leu Gly Val Gly Pro Arg Asn Leu Gly Val Asp Phe Tyr Leu Arg Leu 70 75 Cys Leu Asp Leu Ala Phe Ala Phe Phe Arg Leu Ser Lys Leu Ala Leu 90 Tyr Phe Ser Glu Gln Gln Arg Ala Arg Val Leu Phe Gly Phe Asn Asp 100 105 110 Leu Phe Trp Arg Glu Leu Leu Pro Phe Trp Leu Ala Gin Leu Cys Arg A 1 F f 0 34 h 17 7f POTkJ., -0/091 2 2.
w i96 1178 115 120 125 Arg Ser Phe Ala Asp Pro Tyr Phe Phe Ile Leu Phe Gly Ser Asp Thr 130 135 140 Phe Arg Ser Arg Ile Leu Ala Tyr Phe Lys Arg His 145 150 155 INFORMATION FOR SEQ ID NO:1631: SEQUENCE CHARACTERISTICS: LENGTH: 162 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...162 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1631 Arg Tyr Ser Asp Gin Thr Asn Leu Leu Ala Leu Asn Ala Ala Ile Gli 1 5 10 Ala Ala Arg Ala Gly Glu His Gly Arg Gly Phe Ala Val Val Ala Asp 25 Glu Val Arg Asn Leu Ala Gly Arg Thr Gln Lys Ser Leu Ala Glu Ile 40 Asn Ser Thr Ile Met Val Ile Val Gln Glu Ile Asn Asp Val Ser Ser 55 Gin Met Asn Leu Asn Ser Gin Lys Met Glu Arg Leu Ser Asp Met Ser 70 75 Lys Ser Val Gln Glu Thr Tyr Glu Lys Met Ser Ser Asn Leu Ser Ser 90 Val Val Leu Asp Ser Asn Gin Ser Met Asp Asp Tyr Ala Lys Ser Gly 100 105 110 His Gin Ile Glu Ala Met Val Ser Asp Phe Ala Glu Val Glu Lys Val 115 120 125 Ala Ser Lys Thr Leu Ala Asp Ser Ser Asp Ile Leu Asn Ile Ala Thr 130 135 140 His Val Ser Gly Thr Thr Met Asn Leu Asp Lys Gln Val Asn Leu Phe 145 150 155 160 Lys Thr INFORMATION FOR SEQ ID NO:1632: SEQUENCE CHARACTERISTICS: LENGTH: 61 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori As tf:Anr:-) PCTUS 96 0912.
LJL 996 1179 (ix) FEATURE: NAME/KEY: misc-feature LOCATION .61 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1632 Ile Cys Leu Lys Leu Asn Gin Gly Gly Val Tyr Gin Lys Arg Val GJly 1 5 10 is Leu Leu Lys Val Ser Val Ile Thr Ala Cys Phe Asn Ser Giu Lys Thr 25 Ile Glu Asp Thr Ile Leu Ser Val Leu Asn Gin Thr Tyr Lys Asn Ile 40 Giu Tyr Ile Ile Ile Asp Gly Ala Ser Ala Ile Ala Leu 55 INFORMATION FOR SEQ ID NO:1633: SEQUENCE CHARACTERISTICS: LENGTH: 664 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .664 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1633 Asn His Ile Val Arg Gly Val Asp Cys Asp Arg Giy Val Ser Ile Leu 1 5 10 Gly Val Sen Leu Asn Ser Arg Val Lys Giu Ile Leu Lys Glu Ser Ala 25 Leu His Sen Met Gin Asp Ser Leu His Ph. Lys Val Lys Giu Val Gin 40 Ser Val Leu Giu Asn Thr Tyr Thr Ser Met Gly Ile Val Lys Giu Met s0 55 Leu Pro Giu Asp Thr Lys Arg Giu Ile Lys Ile Gin Leu Leu Lys Asn 70 75 Ph. Ile Leu Ala Asn Sen His Val Ala Gly Val Ser Met Phe Phe Lys 90 Asp Arg Glu Asp Leu Arg Leu Thr Leu Leu Arg Asp Asn Asp Thr Ile 100 105 110 Lys Leu Met Giu Asn Pro Sen Leu Gly Sen Asn Pro Leu Val Gin Lys 115 120 125 Ala Met Lys Asn Lys Giu Ile Ser Lys Ser Leu Pro Tyr Tyr Arg Lys 130 135 140 Met Pro Asn Gly Ala Giu Val Tyr Giy Val Asp Ile Leu Leu Pro Leu 145 150 155 160 Phe Lys Giu Asn Thr Gin Glu Val Val Gly Val Leu Met Ile Phe Phe 165 170 175 Sen Ile Asp Ser Phe Ser Asn Glu Ile Thr Lys Asn Arg Sen Asp Leu 180 185 190 Ph. Leu Ile Giy Val Lys Giy Lys Val Leu Leu Ser Ala Asn Lys Ser 195 200 205 Leu Gin Asp Lys Sen Ile Thr Glu Ile Tyr Lys Ser Val Pro Lys Ala 210 215 220 Thr Asn Giu Val Met Ala Ile Leu Giu Asn Gly Ser Lys Aia Thn Leu k IE E1 S U L U 1/9 2.2 ;i1>Us .LulE.U1996 1180 225 Giu Tyr I Thr Phe Met Ile 2 Ser Val 2 290 Leu Ile 305 Leu Giu I Asn Gin Asp Giu Thr Gin 370 Lys Val 385 Ala Glu Asp His Phe Lys Gin Asn 450 Glu Ile 465 Ala Asn Ala Ser Giu Asn Met Ile 530 Asp Ile 545 Ala Ala Giu Val Glu Ala Ser Ile 610 Glu Ala 625 Ser Leu Glu Asp eu Lys Ala 275 Arg Ile Val Ala Leu 355 Lys Val Pro Ala Ile 435 Ala Gln Asp Asn Ile 515 Giu Ala Arg Arg Asn 595 Lys Leu Glu Val Asp Met 260 Leu Phe Ala Val His 340 Gly Thr Ser Ala Leu 420 Phe Ser Lys Ser Ser 500 Thr Gin Asp Ala Lys 580 Ile Asn Arg Ile Asn 660 Pro 245 Leu Ile Val Ile Ser 325 Ser Arg Met Asp Ser 405 Phe Glu Gly Met Ala 485 Gin Thr Gly Gin Gly 565 Leu Asr Gin Se Se 64 Ly 230 Phe Gly Ile Val Thr 310 Ser Ser Met Gin Val 390 Pro Ala Ser Arg Leu 470 Asn His Ser Lys Thr 550 Giu Ala Ile Val Val 630 r Gln 5 s Lys 235 Ser His Lys Glu Asn 250 Lys Thr Glu Ser Lys 265 Giu Lys Asp Lys Val 280 Val Ala Ala Ser Ala 295 Leu Leu Met Arg Ala 315 Thr Leu Ser His Phe 330 Asp Ile Lys Leu Val 345 Gin Thr Ala Ile Asn 360 Glu Asp Trp Gin Ala 375 Lys Ala Gly Asn Phe 395 Asp Leu Lys Giu Leu 410 Arg Lys Arg Gly Thr 425 Tyr Ser Gly Leu Asp 440 Val Glu Leu Val Thr 455 Glu Thr Ser Ser Asn 475 Leu Lys Giu Cys Val 490 Lys Ser Leu Met Giu 505 Ile Gin Gly Val Ser 520 Asp Ile Lys Ser Ile 535 Asn Leu Leu Ala Leu 555 His Gly Arg Gly Phe 570 Giu Arg Thr Gin Lys 585 Leu Val Gin Ser Ile 600 Lys Glu Val Giu Glu 615 Thr Giu Gly Asn Leu 635 Giu Ile Asp Lys Val 650 Gin Phe ?he Asp Tyr Ile 300 Ile Phe Giu Lys Val 380 Ala Arg His Phe Asn 460 Phe Gin Thr Ser Val 540 Asn Ala Sex Ser Ii 62 Ly Leu Asn Glu 285 Met Val Lys Ala Asn 365 Gin Val Asp Met Arg 445 Ala Ala Asn Ser Gin .525 Giu Ala Val Leu Asp 605 e Asn 0 s Ile Ala Leu 270 Gln Val Ser Leu Arg 350 Ile Asp Arg Ala Pro 430 Gly Leu Lys Leu Lys 510 Ser Ile Ala Val Ser 590 Thr Ala Ala Val 255 Asn Val Leu Asn Leu 335 Ser Leu Thr Ile Leu 415 Ser Arg Gly Asp Giu 495 Thr Giu Ile Ile Ala 575 Glu Ser Ser Ser 240 Giu Trp Gly Ala Arg 320 Asn Asn Gin Ile Thr 400 Met Ile Ile Gia Leu 480 Lys Ile Ala Arg Glu 560 Asp Ile Glu Ile Asp 640 Ser Asn Asp Ile Leu 655 INFORMATION FOR SEQ ID NO:1634: SEQUENCE CHARACTERISTICS: LENGTH: 425 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein U.,LS jDEC 1996 (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .425 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1634 Arg Gly Giu Cys Tyr Phe Giu Arg Giu Ile Gly Leu Met Arg Lys Ile 1 5 10 Phe Sen Tyr Ile Ser Lys Val Leu Leu Phe Ile Gly Val Val Tyn Ala 25 Giu Pro Asp Ser Lys Val Giu Ala Leu Giu Gly Arg Lys Gin Giu Sen 40 Ser Leu Asp Lys Lys Ile Arg Gin Giu Leu Lys Ser Lys Giu Leu Lys 55 Asn Lys Giu Leu Lys Asn Lys Asp Leu Lys Asn Lys Giu Glu Lys Lys 70 75 Giu Thr Lys Ala Lys Arg Lys Pro Ang Ala Glu Val His His Gly Asp 90 Ala Lys Asn Pro Thr Pro Lys Ile Thr Pro Pro Lys Ile Lys Gly Ser 100 105 110 Ser Lys dly Val Gin Asn Gin Gly Val Gin Asn Asn Ala Pro Lys Pro 115 120 125 Giu Glu Lys Asp Thr Thr Pro Gin Ala Thr Giu Lys Asn Lys Giu Thr, 130 135 140 Sen Pro Sen Ser Gin Phe Asn Ser Ile Phe Gly Asn Pro Asn Asn Ala 145 iSO 155 160 Thr.Asn Asn Thr Leu Giu Asp Lys Val Val Gly Giy Ile Sen Leu Lou 165 170 175 Vai Asn Gly Sen Pro Ile Thr Leu Tyr Gin Ile Gin Giu Giu Gin Giu 180 185 190 Lys Sen Lys Val Ser Lys Ala Gin Ala Arg Asp Ang Leu Ile Ala Giu 195 200 205 Arg Ile Lys Asn Gin Giu Ile Giu Arg Leu Lys Ile His Val Asp Asp 210 215 220 Asp Lys Leu Asn Gin Glu Met Ala Met Met Ala Gin Gin Gin Giy Met 225 230 235 240 Asp Leu Asp His Phe Lys Gin Met Lou Met Ala Giu Gly His Tyn Lys 245 250 255 Leu Tyr Arg Asp Gin Lou Lys Giu His Leu Giu Met Gin Giu Leu Lou 260 265 270 Arg Asn Ile Leu Leu Thr Asn Val Asp Thn Sen Sen Glu Thn Lys Met 275 280 285 Ang Giu Tyr Tyr Asn Lys His Lys Giu Gin Phe Sen Ile Pro Thr diii 290 295 300 Ile Giu Thn Val Ang Tyn Thn Ser Thn Aen Gin Giu Asp Leu Giu Arg 305 310 315 320 Ala Met Ala Asp Pro Asn Leu Giu Val Pro Gly Val Sen Lys Ala Asn 325 330 335 diii Lys Ile Giu Met Lys Thn Lou Asn Pro Gin Ile Ala Gin Val Phe 340 345 350 Ile Ser His dlii Gin Gly Sen Phe Thr Pro Val Met Asn Gly Gly Gly 355 360 365 Giy Gin Phe Ile Thn Ph. Tyr Ile Lys Giu Lys Arg Gly Lys Asn Gu 370 375 380 Vai Ser Phe Sen Gin Ala Lys Gin Phe Ile Ala Gin Lys Leu Val Giu 385 390 395 400 Giu Ser Lys Asp Lys Ile Lou Glu Glu His Phe Glu Lys Leu Arg Val 405 410 415 Lys Ser 'Arg Ile Val Met Ile Ang Glu PGT/US, 9 091 262.
Itd I ±i DEC 1996 1182 425 420 INFORMATION FOR SEQ ID NO:1635: SEQUENCE CHARACTERISTICS: LENGTH: 336 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1...336 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1635 Ile Val Gln His Phe Asn Phe Leu Tyr 1 Ala Arg Ala Leu Ser Asn Ala Val Lys 145 Glu Ile Ala Ile Glu 225 Asp Asp Ile Ala Leu Ala Gln Lys Lys Arg Lys Lys 130 Leu Thr Lys Ala Ala 210 Ile Met Ile Phe Sex 290 Phe T 2 Tyr P Asn C His Ala I Pro Asn 115 Glu Leu Leu Asn Lys 195 Leu Asp Asn Ala Glu 275 Leu 5 hr P 0 he I ln I la I Asp Leu 100 Tyr Ile His Glu Tyr 180 Ile Asn Thr Ile Arg 260 Leu Thr he hr Asn Lys Val Lys Phe Leu Ala Cys 165 Leu Leou His Thr Pro 245 Sex Glu Ph Ile I Arg Ala Ile 70 Glu Asp Ser Arg Tyr' 150 Leu Tyr His Leu Giu 230 Ala Gin Val Glu s Arg 310 le .ys Tyr 55 Ser Met 3lu Val Phe 135 Glu Glu Leu Val Lys 215 Arg Phe Gly Le Ty 29 Ala L 2 Arg A 40 Ala S Ser I Ser Glu Gly 120 Ser Leu Glu Met Ser 200 Ser Leu Ile Leu i Arg 280 r Arg 5 eu 5 sn er eu Ile .ys L05 Tyr Pro Glu Leu His 185 Lys His Git Le Le 26 Al Cy Lys 10 Val Lys Ser Met Giu 90 Ile Leu Arg Lys Glu 170 Leu Ala Asp Asn I Glu 250 i Let 5 a Let s Ly
A
sp Ser Leu Phe Ser Ile Ile Leu I Lys Phe I Glu Asn I Phe Leu 75 Ile Leu Ala Val Gln Lys Asn Val 140 Asp Tyr 155 Val Pro Ile Glu Ser Leu Glu Asn 220 Val Ile 235 Lys His Asp His Leu His s His Cys 300 eu Leu Leu Ala Lys Leu Thr 125 G1u Ser Lys Asn Asp 205 Leu As; Ala Ly Se 28 Ly Glu G Gin L Asp G Arg A Gly L 9 Asp I 110 Lys I Ala Lys Ile Lys 190 Leu Phe Leu Leu 3 Pro 270 r Pro 5 s Gin 1n ys lu la eu Leu Asp Lieu Ala G1u 175 Glu Lys Trp Let Le 25 Cy Il
II.
Ala Phe Leu Tyr Leu Leu Thr Leu Leu 160 Thr Asp Lys Gin Trp 240 1 Gin s Gin e Lys e Phe Pro Phe Glu Ser Hi 305 Asp Met Val Leu Ly: Cys Pro Val Cys Gin Leu Ala Phe Met 320 Asp Ile Sen Lys Lys Thr 330 His Ala Met Gly PT/US 96/09122 NiuS oi DEC 1996 1183 INFORMATION FOR SEQ ID NO:1636: SEQUENCE CHARACTERISTICS: LENGTH: 255 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...255 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1636 Ile Arg Gly Ala Lys Thr Gly Gln Asn Asp His Leu Lys Gly 1 Met Pro Arg Asn Ile Leu Leu Glu Phe 145 Val Asp Thr Lys Lys Tyr Leu Asn Gly Ser Ala Glu 130 Glu Arg Leu Gin Gly Asn Leu Leu Glu Glu Lys Lys 115 Ile Ala Lys Glu Ala 195 Pro Lys Thr Glu Arg Leu Leu 100 Ala Ser Leu Ile His 180 Gin Asp 5 Arg Leu Gin Leu Leu Arg Ile Lys Met Ile 165 Leu Phe His Ser Glu Ala Glu 70 Tyr Ala Ala Gly Ala 150 Gin Phe Cys His Gin Lys Leu 55 Phe His Ser Leu Arg 135 Gly Asn Met Val Lys 215 Ala Asn Ala 40 Thr Leu Lys Ile Gin 120 Glu Val Leu Asp Ile 200 G1u Lys Ser 25 Leu His Gly Phe Val 105 Asp Lys Tyr Leu Tyr 185 Pro Phe Gly 10 Pro Gly Lys Asp Tyr 90 Ser Tyr Pro Leu Asn 170 Lys Thr Glu Lys Lys 250 Tyr Tyr Ser Ala 75 Gin Ala Leu Ser Glu 155 Arg Thr Tyr Met Ser 235 Val Ser Cys Val Tyr His Arg Ile 140 Ala Ala Ala *Gin Ala 220 Lys Thr Phe Lys Leu Asp Gly Val 125 Leu Gly Tyr Leu Leu 205 Leu Lys Pro Lys Leu Gly Glu Phe 110 Ser Ser Leu Lys Gin 190 Leu Tyr Glu Lys Met Asp Asn Asp Lys Ala Leu Leu Val Gly Lys Thr Lys Ser Ser Ser Ala Ala Lys 160 Arg Leu 175 Glu Leu Gin Glu Ile Gin Ala Glu 240 Lys 255 210 Asp Lys Met Tyr Ala Thr 225 230 Gin Gin Cys Ala Tyr 245 Gin Ala Leu Gin Leu Lys Glu Val INFORMATION FOR SEQ ID NO:1637: SEQUENCE CHARACTERISTICS: LENGTH: 143 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein PCTJUS 9 6 /0912 2.
thAMJS i DEC 1996 1184 (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_ feature LOCATION 1...143 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:163 7 Ala His Gin Ser Ser Arg Gly Val Ser Met Ile Leu Ala Cys Asp Val 1 5 10 Gly Leu Lys Arg Ile Gly Ile Ala Ala Leu Leu Asn Gly Val Ile Leu 25 Pro Leu Glu Ala Ile Leu Arg His Asn Arg Asn Gin Ala Ser Arg Asp 40 Leu Ser Asp Leu Leu Arg Lys Lys Asp Ile Gin Val Leu Val Val Gly 55 Lys Pro Asn Glu Ser Tyr Ala Asp Thr His Ala Arg Ile Glu His Phe 70 75 Ile Lys Leu Val Asp Phe Lys Gly Glu Ile Val Phe Ile Asn Giu Asp 90 Asn Ser Ser Val Glu Ala Tyr Glu Asn Leu Glu His Leu Gly Lys Lys 100 105 110 Asn Lys Arg Ile Ala Thr Lys Asp Gly Arg Leu Asp Ser Leu Ser Ala 115 120 125 Cys Arg Ile Leu Glu Arg Tyr Cys Gin Gin Val Leu'Lys Lys Gly 130 135 140 INFORMATION FOR SEQ ID N0:1638: SEQUENCE
CHARACTERISTICS:
LENGTH: 577 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...577 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1638 Lys Asn Glu Asn Phe Ile Lys Val Leu Ile Leu Asp Leu Lys Val Leu 1 5 10 Leu Gin Arg Ile Val Asp Phe Phe Ile Lys Leu Asn Lys Lys Gin Lys 25 Ile Ala Leu Ile Ala Ala Gly Val Leu Ile Thr Ala Leu Leu Val Phe 40 Leu Leu Leu Tyr Pro Phe Lys Glu Lys Asp Tyr Ala Gin Gly Gly Tyr 55 Gly Val Leu Phe Glu Arg Leu Asp Ser Ser Asp Asn Ala Leu Ile Leu 70 75 Gin His Leu Gin Gln Asn Gln Ile Pro Tyr Lys Val Leu Lys Asp Asp 90 Thr Ile Leu Val Pro Lys Asp Lys Val Tyr Glu Glu Arg Ile Thr Leu 100 105 110 PCT/US 96/0912.2 jPENUS 18DEC1996 1185 Ala Asp Ile 145 Pro Phe Lys Leu Val 225 Ser Asn Gly Gin Ser 305 Val Leu Thr Gly Lys 385 Ser Gly Phe Ile Lys 465 Ile Lys Leu Leu Giu 545 Leu Ser Thr 130 Arg Ile Val Pro Ile 210 Asn Lys Ile Lys Lys 290 Giu Gly Lys Asn Thr 370 Ile Asp Asp Asn Met 450 Tyr Val Giu Asn Asn 530 Lys Phe Gin 115 Lys Ala Leu Ala Asp 195 Ala.
Giu Glu Leu Asn 275 Lys Gin Gly Asp Tyr 355 Leu Ala Glu Asn Pro 435 His Ile Pro Val Lys 515 Ala Ile Lys Gly Asp Ile Lys Lys 180 Met Ala Asn Leu Glu 260 Lys Ser Asn Val Asn 340 Giu Met Leu Ser Gin 420 Met Lys Leu Phe Lys 500 Leu Ser Arg Leu Ile Phe Glu Ala 165 Glu Lys Ala Gly Ala 245 Asn Val Thr Leu Pro 325 Lys Val Arg Giu Leu 405 Asn Ala Thr Val Ser 485 Ser Gly Phe Gly Leu 565 Pro Gly Gly 150 Asn Val Leu Val Glu 230 Leu Lys Val Lys Glu 310 Gly Glu Gly Leu Asp 390 Lys Arg Pro Gin Phe 470 Glu Met Asp Ser Thr 550 Ile Lys Ala 135 Glu Val Pro Ser Pro 215 Ser Glu Ile Ala G1u 295 Glu Val Pro Lys Asn 375 Gly Lys Gly Met Lys 455 Ile Arg Phe Leu Glu 535 Leu Lys Thr 120 Thr Leu His Pro Pro 200 Lys Ile Gin Val Arg 280 Thr Lys Val Glu Thr 360 Ala Ala Ile Asp Ile 440 Ile Val Met Giu Arg 520 Glu Lys Asp ser Asp Ser Ile Ser 185 Thr Leu Gly Leu Asn 265 Val Phe Lys Ser Lys 345 Ile Ala Asn Asn Asp 425 Asp Leu Leu Leu Glu 505 Lys Glu Glu Glu Lys Phe Arg Ala 170 Ala Gin Thr Giu Arg 250 Ile Asn Asp Glu Asn 330 Tyr Ile Val Ala Ala 410 Val Asn Gly Phe Glu 490 Met Lys Val Arg Ile 570 Val Asp Thr 155 Ile Ser Ile Ile Gly 235 Tyr Leu Ala Pro Gly 315 Ile Glu Giu Val Leu 395 Leu Ala Ala Ser Ile 475 Val Asp Val Arg Pro 55S Ser Gly Gin 140 Ile Pro Val Leu Glu 220 Asp Lys Ala Glu Asn 300 Ala Gly Lys Ile Val 380 Glu Val Val Thr Phe 460 Phe Val Giu Glu Tyr 540 As; Ser Phe 125 Asn Glu Lys Met Gly 205 Asn Ile Gin Pro Phe 285 Asn Pro Pro Ser Lys 365 Asp Tyr Lys Ser Leu 445 Thr Tyr Pro Glu Asp 525 Glu Glu Asp Glu Ile Ser Asp Leu 190 Ile Ial Leu Asn Ile 270 Asp Ifa 1 Lys Val Gln 350 Gly Gly Glu Gin Asn 430 Ser Pro Lys Asp Glu 510 Gin Ile Ile Ser Ile Lys Leu Ser 175 Lys Lys Lys Glu Phe 255 Val Phe Val Lys Gin 335 Asn Glu Lys Pro Ala 415 Phe Glu Leu Lys Giu 495 Asp Leu Ile Ala Ala 575 Phe Leu Asn 160 Val Leu Asn Ile Asn 240 Glu Gly Ser Arg Gln 320 Gly Thr Phe Tyr Leu 400 Ile Glu Lys Ile Val 480 Asp Glu Gly Leu Thr 560 Lys INFORMATION FOR SEQ ID NO:1639: SEQUENCE CHARACTERISTICS:
-T
1186 LENGTH: 199 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...199 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1639 Lys Trp Cys Gly Tyr Cys Glu Arg Arg Ser Val Arg Arg Gly Tyr Tyr 1 5 10 Arg Ser Arg Lys Arg Leu Thr Lys Asn His His Ala Phe Ala Cys Ser 25 Leu Asp Phe Ile Tyr Pro Thr Asn Asn His Lys Val Ile Gln Glu Ile 40 Ala Gln Asn Gly Leu Ile Leu Ser Glu His Glu Lys Asp Phe Met Phe 55 Ile Lys Gly Phe Phe Leu Val Arg Asn Cys Leu Val Ile Ala Leu Thr 70 75 Asp Ala Val Ile Ile Pro Gin Ala Asp Leu Lys Ser Gly Ser Met Ser 90 Ser Val Arg Leu Ala Gln Lys Tyr Gln Lys Pro Leu Phe Val Leu Pro 100 105 110 Gin Arg Leu Asn Glu Ser Asp Gly Thr Asn Glu Leu Leu Glu Lys Gly 115 120 125 Gin Ala Gln Gly Ile Phe Asn Ile Gln Asn Phe Ile Asn Thr Leu Leu 130 135 140 Lys Asp Tyr His Leu Lys Glu Met Pro Glu Met Lys Asp Glu Phe Leu 145 150 155 160 Glu Tyr Cys Ala Lys Asn Pro Ser Tyr Glu Glu Ala Tyr Leu Lys Phe 165 170 175 Gly Asp Lys Leu Leu Glu Tyr Glu Leu Leu Gly Lys Ile Lys Arg Ile 180 185 190 Asn His Leu Val Val Leu Ala 195 INFORMATION FOR SEQ ID NO:1640: SEQUENCE CHARACTERISTICS: LENGTH: 276 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION 1...276 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1640 AM IZT POUS 96/0912Z2Z tubj~ ±u E G1996 1.187 Arg Asp Gly Ile Gin Asn Thr Thr Lys Ile 145 Leu Ala Val1 Giy Ser 225 Ala Leu Lys Leu Giu Giu Thr Ile Gin Arg Lys Pro 130 Ala Ser Asn Leu Gly 210 Ala G ly Asp Thr Lys Met Ala Leu Ser Met Asp Thr Thr Giu Ile Ser Gly Ala Ala Tyr Ile Asn Thr Leu GiY 100 Ser Leu Gin 115 Gin Gin Leu Leu Ile Leu Tyr Phe Pro 165 Leu Giy Giu 180 Giu Asn Lys 195 Leu Arg Ala Lys Thr Thr Ala Ile Lys 245 Asn Phe Ala Thr Ser Gly Lys Val 70 Thr Ser Thr Ala Ala 150 Asp Ile Leu Val Leu 230 Glu L~ys Glu Giu Gin 55 Leu G ly Giu Gin Asp 135 His Giu Ser Giu Ala 215 Ala Met Leu Lys Ile 40 Ile Giu Giy Giu Lys 120 Phe Met Met Pro Ser 200 Giu Arg Met Thr Ile 25 Leu Val1 Giu Leu Ala 105 Asn Ile Giu Lys Gin 185 Leu Ile Ile Phe Pro 10 Aia Arg Gin Phe Glu 90 Arg Phe Ile Ala Ala 170 Val1 Thr Phe Giu Thr Lys Ile His Leu Ph.
75 Tyr Lys Ala Asn Pro 155 Giu Val Ser Asn Ser 235 Phe Gin Leu Leu Asn Ala Ala Val Tyr Giu 140 Asn Ile Lys Tyr Arg 226 Val G iu Lys Leu Asp Giy Ile Arg Met Leu 125 His Ala Ser Arg Lys 205 Leu Asp Asp Ala Ile Ile Thr Phe Giu Asp 110 Giy Pro Ala Ile Val1 190 Ile Gly Asn Ile Gin Gin Asp Asp Gin Leu Lys Lys Gin Glu Arg 175 Ser Glu Gin Lys Ala 255 Leu Val1 Ser Lys Ser Leu Leu Ile Thr Thr 160 Met Thr Val Lys Leu 240 Lys Ile Met Arg 250 Asp Phe 265 Lys Ser Gly Gly Leu Lys 270 260 Gly Leu 275 INFORMATION FOR SEQ ID NO:1641: SEQUENCE CHARACTERISTICS: LENGTH: 194 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .194 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1641 Arg Ser Leu Gly Lys Gly Arg Pro Met Asn Lys Lys Asn Sen Val Ile 1 5 10 Sen Gly Leu Met Asn Ph. Phe Sen Giu Lys Asn Glu Arg Tnp Leu Leu 25 Ala His Ang His Thr Arg Gly Phe Val Ile Val Ala Trp LeU Phe Ang 40 Phe Lys Se Ile Aia Phe Ser Ile Leu Ile Thr Leu Leu Val Ile Leu PCT/US 9 6 /091 2.
PEA/US u-a uu 1996 Val Ser Val Phe Arg Ala 145 Asp Glu Gly Asp Ser Ile Ala Ser 130 Glu Ser Met Asp Ile Ser Val Leu 115 Asn Glu Asn Ile Trp Val Phe Ile 85 Ile Ser 100 Ile Gin Arg Lys Ile Ile Asp Glu 165 Leu Lys 180 55 Ser Leu Arg Lys Ala 135 Lys His Gin Asp Leu Lys Arg 120 Lys Lys Lys Glu Val Ile Cys 105 Gin Asn Gin Asp Glu 185 Arg Ala 90 Tyr Ile Phe Glu Lys 170 Leu 1188 Gin Phe 75 Leu Leu Gin Phe Arg Glu Glu Lys 140 Glu Ser 155 Leu Ser Lys Ala Leu Leu lie Lys Ser Gin 110 Asn Leu 125 Leu Ser His His Asn Ile Arg Lys 190 Asp Trp Lys Lys Asn Lys Thr 175 Asp Thr Gly Met Asn Ile Glu 160 Glu Lys INFORMATION FOR SEQ ID NO:1642: SEQUENCE CHARACTERISTICS: LENGTH: 539 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...539 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1642 Leu 1 Ser His Ile Thr Phe Ile Lys Met Leu Cys Asp Ser Leu Phe Thr Asp Gly Asn Pro Asp Asn Ser Ile 115 Arg Lys Tyr Gly Gly Arg Ser 100 Gin Ala Lys Phe Ile Phe 5 Gly Gin Thr Ala Asn Val Ile Ile Val Met Glu 70 Leu Ile Val Ser Ser Ser Ile 40 Ser Pro 55 Thr Asp Thr Arg G1u Asn Pro His 120 Gly Leu 135 Glu Gly Arg Asn Arg Ala Ser 25 Leu Leu Leu Leu Glu 105 Val Asp Met Lys Thr 185 lal 10 Ser Lys Glu Asp Asn 90 Arg Thr Phe rhr Ile Ile His Ile Asn Lys Asp Leu Gly Ala Asp Gly Gly Phe Gly Glu Ile 140 Gly Thr I Pro Glu His Thr Glu Ile 125 Val Glu Asn i Arg ral Leu ryr Val Tyr Thr Tyr 110 Lys Glu Prc Met Se: 191 Leu 15 Leu Ile Phe Glu Gly Leu Arg Val Ile t Hi! 17 r Ar 0 Ser Gin Asn Val Arg Gin Gly Arg Gly Arg 160 s Val g Pro Ile Lys Ser Ala Ala Lys 130 Gly 145 Gln Thr Thr Val Leu Lys Leu Met Gly Leu Pro 180 Asp Glu 165 Tyr Met 150 Leu Ile Phe Tyr Val 155 Ala Leu Ile 170 Ser Glu Let POUSz' 9 1'/O091 PENiUS 16 E 1996 1189 Thr Ile Lys 225 Thr Giy Pro Lys Glu 305 Leu Giu Phe Arg Ala 385 Ser Giu Ser Met Giu 465 Trp Ile Phe Leu Gin Ile 210 Ile Asp Ile Lys His 290 Ser Asp Lys Gly Leu 370 Ile Thr Asp Pro Pro 450 Arg Giu Giu His Asp 530 His 195 Leu Ala Thr Leu Met 275 Lys Tyr Thr Thr Glu 355 Glu Val1 Giu Phe Leu 435 Asn His Asn Ala Pro 515 Phe Ser Ala Leu Lys Thr 260 Ala Val Lys Gin Asp 340 Arg Lys Giu Phe Met 420 Giy S~pr Arg Lys Ile 500 Giu Ile Val1 Arg Ser Ser 245 Pro Aia Lys Ser Val1 325 Leu Gly Leu Phe Asn 405 Asp Gly Leu His Giy 485 Giu Phe Lys Glu Leu 200 Pro Lys 215 Asp Vai Tyr Ala Ala Arg Asn Thr 280 Gly Phe 295 Ile Giu Ile Giu Gly Val Giu Gly 360 Phe Leu 375 Arg Asn Arg Cys Asn His Met Arg 440 Giu Lys 455 Tyr Giu Lys Vai Giu Asp Ser Arg 520 Ala Leu 535 Arg Pro G iu Cys Arg 265 Leu Val1 Ala Trp Asp 345 Lys Giy Val Giu Gin 425 Leu Ala Ile Val His 505 Leu His Arg Leu Gin Pro 250 Phe Val Gly Leu Leu 330 Ala Ile Ile Leu Tyr 410 Lys Gly Tyr Asn Gly 490 Pro Gin Lys Leu Asp Asp 235 Ile Asn Glu Lys Ile 315 Asp Ile Cys Cys Gly 395 Pro Gin Glu Lys Pro 475 Phe Phe Ser Ser Gly Lys 220 Ser Leu Leu Lys Tyr 300 His Ser Leu Ala Leu 380 Leu Vali Val Tyr Lys 460 Lys Giy Phe Pro Val1 205 Giu Val Phe Asn Ile 285 Leu Ala Giu Val Ile 365 Giy Lys Val Arg Glu 445 Pro Tyr Ala Val Asa 525 Thr Pro Leu Lys Ile Vai Leu Gin 255 Lys Leu 270 Ile Ala Ser Leu Giy Ala Asn Phe 335 Pro Gly 350 Gin Arg Met Gin Gly Ala Tyr Leu 415 Thr Tyr 430 Cys Glu Asn Ile Arg Gin Asn His 495 Gly Val 510 Pro Ile Gin Lys Ala 240 Giu His Pro Lys His 320 Asn Gly Ala Leu Asn 400 Ile Asn, Ile Lys Glu 480 Lou Gin Ile INFORMATION FOR SEQ ID NO:i643: SEQUENCE CHARACTERISTICS: LENGTH: 369 amino acids TYPE: amino acid TOPOLOGYt linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .369 (xi) SEQUENCE DESCRIPTION: SEQ ID, NO:i643 POT/us, 9 6/ 091 R~ 2.
JPENJUS lb DEC 1996 1190 Ile Phe Glu Giu G1u Gin Leu Lys Ile Arg 145 Gly Asp Phe Ser Phe 225 Aia Lys Ile Giu Asn 305 Asp Thr Gin Leu Trp Ala Phe Ala Leu Lys Thr Giu Lys 130 Asp Asn Ser Asn Giu 210 Lys Leu Leui Giu Gly 290 Tyr Gly Met Asp Arg Arg Ser Ser Ser Thr Thr Val 115 Giu Lys Val1 Aia Ile 195 Asn Leu Leu Gin Ser 275 Giu Asn Lys Asn Asn 355 Gly Tyr His Leu Lys Giu Leu 100 Asn Val Arg Phe Asp 180 Ile Lys Thr Asn Asp 260 Thr Pro Ile Giu Asp 340 Asn Cys Thr Leu Phe Asn Ala Gin Ser Giu Asp Lys 165 Phe Asp Giy Asn Val1 245 Tyr Asn Val Lys Ile 325 Ile Thr Gly Lys Lys Thr Ala 70 Leu His Leu Asn Giu 150 Ser Asp Gly Giy Ile 230 Tyr Ile Ala Giu Asn 310 Ala Ile Glu Ser His Asp Ala Asn Tyr 25 Giu Ala Ser 40 Asp Leu Gin 55 Lys Asp Ser Thr His Asn Lys Ala Ser 105 Gly Ser Gin 120 Asn Lys Ser 135 Leu Giu Phe Ser Ile Lys Giu Ser Tyr 185 Ser Ile Phe 200 Leu Asn Gin 215 Thr Asp Lys Asn Asp Gly Asp Leu Leu -265 Ile Tyr Ala 280 Phe Asn Ser 295 Gly Ser Phe Arg Lys Thr Gin Val Ile 345 Asn Asp Phe 360 Arg Giu Aia Asp Ala Ile 90 Glu Ile Leu His Thr 170 Asn His Vai Leu Ser 250 Asp Gin Asp Asp Ile 330 Asn Val1 Asn Tyr Tyr Gin 75 Lys G iu Aia Lys Leu 155 His Leu Pro Asn 235 Asn Ser Ser Giu Leu 315 Ala Ala His Thr Phe Ph.
Lys Asp Leu Giu His 140 Arg Ser Asn Leu Phe 220 Gin Gly Phe Ala Aia 300 Ile Ile Asn Asp Tyr Pro Asn Gin Thr Lys Ile 125 Aia Giu Leu Ile Val1 205 Gin G ly Thr Aia Ser 285 Phe Aia Thr Thr Phe 365 Giu Tyr Asp Ser Ala Arg Ser 110 Asn Asn Leu Thr Gly 190 Vai Ser Lys Leu Arg 270 His Lys Tyr Pro Asp 350 His Phe Vai is Asp Thr Ile Asp Trp Lys Leu Ala Glu Arg Val Ile Lys Arg Giu Leu Leu Giy 160 Asp Lys 175 His Gly Lys Giu Asp Asp Val Giy 240 Lys Giy 255 Giy Leu His Ile Asp Thr Asn Thr 320 Ile Thr 335 Asp Asn Ser Giu Asp Glu Leu INFORMATION FOR SEQ ID NO:i644: SEQUENCE CHARACTERISTICS: LENGTH: 271 amino acids TYPE: amino acid TOPOLOGY: iinear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori PjJUS 9 091 1191 (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1...271 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1644 Lys Thr Lys Leu Val Phe Met Ile Lys Ala Arg Phe Lys Lys Arg Leu Lou Glu Thr Ile Leu Lou Lys Asn Arg 145 Lou Gin Leu Lou Phe 225 Cys Leu Gly Ala Ile so Giu Lys Phe Asp Leu 130 Val1 Asp Gin Vai Phe 210 Ser His Asn Ser Glu Lou Ala Pro Pro Lys 115 Ser Aia Glu Gly Ser 195 Lou Asn Tyr Pro Arg Val Arg Asn Gin His 100 Asn Gin Lou Pro Lou 180 His Asn Arg Glu Thr 260 Gly Val Ile His Gin Lou Lys Gin Ala Lou 165 Leu Asp Asn Leu Val 245 Phe Aia Ala Lou Ser 70 Arg Asn Ile Lys Arg 150 Asn Asp Pro Gly Lou 230 Ile Lys Phe Lou Ala 55 Vai Lys Vali His Ile 135 Ala Ala Phe Asn Val 215 Val Pro Lou Asp Lou 25 Lou Gly 40 Gly Lou Trp Leu Ile Gly Tyr Gin 105 Giu Vai 120 Pro Lys Lou Ile Lou Asp Ile Lys 185 Glu Ilie 200 Ile Asp Lys Pro Gin Thr Asp Phe 265 Asn Giu Glu Asp Phe 90 Asn Lou Lou Ala Asn 170 Arg Thr Pro Lou Ile 250 Ile Ile Ser Ala Thr 75 Val Ile Arg Sor Ala 155 Ala Giu Lys Asn Phe 235 Ser Gin Asp Lou Gly Ala Val Ser Gin Lys Phe Gin Ala Phe Lou Met 125 Gly Gly 140 Lys Asn Lou Lys Asn Lou Lou Ala 205 Gin Glu 220 Giu Asp Lou Pro Asn Lys Glu Giy Ser Lys Asp Ala 110 Arg Gin Lou Asn Sor 190 Arg Asn Glu Lys Lys 270 Ile Lys Giy Ile Tyr His Lou Ala Lou Giu 175 Val1 Thr Arg Asn Asp 255 Phe Lys Ser Tyr Phe Ala Pro Giu Gin Lou 16 0 Val Lou Phe Lou Tyr 240 Cys INFORMATION FOR SEQ ID NO:i645: SEQUENCE CHARACTERISTICS: LENGTH: 71 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:-YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .71 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1645 Gly Lou Sor Ala Thr Ile Lou Gly Met Trp Ile Met Sor Sen Lou Sor 10 1s Sor Sen Phe Phe His Ser Lou Pho Phe Ile Lys Sor Asn Pro Gly Gin 4 p--P POT/US 9 6 09122.
PEA/US 1 DEC1996 1192 Leu Val Arg 25 Leu Lys Gly Trp Gly Ser Lys Ile Phe Phe Ile Asn Arg Lys Phe 40 Leu Ala Gin Tyr Asn Pro Ser Val Ser Ile Phe Ile Leu Leu Asn 55 Val Phe Gly Val Gly Val INFORMATION FOR SEQ ID NO:1646: SEQUENCE CHARACTERISTICS: LENGTH: 75 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...75 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1646 Ile Gin Arg Ser His Gin Leu Phe Asn Leu Gin Glu Lys Lys Gly Ile 1 5 10 Leu Gly Phe Leu His Gin Lys Asn Ile Leu Asn Ile Ala Gin Asn Asp 25 Ile His Gin Leu Leu Ile Leu Met Val Val Phe Ser Met Leu Ala Thr 40 Pro Phe lie Leu Lys Tyr Leu Glu Ser Ile Ala Gin Phe Ile Leu His 55 Gin Lys Ser Gin Glu Asn Glu Pro Ala Lys Lys 70 INFORMATION FOR SEQ ID NO:1647: SEQUENCE CHARACTERISTICS: LENGTH: 117 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION 1...117 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1647 Gly Leu Met Arg Ile Ile Ile Arg Leu Leu Ser Phe Lys Met Asn Ala 1 5 10 Phe Leu Lys Leu Ala Leu Ala Ser Leu Met Gly Gly Leu Trp Tyr Ala 25 PCT/US 96/0912 2 IPEA/US 1 DEC1996" 1193 Phe Asn Gly Glu Gly Ser Glu Ile Val Ala Ile Gly Ile Phe Val Leu 40 lie Leu Phe Val Phe Phe Ile Arg Pro Val Ser Phe Gin Asp Pro Glu 55 Lys Arg Glu Glu Tyr Ile Glu Arg Leu Lys Lys Asn His Glu Arg Lys 70 75 Met Ile Leu Gin Asp Lys Gin Lys Glu Glu Gln Met Arg Leu Tyr Gin 90 Ala Lys Lys Glu Arg Glu Ser Arg Gin Lys Gln Asp Leu Lys Glu Gin 100 105 110 Met Lys Lys Tyr Ser 115 INFORMATION FOR SEQ ID NO:1648: SEQUENCE CHARACTERISTICS: LENGTH: 109 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE:
N
NAME/KEY: misc_feature LOCATION 1...109 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1648 Arg Lys Lys Met Glu Ile Ile Leu Leu Ile Val Ala Ala Val Val Leu 1 5 10 Phe Tyr Phe Tyr Asn Thr Leu Lys Glu Tyr Leu Lys Asn Pro Leu Asn 25 Pro Lys Thr Lys Thr Glu Glu Tyr Asp Leu Lys Asn Asp Pro Tyr Leu 40 Leu Val Gin Ser Ser Pro Leu Asp Lys Phe Lys Gln Thr Gin Ile Gly 55 Ala Tyr Met Arg Leu Leu Lys Phe Leu Asp Ile Gln Lys Asn Ala Leu 70 75 Asp Asn Ala Leu Arg Thr Leu Phe Ile His Glu Leu Glu Gln Pro Leu 90 Asn Ser Glu Gin Gln Asn Leu Gly Gin Arg Ala Ser Gin 100 105 INFORMATION FOR SEQ ID N0:1649: SEQUENCE CHARACTERISTICS: LENGTH: 543 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: *p v PCT/US c /0912 1/ 10 E C1996 1194 NAME/KEY: miscfeature LOCATION .543 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1649 Met Pro Asn Asn Ala Leu Leu Gin Ile 1 Ile Asp Gly Asn Cys Asp Ile Arg Leu Thr Leu Asn Lys Leu Phe Asn 130 Val Ser 145 Ser Leu Asn Leu Tyr Leu Tyr Tyr 210 Asn Lys 225 Gly Thr Thr Leu Leu Asn Giu Gly 290 Lys Met 305 Asn Glu Val Pro Leu Phe Ala Ile 370 Asn Lys 385 Ile Cys Ile Ile Asp Ala Thr Arg 450 Asn Lys 465 Asp Gly Lys Asp Leu Tyr Asp 115 Thr Gin Leu Gin Leu 195 Thr Pro Leu Tyr Leu 275 Asn Asp His Asn Phe 355 Ile Asn Met Phe Ser 435 Leu Ala Leu Tyr Phe Tyr Ser Leu 100 Ala Lys Tyr Asp Asn 180 Lys Pro Thr Leu Ala 260 Ile Thr Phe Ala Ile 340 Gin Val Val Pro Phe 420 Lys Arg Pro 5 Lys Lys Glu Lys Asp Phe Ile Ser Ile Lys 165 Gin Asp Leu Gin Met 245 Gin Leu Leu Ile Glu 325 Pro His Pro Arg Ser 405 Gin Leu Pro Lys Val Ile Phe Asp 70 Lys Glu Phe Thr Asn 150 Leu Gin Tyr Ser Ser 230 Ala Asp Asn Thr Val 310 Ile Lys Cys Thr His 390 Gin Lys Gly Ser Ser 470 Ile Ile Phe 55 Phe Lys Lys Asn Asp 135 Glu Lys Gly Asn Ile 215 Val Leu Ile Asp Asn 295 Ser Ser Asn Leu Gly 375 Leu Val Thr Giu Asp 455 Asp Cys Thr 40 Phe Asn Leu His Arg 120 Giu Gly Asn Tyr Asn 200 Ala Lys Ala Ser Leu 280 Pro Asn Gin Asp Asn 360 Phe Val Phe Pro Glu 440 Met Phe Lys 25 Gin Glu Glu Pro Phe 105 Ile Thr Ser Phe Asp 185 Asna Ser Ile His Gin 265 Thr Tyr Pro Asn Lys 345 Met Ile Asp Ala Ser 425 Tyr Asp Cys Lys 10 Asp Cys Gin Giu Lys 90 Tyr Ser Thr Lys Asn 170 Phe Ser Ile Tyr Gin 250 Lys His His Pro Lys 330 Ser Leu Ser Glu Asn 410 Ala Thr Leu Ala Ala Phe Lys Glu 75 Leu Asp Ser Ile Arg 155 Phe Phe Gly Ile Asp 235 Ile Ser Ser Ser Phe 315 Asn Lys Ser Ala Arg 395 Thr Lys Glu Ile Leu 475 Gly Leu Phe Lys Ala Asn Asn Ala 140 Ala Lys Ala Gly Ala 220 Pro Gly Leu Leu Lys 300 Lys Asp Met Pro Lys 380 Leu Gly Glu Asna Leu 460 Val Gin Asp Thr Leu Ser Leu Leu Tyr Pro Glu Tyr4 Asp Asn 125 Leu Asn Gin ,Pro Thr 205 Lys Ser Thr Arg Arg 285 Asp Leu Phe Pro Lys 365 Ser Val Thr Val Lys 445 Glu Ser Ala Lys Asn Tyr Asp Leu 110 Ala Phe Phe Ala Ile 190 Tyr Leu Ala Asp Met 270 His His Asp Phe Ile 350 Gly Gly Tyr Asn Ile 430 Asn Thr Phe is Gly Phe Lys Phe Glu His Glu Giu Thr Phe 175 Phe Ala Leu Gly Ser 255 Leu Ala Lys Phe Leu 335 Tyr Lys Val Gly Val 415 Leu Lys Phe Asp Asp Leu Thr Phe Leu Leu Leu Ser Arg 160 Leu Glu Glu Val Thr 240 Cys Lys Ile Gly Ser 320 Gly Thr Gly Asn Val 400 Ser Ile Lys Gin Giu 480 KDS''r POUS 96/091Z IPENUJS .tbUEC1996 Ile Giu Gin Leu Thr Asp Gin Gin 530 1195 Giu Lys Asn Tyr Ser Lou Asn Pro Giy Gin Tyr 485 490 Thr Ser Giu Thr Ile Ser Gin Ala Glu Phe Giu 500 505 Tyr Ser Ser Giu Leu Aia Ser Leu Phe Asp Giu 515 520 525 Gin Giu Ile Leu Giu Thr Lou Lys Giy Vai Arg 535 540 Phe Thr Ile 495 Asn Leu Met 510 Ser Gin Asn Phe Giu INFORMATION FOR SEQ ID NO:1650: SEQUENCE CHARACTERISTICS: LENGTH: 192 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Heiicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 192 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:i650 Lys Giy 1 Giu. Asn Val Gin Aia Aia Lys Ile Thr Lys Ile Gin Aia Lys Tyr Lou i3 0 Glu Giu 145 Sen Phe Arg Ile Phe Giu Phe Phe Arg Aia His 100 Gin Asn Ile Met Phe 180 5Met Lys Giu Gin Glu Trp Sen Giu Aia Aia Lys Lou Lou Lou Ala Asp 165 Lys Ala Asn Asn Met 70 Ph.
Lou Ala Ile Lou 150 Giu Arg Giu Aia Thn 55 Ala Tyr Ph.
Ph.
Giu 135 Ala His Arg Glu Tyr Leu Tyr Sen Phe Ile 120 Lys Lou Lou Ile Phe 25 Gin Lys Ala Gin Giu 105 Lys Lys Sen Ph.
Asn 185 10 Lou Asn His Gin Cys 90 Ile Lys Lys Pro Ser 170 Ph.
Asp Lys Asn Tyr Lou 75 Giu Glu Cys His Val 155 Lou Ser Lou Ser Ala Lou Phe Thr Lou Giu Lou Met Ph.
Lys Thr 140 Gly Asn Pro Lou Lys Asn Ph.
Ala Lys Asp 125 Lou Val Ile Lou Gin Asn Lou Ala Cys Asn 110 His Asn Gly Ser Ala 190 Thn Leu Ser Lys Ala Lou Ala Lou Ala Lou 175 Gin Giu Asp Glu Asn Asn Asp Ph.
Asp Ph.
160 His Pro INFORMATION FOR SEQ ID NO:1651: SEQUENCE CHARACTERISTICS: LENGTH: 155 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein PCT/US 9 6 /091 2 JPEA/US i DEC 1996 1196 (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...155 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1651 Ala Lys Glu Leu Leu Asn Glu Pro Val Asp Lys Lys Glu Asn Phe Glu 1 5 10 Ser Leu Cys Gin Glu Ile Ala Asp His Thr His Gly Glu Tyr Thr Lys 25 Arg Leu Lys Leu Val Glu Phe Leu Met Leu Leu Ala Tyr Ala Asp Gly 40 Ile Leu Asp Ser Lys Glu Lys Glu Leu Phe Leu Asp Val Gly Ala Phe 55 Leu Gin Ile Asp Asn Gin Asp Phe Asn Glu Leu Tyr Asp Asn Phe Glu 70 75 His Phe Asn Ser Ile Glu Ile Pro Met Ser Leu Glu Glu Ala Lys Asn 90 Leu Phe Glu Ile Gln Thr His Thr Thr Met Gin Asp Leu Glu Lys Lys 100 105 110 Ala Leu Asp Leu Ser Ala Pro Tyr Tyr His Lys Met Asn Asp Asn Lys 115 120 125 Arg Tyr Ser Glu Gin Asp Phe Ile Ser Leu Lys Lys'Ile Ala Leu Ala 130 135 140 Ser Gin Leu Leu Glu Asn Asp Leu Lys Asp Ser 145 150 155 INFORMATION FOR SEQ ID NO:1652: SEQUENCE CHARACTERISTICS: LENGTH: 405 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...405 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1652 Met Pro Phe Leu Lys Ala Leu Ala Ser Phe Asp Ala Pro Phe Leu Glu 1 5 10 Lys Giu Ile Ser Lys Arg Phe Arg Asp Asn Leu Val Phe Phe Lys Ser 25 Tyr His Pro Asn Leu Phe Asn Ala Leu Asn Thr Pro Phe Lys Asn Tyr 40 Gin Leu Leu Phe Glu Thr Asn His Leu Asn Leu Leu His Thr Pro Thr 55 Asn Ala Leu Ser Tyr Pro Lys His Gln Met Ile Glu Thr Ala Phe Asn 70 75 Met Ala Lys Asn Pro Leu Asn Asn Pro Arg Trp Ser Leu Asp Asn Asn 90
~HFFR
PCT/7 Q 109 12 IPEN/S 18!JEC 1996 1197 His Leu Ser Lou His Tyr Lou Lys Ser 105 Leu Thr Gin Thr 130 Gdy Val 145 Arg Ph.
Ile Ser Lys Leu Phe Leu 210 Pro Tyr 225 Tyr Tyr Lou dly Lys Thr Gly Pro 290 Lys Phe 305 His Gly Leu Lys Gly Ala Lou Met 370 Tyr Arg 385 Gly Phe Leu 115 Pro Leu His Cys Ph.
195 Lys Lys Lys Val1 Lys 275 Ser Ile Val Giu Asn 355 Phe Ile Asp Lys Cys Asp Ser Tyr 180 Ile Arg Ser Gin Lys 260 Pro Leu Ile Lys Val 340 Met Met Arg Glu Ala Thr Ser Lou Gly Lou 150 Lou Tyr 165 Phe Ala Gin Gly Pro Ile Ala Ph.
230 Ala Lou 245 Asn Thr Lys Lys Asp Lou Ph. Sor 310 Val Asp 325 Lou Giu Lou Asn Arg Gly Sor Ala 390 Arg 405 His Lys 135 Ph.
Leu Arg Ph.
Thr 215 Asn Arg Lou Ile Lou 295 Cys Ph.
Arg Pro Gly 375 Ph.
Ala 120 Lys Lou Ph.
Tyr Ph.
200 His Lou Giy Lys Asn 280 Lou Gly Gin Ala Asn 360 Ser Cys Ile Ph.
Ala Giu Giu 185 Asn Sor Arg Trp Asn 265 Aia Asp Thr Ile Pro 345 Ala Ala Gly Gin Ser Lou Ile Glu 170 Asp Pro Ph.
Met Gly 250 Leu Pro Ph.
Ala Giu 330 Leu Ph.
Cys Gin Asn Pro Lou 155 Asn Lou Asn Lou Arg 235 Ser Pro Ile Lou Lou 315 Val Giu Asp Ala Cys 395 Phe Pro 140 Gin Lou Ile Glu Lys 220 Giu Ph.
Lou Cys Lys 300 Lys Giu Asp Lou Tyr 380 Arg Asn Asn His Lou 125 Thr Ala Asp Lys Lou 205 Lou Asn Giu Cys Val1 285 Giu Pro Arg Thr Ala 365 Lys Gly Lys 110 Asp Moet Gin Lou Lys 190 Lys Giu Ile Asp Gin 270 Val1 Asn Lou Ile Pro 350 Lys Pro Gly Lou Pro Asn Ile Asn Phe 175 Gly Met Ile Gin Giu 255 Thr Gly Glu Lys Asp 335 Lou Giu Ph.
Ph.
His Tyr Tyr 160 Lys Ala Asp Met Ser 240 Lou Lou Asn Giu Ala 3 Tyr, Met Ala Giu Ser 400 INFORMATION FOR SEQ ID N0:1653: SEQUENCE CHARACTERISTICS: LENGTH: 413 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:-YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .413 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1653 Lys Gly Lou Gly Lou Ser Glu Trp Gi1n Thr Ph. Cys Lou Lys Asp Lou 1 5 10 is Gly Lys Ile Val Gly Gly Ala Thr Pro Pro Thr Asn Asn Pro Lys Asn f 77nSHEE PCT/' 9 6 /0912 2 IPEA/US 18 DEC 1996 1198 Thr Tyr Gin Phe I Ser Cys Phe Asn Gly 145 Ile Lys Tyr Thr Pro 225 Ser Gly Val Asp Leu 305 Gin Lys Asn Leu lie 385 Gly ;ly Lys Ser rhr Glu Ile 130 Leu Ala Ile Phe Ser 210 Asn Gly Tyr Thr Ile 290 Gin Ser Lys Glu Leu 370 Lys Asn Arg Ser Arg Asn Phe 115 Gly Phe His Asn Val 195 Gly Asp Ser Ile Tyr 275 Met Gly Met Tyr Asn 355 Gin Asn Lys Ile Ala Trp Ile Pro ryr Cys Ala Gln 100 Leu Gly Gln Thr Glu 180 Arg Gly Phe Gin Arg 260 Ile Met Ala Gin Leu 340 His Lys Asn Ile Lys Lys 55 Ser Cys Val 70 Pro Ile Gly Gly Phe Lys Tyr Tyr Leu Gly Thr Thr 135 Val Lys Ile 150 Leu Ser Ile 165 Leu Leu His Phe Asp Phe Lys Met Lys 215 Lys Val Lys 230 Pro Pro Lys 245 Phe Ile Gin Pro Ile Ser Asp Lys Tyr 295 Tyr Asn Val 310 Glu Tyr Ile 325 Ser Asn Ala lile Tyr Ser Tyr Glu Lys 375 Gin Ser Thr 40 Gly Ser Arg Leu Leu Pro Tyr Val Ala 90 Ser Ile Ile 105 Leu Lys Tyr 120 Phe Lys Glu Pro Pro Thr Leu Asp Gin 170 Lys Ile Leu 185 Leu Asp Glu 200 Phe Ser Lys Thr Leu Gly Ser Cys His 250 Asn Arg Asp 265 Lys Asn Asn 280 Gly Glu Ala Ala Leu Ser Arg Ser Tyr 330 Cys Met Ala 345 Leu Met Leu 360 Ile Ala Lys Gin Thr Leu Lys Ser Lys 75 Ile Pro Tyr Val Tyr 155 Lys Glu Asn Glu Glu 235 Ile Tyr Lys Gly Lys 315 Leu Ser Pro Asp Ile His Ala Asn Lys Ser 140 Tyr Ile Leu Asn Leu 220 Leu Tyr Ser Ile Ser 300 Ile Asn Thr Ile Leu Ser Ala Glu Lys Asp 125 Gly Glu Glu Leu Lys 205 Asn Ile Glu Ser Cys 285 Val Ser Ser Arg Pro 3er Arg Ile Lys Lys 110 Asn Ala Gln Asn Tyr 190 Pro Arg Thr Tyr Asn 270 Tyr Arg Val Lys Ala 350 Pro Thr I Leu Leu Arg Ile Ile Thr Gin Asn 175 Glu Tyr Leu Trp Lys 255 Asn Gin Phe Leu Pro 335 Ser Ile Leu Gly Phe Leu Tyr Ser Leu Lys 160 His Gln Gin Ile Ile 240 Glu Tyr Tyr Gly Asn 320 Ile Leu Asn 365 Asn Ile Ile Thr Ala Ile 380 Thr Ala Leu Arg Asp Phe 395 400 Lys Pro Gin Leu Leu Pro Leu Leu Leu 405 Lys Gln Gin Val 410 INFORMATION FOR SEQ ID NO:1654: SEQUENCE CHARACTERISTICS: LENGTH: 197 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori Atvr-ln SHEET 96/091ZZ IPEA/US UDE ;996 1199 (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...197 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:16 54 Gly Val Thr Leu Ile Gin Gln Glu Gly Phe Ile Met Ile Lys Arg Ile 1 5 10 Ala Cys lie Leu Ser Leu Ser Ala Ser Leu Ala Leu Ala Gly Glu Val 25 Asn Gly Phe Phe Met Gly Ala Gly Tyr Gin Gin Gly Arg Tyr Gly Pro 40 Tyr Asn Ser Asn Tyr Ser Asp Trp Arg His Gly Asn Asp Leu Tyr Gly 55 Leu Asn Phe Lys Leu Gly Phe Val Gly Phe Ala Asn Lys Trp Phe Gly 70 75 Ala Arg Val Tyr Gly Phe Leu Asp Trp Phe Asn Thr Ser Gly Thr Glu 90 His Thr Lys Thr Asn Leu Leu Thr Tyr Gly Gly Gly Gly Asp Leu Ile 100 105 110 Val Asn Leu Ile Pro Ser Asp Lys Phe Ala Leu Gly Leu Ile Gly Gly 115 120 125 Val Gln Leu Ala Gly Asn Thr Trp Met Phe Pro Tyr Asp Val Asn Gin 130 135 140 Thr Arg Phe Gin Phe Leu Trp Asn Leu Gly Gly Arg Met Arg Val Gly 145 150 155 160 Asp Arg Ser Ala Phe Glu Ala Gly Val Lys Phe Pro Met Val Asn Gin 165 170 175 Gly Ser Lys Asp Val Gly Leu Ile Arg Tyr Tyr Ser Trp Tyr Val Asp 180 185 190 Tyr Val Phe Thr Phe 195 INFORMATION FOR SEQ ID NO:1655: SEQUENCE
CHARACTERISTICS:
LENGTH: 366 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc.feature LOCATION 1...366 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1655 Phe Arg Phe Tyr Phe Phe Lys Ala Asn Arg Ser Tyr Trp Gly Lys Val 1 5 10 Phe Met Val Asn Ser Thr Leu Tyr Ile Val Ile Ala Gly Leu Trp Leu 25 Ala Val Gly Phe Gly Ile Phe Leu Lys Lys Leu Asp Met Pro Val Ile 40 Ile Gly Tyr Ile Cys Thr Gly Thr Val Leu Ala Ala Phe Phe Lys Ile 55 Asn Asp Phe Asn Leu Leu Ser Asp Ile Gly Glu Phe Gly Ile Val Phe 70 75 Leu Met Phe Met Ile Gly Ile Glu Phe Asn Phe Asp Lys Leu Lys Ser
A~?D~DSHEET,
POUS 9 6/ 0912Z2Z IPE.NIS 18 DEC 1]96 1200 Ile Lys Gin Giu Val Leu Val Phe Ala Ilie Ile 145 Gly Pro Asn Leu Ala 225 Ilie Ser Lys Ala Met 305 Phe Lys Ser Leu Phe 130 Val Lys Met Leu Leu 210 Lys Vali Leu Ile Leu 290 Giu Lys Thr Phe Ile 115 Ser Leu Ser Leu Leu 195 Leu Asp Cys Gly Asn 275 Phe Lys Thr Ala Val1 355 100 Ala Leu Lys Ala Leu 180 Ile Leu Thr Ser Aia 260 Val1 Phe Phe Phe Ile 340 Ile Phe Val1 Phe Val1 165 Ile Leu Pro Arg Aia 245 Phe Gin Ile Phe Ile 325 Lys Phe Leu Leu Phe 150 Gly Leu Lys Glu Leu 230 Ala Ile Giu Thr Val1 310 Ile Thr Leu Leu G ly 135 Giu Ile Thr Thr Lys 215 Pro dly Val1 Giu Ile 295 Val1 Tyr Ala Asn Gly 120 Met Asp Leu Ile Leu 200 Lys C iu Leu Giy Phe 280 Giy Ilie Ala Leu Ser 360 Gly 105 Tyr Gly Ser Ile Leu 185 Ile Gly Ile Ser Met 265 Ala Met Phe Leu Ser 345 Ala Phe Leu Lys Phe 170 Gly Ser Ala Phe His 250 Ala Gin Gin Leu Leu 330 Leu Leu Val1 Ser Gin Gin Ser Ala Asn Ile 235 Phe Ile Leu Ile Leu 315 Arg Ala Ala Leu Leu Gin Leu Leu 140 Leu Asp Lys Gly Leu 220 G iy Phe Ser Lys Asn Ile Phe Gin Pro Val Giy 125 Ser Ser Ile Asp Ile 205 Ile Thr G ly Lys Asn 285 Val Leu Phe Ile Ala 365 Val1 110 Leu Ser Thr Ala Ser 190 Ile Leu Val Phe Ser 270 Leu Ser Val Arg Gly 350 Leu Leu Ser Thr Pro Ala 175 His Leu Giu Leu Ser 255 Arg Phe Phe Met Asp 335 Glu Cys Pro Ala Met 160 Ile Val Ile Gin Val 240 Met Leu Phe Ser 320 Ala Phe INFORMATION FOR SEQ ID NO:1656: SEQUENCE CHARACTERISTICS: LENGTH: 242 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION I1.. .242 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1656 Cys Leu Cys Val Gly Gly Ala Leu Ala His Ile Ser Pro Leu Ser Ile 1 5 10 is Giu Tyr Ala Ala Pro Phe Val Gly Asn Ala Gly Val Ala Leu Ala Gly 25 Leu Met Sen Asp Giu Ile Tyr Leu Cys Ala Leu Asp Cys Ala Tyr Ile 40 Lys Gly Phe Lys Lys His Ala Gin Asn Ser Tyr Tyr Gly Asp Giu Lys 55 PCT/US 9 6 091 22 IPEA/US iD£G 996 1201 Glu Ile Asp Thr Ser Ser Leu Ile Ser Val Glu Gly Asn Val GIu Gly 70 75 Tyr Glu Thr Phe Ser Asp Ser Leu Phe Leu Leu Ser Lys Glu Arg Ile 90 Glu Glu Ala Leu His Tyr Tyr Gln Pro Lys Lys Val Tyr Asn Leu Ser 100 105 110 Tyr Gly Ala Lys Ile Lys His Ala Val Ser Leu Asn His Ser Gln Val 115 120 125 Lys Leu Lys Gln Ile Asn Lys Gin Asp Ala Ile Val Arg Ile Lys Ser 130 135 140 Met Phe Ser Pro Arg Ser Asn His Ala Lys Asp Leu Lys Asn Leu Gin 145 150 155. 160 Lys Asn Leu Ile Arg Phe Lys Glu Asp Phe Phe Thr His Leu Asn Thr 165 170 175 Pro Cys Lys Thr Lys Gln Glu Ala Phe Glu Trp Val Asp Ser Leu Ser 180 185 190 Gly Phe Cys Gln Thr Ala Ser Ala Lys Thr Pro Thr Ile Gly Ile Leu 195 200 205 Phe Glu Gly Ser Val Ala His Ile Leu Gln Ser Val Leu Ile Val Ser 210 215 220 Leu His Leu Lys Glu Asn Glu Leu Thr Leu Leu Ser Asn Ser Leu Lys 225 230 235 240 Thr Pro INFORMATION FOR SEQ ID NO:1657: SEQUENCE CHARACTERISTICS: LENGTH: 319 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...319 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1657 Ile Leu Leu Val Glu Leu Lys Leu His Pro Lys Ile Gly Tyr Phe Ser 1 5 10 Lys Arg Phe Asn Phe Leu Ser Lys Met Arg Val Leu Glu Trp Lys Tyr 25 Trp Leu Asn Thr Asp Lys Trp Asp Thr Pro Thr Asn Lys Pro Pro Gin 40 Thr Phe Lys Ile Gln Ile Phe Lys Ile Gln Ile Gly Ile Ile Asn Asn 55 Phe Asn His Leu Ile Lys Gly Ser Ser Met Lys Asn Ala Phe Lys Ala 70 75 Phe Ala Leu Leu Ile Val Phe Phe Ser Asn Ala Leu Leu Ala Gln Asp 90 Leu Lys Ile Ala Ala Ala Ala Asn Leu Thr Arg Ala Leu Lys Ala Leu 100 105 110 Val Lys Glu Phe Gln Lys Glu His Pro Lys Asp Ala Ile Asn Ile Ser 115 120 125 Phe Asn Ser Ser Gly Lys Leu Tyr Ala Gln Ile Ala Gln Asn Ala Pro 130 135 140 Phe Asp Leu Phe Ile Ser Ala Asp Ile Ala Arg Pro Lys Lys Leu Tyr 1 POUS 96IO0912Z IFENUS
E.~
1202 145 Asp Leu Lys Pro Pro 225 His Ser Lys Gly Pro 305 Giu Val1 Asp Tyr 210 Ser Gin Leu Thr Ala 290 Lys Lys Leu Pro 195 Gly Leu Phe Ile Leu 275 Asn Ala Ile Trp 180 Lys Lys Lys Ile Asp 260 Tyr Asn Arg 150 Pro Giu Lys Ser Lys 230 Thr Lys Pro Leu Ile 310 Glu 170 Met Met Leu Gly Gin 250 Leu Ala Phe Tyr 155 Val1 Asp Ala Asp Ala 235 Ile Ser Leu Lys Gly 315 INFORMATION FOR SEQ ID NO:1658: SEQUENCE CHARACTERISTICS: LENGTH: 228 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .228 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:i658 Lys Arg Arg Thr Met Asp His Giu Phe Leu Ile Thr Met Arg Leu Sen 1 Phe Phe Thr Gly Phe Leu Ile Tyr Pro 145 His Sen Leu Glu Phe Leu Ile Lys Ser 130 As n Thr Leu Gly Thn Tyr Gin Leu Ser 115 Leu Ile Ile 5 Ala Leu Tyr Phe Leu Val Leu Leu Asp Val Gly Sen 100 Ala Leu Gly Lys Lys Pro Gly Giu 165 Ile Leu Tyr Leu 70 Leu Val1 Ile Gly Sen 150 Phe Thr Ser Met 55 Ile Asn Ile Sen Glu 135 Val1 Gly Thr Leu 40 Pro Phe Val Phe Leu 120 Tyr Leu Val1 Leu 25 Lys Leu Ser Lys Ser 105 Pro Tyr Met Val1 10 I le Arg Val1 Pro Leu 90 Leu Thr Thn Ala Met 170 Leu Asn Leu Sen 75 Val1 Pro Ser Leu Ile 155 Met Leu Leu Pro Sen Phe Phe Leu Phe 140 Ile Leu Pro Ile Leu Thr Pro Ser Phe Leu Sen Phe Met Val Lys Glu 125 Phe Val Thr Thn Gly Gly Gly Ser Vai Gly Gin Ser Ala Leu Phe Asp 175 Ile Leu Leu Ala Gly Pro Sen Leu Met 160 Ile PCT/US 96/0912 2 IPEA/US -louwb 1203 Leu Gly Glu Thr Arg Val Ala Ser Ile Thr Ile Phe Asn Glu Ala Glu 180 185 190 Ala Leu Asn Tyr Ser Lys Ala His Gln Tyr Ala Leu Thr Leu Thr Leu 195 200 205 Ile Ser Phe Ser Leu Leu Phe Val Thr Leu Phe Leu Asn Lys Lys Gin 210 215 220 Ser Ser Phe Leu 225 INFORMATION FOR SEQ ID NO:1659: SEQUENCE CHARACTERISTICS: LENGTH: 187 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...187 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1659 Asn Phe Ile Phe Gly Glu Phe Ile Met Lys Arg Ser Ser Val Phe Ser 1 5 10 Phe Leu Val Ala Phe Leu Leu Val Val Gly Cys Ser His Lys Met Asp 25 Asn Lys Thr Val Ala Gly Asp Val Ser Thr Lys Ala Val Gln Thr Ala 40 Pro Val Thr Thr Glu Pro Ala Pro Glu Lys Glu Glu Pro Lys Gln Glu 55 Pro Ala Pro Val Val GIu Glu Lys Pro Ala Ile Glu Ser Gly Thr Ile 70 75 Ile Ala Ser Ile Tyr Phe Asp Phe Asp Lys Tyr Glu Ile Lys GIu Ser 90 Asp Gln Glu Thr Leu Asp GIu Ile Val Gln Lys Ala Lys Glu Asn His 100 105 110 Met Gln Val Leu Leu Glu Gly Asn Thr Asp Glu Phe Gly Ser Ser Glu 115 120 125 Tyr Asn Gln Ala Leu Gly Val Lys Arg Thr Leu Ser Val Lys Asn Ala 130 135 140 Leu Val Ile Lys Gly Val Glu Lys Asp Met Ile Lys Thr Ile Ser Phe 145 150 155 160 Gly Glu Ser Lys Pro Lys Cys Val Gin Lys Thr Arg Glu Cys Tyr Arg 165 170 175 Glu Asn Arg Arg Val Asp Val Lys Leu Val Lys 180 185 INFORMATION FOR SEQ ID NO:1660: SEQUENCE CHARACTERISTICS: LENGTH: 201 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein J~P POT/US 9 6 /09122 1204 (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...201 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1660 Lys Arg Ile Lys Arg Gly Phe Phe Met Gln Glu Ala Leu Leu Arg Phe 1 5 10 Gin Glu Gly Phe Lys Giu Trp Gly Tyr Leu Ile Leu Phe Leu Tyr Ser 25 Leu Gly Gly Gly Tyr Val Gly Ile Val Ile Ala Ser Ile Leu Ser Ala 40 Thr Thr His Ala Leu Asp Ile Lys Ile Thr Ile Leu Val Ala Phe Leu 55 Gly Asn Leu Ile Gly Ser Gly Ala Leu Val Ile Phe Ala Arg Tyr Gin 70 75 Lys Arg Glu Phe Leu Lys Tyr Phe Gln Lys His Arg Arg Lys Leu Ala 90 Leu Ala Ser Leu Trp Val Lys Arg Tyr Ala Leu Leu Met Ile Phe Val 100 105 110 Asn Lys Tyr Leu Tyr Gly Ile Lys Ser Val Val Pro Leu Ala Ile Gly 115 120 125 Phe Ser Lys Tyr Pro Leu Lys Lys Phe Leu Trp Leu Asn Val Phe Ser 130 135 140 Ser Phe Leu Trp Ala Leu Ile Val Gly Ser Val Ser Phe Gln Ala Ser 145 150 155 160 Asp Trp Val Lys Thr Leu Tyr Glu Arg Leu Ser His Tyr Thr Ser Phe 165 170 175 Phe Val Ile Ser Phe Val Leu Ile Ala Leu Leu lie Trp Phe Leu Leu 180 185 190 Lys Arg Tyr Ser Arg Lys Met Gly Phe 195 200 INFORMATION FOR SEQ ID NO:1661: SEQUENCE CHARACTERISTICS: LENGTH: 394 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...394 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1661 Ala Ser Phe Asn Tyr Asn Phe Gln Met Leu Arg Lys Asn Ile Leu Ala 1 5 10 Tyr Tyr Gly Ala Asn Phe Leu Leu Ile Ile Ala Gln Ser Leu Pro His 25 Ala Ile Leu Thr Pro Leu Leu Leu Ser Lys Gly Leu Ser Leu Ser Glu 40 PCT/US 96/091 2 2 iPEMs tjS DE 1996 1205 Ile Tyr Leu Phe Tyr Ile Gin 145 Leu Ile Gly Lys Leu 225 Met Phe Leu Val Phe 305 Tyr Ser Leu Thr Phe 385 Leu Pro Val Asp Ser Lys 130 Ile Tyr Met Asp Gly 210 Val Trp Val Lys Leu 290 Ile Cys Ser Ile Ile 370 Leu Leu Ser Ser Ser Ala 115 Glu Thr Leu Leu Phe 195 Ser Gly Gin Phe Ala 275 Leu Gly Leu Leu Leu 355 Ile Tyr Val Gly Asn Phe 100 Cys Asn Tyr Lys Cys 180 Lys Leu His Ala Tyr 260 Lys Gly Val Gly Ser 340 Ser Thr Lys Gin Val Val Ile Ser Lys Leu Val 165 Ala Ser Lys Leu Tyr 245 Ile Asn Val Tyr Tyr 325 Ser Leu Met Ala Thr Leu 70 Phe Leu Ser Lys Gly 150 His Leu Gin Glu Ile 230 Phe Ala Tyr Ser Ala 310 Gin Leu Ser His Lys 390 Phe 55 Ala Leu Met Gly Asp 135 Met Ala Thr Lys Leu 215 Thr Leu Phe Ser Pro 295 Leu Phe Leu Ser Phe 375 Pro Cys Ser 75 Phe Trp Ala Phe Ser 155 Val Tyr Leu Pro Phe 235 Val Ser Ala Ser Phe 315 Val Val Arg Leu Val Arg Ser Gly Ser Leu 140 Ser Val Phe Leu Lys 220 Met Lys Ile Leu Asn 300 Phe Ser Arg Tyr Ile 380 Leu Lys Phe Leu Leu 125 Ala Leu Gly Lys Lys 205 Leu Ser Glu Leu Ser 285 Ile Ala Lys Val Phe 365 Ile Val Asn Val Tyr 110 Ile Lys Gly Ile Glu 190 Glu Lys His Gin Ile 270 Ser Pro Tyr Asn Val 350 Ser Leu Ala Leu Leu Gly Thr Asn Ser Phe 175 Lys Gin Ile Phe Tyr 255 His Leu "ryr Met Asn 335 Ser Pro Phe Glu Phe Phe Leu Asp Asn Phe 160 Leu Glu Val Leu Gin 240 Leu Phe Leu Cys Ser 320 *Ile Val Leu Phe INFORMATION FOR SEQ ID NO:1662: SEQUENCE CHARACTERISTICS: LENGTH: 87 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...87 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1662 PCT/US 96/091 22 1206 Arg Arg Asn Leu Thr Arg Gln His Gly Ser Val Lys Lys Arg Glu Lys 1 5 10 Arg Phe Lys Thr His Ala Ser Leu Cys Asp Ser Val Arg Ser Gly Lys 25 Arg Leu Gly Tyr Thr Asn Gln Val Ile Thr Asp Ile Val Asn Ile Gly 40 Ile Gly Gly Ser Asp Leu Gly Ala Leu Met Val Cys Thr Ala Leu Lys 55 Arg Tyr Gly His Pro Arg Leu Glu Met His Phe Val Ser Asn Val Asp 70 75 Gly Thr Gln Ile Leu Asp Val INFORMATION FOR SEQ ID NO:1663: SEQUENCE CHARACTERISTICS: LENGTH: 74 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...74 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1663 Gin His Tyr Pro Asn Asn Leu Lys Asp Ile Glu Met Asn Thr Glu Ile 1 5 10 Leu Thr Ile Met Leu Val Val Ser Val Leu Met Gly Leu Val Gly Leu 25 Ile Ala Phe Leu Trp Gly Val Lys Ser Gly Gln Phe Asp Asp Glu Lys 40 Arg Met Leu Glu Ser Val Leu Tyr Asp Ser Ala Ser Asp Leu Asn Glu 55 Ala Ile Leu Gln Glu Lys Arg Gln Lys Asn INFORMATION FOR SEQ ID NO:1664: SEQUENCE CHARACTERISTICS: LENGTH: 242 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc feature LOCATION 1...242 krfiE,7D *i PC/US 9 6 0912 2 PEA/US 18 DEC1996 1207 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1664 Glu Met Gln Phe Leu His Ala His Leu Leu Ser Val Val Ile Phe Phe 1 5 10 Pro Met Leu Ser Ala Leu Leu Ala Phe Phe Met Ser Asp Gln Ala Ser 25 Arg Ala Tyr Ala Ile Val Ile Ala Leu Ile Glu Leu Leu Leu Val Leu 40 Leu Leu Trp His Gly Phe Asp Ile Gln Thr Ala Gly Met Gln Phe Glu 55 Glu Met Lys Glu Leu Ala Tyr Gln Ile Gly Val Asn Tyr His Val Gly 70 75 Val Asp Gly Ile Ala Leu Phe Leu Leu Leu Leu Asn Ala Ile Val Val 90 Leu Leu Ser Val Ile Tyr Val Lys Glu Arg Arg Lys Asp Phe Val Ile 100 105 110 Cys Leu Leu Leu Leu Glu Gly Ile Leu Met Gly Val Phe Ser Ser Leu 115 120 125 Asn Val Ile Phe Phe Tyr Ala Phe Trp Glu Ile Ser Leu Leu Pro Val 130 135 140 Leu Tyr Leu Ile Gly Arg Phe Gly Arg Asn Asn Lys Ile Tyr Ser Gly 145 150 155 160 Met Lys Phe Phe Leu Tyr Thr Phe Leu Ala Ser Leu Cys Met Leu Leu 165 170 175 Gly Ile Leu Tyr Ile Gly Tyr Asp Tyr Ala Asn Asn Tyr Gly Met Met 180 185 190 Ser Phe Asp Ile Leu Asp Trp Tyr Gln Leu Asn Phe Ser Ser Gly Ile 195 200 205 Lys Thr Trp Leu Phe Val Ala Phe Leu Ile Gly Ile Ala Val Lys Ile 210 215 220 Pro Leu Phe Pro Phe Thr His Gly Cys Leu Met Arg Ile Leu Whr Pro 225 230 235 240 Pro Leu INFORMATION FOR SEQ ID NO:1665: SEQUENCE CHARACTERISTICS: LENGTH: 496 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...496 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1665 Lys Arg Ser Leu Met Leu Ile Asp Ile Leu His Ile Ser Phe Asp Ser 1 5 10 Phe Ser Phe Glu Ser Ile Leu Pro Met Leu Val Leu Val Cys Gly Gly 25 Ile Phe Thr Leu Leu Ile Asn Ala Phe Thr Ser Arg Phe Ser Arg Asn 40 Leu Asn Val Phe Leu Cys Met Leu Phe Leu Val Leu Asp Phe Leu Val 55 Val Ser Gly Leu Glu Glu Gln Glu Asn Ala Phe Phe Gly Phe Leu Ser 11 I
I
A M E D S H E ZT PCT/US 9 6 /0912 2 IPEA/US 13 E 996 1208 Leu Phe Gin Gin Glu 145 Arg Ala Gly Ile Ala 225 Asp Val Phe Ile Asp 305 Ala Phe Leu Asp Val 385 Pro Glu Val Lys Asn 465 Cys Asp Phe Thr Phe 130 Thr Tyr Ser Ser Thr 210 Ile Val Pro Ile Leu 290 Val Leu Val Leu His 370 Ala Phe Ser Ala Pro 450 Ala Leu Thr Leu Ala 115 Met Ala Gly Ala Leu 195 Asn Gly Tyr Lys Asp 275 Met Lys Ala Tyr Trp 355 Pro Ile Ser Asn Ala 435 Leu Thr Phe Leu Ile 100 Glu Val Pro Leu Phe 180 Asn Pro Phe Glu Ile 260 Thr Thr Arg Cys Trp 340 Leu Tyr Leu Val His 420 Phe Gin Met Ser Ser Phe Phe Ser Leu Glu 165 Phe Leu Met Lys Gly 245 Ala His Ile Met Val 325 Phe Leu Ser Gly Phe 405 Ile Tyr Thr Pro Val 485 70 Leu Leu Tyr Ser Pro 150 Ala Ala Glu Leu Val 230 Asn Gly Thr Thr Leu 310 Phe Met Lys Lys Ala 390 Trp Leu Tyr Gin Ile 470 Phe Ile Ala Ser Asn 135 Leu Gly Met Val Phe 215 Ser Asn Phe Ala Ile 295 Ala Ile Phe Ser Phe 375 Ile Gly Leu Phe Ser 455 Tyr Met Ser Leu Leu 120 Gin Cys Ile Gly Ile 200 Ala Leu Pro Val Trp 280 Pro Tyr His Ala Arg 360 Asn Phe Lys Ala Arg 440 Tyr Ala Gin Ser 105 Tyr Phe Val Lys Ala 185 Thr Met Val Val Val 265 Val Asn Ser Thr Phe 345 Glu Gly Val Phe Val 425 Trp Ala Val Ser 90 Lys Leu Val Leu Tyr 170 Met Leu Gly Pro Phe 250 Ala Glu Phe Ser Glu 330 Thr Lys Leu Phe Leu 410 Val Leu Gin Ile 75 Ile Val Leu lie Glu Arg Phe Asn 110 Phe Ile Val Ala 125 Val Ile Leu Ile 140 Met Ala Leu Ser 155 Phe Thr Met Gly Ala Phe Tyr Leu 190 Tyr Leu His Thr 205 Thr Ile Phe Leu 220 Phe His Thr Trp 235 Ala Ser Tyr Ile Thr Arg Leu Phe 270 Asp Ile Phe Tyr 285 Ile Ala Leu Trp 300 Ile Ser His Ser 315 Asp Ser Gln Gin Tyr Ile Gly Ala 350 Thr Trp Asp Glu 365 Ile Lys Thr His 380 Gly Leu Ala Gly 395 Ala Val Glu Ser Met Leu Val Asn 430 Val Ala Met Phe 445 Asn Asp Ile Tyr 460 Ile Ala Met Ala 475 Leu Leu Glu Phe Ser Glu Gly Gly Asp Ala 175 Leu Glu Ile Met Ser 255 Gly Val Gin Gly Ala 335 Phe Arg Pro Ile Ala 415 Ser Phe Thr Leu Ala Phe Phe Leu Lys 160 Met Thr Gly Gly Pro 240 Ile Ala Leu Glu Phe 320 Met Gly Tyr Leu Pro 400 Leu Ala Asn Gin Ala 480 Met Arg Gly 490 Val Ala 495 INFORMATION FOR SEQ ID NO:1666: SEQUENCE CHARACTERISTICS: LENGTH: 296 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES PUI/us %0 91 I PEN4US 2u1 1209 (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .296 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1666 Asn Pro Ala Leu Ser Leu His Thr Trp Leu Pro Tyr 1 Ala Gly Ser Ilie Ile Phe Ala Glu Lys 145 As n Leu Thr Val1 Giu 225 Leu Giu Leu Asn Pro Thr G lu Tyr Ala Sen His Giu 130 Ser Val1 Leu Ser Phe 210 Asp Ile Gin Phe Arg 290 Thr Tyr Ile Gly Tyr Phe Gly 115 Ang Ala Giy Gly Ile 195 Phe Leu Leu Gly Leu 275 Tyr Leu Ala Tyr Gly Ser As n 100 Val Ala Pro Met Phe 180 Ile Gly Asn Ile Phe 260 Gly Ser 5 Gly Leu Leu Phe Ser Val1 Ile Ser Val1 Pro 165 Phe Leu As n Ala Leu 245 Lys Ser Pro Sen Leu Thr Leu 70 Phe Giu Val1 Sen Phe 150 Leu Ala Ser Leu Arg 230 Gly Gin Leu His Val Arg Pro 55 Ala Ser 0 ly Met Leu 135 Ala Ser Thr Ala Lys 215 G iu Ile Leu Asp Leu 295 Met Phe 40 Ile Tyr His Val1 Gly 120 Glu Ala Ile Tyr Val1 200 Thr Va 1 Tyr Leu Thr 280 Phe Leu 25 Leu Ala Ala Met Ser 105 Leu Ile Phe Gly Pro 185 Tyr 0 ly Gly Pro 0 iu 265 Lys 10 Ser Ala Leu Pro Ile Val Gin Lys 75 Gly Val 90 Gly Ala Phe Leu Ala Arg Phe Met 155 Phe Val 170 Leu Leu Met Leu Asn Asn Val Leu 235 Lys Ala 250 Val Ile Leu Leu Ala Asp Val1 Val1 Leu Phe 140 Ile Gly Ala Thr Gin 220 Ser Leu G lu Ala Leu Phe Leu Leu Val1 Phe Ala 125 Gly Val1 Glu Ile Sen 205 Ile Val1 Leu Ile Val1 285 Tyr Ser Pro Cys Lys Leu Met 110 Gly Ser Leu Phe Ile 190 Tyr Ser Ile Lys Arg 270 Ser Asn Lys Met Giu Leu Met Ile Thr Leu Gly Val Met Phe Ile Leu Ile Ala Met Ala 160 Leu Ser "17 Ala Gly Lys Asp Val Phe Leu Ala 240 Pro Ile 255 Ser Leu Ile Lys Glu Ser Tyr Val INFORMATION FOR SEQ ID NO:1667: SEQUENCE CHARACTERISTICS: LENGTH: 468 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: PCT/US 9 6 /0912 IPEA/US 18 DEC 1996 1210 NAME/KEY: misc_feature LOCATION 1...468 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1667 Ile Tyr Ser Lys Thr Arg Ser His Asp Met Asp Ile 1 Glu Ala Lys Phe Asp Glu His Pro Ala 145 Ala Lys Ala Ser Pro 225 Asn Ala Leu Gly Gly 305 Leu Phe Leu Asn Ile 385 Glu Ile Ile Lys Tyr Phe Ser Glu Leu Ile Asn Phe 130 Lys Leu Asn Leu Leu 210 Ser Ala Met Phe Glu 290 Lys Lys Phe Arg Thr 370 Ala Ala Ser Arg Asp Asp Ser Val Val Gly Asp Pro 115 Tyr His Glu Leu Gly 195 Tyr Glu Ile Leu Ala 275 Val Thr Glu Lys Ala 355 Ile Val Leu Ile Ala 435 Glu Ile Ile Phe Leu Leu Asn 100 Lys Gly Glu Ala Lys 180 Leu Ser Ala Leu Ser 260 Lys Lys Leu Thr Glu 340 Leu Lys Ser Lys Asp 420 Ser Thr 5 Arg Gly Val Ser Ile Ile Glu Lys Ile Tyr 165 Tyr Glu Asp Lys Ile 245 Ser Arg Cys Met Asn 325 Arg Glu Asn Glu Asn 405 Gly Asn Gly Val Gly Ala 70 Pro Gin Tyr Asp Lys 150 His Lys Pro Pro Asn 230 Gly His Leu Ser Tyr 310 Ala Tyr Leu Leu Glu 390 Pro Val Thr Ile Glu His 55 Gly Thr Cys Asn Ile 135 Pro Arg Ile Ile Asp 215 Leu Phe His His Gin 295 Lys His Phe Leu Pro 375 Glu Pro Arg Thr Tyr Leu 40 Asp Leu Pro Pro Gly 120 Gin Leu Tyr Ala Leu 200 Gly Lys Ala Ile Ala 280 Val Thr Phe Gly Leu 360 Tyr Lys Ser Val Pro 440 Pro 25 Gly Ala Gin Val Asn 105 Phe Ala Lys Leu Leu 185 Lys Asp Asp Phe Tyr 265 Gin Met Gly Ala Tyr 345 Glu Ser Phe His Val 425 Tyr 10 Thr Lys Arg Ser Ala 90 Ser Lys Leu Glu Ile 170 Asp Ala Phe Leu Asp 250 Ala Gly Tyr His Ala 330 Asp Gin Tyr G1u Phe 410 Phe Leu Thr Ile Val Ser 75 Tyr Ile Ile Lys Thr 155 Lys Phe Leu Pro Glu 235 Gly Gly Ile Asn Ser 315 Glu Asp Ser Thr Ile 395 Pro Glu Val Leu Met His Gly Phe Met Thr Asn 140 Pro Asp Gly Asn Asn 220 Lys Asp Asp Thr Ala 300 Asn Met Ala Pro Thr 380 Ile Thr His Ser Ser Asp Arg Gly Leu Ala Ile Leu 125 Thr Glu Phe Asn Ile 205 His His Ala Glu Pro 285 Ile Leu Ser Leu Ser 365 Pro Arg Ile Gly Arg 445 Ile Phe Glu Asn Glu Tyr Arg Phe Lys Val Ala Phe Thr Gly 110 Asn Gin Leu Leu Lys Val Lys His 175 Gly Val 190 Asp Phe w His Pro Met Arg Asp Arg 255 Leu Ala 270 Phe Val Asn Thr Lys Ile Gly His 335 Tyr Ala 350 Asp Leu Glu Glu Asn Leu Lys Glu 415 Phe Gly 430 Phe Glu Arg Thr Asp Leu Tyr Asn Ser Asn Asn Asn 160 Leu Gly Ser Asp Glu 240 lie Ile Ile Phe Lys 320 Ile Cys Glu Lys Gin 400 Ile Leu Gly Thr Ala Leu Glu Tyr Lys Arg Ala Leu Leu Gly Leu 455 460 450 Leu Glu Lys Leu 465 S-i 7
'T
PCT/US 9 /n091 2 IPEA/US 18 DEC1996 1211 INFORMATION FOR SEQ ID NO:1668: SEQUENCE CHARACTERISTICS: LENGTH: 214 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...214 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1668 Gly Ile Phe Met Asn Glu Ile Ile Leu Ile Thr Gly Ala Tyr Gly Met 1 5 10 Val Gly Gln Asn Thr Ala Leu Tyr Phe Lys Lys Asn Lys Pro Asp Val 25 Thr Leu Leu Thr Pro Lys Lys Ser Glu Leu Tyr Leu Leu Asp Lys Asp 40 Asn Val Gln Ala Tyr Leu Lys Glu Tyr Lys Pro Thr Gly Ile Ile His 55 Cys Ala Gly Arg Val Gly Gly Ile Val Ala Asn Met Asn Asp beu Ser 70 75 Thr Tyr Met Val Glu Asn Leu Leu Met Gly Leu Tyr Leu Phe Ser Ser 90 Ala Leu Asp Leu Gly Val Lys Lys Ala Ile Asn Leu Ala Ser Ser Cys 100 105 110 Ala Tyr Pro Lys Tyr Ala Pro Asn Pro Leu Lys Glu Ser Asp Leu Leu 115 120 125 Asn Gly Ser Leu Glu Pro Thr Asn Glu Gly Tyr Ala Leu Ala Lys Leu 130 135 140 Ser Val Met Lys Tyr Cys Glu Tyr Val Ser Ala Glu Lys Gly Val Phe 145 150 155 160 Tyr Lys Thr Leu Val Pro Cys Asn Leu Tyr Gly Glu Phe Asp Lys Phe 165 170 175 Glu Glu Lys Ile Ala His Met Ile Pro Gly Leu Ile Ala Arg Met His 180 185 190 Thr Ala Lys Leu Lys Asn Glu Lys Asn Phe Ala Met Trp Gly Asp Gly 195 200 205 Thr Ala Glu Glu Ser Ile 210 INFORMATION FOR SEQ ID NO:1669: SEQUENCE CHARACTERISTICS: LENGTH: 405 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori A~ti^ PCT/US 9 6/0912 HPANUS 1 A 1212 (ix) FEATURE: NAME/KEY: misc -feature LOCATION .405 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1669 Al a His Ala Asfl Arg Thr Ilie Ile His Arg Ile 1 Gin Ala Lys Asp Ser Leu Gin Leu Ala 145 Trp Phe Phe Val1 Val1 225 His Phe Giu Giu Lys 305 Lys Ala Val1 Lys Ser 385 Ile Arg Pro Ile Ser Val1 Lys As n Gin 130 Leu Asp Val1 Trp Leu 210 Gin Asp Asp Ala Ile 290 Giu Arg Leu Phe Leu 370 Ser Ile Val Leu Leu Giu Leu Thr Tyr 115 Val1 Leu Gly Gly Leu 195 Giu Lys Lys Ile Giu 275 Ala Phe Ile Ile Cys 355 Gin Ilie *Lys Asp Tyr Ala Thr Giu Tyr 100 Thr Gin Gin Ser Asp 180 Leu Ile His Lys Val1 260 Ser Phe Tyr Ala Ala 340 Asn Arg Pro Lys 5 Asn Leu Leu Ser As n Asp Thr His Asp Gly 165 Leu Giy Ala Phe Ile 245 Ala Gly Tyr Gin Lys 325 Pro Gin Giu Val1 Ala Thr Gly Val1 70 G iu Phe Thr His Pro 150 Ala Giu Gly Leu Lys 230 Gin Phe Gin Pro Ala 310 Lys Phe Leu Tyr Ile Leu Ala 55 Leu Lys Lys Lys His 135 His Tyr Arg Gin Lys 215 Giu Ser Ser Val1 Phe 295 Phe Phe Lys Leu Phe 375 Arg Pro Glu Leu His Pro M4et 120 Ala Leu Glu Ile Lys 200 His Asp Val1 Leu Leu 280 Glu Glu Phe Giy Cys 360 Phe Pro 25 L~ys Gln Leu Phe rhr 105 Ala His As n Asn Giu 185 Ala Gin G lu Ala Gly 265 Glu Ile Lys Asn His 345 Glu His 10 Met Arg Lys Ser Lys 90 Leu Phe Phe His Lys 170 G iu Ile Leu Leu Thr 250 Val1 Asn Lys Asp Ser 330 Val1 *Gin *Lys Arg Ser Gly Pro 75 G iu Leu Asp Leu Pro 155 Ile Val1 Lys Asn Gly 235 Asn Val Leu As n Leu 315 Leu Val1 Leu His Asp Leu Phe His Phe Thr Ala Phe Ala 140 Phe Tyr Ala Giu Lys 220 I le Ser Gly Ala Ser 300 Gly *Val *Val Ala *Phe Asp Val Asn Phe Cys Leu Cys Asn 125 Ser Ile Gly Arg Pro 205 Leu Phe Ile Thr Leu 285 Val1 Val Giu Cys Lys 365 Pro Ser krg kia Ser 1ly k.sn ksp 110 rhr Val1 Gly Ala Phe 190 Arg Leu Lys Gly Ile 270 Gin Val1 Leu Ile Ser 350 Arg Pro Ile Ala Gly Phe Pro Lys Leu Leu Asp Leu Phe Phe Giu His Pro Leu Leu Asp Ile Val 160 Giu Cys 175 Giu Giu Arg Leu Lys Arg Gin Met 240 Arg Leu 255 Ser Phe Ser Asp Arg Leu Giu Pro 320 Ile Thr 335 Gly Gly Leu Lys Asn Asp 380 Gly Gin Ala Leu Met Ala Tyr Phe Asn Pro Thr 390 Gly 405 INFORMATION FOR SEQ ID NO:1670: SEQUENCE CHARACTERISTICS: LENGTH: 446 amino acids PCT/US 9/0912 2 IPEA/US 18 DEC1996 1213 TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...446 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1670 Arg 1 Leu Ile Arg Asp Ile Gly Tyr Phe Leu 145 His Pro Ser Val Thr 225 Met Glu Pro Ser Asp 305 Met Phe Ala Leu Phe Glu Cys Gly Ala Ser Asp Met Ser Gly Pro Gly Leu Tyr Ser Leu Thr Leu 130 Leu Leu Glu Ser Arg 210 Ile Gly Asp Trp Thr 290 Phe Thr Ile Trp Phe Gly Leu Arg Phe Ala Val Tyr 115 Gly Met Gly Asn Leu 195 Phe Gly Leu Pro Ile 275 Ala Tyr Ile Ser Ala 355 Trp Ala Ser Ile Glu Phe Ser 100 Ala Arg Met Gly Leu 180 Ala Met Ile Leu Glu 260 Thr Ser Ala Ser Thr 340 Gly Ser 5 Leu Leu Tyr Thr Val Gly Leu Tyr Ser Ile 165 Ser Trp Ser Ser Gly 245 Lys Gly Ser Thr Arg 325 Asp Phe Arg Tyr Gly Thr Arg 70 Ile Ala Ser Lys Ala 150 Gly Phe Gly Ile Trp 230 Val Ile Ile Gin Ile 310 Leu Lys Gly Met Val Ala Ser 55 Phe Leu Lys Ile Ala 135 Leu Glu Leu Leu Arg 215 Met Ala Phe Leu Leu 295 Phe Ser Asn Ala Thr Gly Leu 40 Val Ser Ile Leu Gly 120 Val Ile Gly Gin Gly 200 Ser Val Tyr Ile Leu 280 Leu Asn Val Ala Ser 360 Arg Gly 25 Ile Ile Asp Leu Phe 105 Thr Cys Val Ile Gly 185 Tyr Ile Ile Val Val 265 Ser Val Lys Leu Ser 345 Phe Ile 10 Leu Asn Ala Asp Lys 90 Glu Leu Trp Val Lys 170 Ser Phe Arg Ser His 250 Met Ala Ser Asn Gly 330 Ile Gly Gly Asp Ile Trp Asn Lys 75 Ile Pro Ile Thr Pro 155 Ile Ser Gly Asp Leu 235 Lys Ser Ile Ser Ala 315 Val Leu Ser Ala Lys Trp Asn Val Ser His Phe Thr Ile Asp 140 Ile Ile Val Gin Val 220 Ile Phe Gin Leu Ser 300 Pro Ala Ser Val Ile 380 Phe Leu Ser Phe Ile Ile Tyr Phe Val 125 Leu Val Lys Val Pro 205 Pro Gly Asp Leu Ala 285 Thr Gin Cys Ile Ile 365 Ala Gly Leu His Val Thr Leu Phe Gly 110 Ser Ile Met Glu Ala 190 His Lys Ala Leu Leu 270 Ala Ile Lys Ile Val 350 Leu Gly Lys Met Ile Ala Ile Arg Ser Ile Tyr Gln Ile Ile 175 Ile Ile Ala Cys Ser 255 Phe Val Ala Leu Ala 335 Ser Phe Met Ser Gly Ala Lys Ser Leu Ser Gin Thr Gly Ile 160 Lys Ile Leu Thr Val 240 Leu Asn Met Glu Val 320 Phe Tyr Ser Leu Phe 370 375 Ser Gly Ala Ser Thr Val Ile Leu Tyr 1~ 385 Leu Ile Ala PCT/US 96/09122 IPEAIUS 18 D Ci996 390 395 400 Ile Tyr Glu Ile Val Pro Gly Phe Ile Val Ala Ser Val Ala 405 410 415 Ala Phe Ser Leu Phe Ser Ser Val Arg Ser Gly Thr Lys Glu 420 425 430 Glu Thr Met Leu Lys Glu Ile Glu Ser Leu Lys His 435 440 445 INFORMATION FOR SEQ ID NO:1671: SEQUENCE CHARACTERISTICS: LENGTH: 375 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...375 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1671 Asn Lys Trp Ile Lys Gly Ala Val Val Phe Val 1 Ile Asn Gin Ser Leu Phe Phe Lys Asn 145 Ala Ile Val Val Asn 225 Thr Ile Thr Asn Asp Lys Lys Thr Ser Gin 130 Pro Thr Pro Ile Leu 210 Lys Pro Lys Thr Gin Tyr Asp Ala Ser Pro 115 Ser Asn Asn Ala Ala 195 Ile Met His Gly Phe Pro Thr Ala Leu Pro 100 Lys Pro Gly Glu Phe 180 Gin Pro Gly Gly Tyr 260 5 Ser Ser Phe Thr Asn Pro Gin Lys Ile Asn 165 Leu Val Lys Glu Ile 245 Asn Leu Leu Thr Ile 70 Ser Met Leu Asn Asp 150 Lys Ile Glu Gly Tyr 230 Asn Gly Ile Leu Gin 55 Lys Lys Asp Asp Tyr 135 Ser Leu Thr Ser Ser 215 Arg Ile Leu Tyr Asn 40 Asn Ala Glu Pro Leu 120 Glu Phe Leu Pro Asp 200 Lys Leu Met Val His 25 Asp Pro Leu Met Lys 105 Leu Glu Thr Arg Ile 185 Ile Val Asp Leu Gly 265 Leu 10 Gin Asp Gin Gin Asn 90 Thr Ala Asn Asn Thr 170 Ser Phe Ile Ile Thr 250 Glu Ser Lys Glu Pro Glu 75 Tyr Thr Ser Leu Leu 155 Ile Ser Ala Gly Val 235 Asn Leu Thr Gly Pro Val Thr Gln Ser Pro Arg Ile 140 Lys Thr Gin Ser Tyr 220 Trp Ala Ile Leu Gly Lys Lys Asn Leu Lys Pro Ile 125 Phe Glu Ala Ile Met 205 Tyr Ser Lys Glu Thr 285 Phe Ala Thr Ala Pro Leu Tyr Pro Leu Thr Glu Ser Lys Ala Ala Glu Glu Thr Lys Lys Asp 110 Thr Pro Phe Pro Val Asp Lys Asp Ile 160 Asp Lys Met 175 Ala Gly Lys 190 Gly Lys Ala Ser Asn Asn Arg Ile Ile 240 Gly Ala Asp 255 Arg Asn Phe 270 Asn Gly Leu Gin Arg Tyr Gly Val Pro Leu Leu WIEND!ED SHET PCT/US 9 6/0 91 2 IPENUS 18 DEC 1996 1215 Leu Ile Gly Ile Thr Ser Ala Leu Asn Asn Arg Gly Asn Lys Glu Glu 290 295 300 Val Thr Asn Phe Phe Gly Asp Tyr Leu Leu Leu Gln Leu Met Arg Gin 305 310 315 320 Ser Gly Met Gly Ile Asn Gln Val Val Asn Gln Ile Leu Arg Asp Lys 325 330 335 Ser Lys Ile Ala Pro Ile Val Val Ile Arg Glu Gly Ser Arg Val Phe 340 345 350 Ile Ser Pro Asn Thr Asp Ile Phe Phe Pro Ile Pro Arg Glu Asn Glu 355 360 365 Val Ile Ala Glu Phe Leu Lys 370 375 INFORMATION FOR SEQ ID NO:1672: SEQUENCE CHARACTERISTICS: LENGTH: 121 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...121 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1672 Lys Ala Ala Phe Cys Ile Gly Ile Phe Phe Tyr Gly Ala Tyr Tyr Phe 1 5 10 Leu Asp Glu Phe Leu Ile Lys Leu Tyr Leu Gln Pro Ser Glu Gln Asp 25 Ala Leu Phe Met Gln Glu Thr Lys Arg Ala Met Asn Ile Tyr Tyr Val 40 Gly Tyr Val Phe Leu Gly Met Thr Leu Leu Cys Ala Val Phe Phe Gin 55 Ser Ile Gln Arg Thr Lys Ser Ser Phe Ile Ile Thr Ile Ser His Thr 70 75 Leu Gly Phe Ile Val Ile Leu Leu Pro Ile Leu Ser His Phe Tyr Gly 90 Val Asn Gly Ile Trp Val Thr Tyr Pro Ile Ala Gln Phe Leu Ala Val 100 105 110 Phe Gly Ser Val Arg Gly Asn Leu Leu 115 120 INFORMATION FOR SEQ ID NO:1673: SEQUENCE CHARACTERISTICS: LENGTH: 130 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori PCT/US 96/09122 IPEA/US 18 DEC1996 1216 (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...130 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1673 Met Leu Lys Lys Lys Ile Asp Leu His Lys Asp Ser Ile Arg Lys Leu 1 5 10 Phe Phe Tyr Tyr Phe Ile Pro Leu Val Phe Ser Met Ile Ser Leu Ser 25 Thr Tyr Ser Met Val Asp Asp Met Phe Val Gly Lys Lys Leu Gly Lys 40 Glu Ala Ile Ala Ala Val Asn Ile Ala Trp Pro Ile Phe Pro Gly Leu 55 Ile Ala Tyr Glu Leu Leu Phe Gly Phe Gly Ala Ala Ser Ile Val Gly 70 75 Tyr Phe Leu Gly Gln Asn Lys Thr His Arg Ala Arg Leu Val Phe Ser 90 Ser Val Phe Tyr Phe Val Ala Leu Ser Ala Phe Ile Leu Ser Met Ala 100 105 110 Leu Leu Pro Phe Ser Glu Asn Ile Ala Arg Phe Leu Gly Ala Met Thr 115 120 125 Leu Tyr 130 INFORMATION FOR SEQ ID NO:1674: SEQUENCE CHARACTERISTICS: LENGTH: 161 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...161 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1674 Asn His Phe Asn Gly Cys Val Phe Arg Val Gln His Leu Leu Ala Asp 1 5 10 Val Phe Val Val Asn Asp Lys Arg Pro Val Leu Ala Met Val Ala Met 25 Leu Ile Gly Ser Leu Ala Asn Ile Phe Phe Asn Tyr Leu Phe Ile Phe 40 Val Leu Glu Val Gly Val Gln Gly Ser Ala Ile Ala Thr Val Ile Gly 55 His Ala Ile Gly Val Leu Val Leu Met Gln His Phe Trp Arg Lys Lys 70 75 Gly Gln Leu Tyr Phe Ile Lys Arg Phe Ser Leu Ser Ser Val Ile Ser 90 Ser Ala Lys Ser Gly Val Pro Gln Ser Thr Ala Glu Phe Ser Ala Ser 100 105 110 Ile Met Ile Leu Leu Phe Asn Thr Ala Ile Met His Thr Ala Gly Glu 115 120 125 Arg Phe Val Ser Met Tyr Gly Ile Val Met Tyr Asn Ala Ile Ile Phe 130 135 140 #L 7 7DSI-~F PCT/US 9 /09122 IPENUS 18 DEC 1996 1217 Phe Thr Thr Leu Phe Ala Ile Ser Gin Gly Ile Gin Pro Ile Ala Glu 145 150 155 160 Leu INFORMATION FOR SEQ ID NO:1675: SEQUENCE CHARACTERISTICS: LENGTH: 426 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...426 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1675 Phe Leu Asn Ile Arg Asp Leu Thr Met Ile Phe Ser Ser Leu Phe Ser 1 5 10 Val Val Gly Met Ala Val Leu Phe Leu Ile Ala Trp Val Phe Ser Gly 25 Asn Lys Arg Ala Ile Asn Tyr Arg Thr Ile Val Ser Ala Phe Val Ile 40 45 Gin Val Ala Leu Gly Ala Leu Ala Leu Tyr Val Pro Leu Gly Arg Glu 55 Ile Leu Gln Gly Leu Ala Ser Gly Ile Gln Ser Val Ile Gly Tyr Gly 70 75 Tyr Glu Gly Val Arg Phe Leu Phe Gly Asn Leu Ala Pro Asn Ala Lys 90 Gly Asp Gin Gly Ile Gly Gly Phe Ile Phe Ala Ile Asn Val Leu Ala 100 105 110 lie lie Ile Phe Phe Ala Ser Leu Ile Ser Leu Leu Tyr Tyr Leu Lys 115 120 125 Ile Met Pro Leu Val Ile Asn Leu Ile Gly Gly Ala Leu Gln Lys Cys 130 135 140 Leu Gly Thr Ser Lys Ala Glu Ser Met Ser Ala Ala Ala Asn Ile Phe 145 150 155 160 Val Ala His Thr Glu Ala Pro Leu Val Ile Lys Pro Tyr Leu Lys Ser 165 170 175 Met Ser Asp Ser Glu Ile Phe Ala Val Met Cys Val Gly Met Ala Ser 180 185 190 Val Ala Gly Pro Val Leu Ala Gly Tyr Ala Ser Met Gly Ile Pro Leu 195 200 205 Pro Tyr Leu Ile Ala Ala Ser Phe Met Ser Ala Pro Gly Gly Leu Leu 210 215 220 Phe Ala Lys Ile Ile Tyr Pro Gln Asn Glu Thr Ile Ser Ser His Ala 225 230 235 240 Asp Val Ser Ala Glu Glu His Val Asn Ile Ile Glu Ala Ile Ala Asn 245 250 255 Gly Ala Ser Thr Gly Leu His Leu Ala Leu His Val Gly Ala Met Leu 260 265 270 Leu Ala Phe Val Gly Met Leu Ala Leu Val Asn Gly Leu Leu Gly Val 275 280 285 Val Gly Gly Phe Leu Gly Met Glu His Leu Ser Leu Gly Val Val Leu 290 295 300 Gly Thr Leu Leu Lys Pro Leu Ala Phe Met Leu Gly Val Pro Trp Ser PCT/US 9 091 2 IPEA/US 18DEC1996 1218 305 310 315 320 Gin Ala Gly Ile Ala Gly Glu Ile Ile Gly Ile Lys Ile Ala Leu Asn 325 330 335 Glu Phe Val Gly Tyr Met Gln Leu Leu Pro Tyr Leu Gly Asp Asn Pro 340 345 350 Pro Leu Ile Leu Ser Glu Lys Thr Lys Ala Ile Ile Thr Phe Ala Leu 355 360 365 Cys Gly Phe Ala Asn Leu Ser Ser Val Ala Met Leu Ile Gly Gly Leu 370 375 380 Gly Ser Leu Val Pro Lys Lys Lys Asp Phe Ile Ala Arg Leu Ala Leu 385 390 395 400 Lys Ala Val Leu Val Gly Thr Leu Ser Asn Phe Met Ser Ala Thr Ile 405 410 415 Ala Gly Leu Phe Ile Gly Leu Ser Ala Asn 420 425 INFORMATION FOR SEQ ID NO:1676: SEQUENCE CHARACTERISTICS: LENGTH: 316 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...316 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1676 Thr Leu Ser Lys Glu Glu Gly Leu Met Pro Gln Asn Gln Leu Val Ile 1 5 10 Thr Ile Ile Asp Glu Ser Gly Ser Lys Gln Leu Lys Phe Ser Lys Asn 25 Leu Lys Arg Asn Leu Ile Ile Ser Val Val Ile Leu Leu Leu Ile Val 40 Gly Leu Gly Val Gly Phe Leu Lys Phe Leu Ile Ala Lys Met Asp Thr 55 Met Thr Ser GIu Arg Asn Ala Val Leu Arg Asp Phe Arg Gly Leu Tyr 70 75 Gin Lys Asn Tyr Ala Leu Ala Lys Glu Ile Lys Asn Lys Arg Glu Glu 90 Leu Phe Ile Val Gly Gln Lys Ile Arg Gly Leu Glu Ser Leu Ile Glu 100 105 110 Ile Lys Lys Gly Ala Asn Gly Gly Gly His Leu Tyr Asp Glu Val Asp 115 120 125 Leu Glu Asn Leu Ser Leu Asn Gln Lys His Leu Ala Leu Met Leu Ile 130 135 140 Pro Asn Gly Met Pro Leu Lys Thr Tyr Ser Ala Ile Lys Pro Thr Lys 145 150 155 160 Glu Arg Asn His Pro Ile Lys Lys Ile Lys Gly Val Glu Ser Gly Ile 165 170 175 Asp Phe Ile Ala Pro Leu Asn Thr Pro Val Tyr Ala Ser Ala Asp Gly 180 185 190 Ile Val Asp Phe Val Lys Thr Arg Ser Asn Ala Gly Tyr Gly Asn Leu 195 200 205 Val Arg Ile Glu His Ala Phe Gly Phe Ser Ser Ile Tyr Thr His Leu 210 215 220 PO/US 9 6/O091 I PEAAJS 18 DE C199 6 Asp 225 Ile Tyr Ala Ile Gin 305 1219 Ile Gin 235 Gly Gly Asp Ala Leu Giu Giu Asp 300 Gly Gin 315 Gin Leu 255 Phe Lys Gin Leu 240 His Leu Phe Leu INFORMATION FOR SEQ ID NO:1677: SEQUENCE CHARACTERISTICS: LENGTH: 315 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .315 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1677 1Gy Phe Leu Val Phe Leu Asp Arg Arg Leu Ile Val Met Val Thr Asp S1 Ser Val His Lys Gly Giu Gly Asp i4 5 Arg Leu Val1 Lys Lys Lys Leu Ser Ala Leu Giu Giu Ile 130, Tyr Met Sen Gly Val1 210 Ile Gly Tyr Leu Leu Sen Ang Giu 115 Thn Pro His Thr Leu 195 Phe Val1 Ser 20 Ala Leu Ile Leu Ile 100 Lys Gly Leu Pro Ala 180 Ala His Val1 Arg Leu Val1 Thr Gin Asn Giu Leu Giu Ile 165 Ile Sen Pro Lys Tryr Ilie Leu Ser Leu Asn 55 Lys Giu 70 Met Asp Asp Leu Giu Giy Gin Lys 135 Ser Tyr 150 Leu His Asn Thr Lys Gly Phe Gly 215 Thr dly 230 Asn Val 40 Lys Phe G iu Giu Asn 120 Ser Ang Val Pro Trp 200 Phe Glu Val1 25 Val Giu G iu Phe Giu 105 Phe Phe Ang Leu Val 185 Asn Lys Phe His Gly Ile Lys Leu 90 Val1 Ser Ile Val1 His 170 Tyr Gly Thr Val Ile Ser Lys Lys 75 Asp Val1 Sen Met Sen 155 Asn Ala Gly Tyr Lys 235 Leu Leu Asn Arg Asp Gly Ang Arg 140 Ala His Sen Tyr Tyr 220 Lys Pro Phe Leu Ile Giu Leu Val1 Leu 125 Leu Ala Thr Ala Gly 205 Aia G iy His A.rg Phe Glu Thn Gin Asn 110 Asp Ile Phe Gly Sen 190 Asn His Gin Leu Gin Leu4 Lys Asn Leu Arg Val Pro Asn Leu 175 Gly Leu Leu Leu His Ile Giy Gln Giu Ser Pro Aia Asn Lys 160 Asp Vai Ile Asn Ile 240 Tyr Gly Tyr Ser Gly Asn Thr Gly Met Sen Thn Gly PCT/US 9 6/O091 2.
I P E/tIS 18D0ECr,19 9 1220 Giu Trp Arg Asp 305 245 250 255 Arg Phe Leu Asp Gin Pro Ile Asn Pro Met Ser Phe Thr Lys 260 265 270 Met Lys Asp Phe Giu Giu Val Phe Asn Lys Glu Arg Ser Ile 275 280 285 Gin Ser Leu Ile Thr Ile Ile Asn Arg Leu Met Gin Lys Gin 295 300 Arg Leu Ser Ser Leu Lys Ala Pro Lys 310 315 INFORMATION FOR SEQ ID NO:i678: SEQUENCE CHARACTERISTICS: LENGTH: 460 amino acids TYPE: amino acid TOPOLOGY: iinear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyiori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .460 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:i678 Asp Ile Giu Phe Ala Asn Leu Tyr His Ile Pro Ile Lys Val Ile Thr 1 Gin Ser Leu Arg Ile Leu Pro His Ser 145 Asn Thr Arg Giu Ala 225 Leu Ser Gly Pro Leu Pro Pro Leu Lys 130 Ser Gin Tyr Phe Pro 210 Lys Lys Pro Giu Tyr Gin Met Val Lys 115 Asp Trp Aia Ile Phe 195 Phe Met Lys Gin Trp Phe Asn Ile Thr 100 Lys Ala Tyr Phe Gly 180 Thr Lys Ser Tyr 5 Asn Ser Asp Trp His Leu His Leu Phe Asp 165 Gly Lys Gin Lys Giy 245 Leu Asp Lys Gly 70 Cys Pro Ala Val Leu 150 Gin Ile Ala Leu Ser 230 Ala Pro Leu Giu 55 Val Lys Giu Ser G iu 135 Arg Asn Giu Leu Ile 215 Lys Asp His Ser 40 Asn Ser His Asp Trp 120 Thr Tyr Tyr His Arg 200 Thr Giy Ala Giu Thr 25 Ser Leu Arg Cys Ile 105 Arg Asp Thr Leu Ala 185 Asp Gin Asn Vali Trp 265 10 Lys Ser Gly Gin Gly 90 Val1 Phe Thr Thr Lys 170 Ile Leu Giy Val1 Arg 250 Asn Giu Leu Lys Arg 75 Ile Ile Ala Met Pro 155 Tyr Leu Gly Met Val1 235 Leu Asp Giu Ala Arg Tyr Val1 Asp Gin Asp 140 Lys Phe His Tyr Val1 220 Ser Phe Asn Ile Arg Val Trp Pro Gly Cys 125 Thr Asn Met Leu Leu 205 Leu Pro Ile Ala Leu Lys Ile Gly.
Giu Giu 110 Pro Phe Gin Pro Leu 190 His Lys Lys Leu Leu 270 Lys Lys Asn Ala Thr Gly Arg Ile Arg Val 175 Tyr Leu Asp Glu Phe 255 Glu Asn Ile Tyr Pro Gin Asn Cys Gin Giu 160 Asp Ala Asp Gly Ile 240 Ala dly Ala Pro Pro Ala Lys Giu Leu 260 PEk'IS 18UL DE0S196 1221 Ala Pro Gin 305 Giu Ala Gin Met Giu 385 Phe Lys Lys Tyr His Thr 290 Lys Ile Ser Ile Ile 370 Asn Met Vali Giu Val1 450 Phe Ser Aia Asn Met 340 Cys His Lys Leu Ile 420 Giu Asn Ile Lys Arg Lys 325 Giu Giu Thr Pro Gly 405 Asn Lys Lys Lys Pro Lys 310 Ala Ala Giy Ala Ile 390 Leu Ala Tyr Leu Arg Giu 295 Lys Giu Leu Tyr Trp 375 Giu Thr Ser Leu Val1 455 Leu 280 Phe Vali Ser Asn Phe 360 Giu Val1 Ile Lys Giu 440 As n Tyr Lys Tyr Aia Ala 345 Val1 Leu Asp Asn Giu 425 Asn Phe Ala Gly 300 Leu Phe Ala Gin Arg 380 Aia Arg Ile Val1 Ala 460 As n 285 Leu Lys Asn Gin Ile 365 Leu Leu Arg Ile Lys 445 Ala Asn Lys Thr Ser 350 Leu Phe Ile Ala Leu 430 Lys Ile Giu Ser Leu 335 Asp Giu Lys Glu Giu 415 Ala Glu INFORMATION FOR SEQ ID NO:1679: SEQUENCE CHARACTERISTICS: LENGTH: 403 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .403 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:i679 1Leu Asn Leu Trp Leu Lys Ser Leu Met Arg Gly Asn Sen Ile Met Lys Asn His Asn Asn Gin Arg Giu Ser Cys Ser Lys Ala Gly Gly Glu Asn Tyr 130 Asp His Phe Phe Lys Phe Arg Ala 115 Phe Tyr Gly Asp Phe Gly Lys Phe 100 His Glu Leu Leu Pro Giu Ser Val Tyr Gin Tyr Val1 Ala Arg Gin 55 Gly His As n Leu Thr 135 Glu Phe Phe 40 Ala Arg Phe Gly Gin 120 Leu Ala Leu 25 Ile Lys Phe Thr Ser 105 Sen Leu Gly Glu Gln Val1 Leu Sen 90 Val1 His Ala Leu Thr Ile Ile Thr 75 Pro Val1 Ala Val1 Gly Lys Tyr His Leu His Lys Phe Met 140 Gly Pro Lys Val Leu Val1 Giu Se r 125 Leu Glu Lys Asp Val1 Leu Phe Ser 110 Asn Ala Phe Giu Phe Gly Ala Giu Val1 Ala Lys Asp Tyr Lys Thr Asp Phe Leu Cys Asp Sen LW L$IS I uoD U99 6 1222 145 Thr Asp Lys Leu Leu 225 Glu Leu Lys Pro Leu 305 Tyr Lys Ile Giu Tyr 385 Lys Ala Lys Lys 195 Leu Val His Ala Leu 275 Ile Giu Cys Val1 Gin 355 Ala Ser Asp Leu Giu 180 Ala Asn Val1 His Phe 260 Lys Leu Glu Tyr Val1 340 Leu Leu Phe Glu 165 Phe Met Val Gin Leu 245 Giu Pro Ile Ile Gin 325 Lys Glu Phe Leu 150 Lys Leu Gly Ala Asn 230 Ala Thr Leu Asp Lys 310 Asp Lys Lys Giu Val1 390 Thr Gly Ser Gin 215 Glu His Leu Asp Val1 295 Arg Lys Val1 Leu Giu 375 Ala Ser Ser 185 Asn Ile Ser Leu Pro 265 Ile His Phe Ala Ile 345 Gly Lys Ala Val1 170 Leu Ile Ala Lys Ala 250 Cys Gly Asn As n Phe 330 Leu Ile Glu Phe 1S5 Phe Giu Ile Lys Giy 235 Met Asn Arg Pro Ala 315 Leu Giu Leu Asn Tyr 395 Thr Ser Ala Asp 220 Val1 Asn Lys Cys His 300 Pro Val1 Leu Giu Giu 380 G iu Pro Ile Pro 205 Lys Ser Leu Gin Giu 285 Ser Ile Leu His Thr 365 Asn Arg Ile Ala 190 Gin His Asp Glu Giu 270 Leu Ala Val1 Giu Asn 350 Leu Tyr Tyr 160 Tyr Thr Glu Gin Ile 240 Ala Leu Ser Ala Ile 320 Leu Arg Leu Val1 Lys 400 INFORMATION FOR SEQ ID NO:1680: SEQUENCE CHARACTERISTICS: LENGTH: 227 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .227 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1680 *Val Ser Ser His Sen Gly Ser Ala Asp Leu Leu 10 *Asn Ile Glu Met Asn Pro Met Gin Leu Giu Asn 25 7His Phe Gly Phe Leu Phe Ala Pro Leu Tyr His 40 Ser Ala Pro Leu Arg Lys Glu Leu Phe Thr Lys 55 Leu Gly Pro Leu Ile Asn Pro Leu Arg Pro Lys 75 Glu Asn Leu Gly Cys Phe Lys Gin Gin Ser Phe Lys Thr Ile Phe Asn Ile Gin Leu Leu POT/US 9 6 0 IPEA/JS 18 DEC1996 Gly Ala Glu Glu Tyr 145 Ala Val Lys Gin Leu 225 Asp Val 100 Leu Glu Lys Asp Ala 180 Lys Leu Lys Lys His Tyr Glu Ile 165 Asn Arg Cys Ser Arg Asp Asp Leu 150 Leu Val Gly Ala Leu Ala Ile Leu 135 Gin Glu Ala Arg Phe 215 1223 Met Ala Asn Gly Cys Glu Asp Phe 140 Ala Lys 155 Lys Asp Tyr Leu Phe Arg His Lys 220 Lys Asp Asn Pro Gin 160 Met Ala Asn Cys INFORMATION FOR SEQ ID NO:1681: SEQUENCE CHARACTERISTICS: LENGTH: 294 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...294 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1681 Asn Leu Val Val Ser Val Pro Ala Thr Ser Ala Asn Leu Gly Pro Gly 1 Phe Glu Ile Ile Asn Val Arg Asn Lys 145 Ala Asp Pro Pro Leu Lys Gly Glu Ile 130 Lys Val Cys Ser Lys Lys Val Ala Asn 115 Thr Lys Met Leu Asn Phe Lys Pro Val 100 Ile Pro Val Val 5 Gly Ile Leu His Ile Ala Leu Ala Ile Ile Leu His Thr Gly 70 Thr Ser Asn Val Ser 150 Pro Ser Ala Asn 55 Asn Arg Ala Thr Phe 135 Leu Asn Leu Val 40 Asn Asp Gly Phe Ala 120 Gly Lys Arg Asn 25 Lys Ile Gly Met Ala 105 Leu Gly Thr Val Val 10 Leu Leu Phe Ser Gly 90 Phe Ile Tyr Lys Ile 170 Gin Arg Val Thr Phe 75 Ser Leu Tyr Asn Ile 155 Ser Glu Asn Gly Lys Lys Ser Gly Glu Ala 140 Pro Thr Ser Arg Glu Val Phe Ser Phe Asn 125 Ala Ser Lys Val Phe Phe Gly Glu Phe Tyr Leu Leu Ala Met Ala Phe 110 His Pro Phe Val Phe Leu Gin Ser 175 Phe Asn Ile Gly Glu His Ile Asp Asp Glu Lys 160 Arg Leu 165 His Leu Leu Pro Lys Arg Tyr Ser PGT/US 9 6/0 912.2 IPENMS 18 DEC 1996 1224 180 Ser Cys Pro Met Giu 260 Lys Giu Leu Cys Val1 Ser 245 Giu Phe Lys Met Ser Leu 230 Thr Asp Arg Asp 185 Ala Arg Ile Gly Lys 265 Val1 Ile Met Gin Ser 250 Leu Leu INFORMATION FOR SEQ ID NO:i682: SEQUENCE CHARACTERISTICS: LENGTH: 298 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION I1.. .298 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:i682 Leu Val Phe Lys Lys Pro Phe Phe Lys Asn Arg Leu Leu Asn Vai Thr Asn His Lys Ala Leu Gin Val1 Thr Pro 145 Lys Ser Ile Lys Tyr Gin Met Arg Asn Leu His 130 Asn Tyr Lys Ser Leu Cys Giy Ala Lys Pro Lys 115 Ile Phe Gly Lys Leu 195 Lys Arg Ala Ile Ile Ser 100 Asp Ser Phe Lys G iy 180 Asp Phe Lys Lys Ile Val Pro Ile Gly Pro 165 Arg Val1 Val Ile Lys Val1 70 Phe Cys Asn Ile Leu 150 Ile Ser Arg Lys Thr Met 55 Vali Glu Ile Gly Giu 135 Ser Pro Gin Lys Leu 215 Ile Arg 40 Lys Ser Lys Glu Pro 120 Asn Trp Asp As n Gin 200 Sex Thr 25 Gly Lys Leu Cys Val1 105 Leu Pro Gin Tyr His 185 Leu Giy Ile Phe Ala Asn Leu 90 Lys Gin Leu Aia Aia 170 Phe Asp Gly Met Vali Giy Ala 75 Pro Pro Tyr Leu Arg 155 Ile His Asn Leu Ile Lys Phe Lys Asn Asp Leu Leu 140 Asp Ser Ile Asn Asn 220 Lys Ile Leu Asp Tyr Aia Leu 125 Asp Phe Leu His Leu 205 Giy k.sp Pro Phe Pro Glu Giy 110 Met Pro Met Thr I le 190 Lys H i.
Phe2 Thr Leu Asn Lys Tyr Pro Ser Ser Ile 175 Ser Asn Lys ksn Lys Alia A.sn Val Thr Thr Lys 160 Asn Cys Ile Tyr Asn Ser 210 Arg Trp Ser Pro PCT/'S 9 6 /19 IPENUS louL 996 1225 Leu Ala Arg Arg Val Thr Glu Ser Glu Leu Ala Gln Lys Ser Pro Phe 225 230 235 240 Val Met Leu Ala Lys Glu Val Pro Asn Ala His Lys Arg Met Gly Asp 245 250 255 Tyr Gly Leu Ala Val Val Gln Gln Ser Asp Asn Ser Phe Val Leu Leu 260 265 270 Ala Thr Gln Phe Asn Pro Leu Thr Leu Asn Arg Ala Ser Ala Glu Glu 275 280 285 Ile Gln Asp His Glu Cys Ala Ile Leu Arg 290 295 INFORMATION FOR SEQ ID NO:1683: SEQUENCE CHARACTERISTICS: LENGTH: 121 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...121 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1683 Tyr His Arg Thr Asn Thr Thr Ile Arg Ile Ile Ile Met Gln Asp Leu 1 5 10 Pro Pro Cys Pro Lys Arg Asn Asp Ala Tyr Thr Tyr His Asp Gly Thr 25 Gin Phe Val Cys Ser Ser Cys Leu Tyr Glu Trp Asn Gly Asn Glu Ile 40 Ser Asn Glu Glu Leu Ile Val Lys Asp Cys His Asn Asn Leu Leu Gin 55 Asn Gly Asp Ser Val Ile Leu Ile Lys Asp Leu Lys Val Lys Gly Ser 70 75 Ser Leu Val Leu Lys Lys Gly Thr Lys Ile Lys Asn Ile Lys Leu-Val 90 Asn Ser Asp His Asn Val Asp Cys Lys Val Giu Gly Gln Ser Leu Ser 100 105 110 Leu Lys Ser Glu Phe Leu Lys Lys Ala 115 120 INFORMATION FOR SEQ ID NO:1684: SEQUENCE CHARACTERISTICS: LENGTH: 75 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: POT/Ir '/n9122 IPEAUS 18 0E0 1996 1226 NAME/KEY: misc_feature LOCATION 1...75 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1684 Lys Gly Cys Phe Met Arg Glu Phe Phe Lys Lys Leu Gly Thr Glu Tyr 1 5 10 Ala Ser Lys Leu Phe Leu Val Tyr Trp Leu Arg Trp Met Leu Ser Ala 25 Leu Val Met Leu Pro Phe Met Glu Val Phe Tyr Tyr Phe Asn Phe Pro 40 Leu Trp Leu Asn Leu Phe Leu Gly Gln Thr Ile Gly Ala Val Ile Phe 55 Phe Lys Leu Asp Lys Leu Ile Phe Ser Lys Lys 70 INFORMATION FOR SEQ ID NO:1685: SEQUENCE CHARACTERISTICS: LENGTH: 497 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...497 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1685 Phe Phe Lys Arg Tyr Glu Arg Leu Ser Met Gln Tyr Ser Ser Leu Leu 1 5 10 Ser Val Val Leu Phe Leu Pro Leu Ile Gly Ala Val Tyr Ala Gly Leu 25 Phe Gly Ala Lys Ala Lys Ala Leu His Val Gly Val Phe Asn Ser Leu 40 Cys Val Leu Val Ser Phe Ile Gly Ala Val Val Leu Phe Ile Gln Ala 55 Trp His His Gln Ser Tyr Glu Lys Tyr Leu Phe Asp Trp Ile Val Val 70 75 Gly Asn Phe Lys Val Gly Phe Ser Leu Met Leu Asp Asn Ile Asn Ala 90 Val Met Ile Val Val Val Thr Leu Val Ser Phe Leu Val His Val Tyr 100 105 110 Ser Ile Gly Tyr Met Glu His Asp Thr Gly Phe Asn Arg Tyr Phe Ser 115 120 125 Tyr Leu Ser Gly Phe Val Phe Ser Met Leu Val Leu Val Leu Ser Asp 130 135 140 Asn Phe Leu Gly Leu Phe Ile Gly Trp Glu Gly Val Gly Leu Cys Ser 145 150 155 160 Tyr Leu Leu Ile Gly Phe Trp Tyr His Lys Lys Ser Ala Asn Asn Ala 165 170 175 Ser Ile Glu Ala Phe Val Met Asn Arg Ile Thr Asp Leu Gly Met Leu 180 185 190 Met Gly Ile Ile Leu Ile Phe Trp Asn Phe Gly Thr Leu Gln Tyr Lys 195 200 205 Glu Val Phe Ser Met Leu Asn Asn Ala Asp Tyr Ser Met Leu Phe Tyr 210 215 220 PT/US 96/091?? IPENUS 18 DE G 996 1227 Ile Ser Val Phe Leu Phe Ile Gly Ala Met 225 230 Pro Met Ser Ala lie Ile Phe Ile 290 Ala Leu 305 Ser Gin Ile Ala Phe Leu Ile Thr 370 Phe Met 385 Gly Tyr His His Phe Tyr His Glu 450 His Ala 465 Ala Val Ile His Leu Arg 275 Ala Val Leu Leu Gly 355 Lys Ile Phe Ile Ser 435 Ile Thr Phe Thr Ile 260 Ala Cys Asn Gly Phe 340 Ser Met Ile Ser Leu 420 Phe Asn Val Ser Trp 245 His Asn Leu Lys Tyr 325 His Gly Gly Gly Lys 405 Trp Arg His Arg Phe 485 Leu Ala Pro Gly Asp 310 Met Leu Asn Ala Ser 390 Asp Phe Leu Pro Gly 470 Tyr Ala Ala Leu Ala 295 Leu Phe Phe Val Leu 375 Val Lys Val Ile His 455 Phe Leu Asn Thr Tyr 280 Phe Lys Val Thr Met 360 Tyr Ala Ile Leu Met 440 Glu Gly Ser Ala Met 250 Met Val 265 Ser Ala Val Ala Arg Ile Ala Ala 330 His Ala 345 His Ala Lys Pro Leu Cys Leu Glu 410 Leu Ile 425 Leu Val Gly Gin Gly His Ser Glu 490 Gly Lys 235 Glu Gly Thr Ala Val Phe Leu Phe 300 Val Ala 315 Gly Leu Phe Phe Met Glu Met Arg 380 Gly Ile 395 Val Ala Gly Ala Phe Phe Lys Phe 460 Cys Arg 475 Phe Leu Ser Pro Gly Glu 285 Gly Tyr Gly Lys Asp 365 Ile Tyr Phe Ile Ala 445 His Phe Val Ala Thr Val 270 Val Ala Ser Ala Ser 350 Asn Thr Pro Gly Phe 430 Pro Ala Phe Leu Gin Pro 255 Tyr Gly Ser Thr Tyr 335 Leu Leu Ala Phe Met 415 Thr Lys Phe Arg Glu 495 Phe 240 Val Leu Tyr Met Leu 320 Ala Leu Asp Val Ala 400 His Ala Gin Glu Arg 480 Ser INFORMATION FOR SEQ ID NO:1686: SEQUENCE CHARACTERISTICS: LENGTH: 276 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...276 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1686 Asn Lys Pro Asn Lys Gly Ala Val Leu Glu Lys Thr Lys Lys Arg Gin 1 5 10 Leu Leu Gln Lys Lys Thr Lys Lys Arg Ile Lys Gin Lys Arg Leu Pro 25 Gin Lys Lys Ile Lys Gin Lys Thr Arg Gin Arg Leu Lys Arg Lys Ile 40 Glu Val Pro Thr Lys Thr Thr Tyr Leu Leu Leu Glu Glu Ala Gly Ile POT/US 9 6 /091 22 IPEAUS 18 DEC 1996 1228 55 Asn Leu Glu Thr Tyr Glu Lys Ile Leu Ala Leu Leu Gin Lys Ser Asn 70 75 Asn Thr Leu Leu Val Val Gly Glu Glu Ile Tyr Ser His Lys Gin Ala 90 His Asn Ile Ala Lys Met Leu Arg Leu Leu Ala Gin Lys Ser Ala Ile 100 105 110 Lys Leu Ile Leu Ile Pro Pro Ser Ala Asn Ala Leu Gly Ile Ala Ser 115 120 125 Ile Cys Glu Leu Ser Glu Glu Val Phe Glu His Glu Lys Ile Val Gly 130 135 140 Ile Arg Ala Gin Gly Asp Phe Thr Ile Asn Ser Asp Asp Arg Val Phe 145 150 155 160 Gly Lys Asp Ala Val Ser Lys Val Asp Phe Ile Leu Pro Ser Leu Asn 165 170 175 Gin Leu Glu Gly Thr Ile Thr Asn Val Glu Gly Arg Val Leu Pro Leu 180 185 190 Lys Pro Ala Leu Arg Phe Glu Gly Tyr Asp Leu Ser Asp Ile Met Gin 195 200 205 Gly Phe Gly Phe Val Glu Glu Asn Leu Thr Glu Cys Thr His Lys Leu 210 215 220 Pro Thr Glu Ala Gly Phe Lys Ala Leu Glu Phe Asp His Leu Thr Asn 225 230 235 240 Tyr Phe Thr Asn Asp Arg Ala Asn His Arg Gly Tyr Leu Leu Gly Thr 245 250 255 Ser His Phe Glu Asn Ser Ala Lys Glu Ser Lys Pro Gin Asn Ala Ser 260 265 270 Leu Ser Ser Leu 275 INFORMATION FOR SEQ ID NO:1687: SEQUENCE CHARACTERISTICS: LENGTH: 223 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...223 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1687 Gly Gly Phe Met Ala Lys Gin Glu Tyr Lys Gln Leu Pro Lys Arg Ala 1 5 10 Glu Val His Ser Ala Thr Glu Gln Phe Lys Asp Thr Ile Lys Thr Ser 25 Leu Gly Leu Asp Leu Phe Lys Gly Leu Gly Leu Thr Ile Lys Glu Phe 40 Phe Ser Pro Ser Val Thr Ile His Tyr Pro Met Glu Gin Leu Pro Leu 55 Ser Pro Arg Tyr Arg Ala Val His His Leu Gin Arg Leu Leu Asp Ser 70 75 Gly Ser Glu Arg Cys Ile Gly Cys Gly Leu Cys Glu Lys Ile Cys Thr 90. Ser Asn Cys Ile Arg Ile Ile Thr His Lys Gly Glu Asp Asn Arg Lys 100 105 110 PCT/ ,S 9 /0o91 22 IPEA/US 18 EC 1996 1229 Lys Ile Asp Ser Tyr Thr Ile Asn Leu Gly Arg Cys Ile Tyr Cys Gly 115 120 125 Leu Cys Ala Glu Val Cys Pro Glu Leu Ala Ile Val Met Gly Asn Arg 130 135 140 Phe Glu Asn Ala Ser Thr Gln Arg Ser Gln Tyr Gly Ser Lys Ser Glu 145 150 155 160 Phe Leu Thr Ser Glu Gln Asp Ala Lys Asn Cys Ser His Ala Glu Phe 165 170 175 Leu Gly Phe Gly Ala Val Ser Pro Asn Tyr Asn Glu Arg Met Gln Ala 180 185 190 Thr Pro Leu Asp Tyr Val Gln Glu Pro Ser Lys Glu Glu Ser Lys Glu 195 200 205 Glu Ser Pro Thr Ser Pro Glu Ser His Lys Gly Asp Glu Asn Val 210 215 220 INFORMATION FOR SEQ ID NO:1688: SEQUENCE CHARACTERISTICS: LENGTH: 208 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...208 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1688 Ile Met Ser Lys Asn Leu Gln Lys Lys Asn Pro Lys Lys Ser Leu Gin 1 5 10 Gin Ala Gln Lys Ala Ile Arg Glu Met Lys Met Phe Glu Thr Ile Ala 25 Phe Tyr Phe Phe Ala Ile Leu Thr Leu Ser Met Ala Leu Val Val Ile 40 Thr Thr Thr Asn Ile Leu Tyr Ala Ile Thr Ala Leu Ala Ser Ser Met 55 Val Phe Ile Ser Ala Phe Phe Phe Leu Leu Asp Ala Glu Phe Leu Gly 70 75 Val Val Gln Ile Thr Val Tyr Val Gly Ala Val Ile Val Met Tyr Ala 90 Phe Gly Met Met Phe Phe Asn Ser Ala Ala GIu Val Val Glu Arg Lys 100 105 110 Gin Ser Pro Lys Ile Leu Cys Val Leu Ser'Phe Gly Val Ala Leu Leu 115 120 125 Leu Thr Leu Ile Leu Ser Ala Pro Ser Ile Gly Glu Asn Leu Ser Lys 130 135 140 Gin Val Asn Ser Asn Ala Ile Asp Ala Gln Ile Pro Asn Ile Lys Ala 145 150 155 160 Ile Gly Tyr Val Leu Phe Thr Asn Tyr Leu Ile Pro Phe Glu Ala Ala 165 170 175 Ala Leu Met Leu Leu Val Ala Met Val Gly Gly Ile Ala Thr Gly Ile 180 185 190 Gin Lys Ile His Gly Lys Asn His Thr Gln Phe Ile Lys Glu Ser Leu 195 200 205 INFORMATION FOR SEQ ID NO:1689: PCT/US 96/091?2 O i396 1230 SEQUENCE CHARACTERISTICS: LENGTH: 246 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...246 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1689 Met 1 Asn Ile Gly Trp Phe Ala Lys Gly Ala 145 Tyr Val Thr Ile Asn 225 Tyr Lys Gin Gly Leu Tyr Thr Asn Asn Gly 130 Thr Pro Asn His Asn 210 Ala Leu Gin Phe Lys 5 Lys Thr Ile Gly Phe Ala Ser Trp Gly Ala Ile Trp Gly Asn Gin Tyr Tyr His 100 Asp Asn Gly 115 Glu Tyr Asn Phe Asn Leu Asn Gly His 165 Asn Ser Val 180 Thr Gly Thr 195 Ser Asn Ile Asn Ser Val Gin Phe Phe 245 Lys Lys Pro Leu Ser Glu Ser 70 Leu Ser Thr Gly Gly 150 Thr Glu Ala Ser Ile 230 Ser Lys Gly Lys 55 Cys Ile Gin Tyr Gly 135 Ala Asp Val Thr Ala 215 Arg Val 40 Ser Asp Thr Asn Phe 120 Asn Ser Val Gly Leu 200 Tyr Lys Pro 25 Tyr Gin Lys Lys Asn 105 Leu Leu Ser Thr Asn 185 Asn Lys Lys 10 Leu Ala Lys Trp Thr 90 Gin Ser Asp Gly Phe 170 Arg Leu Thr Ile Lys Arg Trp Leu Met Asp Gly Thr Val Cys Val Glu Glu Lys 75 Trp Ala Gly Asp Ile Thr Gly Leu Tyr 125 Ile Glu Leu 140 Asn Ser Phe 155 Ser Ala Gly Val Gly Ser Asn Ala Asn 205 Ser Gln Val 220 Ser Pro Asp His Thr Gly Ala 110 Asn Gly Thr Thr Gly 190 Lys Asn His Leu Ile Arg Gin Asn Asn Tyr Ser Ser Ile 175 Ala Val Val Gin Leu Leu Pro Gin Ala Leu Thr Asn Trp 160 Asn Gly Thr Gly Thr Ile Asn Ser Val Ser Leu Asn Gly Glu 235 240 INFORMATION FOR SEQ ID NO:1690: SEQUENCE CHARACTERISTICS: LENGTH: 400 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: PCIU-6 O/ n9i 1P E ful 1]E 0 196 1231 ORGANISM: HeliCobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .400 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:i690 Val Phe Thr Pro Arg Val Lys Arg Phe Phe Ile 1 Leu Ile Ala Ala Thr Leu Leu Giu Giu 145 Gly Thr Tyr Ile Thr 225 Lys Ile Phe Gin Leu 305 Val1 Ala Leu Leu Ilie 385 Ile Ser Sen Lys Gly Gin Leu Ile 130 Ile Giu Lys Sen Asp 210 Sen Val Ala Giu Lys 290 G iu Thr Gin Asn Leu 370 Gin Leu Leu Leu Asp Ser Thr Giy 115 Tyr Thr Gin Ala Val1 195 Tyr Phe Leu Lys Leu 275 Ile Gly Pro Lys Ser 355 Lys Giy His Ala Ile Lys Phe Gin 100 Ile Ile Arg His Giu 180 0 iu Ser Giu Giy His 260 Lys Ile Ile Gly Ile 340 Lys Asp Asp 5 Giu Leu Phe Ile Gly Phe Ala Aia Leu Leu 165 Leu Lys Sen Thr Giu 245 Leu Pro Ilie Arg Leu 325 Asp Thr Lys Leu Ile Giy Giu Ala 70 Lys Asn Asn Giu Ile 150 Giu Leu Ile Leu Leu 230 Phe Gly Ile Asp Leu 310 Vali Gly Ile Ala Ile 390 Leu Tyr Lys 55 Sen Thr Ala Asp Ala i35S Giu Tyr Asp Lys Val1 215 Ile Asn Leu As n Asp 295 Ala Giu Val1 Ala Gir 371 Let Asn Leu 40 Val Leu Sen His Ile 120 Giy Pro Phe Ser Pro 200 Arg Asn Ala Giu His 280 Sen *Ser Ser *Phe Ser 360 Leu iPhe Thr 25 :ys Leu Lys rhr Ala 105 Asn Ala His Lys Lys 185 Tyr As n G iy Tyr Thr 265 Arg Phe Leu Asn Asp 345 Lys Giu Ala 10 Giu Leu Leu Phe Ser Lys Asn Leu 75 Lys Asn 90 Sen Pro Gin Asn Arg Asn Leu Aia 155 Thn Leu 170 Ang Leu Ala Pro Val GIn Val Trp 235 Asn Ile 250 Giu Arg Leu Gin Asn Gly His Gin 315 Thr Giu 330 Vai Aia Leu Lys Asn Ile Phe Ala Ile Gin Lys Phe Lys Leu Lys 140 Vali Giu Giu Lys Ser 220 Giu Ala Ile Leu Asn 300 Giy Ser Ile Thr Leu 380 Leu Pro Leu Tyr Val1 Leu Sen Asp 125 Giy Val1 Asn Lys Asp 205 Thr Ser Ser Lys Leu 285 Leu Arg Asn Ile Pro 365 Gin Phe Leu Val1 Leu Ile His Val1 Asp Asp Ala Ile Ala 190 Ser Leu Phe Aia Arg 270 Giu Lys Lys Giu Thr 350 Gir Ala Leu is Asn Leu Gin Aia Gin Asn Arg Ile Giu Cys 175 Pro Lys Giu Ile 255 Leu Ala Giy Vai Ala 335 Giy Lys Thn Phe ,iy 3er t'hr Ie Ile Ser 160 Glu Leu Gly Thr 240 Leu Val1 Asn Met Ile 320 Leu Giu Ile Thr Ile 400 Thn Asp Aia 395 Pro Asn Tyr INFORMATION FOR SEQ ID NO:169i: SEQUENCE CHARACTERISTICS: LENGTH: 717 amino acids TYPE: amino acid PCT/US 9 6 0 91 2 IPENUS 18 DEC 1996 1232 TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...717 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1691 Tyr P.
1 Phe V Val Tyr I Trp Gly I Phe Asp I Thr Ile 145 Arg Asp Lys Gly Leu 225 Ser Ile Lys Asn Gin 305 Pro Thr Ile la Leu Lys Ser Leu Arg Gin Ala Tyr Phe Phe Ser Gin Ser Val 1 al Tyr Ile Ala Phe Ile Lys Ala 130 Ile Gln Asp Met Ile 210 Phe Phe His Thr Pro 290 Lys Glu Asp Met Gly I Leu 9 Asn I Asn Cys I Leu Pro 115 Cys Thr Lys Asn Thr 195 Phe Val Tyr Pro Gly 275 Gin STyr 1 Pro p Ala t Ser jeu 2O rhr ?he /al Lys Gly 100 Leu Val Asp Phe Thr 180 Phe Val Phe Asp Lys 260 Glu Ala Ile Prc Ar 34 Se: 5 Tyr I Met I Pro I Lys Val Lys Gly Ala Ile Leu 165 Cys Ala Asp Phe Val 245 Ser Val i Asn Asp o Tyr 325 g Ser 0 r Phe is ,eu Lys Asp 70 /al Phe Thr Leu Lys 150 Asn Tyr Glu Glu Ala 230 Ser Pro Ile Va] Met 31( GlI Tr Ly Gly A Ile S 4 Thr T 55 Ile C His Gly I Met Pro .135 Gly Asn Phe Gin Glu 215 Leu Ile Tyr Leu L Leu 295 t Asn 0 y Thr p Ala s Arg r Lys 375 la er 0 'hr ;lu Arg 'he Ile 120 Asn Glu Arg Asn Leu 200 Asp Leu Ala Tyr Asp 280 Lys Asp Lys Asx Ph< 361 Me 10 Ser Ile Phe Asp L 25 Leu Met Pro Phe V 4 Glu Thr Ser His G Cys Phe Lys Ile P 75 Leu Gly Val Gin P 90 Pro Lys Leu Arg 105 Val Ala Pro Pro C Leu Leu Thr Leu I 140 Leu Arg Asp Lys 155 Ile Leu Ile Phe 2 170 Pro Phe Asp Lys 185 Arg His Val Lys His Trp Val Ser 220 Gin Val Val Thr 235 Pro Ala Asn Asp 250 Lys Gin Leu Tyr 265 Pro Gin Thr Asn Leu Phe Leu Asn 300 Glu Lys Asn Tyr 315 Gly Ala Leu Asp 330 i Thr Pro Asp Asp 345 e Met Tyr Val Tyr 0 t Ser Phe Asp Tyr eu 'al !ly ?he >he Asn Gly 125 ?ro Thr Asn Arg Ala 205 Lys Lys Tyr Gin Ala 285 Gin Asp Gl Gi1 Ly- 36.
Gli Lys P Ala T Tyr A Ser L Asp A 9 Val C 110 Ala G Asn S Ala G Pro Ile 190 Val C Ala I Gly Ala His 270 Pro Val Pro Ile i Phe 350 s Asp u Glu he hr la ys .sn ys ly er ;ly 'yr Val Gly Lys His Pro 255 Asp Met Ala Arg Ili 33 Gil Pr Le Glu Ile Arg Glu Gly Tyr Lys Cys Tyr 160 Gly Glu Asp Glu Ser 240 Leu Lys Lys Asp Glu 320 e Arg y Ser o Lys u Arg e Gly 400 355 Val Arg Glu Ala Thr Se 370 Thr 385 Gly Asn Ile Ser Tyr lie Val lie Gin lie Asp Ii 936ui I PE iS cf9 1233 Thr Leu Ala Pro Asp 465 Leu Glu Ser Ser Met 545 Ala Leu Arg Asn Glu 625 Pro Glu Asn Ser Glu 705 Leu Met Asp Ala 450 Tyr Lys Asp Lys Ser 530 Asn Thr Leu Val Gin 610 Asn Gin Ser His Met 690 Glu Ser Val Glu 435 Leu Ala Gly Ala Asn 515 Tyr Ile Pro Lys Glu 595 Asn Glu Glu Pro Asn 675 Glu Ser Ser Lys 420 Phe Cys Met Val Glu 500 Tyr Ser Asn Leu Arg 580 Glu Lys Ser Leu Ile 650 Glu Glu Glu Leu 405 Glu Val Arg Ile Val 485 Ile Ser His Ser Lys 565 Ala Pro Ala Asn Glu 645 Thr Ile Lys Gin Val Ser Arg Ser Arg 470 His Val Thr Glu Asp 550 Leu Asn Ile Asp Glu 630 Asn Leu Asp Arg Glu 710 Ala Lys Gly 440 Asn Tyr Asn Lys Lys 520 Arg Val Ala Pro Pro 600 Glu Asn Asn Asn Ile 680 Leu Thr Leu 410 Glu Leu Val Ser Val 490 Val Gin Leu Val Tyr 570 Asp Thr Ser Asn Lys 650 Asn Lys Lys Ser Glu Glu Pro Pro Asp 475 Phe Gly Leu Leu Ile 555 Trp Leu Glu Asn Glu 635 Glu Glu Lys Lys Thr 715 Ser Ile Arg Ile Phe Leu 445 Leu Phe 460 Asp Asp Lys Met Glu Phe Val Phe 525 Thr Ala 540 Val Thr Phe Lys Glu Val Ile Glu 605 Lys Gly 620 Asn Asn Ser Glu Asn Ile Pro Leu 685 Met Gin 700 Gin Ser Ala Lys 415 Phe Ile 430 Leu Glu Ile Thr Leu Lys Asn Ser 495 Thr Arg 510 Gly Gly Gin Asp Gly Ala Asp Lys 575 Glu Arg 590 Thr Thr Glu Lys Pro Thr Lys Asp "655 Glu Gin 670 Ser Glu Gin Ser INFORMATION FOR SEQ ID NO:1692: SEQUENCE CHARACTERISTICS: LENGTH: 2440 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION 1...2440 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1692 Tyr Asn His Pro Asn Leu Ser Val Ala Asp Leu Glu Leu Glu Gin Gin 1 5 10 Asn Leu Gly Glu Gln Asn Gly Lys Glu Arg Thr Asn Arg Ala Asp Glu PO/US 96/091z9 IfrUtj~18 DEC 1996 1234 Pro Asn Gly Giu Pro Arg Leu Ser His Gly Thr Arg Giu Ser His Asp Gly Val 115 Ser Ser Pro 130 Gly Asp Asn 145 Pro Ser His Arg Giu Gin Gin Met Gly 195 Ser Asp Asn 210 Asp Lys Ser 225 Ser Giu Arg Leu Pro Ala Gly Leu Arg 275 Ser Asn Leu 290 Thr Ile Ala 305 Gin Asn Asn Lys Asp Pro Ser Pro Lys 355 Ile Giu Thr 370 Gin Ala Ile 385 Thr Gin Giu Gin Giu Gin Giu Gin Thr 435 Gin Thr Thr 450 Ala Pro Thr 465 Leu Asn Pro Gly Ala Lys Lys Giu Leu 515 Thr Leu Lys Thr Arg Ala Giy Ile Pro Gin Giu Gly Gin Gly Arg 100 Ser Ala Pro Gin Pro 180 Ser Giu Pro Tyr Gin 260 Asp Asp Ser Asp Thr 340 Lys Thr Asp Ser Thr 420 Thr Gin Thr Lys Thr 500 Gin Gin Asp Val1 Giu Ala Ser Ser Gin 165 Giy Leu Leu Arg Gly 245 Ser Leu As n Giu Pro 325 Thr Val1 Asn Leu Lys 405 Ala Gin Giu Ile Ile 485 Arg Ala Gin Pro 70 Tyr Arg Arg Arg Asp 150 Asn Gin Phe Asp Gin 230 Ile Arg Giu Leu Pro 310 Leu Lys Leu Giu Asn 390 Ile Gin G lu Gin Lys 470 Asp Tyr Lys Giu 55 Ser Arg Asp Ala Met 135 Giu Ser Thr Pro Arg 215 Asn Ala Leu Giu Giu 295 Asp Lys Ile Giu Thr 375 Ala Thr Giu Gin Thr 455 Gin Phe Lys Gin 40 Gly Met Leu Phe Ser Ser Arg Ile 105 Asp Ala 120 Glu Asn Arg Giy Ser Arg Gly Arg 185 Thr Asp 200 Arg Ser Gly Ser Gin Gly His His 265 Asn Arg 280 Ser Leu Phe Arg Asp Ser Phe Tyr 345 Ile Leu 360 Leu Asn Ile Ser Asp Asn Gin Thr 425 Thr Thr 440 Thr Gin Giu Thr Lys Pro Ala Asn 505 Giu Ile 520 Giu Ile Asp 90 His Arg Gly Ile Asp 170 Leu His Asp Ala Ser 250 Ala Asp Leu Ser Ile 330 Asp Giu Ala Asn Ser 410 Thr Gin Giu Pro Ser 490 Ile Leu Arg Giu 75 Gin Giu Ala Ala Pro 155 Leu Arg Giu Lys Asn 235 Ser Gly Gin As n Arg 315 Val1 Lys As n Phe Ser 395 Val1 Gin Giu Gin Ile 475 Giu Lys Lys Phe Ile Ser Ser Gin His Asn Arg 140 Gin Gly Leu Asn Ala 220 Gin Asn Leu Giu Ala 300 Leu Gly Phe Arg Asn 380 Val1 Giu Giu Gin Asp 460 Thr Clu Ala Gly Ser 540 His Ser Arg Ala Val1 Ser 125 Ser Thr Leu Phe Gin 205 Asn Giu Gin Ser Gly 285 Ile Leu Ala Gin Leu 365 Val1 Gly Leu Gin Thr 445 Thr Pro Val Ile Asp 525 Gly Arg Asp Giu Vai Ser 110 Asn Giu Pro Ser Asp 190 Arg Giu Ser Ser Ala 270 Arg Arg Giu Gin Leu 350 Lys Leu Leu Asn Thr 430 Thr Gin Ala Leu Giu 510 Tyr Trp Arg Giu Gin Ser Arg Gly Giu Gin Leu 175 His Lys Asn Ala Val1 255 Gin Leu Asn Ala Leu 335 Lys Lys Asp Asn Asn 415 Thr Gin Giu Ile Ile 495 Leu Tyr Gly Ser Asp Gly Glu Gly Ala Lys Ser 160 Ser Gly Arg Gly Arg 240 Leu Asn Leu Asn Ile 320 Leu Ile Ser Ser Pro 400 Ala Gin Giu Asn Pro 480 Lys Leu Ala Gly Giu Gin Giu Ile Leu Ala Gin PCT/US 96/09122 iPEA/US 18 DEC 1996 1235 Leu Glu Ser Tyr Phe Lys Ala Gin His 545 Leu Asn Ala I Ala Arg Asp P Gin Gly Leu 595 Ile Phe Giu 1 610 Ser Asp Lys 625 Ala Asn Leu S Ala Leu Glu I Asn Pro Pro 675 Leu Ser Asn 690 Giu Leu Lys 705 Met Asp Ala Thr Phe Leu Gly Ala Glu 755 Lys Ala Thr 770 Ile Leu Asn 785 Arg Phe Asp Val Ala Asn Glu Lys Ile 835 Ile Ile Lys 850 Asn Glu Gin 865 Leu Gly His Gly Glu Gin Leu Asp Leu 915 Asp Val Tyr 930 Ile Asp Ser 945 Asn Leu Giu Leu Glu Gin Asn Ser Lys 995 Asp Ala Leu 1010 Asp Leu Glu 1025 Glu Phe Val eu 1 la 80 Asp C 'ro Asn ;er Asn 660 Tyr Glu Asp Lys iy 740 Val Asn Ser Ser His 820 Asp Asp Thr Leu Ile 900 Ser Gin Ser Arg Asn 980 Val Leu Tyr ;in ;er Tyr Lys 545 Tyr ;ly Ser Asp Asn 725 Ala Thr Gln Leu Phe 805 Phe Thr Phe Leu Ser 885 Tyr Gin Tyr Asr Arc 965 As Gl Thr Lys Asp Gu P 5 Tyr Thr Pro Lys L 585 Leu Gly Phe Asn A 600 Leu Gly Tht Gly L 615 Arg Phe Ile Gly T 630 Phe Leu Tyr Pro P 6 Gin Phe Tyr Gin G 665 Asn His Lys Ile 680 Ile His Asn Tyr 1 695 Gly Ile Gly Ala 1 710 Pro Lys Met Arg C Ile Arg Leu Pro 1 745 Ser Asp Ile Val 760 Ser Phe Thr Lys 775 Asp Asp Asp Thr 790 Ile Pro Ser Asp Gly Phe Lys Gin 825 Ala Asn Phe Gly 840 Ile Asp Lys Val 855 Asn Giu Tyr Phe 870 Leu Glu Lys Thr Lys Tyr Asp Leu 905 Ala Leu Lys Gin 920 His Lys Thr Thr 935 Giu Arg Tyr Gin 950 Glu Leu Val Lys i Giu Met Gly Ile 985 i Asp Ser Arg Leu 1000 p Leu Thr Ser Ala 1015 u Asn Lys Arg Ala 1030 s Phe Gly Tyr Leu he 70 eu sn ys hr sn 50 lu Tyr Phe Phe lu 730 Asn ?he Ala Leu 810 Glu Tyr Gly Ile Arg 890 Gir Ala Leut Gl Tr 97 Ph Ly Gl Ly Pro Giu 555 Arg Arg Val Ile Asp Asn Phe Ile 620 Glu Leu 635 Gin Val Tyr Asp Ser Ser Leu Gly 700 Val Val 715 His Ile Ser Vc Phe Lys Met Pro 780 Phe Ala 795 Leu Lys Lys Leu Ser Thr Lys Asn 860 His His 875 Tyr Arg Ala Leu Ile Glu Lys Thi 94C .1 Val Gir 955 p Asp Asr 0 Leu Lys s Ala Tyi u Leu Asi Glu Phe r Ala Tyr L Asp Ser I 590 His Pro 605 Ala His I Asp Pro Ile Gin I Ala Phe 670 Asn Asp 685 Lys Ala Ser Ser Ala Lys Phe Lys 750 Lys Gly' 765 Tyr Tyr Leu Gln* Ile Val Gin Arg 830 Gin Asp 845 Ser Ile Pro Glu Phe Giu Glu Asp 910 Lys Leu 925 Asp Val Lys Leu Leu Tyr Pro Thr 990 c Phe Lys 1005 a Pro Leu jys eu 575 le Lys Ala le Asn 655 tal Lys Ile Trp Asn 735 Ala Val Asp ksn Asn 815 Trp Tyr Asn Asn Thr 895 Glu Pro Lev I lE Ph 97 Ly Ii Se Giu 560 Ser Tyr Lys Pro Ser 640 Thr Gly Giu Lys Phe 720 Ala Thr Giu Lys Asn 800 Ala Tyr Lys Leu Ile 880 Asn Ser Lys Ile Lys 960 e Gin Ile Lys r Ser Asn As Leu GI Lys Ly s 1020 Leu Asn Leu Val 45 1035 Asn Glu Asn Lys 1050 Lys Val Leu Gly Tyr Asp 1040 Arg Lys 1055 Glu Lys Asp Ile Arg Gin Asp Leu Tyr Gly Ala PCT/U 10 'o/U 9 2.
2 IPEMUS 18 DEC1996 1236 1060 1065 1070 Asp Phe Glu Lys Glu Ile Thr Pro Arg Ser Ala Lys Met Gin Asn Ile 1075 1080 1085 Glu Pro Arg Gln Ala Gln Ala Lys Lys Ala Gln Ile Phe Phe Giu Arg 1090 1095 1100 Thr Leu Asn Pro Lys Lys Glu Leu Ile Ile Thr Asn Ala Lys Glu Ala 1105 1110 1115 1120 Leu Ile Ala Ser Ile Asn Gln Lys Gly Gly Leu Asp Leu His Phe Ile 1125 1130 1135 Arg Asp His Phe Thr Thr Gln Ser Leu Glu Thr Thr Ile Lys Glu Leu 1140 1145 1150 Leu Glu Gln Lys Leu Ile Tyr Lys Asp His Lys Asp Asn Gly Gly Tyr 1155 1160 1165 Ile Leu Ala Asn Asp Tyr Leu Ser Gly Asn Val Lys Arg Lys Leu Lys 1170 1175 1180 Glu Val Lys Glu Ala Ile Asn Gln Gly Val Glu Gly Leu Glu Ala Asn 1185 1190 1195 1200 Val Lys Asp Leu Glu Leu Ile Ile Pro Lys Asp Leu Lys Ala Thr Glu 1205 1210 1215 Ile Met Ala Asn Ile Asn Ser Pro Trp Ile Pro Thr Gln Tyr Leu Glu 1220 1225 1230 Glu Phe Leu Met Glu Leu Ser Ala Asn His Tyr Glu Lys Gln Tyr Gly 1235 1240 1245 Asp Lys Met Thr Asp Tyr Gln Leu Ser Asn Leu Lys Glu Asp Ile Lys 1250 1255 1260 Ile Glu His Leu Ser Gly Ala Tyr Glu Val Phe Val Arg Asn Asn Glu 1265 1270 1275 1280 Leu Asn Glu Leu Tyr Gly Ile Arg His Lys Asp Lys Pro His Ser Tyr 1285 1290 1295 Lys Val Pro Phe Glu Ser Leu Leu Asn Lys Val Leu Asn Asn Lys Asp 1300 1305 1310w Leu Ser Val Lys Tyr Ala Gln Val Asp Pro Asn Asp Pro Lys Lys Glu 1315 1320 1325 Ile Phe Ile Thr Asp Glu Glu Gln Ser Asn Leu Ala Arg Gln Lys Ala 1330 1335 1340 Glu Glu Leu Lys Glu Ala Phe Lys Asp Trp Ile Tyr Lys Asp Tyr Ser 1345 1350 1355 1360 Arg Arg Thr His Leu Glu Gln Ile Tyr Asn Asp Thr Phe Asn Asn Phe 1365 1370 1375 Val Leu Lys Thr Tyr Asp Gly Ser Gln Leu Glu Leu Glu Gly Phe Asn 1380 1385 1390 Tyr His Ile Ser Leu Arg Pro His Gin Lys Asn Ala Ile Phe Arg Thr 1395 1400 1405 Ile Gln Asp Arg Ala Val Cys Leu Asp His Gln Val Gly Ala Gly Lys 1410 1415 1420 Thr Leu Cys Ala Ile Ala Ser Cys Met Glu Gln Lys Arg Met Gly Leu 1425 1430 1435 1440 Val Asn Lys Thr Leu Ile Ala Val Pro Asn His Leu Thr Lys Gln Trp 1445 1450 1455 Gly Asp G1u Phe Tyr Lys Ala Tyr Pro Asn Ala Asn Val Leu Val Val 1460 1465 1470 Asp Ser Lys Asp Thr Thr Glu Lys Glu Arg Glu Leu Leu Phe Asn Gin 1475 1480 1485 Ile Ala Asn Asn Asn Tyr Asp Ala Val Val Ile Ala His Thr His Leu 1490 1495 1500 Glu Leu Leu Ser Asn Pro Arg Gly Ile Ile Glu Glu Leu Lys Glu Glu 1505 1510 1515 1520 Glu Leu Val Asn Ala Glu Lys Asn Phe Glu Arg Gln Glu Leu Ala Tyr 1525 1530 1535 Lys Asn Asn Pro Arg Glu Thr Lys Lys Pro Asn Glu Arg Ala Phe Lys 1540 1545 1550 Asn Lys Leu Asp Lys Ile Arg Ala Lys Tyr Asp Ala Ile Leu Glu Lys 1555 1560 1565 Gin Gly Ser His Ile Asp Ile Ser Gln Met Gly Ile Asp Asn Leu Ile 1570 1575 1580 PCT/US 96/09122 1237 Val Asp Glu Ala His Leu Phe Lys Asn Leu Ala Phe Glu Thr Ser Met 1585 1590 1595 1600 Glu Lys Ile Ala Gly Leu Gly Asn Gin Gin Gly Ser Asn Arg Ala Arg 1605 1610 1615 Asp Leu Phe Ile Lys Thr Arg Tyr Leu His Gin Asn Asp Lys Lys Ile 1620 1625 1630 Met Phe Leu Thr Gly Thr Pro Ile Ala Asn Ser Leu Ser Glu Met Tyr 1635 1640 1645 His Leu Gln Arg Tyr Leu Thr Pro Asp Val Leu Lys Glu Arg Gly Leu 1650 1655 1660 Glu Phe Phe Asp Asp Trp Ala Lys Thr Tyr Gly Glu Val Val Asn Asp 1665 1670 1675 1680 Phe Glu Leu Asp Thr Ser Ala Gln Ser Tyr Lys Met Val Asn Arg Phe 1685 1690 1695 Ser Lys Phe Ser Asp Val Gln Gly Leu Ser Thr Met Tyr Arg Ala Phe 1700 1705 1710 Ala Asp Ile Val Ser Asn Asp Asp Ile Leu Lys His Asn Pro His Phe 1715 1720 1725 Val Pro Lys Val Tyr Gly Asp Lys Pro Ile Asn Val Val Val Lys Arg 1730 1735 1740 Ser Glu Glu Val Ala Gln Phe Ile Gly Val Ala Leu Glu Asn Gly Lys 1745 1750 1755 1760 Tyr Asn Glu Gly Ser Ile Ile Asp Arg Met Gln Lys Cys Glu Gly Lys 1765 1770 1775 Lys Ser Gln Lys Gly Gln Asp Asn Ile Leu Ser Cys Thr Thr Asp Ala 1780 1785 1790 Arg Lys Val Ala Leu Asp Tyr Arg Leu Ile Asp Pro Asn Ala Lys Val 1795 1800 1805 Glu Lys Glu Phe Ser Lys Ser Tyr Ala Met Ala Lys Asn Ile Tyr Glu 1810 1815 1820 Asn Tyr Leu Glu Thr His Ala Thr Lys Gly Thr Gln Leu Gly Phe Ile 1825 1830 1835 1840 Gly Leu Ser Thr Pro Lys Thr His Ser Gln Lys Val Ser Leu GIu Ala 1845 1850 1855 Leu Asp Asn Ala His Glu Thr Glu Asn Lys Asn Pro Leu Asp Lys Ala 1860 1865 1870 Gin Glu Leu Leu Glu Ser Leu Ser Ser Tyr Asp Glu Lys Gly Asn Leu 1875 1880 1885 Ile Ala Pro Ser Lys Lys Glu Leu Glu Asn Glu Leu Lys Glu Lys Glu 1890 1895 1900 Ala Lys Ser Val Asn Leu Asp Glu Glu Ile Ala Lys Gly Cys Ser Phe 1905 1910 1915 1920 Asp Val Tyr Ser Asp Val Leu Arg His Leu Val Gln Met Gly Ile Pro 1925 1930 1935 Gin Asn Glu Ile Ala Phe Ile His Asp Ala Lys Thr Glu Glu Gln Lys 1940 1945 1950 Gin Asp Leu Phe Lys Lys Leu Asn Arg Gly Gly Val Arg Val Leu Leu 1955 1960 1965 Gly Ser Pro Ala Lys Met Gly Val Gly Thr Asn Val Gln Glu Arg Leu 1970 1975 1980 Val Ala Met His Glu Leu Asp Cys Pro Trp Arg Pro Asp Glu Leu Leu 1985 1990 1995 2000 Gin Met Glu Gly Arg Gly Ile Arg Gln Gly Asn Ile Leu His Gln Asn 2005 2010 2015 Asp Pro Glu Asn Phe Arg Met Lys Ile Tyr Arg Tyr Ala Thr Glu Lys 2020 2025 2030 Thr Tyr Asp Ser Arg Met Trp Gln Ile Ile Glu Thr Lys Ser Lys Gly 2035 2040 2045 Ile Glu Gln Phe Arg Asn Ala His Lys Leu Gly Leu Asn Glu Leu Glu 2050 2055 2060 Asp Phe Asn Met Gly Ser Ser Asn Ala Ser Glu Met Lys Ala Glu Ala 2065 2070 2075 2080 Thr Gly Asn Pro Leu Ile Ile Glu Glu Val Lys Leu Arg Ala Glu Ile 2085 2090 2095 Lys Ser Glu Glu Ser Lys Tyr Lys Ala Phe Asn Lys Glu His Tyr Phe POT/US 96/091 2.
IPENUS 18 DC i996 1238 2100 2105 211.0 Asn Glu GIu Ser Leu Lys Asn Asn Ala Ser Lys Leu Asp Tyr Leu Lys 2115 2120 2125 Gin Glu Leu Lys Asp Leu Glu Thr Leu Gin Arg Ser Val Ile Ile Pro 2130 2135 2140 Thr His Thr Glu Ile Lys Leu Tyr Asp Leu Lys Asn Glu Glu Ser Lys 2145 2150 2155 2160 Asp Tyr Glu Leu Ile Lys Val Lys Glu Val Glu Pro Leu Lys Glu Asn 2165 2170 2175 Ala Ser Met Ser Glu Glu Leu Thr His Lys Lys Leu Lys Glu Gin Asn 2180 2185 2190 Lys Gin Ile Ala Glu Gin Asn Lys Glu Lys Leu Asp Ala Ile Lys Lys 2195 2200 2205 Gin Phe Ala Ser Asn Leu Asn Thr Leu Phe Val Asn Glu Glu Glu Asp 2210 2215 2220 Tyr Lys Leu Leu Glu Tyr Lys Gly Phe Val Val Asn Ala Tyr Lys Thr 2225 2230 2235 2240 Lys Tyr Gin Val Glu Phe Ser Leu Ser Pro Lys Asp Asn Pro Asn Ile 2245 2250 2255 Ala Tyr Ser Pro Ser Asn Met Val Tyr Lys Asn Asp Thr Ile Asn Met 2260 2265 2270 Phe Ser Ser Tyr Asn Phe Cys Ala Glu Ile Lys Phe Asp Gly Phe Leu 2275 2280 2285 Lys Arg Leu Asp Asn Ala Ile Thr Lys Leu Pro Glu Lys Ile Lys Glu 2290 2295 2300 Leu Glu Asn Ser Ile Glu Ile Thr Lys Lys Asn Ile Ala Lys Tyr Thr 2305 2310 2315 2320 Arg Leu Val Giu Gin Lys Pro Ser Tyr Pro Arg Leu Glu Tyr Leu Gin 2325 2330 2335 Ala Leu Lys Trp Asp His Lys Thr Leu Ile Asp Asp Leu Ala Lys Met 2340 2345 2350 Ser Lys Asp Arg Asn Tyr Lys Pro Ala Phe Asn Pro Lys Ser lys Glu 2355 2360 2365 Val Leu Lys Asn Leu Asn Ala Glu Lys Arg Ala Ser Leu Glu Asn Glu 2370 2375 2380 Arg Glu Glu Gin Gly Val Lys Gly Asn Thr Lys Ser His Asp Glu Ile 2385 2390 2395 2400 Glu Pro Ala Thr Glu Gin Val Ile Glu Lys Glu Ile Glu Lys Gly Asp 2405 2410 2415 Glu Ile Ala Asn Asn Val Asp Tyr Tyr Glu Asn Glu Gin Glu Val Glu 2420 2425 2430 Ile Thr Lys Ser Met Gly Arg Arg 2435 2440 INFORMATION FOR SEQ ID NO:1693: SEQUENCE CHARACTERISTICS: LENGTH: 425 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...425 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1693 °T7 PCTuib 9 6 /091 2 2 IPENUS 18 DEC 996 1239 Arg Glu Gly Ala Met Asn Phe .ie Asp Thr Leu Met Gly Met Phe Val 1 5 10 Glu Pro Ser Gln Lys Val Ala Lys Ser Leu Ala Glu His Val Glv Ser 25 Phe Phe His Ala Gln Leu Ile Leu Asn Thr Ile Ile Thr Ile Leu Phe 40 Met Ile Trp Ala Tyr Lys Arg Val Lys Glu Gly Asp Met Phe Glu Phe 55 Lys Thr Ala Met Gly Val Val Val Phe Ile Ala Phe Val Gly Phe Ile 70 75 Asn Trp Gly Ile Lys Asn Pro Asn Asp Phe Asn Thr Tyr Phe Ile Asn 90 Thr Ile Phe Tyr Pro Ser Glu Lys Leu Ala Ile Leu Ile Ala Gln Ser 100 105 110 Leu Asn Asp Gly Leu Glu Ile Pro Thr Asn Thr Asn Leu Ser Pro Ser 115 120 125 Glu Ile Phe Ser Ile Gly Asn Leu Ala Ser Ser Ala Tyr Ala Met Ile 130 135 140 Val Asn Leu Trp Asp Asn Ala Phe Asp Gly Ile Asn Met Phe Asn Trp 145 150 155 160 Leu Thr Met Ile Pro Lys Ile Ile Met Phe Phe Leu Val Ile Leu Gly 165 170 175 Glu Leu Leu Phe Leu Gly Leu Leu Leu Ile Ile Val Leu Leu Val Thr 180 185 190 Ala Glu Ile Phe Met Trp Ser Ala Leu Gly Leu Ile Val Leu Pro Leu 195 200 205 Gly Leu Ile Pro Gln Thr Lys Gly Met Leu Phe Ser Tyr Leu Lys Lys 210 215 220 Leu Ile Ser Leu Thr Leu Tyr Lys Pro Cys Met Met Leu Val Ala Phe 225 230 235 240 Phe Asn Tyr Gly Ile Ile Tyr Lys Val Asn Thr Leu Ile Pro Thr Lys 245 250 -255 His Glu Val Thr Gln Gly Phe Tyr Gly Asn Ala Asp Lys Met Ala Asn 260 265 270 Glu Gly Lys Ile Ile Asp Val Phe Gly Asn Val Leu Lys Gly Asp Trp 275 280 285 Asn Ser Tyr Ile Ala His Ser Ser Ile Val Gly Phe Leu Thr Ile Ile 290 295 300 Val Leu Gly Ser Val Ile Cys Phe Phe Leu Val Lys Arg Val Pro Asp 305 310 315 320 Phe Ile Asn Asn Ile Phe Gly Thr Ser Gly Gly Val Gly Ala Val Thr 325 330 335 Glu Met Met Gln Lys Ile Gly Met Thr Ile Gly Gly Ala Val Phe Gly 340 345 350 Gly Ser Ala Val Met Val Ala Asn Gln Val Lys Gln Ala Tyr Gln Ser 355 360 365 Ala Gly Gly Gly Leu Ala Gly Leu Gln Ala Gly Ala Lys Ala Phe Gly 370 375 380 Leu Gly Ala Ile Ser Gly Gly Ala Ser Ala Met Ala Asn His Arg Ser 385 390 395 400 Val Lys Ala Gly Val Lys His Phe Val Ala Ser Val Lys Ser Gly Phe 405 410 415 Gly Phe Asp Asn Asp Lys Asn Asn Lys 420 425 INFORMATION FOR SEQ ID NO:1694: SEQUENCE CHARACTERISTICS: LENGTH: 442 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein PCT/US 96/09122 -0i11i 996 1240 (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...442 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1694 Lys Glu Gin Gin Met Ala Tyr Lys Pro Asn Lys Lys 1.
1 Leu P Ala I Glu 1 Ile E Arg Gly C Phe Asp Thr 145 Thr Ile Arg Ser Asn 225 Lys Gin Asp Lys Gin 305 Gin Leu Tyr Pro Lys 385 Ala rg Thr Pro er Val Glu Glu Arg 130 Asn His Val Thr Ala 210 Asn Leu Gin Asn Leu 290 Phe Ser Ser Glu Phe 37 Gli Ly Glu C 2 Asn A Leu I Arg I Tyr I Ile I Arg 2 115 Asn Ser His Lys Lys 195 Glu Glu Glu Leu Ala 275 Lys Phe Ala Leu Ser 355 Lys i Arg s Giu 1n 0 sn Pro Asp Lys Lys 100 Arg Arg Leu Asn Glu 180 Asp Tyr Asn Phe Leu 260 Asn Glu Phe Ile Glu 340 Va G1 Ty Gl Ly 42 5 Pro A Pro V Tyr V Pro I 7 Asp A Glu S Ile T Glu P Lys C Glu 9 165 Tyr Gly Phe Thr Glu 245 Ser Phe Asn Asn Gin 325 Glu L Tyr u Ile r Asp e Gly 405 sn al al le 0 sn er hr he lu 150 Thr Asp Gly Lys Lys 230 Leu Ala Ala His Asn 310 Giu Ile Val Leu Lys 39( As Leu P Glu G 4 Val L 55 Glu T Ser L Ser I Lys I Phe 135 Leu His His Leu Leu 215 Leu Ala Thr Trp Leu 295 Gly Asn Ala Asn Arg 375 Leu i Glu he lu 0 ys rp ys rg Arg .20 le .ys Lys Leu Val 200 Tyr Asn Lys Asn Lys 280 Ser Ser Arg Gin Gly 360 Asp Va Ar Ser I 25 Ser A Thr G Ala L Giu A 9 Val T 105 Tyr A Lys G Glu G Lys P Lys 185 Arg Asn Thr Glu Tyr 265 Met Ala Ile Asp Ala 345 Asp Thr l Ser g Gin u Thr 425 0 le L sp L in I ys T 7 sp V 0 yr G sp L lu I 1n C la 1 .70 Asp Glu Lys Asn Vali 250 Tyr His Asn Leu Tyr 330 Lys Gly Asn Leu Asn 410 eu A ys A le A 6 yr L 5 'al A 1 u A eu I 1ie C ly I 155 Leu C Ile Ile Leu Asp 235 His Ser Arg Asn Gly 315 Ser Ile Asn Asn Ser 395 Ser sp la s n 0 eu s n la le lu jeu Glu Tyr Ile Pro 220 Asn Ile Trp Leu Ala 300 Trp Let G 1 Ly Ph 38 Al Se Lys L Lys G 3 Asn L Lys A Ser P Phe P Asn L 1 Asp 125 Ile I Glu Asn Gin Pro 205 Phe Glu Leu Ile Ile 285 Asn Thr Arg .u Leu s Arg 365 e Giu 0 a Ala r Ala eu ly 0 ys la he he ys Arg Leu Ile ly Glu 190 Ser Glu G1u Ile Asp 270 Asr Lys Ly Se Gi1 35 GIl Ly
I
As Lys G Asp V Ile G Ser M Glu L 8 Ala A Glu G Asn I Thr H Gin L a Asn G 175 Val C Ile E Ser Val Leu 255 Lys G1u Ile s Glu r Ala 335 n Lys 0 u Ile s Ala e Ile n Asn 415 n Ile lu al in et ys 0 sn ly le is eu lu lu Ser Ile Lys 240 Glu Asp Asn Lys Glu 320 Leu Tyr Lys Tyr Gin 400 Asn Ile Asn Pro Ile s 0 Asn Thr Ile Gl Asn Thr Ser Asn As 430 0.QHFFT PCT/US 9 6 0 91 !PEA/US EC996 1241 Gin Asn Asn Asp Asn Ile Ile Ile Gln Ile 435 440 INFORMATION FOR SEQ ID NO:1695: SEQUENCE CHARACTERISTICS: LENGTH: 70 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...70 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1695 Ile Lys His Tyr Lys Gln Tyr Gly Thr Gly Leu His Leu Phe Arg His 1 5 10 Ser Phe Ala Thr Leu Ile Tyr Gln Glu Thr Gln Asp Leu Val Leu Thr 25 Ser Arg Ala Leu Gly His Ser Ser Leu Leu Ser Thr Lys Ile Tyr Ile 40 His Thr Thr Gln Glu His Asn Lys Lys Val Ala Leu Val Phe.Asp Ser 55 Leu Ile Glu Asn Lys Lys INFORMATION FOR SEQ ID NO:1696: SEQUENCE CHARACTERISTICS: LENGTH: 149 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...149 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1696 Lys Lys Arg Lys Tyr Met Arg Phe Arg Arg Val Lys Lys His Lys Asn 1 5 10 Lys His Asn Lys Glu His Thr Ser Met Asp Leu Gln Gln Ile Asp Glu 25 Leu Glu Lys Lys Phe Glu Glu Gln GIu Glu Gln Ala Gln Asp Thr Pro 40 Leu Lys Gln Glu Pro Ser Thr Lys Glu Val Lys Ile Pro Lys Lys Arg 55 Gly Arg Lys Lys Ser Leu Leu Asp Glu Asp Lys Lys Lys Ser Phe Asn
M
POUS 96/09122 1PEN/US ioL 996 1242 Ile Giu Leu Leu Asn 145 70 75 Phe Ser Pro Cys Val Ile Lys Giu Leu Asn Giu 90 Gly Ser Phe Lys Glu Thr Arg Ser Thr Phe Ile 100 105 Arg His Leu Lys His Arg Lys Asn Thr Gin Giu 115 120 125 Gin Leu Giu Arg Leu Gin Asri Lys Giu Lys Gly 135 140 Giu Leu Giu Phe Leu Leu Giu Giu Aia 110 Gin Lys Leu Asn Asn Glu INFORMATION FOR SEQ ID NO:1697: SEQUENCE CHARACTERISTICS: LENGTH: 373 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION I1.. .373 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1697 Leu Asn Thr Asp Lys Ile Thr Lys Tyr Leu Ile Ile 1 Leu Lys Thr Ala His Gly Gin Lys Giu 145 Arg Pro Gly Ser Giu 225 Lys Lys Gly Sen so Lys Asn Ser Giu Gin 130 Leu Gin Asn Ala Arg 210 Gly Lys Leu Ile Leu Pro Ile Gin Tyr 115 Ala Ala Lys Lys Giu 195 Giu Lys Asp Tyr Lys Leu Leu Lys Tyr 100 Arg Leu Lys Phe Lys 180 Ser As n Ile Phe 5 Val1 Met Ala Leu Glu Leu Giu Asn Lys Met 165 Gin Phe Thr Leu Glu 245 Ile Ile Gly Ser 70 Asp Asn Lys Leu Ile 150 Ala Leu Ile Tyr Ala 230 Glu Ile Leu 40 Leu Giu Leu Gly Phe 120 Asn Giu Giu Thr Asp 200 Ala Gly Thr Ser 25 Lys Leu Asp Thr Trp 105 Giu Lys Ile Met Met 185 Trp Leu Glu Tyr 10 Giu Gly G ly Leu Ser 90 Asn Cys Giu Lys Lys 170 Leu His Gly Arg Asp 250 Ile Leu Ala Leu 75 Cys Leu Val1 Asp Glu 155 Glu Glu Giu Ile Ser 235 Thr Ile Lys Lys Ala Arg Ala Lys Giu 125 Lys Ala Ser Ala Phe 205 Glu Ile Gin Asp Phe Thr Pro Val1 Lys Giu 110 Glu Asp Lys Lys Phe 190 Gly Tyr Arg Thr Ile Gin Leu Leu Lys Val1 Phe Lys Lys Val Giu 175 Asp Gly Ser Gin Leu 255 Phe Leu Lys Met Leu Asp Pro His Giu Leu 160 Phe Asn Ile Asp Tyr 240 Ser I.iIMqFFT Z .:-,C1996 1243 Ala Met Ala Asn Met Ser Gly Glu Asn Asp Tyr Lys Ile Thr Trp Leu 260 265 270 Lys Pro Lys Tyr Gin Leu His Ser Ser Asn Asn Ile Lys Pro Leu Met 275 280 285 Ser Asn Thr Glu Leu Leu Asn Met Ile Glu Leu Thr Asn Ile Lys Lys 290 295 300 Glu Tyr Val Met Gly Cys Asn Met Glu Ile Asp Gly Ser Lys Tyr Pro 305 310 315 320 Ile His Lys Asp Trp Gly Phe Phe Gly Lys Ala Lys Val Pro Glu Thr 325 330 335 Trp Arg Asn Lys Ile Trp Glu Cys Ile Lys Asn Lys Val Lys Ser Tyr 340 345 350 Asp Asn Thr Thr Ala Glu Ile Gly Ile Val Trp Lys Lys Asn Thr Tyr 355 360 365 Ser Ile Ser His His 370 INFORMATION FOR SEQ ID NO:1698: SEQUENCE CHARACTERISTICS: LENGTH: 231 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...231 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1698 Lys Asp Tyr Lys Thr Lys Lys Arg Ala Ile Met Lys Thr Met Asn Leu 1 5 10 Asn Glu Phe Phe Thr His Lys Ile Ile Tyr Lys Asp Thr Pro Leu Lys 25 Phe Lys Asp Thr Leu Glu Gin Glu Ile Ser Gln Ala Ser Leu Val Glu 40 Lys Leu Ile Leu Ala Asn Ile Leu Ala Asn Met Val Phe Ala Lys Ile 55 Ser Asn Glu Asn Ala Pro Lys Ile Leu Ile Ser Arg Leu Met Cys Lys 70 75 Phe Ser Pro Ile Asp Tyr Glu Ser Thr Ile Pro Ser Asp Phe Lys Pro 90 Ile Asp Glu Glu Glu Tyr Glu Asp Asp Leu Glu Trp Leu Asn Glu Glu 100 105 110 Lys Glu Asp Arg Leu Phe Asn Tyr Tyr Leu Phe Leu Asn Gly Ile Lys 115 120 125 Glu Ser Asp Val Glu Glu Val Phe Asn Glu Ser Val Glu Ile Tyr Asp 130 135 140 Glu Cys Leu Ile Glu Ile Ala Gln Asn Val Leu Lys Asp Lys Phe Ser 145 150 155 160 Tyr Asp Ile Asp Leu Leu Gin Val Leu Val Lys Gly Tyr Ala Lys Glu 165 170 175 Ile Arg Glu Phe Leu Ser Tyr Lys Pro Ile Lys Glu Ile Lys Asp Phe 180 185 190 Lys Asp Lys Asp Thr Ala Leu Tyr Ile Ser Leu Gly Lys Asp Tyr Asp 195 200 205 Lys Glu Lys Glu Pro Phe Ser Lys Lys Leu Gin Gin Cys Phe Lys Glu POT/US 96/0912Z IPEA iUd i8 DEC 1996 1244 210 215 220 Ile Leu Glu Ser Lys Gly Ile 225 230 INFORMATION FOR SEQ ID NO:1699: SEQUENCE CHARACTERISTICS: LENGTH: 421 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...421 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1699 Met Lys Gly Leu Thr Met Lys Lys Leu Val Phe Ser Met Leu Leu Cys 1 5 10 Cys Lys Ser Val Phe Ala Glu Gly Glu Thr Pro Leu Ile Val Asn Asp 25 Pro Glu Thr His Val Ser Gin Ala Thr Ile Ile Gly Lys Met Val Asp 40 45 w Ser Ile Lys Arg Tyr Glu Glu Ile Ile Ser Lys Ala Gln Ala Gln Val 55 Asn Gln Leu Gln Lys Val Asn Asn Met Ile Asn Thr Thr Asn Ser Leu 70 75 Ile Ser Ser Ser Ala Ile Thr Leu Ala Asn Pro Met Gln Val Leu Gin 90 Asn Ala Gln Tyr Gln Ile Glu Ser Ile Arg Tyr Asn Tyr Glu Asn Leu 100 105 110 Lys Gln Ser Ile Glu Asn Trp Asn Ala Gln Asn Leu Leu Arg Asn Lys 115 120 125 Tyr Leu Gin Gln Gln Cys Pro Trp Leu Asn Val Asn Ala Leu Thr Asn 130 135 140 Asn Lys Ile Val Asn Leu Lys Asp Leu Asn Asn Leu Ile Thr Lys Asn 145 150 155 160 Gly Glu Gin Thr Gin Thr Ala Arg Asp Val Gin Asn Leu Ile Gln Ser 165 170 175 Ile Ser Gly Ser Gly Tyr Gly Asn Met Gln Ser Leu Ala Gly Glu Leu 180 185 190 Ser Gly Arg Ala Trp Gly Glu Met Leu Cys Lys Met Val Asn Asp Ser 195 200 205 Asn Tyr Glu Ser GIu Gln Ala Leu Leu Ala Thr Gly Asn Asn Pro Glu 210 215 220 Glu Gin Lys Arg Arg Phe Leu Leu Arg Val Lys Lys Lys Val Asn Asp 225 230 235 240 Asn Lys Gln Leu Lys Asp Lys Leu Asp Pro Phe Leu Lys Arg Leu Asp 245 250 255 Val Leu Gln Thr Glu Phe Gly Val Thr Asp Pro Thr Ala Asn His Asn 260 265 270 Lys Gln Gly lie His Tyr Cys Thr Glu Asn Lys Glu Thr Gly Lys Cys 275 280 285 Asp Pro Ile Lys Asn Val Phe Arg Thr Thr Arg Leu Asp Asn Glu Leu 290 295 300 Glu Gln Glu Ile Gln Thr Leu Thr Leu Asp Leu Thr Lys Ala Ser Asn 305 310 315 320 POT/US 96/0i1 2 L<-J Ji t3 iC1996 1245 Lys Asp Ala Gln Ser Gln Ala Tyr Ala Asn Phe Asn Gln Arg Ile Lys 325 330 335 Leu Leu Thr Leu Lys Tyr Leu Lys Glu Ile Thr Asn Gln Met Leu Phe 340 345 350 Leu Asn Gin Thr Met Ala Met Gin Ser Glu Ile Met Thr Asp Asp Tyr 355 360 365 Phe Arg Gln Asn Asn Asp Gly Phe Gly Glu Lys Glu Asn His Ile Asp 370 375 380 Lys Gln Leu Thr Gin Lys Arg Ile Asn Glu Arg Glu Arg Ala Arg Ile 385 390 395 400 Tyr Phe Gln Asn Pro Asn Val Lys Phe Asp Gin Phe Gly Phe Pro Ile 405 410 415 Phe Ser Ile Trp Asp 420 INFORMATION FOR SEQ ID NO:1700: SEQUENCE CHARACTERISTICS: LENGTH: 446 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...446 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1700 Lys Arg Trp Trp Tyr Phe Val Arg Ala Phe Leu Asn Arg Ser Phe Ala 1 5 10 Pro Leu Leu Asn Pro Asn Glu Asn Leu Leu Asp Gln Val Lys Ser Ser 25 Ile Ile Leu Lys Lys Gly Val Ser Tyr Phe Asp Trp Gly Ala Ser Gly 40 Leu Ala Ser Ala Leu Val Glu Lys Arg Val Lys Ser Leu Leu Pro Tyr 55 Tyr Ala Asn Ala His Ser Val Ala Ser Lys His Ala Ile Leu Met Gly 70 75 Met Leu Leu Lys Glu Cys Gin Glu Lys Leu Lys Arg Ser Leu Asn Leu 90 Ser Ala Asn His Cys Val Leu Ser Ala Gly Tyr Gly Ala Ser Ser Ala 100 105 110 lie Lys Lys Phe Gin Glu lie Leu Gly Val Cys Ile Pro Ser Lys Thr 115 120 125 Lys Lys Asn Leu Glu Pro Tyr Leu Lys Asp Met Ala Leu Lys Arg Val 130 135 140 Ile Val Gly Pro Tyr Glu His His Ser Asn Glu Val Ser Trp Arg Glu 145 150 155 160 Gly Leu Cys Glu Val Val Arg Ile Pro Leu Asn Glu His Gly Leu Leu 165 170 175 Asp Leu Glu Ile Leu Glu Gin Thr Leu Lys Lys Thr Pro Asn Ser Leu 180 185 190 Val Ser Val Ser Ala Ala Ser Asn Val Thr Gly Ile Leu Thr Pro Leu 195 200 205 Lys Glu Val Ser Ser Leu Cys Lys GIu Tyr Arg Ala Ile Leu Ala Leu 210 215 220 Asp Leu Ala Asn Phe Ser Ala His Ala Asn Pro Lys Asp Cys Glu Tyr
SHEET.;
4 .~tu'J o- 01996 1246 Thr Gly Ser Glu 290 Leu Cys Leu Leu Ser 370 Thr Asn Leu Leu Gly Leu Phe 275 Phe Leu Gly Val Thr 355 Pro Arg Leu Arg Leu 435 Lys Asp 265 Ile Leu Ala Lys Leu 345 Val Val Ala Ser Thr 425 Ala Leu 250 Leu Lys Arg Leu Lys 330 Pro Val Leu Gly Asp 410 His Val 235 Leu Ile Tyr Glu Ala 315 Glu Ala Ala Ser Pro 395 Phe Ser Lys INFORMATION FOR SEQ ID NO:1701: SEQUENCE CHARACTERISTICS: LENGTH: 430 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...430 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1701 Tyr Val Ile Glu Leu Asp Ile Asn Ala Ser Asp Lys 1 5 10 Arg Ala Val Ile Phe Ser Leu Leu Ala Gln Lys Pro 25 Asn Phe Leu Met Gly Glu Asp Cys Leu Ser Ser Leu 40 Asn Leu Gly Ala Lys Val Glu Asn Thr Ala Lys Asn 55 Thr Pro Pro Thr Thr Ile Lys Glu Pro Asn Lys Ile 70 75 Asn Ser Gly Thr Ser Met Arg Leu Tyr Ser Gly Leu 90 Lys Gly Leu Phe Val Leu Ser Gly Asp Asn Ser Leu 100 105 Met Lys Arg Ile Ile GIu Pro Leu Lys Ala Phe Gly 115 120 Ser Cys Glu Ser Leu Leu Asn Ala 125 Leu Phe Ile Phe Asn Ser Ala 110 Lys Ser Val Ala Lys Cys Ala Arg Ile His Arg Gin Ile Asn Gin Pro Leu ii -7 -1 i (I w U. :1 pT PCT/US 9 6 0912 2 IP C 1996 Gly Arg 130 Leu Lys 145 Ser Ala Lys GIu Leu Gly Leu Glu 210 Ser Ser 225 Arg Leu Phe Glu Ser Lys Leu Lys 290 Ile Pro 305 Val Arg Ala Val Glu Asp Gin His 370 His Arg 385 Glu Ile Leu Trp Glu Asp Asn His Phe Ala Pro 135 Cys Ile Glu 180 Asn Pro Phe Leu Leu 260 Leu Ile Leu Ala Ser 340 Phe Ser Ala Asn Asn 420 Asp Leu 165 Leu Ile Leu Phe Lys 245 Lys Glu Ser Ser Lys 325 Asn Tyr Lys Met Leu 405 Leu Tyr 150 Ser Ser Gin Glu Leu 230 Asn Lys Val Ile Ile 310 Asp Phe Ile Ile Ser 390 Glu Phe Glu Ala Arg Asn Ser 215 Ala Val Met Ile Asp 295 Ala Leu Lys Glu Lys 375 Phe Cys Lys Ser Leu Asn Gin 200 Phe Leu Leu Gly Gly 280 Gin Met Arg Ala Gly 360 Pro Ala Ala Lys 1247 Leu Ala Ile 140 Ile Ala Ser 155 Ala Gln Gly 170 Thr Glu Ile Gly Val Leu Phe Thr Ile 220 Cys Ala Ile 235 Asn Pro Thr 250 His Ile Glu Ile Tyr Ile Ile Ala Ser 300 Phe Ala Lys 315 Lys Glu Ser 330 Gly Ile Glu Gly Asp Ala Ile Ile Lys 380 Leu Thr Leu 395 Ile Ser Phe 410 Ser Leu Asn Val Ala Ile Met Lys 205 Ala Thr Arg Tyr Glu 285 Leu Gly Asp Cys Ser 365 Ser Ala Pro Gly Gly Gin Ser Leu 190 Ile Asn Pro Ile Val 270 His Ile Lys Arg Glu 350 Gln Phe Leu Thr Asn 430 Gly Vl I Ala 175 Lys Ser Asp Lys Glu 255 Ile Ala Asp Ser Ile 335 Glu Leu Asn Pro Phe 415 Pro Lys 160 Tyr Ser Pro Pro Ser 240 Ala Gin Pro Glu Met 320 Lys Phe Lys Asp Leu 400 Gin INFORMATION FOR SEQ ID NO:1702: SEQUENCE CHARACTERISTICS: LENGTH: 192 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...192 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1702 Asn Ala Arg Thr Phe Leu Ser Gln Pro Phe Ser Phe Gly Ser Ile Tyr 1 5 10 Ser Lys Lys Gly Val Ser Met Glu Ile Lys Met Ala Lys Asp Tyr Gly 25 Phe Cys Phe Gly Val Lys Arg Ala Ile Gln Ile Ala Glu Lys Asn Gin PCT/US 96/09122 PF 1 j DEC 1996 1248 40 Asn Ser Leu Ile Phe Gly Ser leu Ile His Asn Ala Lys Glu Ile Asn 55 Arg Leu Glu Lys Asn Phe Asn Val Lys Ile Glu Glu Asp Pro Lys Lys 70 75 Ile Pro Lys Asn Lys Ser Val Ile Ile Arg Thr His Gly Ile Pro Lys 90 Gin Asp Leu Glu Tyr Leu Lys Asn Lys Gly Val Lys Ile Thr Asp Ala 100 105 110 Thr Cys Pro Tyr Val Ile Lys Pro Gln Gln Ile Val Glu Ser Met Ser 115 120 125 Lys Glu Gly Tyr Gin Ile Val Leu Phe Gly Asp Ile Asn His Pro Glu 130 135 140 Val Lys Gly Val Ile Ser Tyr Ala Thr Asn Gin Ala Leu Val Val Asn 145 150 155 160 Ser Leu Glu Glu Leu Gin Glu Lys Lys Leu Gin Arg Lys Val Ala Leu 165 170 175 Val Ser Gin Thr Thr Lys Gin Thr Pro Lys Leu Leu Gin Ile Ala Ser 180 185 190 INFORMATION FOR SEQ ID NO:1703: SEQUENCE CHARACTERISTICS: LENGTH: 87 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...87 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1703 Lys Leu Pro Ile His Ala Phe Val Leu Met Cys Leu Ala Ile Pro Ser 1 5 10 Lys Val Ile Ala Ile Asn Asp Asn Val Ala Leu Leu Glu Thr Leu Gly 25 Val Gln Arg Glu Ala Ser Leu Asp Leu Met Gly Glu Ser Val Lys Val 40 Gly Asp Tyr Val Leu Leu His Ile Gly Tyr Val Met Ser Lys Ile Asp 55 Glu Lys Glu Ala Leu Glu Ser Ile Glu Leu Tyr Gln Glu Met Ile Ala 70 75 Glu Val Asn Glu Thr His Glu INFORMATION FOR SEQ ID NO:1704: SEQUENCE CHARACTERISTICS: LENGTH: 246 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES POUS 96/091?.? A~'NUJS A DEC IJ9 1249 Zvi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1 .246 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1704 1Lys Gly Thr Ser Met Ser Glu Gin Arg Lys Glu Ser Pro Lys Gly Thr Val1 Lys Glu Ala Val1 145 Leu Phe Val1 Lys Leu 225 Gin Asn Asn Ser Met Glu Gly Ala Leu 130 Cys Sen Met Phe Pro 210 Glu Sen Leu Asp Val1 Leu Gly Val1 Ser 115 Giu Pro Val1 Cys Asn 195 Giu Asp Thr Ser Ile Cys Giu Asp Ser 100 Met Lys Sen Pro Ala 180 Phe Ala Phe His Lys Met Ser Phe Arg Thr 105 Phe Ile Gly Lys Ile 185 Val1 Met Ile Lys Ser Lys Asp Thr Asp Ile Ala Val1 170 Se r Lys Sen Val1 Giu Pro Asp 75 Ala Gly Leu Giu Ala 155 Leu Lys Glu Ser Lys 235 Giu Arg Gly Phe Asp Giu Leu As n 140 Met Lys Ala Asp Lys 220 Leu Lys Tyr Ser Lys Arg Ala Lys 2.25 Val1 Asn Tyr Asp Met 205 Asp Asn Leu Lys Lys Cys Arg His Giu Asn Val1 'khr 175 Ile Lys Lys Asn Ser Glu Thr Val1 Lys Leu Gly Leu Leu 160 Met Giu Leu Ser Tyr 240 Phe Leu Leu Glu Lys Arg Glu Asn INFORMATION FOR SEQ ID NO:1705: SEQUENCE CHARACTERISTICS: LENGTH: 957 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacten pyloni (ix) FEATURE: NAME/KEY: misc-feature LOCATION .957 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1705 Gly Lys Ile Met Ala Lys Lys Lys Gin Giu Val Arg Asn Asn Glu Ile PUS 96/0912 LAU~ 10 L JLG 1996 1250 1 5 10 Phe Val Ala Gin Lys Leu Ala Glu Giu Glu Leu Asn Ala Asn Giu Ile 25 Asn Asp Pro Leu Glu Met Leu Asp Phe Lys Ser Phe Asp Asp Asn Lys 40 Glu Leu Leu Asp Tyr Gin Gin Gin Ala Leu Ile Asn Ala Phe Arg Val s0 55 Leu Val Ala Tyr Phe Arg Asp Phe Lys Glu Ser Lys Lys Glu Phe Tyr 70 75 Ala Phe Tyr Gin Lys His Tyr Ser Phe Ala Asn Cys Asp Phe Ala Lys 90 Lys Lys Leu Asn His Leu Leu Lys Ser His Phe Lys Val Giu Asn His 100 105 110 Cys Val Arg Phe Glu Asn Phe Ile Asn Arg Leu Ala Phe Tyr Met Ala 115 120 125 Thr Gly Ser Gly Lys Thr Ile Val Ile Ile Lys Leu Val Giu Leu Leu 130 135 140 Ser Val Ala Met Gly Met Gly Leu Ile Pro Lys Lys Asn Ile Met Phe 145 150 155 160 Phe Ser Ala Asn Glu His Leu Ile Lys Gin Phe Giu Lys Glu Ile Giu 165 170 175 Lys Tyr Asn Arg Asn Lys Asp Tyr Ser Lys Gin Ile Asp Phe Lys Asn 180 185 190 Leu Lys Ser Val Lys Asn Lys Asp Phe Tyr Arg Ala Pro Lys Asp Ser 195 .200 205 Leu Met Lys Giu Ile Ala Leu Phe Tyr Tyr Arg Ala Asp Leu Met Ser 210 215 220 Asp Glu Glu Ser Lys Glu Asn Leu Leu Asn Tyr Lys Asp Cys Trp Asp 225 230 235 240 Asn Gly Giu Asn Tyr Val Ile Leu Asp Giu Ala His Lys Giy Asn Lys 245 250 -255 Thr Glu Ser Lys Arg Gin Ala Ile Phe Ser Leu Leu Ser Leu Lys Giy 260 265 270 Phe Leu Phe Asn Phe Ser Ala Thr Phe Thr Giu Giu Ser Asp Leu Ile 275 280 285 Thr Ala Val Tyr Asn Leu Ser Val Gly Giu Trp Val Lys Leu Gly Tyr 290 295 300 Gly Lys Giu Ser Vai Leu Leu Lys Lys Asn Asn Leu Asn Ala Phe Lys 305 310 315 320 Giu Leu Lys Asp Leu Asn Asp Arg Giu Lys Glu Ile Ala Leu Leu Lys 325 330 335 Ala Leu Leu Leu Leu Gly Met Gin Lys Arg Tyr Lys Val Giu Gly Tyr 340 345 350 Phe His Asp Pro Leu Met Leu Vai Phe Thr His Ser Val Asn Met Glu 355 360 365 Asn Ser Asp Ala Glu Ile Phe Phe Lys Thr Leu Ala Arg Val Ile Glu 370 375 380 Asn Asp Asp Giu Ser Asp Phe Ser Lys Ala Lys Asp Asp Leu Leu Giu 385 390 395 400 Giu Leu Lys Asn Pro Giu Phe Leu Phe Ser Asp Gly Lys Asp Lys Giu 405 410 415 Lys Asp Tyr Lys Ile Giu Val Phe Lys Giu Ser Leu Lys Gly Met Asp 420 425 430 Phe Lys Gly Leu Lys Giu Ala Val Phe Tyr Ala Ser Asn Gly His Ile 435 440 445 Giu Val Ile Ile Asn Pro Lys Asn Asn Gin Giu Ile Ala Phe Lys Leu 450 455 460 Asn Thr Ser Asp Lys Vai Phe Cys Leu Ile Arg Ile Gly Asp Ile Thr 465 470 475 480 Giu Trp Ile Arg Giu Lys Leu Lys Ser Val Lys Vai Val Ser Lys Asn 485 490 495 Leu Ser Phe Lys Giu Glu Ser Tyr Phe Ser Gin Ile Asp Lys Ser Ser 500 505 510 Ile Asn Ile Leu Val Gly Ser Arg Ala Phe Asp Thr Gly Trp Asp Ser 515 520 525 TJ/US 9 6 091? iPEA/'L ^o L 996 1251 Thr Arg Pro Ser Val Ile Leu Phe Leu Asn Ile Gly Leu Asp.Asp Asp 530 535 540 Ala Lys Lys Leu Val Lys Gln Ser Phe Gly Arg Gly Val Arg Ile Glu 545 550 555 560 Ser Val Lys Asn Gln Arg Gln Arg Leu Ala Tyr Leu Glu Ile Asp Glu 565 570 575 Ala Ile Lys Asp Lys Leu Lys Pro Asn Ala Ala Met Leu Giu Met Leu 580 585 590 Phe Val Ile Pro Thr Asn His Ala Ser Leu Glu Ala Ile Leu Lys Phe 595 600 605 Gin Lys Giu Ser Glu Asn Gly Gly Glu Asn Arg Gly Pro Trp Arg Glu 610 615 620 Ile Lys Leu Glu Lys Thr Arg Ile Glu His Ala Leu Phe Val Pro Cys 625 630 635 640 Tyr Arg Lys Glu Gin Thr Asn Ala Leu Lys Ile Ser Gln Ser Ala Ser 645 650 655 Phe Lys Met Ser Glu Lys Asn Phe Lys Asp Leu Lys Glu His Phe His 660 665 670 Leu Met Ser Glu Lys His Phe Ile Leu Lys His Glu Ile Tyr Asp Pro 675 680 685 Lys Asp Tyr Ala Leu Leu Lys Glu Met Ile Gln Thr Ala His Phe Lys 690 695 700 Lys Val Ser Thr Trp His Tyr Lys Asp Leu Asp Tyr Met Ile Ser Glu 705 710 715 720 Ile Lys Gly Lys Leu Tyr Pro Asn Gln Lys Val Pro Lys Asp Glu Phe 725 730 735 Asn Ala Leu Asp Asn Glu Lys Ile Val His Phe Lys Arg Val Lys Val 740 745 750 Lys Ala Asp Lys Lys Glu Lys Leu Ile Gln Thr Ile Gln Glu Val Lys 755 760 765 Glu His Ala Pro Leu Asp-Lys Glu Thr Leu Arg Lys Lys Ile Ala Gin 770 775 780 Gly Glu Ile Asp Pro Tyr Asp Thr Glu Lys His Lys Gln Asp Arg Thr 785 790 795 800 Phe Lys Val Gly Asp Ala Glu Leu Leu Lys Leu Lys Glu His Tyr Tyr 805 810 815 Thr Pro Leu Ile Lys Ala Lys Asn Cys Asp Trp Leu Lys His Val Val 820 825 830 Lys Val Lys Ser Glu Ser Asp Phe Leu Glu Glu Leu Leu Lys Ile Thr 835 840 845 Glu Thr Leu Gln Glu Asn Tyr Asp Phe Trp Ala Phe Ser Lys Ile Asp 850 855 860 Glu His Leu Asp Asn Leu Phe Ile Pro Tyr lie Asp Asn Ala Thr Glu 865 870 875 880 Arg Arg Phe Phe Pro Asp Phe Ile Phe Trp Leu Gln Lys Gly Gly Thr 885 890 895 Gin Ile Ile Cys Phe Ile Asp Pro Lys Gly Ser Lys His Thr Asp Tyr 900 905 910 Glu His Lys Ala Asp Ala Tyr Gin Leu Phe Glu Asp Lys Val Phe Asn 915 920 925 Pro Lys Asp Asp Pro Asn Leu Lys lie Lys Val Val Leu Lys Phe Tyr 930 935 940 Gly Asp Lys Asp Asp Val Gly Glu Arg Tyr Arg Asp Leu 945 950 955 INFORMATION FOR SEQ ID NO:1706: SEQUENCE CHARACTERISTICS: LENGTH: 249 amino acids TYPE: amino acid TOPOLOGY: linear RA. (ii) MOLECULE TYPE: protein 1252 (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NME/KEY: misc-feature LOCATION .249 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2.706 Cys Ile Arg Val1 Glu Glu Thr Val1 Leu Arg 145 Met Gin G ly Val1 Ser 225 His Met Phe Val1 Gin Arg Arg Pro Ser Val 1.30 Leu Ile Glu Asp Ph.
210 Ala Val1 Arg Tyr Lys Ala Leu Leu Thr Leu 2.25 Ser As n Gly Leu Gin 195 Val1 Val1 Phe Phe Tyr Phe Lys Ph. Leu Trp Leu Leu Gly Ile Ph. Leu Ser Ala Tyr Phe Ile LeU Asn Sen Ph. Met 2.00 Asn Pro His Asn Gly Phe Gin Asn 2.65 Val Val 2.80 Val Leu Gly Glu Lou Lys Leu Ser 245 Asp Ile Lou Met Phe Gin 55 Glu Ala 70 Ile Tyr Thr Ser Ile Val Gin Ala 2.35 Leu Asn 150 Gin Val.
Asp Phe Thr Sen Val Ser 215 Asn Ala 230 Gly Val Lys Ser 40 Ala Leu Pro Phe Asn 2.20 Ile Ala Lou Ile Gly 200 Ser Ph.
Lys Gly 25 Ala Gin Lys Leu Ile 105 Leu Gly His Gly Val 2.85 Leu Val1 Leu Asn Sen Lys Asn Lou Giu 90 Asn Glu Ile Lys Ph.
170 Pro Asp G2.u Ser Ser Asn Ile Glu 75 As n Leu G2.u Ala Arg 155 Ser Gly Asp Glu 235 Ser Sen Lys As n Pro Glu Asn Val2 1.40 Cys Gly Ala Ile His 220 Ala Tyr Leu Giu Ala Lys Asp Lys 2.25 Leu Ala Thr G2.u Phe 205 Tyr Lys Ile Leu Phe Asp Met Thr 110 Ile Glu Tyr Asn Ile 1.90 Gly Thr Leu Ph.
Ser Asp Gin Leu Thr His Tyr Lys Sen Ph.
2.75 Asn Ala Tyr Leu Leu Asp Asn Lys Lys Tyr Sen Gly Gly Val1 2.60 Lys Ile Gly Lys Arg 240 INFORMATION FOR SEQ ID NO:1707: SEQUENCE CHARACTERISTICS: LENGTH: 154 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misctfeature LOCATION 1 1254 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:2.707 tIE/U 96/09i? PEAoS l8 DEC 1996 1253 Trp 1 Lys Phe Va 1 Ile Ala Ile Phe Glu Phe 145 Tyr Ser Ala Asn Gly Phe Val Phe Ala 130 Gly Lys Phe Ser Ser Phe Lys Gly 100 Trp Ala Tyr Lys 5 Ser Ser Ser Leu Lys Val Phe Asp Trp Glu Arg Val Ala Ile 70 Ser Ser Gly Leu Val 150 Arg Asn Tyr Val 55 Ser Lys Leu Phe Leu 135 Asp Asn Trp Phe Ala Phe Ile Leu Ile 120 Val Arg Pro Ser Phe Trp Ser Phe Leu 105 Asn Gly Tyr Val Ile His Arg Asn Arg Leu Leu Val Leu Met Pro Glu Phe Val 75 Thr Arg Phe Ala Leu Pro Trp Ala Val 125 Val Ile Gin 140 Lys Arg Thr His Asp Ile His Phe Ile Ile His Ala Leu Met Ser Leu Ile Phe INFORMATION FOR SEQ ID NO:1708: SEQUENCE CHARACTERISTICS: LENGTH: 76 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...76 (xi) SEQUENCE DESCRIPTION: SEQ ID N0:1708 Trp Ala Lys Gly Ala Gly Ala Leu Val Leu Glu Glu Tyr Glu Ser Ala 1 5 10 Lys Lys Arg Gly Ala Lys Ile Tyr Ala Glu Phe Ala Gly Tyr Gly Glu 20 25 Ser Gly Asp Ala Asn His Ile Thr Ala Pro Ala Pro Glu Gly Glu Arg 40 Ala Phe Lys Ala Met Lys Met Ala Leu Glu Met Ala Lys Val Glu Val 55 Cys Tyr Val Asn Ala His Gly Asp Lys His Ala Leu 70 INFORMATION FOR SEQ ID NO:1709: SEQUENCE CHARACTERISTICS: LENGTH: 111 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein S(iii) HYPOTHETICAL: YES
TO
'/VT i PCT/u6 96/09122 IPE Uo -L ou L C 1996 1254 (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...111 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1709 Thr Pro Met Gly Thr Ser Thr His Tyr Asn Asp Trp Tyr Glu Ser Ile 1 5 10 Ala Leu Lys Asn Val Phe Gly Ser Lys Glu Lys Val Pro Pro Val Ser 25 Ser Thr Lys Gly Gin Ile Gly His Cys Leu Gly Ala Ala Gly Ala Leu 40 Val Ala Val Ile Ser Ile Met Ala Met Asn Gln Gly Ile Leu Pro Pro 55 Thr Ile Asn Gln Glu Thr Pro Asp Pro Glu Cys Asp Leu Asp Tyr Ile 70 75 Pro Asn Thr Ala Arg Glu Lys Gln Val Asn Ala Val Met Ser Asn Ser 90 Phe Gly Phe Gly Gly Thr Asn Gly Val Val Ile Phe Lys Lys Ala 100 105 110 INFORMATION FOR SEQ ID NO:1710: SEQUENCE CHARACTERISTICS: LENGTH: 189 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION 1...189 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1710 Gly Pro Ile Gln Ser Ala Pro Ala Met Asn Lys Leu Phe Leu Ala Phe 1 5 10 Ile Val Gly Gly Met Leu Leu Ser Ala Asp Ala Leu Asn Asp Lys Ile 25 Glu Asn Leu Met Gly Glu Arg Ser Tyr His Met Asn Lys Leu Phe Leu 40 Glu Arg Leu Phe Lys Asn Arg Lys Asp Phe Tyr Glu Met Gly Arg Leu 55 Asp Ser Leu Lys Leu Leu Asn Thr Leu Lys Glu Asn Gly Leu Leu Ser 70 75 Phe Asn Phe Asp Lys Pro Ser Val Leu Lys Ile Thr Phe Lys Ala Ser 90 Ser Asn Pro Leu Ala Phe Ala Lys Ser Ile Asn Asn Ser Leu Asn Met 100 105 110 Met Gly Tyr Ser Tyr Val Leu Pro Ile Arg Met Gln Ser Ser Ser Gly 115 120 125 Glu Asn Val Phe Ser Tyr Glu Leu Lys Thr Glu Tyr Val Leu Asp Pro 130 135 140 Asn Ile Leu Ile Glu Thr Met Lys Arg His Gly Phe Asp Phe Met Asp 145 150 155 160
A,
PC- C 091)2 IPEAIUS 18 D E C'1996 1255 Ile Arg Arg Val Ser Leu Lys Glu Trp Giu Tyr Asp Ph. Ala Leu Gin 165 170 175 Lys Ile Lys Leu Pro Asn Gly Glu Ser Leu Ser Phe Glu 180 185 INFORMATION FOR SEQ ID NO:i711: SEQUENCE CHARACTERISTICS: LENGTH: 321 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: CA) NAME/KEY: misc-feature LOCATION 1 .321 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1711 Met Giu Gin Asn Lys Lys Sen Leu Giu Asn Leu Asp Leu Sen Asp Val 1 5 10 Gin Asn Ile Ser Lys Asp Ile Ser Gly Thr Ala Leu Glu Giu Leu Sen 25 Leu Lys Asn Leu Asp Lys Asn Leu Gin Ile Leu Lys Giu Val Gly Ala 40 Ala Giu Ile Cys Lys Ala Thr Lys Ile Ala Ser Lys Asn Ile His Ser 55 Ilie Leu Giu Lys Ang Tyr Giu Ser Leu Sen Ang Val His Ala Arg Gly 70 75 s0 Phe Ilie Gin Ile Leu Giu His Giu Tyr Lys Ilie Asp Leu Ser Ala Trp 90 Val Lys Giu Phe Asp Lys Val Cys Val Ph. Lys Glu Gly Val Gly Glu 100 105 110 Giu Gin Lys Gin Giu Thr Ser Pro Giu Giu Thr Ala Lys Lys Pro Leu 115 120 125 Lys Val Giu Leu Asp Tyr Se Ile Asn Gin Ala Asn Thr Ser Leu Ser 130 135 140 Lys Lys Ser Sen Lys Trp Lys Pro Phe Val Ile Val Leu Gly Val Val 145 150 155 160 Val Ile Ile Lou Val Val Val Ile Ile Gin Asn Sen Ser Sen Leu Lys 165 170 175 Giu Glu Arg Giu Gin Giu Ang Ala Ile Lys Pro Asp Thn Lys Asn Asn 180 185 190 Sen Phe Asn Giu Thr Asn Pro Thn Giu Giu Lys Lys Leu Glu Pro Thr 195 200 205 Pro Lys Leu Giu Giu Lys His Lys Giu Gin Asp Lys Gin Gly Lys Giu 210 215 220 Ala Ile Lys Giu Asn Pro Asn Thr Ile Tyr Ile Ile Pro Lys Arg Asp 225 230 235 240 Ile Trp Vai Giu Val Ile Asp Leu Asp Glu Lys Lys Asn Ser Ph. Gin 245 250 Lys Val Ph. Lys Lys Sen Tyr Pro Leu Giu Ala Lys Asn His Arg Leu 260 265 270 Leu Leu Ang Phe Gly His Giy His Leu Ile Leu Lys Asn Asn His Gin 275 280 285 Giu Gin Asp Tyr Asn Asp Ser Lys Thn Ang Arg Phe Leu Tyr Giu Pro 290 295 300 AsnLys Gly Leu Thn Leu Ile Asn Giu Ala Gin Tyr Lys Ala Leu Gln NT0 PrT/S 9 /0912 iPEAU Ad DEC 1996 1256 305 310 315 320 Gin INFORMATION FOR SEQ ID NO:1712: SEQUENCE CHARACTERISTICS: LENGTH: 115 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...115 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1712 Arg Ser Gly Asn Thr Thr Leu Pro Tyr Lys Arg Ser Ser Ser Leu Thr 1 5 10 Ala Arg Ala Leu Val Leu Ser Ser Asp Pro Val Glu Phe Lys Glu Ala 25 Ser Gly Lys Tyr Trp Leu Ser Val Asn Gln Asn Ala Tyr Leu Lys Ile 40 Ser Ser Asn Asn Pro Leu Trp Gln Pro Lys Ile Ile Phe Tyr Asp Glu 55 Asn Leu Lys Ile Ile Gln Ile Ile Ala Lys Glu Asn Arg Gln Gln Glu 70 75 Ile Ala Leu Asn Leu Leu Asp Gly Val Arg Phe Ile His Ile Thr Asp 90 Ala Lys Asn Pro Ile Ile Leu Lys Asn Gly Ile Ser Val Val Phe Asp 100 105 110 Ala Met Pro 115 INFORMATION FOR SEQ ID NO:1713: SEQUENCE CHARACTERISTICS: LENGTH: 205 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...205 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1713 Arg Ser Leu Ala Cys Trp Leu Arg Leu Ser Leu Phe Lys Gly Ile Ile 1 5 10 iPEiUS D C19 6 1257 Met Thr Val Met Ile Met Thr Gly Gly 145 Lys Tyr Tyr Phe Leu Phe Gin Leu Asn Gly Leu 130 Ala Ala Ser Val Asp Val Leu Ser Cys Cys Leu 115 Phe Leu Leu Phe Gin 195 Ser Leu Tyr Leu Leu Cys 100 Val Gly Gly Ile Tyr 180 Met Ile Val Lys Ser Ile Arg Val Thr Gin Ala 165 Leu Gin Val Trp Ser Asn 70 Lys Ala Leu Val Ala 150 Thr Ile Val Tyr Ile Ile 55 Ile Lys Trp Ser Val 135 Ser Ala Leu Asp Phe Phe Asn Lys Ser 25 Ser Leu Tyr Leu Val 40 Val Leu Lys Ile Glu Leu Asn Gly Ala Gin Glu Met Met Arg Pro Lys His Gln Val Leu 105 Ile Ile Ser Ser Thr 120 Glu Ile Leu Glu Ala 140 Phe Gly Val Ile Ala 155 Ala Gly Ile Leu Ala 170 Lys Arg Lys Val Tyr 185 Ile Leu Ser Ser Lys 200 Gly Met Leu Asp Lys Lys Ala 125 Phe Pro Ala Asp Lys 205 Phe Thr Arg Ala Gly Gin 110 Pro Asn Ile Ile Leu 190 INFORMATION FOR SEQ ID NO:1714: Lys 1 Leu Leu Prc Ile Glu As( As Ly SEQUENCE CHARACTERISTICS: LENGTH: 136 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...136 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1714 Val Ph* Met Asn Tyr Asp Asn Tyr Trp Asp Glu 5 10 Asn Ile Thr Pro Leu Val Asp Val Met Leu Val 25 Met Val Thr Thr Pro Thr Leu Thr Tyr Lys Glu 40 Ser Gly Ser Lys Thr Ala Arg Ala Thr Gln Asp 55 Arg Met Asp Lys Asp Ala Lys Ile Tyr Ile Asp 70 75 1 Tyr Asn Ser Phe Pro Asp Thr Phe Asn Leu Leu 90 p Lys Asp Thr Arg Val Ser Ile Arg Ala Asp Lys 100 105 p Lys Val Ile Tyr Leu Leu Lys Thr Ile Lys Glu 115 120 s Val Ser Leu Ile Thr Ser Pro 130 135 At.; t Asp Leu Glu Lys Ser Ser Arg Ala 125 Lys Leu Ile Val Gin Lys Leu 110 Gly Pro Ala Ala Ile Thr Lys Thr Phe Glu Ile Leu Glu Tyr Tyr Tyr Leu PCT/US 96/09 22 i 309v6 1258 INFORMATION FOR SEQ ID NO:1715: SEQUENCE CHARACTERISTICS: LENGTH: 128 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...128 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1715 Lys Val Gly Pro Ile Cys Met Ser Lys Ser Ala Ile Phe Val Leu Ser 1 Gly Leu Lys Glu Phe Glu Thr Phe Glu Lys Lys Leu Asp Leu Leu Lys Ala Lys Glu Ser Ser .Gly Asp Leu Gin Glu Gin 110 Lys Leu Leu Pro Gly Ser Thr Gly INFORMATION FOR SEQ ID NO:1716: SEQUENCE CHARACTERISTICS: LENGTH: 215 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...215 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1716 Gly Arg Thr Met Lys Tyr Leu Trp Leu Phe Leu Ile Tyr Ala Ile Gly 1 5 10 Leu Phe Ala Thr Asp Lys Thr Leu Asp Ile Ile Lys Thr Ile Gin Lys 25 Leu Pro Lys Ile Glu Val Arg Tyr Ser Ile Asp Asn Asp Ala Asn Tyr 40 NV T Al 1 1S. T i3RC C 996 1259 Ala Leu Lys Leu His Glu Val Leu Ala Asn Asp Leu Lys Thr Ser Gin 55 His Phe Asp Val Ser Gln Asn Lys Glu Gln Gly Ala Ile Asn Tyr Ala 70 75 Glu Leu Lys Asp Lys Lys Val His Leu Val Ala Leu Val Ser Val Ala 90 Val Glu Asn Gly Asn Lys Ile Ser Arg Leu Lys Leu Tyr Asp Val Asp 100 105 110 Thr Gly Thr Leu Lys Lys Thr Phe Asp Tyr Pro Ile Val Ser Leu Asp 115 120 125 Leu Tyr Pro Phe Ala Ala His Asn Met Ala Ile Val Val Asn Asp Tyr 130 135 140 Leu Lys Ala Pro Ser Ile Ala Trp Met Lys Arg Leu Ile Val Phe Ser 145 150 155 160 Lys Tyr Ile Gly Pro Gly Ile Thr Asn Ile Ala Leu Ala Asp Tyr Thr 165 170 175 Met Arg Tyr Gin Lys Glu Ile Ile Lys Asn Asn Arg Leu Asn Ile Phe 180 185 190 Pro Lys Trp Ala Asn Ala Glu Gln Thr Glu Phe Tyr Tyr Thr Gin Met 195 200 205 Ala Glu Lys Arg Pro Trp Phe 210 215 INFORMATION FOR SEQ ID NO:1717: SEQUENCE CHARACTERISTICS: LENGTH: 114 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...114 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1717 Phe Leu Arg Gly Lys Phe Ile Gln Glu Arg Leu Lys Ala Leu Cys Cys 1 5 10 Gin Gly Val Glu Gly Glu Phe Gly Val Leu Tyr Gly His Ser Asn Met 25 Ile Thr Leu Leu Gin Ala Gly Val Val Giu Ile Glu Thr Glu Asn Gin 40 Lys Glu His Ile Ala Ile Asn Trp Gly Tyr Ala Glu Val Thr Asn Glu 55 Arg Val Asp Ile Leu Ala Asp Gly Ala Val Phe Ile Lys Lys Gly Ser 70 75 Asp Asp Arg Asp Asp Ala Ile Ser Arg Ala Lys Lys Leu Leu Glu Asp 90 Ala Ser Ser Asp Arg Leu Ala Val Ser Ser Val Leu Ala Lys Ile Glu 100 105 110 Ser Leu INFORMATION FOR SEQ ID NO:1718: SEQUENCE CHARACTERISTICS: A IPEA/US lb EC 1996 1260 LENGTH: 99 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...99 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1718 Leu Ser Met Arg Ala Ile Ala Ile Val Leu Ala 5 Arg Ile Lys Asn Lys Asn Met Ile Asp Phe Phe Ala Tyr Pro Ile Glu Thr Ala Leu Asn Ser Lys Phe Ile Ser Ser Asp Ser Met Glu Tyr Val Asn 55 Gly Ala Ser Phe Leu Asn Leu Arg Pro Lys Asn 70 Gly His Asp Phe Arg Ser Asp Gly Leu Ser His Lys Arg Lys 1 Lys Leu Val Tyr Gln Ile INFORMATION FOR SEQ ID NO:1719: SEQUENCE CHARACTERISTICS: LENGTH: 256 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...256 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1719 Ile Pro Pro Ser Thr Pro Phe Leu Asn Ile Leu His 1 5 10 Tyr Arg Ser His Tyr Gly Lys Ile Asn Thr Cys Leu 25 Asp Leu Ile Leu Ala Leu Pro Val Tyr Tyr Asp Lys Gly Val Ile Gin Ser Leu Gin Val Gly Ile Ile Gly 55 Gly Glu Ala Gin Ala Leu Asn Leu Arg Asp Ser Lys 70 Ile Gly Leu Tyr Gin Gly Ser Leu Ser Val Ser Lys 85 90 Phe Thr Ile Gly Lys Lys Lys Leu Asp Val Val Lys
RA-
TO
A R ~4 ~.1 1PENJS 1DEC 1996 1261 G )y Ile Giu G ly 145 Ala Tyr Ser Met Cys 225 Glu Phe Met Val1 130 Phe Ile Leu Ser Gly 210 G iu Ala Giu Ala 115 Ile Ser Leu Lys Ile 195 Gly Ser Ile Val Leu 100 Leu Leu Pro Ph.
Vai His Val Ala 165 Asn Arg 180 His Asn Gly Arg Asp Leu Val Arg 245 Gly Pro Leu Phe iso Pro Gly Ala Met Phe 230 Met Val1 Asp Lys 135 As n Lys Leu Lys Gly 215 Gly Giy Lys Giu 120 Glu Gin G ly Tyr Ala 200 Val1 Giu Phe Glu Leu 105 Leu His Gly Gin Val Val Pro Gly 170 His Leu 185 Val Ala Leu Glu Gin Ala Glu Thr 250 Vali Lys Ile Leu Se r Ile Leu Thr Val1 235 Leu Gin Giu Ile 140 Pro Ala Ala Ser Ser 220 Leu Ile Gin Vali 125 G iy Lys Leu Ile Tyr 205 Phe Cys Lys Ser Asp 110 Leu Glu Phe Ala Giy Val Arg Giu 175 Giu Gin 190 Ala Lys Lys Giu Gly Gly Aia Gly 255 INFORMATION FOR SEQ ID NO:i720: SEQUENCE CHARACTERISTICS: LENGTH: 91 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Heiicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .91 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:i720 Gin Thr Ser Arg Ala Thr Thr Leu Giu Val Met Ala Tyr His Met 1 5 10 is Giu Leu Glu Leu Lys Asp Glu Asp Ile Ala Cys Cys Leu Tyr Gly 25 Ser Val Ph. Leu Gin Glu Lys His Leu Gin Asn Ala Phe Giu Thr 3S 40 Lys Gin Asn Gin Asri Thr Asp Tyr Val Ph. Thr Cys Sen Pro Phe 55 Ala Ser Pro Ile Val Leu Leu Ala Leu Lys Thr Ala Phe Lys Trp 70 Leu Lys Sen Ile Gin Thr Arg Ala Arg Lys Ile INFORMATION FOR SEQ ID NO:i721: SEQUENCE CHARACTERISTICS: LENGTH: 3i2 amino acids TYPE: amino acid TOPOLOGY: linear S (ii) MOLECULE TYPE: protein A IPEA/US 18DEC 1996 1262 (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...312 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1721 Met 1 Leu Tyr Phe Gly Ala Val Glu Ser Lys 145 Asn Pro Leu Asn Arg 225 Arg Gin Leu Ile Pro 305 Lys Leu Gin Lys Lys Val Ser Ala Glu 130 Ile Ala Ser Val Pro 210 Leu Asp Asn Gin Cys 290 Cys Ser Asp Gin Lys Cys Ile Ile Pro Thr Pro Val Ser Val Lys 100 Tyr Leu 115 Lys Arg Val Phe Leu Leu Gly Leu 180 Ile Thr 195 Thr Lys Asp Ala His Ala Asn Ala 260 Asp Cys 275 Pro Lys Asn Ile Lys 5 Gly Ala Ile Phe Arg Gly Leu Glu Leu Lys 165 Tyr Glu Arg Phe Pro 245 Thr Lys Val Lys Pro Phe Leu Glu Arg Tyr Phe Leu Thr Ile Ile 70 Gly Asn Ala Leu Asp 150 Pro Arg Asp Met Leu 230 Phe Ser Leu Leu Glu 310 Ile Ile Ser 55 Leu Tyr Ile Leu Gly 135 Asp Lys Glu Lys Leu 215 Pro Asp Leu Pro Glu 295 His Phe Lys 40 Ile Glu Gin Leu Asn 120 Val Gly Val Asn Asp 200 Leu Lys Leu Leu Leu 280 Glu Leu Ala 25 Arg Gly Ile Arg Val 105 Leu Leu Phe Pro Ile 185 Tyr Val Glu Lys Val 265 Ser Ile 10 Leu Lys Asn Ala Asp 90 Pro Lys Lys Arg Pro 170 Lys Gin Thr Val Leu 250 Thr Val Asp Tyr Thr Leu Pro 75 Ser Gin Gin Ala Phe 155 Tyr Ser Arg Ala Val 235 Leu Ser Leu Arg Pro Ala Ile Arg Lys Lys Ala Leu 140 Asn Tyr Tyr Ile Ile 220 Lys Glu Lys Asp Tyr 300 Tyr Phe Lys Ala Tyr Gly Thr Ser 125 Glu Phe Pro Lys Thr 205 Ala Lys Lys Asp Leu 285 Ile Asp Pro Ser Leu Lys His Gly Gly Gin Glu Leu Val Ala Gly 110 Val Ile Leu Gly Asn Gin Phe Cys 175 Glu Ala 190 Ser Ile Asn Pro Leu Tyr Glu Phe 255 Leu Val 270 Lys Leu Leu Ser Thr Ile Asp Ser Val Val Asp Val Ser Phe 160 Leu His Thr Ser Phe 240 Tyr Lys Glu Tyr INFORMATION FOR SEQ ID NO:1722: SEQUENCE CHARACTERISTICS: LENGTH: 197 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: I r LA.uz 11 D EC01996 1263 ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc..feature LOCATION .197 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1722 Lys Val Leu Trp Val Leu Tyr Phe Leu Thr Ser Leu Phe Val1 Arg Leu Leu Leu Il1e Ser 125 Gly Ser Ser Leu INFORMATION FOR SEQ ID, NO:l723: SEQUENCE CHARACTERISTICS: LENGTH: 163 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAM~E/KEY: misc_feature LOCATION .163 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1723 Gin Phe Val Leu Phe Ala Arg Leu His Gly Ala Trp Val Tyr Gly Val 1 5 10 is Lys Phe Pro Phe Arg Lys Asp Phe Leu Gly Asp Gly Gly Ala Tyr Phe 25 Leu Gly Leu Val Cys Gly Ile Ser Leu Leu His Leu Ser Leu Glu Gin 40 Lys Ile Ser Val Phe Phe Gly Leu Asn Leu Met Leu Tyr Pro Vai Ile s0 55 Giu Val Leu Phe Sen Ile Leu Arg Arg Lys Ile Lys Ang Gin Lys Ala
UVAL
PCTIUS 96/091?? i 1o DEC1996 1264 Thr Gin Ile Asp Leu 145 Arg Pro Asp Asn Arg Ser Phe 100 Cys Asn Leu 115 Tyr Ala Leu Gly Tyr Ala Phe 70 Leu His Leu His Thr Asn Tyr Pro Asn Pro 105 Pro Phe Ile Leu Ile 120 Ile Val Ile Ser Leu 135 Tyr Leu Asn Arg Gin 150 INFORMATION FOR SEQ ID NO:1724: SEQUENCE CHARACTERISTICS: LENGTH: 90 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...90 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1724 Met Asn Lys Thr Ile Lys Ala Ala Ala Leu Ala Tyr Asn Met Gly 1 5 10 Asp His Ala Pro Lys Val lle Ala Ser Gly Val Gly Glu Val Ala 25 Arg Ile Ile Gin Lys Ala Lys GIu Tyr Asp Ile Ala Leu Phe Ser 40 Pro Met Leu Val Asp Ser Leu Leu Lys Val Glu Leu Asp Cys Ala 55 Pro Glu Glu Leu Tyr Glu Ser Val Val Gin Val Phe Leu Trp Leu 65 70 75 Ser Val Glu Asn Asn Ala Gin Met Ser Lys Leu Leu Leu Tyr Lys 160 Gin Lys Asn Ile Asn 09 INFORMATION FOR SEQ ID NO:1725: SEQUENCE CHARACTERISTICS: LENGTH: 285 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature POUS 9 6/ 1 2 1265 LOCATION .285 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1725 Val Lys Lys Ser Asn Asn Met Val Val GlU Leu Lys Ile Lys Ser Giu Leu Leu Ile Leu Leu 145 As n Ser Lys Lys Giu 225 Thr Gin Ile Tyr Lys Thr Val1 Gin Leu Ala Glu 130 Ser Cys Lys Phe Giu 210 Arg Lys Asp Ile Glu Gly Leu Leu Lys Ser Arg 115 Leu Gly Pro Thr Asp 195 Leu Gly Glu Ile Ser 275 As n Asp Ile Val1 Ala Ala 100 Trp Val1 Gly As n Thr 180 Leu Cys Ser Leu Tyr 260 Asn Gly Ile Arg Asn Arg Lys Giu Gly Gin Leu 165 His Ser As n Val1 Leu 245 Arg Leu Phe Leu Leu Gly 70 Gin Asn Lys Leu Lys 150 Leu Ser Ile Gin Glu 230 G ly Ile Ile His G ly Ile 55 Val1 Lys Val1 Thr Glu 135 Gin Leu Ile Val1 Met 215 Giu Ile Val1 Arg Ala Vali 40 Asn Asn Ile Phe Lys 120 Asp Arg Cys Leu Phe 200 Cys Ile Lys Phe Arg 280 Leu Ile Cys Leu Gly Glu 105 Ile Lys Val1 Asp Thr 185 Ile Val1 Phe Asn Leu 265 Phe Lys Gly Val Gly Tyr Ser Leu Giu Arg Leu Asn Leu 75 Met Ile Phe 90 Asn Val Ala Lys Ser Arg Val His Phe 140 Ala Ile Ala 155 Glu Ala Thr 170 Leu Leu Ser Thr His Gin Ile Ser Ser 220 Ala Asn Pro 235 Glu His Ala 250 Gly Glu His Lys Ile Arg As n As n Gly Pro Lys Gin Phe Val 125 Tyr Arg Ser Gly Ile 205 0 ly Lys Asp Leu Glu Giu Gly Ser Lys Phe Leu Giu Lys Leu Leu 175 Gin Val1 Ile Ala Lys 255 0 iu Lys Leu Lys Gly Glu Asn Glu Leu Gin Ala 160 Asp Lys Val1 Val1 Val1 240 Ser Pro INFORMATION FOR SEQ ID NO:1726: SEQUENCE CHARACTERISTICS: LENGTH: 147 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .147 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:l726 Leu Phe Cys Ser Cys Leu Tyr Gin Arg Phe Leu Ile Gly Thr Ser Ile 10 1s Gly Ser Sen Ala Se Ilie Ile Pro Leu Ala Ile Ser Ala Ile Pro Phe POT/US 96/0912.2 iP~u .I ±uEC 1996 1266 Val1 Ile Met Thr Ala Arg Gin Asn 145 Val1 Giu Met~ Leu Gdy Gly Ile 130 Lys Lys Thr Leu Ile Gly Asp 115 Iie Leu Thr Leu Ser Leu 100 Val1 Gin Phe Leu Giu Leu Gly Leu Ser Giu His Val Met Ile Val Val Val1 Leu Asn Ala Gly Ile Lys 140 His Val1 Ile Ala Gin 110 Val Leu INFORMATION FOR SEQ ID NO:1727: SEQUENCE CHARACTERISTICS: LENGTH: 279 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .279 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1727 Ser Tyr Phe Cys Tyr Asn Leu Arg Leu Leu Sen Leu Val Lys 1 Thr Gin to Thr Ala Asp Met Ala Thr Leu 145 Glu Met Thr Gly Met Gly Phe Ile Ala 130 Val1 Asp Leu His 35 Phe Gln Met Ser Thr 115 Tyr Thr Thr Arg Ile Lys Giu Gin 100 Gly Thn Sen Thr Ser Asp Lys Ala Vai Gly Lys Arg Glu Gin 165 Leu Tyr Ser Ala Thr Thr Sen Asn 40 Sen Arg Ala Asp 55 Gly Thn Asn Thn 70 Gly Leu Gly Val Ser Pro Lys Glu 105 Gly Phe Ph. Gin 120 Ser Gly Asn Phe 135 Gly Tyr Leu Let.
150 Val Asn Ile G11 Thr Thr Ser As: 10 Thr Asn Ph.
Ser Arg 90 Thr Val Lys Ile rVal 170 Sen Ile G ly Ala Asn Asn Asp Leu Ph. Tyr Gin 60 Asn Thr Thn 75 Pro Ser Ala Giu Asn Asn Gin Leu Pro 125 Leu Asp G1u 140 Pro Gin Ile 155 Asp Gly Thr Ile Giy Gin Leu Ile Leu 110 Asp Gin Thr Val1 Ile 190 Ser Thr Asp Gly Gly Leu Ser 175 Thr Pro Lys Ile Thn Asn Pro 160 Val1 Leu Thr Gin Gly Leu 180 iVal Gln I act Ala Asn Ph.
195 Val Asn Pro Ala Gly 200 Leu His Sen Met Giy 205 Asp Asn Leu Phe Se r 225 Val1 Tyr Thr Se r 210 Gin Arg Giu Val1 1267 Ile Thr Asn Ala Ser Gly Asp Ala Ile Val Gly 215 220 Gly Leu Giy Lys Leu Arg Gin Gly Phe Leu Glu 230 235 Leu Val Glu Glu Met Thr Asp Leu Ile Thr Ala 245 250 Ala Asn Ser Lys Ser Ile Gin Thr Ala Asp Ala 260 265 Asn Ser Leo Lys Arg 275 POUS 9 o9i p I PEA/1--3 13D E C19 9% Asn Pro Asp Leu Ser Asn 240 Gin Arg Ala 255 Met Leo Gin 270 INFORMATION FOR SEQ ID NO:1728: SEQUENCE CHARACTERISTICS: LENGTH: 316 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .316 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1728 1Lys Trp Arg Asn Ser Ser Ser Asp Lys Met Ala Lys Lys Lys Ile Ser Ser Thr Asn Phe Asp Gin Asp 145 Leo Val1 Ala Gly Ser 225 Asp Ser Se r His Glu Lys Ser Glu Gly Ile 130 His Ph.
Lys Lys Leu 210 Asn Se r Met Cys Lys Leo Thr Ser Ser Ile Pro Gin Sen Ala Ile 195 Phe Gin Ala Ser Gly Glu Leo Leo Thr Phe 100 Cys Phe Ile Asp Leo 180 Val1 Gly Thr Phe His Asp Vat Glu Asn Ite Lys Thr Val Ile His 165 Val1 Gin Glu Leo Ala 245 Asp Ile Ser Arg Ala 70 dly Lys Leo Gly Met 150 Val1 Lys Vat Glu Gty 230 Pro Vat Gin Ala Ala 55 Ile Lys Ala Pro His 135 Met Pro Phe Cys Asp 215 Phe As n Gly Leo 40 As n Ala Val1 Cys Ile 120 Thr Leo Leo Leo Gly 200 G bo Glu Lys Vat 25 Cys Gin Ile Sen G to 105 Asn Asp Gly Ser Leo 185 Phe Lys Cys Arg Gly Glu Leo Asp Thr 90 Leo Lys Phe Cys Ala 170 Ala Asn Ile Phe Lys 250 Leo Pro Leo Ala 75 Gin Ala Leo Leo Ser 155 Val1 Phe Pro Leo Leu 235 Ile Leo Glu Leo Asp Pro Ser Asp Ala Lys 140 Lys Ser Gin His Lys 220 Gly Thr Lys Leo Tyr Asn Leo Gly Ser Try, 125 Gin Leu Gin Lys Ala 205 Ala Pro Pro Ala Ile Leo Ala Pro Ala Lys 110 Gin Arg Ph.
Leo Ser 190 Gly Ilte Leo Phe Leo Ile Leo Val1 Tyr Leo Tyr Glu Gin Tyr Vat Ile 175 Thr G lu Gin Pro Tyr 255 Tyr Ala Lys His Glu Leo Sen Val1 Ala Lys Gly 160 Gin Gtn Gbu Glu Ala 240 Val1 Ph.
CQ
""VT O Gly Leo Ala Pro 1268 260 265 270 Asp Giu Ser Ile Asn Val Ser Leu Asn Ala Pro Ile Leu Arg 275 280 285 Thr Asp His Gly Thr Ala Phe Asp Ile Ala Tyr Gin Asn Lys 290 295 300 His Lys Ser Tyr Leu Asn Ala Ile Lys Tyr Leu Ala 305 310 315 INFORMATION FOR SEQ ID NO:1729: SEQUENCE CHARACTERISTICS: LENGTH: 354 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...354 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1729 PCT/US 96/091 2 PENUP I DEC 1996 Ala Ser Ala Asn Gin Gly Ile Ile Gin Ala Lys Thr Pro Pro Lys Asp Lys Asp 1 Leu Ile His His Asn Gly Ser His Ser 145 Asp Gly Gly Glu Phe 225 Asn Phe Ser Glu His Ala Lys Leu Leu Val 130 Val Tyr Glu Gly Pro 210 Ser Ala Gin Ile Asp Ser Glu Asp Ser Ser 115 Tyr Leu Glu Ser Pro 195 Leu Phe His Ser 3lu kla Ser Asn Phe Val 100 Leu Ser Leu Asp Phe 180 Ile Met Set Asr Ala 5 Ser Lys Tyr Leu Ser Thr Asn Leu Val Ile 165 Asp Val Phe Gly n Leu 245 a Ala Ser Leu Gly Pro 70 Lys Leu Leu Phe Ser 150 Lys Lys Glu Pro Leu 230 Asn Ile Cys Ile Gly 55 Leu Ile Ile Pro Ile 135 Gly Ile Val Lys Ile 215 Lys Asp Asp Ala 1 40 Val Leu I Lys Glu Leu 120 Asn Gly Val Ser Leu 200 Pro Asn Glu Asp 25 His Val Leu Ala Gly 105 Ile Glu His Ala Lys 185 Ala Leu Ala Va 10 Ser Phe Pro Glu lie 90 Leu Leu Lys Ser Thr 170 Met Leu Lys Val L Lys 250 c
I
Ser Leu Ala Leu Met Ile Thr Arg Lys Ile Ser Gln Glu Lys Glu Ile Ala S Arg Val Lys 75 Ala Ile Thr Met Met Ala Glu Asp His 125 Gin Thr Arg 140 Leu Ile Leu 155 Ser Leu Asp Leu Asp Leu Asp Tyr Ala 205 Asn Ser Pro 220 Arg Leu Glu 235 Gin Lys Ile er Ile Asn Lys 110 Leu Met Glu Asp Gly 190 His Asr Val Gli Arg I Ser I Gin 3 Ala I Arg Pro Ala Ser 175 Tyr Pro Leu L Glu y Tyr 255 jeu Leu Pro Leu Gly Leu Arg 160 Phe Pro Asn Ala Lys 240 His Glu His Leu Ile Gln Gln Thr 265
L,
9 Phe Lys Ile L 275 "S 0 260 Lys Arg Tyr 270 Gly Ala Ser Lys Arg Pro Lys Phe Gly Ile Val Gly 285 Gin Asp 305 Ala Ile Phe 1269 Asn Leu Ala Leu Arg Lys Ala Phe Glu Asp Leu Cys Ala Glu Phe 290 295 300 Cys Glu Leu Val Leu Ala Pro Leu Glu Phe Cys Ser Asp Asn Ala 310 315 320 Met Ile Gly Arg Ser Ser Leu Glu Ala Tyr Gln Lys Lys Arg Phe 325 330 335 Pro Leu Glu Lys Ala Asp Ile Ser Pro Arg Thr Leu Leu Lys Asn 340 345 350 Glu INFORMATION FOR SEQ ID NO:1730: SEQUENCE CHARACTERISTICS: LENGTH: 256 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_£feature LOCATION 1...256 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1730 Arg Asn Asn Met Ala Tyr Lys Tyr Asp Gin Leu Glu Ser Ser Asp Gly Glu Ala Lys Lys Gin Asp Asp 145 Lys Ala Gin Lys Tyr Glu Gly Leu Asn Glu 130 Asn Met Val Val Asp Lys Glu Glu Lys Met 115 Glu Leu Gly Ala Leu 195 Gly Arg Leu Gly Val 100 Leu Val Asn Gly Lys 180 Thr Glu His Gin Val Asn Ser Lys Arg Phe 165 Thr Arg Lys Gly Tyr 70 Leu Tyr Lys Glu Gin 150 Lys Ile Thr Leu Leu Arg His 40 Asp Asp 55 Tyr Gly Tyr Lys Asn Lys Ile Leu 120 Met Cys 135 Ala Leu Ser Tyr Leu Gly Leu Ser 200 Thr Ala 215 Cys Ile Asp 25 Asn Tyr Ser Glu Lys 105 Glu Asp Ser Gin Arg 185 Phe Ile Val Arg Asp Leu C Leu Phe Glu Glu Lys Leu Ala Lys Tyr 3 Asn Ser Phe 75 Ile Leu Cys 90 Thr Glu Thr Arg Ser Leu Glu Leu Ser 140 Ala Ala Thr 155 Leu Ala Val 170 Gly Leu Ser Leu Thr Gly Asp Ile Ala 220 Val Ala Thr 235 ;1u Phe Leu Lys al I 3 hr Ala C Ala Asp Thr Glu 125 Ile Leu Ile Leu Pro 205 Gly Leu Leu 0 Ser lu Ser Val Leu 110 Glu Lys Thr Val Ala 190 Val Pro Arg Val P Ser Arg I Phe Cys Ile Met Asn Leu Ala 175 Gly Gly Ala Leu x Ser 255 >he Ile Ile Ile Asp Glu Asp Thr Phe 160 Asn Asn Trp Tyr Lys 240 Val Ile Ile Thr Gly Val Trp 210 Arg 225 Thr Val Thr Ile Pro Ala 230 Gin Gin Ala Glu Asp Lys Lys Ser 250 Leu Gin lie G1l PCT/US 9 6 091 2 1270 INFORMATION FOR SEQ ID NO:1731: SEQUENCE CHARACTERISTICS: LENGTH: 101 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...101 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1731 Val Ile Ile Phe Leu Leu Leu Phe Phe Leu Gly Asn Lys Val Phe Ser 1 5 10 Ile Tyr Leu Leu Leu Glu Ser Phe Leu Trp Val Ile Leu Thr Thr Trp 25 Cys Cys Leu Val Met His Glu Asp Gin Arg Gin Lys Asp Met Glu Gin 40 Leu Ile Asn Gly Ile Asp Arg Ile Ile Lys Ala Asn Ser Gly Lys Ser 55 Leu His Gln Glu Thr Gin Gin Ala Asn Lys Thr Asp Lys Ala Trp Asp 70 75 Leu Ala Ala Asn Val Phe Leu Ile Gly Leu Val Val Leu Ala Val Phe 90 His Met Ile Lys Arg 100 INFORMATION FOR SEQ ID NO:1732: SEQUENCE CHARACTERISTICS: LENGTH: 118 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION 1...118 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1732 Ala Val Lys Lys Val GIu Ser Met Asn Val Val Pro Phe Ile Asp Ile 1 5 10 Met Leu Val Leu Leu Val Ile Val Leu Thr Thr Ala Ser Phe Val Gin 25 Thr Ser Lys Leu Pro Ile Ser Ile Pro Gin Val Asp Lys Asp Ser Thr 40 Asp Ser Lys Asp Val Leu Asp Lys Lys Gin Val Thr Ile Ala Ile Ser N 50 55 ~NTO« AEN'02 SHEET: PCT/US 96/09122 IPAUS 16 DEC 1996 1271 Asn Lys Gly Ser Phe Tyr Phe Asp Asp Lys Glu Ile Ser Phe Glu Asn 70 75 Leu Lys His Lys Val Ser Thr Leu Ala Lys Asp Thr Pro Ile Val Leu 90 Gin Gly Asp Lys Lys Ser Asn Leu Asp Asn Phe Ile Lys Val Val Asp 100 105 110 Leu Leu Gln Leu Thr Ile 115 INFORMATION FOR SEQ ID NO:1733: SEQUENCE CHARACTERISTICS: LENGTH: 112 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION 1...112 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1733 Leu His Arg Gln Ala Gln Val Arg Ile Ser Leu Thr Gln Thr Thr Thr 1 5 10 Leu Val Ala Thr Ile Gly Ser Asn Ala Pro Tyr Ile Gly Leu Leu Gly 25 Thr Val Met Gly Ile Met Leu Thr Phe Met Asp Leu Gly Ser Ala Ser 40 Gly Ile Asp Thr Lys Ala Ile Met Thr Asn Leu Ala Leu Ala Leu Lys 55 Ala Thr Gly Met Gly Leu Leu Val Ala Ile Pro Ala Ile Val Ile Tyr 70 75 Asn Leu Leu Val Arg Lys Ser Glu Ile Leu Val Thr Lys Trp Asp Ile 90 Phe His His Pro Val Asp Thr Gln Ser His Glu Val Tyr Ser Lys Ala 100 105 110 INFORMATION FOR SEQ ID NO:1734: SEQUENCE CHARACTERISTICS: LENGTH: 139 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION 1...139 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1734 aucvnrn PGT/US 96/091 2 1272 Asn His Lys Ile Arg Gly Tyr Glu Lys Arg Met Ala Leu Asp Lys Arg 1 5 10 Ile Trp Met His Phe Asp Leu Leu Pro Phe Val Phe Ile Ile Pro Leu 25 Leu Val Val Ser Phe Leu Leu Ile Phe Glu Ser Ser Ala Val Leu Ser 40 Leu Lys Gln Gly Val Tyr Tyr Ala Ile Gly Phe Leu Leu Phe Trp Val 55 Val Phe Phe Ile Pro Phe Arg Lys Leu Asp Arg Trp Leu Phe Ala Leu 70 75 Tyr Trp Ala Cys Val Ile Leu Leu Ala Leu Val Asp Phe Met Gly Ser 90 Ser Lys Leu Gly Ala Gln Arg Trp Leu Val Ile Pro Phe Thr Ser Ile 100 105 110 Thr Leu Gln Pro Ser Glu Pro Val Lys Ile Ala Ile Leu Leu Leu Leu 115 120 125 Ala Arg Phe Asp Gln Asn Gln Pro Thr Ser Phe 130 135 INFORMATION FOR SEQ ID NO:1735: SEQUENCE CHARACTERISTICS: LENGTH: 310 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...310 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1735 Phe Cys Gly Thr Leu Lys Ala Leu Lys Ile Lys Ile Thr Thr Thr Pro 1 5 10 Cys Lys Ala Leu Lys Lys Lys Trp Lys Ile Leu Leu Lys His Leu Met 25 Lys Lys Lys Pro Leu Met Trp Arg Ile Cys Ala Leu Arg Arg Leu Leu 40 Leu Gly Phe Lys Arg Glu Arg Glu Leu Leu Ser Phe Ala Lys His Trp 55 Asn Ile Pro Thr Ile Val Val Phe Thr His Thr Gin Ala Glu Ala Gly 70 75 Asp Ala Phe Val Gln Glu Thr Lys Gly Ile Ile Asp Glu Glu Trp Gly 90 Phe Lys Gly Phe Val Arg Ala Tyr Val Arg Val Asn Ser Val Ala Phe 100 105 110 Ser Phe Arg Gly Leu Lys Val Pro Val Glu Gly Leu Glu Glu Leu Val 115 120 125 Asp Glu Thr Lys Lys Cys Leu Ser Asp Ala Glu Lys Asn Lys Lys Arg 130 135 140 His Phe Leu Ser Ile Gin Arg Val Lys Ile Gin Glu Arg Lys Gin Ala 145 150 155 160 Met Ile Glu Glu Cys Lys Thr Ile Ile His Val Ala Ser Gly Ala Ala 165 170 175 Gly Val Ala Gly Leu Ile Pro Ile Pro Phe Ser Asp Ala Leu Ala Ile 180 185 190 P I EIPciS 1D EC 19896 Gdy Se r Ala 230 Val1 Gly Giu Leu Pro 310 1273 Met Asn Leu Val 220 Thr Leu 235 Ala Gly Tyr Leu Asn Leu Tyr Leu 300 INFORMATION FOR SEQ ID NO:1736: SEQUENCE CHARACTERISTICS: LENGTH: 419 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc-feature LOCATION .419 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1736 Met Arg Sen Trp Met Lys Lys Lys Tyr Ph. Thr Leu Leu Leu Gln Sen
I
Ser Thr Val1 Glu Tyr Asn Ser Leu Sen 145 Ser As n SPhe Val1 Phe Val Trp Arg Pro Tyr Ser 130 Val1 Pro Lys Val1 Val1 Ser His Ser Leu Tyr Thr 115 Glu Phe His Asp Glu Leu Ala Ser Lys Lys Ala 100 Tyr Pro Ala Pro Giy 180 Phe 5 Ala Leu Ile Val1 Lys Thr Gin Ile Ser As n 165 Lys Phe Val1 Sen Lys Ala 70 Asp His Leu Leu Leu 150 Pro Ph.
Asp Phe Asn Thr 55 Asp Sen Tyr Ala Val1 135 Giu Ser Leu Lys Ile Gin 40 Ile Thr Lys Tyr Thr 120 Lys Tyr Val1 Asn Asp 200 10 Gly Cys 25 Glu Asn Asn Asp Tyr Asp Leu Lys 90 Asp Giu 105 Tyr Lys Thr Ser Pro Lys Sen Lys 170 Val Gly 185 Leu Giu Ser Thr Vali Ile 75 Ang Gly Gly Ph.
Sen 155 Tyr Sen Asp Sen Asp Ile Leu Asp Ile 140 Val1 Ile Thr Asp Ser Gly Aia G iu Lys 125 Asn Lys Ile Arg Lys Val1 Phe Thr Thr 110 Ile Pro Val1 Gin As n Asn Leu Gly Val1 Ile Glu Ser Val Phe Arg 175 *Ang His Pro Phe Leu Lys Ser Lys Glu Trp 160 Gin Leu Aia Val Lys Asp Gly Gin Lys Tyr Arg 205 195 Gln Ilie Ile Ala Giu Asn Ph. Met Gly Asp Lys Ser Arg Pro Ser PCTPJS 9 V2 1274 210 215 220 Val Ilie Val Giu Gly Lys Thr LYS Asp Leu Pro Lys Glu Ile Ala Asn 225 230 235 240 Val Arg Val Ser Gin Asn Leu Thr Arg Gin Ile Giu Leu Ser Trp Asp 245 250 255 Lys Ser Pro Glu Glu Asp Val Ile Ala Tyr Arg Ile Tyr Ala Ser Asn 260 265 .270 Asn Arg Asn Asp Lys Tyr Lys Phe Ile Ala Gin Thr Thr Asn Thr Ser 275 280 285 Tyr Val Asp Lys Ile Giu Lys Asp Asn Leu Thr Arg Tyr Tyr Lys Val 290 295 300 Val Ala Val Asp Lys Thr His Leu Giu Gly Ala Leu Pro Lys Giu Pro 305 310 315 320 Ala Met Gly Giu Thr Ser Asp Arg Pro Giu Ala Pro Ile Ile Thr Lys 325 330 335 Gly Thr Ile Gin Asp Ser Ser Ala Leu Ile Gin Trp Glu Asn Asn Pro 340 345 350 Ser Pro Lys Ile Aia Thr Tyr Ala Val Tyr Arg Phe Giu Ala Asn Ser 355 360 365 Lys Thr Pro Leu Arg Phe Giy Asn Ile Thr Gin Asn Gin Phe Val Asp 370 375 380 Lys Asp Met Lys Vai Giy Val Ala Tyr Arg Tyr Gin Vai Val Ser Vai 385 390 395 400 Asp Lys Asp Giy Leu Giu Ser His Pro Ser Lys Giu Val Arg Leu Phe 405 410 415 Leu Giu Arg INFORMATION FOR SEQ ID NO:i737: SEQUENCE CHARACTERISTICS: LENGTH: 260 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyiori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .260 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1737 Leu Lys Asn Thr Leu Lys Gly Leu Leu Met Leu Asp Phe Asp Lou Val 1 5 10 1s Leu Phe Gly Ala Thr Gly Asp Leu Ala Met Arg Lys Leu Ph. Val Ser 25 Leu Tyr Giu Ile Tyr Ilie His Tyr Gly Phe Lys Asn Asp Ser Arg Ile 40 .le Aia Ser Gly Arg Lys Glu Leu Ser Asn Glu Giu Phe Leu Ala Leu so 55 Leu Cys Giu Lys Thr Gin Leu His Ser Arg Glu Lys Giy Glu Glu Phe 70 75 Leu Thr His Ile Ser Tyr Lou Arg Val Arg Leu Asp Asn Pro Lys Asp 90 Phe Glu Glu Leu Ser Lys Ile Ala Thr Asn Asn Lys Pro Leu Ile Phe 100 105 110 Tyr Phe Ser Ile Ser Pro Ser Phe Phe Ala Thr Thr Ala Gin Asn Leu 115 120 125 1275 Ala Gin Asn Ala Leu Asn His Ala Asn Thr Arg Leu Ile Leu Glu Lys 130 135 140 Pro Leu Gly His Asp Leu Lys Thr Cys Lys GIu Ile Phe Gln Ser Ile 145 150 155 160 Ser Ala Phe Phe Lys Glu Glu Gin Ile Phe Arg Ile Asp His Tyr Leu 165 170 175 Gly Lys Lys Gly Val Gin Asn Ile Leu Glu Leu Arg Leu Asn Asn Pro 180 185 190 Ile Leu Asn Ile Leu Trp Asp Gin Ile Ser Ala Val Glu Ile Cys Val 195 200 205 Tyr Glu Thr Leu Gly Val Glu Glu Arg Gly Glu Phe Tyr Asp Lys Ile 210 215 220 Gly Ala Leu Arg Asp Met Val Gln Asn His Leu Leu Gin Val Leu Ser 225 230 235 240 Leu Ile Ala Thr Asp Leu Pro Asn Asp Leu Lys Asp Leu Arg Gin Glu 245 250 255 Lys Ser Lys Phe 260 INFORMATION FOR SEQ ID NO:1738: SEQUENCE CHARACTERISTICS: LENGTH: 346 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...346 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1738 Gly Met Val Lys His Tyr Leu Phe Met Ala Val Ser Gin Val Phe Phe 1 5 10 Ser Phe Phe Leu Val Leu Phe Phe Ile Ser Ser Ile Val Leu Leu Ile 25 Ser Ile Ala Ser Val Thr Leu Val Ile Lys Val Ser Phe Leu Asp Leu 40 Val Gin Leu Phe Leu Tyr Ser Leu Pro Gly Thr Thr Phe Phe Ile Leu 55 Pro Ile Thr Phe Phe Ala Ala Cys Ala Leu Gly Leu Ser Arg Leu Ser 70 75 Tyr Asp His Glu Leu Leu Val Phe Phe Ser Leu Gly Val Ser Pro Lys 90 Lys Met Thr Lys Ala Phe Val Pro Leu Ser Leu Leu Val Ser Ala Ile 100 105 110 Leu Leu Ala Phe Ser Leu Ile Leu Ile Pro Thr Ser Lys Ser Ala Tyr 115 120 125 Tyr Gly Phe Leu Arg Gin Lys Lys Asp Lys Ile Asp Ile Asn Ile Arg 130 135 140 Ala Gly Glu Phe Gly Gin Lys Leu Gly Asp Trp Leu Val Tyr Val Asp 145 150 155 160 Lys Thr Glu Asn Asn Ser Tyr Asp Asn Leu Val Leu Phe Ser Asn Lys 165 170 175 Ser Leu Ser Gln Glu Ser Phe Ile Leu Ala Gin Lys Gly Asn Ile Asn IAL 1 180 185 190 -'\Asn Gin Asn Gly Val Phe Glu Leu Asn Leu Tyr Asn Gly His Ala Tyr kt 72 C-IK-71T PGT/US 9 6/ 0912.2a 1276 Phe Leu 225 Gin Ala Leu Asn Val1 305 Leu Leu Thr 210 Arg Gly Asn Phe Pro 290 Gly Met Phe 195 Gin Asfl Thr Lys Pro 275 Arg Val Thr Arg Gly Lys Asp Asn 260 Leu Phe Tyr Ph.
Lys 340 Asp Leu 245 Gin Ala Lys Ph.
Phe 325 Phe Lys Lys 230 Leu Lys Ser Thr Leu 310 Ph.
Ile Met 215 Ser Gly Arg Val1 Asn 295 Met Pro Leu 200 Arg Phe Arg Ph.
280 Trp Val1 Ph.
Lys Lys Asn Trp Phe 265 Leu Ser His Ile Arg 345 Val1 Ser Lys 250 Ser Ile Tyr Val.
Trp 330 Asp As n 235 Lys Gin Pro Ph.
Ile 315 Ala Ph.
220 Asp Ala Ala Leu His 300 Ser Ph.
205 G Iu Ala Phe Ile Ph.
285 Val1 Thr Ile Giu Ala G ly Leu 270 Gly Leu Asp Ser Leu Tyr Lys 255 Val Ile Gly Leu Tyr 335 INFORMATION FOR SEQ ID NO:1739: SEQUENCE CHARACTERISTICS: LENGTH: 615 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .615 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1739 Ile Lou Ile Glu Gly Val Ph. Met Pro Lys Giu Lys Ile Thr Glu Arg Ser Lys Lys His Ser Leu Glu Gin 10 Lys Thr Arg Glu Leu Tyr Ile Leu GiU Cys Met Tyr Leu Ser Met Val1 145 Cys Asn Ala Pro Asn Ile Gly Glu 130 G ly Asp Thr Asri Leu Asp Lys Val1 115 Lou Leu Lys Phe Ile Gly Met Lys 100 Pro Sen Sen Ile Ser 180 Ala Ser Lou G lu Ala Leu Pro His His 70 Ser Leu Met Ph.
Asn Gin Pro Lys Ile Glu Ser Leu Gly Lys Val 55 Lys Ala Gin Cys Ser Thr Arg His Giu Asp 120 Arg Ala Lys Gin His 105 Gly Asp Ser His Pro 90 Asn Ile Val1 Gly M4et Ph.
75 Ph.
Ala Thr Ile Ala 155 Pro Glu His Ala Ile Ile Lys Asn Tyr Tyr Ala Ser 110 Gin Gly Tyr 125 Ala Lou Ser 140 Ph. Phe Lou Ala Leu Ser Leu Lys Thr Ala Pro Asp Val. Ala Glu Gly Thr Ala Gly Val 160 Phe Gly 175 Gly Ile 135 His Asn Val Phe Asp 150 Val Pro Gly Lou Lou Ile Gly 165 170 Asn Lou Ala Val Phe Val. Pro Ser Gly 185 Pro Met Val 6 /0 9196 1277 Gin Asp Phe Glu Ile Val 225 Met Asn Ala Ile His 305 Asn Lys Gly Phe Gin 385 Lys Ser Leu Lys Glu 465 Pro Thr Val Ile Lys 545 Val Glu Leu Met Asn Asn 210 Gly Glu Asn Ser Leu 290 Thr Trp Val Gly Glu 370 Asn Asp Glu Gly Val 450 Arg Phe Thr Thr His 530 Asp Leu Thr Phe Ser 610 Tyr 195 Arg Thr Phe Pro Gly 275 Asn Leu Asp Tyr Leu 355 Asp Tyr Ala Pro Arg 435 Lys Phe Gin Asn Asp 515 Leu Gly Glu Leu Thr 595 Phe Lys Lys Ala Lys Ala Arg 200 Glu Cys Met Leu 260 Lys Ala His Asp Pro 340 Ala Thr Thr Val Phe 420 Ala Ala Lys Gly Leu 500 Gly Ser Asp Lys Glu 580 Ser Gly Glu Thr Gly 245 Arg Val Leu Leu Phe 325 Asn Phe His Lys Ser 405 Ala Va 1 Arg Asn Pro 485 Gly Arg Pro Leu Asp 565 Asn Leu Ile Leu Phe 230 Leu Lys Leu Ile Ile 310 Asp Gly Val Thr Thr 390 His Ala Ile Ala Lys 470 Lys Ala Met Glu Ile 550 Phe Leu Arg Lys Leu 215 Tyr His Val Pro Gly 295 Ala Ala Ser Ile Ile 375 Pro Ser Asn Lys Ile 455 Glu Ser Leu Ser Gly 535 Glu Glu Glu Leu Val 615 Lys Gly Val Leu Leu 280 Leu Ile Ile Ala Lys 360 Met Phe Leu Gly Ile 440 Val Leu Asn Gin Gly 520 Ala Leu Lys Lys Asn 600 Val Thr Ala Val 265 Ala Met Ala Ser Asp 345 Glu Asp Leu Asn Gly 425 Ser Phe Glu Gly Asp 505 Ala Leu Asp Arg Pro 585 Ala Glu Ala Asn 250 Glu Lys Ala Arg Asn 330 Val Leu Thr Glu Thr 410 Leu Ala Lys Arg Met 490 Met Ser Asn Ala Gly 570 Thr Asn Met Asn 235 Ser Glu Leu Thr Ser 315 Leu Asn Leu Glu Asn 395 Asp Lys Ile Thr Asp 475 Pro Gly Gly Gly Pro 555 Ile Phe Thr Gin 220 Ser Ser Ser Ile Gly 300 Cys Ile Ala Lys Thr 380 Asp Ile Ile Lys Gin 460 Phe Glu Tyr Lys Ala 540 Asn Asn Gly Ala Ala 205 Ser Asn Phe Ala Asp 285 Gly Gly Pro Phe Glu 365 Gin Gin Leu Leu Asp 445 Ser Val Leu Lys Val 525 Ile Asn Pro Leu Glu 605 Met Tyr Gin Ile Lys 270 Glu Ser Val Leu Glu 350 Gly Lys Leu Arg Lys 430 Glu Glu Ala His Val 510 Pro Ile Ala Leu Gly 590 Glu Gly Lys His Asp Met Met 240 Asn Pro 255 Arg Leu Lys Ser Thr Asn Ile Leu 320 Leu Ala 335 Ala Cys Leu Leu Gly Met Val Tyr 400 Pro Val 415 Gly Asn His Arg Phe Leu Val Leu 480 Lys Leu 495 Ala Leu Ser Ala Lys Ile Leu Asn 560 Phe Leu 575 Arg Glu Gly Gly INFORMATION FOR SEQ ID NO:1740: SEQUENCE CHARACTERISTICS: LENGTH: 214 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein J. SET PCT/US 9 6 /091 IPEbuS 16 DEC 1996 1278 (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...214 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1740 Lys Tyr Lys Gly Asp Lys Met Gln Asp Lys Ile Ile Glu Ile Leu Gin 1 5 10 Ile Ser Pro Ile Val Pro Val Val Val Val Glu Asn Ile Lys Asp Ala 25 Val Pro Leu Ala Gin Ser Leu Ile Glu Gly Gly Ile Pro Ile Ile Glu 40 Val Thr Leu Arg Ser Asn Cys Ala Leu Glu Ala Ile GIu Leu Ile Ala 55 Lys Asn Val Pro Lys Met Arg Val Gly Ala Gly Thr Ile Leu Asn Leu 70 75 Thr Gln Leu Glu Gin Ala Gin Asn Arg Gly Ala Glu Phe Leu Ile Ser 90 Pro Gly Leu Thr Ile Lys Leu Leu Glu His Ala Lys Lys Lys Asp Met 100 105 110 Pro Leu Ile Pro Gly Val Ser Ser Ser Ser Glu Val Met Gin Ala Leu 115 120 125 Glu Leu Gly Tyr Asn Ala Leu Lys Phe Phe Pro Ala GIu Tyr Cys Gly 130 135 140 Gly Val Lys Leu Leu Asn Ala Phe Asn Gly Pro Phe Lys Gly Val Lys 145 150 155 160 Phe Cys Pro Thr Gly Gly Ile Ser Ala Asp Asn Met Arg Ser Tyr Leu 165 170 175 Ala Leu Glu Asn Val Val Cys Val Gly Gly Ser Trp Leu Thr Pro Lys 180 185 190 Asp Leu Ile Gln Asn Lys Glu Trp Asp Lys Ile Thr Glu Ile Cys Lys 195 200 205 Arg Ala Leu Ala Leu Arg 210 INFORMATION FOR SEQ ID NO:1741: SEQUENCE CHARACTERISTICS: LENGTH: 95 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION 1...95 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1741 Asn Thr Ala lie Val Ser Phe Leu Trp Phe Ala Tyr Val Ser Ile Gly 1 5 10 Leu Thr Asn Phe Val Ala Val Gly Tyr Met Val Ser Leu Leu Gly Ala 25 1279 Leu Lys Arg Thr Pro Cys Thr Asn Arg Phe Tyr Leu Lys Ala Leu Leu 40 Phe Ala Ile Phe Tyr His Ala Val Asn Asn Phe Leu Thr Gin Cys Pro 55 Pro His Gin Val Arg Giu Phe Phe Ser Ser Arg His Ala Gin Gly Trp 70 75 Lys Arg Glu Thr Leu Pro Cys Ala Leu Ser Phe Gin Asn Ala Leu 90 INFORMATION FOR SEQ ID NO:1742: SEQUENCE CHARACTERISTICS: LENGTH: 360 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc-feature LOCATION .360 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1742 Lys Lys Thr Pro Pro Ile Leu Cys Arg Leu Leu Gly Phe Tyr Ile Leu 1 5 10 Lys Lys Leu Pro Gin Arg Cys Phe Met Pro Lys Thr Glu Thr Tyr Pro 25 Arg Leu Leu Ala Asp Ile Gly Gly Thr Asn Ala Arg Phe Gly Leu Giu 40 Val Ala Pro Arg Gin Ile Giu Cys Val Giu Val Leu Arg Cys Glu Asp s0 55 Phe Glu Ser Leu Ser Asp Ala Val Arg Phe Tyr Leu Ser Lys Cys Lys 70 75 Giu Ser Leu Lys Leu His Pro Ile Tyr Gly Ser Phe Ala Vai Ala Thr 90 Pro Ile Met Gly Asp Phe Val Gin Met Thr Asn Asn His Trp Thr Phe 100 105 110 Ser Ile Giu Thr Thr Arg Gin Cys Leu Asn Leu Lys Lys Leu Leu Val 0115 120 125 le Asn Asp Phe Val. Ala Gin Ala Tyr Ala Ile Ser Ala Met Gin Giu 130 135 140 Asn Asp Leu Ala Gin Ile Gly Gly Ile Lys Cys Giu Ile Asn Ala Pro 145 150 155 160 Lys Ala Ile Leu Gly Pro Gly Thr Giy Leu Gly Val. Ser Thr Leu Ile 165 170 175 Gin Asn Ser Asp Gly Ser Leu Lys Val Leu Pro Asp Glu Gly Gly His 180 185 190 Val Sen Phe Ala Pro Phe Asp Asp Leu Glu Ile Leu Val Trp Gin Tyr 195 200 205 Ala Arg Ser Lys Phe Asn His Val Ser Ala Glu Arg Phe Leu Ser Gly 210 215 220 Ser Gly Leu Vai Leu Ile Tyr Glu Ala Leu Ser Lys Ang Lys Gly Leu 225 230 235 240 Glu Lys Val Ala Lys Leu Ser Lys Ala Giu Leu Thr Pro Gin Ile Ile 245 250 255 Sen Glu Ang Ala Leu Asn Gly Asp Tyr Pro Ile Cys Arg Leu Thr Leu (fRA44q 260 265 270 ApThr Phe Cys Sen Met Leu Gly Thr Leu Ala Ala Asp Val Ala Leu AT O ME 0rf! S, i"I PCT/US 96/0912 P S o DEC 1996 1280 275 280 285 Thr Leu Gly Ala Arg Gly Gly Val Tyr Leu Cys Gly Gly Ile Ile Pro 290 295 300 Arg Phe Ile Asp Tyr Phe Lys Thr Ser Pro Phe Arg Ala Arg Phe Glu 305 310 315 320 Thr Lys Gly Arg Met Gly Ala Phe Leu Ala Ser Ile Pro Val His Val 325 330 335 Val Met Lys Lys Thr Pro Gly Leu Asp Gly Ala Gly Ile Ala Leu Glu 340 345 350 Asn Tyr Leu Leu His Asp Arg Ile 355 360 INFORMATION FOR SEQ ID NO:1743: SEQUENCE CHARACTERISTICS: LENGTH: 340 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...340 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1743 Ser Gin Gly Leu Ile Phe Asp Lys Lys Lys Gln Lys Phe Leu Lys Asp 1 5 10 Phe Lys Ala Gly Glu Leu Leu Tyr Gln Ser His Phe Lys Pro Leu Val 25 Glu Phe Ile Ala Glu Glu Leu Leu Lys Asn Ser Arg Ala Lys Ile Ile 40 Gln Ser Asn Cys Asn Lys Ala Leu Lys Val Val Glu Glu Leu Gln Asn 55 Thr Ile Lys Thr Thr Ile Glu Lys Gin Ile Asn Pro Gly Met Lys Glu 70 75 Thr Gln Asp Pro Gln Gln Glu Ala Arg Phe Asn Leu Asp Arg Swr Thr 90 Asp Lys Phe lie Ser Asp Leu Glu Lys Ser Ala Phe Ser Lys Ile Asn 100 105 110 Gin Phe Giu Phe Asn Phe Arg Lys Glu Met His Glu Arg Ile Glu Arg 115 120 125 Gly Ile Gly Asn Asn Glu Cys Lys Glu Ile Phe Gly Asn Glu Leu Lys 130 135 140 Gin Arg Lys Thr Lys Leu Ile Glu Asp Ile Glu Arg Arg Phe Lys Glu 145 150 155 160 Cys Glu Glu Gln Phe Arg Gly Ser Val Gly Lys Asn Ile Glu Gln Leu 165 170 175 Glu Glu Arg Val Lys Asp Ser Leu Ala Ile Ile Lys Arg Ile Asn Asn 180 185 190 Leu Gly Leu Asn Pro Asn Ser Asn Phe Asn Met Asp Ser Gly Ile Asp 195 200 205 Thr Ile Gly Leu Phe Ser Ser Ile Gly Gly Leu Val Leu Leu Leu Leu 210 215 220 Thr Pro Val Val Gly Giu Phe Ala Leu Ile Ala Gly Val Gly Leu Ala 225 230 235 240 Leu Val Gly Val Gly Lys Ser Ile Trp Se r Phe Phe Asp Ser Asp Tyr 245 250 255 IPENUS ujL EC196 1281 Lys Lys Ser Gin Gin Arg Lys Glu Val Asp Lys Asn Leu His Gin Ile 260 265 270 Cys Glu Lys Ile Val Gin Asp Val Lys Ser Arg Ile Glu Ser Tyr Lys 275 280 285 Asn Gly Ala Leu Gly Met Ile Glu Glu Leu Asn Ala Gly Phe Asn Lys 290 295 300 Leu Val Asp His Tyr Glu Arg Met Lys Arg Gin Leu Glu Glu Ala His 305 310 315 320 Glu Lys Leu Gly Tyr Ile Tyr Asn Ser Ile His Leu Thr Ile Ser Asn 325 330 335 Arg Arg Ile Gin 340 INFORMATION FOR SEQ ID NO:1744: SEQUENCE CHARACTERISTICS: LENGTH: 219 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...219 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1744 Ser Ala Leu Trp His Lys Asp Pro Thr Thr Ile Lys Gin Phe Gly Leu 1 5 10 Glu Ala Leu Asp Phe Phe Lys Pro His Glu Ile Giu Leu Leu Ile Val 25 Ala Cys Asn Thr Ala Ser Ala Leu Ala Leu Glu Glu Met Gin Lys Tyr 40 Ser Lys Ile Pro Ile Val Gly Val Ile Glu Pro Ser Ile Leu Ala Ile 55 Lys Arg Gln Val Glu Asp Lys Asn Ala Pro Ile Leu Val Leu Gly Thr 70 75 Lys Ala Thr Ile Gin Ser Asn Ala Tyr Asp Asn Ala Leu Lys Gin Gin 90 Gly Tyr Leu Asn Ile Ser His Leu Ala Thr Ser Leu Phe Val Pro Leu 100 105 110 Ile Glu Glu Ser Ile Leu Glu Gly Glu Leu Leu Glu Thr Cys Met His 115 120 125 Tyr Tyr Phe Thr Pro Leu Glu Ile Leu Pro Glu Val Ile Ile Leu Gly 130 135 140 Cys Thr His Phe Pro Leu Ile Ala Gin Lys Ile Glu Gly Tyr Phe Met 145 150 155 160 Gly His Phe Ala Leu Pro Thr Pro Pro Leu Leu Ile His Ser Gly Asp 165 170 175 Ala Ile Val Glu Tyr Leu Gin Gln Lys Tyr Ala Leu Lys Asn Asn Ala 180 185 190 Cys Thr Phe Pro Lys Val Glu Phe His Ala Ser Gly Asp Val Ile Trp 195 200 205 Leu Glu Arg Gln Ala Lys Glu Trp Leu Lys Leu 210 215 INFORMATION FOR SEQ ID NO:1745: F S6/091? IPE UM 16 DEC 1996 1282 SEQUENCE CHARACTERISTICS: LENGTH: 109 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...109 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1745 Gly Ile Lys Leu Gly Gly Ile Asn Met Ala Gly Thr Gin Ala Ile Tyr 1 5 10 Glu Ser Ser Ser Ala Gly Phe Leu Ser Gln Val Ser Ser Ile Ile Ser 25 Ser Thr Ser Gly Val Ala Gly Pro Phe Ala Gly Ile Val Ala Gly Ala 40 Met Thr Ala Ala Ile Ile Pro Ile Val Val Gly Phe Thr Asn Pro Gin 55 Met Thr Ala Ile Met Thr Gln Tyr Asn Gin Ser Ile Ala Glu Ala Val 70 75 Ser Val Pro Met Lys Ala Ala Asn Gin Gln Tyr Ser Gin Leu Tyr Gin 90 Gly Phe Asn Asp Gln Ser Met Ala Val Gly Thr Ile Ser 100 105 INFORMATION FOR SEQ ID NO:1746: SEQUENCE CHARACTERISTICS: LENGTH: 122 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES of (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...122 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1746 Phe Gin Phe Glu Arg Lys Arg Met Lys Phe Phe Thr Arg Ile Thr Asp 1 5 10 Ser Tyr Lys Lys Val Val Val Thr Leu Gly Leu Val Val Thr Thr Asn 25 Pro Leu Met Ala Val Thr Ser Pro Ala Thr Gly Val Thr Glu Thr Lys 40 Ser Leu Val Ile Gin Ile Ile Ser Val Leu Ala Ile Val Gly Gly Cys 55 4 j\ Ala Leu Gly Val Lys Gly Ile Ala Asp Ile Trp Lys Ile Ser Asp Asp 70 75 AMENND SH1EET.
IPEAUS 1 o EC 1996 1283 Ile Lys Arg Gly Gin Ala Thr Val Phe Ala Tyr Ala Gin Pro Ile Ala 90 Met Leu Ala Val Ala Gly Gly Ile lie Tyr Leu Ser Thr Lys Phe Gly 100 105 110 Phe Asn Ile Gly GIu Ser Gly Gly Ala Ser 115 120 INFORMATION FOR SEQ ID NO:1747: SEQUENCE CHARACTERISTICS: LENGTH: 991 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...991 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1747 Ser Gly Ile Ser Ile Lys Arg Gly Val Phe Val Ala Ser Lys Gin Ala 1 5 10 Asp Glu Gin Lys Lys Leu Val Ile Glu Gln Glu Val Gln Lys Arg Gin 25 Phe Gln Lys Ile Glu Glu Leu Lys Ala Asp Met Gin Lys Gly Val Asn 40 Pro Phe Phe Lys Val Leu Phe Asp Gly Gly Asn Arg Leu Phe Gly Phe 55 Pro Glu Thr Phe Ile Tyr Ser Ser Ile Phe Ile Leu Phe Val Thr Ile 70 75 Val Leu Ser Val Ile Leu Phe Gln Ala Tyr Glu Pro Val Leu Ile Val 90 Ala Ile Val Ile Val Leu Val Ala Leu Gly Phe Lys Lys Asp Tyr Arg 100 105 110 Leu Tyr Gin Arg Met Glu Arg Ala Met Lys Phe Lys Lys Pro Phe Leu 115 120 125 Phe Lys Gly Val Lys Asn Lys Ala Phe Met Ser Ile Phe Ser Met Lys 130 135 140 Pro Ser Lys Glu Met Ala Asn Asp Ile His Leu Asn Pro Asn Arg Glu 145 150 155 160 Asp Arg Leu Val Ser Ala Ala Asn Ser Tyr Leu Ala Asn Asn Tyr Glu 165 170 175 Cys Phe Leu Asp Asp Gly Val Ile Leu Thr Asn Asn Tyr Ser Leu Leu 180 185 190 Gly Thr Ile Lys Leu Gly Gly Ile Asp Phe Leu Thr Thr Ser Lys Lys 195 200 205 Asp Leu Ile Glu Leu His Ala Ser Ile Tyr Ser Val Phe Arg Asn Phe 210 215 220 Val Thr Pro Glu Phe Lys Phe Tyr Phe His Thr Val Lys Lys Lys Ile 225 230 235 240 Val Ile Asp Glu Thr Asn Arg Asp Tyr Gly Leu Ile Phe Ser Asn Asp 245 250 255 Phe Met Arg Ala Tyr Asn Glu Lys Gln Lys Arg Glu Ser Phe Tyr Asp 260 265 270 Ile Ser Phe Tyr Leu Thr Ile Glu Gln Asp Leu Leu Asp Thr Leu Asn 275 280 285 Glu Pro Val Met Asn Lys Lys His Phe Ala Asp Asn Asn Phe Glu Glu IPEAIUS 1DUE i596 1284 290 295 300 Ph. Gin Arg Ile Ile Arg Ala Lys Leu Giu Asn Ph. Lys Asp Arg Ile 305 310 315 320 Glu Leu Ile Giu Glu Leu Leu Ser Lys Tyr His Pro Thr Arg Leu Lys 325 330 335 Giu Tyr Thr Lys Asp Gly Ile Ile Tyr Ser Lys Gin Cys Giu Phe Tyr 340 345 350 Asn Phe Leu Val Gly Met Asn Glu Ala Pro Phe Ile Cys Asn Arg Lys 355 360 365 Asp Leu Tyr Leu Lys Giu Lys Met His Gly Gly Val Lys Giu Val Tyr 370 375 380 Phe Ala Asn Lys His Gly Lys Ilie Leu Asn Asp Asp Leu Ser Glu Lys 385 390 395 400 Tyr Phe Ser Aia Ile Giu Ile Ser Glu Tyr Ala Pro Lys Ser Gin Ser 405 410 415 Asp Leu Phe Asp Lys Ile Asn Ala Leu Asp Ser Giu Phe Ile Phe Met 420 425 430 His Ala Tyr Ser Pro Lys Asn Ser Gin Val Leu Lys Asp Lys Leu Ala 435 440 445 Phe Thr Ser Arg Arg Ile Ile Ile Ser Gly Giy Ser Lys Giu Gin Gly 450 455 460 Met Thr Leu Gly Cys Leu Ser Giu Leu Val Gly Asn Gly Asp Ile Thr 465 470 475 480 Leu Gly Ser Tyr Gly Asn Ser Leu Val Leu Phe Ala Asp Ser Ph. Giu 485 490 495 Lys Met Lys Gin Ser Val Lys Giu Cys Vai Ser Ser Leu Asn Ala Lys 500 505 510 Gly Ph. Leu Ala Asn Ala Ala Thr Phe Ser Met Giu Asn Tyr Ph. Ph.
515 520 525 Ala Lys His Cys Ser Ph. Ile Thr Leu Pro Ph. Ile Ph. Asp Val Thr 530 535 540 Ser Asn Asn Ph. Ala Asp Ph. Ile Ala Met Arg Ala Met Ser Ph. Asp 545 550 555 560 Gly Lys Glu Asp Asn Asn Ala Trp Gly Asn Ser Val Met Thr Leu Lys 565 570 575 Ser Glu Ile Asn Ser Pro Ph. Tyr Leu Asn Ph. His Met Pro Thr Asp 580 585 590 Ph. Gly Ser Ala Ser Ala Gly His Thr Leu Ile Leu Gly Ser Thr Gly 595 600 605 Ser Gly Lys Thr Val Ph. Met Ser Met Thr Leu Asn Ala Met Gly Gin 610 615 620 Ph, Ala Tyr Asn Ph. Pro Ala Asn Ile Ser Lys Asp Lys Gin Lys Lou 625 630 635 640 Thr Met Val Tyr Met Asp Lys Asp Tyr Gly Ala Tyr Gly Asn Ile Val 645 650 655 Ala Met Gly Gly Glu Tyr Val Lys Ile Giu Lou Gly Thr Asp Thr Gly 660 665 670 Leu Asn Pro Ph. Ala Trp Ala Ala Cys Val Gin Lys Thr Asn Ala Thr 675 680 685 Met Giu Gin Lys Gin Thr Ala Ile Ser Val Val Lys Glu Leu Val Lys 690 695 700 Asn Leu Ala Thr Lys Ser Asp Giu Lys Asp Glu Asn Gly Asn Ser Ile 105 710 715 720 Ser Ph. Ser Lou Ala Asp Ser Asn Thr Leu Ala Ala Ala Val Thr Asn 725 730 735 Leu Ile Thr Gly Asp Met Asn Leu Asp Tyr Pro Ile Thr Gin Leu Ile 740 745 750 Asn Ala Ph. Gly Lys Asp His Asn Asp Pro Asn Gly Leu Val Ala Arg 755 760 765 Leu Ala Pro Ph. Cys Lys Ser Thr Asn Gly Glu Ph. Gin Trp Leu Ph.
770 775 780 Asp Asn Lys Ala Thr Asp Arg Leu Asp Ph. Ser Lys Thr Ile Ile Gly 785 790 795 800 ~Ai'Val1 Asp Giy Ser Ser Ph, Leu Asp Asn Asn Asp Val Ser Pro Phe Ile 805 810 815 AfAu IPEAIS 180EC 1996 1295 Cys Phe Val1 Ala 865 Pro Arg Thr Leu Arg 945 Phe Phe Val1 Ala 850 Ile Ile Asn Giu Tyr 930 Gly Val1 Leu 820 Asp Phe Arg Asp dly 900 Giu Gin Pro Giu Ph.
Ile Val1 Leu Thr 885 Gly Phe Asp Lys Ile 965 Ala Asp Arg Ala 870 Ile Asn Giu G ly Giu 950 Asp Arg Giu Asp 855 Thr Arg Leu Ile Ser 935 Lys Ile Ala 840 Met Gin Giu Ser Ile 920 Pro Leu Ile Gin 825 Trp Leu Ser Gin Asp 905 Thr Ser Lys Ile Tyr 985 Giu Lys Lys Ile Cys 890 Tyr Lys Val Ile Gin 970 Ala Tyr Thr Thr 875 Pro Gin Gly Ile Leu 955 As n Met Leu Ala 860 Asp Thr Arg Leu Ala 940 Ser His Asp Giy 845 Arg Leu Lys Leu Asp 925 Ser Thr Ser Gly 830 Asp Lys Leu Ile Ala 910 Arg Phe Asp Ile Arg Pro Arg Ala Phe 895 As n Lys Asn Thr Ile 975 Arg Lys Asn Cys 880 Leu Val1 Ile Leu Val 960 Asp Lys Tyr Gin Ala Leu Arg Gin Met Gln Gin Ile Lys Giu Tyr 990 INFORMATION FOR SEQ ID NO:i748: SEQUENCE CHARACTERISTICS: LENGTH: 1183 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc..feature LOCATION .1183 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:i748 Phe Leu Vai Ala Leu Met Ile Pro Asn Leu Asp Ile Giu Met Asn Asp Lys Arg Gin Asp Giy Asp 145 R4 Ile %bK, U-
LU'
T 0<O Asn Gin Val1 Asp Giu Phe Leu 115 Gin Ser Gin GlU Gin Val Arg Phe Sen 100 Ile Ang Lys Pro Aia Ph.
Aia Asp Ala Sen Asp Tyr Ile Pro Ile Ile Ser Asn 70 Asn Phe Thr Gin As n 150 Ile Asn Asn Phe Arg Lys Ile Gly Ile 135 Thr Ser Thr Aia Lys Lys Pro Asp Sen Val1 140 Giy Lys Giu Ph.
Pro Ile Thr Leu Ph.
125 Sen Phe Ala Giy Aia Ile Ile Ser Lys Ile 110 Gin His Met Giu Giu Thn is Ala Phe Lys Vai Val Asp Gin Leu Lys Asri Asp Lys Lys Phe Gin Asn Giu Asn 160 Phe Leu A tv Z -4 JfkAIUS 1ij LEC 1996 1286 165 170 175 Arg Ser Ala Lys Gin Ala Phe Ala Gly Ile Ile Ile Gly Asn Gln Ile 180 185 190 Arg Ser Asp Gin Lys Phe Met Gly Vai Phe Asp Glu Ser Leu Lys Glu 195 200 205 Arg Gin Glu Ala Giu Lys Asn Gly Glu Pro Asn Giy Asp Pro Thr Gly 210 215 220 Gly Asp Trp Leu Asp Ile Phe Leu Ser Phe Val Phe Asn Lys Lys Gin 225 230 235 240 Ser Ser Asp Leu Lys Glu Thr Leu Asn Gin Glu Pro Val Pro His Val 245 250 255 Gin Pro Asp Val Ala Thr Thr Thr Thr Asp Ile Gin Ser Leu Pro Pro 260 265 270 Glu Ala Arg Asp Leu Leu Asp Glu Arg Gly Asn Phe Ser Lys Phe Thr 275 280 285 Leu Gly Asp Met Asn Met Leu Asp Val Glu Gly Val Ala Asp Ile Asp 290 295 300 Pro Asn Tyr Lys Pho Asn Gin Lou Leu Ile His Asn Asn Ala Leu Ser 305 310 315 320 Ser Val Leu Met Gly Ser His Asn Gly Ile Glu Pro Glu Lys Val Ser 325 330 335 Leu Leu Tyr Gly Asn Asn Gly Giy Pro Giu Ala Arg His Asp Trp Asn 340 345 350 Ala Thr Val Gly Tyr Lys Asn Gin Arg Gly Asp Asn Val Ala Thr Leu 355 360 365 Ile Asn Val His Met Lys Asn Giy Ser Gly Leu Val Ile Ala Gly Gly 370 375 380 Giu Lys Giy Ile Asn Asn Pro Ser Phe Tyr Leu Tyr Lys Giu Asp Gin 385 390 395 400 Leu Thr Gly Ser Gin Arg Ala Leu Ser Gin Glu Glu Ile Gin Asn Lys 405 410 415 Val Asp Phe Met Giu Phe Lou Ala Gin Asn Asn Ala Lys Leu Asp Asn 420 425 430 Leu Ser Lys Lys Giu Lys Giu Lys Phe Gin Asn Giu Ile Giu Asp Phe 435 440 445 Gin Lys Asp Ser Lys Aia Tyr Lou Asp Aia Lou Gly Asri Asp His Ile 450 455 460 Ala Phe Val Ser Lys Lys Asp Lys Lys His Leu Ala Leu Val Ala Giu 465 470 475 480 Phe Giy Asn Gly Giu Lou Sor Tyr Thr Lou Lys Asp Tyr Gly Lys Lys 485 490 495 Ala Asp Lys Ala Lou Asp Arg Giu Ala Lys Thr Thr Lou Gin Giy Ser 500 505 510 Leu Lys His Asp Gly Val Met Phe Val Asp Tyr Sor Aen Phe Lys Tyr 515 520 525 Thr Asn Ala Ser Lys Ser Pro Asp Lys Gly Val Gly Ala Thr Asn Gly 530 535 540 Val Ser His Lou Giu Ala Gly Phe Ser Lys Val Ala Val Phe Asn Lou 545 550 555 560 Pro Asn Lou Asn Asn Leu Ala Ile Thr 5cr Val Val Arg Gin Asp Lou 565 570 575 Giu Asp Lys Leu Ile Ala Lys Gly Lou Ser Pro Gin Glu Ala Asri Lys 580 585 590 Lou Val Lys Asp Phe Leu Ser Ser Asn Lys Giu Lou Val Gly Lye Ala 595 600 605 Lou Asn Phe Asn Lys Ala Val Ala Giu Ala Lys Asn Thr Gly Asri Tyr 610 615 620 Asp Giu Val Lys Gin Ala Gin Lys Asp Lou Glu Lys Sor Lou Lys Lys 625 630 635 640 Arg Giu Arg Leu Giu Lys Asp Val Ala Lys Asn Lou Glu Ser Lys Ser 645 650 655 Gly Asn Lys Asn Lys Met Glu Aia Lye Ser Gin Ala Asn Ser Gin Lys 660 665 670 Asp Giu Ilie Phe Ala Lou Ile Asn Lye Giu Ala Asn Arg Asp Ala Arg 675 680 685 1< IP~NI1S 1DEC 1996 1287 Ala Ilie Ala Tyr Ala Gin Asn Leu Lys Gly Ile Lys Arg Giu Leu Ser 690 695 700 Asp Lys Leu Glu Asn Ile Asn Lys Asp Leu Lys Asp Ph. Ser Lys Ser 705 710 715 720 Phe Asp Giu Phe Lys Asn Gly Lys Asn Lys Asp Ph. Ser Lys Ala Glu 725 730 735 Giu Thr Leu Lys Ala Leu Lys Gly Ser Val Lys Asp Lou Gly Ile Asn 740 745 750 Pro Giu Trp Ile Ser Lys Val Glu Asn Leu Asn Ala Ala Leu Asn Glu 755 760 765 Phe Lys Asn Gly Lys Asn Lys Asp Phe Ser Lys Val Thr Gin Ala Lys 770 775 780 Ser Asp Leu Glu Asn Ser Ile Lys Asp Val Ile Ile Aen Gin Lys Ile 785 790 795 800 Thr Asp Lys Val Asp Asn Leu Asn Gin Ala Val Ser Val Ala Lys Ala 805 810 815 Thr Gly Asp Phe Ser Gly Val Giu Gin Ala Leu Ala Asp Leu Lys Asn 820 825 830 Phe Ser Lys Giu Gin Lou Ala Gin Gin Ala Gin Lys Asn Giu Asp Phe 835 840 845 Asn Thr Gly Lys Asn Ser Ala Lou Tyr Gin Ser Val Lys Aen Gly Val 850 855 860 Asn Gly Thr Lou Val Gly Asn Gly Lou Ser Lys Ala Glu Ala Thr Thr 865 870 875 880 Leu Ser Lys Asn Phe Ser Asp Ile Lys Lys Glu Leu Asn Ala Lys Leu 885 890 895 Gly Asn Phe Asn Asn Asn Asn Asn Asn Gly Leu Giu Aen Ser Thr Glu 900 905 910 Pro Ilie Tyr Thr Gin Val Ala Lys Lys Val Lys Ala Lys Ilie Asp Arg 915 920 925 Leu Asp Gin Ile Ala Ser Gly Leu Gly Asp Val Gly Gin Ala Ala Ser 930 935 940 Ph. Leu Leu Lys Arg His Asp Lys Val Asp Asp Lou Ser Lys Val Gly 945 950 955 960 Lou Ser Ala Asn His Glu Pro Ilie Tyr Ala Thr Ile Asp Asp Lou Gly 965 970 975 Gly Pro Phe Pro Lou Lys Arg His Asp Lys Val Asp Asp Lou Sor Lys 980 985 990 Val Gly Lou Sor Arg Giu Gin Lys Lou Thr Gin Lys Ile Asp Asn Leu 995 1000 1005 Asn Gin Ala Val Ser Giu Ala Lys Ala Ser His Ph. Asp Asn Lou Asp 1010 1015 1020 Gin Met Ilie Asp Lys Lou Lys Asp Ser Thr Lys Lys Asn Val Val Asn 1025 1030 1035 1040 Leu Tyr Val Giu Ser Ala Lys Lys Val Pro Thr Sor Leu Sor Ala Lys 1045 1050 1055 Leu Asp Asn Tyr Ala Thr Asn Ser His Thr Arg Ile Asn Ser Asn Val 1060 1065 1070 Lys Aen Gly Thr Ile Aen Giu Lye Ala Thr Gly Met Lou Thr Gin Lys 1075 1080 1085 Asn Ser Giu Trp Lou Lys Lou Val Asn Asp Lys Ile Val Aia His Asn 1090 1095 1100 Val Gly Ser Ala Pro Lou Ser Ala Tyr Asp Lys Ile Gly Ph. Aen Gin 1105 1110 ills 1120 Lye Asn Met Lye Asp Tyr Ser Asp Ser Pho Lye Pho Ser Thr Arg Lou 1125 1130 1135 Ser Aen Ala Val Lye Asp Ile Lys Ser Gly Ph. Val Gin Phe Lou Thr 1140 1145 1150 Asn Ile Phe Ser Mot Gly Ser Tyr Ser Leu Met Lye Ala Ser Val Glu 1155 1160 1165 His Gly Val Lye Asn Thr Asn Thr Lye Gly Gly Ph. Gin Lye Ser 1170 1175 1180 INFORMATION FOR SEQ ID NO:1749: 7V O) IPEA/US 1 DEC 1996 1288 SEQUENCE CHARACTERISTICS: LENGTH: 224 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...224 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1749 Ala Leu Ser Leu Ala Ser Ile Leu Ala Arg Val Glu 1 Leu Lys Asp Pro Thr Pro Val Lys Gin 145 Thr Glu Asn Ser Ile Val Asp Asn Ile Asp Leu Ile 130 Ile Thr Ile Ser Leu 210 Asn Leu Lys Gly Lys Ile Lys 115 Phe Asn Asn Leu Tyr 195 Lys Asn Leu Glu Leu Asn Ile 100 Lys Asp Pro Lys Cys 180 Asp Lys 5 Asn Ser Ala Val Leu Lys Ile Glu Glu Gin 165 Asp Pro Ile Lys Phe Ala Leu Lys Phe 105 Lys Glu Phe Leu Tyr 185 Leu Ile Lys Ser Leu Asp Val Asp His Met Phe Ser 170 Asn Lys Thr Leu Ser Glu Phe Thr Phe Tyr Gly Thr 155 Leu Val His Cys Glu Gly Gly Glu Ser Lys Ile Pro 125 Asn Lys Gly Leu Ser 205 Ala INFORMATION FOR SEQ ID NO:1750: SEQUENCE CHARACTERISTICS: LENGTH: 154 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: RA NAME/KEY: misc_feature
TI
IPEA1U3 DEC 1996 1289 LOCATION .154 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1750 Asn Ala Lys Asri Lys Asn Lys Gly Val Lys Ser As n 1h Phe Ser Gin Ile Ile Met~ Gly Ser 145 Tyr As n Pro Leu Leu Ser Trp Pro 130 Ser Lys Ala Giu Lys Asn Leu Gly 115 As n Phe Ile 20 Pro Asp Ile Asp Gly 100 Ile Asn Leu Lys Leu Met Giu Tyr Ser Gin Se r Pro Leu As n Ala Ile 70 Asn Phe As n Phe Pro iso Leu Ala Leu 55 Pro Asp Gin Leu Met 135 Ile Phe Asp 40 As n Lys Lys Pro Leu 120 Tyr Leu Ala 25 Gin Ser Giu Asn As n 105 Met Gly Gly Trp Asn Val1 Thr Val1 90 Asp Ser Tyr Cys Thr Gly Leu 75 Asn Asn Gin Ala Leu Asp Leu Giu Ile Leu Met Pro 140 Met Ile Ile Val1 Gin Lys Gly Met 125 Thr Lys Ile Lys Ser Lys Phe Ile 110 Ser Tyr Thr Gly Asp Arg Val1 Asp Asn As n Ser Asn Met Ile Asp Ala Asp Ala Tyr Asp INFORMATION FOR SEQ ID NO:i751: SEQUENCE CHARACTERISTICS: LENGTH: 518 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .518 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1751 Pro Pro Ile Ile Tyr Lys Ala Ile Gin Lys Leu Val Lys Ile Arg Leu Phe Asp Phe Thr Ile Asp His Ile Ser Leu Pro Giu Phe 135 G lu Phe Arg 40 Ala Asp Ala Asp Lys 120 Ala Ile Leu Lys Ala Ser Gin Phe 105 Ser Leu Arg Lys Tyr Gly Ala Giu Lys Ala Asp Lys Gly Leu Met Ala Tyr Giu Leu Leu Thr Arg Arg Val Gly Val Arg Thr Ser 125 Leu Val1 12 iT- "Ci 0 Z 1 n919 1290 145 150 155 160 Asp Gly Val Phe Asp Glu Gl>. -eu Tyr Lys Asn Ile Leu Lys Gln Ser 165 170 175 His Tyr Arg Pro Lys His Phe Glu Glu Ser Val Glu Arg Leu Leu Ile 180 185 190 Leu Gin Lys Ile Ser Ala Leu Phe Pro Lys Thr Thr Thr Pro Leu Glu 195 200 205 Gin Ser Ser Leu Ser Leu Trp Ala Lys Leu Gln Asp Lys Leu Asp Ile 210 215 220 Leu Ile Leu Asn Pro Asn Asp Val Lys Ile Ser Leu Asn Glu Glu Glu 225 230 235 240 Met Lys Lys Tyr Tyr Glu Asn His Arg Lys Asp Phe Lys Lys Pro Thr 245 250 255 Ser Phe Lys Thr Arg Ser Leu Tyr Phe Asp Ala Ser Leu Glu Lys Thr 260 265 270 Asp Leu Lys Glu Leu Glu Glu Tyr Tyr His Lys Asn Lys Val Ser Tyr 275 280 285 Leu Asp Lys Glu Gly Lys Leu Gln Asp Phe Lys Ser Val Gln Glu Gin 290 295 300 Val Lys His Asp Leu Asn Met Gln Lys Ala Asn Glu Lys Ala Leu Arg 305 310 315 320 Ser Tyr Ile Ala Leu Lys Lys Gly Asn Ala Gln Asn Tyr Thr Thr Gin 325 330 335 Asp Phe GIu Lys Asn Asn Ser Pro Tyr Thr Ala Glu Ile Thr Gln Lys 340 345 350 Leu Thr Ala Leu Lys Pro Leu Glu Val Leu Lys Pro GIu Pro Phe Lys 355 360 365 Asp Gly Phe Ile Val Val Gln Leu Val Ser Gln Ile Lys Asp Glu Leu 370 375 380 Gin Asn Phe Asp Glu Ala Lys Ser Ala Leu Lys Thr Arg Leu Thr Gin 385 390 395 400 Glu Lys Thr Leu Met Ala Leu Gln Thr Leu Ala Lys Glu Lys Leu Lys 405 410 415 Asp Phe Lys Gly Lys Ser Val Gly Tyr Val Ser Pro Asn Phe Gly Gly 420 425 430 Thr Ile Ser Glu Leu Asn Gln Glu Glu Ser Ala Lys Phe Ile Asn Thr 435 440 445 Leu Phe Asn Arg Gin Glu Lys Lys Gly Phe Val Thr Ile Gly Asn Lys 450 455 460 Val Val Leu Tyr Gin Ile Thr Glu Gln Asn Phe Asn His Pro Phe Ser 465 470 475 480 Ala Glu Glu Asn Gin Tyr Met Gln Arg Leu Val Asn Asn Thr Lys Thr 485 490 495 Asp Phe Phe Asp Lys Ala Leu Ile Glu Glu Leu Lys Lys Arg Tyr Lys 500 505 510 Ile Val Lys Tyr Ile Gin 515 INFORMATION FOR SEQ ID NO:1752: SEQUENCE CHARACTERISTICS: LENGTH: 157 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori A4 (ix) FEATURE: NAME/KEY: misc_feature
T
0 7 9 6 091 IPENUSl DC U 6 1291 LOCATION 1...157 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1752 Lys Gly Lys Leu Gly Leu Phe Tyr Tyr Phe Ser Asp Leu Leu Glu Ser 1 5 10 Leu Ile Cys Phe Ser Asn Ser Cys Cys Lys Ala Cys Cys Cys Phe Ser 25 Phe Phe Glu Arg Arg Arg Phe Phe Leu Gly Phe Phe Ser Phe Phe Glu 40 Glu Val Ser Gly Ser Phe Glu Ala Val Ser Leu Ser Val Leu Ala Leu 55 Val Ile Gly Ser Arg Ser Gly Leu Glu Glu Phe Cys Val Leu Glu Glu 70 75 Leu Ile Asn Ser Gly Leu Ser Val Trp Leu Ser Ser Ser Pro Leu Leu 90 Leu Phe Trp Asn Ala Ala Leu Val Ser Phe Ser Ala Cys Ser Ser Ile 100 105 110 Phe Leu Arg Thr Ile Ala Ser Thr Phe Leu Ala Phe Ser Phe Trp Leu 115 120 125 Thr Leu Thr Met Leu Ile Lys Tyr Leu Ile Tyr Pro Ser Tyr Met Ser 130 135 140 Pro Asn Cys Ser Cys Lys Ala Pro Lys Ser Glu Pro Leu 145 150 155 INFORMATION FOR SEQ ID NO:1753: SEQUENCE CHARACTERISTICS: LENGTH: 206 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...206 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1753 Gly Leu Leu Lys Pro Leu Glu Glu Thr Glu Ile Lys Ala Cys Asn Lys 1 5 10 Asp Ile Leu Pro Leu Lys Pro Tyr Glu Lys Ala Lys Leu Ile Ala Tyr 25 Ile Pro Gin Val Glu Tyr Tyr Ala Phe Asn Phe Ser Val Leu Asp Phe 40 Val Leu Met Gly Lys Ala Thr His Leu Asn Leu Phe Ala Met Pro Lys 55 Ala Lys His Ile Lys Glu Ala Thr Ser Val Leu Glu Arg Leu Asp Leu 70 75 Glu Ser Leu Lys Asp Gin Gly Ile Asn Asp Leu Ser Gly Gly Gin Arg 90 Gin Met Val Leu Leu Ala Arg Ser Leu Leu Gin Arg Thr Pro Leu Leu 100 105 110 Leu Leu Asp Glu Pro Thr Ser Ala Leu Asp Leu Lys Asn Gin Ala Leu 115 120 125 Phe Phe Asp Ala Ile Lys Asp Glu Met Lys Lys Arg Glu Leu Ser Val 130 135 140 Leu Val Asn Ile His Asp Pro Asn Leu Val Ala Arg His Ser Thr His AME:I:z IPEA/US 1 DEC 1996 1292 145 150 155 160 Val Val Met Leu Lys Asp Lys Lys Leu Phe Leu Gln Ala Ser Thr Pro 165 170 175 Ile Ala Met Thr Ser His Asn Leu Ser Ala Leu Tyr Asp Thr Pro Leu 180 185 190 Glu Ala Ile Trp His Asp Asp Lys Leu Val Val Tyr Ala Leu 195 200 205 INFORMATION FOR SEQ ID NO:1754: SEQUENCE CHARACTERISTICS: LENGTH: 113 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION 1...113 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1754 Lys Lys Lys Lys Asn Asp Glu Lys His Ile Ala Lys His Phe Val Ala 1 5 10 Val Ser Thr Asn Lys Glu Ala Val Gln Gln Phe Gly Ile Asp Glu His 25 Asn Met Phe Gly Phe Trp Asp Phe Val Gly Gly Arg Tyr Ser Leu Trp 40 Ser Ala Ile Gly Leu Ser Ile Met Ile Tyr Leu Gly Lys Lys Asn Phe 55 Asn Ala Leu Leu Lys Gly Ala Tyr Leu Met Asp Glu His Phe Arg Asn 70 75 Ala Pro Phe Glu Ser Asn Leu Pro Val Leu Met Gly Leu Ile Gly Val 90 Trp Tyr Ile Asn Phe Phe Gln Ser Lys Gly His Leu Ile Ala Pro Tyr 100 105 110 Asp INFORMATION FOR SEQ ID NO:1755: SEQUENCE CHARACTERISTICS: LENGTH: 156 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature RAL LOCATION 1...156 PCT/U 76 0912 2 IPLEA.uo, I o C i396 1293 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1755 His Asn Lys Thr Arg Met Lys Arg Ala Lys Arg Arg Lys Phe Ile Thr 1 5 10 Lys Phe Ser Arg Tyr Tyr Thr Pro Ser Val Leu Phe Ile Ala Leu Met 25 Ile Ala Val Leu Pro Pro Leu Phe Ser Met Gly Ser Phe Asp Glu Trp 40 Ile Tyr Arg Gly Leu Val Ala Leu Met Val Ser Cys Pro Cys Ala Leu 55 Val Ile Ser Val Pro Leu Gly Tyr Phe Gly Gly Val Gly Ala Ala Ser 70 75 Arg Lys Gly Ile Leu Met Lys Gly Val His Val Leu Glu Val Leu Thr 90 Gin Thr Lys Ser Ile Ala Phe Asp Lys Thr Gly Thr Leu Thr Lys Gly 100 105 110 Val Phe Lys Val Val Asp Ile Val Pro Gln Asn Gly His Ser Lys Glu 115 120 125 Glu Val Cys Ile Thr Leu Leu Ala Arg Ser Phe Tyr Pro Arg Thr Arg 130 135 140 Ser Leu Tyr Pro Phe Lys Lys His Ala Lys Lys Cys 145 150 155 INFORMATION FOR SEQ ID NO:1756: SEQUENCE CHARACTERISTICS: LENGTH: 99 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION 1...99 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1756 Arg Ser Thr Leu Ala Ser Ala Asp Val Gly Ile Gly Met Gly Lys Gly 1 5 10 Ser Glu Leu Ser Lys Gin Ser Ala Asp Ile Val Ile Thr Asn Asp Ser 25 Leu Ser Ser Leu Val Lys Val Leu Ala Ile Ala Lys Lys Thr Lys Ser 40 Ile Ile Trp Gln Asn Ile Leu Phe Ala Leu Gly Ile Lys Ala Val Phe 55 Ile Val Leu Gly Leu Met Gly Val Ala Ser Leu Trp Glu Ala Val Phe 70 75 Gly Asp Val Gly Val Thr Leu Leu Asp Leu Ala Asn Ser Met Arg Thr 90 Met Arg Ala INFORMATION FOR SEQ ID NO:1757: SEQUENCE CHARACTERISTICS: LENGTH: 361 amino acids TYPE: amino acid PO/VS 9 6/ 0912 IPEAIUS o DEC 1996 1.294 TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscjfeature LOCATION .361 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1757 His Gin Son Ph. Lys Arg Ala Phe Glu Pro Arg Ang Lys Gly 2 1 Ph.
Ala Ala Tyr Thn Leu Arg Ala Lys 145 As n Tyr Asp Leu Tyr 225 Phe Tyr His Ser His 305 Val Ala A.rg Gln Gly Lou Phe Leu Phe Cys 130 Gin Gly Glu Asp Ala 210 Gin Thr G ly Phe Ala 290 Arg Ile Tyr Ile Lys Ala Ile Thr Lys Gly 115 Asp Leu Met Lou Lou 195 Lys Asp His Phe Lys 275 Glu His Cys Gin Met Ile Gly Gly Asn Asn 100 Leu Phe Lys Met Tyr 180 Lou Glu Thr His Arg 260 Gly Ile Ile Lys Ile 340 31y Ser Ala Lays Gin Leu Sen Ile Asp 165 Gin Cys Thr Asn Asn 245 Gly Ala Lou Lys Giu 325 Gin Phe Ala Gly Cys 70 Ala Ala Phe Val1 Ser 150 Lou Asn Lou Sen Ala 230 Lou Ala Lys Ala Thr 310 Tyr Ser 31u :ys 55 G1y Ser Lou Lou Lou 135 As n Ser Ala Ser Giu 215 Leu Cys Asp Ile Cys 295 Lou Pro Pro Lys His 40 Thr Val1 Lys Ile Arg 120 Asp Phe Val1 Lou Lou 200 Arg Gin Val1 Ile Val 280 Ala Gin Thr Phe Ser 25 Ile C Lys IJ Pro Giu Pro 105 Gin Ser Arg Gin Lys 185 Lys Tyr Lou Val1 Ser 265 Lys Asn Ser Gin Lys 345 .0 ~le ;in Lhr ;er de t Pro Hiis Asp Ala Asp 170 Lys Ile His Giu G ly 250 As n Lou Ser Phe Lys 33( Lou Asp Gly Pro Leu Thn .u Asn 75 Gin Giu Lou Lou Met Asn Giu Val 140 SenIlie 155 Ser Giu Asp Asn Lou Gin Tyr Ile 220 Phe Lou 235 Asp Asp Ile Lou Giu Thr Lou Ile 300 Asn Lou Ser Thr Arg Cys Lou 125 Lys Ser Cys Lou Asp 205 Met Lys Asp Asn As n 285 Ser Lou2 Lou Ang Lou Ala Thr 110 Lou Thr Gin Tyr Val1 190 Asn Val Gin Gin Phe 270 Tyr His krg ksn Leu Tr Lou Phe Lys Lou Ile Lys 175 Asp Glu Asp Lou Ser 255 Ser Ang Asri Val Gly Lou Ala Leu Lys His Arg Cys Lys 160 Ala Ph.
Lys Giu Ser 240 Ile Lys Ser Gin Lys Gly Sor His Lys Ser 315 320 Glu Giu Son Lou Asp Val 335 Giu Gly Arg Glu Phe Arg Lys Tyr Arg Tyn 355 Phe Val Sen Phe Lys Trp 360 INFORMATION FOR SEQ ID NO:1758: 1295 SEQUENCE CHARACTERISTICS: LENGTH: 842 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...842 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1758 Phe Val Leu Asn Glu Glu Gln Asn Ser Leu Glu Glu Lys Gly Gly Glu 1 5 10 Asn Lys Asn Glu Lys Glu Thr Pro Leu Lys Gly Ile His Ser Lys Ile 25 Pro Ser Leu Lys Gin Ala Leu Glu Gin Thr Ile Ser Lys Ile Lys Ser 40 Ser Lys Glu Phe Phe Lys Gin Leu Leu His Asn Lys Lys Lys Leu Tyr 55 Ile Ala Leu Gly Ile Leu Leu Ser Leu Ile Ala Leu Ile Val Ala Leu 70 75 Ser Leu Leu Leu Gly His Lys Lys Glu Asn Lys Gln Thr Ser Leu Gin 90 Thr Asn Thr Ala Thr Thr Asn Asn Glu Thr Pro Asn Asp Thr Asn Asn 100 105 110 Ala Giu Ala Glu Gly Gin Ile Glu Asn Leu Asp Leu Pro Asp Leu Ile 115 120 125 Gly Lys Asp Ser Leu Lys Arg Asn Asp Glu Ser Gin Val Asp Ala Met 130 135 140 Met Gin Lys Ala Ser Leu Leu Tyr Glu Gin Gly Gin Lys Asp Glu Ala 145 150 155 160 Leu His Leu Phe Asp Lys Ile Ala Ser Phe Ser Gin Gly Ile Ala Ser 165 170 175 His Asn Leu Gly Val Ile Lys Phe Lys Glu Lys Asp Phe Asn Gly Ala 180 185 190 Leu Asp Leu Phe Asp Ser Ser Ile Ala Ser Lys Glu Asn Ala Ser Val 195 200 205 Ser Ala Ile Asp Ala Leu Val Thr Ala Tyr His Leu Gin Asp Ala Asp 210 215 220 Leu Tyr Tyr His Tyr Leu Lys Ile Val Arg Asp Thr Leu Tyr Lys Asp 225 230 235 240 Tyr Lys Lys Ser Phe Tyr Ser Tyr Ala Tyr Ala Leu Lys Ser Tyr Tyr 245 250 255 Ala Gly Glu Tyr Phe Glu Ala Leu Ser Pro Leu Met His Pro Asn Ser 260 265 270 Asn Ala Phe Leu Lys Pro Asn Ala Arg Leu Ala Ser Lys Leu Phe Leu 275 280 285 Met Phe Lys Asp Glu Thr Asn Ala Tyr Lys Gln Leu Gln Lys Ser Ala 290 295 300 Asn Ala Gin Asp Glu Leu Ala Leu Gly Leu Leu Gln Ala Arg Leu Gly 305 310 315 320 Thr Tyr Lys Gin Ala Leu Glu His Leu Gin His Tyr Leu Asn Tyr 325 330 335 Pro Lys Asp Leu Asn Ala Leu Met Ala Leu Glu Leu Val Ser Leu Lys 340 345 350 Met Gly Asp Thr Leu Lys Ala Ser Glu Ala Leu Lys Leu Ala Ser His 355 360 365 Thr Gin Glu Asp Thr Leu Leu Ala Asn Ser Phe Tyr Pro Ile Lys Pro 1296 30 56 370 375 380 Thr Ile Asn Pro Met Ph. Leu Asp Lys Giu Arg Ala Lys Giu Arg Phe 385 390 395 400 Trp Asn Thr Gin Tyr Phe Giu Gly Lys Arg Asp Ph Ile Tyr Arg Leu 405 410 415 Leu Phe Tyr Tyr Ala Pro Phe Lys Val Leu Asp Ser Lys Giu Thr Leu 420 425 430 Gly Val Ile Giu Glu Gly Leu Ph. Leu Leu Asp Ser Asp Thr Gin Lys 435 440 445 Asp Lou Giu Giy Ala Ser Lou Aia Ph. Lys Arg Gly Arg Leu Met Ala 450 455 460 Ile Ala Asp Lys Asn Ala Leu Lys Gly Leu Lys Glu Leu Giu Lys Lys 465 470 475 480 Arg Leu Lys Lys Ala Leu Ser Phe Phe Asp Leu Ser Leu Lys Asn Ser 485 490 495 Pro Asn Asn Ala Lou Leu His Tyr Asn Val Giy Leu Ile Tyr Ala Gin 500 505 510 Lou Giu Asn Tyr His Lys Ala Tyr Ph. His Ph. Leu Arg Ala Ph. His 515 520 525 Leu Asn Ser Ala Asp Tyr LoU Ser Ala Val Phe Aia Val Lou Ala Ser 530 535 540 His Ph. Thr His Glu Asp Thr Thr Giu Phe Lou Arg Giu Ile Thr Giu 545 550 555 560 Asn Phe Tyr Ser His Asp Phe Sor Sor Pro Thr Gin Lys Ala Leu Leu 565 570 575 Ser Ser Leu Ile Ala Tyr Lou Asn Tyr Arg Thr Asn Trp Asp Met Asp 580 585 590 Trp Leu Lys Asn Ala Pro Lys Lys Lou Pro Phe Tyr Tyr Ala Leu Glu 595 600 605 Ala Val Ph. Ala Lys Giu Ser Lys Asp Lys Lys Leu Met Val Gin Ser 610 615 620 Phe Gly Asn Leu Lys Lys Met Leu Pro Lys Asp Lou Ile Ser Asn Ile 625 630 635 640 Ph. Tyr Glu Ile Val Ser Tyr Tyr Asp Ala Ser Ile Arg His Thr Lou 645 650 655 Ser Ile Tyr Thr Leu Leu Asp Sor His Lys Ile Ser Trp Asp Gin Thr 660 665 670 Met Gin Gly Pro Ile Leu Gly Arg His Phe Tyr Thr Tyr Met Gly Ph.
675 680 685 Met Val Asn Asp Lou Asp His Gin Giu Arg Leu Leu Giu Gin Lys Ile 690 695 700 Ala Ser Leu Glu Arg Gly Giu Ala Pro Asn Asp Trp Leu Giu Asn Leu 705 710 715 720 Ala Leu Val Ser Leu Ph. Gin Giy Gin Tyr Glu Lys Ala Ser Ala Leu 725 730 735 Tyr Gin Asn Leu Ile Asp Gly Leu Lys Asp Asn Giu Ala Arg Leu Lys 740 745 750 Ile Lou Ala Giy Lou Thr Tyr Ile Ala Gin Asn Asn Tyr Asn Asn Ala 755 760 765 Ala Leu Trp Lou Giu Leu Gly Lys Lou Asp Asp Pro Asn Asn Giu Asn 770 775 780 Ile Arg Tyr Ala Lou Gly Lou Leu Tyr Gin Arg Lys Gly Asp Leu Lys 785 790 795 800 Ser Ala Lou Asn His Ph. Lou Ala Ile Lys Thr Ser Asp Ph. Ser Ser 805 810 815 Pro Tyr Ph. Asp Ph. Giu Ile Asp Thr Asn Lou Lou Lys Glu Arg Lou 820 825 830 Asn Gin Glu Glu Lys Gly Giu Ph. Leu Giu 835 840 INFORMATION FOR SEQ ID NO:i7S9: SEQUENCE CHARACTERISTICS: LENGTH: 356 amino acids Af'T 0~ PC 1 /US 9 0 /091?2 IPEAJ S 18 DEC1996 1297 TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...356 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1759 Lys 1 Thr Ile Gin Asp Ile Val Met Leu Tyr 145 Leu Glu Glu His Ser 225 Val Ser Ile Val Asp 305 Ile Leu Ala Val Thr Thr Thr Met Ile Arg Asn Asn Leu Thr Gin Lys Asn 130 Leu Gly Arg Phe Lys 210 Ile Asp Met Leu Asp 290 Gin Val Ser Lys Asn Ala Ala Gin Arg Leu Thr 115 Ala Ala Tyr Leu Gly 195 Val Leu Arg Gin Ile 275 Asn Ala Ala Glu Glu 355 Asp Leu Phe Glu Glu Ile 100 Gly Met His Ser Glu 180 Phe Gin Ile Arg Val 260 Thr Leu Leu Asn Gly 340 Ala 5 Arg Glu Glu Lys Ala Gly Glu Lys Arg Val 165 Ile Asp Lys Asp Met 245 Glu Glu Tyr Lys Asn 325 Arg Trp Pro Glu Thr 70 Ser Gly Gly Gly Asp 150 Gly Tyr Tyr Ser Glu 230 Glu Val Glu Lys Ala 310 Glu lie Thr Leu 55 Leu Lys Met Lys Glu 135 Ser Thr Ser Leu His 215 Ala Asn Asp Gly Ile 295 Asn Val Lys Lys Tyr 40 Lys Leu Arg Val Thr 120 Ser Lys Ile Lys Arg 200 Ala Arg Tyr Phe Ile 280 Glu Tyr Val Gin 25 Glu Lys Glu Ile Leu 105 Leu Val Glu Thr Asp 185 Asp Phe Thr Asn Thr 265 Lys Asn Leu Ile Glu 345 Ala Ile Ile 10 Tyr Lys Arg Val Leu 90 Asn Val Tyr Met Ala 170 Ile Asn Ala Pro Lys 250 Ile Lys Ala Phe Val 330 Gly Lys Met Val Leu 75 Lys Asp Ala Val Glu 155 Ser Val Met le Leu 235 Ala Asp Ala Ala Phe 315 Asp Leu Gly Lys Ser Arg Pro Met Gly Thr Val 140 Pro Val Tyr Lys Val 220 Ile Asp Glu Glu Leu 300 Ile Glu His Lys Lys Asp Ser Glu Arg Lys Leu 125 Thr Leu Arg Gly Tyr 205 Asp Ile Glu Lys Asn 285 Ser Asp Phe Gin Ile Val 1 Val Val Ser His Ile 110 Ala Val Tyr Asp Thr 190 Ser Glu Ser Val Asn 270 Leu His Lys Thr Ala 350 Ile Gly Leu Ala Glu Leu Glu Lys Phe Ala Phe Asp Ala Glu V. Ala Asn Asp Gin Phe 160 Asp Asp 175 Asn Asn Leu Glu Val Asp Gly Pro 240 Ala Lys 255 Arg Ala Phe Gly His Leu Asp Tyr 320 Gly Arg 335 Leu Glu Arg Phe Ser INFORMATION FOR SEQ ID NO:1760: r 1 PCT/US 9 6/0912 IPEA/US i 9OE396 1298 SEQUENCE CHARACTERISTICS: LENGTH: 365 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...365 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1760 Lys Leu Phe Leu Lys Pro Leu Lys Glu Thr Ser Leu 1 Val Ala Leu Ala Ala Met Glu Ser Asn 145 Asn Phe Leu Glu Lys 225 Tyr Leu Glu Ile Leu 305 Ala Arg Ile C)j Ala Tyr Arg Phe Ile Asn Glu Pro 130 Gly Glu Lys Asn Pro 210 Gly Ala Tyr Lys Glu 290 Glu Ser Lys Gin Lys Leu Phe Phe Met Tyr Val 115 Tyr Gly Val Asn Leu 195 Thr Asp Ser Asp Leu 275 Gly Lys Leu Glu Lys 355 Asn Pro Asp Gly Asn Pro 100 Val Leu Val Leu Pro 180 Asp Gly Phe Leu Gly 260 Arg Trp Arg Asn Ile 340 Thr 5 Ile Asn Lys Val Gly Leu Gin Gin Val Asn 165 Phe Leu Leu Asp Gin 245 Val Asn Trp Ala Ile 325 Ala Phe Lys Arg Ser Ala 70 Met Thr Ala Thr Phe 150 Asp Asn Asn Thr Ser 230 Ala His Ala Gin Leu 310 Ile Leu Phe Ile Ser Gin 55 Val Ser Leu Leu Gin 135 Gly Ala Leu Gin Leu 215 Gly Ile Val Leu Gin 295 Phe Ser Leu Tyr Val Leu 40 Pro Gly Lys Tyr Glu 12D Ser Val Leu Ile Lys 200 Ser Leu Ser Tyr Lys 280 Asn Ile Ser Phe Leu 360 10 Ala Leu 25 Ile Phe Phe Ile Val Met Glu Phe 90 Thr Thr 105 Lys Lys Pro Ile Asp Phe Lys Asn 170 Val Gly 185 Ala Asp Pro Ile Lys Ser Ala Ile 250 Ser Lys 265 Thr Ile Gly Asn Val Leu Leu Leu 330 Ser Met 345 Gly Asn Lys Phe Ser Val 75 Glu Ser Phe Lys Ser 155 Ile Lys Leu Met Tyr 235 Arg Thr Asn Phe Met 315 Met Gly Ile Ala Leu Ile Leu Lys Pro Pro Ser 140 Lys Asn Ser Phe Lys 220 Asp Arg Pro His Phe 300 Leu Val Ser Ile Ala Gly Ile Thr Ile Lys Tyr Asn 125 Ala Glu Glu Leu Phe 205 Arg Met Leu Met His 285 Ser Ile Val Ser Ser 365 Leu Leu Lys Ala Val Leu Gly 110 Leu His Arg Asn Arg 190 Thr Phe Ser Pro Lys 270 Gly Ala Ile Met Gin 350 Val Lys Arg Leu Ala Phe Ile Leu Ser His Asp 175 Tyr Glu Thr Tyr Leu 255 Asp Ile Met Leu Asn 335 Lys Gly Arg Tyr Leu Met Val Ser Phe Met Ile 160 Leu Ser Leu Ile Met 240 Gly Ile Gly Glu Met 320 Arg Glu r d PGT/US 96/O9la2 1299 IPENUS 16DEC -196 INFORMATION FOR SEQ ID NO:1761: SEQUENCE CHARACTERISTICS: LENGTH: 354 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .354 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:i761 Arg Ph.
Thr Val1 Asp Lys Ala Arg G lu Asn Glu Arg G ly Ph.
Asp 225 Ala Leu Leu Ala Ala 305 Asn Gly Val Ser Ile Lys Giu Glu Ser Gin Ala Val1 Leu Ile Ser Ile Ile 130 Met Leu Ile Val Gly 22.0 Gly Gin Giu Arg Glu 290 Ph.
Ile Asn Tyr Gin Thr Sen Ile Ile Tyr Lys Giu Ile Glu 100 Pro His 115 Ile Lys Ala Gly Gly Gly Asp Asn 180 Ser Gin 195 Ser Asp G2.u His Lys Lys Tyr Asp 260 Asp Glu 275 Asn Arg Asp His Leu Lys Ph. Arg Giu Ala Pro Thr Lys Ser 70 Leu His Lys Ser Thr Val Asp Ala Arg Gly 150 Leu Tyr 165 Gin Leu Phe Tyr Arg Thr Ile Glu 230 Val Glu 245 Asp Val Leu Leu Giu T~yr Gin Asn 310 Glu Asp Met Thr Asn 55 Giu Asp Giu Leu G ly 135 Val Ile Arg Leu Lys 215 Ph.
Asn Ala Asp Ala 295 Leu Phe Ph.
Glu 40 Leu Lys Lys Thr Asn 120 Leu Asp Ile Gly Ser 200 G ly Lys Leu Asn Ile 280 Leu Ser As n Ile Sen 25 Phe Ala Giu Gly Leu 105 Ala Lys Ile Gly Arg 185 Leu Val Leu His Giu 265 Asn As n Giu Ala Ph.
Gin Lys Leu Ile Lys Gin 90 His Lys Gly Lys Thr 170 Sen G iu Met Val Ph.
250 Gin Tyr Gin Glu Sen 330 Val1 Thr Leu Glu Lys Ph.
75 Pro Ala Gin Ala Leu 155 Giu Gly Asp Giu Thr 235 Asp Arg Asp Ile Glu 315 Val1 Ala Leu Sen Ile Arg Asp.
Val1 Leu His Val1 140 Thr Arg Arg Asn Lys 220 Ang Ser Thr Ile Ph.
300 Leu Glu Glu Ala oly Tyr Lys Ala Leu Leu Thr 125 Thr Asp His Gin Leu 205 Leu Ala Arg Ser Ser 285 Sen Leu Leu Lys Asp Met Asn Asp Val1 Val1 Lys 110 Lys Ile Giu Glu Gly 190 Leu Gly Val Lys Val 270 Ala Lys Gly Glu Leu Ile Thn Leu Leu Ile Gly Lys Glu Ala Val1 Sen 175 Asp Arg Pro Giu His 255 Lys Leu Leu Asp 335 Lys Thr Gly Glu Asn Leu Thr Glu Ala Thr Lys 160 Arg Pro Ile Lys Asn 240 Leu Asn Ile Lys Lys 320 Leu Ser 325 Giu Lys Ala Ser Pro Ile Glu PU iUS 96/09122 IPENUS 1 8 0E C1996 1300 340 345 350 Gly Leu INFORMATION FOR SEQ ID NO:1762: SEQUENCE CHARACTERISTICS: LENGTH: 107 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...107 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1762 Met Gin Lys Phe Phe Ser Arg Phe Arg Arg Trp Ala Leu Pro Phe Tyr 1 5 10 Phe Val Ser Ala Leu Ala Ala Ile Asp Ile Asp Glu Val Thr Glu Ala 25 Gin Ala Asn Ser Ile Lys Leu Ser Asp Gin Leu Val Ser Leu Ser Asp 40 Lys Leu Leu Glu Lys Ala Val Asp Arg Gly Arg Asn Thr Asp His Leu 55 Lys Asp Leu Asn Asp Leu His Glu Lys Ile Lys His Leu Arg Leu Ile 70 75 Leu Glu Pro Lys Pro Lys Gly Lys Glu Asp Ser Pro Asn Leu Gly Gly 90 Asn Lys Asp Met Lys Thr Val Glu Ile Gly Ser 100 105 INFORMATION FOR SEQ ID NO:1763: SEQUENCE CHARACTERISTICS: LENGTH: 275 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...275 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1763 Lys Asn Gin Ile Leu Gln Ile Pro Leu Leu Pro Pro Pro Pro Asn Asn 1 5 10 Glu Glu Leu Leu Lys Ser Ile Thr Asp Leu Lys Asp Arg Leu Lys Lys 25
RHE~T
POUS 96/09122 1301 PEA/US 18 8DEC 1996 Leu G1u Asp Leu Lys Leu Glu Asp Ph. Giu Pro Leu Arg Lys Leu Ser 40 His Phe Ile Val Ile Gly Asn Leu Phe Gly Lys Ser Ser Asn Asp Thr so 55 Gin Giu Asn Pro Lys Asp Ala Lou Lys Ser Thr Asn Phe His Giu Lys 70 75 His Thr Lys Pro Thr Giu Thr Thr Glu Leu Val Glu Giu Asn Lys Ala 90 Leu Thr Thr Giu Lys Giu Arg Leu Glu Arg Glu Asn Lys Asn Leu Thr 100 105 110 Ala Asp Lys Giu Asn Leu Thr Lys Glu Lys Thr Giu Leu Gin Lys Gin 115 120 125 Val Asn Glu Leu Lys Asri Ser Lys Gin Val Leu Glu Asn Glu Lys Ala 130 135 140 Asp Trp Leu Arg Glu Lys Glu Asn Lou Thr Lys Asp Arg Glu Asn Lou 145 150 155 160 Thr Lys Giu Lys Thr Giu Lou Thr Glu Lys Asn Lys Val Lou Thr Thr 165 170 175 Giu Lys Giu Arg Lou Ala Thr Glu Lys Giu Asn Lou Thr Lys Glu Lys 180 185 190 Thr Glu Ser Gin Lys Gin Val Asn Giu Lou Lys Asn Sor Lys Gin Val 195 200 205 Leu Giu Asn Giu Lys Ala Asp Lou Thr Asn Glu Asn Thr Lys Lou Lys 210 215 220 Thr Asp Lys Thr Asp Lou Thr Giu Lys Asn Gin Arg Leu Thr Thr Giu 225 230 235 240 Lys Thr Giu Lou Asn Asn Lys Ile Thr Gly Lou Ala.Thr Giu Lys Giu 245 250 255 Arg Leu Ala Ala Asp Lys Giu Asn Leu Thr Lys Glu Ser Arg Gin Arg 260 265 270 Lys Pro Asn 275 INFORMATION FOR SEQ ID NO:1764: SEQUENCE CHARACTERISTICS: LENGTH: 130 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Holicobactor pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .130 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1764 Ala Lou Ser Asn Cys Lou Ser Lou Ser Vai Arg Arg Trp Ph. Ser Pho 1 5 10 Ser Lys Lou Val His Arg Ph. Son Arg Asn Pro Cys Ala Ser Cys Asn 25 Arg Ala Arg Sen Cys Son Arg Leu Ser Arg Ser Lou Val Ser Ala Val 40 Thr Trp Trp Lou Sen Lou Sen Ph. Son Val Val Sen Ala Lou Ph. Sen 55 Leu Val Sen Ser Val Ile Leu Trp Val Sen Son Val Ph. Son Lou Ph.
70 75 V~er Leu Ser Ph. Ser Val Val Asn Ser Lou Ph. Ser Sen Val Sen Ang POT/U 9 6/ 0912.a IPENUS 18 Dr-'i996 1302 90 Ser Leu Ala Ala Asn Lys Arg Val Ph. Ser Leu Ala Lys Met Ser Phe 100 105 110 Ser Val Ph. Ser Ser Ala Ph. Ser Leu Val Ser Leu Leu Leu Phe Cys 115 120 125 His Asn 130 INFORMATION FOR SEQ ID NO:1765: SEQUENCE CHARACTERISTICS: LENGTH: 327 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc..fature LOCATION .327 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1765 Met Gly Thr Lou Ile Giu Lys Trp Ph. Gly Ph. Ser Gin Ile Arg Glu 1 5 10 Glu Leu Giu Ala Arg Ile Ser Glu Leu Giu Asp Glu Asn Thr Giu Leu 25 Lou Arg Giu Arg Giu Tyr Leu Ala Ala Glu Thr Son Glu Leu Lys Asp 40 Ala Asn Asp Gin Lou Arg Gin Lys Asn Asp Lys Lou Ph. Ile Thr Lys 55 Asp Lys Leu Thr Lys Giu Asn Thr Glu Leu Ph. Ala Giu Asn Glu Ser 70 75 Leu Sor Val Lys Ile Sor Gly Lou Glu His 5cr Asn Asp Gin Lou Trp 90 Gin Asn Asn Asn Lys Lou Thr Lys Glu Lys Ala Giu Lou Lys Thr Glu 100 105 110 Lys Asp Ile Lou Ala Lys Glu Asn Thr Arg Lou Lou Ala Ala Arg Asp 115 120 125 Arg Lou Thr Glu Glu Lys Arg Giu Lou Thr Thr Giu Lys Giu Arg Lou 130 135 140 Lys Arg Giu Asn Thr Giu Lou Thr His Lys Ile Thr Giu Lou Thr Lys 145 150 155 160 Glu Asn Lys Ala Lou Thr Thr Glu Asn Asp Lys Lou Asn His Gln Val 165 170 175 Thr Ala Lou Thr Asn Glu Arg Asp Son Lou Glu Gin Giu Arg Ala Arg 180 185 190 Lou Gin Asp Ala His Gly Ph. Lou Giu Lys Arg Cys Thr Asn Lou Glu 195 200 Lys Glu Asn Gln Arg Lou Thr Asp Lys Lou Lys Gin Lou Glu Sen Ala 210 215 220 Gin Lys Sen Lou Giu Asn Thr Asn Asn Gin Lou Ang Gin Ala Lou Glu 225 230 235 240 Asn Ser Asn Val Gin Lou Ala Gin Ala Lys Giu Lys Ile Ala Ile Glu 245 250 255 Lys Sen Glu Lou Glu Ang Glu Ile Ala Arg Lou Lys Son Lou Giu Gly 260 265 270 et Giu Ala Lys Sor Asp Lou Asp Lou His Asn Ang Ang Lou Ala Sen 275 280 285 POT/US 96/09122 SPEAUS i 8 0D199 1303 Ala Asn Glu Asp Leu Lys Arg Gin Asn Arg Lys Leu Glu Glu Glu Asn 290 295 300 Ile Ala Leu Lys Glu Arg Val Asp Gly Leu Asn Glu Gln Leu Ser Lys 305 310 315 320 Leu Gin Pro Gin Lys Pro Gin 325 INFORMATION FOR SEQ ID NO:1766: SEQUENCE CHARACTERISTICS: LENGTH: 93 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...93 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1766 Phe Lys Thr Ile Glu Arg Asn Asp Phe Lys Leu Asn Gly Leu Thr Lys 1 5 10 Ile Leu Gin Asn Lys Gly Tyr Lys Met Lys Thr Ile Lys Asn Gly Ile 25 Met Ile Gly Thr Leu Gly Ala Leu Leu Leu Ser Gly Cys Ser Ser Phe 40 Asp Ala Gin Arg Phe Ala Cys Leu Pro Lys Asp His Ser Ser Lys Asp 55 Ala Ser Thr Lys Lys Glu Ala Gin Tyr Ile Pro Lys Gly Phe Phe Asp 70 75 Pro Tyr Ser Ser Asn Leu Asn His Trp Asp Ser Thr Phe INFORMATION FOR SEQ ID N0:1767: SEQUENCE CHARACTERISTICS: LENGTH: 303 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...303 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1767 Ser Leu Asn Lys Gly Leu Ala Leu Phe Leu Val Lys Lys Ile Gly Val 10 al Ile Met Ile Leu Val Cys Phe Leu Ala Cys Ser Gin Glu Ser Phe POT/US 0 1~2 I PENIJ S 1 f9D EC 199 6 1304 Ile Arg Ph.
Phe Val Ser Gin Lys 145 Asp Ser Gin Ile Leu 225 Asp Ser Ser Phe Lys5 Pro so Leu Gin Ile Tyr Lys 130 Leu Ile Lys Ile Lys 210 Ser Asn Lys Gin Lys 290 Met Sor Gin Leu Leu Pro 115 Asn Ile Ile Aia Gin 195 Ciy Leu Vali :ys H{is 275 Ser Gin Tyr Asn Thr Leu 100 Asn Pro Giu Met Leu 180 Thr Lys Arg Tyr Gin 260 Lys Asp 25 Ala Gin Giu Lys Vali Met Lys Asn Asp Phe Ser 165 Lys Phe Ile Pro Thr 245 Me t Ala I'hr Lys Asp Vai 70 Asp Giu Pro Leu Ser 150 Lys Arg Thr Ser Phe 230 Ile Val1 Ile Glu Gin Giu Asn Asp Gly Ser Lys Ser Giu Pro Asn Tyr 135 Gin Giu Phe Phe Ser 215 Tyr Giu Leu Ser Leu 295 Asp Gin Asp Ser Asn 120 Lys Gin Gly Leu Asn 200 Tyr GiU Asn Lys Ile 280 Tyr Pro As n Asp 105 Asn Pro Asp Asp Lys 185 Asp Vali Ser Lys Lys 265 Asp Giu Val Phe Ser Giu Thr Ile Ile S er 90 Asn Giu Lys Phe Gin 170 Asp Thr Tyr Phe Aia 250 His Leu Giu 75 Phe Ser Asp Arg Tyr 155 Trp Gin Lys Thr Leu 235 Lou Ser Asp Giu Asn GiU Asn Lys 140 Pro Lou Asn Thr Thr 220 Leu Asli Thr Ph.
Arg Pro Lys Ala 125 Thr Leu Ile Asp Gin 205 Asn Glu Thr Asp~ Lys 285 Asn Giu Asn 110 Asn Lys Lys Giu Lys 190 Ile Asn Lys Met Lys 270 Lys Ala Asn Leu Asn Asn Asn Ile 175 Asp Aia Gly Lys Giu 255 Lou Glu Ph.
Ser Lou Ser Pro Gly 160 Gin Arg Gin Sor Ser 240
I
Asp Arg Ph. Lou Giu Cys Lou Lys Giu Ser 300 INFORMATION FOR SEQ ID NO:1768: SEQUENCE CHARACTERISTICS: LENGTH: 121 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Heiicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1..,.121 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:i768 Aia Trp Leu Lys Ser Arg Val Lou Met Lys Ang Lou Ala Vai Ala Lou 10 Ile Lou Val Leo Giy Val Val Trp Gly Lys Ser Lou Pro Lys Trp Ala 25 Lys Asp Cys Ser Lys Glu Met Arg Ile Giu Lys Thn Gin Thr Lys Asp 40 Glu Lys Ile Lou Val Cys Gly Met Ser Asp Ile Lou Leu Sen Asp Met so 55 PCT/US 96/09122 IPEA/US 18 DEC 1996 1305 Asp Tyr Ser Leu Ser Ser Ala Arg Gin Asn Ala Leu Glu Lys Val Met 70 75 Glu Ala Phe Lys Gly Asp Arg Ile Glu Ile Lys Ala Gly Glu Leu Lys 90 Ala Thr Phe Ile Asp Thr Asp Lys Val Tyr Val Leu Leu Arg Ile Thr 100 105 110 Lys Lys His Val Ala Leu Met Asn Glu 115 120 INFORMATION FOR SEQ ID NO:1769: SEQUENCE CHARACTERISTICS: LENGTH: 306 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...306 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1769 Gly Leu Ile Met Lys Lys Ile Ile Leu Ala Cys Leu Val Ala Phe Val 1 5 10 Gly Ala Asn Leu Ser Ala Glu Pro Lys Trp Tyr Ser Lys Ala Tyr Asn 25 Lys Thr Asn Ala Gln Lys Gly Tyr Leu Tyr Gly Ser Gly Ser Ala Thr 40 Ser Lys Glu Ala Ser Lys Gln Lys Ala Leu Ala Asp Leu Val Ala Ser 55 Ile Ser Val Val Val Asn Ser Gln Ile His Ile Gln Lys Ser Arg Val 70 75 Asp Asn Lys Leu Lys Ser Ser Asp Ser Gln Thr Ile Asn Leu Lys Thr 90 Asp Asp Leu Glu Leu Asn Asn Val Glu Ile Val Asn Gln Glu Ala Gin 100 105 110 Lys Gly Ile Tyr Tyr Thr Arg Val Arg Ile Asn Gln Asn Leu Phe Leu 115 120 125 Gin Gly Leu Arg Asp Lys Tyr Asn Ala Leu Tyr Gly Gln Phe Ser Thr 130 135 140 Leu Met Pro Lys Val Cys Lys Gly Val Phe Tyr Lys Gln Ser Lys Ser 145 150 155 160 Met Gly Asp Leu Leu Ala Lys Ala Ala Pro Met Glu Arg Ile Leu Lys 165 170 175 Ala Tyr Ser Val Pro Val Ser Ser Leu Glu Asn Tyr Glu Lys Ile Tyr 180 185 190 Tyr Gln Asn Ala Phe Lys Pro Lys Val Arg Ile Ala Phe Asp Asp Asn 195 200 205 Ser Asp Thr Glu Ile Lys Asn Ala Leu Met Ser Ala Tyr Ala Arg Val 210 215 220 Leu Thr Pro Ser Asp Glu Glu Lys Leu Tyr Gln Ile Lys Asn Glu Val 225 230 235 240 Phe Thr Asp Ser Ala Asn Gly Ile Thr Arg Ile Arg Val Ile Ile Ser 245 250 255 Ala Ser Asp Cys Gln Gly Thr Pro Val Leu Asn Arg Ser Leu Glu Val 260 265 270 sp Glu Lys Asn Lys Asn Phe Ala Ile Thr Arg Leu Gln Ser Leu Leu PCT/US 96/091_.
PENUS 1 8 DEC 1996 1306 275 280 285 Tyr Lys Glu Leu Lys Gly Tyr Ala Asn Lys Glu Gly Gin Gly Asn Thr 290 295 300 Gly Leu 305 INFORMATION FOR SEQ ID NO:1770: SEQUENCE CHARACTERISTICS: LENGTH: 339 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...339 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1770 Pro 1 Ile Gly Arg Ile Gin Lys Leu Lys Gly 145 Arg Ile Val Ile Leu 225 Gin Asn Phe Gin Leu Ile Gly Ile His Gin Leu Pro 130 Glu Ala Arg Asn Lys 210 Gly Lys Phe Lys Arg Val Gly Leu Ala Glu Lys Ala 115 Leu Ile Phe Gly Thr 195 Lys Phe Tyr Asp Gly 275 Val Gly Ala Asn Leu Asn Arg 100 Ser Val Leu Gly Asp 180 Leu Arg Asn Ala Phe 260 Leu Val 5 Leu Leu Thr Phe Ala Arg Ala Val Ser Ile 165 Phe Lys Tyr Asn Ile 245 Gly Ile Phe Arg Ile Gin Ser 70 Leu Val Leu Ala Leu 150 Gly Asp Asn Glu Thr 230 Glu Ala Lys Arg Val Ile Ala Gly Ala 40 Asn Thr 55 Val Leu Gin Arg Tyr Val Trp Leu 120 Thr Lys 135 Leu Leu Gly Gly Leu Tyr Pro Leu 200 Lys Glu 215 Tyr Ser Thr Phe Glu Phe Ala Tyr 280 Arg Val 25 Gly Thr Ala Leu Asn 105 Ile Pro Glu Thr Val 185 Thr Phe Leu Ser Asp 265 Arg Phe Leu Leu 10 Val Met Leu Gly Leu Gly Ile Leu Val 1 Asp Gin Phe 75 Phe Ser Gin 90 Leu Ala Val Pro Arg Ser Ser Ser Glu 140 Lys His His 155 Met Asn Ile 170 Glu Tyr Thr Gin Lys Val Asn Leu Leu 220 Ala Ile Ser 235 Asp Leu Ala 250 Phe Phe Glu Phe His Phe Ser Phe Glu 300 kla Val Sin Ala /al Asn Phe Ala 125 G1n Ile His Gly Asp 205 Trp Lys Phe Arg Arg 285 Ser Ile Ala Ala Gly Ser Ala Leu 110 Ile Tyr Pro Pro Thr 190 Phe Val Glu His Glu 270 Ser His Pro Met Ile Ser Val Thr Phe Glu Ile Ile Ala 175 Ala Glu Gly Asp Ser 255 Asp Leu Lys Gin Ala Phe Phe Phe Gin Leu Glu Leu Lys 160 Leu Trp Thr Leu Ala 240 Pro Ala His Ile Glu Met Asp Ile Asn Leu Tyr Lys PCTUS 95 0912 IPEAUS 18 DEC1996 1307 Asn Ala Leu Asp Val Phe Thr Thr Asp Ala Gin Ile Lys Glu Leu Asp 305 310 315 320 Leu Lys Val Leu Lys Asp Asp Lys Gly Phe Phe Pro Asn Tyr Gin Ala 325 330 335 Gly lie Val INFORMATION FOR SEQ ID NO:1771: SEQUENCE CHARACTERISTICS: LENGTH: 144 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...144 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1771 Gly Ala Lys Met Lys Lys Ile Gly Leu Ser Leu Cys Leu Val Leu Ser 1 5 10 Leu Gly Phe Leu Lys Ala His Glu Val Ser Ala Glu Glu Ile Ala Asp 25 Ile Phe Tyr Lys Leu Asn Ala Lys Glu Pro Lys Met Lys Ile Asn His 40 Thr Lys Gly Phe Cys Ala Lys Gly Val Phe Leu Pro Asn Pro Gin Ala 55 Arg Glu Asp Leu Glu Val Pro Leu Leu Asn Glu Lys Glu Ile Pro Ala 70 75 Ser Val Arg Tyr Ser Leu Gly Gly Val Ala Met Asp Asp Lys Ser Lys 90 Val Arg Gly Met Ala Leu Lys Leu Glu Asn Gin Asn Ala Ser Trp Thr 100 105 110 Met Val Met Leu Asn Thr Glu lie Asn Phe Ala Lys Asn Pro Glu Glu 115 120 125 Phe Ala Gin Phe Phe Glu Met Arg Leu Pro Lys Asn Gly Gin Gly Arg 130 135 140 INFORMATION FOR SEQ ID NO:1772: SEQUENCE CHARACTERISTICS: LENGTH: 528 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION 1...528 PCT/US 90/G912 1308 IPENUS I 81DE1A996 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1772 His Glu Phe Leu Ala Ile Asn Glu Leu Met Phe 1 Ser Lys Lys Ile Gin Ala Asp Thr Tyr 145 Glu Lys Pro Ser Asp 225 Arg Val Ile Trp Giu 305 Glu Gly Trp Ile Leu 385 Phe Gin Asn Thr Asn 465 Arg Phe Glu Pro Gly Leu Leu Gly 130 Lys Val Arg Ile Tyr 210 Lys Phe Gly Pro Lys 290 Ser Lys Val Lys Thr 370 Ala Ala Lys His Leu 450 Ile Leu Phe Asn Tyr Ile Ala Lys 115 Ile Ile Val Phe Leu 195 Pro Trp Ala Leu Thr 275 Lys Val Lou Asp Lou 355 Ala Tyr Ile Lys Lys 435 Ala Val Lys Pro Ser Ala Phe Ser 100 Asp Giu Ile Pro Gin 180 Val Giu Gin Asn Ser 260 Pro Thr Asp Ser Lou 340 Lys Ile Thr His Lys 420 Asp cys Asn 5 Gin Asn Leu Thr Val His Asp Lys His Pro 165 Lys Met Tyr Lys Ala 245 Phe Pro Gly Val Lys 325 Pro Arg Gly Gly Asn 405 Leu Gly Lys Arg Lys Phe Tyr Met 70 Arg Val Glu Giu Val 150 Arg Glu Asp Asn Lou 230 Leu Lou Phe His Tyr 310 Thr Asn Phe Gin Lou 390 Gin Gin Thr Thr Met 470 Glu Pro Asn 55 Gin Pro Lou Glu Tyr 135 Asn Ser Ala Ala Leu 215 Gin Tyr Giu Ile Gly 295 Ph.
Lou Glu Asn Gly 375 Ile Gin Ala Ala Gly 455 Lys Leu Lys 40 His Ser Lou Gly Asn 120 Asn Ala Asn His Glu 200 Asn Asp Pro Asn Glu' 280 Asn Tyr Arg Phe Gin 360 Ser Ala Pro Leu Tyr 440 Thr Glu Lou 25 Glu Asn Lou Asp Tyr' 105 Gin Lys Leu Asn Lys 185 Asn Asp Asp Pro Lou 265 Val Ser Lys Glu Val 345 Asp Phe Thr Lou Arg 425 His Ala Lys 10 Glu Thr Lou Tyr Lys 90 Val Tyr Phe Asn His 170 Lou Gly Phe Ile Gly 250 His Gly Asn Phe Val 330 Gly Trp Lou Gly Lys 410 Val Ser Gin Asp Lys Leu Ile Thr 75 Arg Gly Ser Leu Gin 155 Ser Phe Glu Val Tyr 235 Ser Ile Lys Lou Gly 315 Gly Ile Arg Ala Lys 395 Asp Gly Thr Val Met 475 Asp Ile Lou Lys Lys Tyr Val Gin Gin 140 Glu Gin Val Lou Gly 220 Asn Val Thr Arg Tyr 300 Leu Phe Val Val Thr 380 Lou Pro Met Arg Val 460 Giu Val Glu Asn Val Leu Tyr Ala Ile 125 Gly Leu Leu Asn Lou 205 Gly Pro Val Glu Lys 285 Lys Glu Gly Pro Gly 365 Pro Ala Leu Tyr Gly 445 Glu Tyr Phe Val Asn Val Ile Pro Ser 110 Val Lys Ala Ser Lys 190 Val Ile Lou Lys Asn 270 Phe Ala Ile Glu Asp 350 Asp Lou Thr Asn Glu 430 Ser Ile Phe Leu Ile Tyri Gly.
Gin Asn Lou Gly Val Thr Lou 175 Arg Ala Ser Lou Met 255 Thr Arg Ile Ser Lys 335 Asn Thr Gin Pro Ser 415 Val Lys Ala His Pro Gin Gin Phe Thr Asn Gin Lys Gly Leu 160 Asp Gly Gly Gin Asn 240 Gly Thr Asp Arg Ile 320 Thr Lou Lou Val His 400 Phe Cys Val Gin Arg 480 His Ala Trp le Thr Ala Phe Lou Pro Tyr Glu Lys Pro Lys Tyr 495 A I I -r WPENS 1 8iuJ 6 1309 Ala Ile Thr Ile Lou Val Giu His Gly Glu Gly Gly Ser Lys Leu Gly 500 505 510 Gly Leu Leu Val Lys Met Ser Asn Lys Leu Tyr Glu Leu Gly Tyr Leu 515 520 525 INFORMATION FOR SEQ ID NO:1773: SEQUENCE CHARACTERISTICS: LENGTH: 280 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES ORIGINAL SOURCE: ORGANISM,: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1. 280 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1773 Ile Asn Ph. Val Asn Lys Gly Val Phe Met Asn Ile Ile Lys Lys Val1 Thr Ala Arg Arg Ser 145 Ile Lou Ile Asp Gly 225 Ala Glu Lys Cys Val His His Val Gly s0 Asp Asp Asp Tyr Asn Tyr Lys Met 115 Phe Tyr 130 Val Ile Lou Leu Tyr Ala Lys Pro 195 Gly Ala 210 Ala Lou Sen Ang Ala Lou Gly Ala 275 Thr Lys Ala Lou Val Ph.
100 His Sor Ala His Thr 180 Lou Ile Phe Glu Gin 260 Ile Ala Glu An Lys Lou Gin Lou Gin Val Lys 165 Giu Glu Ile Sen Asp 245 Ser Ilie Ile Lys Pro Glu 70 Pro His Val1 Lys Pro iso Gin Ph.
Ala Thr Glu 230 Asn Glu Pro Val Lys Val1 55 Lys Asn Arg Gly Ile 135 Asn Gly Asp Ala Gly 215 Asp Ala Lys Ala Lou Glu 40 Pro Gly Lou Pro Lou 120 Thr Asp Lou Ile Lou 200 Asn Lys Gin Thr Phe 280 G ly 25 Asp His Ile Ala Tyr 105 Ala Asp Pro Ile Val 185 Lou Tyr Asp Asp Arg 265 Ph.
His Ala Lys Lou 90 Lou Asn Ile Ala Ala 170 Lys Pro Ala Ser Glu 250 Lys Ph.
Lys Gin Lou 75 An Asp Ile Lys Asn Lou Asn Lys Lou Pro 235 Ala Phe An Ile Ile Val Asp Arg His An 140 Gin Lys Pro Val Gin 220 Tyr Ile Ile Ph.
Lou Thr Lou Ile Gly Ph.
Val 125 Lou Gly Asp Tyr Lou 205 Ala Ala Lys Lou Lys Lou Arg Gin Val Ser Asn 110 Glu Lys Arg Pro Asn 190 Gly Lys Asn Ala Asp 270 Arg Asp Glu Son Ser Lou Lou Pro Lys Ala Ser 175 Ile Asp Lou Lou Leu Thr Ile Ala Lou Val Ph.
Asp Asp Lou Gly Lou 160 An Lys Val Thr Val 240 Ile Tyr )INFORMATION FOR SEQ ID NO:1774: 1310 IPEAUS 18 UU C199 SEQUENCE CHARACTERISTICS: LENGTH: 326 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobactor pylori (ix) FEATURE: NAME/KEY: misc..feature LOCATION .326 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1774 1Met Met Ilie Thr Ph.
Pro Ala Gly Leu Ala Ala Arg Leu 145 Ile Val1 Pro Arg Gly 225 Ser Leu Asn Gin Gin 305 Gin Val1 Val1 Thr so Ser Lou Lou Phe Val1 130 Giy Gly Aia Sen Pro 210 His Gin Ala Sen Leu 290 Ile Asn Ph.
Ala Val Lou Leu Ala Ala 11s Ala Ser Gin Thn Arg 195 Lou Ph.
Ph.
Asp Arg 275 Leu Ph.
Glu Sen Leu Gly Pro Phe Trp 100 His Pro Ser Ile Leu 180 Asn Lou Thr Ser Val 260 Lys Lou Lou Gly Lys Lou Lou Lou Lou Asn Ser Arg Leu Lou 165 Ile Ala Val Thr Pro 245 Val Ph.
Phe Trp Ile 325 Gin Ser Tyr Gin Arg Ser Ser Met Met 70 Phe Phe Ile Asn Ala iso Asp Met Gly Gly 230 Asp Gly Ile Val G ly 310 His Ala Asp Ile 55 Lou Ala Trp Ph.
Lys 135 Met Trp Lou Thr 110 215 Ser Ile Sen Ala Ph.
295 Ile Phe Ile 40 Thr Leu Leu Val1 Trp 120 Lys Ile Arg Lou Lou 200 Tyr Thr Ph.
Ph.
280 Lys Gly Ile 25 Ala Ala Ser Ph.
Lou 105 Ser Gin Lou Ser Met 185 Ala Lou Ile Thr Leu 265 Ala Aen Ile Ph.
Lys Tyr Ala Ile 90 Lou Ile Gin Gly Thr 170 Trp Ser Lou Glu Lou 250 Ph.
Met Lou Thr Ph.
Asn Ser Ala Lys 75 Ph.
Lou Thr Ala Leu 155 Ph.
Lys Val Val Pro 235 Met Gly Val Glu Son 315 Ala Thr Ph.
Trp ile Sen Sen Ala Lou 140 Pro Gly Lou Pro Ile 220 Ph.
Lou Arg Lou Trp 300 Lou Lou Thr GlU 4S Val GlU His Arg Ser 125 Gly Lou Val Lou Ile 205 Met I1.
Ph.
Lou Val 285 Vai Thr Mt.
Glu Met Val1 Arg Ile Met 110 Lou Lou Gly Ile Pro 190 Lou Val Ile Val Tyr 270 110 Ile Ile Arg is Ph.
Giu Ser Lys Lou Gly Val Lou Arg Gly 175 His Met Ile Gin Ph.
255 Ala Cys Ph.
Thr Val Vai Ser Lou Arg Ser Ile Ile Ala I1.
160 Gly Lou Lys Ser Ile 240 Gly Lys Pro Lou Lou 320 INFORMATION FOR SEQ ID NO:1775: PCT/US 96/091i IPENAUS 18 DEC1996 1311 SEQUENCE CHARACTERISTICS: LENGTH: 88 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...88 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1775 Lys Gly Ile Gin Lys Lys Gin Asn Leu Lys Glu Val Ala Leu Asp Ala 1 5 10 Phe Leu Pro Lys Ser Ile Asn Tyr Tyr His Phe Asn Gly Ser Leu Thr 25 Ala Pro Pro Cys Thr Glu Gly Val Ala Trp Phe Val Ile Glu Glu Pro 40 Leu Glu Val Ser Ala Lys Gin Leu Ala Glu Ile Lys Lys Arg Met Lys 55 Asn Ser Pro Asn Gin Arg Pro Val Gin Pro Asp Tyr Asn Thr Val Ile 70 75 Ile Lys Ser Ser Ala Glu Thr Arg INFORMATION FOR SEQ ID NO:1776: SEQUENCE CHARACTERISTICS: LENGTH: 150 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...150 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1776 Arg Ile Ile Lys Met Lys Lys Thr Phe Leu Ile Ala Leu Ala Leu Thr 1 5 10 Ala Ser Leu Ile Gly Ala Glu Asn Thr Lys Trp Asp Tyr Lys Asn Lys 25 Glu Asn Gly Pro His Arg Trp Asp Lys Leu His Lys Asp Phe Glu Val 40 Cys Lys Ser Gly Lys Ser Gin Ser Pro Ile Asn Ile Glu His Tyr Tyr 55 His Thr Gin Asp Lys Ala Asp Leu Gin Phe Lys Tyr Ala Ala Ser Lys 70 75 Pro Lys Ala Val Phe Phe Thr His His Thr Leu Lys Ala Ser Phe Glu 90 Pro Thr Asn His Ile Asn Tyr Arg Gly His Asp Tyr Val Leu Asp Asn PCT/A 9/0,912 IPEA/US 1 8 s 1312 100 105 Val His Phe His Ala Pro Met Glu Phe Leu Ile Asn 115 120 Pro Leu Ser Ala His Phe Val His Lys Asp Ala Lys 130 135 140 Val Leu Ala Ile Gly Phe 145 150 INFORMATION FOR SEQ ID NO:1777: SEQUENCE CHARACTERISTICS: LENGTH: 383 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1...383 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1777 110 Asn Lys Thr Arg 125 Gly Arg Leu Leu Met Pro Val 1 Leu Ser Lys Asp Gly Asp Ala Gin Thr 145 Gln Val Asn Asn Ala 225 Asn Val Ile Gln Asp Val Gln Arg Lys 130 Glu Glu Giu Thr His 210 Ile Gln Lys Met Ile Tyr Thr Ser Asp 115 Thr Gin Lys Gln Gln 195 Asn Glu Thr Ile A 5 Thr A Gly I Lys Leu Ala Lys 100 Arg Glu Glu Gln Glu 180 Lys Gin Ile Pro rg Val Leu la Lys Glu le Ala Phe Lys Ser Asp 55 Lys Thr His 70 Ile Thr Ala Lys Glu Val Ala Asn Lys Gln Glu Lys 135 Lys Gin Lys 150 Lys Thr Ser 165 Gln Gin Lys Asp Leu Val Phe Phe Ile 215 Glu Ala Glu 230 Ile Gln Pro 245 Gly Ser Lys Val Met Lys Trp 40 Trp Pro Met Ala Ser 120 Gin Thr Asn Thr Asn 200 Lys Cys Lys Lys Lys 25 Glu Ile Asn Leu Gln 105los Gly Lys Glu Ile Glu 185 Lys Lys Lys His Leu Ala Thr 10 Val Phe Lys I Ala Ile Lys Cys Gly Asn Ser Trp Phe 75 Met Asn Val 90 Ala Gln Lys Ile Glu Leu Thr G1u Gin 140 Gin Glu Lys 155 Glu Thr Asn 170 Gln Glu Lys Ala G1u Gin Leu Gly Ile 220 Thr Pro Lys 235 Leu Pro Asn 250 G1u Leu Ile 5 Met Asn Asp Val Asn cys G1u Glu 125 Glu Gin Asn Gln Asr 205 Lys Pr Se Al Met M 1 Val G Ser I Lys Ser Phe 1 Ala 110 Gin Lys Lys Gln Lys 190 Cys Ala o Thr r Lys a Tyr 270 et ly le !hr la Ala Glu Glu Gin Thr Ile 175 Thr Glnr Gly Ly G1 25 Le Lys Ile Lys Ala Ile Asp Asn Glu Lys Glu 160 SLys Asn G1u Ile s Thr 240 n Pro u Gln His Ser Gln Arg 260 Ala Glnr 26 Glu Leu 275 Glu Ser Leu Pro Tyr 280 Ser Gln Lys Ala Ile 285 Ala Lys Gln PCVPS ~/912 IPENIJS 1 8 DEC 1996 Val Asp 290 Arg Asp 305 Arg Ser Asp Pro Lys Ile Giu Lys 370 Tyr Asn Ala Ala 340 Ala Val1 Arg Ala Gin 325 His Asp Glu 1313 Tyr Leu 300 Lys Glu 315 Met Arg Ser Leu Lys Val Tyr Ser 380 INFORMATION FOR SEQ ID NO:1778: SEQUENCE CHARACTERISTICS: LENGTH: 332 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .332 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:i778 Asn Lys 1 Ph. Val Lys Asn His Ile Val Ala Thr Gin His Leu Ala Giu Ser Val 130 Gin Tyr 145 Gly Tyr Tyr Ie Val Leu Gly Ser 210 krg Lys 3iy Ala Ala Leu Giu Giu Ile 115 Ser Gly Giu Pro Ala 195 Tyr Lou Val Val Giy Giu Ile 100 Gly Lys His Ph.
Ala 180 Gly His Asn Ile Lys Giu Val s Lys Asp Thr Leu Thr 25 Val Leu Giu Arg Met 40 Giu Pro Lys Thr Lys 55 Lys Lou Ala Giu Giu 70 Thr Gly Gin Thr Leu Ile Val Asp Arg Leu 105 Gin Pro Gin Val Ala 120 Giu His Lys Tyr Ala 135 Val Ph. Ile Lys Leu 150 Val Asn Giu Ile Ser 165 Val Asp Lys Gly Ile 185 Tyr Pro Val Vai Asp 200 Asp Vai Asp Ser Sex 215 Ph. Lys Glu Ala Sex 230 Met Lys Vai Giu Val Tyr Aia Gly Giu Ile 10 Gly Cys Ala Asp Giu Asp Thr Lou Cys Giu Ph. Pro Giu 1 Ala Asp Gin Giu Asp Pro Ser Ph.
Ile Gly Gly Met 90 Lys Arg Giu Phe Ph. Arg Giu Thr 125 Lys Gin Ser Gly 140 Giu Pro Lys Glu 155 Gly Gly Vai Ile 170 Gin Glu Ala Met Ph. Lys Val Thr 205 Giu met Ala Phe 220 Arg Ala Ala Asn 235 LGiu Vai Pro Giu ~ro .Iys krg Gly Lys 110 Ile Gly Pro Pro Gin 190 Let~ Lys Met Val Giu Val Arg Ang Gly Lys 175 Asn Tyr Ile le ;iy 4et Lou Glu Ser Gly Ser 160 Giu Gly Asp Ala Gly 225 Leu Ser Met Giu Pro Ala Met Pro Val Lou 240 Giu Tyr Met HANS 18 8DL U1996 1314 Gly Met Val1 Arg 305 Asn Val Ilie 260 Asp Arg 275 met Phe Thr Tyr Ala Lys Asp Gly Met 310 Ile Leu Leu Ser 295 G1u Val1 Asn Lys 280 Thr Ph.
Giu Arg 265 Ile Asp Asp Lys 250 Arg Val1 Leu His Arg 330 Gly Gin Ala Phe 285 Ser Ala 300 Gly Glu dly Asri Pro Gin Pro Ser Leu Gly Ser 320 INFORMATION FOR SEQ ID NO:1779: SEQUENCE CHARACTERISTICS: LENGTH: 109 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1...109 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:i779 Sen Lys 1 Arg Asp Ilie Ala Lys Arg so Val Leu Ser Phe Lys Val Ang Lys Pro Ala Thr Ph.
Lys Ala Phe Ala Ser Ser Leu Val Sen Ser Lys Leu Glu Thr Gly Pro Asn Ala 100 Thr Lys Leu Lys Ser Val Arg Asn Phe Val 70 Cys Ser Lys Arg Pro Phe 40 Scr Asn 55 5cr Lys Ph. Cys Asn Arg Gly 5cr Ser Ile Ala Leu 105 Leu Phe Arg Ile Ile 90 Lys Glu Lys Val Cys 75 Lys Ala Thr Lys Lys Trp Tyr Val Val Tyr Asri Cys Ser Val Phe Leu Gly Arg Ala Ph.
Val Gly Leu Ser Trp Ala INFORMATION FOR SEQ ID NO:1780: SEQUENCE CHARACTERISTICS: LENGTH: 438 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni RA4/ (ix) FEATURE: NAME/KEY: misc-feature wu Tii PCT 1'S 9 5' 191 2 1315 IPEAUS 18DEC1996 LOCATION 1...438 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1780 Ile 1 Ser Tyr Lys Asn Asn Val His Leu Leu 145 Leu Lys Asn Thr Glu 225 Ala Ser Asn Thr Tyr 305 Val Phe Glu Leu Lys 385 Lys Asp Lys Arg Asn Ala Thr Met 5 Gin Lys Asp Ser Glu Gin Ser Leu Leu Asn Asn Asn Lys Val Val Leu Glu Glu Gln Ser 70 Leu Gin Gly Val Ser Gin Tyr Phe Ser Leu 100 Lys Asn Asp Leu Phe 115 Glu Asn Ala Gin Glu 130 Leu Leu Asn Ala Ala 150 Ile Thr Val Asn Lys 165 Met Gin Asn Ala Thr 180 Glu Ile Thr Gin Val 195 Asn Leu Leu Ala Leu 210 His Gly Arg Gly Phe 230 Glu Lys Thr Gin Lys 245 Met Gln Gin Glu Ala 260 Ser Ile Val Gly Ser 275 Val Lys Asn Asn Met 290 Asn Ile Asn Asn Arg 310 Val Phe Lys Asn Asn 325 Asp Ile Thr Ser His 340 Gly Ala Gly Lys Glu 355 Glu Ser His His Ala 370 Ala Val Gin Glu Asp 390 Val His Leu Met Glu 405 Lys Met Phe Tyr Glu 420 Ile Gin Lys Gly G1u 435 Phe Gly Ile Ala Leu Cys 40 Phe Lys 55 Val His Tyr Ser Ala Lys Lys Thr 120 Ser Met 135 Lys Asn Thr Gly Ser Leu Ile Ser 200 Asn Ala 215 Ala Val Ala Thr Asn Asp Ile Lys 280 Ile Val, 295 Val Phe Leu Tyr Lys Ser Asn Phe 360 Ser Val 375 His Val Asp Ser Lys Gin Asn Lys 10 Glu Leu 25 Leu His Ser Gly Phe Lys Leu Lys 90 Lys Thr 105 Phe Cys 31n Tyr Gl1y Glu 31n Asp 170 Ala Asp L85 Leu Ile Ala Ile Val Ala Lys G1u 250 Ile Gin 265 ly Asp Ala Gin :ys Gly Gly Met 330 Cys Arg 345 Ala Asn Gin Leu Gin Lys Lys Glu Glu Gly Phe Asn Leu Ala Glu Asn Ala 75 Ser Gln Asn Gly Gly Val Thr Ser Leu 125 Phe His Gin 140 Glu His Ser 155 Ile Glu Ser Ser Le4 Asn Asp Asp Ile 205 Glu Ala Ala 220 Asp Glu Val 235 Ile Ala Val Thr Asn Thr Val Glu Glu 285 Ala Ala Lys 300 Leu Ala Lys 315 Val Phe Gly Leu Gly Lys Thr Ser Gly 365 Glu Ala Asn 380 Ser Lys Tyr 395 His Val Lys Leu Val Val Ser Glu Ile Gly 110 Lys Glu Asn Leu Gin 190 Ala Arg Arg Val His 270 Leu Tyr Leu Leu Trp 350 Tyr Asp Leu Glu Gin Asn Gly Leu Ser Asp Glu Glu Thr Glu Tyr 175 Arg Glu Ala Lys Val 255 Asp Lys Thr Asp Asn 335 Tyr Arg Leu Glu Asn 415 Ile Leu Ile Asn Val Gly Tyr Gly Gly Gly 160 Glu Ser Gin Gly Leu 240 Lys Ile Ser Ile His 320 Ser Tyr Ala Val His 400 Ile His Thr Ala Asp 425 Glu Leu Asn Lys Ile Ile Glu 430 (2) 17 2 INFORMATION FOR SEQ ID NO:1781: SEQUENCE CHARACTERISTICS: PUi/US 9 6 /0 PEA/US 18DEC1996 1316 LENGTH: 344 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...344 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1781 Glu Trp Leu Met Leu Lys Lys 1 Leu Thr Ala Asp Phe Gly Lys Val Lys 145 Glu Tyr Lys Pro Ala 225 Asn Thr Gin Leu Phe 305 Thr Asp lie Thr Ser Lys Val Gly Ser Lys 130 Glu lie Gly Leu Ser 210 Asn Glu Ser Leu Thr 290 Gly Asn Ser Ile Asp Gin Glu Glu Ile Gly 115 Asn Ala Leu Val Thr 195 Phe Asp Leu Thr Asp 275 Ile His Ala Tyr Val Lys Ile Phe Ser Asn 100 Arg Met Ile Glu Lys 180 Leu Tyr Ile Lys Gin 260 Gin Asp Gin Ser Arg 340 5 Gly Asp Leu Arg Leu Leu Tyr Val Ile Arg 165 Thr Lys Asp Leu Ser 245 Asn Leu Leu Lys Asn 325 Asn Leu Ile Asp Phe 70 Leu Asp Thr Leu Ser 150 Tyr Ala Glu Pro Arg 230 Ala Ile Asp Asp Ile 310 Asp Leu Ala Arg 55 Tyr Ala Ala Glu Thr 135 Ile Leu Ser Ile Thr 215 Arg Leu Ala Gly Tyr 295 Leu Lys Ile Phe Tyr Gly 10 Ala Val Leu Val 25 Lys Ile Lys Asp 40 Lys Gly Arg Leu Ala Arg Phe Gu 75 Val Glu Asp Thr 90 Val Met Arg Ala 105 Gly Gly Ser Thr 120 Arg Glu Lys Thr Arg Ile Glu Lys 155 Asn Gin Thr Phe 170 Leu Gly Tyr Phe 185 Thr Met Leu Val 200 Lys Asn Leu Glu Leu Tyr Ser Leu 235 Asn Glu Val Pro 250 Pro Tyr Val Val 265 Leu Lys Thr Gin 280 Gin Arg Leu Ala Glu Lys Ile Ala 315 Asp Glu Asp Asn 330 Phe Ile Ala Gin Tyr Arg Ile Ala Glu Ile Leu Phe Met Ile Leu Thr 125 Leu Thr 140 Val Leu Phe Gly Lys Lys Ala Leu 205 Phe Ser 220 Gly Trp Ile Val Asp Glu Gly Tyr 285 Leu Glu 300 Lys Glu Val Val Pro Asn Pro Phe Lys 110 Gin Arg Ser His Pro 190 Pro Leu Ile Tyr Val 270 Thr Ser Lys Leu Trp Ser Ile Pro Glu Asn Gin Lys Lys Gly 175 Leu Arg Ser Ser Asn 255 Leu Ile Leu Prc Phe Val Val Tyr Arg His Ala Leu Leu G1u 160 Tyr Asp Ala Arg Ser 240 Gin Lys Lys Arg Lys 320 Leu Asn Ala Gln His 335 Glu His Arg Lu A T 0 Y2 ^u INFORMATION FOR SEQ ID NO:1782: PCTIUS 9S"f1 IPEA/US 18 8DEC 1996 1317 SEQUENCE CHARACTERISTICS: LENGTH: 593 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .593 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:i782 Ile Ile Thr Ile Phe Leu Ile Lys Thr Asn 145 Ile Ile Ala Sor Asp 225 Giu Aen Ile Gly Gin 305 As n Lys Ph.
Arg Lou Val1 Lys Giu Phe Ile Leu Ilie 130 Tyr Ser Met Lys Met 210 Asn Thr Lou Ala Val 290 Glin Lys Pro Glu Thr Pro Met Asp Thr Ile Leu Lou Lou Tyr Lou Ala Thr 115 Lys Val1 Lou Ile Lys 195 Gin Lou Lys Ile Leu 275 Gly Lou Tyr Giu Asn 355 Tyr Ph.
Ile Ser Thr Giu 100 Gin Lou Sor Ph.
Pho 180 His Aen Lou Glu Ph.
260 Ph.
Ala Gin Ph.
Thr 340 Ile Lys Val Asp Lou His Gin Val1 Asn Asn Gly 165 Ala Ser Tyr Ph.
Lou 245 Thr Ph.
Ile Asp Giu 325 Gin Ser Son Gl Ile Leu 70 Val1 Phe Lys Thr Lou 150 Ile Thr Ala Lou Asn 230 Tyr Ile Lou Ala Lou 310 Asn Ile Phe Sen Ile Val 55 Lou Ph.
Ser Asn Ile 135 Ph.
Lou Val Ser Tyr 215 Ph.
Lou Tyr Met Gly 295 Sen Tyr Lys Ser Pro Lou 40 Val1 Pro Ser Ile Lou 120 His Ph.
Ph.
Pro Ile 200 Sen Met Asn Aia Val 280 Tyr Ph.
Ph.
Lou Tyr 360 Ser Lys Lye 25 Pro Asn Thr Gly Asn 105 Aen Aen Aen Sen Cys 185 Asp Gly Lou Asn Asp 265 Ph.
Ile Tyr Cys Giu 345 *Pro *Asn Cys Ser Leu Lou Ile 90 Ile Ph.
Gly Lou Ile 170 Ile Lys Lou Asn Ph.
250 Val Ile Gin Gly Ile 330 Giu Asn Lys Ser Ile Pro Vai Lou Lou Lou 75 Lou Ile Phe Lou Gin 155 Sen Lou Lou Asp Ph.
235 Val Lou Ile Ala Lye 315 Leu Lye Sor Ile lal Asn Gin Leu Ser rhr Glu Hlis 140 Arg 110 Ile Gln Asn 220 His Lys Ile Lou Ph.
300 Trp Asp Ile Lye Tyr Ile Lou Ile Lye Trp4 Ser Gin Asn 125 Ile Ile Tyr Ser Asp 205 Gin His Val Thr Ser Son Ph.
Tyr His Leu 365 Ala Arg Ala Lou Hlis Gly Lou4 Lou 110 Lys Arg Ile Lou Asn 190 Gin Lye Lye Ala Thr 270 Lye Sen Ph.
Lye Ser 350 Ile Leu Thr Ser Val1 Thr Ala Gin Ala Asp Pro 31y Pro 175 His Lye Aen Ph.
Gin 255 Lou Lou Thn Ala Ile 335 Ile Phe Val Ph.
Ile Met His Lou Thr Asn His Lou Lou 160 Ph.
Ile GiU Lys I16 240 Lys Sen 110 Gin Ile 320 Pro *Thr *Giu *Gly R4' Asn Phe Asn Lou Sen Lou His RCTA'J S 9 9-12<hPENUS 18 UtG igSS6 1318 370 Lys Asn 385 Tyr Thr Gin Asp Gin Asp Met Gin 450 Leu Lys 465 Asn Thr Gin Lys Cys Ile Lys Glu 530 Lou Ile 545 Ile Val Leu Met Tyr Ala Ser Gly Lys Pro Lou Phe 435 Asn Ser Leu Gin Val1 Ph.
Ile Lou Lys Asn Giu 420 Ser Asn Phe Ph.
Arg 500 Leu Lou Thr Asp Lys 580 Ser 405 Lou Lou Ile Asp Gly 485 Ile Asp Asp His Gin 565 Gly Asn Tyr Thr Giu 470 Ala Ala Giu Ph.
Arg 550 Gly 375 Ser Gin Ser Ala Lys 455 Asn Gin Thr Pro Ile 53S Met Lys Ile Tyr Gly 440 Giu Ph.
Met Ser 520 Ph.
Asn Lou Ile His 425 Tyr Gin Gin Asn Arg 505 Ser Lys Sor Ile Thr Lou Ile Asn Ile 410 Gin Ser Lou Asn Gly 490 Ala Ala Lys Val Giu 570 Asn Gin Ile Lys Cys 475 Val Ph.
Ile Ser Lys 55S Gin Lou 380 Lou Asn Met Asp Gin 460 Lou Asp Leu Asp Gin 540 Gin Giy Ph.
Lou Lys Ser Asp 445 Lys Asn Ph.
Lys Pro 525 Sor Ala, Asn Lou Lou Tyr Ala 430 Asn Arg Asp Sor Pro 510 Ile Lys Asn Ph.
L~ys 590 Gly Ph.
400 Pro Lou 415 Ile Ph.
Lou Ph.
Giu Ile Cys Asn 480 Lou Gly 495 Ser Asn Met Glu Met Ala Giu Ile 560 Giu Thr 575 Gin Gin Gin Gly Leu Phe Cys Giu 585 INFORMATION FOR SEQ ID NO:i7S3: Ci) SEQUENCE CHARACTERISTICS: LENGTH: 117 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .117 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:i7S3 Pro Ser Met Ile Val Thr Glu Thr Ser Thr Gly 5 Val Gly Gly Ile Asp Tyr Lys Lys Ser Ala Ph.
25 Ala Lys Arg Gin Ph. Gly Ser Ala Ile Lys Pro -40 Ala Ph. Asp Asn Gly Tyr Sen Thr Thr Ser Lys s0 55 Ang Asn Ph. Giu Asn Gly Asn Tyn Ser Lys Asn 70 Ala Trp His Pro Sor Asn Tyr Thr Arg Lys Ph.
Leu Gin Giu Ala Lou Ser His Ser Lou Asn Lou 100 105 Thr 1 Lou Gin Ile Ala His Thr
COIRA)
R
.OA
Lys Asn Ph.
Ile Son Lou Ala Ile Arg Val Pro Val1 Gly Thr 110 -nriEET PCT/JUS 96/091 2 1319 Leu Ala Ile Ala Trp 115 INFORMATION FOR SEQ ID NO:1784: SEQUENCE CHARACTERISTICS: LENGTH: 148 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...148 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1784 Gin Gly Val Thr Thr Met Ala Phe Gin Val Asn Thr Asn Ile Asn Ala 1 5 10 Met Asn Ala His Val Gln Ser Ala Leu Thr Gin Asn, Ala Leu Lys Thr 25 30 1 Ser Leu Glu Arg Leu Ser Ser Gly Leu Arg Ile Asn Lys Ala Ala Asp 40 Asp Ala Ser Gly Met Thr Val Ala Asp Ser Leu Arg Ser Gin Ala Ser 55 Ser Leu Gly Gln Ala Ile Pro Asn Thr Asn Asp Gly Met Gly Ile Ile 70 75 Gin Val Ala Asp Lys Ala Met Asp Glu Gin Leu Lys Ile Leu Asp Thr 90 Val Lys Val Lys Ala Thr Gln Ala Ala Gln Asp Gly Gln Thr Thr Glu 100 105 110 Ser Arg Lys Ala Ile Gin Ser Asp Ile Val Arg Leu Ile Gin Gly Leu 115 120 125 Asp Asn Ile Gly Asn Thr Thr Thr Tyr Asn Gly Pro Ser Val Ile Val 130 135 140 Trp Ser Ile His 145 INFORMATION FOR SEQ ID NO:1785: SEQUENCE CHARACTERISTICS: LENGTH: 248 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...248 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1785
SHEET.
r'WlUS 9 6/ 0912 IPENUS 18DEC 1996 1320 Phe Lys 1 Ala Leu Ty'r Ser Lys Ile so Gly Asp Thr Leu Val Leu Ala Tyr Ser Leu 130 Asp Ile 145 Ala Val Arg Leu Asp Ser Ser Gly 210 Arg Thr 225 His Ala Val1 Leu Asn Gly Ile Giu Ala Ala 115 Ser Lys Thr Asn Val1 195 Gin Arg Cys Trp Ile 5 Ser Gly Gin Ser Gin Val Ser Leu Ser Val Giu Val 100 Ser Val Asn Leu Lys Asn Ser Giu 165 Leu Arg 180 Ser Asn Asp Giu Leu Asp Lou Leu 245 Ile Gin Ile Arg Thr 70 Lys Ile Ile Thr Asp iso Thr Ser Gly Thr Val1 230 Gin Ser Phe Lys Ile 55 Phe Val1 Asn Thr Leu 135 Ser Gly Ile Pro Lys 215 Arg Ser Val1 Thr Ala 40 Ala Lys Ser Lys Thr 120 Asn Asp Val1 Asp Ser 200 Gly Aia Tyr Thr As n 25 Ser Thr Gin Ser Asn 105 Ser Gly Gly Giu G iy 185 Ala Ser Ser Gin Arg 10 Lys Giu Ile Gly Gly Ala Val Asp 75 Ser Ala 90 Ser Asn Asp Val Ile His Arg Lou 155 Ala Tyr 170 Arg Gly Leu Thr Thr Asn Met Ser 235 Leu Phe Sor Leu Gly Gly Arg Ala Leu 140 Val Thr Ile Lys Tyr 220 Ile Ile Gin Thr Ile Val Thr Thr Val 125 Gly Thr Asp Giu Arg 205 Gly Arg Thr Val1 Thr Thr Asn Gly Gly 110 Gin Asn Ala Gin Ile 190 Trp Arg Tyr Gly Gly Ser Ala Asp Iie Val Ser Iie Ile Lys 175 Lys Sor Tyr Leu Gin Ala Asp Ser Val1 Gly Lys Gly Ala Asn 160 Gly Ile Lys Sdr Asn 240 INFORMATION FOR SEQ ID NO:1786: SEQUENCE CHARACTERISTICS- LENGTH: 130 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE- NAME/KEY: misc-feature LOCATION .130 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1786 Sen Pro Lou Trp Leu Lys Thr Arg Phe Pro Asn Ile Trp Lou Ala 1 5 10 Ile Lou Tyr Met Ala Ile Lou Lou Cys Ala Ile Ala His Ser Val 25 Lou Ile Lou. Arg Trp Tyr Val Sen Gly His Sen Pro Trp Sor Asn 40 Tyr Giu Ser Met Leu Tyr Ile Ala Trp Ala Sen Val Ile Ala Gly 55 Val Lou Arg Ser Lys Lou Ala Lou Sor Ala Ser Ser Ph. Lou Ala 70 75 Lys Gly Ala Ph.
Gly so POTUS 96/O91 IPENIUS 18 8utu 1321 Ile Ala Leu Phe Val Ala His Leu Gly Phe Met Asp Pro Gin Ile Gly 90 Pro Leu Val Pro Val Leu Lys Ser Tyr Trp, Leu Asn Ile His Vai Ser 100 105 -110 Val Ile Thr Ala Ser Tyr Giy Phe Leu Gly Leu Cys Phe Val Leu Gly 115 120 125 Ile Leu 130 INFORMATION FOR SEQ ID NO:1787: SEQUENCE CHARACTERISTICS: LENGTH: 370 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1. 370 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1787 Lys Arg Leu Glu Met Gly Leu Ser Val Gly Ile Val Gly Leu Pro Asn 1 5 10 Val Gly Lys 5cr Sen Thn Phe Asn Ala Leu Thr Lys Thr Gin Asn Ala 25 Gin Ser Ala Asn Tyn Pro Phe Cys Thr Ile Glu Pro Asn Lys Ala Ile 40 Val Asn Val Pro Asp Arg Arg Lou Asp Ala Leu Ala Gin Ile Val Lys 55 Pro Glu Arg Ile Leu His Sen Val Val Glu Ph. Val Asp Ile Ala Gly 70 75 Leu Ile Lys Gly Ala Sen Lys Gly Glu Gly Leu Gly Asn Gin Ph. Leu 90 Ala Asn Ile Lys Giu Cys Glu Val Ile Leu Gin Val Val Arg Cys Ph.
100 105 110 Glu Asp Asp Asn Ile Thr His Val Asn Asp Lys Ile Asp Pro Leu Asn 115 120 125 Asp Iie Glu Thr Ile Glu Leu Giu Lou Ile Lou Ala Asp Ile Ala Thr 130 135 140 Leu Asp Lys Arg Ile Asp Arg Lou Gin Lys Ala Leu Lye Sen Sen Lys 145 150 155 160 Asp Ala Lys Asn Leu Leu Glu Cys Ala Leu Sen Lou Lys Thr His Lou 165 170 175 Giu Glu Leu Lye Pro Ala Lys Thn Ph. Pro Leu Asn Thn Sen Glu Ala 180 185 190 Phe Leu Glu Leu Asp Lye Glu Lou Arg Phe Lou Ser His Lye Lye Met 195 200 205 Ile Tyr Val Ala Aen Val Gly Glu Glu Asp Leu Asn Ile Leu Aen Glu 210 215 220 His Ala Lys Lye Val Glu Asn His Ala Lye Val Gin Asn Ser Giu Phe 225 230 235 240 Val Ala Lou Cys Ala Lye Leu Glu Giu Glu Met Val Ser Met Sor Gly 245 250 255 -ARA4 Asp Giu Val Lye Glu Phe Lou Gin Ser Leu Gly Val Glu Glu Sen Gly ,q260 265 270 Lou Giu Lye Th Ile Arg Lou Sen Phe Lye Giu Lou Gly Lou Ile Asn POTUS 96/O91a HAWNU 18 8EC 1996 1322 275 280 285 Tyr Ph. Thr Ala Gly Val Lys Glu Val Arg Ser Trp Thr Ile Lys Lys 290 295 300 Gly Ser Ser Ala Pro Val Ala Ala Gly Val Ile His Lys Asp Ph. Glu 305 310 315 320 Lys Gly Ph. Ile Arg Ala Glu Thr Ile Ser Tyr Asp Asp Ph. Ile Ala 325 330 335 Tyr Lys Gly Glu Ala Gly Ala Lys Glu Lys Gly Ala Lou Arg Ile Glu 340 345 350 Gly Lys Asp Tyr Ile Val Gin Asp Gly Asp Val Lou His Ph. Arg Ph.
355 360 365 Asn Val 370 INFORMATION FOR SEQ ID N0:1788: Ci) SEQUENCE CHARACTERISTICS: LENGTH: 141 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyloni (ix) FEATURE: NAME/KEY: misc..feature LOCATION .141 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1788 Arg Asn Lys Thr Met Gin Ala Leu Lys Ser Leu Lou Glu Val Ile Thr 1 5 10 Lys Lou Gin Asn Leu Gly Gly Tyr Lou Met His Ile Ala Ile Ph. Ile 25 Ile Ph. Ile Trp Ile Gly Gly Leu Lys Ph. Val Pro Tyr Giu Ala Glu 40 Gly Ile Ala Pro Ph. Val Ala Asn Ser Pro Ph. Ph. Ser Ph. Met Tyr 55 Lys Ph. Giu Lys Pro Ala Tyr Lys Gin His Lys Met Sen Giu Ser Gin 70 75 Sen Met Gin Giu Glu Met Gin Asp Asn Pro Lys Ile Val Giu Asn Lys 90 Glu Tnp, His Lys Glu Asn Arg Thn Tyr Lou Val Ala Giu Gly Lou Gly .100 105 110 Ile Thr Ile Met Ile Lou Gly Ile Lou Val Lou Lou Gly Leu Trp Met 115 120 125 Pro Lou Met Gly Val Val Gly Gly Ph. Lou Sen Lou Glu 130 135 140 INFORMATION FOR SEQ ID NO:1789: Ci) SEQUENCE CHARACTERISTICS: CA) LENGTH: 77 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES .jj:fl T POT/U 96IO912 IPENIUS 18D0EC01996 1323 (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .77 (Xi) SEQUENCE DESCRIPTION: SEQ ID NO:1789 Arg 5cr Pro Pro Tyr Ser Phe Leu Phe Thr Thr Pro Glu Val Phe Val 1 S 10 Asn Gin His Phe Pro Trp Lou Ser Gly Ala Gly Arg Leu Val Val Lys 25 Asp Lou Ala Leu Phe Ala Gly Gly Lou Ph. Val Ala Gly Ph. Asp Ala 40 Lys Arg Tyr Leu Giu Gly Lys Gly Ph. Cys Lou Met Asp Arg Ser Ser 55 Val Gly Ile Lys Thr Lys Cys 5cr Ser Gly Cys Cys Sor 70 INFORMA~TION FOR SEQ ID NO:1790: SEQUENCE CHARACTERISTICS: LENGTH: 273 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc..feature LOCATION .273 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1790 Trp Cys Ph. Thr Asn Ile Gin Glu Ile Gly Asn Asp Ph. Lou Ile Pro 1 5 10 is Gin Ser Ph. Lys Lys Lys Asp Ph. Ser Asn Lou Ala Gin Gin Val Cys 25 His Arg His Glu Gly Ph. Gly Ala Asp Gly Leu Val Val Val Lou Pro 40 Ser Lys Asp Tyr Asp Tyr Glu Trp Asp Ph. Tyr Asn Sen Asp Gly Ser so 55 Lys Ala Gly Met Cys Gly Asn Ala Ser Arg Cys Val Gly Lou Ph. Ala 70 75 Tyr Gin His Ala Ile Ala Pro Lys Glu His Val Ph. Lou Ala Gly Lys 90 Ang Glu Ile Ser Ilo Ang Ile Giu Giu Pro Asn Ile Val Glu Sor Asn 100 105 110 Lou Gly Asn Tyr Gin Ile Lou Asp Thr Ile Pro Asn Lou Arg Cys Lys 115 120 125 Lys Phe Ph. Thr Asn Asn Sen Val Leu Glu Asn Ile Pro Met Ph. Tyr 130 135 140 Leu Ile Asn Thr Gly Val Pro His Leu Val Gly Ph. Val Lys Asn Lys 145 150 155 160 Leu Leu Asn Ser Lou Asri Thr Lou Glu Leu Ang Ala Lou Arg His 1S170 175 }Glu Phe Asn Ala Asn Ile Asn Ile Ala Ph. Ile Glu Asn Lys Glu Thr
C)
1 T~ OU POUS 96/O91a 1324 IPENUS 18 0 L U 1996 180 185 190 Ile Phe Leu Gin Thr Tyr Giu Arg Gly Val Giu Asp Ph. Thr Lou Ala 195 200 205 Cys Gly Thr Gly Met Ala Ala Val Phe Ile Ala Ala Arg Leu Phe His 210 215 220 Asn Thr Pro Lys Lys Ala Thr Leu Ile Pro Lys Ser Asn Giu Phe Leu 225 230 235 240 Glu Lou Ser Lou Lys Asn Asp Giy Ile Phe Tyr Lys Gly Val Ala Arg 245 250 255 Tyr Ile Giy Met Ser Val Leu Giy Met Gly Val Ph. Lys Asn Gly Cys 260 265 270 Phe INFORMATION FOR SEQ ID N0:1791: SEQUENCE CHARACTERISTICS: LENGTH: 359 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .359 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1791 Phe Lou Vai Gin Ph. Asn Gly Asp Asn Cys Met Lys Ala Gin Tyr Ph.
1 5 10 is Ph. Trp Ile Lou Ph. Lou Ile Gly Ph. Tyr Trp Met Lou Tyr Lou Tyr 25 Gin Asp Phe Lou Met Asp Ala Leu Ile Ala Gly Lou Lou Cys Val Gly 40 Lou Ph. Gin Val Lys Val Ph. Lou Asn Lys Arg Ph. Son Asn Val Ile 55 Son Sen Ph. Lou Cys Val Leu Val Lou Ala Son Val. Val Ile Val Pro 70 75 s0 Leu Tyr Ph* Ile Val. Tyr Lys Gly Ser Asn Val Ile Ph. Giu Ile Asn 90 Ph. Giu Lys Leu Ser Ala Leu Ile Lys Trp Lou Lys Gly Thr Ile Thr 100 105 110 Glu Asn Lou 3cr His Ph. Pro Ala Ile His Asp Gly Val Ser Lys Ph.
115 120 125 Lou Glu Ann Ph. Son Ala Ala Sen Ile Thr Gly Tyr Lou Lou Lys Val 130 135 140 Sor Ser Tyr Ile Gly Lys Tyr Sen Leu Lys Lou Val Thr Asp Ala Lou 145 150 155 160 Ph. I1e Lou Gly Lou Lou Ph. Ph. Ph. Ph. Tyr Tyr Gly Giu Lys Ph.
165 170 175 Tyr Arg Tyr Phe Lou Gly Val. Lou Pro Lou Giu Met Ann Gin Ser Lys 180 185 190 Lys Ile Ph. Giu Giu Val Ala Gly Ile Lou Arg Ile Val Lou Lou Thr 195 200 205 Sor Lou Ile Thr Val Ile Lou Glu Gly Val Ala Ph, Gly Thr Met Ile 210 215 220 I Ile Trp Ph. Gly His Asp Gly Trp Sor Leu Gly Ile Leu Tyr Gly Lou 225 230 235 240 'NT O PCT/US 96/09122 IPEAUS 18 DEC j996 Ala Ala Val Lys Leu 305 Ser Phe Glu Ser Ile Leu Pro 290 Lys Gin Phe Gin Leu Tyr Tyr 275 Ile Ile Phe Ile Lys 355 Val Glu 260 Ser Leu Asn Gly Ala 340 Thr Pro Ala Val 245 Leu Tyr His Ile Leu Leu Ile Val Phe 295 Glu Ile Leu 310 Phe Trp Gly 325 Leu Leu Arg Cys Glu Cys Gly Gly Ala 250 Gly His Val 265 Ile Gly Val 280 Ile Lys Lys Ile Phe Phe Ile Ile Val 330 Leu Tyr Glu 345 1325 Leu Ile Asn Glu Leu Ile Arg Ile 300 Ser Met 315 Gly Pro Asn Tyr Trp Ala Asp 285 Phe Ile Thr Phe Ile Ile 270 Ser Lys Ala Ile Ile 350 Pro Ile 255 Phe Ile Val Ile Thr Thr Gly Ile 320 Thr Ala 335 Gin Lys INFORMATION FOR SEQ ID NO:1792: SEQUENCE CHARACTERISTICS: LENGTH: 215 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...215 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1792 Arg Leu Asn Met Asn 1 Leu Ile Asn Phe Pro Gly Glu Tyr Ala 145 Glu Ala Tyr N o Tyr AIT O Leu Ala Asn Met Lys Trp Val Trp 130 Thr Met Lys Leu Glu Phe Lys Lys Thr Ser Gly Thr 115 Gly Gly Thr Thr Arg 195 Ser Leu Ile Pro Ile Ala Gly 100 Gly Gly Asn Gin Tyr 180 Tyr Gin Lys Val Ala Ser Gin Ser Gly Ala Glu 40 Thr Asn Lys Tyr Met Gin Asn Gly His Ile Tyr Asp 105 Tyr Gly Ala 120 Gly Gin Lys 135 Gin Gly Gin Asn Gin Glu His Thr Arg 185 Lys Asp Ile 200 Ile Ser 10 Glu Ser Gly Val His Ser Met Pro Tyr Ala 170 Asn Phe Ala Ala Phe Ile Asp 75 Leu Thr Thr Trp Asp 155 Leu Tyr Glu Asn Asp Lys Pro Thr Gly Asp Asn 125 Ser Met Ala Ile Arg 205 Ala Thr Gly Lys Gly Phe Glu Thr Leu Leu Leu Gly Ile Asn Val Gly Gly Leu Gin Ala 160 Thr Cys 175 Asn Ala Gly Arg FTPEAUS 1 EC6/0912.
iPEA/US 18 0EC 1996 1326 215 INFORMATION FOR SEQ ID NO:1793: SEQUENCE CHARACTERISTICS: LENGTH: 265 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...265 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1793 Ile 1 Leu Phe Ala Leu Leu Ile Phe Tyr Ala 145 Leu Leu Leu Leu Phe 225 Gly Leu Phe Tyr Pro Asn Gly Tyr Asn Asn Arg Met Gly Lys Leu Glu Gly Asn Ser Phe Tyr 130 Leu Phe Asn Phe Pro 210 Leu Val Leu His Asp Ile Thr Glu Thr Ala Phe Ala Leu Leu Glu 100 Ile Phe 115 Leu Phe Lys Thr Leu Gly Ala Thr 180 Ile Leu 195 Leu Met Gin Gin Asp Phe Thr His 260 5 Ala Leu Thr Leu Phe Ser Ser Asn Phe Leu 165 Arg Val Ser Gin Leu 245 Lys Leu Thr Met Leu 70 Ser Leu Leu Ala Ala 150 Val hIe Gly Ser Glu 230 Lys Leu Gly Val Leu 55 Val Lys Leu Phe Gin 135 Leu Leu Lys Val Ser 215 Leu Ile Glu Gin Leu 40 Thr Ala Arg Leu Trp 120 Ser Lys Met Lys Val 200 Leu Gin Leu Leu Val 25 Ala Leu Ile Gly Pro 105 Phe Ser Pro Lys Ala 185 Leou Ser Glu Leu Asp 265 Gly Val 1 Ser Ser Val Lys Val Val Thr Phe 170 Arg Glu Ile Asn Leu 250 Asn Cys Tyr Val 75 Leu Ile Ala Leu Lys 155 Leu Phe Leu Asn Lys 235 Ile Phe Thr Gly Ser Leu Ser Phe 140 Thr Phe Leu Ala Glu 220 Tyr Phe Val Ser Leu Ala Phe Leu Val 125 Ile Ile Val Leu Phe 205 Gly Tyr Leu Ile Ser Phe Ile Ser Pro 110 Arg Leu Gly Leu Gly 190 Asn Phe Leu Val Asn Set Ile Asn Pro Val Gly Thr Ala 160 Val Leu Leu Tyr Trp 240 Tyr Gly Val Ile Arg Tyr 255 INFORMATION FOR SEQ ID NO:1794: SEQUENCE CHARACTERISTICS:
RA>
TO j ,r 0 LENGTH: 198 amino acids TYPE: amino acid TOPOLOGY: linear PCT/US 96/09122 1327 IPE US 1 8DEC 1996 (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...198 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1794 His Met Lys Gly Leu Trp Leu Val Ile Ser Leu Val Phe Val Gly Phe 1 5 10 Leu Trp Ala Asn Glu Ser Tyr Val Phe Asn Asn Ser Lys Gly Arg Leu 25 Thr Glu Lys Ser Val Ala Phe Ile Glu Gly Val Ser Lys GIu Leu Tyr 40 Leu Lys Thr Gly Val Arg Phe Ala Ile Asp Met Thr Asp Phe Glu Lys 55 Asn Pro Ile Ala Leu Ala Asn Lys Lys Glu Arg Gin Ser Tyr Gin Glu 70 75 Gly Phe Leu Lys Gin Leu Lys Pro Pro Phe Val Val Phe Phe Phe Tyr 90 His Asp Ala Gin Lys Ile Glu Leu Val Ala Asn Pro Lys Asp Leu Leu 100 105 110 Asp Thr Asp Lys Ile Phe Phe Glu Lys Ile Ala Pro Leu Leu Pro Thr 115 120 125 Asn Ala Lys Glu Tyr Thr Pro Gin Arg Ile Ser Ala Met Leu Ile Asn 130 135 140 Gly Tyr Ser Val Ala Val Asp Ala Leu Ala Glu Lys Tyr His Val Asn 145 150 155 160 Ile Thr Gin Asn Phe Ser Ala Pro Lys Gly Val Thr Phe Val Lys Val 165 170 175 Val Ile Tyr Ile Leu Leu Leu Thr Leu Leu Gly Ala Phe Leu Gly Leu 180 185 190 Tyr Phe Phe Lys Lys Ser 195 INFORMATION FOR SEQ ID NO:1795: SEQUENCE CHARACTERISTICS: LENGTH: 197 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION 1...197 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1795 Glu Gly Lys Ser Met Lys Glu Lys Asn Phe Trp Pro Leu Gly Ile Met 1 5 10 Ser Val Leu Ile Phe Gly Leu Gly Ile Val Val Phe Leu Val Val Phe POT/US 96/09122 IPEANUS 1 8 J3S6 1328 25 Ala Leu Lys Asn Ser Pro Lys Asn Asp Leu Val Tyr Phe Lys Gly His 40 Asn Glu Val Asp Leu Asn Phe Asn Ala Met Leu Lys Thr Tyr Glu Asn 55 Phe Lys Ser Asn Tyr Arg Phe Ser Val Gly Leu Lys Pro Leu Thr Glu 70 75 Ser Pro Lys Thr Pro Ile Leu Pro Tyr Phe Ser Lys Gly Thr His Gly 90 Asp Lys Lys Ile Gin Glu Asn Leu Leu Asn Asn Ala Leu Ile Leu Glu 100 105 110 Lys Ser Asn Thr Leu Tyr Ala Gin Leu Gln Pro Leu Lys Pro Ala Leu 115 120 125 Asp Ser Pro Asn Ile Gin Val Tyr Leu Ala Phe Tyr Pro Ser Gln Ser 130 135 140 Gin Pro Arg Leu Leu Gly Thr Leu Asp Cys Lys Asn Ala Cys Glu Pro 145 150 155 160 Leu Lys Phe Asp Leu Leu Glu Gly Asp Lys Val Gly Arg Tyr Lys Ile 165 170 175 Leu Phe Lys Phe Val Phe Lys Asn Lys Glu Glu Leu Ile Leu Glu Gin 180 185 190 Leu Ala Phe Phe Lys 195 INFORMATION FOR SEQ ID NO:1796: SEQUENCE CHARACTERISTICS: LENGTH: 376 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc.feature LOCATION 1...376 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1796 Ala Asn Gin Phe Ala Leu Gin Phe Ser Phe Ser Asn Phe Lys His Gly 1 5 10 Asp Phe Thr Thr Arg Asp Phe Met Leu Tyr Ser Leu Lau Tyr Gly Tyr 25 Phe Asn Ile Asn Leu Phe Gin Tyr Leu Thr Phe Arg Ala Gly Leu Gly 40 Phe Phe Ile Ala Phe Phe Leu Thr Leu Phe Leu Met Pro Lys Phe Ile 55 Leu Trp Ala Lys Ala Lys Lys Ala Asn Gin Pro Ile Ser Ser Phe Val 70 75 Pro Ser His Gln Asn Lys Lys Asp Thr Pro Thr Met Gly Gly Ile Val 90 Phe Val Phe Ala Thr Ile Val Ala Ser Val Leu Cys Ala Ser Leu Ser 100 105 110 Asn Leu Tyr Val Leu Leu Gly Ile Ile Val Leu Val Gly Phe Ser Phe 115 120 125 Val Gly Phe Arg Asp Asp Tyr Thr Lys Ile Asn Gin Gin Asn Asn Ala S130 135 140 RAA(\ Gly Met Ser Ala Lys Met Lys Phe Gly Met Leu Phe Ile Leu Ser Leu 145 150 155 160 POUS 9 6/O0912a IPEN/US lI 1329 Ile Ala Val Leu Leu 225 Ser Val1 As n Ilie Leu 305 Ilie Met Lys Ala Val1 Pro Gly Thr 210 Leu Lys Ile Cys Gly 290 Leu Lou Ala Val1 Leu 370 Ser Phe Pho 195 Asp Ser Tyr Ser Asn 275 Giy Val1 Gin Pro Ile 355 Leu Val Leu 180 Trp Gly Leu Leu Leu 260 Pro Phe Leu Val1 Ile 340 Val1 Ser Lou 165 Lys Val1 Lou Ser Leu 245 Ala Ala Ile Met Gly 325 His Arg Lou Lou Asn Lou Asp Ile 230 Tyr Leu Ser Ala Giy 310 Ser His Phe Lys Ser Pro Vai Gly 215 Phe Pro Val1 Val1 295 Ser Tyr His Trp Val 375 Lou Lys Leu Phe 185 Ph. Lou 200 Lou Ala Val Tyr Lys Val Gly Ser 265 Ph. Met 280 Asn Ala Ile Ph.
Lys Thr Ph. Glu 345 Ile Ile 360 Cys Gly 170 Giu Ser Ser Val Ile 250 Leu Giy Ile Val1 Arg 330 Gin Lou Met Thr Val1 Ala 235 Asp Phe Asp Val1 Ile 315 Lys Lys Asp Pro Ser Pro 220 Gly Val Gly Ser Ser 300 Giu Lys Gly Thr Thr Asn 205 Ser Asn Giy Ph.
Giy 285 His Thr Arg Trp Ph.
Met 190 Ala Ile Ala Giu Leu 270 Ser Asn Leu Leu Ala 350 Lou 175 Lou Vali Phe Giu Leu 255 Trp Leu Glu Ser Phe 335 Giu Ser Met Leu Ser Asn Leu Val INFORMATION FOR SEQ ID NO:l797: SEQUENCE CHARACTERISTICS: LENGTH: 303 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .303 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1797 Arg Ph. Ile Lys Ile Ph. Gly Met Gly Lys Phe 5 10 Ile Lou Ala Thr Leu Gly Ser Sen Ile Gly Leu Phe Pro Tyr Met Val Gly His Asn Gly Gly Sen 40 Tyr Lou Ala Lou Thn Lou Sen Lou Gly Ile Ala 55 Met Lou Ile Gly Asn Lou Gly Lys Lys Asp Val.
70 75 Ile Lou Asp Pro Lys Ang Lys Lys Tyr Tyr Pro 90 Ile Leu Gly Gly Pro Lou Ile Lou Ser Ph. Tyr 100 105 Trp Val Lou Tyr Tyr Lou Ph. Val Val Thn Ph.
Ala 1 Phe Arg Leu Giu Gin Phe
A/R
UJx Ser, Gly Ala Met Val1 Phe Ala Asp Leu is Ile Val Lou As n Ser Val1 Pro Gly Tnp Leu Val Tyr Phe Lou Lys f~~3 ~E~T POUS 9 6/ 0912.a IpENJUS 18 D E 01996 1330 Asp Leu 145 Trp Val Ala Ph.
Gin 225 Ser Ile Ph.
Lou Leu 130 Ile Ph.
Leu Met G lu 210 Met Ala Val1 Thr Val1 290 115 Giu Trp Val Met Thr 195 Ile Phe Ph.
Lou Ph.
275 Ph.
Gin Pro Ser Pro 180 Leu Gln Ph.
Thr Pro 260 Val1 Ile Ala Val Arg 165 Leu Glu Lys Ser Pro 245 Gly Ph.
Ser Met 135 Gly Ile Ph.
Met Asp 215 Ser Lys Lou Tyr Pro 295 Ser Ala Gly 170 Ph.
Ala Val Val1 Leu 250 Lou Asp Ph.
Met Cys 155 Ile Ile Leu Val Gly 235 Leu Ile Val1 Ala Lou 140 Leu Glu Gly Arg Met 220 Thr Lys Ala Sor Lys 300 125 Gin Lou Lys Lou Ph.
205 Asp Ile Ser Gly Gln 285 Met INFORMATION FOR SEQ ID NO:1798: Ci) SEQUENCE CHARACTERISTICS: LENGTH: 426 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .426 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1798 1Arg Cys Val Lys Met Lys Ile Ser Lou Leu Gly His Gly Lys Thr Thr Leu Ph.
Cys Val His Ph.
Thr Gly Pro 145 Ala Asp Tyr Ser Leu Thr Thr Gly 130 Leu Lou Asp Pro Pro Met Pro Glu 115 Asn Trp Gly Lys Ser Gly Sen Thr 100 Met Ile Val1 Arg Ph.
Lys Ile Glu Met Leu Gly Leu Ph.
Pro Asp Sen 70 Tyr Ile Thn Thr Glu 150 Ph.
Ala Ph.
55 Ph.
Asp Ser Thr Pro 135 Thr Lys Ph.
40 Asn Thn Tyr Ile Lou 120 Leu Ser Lye 25 Ph.
Pro His Ile Ser 105 Leu Ile Sor Asn Lys Asn Pro Asp 90 Gly Giu Giu Ph.
His Asn Asp Ser Asp Sen Leu, Val 75 Ser Leu Thr Asn Asp Ph.
Lou Ph.
140 Ser Leu 155 Giu GiU Gin Met Ph.
Gly Lys 125 Glu His Val Gly Lou Lys Asp Lys 110 Ala Lys Tyr Lys Ph.
Glu Ala His Thr Val1 Arg Thr Ph* Leu.
Ile Lye Ser Thr Ser Ser Asn 160 11IAsc,6EO1 22 1331 Lys Ala Tyr Pro Lou Ile Tyr Leu Leu 165 Leu Val1 Phe Phe 225 Ala Leu Tyr His Asp 305 Phe Val1 Leu Giu Gin 385 Pro G iu His 180 Leu His Ser Phe Giu 260 Asn Giu Ala Gin Thr 340 Ilie Val1 Lys Ala Lys 420 Asn Pro Ile Giu 230 Gly Phe Leu Phe Asn 310 Ile Leu Ser Cys Val 390 Lou Phe Phe Lys Val1 215 Val1 Ala Leu Lys Arg 295 Ile His Ph.
Ser Gin 375 Lou Asp Val1 Glu Thr 200 Gin Leu Phe Lys Arg 280 Asp Asp Leu Glu Ala 360 Val1 Leu Gin Leu Asn 185 Ser Asn Giu Leu Ile 265 Leu Lys Ala Ile Glu 345 Ser Cys Gin Phe Lys 425 Ile Asn Val 170 Ty~r Leu Asn Leu Ala Ile Ser Gin Ala 220 Cys Lou Lys 235 Lou Asp Ala 250 Lys Asn Lou Asn Ala Phe Gin Gly Arg 300 Thr Lou Gin 315 Lou Giy Gly 330 Ph. Lys Asn Ile Ile Gin Lou Lys Loq 380 Asn Glu Val 395 Ser Sor Tyr 410 Asp Glu Ala Asp 175 Ala Lys Lou 190 Lou Pro Lou 205 Gin Lys Ile Ile Pro Ser Ala Lou Ala 255 Lys Trp Gin 270 Lys Ile Gly 285 Lou Trp Val Ala Lou Lys Asp Ile Lys 335 Tyr Lys Ile 350 Ala Lou Ala 365 Giu Lys Ala Ala.Lou Lou Lys Giu Arg 415 His Lys Lys Ph.
Asn 240 Lou Asp Sor Asp Thr 320 Gly Ser Lou Val Sor 400 Gly INFORMATION FOR SEQ ID NO:1799: SEQUENCE CHARACTERISTICS: LENGTH: 270 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE- protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-f.eature LOCATION .270 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1799 Asp Met Giy Asn His Phe Sor Lys Lou Gly Pho Val Lou Ala Ala Lou 1 S 10 Gly Son Ala Ile Gly Lou Gly His Ile Trp Arg Phe Pro Tyr Met Thr 25 Gly Val Sen Gly Gly Gly Ala Phe Val Lou Lou Ph. Lou Ph. Lou Sen 40 Lou Sen Val Gly Ala Ala Met Phe Ile Ala Glu Met Lou Lou Gly Gin so 55 \Ser Thr Gin Lys Asn Val Thr Giu Ala Phe Lys Glu Lou Asp Ile Asn POUS 96/0912Z IPENUS 18 DEC 1996 1332 70 75 so Pro Lys Lys Arg Trp Lys Tyr Ala Gly Ile Met Leu Ile Ser Gly Pro 90 Leu Ile Leu Thr Ph. Tyr Gly Thr Ile Leu Gly Trp Val Leu Tyr Tyr 100 105 110 Leu Val Ser Ile Ser Phe Asn Leu Pro Ser Ser Ile Gin Giu Ser Giu 115 120 125 Gin Ile Phe Thr Gin Thr Leu Gin Ser Ile Gly Leu Gin er Ile Giy 130 135 140 Leu Phe Ser Vai Leu Phe Ile Thr Giy Trp Ile Vai Ser Arg Giy Ile 145 iso iss 160 Lys Giu Giy Ile Giu Lys Leu Asn Leu Vai Leu Met Pro Leu Leu Ph.
165 170 175 Aia Thr Ph. Ph. Giy Lou Leu Ph. Tyr Ala Met Ser Met Asp Ser Ph.
180 185 190 Ser Lys Ala Ph. His Ph. Met Ph. Asp Ph. Lys Pro Lys Asp Leu Thr 195 200 205 Ser Gin Val Ph. Thr Tyr Ser Leu Gly Gin Val Ph. Ph. Ser Leu S-er 210 215 220 Ile Gly Leu Gly Ile Asn Ile Thr Tyr Ala Ala Val Thr Asp Lys Thr 225 230 235 240 Gin Asn Leu Leu Lys Ser Thr Ile Trp Val Val Lou Ser Gly Ile Leu 245 250 255 Ile Ser Leu Val Gly Arg Ala Tyr Asp Ph. His Ph. Cys Vai 260 265 270 INFORMATION FOR SEQ ID NO:1S00: SEQUENCE CHARACTERISTICS: LENGTH: 62 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobactor pylori (ix) FEATURE: NAME/KEY: misc...featur.
LOCATION .62 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1800 Cys Leu Thr Arg His Arg Val Asn Lou His Ph. Ph. Thr Gly Gly Ph.
1 5 10 Trp Pro Asn Gly Ser Asp Arg Arg Ser Cys Ph. Asn Ser Ph. Lou Ala 25 Arg Ala Ang Ph. Cys Trp His His Ph. Tyr Gly Gly Ph. Ile Arg Ala 40 Lys Arg Asp Val Ser Tyr Arg Lys Val Ser Ile Lou Ser Ph.
s0 55 INFORMATION FOR SEQ ID NO:180i: SEQUENCE CHARACTERISTICS: LENGTH: 187 amino acids TYPE: amino acid TOPOLOGY: linear X\ (ii) MOLECULE TYPE: protein AME0D2 SHEET.
PCT/US 96/ 09122 IPEA/US 18 DEC 1996 1333 (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...187 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1801 Phe Leu Leu Trp Ala Gly Leu Met Ile Phe Thr Phe Val Phe Glu Tyr 1 5 10 Gly Ala Asn Val Ser .Gn Gly Thr Gly Leu Ile Phe Thr Ser Leu Pro 25 Val Val Phe Gly Gin Met Gly Ala Ile Gly Val Leu Val Ser Ile Leu 40 Phe Leu Leu Ala Leu Ala Phe Ala Gly Ile Thr Ser Thr Val Ala Leu 55 Leu Glu Pro Ser Val Met Tyr Leu Thr Glu Lys Tyr Gin Tyr Ser Arg 70 75 Phe Lys Val Thr Trp Gly Leu Val Ala Leu Ile Phe Val Val Gly Val 90 Val Leu Ile Phe Ser Leu His Lys Asp Tyr Lys Asp Tyr Leu Thr Phe 100 105 110 Phe Glu Lys Ser Leu Phe Asp Trp Leu Asp Phe Ala Ser Ser Thr Ile 115 120 125 Ile Met Pro Leu Gly Gly Met Ala Thr Phe Ile Phe Met Gly Trp Val 130 135 140 Leu Lys Lys Glu Lys Leu Arg Leu Leu Ser Ala His Phe Leu Gly Pro 145 150 155 160 Lys Leu Phe Ala Thr Trp Tyr Phe Leu Leu Lys Tyr Ile Thr Pro Leu 165 170 175 Ile Val Phe Ser Ile Trp Leu Ser Lys Ile Tyr 180 185 INFORMATION FOR SEQ ID NO:1802: SEQUENCE CHARACTERISTICS: LENGTH: 285 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...285 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1802 Glu Ser Phe Met Gly Cys Ser Phe Ile Phe Lys Lys Val Arg Val Tyr 1 5 10 Ser Lys Met Leu Val Ala Leu Gly Leu Ser Ser Val Leu Ile Gly Cys 25 Ala Met Asn Pro Ser Ala Glu Thr Lys Lys Pro Asn Asp Ala Lys Asn V 40 Gin Gin Pro Val Gin Thr His Glu Arg Met Thr Thr Ser Ser Glu His LAE
D
AMEEDED SHEET PCT/US 96/09122 1334 IPEAUS 18 DEC1996 55 Val Thr Pro Leu Asp Phe Asn Tyr Pro Val His Ile Val Gln Ala Pro 70 75 Gin Asn His His Val Val Gly Ile Leu Met Pro Arg Ile Gln Val Ser 90 Asp Asn Leu Lys Pro Tyr Ile Asp Lys Phe Gln Asp Ala Leu Ile Asn 100 105 110 Gin Ile Gln Thr Ile Phe Giu Lys Arg Gly Tyr Gin Val Leu Arg Phe 115 120 125 Gin Asp Glu Lys Ala Leu Asn Val Gln Asp Lys Lys Lys Ile Phe Ser 130 135 140 Val Leu Asp Leu Lys Gly Trp Val Gly Ile Leu Glu Asp Leu Lys Met 145 150 155 160 Asn Leu Lys Asp Pro Asn Ser Pro Asn Leu Asp Thr Leu Val Asp Gin 165 170 175 Ser Ser Gly Ser Val Trp Phe Asn Phe Tyr Glu Pro Glu Ser Asn Arg 180 185 190 Val Val His Asp Phe Ala Val Glu Val Gly Thr Phe Gin Ala Ile Thr 195 200 205 Tyr Thr Tyr Thr Ser Thr Asn Asn Ala Ser Gly Gly Phe Asn Ser Ser 210 215 220 Lys Ser Val Ile His Glu Asn Leu Asp Lys Asn Arg Glu Asp Ala Ile 225 230 235 240 His Lys Ile Leu Asn Arg Met Tyr Ala Val Val Met Lys Lys Ala Val 245 250 255 Thr Glu Leu Thr Lys Glu Asn Ile Ala Lys Tyr Arg Asp Ala Ile Asp 260 265 270 Arg Met Lys Gly Phe Lys Ser Ser Met Pro Gln Lys' Lys 275 280 285 INFORMATION FOR SEQ ID NO:1803: SEQUENCE CHARACTERISTICS: LENGTH: 351 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...351 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1803 Glu Leu Val Leu Phe Glu Lys Leu Lys Phe Phe Lys Ile Lys Lys Asp 1 5 10 Asp Giu Asn Gln Pro Glu Val Asn Leu Ash Ser Glu Ile Tyr Glu Gin 25 Phe Lys Val Phe Arg Leu Pro Leu Ile Leu Ile Gin Leu Leu Val Leu 40 Leu Gly Thr Leu Gly Tyr Phe Ala Leu Glu Asn Tyr Ser Leu Met Gin 55 Ala Phe Phe Gln Thr Thr Tyr Thr Met Thr Ala Thr Gly Phe Gly Ala 70 75 Leu Asn Glu Ser Gin Phe Gly Pro Ile Ser Ile Phe Leu Thr Ser Ile 90 Leu Met Phe Cys Gly Thr Gly Ile Ile Ala Phe Ser Val Ala Ile Leu 100 105 110 I/US 9 6 091 2.
IPEA/S 18 DEC1996 1335 Val Gly Tyr 145 Gin Ala Asn Ala Arg 225 Ser Asp Met Lys Ser 305 Ala Pro Asn Lys Tyr Val 165 Lys Leu Ile Lys Asp 245 Ser Pro Leu Leu Val 325 Gly Lys Ile Thr 150 Val Tyr Lys Leu Glu 230 Glu Pro Asp Leu Arg 310 Ile Lys Gly Thr Leu Thr Arg Leu Ile Lys Glu Lys Ala 135 Ile Val Pro Thr Pro 215 Leu Gly Thr Met Asp 295 Lys Gly Arg 120 Arg Glu Asp Tyr His 200 Val Lys Leu Lys Glu 280 Leu Leu Ile Leu Leu Leu Asn Tyr 185 Leu Asn Arg Glu Leu 265 Asn Glu Lys Thr Leu 345 INFORMATION FOR SEQ ID NO:1804: Thr 1 Lys Phe Pro Ile RA4/ Gl et 0u SEQUENCE CHARACTERISTICS: LENGTH: 105 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION 1...105 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1804 Lys Lys Leu Asn Asn Thr Leu Phe Asn Lys Gly 5 Met Phe Lys Lys Ile Ile Phe Leu Cys Val Phe 25 Val Ile Pro Pro Leu Glu Ala Met Pro Ile Leu 40 Lys Lys Asn Tyr Gln Glu Ala His Glu Lys Leu 55 Asn Arg Gln Lys Leu Thr Arg Lys Lys Ser Gly 70 75 Gly Val Gly Ala Val Glu Ala Ile Lys Asp Tyr 85 Lys Asp Trp Met Pro Arg Ser Ile EiSo SDSIET Leu Ile Leu Ile Arg Asn Tyr Arg Trp Tyr Gin Gly Phe Gly Thr Ile Leu Glu PCT/US 96/091 Z IPENUS 18 DEC 1996 1336 100 105 INFORMATION FOR SEQ ID NO:1805: SEQUENCE CHARACTERISTICS: LENGTH: 87 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...87 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1805 Ile Met Ala Cys Lys Phe Cys Pro Lys Ile Arg Lys Thr Asp Trp Ile 1 5 10 Phe Ile Leu Ile Ala Ala Leu Gly Phe Tyr Ser Val Asn Lys Leu Gly 25 Tyr Ala Pro Lys Phe Asn Thr Pro Thr Pro Lys Ser Ser Arg Pro Leu 40 Ser Arg Pro Ile Glu Lys Pro Asn Asn Met Thr Glu Glu Glu Arg Lys 55 Lys Arg Phe Ile Glu Leu Gin Lys Ala Cys Leu Leu His Lys Asp Lys 70 75 Lys Ala Cys Glu Glu Val Phe INFORMATION FOR SEQ ID NO:1806: SEQUENCE CHARACTERISTICS: LENGTH: 173 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...173 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1806 Arg Ala Ile Thr Thr Asn Gln Phe Val Gly Thr Asn Met Phe Phe Lys 1 5 10 Thr Tyr Gln Lys Leu Leu Gly Ala Ser Cys Leu Ala Leu Tyr Leu Val 25 Gly Cys Gly Asn Gly Gly Gly Gly Glu Ser Pro Val Glu Met Ile Ala 40 Asn Ser Glu Gly Thr Phe Gin Ile Asp Ser Lys Ala Asp Ser Ile Thr 55
A?
POUS 96/U912 WPEA/US 18 DEC 1996 Ilie Pro Ilie Asp Giu Ser 145 Gin Gin Gly Vai Ser Ser Ile Gin Lys 115 Gin Lys 13 0 Leu Lys Thr Asp Val Giu Gin 100 Lys Giy Gly Lys Lys Thr Asp Giy Val1 Ile Giy 165 Leu 70 Phe Phe Leu Met Ser 150 Ala Asn Vali 90 Ala Ala Gin Asn Asn 170 1337 Cys Ala Leu Ser Ser Thr Asn Lys Thr Leu 140 Ile Ile 155 Pho Asp Val Gin Tyr Ile 125 Asn Giu Lys Asn Val1 Lys 110 Ser Ph.
Ala Phe Thr Ile Gin Gly Glu INFORMATION FOR SEQ ID NO:1807: SEQUENCE CHARACTERISTICS: LENGTH: 144 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter 'pyloni (ix) FEATURE: NAME/KEY: misc-feature LOCATION .144 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1807 Ile Ser Asn Met Giu Asn Thr Pro Lys Asp 1 Glu Ser Ser Gly Gin Leu Cys Pro Giu Leu Leu Val Giu Lys Gin Tyr 130
S
Ile Lys Giu Ala Ph.
Glu Gin Leu.
Lou Lys Ala Cys 70 Arg Arg Ph.
Gly Gin Trp Ile 55 Ph.
Giu Lou Lou Leu 135 Gly Vat Thr Lou 5cr Asn Tyr Lou Gin Tyr Ph. Giu 105 5cr Ala 120 Cys Lou Ile Ala Ph.
Lou Gin 90 Val met Val Arg Asn Lou Tyr Asp 75 Trp Phe Arg Gly Ala Arg Ala Gly Ala Lou Pro Ser Tyr 140 Arg Met Val Lou Tyr Ile Ile Phe 125 Gly Ile Lou is Ala Gin Gly Vat Cys Val Tyr Lou Lys Asn His Gin 110 Sen Lou Ph. Cys Ile Asn Lou Lou Met Arg Thr Ph.
Cys INFORMATION FOR SEQ ID NO:i808: SEQUENCE CHARACTERISTICS: LENGTH: 322 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein POUS 96/O9i2 IpENJUS 18 DiEC 1996 1338 (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .322 (xi) SEQUENCE DESCRIPTION: SEQ ID, NO:i808 Pro Leu Lys 1 Lys Ilie His Leu Ile Son Lou Asp Asn Lou Phe 145 His Arg Gly Lou Phe 225 Lys Cys Pro Gin Asp 305 Lou Lou Asp so Cys Ala Thr Glu Pro 130 Lys Gin Giu Lys Giu 210 Ph.
Tyr Tyr Ph* Gin 290 Ser Lys Ile Ser Ser Val1 Pro 11s Ph.
Ile Gly Asn Asp 195 Arg Lys Lys Glu
LYS
275 met Ph.
Ser Lys 5 Cys Lou Thr Ile Asn Ser Lys Arg Lou Phe Phe Lou 100 Thr Lys Glu Ala Asp Leu Ph. Asn 165 Gly Ph.
180 Lou Ph.
Ile Lou Giu His Pro Tnp 245 Ala Giu 260 Asri Asp Gin Ser Tyr Ph.
Ala Ser Lys Val Lys Gly Giu Pro Ph.
40 Lou Asp Tyr 55 Tyr Gly Gly 70 Pro Asn Tyr Gly Asp Val Lou Lou Gly 120 Ph. Cys Asp 135 Lou Ang Ph.
150 Met Gly Ph.
Giu Lys Ile Tyr Pro Giu 200 Giu Lou Pro 215 Tyr Pro Lys 230 Arg Son Val Ala Ser Ph.
Ph. Ph. Lys 280 Ph. Lys Thr 295 Arg Ile Lys 310 Lou Val 25 Lys Ser Lou Sor Ala 105 Met Ph.
Ser Lou Ala 185 Gin Ile Ser Ser Trp 265 Giu His Asn Lou 10 Thr Lys Ile Lou Lys 90 Ser Val Cys Gin Val1 170 Lou Cys His I16 Ser 250 Lou Arg Ile Ile Gly Ala Asn Lou Giu Gin Ph, Ala Sen Glu Ser Tyr Val Lou Cys 75 Ile Ile Ser Ala Tyr Ph.
Arg Asp Thr 125 Glu Ari Thr 140 Asn Glu Lou 155 Ala Asn Lou Glu Ph. Lou Lou Ile Asn 205 Tyr Asn Cys 220 Ile Met Lou 235 Lou Asn Gly Ala Asn Lou Lou Glu Mot 285 Arg Son Lys 300 Lou Lys Lys 315 Ile Gin Lou Lou Arg Ilo Ala 110 Ph.
Cys Lys Asp Lys 190 Met Tyr His Arg Ph.
270 Ala Thr Val Val Asn GiU Asn Lou Asp Lou Ser Lys Arg Lou 175 Thr Val Sor Pho Lou 255 Cys Lys Ile Ph.
Tyr Lys Ph.
Glu Lou Val Asp His Asn Ile 160 Trp Arg Ph.
Asp I1e 240 Ile Thr Asp Arg Glu 320 INFORMATION FOR SEQ ID NO:1809: SEQUENCE CHARACTERISTICS: LENGTH: 566 amino acids TYPE: amino acid TOPOLOGY: linear MOLECULE TYPE: protein HYPOTHETICAL: YES (ii) (iii) POUS 96/O0912.a IPENUS 18 0E 0'196 1339 (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .566 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1809 1Lys Lys Ph. Ser Asn Ser Leu Leo Ph.
Ph.
Val1 Leu Ile Asp Ser Leu 145 Ilis Asn1 Phe Ph.
Tyr 225 Val1 Gly Arg Ile 305 Ile Gin Ser C lo Lys 385 Asp Phe Asp K u T ~V-o Lys Leu Ser so Tyr Gbu Phe Thr Tyr 130 Ile Ala Ile Ser Asp 210 Leu Leu Tyr Giu Ser 290 Ser Asp Ile Lys Leu 370 Asn Ang Sen Tyr Ph.
Leu Ph.
Trp Thr Leu 115 Lys Ala Se r Lys Leu 195 Arg Pro Val1 Ser Arg 275 Lys Asp Ile Val1 Asn 355 Val1 Ph.
Ph.
Asn Val Ph.
Cys Sen Gly Leu Leu 100 Leu Asn Ile Val H is 180 Ser Gin Ser Ile Val 260 Glu Glu Ala Ph.
Asp 340 Arg Lys Ile Pro Leo 420 Asn Ala Asn Lys Cys Ph.
Ph.
Ala Tyr Lys Leu 165 Leo Leu Gin Asp Gly 245 Pro Arg Ala Glu Lys 325 Gbu Tyr Ph.
Val1 Lys 405 His Ser Sen Ala Gly Ala Ile Met Thr Leu Ile 150 Gly Thr Ala Ala Tyr 230 Glu Asn Glu His Thr 310 Arg Trp Tyr Tyr Ph.
390 Ser Ala Leu Sen Leo Ph.
55 Leu G iy Ph.
Asn Leo 135 Ile Leu Lys Ang Ile 215 Leo Ser Asn Ser Thr 295 Thr Ser Gly Ile Ser 375 His Ph.
Ser Tyr Lys Val Ser 40 Leo Ile Ser Lys Ser 120 Tyr Arg Ser Asn G ly 200 Lys Ser Ala Pro Asn 280 Ser Lys His Ile Leo 360 Lys Leu Ala Ser Tyr Gly Thr 25 Asn Gly Pro Gly Met 105 Sen Tyr Ph.
Ile Asp 185 Ph.
Ph.
Ser Ser Leu 265 Msn Asp Pro Tyr Thr 345 Gly Asn Leu Lys Asp 425 Asn Gin Lys Lys Thr Leu Asp Glu Lys Ala Tyr Lys Msn Ala Ph, Leo Ile Lys Lys Ang Leo 75 Ile Ile Ph. Ser Pro Ph. Ser Lys Glu Thr Met Ala 125 Ala Leo Ile Leu 140 Arg Ala Leu Val 155 Leo Thr Ile Gly 170 Ala Ile Leo Lys Tyr Ser Ala Tyr 205 Tyr Sen Ph. Leo 220 Thr Gly Asp Ile 235 Arg Asn Ph. Met 250 Cys Gbu Arg Thr Leo Ph. Val Ph.
285 Val Phe Glu Ser 300 Trp Tyr His Tyr 315 Glu Thr Ph. Trp 330 Gin Asn Leo Vat Asn Tyr Gly Ala 365 Val Gin Pro Gin 380 Gly Ser His Ser 395 Ph. Lys Pro Sen 410 Arg Asp Lys Gin Asp Ph. Val Leo Met Phe Sen Gly Lys Val Gly 110 Ph.
Ile Pro Ser Arg 190 Leo Asn Sen Gin Ang 270 Sen Leo His Leo Sen 350 Tyr Leu Tnp Asp Ile 430 Asn Lys Leu Asp Ph.
Tyr Ala Leo Ile Ala Gly Val 175 Sen Ser An Asn Leu Gin Asp Leo Asn Giu 335 Asn Asp Lys Tyr Leo 415 Val1 Gly Ph.
Met Leo Val Sen Glu Ile Lys Leo Val 160 Arg Leo Leo Leu Val 240 Tyr Ala Thr Msn met 320 Lys Arg Glu Sen Ala 400 Sen Ala Ile POUS 96/09122 IPENUS 1 8UIic. 2 1996 1340 Phe His 465 Ser Phe Asn Val Pro 545 Asn 435 Lou Gin Ala GiU Pro 52.5 Ile Phe Asp Lys Ile Leu 485 His Met Thr Ala Thr 565 Asp Phe 470 Giu Pro Ser Lys Gin 550 Lys Lys 455 Glu Ile Glu Asp Asp 535 Arg 440 Asp Ser Pro Lys Asp 520 Glu Lys Aia Gly Phe Vai 505 Leu Ile Arg 445 Tyr Gly Val Lys Lou 525 Asn Tyr Leu His Ser Asn 510 Lou Lou Gly Ser Ser Asp 495 Ala Pro Phe Ser INFORMATION FOR SEQ ID NO:1810: Wi SEQUENCE CHARACTERISTICS: LENGTH: 74 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Heiicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1 .74 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1S10 Lys Sen Phe Met Pro Pro Thr Arg Pro Gin Ala Ser Ile Lou Arg Lou 1 5 10 is Thr Leu Lys Asn Pro Lou Sen Met Leu Son Arg Tyr Sen Leu Cys Leu 2S Lou Lys Lys Thr Arg Lou Gin Thn Thn Sen Asn Sen Aia Pro Lys Ala 40 Cys Lou Ile Ala Gly Leu Lou Lys Lys Ser Lys Pro Phe Ile Lou Asn 55 Thr Lou Lys.Ii. Arg Sen Lou Leu Lys Pro INFORMATION FOR SEQ ID NO:1811: Ci) SEQUENCE CHARACTERISTICS: LENGTH: 85 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
vi) ORIGINAL SOURCE: CA) ORGANISM: Helicobacter pylori
LU
PCT/US 96/0912.
IPENUS 18 D Ci996 1341 (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...85 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1811 Thr Ser Ala Ser Arg Val Ala Lys Asp Ile Ile Se 1 5 10 Leu Cys Ala Arg Lys Phe Arg Arg Leu Tyr Ala Let 25 Glu Met Leu Ile Arg Ile Gly Ser Tyr Gln Met Gl 40 Leu Asp Glu Ala Ile Lys Lys Lys Ala Leu Met Glu 55 Gin Asp Glu Asn Ala Leu Gin Pro Phe Glu Gin Ser 70 75 Glu Glu Ile Leu Arg INFORMATION FOR SEQ ID NO:1812: SEQUENCE CHARACTERISTICS: LENGTH: 93 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION 1...93 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1812 Asp Lys Arg Asn Ile Met Glu Ser Gin Leu Met Lys 1 5 10 Thr Tyr Lys Ile Thr Leu Met Ile Ser Leu Pro Val 25 Leu Val Val Gly Leu Leu Val Ser Ile Phe Gin Ala Asn Glu Met Thr Leu Ser Phe Val Pro Lys Ile Leu 55 Val Leu Ile Leu Thr Met Pro Trp Met Thr Asn Met 70 Thr Lys Thr Leu Ile Lys Leu Ile Pro Lys Ile Ile r Glu Ser Gin Asn u Leu Lys Glu Asn r Asn Asp Lys Glu Gin Phe Leu Val Phe Gin Gin Leu Ala Ile Leu Ala Thr Gin Val Ile Leu Asp INFORMATION FOR SEQ ID NO:1813: SEQUENCE CHARACTERISTICS: LENGTH: 261 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES PCiT/US 96/09122 1342 PE/S 18 DEC 1996 (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...261 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1813 Lys Met Leu Glu Thr Thr Ile Asp Phe Ser Arg Tyr Ser Ser Val Lys 1 5 10 Ile Gly Ala Pro Leu Lys Val Ser Val Leu Glu Asn Asp Asn Glu Ile 25 Ser Gin Glu His Gin Ile lie Gly Leu Ala Asn Asn Leu Leu Ile Ala 40 Pro Asp Val Lys Asn Leu Ala Leu Leu Gly Lys Asn Tyr Asp Tyr Ile 55 Cys Asp Lys Gly Glu Trp Val Glu Val Gly Gly Ala Ala Asn Ala Ser 70 75 Lys Ile Phe Asn Tyr Phe Arg Ala Asn Asp Leu Glu Gly Leu Glu Phe 90 Leu Gly Gin Leu Pro Gly Thr Leu Gly Ala Leu Val Lys Met Asn Ala 100 105 110 Gly Met Lys Glu Phe Glu Ile Lys Asn Val Leu Glu Ser Ala Cys Val 115 120 125 Asn Gly Glu Trp Leu Glu Lys Glu Ala Leu Gly Leu Asp Tyr Arg Ser 130 135 14Q Ser Gly Phe Asn Gly Val Val Leu Arg Ala Arg Phe Lys Lys Thr His 145 150 155 160 Gly Phe Arg Glu Gly Val Leu Lys Ala Cys Lys Ser Met Arg Lys Ser 165 170 175 His Pro Lys Leu Pro Asn Phe Gly Ser Cys Phe Lys Asn Pro Pro Asn 180 185 190 Asp Tyr Ala Gly Gin Ala Phe Arg Gly Arg Gly Leu Lys Gly Leu Leu 195 200 205 Ser Lys Lys Ser Gly Ala Leu Pro Lys Gin His Ala Asn Phe Leu Val 210 215 220 Asn Leu Gly Gly Ala Glu Phe Glu Glu Ala Leu Asp Leu Ile Glu Leu 225 230 235 240 Ala Lys Thr Arg Val Leu Gin Giu Tyr Gly Ile His Leu Glu Glu Glu 245 250 255 Val Lys Ile Leu Arg 260 INFORMATION FOR SEQ ID NO:1814: SEQUENCE CHARACTERISTICS: LENGTH: 90 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...90 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1814 POUS 96/O91ad.
APNUS 18 DEC 1996 Leu Ile Ser Giu Ala Lys Glu Ala Ile Gly Gly Val1 His Asn Glu Tyr Ilie Pro Met Gly Leu Arg 70 Tyr Leu Phe Asp Met Met Ala 25 Tyr Asp Gin Asn Thr Ala Asn Gin Glu Glu Val Ile 1343 Ala Ser Lys Ala Met Leu Lys Val Ala Phe Gly Val.
Thr Pro Lys 75 Gin Thr Gly Ile Ala Tyr Ser Val Thr Arg Tyr Asp Leu Met Trp INFORMATION FOR SEQ ID NO:1815: Ci) SEQUENCE CHARACTERISTICS: LENGTH: 377 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .377 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1815 Lys Ala Giu Thr Ile Lys Asn Val Val Ala 145 Ile Ph.
Asn Pro Val1 225 Glu Glu Leu Thr Thr Leu Leu Gly Lys Ile 130 Ph.
Glu Glu Glu Gin 210 Leu Phe I le Glu Gly Lys Lys
LYS
Gin Lou 115 Giu Asp Ala Thr Aen 195 Thr Asp Thr Thr Ala Lou Msn Arg Ph.
Lou 100 Ser Thr Ser Thr Leu 180 Lys Ala Ser Asn Met Aen Lau Thr Ala Ser Thr Ph.
Ile Lau Sen 165 Asn Ph.
Glu Gin Ser Arg Glu Giu Tyr Ala 70 Son Ile Thr Pro Lys 150 Thr Lys Lys Giu Ser 230 Pro Lys Lys Gly Ala~ 55 Aen Lou Glu Asp Lye 135 Ile Ser Ile Asp Ph.
23.5 Trp Thr Lou Ph. Ile Pro Asf Thr 40 Thr Lou Ser Asn Ala 120 His Asp Ile Lys His 200 Thr Gly Asp Gly 25 Gin Tyr Ph.
Pro Ph.
105 Gln Ser Pro Ser Thr 185 Glu Aen Asp Cys Ph.
Thr Asn Thr Val 90 Lou Gly Lys Tyr Asp 170 Asn Aen Lau Ala Asp Ph.
Gin Asn 75 Arg Pro Msn Ile Thr 155 Ala Leu His Met Ile 235 Asn Leu Leu Lou Ile Glu Ala Glu Lys Ang Lou Pro Thr Ala Glu Ala Val Leu Tyr Tyr Asn Lou 110 Val Ile Asp 125 Val Leu Pro 140 Lou Pho Lou Asn Thr Gin Val Val Asn 190 Trp Giu Ala 205 Leu Asn Met 220 Leu Aen Ala Asp Pro Ser Ph.
Gly His Asp Ile Met Msn Leu Gly Pro Ang 175 Tyr Phe Ile Pro Lys Ser Pho Thr Thr Ser Tyr Asn Gly Glu Lys 160 Val Arg Thr Ala Pho 240 Cys AME~W :~r POUS 96/O91a iPEMJS 18 DEC 1996 1344 Val Tyr Asp Ser 305 Leu Asp Ph.
Arg Asn Val Leu 290 Asp Gly Lou Ser Val 370 Gly 260 Asn Vat Thr Vat Thr 340 Thr Vat Gly Asp Leu 295 Asn Ala Lou Tyr Asp 375 Leu Ile 280 Lys Asn Leu Glu Oty 360 Val Ser Lys Gly Gly 315 Lys Arg Gly Asp 270 Asn Gly Tyr Phe Leu 350 Thr 255 Gin Lys Leu Gly Gly 335 His INFORMATION FOR SEQ ID NO:1816: SEQUENCE CHARACTERISTICS: LENGTH: 216 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein Ciii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylonri (ix) FEATURE: NAME/KEY: misc-feature LOCATION .216 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1816 Ile Met Gly Vat Gly Glu Lys Glu Glu Ala Met Thr Asp Ala Val Ph.
Pro Ile 145 Lys Pro Val Lou Leu so Val Lys Ph.
Ser Lou 130 Ala His Phe Ile Lou Cys Ser Glu Gly Val1 115 Lou Gly Ala Asn Thr Asn Val Asp Asp Sor 100 Asn Lys Arg Lou Val Oty Gin Ala Ser His Vat Ph.
Asn Val Glu 165 Gln Ala Gly Lou Msn 70 Cys Glu Phe Lys Ser 150 Ala Val Sor Tyr Asn 55 Ala Asp Asp Ala Pro 135 Met Tyr Cys Ser Lys 40 His Lou Val Thr Lou 120 Tyr Lou So r Leu Gly 25 Vat Ala Lys Lou Pro 105 Cys Ser Ph.
Asp Ile 185 Asn Lys Ile Tyr Lou Gtu Ile 90 Ile Glu Lys Lou Ala 170 Giu Asp Lys Glu Ser Gin O ty Ala Cys Val 75 Msn Glu Val It, dly 155 Lou Pro Glu Lou Lou Glu Phe Ser Glu Val Ph.
140 His Arg Gly Arg Giu Sor Cys Lou Ala Val1 Gtn 125 Asn Tyr Lou Pro Lys 205 Cys Arg Val Asn Gly Lys 110 Lou Lou Ser Glu Val1 190 Asp Lys Vat1 Vat Lou His Ala Asp Ile Ite Son Tyr Gly Lys Gin Cys Lou Sor Ser Ala Sen 160 Lou Lys 175 Lys Sen Son Val 180 Asn Trp Giu Lys Thr Ala Ph. Giu 5w$I609162 1345 Tyr Ala Leu Glu Val Asn Ala Ala 210 215 INFORMATION FOR SEQ ID NO:1817: Ci) SEQUENCE CHARACTERISTICS: LENGTH: 256 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .256 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1S17 1Asp Sen Asn Met Arg Ile Ala Asn Val1 Leu Ile Asp 145 Ile Leu Ile Val Leu 225 Ile Ph.
Lys Gin Lys Leu Asp Gin Ile Ile Gly Ile Lys 195 Lou Asn Asri Arg Thn Asn Glu Gin Lys Aia 100 Leu Lys Gin Asp Asp 180 Lou Ser Ala Gly Ser Ang Giu Ser Arg Asp Giu Gin His Ser 165 Ile Giy Gin Giu Ala 245 SSer Ala Ph. Ile Cys His Asn Leu Ile Tyr Arg Tyr 70 Asp Ile Lys Val Asn 150 Leu Asp Ser Thr Leu 230 Tyr Leu Gly G lu Lys Lys Giu Ile Giu 135 Thr Son Arg Ph.
Lys 215 Son Arg Lou Ile Trp Gin 75 Lys Ile Lou Lou Thr 155 Lou Giu Glu Giu Giu 235 Asp Lys Phe Ang Ile Arg Pro Ser Asn 140 Leu Tyr Gin Gin Thr 220 Ile Lou Ala Val Asp Giu Asn Thr Pro Lys 125 Tyr Asp Val Ph.
Ala 205 Pro Lou Lys Met Leu Val1 Lys Lys Ile Lys 110 Asp Ala Ph.
Thr Leu 190 Lou Lys Thr Lys Val1 is Ser Ala Lys Ile Lou Asp Ile Lou Thr Ph.
175 Asn Glu Giu Gly Gly 255 Leu Giu Asp Lys Ala Ser Lou Val1 Ile Ph.
160 Asn His Trp Ala Cys 240 Arg INFORMATION FOR SEQ ID NO:1818: SEQUENCE CHARACTERISTICS: LENGTH: 196 amino acids TYPE: amino acid TOPOLOGY: linear U A jj AIM i" D -Z*t P 96/09122 18 DE 1996 1346 (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...196 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1818 Gly 1 Gin Met Ile Asp Thr Thr Ala Leu Ile 145 Asn Ile Gin Asn Ala Arg Thr 5 Trp Asp Cys Gly Asn Phe Phe Val Thr Tyr Ser Ala lie Val Gin Val Gly Leu Leu Phe Phe Gly Leu Asp 100 Ile Asn Thr Val 115 Asp Asp His Lys 130 Ile Trp Leu Ala lie Leu Lys Ile 165 Glu Gly Ile Leu 180 His Trp Val 195 Cys Leu Gly Leu Ser 70 Gly Trp Pro Val Trp 150 Pro Thr Ile Thr Gly His 55 His Phe Arg Ala Leu 135 Gly Leu Ala Val Ile Cys 10 Lys Val Asp Leu Ser Ile 40 Pro Thr Ala His Leu Thr Thr Tyr Leu 90 Pro Tyr Ser 105 Ala Ile Leu 120 Gly Ile Thr Val Leu Trp Gly Lys Phe 170 Trp Ile Pro 185 Trp Asp Cys Pro Lys Ser Val Cys Asn Pro Val Glu Ser Phe Tyr 75 Tyr Ala Ala Trp Tyr Ser Ser Hid Tyr 125 Glu Gly Asp 140 Leu Thr Ala 155 Thr Pro Trp Ala Trp Leu Asn Ala Val Ala Pro Asn Phe Asp Trp Ile Ala 175 Phe Gin Val Val Glu Ala His Val Me Ala Glu 160 Ile Ile INFORMATION FOR SEQ ID NO:1819: SEQUENCE CHARACTERISTICS: LENGTH: 640 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...640 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1819 Ser Ile Cys His Glu Tyr Leu Lys Val Asn Leu Gin Glu Lys Leu Ala 1 5 10 Gly Phe Arg Asp Phe Val His Tyr Asn Glu Asn Ala Lys Asp Ser Leu 25 2s 6 LkN 9
I~
2 1347 Pro Leu Ala Leu Val Leu Glu Asp Glu Gly Lys Ser Lys Gin 130 Lys Glu 145 Gly Trp G1n Asn Phe Leu Glu Val 210 Ala Tyr 225 Ala Ser Glu Met Lou Ser Ile Asp 290 Val Glu 305 Val His Pro Ser Ala Giu Gin Asn 370 His Thr 385 Leu Thr Asp Arg Lou Lys Glu Gin 450 Leu Val 465 Leou Phe Lys Glu Ile Thr Pro Asn 530 Lys Tyr Ser Leu Leu Gin 115 Lys Phe Asp His His 195 Gin Val Ser Gin Asp 275 Glu Gly Lou Phe Asp 355 Pro Lys LyS Lys Ala 435 Lys Val Gin Lys Pro 515 Ser Ala Leu Phe Leu Ser Gly Val Asp Ala 40 Tyr Phe Lys Lys 100 His Lys Trp Ile Thr 180 Val Lou Ala Ile Lys 260 Tyr Phe His Val Lys 340 Ser Glu Met 11e Ile 420 Asn Asp Ile Asn Arg 500 Val Ala Leu Val Arg Tyr Met Glu Thr Asn 165 Leu Leu Phe Asp Ser 245 Arg Arg Gin Leu Leu 325 Ala Ser Gly Ser His 405 Tyr Glu Lou Gin Val 485 Leu Giu Leu Glu Asn 70 Tyr Lou Gin Val Lys 150 His Ile Ile Lou Pro 230 Tyr Ala Lys Val Asn 310 Ala Gin Ser Ile Val 390 Ala Asn Met Ile Asp 470 Lys Ile Asn Val Lys 55 Leu Ala Asn Asp Lys 135 Ser Lys Cys Gin Leu 215 Ala Gly Asp His Lou 295 Thr Thr Ile Val Phe 375 Pro Giu Gly Arg Val 455 Lou Ser Arg Ile Ile Ile Glu Glu Val Phe 120 Arg Ser Giu Asp Asn 200 Asp Lou Ile Arg Giu 280 Phe Leu Gin Ala Lou 360 Asn Lys Phe Glu Lou 440 Giu Asn Ala Ser Lou 520 Asp Met Ser Phe Glu 105 Ala Glu Gin Val His 185 Leu Tyr Glu Thr Phe 265 Lys Ser Leu Thr Asn 345 Gly Asn Ala Asn Thr 425 His Phe Ala Asn Phe 505 Ser Asn Arg Glu Phe 90 Ile Asp Leu His Cys 170 Ser Ala Lys His Phe 250 Lys Met Asp Lys Met 330 Arg Asp Asn Pro Gin 410 Pro Lou Giu Arg Lys 490 Asp Val Lou Lys Phe Lys 75 Lys Ile Lys Lys 2 Glu A 155 Phe Gly Phe Glu C Ala 235 Leu Gin Pro Asn Lys 315 Arg Ile Asp Gly Asp.
395 Arg Lou Gly Ser Ile 475 Glu Ala Lou Asn Ser Gly Asn Asp Ser Ile Asp Val Lys Ser Tyr Gly 220 Arg Lys ?he Arg Lys 300 Gly Gly Ala Ala Gly 380 Asp Asn Lys Lys Asn 460 Ala Leu Gir As; Glt 54C Phi Lou Ser Asn Arg Asp Lys 125 Lou C Ser Ile C Gly Tyr 205 Val Lou Trp Asn.
Leu 285 Ser Arg Thr Lou Ala 365 Asn.
Phe Lou Met Lys 445 Glu Lou Val Lys Thr 525 Ala Leu Ser Lys Gin Thr Gin 110 Ala Gin Val, Gly .ys 190 Asp Glu Val Leu Val 270 Ile Thr Ser Asp Pro 350 Cys Arg Lys Ala Pro 430 Val Ser Met Phi Glu 510 Ala Ly Gi Lys Asn Ser Ser Gly Tyr Arg Pro Asn C 175 Ser Pro Phe Ser Cys 255 Lys Val Lys TyrI Ile 335 Met Glu Lys Ser Pro 415 Asp Asp His Lys Cys 495 Tyr Met s Glu u Lys Asp Gliy Ala s0 ?he Ile Tyr Asp Val 160 Glu Asn Asp Asn Val 240 Asp Asp Val Ala Gly 320 Asn Asp Ile Tyr Phe 400 Ile Thr Tyr Leu Lou 480 Asn Gly Asn Lou Ala 535 His Asp Lys Val Gly Ala Glu Lys Lou AMEi~D~o S~ET PCT/US 9 6 /0912.
IPENUS 18 DEC1996 1348 545 550 555 560 Ile Asp Asn Glu Gln Tyr Cys Val Ile Phe Ala His Asp Phe Arg Gin 565 570 575 Ile Lys Thr Asn Tyr His Phe Asp Lys Leu Lys Glu Leu Leu Asn Asn 580 585 590 His Phe Lys Gin Cys Leu Ala Phe Arg Cys Asn Gly Glu Asn Leu Asn 595 600 605 Ala Ile Lys Ser Asp Leu Pro Pro Pro Ser Lys Leu Asn Val Leu Leu 610 615 620 Ile Glu Leu Ser Lys Asp Ser Val Thr Glu Phe Arg Pro Phe Ser Leu 625 630 635 640 INFORMATION FOR SEQ ID NO:1820: SEQUENCE CHARACTERISTICS: LENGTH: 88 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...88 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1820 Arg Pro Asn Leu Ser Ser Gin Phe Leu Tyr Thr Glu Met Leu Ser Leu 1 5 10 Lys Leu Thr Tyr Glu Ser Thr Leu Gin Gin Asp Leu Lys Lys Ile Leu 25 Gly Ile Glu Glu Val Ile Met Leu Ser Thr Ser Pro Met Glu Leu Arg 40 Leu Ala Asn Gin Lys Leu Gly Asn Arg Phe Ile Lys Thr Leu Gin Ala 55 Met Asn Glu Leu Asp Met Gly Ala Phe Phe Asn Ala Tyr Ala Gin Thr 70 75 Thr Gin Arg Ser His Pro Cys His INFORMATION FOR SEQ ID NO:1821: SEQUENCE CHARACTERISTICS: LENGTH: 223 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...223 PCT/US 9 /09122 IPEA/US 18 DEC1996 1349 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1821 Glu Lys Ser Thr Ser Asn Leu Lys Lys Pro Ser Val Trp Arg Ser Lys 1 5 10 Leu lie Cys Lys Ile Ala Thr His Lys Ala Arg Ser Ile Gly Leu Cys 25 Val Lys Pro Lys Ser Met Lys Glu Lys Leu Arg Gly Ala Met Val Asn 40 Ile Leu Arg Ile Lys Met Ile Glu Ile Ser Glu Trp Leu Gin Lys Leu 55 Asp Asp Ala Leu Asp Lys Val Val Ala Lys Lys Glu Pro Glu Ser Phe 70 75 Leu Lys Pro Ile Ile Ser Pro Ile Glu Asp Tyr Gin Lys Ser Val Arg 90 Gin Ile Gin Ala Gin Phe Thr Asp Ala Pro Lys Phe Asn Glu Glu Gly 100 105 110 Ala Tyr Pro Gin Phe Leu Ser Cys Gly Leu Leu Gin Val Arg Gly Lys 115 120 125 Asn Gly Ala Asn Met Glu Phe Leu Leu Pro Lys Val Tyr Pro Phe Pro 130 135 140 Pro Lys Ser Leu Tyr Ile Glu His Glu Lys Asp Gly Gin Phe Leu Arg 145 150 155 160 Glu Met Leu Met Arg Leu Leu Ser Ser Ala Pro Leu Val Gin Leu Glu 165 170 175 Val Ile Leu Ile Asp Ala Leu Ser Leu Gly Gly Ile Phe Asn Leu Ala 180 185 190 Arg Arg Leu Leu Asp Lys Asn Asn Asp Phe Ile Tyr Gin Gin Arg Ile 195 200 205 Leu Thr Glu Ser Lys Glu Ile Giu Giu Ala Leu Lys His Leu Pro 210 215 220 INFORMATION FOR SEQ ID NO:1822: SEQUENCE CHARACTERISTICS: LENGTH: 113 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...113 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1822 Thr Trp Val His Phe Leu Thr Leu Thr Leu Lys Gin Pro Lys Asp Pro 1 5 10 Thr His Ala Thr Ser Tyr Gly Val Phe Ala Ala Ser Leu Asn Met Glu 25 Leu Lys Lys Ala Leu Arg His Tyr Leu Tyr Ala Gin Thr Ser Asn Met 40 Val Ile Asn Cys Val Lys Ser Val Pro Leu Ser Gin Asn Asp Gly Gin 55 Lys Ile Leu Leu Ser Leu Gin Ser Pro Phe Asn Gin Leu lie Glu Lys 70 75 Thr Leu Glu Leu Asp Glu Ser His Leu Cys Ala Ala Ser Val Gin Asn 90 \Asp Ile Lys Ala Met Gin His Glu Ser Leu Tyr Ser Arg Leu Tyr Met 13S0 100 ios 110 Ser INFORMATION FOR SEQ ID NO:1823: SEQUENCE CHARACTERISTICS: LENGTH: 156 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .156 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1823 Arg Ala Ser Met Lys Asn Phe Ser Pro Leu Tyr Cys Leu Lys Lys Leu 1 S 10 1s Lys Lys Arg His Leu Ile Ala Leu Ser Lou Pro Leu'Lou Ser Tyr Ala 25 Asn Gly Phe Lys Ile Gin Glu Gin Ser Lou Asn Gly Thr Ala Leu Gly 40 Ser Ala Tyr Val Ala Gly Ala Arg Giy Ala Asp Ala Ser Phe Tyr Msn 55 Pro Ala Asn Met Gly Ph. Thr Asn Asp Trp Gly Glu Asn Arg Ser Giu 70 75 Phe Glu Met Thr Thr Thr Val Ile Asn Ile Pro Ala Ph. Ser Ph. Lys 90 Val Pro Thr Thr Asn Gin Gly Leu Tyr Ser Val Thr Ser Lou Giu Ile 100 105 110 Asp Lys Ser Gin Gin Asn Ile Leu Gly Ile Ile Asn Thr Ile Giy Lou 115 120 -125 Gly Asn Ile Lou Lys Ala Leu Gly Asn Thr Ala Ala Thr Asn Gly Leu 130 135 140 Ser Gin Gly Ile Msn Arg Val Gin Gly Vai Met Asn 145 150 155 INFORMATION FOR SEQ ID NO:1824: SEQUENCE CHARACTERISTICS: LENGTH: 217 amino acids TYPE: amino acid TOPOLOGY: iinear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .217 POUS 9 6/09122.Z iPEA/LC '~996 1351.
(xi) SEQUENCE DESCRIPTION: SEQ ID NO:i824 Ala Asp Arg Giu Asp Lys Leu Ser His Ser Ile Ile Met Arg Tyr Phe 1 5 10 Arg 5cr Ala Phe Leu Leu Phe Phe Met Thr Leu Phe Phe Val Ser Cys 25 Lys His Pro Phe 5cr Lys Gin Thr Pro Lys Thr Lys Giu Arg Ile 40 Arg Gin Glu Giu Ala Asn Lys Lys Arg Giu Giu Thr Leu Asn Ala Leu s0 55 Arg Gin Phe Arg Lau Ile Tyr Ile Asn Thr Pro Val Phe Arg Phe Tyr 70 75 Asp Tyr Gly Thr Ilie Lys Thr Asp Lys Asp His Asn Thr Giu Val Thr 90 Leu Tyr Lys Leu Ser Gin Lys Val Gly Asp Ile Tyr Met Thr Lys Arg 100 105 110 Ilie Cys Phe Ser Gin Lys Cys Ser Aia Lys Trp Ile Ala Ala Arg 115 120 125 Asp Leu Phe Gly Lys Val Ser Tyr Gly Asp Leu Phe Asp Asp Ile Val 130 135 140 Leu Gly Arg Asp Ile Phe Lys Gly Leu Giy Lys Arg His Leu Thr Pro 145 150 155 160 Glu Tyr Val Ile Gin Arg Phe Gin Lys Ser Gly Glu Ile Ile Leu Tyr 165 170 175 Glu Arg Lys Asn Giy Leu Ile Ser Phe Gin Asn Leu Thr Gin Lys Ile 180 185 190 Ala Ile Arg Ile Glu Pro Tyr Giu Pro Ser Leu Gin Asp Leu Giu Asp 195 200 '205 Asn Giu Asn Aia Asp Ser Giu Leu Gin 210 215 INFORMATION FOR SEQ ID NO:1825: SEQUENCE CHARACTERISTICS: LENGTH: 236 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .236 (xi) SEQUENCE DESCRIPTION: SEQ ID, NO:1825 Giu Ile Ala Giu Ilie Val Ser Gin Trp Thr His Ile Pro Phe Gin Lys 1 s 10 is Met Phe Gin Sen Glu Lys Asn Ang Val Leu Asn Ile Glu Sen Giu Leu 25 Gin Lys Arg Val Val Gly Gin Giu Lys Ala Leu Lys Ala Ile Ala Lys 40 Ala Ilia Lys Arg Asn Lys Ala Gly Leu Ser Asp Ser Asn Lys Pro Ile 55 Gly Ser Phe Leu Phe Leu Gly Pro Thr Gly Val Gly Lys Thr Giu Ser 70 75 Ala Lys Ala Leu Ala Gin Phe Leu Phe Asp Ser Asp Lys Asn Leu Ile 90 \Arg Ile Asp Met Ser Giu Tyr Met Giu Lys His Ala Ile Sen Ang Leu IN g! n, r n,.Q w rv-,
POUS
IPEAIUS
0/6/09az ibtEC 1996 1352 Gly G iu 130 GiU GlU Thr G iu Arg 210 Ser Ala 115 Ala Lys Gly Ile Asp 195 Gin Phe 100 Ala Val Ala His Leu 180 Leu Phe Asn Pro Arg His Leu 165 Ile Ser Phe Ala Gly Arg Pro 150 Thr Leu Glu Lys Leu 230 Tyr Lys 135 Asp Asp Thr Ala Pro 215 Asp 105 Gly Tyr Tyr Ser Phe Asn Lys Gly 170 Asn Val 185 Lys Gin Phe Lou His Ala Giu Val Phe 155 Val Ala Lys Asn Ile 235 Giu Val 140 Leu Arg Ser Ala Arg 220 Ile Gly 125 Leu Leu Val Gly Ile 205 Leu 110 Gly Lou Gin Asp Ala 190 Lys Asp INFORMATION FOR SEQ ID NO:1826: SEQUENCE CHARACTERISTICS: LENGTH: 259 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyiori (ix) FEATURE: NAME/KEY: misc-feature.
LOCATION .259 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1826 ValI Lys Ala Pro Ile Phe Gly Trp Phe Giy 145 Leu Phe Arg Asp Pro Cys Ser Lou Val Val Lou 130 Leu Giy Thr Phe Trp Lou Val Lou Lys Gly Asn 115 Gly Ala Met Ser Cys Met Lou Lou Giu.
Sor Met 100 Tyr Vai Ser Ser Ile 180 Val1 Tyr mot Thr Pro Asp Lou Ser Ile Phe Lys Ph.
165 Val Val Ser Lys Phe Asp Ser Lou Lou Ile 55 Ile Lys 70 Met Ph.
Met Ala Ala Gly Arg Phe 135 Ser Asn 150 Ala Leu Ile Met Phe Val Lys Asn Lou 40 Pro Asp Val Lys Gly 120 Ala Ser Gly Sor Met 200 TyrJ Thr 25 Ala Ala Gly Val Lou 105 Ile Lou Met Trp Ala 185 G ly Lye Lys Thr Ile Ile Lou Lye Lou Giy Tyr Lys Gly 90 Ile Val Lou Gin Thr 170 Ser Lou Ile Ile Met Ala Ph.
His Ile Tyr Arg 155 Pro Lys Ala TAsn Lou Ser Lys Ser Ser Lou Lys 140 Phe Cys Asp Ile Lou Thr Tyr Arg Lou Pho Ph.
125 Thr Tyr Ile Ala Pro Ph.
Ph.
Ile Val Val Sor 110 Gly Gin Pro Gly Tyr 190 Phe Glu Thr Lou Sor Ser Gin Ser Val Ph. Lou Ph. Sor Leu His Sor Ala Phe Lou 160 Pro Ile 175 Gly Lou Val Lou Met Lou Met 195 AWonlrn ounni PE/US 1353 Ala Leu Met Leu Glu Arg Ala Leu Leu Phe Leu Lys Ser Leu Arg 210 215 220 Tyr Asn Arg Ala Ile Glu Ile Val Ser Gly Leu Val Leu lie Leu 230 235 240 Gly Ile Leu Ile Met Thr Asn Ser Leu Glu Ser Leu Thr Asn Phe 245 250 255 Gin Asn 9 6 /091zz2.
-C 1996 Val Lys 225 Met Leu INFORMATION FOR SEQ ID NO:1827: SEQUENCE CHARACTERISTICS: LENGTH: 198 amino acids" TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION 1...198 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1827 Ile Gly Gly 1 Val Gly Phe Ala His Ala Phe Leu Tyr Phe Met Lys Phe Phe Ile Gly Asn 145 Glu Asn Gly His Asp Leu Leu Cys 130 Asn His Leu Val Asn Lys Lys Ala 115 Glu Thr Ala 5 Gly Val Phe Gly Ser Tyr Leu Gly Met Leu Ser His 70 Leu Leu Lys Thr Lys Phe 100 Arg Tyr Asp Lys Val Asp Leu Glu Pro 150 Tyr Phe Ser 165 Ala Phe Glu 180 Tyr Ala Leu Val Ser Phe 55 Lys Gin Lys Lou Asn 135 Lys Lys Val Tyr Phe 40 Ala Ile Ile Ser Lys 120 Leou Asp Arg Leu Ser 25 Asn Phe Arg Leu Asp 105 Ala Phe His Leu Thr 185 Tyr 10 Ile Leu Phe Leu Ser 90 Leu Asp Lys Ala Lys 170 Asn Leu Asp Pro Ser Tyr 75 Gin Ala Leu His Lys 155 Ala Ala Pro Ile Trp His Asp Lys Asn Tyr 140 His Phe Gin Gin Ala Val Glu Thr Asn Thr 125 His Ser Ile Ile Ala Val Phe Lys Gin Leu 110 Pro Asn Leou His Pro 190 Thr Phe Leu Phe Ile Tyr Ala Trp Leu Leu Phe Lys Asp Lys Thr Ser Gin Asn Ser Ile Glu Ala Tyr 160 Asn Asp 175 Leu Glu Leu Lys Asn Leu Arg Arg 195 INFORMATION FOR SEQ ID NO:1828: SEQUENCE CHARACTERISTICS: LENGTH: 458 amino acids TYPE: amino acid TOPOLOGY: linear 'T Afnr 4Mfinfnim.
POUS 96/O91 2.
h:J1iU- ~u 199 1354 (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .458 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:i828 .vn Giv Lou Lau Leu Ser Val Ala Leu Pro Asn Sen Asn Asn Gin1 1 Ala S Lys bo.
Gin P Glu Met C His Ala I LauC Ser2 145 Leu Phe1 Gin Tyr Gly 225 His Lou Asn Gin Gly 305 Val Met Asn LSp ler aet l.a ;lu er er ;iu 130 3iu 3iy Giy 210 Gly Sen Lys Ala Arg 290C Gli Gil
I
Gin Sen Tyr Val1 Thr Lou Lou 115 Met Phe Lou Lys Val 195 Lou Tyr Lou Arg Sor 27S Asj ~'Lei i As: .1 Se: 5 Asn Asn Tyr Gly Ile Val C Gly Gly Lys Glu Asn Glu 100 Ile Ser Ala Ser Arg Ala Lys Asn 165 Tyr Ser 180 Gly Gly Asn Val Val. Ala Ala Asn 245 Asn Glu 260 His Ile Asn Tyr SPh. Met i Sen Tyr 325 i Pro Ala 340 r Val Lou le ~sn fly ksn 0o ksn Ie ksn Tyr Ping 150 Ljys Gin Ala G ly Tyr 230 Asn Phe Asn Asn Phe 310C Lou I Lys IleC 55 Asn Pro Leu Pro Thr 135 Giu Arg Lou Sen Tyr 215 Gly Val.
Thr Sen *Thr 295 Lys er fai I0 ;ln Lou 3iy PAsn 120 3 ly Ph.
Ser Ph.
200 Asp Tyr Asp Lou Ser 280 Trp Gir 10 Lou Ser 25 Met Asp Gly Gin Ile Lys Phe Ala 90 Val Thr 105 Ph. Arg Gin Thr Glu Ser Ser Asp 170 Lys His 185 Ile Sen Ang Lou Ser Gly Val. Gly 250 Ser Ala 265 Asn Ser Thr Thr Lys Sen lai Ph.
Sen rrp 75 Pro Lys An Ser An 155 Pro Pro Gly Val Lou Thr Ala Lou Ile Asp Asn Ang 140 Ph.
An Asn Gly Lys His Pro Lou Ser Tyr Lou Ala 125 Lau Ser Pro Asn An 205 Ser Gly Ala LThi Sol 28' L Asi 1 Loa Aqn C Pro Asn C Thr Lau Gin 110 Thn Thr Giu Ser Leu 190 Gly Val An Arg Tyr 270 *Val l, Gly .A Lys ;in 'hr ;ln iOu flu k.sn Sen Lys Arg Giu 175 Trp Thr Ile Ile Ala 255 Gly Lou Asn Prc Ile Lou Ile Met.
An Thr Lou Lou Lou 160 Val Ile Lou Lou Met 240 Ph.
Gly An iTyr Gin 320 220 Ph.
235 Met Asn Lou Ser Val Tyr Glu Let Va) Va: 315 His Ph. Ile Gly Lou Ser Gly Met Lys 330 Tyr Gin Gin Phe Val Met His 345 Thr Lou Asn Met Gly Lou Giu 360 355 Phe Lou 385 An Gly 370 Lou Thr Lys Ile Lou An Lys Lau Ser Tyr Ala Lys 390 Tyr Ang 405 Tyr 375 Giy Lys Ph.
Asp Gly Asn Glu Thr Ala Val Val 395 Ile Ph.
410 380 Ang Asn Sen 365 Lou Ph.
Thr 350 Ang Gly Val Ph.
Gly 335 Pro Lys Arg Asp Gly Giu 400 Ala Ser 415 Sen Tyr A iCgfnrM OUECT PcGT/I 96/091z IPEA/US 18 DEC1996 1355 Gly Giu Met His Leu Trp Arg Leu Met Tyr Val Asn 425 430 Leu Lys Met Gly Leu Gin Tyr Gin Asp Leu Asn Ile 440 445 Gly Met Arg Val Ala Phe 455 Val Ala Thr Ile Thr Gly 420 Gly Val Gly 435 Gly Asn Val 450 INFORMATION FOR SEQ ID NO:1829: SEQUENCE CHARACTERISTICS: LENGTH: 251 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...251 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1829 Thr Ile Leu 1 Gly Met Ser Ile Arg Phe Gly Met Asp Ala Gin Asn Gly Pro Phe Val Lys Asn Val Val Arg 115 Thr Gly Glu 130 Gin Leu Glu 145 Ile Ala Asn Pro Leu Val Ile Lys Val 195 Pro Pro Thr 210 Asp Leu Lys 225 Cys His Thr Phe Asn Lys Gin 100 Thr Ile Lys Trp Arg 180 Ile Ile Lys Pro Gly Ala 5 Ile Leu Leu Lys Phe Asp Ile Met Leu Leou 165 Leu Tyr Trp Ala Asn 245 lie Asn Ser Lys 70 Phe Tyr His Leu His 150 Ser Ala Glu Gly Lys 230 Lys Gly le 55 Asp Leu Trp Asn Met 135 Asn Leu Ile Gly Tyr 215 Glu Lys Ser Pro 40 Leu Glu Trp Gly Phe 120 Thr I1e Asn Asn Phe 200 Asn Leu Ser Tyr Lys 10 Ile Glu Ala I 25 Glu Ala Pro I Ser Lys Asp Leu Ala Lys 75 Asn Lys Asp 90 Leu Lys Ala 105 Ser Thr Arg Gly His Asn Val Val Asp 155 Thr Gin Lys 170 His Ala Ile 185 Ala Gln Lys Tyr Asn Ile Leu Lys Gin 235 Ser Leu Leu 250 ryr Leu ?he ryr Lys Glu Tyr Ala Leu 140 Arg Lys Asn Met Lys 220 Trp Asp Leu Ala Pro Lys Leu Leu 125 Asn Ser Tyr Val Val 205 Pro Glu Asp Ala Asp Val Ile Asp 110 Ala Glu Pro Phe Asp 190 SAsn iTyr Gly Tyr Asn Tyr Gly Ile Lys Leu Val Gly Asn 175 Asp Pro G1u Met Thr Leu Leu Thr Leu Val Arg Glu Leu 160 Asn Tyr Phe iTyr Asn 240 Ala Gly Tyr Prc Gly Phe Lys Thr Ile Cys Thr INFORMATION FOR SEQ ID NO:1830: SEQUENCE CHARACTERISTICS: KL37 AMEN'DEO SHEET PCT/US 96/091 2.
IPEA/US 18 0EC1996 1356 LENGTH: 879 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...879 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1830 Ile His Ile 1 Pro Leu Asn Leu Asp Leu His Tyr Ile Ala Asn Asn Gly Ile Lys Ala 130 Leu Ile 145 Ile Ala Asn Thr Arg Pro Leu Asn 210 Gly Gin 225 Thr Thr Met Asp Pro Ser Thr Asn 290 Gly Ser 305 Gin Glu Ala Tyr Asn Trp Leu Asp 370 Phe Phe Ile Gin Ser Gin Asp 115 Leu Gin Asn Ser Pro 195 Ala Asp Asn Ala Asp 275 Asp Ser Ser Gly Gly 355 Phe Lys Leu Trp Met Asn Gly Asn 100 Val Gin Ser Asp Ile 180 Ile Leu Leu Ile Leu 260 Thr Pro Phe Ala Asn 340 Gin His Arg Ile Phe 5 His Asn Arg Ala Leu Leu Ala Glu Ala Leu 165 Gly Asp Ile Phe Lys 245 G1u Leu Lys Lys Thr 325 Thr Ile Ile Thr Val Leu 70 Lys Lys Gin Phe Asn 150 Glu Gly Ser Ser Leu 230 Leu His Arg Glu Glu 310 Lys Ser Glu Ala Phe Thr 55 Gin Ile Phe Asn Ser 135 Asp Arg Glu Asn Ser 215 Gly Leu Ser Glu Phe 295 Lys Val Gin Ile Leu Pro Ser 40 Phe Asn Arg Gin Ala 120 Lys Val Leu Phe Gly 200 Asp Thr Asn Ser Leu 280 Phe Phe Ser Asn Lys 360 Leu Lys 10 Leu Lys 25 Leu Phe Gly Ser Lys Ile Tyr Gly 90 Tyr Glu 105 Tyr Thr Thr Met His Ser Lys Glu 170 Leu Phe 185 Lys Tyr Asn Leu Asp Lys Gin Asn 250 Leu Pro 265 Ile Gly Tyr Leu Ala Leu Asp Leu 330 Lys Val 345 Asn Leu Asn Thr Pro Pro Phe Met Val Lys Lys Lys Tyr Asn Asn Asp Ala 75 Tyr Gln Asn Glu Asn Thr Ser Thr Leu 125 Glu Ala Phe 140 Glu Thr Ser 155 His Met Ile Gly Gly Ser His Gly Asn 205 Val Pro Tyr 220 Asp Lys His 235 Lys Leu His Glu Glu Val Phe Ile Thr Gin Asn Ser Leu 110 Asn Lys Arg Asn Lys 190 Gly Asn Lys Pro Phe 270 Lys Arg Tyr Ile Ser 350 Ser Asn Ile Asn Met Thr Asp Asp Thr Thr Ala Val 175 Val Glu Ile Leu Asp 255 Ile Asn Pro Gin Gly 335 Leu Glu Pro Ile Lys Asn G1n Ire G1n Asp Lys Ala 160 Ala Asp Asp Ser Ile 240 Val Lys Pro Asp Asn 320 His Asn Asn Asp Gin Asp 315 Leu Val Thr Asn Gly 300 Lys Asp Asp Pro Asp 285 Ile Ala Lys Val Gly 365 7- '1 4 Leu Ile Ser Ser Asp Gly Asp Phe Asp Asp Leu Asp 375 380 A «-4cA'n?!n ?ucc PCT/US 9 6 /0912 IPEAIUS 18 DEG 1996 1357 Ala L 385 Phe V Tyr Asn Lys Ala 465 Leu I Glu 2 Leu 2 Leu I Asn 2 545 Lys I Gly Val Gin Val 625 Lys Ala Asp Lys Val 705 Lou Asp Lys Val Ser 785 His Gly Gin Thr Ala 865
RAL
(2)
TO
eu al Asn Val Val 450 le Asp Arg Arg Ser 530 Asn Leu Ser ?he Ile 610 Lys Pro Leu Asn Gln 690 Ile Phe Lys Pro Arg 770 Asp Lou Lys Val Ty? Se Arg S Thr I Pro .4 Leu 435 Glu Lys Val Phe Ile 515 Thr Ala Glu Thr Asn 595 Asn Ile Asn Asn Pro 675 Ala Ile Asp Pro Ser 755 Lys Met Ser Ala Gin 835 Asn r Thr er Asp Lys 420 Ala Thr Ile .ys Asn 500 Ile Leu Ser Ser Lys 580 Met Lou Pro Glu Tyr 660 Thr Lys Gin Lys Ser 740 Val Gly Arg Asp Phe 820 Sel Lys As Ser C Arg 405 Val I Asn Leu Pro 2 Asn 485 Asn C Asp Asp Glu Asn 565 Leu Lys Asp Lou Val 645 Ser Ser Asp.
Asp Asp 725 Lou Asn Ile Asn His 805 Giu Ile Phe n Lys ;ly 390 er I Leu C .ys .ys Asn 470 Ser Glu Asn Gln Tyr 550 Val Ser Lou Asn Tyr 630.
Thr Asn Lys Asn Asn 710 Ala Lys Phe Tyr Leu 790 Ile Asn Arg Ser Ile 870 .ys Leu lu Asn Ile 455 Leu Thr Val Ser 4 ys 535 Gln Ala Glu Asn Asn 615 Asp Tyr Thr Giu Lou 695 Met Asn Lou Phe Arg 775 Gly Gil Il Gi As 85 As Arg V Ser G Ile P 4 Thr I 440 Asn A Pro I IleL Asp V 5 Ser L 520 Gly L Lys Gin Val E Asp 1 600 Gly Pro Arg Asp Ser 680 Ser His Asp Asn.
Asp 760 Pro Ile Lys e Ile y Giu 840 n Leu 5 n Asa al 1n ro 25 ys la le 'ys Fal 05 eu Thr Thr Ser 585 Val la Thr Gln Pro 665 Lys Ile Ser Phe Ala 745 Gin Asp Gin Met Arg 825 Thr Thi Let Thr Val 410 Ser Leou Ser Asn Asp 490 Giu Giu Giu Tyr Ala 570 Lys Asn Phe Thr Leu 650 Ala Giu Asn Asn Ser 730 Asn Leu Ala Asn Ile 810 Glu 395 Lys Val Ser Arg Leu 475 Lou Ile Ser Val Phe 555 Gln Gly Gly Lou Ala 635 Met Ile Arg Lou Thr 715 Gin Asn Glu Lou Gly 795 Ala Tyr Ala Phe Glu Leu 460 Asp Lys Glu Pro Ala 540 Asn Asn Ser Ser Ser 620 Asp Asp Tyr Phe Asn 700 Lys Asn Ala Asn Gly 780 Ii0 Lys Val Val Val Ile 445 Gly Ile Asp Thr Ile 525 Gly Lys Asp Lou Phe 605 Lou Ile Ala Gin Ile 685 Glu Met Ala Leu Ile 765 Asp Thr Asr Lys Pro Thr 430 Phe Asp Pro Ala Asn 510 Ser Ile Glu Ala Glu 590 Lou Pro Gin Met Gin 670 Glu Glu Gin Lou Ile 750 11e Thr Let; Gly Ser Asn 415 Lys Gly Glu Ile Ile 495 Gly Phe Pro Gly Ala 575 Asn Glu Asn Ala Ser 655 Ile Leu, Gly Phe His 735 Ile Thr Tyr Ile Al9 815 Ala 400 Met Asp Asp Ser Leu 480 Lys Arg Ala Thr Ala 560 Asn Ser Ala Gly Ser 640 Ile Ser Leou Lys Met 720 Ser Asp Ser Ser Asp 800 His s Thr I Glu l Lou u
I
Arg Asn Glu Val Leu Ly 830 Thr Asn Ser Gly Asn Leu 875 Met Al Ala Va Tyr Le INFORMATION FOR SEQ ID NO:1831:
~WIIP~
PCI
iPE 1358 SEQUENCE
CHARACTERISTICS:
LENGTH: 181 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION 1...181 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1831 Ile Asp Gin Ile Lys Ile Met Lys Leu Val Ser Leu Ile r/u? 96 /0912 A/US 18 E C 1996 Val Ala Arc 1 Leu Gin Glu Ser Arg Glu Thr Thr Val Thr His Lys Ser Gin Tyr Ser Phe Gin Asn Ala Asp Ser His 115 Ser Val Met Tyr Cys Glu Gly Lys Lys Tyr 100 Val Tyr Arg Arg Ala 180 5 Cys Phe Lys Lys Gly 85 Lys Arg Asp Phe Leu Phe Asp 70 Val Gly Val Lys Leu Gly Ala 25 SVal a Val 31y Tyr Met Lys 40 Tyr Ala Tyr 55 Lys Leu Asn Val Phe Leu Gly Lys Ala 105 Thr Gin Asn 120 Trp Gly Tyr 135 Glu Ile Ser Ser Gly Pro Ser 90 Tyr Ser Val Ilie Glu Leu Pro Ser Phe Val 45 Ile Ser Asp 60 Asn Pro Lys 75 Asp Leu Ile Asn Phe Tyr Asn Gly Asp 125 Gly Asn Thr 140 Leu Lys Leu 155 Gly Glu Val Leu Lys Asp 110 Leu Phe Lys Val Phe Asp Arg Val 95 Gly Glu Thr Arg Tyr Phe Gly- Asn" Gly Lys Phe Leu Phe 160 130 Lys Arg 145 Asn Leu Lys Ala fGl a 150 Ser Phe Tyr Arg 165 Thr Gin Thr His Leu Phe Ser Ile Gly 170 175 INFORMATION FOR SEQ ID NO:1832: SEQUENCE CHARACTERISTICS: LENGTH: 215 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...215 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1832 PcriS 96/091Z2.
IPEAUS IS u EG1996 1359 Lys Asp Leu Sor Lys Met Phe Val Val Phe Ile Glu Gly Phe Gly Lou 1 .5 10 Ala Ile Ser Leu Cys Ala Ala Val Gly Ala Glri Ser Lou Phe Ile Val 25 Glu Arg Gly Met Ala Arg Asn Tyr Val Phe Leu Ile Cys Ala Leu Cys 40 Phe Met Cys Asp Ile Val Leu Met Ser Met Gly Val Phe Gly Val Cly so 55 Ala Tyr Phe Ala Lys Asn Leu Tyr Lou Ser Lou Ph. Leu Asn Lou Phe 70 75 Gly Ala Val Phe Thr Gly Ph. Tyr Ala Phe Lou Ala Leu Lys Thr Lou 90 Ph. Gin Thr Phe Lys Lys Lys Gin Val Gin Thr Pro Lys Lys Leu Ser 100 105 110 Leu Lys Lys Thr Lou Lou Ph. Thr Lou Gly Val Thr Lou Lou Asn Pro 115 120 125 Gin Val Tyr Lou Glu Met Val Phe Lou Ile Gly Ala Ser Ala Met Ser 130 135 140 Ph. Asn Lou Val Gin Lys Ph. Val Ph. Lou Ala Giy Thr Lou Ser Ala 145 150 155 160 Ala Pho Ser Trp Lou Lou Lou Lou Cys Thr Met Sor Lou Arg Tyr Gly 165 170 175 Ser Lys Lou Lou Asn Asn Gin Lys Ile Ph. Met Gly Val Asn Leu Ph.
180 185 190 Val Thr Ala Ile Met Gly Thr Lou Ser Vai Thr Lou Ph. Arg Asp Phe 195 200 205 Lou Ala Lou Lou Sor Lys Thr 210 215 INFORMATION FOR SEQ ID NO:1833: SEQUENCE
CHARACTERISTICS:
LENGTH: 240 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES.
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-.feature, LOCATION .240 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1833 Met Asp Ilie Lou Lys Ala Giu His Lou Asn Lys Gin Ile Lys Lys Thr 1 5 10 Lys Ile Val Ser Asp Val Ser Leu Giu Val Lys Sen Gly Gu Val Vai 25 Gly Lou Lou Gly Pro Asn Gly Ala Gly Lys Thr Thr Thr Phe Tyr Met 40 Ile Cys Gly Lou Lou Glu Pro Sen Gly Gly Sor Val Tyr Lou Asn Asp 55 Val Asp Lou Ala Lys Tyr Pro Lou His Lys Arg Ser Asn Lou Gly Ile 70 75 Gly Tyr Lou Pro Gin Giu 5cr Ser Ile Phe Lys Glu Lou Sor Val Glu 8S 90 Gu Asn Leu Ala Lou Ala Gly Giu Son Thr Phe Lys Asn Ser Lys Glu Y>l100 105 110 r -er Glu Giu Lys Met Glu Sen Leu Lou Asp Ala Ph. Asn Ile Gin Ala ArMl',IrM PWCCr POT/USOr 9b u 91a a 1 PAJS 180UU1996 1360 115 120 125 Ile Arg G1u Arg Lys Gly Met Ser Leu Ser Gly Gly Glu Arg Arg Arg 130 135 140 Val Glu Ilie Ala Arg Ala Lou Met Lys Asn Pro Lys Phe Val Leu Leu 145 150. 155 160 Asp Glu Pro Ph. Ala Gly Val Asp Pro Ile Ala Val Ile Asp Ile Gin 165 170 175 Arg Ile Ile Glu Ser Lou Ile Gly Lou Asn Ile Gly Val Lou Ile Thr 180 18S 190 Asp His Asn Val Arg Glu Thr Lou Sor Val Cys His Arg Ala Tyr Val 195 1200 205 Ile Lys Ser Gly Thr Lou Leu Ala Sor Gly Asn Ala Asn Giu Ile Tyr 210 215 220 Glu Asn Ala Leu Val Arg Lys Tyr Tyr Leu Gly Giu Asn Ph. Lys Val 225 230 235 240 INFORMATION FOR SEQ ID NO:18 34 SEQUENCE
CHARACTERISTICS:
LENGTH: 80 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL
SOURCE:
ORGANISM: HelicObacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1834 Asn Thr Gly Lou Trp His Son Trp Gly Lou Ala Pro Ala Lou Lou Giu 1 5 10 1s Thr Gin Lou Pro Lys His Ala His Gin Ph. Ph. Gin Ile Ph. Ph. Ph.
25 Pro Lys Lys Pro Ph. Lys Gin Met Ile Val Ile Val Giu Lou Lou Val 40 Asn Pho Ii. Ph. Asn Lou Ph. His Ala Ile His Val Gly Val Lys Mot 55 Ile Asp Asn Ile Lys Lou Pro Lou Ang Arg Ile Lys Met Arg Ala Lou 70 75 INFORM4ATION FOR SEQ ID NO:183S: SEQUENCE
CHARACTERISTICS:
LENGTH: 548 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: rN(A) NAME/KEY: misc..featunO XR -'MSHEET POT/US 96/0912.2 IPEANS 18IJEC 1996- 1.361.
LOCATION .548 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:i835 Ile Asp LeU Gly Val Ile Gilu Thr Ile Pro Lys His Ser Lys in Leu Asp Ile Lys Asn Gin Asn Asn Pro 145 Val Arg Vali Giy Leu Pro Pro Ser Thr Thr Asn Met Ala 130 Ser Asp Lys Giy Val 210 Lys Gly Tyr Asp Asn Cys Phe Ile 115 Pro Lys Gin Lys Leu 195 Giu Thr iu l'hr Thr Leu Pro Thr 100 Ala Phe Cys Gin Ile 180 Ala Aia Ilie Aia Phe Asp Ph. Phe Phe Asn Thr Gin 55 Ile Met Lys 70 Tyr Asn Asn 85 Pro Gin Thr Val Lou Asp Giu Phe Thr 135 Val Asn Pro 150 Tyr Ile Leu 165 Giu Ile Asp Asn Gly Tyr Tyr Aia Lou 21.5 Ser Lou 25 Pro Lys 40 Arg Val Tyr Ser Asn Giy Aia Giu i0s Ser Gin 120 Asn Ser Gly Vai Asn Lys Ala Val 185 Gly Asn 200 Asp Pro Lys Glu Ala Phe Asp Vai Ile Phe Giu Ala Thr Ser Thr Ser Le4 An5s Ph.
Asn Asn 90 Giu Ser Ser Asfl Gin 170 Val1 Giu Giu 75 Thr Phe Trp Thr Gly 1.55 Gly Lou Thr 60 Asn
LYS.
Thr Gly Asp 2.40 Arg Ile LY4 Pro Asn Asn Asp 2.25 Cys Val Ile Asn Asn Asp Lou Ala Asp Asp Asn Ser Asn Cys Met Ile Ser Thr Asn 175 Gly Ile Phe Trp Lou Lou Asp Lys 160 Phe Val1 Asp Gly Giu Lys Lys Lou 220 Asn Lou Giu Asp Lou Arg Ser H Vai P Pro L Gly P 2 His A 305 Val IJ Asn Gin Thr Arg 385 Ph.
Tyr Giy Ser Ile 465 Lys is ro ye 'he .90 Lsr ~rp 37(C Se2 Asi Al Ii.
Pr Ph Va Thr L,.
Val T 2 Asp S 275 Asn G Cys Gin C Gly *Lou 355 Ser Pro iAsp Lys e Asp 435 o Thr 0 e Gly 1 Lys 's G 2 hr L 60 or A in P la ;in I ;or 340 kla Ile Ph.
Ala 420 Lou Gly Gly Gly ly 45 ys .sp ro .ou 12S kr Le~ I i Va Le I1 Le Se 230 Tyr Gly His A~ Asp Gly Gin V, 2 Gly Lou ProT 280 Ala Ph. Pro S 295 Val Pro Ala G 310 Ile Msn Gin P, Thr Asn Tyr 2 Ser Met Lou 360 Asn His His 375 x Gly Val Asn 390 e Gly Lou Ala 5 2. Asn Gin Lys u Lou Asp Ph.
440 e Gin Thr Lys 455 u Arg Gly Leu 470 ~r Gly Asn Lou sn G 2' 1i G 651 yr A or A ly P sen 145 ;er Ph.
Ala Tyr Val 42S Ile Arg Tyr Asp 50 iu en sn 'ho lia 130 rh2 Se: Ly
TY
41.
Gi Tli As 235 Asn M Lye A Val C Tyr P 3 Lou G 32.5 Lou I Msn c Ile r Msn 9 Ile 395 rGly 0 n Gin *r Thr *n Ph.
5n Ser 475 ii Ala et y5 ro 00 *ro 38 Ii Le Se T1 190 1 Tyr Gly Thr Lou, 205 Ph. Giy Asn Asp Lou His Giu Ph.
240 Thr Tyr Gin Arg 255 Sor Asn Gly Lye 270 Ser Lou Tyr Gly 285 Asn Ser I1e TYr Val Thr Ala Ala 320 Ile Asn Tyr Ala 335 L Ser Lou Asn Thr 350 1 Lys Thr Ph. Val 365 a Ser Gin Ser Ph.
0 Y Tyr Gin Asn Tyr 400 e Ile Lys Tyr Asn 41S u Ser Tyr Gly GlY 430 ~r Ser Asn Lys Asn 445 rr Ser Ser Phe Gly ~r Tyr Val Lou Asn 480 ir Gly Lou Asn Tyr PuillJs 96IO0-i22.
IPENUS A1DEC 1996 1362 Arg Gin Phe Gly 545 485 490 495 Lys His Ser Lys Tyr Ser Val Gly Ile Ser Ile Pro Leu Ile 500 505 510 Lys Ala Ser Val Val Ser Ser Gly Gly Asp Tyr Thr Asn Ser 515 520 525 Phe Asn Giu Gly Ala Ser His Phe Lys Val Phe Phe Asn Tyr 535 540 Val Phe INFORMATION FOR SEQ ID NO:1836: SEQUENCE CHARACTERISTICS: LENGTH: 420 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Holicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1 .420 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1836 Asp His 1 Ala Ala Pho Leu Gin Ala Ala Met Asp Leu Giu Arg Gin Gin Gin Asp 130 Lou Son 145 His Ph.
Pro Asn Leu His Asp Leu 210 Arg Trp 225 Thr Leu AaCys
BA/O,-
Ser Ph. Asn Ilie Gin Asn Ser Ile His Arg Cys Ile Asp Lou Thr 115 Ciii His Tyr Met Asn 195 Lys Sor Cys Lys Pro Arg Pro Ala Lou Val 100 His Ii0 Arg Ala Tyr 180 Asn Lys Gin Val1 Ser 260 Ile Val1 Lou Tyr Asp Lou Ser Sor Pro Ser 165 Gly Asp Lou Thr Ala 245 Met Lys Ph.
Giu Lou 70 Lou Thr Lys Ala Gin 150
LYS
Val His Val Pro 230 Ile Arg Pro Val Ph.
Lou Lou Asp Giu Tyr 135 Ile Trp Lys Lou Ser 215 Arg Met Ile Ile Gly 40 Val Ala Ile Ile Lou 120 Ph.
Lou Giu Glu Phe 200 Met Val1 Gly Asn Lys 25 Ala Clii Lys Lys Lys 105 Ala Ser Ciii Ph.
Ile 185 Ciii Ph.
Pro Tyr His 265 Ala Ser Lou Asp Tyr 90 Pro Ser Lou Thr Asp 170 Lys Cly Cly Gin Lou 250 Ph.
Lys Pro Ile Asp Lou 75 Ph.
Pro Tyr Clii Gin 155 Ile Asp Lou Gin Thr 235 Lou Lou Arg Lys Arg Lys Lys Cys Ile Val Glu 140 Ile Ile Lys Ph.
Lou 220 Ser Ser Cly Lys Lou Ang Gin Asp Ph.
Ph.
Ala 125 Lou Lou Tyr Ile Gly 205 Arg Val1 Phe Gi) Val1 Lys Trp Ala Arg Clii Tyr 110 Gin Lys Ciii His Asp 190 lii *Ph.
*Lou Asp Lou 270 Met Sen Asn His Gly Ph.
Ala Son Ciii Ser Ph.
175 Lys
LYS
Gin Cly Lou 255 Ph.
Tyr Gln Asp Lys Lys Lou Lou Lou Tyr Ala 160 Asn Gin Clii Lys His 240 Lys His PCT/US 96/09122, IPEAUS 18 DEC 1996 1363 Asp Ser Met 305 Leu Ser Tyr Cys Gly 385 Leu Arg Leu Val 290 Gin Lys His Asn Asp 370 Ile Arg Asp Pro 275 Ala Asn Tyr Gin Ser 355 His Ser Ser Phe Glu Gly Lys Phe Ile 340 Asp Leu Ser Gin Lys 420 Ile Leu Val Thr 325 Val Glu Ser Tyr Thr 405 Ile Lys Ser Lys 330 Ala Cys Ala Gly Leu 410 Ile Glu Leu 315 Asn Glu Gly Gin Ala 395 Asp Pro 285 Glu Val Tyr Leu Leu 365 Ser Asn Gly Ile Lys Gin Lys Phe 350 Leu Leu Leu Lys Lys Lys Glu Asp 335 Thr Lys Ser Leu Leu 415 Gin Glu Asp 320 Lys Leu Val His Glu 400 Phe INFORMATION FOR SEQ ID NO:1837: SEQUENCE CHARACTERISTICS: LENGTH: 268 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...268 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1837 Asn 1 Asp Leu Lys Lys Lys Glu Asp Val Ile 145 Lys Ile Phe Val Leu lie Glu Ile Lys Ala 130 Gin Met Thr Ile Lys 5 Ala Trp Lys Gly Cys Ser Asn Tyr His Leu Leu Leu Tyr Glu Asn Leu Gin Asn 100 Asp Asp Phe 115 Met Asn Gly Lys Lys Ser Glu Arg Val Asp Arg Thr Met Lys Pro Pro Arg 70 Lys Gin Ser Glu Glu 150 Cys His Ala 55 Pro Phe Gly Phe Ile 135 Pro Phe Ile 40 Ser Ala Lys Tyr Ala 120 Val Gly Pro Leu 25 Ile Glu Phe Asn Lys 105 Gin Leu Leu Ala Lys 10 Gly Glu Lys Gin Gin 90 Val Lys Arg Leu Gly 170 Ala Thr Val Tyr 75 Thr Ile Lys Pro Phe 155 Phe rhr Asn Gly His Phe Lys.
Ser Asn Gin Ser Thr Asn Glu Asp 140 Ser Val Val Glu Ala Asp Leu Val Gly 125 Pro Thr Lys Val Val Leu Asn Lys Asp 110 Tyr Lys Gly Val Ala Leu Ala Leu Asp Glu Ile Ala Val Glu Ser Ser Leu Ala Arg Thr Leu Asp 160 Thr Ile 175 Asp Leu Leu Ile 165 Lys Pro Met Ser Gly Glu Ser Leu Asp Ser Phe Thr Met Pu 6 091.2.
I PEA/Uo 18 0EC 1996 1364 180 185 190 Ser Giu Leu Asp Ile Gin Glu Lys Phe Leu Lys Thr Thr His Ser Ser 195 200 205 His Ser Gly Gly Leu Val Ser Thr Met Val Lys Gly Thr Asp Asn Ser 210 215 220 Asn Asp Ala Ile Lys Ser Ala Leu Asn Lys Ile Phe Ala Ser Ile Met 225 230 235 240 Gin Glu Met Asp Lys Lys Leu Thr Gin Arg Asn Leu Glu Ser Tyr Gin 245 250 255 Lys Asp Ala Lys Glu Leu Lys Asn Lys Arg Asn Arg 260 265 INFORMATION FOR SEQ ID NO:1838: SEQUENCE CHARACTERISTICS: LENGTH: 100 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...100 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1838 Ser Asn Phe Lys Lys Gly Phe Phe Met Phe Lys Ser Arg Leu Asn Ser 1 5 10 Trp Ile Leu Leu Gly Ile Leu Gly Val Leu Val Val Val Phe Trp Asp 25 Val Ile Lys Tyr Lys Ile Glu Asp Leu Gin His Asp His Tyr Leu Ser 40 Gin Val Lys Giu Arg Glu Glu Tyr Tyr Lys Asn His Ile Glu Glu Ala 55 Leu Lys Lys Asp Ser Glu Cys Phe Glu Lys Gly Gly Asp Lys Val Asp 70 75 Cys Ser Ala Ala Met Arg Ile Ala Ala Gly Glu Arg Asn Arg Arg Met 90 Leu Glu Ile Lys 100 INFORMATION FOR SEQ ID NO:1839: SEQUENCE CHARACTERISTICS: LENGTH: 242 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature PCT/US 96 091 2i2- WPEJVIJ$ t G 1996 1365 LOCATION .242 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1839 Lys Gin Asp Lys Lou Trp Lou Phe Leu Val Ile Ile Giu Lys Leu Gly Ile Leu 130 Lys Asn 145 Ser Lys Ala Tyr Arg Ile Ile Pro 210 Asp Asp 225 Ser Leu Lou Leu Ile Asn Ph.
Lys Ala 115 Asp Ala Val1 His Thr 195 Met Lou Gin Asp Ala Ala Aen Lys 100 Val Lou Lou His Trp 180 Thr Asn Ile Ph.
Tyr Ile Asp 70 Sor Ile Arg Arg Ilie 150 Ala Asn Phe Ser Ser 230 Lys Asp Thr Tyr Val Thr Lou Ile 135 Asn Lou Leu Ile Val 215 Ile Phe Asn Sor 40 Pro Cys Lou His Ile 120 Asn Asn Asn Lou Gly 200 Glu Gin Lys 10 Asp Ile 25 Lou Glu Lys Ile Lou Thr Thr Pro Ser Lou 105 Ph. Cys Ph. Lys Lys Lys Lou Leu 170 Lys Ile 185 Lou Lys Pro Sor Thr Thr Gin Ser Gin 75 Lou Ile Tyr Ser Asn Trp Gin Asp Lys Asp 235 Leu Lou Asn mot Ile Lou Lys 140 Pro Thr Prp Asn Ile 220 Arg Ile Lye Lou Lys Lys 5cr.
Lou 125 Tyr Lou Ile Asn Asp 205 Val Giu Lou Giu Giu Giy Giu Lys 110 Glu Pro Ser Arg Lys 190 .Arg Lou Ile So r Asn Ile Sor Lou Met Gly Asn Ser Asn 175 Arg Ala Ph.
Met Lys Lou Tyr Giu Lys Ser Val Asn Ala 160 Arg Pro Arg' Lou Ser 240 Gly Aen Lys Lou Glu Asp Lou INFORMATION FOR SEQ ID NO:i840: SEQUENCE CHARACTERISTICS: LENGTH: 467 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .467 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1840 Gly Met Lye Ala Lou Lye Thr Ph. Lou Lye Lye Son Lou Ile Lou Lou 1 5 10 Leu Ala Ile Ala Lou Asn His Leu Asn Ala Val Ala Met Ile Val Asp 2S Asn Pro Thr Gin Asn Ala Trp Asn Gly Aia Lye Ang Ala Trp Asp Glu 40 \Ver Lye Trp Ala Lye His Lou Ala Thr Ile Thr Giu Ang Ile Lye Lou P)/US 96/0912? IPEA/US 18 DEC 1996 1366 Ala Lys Ile Phe Gin Lys 145 Glu Asn Ile Leu lie 225 Tyr Gin Ser Thr Glu 305 Asn Asp Tyr Ala Met 385 Ile Glu Ala Ser Asn 465 Gin Val Leu Ala Asn 130 Cys Lys Thr Ser Glu 210 Gin Thr Ile Gin Phe 290 Asn Arg Ile Lys Gin 370 Gin Pro Gin Tyr Asn 450 Pro Asp Asn Ser Lys 115 Tyr Pro Asn Lys Thr 195 Tyr Leu Ala Ala Asp 275 Gly Arg Leu Ala His 355 Asn Ser Ala Lys Gly 435 Ser Tyr Thr Asp Ile 100 Gin Asp Glu Leu Ala 180 Ala Ile Leu Tyr Ser 260 Arg Phe Asn Lys Gly 340 Arg Leu Tyr Asp Gin 420 Ph* Asn Leu Val Pro Val Ile Leu His 165 Leu Asn Cys Asp Glu 245 Asn Ala Asn Gly Ala 325 Lys Phe Ser Ala Ala 405 Gin Pro Asn Asp 70 Leu Asn Gin Arg Asn 150 Gin Lys Asp Ile Ser 230 Lys Val Phe Asp Lys 310 Gin Lys Gin Phe Phe 390 Leu Glu Asn Glu 55 Arg Ala Asn Lys Pro Met Ala Asn 120 Asn Gin 135 Trp Asp Phe Phe Asp Phe Leu Gly 200 Gin Lys 215 Gln Met Leu Arg Tyr Ala Ser Gin 280 Glu Asn 295 Ser Glu Phe Asp Gly Glu Gin Leu 360 Met Asn 375 Lys Gin Lys Asp Ile Glu Gly Ser 440 Asn Thr Gin 105 Thr Ile Val Thr Ala 185 Ala Gly Thr Ala Lys 265 Met Val Cys Glu Ala 345 Ser Lys Gin Asp Lys 425 Val Gin Asn 90 Tyr Glu Ala Ser Ser 170 Asn Gly Asn Leu Glu 250 Val Asp Lys Ile Leu 330 Ala Val Thr Met Lys 410 Val Thr 75 Gin Val Arg Ala Gin 155 Lys Ala Leu Leu Ala 235 Lys Lys Asn Lys Pro 315 Asn Ala Glu Leu Gly 395 Glu Tyr Leu Asn Phe Leu Glu Lys Ile Lys 125 Lys Arg 140 Asp Ala Gly Lys Ile Gly Arg Gly 205 Glu Ala 220 Leu Leu Glu Glu Gin Leu Glu Leu 285 Gly Tyr 300 Asn Met Leu Asp Lys Val Thr Ala 365 Gly Leu 380 Tyr Phe His Gin Arg Ala Ser Thr Ile 110 Glu Ile Ser Glu Asn 190 Arg Ala Asn Leu Val 270 Gly Cys Leu Tyr Phe 350 Leu Met Glu Glu Lys 430 Ile Gly Gin Asn Ser Pro Ser 175 Thr Ala Lys Asn Lys 255 Val Val Lys Asn Ser 335 Asn Glu Val Asp Asa 415 Leu Asa Ser Ser Ala Glu Thr 160 Ala GIn Leu Lys Asp 240 Arg Ala Lye Lys Val 320 Arg Asp Ile Gin Ile 400 Leu Asp Gly Lys Ala Ser Gly Val Asa 445 Pro Ser Ser Asp Asn 460 Ile Gin Ser Phe INFORMATION FOR SEQ ID NO:1841: SEQUENCE CHARACTERISTICS: LENGTH: 424 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES I77 4/VIT 0 4 PCT/US 9 6 /091 1367 (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...424 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1841 Arg Leu Asn Asn Met Ala Ala Pro Leu Leu Ala Leu Pro Phe Leu Ser 1 5 10 is Asn Pro Leu Val Leu Gly Ala Leu Ala Val Ile Gly Val Gly Ala Tyr 25 Leu Tyr Pro Asn Lys Gin Asp Ser Leu Val Val Gin Ala Asp Gly Leu 40 Tyr Ser Glu Ile Leu Gly Phe Phe Ile Ser Phe Ser Ser Lys Ile Leu 55 Lys Gly Ile Gly Giu Pro Leu Ala Asn Val Ile Gin Pro Phe Gly Met 70 75 Val Leu Gly Met Leu Leu Ile Leu Leu Tyr Ser Phe Lys Arg Tyr Gin 90 Asn Asn Asp Leu Phe Glu Ile Lys Thr Phe Leu Met Leu Phe Val Phe 100 105 110 Val Gly Tyr Leu Ser Leu Tyr His Tyr Ala Phe Lys Ser Asp Gly Ser 115 120 125 Ser Ser Gly Asn Gly Arg Ser Ser Phe Ala Phe Gin Asn His Val Thr 130 135 140 Glu Ile Phe Asp Thr Pro Ala Asn Leu Leu Asn Ala Gly Ile Ser Asn 145 150 155 160 Val Val Lys Glu Tyr Gin Thr Asn Ser Ala Arg GIu His Lys Asn Ile 165 170 175 Asp Thr His His Ser Ile Thr Asn Ala Asn Ile Ser Phe His Val Arg 180 185 190 Gin Ile Leu Thr Ser Leu Asn Lys Leu Tyr Glu Asp Phe Lys Ile Asn 195 200 205 Asn Gly Leu Ser Leu Lys Thr Leu Ile Ala Ala Val Leu Leu Leu Val 210 215 220 Ile Leu Gly Leu Glu Leu Phe Leu Leu Phe Lys Val Phe Cys Tyr Val 225 230 235 240 Phe Met Thr Tyr Leu Glu Lys Ile Ile Tyr Leu Ser Leu Val Ile Phe 245 250 255 Met Leu Leu Leu Gly Phe Phe Gin Gin Thr Arg Gly Phe Leu Val Ser 260 265 270 Tyr Val Lys Lys Ile Ile Ser Leu Thr Phe Tyr Met Pro Leu Leu Leu 275 280 285 Leu Leu Val Leu Phe Asn Ser Phe Ala Leu Gin Tyr Ala Ile Lys Val 290 295 300 Gly Gly Ser Asn Glu Ile Val Ala Lys Phe Gly Ile Ile Val Ala Ile 305 310 315 320 Gly Ile Ser Leu Thr Phe Ile Gin Lys Val Pro Glu Met Ile Asn Ala 325 330 335 Ile Phe Gly Thr Gin Gly Gly Leu Thr Asp Ala Lys Ser Phe Ile Tyr 340 345 350 Gin Gly Val Gin Met Ala Ser Ala Gly Ala Gly Ala Ile Ala Gly Set 355 360 365 Leu Lys Ser Val Gly Arg Ser Ala Phe Gly Arg Thr Leu Glu Ala Tyr 370 375 380 Lys Asp Ala Lys Ser Thr Ile Asn Ser Thr Thr Ala Asn Met Arg Asp 385 390 395 400 Met Pro Gly His Pro Gly Val Arg Val Gly Val Glu Thr Ile Glu Leu 405 410 415 Pro Lys Ser His Arg Ala Ser Lys A4 420 ~~NT Ou POT/US 96/09122 PA'U l8 0 C 1996 1368 INFORMATION FOR SEQ ID NO:1842: SEQUENCE CHARACTERISTICS: LENGTH: 384 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...384 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1842 Lys 1 Arg Leu His Thr Ile Lys Lys Leu Leu 145 Met G1u Leu Gly Leu 225 Pro Asp Met Thr Gly 305 Lys Asn Asn Phe Asn Ile Ser Glu Thr Ser 130 Phe Gly Pro Asn Gly 210 Leu Asn Cys Leu Asn 290 Ile Glu Arg Arg Leu Gin Pro Leu Gly Asn 115 His Leu Gly Ile Leu 195 Ph.
Leu Thr Ala Glu 275 Leu Leu Leu Tyr Leu I 5 Leu Lys Ile Ile Ala Leu Lys Pro Pro Asn Ala Arg 100 Arg Trp His Ser His Asp Trp Ala 165 His Phe 180 Ser His Met Leu Lys Phe Leu Asn 245 Val Met 260 Thr Cys Lys Asn Tyr Leu Trp Leu 325 Lvs Arg Gly Arg Asn Ala Ile Leu Glu Pro Ser w v .1 His det Val Asn 70 Asp Asp Ser His Asn 150 Thr Lys Leu Pro Asp 230 His Ala Lys Leu Ile 310 Ser Ala Lys Thr 55 Asp Asn Val Glu Glu 135 Lys Ser Phe Val Leu 215 Gin Gin Phe Thr Asp 295 His Lys Ala His 40 G1n Ala Leu Lys Ala 120 Tyr Ile Lys Ala Arg 200 Tyr Gin Leu Arg Pro 280 Asp Asn Leu 3 Phe I 25 Gin Thr I Leu Leu Ile 105 Phe Ile Leu Ile Arg 185 Asn His Asn Gin Asn 265 Thr Ser Pro Glu Glu 345 10 Phe hr 5 ?ro 1 Ser Ser 90 Ser Ile Lys Leu Tyr 170 Lys Lys Glu Asn Pro 250 His Asp Leu Ser Asn 330 Val Ser Pro Ala 75 Ala Ala Leu Lys Phe 155 Gin Leu Pro Leu Pro 235 Ser Ser Trp Asn Asp 315 Ser Gly Leu Pro Tyr Tyr Phe His Ala Tyr Phe Asn Leu Leu Thr 125 Leu Gly 140 Val Val Phe Glu Ser Leu Leu Asn 205.
Ala Thr 220 Arg Glu Leu Thr Phe Lys Gin Lys 285 Leu Leu 300 Leu Ser *Asn Ser Phe I Ala Thr C Ser E Ser C Phe I 110 Lys C Asn I Gly Ser Ser 190 Thr Gin Leou Pro Asp 270 Pro Asn Leu Phe le Phe ;in Ser ;ly Asp ;lu ?ro Val Ala 175 Pro Thr Tyr Leu Phe 255 Ser Ile Leu Arg Lys 335 Val Thr Let Leu Thr Ser Glu Leu Ser 160 Leu Phe Asp Pro Arg 240 Lys Leu Ser Asn Arg 320 Thr Leu Lys Val Leu 340 Asp Lys Ala Asr Val Ser Tyr Pro Ser Tyr Ser 350 POUS 96/0912.2 ~PEIUS ID G 1996 1369 Leu Asn Pro His Phe Ile Asp Ile Val Tyr Thr Tyr Asn Arg Ser His 355 360 365 Ile Lys His Ile Arg Phe Asn Met Ala Tyr Leu Asn Ser Leu Leu Lys 370 375 380 INFORMATION FOR SEQ ID NO:1843: SEQUENCE CHARACTERISTICS: LENGTH: 185 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: CA) NAME/KEY: misc-feature LOCATION .185 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1843 Leu Phe Ser Ser Pro Ile Leu Phe Ph.
Leu 145 Leu Thr Val Leu Leu Leu Phe Leu Ph.
Ser Cys 130 Val1 Asp Leu Met Ph.
Ile Ph.
Sen Lou Ser Leu Sen Cys Lys Lys Phe Asn 100 Ile Tyr 115 Ser Ser Ala Lou Ser Lou Tyr Lou 180 Ile Sen Sen Ser Tyr Thr Leu Phe Phe Ile Ser Asn Giu Leu Leu 70 Pro Pro Lou Lou His His Lou Phe Sen Ser 150 Lou Asp 165 Ala Lys Phe Val1 Ph.
55 Ile Lou Lou Ph.
Lou 135 Ser Ph.
Lys Ile 40 Leu Lou Giu Lou Met 120 Ser Lou Pro Asn 25 Leu Ser Ala Thr Thr 105 Ala Ser Leu Lou.
Lys Ser Ser Tyr Lou 90 Asp Sor Pro Met Ph.
Pro Asn Ph.
Ala 75 Gin Ile Lou.
Lou Arg 155 Lou Ser Lou Ile Thr Sen Ser Lou Ile Lou 140 Sen Phe Ph. Val Gly Lou Ala Lou Ala Pro Ph. Ser Tyr Ser Gly Ph.
110 Ph. Son 125 Gly Val Asn Ph.
Val Ph.
Trp Ang Lys Lou Cys Val Lou, Ala Ile Gln Phe 175S Leu Phe4 Asp Ser His Met Pro Lou Ala Ile 160 Lys Lys Ang Lou 185 INFORMATION FOR SEQ ID NO:1844: Ci) SEQUENCE CHARACTERISTICS: LENGTH: 982 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori NR0 1 A P. VC R I PN r r% C Ur "-r POT/US 9 6 /0912 IPE S 1 8 DEC1996 1370 (ix) FEATURE: NAME/KEY: miscfeature LOCATION 1..982 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1844 Lys A 1 Asn V His L Lys L Leu 0 Thr L Gly I Ile L Tyr G 1 Asp L 145 Lys Met I Ile Asn Arg 225 Phe Pro Thr Lys Gin 305 Ala Lys Ala Ala Phe 385 Tyr rg Ile Leu Met Lys Lys Arg Lys His Val Ser Lys Lys Val Phe al ys eu 0 lu ys le eu lu 30 ys Val Ala Tyr Thr 210 31n Ala Ser Leu Met 290 Prc Th Th Ty7 As 37 Se As Ile I 2 Thr L Gly I Val G Lys A Trp A 1 Asp P 115 Leu C Asn Gin N Phe Leu 195 Ser Ser Ser Glu Ile 275 Asp Gin r Phe r Thr r Lys 355 p Leu 0 r Val n Ile le 0 eu le lu rg la 00 sp iu Ile Val Asn 180 Gin Pro Gin Phe Phe 260 Lys Lys Lys So Pr 34 Va Ly Gi Pr Leu Ser Ser Arg Leu Val Lys Phe Lys Asp 165 Leu Gly Met Lys Lys 245 Ile Pro Thi Ili rAs 32 o As 0 1 Va s Le n Gi o Le Phe V Asn G Glu L 5 Val A Glu V Ser T Asn L Pro G 1 Leu L 150 Gly A Ile V Leu T Lys Asn 1 230 Ile Pro Ser Glu Thr 310 i Leou 5 t Tyr 1 Leu u Thr y Ser 390 u Tyr al ly eu 5 sp al yr ys ly 35 ys sn al hr er 15 Leu Asp Ser Val Let 29 Tyl Le Tyl Pr Le 37 Va Th Ala V 2 Ile H 40 Tyr L Leu S Ser A Phe G 1 Ala A 120 IleL Ile I Ala. F Lys I Asp 200 Leu Lys Asn Leu Val 280 Ile 5 li i Glu r Gly o Leu 360 u Gin s 1 Asn r Gin al P 5 is I eu er sp 1u 05 sn ,ys le is Pro Leu Ala Thr Ala Leu 265 Phe Phe Thr Ala Asp 345 he le C Lys Ser Leu Lys Ile Gly Asn Tyr 170 Leu Lys Phe Trp Leu 250 Glu Asn Lys Met Pro 330 Ser Ihr Gin Leu Phe Ile Leu Phe G1u Leu Ser Val Thr Leu Ile 235 Ile Asn Asp Asr Giu 31 Ly I1 Leu I Asn 1 Asn 1 Phe Lys Lys Phe Phe 140 Leu Pro Glu Ile Lys 220 Phe Lys Ser Gly Lys 300 Leu 5 Lo s Leu e Lys .eu V 3 eu L 45 Asn L fis G Asn I lal L 1
~S
AspG 125 Ser Phe Lys Pro Glu 205 Pro Asp Ala Val Leou 285 Gin Thr Glu Asp al 0 ys lys 1n le ys ly Leu Lys Ala Ser 190 Leu Leu Lys Asn Val 270 Ser Le Gi Va Le 35 Val I Ile G Leu S Lys P 8 Arg T 95 Glu I Asn Giu Asp Arg 175 Ala Lys Phe Ile Phe 255 Lys Pro i Leu y Ser 1 Phe 335 u Leu 0 le ly er ro i0 yr Ile Lys Asp lal 160 LyS Ala Ii.
Gin Gin 240 Thr Ala Iie Ile Tyr 320 Leu Ser Asp Phe Leu Ser Ile Lys Leu Gin Ala 410 Asp Ile Lys Glu 395 Gin Thr Ser Asn 380 Gly Ile Ile Met 365 Thr Thr Asn His Pro Ala Phe Leu Thr 430 Ser Pro Ser Asp 415 Arg Gly Asn ser Leu Leu 400 Ile Tyr Gin Thr Ala Gin Glu Ala Asn Met 435 Lys Asn Leu 450 Tyr Gin Tyr Ile Tyr 420 Leu Asp Leu Asp Ala 440 Ser Leu Asp Ser Leu 455 42S Lys Ile Ala Leu Asp Leu 445 Val His Lys Ile Gin Val 460 N Z Arrn!nrn 44141:FT POT/US 96/09122 IPEAUS 18 DEC 1996 1371 Asn 465 Asp Ile Thr Ala Asn 545 Giu Ile Ser Lys Phe 625 Val Lys A.sn Asn Ilie Asn Met Arg Ser Tyr ASP Pro 475 Pro Gin Thr Asn Phe Thr Leu Gin Ile Thr 530 Pro Phe Lys Leu Asp 610 Asp Tyr Asp Giu Lys Gly Asp Lys Pro Glu 595 Leu Ser Thr Ile Gly 500 Ala Asp His Asp Tyr 580 Vali Lys Phe Pro Thr 485 Giu Gin Thr Ile Asn 565 Ser Ser Ile Ser Ser 645 Lau Asn Ser Leu Gin 550 Ala Pro Thr Asn Leu 630 Lys Asn Ser Glu Lys 535 Trp Tyr Ile Ser Leu 615 Phe Ser Asn Ile Giu 695 Ly..
Glu Asp 520 Ser Ser Thr Met Asp 600 Pro Gly Ile Ile Ala 680 Ile Ala Asp Val 505 Lys Leu Val Phe Asp 585 Phe Ile Ser Ser Asp 665 Gly Gir Hi Leu 490 Phe Phe Ser Pro Lys 570 Tyr Val Tyr Ile Ile 650 Leu Leu Asp s Lys Lys Arg rhr Leu Gln 555 Ile Ile Asn Arg Asn 635 Lys Ser Phe Gil Il Asn Ser Arg Lys Ser 540 Leu Lys Ala Ile Ser 620 Lys Val Ile Ser u Asp 700 5 Asn LeU Lys Asp 525 Phe Leu Asp Leu Asp 605 Asp Asp Lys Asp Thr Gin Glu 480 His Ser Ile 495 Ile Ile Asp 510 Val Phe Tyr Asp Phe Ser Leu Glu Gly 560 Lou Lys Lys 575 Lys Asp Gly 590 Phe Phe Ala Gly Ser His Glu Ile Ser 640 Gly Asp Gin 655 Asp Phe Leu 670 660 Asp Ser Giu Lys 690 Ala Lys 705 Arg Ile Pro Leu Asp Gly Ala Leu 770 Ile Leu 785 Ala Leu Ser Lou Thr I14 Gly Tyi Tyr Lei 865 Aia Gi.
Lou Gl Pro Il Asn Va 93 Lou Al 945 Phe T1 Ser L) Lys 675 Pro Gin Met Pro Ala Ser Ser Lys Arg Tyr G11, 7 1C Lys 685 Val.
Pro G1 Ph
I
His Ala L) 7: Giu Asn L 740 Asn Tyr L' 755 Tyr Lou L Gin Lys A Giu Asp G 8 Lys Asn P 820 Pro Ser I 835 Gile I 0 Gly Lou y Asn Gly a Val Ser 900 o Val GlY 915 i Asn Val 0 ,a Ser Asp irPro Ile ys Arg Lys ys in 25 eu Lys Il he Ly Il As 96 Le Asp V Asp I Asn A Ala H 7 Phe V 790 Val P Ala I Ile Thr Lys 870 e Ile 5 1e r Ile r Lou s Gly e Ile 950 5 ii Lys al V le V la M 7 is A 7 5 al G he P eu b Val Gly 855 Ile Giu Lys Val Thr 935 Gin Ile al L al A 7 et I 60 sn P iu G sn C Met C ?he 840 Ser Asp Lou Ala Leu 920 Leu Ala Val eu la 45 he ly ly Gn A g Val Le As Le 90 Gi As Pr As Ile T 730 Gin A Met A Ser G Gly L 7 Giu L 810 Asn M Asn I Val i Val p Lys 890 u Ser 5 y Lys p Lys o Phe p Giu 970 yr sp la ly eu 95 ,eu et Prc ?h 31 87 As As Gi Pr Ly 91 Lys Lys Mi Asp Arg V 7' Asp Lou V 765 Asp Tyr I 780 Phe Thr L Lys Phe G Val Asn L His Lou C 845 e Gly Ile 860 Lys Thr
S
n Lys Lou n Val Lou y Gly Lys 925 o Lys Thr 940 s Ile Lou &I Lys Lys 11 su le et lr al 13 1 Th Le As As
G
A
A
Arg Ly Ile Se Ser Tt 7: Pro P 735 Lys I His G Asn r Ile G 8 Asn T 815 u Ile I y Ala r Lys Asp p Leu 895 n Lys le Thr 1n Val rg Arg sn Ile 975 Le hr le ly hr ly 00 hr sn Asn Glu Ile 880 Asn Ile Thr Thr Ile 960 Asp POUS 9 6/ 091 ?2
JPEP
1 US 18 DEC 1996 1372 980 INFORMATION FOR SEQ ID NO:1845: SEQUENCE CHARACTERISTICS: LENGTH: 371 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 1 .371 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1845 Arg Pro Phe Arg Ser Leu Ile Arg Ile Thr His Ala Pro Lys Leu Lys 1 Pro Ser Ph. 1 2 Met Giu Ile 'J Glu Asn Ala Sen Ala Ala Pro Ile Thr Phe Lys Pro Glu Lou Gin 115 Pro Lys Gly 130 Gly Giu Lys 145 Ile Lou Cys Phe Lou Cys Leu Lys Ile 195 Ile Giu Lys 210 Ser Met Thr 225 Phe Cys Lys Ser Leu Ala Ala Pro His 275 lia hr .eu Leu 100 Arg Met Thr Val His 180 110 His Let.
Pnr Lei 261 Phi Al Al L5 Leu G Leu P Ile 1I 85 MetI AlaI Thr Lou His 165 Sor Asp aAsp SLeu 245 1 Lys a Pro a Leu n Ala 325 iu C 'he A ,ys A [et P ~0 .yn C er .*yS L'hr -lu 150 Ala Val Giu Asn Asp 230 Ile Ala Sen Ile Glu 310 Leu ys lia ~ro ;iu 4 eu ksn ksn 13 5 Val G1u Lou Val Pro 40 Val Asn Giu Tyr Lys 120 Ala Lou Gin Giu Lou Ile 'I 25 Ile Lou C Lou Giu Ph.
105 Gly Gin Giu Ala Thr 185 Ser *Ala Gly Lys Lys 265 s His 'hr 1u 3er Ilie Asn Gly 170 Ph.
Asp rp Ala Tyr Lys 75 Lou Asp Lys Gly Ala 155 Ph.
Ala Tnp Giu His Ser Pro Lys Gly Ph.
Thr 140 Gin Cys Lou Arg Ala Lou Sen Lou Asn Lou Lou 125 Scr Lys Lou Sen Ser 205 Ile His Glu Ile Sen Thr 110 Lys Asp Lou Asp Ph.
190 Ile ksn la 1 Pro Asp Sen Lou Lou Lou Gly Lys 175 Pro Ala Sen Arg.
Ph.
Thn Asn Giu Tyr Leu Ph.
160 Giu Lys *Lou *Ile Cys 240 aLou SSer iGly e Glu n Ala 320 s Leu
S.-
Lou 215 Lou Lys His Lys Lou 295 Asn Asp 200 Lou Thz Prc Lya 281 Le~ Le~ As Thr Gly Lys 250 Ile Ser Lou Thr Lou 220 Son Lou Asp 235 Asp Gln Giu Son Pho Gly Ala Aen Ile 285 Lou CyS GiU 300 Phe Ile Son 315 Sen Lys Lye His Pro Arg Sen 270 Pro Lou Asp Ala His' His Let~ Asi Al~ Phi Asi Hi 33 Ile Lys 305 Lys Ph.
290 His Lys Sen Asn I le n Pro Gin Lou Ala Ala Pro 330 o} >i0-r PGT/US 96/0912.
IJPVNUS 18 DEC1996 1373 Ser Lys Lys Pro Phe Ile Val Pro Thr His Thr Leu Cys Leu Asn Glu 340 345 350 Lys Ile Ala Ile Leu Arg Gly Gly Giu Thr Leu Ser Trp Asn Leu Gin 355 360 365 Glu lie Ala 370 INFORMATION FOR SEQ ID NO:184 6 SEQUENCE
CHARACTERISTICS:
LENGTH: 231 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION 1...231 (xi) SEQUENCE DESCRIPTION: SEQ ID N0:1846 Glu Ile Tyr Met Pro Glu Asn Ser Lys Leu Gin Pro Ala Lys Leu Gly 1 5 10 Lys Asn Phe Asp Pro Val Asp His Ser Asn Arg Asn Phe Phe Phe Ser 25 Leu Ile Leu Ser Val Leu Leu His Trp Leu Ile Tyr Phe Leu Phe Glu 40 His Arg Glu Asp Phe Phe Pro Ser Lys Pro Lys Leu Val Lys Leu Asn 55 Pro Glu Asn Leu Leu Val Leu Lys Arg Gly His Ser Gin Asp Pro Ser 70 75 Lys Asn Asn Pro Gly Ala Pro Lys Pro Thr Leu Ala Gly Pro Gln Lys 90 Pro Pro Thr Pro Pro Thr Pro Pro Thr Pro Pro Thr Pro Pro Lys Pro 100 105 110 Ile Glu Lys Pro Lys Pro Glu Pro Lys Pro Lys Pro Lys Pro Glu Pro 115 120 125 Lys Lys Pro Asn His Lys His Lys Ala Leu Lys Lys Val Glu Lys Val 130 135 140 Glu Glu Lys Lys Val Val Glu Glu Lys Lys Glu Glu Lys Lys Val Val 145 150 155 160 Glu Gin Lys Val Glu Gin Lys Lys Ile Glu Glu Lys Lys Pro Val Lys 165 170 175 Lys Glu Phe Asp Pro Asn Gin Leu Ser Phe Leu Pro Lys Glu Val Ala 180 185 190 Pro Pro Arg Gin Glu Asn Asn Lys Gly Leu Asp Asn Gin Thr Arg Arg 195 200 205 Asp Ile Asp Glu Leu Tyr Gly Glu Glu Phe Gly Asp Leu Gly Thr Ala 210 215 220 Arg Lys Arg Phe His Gln Glu 225 230 INFORMATION FOR SEQ ID NO:1847: SEQUENCE
CHARACTERISTICS:
RAZ LENGTH: 206 amino acids TYPE: amino acid
O-
WJJ
T" Pg 9 /091? 1374 TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...206 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1847 Ser Arg Tyr His Pro Arg Gly Phe Ser Gln Leu Pro Lys Leu Lys Leu 1 5 10 Ile Cys Ile Thr Ala Thr Gly Thr Asp Asn Val Asp Ile Lys Ser Ala 25 Lys Ala Leu Gly Ile Giu Val Lys Asn Val Ser Ala Tyr Ser Thr Glu 40 Ser Val Ala Gln His Thr Leu Ala Cys Ala Leu Ser Leu Leu Gly Arg 55 Ile Asn Asp Tyr Asp Arg Tyr Cys Lys Ser Gly Glu Tyr Ser Gin Ser 70 75 Asp Ile Phe Thr His Ile Ser Asp Ile Lys Met Gly Leu Ile Lys Gly 90 Gly Gin Trp Gly Val Ile Gly Leu Gly Asn Ile Gly Lys Arg Val Ala 100 105 110 N Lys Leu Ala Gin Ala Phe Gly Ala Lys Val Val Tyr Phe Ser Pro Lys 115 120 125 Asp Lys Lys Glu Glu Tyr Glu Arg Leu Ser Leu Glu Glu Leu Leu Lys 130 135 140 Thr Ser Gly Ile Ile Ser Ile His Ala Pro Leu Asn Glu Ser Thr Arg 145 150 155 160 Asp Leu Ile Ala Leu Lys Glu Leu Gin Ser Leu Lys Asp Gly Ala Ile 165 170 175 Leu Ile Asn Val Gly Arg Gly Gly Ile Val Asn Glu Lys Asp Leu Ala 180 185 190 Leu Ile Leu Glu Thr Lys Asp Leu Tyr Tyr Ala Ser Asp Val 195 200 205 INFORMATION FOR SEQ ID NO:1848: SEQUENCE CHARACTERISTICS: LENGTH: 106 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...106 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1848 Ile Leu Glu Asn Leu Arg Ile Tyr Ala Arg Leu Leu Glu Met Ile Leu 1 5 10 POT/US 9 6 091 1P vUd 13 c 1996 1375 Lys Asn Leu Ile Leu Leu Phe Leu Ala Lys Arg Lys Leu Ile Phe Ile 25 Glu Ala Asn Phe Tyr Thr Ile Ser Gly Ser Lys Leu Asn Glu Val Ala 40 Arg Ser Tyr Gin Asp Leu Ala Leu Lys Phe Giu Ala Phe Pro Asn Tyr 55 Glu Phe Ile Trp Ile Thr Asp Gly Ile Gly Trp Leu Asp Ala Lys Ser 70 75 Lys Leu Gln Glu Ala Tyr Lys Ser Val Glu Ile Tyr Asn Leu Ser Tyr 90 Val Asn Asp Phe Ile Ser Lys Val Gln Lys 100 105 INFORMATION FOR SEQ ID N0:1849: SEQUENCE CHARACTERISTICS: LENGTH: 119 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...119 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1849 Cys Val Met Leu Met Ala Ile Phe Thr Pro Tyr Ile Leu Ile Leu Lys 1 5 10 Met Met Lys Lys Ser Met Ser Leu Phe Ala Asn Met Gly Leu Glu Gin 25 Ile Phe Cys Asn Arg Asp Ile Lys Asp Leu Asn Asp Phe Val Phe Gly 40 Ile Glu Val Gly Leu Asp Ser Asn Ala Arg Lys Asn Arg Ser Arg Lys 55 Ala Met Glu Asn His Leu Ile Gly Leu Phe Val Gin Ala Gin Leu Asn 70 75 Phe Lys Glu Gin Val Asp Ile Arg GIu Phe Glu Asp Leu Arg Gln Ala 90 Phe Gly Asa Asp Thr Lys Lys Phe Asp Phe Val Ile Phe Ser Lys Glu 100 105 110 Lys Thr Tyr Phe His Arg Ser 115 INFORMATION FOR SEQ ID NO:1850: SEQUENCE CHARACTERISTICS: LENGTH: 304 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori T F. PT/US 96/091 2..
PEA/U3 l10 DEC 996 1376 (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...304 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1850 Leu 1 Ala I Val Leu Thr Thr Ser Ala Ala Ala 145 Asp Lys Ser Asp Asn 225 Ile Lys Glu Phe Val .eu Gln Gin 50 Arg Leu Arg Tyr Asp 130 Ile Asn Gly Asn Met 210 Gin Tyr Gli Ar As 291 Ile Asn Ser I 5 Gly Lys Ala Ser Tyr Glu Lys Ala Ser Pro Thr Asn Glu Gin Thr 85 Asp Asn Gin 100 Asn Glu Leu 115 Thr Lys Ile Arg Ser Ser Gly Val Glu 165 Val Met Ser 180 Pro Lys Ala 195 Gly Gly Arg Val Ile Ala Glu Asp Ser 245 Asn Ala Gin 260 g Phe Ala Ala 275 n Ser Val Gin Lys Ser Ala Asp Glu 70 Thr Ala Ile Ala Leu 150 Ser Leu Thr G1u Asn 230 Leu Glu r Thr Gly Leu Leu Thr Ile L Leu Ser Ser 55 Val Glu Ile Pro Gly 135 Asn Leu Asp Gin Ile 215 Leu Asp Leu
C
A
P
I
Lt
I
A
M
10 ys Asp Leu Gly I 25 in Asp Thr Leu I 0 in Phe Thr Tyr sn Asp Val Ile ro Asn Lys Pro 90 lie Asp Ser Leu 105 ys Leu Asp Glu .20 :le Phe Asn Gly sn Val Phe Ser 155 let Lys Tyr Gly 170 Slu Ala Lys Leu 185 Asp Phe Phe Tyr 200 His Gin Glu Gly Ile Asp Gly Gly 235 Arg Asp Ala Lys 250 Leu Lys Thr Arg 265 Ser Gin Ile Ser 280 Ile Asp Gin Ala Leu S Phe M 4 Asn C Ser C Ala Lys C Asp Val 140 Tyr Leu Ser Gly Ile 220 Asn Ser Tyr Lys Ala 300 ,ys er [et ly ;ly Ile Glu Thr L25 Gly Ser Ser Ser Ser 205 Phe Ala Leou Asn Ala Gly Glu 15 Ala Gly 1 30 Ser Lys Val Ser Val Asn Ile Ser 95 Phe Val 110 Arg Tyr Asp Ile Val His Leu Asp 175 Ala Leu 190 Asp Ser Ser Lys Lys Leu Thr Lys 255 Ile Met 270 Asn Gin sp Met Asn Ile Ile Val Lys Asp Arg Thr 160 Asp Asn Lys Phe Lys 240 Asp Ala Lys Tyr Asp Met Met 295 285 Ala Lys Lys Asn 0 INFORMATION FOR SEQ ID NO:1851: SEQUENCE CHARACTERISTICS: LENGTH: 129 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...129
?Q"
RA f
T
1377 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:l851 Arg Asn Ile Met Gin Tyr Ala Asn Ala Tyr Gin Ala Tyr Gin His Asn 1 5 10 Arg Val Ser Val Glu Ser Pro Ala Lys Lou Ile Giu Met Lou Tyr Glu 25 Gly Ile Lou Arg Phe Sor Sor Gin Ala Lys Arg Cys Ile Glu Asn Giu 40 Asp Ile Giu Lys Lys Ile Tyr Tyr Ile Asn Arg Val Thr Asp Ile Ph.
so 55 Thr Glu Leu Lou Asn Ile Lou Asp Tyr Glu Lys Gly Gly Lys Val Ala 70 75 Val Tyr Lou Thr Gly Lou Tyr Thr His Gin Ile Lys Val Lou Thr Gin 90 Ala Asn Val Giu Asn Asp Ala Ser Lys Ile Asp Lou Val Lou Asn Val 100 105 110 Ala Arg Gly Lou Lou Giu Ala Trp Arg Giu Ile His Sor Asp Glu Lou 115 120 125 Ala INFORMATION FOR SEQ ID NO:1852: SEQUENCE
CHARACTERISTICS:
LENGTH: 83 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature.
LOCATION .83 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1852 Ph. Asp Asp Lou Tyr Gly Ser Asn Sen Lou Pro Ph. Tyr Pro Arg Val 1 5 10 Thn Pro Val Lys Ph. Pro Thr Ph. Lys Tnp Ala Lou Lou Lys Ala Lou 25 Ile Lys Asp Asp Ph. Pro Thr Lou Gly Trp Pro Thn Ang Ala Thr Met 40 Ile Ser Ph. Ile Gly Ph. Glu Cys Sen Ala Lou Lys Val Phe Leu Ile 55 Phe Gly Tyr Ile Val Ph. Lys Ser Trp His Tyr Son Ala Ile Arg Lou 70 75 Ile Val Ile INFORMATION FOR SEQ ID NO:1853: SEQUENCE
CHARACTERISTICS:
LENGTH: 220 Amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein '~NT O'f PCT/US 9 6 0 912 2 IPENL3 38 DEC1996 1379 (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...220 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1853 Lys 1 Val Phe Glu His Phe Phe Glu Pro Phe 145 Glu Val Gly Pro Asp Asp Leu Gin Ile Lys Ser Gin 115 Leu Ser Phe Gly Phe 195 Leu Lys Ile Lys Lys Ile Val Glu 100 Pro Thr Gin His Leu 180 Asp Arg Asn Val Lys Met 5 Glu Glu Glu Ser Gly Lys Arg Leu Glu Leu 165 Asn Val Pro Thr Asp Lys Iie 70 Asn Glu Leu Lys Asn 150 Asp Leu Ser Lys Ile Asp Ser Ala Phe Leu Ile Ala 135 Lys Leu Asn Gly Gly 215 Pro Ala 40 Gly Ala Gly Leu Ser 120 Leu Trp Met Gly Asp 200 Gly Arg Asn 25 Leu Ser Val Gin Glu 105 Phe Lys Glu Asp Val 185 Leu Lys Lys 10 Ile Lys Glu Ile Lys 90 Asp Asn Tyr Asn Ser 170 Cys Val Arg Gly Ser Ile Phe Gly 75 His Phe Gly Asn Tyr 155 Leu Ser His His Arg Leu Cys Leu Asp Glu Phe Arg Leu 140 Arg Ser Met Ala Tyr 220 Val Cys Glu Pro Asp Asn Lys Gly 125 Thr Ala His Thr Ile 205 Met Lys Trp Leu Tyr Lys Tyr 110 Phe Leu Arg Tyr Asn 190 Tyr Leu Glu Ser Tyr Gly Glu Phe Asp Asp Tyr Gly 175 Ile Tyr Cys His Phe Leu Gin Asp Asn Ile Ala Ser 160 Ser Pro Asn INFORMATION FOR SEQ ID NO:1854: SEQUENCE CHARACTERISTICS: LENGTH: 254 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...254 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1854 Arg Phe Lys Ala Arg Ile Val Arg Phe Phe Ile Phe Leu Ile Leu Ile RA. 1 S 10 f Cys Pro Leu Ile Cys Pro Leu Met Ser Ala Asp Ser Ala Leu Pro Ser 25 PCTUS o0 9 12.a 1379 Val Asn Lou Ser Leu Asn Ala Pro Ser Asp Pro Lys Gin Lou Val Thr 40 Thr Lou Asn Val Ile Ala Leu Lou Thr Leu Leu Val Leu Ala Pro Ser s0 55 Lou Ile Leu Val Met Thr Ser Phe Thr Arg Leu Ile Val Val Ph. Ser 6S 70 75 Phe Leu Arg Thr Ala Lou Gly Thr Gin Gin Thr Pro Pro Thr Gin Ile 90 Lou Val Ser Leu Ser Leu Ile Lou Thr Phe Phe Ile Met Giu Pro Ser 100 105 110 Leu Lys Lys Ala Tyr Asp Thr Gly Ile Lys Pro Tyr Met Asp Lys Lys 115 120 125 Ile Ser Tyr Thr Giu Ala Ph. Giu Lys Ser Thr Lou Pro Phe Lys Giu 130 135 140 Phe Met Lou Lys Asn Thr Arg Giu Lys Asp Lou Ala Lou Phe Ph. Arg 145 150 155 160 Ilie Arg Asn Lou Pro Asn Pro Lys Thr Pro Asp Asp Val Sor Lou Ser 165 170 175 Val Leu Ile Pro Ala Ph. Met Ile Sor Giu Lou Lys Thr Ala Phe Gin 180 185 190 Ile Gly Phe Lou Lou Tyr Lou Pro Phe Lou Val Ile Asp Met Vai Ile 195 200 205 Ser Ser Ilie Lou Met Ala Met Gly Met Met Met Lou Pro Pro Vai Met 210 215 220 Ile Ser Lou Pro Ph. Lys Ile Lou Val Phe Ile Lou Val Asp Gly Phe 225 230 235 240 Asn Lou Leu Thr Giu Asn Lou Val Ala Ser Phe Lys Met Val 245 250 INFORMATION FOR SEQ ID NO:1855: SEQUENCE
CHARACTERISTICS:
LENGTH: 614 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc..feature LOCATION 1 614 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1855 Lys Trp Gly Ile Lou Pro Gly Lou Pro Val Asp Lys Met Giu Val Sen 1 5 10 is Lou Ile His Lys Asp His Gin Ile Thn Ile Ile Asp Lou Pro Gly Thr 25 Tyr Ala Lou Asn Asp Phe Thr Thr Glu Giu Lys Val Thr Lys Asp Ph.
40 Lou Giu Lys Gly Gin Tyr Asn Lou Ile Lou Asn Val Val Asp Ser Thn' 55 Asn Lou Giu Arg Asn Lou Ala Lou Sen Ala Gin Lou Lou Asp Thr Asn 70 75 Lys Lys Met Lou Lou Ala Lou Asn Met Trp Asp Giu Ala Lys Lys Giu 90 Gly Ile Asn Ile Asn Thr Giu Lys Lou Sen Gin Giu Lou Gly Val Val 100 105 110 Cys Val Pro Thr Ser Ala Ang Ser Lys Giu Asp Arg Lou Asn Thr Giu PCT/US 96/0912.2.
'J I 20E C1996 1380 Leu I Asn 145 Tyr 5 Lys Met Ile Glu 225 Asn Gly Ile Leu Pro 305 Arg Gly Gly Tyr Leu 385 Lys Lys Leu 130 Giu Ser Gin His Phe 210 Glu Glu Ala Ser Asp 290 Leu Thr Phe Ser Ile 370 Ser Tyr Se 115 Leu I Asn Gin Asn Gin 195 Ser Gly Asp Thr Leu 275 Giy Ile Leu Met Phe 355 Leu Val Arg r Leu Asp Ile Ser Ala 180 Arg Leu Phe Leu Val 260 Leu Ile Thr Gin Ser 340 Phe Gly Phe Phe Ser
C
120 ;iu Ile Val Arg Lou Tyr Ser
C
Lys Ala 165 Ser Tyr Ser Lys Ala 245 Ser Glu Leu Gly Asn 325 Cys Pro Ala Lys Pro 405 Val 150 iln Phe Gly Phe Ile 230 Ser Phe Thr His Phe 310 Tyr Ser Ser Val Gly 390 5cr 135 Pro Arg Glu Ile Lou 215 Leu Lau Leu Thr Lys 295 Gly Asn Ala Ser Val 375 Gin Trp Ser Ile His Phe 200 Ile Ser Val Pro Gly 280 Phe Cys Giu Arg Ser 360 Ala Thr Arg Lys Gin Ala Thr 18S Ile Gly Asp Gly Leu 265 Tyr Gly Ser Arg Leu 345 Ala Leu Glu Met Ala 425 Gin Ser Lys 170 Tyri Phe Gly Ser Asp 250 Ile Met Leu Val Lou 330 Pro Gly Val ser Val 410 Gly Tyr ?he 155 Ser jys Leu Gly Ile 235 Gly Val Ser His Pro 315 Ile Ile Phe Met Phe 395 Tyr Thr Pro Gn 140 Lys Val Ile Gly Val 220 L~ys Ile Val Arg Gly 300 Ala Thr Tyr Val Ala 380 Ile Phe Tyr Lys 125 Asn T Giu S Ile S Asp Phe b 205 Gin I Glu Ile Lou Val 285 Lys Tyr] Lou Val Lou 365 Lys Met Ser Ile Asfl hr er er .90 Met Lys Asn iy Tyr 27 0 Ala Ser Met Phe Lou 350 Phe Lou Glu Ile Leu 430 Asi Thr Leu Glu 175 Ile Phe Ala Val Gly 255 Phe Phe Phe Ala Val 335 Phe Cys Leu Met Tyr Val Ala Asn Lys 160 Asn Leu Ile Leu Ala 240 Val Gly.
Lou Ile Thr 320 Ile Val Ile Lys Pro 400 Thr Gly Ala Tyr Lou Lys Ala Ile Lou Ile Trp Phe Met Ser 44A 435 Met Lou 465 Lau Tyr Val Leu Phe 545 Ph.
Thr Ile Ala Lys Thr Tyr 450 Se Ser Glu Asp LyS Lys Lou Glu Ly8 Ser Lou Val 515 Gly Val Lou 530 Arg Glu Ile Ile Val Phe Phe Gly Arg 580 Phe Thr Thr 595 Thr Gin Ile 610 .ys Gin Glu Ser Lou Lou Val Gin Lys Asn 455 460 Ala Asn 485 Val Thr Phe Ile Val 565 Glu Val Leu Lys 470 Lou Phe Gly Ser Arg 550 Met Ala Val Val Glu Lys Asn Phe Leu 535 Lys Phe Gly Ala Giu: Asn Pro Met 520 Gly Glu Tyr Gly Tyr 600 Lys Ser Met Ala Asp Val Ile 110 585 Ala Leu Lys 475 Val Val 490 Asp Phe Lys Glu Gin Asn Ser Val 555 Pro Cys 570 Lys Phe Phe Ser 31y Gly Asp Val Giu 540 Pro Phe Val Leu Leau Arg Trp Val 525 Lys Ser Ala Ala Ile 605 Lys Gly Arg 510 Val Ser Gly Ala Tyr 590 Ala Ala Thr Gly.
495 Lou Ser Asp Ile Thr 575 Leu Phe Asn Glu 480 Ala ser Thr Ala Ala 560 Ile Phe Tyr 96,/0912a2 1.21996 1381.
INF'ORMATION4 FOR SEQ ID NO:i856: SEQUENCE CHARACTERISTICS: LENGTH: 325 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .325 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:l856 Met Lys Arg 1 Ala Val Lys Asn Asp Lys Tyr Met Gly so Ala Asn Gin Ile Arg Asn Gly Phe Gly Val Ann Gly 115 Val Ile Ph.
130 Lys Gly Gly 145 Ile Asn Ile Ser Giu Arg Asn Gin An 195 Ph. Asn Thr 210 Ile Gin Ala 225 Ser Pro Thr Asn Asp Ser Leu Thr Asp 275 Ph. Gin An 290 Trp Gly Ala 305 Gly Gly Ph.
Ile Leu Val Ser Leu Ala Val Leu Ser His S ion P1 rhr 7,lu Ser Ser Ser Alia 100 Ile Pro Giu Ile Thr 180 Son Tyr Gin Asp An 260 Pro An Val His 5 His Asn Ala Pro Ang Thr Ile Giu 70 Thn Gly Gly Gly Pro Ile Val Thr Sen Val 150 Thr Lys 165 Thr Ph.
Lys An Lou Arg Val An 230 Ile Gin 245 *Lys Ile Giy Sen Arg Pro *Tyr Gin 310 Ph.
325 Leu C Leu Val 55 Glu Ile Pro Tyr' Ph.
135 Arg Gly Tnp Ile Thr 21i5 Trp An Thr Lou An 295 ;iu ;er L0 Il.
ily 120 T'yr Ile Gly Asp 200 Gly Lou Ala G1j 28C Asi Ang 25 Trp Ser Leu Aia His 105 Ala Sen Gly Pro Lys 185 Lys *Giy *Lys *Met Ph.
265 Sle i Asp krg ksn I 1ln Sen Pro Val Pro Thr 170 Son Ser Met Giy Leu 250 Ph.
Ala Lys ;iu Aia Sen Gly ion Lys Glu Val ,ys Gin Leu Thr sn Val Pro.Gly Fs )ro Ser Ile Ser sn Thr Gly Met 110 D'yr Val Giu Ile 125 k.sp Arg Ile Ser 140 ksn Ala Ph. Gly L55 ksn Trp, Giu Sen 3iu Asn Gly Gly 190 Leu Val Ann An 205 Hot Ann Lys His 220 Gin Gly Phe Arg 235 Asp Son Leu Tyr Gin Tyr Tyr Son 270 Ala Tyr Ann Gin 285 Ser Gly Arg Ala 300 Asp Thr Asp Ang 315 ~la ali ~rg fal Ile El.
,iy 2iy 17S Ph.
met Ph.
Tyr Gin 255 Tyz Asr His Ala Asn Son His' Arg Leu Thr Thr Val 160 Val Ph.
Lou Gly An 240 Ile Ph.
iArg Lys Ang Val Gly 320 Ann Ph. Ph. Gly INFORMATION FOR SEQ ID NO:1857:
'T
t\ AITj C PCT/US 96/091220 (PiUD 12 DEC 1996 1382 SEQUENCE CHARACTERISTICS: LENGTH: 797 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .797 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1857 Arg Leu Lys Pro Asn Val Ile Glu Arg Arg Met Leu 1 Ser Lys Glu Leu Leu Ala Gin Lys Ser 145 Asn Gin Lys Asn Asp 225 Gin Ala Tyr Val Ser 305 Thr Ala Leu Ala Ser His so Glu Phe Arg Ser Glu 130 Leu Arg Glu Leo Gly 210 Ser Gbu Tyr Gin Asn 290 Asn Lys Pro Leu Ile Tyr Phe Gly Thr Leu Asp 115 Val His Glu Thr Leo 195 Phe Tyr Ser Glu Glu 275 Lys Leu Arg Ser Phe 355 Lys Ser Leu Val G1u Val 100 Ser Tyr Gly Asn Leu 180 Asn Glu 1e Phe Ser 260 Thr Thr Val Leu Leu 340 Lys 5 Gin Met Leu Ser Arg Val Gin Glu Val Phe 165 Lys Ser Leo Ala Asn 245 Glu Pro Leu Lys Ser 325 Glu Glu Lys Ser Thr Tyr 70 Gin Lys Tyr Asn Leo 150 Lys Ser Lys Pro Ser 230 Gin Arg Leu Ser Asn 310 Met Asp Asn Val Glu Lys 55 Thr Met Arg Leo Gin 135 Glu Asp Lou Glu Leo 215 Ser Lys Ile Asp Phe 295 Giu Gin Leu Let: Ser Asn 25 Glu Asn 40 Asn Glu His Leu Ala Leu Arg Lys 105 Gin Ala 120 Tyr Phe His Lys Ile Leou Glu Ile 185 Val Leu 200 Lys Pro Ile Thr Thr Tyr Thr Ser 265 Ile Ile 280 Leu Lys Leu Leu Lys Phe Asp Ala 345 10 ryr Asn Asn Ser Asp 90 Ile Ile Leu Lys Ser 170 Gin Asn Leu Phe Asn 250 le Phe Glu Glu Ala 330 Gin Phe Ile Leu Thr 75 Ser Asp Leu Val Lys 155 Tyr Leu Phe Val Glu 235 Arg Ala Ser Arg Tyr 315 Leu Thr Leu Leu Val G31 Leu Tyr Asn Leu 140 Ser Lys Lys Tyr Gly 220 Lys Leu Val Ile Ala 300 Girn Asn Ser Glu Gly Gly 1 Gly Gin Gu I Lys Gin 125 Glu Phe Ala Asn Ala 205 Gly Asp Ile Gly G1u 285 Lys Glu Val Leu Thr 365 Lys Val Leu Ile Leu ys Gin 110 Phe Ser Met His Tyr 190 Gbu Tyr Tyr Gly Ala 270 Pro Phe Let Let.
11 Leou I Leu I Tyr Le u Gin Val Ser Glu Thr His Phe 175 Ala Tyr Leu Phe Ile 255 Leu Met Ser Val Ile 335 t Leu .eu Pro Asp Arg Asp Val Ile Asn His Ala 160 Leu Pro I1 Ser 11e 240 Lys Leu Ser Met Lys 320 Lys Gly 350 Phe Gly Leu Val 360 Gly Val Ile Glt PCT/IJS 96/091za IPENr 1Z C 1996.
1383 Lys Arg 385 Glu Leu His Asn Leu 465 Leu Phe Cys Leu Asp 545 Tyr Thr Pro Asn Leu 625 Asn Glu Arg Leu Leu 705 Asn Leu Asn Phe Asp 785 Gly 370 Leu Arg Ser Asn Gy 450 Ile Leu Lys Leu Ser 530 Met Pro Ser Leu Val 610 Leu Asp Asn Lys Ser 690 Ile Val Tyr Met Asn 770 Tyr Gly Arg Gin Val Gin 435 His Ser Ala Gly Glu 515 Met Asn Lys Ser Phe 595 Ile Ala Ser Asp Ala 675 Gly Leu Pro Ala Ile 755 Ser Pro ryr Phe Asn Phe 420 3lu Thr Tyr Phe His 500 Pro Leu Ala Asp Asn 580 Asn Asn Tyr Gly Leu 660 Asn Val Tyr Lou Arg 740 Asp Asp Thr Phe Leu Leu 405 Lys Val Leu Leu Asp 485 Tyr Asn Asp Ile Phe 565 Gin Ala Leu Tyr Phe 645 Leu Gly Lys Pro Ser 725 Gin Val Ser Giu Ser Thr 390 Gly Asn Ser Val Met 470 Arg His Leu Leu Ser 550 Ser Leu Leu Asp Leu 630 Lou Asn Val Asn Gin 710 Glu Val Ser Ser Trp 790 Phe 375 Ser Phe Leu His Ile 455 Met Met Asp Gin Ala 535 Gly Leu Gly Asn Ala 615 Phe Val Thr Val Ala 695 Lys Thr Lou Leu His 775 Arg Phe Lys Lys Asp Asn 440 Gly Ser Gin Gly Asn 520 Pro Ala Leu Lou Asp 600 Ile Tyr Phe Lys Val 680 His Asn Glu Val Gllu 760 Val Glu Pro Ala Ala Tyr 425 Asn Ala Ala Gly Gin 505 Leu Ser Ile Asp Ser 585 Ala Thr Lys Leu Ile 665 Lou Ser Ala Ile Lys 745 Gly Asn Lys ;lu Leu Asn 410 Ser Ala rhr Leu Leu 490 Ser Glu Arg Lys Phe 570 Lou Phe Gin Ile Asp 650 Asn Ala Phe Arg Ser 730 Asn Lou Lys Leou Arg Ala 395 Ser Pro Lys Gly Lys 475 Tyr Phe Phe Asp Ser 555 Lys Glu Asn Asn Leu 635 Glu Ala Leu Lou Glu 715 Phe Lou Gly Val Lou 795 Ile 380 -ys rrp Phe Glu Ser 460 Tyr Ser Ser Leu Lys 540 Leu Glu Pro Ser Pro 620 Glu Phe Lou Gin Ser 700 Lou Lou Gly Cys Lys 780 Lys His Lou Gly Lou Ile 445 3ly .,in Ph* Ile Gin 525 Glu Tyr Thr Tyr Asn 605 Lys Giu Lys Ile Asp 685 Asn Lys Glu Asn Tyr 765 Ala Sex Leu Met Asn Phe 430 Ala Lys Asn Thr Asn 510 Ser Ala Giu Lou Leu 590 Ala Asp Ser Ser Thr 670 Ile Met His Asn Gly 750 Lou Leot Asn His Val Phe 400 Ser Pro 415 Asn Phe Arg Val Ser Thr Met Arg 480 Giu Phe 495 Pro Phe Phe Phe Leu Glu Thr Leu 560 Lys Arg 575 Asn Asn Phe Lou, Leu Gly Arg Lys 640 Tyr Val 655 Gin Ala Tyr Gin Gly Thr Asn Phe 720 Thr Pro 735 Ser Ser Lys Ile Gin Lys INFORMATION FOR SEQ ID NO:1858: SEQUENCE CHARACTERISTICS: LENGTH: 529 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein tLJ T PCTIUS 0Ci WEAUl2 D80EC 1996 1384 (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION .529 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1858 Lys Met Ile Leu Lys Ser Ser Ile Asp Arg Leu Leu
C
1 Ile Asn Ser Ser Val Tyr Glu Phe Ala 145 Asn Lys Met Arg Lys 225 Glu Asp Leu Asp Ala 305 Gly Asn Phe Asp Lys 385 Thr Val Tyri Val Gly Glu Asp Met Leu 130 Phe Lys Ser Phe Thr 210 Leu His Val Gly Pro 290 Ala Val His Ile Pro 370 As& Leu Giu Met Asa Asp Ala Lys Val 115 Asn Lys Gly Asp Pro 195 Leu Phe Ile Ile Thr 275 Glu, Tyr Ile Gin Glu 355 Leu Phe Leu Val Ala Gin Ser Leu Gly 100 Ser Tyr Leu Leu Lys 180 Ile Lys Asp Tyr Lou 260 Ala Ile Lys Leu Ile 340 Phe Glu Ser Gin 5 Ile Cys Val Ile Glu Val Ser Leu Gly Asn 165 Giu Tyr Glu Lys Lys 245 Lou Leu Leu Ala Phe 325 Glu Val Lys Leu Ala 405 Ser Cys Lys Lys 70 Lys Tyr Leu Gin Leu 150 Lys Asp Ser Lys Ser 230 Gin His Thr Lau Ser 310 Glu Thr Leu Asp Leu 390 Pro Ser Pro Gly 55 Phe Leu TyrJ Tyr Lys 135 Cys Asp Lys Pro Ala 215 Ser Lys Gin Pro Ser 295 Leu Asn Leu Arg Lys 375 Leu Leu Tyr ?he 40 ?he Val Ala Asp Gln 120 Arg rhr Lys Thr Ser 200 Ala Leu Gin Ala Ser 280 Tyr Met Asn Lys His 360 Ala Gir His Val 25 His Tyr Met His His 105 Glu Gly Asn Leu Tyr 185 Ala Lys Lou Val Gly 265 His Asp Lou Lou Asn 345 Met Leu Asn Val 10 Asp ;lu yr Ala Arg 90 Lys Glu Lou Lys Ile 170 Lou Gin Tyr Tyr Ile 250 Phe Lou Gly Ala Asp 330 Trp Ala Lys Glu Leu 410 GiL Leu I Glu I Cys I Phe C 75 Phe 3 Glu Lou Ser Ile 155 Giu Arg Val 11 Gly' 235 Val Lys.
Pro Asp Lys 315 Pro Lou Gly Glu Tyr 395 Gly Lys Arg I Arg 1 Phe Giu Asn Asp ?he Met 140 Asp Leu Phe Vali Asn 220 Tyr: Thr Asn Lou Lys 300 Giu Ala Ser Ser Met 380 Lys Ile Pro Gn Lys Ser ly Lys Ile Tyr Asn 125 Glu Tyr Gly Leu Gly 205 Ser His Glu Ala Leu 285 Ala Gin Asp Arg T!r 365 Leu Pr Ar As Thr Ser C Ala Cys C Leu Ala His 110 Ala Ser Gly Val Asp 190 Phe Pro Lou Gly Ile 270 Lys Gly Arg Met Pro 350 Lou Gly o Lou g Glu n Arg 430 Ile Gly Ser Gly er Leu Ljeu Pro Ile Ile Lou 175 Arg Gly Gln Ala Tyr 255 Ala Lys Arg Lys Ile 335 Ile Let.
Phi I1 Pr 41 Pr Asp Ser Phe Ala Phe Glu Lou Phe Lys Glu 160 Gly Ile Gly Asn Lys 240 Leu Thr Gly Asn Gly 320 Ala Ala Asp Lou B Ala 400 o Val o Gin AL LU Ser Phe Gin Pro Phe Tyr Pro Lys Thr
-T
POUS 96/0912.2 IPEA/U3o 13DEC1996 Lys Lou Val1 465 Asp Leu Lou Pro Phe Val 450 Gly Ala Lou Arg Ser Lou Ser 470 Glu Leu Lou Ser Lou 455 Gly L~ys Pro Arg 138S Leu Giu Ser Lou 460 His Lys 475 Pro Lys Gly Gly Pro Pro INFORMATION FOR SEQ ID NO:1859: SEQUENCE CHAR~ACTERISTICS: LENGTH: 430 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .430 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:18S9 Toii Ara Glv His Arg Arg Thr Tyr Ile Gly Sen Met Pro 1 Val Gin Gly Asp Giu Ile Ala His Thn Glu Ala Pro Lys 145 Thr Lys Leu Tyr Ala Phe Lys Ser 130 Tyr Ile Lys Lou Ala AMn Asn 115 GiU Thr Met Giy 19E Prc ,Pr~ Lou Asp Giu Asn Asn Sor 100 Vat Arg *Arg 180 Asn Asp Sle
I
Ile Lou Ph. Ser 70 Ile Asp Val Son Lou 110 Asp Ilo Giu Ala 150 Lys Ala 165 Thr Lys leo .4's A~la Asp Asp 55 Ile Arg Sor Pro Sor 135 Gly Lyx Arg 40 Pro Asp Ile Tyr Gin 120 His Val Lys 25 Ser Glu Lou Pro Thr 105 Giu GlU Arg Met Val Gin Sor Ala 90 Pro Lou Cys Asp Tyr 170 Asp Ser Lou Ile Lsn Pro ~rg Gly ksn Ite ;in Vat 75 Pro Lou Sor Giu Glu Lys Lou Lys 140 Lou Ang 155 Lou Gtu Lys Asp Lys Asp Giu Arg 220 Gly Ile tat ksp Ile Arg Lys His 125 Lou Ang Asp Lys Phe 205 Met Val Gly Arg I Met Vat L Pro Ala S Ph. Arg Ph. Ito I Asp Arg Gtu Gtu 110 Ala Lou It. Ile Gin Ile Asn Pro 175 Lys Gly 190 Cys Vat Val Ph.
Asn Giy eu ler (ot Giu Ala 160 His Gly Sen G iu Lou Ala Lou Lys Lys Ser Gtu 185 Asn Giu Ito Thi 21( Ito Asi Giu Asn Asp Lys Lou Giu Arg Gly Giu 200 Lys Gtu Tyi 215 Giu Asn Ly~ Q~T~j iPEN A '996 1386 225 230 235 240 Ala Trp Thr Pro Val Gly Gly Asp Val Leu Lys Ile Glu Ala Val Lys 245 250 255 Ile Arg Gly Lys Gly Glu Leu Lys Leu Thr Gly Ser Leu Gly Asp Val 260 265 270 Met Lys Glu Ser Ala Ile Ile Ala Phe Ser Val Val Lys Val Leu Leu 275 280 285 Asp Asn Glu Thr Leu Lys Val Pro Lys Ile Pro Ser Glu Thr Asp Ala 290 295 300 Glu Asn Lys Lys Lys Lys Lys Val Leu Lys Val Tyr Asn Ala Tyr Asp 305 310 315 320 Leu His Leu His Val Pro Glu Gly Ala Thr Pro Lys Asp Gly Pro Ser 325 330 335 Ala Gly Ile Ala Met Ala Ser Val Met Ala Ser Ile Leu Cys Asp Arg 340 345 350 Ala ile Arg Ser Glu Val Ala Met Thr Gly Glu Leu Thr Leu Ser Gly 355 360 365 Glu Val Leu Pro Ile Gly Gly Leu Lys Glu Lys Leu Ile Ala Ala Phe 370 375 380 Lys Ala Gly lie Lys Thr Ala Leu Ile Pro Val Lys Asn Tyr Glu Arg 385 390 395 400 Asp Leu Asp Glu Ile Pro Thr Glu Val Arg Glu Asn Leu Asn Ile Val 405 410 415 Ala Val Lys Asn Ile Ala Glu Val Leu Glu Lys Thr Leu Leu 420 425 430 INFORMATION FOR SEQ ID NO:1860: SEQUENCE CHARACTERISTICS: LENGTH: 272 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (Lii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION 1...272 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1860 Lys Arg Tyr Arg Lys Thr Ala Leu Leu Arg Leu Asp Asn Gly Asp Lys 1 5 10 Leu Ser Leu Met Arg Glu Phe Phe Lys Ser Val Arg Gly Phe Leu Asn 25 Leu Leu Arg Met Ile Phe Pro Glu Arg Phe Gin Asn Ala Phe Leu Gly 40 Leu Ser Glu Leu Phe Tyr Tyr Ala Ser Ser Leu Ser Phe Tyr Thr Ile 55 Leu Ser Leu Ser Pro Ile Leu Leu Phe Val Phe Ser Leu Phe Val Ser 70 75 His Tyr Leu Gin Ala His Ser Gly Glu Met Glu Ala Leu Ile Phe Pro 90 Asn Ala Pro Lys Leu Ile Gly Ala Ile Lys Asp Phe Leu Glu Asn Phe 100 105 110 Lys Lys Thr Asp Met Thr Leu Gly Thr Leu Glu Glu Val Ser Ile Val 115 120 125 0A Val Ala Leu Val Leu Phe Cys Glu Asn Tyr Arg Ser Ile Ala Ser Lys 130 135 140 PCTU 9 6/O0912 fPEPfl'" ~L1996 Ile 145 Ile Leu Asp Ala His 225 His His Phe Phe Pro Lys Phe 210 Tyr Val Leu Asp Leu Leu Asp 195 Phe Phe Leu Leu Ala Phe Val 180 Ser Leu Trp Lys Met 260 Lys Trp 165 Val Ser Ile Val Trp 245 Ser Arg phe Phe Leu Phe 215 Lou Ser Tyr Asp Giy Asp His 200 Thr Trp Thr dly TIyr Thr Ile 185 Val Ile Val1 Leu Ser 265 Ala Thr 170 Lys Leu Pro Phe Phe 250 Arg 1397 His Phe 155 Lou Val Ile Gin Arg Trp Thr Asn 220 Ph. Thr 235 Met Cys Phe Pro Gly Leu Phe 190 Gly Val Val Thr Cys 270 Lys Glu 160 Ph. Aia 175 Phe Glu Thr Tyr Phe Lys Ser Trp 240 Asn Pro 255 Gly Ph.
INFORMATION FOR SEQ ID NO:1861: SEQUENCE CHARACTERISTICS: LENGTH: 249 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_f-eature LOCATION I1.. .249 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1861 Val 1 Leu Thr Gin Lys Thr I16 Leu Lys Ala 145 G iu Arg -iy Ser A.rg Leu Lou Val Lys Thr G ly 130 Phe Glu VTal Val Met Ile Lys Lys Thr Leu Ala Ser Val Leu
L
1 Lou Sen Gin Val Lou Tyr Leu 115 *Val *Thr Ser Lou M4et Val Sen Lys An Thr 100 Ile Lys Lou Val Val Ser Lys Tyr) Asp Thr Pro Pro Ile Lys Lou 165 Ala 10 lai ryn Lys Lys 70 Phe Giu Gly Phe Thr 'Sc LeL Lys Lou His Met 55 Lys Asp Thr Ala Tyr 135 Lou Lys Asp Asn Ala LYS C 25 Gin Gin Ser1 40 Ala Lys Met Pro Ala Val Tyr Ala Gly' 90 Trp, Asp Lys 105 Lou Asp Ph.
120 Ile Ser Asn Lys Sen Phe Giu Lys Gly 170 iu cysnVal Sen P kla Giu Ile Arg kla Lou Asp Asn Ile Lou Asp Lou 7S Tyr Lou Vai LYS Pho Giu Lys Giu' 110 Lou Giu Tyr Ala 125 Arg Thr Gin Lys 140 Lys Lou Pro Gin 155 Lys Pro Lys Ala Val Lou Gin Val 190 Lys Asp Ala LYS 205 Ala Gin Lys Phe ,ou Gly 'no Ile lia Lou ksn Lou ksp Giu Asn Cys Giy Ser Asn Son Asn Lys Val Ser 160 Vai Arg 175 Tyr Glu 180 Thr Lou His Asp 195 UGin Glu Gin Gin /VTr Phe Asp Ala Ile 200 Ala Lys Val Lou 185 Phe Gin Ala Asn Asn Gly Ser Thr II 2 199 6 1388 210 215 220 Giu Trp Ile Ile Lou Pro Asn Ser Leu Tyr Gly Thr 225 230 235 Pro Ile Lys Ala Trp Gin Asn Lys Lys 245 INFORMATION FOR SEQ ID NO:1862: SEQUENCE CHARACTERISTICS: LENGTH: 363 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc feature LOCATION .363 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1862 Trp Glu Asp Gly 240 His A Phe G Val I Leu Leu C Pro Pro Lys Leu Arg 145 Asp Leu Ile Val Phe 225 Ile Lys Asp sp L lu P le P 3 Ile ;ly N ?he .ys 'Asn Ala 130 Gin Lou Lys Ile His 210 Ile Leu Glu Leu ,ys sp rg la Val Ile Asn Ala 115 Pro Asn 114 Lys Al 19 Me G1 I1 Va Al Lys P
C
Lou Asn I Leu Val Asp Arg 100 Lys Lys Arg His Ile 180 L Ser 5 t His 1 Leou e Cys 1 Pro 260 a Lys he Asp Lou Leu Gly Gly Val Met A Lys Asp Lys Val ilu Ser Leu Thr Ser Ala 165 Ala Lys Sex Ile
G
24 Ph Le Cys Lys I His Pro 70 Val Thr Ala Lys Leou 150 Ph& Trp Leou Gly Ala 230 y Pro e Ala u Cys Lys Leu Ala 55 Ser Ile Asp Phe Ile 135 Cys Cys Lys Asr Gl1 215 Ii Gi Hi Al Asp L 2 Gly A 40 Phe I Tyr Ile C Ala Ser 120 Tyr Leu Lys Leu Ala 200 Ser e Leu y Giu s Leu a Asn lys L5 sp eu Thr Gu Leu Leu Ser Lys Asp Lys 185 Asn Ser His Arg Ty 26 Le Glu A Phe I Giu L Thr P Asp A 90 Ile I Arg Trp Thr Tyr 170 Asp Val Pro Glu Lys 250 r Asp 5 .a Sen sn le lys ro 6sn Phe Lys Leu 31u 155 Asp Lys Asp Val Lys 235 Ala Thi Va Ser G Leu V 4 Gly v Ile I His I Leu I Ser Tyr 140 Tyr Leu Ser Lou Leu 220 Leu Thr Ser l Cys sp Phe Val G In Lys Val P al Ile Pro A al Giu Val T la Leou Glu 1 eu Ala Thr he Ser Asn 110 le Pro Tyr In Lys Arg ;lu Tyr Asn ?ro Asn Ala 175 .ys Glu Arg 190 Leu Trp Ile 205 Pro Ala Ser Ser Cys GlU Giu Glu Lou 255 His Ser Lou 270 Ile Gly Asn 285 Gin Ser Ile ly he la Phe '0 Thr ?he Ile Val Leu 160 Gin Ser Gly His Ile 240 Lou Val Ala Gly 275 Gly 290 Pro Leu His Val Ala Lou Phe Asp I ~J91~2 PdL~.$ Gi5~ 996 1389 Phe Tyr Pro Asn Giu Leu Thr Ala Ser Ile Ala Arg Trp Arg Pro Ph.
305 310 315 320 Asn Giu Gin Phe Lou Gly Ile Thr Pro Pro Asn Gly Ser Asn Asp Met 325 330 335 Gly Leu Ile Asp Ilie Gin Lys Giu Ser Glu Lys Ile Met Giy Phe Ile 340 345 350 Thr Lys Asn Leu Ser His His Met Gin Glu Arg 355 360 INFORMATION FOR SEQ ID NO:1863: SEQUENCE CHARACTERISTICS: LENGTH: 662 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pyiori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .662 (xi) SEQUENCE DESCRIPTION: SEQ, ID NO:i863 Gly Asn Thr Ile Ile Lys Met Gin Lys Ser Lou Ile Thr Thr Pro Ile 1 5 10 Tyr Tyr Vai Asn Asp Ile Pro His Ile Giy His Ala Tyr Thr Thr Leu 25 Ile Ala Asp Thr Leu Lys Lys Tyr Tyr Thr Leu Gin Gly Giu Giu Val 40 Ph. Phe Leu Thr Gly Thr Asp Giu His Gly Gin Lys Ile Giu Gin Ser so 55 Ala Arg Lou Arg Asn Gin Ser Pro Lys Ala Tyr Ala Asp Ser Ile Ser 70 75 Ala Ile Ph. Lys Asn Gin Trp Asp Phe Phe Asn Lou Asp Tyr Asp Gly 90 Ph. Ilie Arg Thr Thr Asp Ser Giu His Gin Lys Cys V-al Gin Asn Ala 100 105 110 Phe Glu Ile Met Ph. Giu Lys Gly Asp Ile Tyr Lys Giy Thr Tyr Ser 115 120 125 Gly'Tyr Tyr Cys Val Ser Cys Giu Ser Tyr Cys Ala Val 5cr Lys Val 130 135 140 Asp Asn Thr Asp Ser Lys Val Leu Cys Pro Asp Cys Leu Arg Giu Thr 145 iSO 155 160 Thr Leu Leu Giu Giu Giu Ser Tyr Ph. Ph. Lys Lou Ser Ala Tyr Giu 165 170 175 Lys Pro Lou Lou Glu Ph. Tyr Ala Lys Asn Pro Glu Ala Ile Lou Pro 180 185 190 Ile Tyr Arg Lye Asn Glu Val Thr Ser Ph. Ile Glu Gin Gly Lou Lou 195 200 205 Asp Lou Ser Ile Thr Arg Thr Ser Ph. Giu Trp Gly Ile Pro Leu Pro 210 215 220 Lys Lys Met Asn Asp Pro Lys His Val Val Tyr Val Trp Leu Asp Ala 225 230 235 240 Leu Leu Asn Tyr Aia Ser Aia Leu Gly Tyr Leu Asn Gly Lou Asp Asn 245 250 255 Ls Met Ala His Phe Giu Arg Ala Arg His Ile Val Gly Lys Asp Ile FA//260 265 270 LuArg Ph. His Ala Ile Tyr Trp Pro Ala Ph. Lou Met Ser Lou Asn AI~T O'/ IPEA/Lo 9 /091 2.
i -996 1390 275 Leu pro Leu 280 Cys Phe Lys Gin Leu Val His Gly Gly 305 LOu Glu GiU Arg Thr 385 Ile Ala Ala Leu Phe 465 Ala Ala Ser Lys Glu 545 Asr ArS Gl Pr 290 Val Ala Val Arg Leu 370 Lys Leu Leu Lys Glu 450 Leu Phe Lys Lys Ile 530 Lys Phe Ile 1 Asn o Giu Lys 4et Pro Ile 355 Leu Ile Asp Glu Glu 435 Ala Leu Arg Lys Ile 515 Giu Glu Lys Gl Arg 59 Se Met GiU Phe 340 Asn Gly Thr Asn.
Giu 420 Glu Leu Tyr Val Leu 500 Glu Lys Lys Lys Lys 580 iLou Ser Tyr 325 Gly Ala Met Ala Ala 405 Leu Pro Leu Ala Giu 485 Gin Lys Gly Ala Val 565 Ser Arg Lys 310 2ly Gln Asn Ala Tyr 390 Asn Phe Trp Ser Phe 470 Ile Asp Ile Glu Pro 550 Giu Asn Gir Ser Leu C Ile Glu Asp Gly Leu Asn 360 Lys Lys 375 Tyr Pro Ser Phe Asn Ile Val Leu 440 Leu Ile 455 Met Pro Thr Pro Met Val Glu Lys 520 Giu Ala 535 Pro Thr Ile Lys Lys Leu Ile Ile 600 Gly ;Gu Asp 345 Asn ryr Lys Val Tyr 425 His Ala Lys Asn Leu 505 Ile Leu Gin Val Leu 585 Ser Val Asn Leu 330 Phe Asp Phe Glu Pro 410 Asp Lys Asn Ser Asn 490 Gin Glu Ala Giu Giy 570 Arg Gly Cys Val 315 Arg Ser Leu Asn Leu 395 Lys Phe Asn Thr Ala 475 Tyr Asp Lys Giu Asn S55 Leu Leu Ile Val rrp 300 Leu Tyr Lys Gly Tyr 380 Glu Met Leu Asn Leu 460 Met Giu Thr Ile Lys 540 Tyr Ile Lys Ala Val 285 Trp Asp Phe I Lys 1 Asn 365 Ser Lys Gin Asn Giu 445 Leu Lys Arg Glu Giu 525 Ala Ile Lys Val Leu 605 Ala .hr Ala Leu Ala sjo Leu Lys 430 Ser Gln Leu Phe Pro 510 Lys Glu Ser Giu Asp 590 Asp Asn Ile C Gl i Leu 2 335 Leu I Leu Lys His His 415 Leu Glu Ser Ala Phe 495 Leu Ile Lys Ile Ala 575 Leou Tyr Leu G1u ,ys 120 Arg a 1 Asn Ser 1n Lys Ile Lys Ser Ser 480 Lys Phe Glu Lys Glu 560 Gin Gly Glu Lys 5 r Leu Val Gly Gin Met 615 620 610 f Pro 625 Arg Ala Ala Lys Lou Met Gly Giu Met Ser Giu Gly Met Ile Lou 630 635 Ala Val 640 Lye Ile 655 Asp Asn Asp Asn Leu 645 Gly Ser Leu Ile Ser 660 Ala Leu Ile Pro Thr Arg Glu INFORMATION FOR SEQ ID NO:1864: SEQUENCE CHARACTERISTICS: LENGTH: 342 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (2 4-
C.,
~NT
POT/US 96 0 91 IPEA/NUL.- 1' 996 1391 (ix) FEATURE: NAME/KEY: miscfeature LOCATION 1...342 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1864 Gly 1 Val Phe Ser Ile Ser Ile Leu Pro Thr 145 Glu Leu Thr Gly Phe 225 Ile Met Thr Ser Ala Arg Leu Ser Lys Lys Ile Ser Gly Ser 130 Asp Tyr Ser His Ser 210 Met Gly Gly Asp Val 290 Ile Met Pro Val Glu Met Tyr Ala Arg 115 Val Cys Ala Asn Lys 195 Asp Gly Ser Ala Tyr 275 Ile Tyr Met Lys Ile Val Ile Ile Val Leu Glu Leu Gly 100 Ile Gly Lys Lys Gly 180 Met Ile Asn Ile Leu 260 Ala Ile Gir 5 Ile Leu Ala Glu Gly His Lys Lys Pro Ser 165 Glu Leu Phe Val Phe 245 Met Glu Ser 31u Val Ser Ala 70 Met Ser Gly Arg Glu 150 Val Glu Lys Lys Val 230 Lys Leu Tyr His Gly Gly I Lys 55 Ala Asp Gly Val Pro 135 Tyr Leu Asp Ala Gly 215 Leu Asp Lys Gly Gly Val Asp 40 Val Thr Ile Ala Glu 120 Ser Leu His Ile Tyr 200 Val Lys Glu Asn Gly 280 Lys Asp I Ser 25 Lys Glu Glu Leu Thr 105 Arg Val Ile Tyr Lys 185 Asp Val Thr Ile Ala 265 Ala Ser Leu Met Gly.Ala I 10 Arg Ala Leu Glu 3 Asp Lys Ala Thr I Met Ile His Thr C Ala Ile Lys Arg I 75 Lys Asn Gly Ala Met Gly Leu Ala Pro Ala Ile Cys 125 Leu Leu Asp Ala 140 Asp Phe Ala Leu 155 Asp Ser Prq Lys 170 Gly Asn Thr Leu Phe Phe Tyr Gly 205 Asp Val Val Val 220 Thr Glu Gly Val 235 Lys Ser Ser Phe 250 Phe Gly Ile Leu Pro Leu Leu Gly 285 Asn Ala Arg Ala 300 Glu Ser Gln Val 315 Ser Gln Ser Phe 330 sp Asn I Pro ;1n 7 Lys C Asp Thr I 110 Lhr I ;ly Met Val Val 190 Asn Cys Ala Lys Lys 270 Val Val Cys Glu [is .5 Lys Phe Asp ;1u kla Leu Leu Ala Gly Gly 175 Lys Val Asp Ser Ser 255 Gin Asn Glu Leu Gly Ser Ile Tyr Ser Leu Arg Met Asn Tyr 160 Leu Glu Glu Gly Ala 240 Lys Lys Lys Cys i Arg 320 k 295 Ala Ile Ser Ala Val 310 Ser Leu Lys Ile Thr Gin Ala Phe Glu 325 Ser Asp Gin Gln Asp Ala 340 Ser Gin 335 INFORMATION FOR SEQ ID NO:1865: SEQUENCE CHARACTERISTICS: LENGTH: 253 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori PCT LS 96/091ZZ ~3 1996 1392 (ix) FE.ATURE: NAME/KEY: misc_feature LOCATION .253 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1865 Asn Ala His Ala Phe Thr His Pro Phe Ser Ala Pro Ala Arg Phe Arg 1 5 10 Leu Ala Gin Lys Arg Lys Asp Asn Thr Leu Pro Phe Leu Arg Pro Asp 25 Gly Lys Ser Gin Val Ser Val Arg Tyr Glu Asn Asn Lys Pro Val Ser 40 Val Asp Thr Ile Val Ilie Ser Thr Gin His Ser Pro Giu Val Ser Gin 55 Lys His Leu Lys Glu Ala Val Ile G1u Giu Ile Val Tyr Lys Val Lou 70 75 Pro Lys Giu Tyr Leu His Asp Asn Ile Lys Phe Ph Ile Asn Pro Thr 90 Gly Lys Ph. Val Ilie Gly Gly Pro Gin Gly Asp Ala Giy Leu Thr Giy 100 105 110 Arg Lys Ile Ile Trp Asp Thr Tyr Gly Gly Phe Cys Pro His Gly Giy 115 120 125 Gly Ala Ph. Thr Gly Lys Asp Pro Tyr Lys Val Asp Met Ser Ala Ala 130 135 140 Tyr Ala Ala Arg Tyr Val Ala Lye Asn Lou Val Ala Ser Gly Val Cys 145 150 155 160 Asp Lys Ala Thr Val Gin Leu Ala Tyr Ala Ile Gly Val Ile Giu Pro 165 170 175 Val Ser Ile Tyr Val Asn Thr His Asn Thr Ser Lys His Ser Ser Ala 180 185 190 Giu Lou Glu Lys Cys Val Lys Ser Val Phe Lys Lou Thr Pro Lys Gly 195 200 205 Ile Ile Glu Ser Leu Asp Lou Leu Arg Pro Ile Tyr Ser Lou Thr Ser 210 215 220 Ala Tyr Gly His Ph. Gly Arg Glu Lou Glu Glu Ph. Thr Trp Glu Lys 225 230 235 240 Thr Asn Lys Val Glu Glu Ile Lys Ala Phe Ph. Lys Arg 245 250 INFORMATION FOR SEQ ID NO:1866: SEQUENCE
CHARACTERISTICS:
LENGTH: 145 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc..feature LOCATION .145 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:186 6 Ser Thr Ile His Lys Giu Ph. Lys Leu Lys Gin Arg Thr Lou Ser Ile 1 S 10 Ile Lye Pro Asp Ala Lou Lye Lye Lys Val Val Gly Lye Thr Ile Asp 25 POUS 961091?a C 19 96 Arg Leu Pro Val Met Asp Leu Ph.
145 Phe Ser so Phe Met Gly Phe Glu 130 Giu Val1 Phe Val1 Ala Ala 115 Asn Ser Asn Gly Lys Lys Leu Thr 100 Giu Ala Asp Asp Giu 85 Asp Ser His Ala Lou 70 Gly Pro Ile Asn Leu GlU 55 Ile Lys Lys Asp Glu 135 Giu 40 Asn Glu Asp Leu Ala 120 Ile Val1 Tyr Met Val1 90 Gin Ala Phe 1393 Ala Met Ala Ile 60 Val Ser 75 Aia Lys Lys Gly Val His Phe Phe 140 Lys Arg 45 Leu Arg Gly Pro Asn Arg Thr Ile 110 Gly Ser 125 Ala Ala Lou Gill Val Giu Arg Asp Arg His Arg Val Lou Ala Ser Glu INFORMATION FOR SEQ ID NO:i86 7 SEQUENCE
CHARACTERISTICS:
LENGTH: 193 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori~ (ix) FEATURE: NAME/ KEY misc-featlre LOCATION 193 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:18 67 Gly Lell Phe Ph.
Leu Lys Cys Tyr Phe Arg Ser Pro Lys Asn Ala Ala Lys Phe Gly Asn Ser Ii.
Ala Pro Ph.
Ala 115 Pro Le Gly I Ala 1 Ph.
Asp Leu An Lou 100 His Val Cys Pro Asn 180 Tyr Ile Giu eU [is eu Phe Ile Asp Glu Asn Asp Val 165 G lu Sor Gin Ser met 70 Cys An Leu Phe Let 'Sc Asr Ar~ Arg N~ Lys Glu 55 Arg Ile Asp Val Tyr 135 Giu iLys ;Val tal Ser 40 Ph.
Ser Ala Ser Gly 120 Leu Ile Pro Ala His Gly Arg ValI 10 Ph. Gly Ser .Val 2 25 Ile Asn Ala Leu Giu Pro Lou Glu Lou Lys Lys Glu 75 Pro Cys Asp Ala 90 Ala Lou Gin Ile 105 Glu Ile Asn Pro Ser Pro Lys Asp 140 Leu Giu Ala Arg 155 Ser Leu His Lys 170 Leu Val Ala Lys 185 ,ys Met Val Ala ~la Gly Tyr Lys L'yr Val Lys Ile Is 'sn Tyr Lys Ser Arg Pro Phe Asp Lou Ile Thr Glu Lys Gly Met Pro 110 Lou Ser Pro Ser 125 Tyr His His Ty Tyr Ph. Ala Gly 160 Asn Lys Asn Leu 175 Asp Asp Ser Arg 190 130 His 145 Lys Phe Gin Ala Leu Val I
L-
Ti r9 /0912.
996 1394 INFORMATION FOR SEQ ID NO:1868: SEQUENCE CHARACTERISTICS: LENGTH: 240 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...240 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1868 Asn His Asn Lys Gly Ala Glu Ile Ser Leu Trp Gly Leu Thr Arg Leu 1 5 10 Val Asp Arg Asp Ile Asp Lys Asp Asn Pro Arg Thr Lys Asn Arg Pro 25 Ser Val Asp Gly Arg Ile Ser Val Lys Gly Met Val Ile Phe Ser Val 40 Ser Asn Ala Ile Leu Phe Val Gly Trp Ser Asn Phe Ile Asn Pro Leu 55 Ala Phe Lys Leu Ser Leu Pro Phe Leu Ile Ile Leu Gly Gly Tyr Ser 70 75 Tyr Phe Lys Arg Phe Ser Ser Leu Ala His Phe Val Val Gly Leu Ala 90 Leu Gly Leu Ala Pro Ile Ala Gly Ser Val Ala Val Leu Gly Asp Ile 100 105 110 Pro Leu Trp Asn Val Phe Leu Ala Leu Gly Val Met Leu Trp Val Ala 115 120 125 Gly Phe Asp Leu Leu Tyr Ser Leu Gin Asp Met Glu Phe Asp Lys Glu 130 135 140 Arg Gly Leu Phe Ser Ile Pro Ser Gin Leu Gly Glu Lys Trp Cys Leu 145 150 155 160 Asn Leu Ser Arg Leu Ser His Leu Val Ala Leu Ile Cys Trp Leu Cys 165 170 175 Phe Val Lys Cys Tyr His Gly Gly Leu Phe Ala Tyr Leu Gly Leu Gly 180 185 190 Val Ser Ala Leu Ile Leu Leu Tyr Glu Gln Ile Leu Val Ala Arg Asp 195 200 205 Tyr Lys Asn Ile Pro Lys Ala Phe Phe Val Ser Asn Gly Tyr Leu Gly 210 215 220 Val Val Phe Phe Ile Phe Ile Val Leu Asp Val Gly Phe Lys His Ala 225 230 235 240 INFORMATION FOR SEQ ID NO:1869: SEQUENCE CHARACTERISTICS: LENGTH: 184 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein S.AL (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL
SOURCE:
itSrt 9 £1091 1395 ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...184 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1869 Val 1 Trp Phe Phe Trp Thr Ser Ile Ile Leu 145 Arg Ser Met Gly Glu Ile Leu Leu Leu Ile Ala 130 Ala Met Glu Ala Ile Trp 5 Ser Ser Met Thr Arg Leu Ser Lys Thr Asn Ser Gly Glu Leu Leu Leu Leu Lys 100 Ala Leu Gly 115 Pro Gln Thr Phe Phe Gly His Ala Leu 165 Arg Lys Gly 180 Gly Trp Cys His Glu Leu Val Gln Cys 40 Lys Arg Ser 55 Phe Asp Phe 70 Lys Ala Leu Glu Asn Leu His Gly Leu 120 Tyr Tyr Gly 135 Val Ala Arg 150 Asp Ile Lys Leu Lys Leu Phe Val Asp Leu Ser Tyr Leu 105 Val Arg Asp Arg Leu Phe Leu Leu Arg Ser Leu Ser Phe Ala Val Leu Arg Leu Asn 75 Phe Lys Leu Glu Leu Glu Cys Leu Lys Cys Val Leu 140 Lys Asp Phe 155 Tyr Asp Ser 170 Ser Gin Ser Glu Val Glu Gin Lys 125 Glu Leu Phe Met Gly Arg Asp Asp Glu Arg Leu Ile Thr 16A Asp INFORMATION FOR SEQ ID NO:1870: SEQUENCE CHARACTERISTICS: LENGTH: 115 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION 1...115 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1870 Thr Gly Ala Ile Met Leu Ser Ser Asn Asp Leu Phe Met 1 5 10 Gly Ala Ile Leu Leu Val Leu Val Cys Leu Val Gly Tyr 25 Lys Glu Lys Glu Phe Tyr His Lys Met Arg Arg Leu Glu 40 Asp G1u Ser Tyr Gln Glu Asn Tyr Leu Tyr Ser Lys Arg 55 Leu Glu Gly Arg Leu G1u Gly Leu Ser Leu Glu Lys Ser 70 75 Asp Ser Ser Leu Lys Thr Thr Leu Ser His Leu Tyr Asn Val Leu Lys Leu Ala Gin Val Tyr Thr Arg Lys Leu Leu Leu Leu Glu Glu Gin
X§~NT
PCT/US 96/09122.
iPE L3 I6DEC1996 1396 90 Glu Ile Gln Lys Ser Met Asp Lys Glu Arg Asp Tyr Leu Glu Glu Lys 100 105 110 Ile Ile Thr 115 INFORMATION FOR SEQ ID NO:1871: SEQUENCE CHARACTERISTICS: LENGTH: 335 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...335 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1871 Glu 1 Arg Phe Glu Leu Ala Met Trp Ile Glu 145 Pro Ile Asp Lys Asp 225 Gin Thr Glu Pro Ser Phe Glu Glu Thr Met Val Lys 130 Arg Asn Phe Pro Ile 210 Phe Ile Prc Asp Ile His Thr Ile Leu Gly Gly Pro 115 Thr Glu Asn SGin Gin 195 Lys Gl1u Lei.
Thi Va Lys Ser 3 5 Glu Ile Lys Glu Tyr Gly Gly Gu Val Gin Glu Asn 100 Leu Glu Tyr Leu Val Tyr SII Gin 165 Ile Phe 180 Gin Leu Phe Gly Glu Gly Ile Ser 245 Leu Thr 260 i Ser Ala Asp Gin Leu Ala Asp 70 Leu Ser Asn Arg Tyr 150 Gly Leu Ala Val Lys 230 Tyr Arg Asp Lys Glu Ala Phe Gly Asp Phe 55 Asp Lys Asp Trp Ile 135 Ala Leu Asp Asn Ala 215 Leu Phe Val Ala As: 29' Val Ser 1 25 Asn Tyr 40 Leu Trp 1 Pro Gn Gly Leu Asn Gn 105 Leu Gly 120 Tyr Phe Leu Lys Met Ser Arg Asp 185 Leu Arg 200 Lys Pro Asp Tyr Val Arg Leu Tyr 265 Leu Lys 280 i Asp Asp 5 10 His Ile Leu Val Asp 90 Asn Glu Glu Ala Asp 170 His Leu Phe Gil Arg 25( Ser Ar< Lys Asp L Ile L Ser L Lys I
E
Val I 75 Leu I Arg I Lys I Asp His 155 Met Tyr Arg Val Asn 235 Ser r Leu Tyr s Ile eu Val Met C
I
ys ,ys le 0 >he Ile jeu Asp Arg 140 His Arg Phe Val Leu 220 Phe Val Tyr Leu.
Lys 30( Asn Asn Gly Tyr Val Ala I Glu Ser Arg Asn Tyr Asn 110 Leu Asn 125 Val Lys Arg Asp Glu Tyr Leu His 190 Lys Asp 205 Arg Cys His Glu Cys Gly Arg Gin 270 Gly Lys 285 Ala Ala 1 ;ln Tyr Arg Ile Ile Tyr rhr Asp Glu Asn Gly 175 Arg Leu Ala Ile Asp 255 Leu Se Ph.
Ash Ain Lys Ile Gly Asn Leu Tyr Phe Gly Phe 160 Arg Gly Val Arg Leu 240 Ser Gly r Val e Leu 275 Gly Gin 290 Met Ala Phe Prc r POT/US 9 6 09122.
iPEA/ 1 DEC1996 1397 Val Arg Asn Ala Tyr Ala Ala Asn Gin Val Cys Lys Phe Ile Leu Leu 305 310 315 320 Glu Ile Glu Lys Leu Ala Thr Leu Asn Arg Gin Lys Lys Arg Ile 325 330 335 INFORMATION FOR SEQ ID NO:1872: SEQUENCE CHARACTERISTICS: LENGTH: 94 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...94 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1872 Phe Tyr Val Ser Ile Ile Lys Cys Thr Pro Leu Leu Val Gin Ile Val 1 5 10 lile Val Phe Tyr Gly Leu Pro Ala Leu Gly Val Tyr Met Asp Pro Ile- 25 Pro Ala Gly Ile lie Ala Phe Ser Phe Asn Val Gly Ala Tyr Ala Ser 40 Glu Thr Leu Arg Ala Ser Phe Leu Ser Val Pro Lys Asp Gin Trp Asp 55 Ser Ser Leu Ser Leu Gly Leu Asn Tyr Leu Gln'Thr Pre Trp His Val 70 75 lie Phe Phe Gin Ala Leu Lys Val Ala Thr Ala Lys Pro Lys INFORMATION FOR SEQ ID NO:1873: SEQUENCE CHARACTERISTICS: LENGTH: 461 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...461 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1873 Ser Ile Lys His Leu Gly Lys Lys Glu Val Lys Thr Leu Gly Leu Ser 1 5 10 Ser Leu Gly Gly Thr Leu Glu Phe Tyr Asp Phe Ile Ile Phe Val Phe RA' 20 25 Phe Thr Ser Ile Ile Ala Lys His Phe Phe Pro Asn Thr Leu Ser Pro A o S;° POT/US 9 6 /091 P~A~'b id~zi1996 1398 Ile Trp Ser Glu Ile Asn Ala Arg P Gly Arg I Thr Phe Gly Val Tyr Ile 130 Ala Val 145 Ala Pro Val Val Met Val Phe Gly 210 Phe Leu 225 Leu Val Ile Ser Ile Phe His Phe 290 Gly Ile 305 Lys Pro Gly Phe Asn Thr Asn Phe 370 Phe Ser 385 Gly Phe Val Pro Val Ser His Lys 450 Pro Lys la Asp Lis Ala Gly ;Gn Ser Phe 195 Leu Glu Lys Ile Ile 275 Thr Val His Leu Ile 355 Cys Thi Gl Le 43 Leu C Asn b Leu 100 Ser b Pro Gly Gly Gly 180 Asp Gly Giu Phe Ser 260 Leu Pro Ser Lys Phe 340 Ile Pro Ile Pro i Ser 420 .I Ile 5 ly C Met la I Met Val ;Gu ;in 165 Ile Lys Gly Thr Pro 245 Met Phe Phe Ser Val 325 Phe Leou Ile Ser Gin 405 Leou Gly 70 Phe Leu ly ?he Leu L50 Lys Leu Pro Ile Pro 230 Leu Leu Val Glu Ile 310 Cys Lys Tyr Phe Ph 39( Le G1 40 Thr Tyr G 55 Ile Val M Met Leu S Met Pro T 1 Leu Thr P 120 Leu Val L 135 Pro Gly P Asn Thr T Leu Gly E Val Val C 200 Phe Gly 215 Val Phe Lys Giu Ile Thr Pro Asn 280 Lys Thr 295 Ile Phe Met Ala Glu Phe Phe Leu 360 Met Ser 375 e Ala Tyr 1 Ser Ser n Ser Tyr ly et er 'hr 05 ro eu la lyr er 185 Giu Ile ;in Val rrp 265 Phe Tyr Thr Phe Tyr 345 Ala Asp Asr Trp Gl 42 Ile P Ala H Ile L 90 Phe Lys Val Trp Ile C 170 Leu Asp Ile Gin Phe 250 Val Thr Phe Gly Ser 330 Ser Cys Val Ile Leu 410 y Leu he is eu Asn Asn Arg tal L55 Gly Val Trp Ser Met 235 Lys Leu Leu Gin Phe 31S Ala Asn Phe Phe Ala 39' As So Ala Ala Gly T Phe Gly Asp L Leu Met Val I 9 Asp Leu Val G 110 Ala His Tyr L 125 Ile Cys Gin G 140 Phe Val His G Phe Leu Thr A 1 Tyr Ile Gly I 190 Ala Trp Arg V 205 Val Tyr Leu 220 Lys Gin Asp Asn Ser Leu Thr Ala Cys 270 Thr His Pro 285 Ile Leu Gly 300 Leu Ala Asp Ala Phe Gly Ala Pro Ser 350 Cys Ala Gly 365 Ser Ala Arg 380 Tyr Ala Ile i Ala Lys Ala r Phe Tyr Ile yr ys le 5 ly eu ly lu la .75 le al rg Asp ?he 255 Ile Asn Leu Lys Phe 335 Leu Ile
ILE
Th 11 41 Le Leu Phe Pro Phe Gly Val His 160 Ser Tyr Ala Arg Ala 240 Gly Let Phe Val Ile 320 Phe Val Met Arg Ala 400 e Ala u Ile 430 Pro Ile Tyr Ala Phe Ile Thr Ser Leu Leu Met 440 Glu Val Ser Pro Ala 445 Ala Ser Asn Thr Gin His 455 Thr 460 INFORMATION FOR SEQ ID NO:1874: SEQUENCE CHARACTERISTICS: LENGTH: 507 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
POT/US 96/0912.2.
IPE~MJ 18DEC1996 1399 (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .507 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1874 Lys S 1 Tyr S Asp P Gly A Gly S Val L Glu T Ser I Leu Asn C 145 His I Gly Asp Arg Leu 225 Asn Val Leu Asp Ser 305 Ala Lys Ala Ile er Leu Lys er he Lrg 0 er eu yr Ile Lys Glu Asp Ser Asp Leu 210 Lys Ala Gly Ala Met 290 Pro Ile Ala Thi Let 37( Leu A 2 Glu I Ile I Ser A Thr P Arg S Val 115 Asn Ser Lys Arg Val 195 Asn Asn Ile Ser Lys 275 Ser Ser Lys His Leu 355 Ile sp :0 ys le sn sp er 100 Asn Ile Val ?he Lys 180 Gin Ser Lys Lys Phe 260 Glu.
Glt Gi Ly Pr 34 Se Me Lys L 5 Leu A Arg L Leu P Ala C Gly Val I Val C Ala Phe Leu 165 Lys Glu Asp Ile Ile 245 Lou Lau Tyr Tyr s His 325 o Asn 0 r Asp t Thr ys la eu he ly Ser Phe Glu ro Lys 150 Pro Ile Thr Lys Phe 230 Gln Phe Ala Lys Val 310 Prc Va.
As Se
C
Leu Lys Ile 55 Ser Leu Glu Giu Leu 135 Ala Asp Asn Lou Lys 215 Ala His Val Lau Glu 295 Gly His L Ty n Le r As 37 10 Met Val Ala C 25 Lys Thr Leu 40 Asp Glu Il Leu Asp Ala Lys Cys Leu 90 Lys Asp Lys 105 Pro Ser Lys 120 Tyr Glu Glu Cys Val Asp Lys Ala Ile 170 Pro Lys Lys 185 Ala Leu Lys 200 Ala Lou Lou Gin Thr Glu Cys Gly Lou 250 Gly Pro Ser 265 Asn Lou Asn 280 Ala His Ser Phe Giu Gin Cys Lou Lou 330 r Asp Lou Lou 345 i Gly Asn Lys 360 n Val Gly Ser 5 ly A Lys G His T 6 Ala A 75 ;ly A Ala P Glu A His H 1 Leu TI 155 Glu L Gly L Lou Arg Ala 235 Ser Gly' Lou Val Gly 315 Leu Lou Ala Lys Asp 395 ys Arg Ser Phe Leu Gin Glu la L lu I 4 hr L 0 sn. I la he I la is 'hr eu 'ys 'ys Asn 220 Ile Ala Val His Ala 300 Gly Leu lys le eu le Thr Asn Cys 125 ;in Ser Leu Lys Ile 205 Lou Asn Lys G1 Ph 28 Ly Le As Tyr Glu Val Tyr Arg Gly Gin Gin Asn Leu Gly Ala Leu Lys Pro Thr Phe Glu Arg Arg Phe 110 Tyr Lou Ile Val Arg Tyr Tyr Tyr Met 160 Asp Glu Val 175 Ile Ser Val 190 Pro Lys Met Glu Lys Ser Leu Val Ser 240 Asn Lys Pro 255 Lys Thr Glu 270 e 5 s .1 p Glu
LOU
Lou Glu Arg Ile Val Ile 335 Phe Gly Asn 320 Glu Gly Phe Phe Ser Thr Lys 390 Asn Ala Lys Tyr Gin Val Met Asp 350 Ser Phe Lys His 365 Asp Lys Asp Thr 380 Arg Ala Val Lys Ala Ile Val Pro 415 Val Ser Val Glu 430 Val Ile Lou Lys Asn Val Lou Glu 400 Phe Leu Phe 3410 Lou Lau Thr Pro Glu Lou Ang Sen Arg Ile Asp Asn Ala Leu Ser 420 Asp Gly Lou Lys Lou Glu Asp Phe Glu 425 Ala Lou Ala Ile Giu 410 Arg Ile Gin Gly PO/US 9 6 /091?2 1PEN/US 18DE C 199 6 1400 His Phe 465 Gin Ser 435 440 Lys Giu Val Val Lys Cys Ile Ala Gin Lys Ser 450 455 460 Gly Ala Arg Glu Ile Lys Lys Ile Ilie Gin Arg 470 475 Leu Ser Asp Ile Val Lou Lys Gin Ser Leu Lys 485 490 Leu Arg Met Lys Ser Thr Phe His Lys Val S00 505 445 Tyr Gin Arg Ser Giu Ile Asn Pro 480 Lys Pro Thr Arg 495 INFORMATION FOR SEQ ID NO:1875: SEQUENCE CHARACTERISTICS: LENGTH: 178 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/ KEY misc...feature LOCATION .178 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1875 Gly Ile Lys Leu Ile Lys Phe Val Arg Asn Val Val Lou Phe Ilie Leu 1 5 Thr Ala Ilie Phe Leu His Tyr Ser Vai Ala Giu Asn Giu Asn Thr so Asp Val Tyr Ph. Val Thr Val Tyr Arg Asn Lys Ph. Asn Ser Ala 100 Gin Gin Val Glu Val 115 Met Ph. Pro Asn Val 130 Met Ser Lys Pro Val 145 Gly Ph. Ph. Ile Ser 165 Ala His Ala Val1 Pro Gin 70 Glu Asp Gin 110 Ph.
Phe Ile Asn Thr Asp Ile Tyr Phe 135 Ser Met Son 40 Asn Tyr Thr Ser Tyn 120 Lou Trp Leu 25 Gly Lys Asp Arg Ala 105 Gly Lys Ile Lou Val1 Giu Pro Ph.
90 Leu Trp Pro Lou Val G lu Val1 Lys 75 Gly Ala Ang Lou Tyr Ser Val1 Lys Asp Ph.
Gin Ile Lys 140 Ala Tyr Lys Thr Gin Pro Ser Asn 125 Giu Lou Cys 30 Arg Lou Lys Ph.
Lou 110 Lou Son Lou Iet Met Ala Ser Tyr Val Ph.
Asp Lou Pro Asn Arg Val Ph.
Asn Asn Glu Val 160 150 155 Ala Arg Son Val Cys 170 Thr Lou Ph. Lys Gly Lys 175 INFORMATION FOR SEQ ID NO:1876: SEQUENCE CHARACTERISTICS: LENGTH: 638 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein AM F N D I- P S1 i FIE T FUS 9 6I/09, IPAIS 18 DEC 1996 1401.
(iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .638 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1876 Ala Arg Leu Leu Leu Ty'r Asn Leu Lys Asn Phe Ile Lys Gly Lys Ser 1 5 10 Ser Met Ser Asn Gin Giu Tyr Thr Phe Gin Thr Glu Ile Asn Gin Leu 25 Leu Asp Leu Met Ile His Ser Leu Tyr Ser Asn Lys Giu Ile Phe Leu 40 Arg Giu Leu Ile Ser Asn Ala Ser Asp Aia Leu Asp Lys Leu Asn Tyr 55 Leu Met Leu Thr Asp Giu Lys Leu Lys Gly Leu Asn Thr Thr Pro Ser 70 75 Ilie His Leu Ser Phe Asp Ser Gin Lys Lys Thr Leu Thr Ile Lys Asp 90 Asn Giy Ile Gly Met Asp Lys Ser Asp Leu Ile Giu His Leu Giy Thr 100 105 110 Ile Ala Lys Ser Gly Thr Lys Ser Phe Leu Ser Ala Leu Ser Giy Asp 115 120 125 Lys Lys Lys Asp Ser Ala Leu Ile Gly Gin Phe Gly Val Giy Phe Tyr 130 135 140 Ser Ala Phe Met Val Ala Ser Lys Ile Val Val Gin Thr Lys Lys Vai 145 150 155 160 Thr Ser His Gin Ala Tyr Ala Trp Val Ser Asp Gly Lys Gly Lys Phe 165 170 175 Giu Ile Ser Giu Cys Val Lys Giu Giu Gin Gly Thr Giu Ile Thr Leu 180 185 190 Phe Leu Lys Giu Glu Asp Ser His Phe Ala Ser Arg Trp Giu Ile Asp 195 200 205 Ser Val Vai Lys Lys Tyr Ser Giu His Ile Pro Phe Pro Ile Phe Leu 210 21.5 220 Thr Tyr Thr Asp Thr Lys Phe Giu Gly Glu Gly Asp Asn Lys Lys Giu 225 230 235 240 Val Lys Giu Giu Lys Cys Asp Gin Ile Asn Gin Ala Ser Ala Leu Trp 245 250 255 Lys Met Asn Lys Ser Giu Leu Lys Giu Lys Asp Tyr Lys Asp Phe Tyr 260 265 270 Gin Ser Phe Ala His Asp Asn Ser Giu Pro Leu Ser Tyr Ile His Asn 275 280 285 Lys Val Glu Gly Ser Leu Glu Tyr Thr Thr Leu Phe Tyr Ile Pro Ser 290 295 300 Lys Ala Pro Phe Asp Leu Phe Arg Val Asp Tyr Lys Ser Gly Val Lys 305 310 315 320 Leu Tyr Val Lys Arg Val Phe Ile Thr Asp Asp Asp Lys Giu Leu Leu 325 330 335 Pro Ser Tyr Leu Arg Phe Val Lys Gly Val Ile Asp Ser Giu Asp Leu 340 345 350 Pro Leu Asn Val Ser Arg Giu Ile Leu Gin Gin Asn Lys Ile Leu Ala 355 360 365 Asn Ile Arg Ser Ala Ser Val Lys Lys Ile Leu Ser Glu Ile Giu Arg 370 375 380 Leu Ser Lys Asp Asn Lys Asn Tyr His Lys Phe Tyr Giu Pro Phe Gly 385 390 395 400 Lys Val Leu Lys Giu Gly Leu Tyr Gly Asp Phe Giu Asn Lys Glu Lys A, 405 410 415 \Leu Leu Glu Leu Leu Arg Phe Tyr Ser Lys Asp Lys Gly Glu Trp Ile P iUS 96/09 1 Z IPENUS 1 8DEC1996 1402 420 425 430 Ser Leu Lys Giu Tyr Lys Glu Asn Leu Lys Glu Asn Gln Lys Ser lle 435 440 445 Tyr Tyr Leu Leu Gly Giu Asn Leu Asp Leu Leu Lys Ala Ser Pro Leu 450 455 460 Leu Glu Lys Tyr Ala Gin Lys Gly Tyr Asp Val Leu Leu Leu Ser Asp 465 470 475 480 Glu Ile Asp Ala Phe Val Met Pro Gly Val Asn Glu Tyr Asp Lys Thr 485 490 495 Pro Phe Arg Asp Ala Ser His Ser Glu Ser Leu Lys Glu Leu Gly Leu 500 505 510 Ala Glu Ile His Asp Glu Val Lys Asp Gln Phe Lys Asp Leu Ile Lys 515 520 525 Ala Phe Glu Glu Asn Leu Lys Asp Glu Ile Lys Gly Val Glu Leu Ser 530 535 540 Gly His Leu Thr Ser Ala Val Ala Leu Ile Gly Asp Glu Pro Asn Ala 545 550 555 560 Met Met Ala Asn Trp Met Arg Gin Met Gly Gln Ser Val Pro Glu Ser 565 570 575 Lys Lys Thr Leu Glu Leu Asn Pro Asn His Ala Ile Leu Gln Lys Leu 580 585 590 Leu Lys Cys Glu Asp Lys Glu Gin Leu Ser Ala Phe Ile Trp Leu Leu 595 600 605 Tyr Asp Gly Ala Lys Leu Leu Glu Lys Gly Ala Leu Lys Asp Ala Lys 610 615 620 Ser Phe Asn Glu Arg Leu Asn Ser Val Leu Leu Lys Ala Leu 625 630 635 INFORMATION FOR SEQ ID NO:1877: SEQUENCE CHARACTERISTICS: LENGTH: 425 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...425 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1877 Lys Gln Phe Gly Arg Arg Val Phe Thr Gin Ile Pro Lys Met Val Gin 1 5 10 Phe Gln Asn Thr Leu Ile Lys Phe His Ala Leu Ser Phe Lys Asn Ala 25 Asn Leu Ile Tyr Asn Ala Lys Leu Asn Lys Thr Cys Tyr Lys Glu Asn 40 Ser Asn Thr Ile Ile Leu Arg Ile Lys Met Leu Thr Gin Glu Asp Val 55 Leu Asn Ala Leu Lys Thr Ile Ile Tyr Pro Asn Phe Glu Lys Asp Ile 70 75 Val Ser Phe Gly Phe Val Lys Asn Ile Thr Leu His Asp Asn Gln Leu 90 Gly Leu Leu Ile Glu Ile Pro Ser Ser Ser Glu Glu Thr Ser Ala Ile 100 105 110 ,Leu Arg Glu Asn Ile Ser Lys Ala Met Gln Glu Lys Gly Val Lys Ala 115 120 125 PCT/W 96 091a2 iPENAS 18D E C1996 Leu Thr 145 Ser Ile Val1 Val1 Gly 225 Leu Ser Pro Ser Ala 305 Gly Giu Tyr Leu Val1 385 Leu Pro Asn 130 Thr dly Ala Tyr Ile 210 Val Ile Asp Gly Ala 290 Lys Ilie Ser Asn Gly 370 Ser Asp Thr Leu Lys Lys Leu Gly 195 Met Ser Trp Ile Thr 275 Gly Arg Val1 Giu Thr 355 Gly Ala Lys Gin Asp Asn Gly Ala 180 Pro Asp Val1 Arg Ile 260 Gly Ile Ser Giu Ile 340 Gin Asp Lys Val1 Thr 420 Ile Leu Giy 165 As n As n Pro Met Gly 245 Trp Asp Thr Leu Asn 325 Phe Ile Lys Ile Giu 405 His Lys Ala 150 Val Leu Ile Ser Ser 230 Pro Gly Ala Val1 Asp 310 Met Gly Leu Gly Phe 390 Arg Ala Thr 135 Lys dly Asn Pro Gly 215 Met Met Asp Gin Thr 295 Met Gly Ser Ala Giu 375 Giu Giu Tyr Pro Asn Lys Gin Arg 200 Lys Gly Leu Leu Leu 280 Thr Phe Ser Asn Lys 360 Pro Lys Lys Ser 140 Pro Lys Pro G Ile Lys His V 155 Ser Thr Thr S 170 Lys Val Gly 1 185 Met Met Gly I Lys Leu Ile 1 Leu Leu Tyr 235 Met Arg AlaI 250 Asp Val Leu N 265 Thr Leu Ala Pro Gin Ile Lys Lys Leu 315 Phe Val Cys 330 Ser Met Ser 345 Leu Pro Leu Ile Val Ile Met Ala Lys 395 '3 ,in al1 ~er jeu ~eu ~ro ~sp le al1 ln la 1 ~00 iis ;Au ,1y Glu Ser 380 Asp Ala Val1 Val Leu Gin 205 Leu Glu Giu Val1 Ala 285 Ser Ile His Leu Pro 365 His Leu Pro Met Asn Asp 190 Asn Lys Gly Gin Asp 270 Val1 Leu Pro Cys Leu 350 Lys Pro Ser Lys Ile Leu 175 Ala Ala Ala Gin Met 255 Met Pro Asp Ile Lys 335 Glu Val1 Thr Ala Pro Ser 160 Ser Asp Asp Phe Ser 240 Leu Pro Leu Asp Ala 320 Lys Ala Arg Ser Phe Leu Ala 410 His 425 Asp Asn Lys Asp Ile Gin 415 INFORMATION FOR SEQ ID NO:1878: SEQUENCE CHARACTERISTICS: LENGTH: 443 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .443 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1878 Leu Gly Phe Leu Ala Leu His Gly Phe Phe Leu Sen Ala Phe Giu Tyr 1 5 10 Gin Val Sen Ala Arg Val Gly Ser Phe Ser Ang Ile Ala Phe Asn Gin 20 25 Ser Ile Ile Asn Sen Lys Lys Gly Ile Tyr Pro Thr Gly Sen Tyr Val <~RAj NT 01 ill 1/ PCT/US v /09 12 iPtAAiUS 18DEC1996 1404 Thr Ile Leu Ala Tyr Asn Lys 145 Phe Lys Glu Ile Ile 225 Pro Trp Tyr Ala Gly .3..-05 Trp Pro Ile Tyr Val 385 Val Phe Ser Thr Glu Ala Gly Leu Ala 130 Asp Leu Phe Gin Asn 210 Arg Gly Arg Leu Ala 290 Trp Asn Tyr Asn Gly 370 Thr Asn Thr Tyr Thr Asn Tyr Phe Met 115 Arg Ile Ser Lys Tyr 195 Tyr Ile Phe Ile Ser 275 Leu Ser Gly Glu Ala 355 Lys Phe Gly Ser Leu 435 Gly His Asp Gin 100 Gin Pro Phe Gly Ile 180 Ile Gly Ala Glu Gin 260 Lys Phe Val Ser Asp 340 Phe Leu Lys Tyr Gly 420 Met Ala Lys Ser Pro His Tyr Gly Phe 165 Val Arg Met Pro Ile 245 Thr Asp Val Tyr Pro 325 Ala Ile Thr Tyr Gin 405 Tyr Ser Leu Leu 70 Thr Ala Ser Val Ile 150 Asn Trp Asp His Phe 230 Thr Thr Tyr Phe Lys 310 Ile Tyr Gly Tyr Asn 390 Ile Asn Ser Gin 55 Gly Lys Asn Gin Leu 135 Lys Gin Phe Phe Asn 215 Ile His Phe Tyr Gin 295 Asn Asp Ser Lys Ser 375 Leu Thr Pro Met 40 Val Phe Phe Trp Asn 120 Tyr Leu Gly Ser Tyr 200 Phe Trp Asp Tyr Arg 280 Arg Phe Pro Asn Ser 360 Pro Lys Met Asp Ser 440 Asp Gly Leu Tyr 105 Trp Asn Gly Phe Thr 185 Ala Asn Phe Thr Ala 265 Ala Val Gly Phe Phe 345 Ile Arg Lys His Phe 425 Tyr Ser Val Ile 90 Tyr Thr Leu Arg Glu 170 Phe Pro Leu Tyr Lys 250 Trp Ala Asn Asn Tyr 330 Tyr Lys Ala His Lys 410 Ala Arg Ser Gly 75 Asp Met Arg Tyr Tyr 155 Ile Gly Val Val Pro 235 Ser Phe Leu Phe Ala 315 Asp Asn Asn Asp Ile 395 Gly Gin Phe Leu Gly Glu Gly Glu Leu 140 Pro Phe Arg Asn Tyr 220 Lys Tyr Pro Val Arg 300 Ser Thr Ala Leu Ala 380 Tyr Tyr Thr Leu Pro Glu Ile Ala Asn Arg Trp 110 Gin Lys 125 Asp Tyr Ser Lys Tyr Arg Ala Leu 190 Tyr Lys 205 Glu Asn Asn Phe Trp Lys Leu Tyr 270 Gly Lys 285 Ser Tyr Val Gin Lys Asp Asn Ser 350 Leu Val 365 Gin Ser Phe Met Lys Val Ile Gin 430 Lys Gly Pro Glu Ala Gin Ala Trp 175 Ala Gln Lys Asn Ser 255 Ser Lys Arg Leu Asp 335 Ile Gin Leu Leu Gly 415 Asn Gly Ala Lys Gly Gln Tyr Leu 160 Lys Asn Lys Tyr Ala 240 Leu Asp Ser Phe Gly 320 Thr Thr Leu Gly Met 400 Phe Arg INFORMATION FOR SEQ ID NO:1879: SEQUENCE CHARACTERISTICS: LENGTH: 138 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE:
LIJ
rv uo 9 6 0912 IPEAUS 18 DEC 1996 1405 ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...138 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1879 Tyr Pro Thr Asn Thr Ile Ile Glu Arg Ile Leu Met Phe Lys Lys Met 1 5 10 Cys Leu Ser Leu Leu Met Ile Ser Gly Val Cys Val Gly Ala Lys Asp 25 Leu Asp Phe Lys Leu Asp Tyr Arg Ala Thr Gly Gly Lys Phe Met Gly 40 Lys Met Thr Asp Ser Ser Leu Leu Ser Ile Thr Ser Met Asn Asp Glu 55 Pro Val Val Ile Lys Asn Leu Ile Val Asn Arg Gly Asn Ser Val Glu 70 75 Ala Thr Lys Lys Val Glu Pro Lys Phe Gly Asp Lys Phe Lys Lys Glu 90 Lys Leu Phe Asp His Glu Leu Lys Tyr Ser Gln Gln Ile Phe Tyr Arg 100 105 110 Leu Asp Cys Lys Pro Asn Gln Leu Leu Glu Val Lys Ile Ile Thr Asp 115 120 125 Lys Gly Glu Tyr Tyr His Lys Phe Ser Lys 130 135 INFORMATION FOR SEQ ID NO:1880: SEQUENCE CHARACTERISTICS: LENGTH: 391 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...391 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1880 Arg Ile Gly Met Asp Ala Leu Glu Ile Thr Gln Lys Leu Ile Ser Tyr 1 5 10 Pro Thr Ile Thr Pro Lys Glu Cys Gly Ile Phe Glu Tyr Ile Lys Ser 25 Leu Phe Pro Ala Phe Lys Thr Leu GIu Cys Glu Lys Asn Gly Val Lys 40 Asn Leu Phe Leu Tyr Arg lie Phe Asn Pro Leu Lys Lys His Ala Glu 55 Lys Glu His Ala Lys Glu Lys His Val Lys Glu Asn Val Lys Pro Leu 70 75 His Phe Cys Phe Ala Gly His Ile Asp Val Val Pro Pro Gly Asn Asn 90 Trp Gln Ser Asp Pro Phe Lys Pro Ile Ile Lys Glu Gly Phe Leu Tyr 100 105 110 Gly Arg Gly Ala Gln Asp Met Lys Gly Gly Val Gly Ala Phe Leu Ser 115 120 125 Ala Ser Leu Asn Phe Asn Pro Lys Thr Pro Phe Leu Leu Ser Ile Leu POUS 9 6/O09 1 IPEAIUS 1 8 D EC01996 1406 130 Leu Thr Ser Asp Giu 145 Leu Ala Arg His Ser 225 Cys G ly Arg Lys Ser 305 Giu Gly Val1 Val1 Leu 385 Giu Giu Arg Val1 210 Val Phe Ala His Val 290 Pro Asn Gly Giu Ser 370 Glu Lys Pro Gly 195 Ala Leu Asp Asn Ser 275 Leu Phe Ile Thr Phe 355 Leu Gly Leu Thr 180 Ser Tyr Pro Pro Asn 260 Leu Lys Ile Leu Ser 340 Gly Lys Leu Lys 165 Cys Ile Pro Leu Ser 245 Val1 Lys Asp Thr Lys 325 Asp Ala Giu Ser 135 Giu Gly 150 Giu Lys Glu Lys Asn Gly Gin Lys 215 Ile Ser 230 Lys Leu Thr Pro Thr Thr Leu Pro 295 Ala Ser 310 Thr Cys Ala Arg Ile Asn Leu Giu 375 Giu Lys 390 Pro Asp Val1 Lys 200 Cys Gly Val1 Gly Gin 280 Tyr His His Phe Asp 360 Leu Gly Leu Leu 185 Leu Gin Val1 Ile Ser 265 Giu Thr Ser Thr Phe 345 Arg Leu Ile Leu 170 Gly Ile Asn His Thr 250 Val1 Ser Leu Lys Thr 330 Ser Ile Glu Phe 155 Pro Asp Leu Pro Leu 235 Asn Giu Leu Giu Leu 315 Pro Ala His Lys 140 Gly His Ser Lys Ile 220 Asp Leu Ile Lys Leu 300 Thr Leu His Ala Val1 380 Thr Met Ile Gly 205 Asp As n His Ala G iu 285 Giu Ser Leu Gly Val1 365 Phe Leu Met 160 Ile Val 175 Ile Gly Gin Gly Leu Ala Asp Giu 240 Gly Leu 255 Asn Ala Leu Glu Ser Ser Leu Gin 320 Thr Lys 335 Giu -Val Giu Arg Gly Val INFORMATION FOR SEQ ID NO:1881: SEQUENCE CHARACTERISTICS: LENGTH: 928 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION 928 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:188i Ser Leu Asp His Lys Ile thr Asp Phe Ser Cys Val Asp Leu Arg 10 Gin Ser Lys Giu Val Sen His Asn Leu Lys Giu Leu Ser Lys Thn 25 Sle Ser Tyr Pro Phe Giu Lys His Val Giu Ala Leu Gly Giu Gin 40 iSen Asn Phe Val Sen Ile Pro Ile Asn Asn Asp Asp Tyr Ser Asn 55 SCys Thr Phe Val Ser Asp Phe Ile Asn Leu Ilie Ala Ser Tyr Asn 70 75 Thi Let Cy~ RA/ 65 A 0/ /VTr 0~ AMEE~k".0 SHFE~r Leu Leu Glu Ser Phe Leu Asp Phe Tyr Lys 90 Gil Lys Tyr Tyr 145 Leu Lys Lys Ile Asn 225 Asp Glu Glu Asn Ser 305 Ser Arg Tyr Asn Tyr 385 Ile Lys Ser Phe Trp 465 Asp Lys Ser Asn Phe 545 Lys Val .i Leu Leu Gin 130 Lys Ala Pro Ile Lys 210 Phe Glu Ile Tyr Tyr 290 Met Giu Ser Leu Lys 370 Cys Asn Glu Thr Gin 450 Ile Leu Tyr Lys Asp 530 Aia Ile Gin Asn Val Ile 115 Cys Pro Lys Gin Phe 195 Asp Lys Ile Glu Lys 275 Ile Met Ile Leu Phe 355 Glu Arg Asn Tyr Lys 435 Leu Pro 3Gu Leu Asp 515 Ile Lys Asp Asp Asn Thr 100 Lys Ile Asn Ile Asp 180 Lys Ile Arg Lys Asn 260 Ile Glu Cys Val Trp 340 Pro Lys Glu Gly Lys 420 Glu Ser Leu Ile Gin 500 Phe Leu Gly Ser Ser 580 Lys Glu His Arg Gin Tyr 165 Met Thr Ile Gin Lys 245 His Asn Ser Gin Arg 325 Glu Lys Phe Cys Leu 405 Glu Thr Leu Giu Tyr 485 Glu Phe Gmn Ser Leu 565 Pro Leu Tyr Leu Glu Phe 150 Ser Glu Thr Lys Phe 230 Asp Cys Asp His Phe 310 Tyr Ser Asn Lys Asn 390 Ser Pro Gly Phe Phe 470 Phe Ile Ser Leu Phe 550 Ile Gin Pro Ala Ser Ile 135 Phe His Asp Asp Glu 215 Asn Phe Lys Leti Ala 295 Tyr Arg Ile Ile Gin 375 Pro His Lys Leu Asn 455 Asn Asp Asp Ile Glu 535 Ala Thr Asp Arg Asn Gly 120 Ile Ile Leu Ile Phe 200 Ile Glu Glu Asn Leu 280 Val Leu Tyr Lys Gly 360 Ser Tyr Gin Ile Ala 440 Lys Lys Ser Gin Gin 520 Phe Giu Lys Ser Glu Val 105 Asn Lys Ile Lys Leu 185 Thr Asp Phe Arg Giu 265 Lys Asn Lys Ser Ile 345 Glu Lys Thr Phe Thr 425 Ser Thr Arg His Glu 505 Lys Phe Ile Glu Tyr 585 Lys Thr Asn Tyr Gly Glu 170 Lys Lys Glu Glu Asn 250 Cys Asn Asp Gin Asn 330 Leu Ile Asn Ala Glu 410 Asp Gin Asn Ser Glu 490 Ser Ile Glu Leu Phe 570 Gin Tyr 1407 Asp Lys Leu Asn Asn Leu Gin Leu Val 125 Asn Ala Pro 140 Lys Gly Lys 155 Leu Ser Ala Lys Leu Glu Phe Thr Pro 205 Lys Tyr Pro 220 Ser Asn Ile 235 Lys Glu Ser Asn Ser Glu Ile Gin Gin 285 Val Ser Lys 300 Ile Asp Leu 315 Leu Phe Glu Asp Asn Glu Lys Asp Lys 365 Val Ser Glu 380 Phe Asn Phe 395 Lys Phe Val Asn Asp Leu Leu Ser Gly 445 Phe Asn Pro 460 Lys Ile Lys 475 Ser Phe Asn Leu Lys Lys Glu Ser Lys 525 Asn Asp Thr 540 Glu Tyr Asn 555 Asn Lys Leu Leu Lys Ile Thr Glu His Lys Leu 110 Lys Asn Gin Ser Glu 190 Lys Ile Glu Leu Glu 270 Ile Asp Leu Pro Ser 350 Phe Phe His Pro Glu 430 His Asn Phe Ile Ile 510 His Ser Met Leu Arg 590 Glu Leu Phe Asn Lys Lys Glu 175 Leu Thr Asn Lys Ile 255 Glu Cys Ile Val Ile 335 Gly Giu Aia Leu Ile 415 Ala Trp Lys Asp Ser 495 Lys Asp Phe Gin Ala 575 Val Ile PEA/JS 18 0EC1996 Ser Lys Phe Glu Gin 160 Ile Asp Giu Glu His 240 Arg Pro Lys Lys Asn 320 Gin Ile Ala Glu Asn 400 Met Ile Phe Ile Lys 480 Lys Gin Asn Leu Leu 560 Ile Arg Lys POUS 96/O91a2.
WpEMus 18 0 E 1996 1409 Leu Ile 625 Phe Ile Arg Val1 His 705 Ile Asp Phe Asp Tyr 785 Lys Leu Phe Met Phe 865 Ala Leu Leu Giu 610 Leu Giy Ile Lys Thr 690 Leu Lys Ala His Tyr 770 Lys As n Asp Asn His 850 Lys Lys Tyr Lys 595 Val Ser Phe Tyr Giu 675 Phe Asp Asn Leu Asri 755 Cys Asp Asp As n Gin 835 Asp Gin Asn Gly Leu 915 Arg 615 Thr Val Giu Phe Thr 695 Ile Lys His Ala 775 Pro Met Val1 Ser Ile 855 Cys Giu Ala Ile 600 Lys Gly Giy Pro Leu 680 His Vali Pro Arg Arg 760 Phe Phe Lys Leu Giu 840 Leu Phe Leu Ile Ala 920 Ser Phe Ser Ala 665 Lys Asp Giu Leu Ser 745 Ile Lys Thr Giu Thr 825 Arg Gin Ser Ser Giu 905 Trp Giu As n Asn Vali 670 Lys Asp Gly Lys Gin 750 Gly Tyr Ser Leu Lys 830 Asn Asp Asn Thr Arg 910 Ile Pro Phe His 655 Pro As n Thr Ser Asp 735 His Ile Lys Gly Cys 81i5 Cys Giu Arg Lys Arg 895 Asn Lys Ile Met 640 Asn Ala His Asp Val 720 Ser Vali Thr Giu Leu 800 Giu Val1 G iu His Tyr 880 Leu Phe Asn INFORMATION FOR SEQ ID NO:i882: SEQUENCE CHARACTERISTICS: LENGTH: 291 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANlISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .291 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1882 IRAL4 Gin Ala Leu Giy Ile Asn Met Cys Ser Lys Lys Ile Arg Asn Leu Ile 10 is
/VT
firis 9 6/ 2 I PEJVUS 18 0 EG1996 Leu Lys Asp Lys Giu Leu Lys Ala Pro 145 Gly Lys As n Ala Gin 225 Leu Phe Phe Tyr Cys Giu Ala Glu Giu His Ser Asn 130 Leu Ile Gly Ilie Leu 210 Asn Val1 Glu Leu Leu 290 Phe Asn Pro G lu Ile Giu Gly 115 Pro Leu Ser Phe Asp 195 Gly Leu Leu Leu Tyr 275 Leu Gly Met Ile Asn His Lys 100 Phe Tyr Ala Lys 180 Leu Ile Lys Asn Ala 260 Tyr Phe Thr Leu Glu Lys Asn Phe Glu Gly Leu 165 Ser Leu Phe Giu Leu 245 Leu Phe Ile Giu Leu Val1 70 Lys Giu Ile Lys Leu 150 Arg Asp Met G ly Ile 230 Gly Lys Lys Leu Thr Giu 55 Ala Lys Ser Gly Phe 135 Arg Phe Ser Asp Gly 215 Arg Val1 Met Ser Ser As n 40 Giu Lys Arg Ile Val 120 Glu Se r Tyr Leu Lys 200 Val1 Gly Ser Pro Thr 280 Leu 25 Thr Lys Lys Gin Leu 105 Ile Leu Gly Gly Ala 185 Pro Gly Tyr Met Pro 265 As n 1409 Cys Ala Glu Thr Glu Glu Arg Ala Gin Ile Asp Giu 75 Leu Tyr Met 90 Phe Gin Gin Leu Gly Asp Leu Ser Asn 140 Tyr Gin Lys 155 Glu Tyr Leu 170 Ser Tyr Gin Ile Asp Lys Val Gly Trp 220 Ser Gin Pro 235 Thr Leu Asn 250 Leu Lys Giu Ile Tyr Tyr Giu As n Thr Lys Leu Met Ile 125 Ile Tyr Gly Thr Giu 205 Asn Asn Leu Thr Ile 285 Asn Thr Leu Ser Lys Ala 110 Gly Gin Phe Gly Ala 190 Lys Gly Ala Lys Ser 270 Ser Ile Pro Giu Leu Gly Lys Ile Ala Ala Ala 175 Ser Arg Met Phe His 255 Gin Tyr Thr Lys Leu Leu Giu Asn Asn Ser As n 160 Met Leu Phe Tyr Gly 240 Arg Thr Asn INFORMATION FOR SEQ ID NO:1883: SEQUENCE CHARACTERISTICS: LENGTH: 226 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .226 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1883 Phe Phe Arg Lys His Arg Val Ile Ser Met Lys Glu Ile Val Thr 10 Giu Asn Val Ser Phe Asn Tyr His Asn Arg Ala Ile Phe Lys Asp 25 tAsn Leu Ser Ile Gin Giu Gly Asp Phe Leu Cys Val Leu Gly Glu 40 7Gly Ser Gly Lys Sen Thr Leu Leu Gly Leu Ile Leu Gly Leu Leu WANS 96/091 2 3 18 DEC 1996 1410 55 Lys Pro Ser Leu Gly Ser Val Lys Ile Phe Asn Glu Thr Leu Ser Asn 70 75 Asn Ala Phe Leu Arg Gln Lys Ile Gly Tyr Ile Ala Gin Gly Asn Ser 90 Leu Phe Pro His Leu Asn Ala Leu Gln Asn Met Thr Phe Cys Leu Asn 100 105 110 Leu Gln Gly Ile Asn Lys Gin Ala Ala Gin Lys Glu Ala Lys Ala Leu 115 120 125 Ala Leu Lys Met Gly Leu Asp Glu Ser Leu Met Asp Lys Phe Pro Asn 130 135 140 Glu Leu Ser Gly Gly Gln Ala Gln Arg Val Gly Ile Ile Arg Gly Ile 145 150 155 160 Ile His Arg Pro Glu Leu Ile Leu Leu Asp Giu Pro Phe Ser Ala Leu 165 170 175 Asp Ser Leu Asn Arg Lys Asn Leu Gin Asp Leu Ile Lys Glu Ile His 180 185 190 Gin Asn Ser Cys Ala Thr Phe Ile Met Val Thr His Asp Glu Asn Glu 195 200 205 Ala Gin Lys Leu Ala Thr Lys Thr Leu Glu Ile Lys Ala Leu Lys Gin 210 215 220 Glu Gin 225 INFORMATION FOR SEQ ID NO:1884: SEQUENCE CHARACTERISTICS: LENGTH: 594 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...594 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1884 Met Ala Asp Leu Leu Ser Ser Leu Lys Asn Leu Ser Ser Ser Ser Gly 1 5 10 Val Tyr Gin Tyr Phe Asp Lys Asn Arg Gln Leu Leu Tyr lie Gly Lys 25 Ala Lys Asn Leu Lys Lys Arg Ile Lys Ser Tyr Phe Ser Val Arg Asn 40 Asn Glu Ile Thr Pro Asn Pro Arg Thr Ser Leu Arg Val Gin Met Met 55 Val Lys Gln Ile Ala Phe Leu Glu Thr Ile Leu Val Glu Asn Glu Gin 70 75 Asp Ala Leu Ile Leu Glu Asn Ser Leu Ile Lys Gin Leu Lys Pro Lys 90 Tyr Asn Ile Leu Leu Arg Asp Asp Lys Thr Tyr Pro Tyr Ile Tyr Met 100 105 110 Asp Phe Ser Ile Asp Phe Pro Ile Pro Leu Ile Thr Arg Lys Ile Leu 115 120 125 Lys Gln Pro Gly Val Lys Tyr Phe Gly Pro Phe Thr Ser Gly Ala Lys 130 135 140 R spA Asp Ile Leu Asp Ser Leu Tyr Glu Leu Leu Pro Leu Val Gin Lys Lys 150 155 160 V TO PCT/US 9 6 091 22 IPEA/US 18 DEC1996 1411 Asn Cys Ile Lys Glu 225 Ala Phe Met Leu His 305 Ala Gn Leu Gin Leu 385 Ser Asn Ser Asp Arg 465 Phe Tyr Thr Leu Lys 545 Gly Ala Arg Cys Lys Ala Glu 210 Glu Pro Ala Arg Asn 290 Tyr Cys Tyr Ala Glu 370 Phe His Asn Asn Phe 450 Ala Val Arg Phe Arg 530 Leu Glu Ile Lys Ile Lys Ala Pro 180 Lys Glu 195 Leu Glu Ala Leu Phe Thr Phe Tyr 260 Gly Gly 275 Gly Phe Gin Ser Ser Asn Ser Lys 340 Leu Ile 355 Lys Thr Asn Leu His Ser Ala Phe 420 Glu Tyr 435 Ala Lys Gin Leu Glu Val Ser Lys 500 Lys Leu 515 Asp Glu Lys Asn Ala Ser Glu Lys 580 Asp 165 Cys Cys Leu Ile Cys 245 Gly Lys Asp His Glu 325 Lys G1u Ser Glu Asn 405 Gin Asp Glu Asn Ile 485 Gly Leu Ser Met Val 565 Ala Lys Glu Leu Lys Tyr 230 Met Gly Ile Thr Leu 310 Thr Ile Ile Asn Cys 390 Ser Lys Gin Pro Ile 470 Ala Gly Pro His Lys 550 Lys Ser Lys Asp Glu Met 215 Arg Asp Asn Ile Asp 295 Pro Leu Ala Ala Glu 375 Val Gin Asp Met Pro 455 Ala Ile Ala Ser Arg 535 Gin Lys Asp Ala Lys Met 200 Glu Asp Leu Asn Ser 280 Glu Leu Lys Leu Met 360 Asp Pro Cys Ser Ser 440 Pro Leu Ser Lys Asp 520 Tyr Ile Leu Gin Cys Ile 185 Ile Arg Arg Ala Lys 265 Ser Ala Met Glu Ser 345 Lys Arg Tyr Val Tyr 425 Glu Asn Glu Lys Asp 505 Lys Ala Ala Leu Glu 585 Met 170 Thr Glu Leu Ile Lys 250 Ala Ala Met Pro Leu 330 Ile Asn Ile Arg Gly 410 Arg Leu Leu Ile Glu 490 Ile Arg Ile Leu Asp 570 Lys Phe Lys Asn Ser Ala 235 Leu Val Phe Lys Glu 315 Gin Pro Ala Leu Val 395 Gly Arg Leu Trp Leu 475 Lys Ile Leu Asn Leu 555 Tyr Tyr Glu Lys Ser 220 Lys Tyr Leu Glu Gln 300 Gin Glu Lys Gin Glu 380 Glu Met Tyr Thr Val 460 Lys Arg His Gin Phe 540 Lys Phe Gin Glu Asp 205 Asn Ile Asp Val Lys 285 Ala Ile Phe Lys Glu 365 Glu Ile Val His Arg 445 Ile Ser Asp Thr Trp 525 His Glu Gly Ile Tyr 190 Arg Leu Gln Leu Lys 270 Ile Ile Leu Ile Gly 350 Ile Ala Phe Val Leu 430 Arg Asp Ser Ser Ile 510 Val Arg Lys Ser Glu 175 Leu Leu Arg Lys Asp 255 Met His Ile Leu Ser 335 Asp Phe Arg Asp Tyr 415 Lys Ala Gly Gly Lys 495 Ser Gin Ser Gly Phe Arg Lys Ile Phe Ile 240 Ile Phe Ser Asn Ser 320 His Lys Ser Ser Thr 400 Glu Gly Leu Gly Ser 480 Ala His Lys Thr Ile 560 Glu Asn Ala Val 575 Leu Lys Lys 590 INFORMATION FOR SEQ ID NO:1885: SEQUENCE CHARACTERISTICS: LENGTH: 424 amino acids TYPE: amino acid TOPOLOGY: linear P T/US 96/09122 1412 IPE US 18 DEC 1996 (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...424 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1885 Arg Lys Asn Met Lys Lys Arg Leu Asn Ile Gly Leu Val Gly Leu Gly 1 5 10 Cys Val Gly Ser Thr Val Ala Lys Ile Leu Gin Glu Asn Gin Glu Ile 25 Ile Lys Asp Arg Ala Gly Val Glu Ile Lys Ile Lys Lys Ala Val Val 40 Arg Asp Val Lys Lys His Lys Gly Tyr Ala Phe Glu Ile Ser Asp Asp 55 Leu Glu Ser Val Ile Glu Asp Lys Gly Ile Asp Ile Val Val Glu Leu 70 75 Met Gly Gly Val Glu Ala Pro Tyr Leu Leu Ala Lys Lys Thr Leu Ala 90 Lys Gin Lys Ala Phe Val Thr Ala Asn Lys Ala Met Leu Ala Tyr His 100 105 110 Arg Tyr Glu Leu Glu Gin Ile Ala Lys Asn Thr Pro Ile Gly Phe Glu 115 120 125 Ala Ser Val Cys Gly Gly Ile Pro Ile Ile Lys Ala Leu Lys Asp Gly 130 135 140 Leu Ser Ala Asn His Ile Leu Ser Phe Lys Gly Ile Leu Asn Gly Thr 145 150 155 160 Ser Asn Tyr Ile Leu Ser Gln Met Phe Lys Asn Gln Ala Ser Phe Lys 165 170 175 Asp Ala Leu Lys Asp Ala Gin His Leu Gly Tyr Ala Glu Leu Asn Pro 180 185 190 Glu Phe Asp Ile Lys Gly Ile Asp Ala Ala His Lys Leu Leu Ile Leu 195 200 205 Ala Ser Leu Ala Tyr Gly Ile Asp Ala Lys Leu Glu Glu Ile Leu Ile 210 215 220 Glu Gly Ile Glu Lys Ile Glu Pro Asp Asp Met Glu Phe Ala Lys Glu 225 230 235 240 Phe Gly Tyr Ser Ile Lys Leu Leu Gly Ile Ala Lys Lys His Gln Asp 245 250 255 Cys Ile Glu Leu Arg Val His Pro Ser Met Ile Lys Asn Glu Cys Met 260 265 270 Leu Ser Lys Val Asp Gly Val Met Asn Ala Ile Ser Val Ile Gly Asp 275 280 285 Lys Val Gly Glu Thr Leu Tyr Tyr Gly Ala Gly Ala Gly Gly Glu Pro 290 295 300 Thr Ala Ser Ala Val lie Ser Asp Ile Ile Glu Ile Ala Arg Lys Lys 305 310 315 320 Ser Ser Leu Met Leu Gly Phe Glu Thr Pro Gin Lys Leu Pro Leu Lys 325 330 335 Pro Lys Glu Glu Ile Gin Cys Ala Tyr Tyr Ala Arg Leu Leu Val Ser 340 345 350 Asp Glu Lys Gly Val Phe Ser Gin Ile Ser Ala lie Leu Ala Gin Asn 355 360 365 Asp Ile Ser Leu Asn Asn Val Leu Gin Lys Glu Ile Pro Gin Ser Asn 370 375 380 Lys Ala Lys Ile Leu Phe Ser Thr His Thr Thr Asn Glu Lys Ser Met 385 390 395 400 Leu Asn Ala Leu Lys Glu Leu Glu Asn Leu Gin Ser Val Leu Asp Thr 405 410 415 PCIUS 96/U9i S18 8DEC 996 1413 Pro Lys Met Ile Arg Leu Giu Asn 420 INFORMATION FOR SEQ ID NO:1886: SEQUENCE CHARACTERISTICS: LENGTH: 326 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc..feature LOCATION .326 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1886 Sen Arg Phe Lys Arg Ala Ile Giu Gin Ala Phe Ang 1 Ile Leu Giy Pro Gin Gin Gly Pro Val1 145 Val1 Leu Phe Ile Ser 225 Arg As n Asp Gin Val1 305 RA1 Ser 0u Asp Tyr Met Giy Giu Arg Lys Lys 130 Ser Ala Ala Arg Giu 210 Gly Giu As n Giu Gly 290 Val1 Tyr Cys Ala Ala Thn Pro Gly Val Lys Gin Cys Vai Ser 100 Thr Phe 115 Arg Thn Thr Cys Val Leu Asi Ile 180 Cys Ala 195 Phe Leu Val Ser Leu Val Ala Val 260 Tyr Gly 275 Leu Phe Cys Ala Leu Glu 5 Ile Arg Giy Giu Phe Lys Glu Gly Ala Gly 165 Cys Pro Thr Sen Val1 245 Leu Se r Ala Ala His Gly Gly Ile 55 Val1 Phe Giy Lys Lys 135 Cys Gly Lys Thr Tyr 215 Ser Gly Gin Val1 Giy 295 Asp Gly Val1 40 Thr Ser Gly Ser Sen 120 Gly Asp Asp Val1 Leu 200 Val1 Ile Leu G iu Val1 280 Asp Gly Gly 25 Lys Gly Gly Leu His 105 Val1 Giu Gly Thr Tyr 185 Giu Val Lys Phe Asp 265 Asp Ile Ala Pro As n Ser Leu Lys Phe Ile Ser Phe Ala 170 Leu His Giu Asn Ile 250 Asn Phe Arg Thr Ala Ala Sen Asp 75 His Val1 Ile Giu Phe 155 Val1 Ile Ala Giu Thr 235 Phe Ser Ser Ile Ala 315 G ly Val1 Giu Phe Glu Ile Ala Tyr 140 Tyr Giu His Lys Ile 220 Ala Val1 Met Met Phe 300 Ala Leu Leu Leu Ile Met Met Leu Thr 125 Trp Lys Giu Arg Asn 205 Lys Thr Gly Leu Lys 285 Ala Leu Val1 Sen Phe Giu Gin Thn Ala 110 Gly Gly As n Ala Ang 190 Asn Gly Asn Tyr Cys 270 Thn Pro Sen Met Gly Lys Tyr Trp Ile Asp Sen Gly Giu 160 Tyr Gly Lys Ala Lys 240 Val1 Cys Val1 Gin Ile 320 alA-/US 9 6/ 09 12 ~~~Vb8 8DEC 1996 1414 325 INFORMATION FOR SEQ ID NO:1887: SEQUENCE CHARACTERISTICS: LENGTH: 279 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .279 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1887 Lys Lys Leu Ile His Ala Tyr His Ile Asp 145 His As n Gly Phe Asp 225 Val1 Pro Leu Leu Trp Giu Phe Ser Leu Arg Val Phe Ile Ile Val1 Asn Leu Thr His Leu 130 Phe Leu Gin Val Leu 210 Ala Ile Tyr Lys Cys Asn Sen His Ser Ala Sen 115 Glu Leu Leu Glu Gly 195 Lys Thn Ala Ser Trp 275 Asp Ile Lys Pro Leu Lys 100 Leu Asp Glu Tyr Ile 180 Thr His Ph.
Asp Pro 260 Trp Lys As n Thr Tyr Ile Phe Trp Asp Lys Asp 165 Gin Gin Ser Ile Asp 245 Lys Gin Leu His 40 Gly Thr Val1 Leu Cys 120 Leu Gin Val Val1 Val 200 Trp Val Ile Leu Val1 His Gly Gin Ser Gly 105 Ile Lys Giu Lys Gly 185 Ile Val1 Lys Sen Met 265 Phe Gin Leu As n Lys Glu Giu Giu Leu Sen 170 Ile Thr Val1 Asn Thr 250 Ang Arg Ala His Ile Phe Leu Leu Asp Gly 155 Glu Ile Pro Pro Leu 235 Ile Giu Ser Thr Ile Leu Asp Tyr Cys Glu 125 Lys Ala Leu Ala Ile 205 Asp Leu Arg His INFORMATION FOR SEQ ID NO:1888:
/V/O
Ci) SEQUENCE CHARACTERISTICS: LENGTH: 236 amino acids PCT/US 96/0912.2 IPENUS 1 8 D£C1996 1415 TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...236 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1888 Gly Asp Phe Ile Ile Ser Asn Ile Ser Ile His Pro 1 Lys Thr Thr Asn Val Leu Phe Gin Leu 145 Ile Ser Val Ser Thr 225 Asn Ala Ile Ile Val Phe Glu Lys 130 Val Arg Ile Leu Ile 210 Thr Ala Ile Leu Pro Ser Lys Lys 115 Gin Ile Leu Ile Leu 195 Leu Lys Leu Ile Gly Tyr Asn Phe 100 Asn Arg Met Ser Ala 180 Leu Lys Asp 5 Asn Gly Ile His Leu Tyr Leu Leu Asp Asn 165 Thr Lys Ser Leu Ile Thr Arg Asp 70 Phe Gin Leu Lys Glu 150 Leu His Asn Val Leu 230 Gin Asn Ser 55 Asn Asn Phe Asn Ile 135 Pro Ile Asp Gly Ala 215 Ala Asp Gly 40 Asp Val Tyr Phe Lys 120 Asp Glu Ser Pro Asn 200 Lys Leu Phe 25 Ala Tyr Ile Pro His 105 Thr Leu Thr Leu Ile 185 Ile Thr Leu 10 Ser Gly Asn Pro Pro 90 Lys Tyr Ala Ser Arg 170 Val Ala Phe Lys Phe Lys Phe Gin 75 Gly Asn Glu Leu Leu 155 Asn Leu Gin Asn Asp 235 Lys Ser Lys Arg Leu Cys His Ser 140 Glu Thr Asp Tyr Phe 220 Ile Lys Asn Thr Ala Lys Asn Thr Leu 125 His Gin Gin Ser Lys 205 Lys Thr His Leu Gin Gin Ala Leu 110 Ser His Asn Gin Cys 190 Pro Glu Met Thr Ile Asn Leu Asn Asp Asp Pro Ala Leu 175 Glu Leu Lys Phe Ser Asn Asn Gly Asp Leu Gly Gin Leu 160 Thr Trp Asn Pro INFORMATION FOR SEQ ID NO:1889: SEQUENCE CHARACTERISTICS: LENGTH: 113 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature R A ,I LOCATION .113 AMENDED
SHEF
ritGUS 96/091 2 C1 1996 1416 Ile 1 Asn Met Ala Ser Gly Ser Phe (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1889 Tyr Ser His Leu Ala Pro Ile Met His Tyr Gin 5 Ile Ile Gln Asp Leu Phe Ile Thr Cys His Val Arg Val Phe Val Cys Phe Leu Gly Val Phe Val Arg Phe Gly Tyr Val Val Leu Ile Pro Leu Leu 55 Leu Thr Pro His Gln Ser Phe Gln Leu Gly Ile 70 Tyr Val Phe Gly Ser Phe Leu Ile Gln Phe Leu Leu Glu Ser Ile Ala Lys Ile Ser Phe Lys Leu 100 105 INFORMATION FOR SEQ ID NO:1890: SEQUENCE CHARACTERISTICS: LENGTH: 80 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...80 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1890 Ser Met Gly Gly Phe Thr Ser Ile Trp His Trp Val Ile Val Leu 1 5 10 Val Ile Val Leu Leu Phe Gly Ala Lys Lys Ile Pro Glu Leu Ala 25 Gly Leu Gly Ser Gly Ile Lys Asn Phe Lys Lys Ala Val Lys Asp 40 Glu Glu Glu Ala Lys Asn Glu Leu Lys Thr Leu Asp Ala Gln Ala 55 Gin Thr Lys Val His Glu Thr Ser Glu Ile Lys Ser Lys Gln Glu 70 75 INFORMATION FOR SEQ ID NO:1891: SEQUENCE CHARACTERISTICS: LENGTH: 267 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: Leu Lys Asp Thr Ser C '1C996 1417 ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...267 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1891 Arg Lys Thr Asn His Lys Arg Leu Ile Ser Val Thr Lys Gly 1 Met Thr Leu Tyr Ala Ile Leu Ile Asn 145 Leu Glu Met Gin Ile 225 Thr Arg Gly Asn Leu Phe Ile Phe Ala Phe 130 Phe Phe Gin Ser Leu 210 Lys Phe Met lie Ser Leu Asn Gly Phe 100 Ile Val Ala Phe Ile 180 Asn Ile Phe Ile Leu 260 Leu Ala Ile Ile Leu Tyr Ala Leu Leu Cys 165 Leu Val Lys Gin Ile 245 Thr Ser Leu Phe Ile Thr Met Ser Ser Ile 150 Leu Gly Phe Thr Gly 230 Gly Pro Ile Phe Val Gly Gin Leu Arg Phe 135 Leu Ala Phe Val Ser 215 Ile Gly Lys Leu Trp Phe Leu Ala Ser Leu 120 Tyr Gly Ile Cys Pro 200 Ile Asp Ile Glu Lys Thr Ser Met Ile Pro 105 Ile Ala Phe Phe Asn 185 Leu Phe Thr Ile Arg 265 INFORMATION FOR SEQ ID NO:1892: SEQUENCE CHARACTERISTICS: LENGTH: 272 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...272 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1892 Lys Gln Glu Met Lys Lys Leu Leu Leu Leu Leu Glu His Lys Ile PGTIIS 96/0912a IPEA/Us 18 8D EC 1996 1418 1 Val1 Phe Lys As n Ser As n Thr Giu Gin 145 Ile Ser Ser Giu Leu 225 Ile Ala Lys Tyr Phe Lys Val1 Ala Leu Asp 130 Lys Lys Val1 Ser Lys 210 Leu Gly Ser Ile Giu Pro Ile Asn Leu Ile 115 Giu Giu Ser Ser Phe 195 Leu Ser Leu Asn Gly Gin Thr Asp Giu Val1 100 Lys Lys Thr Lys Phe 180 Giu Lys Ser Ile Asn 260 Leu Glu Ser Thr Asn Gin Pro Asn Gin Giu 165 Gly Val1 Ser Leu Phe 245 Ser Ile Ile Ser Ile Ile Lys Gin Arg Pro 150 Lys Ser Ser Phe Phe 230 Cys Leu Ile Lys 55 As n Giu Leu Ser Leu 135 Pro Arg Phe Phe Leu 215 Cys Phe Glu Val1 Giu 40 Leu Gin Lys Pro Pro 120 Val Ile Giu Ser Leu 200 Lys His Ser Phe Ile 25 Lys Phe Val1 Thr Asn 105 Phe Ile Ser Leu Leu 185 Ser Aia Pro Lys Ser 265 10 Vali Aia Gin Lys Gin 90 Leu Phe Leu Ile Giu 170 Leu Arg Phe Lou Phe 250 Ser Leu Val1 Aia Pro 75 Lys Pro Asn Ala Lys 155 Lys Ser Gly Ser Ser 235 Ser Leu Val1 Asn Tyr Asn Asp Lys Tyr Ser 140 Asn Giu Ser Ile Ser 220 Lou Arg Ser Gly Val1 Glu Asp Leu Asp As n 125 Arg Ser Trp Ser G ly 205 Ser Phe Giu Arg Phe Ser Gly Giu Asp Phe 110 Thr Ile Val1 Ala Sor 190 Leu Leu Cys Leu Leu 270 Phe Gin Ile Thr Asp Asn Ala Ser Ser Lys 175 Ser Asp Phe Ser Val1 255 Gly Leu Gly Lys Lys Phe Lys Asn Ser His 160 Pro Phe Cys Ser Leu 240 Asn Ser INFORMATION FOR SEQ ID NO:1893: SEQUENCE CHARACTERISTICS: LENGTH: 338 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .338 (xi) SEQUE14CE DESCRIPTION: SEQ ID NO:1893 Lys Ile Phe Lys Lys Ala Leu Arg His Lys Met Giu Lys Vai Cys Val 1 5 10 Ser Ala Trp Gly Leu Pro Lys Ile Leu Giu Giu Arg Leu Lys Giu Lys 25 Tyr Gly Asp Asp Trp Giu Lys His Val Lys Ala Lys Ala Ile Asn Giu 40 Giu Giu Leu Giu Giu Gin Val Lys Ala Lys Ala Lys Giu Gln Gin Lys s0 55 ~~Thr Gin Arg Giu Lys Thr Leu Asn Gly Phe Leu Lys Lys Val Gly Leu i 70 75 IPENAUS 18 Dr,_C1996 Lys Giu Ph.
Ile Thr 145 Lys Tyr Ile Phe Asn 225 Thr Leu Pro Ile Asp 305 His Glu Lys Ala Ser Ile 130 Phe Ser Val1 Ala Phe 210 Leu Gin Giu Ile Val1 290 Giu Val1 Gin Arg Asp Ser 115 Val Ser Ile Asn His 195 Glu Thr Ala Ser Giu 275 Thr Lys Glu 1419 Leu Phe Lys Ile Ala Leu Lys Val 140 Ile Val 155 Arg Gin Ile Lys Ala Phe Ser Ile 220 Ile Ala 235 Leu Phe Met Thr Leu Asn Ala Ile 300 Val Lys 315 Asp Gly Ile 125 Pro Gin Leu Glu Giu 205 Leu His Phe Pro 285 Leu Ser Giu Asp 110 Giu Tyr Arg Val1 Gin 190 Val Thr Ile Lys Giu 270 Thr Lys Arg Val1 Trp Ala Leu Ala Ala 175 Asn Trp Asn Ser Giu 255 Phe Gly Asp Ile Lys Ile Ile Val Asp 160 Ser Giu Asp Ile Lys 240 Lys Glu Ph.
Leu Ile 320 Pro His Met Ser Gin Tyr Lys Asp Val Lys 335 INFORMATION FOR SEQ ID NO:i894: SEQUENCE CHARACTERISTICS: LENGTH: 310 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .310 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1894 Val Vai Val Ile Arg Leu Vai Leu Asn Met Leu Thr Cys Gin Ile Ser 1 5 10 Tyr Ilie Arg Ile Ser Tyr Leu Vai Ser Vai Ser Asp Phe Val Ile Cys 25 Lys Giu Arg Ph. Met Asp Giu Ile Lys Thr Leu Leu Val Asp Ph. Phe 40 Pro Gin Ala Lys His Ph. Gly Ile Ile Leu Ile Lys Aia Ile Val Val 55 e Cys Ile Gly Ph. Tyr Ph. Ser Ph. Ph. Leu Arg Asn Lys Thr Met Tu POT/US 96 091 2a2a IU I 8ii0 W61 1420 Lys Val1 Thr Gly Gly 145 Ile Asn Arg Arg Leu 225 Asp Ser Phe Ala Lys 305 Leu Thr Leu Ile 130 Gly Giu Thr Ser Arg 210 Val1 Lys Leu Asn As n 290 Gin Leu Phe Gly 115 Ala Ile Ile Ser Val1 195 Ile His Asn As n Val1 275 Arg Asp Lys Leu Gin Ala Leu Gly 165 Arg Asn Trp Thr Pro 245 Thr Ser Glu Ser 70 Lys Ile Thr Leu Ile 150 Leu Leu Ser Val Ile 230 Thr Ile Giu Ile Lys 310 Asp Leu Thr Ala 135 Ile G iu His Asn Cys 215 Lys Phe Arg Leu Pro 295 Glu Ile Ser 120 Leu Leu Gly Asp Ile 200 Gly Asp Ile Val1 Ile 280 Phe Ile Ile 105 Ile Lys His Lys Gly 185 Ile Val1 Val1 Gly Trp 265 Giu As n Leu 90 Thr Ile Asp Pro Val1 170 Arg Asn Gly Ile Ile 250 Ala Arg Lys Asn Ile Val1 Leu 140 Lys Ala Ala Asn G ly 220 Gly Asp Ile Lys Asp 300 Val Ala 110 Gly Ser Gly Asn Leu 190 Thr Asp Glu Gly Asp 270 Ala Ser Ala Leu Thr Ile Asp Phe 175 Pro Ala Ile Lys Gin 255 Gly Leu Ile Gin Ser Val1 Ala Ile 160 Phe Asn Cys Glu Ile 240 Ser Ile Asp As n INFORMATION FOR SEQ ID NO:1895: SEQUENCE CHARACTERISTICS: LENGTH: 159 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL: YES (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .159 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1895 Ser Lys Arg Thr Gin Gin Thr Phe Phe Leu Phe Ile 1 5 Asp Tyr Ile Met His Pro Ile Met Phe Ala Tyr Ile 25 Ala Gin Ala Ang Lys Ile Asn Gly Thr Leu Cys Met 40 Ile Ser Gin Vai Lys Giu Leu Gly Ile Asp Lys Ala 55 Giy Asn Leu Ser Gin Val Ile Ile Tyr Pro Thr Lys 70 X Leu Ile Giu Cys Gly Val Pro Leu Sen Asp Sen Glu Ou Asp Ala Ala Lys Asp Ile GiU Asn Phe Sen Thr Asn His Thr Asn Met 145 I~i'Ps ~DE.C 1996 1421 Thr Asp Met Arg Ala Arg Gin Val Leu Val Lys Asn Ile Val 100 105 110 Ala Ser Ala Phe Ile Glu Ile Asp Leu Lys Lys Ile Cys Lys 115 120 125 Phe Ile Phe Leu Ile Ala Met Leu Val Ile Giu Lys Ser Ser 135 140 Leu Lys Lys Gin Thr Lys Lys Leu Ile Arg Lys Ser Ile iSO 155 INFORMATION FOR SEQ ID NO:i896: SEQUENCE CHARACTERISTICS: LENGTH: 258 amino acids TYPE: amino acid TOPOLOGY: linear (ii) MOLECULE TYPE: protein (iii) HYPOTHETICAL:
YES
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc-feature LOCATION .258 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1896 Leu Leu Lys Asn Ilie Asp Glu Lys Lys Leu Ser Val Ser Lys 1 Glu Cys Sen Asn Val1 Val Ile Asn Ser 145 Thr Phe Glu Thr Asp 225 Lys Ala Lys Leu G iu Val1 Giu Ser 130 Sen Lys Phe Leu His 210 His Arg Phe Gly Phe Glu Lys Trp 115 Lys Arg Arg Ile Lys 195 Lys Leu His Leu Leu Sen Ser Thr 100 Ala Giu Val1 Tyr Lys 180 G iu Lys Lys 5 Met Cys His Ilie Asp Gin Lys Asp Tyr Asp 165 Glu Gin Ala Asp Asp Phe Met Leu 70 Lys Ile Tyr Val Giu 150 Leu Ile Gly Leu Ile 230 Phe Ser Gin 55 Asp Ala Asn Leu Asn 135 Ala Ile G iu Leu Glu 215 Tyr Lys Asn 40 Lys Lys Asn Lys Ser 120 Phe Asn Asp Ile Giu 200 Asn Gin Lys Cys Pro 25 Leu Val Leu Lys Lys Pro Gly Asp Val 75 Lys Ile Gin 90 Ala Ser Met 105 Phe Glu Lys Phe Ala Asn Lys Giu Gly 155 Arg Asn Ile 170 Leu Thr His 185 Ile Gin Leu Gly Asn Giu Giu Val Glu 235 Asn Leu Lys Ala Giu Ile Arg Gly 140 Phe Asp Thr Thr Ile 220 Phe Ile Asn Thr Pro Ser Val1 125 Glu Glu Ang Asn His 205 Val1 Giu Giu Pro Asn Leu Arg 110 Tyr Ile Arg Asn Ser 190 His Lys Val1 Lys Ile Gin Asn Pro Asp Lys Lys Ang Ang 175 Leu Asn Asj Asn Lys His Pro Pro Tyr Pro Asp Giu Ile 160 Glu Lys Giu Tyr Giy 240 Arg Thr Lys Sen Ala Gil
I
Gly Leu Val Arg Glu 245 Thr Leu Ile Ile Pro Sen Ser Tyr Phe 255 RA4 PCT/US 96/09122 EA/US 1 DEC 1996 1422 INFORMATION FOR SEQ ID NO:1897: SEQUENCE CHARACTERISTICS: LENGTH: 20 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...20 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1897 TATACCATGG TGGGCGCTAA INFORMATION FOR SEQ ID NO:1898: SEQUENCE CHARACTERISTICS: LENGTH: 23 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...23 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1898 ATGAATTCGA GTAAGGATTT TTG 23 INFORMATION FOR SEQ ID NO:1899: SEQUENCE CHARACTERISTICS: LENGTH: 22 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO PEUS 1 8 DEC1996 1423 (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...22 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1899 TTAACCATGG TGAAAAGCGA TA 22 INFORMATION FOR SEQ ID NO:190 0 SEQUENCE CHARACTERISTICS: LENGTH: 23 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...23 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1900 TAGAATTCGC ATAACGATCA ATC 23 INFORMATION FOR SEQ ID NO:1901: SEQUENCE CHARACTERISTICS: LENGTH: 22 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...22 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1901 ATATCCATGG TGAGTTTGAT GA 22 INFORMATION FOR SEQ ID NO:1902: SEQUENCE CHARACTERISTICS: LENGTH: 25 base pairs PCT/US 96/091 22 IPENUS 1 8 DEC 1996 1424 TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...25 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1902 ATGAATTCAA TTTTTTATTT TGCCA INFORMATION FOR SEQ ID NO:1903: SEQUENCE
CHARACTERISTICS:
LENGTH: 21 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...21 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:190 3 AATTCCATGG TGGGGGCTAT G 21 INFORMATION FOR SEQ ID NO:1904: SEQUENCE CHARACTERISTICS: LENGTH: 23 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori NAME/KEY: misc_feature
LU
AK;-S"T
POT/US 9 6 i- VUS 18 DEC 1996 1425 LOCATION 1...23 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1904 ATGAATTCTC GATAGCCAAA ATC 23 INFORMATION FOR SEQ ID NO:1905: SEQUENCE CHARACTERISTICS: LENGTH: 25 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1905 AATTCCATGG TGCATAACTT CCATT INFORMATION FOR SEQ ID NO:1906: SEQUENCE CHARACTERISTICS: LENGTH: 25 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...25 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1906 AAGAATTCTC TAGCATCCAA ATGGA INFORMATION FOR SEQ ID NO:1907: SEQUENCE CHARACTERISTICS: LENGTH: 24 base pairs TYPE: nucleic acid STRANDEDNESS: double RA4i TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) T o h I-iu& 9 /GtS IPENUS 18 DEC 1996 1426 (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...24 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1907 ATTTCCATGG TCATGTCTCA TATT INFORMATION FOR SEQ ID NO:1908: SEQUENCE CHARACTERISTICS: LENGTH: 23 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...23 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1908 ATGAATTCCA TCTTTTATTC CAC INFORMATION FOR SEQ ID NO:1909: SEQUENCE CHARACTERISTICS: LENGTH: 27 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...27 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1909 CCATGGTG ATTTTAAGCA TTGAAAG T 'D A. PCT/US 96/091 i IPEA/US 18 DEC 1996 1427 INFORMATION FOR SEQ ID NO:1910: SEQUENCE CHARACTERISTICS: LENGTH: 28 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...28 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1910 AAGAATTCCA CTCAAAATTT TTTAACAG 28 INFORMATION FOR SEQ ID NO:1911: SEQUENCE CHARACTERISTICS: LENGTH: 25 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...25 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1911 GATCATCCAT ATGTTATCTT CTAAT INFORMATION FOR SEQ ID NO:1912: SEQUENCE CHARACTERISTICS: LENGTH: 23 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO U6 96/091 2 IPE/VUS 1 8DEC 1996 1428 (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...23 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1912 TGAATTCAAC CATTTTAACC CTG 23 INFORMATION FOR SEQ ID NO::1913 SEQUENCE CHARACTERISTICS: LENGTH: 27 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...27 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1913 TATACCATGG TGAAATTTTT TCTTTTA 27 INFORMATION FOR SEQ ID NO:1914: SEQUENCE CHARACTERISTICS: LENGTH: 25 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1914 AGAATTCAAT TGCGTCTTGT AAAAG INFORMATION FOR SEQ ID NO:1915: SEQUENCE CHARACTERISTICS: LENGTH: 24 base pairs
Q
T
n r R ,u LC 1996 1429 TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...24 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1915 TATACCATGG TGATGGACAA ACTC 24 INFORMATION FOR SEQ ID NO:1916: SEQUENCE CHARACTERISTICS: LENGTH: 23 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION .23 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1916 ATGAATTCCC ACTTGGGGCG ATA 23 INFORMATION FOR SEQ ID NO:1917: SEQUENCE CHARACTERISTICS: LENGTH: 25 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori S(ix) FEATURE: NAME/KEY: miscfeature PCT/US 96/091 i Wi I >101996 1430 LOCATION 1...25 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1917 TTATGGATCC AAACCAATTA AAACT INFORMATION FOR SEQ ID NO:1918: SEQUENCE CHARACTERISTICS: LENGTH: 23 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...23 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1918 TATCTCGAGT TATAGAGAAG GGC 23 INFORMATION FOR SEQ ID NO:1919: SEQUENCE CHARACTERISTICS: LENGTH: 22 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...22 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1919 TTAACCATGG TGAAAAGCGA TA 22 INFORMATION FOR SEQ ID NO:1920: SEQUENCE CHARACTERISTICS: LENGTH: 24 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) ,i PtiUS 9b/ IPEA S 18 DEC 1996 1431 (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: miscfeature LOCATION 1...24 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1920 TAGAATTCGC CTCTAAAACT TTAG 24 INFORMATION FOR SEQ ID NO:1921: SEQUENCE CHARACTERISTICS: LENGTH: 22 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...22 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1921 TTAACCATGG TGAAAAGCGA TA 22 INFORMATION FOR SEQ ID NO:1922: SEQUENCE CHARACTERISTICS: LENGTH: 23 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...23 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1922 \TAGAATTCGC ATAACGATCA ATC 23 ,iT FPT/US 9 6 091 a 2 IPEUS 1 8DEC 1996 1432 INFORMATION FOR SEQ ID NO:1923: SEQUENCE CHARACTERISTICS: LENGTH: 22 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...22 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1923 ATATCCATGG TGAGTTTGAT GA 22 INFORMATION FOR SEQ ID NO:1924: SEQUENCE CHARACTERISTICS: LENGTH: 25 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...25 (xi) SEQUENCE DESCRIPTION: SEQ ID N0:1924 ATGAATTCAA TTTTTTATTT TGCCA INFORMATION FOR SEQ ID NO:1925: SEQUENCE CHARACTERISTICS: LENGTH: 23 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO PCT/US 96 0 2 IPENUS 18 D C1Y9 1433 (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...23 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1925 AATTCCATGG CTATCCAAAT CCG INFORMATION FOR SEQ ID NO:1926: SEQUENCE CHARACTERISTICS: LENGTH: 25 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...25 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1926 ATGAATTCGC CAAAATCGTA GTATT INFORMATION FOR SEQ ID NO:1927: SEQUENCE CHARACTERISTICS: LENGTH: 24 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...24 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1927 GATACCATGG AATTTATGAA AAAG INFORMATION FOR SEQ ID NO:1928: SEQUENCE CHARACTERISTICS: LENGTH: 25 base pairs BA4 wj
T)
PCT/US 96/09122 IPENUS 1 8'DEC 1996 1434 TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...25 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1928 TGAATTCGAA AAAGTGTAGT TATAC INFORMATION FOR SEQ ID NO::1929 SEQUENCE CHARACTERISTICS: LENGTH: 19 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...19 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1929 CCCTTCATTT TAGAAATCG 19 INFORMATION FOR SEQ ID NO:1930: SEQUENCE CHARACTERISTICS: LENGTH: 20 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature IV T POT/US 96/09122 IPEA/S 1 8DEC 1996 1435 LOCATION 1...20 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1930 ATTTCAACCA ATTCAATGCG INFORMATION FOR SEQ ID NO:1931: SEQUENCE CHARACTERISTICS: LENGTH: 20 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...20 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1931 GCCCCTTTTG ATTTGAAGCT INFORMATION FOR SEQ ID NO:1932: SEQUENCE CHARACTERISTICS: LENGTH: 22 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...22 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1932 TCGCTCCAAG ATACCAAGAA GT 22 INFORMATION FOR SEQ ID NO::1933 SEQUENCE CHARACTERISTICS: LENGTH: 22 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) tDJ8S 96/09122 IP3 1436 (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...22 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1933 CTTGAATTAG GGGCAAAGAT CG 22 INFORMATION FOR SEQ ID NO:1934: SEQUENCE CHARACTERISTICS: LENGTH: 22 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...22 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1934 ATGCGTTTTT ACCCAAAGAA GT 22 INFORMATION FOR SEQ ID NO:1935: SEQUENCE CHARACTERISTICS: LENGTH: 22 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...22 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1935 ATAACGCCAC TTCCTTATTG GT 22 i- Th/US 96/0 9 1 2? EA/ D l EC1996 1437 INFORMATION FOR SEQ ID NO:1936: SEQUENCE CHARACTERISTICS: LENGTH: 19 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...19 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1936 CTTTGGGTAA AAACGCATC 19 INFORMATION FOR SEQ ID NO:1937: SEQUENCE CHARACTERISTICS: LENGTH: 20 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...20 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1937 CGATCTTTGA TCCTAATTCA INFORMATION FOR SEQ ID NO:1938: SEQUENCE CHARACTERISTICS: LENGTH: 19 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO /VTN O 1E 71'~ 7_ 3D C 199 6 1438 (vi) ORIGINAL
SOURCE:
ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...19 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1938 ATC AGTTGC CTATGCTGA INFORMATION FOR SEQ ID NO:1939: SEQUENCE CHARACTERISTICS: LENGTH: 22 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...22 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1939 TTGAACACTT TTGATTATGC
GG
INFORMATION FOR SEQ ID NO:1940: SEQUENCE CHARACTERISTICS: LENGTH: 23 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...23 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1940 GGATTATGCG ATTGTTTTAC AAG INFORMATION FOR SEQ ID NO:1941: SR. SEQUENCE CHARACTERISTICS: LENGTH: 21 base pairs L Lwj C Cn PCT/US 96/09122 !PE 3 SDEC1996 1439 TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...21 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1941 GTCTTTAGCA AAAATGGCGT C 21 INFORMATION FOR SEQ ID NO:1942: SEQUENCE CHARACTERISTICS: LENGTH: 21 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...21 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1942 AATGAGCGTA AGAGAGCCTT C 21 INFORMATION FOR SEQ ID NO:1943: SEQUENCE CHARACTERISTICS: LENGTH: 18 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature PCT/US 96/09122 IPEA'LoJ 1 6 1996 1440 LOCATION 1...18 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1943 CTTATGGGGG TATTGTCA INFORMATION FOR SEQ ID NO:1944: SEQUENCE CHARACTERISTICS: LENGTH: 18 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...18 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1944 AGCATGTGGG TATCCAGC INFORMATION FOR SEQ ID NO:1945: SEQUENCE CHARACTERISTICS: LENGTH: 19 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...19 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1945 AGGTTGTTGC CTAAAGACT INFORMATION FOR SEQ ID NO:1946: SEQUENCE CHARACTERISTICS: LENGTH: 18 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) IPEA S 1 DC 1996 (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...18 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1946 CTGCCTCCAC CTTTGATC 18 INFORMATION FOR SEQ ID NO:1947: SEQUENCE CHARACTERISTICS: LENGTH: 19 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...19 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1947 ACCAATATCA ATTGGCACT 19 INFORMATION FOR SEQ ID NO:1948: SEQUENCE CHARACTERISTICS: LENGTH: 18 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...18 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1948 ACTTGGAAAA GCTCTGCA 18 Tll PCTIUS 9 6/ 09i i uJ 6J iJ96 1442 INFORMATION FOR SEQ ID NO:1949: SEQUENCE CHARACTERISTICS: LENGTH: 19 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...19 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1949 CTTGCTTGTC ATATCTAGC 19 INFORMATION FOR SEQ ID NO:1950: SEQUENCE CHARACTERISTICS: LENGTH: 18 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...18 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1950 GTTGAAGTGT TGGTGCTA 18 INFORMATION FOR SEQ ID NO:1951: SEQUENCE CHARACTERISTICS: LENGTH: 22 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO IPE J1 8 DEC 1996 1443 (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...22 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1951 CAAGCAAGTG GTTTGGTTTT AG 22 INFORMATION FOR SEQ ID NO:1952: SEQUENCE CHARACTERISTICS: LENGTH: 22 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...22 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1952 TGGAAAGAGC AAATCATTGA AG 22 INFORMATION FOR SEQ ID NO:1953: SEQUENCE CHARACTERISTICS: LENGTH: 21 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...21 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1953 GCCCATAATC AAAAAGCCCA T 21 INFORMATION FOR SEQ ID NO:1954: SEQUENCE CHARACTERISTICS: LENGTH: 24 base pairs PCT/US 96/09 122 IPEA/US 18 DEC 1996 1444 TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL:
NO
(iv) ANTI-SENSE:
NO
(vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...24 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1954 CTAAAACCAA ACCACTTGCT TGTC INFORMATION FOR SEQ ID NO:1955: SEQUENCE CHARACTERISTICS: LENGTH: 16 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature LOCATION 1...16 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1955 GTAAAACGAC GGCCAG INFORMATION FOR SEQ ID NO:1956: SEQUENCE CHARACTERISTICS: LENGTH: 17 base pairs TYPE: nucleic acid STRANDEDNESS: double TOPOLOGY: circular (ii) MOLECULE TYPE: DNA (genomic) (iii) HYPOTHETICAL: NO (iv) ANTI-SENSE: NO (vi) ORIGINAL SOURCE: ORGANISM: Helicobacter pylori (ix) FEATURE: NAME/KEY: misc_feature T 0 1445 LOCATION .17 (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1956 CAGGAAACAG CTATGAC UP- Vius 2, 1PEWS 'R MPIR6
RA,
0~

Claims (20)

1. An isolated nucleic acid comprising a nucleotide sequence encoding an H. pylori s polypeptide or a fragment thereof, said nuclcotide sequence being at least homologous to a nucleotide sequence selected from SEQ ID NO: 17, SEQ ID NO: 297, SEQ ID NO: 963, SEQ ID NO: 975, SEQ ID NO: 977, SEQ ID NO: 981, SEQ ID NO: 1086, SEQ ID NO: 1203, SEQ ID NO: 1278, SEQ ID NO: 1341, SEQ ID NO: 1351 and SEQ ID NO: 1405.
2. The isolated nucleic acid of claim 1, wherein said nucleotide sequence encodes an H. pylori cell envelope polypeptide or a fragment thereof and is at least 60% homologous to a nucleotide sequence selected from SEQ ID NO: 963, SEQ ID NO: 977, SEQ ID NO: 981, SEQ ID NO: 1086, SEQ ID NO: 1278 and SEQ ID NO: 1405. S
3. The isolated nucleic acid of claim 2, wherein said nucleotide sequence encodes an H. pylori outer membrane polypeptide or a fragment thereof.
4. The isolated nucleic acid of claim 1, wherein said nucleotide sequence encodes an H. 20 pylori secreted or periplasmic polypeptide or a fragment thereof and is at least homologous to a nucleotide sequence selected from SEQ ID NO: 17, SEQ ID NO: 297, SEQ ID NO: 975, SEQ ID NO: 1203, SEQID NO: 1341 and SEQ ID NO: 1351. The isolated nucleic acid of any preceding claim, wherein said nucleotide sequence comprised by the nucleic acid is at least 70%, 80%, 90%, 95%, 98% or 99% homologous to the selected nucleotide sequence, or identical to the selected nucleotide sequence.
6. A recombinant expression vector comprising the nucleic acid of any preceding claim, wherein the nucleic acid includes a transcription regulatory element operably linked to the nucleotide sequence that is comprised by the nucleic acid.
7. A cell comprising the recombinant expression vector of claim 6. 1447
8. A method for producing an H. pylori polypeptide comprising culturing the cell of claim 7 under conditions that permit expression of the polypeptide.
9. A purified polypeptide comprising an amino acid sequence of anH. pylori polypeptide or a fragment thereof, wherein said amino acid sequence is at least 60% homologous to an amino acid sequence selected from SEQ ID NO: 403, SEQ ID NO: 764, SEQ ID NO: 767, SEQ ID NO: 797, SEQ ID NO: 812, SEQ ID NO: 833, SEQ ID NO: 1537, SEQ ID NO: 1654, SEQ ID NO: 1729, SEQ ID NO: 1792, SEQ ID NO: 1802 and SEQ ID NO: 1856. purified polypeptide according to claim 9, wherein saidH. pylori polypeptide or fragment thereof is an H. pylori cell envelope polypepLide or a fragment thereof and said amino acid sequence comprised by the purified polypeptide is at least 60% homologous to an amino acid sequence selected from SEQ ID NO: 764, SEQ fD NO: 812, SEQ ID 1s NO: 833, SEQ ID NO: 1537, SEQ ID NO: 1729 and SEQ ID NO: 1856. 1 l.The purified polypeptide of claim 10, wherein said H. pylori cell envelope polypeptide or a fragment thereof is an H. pylori outer membrane polypeptide or a fragment thereof. 20 12.The purified polypeptide according to claim 9, wherein said H. pylori polypeptide or fragment thereof is an H. pylori secreted or periplasmic polypeptide or a fragment thereof and said amino acid sequence comprised by the purified polypeptide is at least homologous to an amino acid sequence selected from SEQ ID NO: 403, SEQ ID NO: 767, Sm ID NO: 797, SEQ ID NO: 1654, SEQ ID NO: 1792 and SEQ ID NO: 1802.
13.The purified polypeptide of any one of claims 9 to 12, wherein said amino acid sequence comprised by the purified polypeptide is at least 70%, 80%, 90%, 95%, 98% or 99% homologous to the selected amino acid sequence, or identical to the selected amino acid sequence.
14.A vaccine composition suitable for prophylactic or therapeutic treatnent of an H. pylori infection, comprising an effective amount of a nucleic acid according to any one of claims 1 to
15.A vaccine composition suitable for prophylactic or therapeutic treatment of an H. pylori infection, comprising an effective amount of a purified polypeptide of any one of claims 1448 9 to 13.
16.The vaccine composition of claim 14 or 15, further comprising a pharmaceutically acceptable carrier.
17.The vaccine composition of claim 16, wherein the pharmaceutically acceptable carrier is an adjuvant.
18.The vaccine composition of claim 14 or 15, comprising a substance selected from non- toxic derivatives of cholera toxin, procholeragenoid, fungal polysaccharides, phorbol esters, labile toxin of E. coli, non-H. pylori bacterial lysates, block polymers, saponins, biodegradable microcapsules, ISCOMs, cochleates, liposomes and genetically engineered attenuated live viruses or bacteria. is 19.A method of treating a subject for H. pylori infection comprising administering to the S subject a vaccine composition of any one of claims 14 to 18, such that treatment for H. pylori infection occurs.
20.The method according to claim 19, wherein the treatment is a prophylactic treatment.
21.The method according to claim 19, wherein the treatment is a therapeutic treatment.
22.The use of a nucleic acid according to any one of claims 1 to 5 in the manufacture of a vaccine, suitable for prophylactic or therapeutic treatment of an H. pylori infection in a patient administered with the vaccine.
23.The use of a purified polypeptide according to any one of claims 9 to 13 in the manufacture of a vaccine, suitable for prophylactic or therapeutic treatment of an H. pylori infection in a patient administered with the vaccine.
24.The use according to claim 22 or 23, wherein the vaccine comprises an adjuvant. use according to claim 22 or 23, comprising a substance selected from non-toxic derivatives of cholera toxin, procholeragenoid, fungal polysaccharides, phorbol esters, labile toxin of E. coli, non-H. pylori bacterial lysates, block polymers, saponins, biodegradable microcapsules, ISCOMs, cochleates, liposomes and genetically 1449 engineered attenuated live viruses or bacteria.
26.A method for detecting the presence of a Helicobacter nucleic acid in a sample comprising: contacting a sample. with a nucleic acid according to any one of claims I to 5 under conditions in which a hybrid can form between said nucleic acid and a Heliccbacter nucleic acid in the sample; and detecting the hybrid formed in step whereini detection of a hybrid indicates the presence of a Helicobacter nucleic acid in the sample. DATM this 5th day of July 1999 ASRA AK1TEBLAG, its Patent Attorneys, E* WELLUQ 1X& CO.,, Bruce Wellington)
AU63278/96A 1995-06-07 1996-06-06 Nucleic acid and amino acid sequences relating to helicobacter pylori for diagnostics and therapeutics Ceased AU710880C (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU37956/99A AU713692B2 (en) 1995-06-07 1999-07-05 Nucleic acid and amino acid sequences relating to helicobacter pylori for therapeutics
AU37960/99A AU3796099A (en) 1995-06-07 1999-07-05 Assays using nucleic acid and amino acid sequences relating to helicobacter pylori

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US48703295A 1995-06-07 1995-06-07
US08/487032 1995-06-07
US63040596A 1996-04-01 1996-04-01
US08/630405 1996-04-01
PCT/US1996/009122 WO1996040893A1 (en) 1995-06-07 1996-06-06 Nucleic acid and amino acid sequences relating to helicobacter pylori for diagnostics and therapeutics

Related Child Applications (2)

Application Number Title Priority Date Filing Date
AU37956/99A Division AU713692B2 (en) 1995-06-07 1999-07-05 Nucleic acid and amino acid sequences relating to helicobacter pylori for therapeutics
AU37960/99A Division AU3796099A (en) 1995-06-07 1999-07-05 Assays using nucleic acid and amino acid sequences relating to helicobacter pylori

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AU6327896A AU6327896A (en) 1996-12-30
AU710880B2 true AU710880B2 (en) 1999-09-30
AU710880C AU710880C (en) 2000-05-25

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HUP9900766A2 (en) 1999-06-28
EE9700373A (en) 1998-06-15
CZ388697A3 (en) 1998-08-12
CA2223395A1 (en) 1996-12-19
CN1186516A (en) 1998-07-01
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RU98100081A (en) 2005-11-27
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