AU718752B2

AU718752B2 - Novel phenanthridines substituted in the 6 position

Info

Publication number: AU718752B2
Application number: AU22910/97A
Authority: AU
Inventors: Hermann Amschler; Thomas Bar; Rolf Beume; Hildegard Boss; Dieter Flockerzi; Beate Gutterer; Dietrich Hafner; Armin Hatzelmann; Hans-Peter Kley; Thomas Martin; Christian Schudt; Wolf-Rudiger Ulrich
Original assignee: Byk Gulden Lomberg Chemische Fabrik GmbH
Current assignee: Takeda GmbH
Priority date: 1996-03-26
Filing date: 1997-03-24
Publication date: 2000-04-20
Anticipated expiration: 2017-03-24
Also published as: CA2250569C; SI0889886T1; PT889886E; JP4141501B2; AU2291097A; EP0889886A1; WO1997035854A1; ES2184077T3; DK0889886T5; DK0889886T3; DE59708265D1; JP2000507256A; CA2250569A1; EP0889886B1; CY2431B1; ATE224386T1

Abstract

Compounds of formula (I) in which R1, R2, R3, R31, R4, R5, R51 and R6 have the meanings given in the description, are novel effective bronchial therapeutic agents.

Description

B580WOO 03974 1 Novel phenanthridines suYstituted in the 6-position Field of application of the invention The invention relates to novel phenanthridines substituted in the 6-position, which are used in the pharmaceutical industry for the production of medicaments.

Known technical background Chem.Ber. 1939, 72, 675-677, J.Chem.Soc., 1956, 4280-4283 and J.Chem.Soc.(C), 1971, 1805 describe the synthesis of 6-phenylphenanthridines.

Description of the invention It has now been found that the novel phenanthridines substituted in the 6-position described in greater detail below have surprising and particularly advantageous properties.

The invention thus relates to compounds of the formula I (see attached formula sheet), in which R1 is hydroxyl, 1-4C-alkoxy, 3-7C-cycloalkoxy, 3-7C-cycloalkylmethoxy or 1-4C-alkoxy which is completely or partially substituted by fluorine, R2 is hydroxyl, 1-4C-alkoxy, 3-7C-cycloalkoxy, 3-7C-cycloalkylmethoxy or 1-4C-alkoxy which is completely or partially substituted by fluorine, or in which R1 and R2 together are a 1-2C-alkylenedioxy group, R3 is hydrogen or 1-4C-alkyl, R31 is hydrogen or 1-4C-alkyl, or in which R3 and R31 together are a 1-4C-alkylene group, R4 is hydrogen or 1-4C-alkyl, is hydrogen, R51 is hydrogen, or in which and R51 together are an additional bond, R6 is a pyridyl radical which is substituted by R61 or a phenyl radical which is substituted by R7 and R8, where R61 is hydrogen, hydroxyl, halogen, 1-4C-alkoxy, 1-4C-alkyl, carboxyl, trifluoromethyl, 1-4C-alkoxycarbonyl or 1-4C-alkoxy which is completely or partially substituted by fluorine, J t 1 f B580WOO 03974 2 R7 is hydroxyl, halogen, cyano, 1-4C-alkyl, 1-4C-alkoxy, 1-4C-alkylcarbonyloxy, trifluoromethyl, phenyl, phenyl-1-4C-alkyl, nitro, amino, 1-4C-alkoxy which is completely or partially substituted by fluorine, or is S0 2 -R70 or N(R71)R72, where is 1-4C-alkyl, R71 is hydrogen, 1-4C-alkyl, S0 2 -R9 or SO2-R10 and R72 is 1-4-C-alkyl, 1-4C-alkylcarbonyl or S0 2 R8 is hydrogen, hydroxyl, halogen, 1-4C-alkoxy or 1-4C-alkyl and where R9 and R10 independently of one another are 1-4C-alkyl, phenyl, phenyl-1-4C-alkyl or phenyl which is substituted by one or more identical or different substituents, where the substituents are selected from the group consisting of nitro, 1-4C-alkyl, halogen, 1-4C-alkylcarbonylamino, 1-4Calkoxy, 1-4C-alkoxy which is completely or partially substituted by fluorine, cyano, phenyl, naphthyl, trifluoromethyl and 1-4C-alkoxycarbonyl, and the salts of these compounds.

1-4C-Alkoxy represents radicals which, in addition to the oxygen atom, contain a straight-chain or branched alkyl radical having 1 to 4 carbon atoms. Examples which may be mentioned are the butoxy radical, isobutoxy radical, sec-butoxy radical, tert-butoxy radical, propoxy radical, isopropoxy radical and preferably the ethoxy radical and methoxy radical.

3-7C-Cycloalkoxy represents, for example, cyclopropyloxy, cyclobutyloxy, cyclopentyloxy, cyclohexyloxy and cycloheptyloxy, of which cyclopropyloxy, cyclobutyloxy and cyclopentyloxy are preferred.

3-7C-Cycloalkylmethoxy represents, for example, cyclopropylmethoxy, cyclobutylmethoxy, cyclopentylmethoxy, cyclohexylmethoxy and cycloheptylmethoxy, of which cyclopropylmethoxy, cyclobutylmethoxy and cyclopentylmethoxy are preferred.

Examples which may be mentioned of 1-4C-alkoxy which is completely or partially substituted by fluorine are the 1,2,2-trifluoroethoxy radical, the 2,2,3,3,3-pentafluoropropoxy radical, the perfluoroethoxy radical, the 1,1,2,2-tetrafluoroethoxy radical, the trifluoromethoxy radical, in particular the 2,2,2trifluoroethoxy radical and preferably the difluoromethoxy radical.

1-4C-Alkyl represents a straight-chain or branched alkyl radical having 1 to 4 carbon atoms. Examples which may be mentioned are the butyl radical, isobutyl radical, sec-butyl radical, tert-butyl radical, propyl radical, isopropyl radical and preferably the ethyl radical and methyl radical.

1-2C-Alkylenedioxy represents, for example, the methylenedioxy radical (-O-CH 2 and the ethylenedioxy radical (-O-CH 2

-CH

2 i' 1 '0 1.

B580W00 0974 3 If R3 and R31 together have the meaning 1-4C-alkylene, the positions 1 and 4 in compounds of the formula I are linked to one another by a 1-4C-alkylene bridge, 1-4C-alkylene representing straight-chain or branched alkylene radicals having 1 to 4 carbon atoms. Examples which may be mentioned are the radicals methylene (-CH 2 ethylene (-CH 2

-CH

2 trimethy!ene (-CH 2

-CH

2

-CH

2 1,2-dimethylethylene

[-CH(CH

3

)-CH(CH

3 and isopropylidene [-C(CH 3 2 Halogen within the meaning of the present invention is bromine, chlorine and fluorine.

In addition to the carbonyl group, 1-4C-alkoxycarbonyl contains one of the abovementioned 1-4Calkoxy radicals. Examples which may be mentioned are the methoxycarbonyl radical and the ethoxycarbonyl radical.

If R5 and R51 together are an additional bond, then the carbon atoms in the positions 2 and 3 in compounds of the formula I are linked to one another via a double bond.

In addition to -the carbonyloxy radical, 1-4C-alkylcarbonyloxy radicals contain one of the abovementioned 1-4C-alkyl radicals. An example which may be mentioned is the acetyloxy radical (CH 3

CO-O-).

Phenyl-1-4C-alkyl represents one of the abovementioned 1-4C-alkyl radicals which is substituted by a phenyl radical. Examples which may be mentioned are the benzyl radical and the phenethyl radical.

1-4C-Alkylcarbonyl represents a radical which, in addition to the carbonyl radical, contains one of the abovementioned 1-4C-alkyl radicals. An example which may be mentioned is the acetyl radical.

1-4C-Alkylcarbonylamino represents an amino radical which is substituted by one of the abovementioned 1-4C-alkylcarbonyl radicals.'An example which may be mentioned is the acetylamino radical

(CH

3

CO-NH-).

Exemplary pyridyl radicals substituted by R61 which may be mentioned are the radicals pyrid-4-yl, pyrid-3-yl, 2-chloropyrid-4-yl, 2-hydroxypyrid-4-yl, 2-methoxypyrid-4-yl, 2-bromopyrid-4-y, 2-methylpyrid-4-yl, 3-bromopyrid-4-yl, 2-chloropyrid-5-yl, 2-hydroxypyrid-5-yl, 2-methoxypyrid-5-yl, 2-methyl- 2-bromopyrid-5-yl, 3-bromopyrid-5-y, 2-methylpyrid-3-yl, 2-chloropyrid-3-yl, 4-methylpyrid-3yl, 3-methoxypyrid-5-yl, 2-(2,2,2-trifluoroethoxy)pyrid-3-yl, 3-methylpyrid-4-yl, 2-methoxypyrid-3-yl, 2-fluoropyrid-3-yl, 2-trifluoromethylpyrid-3-yl, 2-methoxycarbonylpyrid-3-yl, 4-trifluoromethylpyrid-3-yl, 4-methoxycarbonylpyrid-3-yl or 2-(2,2,2-trifluoroethoxy)pyrid-5-yl.

Exemplary phenyl radicals substituted by R7 and R8 which may be mentioned are the radicals 4-acetamidophenyl, 3-acetamidophenyl, 4-acetoxyphenyl, 3-aminophenyl, 4-aminophenyl, 2-bromophenyl, -bromophenyl, 2-chlorophenyl, 3-chlorophenyl, 4-chlorophenyl, 3-bromophenyl, 2,3-dichlorophenyl, 4 r#tof B580W00 03974 4 2,4-dichiorophenyl, 2-chloro-4-nitrophenyl, 4-diethylarrdno-2-methylphenyl, 4-methoxyphenyl, 3-methoxyphenyl, 2-chloro-5-nitrophenyl, 4-chloro-3-nitrophenyl, 2,6-dichiorophenyl, phenyl, 2,5-dichlorophenyl, 2,6-dibromophenyl, 2-cyanophenyl, 3-cyanophenyl, 4-cyanophenyl, 4-diethylaminophenyl, 4-dimethylaminophenyl, 2-fluorophenyl, 4-fluorophenyl, 3-fluorophenyl, 2,4-difluorophenyl, 2,6-difluorophenyl, 2-chloro-6-fluorophenyl, 2-fluoro-5-nitrophenyl, 2-hydroxyphenyl, 3-hydroxyphenyl, 3,4-dichiorophenyl, 4-hydroxyphenyl, 4-hydroxy-3-methoxyphenyl, 2-hydroxy-4methoxyphenyl, 2,4-di-hydroxyphenyl, 2-methoxyphenyl, 2,3-dimethoxyphenyl, 3,4-dimethoxyphenyl, 2,4-dimethoxy-phenyl, 2-dimethylaminophenyl, 2-methyiphenyl, 3-methyiphenyl, 4-methyiphenyl, 2-chioro-6-methylphenyl, 4-methyl-3-nitrophenyl, 2,4-dimethylphenyl, 2,6-dimethyiphenyl, 2,3-dimethyiphenyl, 2-nitrophenyl, 3-nitrophenyl, 4-nitrophenyl, 2,4-dinitrophenyl, 3,4-dinitrophenyl, nitrophenyl, 2,6-dinitrophenyl, 4-ethoxyphenyl, 2-trifluoromethyiphenyl, 4-trifluoromnethyiphenyl, 3-trig fluoromethyiphenyl, 4-(p-nitrophenylsulfonamido)phenyl, 3-(p-toluenesulfonamido)phenyl, 4-(p-toluenesulfonamido)phenyl, 4-(4-ethylphenylsulfonamido)phenyl, 4-bis(p-toluenesulfonyl)aminophenyl, 4-bis(pnitro-phenyl-sulfonyl)aminophenyl, 3-(p-nitrophenylsulfonamido)phenyl, (N-acetyl-4-p-toluenesulfonamido)phenyl, 4-(benzylsulfonamido)phenyl, 3-(benzyl sulfon amid o)phenyl, 4-(methylsulfonamido)phenyl, 3-(methylsulfonamido)phenyl, 4-(N-methyl methylsulfon amid o)phenyl, 3-(N-methylmethylsulfonamido)phenyl, 4-(3,4-dichlorophenylsulfonamido)phenyl, 3-(3,4-dichlorophenylsulfonamido)phenyl, 4-(3-nitrophenylsulfonamido)phenyl, 3-(3-nitrophenylsulfonamido)phenyl, 4-(4-bromophenylsulfonamido)phenyl, 3-(4-bromophenylsulfonamido)phenyl, 4-(3-bromophenylsulfonamido)phenyl, 3-(3-bromophenylsulfonamido)phenyl, 4-(3-fluorophenylsulfonamido)pheny, 3-(3-fluorophenylsulfonamido)phenyl, 4-(4-fluorophenylsulfonamido)phenyl, 3-(4-fluorophenylsulfonamido)phenyl, 4-(4-chlorophenylsulfonamido)phenyl, 3-(4-chlorophenylsulfonamido)phenyl, 4-(3-chlorophenyisulfonamido)phenyl, 3-(3-chlorophenylsulfonamido)phenyl, 4-(4-acetylaminophenylsulfonamido)phenyl, 3-(4-acetylaminophenylsulfona-ido)phenyl, 4-(4-methoxyphenylsulfonamido)phenyl, 3-(4-methoxyphenylsulfon-, amido)phenyl, 4-(3-tri-fluoromethylhenylsulfonamido)phenyl, 3-(3-trifluoromethylphenylsulfonamido)phenyl, 4-(4-trifluoromethylphenylsulfonamido)phenyl, 3-(4-trifl uoromethylphenylsulfonamido)phenyl, 4- (4-trifluoro-methoxyphenylsulfonamido)phenyl, 3-(4-trifluoromethoxy-phenysulfonamido)phel, 4-(3methyl-phenylsulfonamido)phenyl, 3-(3-rnethylphenylsulfonarnido)phenyl, 4-(3,4-dimethoxyphenylsulfonamido)phenyl, 3-(3,4-dimethoxyphenylsulfonamido)phenyl, 4-(4-cyanophenylsuifonamido)phenyl, 3-(4-cyanophenyl-sulfonamido)phenyl, 4-(3-cyano-phenylsulfonamido)phenyl, 3-(3-cyanophenylsulfonamido)phenyl, 4-(3-chloro-4-methylphenylsulfonamido)phenyl, 3-(3-chloro-4-methylphenylsulfonamido)phenyl, 4-(4-biphenylsulfonamido)phenyl, 3-(4-biphenylsulfonamido)phenyl, 4-(4-isopropylphenylsulfonamido)phenyl, 3-(4-isopropylphenylsulfonamido)phenyl, 4-(naphth-1 -ylsulfolamido)phenyl, 3-(naphth-1-ylsulfonamido)phenyl, 4-(naphth-2-ylsulfonamido)phenyl, 3-(naphth-2-yisulfoflamido)-ph enyl, 4-benzylphenyl, 4-biphenyl, 4-trifluoromethoxyphenyl, 3-trifluoromethoxyphenyl, 2-trifluoromethoxyphenyl, 4-methanesulfonyiphenyl, 3-methanesulfonyiphenyl, 2-methanesulfonylpheflyl, 4- (4-methoxycarbonylphenylsulfonamido)phelyI or (N-methyl-4-p-toluenesulfonamido)phenyl.

SI h B580WOO 03974 Compounds of the formula I to be emphasized are those in which R1 is hydroxyl, 1-4C-alkoxy, 3-7C-cycloalkoxy, 3-7C-cycloalkylmethoxy or 1-4C-alkoxy which is completely or partially substituted by fluorine, R2 is hydroxyl, 1-4C-alkoxy, 3-7C-cycloalkoxy, 3-7C-cycloalkylmethoxy or 1-4C-alkoxy which is completely or partially substituted by fluorine, or in which R1 and R2 together are a 1-2C-alkylenedioxy group, R3 is hydrogen or 1-4C-alkyl, R31 is hydrogen or 1-4C-alkyl, or in which R3 and R31 together are a 1-4C-alkylene group, R4 is hydrogen or 1-4C-alkyl, is hydrogen, R51 is hydrogen, or in which and R51 together are an additional bond, R6 is a pyridyl radical which is substituted by R61 or a phenyl radical which is substituted by R7 and R8, where R61 is hydrogen, hydroxyl, halogen, 1-4C-alkoxy, 1-4C-alkyl, carboxyl, trifluoromethyl, 1-4C-alkoxycarbonyl or 1-4C-alkoxy which is completely or partially substituted by fluorine, R7 is hydroxyl, halogen, cyano, 1-4C-alkyl, 1-4C-alkoxy, 1-4C-alkylcarbonyloxy, trifluoromethyl, phenyl, phenyl-1-4C-alkyl, nitro, amino or N(R71)R72, where R71 is hydrogen, 1-4C-alkyl, SO 2 -R9 or S0 2 -R10 and R72 is 1-4C-alkyl, 1-4C-alkylcarbonyl or SO2-R10, R8 is hydrogen, hydroxyl, halogen, 1-4C-alkoxy or 1-4C-alkyl, and where R9 and R10 independently of one another are 1-4C-alkyl, phenyl, phenyl-1-4C-alkyl or phenyl which is substituted by one or more identical or different substituents, the substituents being selected from the group consisting of nitro, 1-4C-alkyl, halogen, 1-4C-alkylcarbonylamino, 1-4C-alkoxy, 1-4C-alkoxy which is completely or partially substituted by fluorine, cyano, phenyl, naphthyl and trifluoromethyl, and the salts of these compounds.

An embodiment [embodiment of the compounds according to the invention are compounds of the formula I, in which R1 is hydroxyl, 1-4C-alkoxy, 3-7C-cycloalkoxy, 3-7C-cycloalkylmethoxy or 1-4C-alkoxy which is completely or partially substituted by fluorine, R2 is hydroxyl, 1-4C-alkoxy, 3-7C-cycloalkoxy, 3-7C-cycloalkylmethoxy or 1-4C-alkoxy which is completely or partially substituted by fluorine, B580WOO 03974 6 or in which R1 and R2 together are a 1-2C-alkylenedioxy group, R3 is hydrogen or 1-4C-alkyl, R31 is hydrogen or 1-4C-alkyl, or in which R3 and R31 together are a 1-4C-alkylene group, R4 is hydrogen or 1-4C-alkyl, is hydrogen, R51 is hydrogen, or in which and R51 together are an additional bond, R6 is a pyridyl radical which is substituted by R61, where R61 is hydrogen, hydroxyl, halogen, 1-4C-alkoxy, 1-4C-alkyl, carboxyl, trifluoromethyl, 1-4C-alkoxycarbonyl or 1-4C-alkoxy which is completely or partially substituted by fluorine, and the salts of these compounds.

Compounds of embodiment a) to be emphasized are compounds of the formula I in which R1 is 1-4C-alkoxy, 3-7C-cycloalkoxy, 3-7C-cycloalkylmethoxy or 1-2C-alkoxy which is completely or partially substituted by fluorine, R2 is 1-4C-alkoxy, 3-7C-cycloalkoxy, 3-7C-cycloalkylmethoxy or 1-2C-alkoxy which is completely or partially substituted by fluorine, R3 is hydrogen, R31 is hydrogen, or in which R3 and R31 together are a 1-2C-alkylene group, R4 is hydrogen or 1-4C-alkyl, is hydrogen, R51 is hydrogen, or in which and R51 together are an additional bond, R6 is a pyridyl radical which is substituted by R61, where R61 is hydrogen, hydroxyl, halogen or 1-4C-alkoxy, and the salts of these compounds.

Compounds of embodiment a) particularly to be emphasized are compounds of the formula I in which R1 is 1-4C-alkoxy, 3-7C-cycloalkoxy or 1-2C-alkoxy which is completely or partially substituted by fluorine, R2 is 1-4C-alkoxy, 3-7C-cycloalkoxy or 1-2C-alkoxy which is completely or partially substituted by k fluorine, Sf(1 B580WOO 03974 7 R3 is hydrogen, R31 is hydrogen, or in which R3 and R31 together are a 1-2C-alkylene group, R4 is hydrogen or 1-4C-alkyl, is hydrogen, R51 is hydrogen, or in which and R51 together are an additional bond, R6 is a pyridyl radical which is substituted by R61, where R61 is hydrogen, hydroxyl, halogen or 1-4C-alkoxy, and the salts of these compounds.

Preferred compounds of embodiment a) are compounds of the formula I in which R1 is 1-4C-alkoxy, R2 is 1-4C-alkoxy, R3 is hydrogen, R31 is hydrogen, R4 is hydrogen, is hydrogen, R51 is hydrogen, R6 is a pyridyl radical which is substituted by R61, where R61 is hydrogen, hydroxyl or halogen, and the salts of these compounds.

Another embodiment [embodiment of the compounds according to the invention are those compounds of the formula I in which R1 is hydroxyl, 1-4C-alkoxy, 3-7C-cycloalkoxy, 3-7C-cycloalkylmethoxy or 1-4C-alkoxy which is completely or partially substituted by fluorine, R2 is hydroxyl, 1-4C-alkoxy, 3-7C-cycloalkoxy, 3-7C-cycloalkylmethoxy or 1-4C-alkoxy which is completely or partially substituted by fluorine, or in which R1 and R2 together are a 1-2C-alkylenedioxy group, R3 is hydrogen or 1-4C-alkyl, R31 is hydrogen or 1-4C-alkyl, or in which R3 and R31 together are a 1-4C-alkylene group, R4 is hydrogen or 1-4C-alkyl, is hydrogen, I f< B580WOO 03974 8 R51 is hydrogen, or in which and R51 together are an additional bond, R6 is a phenyl radical which is substituted by R7 and R8, where R7 is hydroxyl, halogen, cyano, 1-4C-alkyl, 1-4C-alkoxy, 1-4C-alkylcarbonyloxy, trifluoromethyl, phenyl, phenyl-1-4C-alkyl, nitro, amino or N(R71)R72, where R71 is hydrogen, 1-4C-alkyl, S0 2 -R9 or SO2-R10 and R72 is 1-4C-alkyl, 1-4C-alkylcarbonyl or S0 2 R8 is hydrogen, hydroxyl, halogen, 1-4C-alkoxy or 1-4C-alkyl and where R9 and R10 independently of one another are 1-4C-alkyl, phenyl, phenyl-1-4C-alkyl or phenyl which is substituted by one or more identical or different substituents, the substituents being selected from the group consisting of nitro, 1-4C-alkyl, halogen, 1-4C-alkylcarbonylamino, 1-4C-alkoxy, 1-4C-alkoxy which is completely or partially substituted by fluorine, cyano, phenyl, naphthyl and trifluoromethyl, and the salts of these compounds.

Compounds of embodiment b) to be emphasized are compounds of the formula I in which R1 is 1-4C-alkoxy, 3-7C-cycloalkoxy, 3-7C-cycloalkylmethoxy or 1-2C-alkoxy which is completely or partially substituted by fluorine, R2 is 1-4C-alkoxy, 3-7C-cycloalkoxy, 3-7C-cycloalkylmethoxy or 1-2C-alkoxy which is completely or partially substituted by fluorine, R3. is hydrogen, R31 is hydrogen, or in which R3 and R31 together are a 1-4C-alkylene group, R4 is hydrogen or 1-4C-alkyl, is hydrogen, R51 is hydrogen, or in which and R51 together are an additional bond, R6 is a phenyl radical which is substituted by R7 and R8, where R7 is hydroxyl, halogen, 1-4C-alkyl, 1-4C-alkoxy, 1-4C-alkylcarbonyloxy, trifluoromethyl, phenyl, phenyl-1-4C-alkyl, nitro, amino or N(R71)R72, where R71 is hydrogen, 1-4C-alkyl, S0 2 -R9 or S0 2 -R10 and R72 is 1-4C-alkyl, 1-4C-alkylcarbonyl or S0 2 R8 is hydrogen, hydroxyl, halogen, 1-4C-alkoxy or 1-4C-alkyl and where B580WOO 03974 9 R9 and R10 independently of one another are 1-4C-alkyl, phenyl or phenyl which is substituted by a substituent, the substituent being selected from the group consisting of nitro, 1-4C-alkyl, halogen and trifluoromethyl, and the salts of these compounds.

Compounds of embodiment b) particularly to be emphasized are compounds of the formula I in which R1 is 1-4C-alkoxy, 3-7C-cycloalkoxy or 1-2C-alkoxy which is completely or partially substituted by fluorine, R2 is 1-4C-alkoxy, 3-7C-cycloalkoxy or 1-2C-alkoxy which is completely or partially substituted by fluorine, R3 is hydrogen, R31 is hydrogen, or in which R3 and R31 together are a 1-4C-alkylene group, R4 is hydrogen or 1-4C-alkyl, is hydrogen, R51 is hydrogen, or in which and R51 together are an additional bond, R6 is a phenyl radical which is substituted by R7 and R8, where R7 is hydroxyl, halogen, 1-4C-alkoxy, 1-4C-alkylcarbonyloxy, phenyl, phenyl-1-4C-alkyl, nitro, amino or N(R71)R72, where R71 is hydrogen, S0 2 -R9 or SO 2 -R10 and R72 is 1-4C-alkylcarbonyl or S0 2 R8 is hydrogen, halogen or 1-4C-alkoxy and where R9 and R10 independently of one another are phenyl or phenyl which is substituted by a substituent, the substituent being selected from the group consisting of nitro, 1-4C-alkyl, halogen and trifluoromethyl, and the salts of these compounds.

Preferred compounds of embodiment b) are compounds of the formula I in which R1 is 1-4C-alkoxy or 3-7C-cycloalkoxy, R2 is 1-4C-alkoxy or 3-7C-cycloalkoxy, R3 is hydrogen, R31 is hydrogen, or in which R3 and R31 together are a 1-2C-alkylene group, ,R4 is hydrogen or 1-4C-alkyl, SI B580WOO 03974 is hydrogen, R51 is hydrogen, or in which and R51 together are an additional bond, R6 is a phenyl radical which is substituted by R7 and R8, where R7 is hydroxyl, halogen, 1-4C-alkoxy, 1-4C-alkylcarbonyloxy, phenyl, phenyl-1-4C-alkyl, nitro, amino or N(R71)R72, where R71 is hydrogen or S0 2 -R10 and R72 is 1-4C-alkylcarbonyl or SO 2 R8 is hydrogen, halogen or 1-4C-alkoxy and where is phenyl which is substituted by a substituent, the substituent being selected from the group consisting of nitro and 1-4C-alkyl, and the salts of these compounds.

An embodiment [embodiment of the compounds according to the invention are those compounds of the formula I in which R1 is hydroxyl, 1-4C-alkoxy, 3-7C-cycloalkoxy, 3-7C-cycloalkylmethoxy or 1-4C-alkoxy which is completely or partially substituted by fluorine, R2 is hydroxyl, 1-4C-alkoxy, 3-7C-cycloalkoxy, 3-7C-cycloalkylmethoxy or 1-4C-alkoxy which is completely or partially substituted by fluorine, or in which R1 and R2 together are a 1-2C-alkylenedioxy group, R3 is hydrogen or 1-4C-alkyl, R31 is hydrogen or 1-4C-alkyl, or in which R3 and R31 together are a 1-4C-alkylene group, R4 is hydrogen or 1-4C-alkyl, is hydrogen, R51 is hydrogen, or in which and R51 together are an additional bond, R6 is a phenyl radical which is substituted by R7 and R8, where R7 is hydroxyl, halogen, cyano, 1-4C-alkyl, 1-4C-alkoxy, 1-4C-alkylcarbonyloxy, trifluoromethyl, phenyl, phenyl-l-4C-alkyl, nitro, amino, 1-4C-alkoxy which is completely or partially substituted by fluorine, or is S0 2 -R70 or N(R71)R72, where is 1-4C-alkyl, R71 is hydrogen, 1-4C-alkyl, S0 2 -R9 or S0 2 -R10 and R72 is 1-4C-alkyl, 1-4C-alkylcarbonyl or S0 2 I e "I B580WOO 03974 11 R8 is hydrogen, hydroxyl, halogen, 1-4C-alkoxy or 1-4C-alkyl and where R9 and R10 independently of one another are 1-4C-alkyl, phenyl, phenyl-1-4C-alkyl or phenyl which is substituted by one or more identical or different substituents, the substituents being selected from the group consisting of nitro, 1-4C-alkyl, halogen, 1-4C-alkylcarbonylamino, 1-4C-alkoxy, 1-4C-alkoxy which is completely or partially substituted by fluorine, cyano, phenyl, naphthyl, trifluoromethyl and 1-4C-alkoxycarbonyl, and the salts of these compounds.

Compounds of embodiment c) to be emphasized are those compounds of the formula I in which R1 is 1-4C-alkoxy, 3-7C-cycloalkoxy, 3-7C-cycloalkylmethoxy or 1-2C-alkoxy which is completely or partially substituted by fluorine, R2 is 1-4C-alkoxy, 3-7C-cycloalkoxy, 3-7C-cycloalkylmethoxy or 1-2C-alkoxy which is completely or partially substituted by fluorine, R3 is hydrogen, R31 is hydrogen, or in which R3 and R31 together are a 1-4C-alkylene group, R4 is hydrogen or 1-4C-alkyl, is hydrogen, R51 is hydrogen, or in which and R51 together are an additional bond, R6 is a phenyl radical which is substituted by R7 and R8, where R7 is hydroxyl, halogen, cyano, 1-4C-alkyl, 1-4C-alkoxy, 1-4C-alkylcarbonyloxy, trifluoromethyl, phenyl, phenyl-1-4C-alkyl, nitro, amino, 1-4C-alkoxy which is completely or partially substituted by fluorine, or is S0 2 -R70 or N(R71)R72, where is 1-4C-alkyl, R71 is hydrogen, 1-4C-alkyl, S0 2 -R9 or SO2-R10 and R72 is 1-4C-alkyl, 1-4C-alkylcarbonyl or S0 2 R8 is hydrogen, hydroxyl, halogen, 1-4C-alkoxy or 1-4C-alkyl and where R9 and R10 independently of one another are 1-4C-alkyl, phenyl or phenyl which is substituted by a substituent, the substituent being selected from the group consisting of nitro, 1-4C-alkyl, halogen, trifluoromethyl and 1-4C-alkoxycarbonyl, and the salts of these compounds.

B580WOO 03974 Compounds of embodiment c) particularly to be emphasized are those compounds of the formula I in which R1 is 1-4C-alkoxy, 3-7C-cycloalkoxy or 1-2C-alkoxy which is completely or partially substituted by fluorine, R2 is 1-4C-alkoxy, 3-7C-cycloalkoxy or 1-2C-alkoxy which is completely or partially substituted by fluorine, R3 is hydrogen, R31 is hydrogen, or in which R3 and R31 together are a 1-2C-alkylene group, R4 is hydrogen or 1-4C-alkyl, is hydrogen, R51 is hydrogen, or in which and R51 together are an additional bond, R6 is a phenyl radical which is substituted by R7 and R8, where R7 is hydroxyl, halogen, cyano, 1-4C-alkoxy, 1-4C-alkylcarbonyloxy, trifluoromethyl, phenyl, phenyl-1-4C-alkyl, nitro, amino, 1-4C-alkoxy which is completely or partially substituted by fluorine, or is S0 2 -R70 or N(R71)R72, where is 1-4C-alkyl, R71 is hydrogen, 1-4C-alkyl, S0 2 -R9 or S0 2 -R10 and R72 is 1-4C-alkylcarbonyl or S0 2 R8 is hydrogen, halogen or 1-4C-alkoxy and where R9 and R10 independently of one another are phenyl or phenyl which is substituted by a substituent, the substituent being selected from the group consisting of nitro, 1-4C-alkyl, halogen, trifluoromethyl and 1-4C-alkoxycarbonyl, and the salts of these compounds.

Preferred compounds of embodiment c) are those compounds of the formula I in which R1 is 1-4C-alkoxy or 3-7C-cycloalkoxy, R2 is 1-4C-alkoxy or 3-7C-cycloalkoxy, R3 is hydrogen, R31 is hydrogen, or in which R3 and R31 together are a 1-2C-alkylene group, R4 is hydrogen or 1-4C-alkyl, is hydrogen, R51 is hydrogen, B580WOO 03974 13 or in which and R51 together are an additional bond, R6 is a phenyl radical which is substituted by R7 and R8, where R7 is hydroxyl, halogen, cyano, 1-4C-alkoxy, 1-4C-alkylcarbonyloxy, trifluoromethyl, phenyl, phenyl-1-4C-alkyl, nitro, amino, 1-4C-alkoxy which is completely or partially substituted by fluorine, or is S0 2 -R70 or N(R71)R72, where is 1-4C-alkyl, R71 is hydrogen, 1-4C-alkyl or S0 2 -R10 and R72 is 1-4C-alkylcarbonyl or S0 2 -R1 0, R8 is hydrogen, halogen or 1-4C-alkoxy and where is phenyl which is substituted by a substituent, the substituent being selected from the group consisting of nitro, 1-4C-alkyl and 1-4C-alkoxycarbonyl, and the salts of these compounds.

Particularly preferred compounds of the formula I are those in which R1 is 1-4C-alkoxy or 3-7C-cycloalkoxy, R2 is 1-4C-alkoxy or 3-7C-cycloalkoxy, R3 is hydrogen, R31 is hydrogen, R4 is hydrogen or 1-4C-alkyl, is hydrogen, R51 is hydrogen, or in which and R51 together are an additional bond, R6 is a phenyl radical which is substituted by R7 and R8, where R7 is N(R71)R72, where R71 is hydrogen, S0 2 -R9 or S0 2 -R10 and R72 is 1-4C-alkyl, 1-4C-alkylcarbonyl or S0 2 R8 is hydrogen and where R9 and R10 independently of one another are phenyl which is substituted by a substituent, the substituents being selected from the group consisting of nitro, 1-4C-alkyl and 1-4C-alkoxycarbonyl, and the salts of these compounds.

Suitable salts for compounds of the formula I depending on substitution are all acid addition salts or salts with bases. Particular mention may be made of the pharmacologically tolerable salts of the inorganic and organic acids and bases customarily used in pharmacy. Those suitable are, on the one hand, water-soluble and water-insoluble acid addition salts with acids such as, for example, hydrochloric acid, B580WOO 03974 14 hydrobromic acid, phosphoric acid, nitric acid, sulfuric acid, acetic acid, citric acid, D-gluconic acid, benzoic acid, 2-(4-hydroxybenzoyl)benzoic acid, butyric acid, sulfosalicylic acid, maleic acid, lauric acid, malic acid, fumaric acid, succinic acid, oxalic acid, tartaric acid, embonic acid, stearic acid, toluenesulfonic acid, methanesulfonic acid or 3-hydroxy-2-naphthoic acid, the acids being employed in salt preparation depending on whether it is a mono- or polybasic acid and depending on which salt is desired in an equimolar quantitative ratio or one differing therefrom.

On the other hand, salts with bases are also suitable. Examples of salts with bases which may be mentioned are alkali metal (lithium, sodium, potassium) or calcium, aluminum, magnesium, titanium, ammonium, meglumine or guanidinium salts, where here, too, the bases are employed in salt preparation in an equimolar quantitative ratio or one differing therefrom.

Pharmacologically intolerable salts which can initially be obtained, for example, as process products in the preparation of the compounds according to the invention on an industrial scale, are converted into pharmacologically tolerable salts by processes known to the person skilled in the art.

The compounds of the formula I are chiral compounds having chiral centers in positions 4a and and, depending on the meaning of the substituents R3, R31, R4, R5 and R51, further chiral centers in positions 1, 2, 3 and 4. The invention therefore includes all conceivable pure diastereomers and pure enantiomers and their mixtures in any mixing ratio, including the racemates. The compounds of the formula I are preferred in which the hydrogen atoms in the positions 4a and 10b are cis to one another.

The pure cis diastereomers and the pure cis enantiomers are particularly preferred in this case, and their mixtures in any mixing ratio and including the racemates.

The enantiomers can be separated in a manner known per se (for example by preparation and separation of corresponding diastereoisomeric compounds). A resolution of enantiomers is preferably carried out at the stage of the starting compounds of the formula III (see attached formula sheet), for example via salt formation of the racemic compounds of the formula Ill with optically active carboxylic acids.

Alternatively, enantiomerically pure starting compounds of the formula III can also be prepared by means of asymmetric syntheses.

The invention further relates to a process for the preparation of the compounds of the formula I, in which R1, R2, R3, R31, R4, R5, R51 and R6 have the meanings indicated above, and their salts. The process comprises a) cyclocondensing appropriate compounds of the formula II (see attached formula sheet), in which R1, R2, R3, R31, R4, R5, R51 and R6 have the meanings indicated above, or 1 B580WOO 03974 b) for the preparation of compounds of the formula I in which R1, R2, R3, R31, R4, R5 and R51 have the meanings indicated above and R6 is pyridyl substituted by R61, where R61 is hydroxyl, hydrolyzing appropriate compounds of the formula I in which R1, R2, R3, R31, R4, and R51 have the meanings indicated above and R6 is pyridyl substituted by R61, where R61 is halogen, or c) for the preparation of compounds of the formula I in which R1, R2, R3, R31, R4, R5 and R51 have the abovementioned meanings and R6 is a phenyl radical which is substituted by R7 and R8, where R7 is amino, reducing corresponding compounds of the formula I in which R7 is nitro, or d) for the preparation of compounds of the formula I in which R1, R2, R3, R31, R4, R5 and R51 have the abovementioned meanings and R6 is a phenyl radical which is substituted by R7 and R8, where R7 is hydroxyl, hydrolyzing corresponding compounds of the formula I in which R7 is 1-4C-alkylcarbonyloxy, or e) N-acylating compounds of the formula I in which R1, R2, R3, R31, R4, R5 and R51 have the abovementioned meanings and R6 is a phenyl radical which is substituted by R7 and R8, where R7 is amino, with a suitably activated 1-4C-alkylcarbonyl derivative, or f) reacting compounds of the formula I in which R1, R2, R3, R31, R4, R5 and R51 have the abovementioned meanings and R6 is a phenyl radical which is substituted by R7 and R8, where R7 is amino, with a sulfonic acid compound of the formula X-S0 2 -R10, in which R10 has the abovementioned meaning and X is a suitable leaving group, or g) N-acylating compounds of the formula I in which R1, R2, R3, R31, R4, R5 and R51 have the abovementioned meanings and R6 is a phenyl radical which is substituted by R7 and R8, where R7 is the group N(H)R72, where R72 has the meaning 1-4C-alkylcarbonyl or S0 2 with a suitably activated 1-4C-alkylcarbonyl derivative, N-alkylating with a suitably activated 1- 4C-alkyl derivative or reacting with a sulfonic acid compound of the formula X-S0 2 -R9 or X-

SO

2 -R10, in which R9 and R10 have the abovementioned meanings and X is a suitable leaving group, and, if desired, then converting compounds of the formula I obtained according to f) or g) into their salts, or, if desired, then converting salts of the compounds of the formula I obtained according to f) or g) into the free compounds.

The cyclocondensation according to process variant a) is carried out in a manner known per se to the person skilled in the art according to Bischler-Napieralski as described in J.Chem.Soc., 1956, B580WO00 0974 16 4280-4282) in the presence of a suitable condensing agent, such as, for example, polyphosphoric acid, phosphorus pentachloride, phosphorus pentoxide or preferably phosphorus oxytrichloride, in a suitable inert solvent, e.g. in a chlorinated hydrocarbon such as chloroform, or in a cyclic hydrocarbon such as toluene or xylene, or another inert solvent such as acetonitrile, or without further solvent using an excess of condensing agent, preferably at elevated temperature, in particular at the boiling temperature of the solvent or condensing agent used.

The hydrolysis of compounds of the formula I in which R61 is halogen, in particular bromineor chlorine, according to variant b) is likewise carried out in a manner known to the person skilled in the art as described in Helv.Chim.Acta 1942, 25, 1485), in a suitable solvent and in the presence or absence of water, by reaction with one or more suitable bases, at reaction temperatures between 0°C and the boiling temperature of the solvent used.

Suitable bases are, for example, metal carbonates such as potassium and sodium carbonate and metal hydroxides such as potassium and sodium hydroxide, a combination of metal carbonate and metal hydroxide preferably being used when conducting the reaction with exclusion of water. If desired, when using an organic solvent the conduct of the reaction can be improved by addition of a complexing reagent as described in Tetrahedron 1987, 43, 2557).

The reduction of the nitro compounds analogously to variant c) is expediently carried out by catalytic hydrogenation, for example using Raney nickel and molecular hydrogen or another hydrogen source such as hydrazine, using base metals such as tin, zinc and iron (preferably in acidic solution), electrolytically or using other suitable reductants, in a suitable solvent, e.g. in water or an alcohol such as methanol or ethanol and, if desired, in the presence of an acid such as, for example, hydrochloric acid.

Reduction with iron and hydrochloric acid, e.g. as described in the examples, is particularly preferred.

Hydrolysis according to variant d) is likewise carried out in a manner known to the person skilled in the art, preferably under basic conditions, for example using a base such as potassium hydroxide in a suitable solvent, e.g. an alcohol such as methanol, and in the presence or absence of water.

N-Acylation according to variant e) is carried out in a manner as is known for the preparation of amides.

Suitably activated 1-4C-alkylcarbonyl derivatives are, for example, corresponding acids, esters, azides and in particular anhydrides and halides (preferably chlorides and bromides).

If desired, the reaction can be carried out in the presence of a suitable base, e.g. of an alkali metal carbonate such as potassium carbonate, of an alkali metal hydroxide such as sodium hydroxide or of a nitrogen base such as pyridine, triethylamine or ethyldiisopropylamine and/or employing an excess of amine of the formula I. Alternatively, the reaction can also be carried out without base, where de- B580WOO 03974 17 pending on the nature of the starting compounds if appropriate the acid addition salts can first be separated off in particularly pure form.

Suitable solvents which may be mentioned for the acylation are solvents such as dimethyl sulfoxide, acetone, tetrahydrofuran, dimethylformamide or acetonitrile, or alternatively chlorinated hydrocarbons such as methylene chloride. If desired, the reaction can also be carried out without additional solvent using an excess of acylating agent and/or base as the solvent.

The preparation of sulfonamides of the formula I according to the invention according to variant f) is carried out in a manner as is known for the synthesis of sulfonamides, for example analogously to the N-acylation according to variant Preferred sulfonic acid derivatives of the formula X-S0 2 -R10 which are used in this case are those in which X is a suitable leaving group such as, for example, halogen, in particular chlorine.

Depending on whether compounds of the formula I in which R7 is N(H)S0 2 -R10 or N(S0 2 -R10) 2 are the desired product, the sulfonic acid derivative of the formula X-S0 2 -R10 is employed in an equimolar quantitative ratio or one differing therefrom.

The reaction according to variant g) can likewise be carried out in a manner known to the person skilled in the art, for example analogously to variant e) or The compounds of the formula I in which R7 is the group N(H)R72, where R72 has the meaning 1-4C-alkylcarbonyl or S0 2 -R10, can in this case be employed as such or preferably in the form of their salts with bases, e.g. in the form of the alkali metal salts (in particular as the sodium salt). Expediently, the salt is produced from the corresponding free compounds of the formula I immediately before the reaction by deprotonation using a suitable base, for example using a metal hydride such as sodium hydride, in a preferably aprotic dipolar solvent such as dimethylformamide or tetrahydrofuran.

The substances according to the invention are isolated and purified in a manner known per se, e.g. by distilling off the solvent in vacuo and recrystallizing the resulting residue from a suitable solvent or subjecting it to one of the customary purification methods, such as, for example, column chromatography on suitable support material.

Salts are obtained by dissolving the free compound in a suitable solvent, e.g. a chlorinated hydrocarbon, such as methylene chloride or chloroform, or a low molecular weight aliphatic alcohol (ethanol, isopropanol) which contains the desired acid or base, or to which the desired acid or base is then added. The salts are obtained by filtering, reprecipitating, precipitating using a nonsolvent for the addition salt or by evaporation of the solvent. Salts obtained can be converted by alkalization or by acidification into the free compounds, which in turn can be converted into salts. In this manner, pharmacologically intolerable salts can be converted into pharmacologically tolerable salts.

B580WO 03974 18 Compounds of the formula II (see attached formula sheet) in which R1, R2, R3, R31, R4, R5, R51 and R6 have the meanings indicated above are accessible from the corresponding compounds of the formula III (see attached formula sheet) in which R1, R2, R3, R31, R4, R5 and R51 have the meanings indicated above, by reaction with compounds of the formula R6-CO-X, in which R6 has the meaning indicated above and X is a suitable leaving group, preferably a chlorine atom. For example, the acylation or benzoylation is carried out as described in the following examples or as in J.Chem. Soc.(C), 1971,1805-1808.

Compounds of the formula R6-CO-X and compounds of the formula III are either known or can be prepared in a known manner.

The compounds of the formula III can be prepared from compounds of the formula IV (see attached formula sheet) in which R1, R2, R3, R31, R4, R5 and R51 have the abovementioned meanings, by reduction of the nitro group.

Reduction is carried out in a manner known to the person skilled in the art, for example as described in J.Org.Chem. 1962, 27, 4426 or as described in the following examples. Preferably, the reduction is carried out by catalytic hydrogenation, e.g. in the presence of Raney nickel, in a lower alcohol such as methanol or ethanol at room temperature and at normal or elevated pressure. If desired, a catalytic amount of an acid, such as, for example, hydrochloric acid, can be added to the solvent.

The compounds of the formula IV (see attached formula sheet) in which R1, R2, R3, R31 and R4 have the meanings indicated above and R5 and R51 are hydrogen, are either known or can be prepared from corresponding compounds of the formula IV in which R5 and R51 together are an additional bond.

The reaction can be carried out in a manner known to the person skilled in the art, preferably by hydrogenation in the presence of a catalyst, such as, for example, palladium on active carbon, e.g. as described in J.Chem.Soc.(C), 1971, 1805-1808 or as in the following examples.

The compounds of the formula IV in which R5 and R51 together are an additional bond are either known or can be obtained by reaction of compounds of the formula V (see attached formula sheet), in which R1 and R2 have the abovementioned meanings, with compounds of the formula VI (see attached formula sheet), in which R3, R31 and R4 have the abovementioned meanings.

The cycloaddition is in this case carried out in a manner known to the person skilled in the art according to Diels-Alder, e.g. as described in J.Amer.Chem.Soc. 1957, 79, 6559 or in J.Org.Chem. 1952, 17, 581 or as in the following examples.

Compounds of the formula IV obtained in the cycloaddition, in which the phenyl ring and the nitro group are trans to one another, can be converted into the corresponding cis compounds in a manner known 19 to the person skilled in the art, e.g. as described in J.

Amer.Chem.Soc. 1957, 79, 6559 or as in the following examples.

The compounds of the formulae VI and V are either known or can be prepared in a known manner. The compounds of the formula V can be prepared, for example, in a manner known to the person skilled in the art from corresponding compounds of the formula VII, as described, for example, in J.Chem.Soc. 1951, 2524 or in J.Org.Chem. 1944, 9, 170 or as in the following examples.

The compounds of the formula VII (see attached formula sheet) in which R1 and R2 have the meanings indicated above are either known or can be prepared in a manner known to the person skilled in the art, as described, for example, in Ber.Dtsch.Chem. Ges. 1925, 58, 203 or as in the following examples.

20 The following examples serve to illustrate the invention in greater detail without restricting it. Likewise, further compounds of the formula I whose preparation is not explicitly described can be prepared in an analogous manner or in a manner familiar to the person skilled in the art 25 per se using customary process techniques.

o* In the examples, m.p. stands for melting point, b.p. for boiling point, h for hour(s), RT for room temperature, EF for empirical formula, MW for molecular weight, calc. for calculated, fnd for found. The compounds and their salts mentioned in the examples are a preferred subject of the invention.

For the purposes of this specification it will be clearly understood that the word "comprising" means "including but not limited to", and that the word "comprises" has a corresponding meaning.

H:\Emma\Keep\Specis\22910.97.doc 16/02/00 19 B580W00 03974 Examples Final products 1. (+/-)-cs-89-Dimethoxy-6-(4-p-toluenesufoflaidophelvi)-1 ,2,3,4,4a,1Obhexahydrophenanthridine g of (+/-)-cis-N-[2-(3,4-dimethoxyphenyl)cyclohexyl]-4-p-tolueflesulfoflamidobeflzamide are dissolved in 100 ml of acetonitrile and 1.0 ml of phosphorus oxychioride and the solution is stirred at 50 0

.C

for 8 h. The reaction mixture is added to 100 ml of saturated sodium hydrogencarbonate solution and extracted with ethyl acetate. The organic phase is washed with sodium hydrogencarbonate solution and water, dried using sodium sulfate and concentrated. The residue is recrystallized from ethanol. 1.8 g (53.2% of theory) of the title compound of melting point: 122'C (decomposition) are obtained.

EF: C 28

H

30

M

2 0 4 S; MW: 490.63 Elemental analysis: calc.: C 68.54 H 6.16 N 5.71 5 6.53 fnd: C 68.35 H 6.24 N 5.55 S 6.47 Starting from the starting compounds described below, the following are obtained according to the procedure as in Example 1: 2. 1+-)cis8,9Diethoxy-6-(4-p-toluenesulfonamidophelvi)-1 ,2,3,4,4a.1 Obhexahydrophenanthridine 110-11 5 0 C, yield 42.4% of theory EF: C 30 H34N 2 0 4 S; MW: 518.68 Elemental analysis: calc.: C 68.99 H 6.64 N 5.36 S 6.14 fnd: C 69.04 H 6.58 N 5.28 S 6.12 3. (+I-)-cis-9-Cvclopentvloxv-8-methox-6-(4-,-toluelesufofamidophelV)-1 ,2,3,4,4a.1Obhexahvdrophenanthridine 17500, yield 62.5% of theory EF: C 32

H

36

N

2 0 4 S; MW: 544.72 Elemental analysis: calc.: C 70.56 H 6.66 N 5.14 S 5.89 fnd: C 70.09 H 6.72 N 5.05 S 5.88 B580W00 03974 21 4. (+--i--ylpetlx--ehx-6(--ounslfnmd pe .)12,3.4,4a,1 Obhexahvdrophenanthridine 193-196 0 C, yield 38.9% of theory EF: C 32

H

36

N

2 0 4 S; MW: 544.72 Elemental analysis: :calc.: C 70.56 H 6.66 N 5.14 S 5.89 fnd: C 70.39 H 6.77 N 5.10 S 5.73 methoxy-6-(4-n itrophenyl)-1 ,2,3,4;4a,l 0 b-hexahyd roph en anth rid in e 182'C, yield 75.2% of theory EF: 021 H 22

N\

2 0 4 MW: 366.42 Elemental analysis: calc.: C 68.84 H 6.05 N 7.65 fnd: C 68.88 H 6.10 N 7.57 6. (+I-)-cis-8,9-Dimneth oxv-6-(2,6-d ich loroi'henv)-1 ,2,3,4,4a.1 Ob-h exahyd roph ena nth rid ine 174-175*C, yield 44.0% of theory EF: C 21

H-

21 C1\N0 2 MW: 390.31 Elemental analysis: calc.:C 64.62 H 5.42 Cl 18.17 N3.59 fnd:C 64.45 H 5.40 01 17.89 N3.62 7. is-8,9-Di meth oxy-6-(3,4-d imethoxvph eyl)-1 .2,3.4,4a.1 0Ob-hexahyd rophena nth ridi ne 160-162oC, yield 61.3% of theory EF: C 23

H

27 N0 4 MW: 381.48 Elemental analysis: calc.: C 72.42 H 7.13 N 3.67 fnd: C 72.38 H 7.00 N 3.53 8. (+/-)-cis-8,9-Dimethoxy-2,3-dimethI-6-(4--toluenesufoflaidohel-1 .4.4a~l~btetrahydrophenanthridine M.p. from 128 0 C (decomposition).

EF: C 30

H

32

N

2 0 4 S; MW: 516.66 Elemental analysis: (x 0.5 H 2 0): calc.: C 68.55 H 6.33 N 5.33 fnd: C 68.91 H 6.29 N 5.31 B580W00 013974 22 9. (+/-)-trans-8,9-Dimethoxy-6-(4-p-toluelesulfoflamidohell)-1 ,2,3,44a.1 Obhexalhydrophenanthridine hydrochloride 219-222 0 C, yield: 30.2% of theory EF: C 28

H

30

N

2 0 4 S x HCi x H 2 0; MW: 545.1 Elemental analysis: calc.: C 61 .70 H 6.10 Cl 6.50 N 5.14 S 5.88 fnd: C 61.94 H 6.00 Cl 6.79 N 5.15 S 5.83 (+/-)-trans-8,9-Dimethox-6-(4-p-toluenesulfonamidophelyl)-1 ,4,4a,1Obtetrahvdrophenanthridine hydrochloride 189-192'C, yield: 40.6% of theory EF: C 28

H

28

N

2 0 4 S x HCI x H 2 0; MW: 543.09 Elemental analysis: calc.: C 61.93 H 5.75 Cl 6.53 N 5.16 S 5.90 fnd: C 61.44 H 5.51 Cl 6.78 N 5.04 S 5.83 11. (+/-)-trans-8,9-Dimethoxy-2,3-dimethyl-6-(4-p-toluelesufoflamidophelvl)-1 .4,4a,1 Obtetrahvdrophenanthridine 200-203.5*C, yield: 54.2% of theory EF: C 30

H

32

N

2 0 4 S; MW: 516.66 Elemental analysis: calc.: C 69.74 H 6.24 N 5.42 S 6.21 fnd: C 69.67 H 6.37 N 5.37 S 6.02 12. (+I-)-trans-8,9-Dimethoxy-1 *4-ethano-6-(4-p-toluenesulfonamidophenyl)-1 .2,3,4,4a,1Obhexahydrophenanthridine >22000 (decomposition).

EF: C 30

H

32

N

2 0 4 S; MW: 516.66 13. (+I--cis-6-(4-Acetoxy Phenl)-8,9-d iethoxV-1.2.3',4,4a,1 0Ob-hexahyd roph en anth rid ife 99-1 01 0 C, yield: 31.3% of theory EF: C 25

H

29 N0 4 MW: 407.51 Elemental analysis: calc.: C 73.69 H 7.17 N 3.44 fnd: C 73.47 H 7.15 N 3.47 B580W00 03974 23 14. (+I-)-cis-6-(4-Benzvl Phenvyl)-8,9-d iethoxV-1 ,2,3,4,4a, I Ob-h exahyd roPh ena nth rid ine 135-137 0 C, yield: 65.1% of theory EF: C 30

H

33 N0 2 MW: 439.6 Elemental analysis: calc.:- C 81.97 H 7.56 N 3.18 fnd: C 81.93 H 7.54 N 3.43 phenVl-8,9-d iethoxV-1 .2,3,4,4a 10 Ob-h exahyd rophenanth rid ine 156-158*C, yield: 38.6% of theory EF: C 29

H-

31 N0 2 MW: 425.58 Elemental analysis: calc.: C 81.85 H 7.34 N 3.29 fnd: 0 81.69 H 7.34 N 3.17 16. 1+I)-cis-8,9-Diethoxv-6-(4-fluoro phenVl)-1 .2.3A44a .1 Ob-h exahyd ro phena nth rid ine 92-93*C, yield: 20.3% of theory EF: C 23

H

26 FN0 2 MW: 367.47.

Elemental analysis: cabc.: C 75.18 H 7.13 N 3.81 fnd: C 75.21 H 7.19 N 3.74 17. (+I-)-cis-8,9-Diethoxv-7-(4-trifluoromethylphenVl)-1,3,4,4a.1 Obhexahvdrophenanthridine Oil, yield: 27.5% of theory EF: C 24

H

26

F

3 N0 2 MW: 417.48 Elemental analysis: calc.: C 69.05 H 6.28 N 3.36 fnd: C 68.70 H 6.31 N 3.09 18. iethoxV-6-(4-cyanophenvl)-1 ,2,3.4,4a, I Ob-hexahyd rophenanth rid in e 125-127'C, yield: 59.9% of theory EF: C 24

H-

26

N

2 0 2 MW: 374.49 Elemental analysis: calc.: C 76.98 H 7.00 N 7.48 fnd: C076.92 H 7.15 N 7.37 B580W00 03974 24 19. (+I-)-cis-8,9-Diethoxy-6-(4-trifluoromethoxphenVl)-1 ,2.3,4,4a,1 Obhexahydrophenanthridine 98-100 0 C, yield: 23.4% of theory EF: C 24

H

2 6

F

3

N

3 MW: 433.48 Elemental analysis: caic.: C 66.50 H 6.05 N 3.23 fnd: C 66.44 H 6.05 N 3.18 (+/-)-cis-9-Ethox-8-methox-6-(4--toluenesulfonamidophenl)-1 ,2,3.4,4a,1 Obhexahydrophenanthridine 9500 yield: 51.0% of theory EF: C 29

H

32

N

2 0 4 S; MW: 504.65 Elemental analysis: calc.: C 69.02 H 6.39 N 5.55 fnd: C 69.19 H 6.68 N 5.44 21. (+I-)-cis-9-Ethoxy-8-methoxy-6-(4-n itrophfenyl)-1, 2,3,4,4a1 Ob-hexahyd rophenanth ridine 122-124*C, yield: 60.5% of theory EF: C 22

H

24

N

2 0 4 MW: 380.45 Elemental analysis: calc.: C 69.46 H 6.36 N 7.36 fnd: C 69.21 H 6.23 N 7.24 22. (+I-)-cis-9-Ethoxy-8-methoxv-6-(4-methanesulfoylphey)-1 .2,3,4.4a.1 Obhexahvdrophenanthridine 196-197*C, yield: 67.2% of theory EF: C 23

H

27 N0 4 MW: 413.54 Elemental analysis: cabc.: C 66.80 H 6.58 N 3.39 fnd: C 66.85 H 6.62 N 3.45 23. (+-)-cis-9-Ethoxy-8-methoxy-6-4-(4-methoxvcarbofylphenyl)sulfonamidophenyll 1.2,3,4,4a. Ob-hexahyd rophenanth ridine hdrochloride dec. from 210*C, yield: 55.6% of theory EF: C 30

H

32

N

2 0 6 S x HCI; MW: 585.12 Elemental analysis x 0.5 H 2 0: calc.: C 60.65 H 5.77 N 4.72 Cl 5.97 S 5.40 fnd: C 60.51 H 5.68 N 4.73 Cl 5.89 S 5.93 1 B580WOO 03974 24. (+/-)-cis-8,9-Diethoxy-6-(pvrid-4-yl)-1,2,3,4,4a,10b-hexahydrophenanthridine dihydrochloride 3.2 g of (+/-)-cis-N-[2-(3,4-diethoxyphenyl)cyclohexyl]-4-isonicotinamide are dissolved in 50 ml of acetonitrile and 3.0 ml of phosphorus oxychloride and the solution is stirred at 50 0 C for 8 h. The reaction mixture is added to 100 ml of saturated sodium hydrogencarbonate solution and extracted with ethyl acetate. The organic phase is washed with sodium hydrogencarbonate solution and water, dried using sodium sulfate and concentrated. The residue is chromatographed on silica gel using a mixture of toluene/dioxane/petroleum ether/triethylamine in the ratio 6:2:1:0.5. The product fractions are concentrated, the residue is dissolved in 30 ml of ethanol, and the solution is treated with 7 ml of diethyl ether saturated with hydrogen chloride gas and added dropwise to 400 ml of diethyl ether. The precipitate is filtered off with suction, washed with diethyl ether and dried. 1.6 g (43.4% of theory) of the title compound are obtained as the dihydrochloride of 223 0 C (dec.).

EF: C 22

H

26

N

2 0 2 x 2 HCI; MW: 423.39 Elemental analysis: calc.:C 57.52 H 5.42 Cl 18.17 N 3.59 fnd:C 57.09 H 5.40 Cl 17.89 N 3.62 Starting from the starting compounds described below, the following are obtained according to the procedure as in Example 24: (+/-)-cis-8,9-Diethoxv-6-(pyrid-3-yl)-1,2,3.4,4a,10b-hexahydrophenanthridine hydrochloride 233°C, yield 37.8% of theory EF: C 2 2

H

2 6

N

2 0 2 x HCI; MW: 386.93 Elemental analysis: calc.:C 68.29 H 7.03 Cl 9.16 N 7.24 fnd:C 68.43 H 7.09 CI 9.29 N 7.30 26. (+/-)-cis-8,9-Diethoxy-6-(2-chloropyrid-5-I)-1,2,3,4,4a,1 b-hexahydrophenanthridine The title compound is obtained by concentrating the product fractions after chromatography analogously to the procedure as in Example 24: 123-126 0 C, yield 75.7% of theory EF: C 22

H

25

CIN

2 0 2 MW: 384.91 Elemental analysis: calc.:C 68.01 H 6.59 Cl 9.13 N 7.21 A? fnd:C 68.04 H 6.45 Cl 9.26 N 7.16 I I.

B580WOO 03974 26 27. (+/-)-cis-8,9-Diethoxy-6-(2-hydroxypyrid-5-yl)-1,2,3,4,4a,10b-hexahydrophenanthridine 850 mg of (+/-)-cis-8,9-diethoxy-6-(2-chloropyrid-5-yl)-1,2,3,4,4a,10b-hexahydrophenanthridine are suspended in 60 ml of toluene, treated with 1.0 g of potassium carbonate, 2.0 g of potassium hydroxide and 0.26 mg of tris[2-(2-methoxyethoxy)ethyl]amine and refluxed overnight. The suspension is filtered, the solvent is removed in vacuo, the residue is taken up in water, and the mixture is neutralized with 0.1 M hydrochloric acid and extracted with ethyl acetate. The organic phase is dried using sodium sulfate, the solvent is removed in vacuo, and the precipitate which is deposited in the course of this is filtered off with suction and dried. 211-213°C, yield 12.3% of theory.

EF: C 22

H

26

N

2 0 3 MW: 366.46 Elemental analysis: calc.: C 72.11 H 7.15 N 7.64 fnd: C 72.55 H 7.10 N 7.58 28. (+/-)-cis-8,9-Dimethoxv-6-(4-aminophenyl)-1,2,3,4,4a,1 b-hexahydrophenanthridine g of (+/-)-cis-8,9-dimethoxy-6-(4-nitrophenyl)-1,2,3,4,4a,1 b-hexahydrophenanthridine are dissolved in 200 ml of methanol, and the solution is treated with 5 ml of concentrated hydrochloric acid, ml of water and 800 mg of iron powder and stirred overnight at RT. The reaction mixture is filtered, the filtrate is concentrated, the residue is extracted with sodium hydrogencarbonate solution/ethyl acetate, and the organic phase is dried using sodium sulfate and concentrated. The residue is chromatographed on silica gel using a mixture of toluene/dioxane/triethylamine in the ratio 40:20:2. After concentration of the corresponding eluate fractions, 5.5 g (70.5% of theory) of the title compound of m.p. 159.5-161°C are obtained.

EF: C 21

H

24

N

2 0 2 MW: 336.44 Starting from the starting compounds described below, the following is obtained according to the procedure as in Example 28: 29. (+/-)-cis-9-Ethoxy-8-methoxy-6-(4-aminophenyl)-1,2,3,4,4a,1 b-hexahydrophenanthridine 183-186°C, yield 30.8% of theory EF: C 22

H

26

N

2 0 2 MW: 350.47 Elemental analysis: calc.: C 75.40 H 7.48 N 7.99 fnd: C 75.72 H 7.53 N 7.70 i ill B580WOO 03974 27 (+/-)-cis-8,9-Dimethoxy-6-[4-bis(p-nitrophenylsulfonyl)aminophenyll-1,2,3,4,4a,10bhexahydrophenanthridine 1.45 g of 4-nitrobenzenesulfonyl chloride in 20 ml of methylene chloride are added dropwise to a solution of 2.0 g of (+/-)-cis-8,9-dimethoxy-6-(4-aminophenyl)-1,2,3,4,4a,10b-hexahydrophenanthridine in ml of methylene chloride and 1.0 ml of triethylamine. The solution is stirred overnight at RT, extracted with water, and the organic phase is dried and concentrated. The residue is chromatographed on silica gel using a mixture of petroleum ether/ethyl acetate in the ratio 3:2. After concentration of the corresponding eluate fractions, the title compound of m.p. 234.5 0 C is obtained.

EF: C 33

H

30

N

4 0 1 oS 2 MW: 706.76 Elemental analysis: calc.: C 56.08 H 4.28 N 7.93 S 9.07 fnd: C 55.93 H 4.29 N 7.73 S 8.86 31. (+/-)-cis-8,9-Dimethoxy-6-(4-acetamidophenyl)-1,2,3,4,4a,1 b-hexahydrophenanthridine g of (+/-)-cis-8,9-dimethoxy-6-(4-aminophenyl)-1,2,3,4,4a,10b-hexahydrophenanthridine is suspended in 10 ml of acetic anhydride and the suspension is stirred at RT for 1 h. The solution is treated with diethyl ether, and the precipitate is filtered off with suction and extracted with sodium hydrogencarbonate solution/ ethyl acetate. After drying and concentration of the organic phase, the residue is recrystallized from ethyl acetate/methanol. 0.63 g (56.0% of theory) of the title compound of m.p. 218 0 C is obtained.

EF: C 23

H

26

N

2 0 3 MW: 378.48 Elemental analysis: calc.: C 72.99 H 6.92 N 7.40 fnd: C 72.93 H 6.91 N 7.33 Starting from the starting compounds described below, the following is obtained according to the procedure as in Example 31: 32. (+/-)-cis-9-Ethoxy-8-methoxy-6-(4-acetamidophenvl)-1,2,3,4,4a,10bhexahydrophenanthridine Solidifying oil, yield 69.7% of theory EF: C 24

H

28

N

2 0 3 MW 392.50 Elemental analysis: calc.: C 73.44 H 7.19 N 7.14 fnd: C 73.01 H 7.38 N 6.68 B580W00 03974 28 33. (+/-)-cis-8,9-Dimethoxy-6-r4-bis(p-toluenesulfonl)aminophenlvl-1,2,3,4,4a,10bhexahydrophenanthridine g of (+/-)-cis-8,9-dimethoxy-6-(4-p-toluenesulfonamidophenyl)-1,2,3,4,4a,1 Ob-hexahydrophenanthridine in 5 ml of dimethylformamide and then 1.0 g of p-toluenesulfonyl chloride in 5 ml of dimethylformamide are added dropwise to a suspension of 200 mg of 80% strength sodium hydride in 20 ml of dimethylformamide. After stirring at RT for 2 h, the mixture is added to ice-water and extracted with ethyl acetate/diethyl ether in the ratio 1:1. After drying and concentration of the organic phase, the residue is chromatographed on silica gel using a mixture of ethyl acetate/petroleum ether in the ratio 4:1.

After concentration of the corresponding eluate fractions, the title compound of m.p. 120-130 0 C is obtained.

EF: C 35

H

36

N

2 0 6

S

2 MW: 644.81 Elemental analysis: calc.: C 64.30 H 5.70 N 4.28 S 9.81 fnd: C 64.19 H 5.71 N 4.22 S 9.74 34. (+/-)-cis-8,9-Dimethoxy-6-[(N-acetyI-4-p-toluenesulfonamido)phenlVIl-1,2,3,4,4a,10 bhexahydrophenanthridine g of (+/-)-cis-8,9-dimethoxy-6-(4-p-toluenesulfonamidophenyl)-1,2,3,4,4a,1 Ob-hexahydrophenanthridine in 5 ml of dimethylformamide and then 0.5 ml of acetyl chloride in 5 ml of dimethylformamide are added dropwise to a suspension of 100 mg of 80% strength sodium hydride in 10 ml of dimethylformamide. The mixture is stirred overnight at RT, added to sodium hydrogencarbonate solution and extracted with ethyl acetate. After drying and concentration of the organic phase, the residue is chromatographed on silica gel using a mixture of toluene/dioxane in the ratio 2:1. After concentration of the appropriate eluate fractions, the title compound of m.p. 212-216*C is obtained.

EF: C 30

H

32

N

2 0 5 S; MW 532.66 Elemental analysis: calc.: C 67.65 H 6.06 N 5.26 S 6.02 fnd: C 67.71 H 6.03 N 5.21 S 5.83 Starting from the starting compounds described below, the following is obtained according to the procedure as in Example 34: (+/-)-cis-8,9-Diethoxy-6-r(N-acetyl-4-p-toluenesulfonamido)phenyil-1,2,3,4,4a,10bhexahydrophenanthridine Solidified oil, yield 41.6% of theory EF: C 32

H

36

N

2 0 5 S; MW 560.72 t k It B580WOO 03974 29 Elemental analysis: calc.: C 68.55 H 6.74 N 5.00 S 5.72 fnd: C 68.71 H 6.49 N 4.81 S 5.52 36. (+/-)-cis-9-Ethoxy-8-methoxy-6-r(N-methyl-4-p-toluenesulfonamido)phenvll- 1,2,3,4,4a,10b-hexahydrophenanthridine mg of 80% strength sodium hydride are suspended in 10 ml of dimethylformamide under nitrogen, treated with 500 mg of (+/-)-cis-9-ethoxy-8-methoxy-6-(4-p-toluenesulfonamidophenyl)-1,2,3,4,4a,10bhexahydrophenanthridine dissolved in 5 ml of dimethylformamide and 70 pi of methyl iodide dissolved in 5 ml of dimethylformamide and stirred overnight at RT. After hydrolysis with water, the mixture is extracted with diethyl ether and the organic phase is then dried using sodium sulfate and concentrated.

The residue is chromatographed on silica gel using a mixture of petroleum ether/ethyl acetate/methanol in the ratio 6/3/1. After concentration of the corresponding eluate fractions, 150 mg (28.9% of theory) of the title compound are obtained as a solidifying oil.

EF: C3oH34N 2 0 4 S; MW 518.68 Elemental analysis: calc.: C 68.29 H 6.69 N 5.31 S 6.08 fnd: C 68.84 H 6.69 N 5.32 S 6.07 37. (+/-)-cis-8,9-Diethoxy-6-(4-hydroxyphenyl)-1,2,3,4,4a,10b-hexahydrophenanthridine 2.68 g of (+/-)-cis-6-(4-acetoxyphenyl)-8,9-diethoxy-1,2,3,4,4a,10b-hexahydrophenanthridine are dissolved in 15 ml of methanol, treated with 1.1 g of potassium hydroxide and the mixture is stirred at RT for 2 h. After removal of the solvent in vacuo, the residue is taken up in water, rendered neutral and extracted with ethyl acetate. The organic phase is dried using sodium sulfate and the solvent is removed in vacuo. 1.23 g (51.2% of theory) of the title compound of m.p. 232-234°C are obtained.

EF: C 23

H

27 N0 3 MW 365.48 Elemental analysis: (x 0.6 H 2 0): calc.: C 73.42 H 7.55 N 3.72 fnd: C 73.51 H 7.39 N 3.79 B580W00 06974 Starting compounds Al. (+--i--2(,-iehxpev~~lhxl---ounsloaioezmd 6.4 g of 1,2-d imethoxy-4-(2-am inocyclohexyl)belzefe are dissolved in 150 ml of methylene chloride and 9 ml of triethylamine. A solution of 11.2 g of 4-p-toluenesulfonamidobenzoyl chloride in 200 ml of methylene chloride is added dropwise at RT in the course of 3 h, and the mixture is extracted after stirring for 1 h with 100 ml each of water, 2N hydrochloric acid, satd. sodium hydrogencarbonate solution and water again. The organic phase is dried using sodium sulfate, concentrated and crystallized from ethyl acetate. 3.9 g (28.2% of theory) of the title compound of m.p. 174-1 7600 are obtained.

Starting from the starting compounds described below, the following are obtained according to the procedure as in Example Al: A2. (+--i--2(,-itovhnlccohxl---ounsloaioezmd Solidifying oil; yield 70.6%.of theory.

A3. (+/-)-cis-N-f2-(3-Cyclopentlox-4-methovhevl)cvcIohexyl1-4_-ptoluenesulfonamidobenzamide Oil; yield 71.6% of theory.

A4. (+/-)-cis-N-r2-(4-Cvclopentvloxy-3-methoxvphenvlccohexll-4-ptoluenesulfonamidobenzamide 90'C, yield 55.6% of theory.

(+/-)cis-N-2-(3,4-Dimethoxvphenvl)cvclohxvI-4-litrobelzamlide 12200, yield 98.0% of theory.

A6. (+I-)cis-N-r2-(3,4-DimethoxVphenyl)cvclohexvll-2,6-dichlorobenzamide 181-184.5'C, yield quantitative.

A7. (+--i--2(,-iehxpev~ccoeyl34dmto~ezmd IOil, yield quantitative.

i B580WOO 03974 31 A8. (+--i--2(,-iehxpey)45dmtvccoe--nitoluenesulfonamidobenzamide 129-141 0 C, yield 31.5% of theory.

A9. (+--rn--2(,-iehkpev~vlhxl---ounsloaioezmd 214-220'C, yield 34.5% of theory.

Al 0. (+/-)-trans-N4[2-(3,4-Dimethoxphenl)cvclohex-4-elvil-4-;p toluenesulfonamidobenzamide 119-126*C, yield 93.5% of theory.

All1. (+/-)-trans-N-r2-(3,4-Dimethoxvhenv)4,5-dimethvlcvclohex-4-enlV-4-ptoluenes ulfon amid obenzamide 139'C (decomposition), yield 64.9% of theory.

Al12. (+-)-trans-N-r2-(3,4-Dimethoxvhenvi)-bicyclo2.2.2loct-2-Vl-4-ptoluenesulfonamidobenzamide Oil, yield 52.5% of theory.

Al 3. (+I-)-cis-N-2-(3.4-Diethoxvphenvl)cvclohexvll-4-acetoxvbenzamide 81-84 0 C, yield 75.8% of theory.

A14.- (+/-)cis-N-2-(34-DiethoxvphenvI)cvclohexvI1-4-benzvlbenzamide 146-1 5000, yield 72.7% of theory.

(+I-)-cis-N-r2-34-Diethoxvphenvl)cvclohexvll-4-phenvlbenzamide 151 -15400, yield 48.0% of theory.

Al16. (+--i--2(,-itovhnv~vlhxl--looezmd 149-150*C, yield 63.0% of theory.

B580WOO 03974 Al 7. (+~i--2(,-ito~henlcclhey1--rf rmehlb zmi 155-156'C, yield 85.7% of theory.

AlI8. (+/-)-cis-N-r2-(3,4-Diethoxyphenvl)cvclohexVll-4-cyaflobeflzamide 165-167*C, yield 75.3% of theory.

Al 9. (+/-)-cis-N-r2-(3,4-Diethoxyphenl)cVcohexI1-4-trifIuoromethoxVbelzamlide 111-1 13.5'C, yield 38.9% of theory.

(+--i--2(-toV4mtovhnlccoeyl4ptleesloaioezmd 143-150*C, yield 60.7% of theory.

A21. (+/-)-cis-N-i2-(3-Ethoxy-4-methoxphenvl)cvciohexVI1-4-flitrobenzamide 120-140'C, yield 89.0% of theory.

A22. (+--i--2(-toy4mtovhnlccoeyl4mtaeufniezmd 180-181 0 C, yield 75.3% of theory.

A23. (+--i--2(-toy4mtovhnl~vlhxI--4mtoyabnlhn1 sulfonamidobenzamide 176-182 0 C, yield 42.4% of theory.

A24. (+I-)-cis-N-r2-(3,4-Diethoxvphenl)cvclohexll-4-isoflicotiflamide g of 1,2-d iethoxy-4-(2-aminocyclohexyl)benzene are dissolved in 30 ml of methylene chloride and 5 ml of triethylamine. A suspension of 2.0 g of isonicotinoyl chloride in 30 ml of methylenie chloride is added dropwise at RT in the course of 3 h, and the mixture is extracted after stirring for 1 h with ml each of water, 2N hydrochloric acid, satd. sodium hydrogencarbonate solution and water again.

The organic phase is dried using sodium sulfate and concentrated, and the residue is chromatographed on silica gel using a mixture of toluene/dioxane/petroleum ether! triethylamine in the ratio 6:2:1:0.5.

After concentration of the corresponding eluates, 3.44 g (98.3% of theory) of the title compound are obtained as a solidifying oil.

I i. I B580 WOO 03974 Starting from the starting compounds described below, the following are obtained according to the procedure as in Example A24: (+/-)cis-N-r2-(3,4-Diethoxvphenvl)cvclohexyI1-4-flicotiflamide Solidifying oil; yield quantitative.

A26. (+/-)-cis-N-r2-(3,4-Diethoxvphenvl)rvcohexVll-6-chloroflicotiflamide Oil; yield 59.0% of theory.

B1. ,2-Dimethoxy-4-(2-aminocyclohexvl)benzene g of ,2-dimethoxy-4-(2-nitrocyclohexyl)benzene are dissolved in 400 ml of methanol and treated in portions with 7 ml of hydrazine hydrate and 2.5 g of Raney nickel at RT in the course of 8 h.

After stirring overnight at RT, the reaction mixture is filtered, the filtrate is concentrated and the residue is chromatographed on silica gel using a mixture of toluene/ethyl acetate/triethylamine Oil; yield 74.4% of theory.

Starting from the starting compounds described below, the following are obtained according to the procedure as in Example Bi: B2. (+I)-cis-11,2-Dieth oxy-4-(2-am inocyclohexvl) benzene Oil; yield 42.8% of theory.

B3. (+/-)-cis-2-Cyclopentyloxy-l-.methoxy-4-(2-am inocyclohexvl)benzene Oil; yield 68.2% of theory.

B4. -Cyclopentyloxy-2-methoxv-4-(2-aminocyfclohexvl)benzefle Oil; yield 69.0% of theory.

(+/-)-cis-1,2Dimethoxy-4"(2-amino-4,5-dimethylcy clohex-4-el)belzefle Oil; yield 87.3% of theory.

B580W00 03974 34 B6. f+I-)-trans-1 ,2-Dimethoxy-4-(2-aminocvclohexVl)benzefle Oil; yield 65.9% of theory.

B7. (+I-)-trans-l ,2-Dimethoxy-4-(2-aminocvctohex-4-envI)belzefle Oil; yield 28.9% of theory.

B8. ra ns-1 ,2-Dimethoxy-4-(2-a min o-4,5-di methylcycloh ex-4-enVl)benzen e Solidified oil, yield 94% of theory.

B9. (+I-)-trans-3-(3,4-Dimethoxyphenl)-bicVcof2.2.2loct-2-vlamlifle Oil, yield 70.7% of theory.

B1 0. (+/+)cis-2-Ethoxy-1 -meth oxy-4-(2-ami nocvc lohexvl) benzene 40.0 g of (+I-)-cis-2-ethoxy-l -methoxy-4-(2-nitrocyclohex-4-enyl)benzene are dissolved in 1000 ml of ethanol and 500 ml of tetrahydrofuran, treated with 10 g of Raney nickel and hydrogenated at RT in an autoclave for 4 days at a hydrogen pressure of 100 bar. After filtration and removal of the solvent in vacuo, 35.9 g (99.8% of theory) of the title compound are obtained as a solidifying oil.

Cl. ,2-Dimethoxy-4-(2-nitrocyclohexvl)benzene 8.4 g of 1,2-dimethoxy-4-(2-nitrocyclohex-4-enyl)benzene are dissolved in 450 ml of methanol, treated with 2 ml of conc. hydrochloric acid and hydrogenated after addition of 500 mg of Pd/C 10%1 strength. The reaction mixture is filtered and the filtrate is concentrated. 84-86.5 0 C; yield quantitative.

Starting from the starting compounds described below, the following are obtained according to the procedure as in Example Cl: C2. 1+/I--cis-1 .2-Diethoxv-4-(2-nitrocvclohexyl)benzene Oil; yield 96.5% of theory.

t B580W00 03974 C3. (i.I-)-cis-2-Cycopentvloxv-1-methox-4-(2-litrocyclohexVI)belzefle 107.5 0 C, yield 53.5% of theory.

C4. Ccoetlx--ehx--2ntoylhx-~ezn 92-94.50C, yield 74.8% of theory.

(+/+)trans-1 ,2-Dimethoxy-4-(2 -nitrocvclohexyl)beflzefl Oil; yield 47.0% of theory.

C6. (+--rn--34Dmtovhnl--irbcco 22otn Oil, yield 76.0% of theory.

D1. ,2-Dimethoxy-4-;(2-nitrocyclohex-4-enlI)belzefle 10.0 g of ,2-dimethoxy-4-(2nitrocyclohex-4-enyi)benzene and 20.0 g of potassium hydroxide are dissolved in 150 ml of ethanol and 35 ml of dimethylformamide. A solution of 17.5 ml of conc.

sulfuric acid in 60 ml of ethanol is then added dropwise such that the internal temperature does not exceed 4*C. After stirring for 1 h, the mixture is added to 1 1 of ice-water, the precipitate is filtered off with suction, washed with water and dried and the crudeproduct is recrystallized from ethanol. M.p.: 82.5-84*C; yield 86% of theory.

Starting from the starting compounds described below, the following are obtained according to the procedure as in Example DlI: 02. .2-Diethoxy-4-(2-nitrocVclohex-4-elV~belzefle Oil; yield 96.5% of theory.

D3. (+I-)cis-2-CYclooentvloxY-1 -methoxy-4-(2-nitrocvclohex-4-evl)belzefle 78-81 0 C, yield 89.2% of theory.

D4. f+I-)-cis-l -Cyclonentylox-2-methoxV-4-(2-flitrocVclohex-4-eny )belzefle 81 .5-850C, yield quantitative.

B580W00 03974 36 66.67*G, yield 97.2% of theory.

D6. (+/-)-cis-2-Dimethoxv-4-(4,5-dimethl-2-litrocyclohex-4-eflyl)belzefle 97.5*C, yield 91.8% of theory.

El. (+I-)-trans-l ,2-Dimethoxy-4-(2-nitrocvclohex-4-enl)belzefle 50.0 g of 3,4-dimethoxy-co-nitrostyrene and 1.9 g (9.1 mmol) of hydroquinone are suspended in 200 ml of abs. toluene and treated at -70'C with 55.0 g (1.02 mol) of liquid 1 ,3-butadiene. The mixture is stirred at 1600C for 6 days in an autoclave and then cooled. Some of the solvent is distilled off in vacuo, and the resulting precipitate is filtered off with suction and recrystallized in ethanol. 113.5-115.5*C; yield 76.3% of theory.

Starting from the starting compounds described below, the following are obtained according to the procedure as in Example El: E2. f+/-)-trans-1 .2-Diethoxy-4-(2-n itrocyclohex-4-envl)benzene 80-81.500; yield 59.8% of theory.

E3. W+-)-trans-2-Cyclopentyloxy-l -methoxy-4-(2-nitrocyclohex-4-enl)belzefle 135-136'C; yield 77.7% of theory.

E4. (+I-)-trans-l -Cyclopentyloxy-2-meth oxv-4-(2-n itrocclohex-4-eyl) benzenle 109'C; yield 7 1.1 of theory.

W+-M-rans-2-Ethoxy-l -methoxy-4-(2-nitrocvclohex-4-envl)belzefle 129-130*C; yield 75.7% of theory.

E6. f+I-)-trans-l ,2-Dimethoxy-4-(4.5-d imethyl-2-nitrocyclohex-4-envl)benzefle 131 .5 0 C; yield 79.3% of theory.

J ,1 B580W00 03974 37 E7. (+--rn--34Dmtovhnl)6ntoivl[..lc--n Oil, yield quantitative.

Fl. 3,4-DimethoxV-&w-nitrostyrene 207.0 g of 3,4-dimethoxybenzaldehyde, 100.0 g of ammonium acetate and 125 ml of nitromethane are heated to boiling for 3-4 h in 1.0 1 of glacial acetic acid. After cooling in an ice-bath, the precipitate is filtered off with suction, rinsed with glacial acetic acid and petroleum ether and dried., 140-141 *C.

Yield: 179.0 g (68.5% of theory).

Starting from corresponding starting compounds of the formula VII, the following are obtained analogously to the procedure as in Example Fl: F2. 3,4-Diethoxy-w-nitrostvrene 136-136.5*C; yield: 76.2% of theory.

F3. 3-Cyclopentvloxy-4-methox-o-flitrostyrele 137-138OC; yield: 86.6% of theory.

F4. 4-Cvclopentvloxy-3-methoxv-w-nitrostyrefle 90-91 yield: 44.0% of theory.

3-Ethoxy-4-methoxy-w-nitrostyrene 132-133 0 C; yield: 70.3% of theory.

B580WOO 03974 38 Commercial utility The compounds according to the invention have valuable pharmacological properties which make them commercially utilizable. As selective cyclic nucleotide phosphodiesterase (PDE) inhibitors (mainly of type IV), they are suitable on the one hand as bronchial therapeutics (for the treatment of airway obstructions on account of their dilating but also on account of their respiratory rate- and respiratory driveincreasing action) and for the elimination of erectile dysfunction on account of the vasodilating action, but on the other hand especially for the treatment of disorders, in particular of inflammatory nature, e.g.

of the airways (asthma prophylaxis), of the skin, of the intestine, of the eyes, of the central nervous system and of the joints, which are mediated by mediators such as histamine, PAF (platelet-activating factor), arachidonic acid derivatives such as leukotrienes and prostaglandins, cytokines, interleukins, chemokines, alpha-, beta- and gamma-interferon, tumor necrosis factor (TNF) or oxygen free radicals and proteases. In this case, the compounds according to the invention are distinguished by a low toxicity, a good enteral absorption (high bioavailability), a large therapeutic breadth and the absence of significant side effects.

On account of their PDE-inhibiting properties, the compounds according to the invention can be employed as therapeutics in human and veterinary medicine, where they can be used, for example, for the treatment and prophylaxis of the following diseases: acute and chronic (in particular inflammatory and allergen-induced) airway disorders of various origins (bronchitis, allergic bronchitis, bronchial asthma); dermatoses (especially of proliferative, inflammatory and allergic type) such as, for example, psoriasis (vulgaris), toxic and allergic contact eczema, atopic eczema, seborrheic eczema, lichen simplex, sunburn, pruritus in the anogenital area, alopecia areata, hypertrophic scars, discoid lupus erythematosus, follicular and wide-area pyodermias, endogenous and exogenous acne, acne rosacea and other proliferative, inflammatory and allergic skin disorders; disorders which are based on an excessive release of TNF and leukotrienes, thus, for example, disorders of the arthritis type (rheumatoid arthritis, rheumatoid spondylitis, osteoarthritis and other arthritic conditions), disorders of the immune system (AIDS, multiple sclerosis), types of shock [septic shock, endotoxin shock, gram-negative sepsis, toxic shock syndrome and ARDS (adult respiratory distress syndrome)] as well as generalized inflammations in the gastrointestinal area (Crohn's disease and ulcerative colitis); disorders which are based on allergic and/or chronic, abnormal immunological reactions in the area of the upper airways (pharynx, nose) and the adjacent regions (paranasal sinuses, eyes), such as, for example, allergic rhinitis/sinusitis, chronic rhinitis/ sinusitis, allergic conjunctivitis and nasal polyps; but also disorders of the heart which can be treated by PDE inhibitors, such as, for example, cardiac insufficiency, or disorders which can be treated on account of the tissue-relaxant action of the PDE inhibitors, such as, for example, erectile dysfunction or colics of the kidneys and of the ureters in connection with kidney stones.

The invention further relates to a procedure for the treatment of mammals including humans who are suffering from one of the abovementioned illnesses. The process comprises administering to the sick B580W00 03974 39 mammal a therapeutically efficacious and pharmacologically tolerable amount of one or more of the compounds according to the invention.

The invention further relates to the compounds according to the invention for use in the treatment and/or prophylaxis of the illnesses mentioned.

The invention likewise relates to the use of the compounds according to the invention forthe production of medicaments which are employed for the treatment and/or prophylaxis of the illnesses mentioned.

Medicaments for the treatment and/or prophylaxis of the illnesses mentioned which contain one or more of the compounds according to the invention are furthermore a subject of the invention.

The medicaments are prepared by processes known per se and familiar to the person skilled in the art.

As medicaments, the compounds according to the invention active compounds) are either employed as such, or preferably in combination with suitable pharmaceutical auxiliaries, e.g. in the form of tablets, coated tablets, capsules, suppositories, patches, emulsions, suspensions, gels or solutions, the active compound content advantageously being between 0.1 and The person skilled in the art is familiar on the basis of his expert knowledge with the auxiliaries which are suitable for the desired pharmaceutical formulations. In addition to solvents, gel-forming agents, ointment bases and other active compound excipients, it is possible to use, for example, antioxidants, dispersants, emulsifiers, preservatives, solubilizers or permeation promoters.

For the treatment of disorders of the respiratory tracts, the compounds according to the invention are preferably also administered by inhalation. For this purpose, these are either administered directly as a powder (preferably in micronized form) or by atomization of solutions or suspensions which contain them. With respect to the preparations and administration forms, reference is made, for example, to the embodiments in European Patent 163 965.

For the treatment of dermatoses, the compounds according to the invention are administered, in particular, in the form of those medicaments which are suitable for topical application. For the production of the medicaments, the compounds according to the invention active compounds) are preferably mixed with suitable pharmaceutical auxiliaries and processed further to give suitable pharmaceutical formulations. Suitable pharmaceutical formulations which may be mentioned are, for example, powders, emulsions, suspensions, sprays, oils, ointments, fatty ointments, creams, pastes, gels or solutions.

The medicaments according to the invention are prepared by processes known per se. The active compounds are administered in the order of magnitude customary for PDE inhibitors. Thus topical application forms (such as, for example, ointments) for the treatment of dermatoses contain the active B580WOO 03974 compounds in a concentration of, for example, 0.1-99%. The dose for administration by inhalation is customarily between 0.01 and 1 mg per burst of spray. The customary dose in the case of systemic therapy p.o. or i.v. is between 0.1 and 200 mg per administration.

B580WOO 03974 41 Biological investigations In the investigation of PDE IV inhibition at the cellular level, the-activation of inflammatory cells is of particular importance. An example which may be mentioned is the FMLP (N-formylmethionylleucylphenylalanine)-induced superoxide production of neutrophilic granulocytes, which can be measured as luminol-potentiated chemoluminescence [Mc Phail LC, Strum SL, Leone PA and Sozzani S, The neutrophil respiratory burst mechanism. In "Immunology Series" 1992, 57, 47-76; ed. Coffey RG (Marcel Decker, Inc., New York-Basle-Hong Kong)].

Substances which inhibit chemoluminescence and cytokine secretion and the secretion of proinflammatory mediators on inflammatory cells, in particular neutrophilic and eosinophilic granulocytes, T lymphocytes, monocytes and macrophages, are those which inhibit PDE IV. This isoenzyme of the phosphodiesterase families is particularly represented in granulocytes. Its inhibition leads to the increase of the intracellular cyclic AMP concentration and thus to the inhibition of cellular activation. PDE IV inhibition by the substances according to the invention is thus a central indicator of the suppression of inflammatory processes. (Giembycz MA, Could isoenzyme-selective phosphodiesterase inhibitors render bronchodilatory therapy redundant in the treatment of bronchial asthma? Biochem Pharmacol 1992, 43, 2041-2051; Torphy TJ et al., Phosphodiesterase inhibitors: new opportunities for treatment of asthma. Thorax 1991, 46, 512-523; Schudt C et al., Zardaverine: a cyclic AMP PDE III/IV inhibitor. In "New Drugs for Asthma Therapy", 379-402, Birkhiuser Verlag Basle 1991; Schudt C et al., Influence of selective phosphodiesterase inhibitors on human neutrophil functions and levels of cAMP and Cal.

Naunyn-Schmiedeberg's Arch Pharmacol 1991, 344, 682-690; Nielson CP et al., Effects of selective phosphodiesterase inhibitors on polymorphonuclear leukocyte respiratory burst. J Allergy Clin Immunol 1990, 86, 801-808; Schade et al., The specific type III and IV phosphodiesterase inhibitor zardaverine suppress formation of tumor necrosis factor by macrophages. European Journal of Pharmacology 1993, 230, 9-14).

B580WOO 03974 1. Inhibition of PDE IV activity Methodology The activity test was carried out according to the method of Bauer and Schwabe, which was adapted to microtiter plates (Naunyn-Schmiedeberg's Arch. Pharmacol. 1980, 311, 193-198). In this test, the PDE reaction is carried out in the first step. In a second step the resulting 5'-nucleotide is cleaved to give the uncharged nucleoside by means of a 5'-nucleotidase of the snake venom from Crotalus atrox. In the third step, the nucleoside is separated from the remaining charged substrate on ion-exchange columns.

Using 2 ml of 30 mM ammonium formate (pH the columns are eluted directly into minivials, to which 2 ml of scintillator fluid is additionally added for counting.

The inhibitory values determined for the compounds according to the invention follow from the following Table A, in which the numbers of the compounds correspond to the numbers of the examples.

Table A Inhibition of the PDE IV activity Compound -log ICso 1 7.73 2 8.39 3 7.76 4 6.12 7.22 6 6.77 7 6.44 8 6.91 9 6.17 6.10 12 5.77 13 8.43 14 8.08 7.98 16 7.93 17 8.00 18 8.24 19 7.97 0-i B580W00 03974 Table A continued Compound -log ICS 0 9.05 21 8.46 22 8.66 23 8.70 24 8.08 7.96 26 8.41 27 6.66 29 7.69 7.36 31 7.30 32 8.38 33 7.27 34 7.42 7.81 36 9.09 37 8.04

Claims

1. A compound of the formula I R R3 R4 HR51 R2 R6 1) in which R1 is hydroxyl, 1-4C-alkoxy, 3-7C-cycloalkoxy, 3-7C-cycloalkylmethoxy or 1-4C-alkoxy which is completely or partially substituted by fluorine, R2 is hydroxyl, 1-4C-alkoxy, 3-7C-cycloalkoxy, 3-7C-cycloalkylmethoxy or 1-4C-alkoxy which is completely or partially substituted by fluorine, or in which R1 and R2 together are a 1-2C-alkylenedioxy group, R3 is hydrogen or 1-4C-alkyl, R31 is hydrogen or 1-4C-alkyl, or in which R3 and R31 together are a 1-4C-alkylene group, R4 is hydrogen or 1-4C-alkyl, is hydrogen, R51 is hydrogen, or in which and R51 together are an additional bond, R6 is a pyridyl radical which is substituted by R61 or a phenyl radical which is substituted by R7 and R8, where R61 is hydrogen, hydroxyl, halogen, 1-4C-alkoxy, 1-4C-alkyl, carboxyl, trifluoromethyl, 1-4C-alkoxy- carbonyl or 1-4C-alkoxy which is completely or partially substituted by fluorine, R7 is hydroxyl, halogen, cyano, 1-4C-alkyl, 1-4C-alkoxy, 1-4C-alkylcarbonyloxy, trifluoromethyl, phenyl, phenyl-1-4C-alkyl, nitro, amino, 1-4C-alkoxy which is completely or partially substituted by fluorine, or is S0 2 -R70 or N(R71)R72, where is 1-4C-alkyl, R71 is hydrogen, 1-4C-alkyl, SO2-R9 or S0 2 -R10 and R72 is 1-4C-alkyl, 1-4C-alkylcarbonyl or S0 2 is hydrogen, hydroxyl, halogen, 1-4C-alkoxy or 1-4C-alkyl S1' B580WOO 03974 and where R9 and R10 independently of one another are 1-4C-alkyl, phenyl, phenyl-1-4C-alkyl or phenyl which is substituted by one or more identical or different substituents, where the substituents are se- lected from the group consisting of nitro, 1-4C-alkyl, halogen, 1-4C-alkylcarbonylamino, 1-4C- alkoxy, 1-4C-alkoxy which is completely or partially substituted by fluorine, cyano, phenyl, naphthyl, trifluoromethyl and 1-4C-alkoxycarbonyl, or the salts of this compound.

2. A compound of the formula I as claimed in claim 1, in which R1 is hydroxyl, 1-4C-alkoxy, 3-7C-cycloalkoxy, 3-7C-cycloalkylmethoxy or 1-4C-alkoxy which is completely or partially substituted by fluorine, R2 is hydroxyl, 1-4C-alkoxy, 3-7C-cycloalkoxy, 3-7C-cycloalkylmethoxy or 1-4C-alkoxy which is completely or partially substituted by fluorine, or in which R1 and R2 together are a 1-2C-alkylenedioxy group, R3 is hydrogen or 1-4C-alkyl, R31 is hydrogen or 1-4C-alkyl, or in which R3 and R31 together are a 1-4C-alkylene group, R4 is hydrogen or 1-4C-alkyl, is hydrogen, R51 is hydrogen, or in which and R51 together are an additional bond, R6 is a pyridyl radical which is substituted by R61, where R61 is hydrogen, hydroxyl, halogen, 1-4C-alkoxy, 1-4C-alkyl, carboxyl, trifluoromethyl, 1-4C-alkoxy- carbonyl or 1-4C-alkoxy which is completely or partially substituted by fluorine, or the salts of this compound.

3. A compound of the formula I as claimed in claim 1, in which R1 is hydroxyl, 1-4C-alkoxy, 3-7C-cycloalkoxy, 3-7C-cycloalkylmethoxy or 1-4C-alkoxy which is completely or partially substituted by fluorine, R2 is hydroxyl, 1-4C-alkoxy, 3-7C-cycloalkoxy, 3-7C-cycloalkylmethoxy or 1-4C-alkoxy which is completely or partially substituted by fluorine, or in which R1 and R2 together are a 1-2C-alkylenedioxy group, R3 is hydrogen or 1-4C-alkyl, R31 is hydrogen or 1-4C-alkyl, ,or in which B580WOO 03974 46 R3 and R31 together are a 1-4C-alkylene group, R4 is hydrogen or 1-4C-alkyl, is hydrogen, R51 is hydrogen, or in which and R51 together are an additional bond, R6 is a phenyl radical which is substituted by R7 and R8, where R7 is hydroxyl, halogen, cyano, 1-4C-alkyl, 1-4C-alkoxy, 1-4C-alkylcarbonyloxy, trifluoromethyl, phenyl, phenyl-1-4C-alkyl, nitro, amino or N(R71)R72, where R71 is hydrogen, 1-4C-alkyl, S0 2 -R9 or SO2-R10 and R72 is 1-4C-alkyl, 1-4C-alkylcarbonyl or SO2-R10, R8 is hydrogen, hydroxyl, halogen, 1-4C-alkoxy or 1-4C-alkyl and where R9 and R10 independently of one another are 1-4C-alkyl, phenyl, phenyl-l-4C-alkyl or phenyl which is substituted by one or more identical or different substituents, the substituents being selected from the group consisting of nitro, 1-4C-alkyl, halogen, 1-4C-alkylcarbonylamino, 1-4C-alkoxy, 1-4C-alkoxy completely or partially substituted by fluorine, cyano, phenyl, naphthyl and trifluo- romethyl, or the salts of this compound.

4. A compound of the formula I as claimed in claim 1, in which R1 is hydroxyl, 1-4C-alkoxy, 3-7C-cycloalkoxy, 3-7C-cycloalkylmethoxy or 1-4C-alkoxy which is completely or partially substituted by fluorine, R2 is hydroxyl, 1-4C-alkoxy, 3-7C-cycloalkoxy, 3-7C-cycloalkylmethoxy or 1-4C-alkoxy which is completely or partially substituted by fluorine, or in which R1 and R2 together are a 1-2C-alkylenedioxy group, R3 is hydrogen or 1-4C-alkyl, R31 is hydrogen or 1-4C-alkyl, or in which R3 and R31 together are a 1-4C-alkylene group, R4 is hydrogen or 1-4C-alkyl, is hydrogen, R51 is hydrogen, or in which and R51 together are an additional bond, R6 is a phenyl radical which is substituted by R7 and R8, where t B580WOO 03974 47 R7 is hydroxyl, halogen, cyano, 1-4C-alkyl, 1-4C-alkoxy, 1-4C-alkylcarbonyloxy, trifluoromethyl, phenyl, phenyl-1-4C-alkyl, nitro, amino, 1-4C-alkoxy which is completely or partially substituted by fluorine, or is S0 2 -R70 or N(R71)R72, where is 1-4C-alkyl, R71 is hydrogen, 1-4C-alkyl, S0 2 -R9 or S0 2 -R10 and R72 is 1-4C-alkyl, 1-4C-alkylcarbonyl or S0 2 R8 is hydrogen, hydroxyl, halogen, 1-4C-alkoxy or 1-4C-alkyl and where R9 and R10 independently of one another are 1-4C-alkyl, phenyl, phenyl-1-4C-alkyl or phenyl which is substituted by one or more identical or different substituents, the substituents being selected from the group consisting of nitro, 1-4C-alkyl, halogen, 1-4C-alkylcarbonylamino, 1-4C-alkoxy, 1-4C-alkoxy which is completely or partially substituted by fluorine, cyano, phenyl, naphthyl, trifluoromethyl and 1-4C-alkoxycarbonyl, or the salts of this compound.

A compound of the formula I as claimed in claim 1, in which R1 is 1-4C-alkoxy or 3-7C-cycloalkoxy, R2 is 1-4C-alkoxy or 3-7C-cycloalkoxy, R3 is hydrogen, R31 is hydrogen, or in which R3 and R31 together are a 1-2C-alkylene group, R4 is hydrogen or 1-4C-alkyl, is hydrogen, R51 is hydrogen, or in which and R51 together are an additional bond, R6 is a phenyl radical which is substituted by R7 and R8, where R7 is hydroxyl, halogen, cyano, 1-4C-alkoxy, 1-4C-alkylcarbonyloxy, trifluoromethyl, phenyl, phenyl-1-4C-alkyl, nitro, amino, 1-4C-alkoxy which is completely or partially substituted by fluo- rine, or is S0 2 -R70 or N(R71)R72, where is 1-4C-alkyl, R71 is hydrogen, 1-4C-alkyl or S0 2 -R10 and R72 is 1-4C-alkylcarbonyl or SO2-R10, R8 is hydrogen, halogen or 1-4C-alkoxy and where is phenyl which is substituted by a substituent, the substituent being selected from the group con- sisting of nitro, 1-4C-alkyl and 1-4C-alkoxycarbonyl, Wor the salts of this compound. 48

6. A medicament comprising at least one compound of the formula I as claimed in claim 1 together with pharmaceutical auxiliaries and/or excipients.

7. The use of compounds of the formula I as claimed in claim 1 for the production of medicaments for the treatment of airway disorders.

8. A method for the treatment of airway disorders comprising the step of administering compounds of formula I as claimed in claim 1, to a person in need of such treatment. Dated this 16th day of February 2000 BYK GULDEN LOMBERG CHEMISCHE FABRIK GmbH By their Patent Attorneys GRIFFITH HACK Fellows Institute of Patent and Trade Mark Attorneys of Australia oo H:\Emma\Keep\Specis\22910.97.doc 16/02/00 48